Expected LOD scores at a QTL that accounts for 10% of phenotypic variance

If you use this information please cite:
1. Chen WM, Abecasis GR (2006) Estimating the power of variance component linkage analysis in large pedigrees. Genet Epedimiol 30:471-484
2. Pilia G, Chen WM, Scuteri A, Orru M, Albai G, et al. (2006) Heritabilities of cardiovascular and personality traits in 6,148 Sardinians. PLoS Genet 2(8):e132

TRAIT Sample Size BASIC Model HOUSEHOLD Model
H2Approx2Approx3Approx3' H2Approx2Approx3Approx3'
Note:
1. Expected LOD scores are predicted analytically at a QTL that accounts for 10% of phenotypic variance, using the variance component models.
2. LOD = NA indicates the overall heritability is less than 10%.
3. Approx 3' approach gives the most accurate LOD predictions according to our simulation study.
ALT 6142 0.238 3.035 2.810 2.866 0.223 3.059 2.830 2.887
AST 6142 0.236 3.034 2.808 2.865 0.213 3.078 2.847 2.905
AT 6043 0.091 NA NA NA 0.078 NA NA NA
BA 6092 0.154 2.950 2.737 2.790 0.152 2.952 2.738 2.792
BILIRUBIN fractionated 6142 0.348 3.159 2.916 2.976 0.340 3.180 2.934 2.996
BILIRUBIN total 6142 0.425 3.294 3.033 3.098 0.413 3.329 3.062 3.129
BMI 6144 0.427 3.301 3.038 3.103 0.355 3.597 3.292 3.368
BUN 6142 0.318 3.117 2.880 2.939 0.309 3.131 2.892 2.952
CHOLESTEROL 6142 0.424 3.293 3.031 3.097 0.374 3.445 3.162 3.233
CRP 6118 0.297 3.066 2.836 2.894 0.274 3.107 2.871 2.930
diam D 6055 0.446 3.267 3.007 3.072 0.393 3.439 3.155 3.226
diam S 6029 0.437 3.218 2.965 3.029 0.388 3.372 3.097 3.166
diastolic BP 6145 0.191 3.013 2.791 2.846 0.123 3.139 2.899 2.959
EDV 6042 0.184 2.926 2.715 2.767 0.117 3.033 2.807 2.863
EO 6092 0.378 3.150 2.908 2.969 0.364 3.186 2.938 3.000
ESR 6137 0.417 3.273 3.014 3.079 0.386 3.372 3.099 3.168
FIBRINOGEN 6138 0.270 3.057 2.828 2.885 0.243 3.100 2.865 2.924
G6PD 6133 0.721 4.270 3.866 3.967 0.716 4.341 3.926 4.030
Gammagt 6142 0.341 3.149 2.907 2.967 0.321 3.192 2.944 3.006
Hb 6130 0.473 3.387 3.112 3.181 0.445 3.483 3.194 3.266
HbA1C 3495 0.587 1.572 1.480 1.503 0.554 1.665 1.561 1.587
HbA2 6134 0.721 4.278 3.872 3.973 0.705 4.452 4.018 4.126
HbF 6096 0.641 3.855 3.514 3.600 0.631 3.924 3.573 3.660
HDL 6142 0.487 3.433 3.152 3.222 0.471 3.507 3.215 3.288
HEIGHT 6146 0.801 4.767 4.282 4.403 0.771 5.717 5.066 5.229
HIP 6145 0.450 3.350 3.080 3.148 0.386 3.601 3.296 3.372
HR 6147 0.272 3.069 2.839 2.897 0.234 3.129 2.890 2.950
IMT 6080 0.187 2.967 2.750 2.804 0.132 3.045 2.817 2.874
IP 6043 0.250 2.963 2.745 2.800 0.171 3.133 2.893 2.953
IRON 6142 0.193 3.010 2.788 2.844 0.186 3.018 2.795 2.851
LDL 6142 0.425 3.295 3.033 3.099 0.377 3.465 3.179 3.251
LY 6092 0.345 3.099 2.863 2.922 0.318 3.151 2.908 2.969
MCH 6130 0.778 4.591 4.134 4.249 0.774 4.633 4.170 4.286
MCV 6130 0.762 4.495 4.053 4.164 0.758 4.534 4.086 4.198
mean BP 6145 0.230 3.033 2.808 2.864 0.147 3.207 2.957 3.020
MO 6092 0.404 3.196 2.947 3.009 0.378 3.264 3.005 3.070
NE 6092 0.346 3.101 2.865 2.924 0.326 3.138 2.897 2.958
NEO A 5657 0.230 2.680 2.495 2.541 0.211 2.704 2.515 2.563
NEO A1 5657 0.205 2.668 2.484 2.530 0.189 2.684 2.498 2.544
NEO A2 5657 0.181 2.659 2.477 2.522 0.131 2.732 2.539 2.588
NEO A3 5657 0.148 2.655 2.473 2.519 0.145 2.658 2.476 2.521
NEO A4 5657 0.128 2.657 2.475 2.521 0.131 2.656 2.475 2.520
NEO A5 5657 0.148 2.655 2.473 2.519 0.120 2.686 2.500 2.546
NEO A6 5657 0.096 NA NA NA 0.079 NA NA NA
NEO C 5657 0.207 2.668 2.484 2.530 0.160 2.726 2.534 2.582
NEO C1 5657 0.168 2.657 2.474 2.520 0.136 2.690 2.503 2.550
NEO C2 5657 0.182 2.660 2.477 2.523 0.173 2.669 2.485 2.531
NEO C3 5657 0.129 2.657 2.475 2.521 0.091 NA NA NA
NEO C4 5657 0.118 2.659 2.477 2.523 0.098 NA NA NA
NEO C5 5657 0.178 2.659 2.476 2.522 0.128 2.720 2.529 2.577
NEO C6 5657 0.156 2.655 2.474 2.519 0.093 NA NA NA
NEO E 5657 0.257 2.699 2.510 2.557 0.220 2.748 2.553 2.602
NEO E1 5657 0.191 2.662 2.479 2.525 0.189 2.664 2.481 2.527
NEO E2 5657 0.221 2.675 2.490 2.536 0.197 2.702 2.513 2.561
NEO E3 5657 0.211 2.670 2.486 2.532 0.146 2.753 2.558 2.607
NEO E4 5657 0.190 2.662 2.479 2.525 0.166 2.686 2.500 2.547
NEO E5 5657 0.157 2.655 2.474 2.519 0.115 2.706 2.518 2.565
NEO E6 5657 0.166 2.656 2.474 2.520 0.147 2.675 2.490 2.536
NEO N 5657 0.258 2.700 2.511 2.558 0.211 2.776 2.577 2.627
NEO N1 5657 0.180 2.659 2.476 2.522 0.145 2.698 2.510 2.557
NEO N2 5657 0.214 2.672 2.487 2.533 0.191 2.699 2.511 2.558
NEO N3 5657 0.247 2.692 2.504 2.551 0.210 2.748 2.553 2.602
NEO N4 5657 0.196 2.664 2.481 2.526 0.184 2.677 2.492 2.538
NEO N5 5657 0.144 2.655 2.474 2.519 0.101 2.710 2.521 2.568
NEO N6 5657 0.137 2.656 2.474 2.519 0.114 2.676 2.492 2.538
NEO O 5657 0.329 2.769 2.571 2.621 0.285 2.872 2.661 2.713
NEO O1 5657 0.218 2.674 2.489 2.535 0.205 2.691 2.504 2.551
NEO O2 5657 0.254 2.696 2.508 2.555 0.222 2.743 2.549 2.598
NEO O3 5657 0.153 2.655 2.473 2.519 0.131 2.679 2.494 2.540
NEO O4 5657 0.185 2.661 2.478 2.523 0.164 2.684 2.498 2.544
NEO O5 5657 0.267 2.707 2.517 2.564 0.241 2.746 2.551 2.600
NEO O6 5657 0.188 2.661 2.478 2.524 0.151 2.704 2.516 2.563
normalized PWV 6048 0.191 2.937 2.723 2.777 0.194 2.938 2.724 2.778
PLT 6127 0.528 3.531 3.236 3.310 0.507 3.627 3.317 3.395
POTASSIUM 6142 0.183 3.007 2.786 2.841 0.177 3.014 2.792 2.848
PR 6104 0.285 3.052 2.823 2.880 0.273 3.074 2.842 2.900
PSA 2604 0.428 0.858 0.829 0.837 0.399 0.869 0.840 0.847
PSV 6044 0.326 3.043 2.815 2.872 0.269 3.181 2.933 2.995
pulse pressure 6145 0.208 3.020 2.797 2.853 0.127 3.190 2.943 3.004
PWV 6048 0.225 2.954 2.738 2.792 0.224 2.956 2.740 2.794
QTC 6147 0.165 3.008 2.787 2.842 0.130 3.051 2.824 2.881
RBC 6125 0.672 4.026 3.658 3.750 0.655 4.156 3.768 3.865
SD ratio 6041 0.264 2.973 2.754 2.809 0.195 3.116 2.877 2.937
SERUM CREATININE 6142 0.346 3.155 2.913 2.973 0.330 3.193 2.945 3.007
SERUM GLUCOSE 6142 0.362 3.180 2.934 2.995 0.314 3.302 3.039 3.104
SERUM INSULIN 5990 0.256 2.918 2.706 2.759 0.239 2.939 2.724 2.778
SODIUM 6142 0.253 3.047 2.820 2.877 0.254 3.048 2.820 2.877
systolic BP 6145 0.259 3.056 2.827 2.884 0.162 3.292 3.030 3.096
TRANSFERRIN 6142 0.197 3.011 2.790 2.845 0.189 3.022 2.799 2.855
TRIGLYCERIDES 6142 0.322 3.122 2.884 2.943 0.295 3.172 2.927 2.988
TSH 3461 0.384 1.155 1.114 1.124 0.373 1.160 1.118 1.128
URIC ACID 6142 0.342 3.150 2.908 2.968 0.338 3.158 2.915 2.976
Vascular mass 6027 0.300 3.009 2.784 2.840 0.246 3.093 2.857 2.916
vti 6043 0.255 2.966 2.748 2.803 0.225 3.011 2.787 2.843
WAIST 6145 0.370 3.197 2.948 3.010 0.312 3.387 3.112 3.181
Wall Lumen 6027 0.224 2.942 2.727 2.781 0.194 2.994 2.771 2.827
WBC 6130 0.384 3.205 2.955 3.017 0.329 3.370 3.097 3.165
WEIGHT 6144 0.498 3.466 3.180 3.251 0.439 3.770 3.440 3.522

Last updated: 2006-10-23 by Wei-Min Chen