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Genome Wide Associations Scans for Total Cholesterol, HDL-C, LDL-C and triglycerides
Meta-Analysis Tables
The three tables below summarize the results of the meta-analysis described
in Teslovich et al, Nature (2010). Each table includes eight columns: the rs#
for each SNP evaluated, the two alleles of the SNP in genome-build 36, the
number of individuals evaluated for this SNP, the combined z-statistic for
the SNP, the combined p-value for each SNP, the overall direction of effect
(a positive statistic indicates allele 1 was associated with increased
trait values), and a summary of the observed direction
effect in each study contributing to the meta-analysis. The files included both genotyped
and imputed SNPs and are provided in a compressed text file to conserve space. Further annotation of
file contents is available at the bottom of this webpage
Update: Tables that also include effect size estimates, in standard deviation
units, for each variant are now also available for download. Please note that these files
are quite a bit larger (about 40%).
RESULT FILES
Total Cholesterol Meta-Analysis Results TC2010.zip TC_with_Effect.zip
HDL-C Meta-Analysis Results HDL2010.zip HDL_with_Effect.zip
LDL-C Meta-Analysis Results LDL2010.zip LDL_with_Effect.zip
Triglycerides Meta-Analysis Results TG2010.zip TG_with_Effect.zip
Results for our previous meta-analyses are also available online, see
Kathiresan et al, 2009 results and
Willer et al, 2008 results.
Columns in Result Files
| Column Label | Description |
| Marker | This is the marker name. |
| Allele1 | This the allele used as the effect allele. |
| Allele2 | This is the "other" allele. |
| Weight | The sum of the individual study weights (typically, N) for this marker. |
| GC.Zscore | The combined z-statistic for this marker, after genomic control correction. |
| GC.Pvalue | Meta-analysis p-value, after genomic control correction. |
| Overall | Overall direction of effect. Positive values indicate allele1 raises trait values. |
| Direction | Summary of effect direction for each study, with one '+', '-' or '=' per study. Missing values labeled as '?'. |
| Effect | Effect size estimates in standard deviation units. |
| StdErr | Standard error for effect size estiamtes. |
Order of studies for Direction of Effect Information
Full study descriptions are available in Online Supplementary Material for the Main Paper. The "Direction" column refers to studies in the following order:
| STUDY No. | Label |
| Study 1 | AGES |
| Study 2 | ARIC |
| Study 3 | KORA |
| Study 4 | Framingham Heart Study |
| Study 5 | FUSION (Meta-analysis of T2D cases and controls) |
| Study 6 | B58C-T1DGC |
| Study 7 | B58C-WTCCC |
| Study 8 | COLAUS |
| Study 9 | EPIC_N_OBSET |
| Study 10 | EPIC_N_SUBCOH |
| Study 11 | FENLAND |
| Study 12 | WGHS |
| Study 13 | BRIGHT |
| Study 14 | ENGAGE (Meta-analysis of FINRISK, NFBC66, RS-I, RS-II, GENMETS, ERF, MICROS, NSPHS, ORCADES, Vis, and six twin studies) |
| Study 15 | PARC |
| Study 16 | CHS |
| Study 17 | BLSA |
| Study 18 | InCHIANTI |
| Study 19 | SardiNIA |
| Study 20 | SuViMax |
| Study 21 | MEDSTAR (Meta-analysis of myocardial infarction cases and controls) |
| Study 22 | PENNCATH (Meta-analysis of myocardial infarction cases and controls) |
| Study 23 | LOLIPOP |
| Study 24 | DGI (Meta-analysis of T2D cases and controls) |
| Study 25 | Family Heart Study |
Please e-mail Goncalo Abecasis or
Tanya Teslovich with comments or
suggestions.
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