Looking at both over and under enriched genes by decile.

For this report, the genes in deciles were called as differentially expressed.

This report was last generated on Thu Jun 04 08:10:10 AM 2015

1

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Number of significant over represented GO categories: 443

Number of significant under represented GO categories: 147

Number of DE genes: 1671

category term numInCat numDEInCat q.value
GO:0006954 inflammatory response 475 110 0.0000000
GO:0050896 response to stimulus 6127 738 0.0000000
GO:0001775 cell activation 767 148 0.0000000
GO:0006955 immune response 1140 193 0.0000000
GO:0045321 leukocyte activation 561 118 0.0000000
GO:0002376 immune system process 1939 289 0.0000000
GO:0009605 response to external stimulus 1592 249 0.0000000
GO:0006952 defense response 1181 196 0.0000000
GO:0044707 single-multicellular organism process 4822 595 0.0000000
GO:0032501 multicellular organismal process 4965 609 0.0000000
GO:0023052 signaling 4498 557 0.0000000
GO:0044700 single organism signaling 4498 557 0.0000000
GO:0007154 cell communication 4561 561 0.0000000
GO:0009611 response to wounding 834 145 0.0000000
GO:0002682 regulation of immune system process 998 164 0.0000000
GO:0007166 cell surface receptor signaling pathway 2373 325 0.0000000
GO:0002274 myeloid leukocyte activation 123 40 0.0000000
GO:0050900 leukocyte migration 271 64 0.0000000
GO:0007165 signal transduction 4078 505 0.0000000
GO:0046649 lymphocyte activation 480 95 0.0000000
GO:0042110 T cell activation 347 76 0.0000000
GO:0048731 system development 3249 418 0.0000000
GO:0050865 regulation of cell activation 366 78 0.0000000
GO:0040011 locomotion 1248 193 0.0000000
GO:0006935 chemotaxis 559 105 0.0000000
GO:0042330 taxis 559 105 0.0000000
GO:0044763 single-organism cellular process 9512 1020 0.0000000
GO:0022610 biological adhesion 920 153 0.0000000
GO:0044699 single-organism process 10473 1101 0.0000000
GO:0007155 cell adhesion 916 152 0.0000000
GO:0002521 leukocyte differentiation 353 75 0.0000000
GO:0002694 regulation of leukocyte activation 340 72 0.0000000
GO:0007186 G-protein coupled receptor signaling pathway 548 100 0.0000000
GO:0050776 regulation of immune response 667 116 0.0000000
GO:0032101 regulation of response to external stimulus 502 93 0.0000000
GO:0030098 lymphocyte differentiation 235 56 0.0000000
GO:0002684 positive regulation of immune system process 611 107 0.0000000
GO:0051716 cellular response to stimulus 4976 580 0.0000000
GO:0030154 cell differentiation 2703 346 0.0000001
GO:0016477 cell migration 888 140 0.0000001
GO:0048856 anatomical structure development 3826 463 0.0000001
GO:0048583 regulation of response to stimulus 2707 345 0.0000002
GO:0065008 regulation of biological quality 2577 329 0.0000002
GO:0030595 leukocyte chemotaxis 130 35 0.0000002
GO:0042221 response to chemical 2788 349 0.0000002
GO:0007275 multicellular organismal development 3706 449 0.0000002
GO:0048870 cell motility 949 146 0.0000003
GO:0051674 localization of cell 949 146 0.0000003
GO:0048584 positive regulation of response to stimulus 1325 189 0.0000003
GO:0030217 T cell differentiation 167 43 0.0000003
GO:2000026 regulation of multicellular organismal development 1141 169 0.0000003
GO:0006928 cellular component movement 1406 200 0.0000003
GO:1903034 regulation of response to wounding 292 60 0.0000004
GO:0060326 cell chemotaxis 178 42 0.0000004
GO:0051239 regulation of multicellular organismal process 1820 243 0.0000007
GO:0048869 cellular developmental process 2893 360 0.0000011
GO:0050778 positive regulation of immune response 442 80 0.0000011
GO:0050863 regulation of T cell activation 226 49 0.0000017
GO:0050870 positive regulation of T cell activation 165 40 0.0000019
GO:0097529 myeloid leukocyte migration 104 29 0.0000020
GO:0002252 immune effector process 504 86 0.0000020
GO:0051249 regulation of lymphocyte activation 298 59 0.0000021
GO:0045058 T cell selection 34 16 0.0000030
GO:0050727 regulation of inflammatory response 212 46 0.0000031
GO:0048513 organ development 2335 296 0.0000032
GO:0002253 activation of immune response 374 70 0.0000033
GO:0032502 developmental process 4293 499 0.0000040
GO:0044767 single-organism developmental process 4248 494 0.0000046
GO:0006811 ion transport 1118 159 0.0000051
GO:0002696 positive regulation of leukocyte activation 230 48 0.0000061
GO:0009607 response to biotic stimulus 567 91 0.0000069
GO:0097530 granulocyte migration 71 22 0.0000071
GO:0050867 positive regulation of cell activation 239 49 0.0000077
GO:0043207 response to external biotic stimulus 537 87 0.0000079
GO:0051707 response to other organism 537 87 0.0000079
GO:1902105 regulation of leukocyte differentiation 178 41 0.0000087
GO:0048534 hematopoietic or lymphoid organ development 615 99 0.0000110
GO:0098542 defense response to other organism 272 52 0.0000164
GO:0050878 regulation of body fluid levels 578 94 0.0000170
GO:0002697 regulation of immune effector process 231 47 0.0000219
GO:1902531 regulation of intracellular signal transduction 1317 181 0.0000227
GO:0032940 secretion by cell 682 105 0.0000254
GO:0032103 positive regulation of response to external stimulus 169 37 0.0000295
GO:0046903 secretion 769 115 0.0000314
GO:0051251 positive regulation of lymphocyte activation 212 44 0.0000333
GO:0016337 single organismal cell-cell adhesion 285 55 0.0000345
GO:0030155 regulation of cell adhesion 299 57 0.0000369
GO:0045619 regulation of lymphocyte differentiation 104 28 0.0000373
GO:0042060 wound healing 596 95 0.0000387
GO:0071621 granulocyte chemotaxis 67 20 0.0000415
GO:0019835 cytolysis 23 11 0.0000418
GO:0030097 hemopoiesis 587 93 0.0000447
GO:0009617 response to bacterium 300 54 0.0000478
GO:0002520 immune system development 648 100 0.0000550
GO:0031347 regulation of defense response 463 76 0.0000604
GO:0002429 immune response-activating cell surface receptor signaling pathway 204 43 0.0000692
GO:1990266 neutrophil migration 57 18 0.0000723
GO:0002820 negative regulation of adaptive immune response 17 10 0.0000905
GO:0002443 leukocyte mediated immunity 211 42 0.0001086
GO:0042742 defense response to bacterium 103 25 0.0001241
category term numInCat numDEInCat q.value2
8666 GO:0006396 RNA processing 676 6 0.0000000
8884 GO:0010467 gene expression 4325 281 0.0000000
8980 GO:0016070 RNA metabolic process 3695 231 0.0000000
8981 GO:0016071 mRNA metabolic process 615 3 0.0000000
9491 GO:0043170 macromolecule metabolic process 7144 536 0.0000000
9530 GO:0044260 cellular macromolecule metabolic process 6487 443 0.0000000
10128 GO:0090304 nucleic acid metabolic process 4168 258 0.0000000
10332 GO:0034645 cellular macromolecule biosynthetic process 3922 260 0.0000000
10333 GO:0044265 cellular macromolecule catabolic process 798 22 0.0000000
10334 GO:0006397 mRNA processing 404 3 0.0000000
10335 GO:0006139 nucleobase-containing compound metabolic process 5434 395 0.0000000
10336 GO:0044237 cellular metabolic process 8655 697 0.0000000
10337 GO:0070647 protein modification by small protein conjugation or removal 731 20 0.0000000
10339 GO:0046483 heterocycle metabolic process 5564 408 0.0000000
10342 GO:0008380 RNA splicing 332 1 0.0000000
10344 GO:0009059 macromolecule biosynthetic process 4027 275 0.0000000
10351 GO:0006725 cellular aromatic compound metabolic process 5569 412 0.0000000
10356 GO:1901360 organic cyclic compound metabolic process 5728 427 0.0000000
10364 GO:0034641 cellular nitrogen compound metabolic process 5753 430 0.0000000
10471 GO:0016567 protein ubiquitination 612 16 0.0000000
10585 GO:0006807 nitrogen compound metabolic process 6074 465 0.0000000
10606 GO:0071704 organic substance metabolic process 8973 741 0.0000000
10620 GO:0032446 protein modification by small protein conjugation 654 19 0.0000000
11278 GO:0044238 primary metabolic process 8723 720 0.0000000
11536 GO:0044267 cellular protein metabolic process 3491 240 0.0000000
8672 GO:0006412 translation 496 10 0.0000000
9322 GO:0034660 ncRNA metabolic process 325 3 0.0000000
8444 GO:0000375 RNA splicing, via transesterification reactions 225 0 0.0000001
8445 GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 220 0 0.0000001
8452 GO:0000398 mRNA splicing, via spliceosome 220 0 0.0000001
6835 GO:1901576 organic substance biosynthetic process 4832 362 0.0000002
6834 GO:0044249 cellular biosynthetic process 4759 356 0.0000002
6831 GO:0008152 metabolic process 9727 828 0.0000008
6832 GO:0006974 cellular response to DNA damage stimulus 668 24 0.0000009
6829 GO:0009058 biosynthetic process 4901 372 0.0000009
6833 GO:0022613 ribonucleoprotein complex biogenesis 280 3 0.0000014
6825 GO:2000112 regulation of cellular macromolecule biosynthetic process 3131 220 0.0000014
8433 GO:0000209 protein polyubiquitination 187 0 0.0000018
8669 GO:0006402 mRNA catabolic process 196 0 0.0000018
6830 GO:0043632 modification-dependent macromolecule catabolic process 437 12 0.0000021
6823 GO:0010556 regulation of macromolecule biosynthetic process 3216 228 0.0000021
6826 GO:0051276 chromosome organization 738 31 0.0000021
6828 GO:0019941 modification-dependent protein catabolic process 433 12 0.0000027
6822 GO:0070727 cellular macromolecule localization 1129 58 0.0000028
6821 GO:0034613 cellular protein localization 1124 58 0.0000036
6818 GO:0018130 heterocycle biosynthetic process 3414 246 0.0000047
6824 GO:0006511 ubiquitin-dependent protein catabolic process 424 12 0.0000047
8468 GO:0000956 nuclear-transcribed mRNA catabolic process 184 0 0.0000052
6816 GO:0032774 RNA biosynthetic process 3065 217 0.0000057
6815 GO:0044271 cellular nitrogen compound biosynthetic process 3464 251 0.0000062
6812 GO:0019438 aromatic compound biosynthetic process 3412 247 0.0000069
6820 GO:0051603 proteolysis involved in cellular protein catabolic process 470 15 0.0000071
6817 GO:0009057 macromolecule catabolic process 983 49 0.0000072
6827 GO:0034470 ncRNA processing 235 2 0.0000074
6819 GO:0044257 cellular protein catabolic process 485 16 0.0000075
6809 GO:0034654 nucleobase-containing compound biosynthetic process 3351 243 0.0000100
6813 GO:0016568 chromatin modification 502 18 0.0000126
6814 GO:0016569 covalent chromatin modification 348 9 0.0000160
6808 GO:0006886 intracellular protein transport 758 34 0.0000180
6806 GO:1901362 organic cyclic compound biosynthetic process 3505 258 0.0000194
6810 GO:0006281 DNA repair 393 11 0.0000205
6807 GO:0006325 chromatin organization 563 22 0.0000213
6811 GO:0016570 histone modification 343 9 0.0000220
6804 GO:0010468 regulation of gene expression 3468 258 0.0000318
6802 GO:0051252 regulation of RNA metabolic process 2968 215 0.0000350
6800 GO:0006351 transcription, DNA-templated 2954 214 0.0000410
6799 GO:0009889 regulation of biosynthetic process 3370 250 0.0000452
6798 GO:0031326 regulation of cellular biosynthetic process 3343 249 0.0000685
6797 GO:2001141 regulation of RNA biosynthetic process 2890 210 0.0000694
6794 GO:0006355 regulation of transcription, DNA-templated 2853 209 0.0001449
6795 GO:0046907 intracellular transport 1406 86 0.0001462
6803 GO:0006401 RNA catabolic process 222 3 0.0001668
6796 GO:0033365 protein localization to organelle 603 26 0.0001778
6805 GO:0042254 ribosome biogenesis 167 1 0.0002583
6801 GO:0006413 translational initiation 167 1 0.0004211
6788 GO:0016482 cytoplasmic transport 825 44 0.0007810
6791 GO:0007005 mitochondrion organization 298 8 0.0009079
6786 GO:0030163 protein catabolic process 596 29 0.0010623
6790 GO:0010498 proteasomal protein catabolic process 284 8 0.0010656
6789 GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process 265 7 0.0011347
6782 GO:0060255 regulation of macromolecule metabolic process 4403 353 0.0013164
6778 GO:0043412 macromolecule modification 2854 218 0.0015826
8673 GO:0006414 translational elongation 121 0 0.0019676
6793 GO:0006399 tRNA metabolic process 142 1 0.0020076
6792 GO:0051168 nuclear export 136 1 0.0021140
8431 GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay 118 0 0.0022413
6771 GO:1902582 single-organism intracellular transport 1181 74 0.0028806
6781 GO:0090150 establishment of protein localization to membrane 296 9 0.0032696
6787 GO:0006403 RNA localization 151 2 0.0033950
6768 GO:0006259 DNA metabolic process 838 48 0.0040480
6765 GO:0006996 organelle organization 2485 187 0.0041427
6762 GO:0019538 protein metabolic process 4124 332 0.0049934
6757 GO:0006464 cellular protein modification process 2739 213 0.0059200
6758 GO:0036211 protein modification process 2739 213 0.0059200
6773 GO:0031396 regulation of protein ubiquitination 209 5 0.0059200
6783 GO:0050657 nucleic acid transport 144 2 0.0059200
6784 GO:0050658 RNA transport 144 2 0.0059200
6785 GO:0051236 establishment of RNA localization 144 2 0.0059200
8714 GO:0006613 cotranslational protein targeting to membrane 109 0 0.0059200
9550 GO:0045047 protein targeting to ER 110 0 0.0059200

2

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Number of significant over represented GO categories: 23

Number of significant under represented GO categories: 101

Number of DE genes: 1672

category term numInCat numDEInCat q.value
GO:0023052 signaling 4498 541 0.0000001
GO:0044700 single organism signaling 4498 541 0.0000001
GO:0007154 cell communication 4561 547 0.0000001
GO:0007165 signal transduction 4078 482 0.0000234
GO:0050896 response to stimulus 6127 681 0.0000255
GO:0006952 defense response 1181 160 0.0003755
GO:0044763 single-organism cellular process 9512 990 0.0009557
GO:0044707 single-multicellular organism process 4822 542 0.0009805
GO:0032501 multicellular organismal process 4965 556 0.0009805
GO:0065008 regulation of biological quality 2577 312 0.0011616
GO:0007267 cell-cell signaling 913 130 0.0012985
GO:0009605 response to external stimulus 1592 204 0.0014427
GO:0044699 single-organism process 10473 1074 0.0018965
GO:0007166 cell surface receptor signaling pathway 2373 290 0.0021915
GO:0051716 cellular response to stimulus 4976 553 0.0038525
GO:0009611 response to wounding 834 117 0.0091785
GO:0044767 single-organism developmental process 4248 478 0.0137132
GO:0032502 developmental process 4293 482 0.0147283
GO:0048584 positive regulation of response to stimulus 1325 170 0.0147772
GO:0007155 cell adhesion 916 126 0.0301746
GO:0022610 biological adhesion 920 126 0.0355024
GO:0006954 inflammatory response 475 69 0.0407391
GO:0010226 response to lithium ion 18 8 0.0495427
category term numInCat numDEInCat q.value2
8763 GO:0010467 gene expression 4325 272 0.0000000
8876 GO:0016070 RNA metabolic process 3695 213 0.0000000
9237 GO:0034645 cellular macromolecule biosynthetic process 3922 250 0.0000000
9469 GO:0044260 cellular macromolecule metabolic process 6487 455 0.0000000
10084 GO:0090304 nucleic acid metabolic process 4168 243 0.0000000
10312 GO:0006139 nucleobase-containing compound metabolic process 5434 387 0.0000000
10313 GO:0009059 macromolecule biosynthetic process 4027 265 0.0000000
10314 GO:0006725 cellular aromatic compound metabolic process 5569 402 0.0000000
10315 GO:0043170 macromolecule metabolic process 7144 547 0.0000000
10316 GO:0046483 heterocycle metabolic process 5564 401 0.0000000
10317 GO:1901360 organic cyclic compound metabolic process 5728 421 0.0000000
10318 GO:0034641 cellular nitrogen compound metabolic process 5753 425 0.0000000
10333 GO:0032774 RNA biosynthetic process 3065 197 0.0000000
10367 GO:0006396 RNA processing 676 18 0.0000000
10675 GO:0044237 cellular metabolic process 8655 713 0.0000000
10843 GO:2000112 regulation of cellular macromolecule biosynthetic process 3131 209 0.0000000
10867 GO:0006807 nitrogen compound metabolic process 6074 469 0.0000000
10956 GO:0010556 regulation of macromolecule biosynthetic process 3216 216 0.0000000
11637 GO:0044238 primary metabolic process 8723 724 0.0000000
11817 GO:0006351 transcription, DNA-templated 2954 196 0.0000000
8877 GO:0016071 mRNA metabolic process 615 18 0.0000000
8938 GO:0019438 aromatic compound biosynthetic process 3412 237 0.0000000
6608 GO:0044249 cellular biosynthetic process 4759 357 0.0000002
6607 GO:0018130 heterocycle biosynthetic process 3414 239 0.0000002
6605 GO:1901362 organic cyclic compound biosynthetic process 3505 247 0.0000002
6606 GO:0051252 regulation of RNA metabolic process 2968 203 0.0000002
6602 GO:0071704 organic substance metabolic process 8973 757 0.0000003
6604 GO:2001141 regulation of RNA biosynthetic process 2890 197 0.0000003
6603 GO:0034654 nucleobase-containing compound biosynthetic process 3351 235 0.0000003
6601 GO:1901576 organic substance biosynthetic process 4832 365 0.0000003
6600 GO:0010468 regulation of gene expression 3468 247 0.0000003
6599 GO:0006355 regulation of transcription, DNA-templated 2853 195 0.0000004
6598 GO:0009058 biosynthetic process 4901 375 0.0000014
6597 GO:0016482 cytoplasmic transport 825 36 0.0000031
6596 GO:0044267 cellular protein metabolic process 3491 254 0.0000035
6595 GO:0044271 cellular nitrogen compound biosynthetic process 3464 252 0.0000069
6594 GO:0031326 regulation of cellular biosynthetic process 3343 244 0.0000098
6589 GO:0009889 regulation of biosynthetic process 3370 248 0.0000196
6588 GO:0006366 transcription from RNA polymerase II promoter 1448 87 0.0000266
6591 GO:0006412 translation 496 16 0.0000321
6590 GO:0006397 mRNA processing 404 12 0.0000390
6593 GO:0034660 ncRNA metabolic process 325 7 0.0000390
6586 GO:0060255 regulation of macromolecule metabolic process 4403 342 0.0000421
6592 GO:0022613 ribonucleoprotein complex biogenesis 280 5 0.0000488
6587 GO:0006325 chromatin organization 563 23 0.0000581
6583 GO:0008152 metabolic process 9727 848 0.0001091
6585 GO:0051276 chromosome organization 738 36 0.0001125
6581 GO:0044265 cellular macromolecule catabolic process 798 40 0.0001919
6584 GO:0008380 RNA splicing 332 9 0.0002060
6580 GO:0016568 chromatin modification 502 21 0.0002324
6582 GO:0007005 mitochondrion organization 298 7 0.0003392
6577 GO:0019219 regulation of nucleobase-containing compound metabolic process 3670 286 0.0003981
6579 GO:0033365 protein localization to organelle 603 27 0.0005262
6578 GO:0070647 protein modification by small protein conjugation or removal 731 38 0.0005610
6572 GO:0051171 regulation of nitrogen compound metabolic process 3755 297 0.0011958
6570 GO:0031323 regulation of cellular metabolic process 4753 388 0.0014650
6575 GO:0034470 ncRNA processing 235 5 0.0018443
6567 GO:0043412 macromolecule modification 2854 219 0.0019149
6568 GO:0006357 regulation of transcription from RNA polymerase II promoter 1306 85 0.0021017
6571 GO:0006511 ubiquitin-dependent protein catabolic process 424 18 0.0023757
6576 GO:0042254 ribosome biogenesis 167 2 0.0028131
6563 GO:0009057 macromolecule catabolic process 983 59 0.0031841
6566 GO:0072594 establishment of protein localization to organelle 456 19 0.0031841
6574 GO:0006413 translational initiation 167 2 0.0044104
6565 GO:0016569 covalent chromatin modification 348 14 0.0044619
6573 GO:0000956 nuclear-transcribed mRNA catabolic process 184 3 0.0047723
6569 GO:0006401 RNA catabolic process 222 5 0.0049054
6561 GO:0043632 modification-dependent macromolecule catabolic process 437 20 0.0057602
6559 GO:0046907 intracellular transport 1406 94 0.0057868
6562 GO:0016570 histone modification 343 14 0.0057868
6560 GO:0019941 modification-dependent protein catabolic process 433 20 0.0071131
6564 GO:0006402 mRNA catabolic process 196 4 0.0077499
9908 GO:0070646 protein modification by small protein removal 93 0 0.0080042
6558 GO:0006974 cellular response to DNA damage stimulus 668 36 0.0086301
6555 GO:0006464 cellular protein modification process 2739 215 0.0091227
6556 GO:0036211 protein modification process 2739 215 0.0091227
6549 GO:0019538 protein metabolic process 4124 336 0.0108000
6552 GO:1902582 single-organism intracellular transport 1181 77 0.0112626
6550 GO:0006259 DNA metabolic process 838 50 0.0132374
6553 GO:0016567 protein ubiquitination 612 34 0.0132374
6551 GO:0006886 intracellular protein transport 758 44 0.0133019
6546 GO:0010558 negative regulation of macromolecule biosynthetic process 959 61 0.0147715
6541 GO:0006996 organelle organization 2485 192 0.0154686
6554 GO:0051169 nuclear transport 363 16 0.0154686
6545 GO:1902680 positive regulation of RNA biosynthetic process 1030 67 0.0162623
6544 GO:2000113 negative regulation of cellular macromolecule biosynthetic process 914 58 0.0167628
8987 GO:0022900 electron transport chain 106 0 0.0167628
6538 GO:0051254 positive regulation of RNA metabolic process 1050 69 0.0182328
8988 GO:0022904 respiratory electron transport chain 105 0 0.0182984
6548 GO:0006913 nucleocytoplasmic transport 359 16 0.0183736
6543 GO:0032446 protein modification by small protein conjugation 654 38 0.0190331
6557 GO:0016197 endosomal transport 188 5 0.0191873
6542 GO:0006605 protein targeting 497 25 0.0212467
8900 GO:0016579 protein deubiquitination 80 0 0.0243818
6529 GO:0080090 regulation of primary metabolic process 4733 399 0.0247071
6531 GO:0010557 positive regulation of macromolecule biosynthetic process 1169 79 0.0247071
6547 GO:0000375 RNA splicing, via transesterification reactions 225 7 0.0247071
6530 GO:0051603 proteolysis involved in cellular protein catabolic process 470 25 0.0325726
6539 GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 220 7 0.0325726
6540 GO:0000398 mRNA splicing, via spliceosome 220 7 0.0325726

3

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Number of significant over represented GO categories: 15

Number of significant under represented GO categories: 5

Number of DE genes: 1670

category term numInCat numDEInCat q.value
GO:0006955 immune response 1140 146 0.0391179
GO:0007431 salivary gland development 36 13 0.0391179
GO:0040012 regulation of locomotion 533 80 0.0391179
GO:0000902 cell morphogenesis 993 136 0.0391179
GO:2000145 regulation of cell motility 492 75 0.0391179
GO:0030334 regulation of cell migration 468 72 0.0391179
GO:0007435 salivary gland morphogenesis 32 12 0.0391179
GO:0030166 proteoglycan biosynthetic process 49 15 0.0391179
GO:0060337 type I interferon signaling pathway 64 17 0.0391179
GO:0071357 cellular response to type I interferon 64 17 0.0391179
GO:0051270 regulation of cellular component movement 555 82 0.0391179
GO:0006928 cellular component movement 1406 178 0.0391179
GO:0034340 response to type I interferon 65 17 0.0445711
GO:0014031 mesenchymal cell development 121 26 0.0445711
GO:0002252 immune effector process 504 73 0.0486598
category term numInCat numDEInCat q.value2
6553 GO:0006412 translation 496 18 0.0161868
6551 GO:0051276 chromosome organization 738 39 0.0412220
6549 GO:0006396 RNA processing 676 34 0.0478389
6550 GO:0022613 ribonucleoprotein complex biogenesis 280 8 0.0478389
6552 GO:0042254 ribosome biogenesis 167 2 0.0478389

4

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Number of significant over represented GO categories: 0

Number of significant under represented GO categories: 0

Number of DE genes: 1671

category term numInCat numDEInCat q.value
GO:0060271 cilium morphogenesis 154 30 1
category term numInCat numDEInCat q.value2
6503 GO:0003012 muscle system process 299 10 0.8413186

5

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Number of significant over represented GO categories: 1

Number of significant under represented GO categories: 0

Number of DE genes: 1672

category term numInCat numDEInCat q.value
GO:0006397 mRNA processing 404 67 0.0299188
category term numInCat numDEInCat q.value2
6428 GO:0006811 ion transport 1118 69 0.2363159

6

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Number of significant over represented GO categories: 36

Number of significant under represented GO categories: 3

Number of DE genes: 1670

category term numInCat numDEInCat q.value
GO:0010467 gene expression 4325 506 0.0000041
GO:0090304 nucleic acid metabolic process 4168 486 0.0000093
GO:0044260 cellular macromolecule metabolic process 6487 712 0.0000093
GO:0034645 cellular macromolecule biosynthetic process 3922 461 0.0000093
GO:0009059 macromolecule biosynthetic process 4027 470 0.0000113
GO:0016070 RNA metabolic process 3695 432 0.0000458
GO:0044249 cellular biosynthetic process 4759 531 0.0002553
GO:1901576 organic substance biosynthetic process 4832 537 0.0002871
GO:0009058 biosynthetic process 4901 541 0.0009321
GO:0043170 macromolecule metabolic process 7144 756 0.0009321
GO:0032774 RNA biosynthetic process 3065 359 0.0010526
GO:0006351 transcription, DNA-templated 2954 345 0.0056668
GO:0010468 regulation of gene expression 3468 397 0.0056668
GO:2000112 regulation of cellular macromolecule biosynthetic process 3131 362 0.0074754
GO:0010556 regulation of macromolecule biosynthetic process 3216 370 0.0074754
GO:0006139 nucleobase-containing compound metabolic process 5434 586 0.0099453
GO:0006725 cellular aromatic compound metabolic process 5569 597 0.0145191
GO:0051276 chromosome organization 738 105 0.0145191
GO:0044238 primary metabolic process 8723 893 0.0150288
GO:0009889 regulation of biosynthetic process 3370 381 0.0196765
GO:0006355 regulation of transcription, DNA-templated 2853 329 0.0222411
GO:0046483 heterocycle metabolic process 5564 594 0.0222411
GO:2001141 regulation of RNA biosynthetic process 2890 332 0.0224347
GO:0051252 regulation of RNA metabolic process 2968 340 0.0224347
GO:0071704 organic substance metabolic process 8973 913 0.0224347
GO:0031326 regulation of cellular biosynthetic process 3343 377 0.0224347
GO:0034641 cellular nitrogen compound metabolic process 5753 611 0.0224347
GO:0006396 RNA processing 676 94 0.0224347
GO:1901360 organic cyclic compound metabolic process 5728 608 0.0241956
GO:0006259 DNA metabolic process 838 112 0.0248718
GO:1901362 organic cyclic compound biosynthetic process 3505 390 0.0275035
GO:0044237 cellular metabolic process 8655 881 0.0299959
GO:0019438 aromatic compound biosynthetic process 3412 380 0.0332893
GO:0034654 nucleobase-containing compound biosynthetic process 3351 374 0.0332893
GO:0018130 heterocycle biosynthetic process 3414 379 0.0428340
GO:0006325 chromatin organization 563 81 0.0468748
category term numInCat numDEInCat q.value2
6094 GO:0032501 multicellular organismal process 4965 384 0.0012752
6095 GO:0044707 single-multicellular organism process 4822 371 0.0012752
6093 GO:0043269 regulation of ion transport 403 15 0.0344854

7

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Number of significant over represented GO categories: 39

Number of significant under represented GO categories: 34

Number of DE genes: 1672

category term numInCat numDEInCat q.value
GO:0044260 cellular macromolecule metabolic process 6487 745 0.0000001
GO:0090304 nucleic acid metabolic process 4168 511 0.0000001
GO:0044265 cellular macromolecule catabolic process 798 134 0.0000002
GO:0016070 RNA metabolic process 3695 454 0.0000009
GO:0006139 nucleobase-containing compound metabolic process 5434 629 0.0000016
GO:0043170 macromolecule metabolic process 7144 791 0.0000065
GO:0046483 heterocycle metabolic process 5564 636 0.0000075
GO:0009057 macromolecule catabolic process 983 149 0.0000084
GO:0006725 cellular aromatic compound metabolic process 5569 635 0.0000093
GO:1901360 organic cyclic compound metabolic process 5728 648 0.0000185
GO:0010467 gene expression 4325 505 0.0000247
GO:0034641 cellular nitrogen compound metabolic process 5753 649 0.0000247
GO:0006396 RNA processing 676 106 0.0000964
GO:0006807 nitrogen compound metabolic process 6074 675 0.0001194
GO:0016071 mRNA metabolic process 615 96 0.0003243
GO:0044257 cellular protein catabolic process 485 79 0.0028727
GO:0044238 primary metabolic process 8723 920 0.0036298
GO:0044237 cellular metabolic process 8655 911 0.0062477
GO:0034660 ncRNA metabolic process 325 55 0.0087968
GO:0051603 proteolysis involved in cellular protein catabolic process 470 75 0.0087968
GO:0000956 nuclear-transcribed mRNA catabolic process 184 36 0.0087968
GO:0019941 modification-dependent protein catabolic process 433 70 0.0111530
GO:0034645 cellular macromolecule biosynthetic process 3922 446 0.0124259
GO:0043632 modification-dependent macromolecule catabolic process 437 70 0.0140222
GO:0006402 mRNA catabolic process 196 37 0.0142725
GO:0030163 protein catabolic process 596 89 0.0156920
GO:0006508 proteolysis 1110 147 0.0156920
GO:0006511 ubiquitin-dependent protein catabolic process 424 68 0.0156920
GO:0006401 RNA catabolic process 222 40 0.0178783
GO:0009059 macromolecule biosynthetic process 4027 454 0.0178783
GO:0071704 organic substance metabolic process 8973 935 0.0201187
GO:0070647 protein modification by small protein conjugation or removal 731 104 0.0232710
GO:0044267 cellular protein metabolic process 3491 399 0.0241649
GO:0070979 protein K11-linked ubiquitination 26 10 0.0241842
GO:0000209 protein polyubiquitination 187 35 0.0384652
GO:0019080 viral gene expression 168 31 0.0386303
GO:0016072 rRNA metabolic process 122 25 0.0460460
GO:0006281 DNA repair 393 61 0.0462672
GO:0006974 cellular response to DNA damage stimulus 668 93 0.0464024
category term numInCat numDEInCat q.value2
6007 GO:0007155 cell adhesion 916 44 0.0000356
6008 GO:0022610 biological adhesion 920 44 0.0000356
6006 GO:0007154 cell communication 4561 361 0.0013844
6004 GO:0023052 signaling 4498 357 0.0014061
6005 GO:0044700 single organism signaling 4498 357 0.0014061
6002 GO:0048731 system development 3249 246 0.0014337
6003 GO:0006928 cellular component movement 1406 88 0.0014337
6000 GO:0044707 single-multicellular organism process 4822 390 0.0034903
6001 GO:0061061 muscle structure development 471 19 0.0034903
5998 GO:0032501 multicellular organismal process 4965 404 0.0034908
5999 GO:0007275 multicellular organismal development 3706 291 0.0034908
5997 GO:0007399 nervous system development 1657 114 0.0042795
5994 GO:0050896 response to stimulus 6127 516 0.0113953
5995 GO:0050877 neurological system process 627 32 0.0143616
5992 GO:0048856 anatomical structure development 3826 308 0.0144826
5993 GO:0009605 response to external stimulus 1592 108 0.0144826
5996 GO:0042692 muscle cell differentiation 280 9 0.0165802
5991 GO:0007267 cell-cell signaling 913 55 0.0240514
5990 GO:0030182 neuron differentiation 971 62 0.0253749
5983 GO:0044767 single-organism developmental process 4248 351 0.0351526
5984 GO:0032502 developmental process 4293 355 0.0351526
5987 GO:0007165 signal transduction 4078 334 0.0351526
5989 GO:0061564 axon development 487 25 0.0351526
5985 GO:0040011 locomotion 1248 84 0.0366410
5981 GO:0048870 cell motility 949 60 0.0415365
5982 GO:0051674 localization of cell 949 60 0.0415365
5988 GO:0030029 actin filament-based process 507 26 0.0415365
5978 GO:0048699 generation of neurons 1056 71 0.0438908
5980 GO:0032989 cellular component morphogenesis 1059 71 0.0438908
5971 GO:0048513 organ development 2335 179 0.0450682
5977 GO:0000902 cell morphogenesis 993 66 0.0450682
5979 GO:0032990 cell part morphogenesis 718 44 0.0450682
5973 GO:0022008 neurogenesis 1123 77 0.0456592
5986 GO:0060537 muscle tissue development 303 12 0.0456592

8

plot of chunk unnamed-chunk-29

Number of significant over represented GO categories: 84

Number of significant under represented GO categories: 44

Number of DE genes: 1671

category term numInCat numDEInCat q.value
GO:0046483 heterocycle metabolic process 5564 662 0.0000000
GO:0034641 cellular nitrogen compound metabolic process 5753 680 0.0000000
GO:0044237 cellular metabolic process 8655 951 0.0000000
GO:0006725 cellular aromatic compound metabolic process 5569 659 0.0000000
GO:1901360 organic cyclic compound metabolic process 5728 673 0.0000000
GO:0006412 translation 496 99 0.0000000
GO:0006139 nucleobase-containing compound metabolic process 5434 640 0.0000000
GO:0006807 nitrogen compound metabolic process 6074 702 0.0000000
GO:0090304 nucleic acid metabolic process 4168 504 0.0000000
GO:0034660 ncRNA metabolic process 325 69 0.0000001
GO:0044260 cellular macromolecule metabolic process 6487 729 0.0000001
GO:0010467 gene expression 4325 515 0.0000001
GO:0006396 RNA processing 676 112 0.0000011
GO:0008152 metabolic process 9727 1019 0.0000016
GO:0016070 RNA metabolic process 3695 439 0.0000059
GO:0016032 viral process 674 108 0.0000071
GO:0044764 multi-organism cellular process 682 109 0.0000071
GO:0022613 ribonucleoprotein complex biogenesis 280 57 0.0000074
GO:0016071 mRNA metabolic process 615 100 0.0000119
GO:0071704 organic substance metabolic process 8973 942 0.0000290
GO:0006413 translational initiation 167 38 0.0000663
GO:0044403 symbiosis, encompassing mutualism through parasitism 727 110 0.0000704
GO:0044419 interspecies interaction between organisms 727 110 0.0000704
GO:0044238 primary metabolic process 8723 915 0.0000802
GO:0022904 respiratory electron transport chain 105 27 0.0000876
GO:0043170 macromolecule metabolic process 7144 766 0.0000928
GO:0022900 electron transport chain 106 27 0.0001027
GO:0044249 cellular biosynthetic process 4759 534 0.0001145
GO:0034645 cellular macromolecule biosynthetic process 3922 450 0.0001420
GO:0045333 cellular respiration 158 34 0.0004083
GO:0034470 ncRNA processing 235 46 0.0004121
GO:0006401 RNA catabolic process 222 44 0.0004163
GO:0009059 macromolecule biosynthetic process 4027 456 0.0013195
GO:0006402 mRNA catabolic process 196 39 0.0014702
GO:0042254 ribosome biogenesis 167 35 0.0014702
GO:0009058 biosynthetic process 4901 542 0.0014772
GO:0006415 translational termination 95 23 0.0028244
GO:0006414 translational elongation 121 27 0.0033055
GO:0032984 macromolecular complex disassembly 205 39 0.0036448
GO:1901576 organic substance biosynthetic process 4832 531 0.0046867
GO:0019080 viral gene expression 168 33 0.0057865
GO:0043241 protein complex disassembly 195 37 0.0057865
GO:0071826 ribonucleoprotein complex subunit organization 141 30 0.0057865
GO:0009167 purine ribonucleoside monophosphate metabolic process 465 72 0.0062247
GO:0043624 cellular protein complex disassembly 174 34 0.0062394
GO:0009126 purine nucleoside monophosphate metabolic process 466 72 0.0063033
GO:0006120 mitochondrial electron transport, NADH to ubiquinone 42 13 0.0068228
GO:0042773 ATP synthesis coupled electron transport 54 15 0.0078989
GO:0042775 mitochondrial ATP synthesis coupled electron transport 54 15 0.0078989
GO:0000956 nuclear-transcribed mRNA catabolic process 184 35 0.0079942
GO:0016482 cytoplasmic transport 825 113 0.0081341
GO:0033013 tetrapyrrole metabolic process 50 15 0.0090619
GO:0046034 ATP metabolic process 441 68 0.0099845
GO:0009161 ribonucleoside monophosphate metabolic process 477 72 0.0120955
GO:0008380 RNA splicing 332 54 0.0130914
GO:0022618 ribonucleoprotein complex assembly 135 28 0.0132305
GO:0044265 cellular macromolecule catabolic process 798 109 0.0133292
GO:0000375 RNA splicing, via transesterification reactions 225 40 0.0139924
GO:0044033 multi-organism metabolic process 178 33 0.0139942
GO:0006119 oxidative phosphorylation 70 17 0.0151552
GO:0018130 heterocycle biosynthetic process 3414 384 0.0153677
GO:0019083 viral transcription 158 30 0.0170463
GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 220 39 0.0172047
GO:0000398 mRNA splicing, via spliceosome 220 39 0.0172047
GO:0006352 DNA-templated transcription, initiation 218 39 0.0172930
GO:0009123 nucleoside monophosphate metabolic process 487 72 0.0180055
GO:0006259 DNA metabolic process 838 112 0.0190408
GO:0033554 cellular response to stress 1339 167 0.0204679
GO:0018205 peptidyl-lysine modification 181 34 0.0223092
GO:0016072 rRNA metabolic process 122 25 0.0227174
GO:0044267 cellular protein metabolic process 3491 390 0.0244453
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay 118 24 0.0271959
GO:0044271 cellular nitrogen compound biosynthetic process 3464 386 0.0273467
GO:0006364 rRNA processing 117 24 0.0279727
GO:0006614 SRP-dependent cotranslational protein targeting to membrane 107 22 0.0332368
GO:0006397 mRNA processing 404 61 0.0337706
GO:0007005 mitochondrion organization 298 47 0.0394424
GO:0019438 aromatic compound biosynthetic process 3412 379 0.0405384
GO:0072594 establishment of protein localization to organelle 456 66 0.0410838
GO:0006613 cotranslational protein targeting to membrane 109 22 0.0418358
GO:0032259 methylation 269 44 0.0418358
GO:0016073 snRNA metabolic process 15 7 0.0439017
GO:0033014 tetrapyrrole biosynthetic process 30 10 0.0439017
GO:0045047 protein targeting to ER 110 22 0.0445709
category term numInCat numDEInCat q.value2
6199 GO:0032501 multicellular organismal process 4965 386 0.0002456
6200 GO:0044707 single-multicellular organism process 4822 373 0.0002456
6201 GO:0006928 cellular component movement 1406 82 0.0002456
6202 GO:2000026 regulation of multicellular organismal development 1141 62 0.0002456
6203 GO:0007155 cell adhesion 916 46 0.0002456
6204 GO:0022610 biological adhesion 920 46 0.0002456
6197 GO:0005975 carbohydrate metabolic process 752 38 0.0035553
6198 GO:0045321 leukocyte activation 561 24 0.0035773
6196 GO:0006954 inflammatory response 475 18 0.0041464
6195 GO:0040011 locomotion 1248 76 0.0046227
6194 GO:0051239 regulation of multicellular organismal process 1820 123 0.0065423
6187 GO:0048856 anatomical structure development 3826 300 0.0101346
6190 GO:0048870 cell motility 949 55 0.0101346
6191 GO:0051674 localization of cell 949 55 0.0101346
6192 GO:0009611 response to wounding 834 46 0.0101346
6193 GO:0016477 cell migration 888 50 0.0101346
6186 GO:0032502 developmental process 4293 343 0.0119428
6189 GO:0046649 lymphocyte activation 480 21 0.0125920
6181 GO:0048731 system development 3249 251 0.0137068
6183 GO:0007166 cell surface receptor signaling pathway 2373 174 0.0137068
6184 GO:0044767 single-organism developmental process 4248 340 0.0137068
6185 GO:0002376 immune system process 1939 135 0.0137068
6178 GO:0007154 cell communication 4561 370 0.0189656
6182 GO:0044723 single-organism carbohydrate metabolic process 589 30 0.0189656
6173 GO:0023052 signaling 4498 365 0.0206517
6174 GO:0044700 single organism signaling 4498 365 0.0206517
6171 GO:0048513 organ development 2335 173 0.0226992
6176 GO:0006955 immune response 1140 71 0.0226992
6188 GO:0042113 B cell activation 169 3 0.0226992
6167 GO:0048869 cellular developmental process 2893 223 0.0247081
6168 GO:0007275 multicellular organismal development 3706 295 0.0247081
6169 GO:0030154 cell differentiation 2703 206 0.0247081
6180 GO:0002694 regulation of leukocyte activation 340 13 0.0247081
6165 GO:0009653 anatomical structure morphogenesis 2006 147 0.0251309
6177 GO:0002252 immune effector process 504 24 0.0251309
6175 GO:0050865 regulation of cell activation 366 15 0.0292322
6162 GO:0050793 regulation of developmental process 1513 105 0.0306150
6164 GO:0001775 cell activation 767 44 0.0306150
6172 GO:0043062 extracellular structure organization 324 13 0.0311120
6170 GO:0030198 extracellular matrix organization 323 13 0.0323696
6161 GO:0051960 regulation of nervous system development 473 24 0.0413049
6179 GO:0006022 aminoglycan metabolic process 153 3 0.0445840
6158 GO:0002682 regulation of immune system process 998 63 0.0454700
6155 GO:0007165 signal transduction 4078 332 0.0487665

9

plot of chunk unnamed-chunk-33

Number of significant over represented GO categories: 173

Number of significant under represented GO categories: 16

Number of DE genes: 1669

category term numInCat numDEInCat q.value
GO:0044260 cellular macromolecule metabolic process 6487 727 0.0000000
GO:0043170 macromolecule metabolic process 7144 776 0.0000000
GO:0010467 gene expression 4325 511 0.0000000
GO:0044237 cellular metabolic process 8655 904 0.0000000
GO:0090304 nucleic acid metabolic process 4168 492 0.0000000
GO:0008152 metabolic process 9727 984 0.0000000
GO:0071704 organic substance metabolic process 8973 922 0.0000000
GO:0016070 RNA metabolic process 3695 440 0.0000000
GO:0044238 primary metabolic process 8723 899 0.0000000
GO:0044267 cellular protein metabolic process 3491 417 0.0000000
GO:0034645 cellular macromolecule biosynthetic process 3922 453 0.0000000
GO:0009059 macromolecule biosynthetic process 4027 462 0.0000001
GO:0044249 cellular biosynthetic process 4759 528 0.0000002
GO:0016071 mRNA metabolic process 615 101 0.0000003
GO:0006412 translation 496 85 0.0000004
GO:0006139 nucleobase-containing compound metabolic process 5434 590 0.0000004
GO:0070647 protein modification by small protein conjugation or removal 731 116 0.0000005
GO:1901576 organic substance biosynthetic process 4832 531 0.0000005
GO:0034641 cellular nitrogen compound metabolic process 5753 617 0.0000007
GO:0046483 heterocycle metabolic process 5564 599 0.0000009
GO:0009058 biosynthetic process 4901 534 0.0000015
GO:0019538 protein metabolic process 4124 461 0.0000017
GO:0006725 cellular aromatic compound metabolic process 5569 597 0.0000017
GO:1901360 organic cyclic compound metabolic process 5728 607 0.0000070
GO:0045333 cellular respiration 158 36 0.0000085
GO:0006807 nitrogen compound metabolic process 6074 638 0.0000085
GO:0032774 RNA biosynthetic process 3065 354 0.0000085
GO:0044265 cellular macromolecule catabolic process 798 117 0.0000114
GO:0032446 protein modification by small protein conjugation 654 101 0.0000133
GO:0018130 heterocycle biosynthetic process 3414 385 0.0000176
GO:0009057 macromolecule catabolic process 983 137 0.0000178
GO:0006366 transcription from RNA polymerase II promoter 1448 188 0.0000187
GO:0006413 translational initiation 167 37 0.0000192
GO:0044271 cellular nitrogen compound biosynthetic process 3464 389 0.0000197
GO:0034654 nucleobase-containing compound biosynthetic process 3351 378 0.0000216
GO:0016567 protein ubiquitination 612 95 0.0000218
GO:2000112 regulation of cellular macromolecule biosynthetic process 3131 358 0.0000218
GO:0019438 aromatic compound biosynthetic process 3412 383 0.0000258
GO:0010556 regulation of macromolecule biosynthetic process 3216 365 0.0000278
GO:1901362 organic cyclic compound biosynthetic process 3505 391 0.0000310
GO:0060255 regulation of macromolecule metabolic process 4403 477 0.0000402
GO:0051254 positive regulation of RNA metabolic process 1050 143 0.0000404
GO:0031326 regulation of cellular biosynthetic process 3343 375 0.0000534
GO:1902680 positive regulation of RNA biosynthetic process 1030 140 0.0000561
GO:0010557 positive regulation of macromolecule biosynthetic process 1169 154 0.0000695
GO:0009889 regulation of biosynthetic process 3370 376 0.0000796
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 1183 155 0.0000998
GO:0010468 regulation of gene expression 3468 385 0.0001747
GO:0006357 regulation of transcription from RNA polymerase II promoter 1306 168 0.0002241
GO:0006325 chromatin organization 563 86 0.0002574
GO:0045893 positive regulation of transcription, DNA-templated 989 133 0.0003022
GO:0006401 RNA catabolic process 222 42 0.0003083
GO:0010604 positive regulation of macromolecule metabolic process 1913 229 0.0003567
GO:0009891 positive regulation of biosynthetic process 1263 161 0.0004321
GO:0031328 positive regulation of cellular biosynthetic process 1244 159 0.0004548
GO:0006402 mRNA catabolic process 196 38 0.0004818
GO:0006396 RNA processing 676 96 0.0004818
GO:0010628 positive regulation of gene expression 1080 142 0.0004818
GO:0051173 positive regulation of nitrogen compound metabolic process 1207 155 0.0004937
GO:0043412 macromolecule modification 2854 324 0.0005514
GO:0006351 transcription, DNA-templated 2954 332 0.0005597
GO:0000956 nuclear-transcribed mRNA catabolic process 184 36 0.0005847
GO:0051252 regulation of RNA metabolic process 2968 333 0.0007221
GO:0000209 protein polyubiquitination 187 37 0.0007683
GO:0006464 cellular protein modification process 2739 312 0.0008065
GO:0036211 protein modification process 2739 312 0.0008065
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay 118 26 0.0009698
GO:0022613 ribonucleoprotein complex biogenesis 280 48 0.0009887
GO:0042180 cellular ketone metabolic process 210 39 0.0012286
GO:0006415 translational termination 95 22 0.0012928
GO:0018205 peptidyl-lysine modification 181 36 0.0013308
GO:0022904 respiratory electron transport chain 105 23 0.0014761
GO:0022900 electron transport chain 106 23 0.0017605
GO:2001141 regulation of RNA biosynthetic process 2890 322 0.0019297
GO:0010565 regulation of cellular ketone metabolic process 161 32 0.0019779
GO:0006091 generation of precursor metabolites and energy 395 60 0.0024763
GO:0055114 oxidation-reduction process 895 115 0.0025908
GO:0016573 histone acetylation 130 28 0.0027554
GO:0006355 regulation of transcription, DNA-templated 2853 317 0.0030642
GO:0006475 internal protein amino acid acetylation 138 29 0.0030693
GO:0051253 negative regulation of RNA metabolic process 853 113 0.0032679
GO:0016568 chromatin modification 502 75 0.0032965
GO:0018393 internal peptidyl-lysine acetylation 133 28 0.0040340
GO:0006886 intracellular protein transport 758 101 0.0043270
GO:0016482 cytoplasmic transport 825 108 0.0045833
GO:0015980 energy derivation by oxidation of organic compounds 319 50 0.0046501
GO:0031365 N-terminal protein amino acid modification 20 9 0.0047240
GO:0006473 protein acetylation 150 30 0.0048593
GO:0030163 protein catabolic process 596 84 0.0051623
GO:0000077 DNA damage checkpoint 148 29 0.0053041
GO:0000075 cell cycle checkpoint 240 41 0.0054455
GO:0033365 protein localization to organelle 603 83 0.0054455
GO:0016032 viral process 674 90 0.0065971
GO:0009893 positive regulation of metabolic process 2103 239 0.0065971
GO:0018394 peptidyl-lysine acetylation 138 28 0.0066602
GO:2000113 negative regulation of cellular macromolecule biosynthetic process 914 118 0.0066984
GO:0031571 mitotic G1 DNA damage checkpoint 75 18 0.0076746
GO:0044819 mitotic G1/S transition checkpoint 76 18 0.0091440
GO:0044783 G1 DNA damage checkpoint 76 18 0.0093198
GO:0051171 regulation of nitrogen compound metabolic process 3755 400 0.0095857
category term numInCat numDEInCat q.value2
5918 GO:0042060 wound healing 596 24 0.0131418
5914 GO:0007155 cell adhesion 916 50 0.0287623
5915 GO:0022610 biological adhesion 920 50 0.0287623
5916 GO:0007596 blood coagulation 479 19 0.0287623
5917 GO:0050817 coagulation 482 19 0.0287623
5913 GO:0009611 response to wounding 834 43 0.0294867
5911 GO:0001775 cell activation 767 38 0.0297453
5912 GO:0007599 hemostasis 484 20 0.0297453
5906 GO:0040011 locomotion 1248 76 0.0349597
5907 GO:0002252 immune effector process 504 21 0.0349597
5908 GO:0050776 regulation of immune response 667 32 0.0349597
5909 GO:0030198 extracellular matrix organization 323 11 0.0349597
5910 GO:0043062 extracellular structure organization 324 11 0.0349597
5905 GO:0009605 response to external stimulus 1592 101 0.0358815
5904 GO:0006928 cellular component movement 1406 89 0.0364845
5903 GO:0002684 positive regulation of immune system process 611 29 0.0473784

10

plot of chunk unnamed-chunk-37

Number of significant over represented GO categories: 211

Number of significant under represented GO categories: 0

Number of DE genes: 1668

category term numInCat numDEInCat q.value
GO:0003012 muscle system process 299 105 0.0000000
GO:0006936 muscle contraction 253 92 0.0000000
GO:0061061 muscle structure development 471 129 0.0000000
GO:0007517 muscle organ development 311 97 0.0000000
GO:0006941 striated muscle contraction 105 49 0.0000000
GO:0030049 muscle filament sliding 39 28 0.0000000
GO:0033275 actin-myosin filament sliding 39 28 0.0000000
GO:0060537 muscle tissue development 303 78 0.0000000
GO:0014706 striated muscle tissue development 292 76 0.0000000
GO:0070252 actin-mediated cell contraction 55 32 0.0000000
GO:0042692 muscle cell differentiation 280 73 0.0000000
GO:0060538 skeletal muscle organ development 160 51 0.0000000
GO:0007519 skeletal muscle tissue development 155 50 0.0000000
GO:0030048 actin filament-based movement 70 34 0.0000000
GO:0051146 striated muscle cell differentiation 203 57 0.0000000
GO:0003008 system process 1112 168 0.0000000
GO:0098655 cation transmembrane transport 467 91 0.0000000
GO:0055001 muscle cell development 137 44 0.0000000
GO:0055002 striated muscle cell development 128 42 0.0000000
GO:0006091 generation of precursor metabolites and energy 395 78 0.0000000
GO:0034220 ion transmembrane transport 657 109 0.0000000
GO:0003009 skeletal muscle contraction 27 17 0.0000000
GO:0015980 energy derivation by oxidation of organic compounds 319 65 0.0000000
GO:0050879 multicellular organismal movement 36 19 0.0000000
GO:0050881 musculoskeletal movement 36 19 0.0000000
GO:0098662 inorganic cation transmembrane transport 397 75 0.0000000
GO:0014902 myotube differentiation 89 30 0.0000000
GO:0060047 heart contraction 145 40 0.0000000
GO:0098660 inorganic ion transmembrane transport 456 81 0.0000000
GO:0006812 cation transport 768 117 0.0000000
GO:0003015 heart process 146 40 0.0000000
GO:0006006 glucose metabolic process 203 46 0.0000001
GO:0090257 regulation of muscle system process 157 40 0.0000002
GO:0006811 ion transport 1118 150 0.0000002
GO:0051147 regulation of muscle cell differentiation 110 31 0.0000003
GO:0034765 regulation of ion transmembrane transport 249 51 0.0000004
GO:0006112 energy reserve metabolic process 158 38 0.0000006
GO:0044707 single-multicellular organism process 4822 491 0.0000013
GO:0034762 regulation of transmembrane transport 259 51 0.0000015
GO:0019318 hexose metabolic process 235 47 0.0000019
GO:0044057 regulation of system process 312 58 0.0000020
GO:0032501 multicellular organismal process 4965 501 0.0000027
GO:0048513 organ development 2335 265 0.0000027
GO:0048747 muscle fiber development 71 24 0.0000034
GO:0030239 myofibril assembly 44 19 0.0000034
GO:0060048 cardiac muscle contraction 72 24 0.0000040
GO:0030001 metal ion transport 584 88 0.0000040
GO:0055085 transmembrane transport 990 131 0.0000040
GO:0043269 regulation of ion transport 403 67 0.0000050
GO:0006942 regulation of striated muscle contraction 74 23 0.0000050
GO:0048644 muscle organ morphogenesis 58 21 0.0000074
GO:0014888 striated muscle adaptation 30 14 0.0000079
GO:0032412 regulation of ion transmembrane transporter activity 118 30 0.0000082
GO:0070588 calcium ion transmembrane transport 140 33 0.0000125
GO:0070296 sarcoplasmic reticulum calcium ion transport 30 14 0.0000128
GO:0022898 regulation of transmembrane transporter activity 121 30 0.0000139
GO:0005996 monosaccharide metabolic process 253 47 0.0000140
GO:0008016 regulation of heart contraction 130 31 0.0000146
GO:0015672 monovalent inorganic cation transport 351 59 0.0000146
GO:0051153 regulation of striated muscle cell differentiation 73 22 0.0000149
GO:0006937 regulation of muscle contraction 124 30 0.0000152
GO:0031032 actomyosin structure organization 60 21 0.0000166
GO:0009888 tissue development 1347 165 0.0000186
GO:1901019 regulation of calcium ion transmembrane transporter activity 46 17 0.0000208
GO:1903169 regulation of calcium ion transmembrane transport 46 17 0.0000208
GO:0010830 regulation of myotube differentiation 52 18 0.0000212
GO:0016051 carbohydrate biosynthetic process 180 37 0.0000296
GO:0010959 regulation of metal ion transport 216 42 0.0000340
GO:0005977 glycogen metabolic process 78 22 0.0000361
GO:0044699 single-organism process 10473 940 0.0000384
GO:0006073 cellular glucan metabolic process 79 22 0.0000450
GO:0044042 glucan metabolic process 79 22 0.0000450
GO:0030029 actin filament-based process 507 77 0.0000467
GO:0048741 skeletal muscle fiber development 50 17 0.0000513
GO:0032409 regulation of transporter activity 130 30 0.0000581
GO:0014904 myotube cell development 52 17 0.0000942
GO:0055114 oxidation-reduction process 895 114 0.0001259
GO:0060415 muscle tissue morphogenesis 52 18 0.0001311
GO:0002027 regulation of heart rate 65 19 0.0001507
GO:0043501 skeletal muscle adaptation 16 9 0.0002364
GO:0005978 glycogen biosynthetic process 50 16 0.0002364
GO:0009250 glucan biosynthetic process 50 16 0.0002364
GO:2001257 regulation of cation channel activity 55 17 0.0002877
GO:0006816 calcium ion transport 276 47 0.0002952
GO:0060314 regulation of ryanodine-sensitive calcium-release channel activity 25 11 0.0003501
GO:0043500 muscle adaptation 57 17 0.0003665
GO:0044262 cellular carbohydrate metabolic process 249 43 0.0004009
GO:0071804 cellular potassium ion transport 104 24 0.0004758
GO:0071805 potassium ion transmembrane transport 104 24 0.0004758
GO:0070838 divalent metal ion transport 292 48 0.0006218
GO:0072511 divalent inorganic cation transport 294 48 0.0007403
GO:0048634 regulation of muscle organ development 100 23 0.0008522
GO:0055013 cardiac muscle cell development 47 16 0.0008947
GO:0042391 regulation of membrane potential 295 48 0.0009230
GO:0014808 release of sequestered calcium ion into cytosol by sarcoplasmic reticulum 27 11 0.0011003
GO:0007528 neuromuscular junction development 38 13 0.0011379
GO:0005976 polysaccharide metabolic process 111 24 0.0013134
GO:0055006 cardiac cell development 49 16 0.0014426
GO:0006094 gluconeogenesis 71 18 0.0015102
GO:0048856 anatomical structure development 3826 383 0.0017265
category term numInCat numDEInCat q.value2
6012 GO:0007155 cell adhesion 916 51 0.70229