opts_chunk$set(fig.path = “ rep1 ”)

  title: "goseq results"
  author: "Andy Beck"
  date: "Tuesday, May 05, 2015"
  output: html_document
  style: flat-table.css

This is an initial analysis of GO term enrichment for DE results from all traits that we analyzed.

For this report, the cutoff for differential expression is FDR \(\leq\) 0.1. We display at minimum 5 categories for each trait, and at most 20, ordered by significance.

This report was last generated on Tue May 12 10:31:01 PM 2015

age/peer_k00_age_biopsy_all_genes.txt

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Number of significant GO categories: 103

Number of DE genes: 6022

category term numInCat numDEInCat q.value
GO:0090304 nucleic acid metabolic process 4166 1631 0
GO:0016070 RNA metabolic process 3693 1442 0
GO:0010467 gene expression 4322 1632 0
GO:0006397 mRNA processing 404 223 0
GO:0006351 transcription, DNA-templated 2952 1169 0
GO:0008380 RNA splicing 332 188 0
GO:0010468 regulation of gene expression 3465 1339 0
GO:0051252 regulation of RNA metabolic process 2966 1166 0
GO:0006396 RNA processing 676 327 0
GO:0032774 RNA biosynthetic process 3063 1184 0
GO:2001141 regulation of RNA biosynthetic process 2888 1125 0
GO:0010556 regulation of macromolecule biosynthetic process 3214 1236 0
GO:0006139 nucleobase-containing compound metabolic process 5435 1972 0
GO:0006355 regulation of transcription, DNA-templated 2851 1111 0
GO:2000112 regulation of cellular macromolecule biosynthetic process 3129 1205 0
GO:0000375 RNA splicing, via transesterification reactions 225 133 0
GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 220 130 0
GO:0000398 mRNA splicing, via spliceosome 220 130 0
GO:0046483 heterocycle metabolic process 5565 2005 0
GO:0031326 regulation of cellular biosynthetic process 3340 1269 0

sex/peer_k00_sex_all_genes.txt

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Number of significant GO categories: 65

Number of DE genes: 1.4723 × 104

category term numInCat numDEInCat q.value
GO:0016070 RNA metabolic process 3693 2808 0.0000443
GO:0009058 biosynthetic process 4899 3691 0.0000443
GO:1901576 organic substance biosynthetic process 4830 3636 0.0000699
GO:0090304 nucleic acid metabolic process 4166 3148 0.0000699
GO:0034645 cellular macromolecule biosynthetic process 3920 2968 0.0000699
GO:0044249 cellular biosynthetic process 4756 3578 0.0000924
GO:1901360 organic cyclic compound metabolic process 5728 4288 0.0001007
GO:0009059 macromolecule biosynthetic process 4025 3040 0.0001207
GO:0034654 nucleobase-containing compound biosynthetic process 3350 2541 0.0001741
GO:0018130 heterocycle biosynthetic process 3413 2587 0.0001741
GO:0006725 cellular aromatic compound metabolic process 5569 4167 0.0001741
GO:0044271 cellular nitrogen compound biosynthetic process 3463 2622 0.0002089
GO:0019438 aromatic compound biosynthetic process 3410 2582 0.0004580
GO:0006807 nitrogen compound metabolic process 6075 4534 0.0006536
GO:1901362 organic cyclic compound biosynthetic process 3503 2649 0.0006753
GO:0006351 transcription, DNA-templated 2952 2245 0.0007337
GO:0044260 cellular macromolecule metabolic process 6484 4830 0.0007724
GO:0034637 cellular carbohydrate biosynthetic process 75 71 0.0007724
GO:0046483 heterocycle metabolic process 5565 4160 0.0007724
GO:0034641 cellular nitrogen compound metabolic process 5755 4298 0.0007826

smoking/peer_k01_smoking_all_genes.txt

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Number of significant GO categories: 0

Number of DE genes: 430

category term numInCat numDEInCat q.value
GO:0015980 energy derivation by oxidation of organic compounds 319 21 0.2022297
GO:0045333 cellular respiration 158 13 0.2022297
GO:0006091 generation of precursor metabolites and energy 394 23 0.2793190
GO:0007379 segment specification 15 4 0.7268145
GO:0006532 aspartate biosynthetic process 2 2 0.7268145

traits/peer_k00_DBP_all_genes.txt

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Number of significant GO categories: 0

Number of DE genes: 0

category term numInCat numDEInCat q.value
GO:0000002 mitochondrial genome maintenance 20 0 1
GO:0000003 reproduction 687 0 1
GO:0000012 single strand break repair 6 0 1
GO:0000018 regulation of DNA recombination 46 0 1
GO:0000019 regulation of mitotic recombination 4 0 1

traits/peer_k00_fS_Kol_all_genes.txt

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Number of significant GO categories: 0

Number of DE genes: 33

category term numInCat numDEInCat q.value
GO:0006531 aspartate metabolic process 7 2 0.2741824
GO:0000053 argininosuccinate metabolic process 1 1 1.0000000
GO:0051028 mRNA transport 124 3 1.0000000
GO:0009066 aspartate family amino acid metabolic process 39 2 1.0000000
GO:0050657 nucleic acid transport 144 3 1.0000000

traits/peer_k00_fS_Kol_LDL_c_all_genes.txt

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Number of significant GO categories: 0

Number of DE genes: 36

category term numInCat numDEInCat q.value
GO:0006531 aspartate metabolic process 7 2 0.3331899
GO:0044539 long-chain fatty acid import 6 2 0.3331899
GO:0034201 response to oleic acid 6 2 0.3331899
GO:0055098 response to low-density lipoprotein particle 6 2 0.3623210
GO:0051028 mRNA transport 124 4 0.3623210

traits/peer_k00_fS_Krea_all_genes.txt

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Number of significant GO categories: 0

Number of DE genes: 0

category term numInCat numDEInCat q.value
GO:0000002 mitochondrial genome maintenance 20 0 1
GO:0000003 reproduction 687 0 1
GO:0000012 single strand break repair 6 0 1
GO:0000018 regulation of DNA recombination 46 0 1
GO:0000019 regulation of mitotic recombination 4 0 1

traits/peer_k00_GL30_all_genes.txt

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Number of significant GO categories: 81

Number of DE genes: 930

category term numInCat numDEInCat q.value
GO:0045333 cellular respiration 158 42 0.00e+00
GO:0022904 respiratory electron transport chain 105 33 0.00e+00
GO:0022900 electron transport chain 106 33 0.00e+00
GO:0015980 energy derivation by oxidation of organic compounds 319 56 0.00e+00
GO:0006091 generation of precursor metabolites and energy 394 63 0.00e+00
GO:0055114 oxidation-reduction process 896 98 0.00e+00
GO:1902600 hydrogen ion transmembrane transport 84 24 0.00e+00
GO:0006119 oxidative phosphorylation 70 20 1.00e-07
GO:0044281 small molecule metabolic process 2955 224 3.00e-07
GO:0042773 ATP synthesis coupled electron transport 54 17 3.00e-07
GO:0042775 mitochondrial ATP synthesis coupled electron transport 54 17 3.00e-07
GO:0015992 proton transport 112 24 9.00e-07
GO:0006818 hydrogen transport 114 24 1.20e-06
GO:0015985 energy coupled proton transport, down electrochemical gradient 19 10 3.20e-06
GO:0015986 ATP synthesis coupled proton transport 19 10 3.20e-06
GO:0006120 mitochondrial electron transport, NADH to ubiquinone 42 14 3.20e-06
GO:0006164 purine nucleotide biosynthetic process 191 30 3.07e-05
GO:0009145 purine nucleoside triphosphate biosynthetic process 47 14 3.08e-05
GO:0009152 purine ribonucleotide biosynthetic process 185 29 4.75e-05
GO:0009260 ribonucleotide biosynthetic process 198 30 6.20e-05

traits/peer_k00_ratio_apob_apoa1_all_genes.txt

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Number of significant GO categories: 161

Number of DE genes: 567

category term numInCat numDEInCat q.value
GO:0045321 leukocyte activation 561 61 0.0e+00
GO:0046649 lymphocyte activation 480 55 0.0e+00
GO:0001775 cell activation 767 69 0.0e+00
GO:0042110 T cell activation 347 42 0.0e+00
GO:0002376 immune system process 1936 117 0.0e+00
GO:0006955 immune response 1137 81 0.0e+00
GO:0002682 regulation of immune system process 997 74 0.0e+00
GO:0002694 regulation of leukocyte activation 340 36 1.0e-07
GO:0051249 regulation of lymphocyte activation 298 33 1.0e-07
GO:0050865 regulation of cell activation 366 37 1.0e-07
GO:0050776 regulation of immune response 666 52 2.0e-07
GO:0050896 response to stimulus 6126 249 2.0e-07
GO:0030098 lymphocyte differentiation 235 28 5.0e-07
GO:0023052 signaling 4496 196 5.0e-07
GO:0044700 single organism signaling 4496 196 5.0e-07
GO:0002684 positive regulation of immune system process 610 48 5.0e-07
GO:0006952 defense response 1178 73 6.0e-07
GO:0007166 cell surface receptor signaling pathway 2374 120 1.2e-06
GO:0007165 signal transduction 4077 180 1.2e-06
GO:0007154 cell communication 4559 196 1.2e-06

traits/peer_k00_S_Ca_30_all_genes.txt

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Number of significant GO categories: 0

Number of DE genes: 0

category term numInCat numDEInCat q.value
GO:0000002 mitochondrial genome maintenance 20 0 1
GO:0000003 reproduction 687 0 1
GO:0000012 single strand break repair 6 0 1
GO:0000018 regulation of DNA recombination 46 0 1
GO:0000019 regulation of mitotic recombination 4 0 1

traits/peer_k00_total_daily_physical_activity_all_genes.txt

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Number of significant GO categories: 0

Number of DE genes: 4

category term numInCat numDEInCat q.value
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity 189 2 1
GO:0060753 regulation of mast cell chemotaxis 4 1 1
GO:0060754 positive regulation of mast cell chemotaxis 4 1 1
GO:0030335 positive regulation of cell migration 260 2 1
GO:2000147 positive regulation of cell motility 265 2 1

traits/peer_k01_fS_Trigly_all_genes.txt

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Number of significant GO categories: 239

Number of DE genes: 3115

category term numInCat numDEInCat q.value
GO:0001775 cell activation 767 212 0.0e+00
GO:0045321 leukocyte activation 561 166 0.0e+00
GO:0046649 lymphocyte activation 480 142 0.0e+00
GO:0006413 translational initiation 167 65 0.0e+00
GO:0006415 translational termination 95 44 0.0e+00
GO:0006614 SRP-dependent cotranslational protein targeting to membrane 107 47 0.0e+00
GO:0055114 oxidation-reduction process 896 225 0.0e+00
GO:0006414 translational elongation 121 51 0.0e+00
GO:0072599 establishment of protein localization to endoplasmic reticulum 111 48 0.0e+00
GO:0006955 immune response 1137 272 0.0e+00
GO:0006412 translation 496 140 0.0e+00
GO:0002376 immune system process 1936 427 0.0e+00
GO:0006613 cotranslational protein targeting to membrane 109 47 0.0e+00
GO:0042110 T cell activation 347 107 0.0e+00
GO:0045047 protein targeting to ER 110 47 0.0e+00
GO:0002682 regulation of immune system process 997 243 0.0e+00
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay 118 48 2.0e-07
GO:0070972 protein localization to endoplasmic reticulum 128 50 4.0e-07
GO:0050776 regulation of immune response 666 167 5.3e-06
GO:0002764 immune response-regulating signaling pathway 428 118 5.3e-06

traits/peer_k01_GL120_all_genes.txt

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Number of significant GO categories: 2

Number of DE genes: 1642

category term numInCat numDEInCat q.value
GO:0044267 cellular protein metabolic process 3491 402 0.0002147
GO:0019538 protein metabolic process 4128 448 0.0343544
GO:0032268 regulation of cellular protein metabolic process 1414 174 0.0693627
GO:0016310 phosphorylation 1655 200 0.0693627
GO:0006464 cellular protein modification process 2739 310 0.0788007

traits/peer_k01_GL60_all_genes.txt

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Number of significant GO categories: 16

Number of DE genes: 1585

category term numInCat numDEInCat q.value
GO:0045333 cellular respiration 158 46 0.0000000
GO:0022904 respiratory electron transport chain 105 34 0.0000000
GO:0022900 electron transport chain 106 34 0.0000000
GO:0015980 energy derivation by oxidation of organic compounds 319 64 0.0000001
GO:0006091 generation of precursor metabolites and energy 394 73 0.0000003
GO:0055114 oxidation-reduction process 896 129 0.0000028
GO:1902600 hydrogen ion transmembrane transport 84 21 0.0032164
GO:0042773 ATP synthesis coupled electron transport 54 16 0.0032164
GO:0042775 mitochondrial ATP synthesis coupled electron transport 54 16 0.0032164
GO:0042776 mitochondrial ATP synthesis coupled proton transport 14 8 0.0042008
GO:0015985 energy coupled proton transport, down electrochemical gradient 19 9 0.0049283
GO:0015986 ATP synthesis coupled proton transport 19 9 0.0049283
GO:0006119 oxidative phosphorylation 70 18 0.0059398
GO:0006120 mitochondrial electron transport, NADH to ubiquinone 42 13 0.0094368
GO:0046390 ribose phosphate biosynthetic process 201 35 0.0367030
GO:0044281 small molecule metabolic process 2955 316 0.0373474

traits/peer_k01_S_ALAT_all_genes.txt

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Number of significant GO categories: 0

Number of DE genes: 615

category term numInCat numDEInCat q.value
GO:0032370 positive regulation of lipid transport 34 7 1
GO:0006883 cellular sodium ion homeostasis 11 4 1
GO:0030206 chondroitin sulfate biosynthetic process 23 5 1
GO:0050651 dermatan sulfate proteoglycan biosynthetic process 14 4 1
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity 80 9 1

traits/peer_k01_S_hs_CRP_all_genes.txt

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Number of significant GO categories: 35

Number of DE genes: 942

category term numInCat numDEInCat q.value
GO:0023052 signaling 4496 295 0.0011997
GO:0044700 single organism signaling 4496 295 0.0011997
GO:0007154 cell communication 4559 296 0.0019709
GO:0001525 angiogenesis 350 40 0.0066845
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway 646 62 0.0071509
GO:0048514 blood vessel morphogenesis 421 45 0.0071509
GO:0007165 signal transduction 4077 266 0.0071509
GO:0001568 blood vessel development 480 49 0.0073610
GO:0001944 vasculature development 509 51 0.0073610
GO:0043085 positive regulation of catalytic activity 1225 98 0.0166089
GO:0019752 carboxylic acid metabolic process 829 70 0.0218441
GO:0032501 multicellular organismal process 4965 310 0.0218441
GO:0072358 cardiovascular system development 771 68 0.0218441
GO:0072359 circulatory system development 771 68 0.0218441
GO:0044707 single-multicellular organism process 4822 302 0.0218441
GO:0035556 intracellular signal transduction 1995 143 0.0218441
GO:0044093 positive regulation of molecular function 1425 109 0.0218441
GO:0007167 enzyme linked receptor protein signaling pathway 890 75 0.0227087
GO:0050896 response to stimulus 6126 369 0.0254538
GO:1901700 response to oxygen-containing compound 1037 82 0.0257553

traits/peer_k01_strenuous_physical_activity_all_genes.txt

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Number of significant GO categories: 0

Number of DE genes: 2949

category term numInCat numDEInCat q.value
GO:0009068 aspartate family amino acid catabolic process 15 10 0.1820805
GO:0042776 mitochondrial ATP synthesis coupled proton transport 14 9 0.1820805
GO:0009066 aspartate family amino acid metabolic process 39 17 0.1820805
GO:0015985 energy coupled proton transport, down electrochemical gradient 19 10 0.2833581
GO:0015986 ATP synthesis coupled proton transport 19 10 0.2833581

traits/peer_k01_S_Uraat_all_genes.txt

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Number of significant GO categories: 1

Number of DE genes: 1191

category term numInCat numDEInCat q.value
GO:0055114 oxidation-reduction process 896 95 0.0025284
GO:0002690 positive regulation of leukocyte chemotaxis 50 12 0.1661247
GO:0030595 leukocyte chemotaxis 130 21 0.1661247
GO:0002687 positive regulation of leukocyte migration 70 14 0.1740304
GO:0002688 regulation of leukocyte chemotaxis 62 13 0.1740304

traits/peer_k01_WHR_all_genes.txt

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Number of significant GO categories: 1

Number of DE genes: 2123

category term numInCat numDEInCat q.value
GO:0055114 oxidation-reduction process 896 145 0.0327616
GO:0006091 generation of precursor metabolites and energy 394 70 0.1444488
GO:0022904 respiratory electron transport chain 105 25 0.1444488
GO:0015980 energy derivation by oxidation of organic compounds 319 59 0.1444488
GO:0022900 electron transport chain 106 25 0.1444488

traits/peer_k03_bmi_all_genes.txt

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Number of significant GO categories: 62

Number of DE genes: 6685

category term numInCat numDEInCat q.value
GO:0006414 translational elongation 121 100 0
GO:0006415 translational termination 95 83 0
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay 118 97 0
GO:0006413 translational initiation 167 121 0
GO:0006614 SRP-dependent cotranslational protein targeting to membrane 107 86 0
GO:0006613 cotranslational protein targeting to membrane 109 87 0
GO:0072599 establishment of protein localization to endoplasmic reticulum 111 88 0
GO:0045047 protein targeting to ER 110 87 0
GO:0070972 protein localization to endoplasmic reticulum 128 96 0
GO:0006612 protein targeting to membrane 171 116 0
GO:0000956 nuclear-transcribed mRNA catabolic process 184 121 0
GO:0006412 translation 496 260 0
GO:0019083 viral transcription 158 105 0
GO:0043624 cellular protein complex disassembly 174 113 0
GO:0043241 protein complex disassembly 195 122 0
GO:0019080 viral gene expression 168 108 0
GO:0006402 mRNA catabolic process 196 122 0
GO:0044033 multi-organism metabolic process 178 110 0
GO:0090150 establishment of protein localization to membrane 296 165 0
GO:0032984 macromolecular complex disassembly 205 123 0

traits/peer_k03_fS_C_pept_30_all_genes.txt

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Number of significant GO categories: 56

Number of DE genes: 6803

category term numInCat numDEInCat q.value
GO:0006414 translational elongation 121 85 0.00e+00
GO:0006415 translational termination 95 70 0.00e+00
GO:0006413 translational initiation 167 105 0.00e+00
GO:0006614 SRP-dependent cotranslational protein targeting to membrane 107 74 0.00e+00
GO:0006613 cotranslational protein targeting to membrane 109 75 0.00e+00
GO:0045047 protein targeting to ER 110 75 0.00e+00
GO:0072599 establishment of protein localization to endoplasmic reticulum 111 75 0.00e+00
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay 118 78 0.00e+00
GO:0070972 protein localization to endoplasmic reticulum 128 82 0.00e+00
GO:0043624 cellular protein complex disassembly 174 103 1.00e-07
GO:0006612 protein targeting to membrane 171 100 3.00e-07
GO:0043241 protein complex disassembly 195 111 4.00e-07
GO:0019083 viral transcription 158 92 1.30e-06
GO:0032984 macromolecular complex disassembly 205 113 2.00e-06
GO:0002757 immune response-activating signal transduction 333 170 4.20e-06
GO:0019080 viral gene expression 168 95 4.90e-06
GO:0006412 translation 496 233 1.17e-05
GO:0044033 multi-organism metabolic process 178 98 1.73e-05
GO:0002253 activation of immune response 373 181 8.47e-05
GO:0050778 positive regulation of immune response 441 208 9.84e-05

traits/peer_k03_fS_C_pept_all_genes.txt

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Number of significant GO categories: 120

Number of DE genes: 7500

category term numInCat numDEInCat q.value
GO:0006413 translational initiation 167 120 0e+00
GO:0006415 translational termination 95 78 0e+00
GO:0006414 translational elongation 121 93 0e+00
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay 118 91 0e+00
GO:0006614 SRP-dependent cotranslational protein targeting to membrane 107 84 0e+00
GO:0006613 cotranslational protein targeting to membrane 109 85 0e+00
GO:0045047 protein targeting to ER 110 85 0e+00
GO:0072599 establishment of protein localization to endoplasmic reticulum 111 85 0e+00
GO:0070972 protein localization to endoplasmic reticulum 128 94 0e+00
GO:0000956 nuclear-transcribed mRNA catabolic process 184 121 0e+00
GO:0006402 mRNA catabolic process 196 126 0e+00
GO:0019083 viral transcription 158 105 0e+00
GO:0006401 RNA catabolic process 222 138 0e+00
GO:0006955 immune response 1137 551 0e+00
GO:0006612 protein targeting to membrane 171 111 0e+00
GO:0019080 viral gene expression 168 107 0e+00
GO:0044033 multi-organism metabolic process 178 112 0e+00
GO:0043241 protein complex disassembly 195 119 0e+00
GO:0043933 macromolecular complex subunit organization 1450 673 1e-07
GO:0043624 cellular protein complex disassembly 174 108 1e-07

traits/peer_k03_fS_Kol_HDL_all_genes.txt

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Number of significant GO categories: 74

Number of DE genes: 3344

category term numInCat numDEInCat q.value
GO:0006613 cotranslational protein targeting to membrane 109 58 0.0e+00
GO:0045047 protein targeting to ER 110 58 0.0e+00
GO:0006614 SRP-dependent cotranslational protein targeting to membrane 107 57 0.0e+00
GO:0072599 establishment of protein localization to endoplasmic reticulum 111 58 0.0e+00
GO:0006414 translational elongation 121 61 0.0e+00
GO:0070972 protein localization to endoplasmic reticulum 128 63 0.0e+00
GO:0006415 translational termination 95 51 0.0e+00
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay 118 58 0.0e+00
GO:0006612 protein targeting to membrane 171 72 0.0e+00
GO:0006413 translational initiation 167 68 0.0e+00
GO:0090150 establishment of protein localization to membrane 296 101 0.0e+00
GO:0019083 viral transcription 158 62 0.0e+00
GO:0072657 protein localization to membrane 371 117 0.0e+00
GO:0019080 viral gene expression 168 63 2.0e-07
GO:0044033 multi-organism metabolic process 178 65 4.0e-07
GO:0043624 cellular protein complex disassembly 174 64 7.0e-07
GO:0042110 T cell activation 347 107 7.0e-07
GO:0043241 protein complex disassembly 195 69 1.2e-06
GO:0000956 nuclear-transcribed mRNA catabolic process 184 66 1.3e-06
GO:1902578 single-organism localization 426 124 1.5e-06

traits/peer_k03_GL0_all_genes.txt

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Number of significant GO categories: 1

Number of DE genes: 255

category term numInCat numDEInCat q.value
GO:0055091 phospholipid homeostasis 7 4 0.0193404
GO:0055081 anion homeostasis 27 5 0.2910831
GO:0019395 fatty acid oxidation 77 7 0.6614516
GO:0034440 lipid oxidation 79 7 0.6614516
GO:0070972 protein localization to endoplasmic reticulum 128 8 0.7992201

traits/peer_k03_S_Ca_all_genes.txt

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Number of significant GO categories: 0

Number of DE genes: 13

category term numInCat numDEInCat q.value
GO:0071478 cellular response to radiation 116 3 0.9251634
GO:0042770 signal transduction in response to DNA damage 122 3 0.9251634
GO:2000379 positive regulation of reactive oxygen species metabolic process 34 2 0.9683649
GO:0071479 cellular response to ionizing radiation 46 2 0.9683649
GO:0071214 cellular response to abiotic stimulus 208 3 0.9683649

traits/peer_k03_S_Insu_30_all_genes.txt

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Number of significant GO categories: 61

Number of DE genes: 7260

category term numInCat numDEInCat q.value
GO:0006414 translational elongation 121 86 0.0000000
GO:0006413 translational initiation 167 110 0.0000000
GO:0006415 translational termination 95 71 0.0000000
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay 118 80 0.0000000
GO:0006614 SRP-dependent cotranslational protein targeting to membrane 107 73 0.0000000
GO:0006613 cotranslational protein targeting to membrane 109 74 0.0000000
GO:0045047 protein targeting to ER 110 74 0.0000001
GO:0043624 cellular protein complex disassembly 174 107 0.0000001
GO:0072599 establishment of protein localization to endoplasmic reticulum 111 74 0.0000001
GO:0006612 protein targeting to membrane 171 104 0.0000003
GO:0043241 protein complex disassembly 195 115 0.0000006
GO:0070972 protein localization to endoplasmic reticulum 128 80 0.0000029
GO:0032984 macromolecular complex disassembly 205 117 0.0000035
GO:0002757 immune response-activating signal transduction 333 176 0.0000102
GO:0006412 translation 496 242 0.0000331
GO:0045321 leukocyte activation 561 269 0.0000900
GO:0019083 viral transcription 158 90 0.0001470
GO:0044033 multi-organism metabolic process 178 99 0.0001887
GO:0019080 viral gene expression 168 94 0.0002325
GO:0002253 activation of immune response 373 187 0.0002477

traits/peer_k03_S_Insu_all_genes.txt

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Number of significant GO categories: 87

Number of DE genes: 8320

category term numInCat numDEInCat q.value
GO:0006413 translational initiation 167 125 0.0e+00
GO:0006614 SRP-dependent cotranslational protein targeting to membrane 107 88 0.0e+00
GO:0006414 translational elongation 121 97 0.0e+00
GO:0006613 cotranslational protein targeting to membrane 109 89 0.0e+00
GO:0072599 establishment of protein localization to endoplasmic reticulum 111 90 0.0e+00
GO:0045047 protein targeting to ER 110 89 0.0e+00
GO:0006415 translational termination 95 79 0.0e+00
GO:0070972 protein localization to endoplasmic reticulum 128 99 0.0e+00
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay 118 93 0.0e+00
GO:0006612 protein targeting to membrane 171 120 0.0e+00
GO:0000956 nuclear-transcribed mRNA catabolic process 184 123 0.0e+00
GO:0019083 viral transcription 158 108 0.0e+00
GO:0006955 immune response 1137 589 0.0e+00
GO:0006401 RNA catabolic process 222 142 0.0e+00
GO:0006402 mRNA catabolic process 196 128 1.0e-07
GO:0019080 viral gene expression 168 110 5.0e-07
GO:0044033 multi-organism metabolic process 178 115 7.0e-07
GO:0002757 immune response-activating signal transduction 333 197 8.0e-07
GO:0045321 leukocyte activation 561 307 1.5e-06
GO:0046649 lymphocyte activation 480 267 2.2e-06

traits/peer_k03_S_LipoA1_all_genes.txt

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Number of significant GO categories: 0

Number of DE genes: 1700

category term numInCat numDEInCat q.value
GO:0006091 generation of precursor metabolites and energy 394 62 0.1567492
GO:0070544 histone H3-K36 demethylation 6 5 0.5072448
GO:0016570 histone modification 343 57 0.5072448
GO:0016569 covalent chromatin modification 348 57 0.5619867
GO:0006096 glycolytic process 57 15 0.6406476

traits/peer_k04_B_GHb_A1C_all_genes.txt

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Number of significant GO categories: 0

Number of DE genes: 30

category term numInCat numDEInCat q.value
GO:0046784 viral mRNA export from host cell nucleus 8 2 0.7166048
GO:0043353 enucleate erythrocyte differentiation 8 2 0.7166048
GO:0042559 pteridine-containing compound biosynthetic process 15 2 0.8636307
GO:0007064 mitotic sister chromatid cohesion 14 2 0.9602701
GO:0030218 erythrocyte differentiation 95 3 0.9602701

traits/peer_k04_daily_energy_expenditure_all_genes.txt

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Number of significant GO categories: 0

Number of DE genes: 748

category term numInCat numDEInCat q.value
GO:0016568 chromatin modification 502 41 1
GO:0006325 chromatin organization 563 43 1
GO:0016570 histone modification 343 30 1
GO:0016569 covalent chromatin modification 348 30 1
GO:2000112 regulation of cellular macromolecule biosynthetic process 3129 168 1

traits/peer_k06_S_GT_all_genes.txt

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Number of significant GO categories: 0

Number of DE genes: 294

category term numInCat numDEInCat q.value
GO:0051188 cofactor biosynthetic process 132 9 1
GO:0038083 peptidyl-tyrosine autophosphorylation 9 3 1
GO:0035634 response to stilbenoid 3 2 1
GO:0051186 cofactor metabolic process 249 12 1
GO:0033013 tetrapyrrole metabolic process 50 5 1

traits/peer_k06_S_LipoB_all_genes.txt

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Number of significant GO categories: 0

Number of DE genes: 12

category term numInCat numDEInCat q.value
GO:0006533 aspartate catabolic process 4 1 1
GO:0015888 thiamine transport 4 1 1
GO:0006531 aspartate metabolic process 7 1 1
GO:0048714 positive regulation of oligodendrocyte differentiation 7 1 1
GO:0016054 organic acid catabolic process 189 2 1

traits/peer_k07_SBP_all_genes.txt

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Number of significant GO categories: 0

Number of DE genes: 56

category term numInCat numDEInCat q.value
GO:0009887 organ morphogenesis 691 11 0.3854763
GO:0060509 Type I pneumocyte differentiation 6 2 0.9310443
GO:0006631 fatty acid metabolic process 281 6 0.9310443
GO:0010831 positive regulation of myotube differentiation 10 2 0.9310443
GO:0030855 epithelial cell differentiation 412 7 0.9310443

ngt_vs_t2d/peer_k03_all_genes.txt

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Number of significant GO categories: 3

Number of DE genes: 320

category term numInCat numDEInCat q.value
GO:0022904 respiratory electron transport chain 105 11 0.0048269
GO:0022900 electron transport chain 106 11 0.0048269
GO:0045333 cellular respiration 158 13 0.0075522
GO:0006120 mitochondrial electron transport, NADH to ubiquinone 42 6 0.1179422
GO:0042773 ATP synthesis coupled electron transport 54 6 0.3650270