This is an initial analysis of GO term enrichment for DE results from all traits that we analyzed.

For this report we called the top 1000 genes as differentially expressed. We display at minimum 5 categories for each trait, and at most 20, ordered by significance.

This report was last generated on Tue May 12 10:40:13 PM 2015

age/peer_k00_age_biopsy_all_genes.txt

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Number of significant GO categories: 81

Number of DE genes: 1000

category term numInCat numDEInCat q.value
GO:0090304 nucleic acid metabolic process 4166 362 0.0e+00
GO:0016070 RNA metabolic process 3693 317 0.0e+00
GO:0006396 RNA processing 676 91 0.0e+00
GO:0000375 RNA splicing, via transesterification reactions 225 44 0.0e+00
GO:0006397 mRNA processing 404 63 0.0e+00
GO:0008380 RNA splicing 332 55 0.0e+00
GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 220 42 0.0e+00
GO:0000398 mRNA splicing, via spliceosome 220 42 0.0e+00
GO:0010467 gene expression 4322 343 0.0e+00
GO:0006139 nucleobase-containing compound metabolic process 5435 411 0.0e+00
GO:0046483 heterocycle metabolic process 5565 417 0.0e+00
GO:1901360 organic cyclic compound metabolic process 5728 423 2.0e-07
GO:0006725 cellular aromatic compound metabolic process 5569 413 2.0e-07
GO:0034641 cellular nitrogen compound metabolic process 5755 422 5.0e-07
GO:0016071 mRNA metabolic process 615 73 8.0e-07
GO:0044260 cellular macromolecule metabolic process 6484 464 8.0e-07
GO:0006351 transcription, DNA-templated 2952 245 1.2e-06
GO:0051252 regulation of RNA metabolic process 2966 246 1.3e-06
GO:0010468 regulation of gene expression 3465 277 2.5e-06
GO:0043170 macromolecule metabolic process 7144 496 6.9e-06

sex/peer_k00_sex_all_genes.txt

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Number of significant GO categories: 19

Number of DE genes: 1000

category term numInCat numDEInCat q.value
GO:0090304 nucleic acid metabolic process 4166 302 0.0002051
GO:0010467 gene expression 4322 306 0.0007478
GO:0016070 RNA metabolic process 3693 266 0.0018154
GO:0000375 RNA splicing, via transesterification reactions 225 32 0.0019483
GO:0008380 RNA splicing 332 41 0.0027391
GO:0010468 regulation of gene expression 3465 251 0.0056069
GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 220 30 0.0056069
GO:0000398 mRNA splicing, via spliceosome 220 30 0.0056069
GO:0044260 cellular macromolecule metabolic process 6484 421 0.0234970
GO:0006139 nucleobase-containing compound metabolic process 5435 361 0.0273017
GO:0006807 nitrogen compound metabolic process 6075 397 0.0273017
GO:1901360 organic cyclic compound metabolic process 5728 377 0.0273017
GO:0034641 cellular nitrogen compound metabolic process 5755 378 0.0279927
GO:2000112 regulation of cellular macromolecule biosynthetic process 3129 225 0.0279927
GO:0016071 mRNA metabolic process 615 58 0.0279927
GO:0046483 heterocycle metabolic process 5565 367 0.0279927
GO:0006725 cellular aromatic compound metabolic process 5569 367 0.0279927
GO:0006397 mRNA processing 404 43 0.0286875
GO:0048704 embryonic skeletal system morphogenesis 84 15 0.0332531

smoking/peer_k01_smoking_all_genes.txt

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Number of significant GO categories: 23

Number of DE genes: 1000

category term numInCat numDEInCat q.value
GO:0045333 cellular respiration 158 36 0.0000000
GO:0006091 generation of precursor metabolites and energy 394 59 0.0000000
GO:0015980 energy derivation by oxidation of organic compounds 319 49 0.0000000
GO:0055114 oxidation-reduction process 896 96 0.0000000
GO:0022904 respiratory electron transport chain 105 25 0.0000000
GO:0022900 electron transport chain 106 25 0.0000000
GO:0009060 aerobic respiration 46 16 0.0000012
GO:0006099 tricarboxylic acid cycle 28 11 0.0001586
GO:0006754 ATP biosynthetic process 36 11 0.0012299
GO:0006119 oxidative phosphorylation 70 15 0.0012299
GO:0009127 purine nucleoside monophosphate biosynthetic process 61 13 0.0113565
GO:0009168 purine ribonucleoside monophosphate biosynthetic process 61 13 0.0113565
GO:0009206 purine ribonucleoside triphosphate biosynthetic process 46 11 0.0123834
GO:0015985 energy coupled proton transport, down electrochemical gradient 19 7 0.0123834
GO:0015986 ATP synthesis coupled proton transport 19 7 0.0123834
GO:0009145 purine nucleoside triphosphate biosynthetic process 47 11 0.0133651
GO:0009156 ribonucleoside monophosphate biosynthetic process 73 14 0.0144337
GO:0042776 mitochondrial ATP synthesis coupled proton transport 14 6 0.0166393
GO:0042773 ATP synthesis coupled electron transport 54 11 0.0250247
GO:0042775 mitochondrial ATP synthesis coupled electron transport 54 11 0.0250247

traits/peer_k00_DBP_all_genes.txt

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Number of significant GO categories: 114

Number of DE genes: 1000

category term numInCat numDEInCat q.value
GO:0045333 cellular respiration 158 79 0
GO:0022904 respiratory electron transport chain 105 59 0
GO:0022900 electron transport chain 106 59 0
GO:0006091 generation of precursor metabolites and energy 394 99 0
GO:0055114 oxidation-reduction process 896 150 0
GO:0015980 energy derivation by oxidation of organic compounds 319 88 0
GO:0006119 oxidative phosphorylation 70 35 0
GO:0042773 ATP synthesis coupled electron transport 54 31 0
GO:0042775 mitochondrial ATP synthesis coupled electron transport 54 31 0
GO:0009060 aerobic respiration 46 26 0
GO:0006120 mitochondrial electron transport, NADH to ubiquinone 42 25 0
GO:0006099 tricarboxylic acid cycle 28 20 0
GO:0044281 small molecule metabolic process 2955 240 0
GO:1902600 hydrogen ion transmembrane transport 84 28 0
GO:0015992 proton transport 112 30 0
GO:0006818 hydrogen transport 114 30 0
GO:0009123 nucleoside monophosphate metabolic process 489 62 0
GO:0009161 ribonucleoside monophosphate metabolic process 478 61 0
GO:0046034 ATP metabolic process 442 57 0
GO:0009167 purine ribonucleoside monophosphate metabolic process 466 59 0

traits/peer_k00_fS_Kol_all_genes.txt

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Number of significant GO categories: 0

Number of DE genes: 1000

category term numInCat numDEInCat q.value
GO:0008380 RNA splicing 332 33 0.5780888
GO:0016070 RNA metabolic process 3693 231 0.5780888
GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 220 24 0.5780888
GO:0000398 mRNA splicing, via spliceosome 220 24 0.5780888
GO:0000375 RNA splicing, via transesterification reactions 225 24 0.6114353

traits/peer_k00_fS_Kol_LDL_c_all_genes.txt

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Number of significant GO categories: 32

Number of DE genes: 1000

category term numInCat numDEInCat q.value
GO:0016070 RNA metabolic process 3693 255 0.0013100
GO:0090304 nucleic acid metabolic process 4166 279 0.0013100
GO:0010467 gene expression 4322 282 0.0114895
GO:0006351 transcription, DNA-templated 2952 208 0.0114895
GO:0051252 regulation of RNA metabolic process 2966 209 0.0114895
GO:1901576 organic substance biosynthetic process 4830 308 0.0114895
GO:0031323 regulation of cellular metabolic process 4749 311 0.0130664
GO:2001141 regulation of RNA biosynthetic process 2888 203 0.0130664
GO:0044249 cellular biosynthetic process 4756 303 0.0131211
GO:0032774 RNA biosynthetic process 3063 211 0.0131211
GO:0051171 regulation of nitrogen compound metabolic process 3754 255 0.0131211
GO:0019222 regulation of metabolic process 5252 337 0.0131211
GO:0006355 regulation of transcription, DNA-templated 2851 200 0.0131211
GO:0009058 biosynthetic process 4899 309 0.0137593
GO:0034641 cellular nitrogen compound metabolic process 5755 357 0.0245738
GO:0060255 regulation of macromolecule metabolic process 4402 285 0.0245738
GO:0010468 regulation of gene expression 3465 233 0.0246407
GO:0031326 regulation of cellular biosynthetic process 3340 225 0.0250738
GO:0034654 nucleobase-containing compound biosynthetic process 3350 223 0.0250738
GO:0009889 regulation of biosynthetic process 3367 226 0.0250738

traits/peer_k00_fS_Krea_all_genes.txt

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Number of significant GO categories: 12

Number of DE genes: 1000

category term numInCat numDEInCat q.value
GO:0010467 gene expression 4322 286 0.0002599
GO:0090304 nucleic acid metabolic process 4166 276 0.0002599
GO:0016070 RNA metabolic process 3693 247 0.0006156
GO:0006351 transcription, DNA-templated 2952 199 0.0187893
GO:0032774 RNA biosynthetic process 3063 203 0.0366136
GO:0010556 regulation of macromolecule biosynthetic process 3214 211 0.0379310
GO:0009889 regulation of biosynthetic process 3367 219 0.0380725
GO:0051252 regulation of RNA metabolic process 2966 196 0.0396841
GO:0043170 macromolecule metabolic process 7144 417 0.0396841
GO:0006355 regulation of transcription, DNA-templated 2851 189 0.0396841
GO:2001141 regulation of RNA biosynthetic process 2888 191 0.0396841
GO:0031326 regulation of cellular biosynthetic process 3340 216 0.0396841

traits/peer_k00_GL30_all_genes.txt

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Number of significant GO categories: 56

Number of DE genes: 1000

category term numInCat numDEInCat q.value
GO:0045333 cellular respiration 158 43 0.0000000
GO:0022904 respiratory electron transport chain 105 33 0.0000000
GO:0022900 electron transport chain 106 33 0.0000000
GO:0006091 generation of precursor metabolites and energy 394 66 0.0000000
GO:0015980 energy derivation by oxidation of organic compounds 319 57 0.0000000
GO:1902600 hydrogen ion transmembrane transport 84 26 0.0000000
GO:0055114 oxidation-reduction process 896 103 0.0000000
GO:0015992 proton transport 112 26 0.0000001
GO:0006818 hydrogen transport 114 26 0.0000002
GO:0006119 oxidative phosphorylation 70 20 0.0000003
GO:0042773 ATP synthesis coupled electron transport 54 17 0.0000008
GO:0042775 mitochondrial ATP synthesis coupled electron transport 54 17 0.0000008
GO:0044281 small molecule metabolic process 2955 232 0.0000022
GO:0015985 energy coupled proton transport, down electrochemical gradient 19 10 0.0000064
GO:0015986 ATP synthesis coupled proton transport 19 10 0.0000064
GO:0006120 mitochondrial electron transport, NADH to ubiquinone 42 14 0.0000076
GO:0009145 purine nucleoside triphosphate biosynthetic process 47 14 0.0000766
GO:0006164 purine nucleotide biosynthetic process 191 30 0.0001305
GO:0009152 purine ribonucleotide biosynthetic process 185 29 0.0002028
GO:0009260 ribonucleotide biosynthetic process 198 30 0.0002669

traits/peer_k00_ratio_apob_apoa1_all_genes.txt

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Number of significant GO categories: 290

Number of DE genes: 1000

category term numInCat numDEInCat q.value
GO:0006955 immune response 1137 145 0
GO:0045321 leukocyte activation 561 95 0
GO:0002376 immune system process 1936 204 0
GO:0046649 lymphocyte activation 480 84 0
GO:0001775 cell activation 767 109 0
GO:0042110 T cell activation 347 65 0
GO:0002682 regulation of immune system process 997 120 0
GO:0050776 regulation of immune response 666 86 0
GO:0006952 defense response 1178 124 0
GO:0002694 regulation of leukocyte activation 340 55 0
GO:0002684 positive regulation of immune system process 610 79 0
GO:0050865 regulation of cell activation 366 56 0
GO:0002521 leukocyte differentiation 353 55 0
GO:0002252 immune effector process 504 68 0
GO:0051249 regulation of lymphocyte activation 298 49 0
GO:0030098 lymphocyte differentiation 235 43 0
GO:0002757 immune response-activating signal transduction 333 52 0
GO:0045087 innate immune response 724 84 0
GO:0002253 activation of immune response 373 55 0
GO:0050851 antigen receptor-mediated signaling pathway 138 31 0

traits/peer_k00_S_Ca_30_all_genes.txt

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Number of significant GO categories: 0

Number of DE genes: 1000

category term numInCat numDEInCat q.value
GO:0065008 regulation of biological quality 2575 217 0.1164611
GO:0048518 positive regulation of biological process 3684 294 0.1164611
GO:0044699 single-organism process 10471 725 0.1619872
GO:0044711 single-organism biosynthetic process 1254 112 0.1810312
GO:0006289 nucleotide-excision repair 80 15 0.2917360

traits/peer_k00_total_daily_physical_activity_all_genes.txt

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Number of significant GO categories: 33

Number of DE genes: 1000

category term numInCat numDEInCat q.value
GO:0051252 regulation of RNA metabolic process 2966 203 0.0001339
GO:0031326 regulation of cellular biosynthetic process 3340 223 0.0001339
GO:0009889 regulation of biosynthetic process 3367 224 0.0001339
GO:0051171 regulation of nitrogen compound metabolic process 3754 245 0.0001339
GO:0010468 regulation of gene expression 3465 228 0.0001339
GO:0019219 regulation of nucleobase-containing compound metabolic process 3668 239 0.0001339
GO:0010556 regulation of macromolecule biosynthetic process 3214 214 0.0001339
GO:2001141 regulation of RNA biosynthetic process 2888 196 0.0001339
GO:0016070 RNA metabolic process 3693 239 0.0001339
GO:0006355 regulation of transcription, DNA-templated 2851 194 0.0001339
GO:2000112 regulation of cellular macromolecule biosynthetic process 3129 209 0.0001355
GO:0006351 transcription, DNA-templated 2952 198 0.0002160
GO:0090304 nucleic acid metabolic process 4166 261 0.0003140
GO:0032774 RNA biosynthetic process 3063 202 0.0003925
GO:0034641 cellular nitrogen compound metabolic process 5755 338 0.0036723
GO:0019222 regulation of metabolic process 5252 313 0.0036723
GO:0080090 regulation of primary metabolic process 4733 286 0.0047459
GO:0060255 regulation of macromolecule metabolic process 4402 268 0.0054160
GO:0010467 gene expression 4322 263 0.0057420
GO:0031323 regulation of cellular metabolic process 4749 286 0.0057420

traits/peer_k01_fS_Trigly_all_genes.txt

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Number of significant GO categories: 18

Number of DE genes: 1000

category term numInCat numDEInCat q.value
GO:0055114 oxidation-reduction process 896 87 0.0011944
GO:0006413 translational initiation 167 27 0.0018574
GO:0044283 small molecule biosynthetic process 388 46 0.0061302
GO:0070972 protein localization to endoplasmic reticulum 128 21 0.0108581
GO:0072599 establishment of protein localization to endoplasmic reticulum 111 19 0.0108581
GO:0019752 carboxylic acid metabolic process 829 78 0.0108581
GO:0006614 SRP-dependent cotranslational protein targeting to membrane 107 18 0.0189804
GO:0044262 cellular carbohydrate metabolic process 248 32 0.0189804
GO:0006613 cotranslational protein targeting to membrane 109 18 0.0189804
GO:0045047 protein targeting to ER 110 18 0.0189804
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay 118 19 0.0189804
GO:0009063 cellular amino acid catabolic process 103 18 0.0189804
GO:0006082 organic acid metabolic process 944 84 0.0205173
GO:0006415 translational termination 95 16 0.0281822
GO:0043436 oxoacid metabolic process 934 82 0.0342212
GO:0044282 small molecule catabolic process 242 30 0.0342212
GO:0032787 monocarboxylic acid metabolic process 427 45 0.0342212
GO:0006090 pyruvate metabolic process 81 15 0.0342578

traits/peer_k01_GL120_all_genes.txt

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Number of significant GO categories: 1

Number of DE genes: 1000

category term numInCat numDEInCat q.value
GO:0044267 cellular protein metabolic process 3491 261 0.0025144
GO:0019538 protein metabolic process 4128 288 0.2285944
GO:0006412 translation 496 48 0.2985691
GO:0016310 phosphorylation 1655 130 0.2985691
GO:0006614 SRP-dependent cotranslational protein targeting to membrane 107 16 0.2985691

traits/peer_k01_GL60_all_genes.txt

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Number of significant GO categories: 8

Number of DE genes: 1000

category term numInCat numDEInCat q.value
GO:0055114 oxidation-reduction process 896 87 0.0008501
GO:0045333 cellular respiration 158 25 0.0028891
GO:0015980 energy derivation by oxidation of organic compounds 319 40 0.0028891
GO:0006091 generation of precursor metabolites and energy 394 45 0.0064344
GO:0022904 respiratory electron transport chain 105 18 0.0085035
GO:0022900 electron transport chain 106 18 0.0085035
GO:0071482 cellular response to light stimulus 74 15 0.0241262
GO:0071478 cellular response to radiation 116 19 0.0382964

traits/peer_k01_S_ALAT_all_genes.txt

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Number of significant GO categories: 0

Number of DE genes: 1000

category term numInCat numDEInCat q.value
GO:0044699 single-organism process 10471 591 0.7072368
GO:0007342 fusion of sperm to egg plasma membrane 8 4 1.0000000
GO:0044763 single-organism cellular process 9511 538 1.0000000
GO:0071435 potassium ion export 9 4 1.0000000
GO:0090083 regulation of inclusion body assembly 15 5 1.0000000

traits/peer_k01_S_hs_CRP_all_genes.txt

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Number of significant GO categories: 33

Number of DE genes: 1000

category term numInCat numDEInCat q.value
GO:0023052 signaling 4496 308 0.0045212
GO:0044700 single organism signaling 4496 308 0.0045212
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway 646 66 0.0045212
GO:0007154 cell communication 4559 309 0.0088043
GO:0043085 positive regulation of catalytic activity 1225 104 0.0139460
GO:0001525 angiogenesis 350 40 0.0175962
GO:0044093 positive regulation of molecular function 1425 116 0.0209938
GO:0048514 blood vessel morphogenesis 421 45 0.0220078
GO:0038127 ERBB signaling pathway 219 29 0.0220078
GO:0007165 signal transduction 4077 276 0.0228293
GO:0007167 enzyme linked receptor protein signaling pathway 890 79 0.0228293
GO:0001568 blood vessel development 480 49 0.0228293
GO:0007173 epidermal growth factor receptor signaling pathway 213 28 0.0228293
GO:0001944 vasculature development 509 51 0.0228293
GO:0032501 multicellular organismal process 4965 326 0.0253588
GO:1901700 response to oxygen-containing compound 1037 86 0.0314747
GO:0035556 intracellular signal transduction 1995 149 0.0335943
GO:0000302 response to reactive oxygen species 140 20 0.0350047
GO:0000303 response to superoxide 20 7 0.0350047
GO:0044707 single-multicellular organism process 4822 316 0.0350047

traits/peer_k01_strenuous_physical_activity_all_genes.txt

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Number of significant GO categories: 0

Number of DE genes: 1000

category term numInCat numDEInCat q.value
GO:0051877 pigment granule aggregation in cell center 3 3 1
GO:0006489 dolichyl diphosphate biosynthetic process 5 3 1
GO:0046465 dolichyl diphosphate metabolic process 5 3 1
GO:0002317 plasma cell differentiation 2 2 1
GO:0043615 astrocyte cell migration 6 3 1

traits/peer_k01_S_Uraat_all_genes.txt

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Number of significant GO categories: 6

Number of DE genes: 1000

category term numInCat numDEInCat q.value
GO:0055114 oxidation-reduction process 896 82 0.0142659
GO:0030595 leukocyte chemotaxis 130 21 0.0205126
GO:0002690 positive regulation of leukocyte chemotaxis 50 12 0.0225959
GO:0002687 positive regulation of leukocyte migration 70 14 0.0312499
GO:0002688 regulation of leukocyte chemotaxis 62 13 0.0341690
GO:0097529 myeloid leukocyte migration 104 17 0.0482581

traits/peer_k01_WHR_all_genes.txt

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Number of significant GO categories: 1

Number of DE genes: 1000

category term numInCat numDEInCat q.value
GO:1901342 regulation of vasculature development 172 26 0.0431701
GO:0045765 regulation of angiogenesis 158 23 0.1401978
GO:0032409 regulation of transporter activity 130 20 0.2030731
GO:0009888 tissue development 1345 110 0.2030731
GO:0003012 muscle system process 299 33 0.3182768

traits/peer_k03_bmi_all_genes.txt

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Number of significant GO categories: 99

Number of DE genes: 1000

category term numInCat numDEInCat q.value
GO:0006614 SRP-dependent cotranslational protein targeting to membrane 107 47 0
GO:0006414 translational elongation 121 50 0
GO:0006613 cotranslational protein targeting to membrane 109 47 0
GO:0006415 translational termination 95 44 0
GO:0045047 protein targeting to ER 110 47 0
GO:0072599 establishment of protein localization to endoplasmic reticulum 111 47 0
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay 118 48 0
GO:0070972 protein localization to endoplasmic reticulum 128 49 0
GO:0006413 translational initiation 167 54 0
GO:0043624 cellular protein complex disassembly 174 53 0
GO:0043241 protein complex disassembly 195 55 0
GO:0006612 protein targeting to membrane 171 51 0
GO:0032984 macromolecular complex disassembly 205 56 0
GO:0000956 nuclear-transcribed mRNA catabolic process 184 53 0
GO:0006402 mRNA catabolic process 196 53 0
GO:0006412 translation 496 88 0
GO:0019083 viral transcription 158 46 0
GO:0019080 viral gene expression 168 46 0
GO:0006401 RNA catabolic process 222 54 0
GO:0044033 multi-organism metabolic process 178 46 0

traits/peer_k03_fS_C_pept_30_all_genes.txt

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Number of significant GO categories: 51

Number of DE genes: 1000

category term numInCat numDEInCat q.value
GO:0006415 translational termination 95 34 0e+00
GO:0006413 translational initiation 167 45 0e+00
GO:0006414 translational elongation 121 38 0e+00
GO:0006614 SRP-dependent cotranslational protein targeting to membrane 107 35 0e+00
GO:0006613 cotranslational protein targeting to membrane 109 35 0e+00
GO:0070972 protein localization to endoplasmic reticulum 128 38 0e+00
GO:0045047 protein targeting to ER 110 35 0e+00
GO:0072599 establishment of protein localization to endoplasmic reticulum 111 35 0e+00
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay 118 36 0e+00
GO:0019083 viral transcription 158 39 0e+00
GO:0019080 viral gene expression 168 39 0e+00
GO:0044033 multi-organism metabolic process 178 39 0e+00
GO:0043241 protein complex disassembly 195 41 0e+00
GO:0043624 cellular protein complex disassembly 174 38 0e+00
GO:0006612 protein targeting to membrane 171 37 0e+00
GO:0032984 macromolecular complex disassembly 205 41 0e+00
GO:0000956 nuclear-transcribed mRNA catabolic process 184 37 0e+00
GO:0006402 mRNA catabolic process 196 38 0e+00
GO:0006412 translation 496 65 1e-07
GO:0006401 RNA catabolic process 222 39 1e-07

traits/peer_k03_fS_C_pept_all_genes.txt

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Number of significant GO categories: 85

Number of DE genes: 1000

category term numInCat numDEInCat q.value
GO:0006414 translational elongation 121 53 0
GO:0006415 translational termination 95 47 0
GO:0006613 cotranslational protein targeting to membrane 109 49 0
GO:0045047 protein targeting to ER 110 49 0
GO:0072599 establishment of protein localization to endoplasmic reticulum 111 49 0
GO:0006614 SRP-dependent cotranslational protein targeting to membrane 107 48 0
GO:0070972 protein localization to endoplasmic reticulum 128 51 0
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay 118 49 0
GO:0006413 translational initiation 167 57 0
GO:0043624 cellular protein complex disassembly 174 57 0
GO:0043241 protein complex disassembly 195 58 0
GO:0019083 viral transcription 158 51 0
GO:0006612 protein targeting to membrane 171 53 0
GO:0032984 macromolecular complex disassembly 205 58 0
GO:0019080 viral gene expression 168 51 0
GO:0044033 multi-organism metabolic process 178 51 0
GO:0006412 translation 496 86 0
GO:0000956 nuclear-transcribed mRNA catabolic process 184 49 0
GO:0006402 mRNA catabolic process 196 50 0
GO:0006401 RNA catabolic process 222 51 0

traits/peer_k03_fS_Kol_HDL_all_genes.txt

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Number of significant GO categories: 21

Number of DE genes: 1000

category term numInCat numDEInCat q.value
GO:0006413 translational initiation 167 32 0.0000008
GO:0006415 translational termination 95 23 0.0000008
GO:0006414 translational elongation 121 26 0.0000013
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay 118 25 0.0000042
GO:0006614 SRP-dependent cotranslational protein targeting to membrane 107 23 0.0000047
GO:0006613 cotranslational protein targeting to membrane 109 23 0.0000059
GO:0045047 protein targeting to ER 110 23 0.0000059
GO:0072599 establishment of protein localization to endoplasmic reticulum 111 23 0.0000065
GO:0070972 protein localization to endoplasmic reticulum 128 25 0.0000065
GO:0006412 translation 496 56 0.0000811
GO:0043624 cellular protein complex disassembly 174 28 0.0001855
GO:0043241 protein complex disassembly 195 30 0.0001871
GO:0032984 macromolecular complex disassembly 205 30 0.0005173
GO:0019083 viral transcription 158 24 0.0014245
GO:0044033 multi-organism metabolic process 178 25 0.0039336
GO:0019080 viral gene expression 168 24 0.0039621
GO:0000956 nuclear-transcribed mRNA catabolic process 184 26 0.0042741
GO:0006402 mRNA catabolic process 196 27 0.0050576
GO:0006401 RNA catabolic process 222 29 0.0065980
GO:0006612 protein targeting to membrane 171 24 0.0072926

traits/peer_k03_GL0_all_genes.txt

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Number of significant GO categories: 19

Number of DE genes: 1000

category term numInCat numDEInCat q.value
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay 118 24 0.0000879
GO:0006413 translational initiation 167 27 0.0009286
GO:0000956 nuclear-transcribed mRNA catabolic process 184 28 0.0018665
GO:0006402 mRNA catabolic process 196 29 0.0018665
GO:0006415 translational termination 95 18 0.0023109
GO:0006614 SRP-dependent cotranslational protein targeting to membrane 107 19 0.0030895
GO:0006613 cotranslational protein targeting to membrane 109 19 0.0031030
GO:0044265 cellular macromolecule catabolic process 798 76 0.0031030
GO:0045047 protein targeting to ER 110 19 0.0031030
GO:0072599 establishment of protein localization to endoplasmic reticulum 111 19 0.0031030
GO:0006401 RNA catabolic process 222 30 0.0031030
GO:0019395 fatty acid oxidation 77 16 0.0049262
GO:0034440 lipid oxidation 79 16 0.0061323
GO:0070972 protein localization to endoplasmic reticulum 128 20 0.0066649
GO:0030258 lipid modification 149 23 0.0096007
GO:0006414 translational elongation 121 19 0.0099756
GO:0009057 macromolecule catabolic process 983 85 0.0215113
GO:0019083 viral transcription 158 21 0.0423193
GO:0016071 mRNA metabolic process 615 57 0.0439366

traits/peer_k03_S_Ca_all_genes.txt

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Number of significant GO categories: 0

Number of DE genes: 1000

category term numInCat numDEInCat q.value
GO:0033993 response to lipid 568 46 1
GO:0046928 regulation of neurotransmitter secretion 40 8 1
GO:0051046 regulation of secretion 431 37 1
GO:0009893 positive regulation of metabolic process 2104 137 1
GO:0035924 cellular response to vascular endothelial growth factor stimulus 31 7 1

traits/peer_k03_S_Insu_30_all_genes.txt

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Number of significant GO categories: 54

Number of DE genes: 1000

category term numInCat numDEInCat q.value
GO:0006413 translational initiation 167 37 0.00e+00
GO:0006414 translational elongation 121 30 0.00e+00
GO:0006415 translational termination 95 26 0.00e+00
GO:0070972 protein localization to endoplasmic reticulum 128 30 0.00e+00
GO:0006614 SRP-dependent cotranslational protein targeting to membrane 107 27 0.00e+00
GO:0006613 cotranslational protein targeting to membrane 109 27 0.00e+00
GO:0045047 protein targeting to ER 110 27 0.00e+00
GO:0072599 establishment of protein localization to endoplasmic reticulum 111 27 0.00e+00
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay 118 27 2.00e-07
GO:0006091 generation of precursor metabolites and energy 394 54 1.00e-06
GO:0019083 viral transcription 158 30 2.00e-06
GO:0043241 protein complex disassembly 195 34 3.60e-06
GO:0055114 oxidation-reduction process 896 93 5.10e-06
GO:0019080 viral gene expression 168 30 7.20e-06
GO:0006412 translation 496 60 9.20e-06
GO:0032984 macromolecular complex disassembly 205 34 9.50e-06
GO:0044033 multi-organism metabolic process 178 30 2.49e-05
GO:0043624 cellular protein complex disassembly 174 30 2.49e-05
GO:0015980 energy derivation by oxidation of organic compounds 319 43 5.29e-05
GO:0019752 carboxylic acid metabolic process 829 84 1.14e-04

traits/peer_k03_S_Insu_all_genes.txt

plot of chunk unnamed-chunk-79

Number of significant GO categories: 63

Number of DE genes: 1000

category term numInCat numDEInCat q.value
GO:0006415 translational termination 95 43 0
GO:0006613 cotranslational protein targeting to membrane 109 45 0
GO:0045047 protein targeting to ER 110 45 0
GO:0072599 establishment of protein localization to endoplasmic reticulum 111 45 0
GO:0006614 SRP-dependent cotranslational protein targeting to membrane 107 44 0
GO:0070972 protein localization to endoplasmic reticulum 128 48 0
GO:0006414 translational elongation 121 46 0
GO:0006413 translational initiation 167 53 0
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay 118 45 0
GO:0043624 cellular protein complex disassembly 174 51 0
GO:0006612 protein targeting to membrane 171 50 0
GO:0019083 viral transcription 158 47 0
GO:0043241 protein complex disassembly 195 52 0
GO:0019080 viral gene expression 168 47 0
GO:0032984 macromolecular complex disassembly 205 52 0
GO:0044033 multi-organism metabolic process 178 47 0
GO:0006412 translation 496 80 0
GO:0000956 nuclear-transcribed mRNA catabolic process 184 45 0
GO:0006402 mRNA catabolic process 196 46 0
GO:0090150 establishment of protein localization to membrane 296 56 0

traits/peer_k03_S_LipoA1_all_genes.txt

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Number of significant GO categories: 0

Number of DE genes: 1000

category term numInCat numDEInCat q.value
GO:0006091 generation of precursor metabolites and energy 394 43 0.1093453
GO:0005977 glycogen metabolic process 78 14 0.3843142
GO:0010746 regulation of plasma membrane long-chain fatty acid transport 5 4 0.3843142
GO:0006073 cellular glucan metabolic process 79 14 0.3843142
GO:0044042 glucan metabolic process 79 14 0.3843142

traits/peer_k04_B_GHb_A1C_all_genes.txt

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Number of significant GO categories: 0

Number of DE genes: 1000

category term numInCat numDEInCat q.value
GO:0006405 RNA export from nucleus 80 16 0.0646124
GO:0051168 nuclear export 136 21 0.0646124
GO:0050657 nucleic acid transport 144 22 0.0646124
GO:0050658 RNA transport 144 22 0.0646124
GO:0051236 establishment of RNA localization 144 22 0.0646124

traits/peer_k04_daily_energy_expenditure_all_genes.txt

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Number of significant GO categories: 0

Number of DE genes: 1000

category term numInCat numDEInCat q.value
GO:0006325 chromatin organization 563 57 0.3029139
GO:0051253 negative regulation of RNA metabolic process 852 77 0.3029139
GO:0034504 protein localization to nucleus 185 25 0.3029139
GO:0010629 negative regulation of gene expression 916 81 0.3029139
GO:0016568 chromatin modification 502 51 0.3871258

traits/peer_k06_S_GT_all_genes.txt

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Number of significant GO categories: 0

Number of DE genes: 1000

category term numInCat numDEInCat q.value
GO:0001977 renal system process involved in regulation of blood volume 14 6 0.4169497
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity 80 14 0.5423860
GO:0003071 renal system process involved in regulation of systemic arterial blood pressure 20 6 1.0000000
GO:2000781 positive regulation of double-strand break repair 4 3 1.0000000
GO:0003093 regulation of glomerular filtration 10 4 1.0000000

traits/peer_k06_S_LipoB_all_genes.txt

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Number of significant GO categories: 0

Number of DE genes: 1000

category term numInCat numDEInCat q.value
GO:0002526 acute inflammatory response 96 13 1
GO:0005975 carbohydrate metabolic process 751 56 1
GO:0044255 cellular lipid metabolic process 772 57 1
GO:0044723 single-organism carbohydrate metabolic process 589 46 1
GO:0044710 single-organism metabolic process 4810 269 1

traits/peer_k07_SBP_all_genes.txt

plot of chunk unnamed-chunk-97

Number of significant GO categories: 0

Number of DE genes: 1000

category term numInCat numDEInCat q.value
GO:0032819 positive regulation of natural killer cell proliferation 4 3 1
GO:1901701 cellular response to oxygen-containing compound 690 56 1
GO:0046661 male sex differentiation 116 15 1
GO:0014902 myotube differentiation 89 13 1
GO:0032817 regulation of natural killer cell proliferation 5 3 1

ngt_vs_t2d/peer_k03_all_genes.txt

plot of chunk unnamed-chunk-100

Number of significant GO categories: 16

Number of DE genes: 1000

category term numInCat numDEInCat q.value
GO:0022904 respiratory electron transport chain 105 32 0.0000000
GO:0022900 electron transport chain 106 32 0.0000000
GO:0045333 cellular respiration 158 35 0.0000000
GO:1902600 hydrogen ion transmembrane transport 84 21 0.0000020
GO:0055114 oxidation-reduction process 895 90 0.0000148
GO:0006091 generation of precursor metabolites and energy 395 50 0.0000281
GO:0015980 energy derivation by oxidation of organic compounds 319 43 0.0000325
GO:0042773 ATP synthesis coupled electron transport 54 15 0.0000325
GO:0042775 mitochondrial ATP synthesis coupled electron transport 54 15 0.0000325
GO:0015992 proton transport 112 21 0.0002193
GO:0006818 hydrogen transport 114 21 0.0002873
GO:0006120 mitochondrial electron transport, NADH to ubiquinone 42 12 0.0003775
GO:0006119 oxidative phosphorylation 70 15 0.0011039
GO:0015985 energy coupled proton transport, down electrochemical gradient 19 7 0.0124564
GO:0015986 ATP synthesis coupled proton transport 19 7 0.0124564
GO:0042776 mitochondrial ATP synthesis coupled proton transport 14 6 0.0184776