If you use this information please cite: 1. Chen WM, Abecasis GR (2006) Estimating the power of variance component linkage analysis in large pedigrees. Genet Epedimiol 30:471-484 2. Pilia G, Chen WM, Scuteri A, Orru M, Albai G, et al. (2006) Heritabilities of cardiovascular and personality traits in 6,148 Sardinians. PLoS Genet 2(8):e132
TRAIT | Sample Size | BASIC Model | HOUSEHOLD Model | |||||||
---|---|---|---|---|---|---|---|---|---|---|
H2 | Approx2 | Approx3 | Approx3' | H2 | Approx2 | Approx3 | Approx3' | |||
Note: | ||||||||||
1. Expected LOD scores are predicted analytically at a QTL that accounts for 10% of phenotypic variance, using the variance component models. | ||||||||||
2. LOD = NA indicates the overall heritability is less than 10%. | ||||||||||
3. Approx 3' approach gives the most accurate LOD predictions according to our simulation study. | ||||||||||
ALT | 6142 | 0.238 | 3.035 | 2.810 | 2.866 | 0.223 | 3.059 | 2.830 | 2.887 | |
AST | 6142 | 0.236 | 3.034 | 2.808 | 2.865 | 0.213 | 3.078 | 2.847 | 2.905 | |
AT | 6043 | 0.091 | NA | NA | NA | 0.078 | NA | NA | NA | |
BA | 6092 | 0.154 | 2.950 | 2.737 | 2.790 | 0.152 | 2.952 | 2.738 | 2.792 | |
BILIRUBIN fractionated | 6142 | 0.348 | 3.159 | 2.916 | 2.976 | 0.340 | 3.180 | 2.934 | 2.996 | |
BILIRUBIN total | 6142 | 0.425 | 3.294 | 3.033 | 3.098 | 0.413 | 3.329 | 3.062 | 3.129 | |
BMI | 6144 | 0.427 | 3.301 | 3.038 | 3.103 | 0.355 | 3.597 | 3.292 | 3.368 | |
BUN | 6142 | 0.318 | 3.117 | 2.880 | 2.939 | 0.309 | 3.131 | 2.892 | 2.952 | |
CHOLESTEROL | 6142 | 0.424 | 3.293 | 3.031 | 3.097 | 0.374 | 3.445 | 3.162 | 3.233 | |
CRP | 6118 | 0.297 | 3.066 | 2.836 | 2.894 | 0.274 | 3.107 | 2.871 | 2.930 | |
diam D | 6055 | 0.446 | 3.267 | 3.007 | 3.072 | 0.393 | 3.439 | 3.155 | 3.226 | |
diam S | 6029 | 0.437 | 3.218 | 2.965 | 3.029 | 0.388 | 3.372 | 3.097 | 3.166 | |
diastolic BP | 6145 | 0.191 | 3.013 | 2.791 | 2.846 | 0.123 | 3.139 | 2.899 | 2.959 | |
EDV | 6042 | 0.184 | 2.926 | 2.715 | 2.767 | 0.117 | 3.033 | 2.807 | 2.863 | |
EO | 6092 | 0.378 | 3.150 | 2.908 | 2.969 | 0.364 | 3.186 | 2.938 | 3.000 | |
ESR | 6137 | 0.417 | 3.273 | 3.014 | 3.079 | 0.386 | 3.372 | 3.099 | 3.168 | |
FIBRINOGEN | 6138 | 0.270 | 3.057 | 2.828 | 2.885 | 0.243 | 3.100 | 2.865 | 2.924 | |
G6PD | 6133 | 0.721 | 4.270 | 3.866 | 3.967 | 0.716 | 4.341 | 3.926 | 4.030 | |
Gammagt | 6142 | 0.341 | 3.149 | 2.907 | 2.967 | 0.321 | 3.192 | 2.944 | 3.006 | |
Hb | 6130 | 0.473 | 3.387 | 3.112 | 3.181 | 0.445 | 3.483 | 3.194 | 3.266 | |
HbA1C | 3495 | 0.587 | 1.572 | 1.480 | 1.503 | 0.554 | 1.665 | 1.561 | 1.587 | |
HbA2 | 6134 | 0.721 | 4.278 | 3.872 | 3.973 | 0.705 | 4.452 | 4.018 | 4.126 | |
HbF | 6096 | 0.641 | 3.855 | 3.514 | 3.600 | 0.631 | 3.924 | 3.573 | 3.660 | |
HDL | 6142 | 0.487 | 3.433 | 3.152 | 3.222 | 0.471 | 3.507 | 3.215 | 3.288 | |
HEIGHT | 6146 | 0.801 | 4.767 | 4.282 | 4.403 | 0.771 | 5.717 | 5.066 | 5.229 | |
HIP | 6145 | 0.450 | 3.350 | 3.080 | 3.148 | 0.386 | 3.601 | 3.296 | 3.372 | |
HR | 6147 | 0.272 | 3.069 | 2.839 | 2.897 | 0.234 | 3.129 | 2.890 | 2.950 | |
IMT | 6080 | 0.187 | 2.967 | 2.750 | 2.804 | 0.132 | 3.045 | 2.817 | 2.874 | |
IP | 6043 | 0.250 | 2.963 | 2.745 | 2.800 | 0.171 | 3.133 | 2.893 | 2.953 | |
IRON | 6142 | 0.193 | 3.010 | 2.788 | 2.844 | 0.186 | 3.018 | 2.795 | 2.851 | |
LDL | 6142 | 0.425 | 3.295 | 3.033 | 3.099 | 0.377 | 3.465 | 3.179 | 3.251 | |
LY | 6092 | 0.345 | 3.099 | 2.863 | 2.922 | 0.318 | 3.151 | 2.908 | 2.969 | |
MCH | 6130 | 0.778 | 4.591 | 4.134 | 4.249 | 0.774 | 4.633 | 4.170 | 4.286 | |
MCV | 6130 | 0.762 | 4.495 | 4.053 | 4.164 | 0.758 | 4.534 | 4.086 | 4.198 | |
mean BP | 6145 | 0.230 | 3.033 | 2.808 | 2.864 | 0.147 | 3.207 | 2.957 | 3.020 | |
MO | 6092 | 0.404 | 3.196 | 2.947 | 3.009 | 0.378 | 3.264 | 3.005 | 3.070 | |
NE | 6092 | 0.346 | 3.101 | 2.865 | 2.924 | 0.326 | 3.138 | 2.897 | 2.958 | |
NEO A | 5657 | 0.230 | 2.680 | 2.495 | 2.541 | 0.211 | 2.704 | 2.515 | 2.563 | |
NEO A1 | 5657 | 0.205 | 2.668 | 2.484 | 2.530 | 0.189 | 2.684 | 2.498 | 2.544 | |
NEO A2 | 5657 | 0.181 | 2.659 | 2.477 | 2.522 | 0.131 | 2.732 | 2.539 | 2.588 | |
NEO A3 | 5657 | 0.148 | 2.655 | 2.473 | 2.519 | 0.145 | 2.658 | 2.476 | 2.521 | |
NEO A4 | 5657 | 0.128 | 2.657 | 2.475 | 2.521 | 0.131 | 2.656 | 2.475 | 2.520 | |
NEO A5 | 5657 | 0.148 | 2.655 | 2.473 | 2.519 | 0.120 | 2.686 | 2.500 | 2.546 | |
NEO A6 | 5657 | 0.096 | NA | NA | NA | 0.079 | NA | NA | NA | |
NEO C | 5657 | 0.207 | 2.668 | 2.484 | 2.530 | 0.160 | 2.726 | 2.534 | 2.582 | |
NEO C1 | 5657 | 0.168 | 2.657 | 2.474 | 2.520 | 0.136 | 2.690 | 2.503 | 2.550 | |
NEO C2 | 5657 | 0.182 | 2.660 | 2.477 | 2.523 | 0.173 | 2.669 | 2.485 | 2.531 | |
NEO C3 | 5657 | 0.129 | 2.657 | 2.475 | 2.521 | 0.091 | NA | NA | NA | |
NEO C4 | 5657 | 0.118 | 2.659 | 2.477 | 2.523 | 0.098 | NA | NA | NA | |
NEO C5 | 5657 | 0.178 | 2.659 | 2.476 | 2.522 | 0.128 | 2.720 | 2.529 | 2.577 | |
NEO C6 | 5657 | 0.156 | 2.655 | 2.474 | 2.519 | 0.093 | NA | NA | NA | |
NEO E | 5657 | 0.257 | 2.699 | 2.510 | 2.557 | 0.220 | 2.748 | 2.553 | 2.602 | |
NEO E1 | 5657 | 0.191 | 2.662 | 2.479 | 2.525 | 0.189 | 2.664 | 2.481 | 2.527 | |
NEO E2 | 5657 | 0.221 | 2.675 | 2.490 | 2.536 | 0.197 | 2.702 | 2.513 | 2.561 | |
NEO E3 | 5657 | 0.211 | 2.670 | 2.486 | 2.532 | 0.146 | 2.753 | 2.558 | 2.607 | |
NEO E4 | 5657 | 0.190 | 2.662 | 2.479 | 2.525 | 0.166 | 2.686 | 2.500 | 2.547 | |
NEO E5 | 5657 | 0.157 | 2.655 | 2.474 | 2.519 | 0.115 | 2.706 | 2.518 | 2.565 | |
NEO E6 | 5657 | 0.166 | 2.656 | 2.474 | 2.520 | 0.147 | 2.675 | 2.490 | 2.536 | |
NEO N | 5657 | 0.258 | 2.700 | 2.511 | 2.558 | 0.211 | 2.776 | 2.577 | 2.627 | |
NEO N1 | 5657 | 0.180 | 2.659 | 2.476 | 2.522 | 0.145 | 2.698 | 2.510 | 2.557 | |
NEO N2 | 5657 | 0.214 | 2.672 | 2.487 | 2.533 | 0.191 | 2.699 | 2.511 | 2.558 | |
NEO N3 | 5657 | 0.247 | 2.692 | 2.504 | 2.551 | 0.210 | 2.748 | 2.553 | 2.602 | |
NEO N4 | 5657 | 0.196 | 2.664 | 2.481 | 2.526 | 0.184 | 2.677 | 2.492 | 2.538 | |
NEO N5 | 5657 | 0.144 | 2.655 | 2.474 | 2.519 | 0.101 | 2.710 | 2.521 | 2.568 | |
NEO N6 | 5657 | 0.137 | 2.656 | 2.474 | 2.519 | 0.114 | 2.676 | 2.492 | 2.538 | |
NEO O | 5657 | 0.329 | 2.769 | 2.571 | 2.621 | 0.285 | 2.872 | 2.661 | 2.713 | |
NEO O1 | 5657 | 0.218 | 2.674 | 2.489 | 2.535 | 0.205 | 2.691 | 2.504 | 2.551 | |
NEO O2 | 5657 | 0.254 | 2.696 | 2.508 | 2.555 | 0.222 | 2.743 | 2.549 | 2.598 | |
NEO O3 | 5657 | 0.153 | 2.655 | 2.473 | 2.519 | 0.131 | 2.679 | 2.494 | 2.540 | |
NEO O4 | 5657 | 0.185 | 2.661 | 2.478 | 2.523 | 0.164 | 2.684 | 2.498 | 2.544 | |
NEO O5 | 5657 | 0.267 | 2.707 | 2.517 | 2.564 | 0.241 | 2.746 | 2.551 | 2.600 | |
NEO O6 | 5657 | 0.188 | 2.661 | 2.478 | 2.524 | 0.151 | 2.704 | 2.516 | 2.563 | |
normalized PWV | 6048 | 0.191 | 2.937 | 2.723 | 2.777 | 0.194 | 2.938 | 2.724 | 2.778 | |
PLT | 6127 | 0.528 | 3.531 | 3.236 | 3.310 | 0.507 | 3.627 | 3.317 | 3.395 | |
POTASSIUM | 6142 | 0.183 | 3.007 | 2.786 | 2.841 | 0.177 | 3.014 | 2.792 | 2.848 | |
PR | 6104 | 0.285 | 3.052 | 2.823 | 2.880 | 0.273 | 3.074 | 2.842 | 2.900 | |
PSA | 2604 | 0.428 | 0.858 | 0.829 | 0.837 | 0.399 | 0.869 | 0.840 | 0.847 | |
PSV | 6044 | 0.326 | 3.043 | 2.815 | 2.872 | 0.269 | 3.181 | 2.933 | 2.995 | |
pulse pressure | 6145 | 0.208 | 3.020 | 2.797 | 2.853 | 0.127 | 3.190 | 2.943 | 3.004 | |
PWV | 6048 | 0.225 | 2.954 | 2.738 | 2.792 | 0.224 | 2.956 | 2.740 | 2.794 | |
QTC | 6147 | 0.165 | 3.008 | 2.787 | 2.842 | 0.130 | 3.051 | 2.824 | 2.881 | |
RBC | 6125 | 0.672 | 4.026 | 3.658 | 3.750 | 0.655 | 4.156 | 3.768 | 3.865 | |
SD ratio | 6041 | 0.264 | 2.973 | 2.754 | 2.809 | 0.195 | 3.116 | 2.877 | 2.937 | |
SERUM CREATININE | 6142 | 0.346 | 3.155 | 2.913 | 2.973 | 0.330 | 3.193 | 2.945 | 3.007 | |
SERUM GLUCOSE | 6142 | 0.362 | 3.180 | 2.934 | 2.995 | 0.314 | 3.302 | 3.039 | 3.104 | |
SERUM INSULIN | 5990 | 0.256 | 2.918 | 2.706 | 2.759 | 0.239 | 2.939 | 2.724 | 2.778 | |
SODIUM | 6142 | 0.253 | 3.047 | 2.820 | 2.877 | 0.254 | 3.048 | 2.820 | 2.877 | |
systolic BP | 6145 | 0.259 | 3.056 | 2.827 | 2.884 | 0.162 | 3.292 | 3.030 | 3.096 | |
TRANSFERRIN | 6142 | 0.197 | 3.011 | 2.790 | 2.845 | 0.189 | 3.022 | 2.799 | 2.855 | |
TRIGLYCERIDES | 6142 | 0.322 | 3.122 | 2.884 | 2.943 | 0.295 | 3.172 | 2.927 | 2.988 | |
TSH | 3461 | 0.384 | 1.155 | 1.114 | 1.124 | 0.373 | 1.160 | 1.118 | 1.128 | |
URIC ACID | 6142 | 0.342 | 3.150 | 2.908 | 2.968 | 0.338 | 3.158 | 2.915 | 2.976 | |
Vascular mass | 6027 | 0.300 | 3.009 | 2.784 | 2.840 | 0.246 | 3.093 | 2.857 | 2.916 | |
vti | 6043 | 0.255 | 2.966 | 2.748 | 2.803 | 0.225 | 3.011 | 2.787 | 2.843 | |
WAIST | 6145 | 0.370 | 3.197 | 2.948 | 3.010 | 0.312 | 3.387 | 3.112 | 3.181 | |
Wall Lumen | 6027 | 0.224 | 2.942 | 2.727 | 2.781 | 0.194 | 2.994 | 2.771 | 2.827 | |
WBC | 6130 | 0.384 | 3.205 | 2.955 | 3.017 | 0.329 | 3.370 | 3.097 | 3.165 | |
WEIGHT | 6144 | 0.498 | 3.466 | 3.180 | 3.251 | 0.439 | 3.770 | 3.440 | 3.522 | |
Last updated: 2006-10-23 by Wei-Min Chen