This is an initial analysis of GO term enrichment for DE results from all traits that we analyzed.

For this report we called the top 2000 genes as differentially expressed. We display at minimum 5 categories for each trait, and at most 20, ordered by significance.

This report was last generated on Tue May 12 10:50:07 PM 2015

age/peer_k00_age_biopsy_all_genes.txt

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Number of significant GO categories: 106

Number of DE genes: 2000

category term numInCat numDEInCat q.value
GO:0090304 nucleic acid metabolic process 4166 683 0
GO:0016070 RNA metabolic process 3693 601 0
GO:0006397 mRNA processing 404 115 0
GO:0010467 gene expression 4322 666 0
GO:0006396 RNA processing 676 160 0
GO:0008380 RNA splicing 332 99 0
GO:0000375 RNA splicing, via transesterification reactions 225 74 0
GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 220 72 0
GO:0000398 mRNA splicing, via spliceosome 220 72 0
GO:0044260 cellular macromolecule metabolic process 6484 912 0
GO:0006139 nucleobase-containing compound metabolic process 5435 788 0
GO:0016071 mRNA metabolic process 615 139 0
GO:0046483 heterocycle metabolic process 5565 797 0
GO:0043170 macromolecule metabolic process 7144 980 0
GO:0034645 cellular macromolecule biosynthetic process 3920 593 0
GO:0006725 cellular aromatic compound metabolic process 5569 793 0
GO:0006351 transcription, DNA-templated 2952 471 0
GO:0010468 regulation of gene expression 3465 537 0
GO:1901360 organic cyclic compound metabolic process 5728 809 0
GO:0009059 macromolecule biosynthetic process 4025 601 0

sex/peer_k00_sex_all_genes.txt

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Number of significant GO categories: 43

Number of DE genes: 2000

category term numInCat numDEInCat q.value
GO:0090304 nucleic acid metabolic process 4166 564 0.0001046
GO:0010467 gene expression 4322 575 0.0003814
GO:0016070 RNA metabolic process 3693 500 0.0004735
GO:0044260 cellular macromolecule metabolic process 6484 823 0.0004735
GO:0006325 chromatin organization 563 103 0.0028202
GO:0051276 chromosome organization 738 126 0.0060955
GO:0043170 macromolecule metabolic process 7144 889 0.0060955
GO:0000375 RNA splicing, via transesterification reactions 225 48 0.0070430
GO:0010468 regulation of gene expression 3465 467 0.0072415
GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 220 46 0.0152074
GO:0000398 mRNA splicing, via spliceosome 220 46 0.0152074
GO:0016577 histone demethylation 22 11 0.0162213
GO:0022402 cell cycle process 1086 168 0.0205092
GO:0034622 cellular macromolecular complex assembly 583 97 0.0205092
GO:0034645 cellular macromolecule biosynthetic process 3920 512 0.0205092
GO:0008380 RNA splicing 332 62 0.0205092
GO:0000278 mitotic cell cycle 856 136 0.0205092
GO:0009059 macromolecule biosynthetic process 4025 523 0.0205092
GO:0016568 chromatin modification 502 90 0.0205092
GO:0051252 regulation of RNA metabolic process 2966 401 0.0206766

smoking/peer_k01_smoking_all_genes.txt

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Number of significant GO categories: 17

Number of DE genes: 2000

category term numInCat numDEInCat q.value
GO:0045333 cellular respiration 158 54 0.0000000
GO:0009060 aerobic respiration 46 25 0.0000000
GO:0006091 generation of precursor metabolites and energy 394 89 0.0000000
GO:0022904 respiratory electron transport chain 105 36 0.0000000
GO:0022900 electron transport chain 106 36 0.0000000
GO:0006099 tricarboxylic acid cycle 28 18 0.0000000
GO:0015980 energy derivation by oxidation of organic compounds 319 73 0.0000000
GO:0055114 oxidation-reduction process 896 152 0.0000001
GO:0006119 oxidative phosphorylation 70 22 0.0003924
GO:0044282 small molecule catabolic process 242 51 0.0007716
GO:0016054 organic acid catabolic process 189 41 0.0047168
GO:0046395 carboxylic acid catabolic process 189 41 0.0047168
GO:0042773 ATP synthesis coupled electron transport 54 17 0.0047199
GO:0042775 mitochondrial ATP synthesis coupled electron transport 54 17 0.0047199
GO:0006120 mitochondrial electron transport, NADH to ubiquinone 42 14 0.0125207
GO:0009127 purine nucleoside monophosphate biosynthetic process 61 18 0.0133502
GO:0009168 purine ribonucleoside monophosphate biosynthetic process 61 18 0.0133502

traits/peer_k00_DBP_all_genes.txt

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Number of significant GO categories: 111

Number of DE genes: 2000

category term numInCat numDEInCat q.value
GO:0045333 cellular respiration 158 97 0
GO:0022904 respiratory electron transport chain 105 73 0
GO:0022900 electron transport chain 106 73 0
GO:0015980 energy derivation by oxidation of organic compounds 319 114 0
GO:0006091 generation of precursor metabolites and energy 394 127 0
GO:0055114 oxidation-reduction process 896 209 0
GO:0042773 ATP synthesis coupled electron transport 54 38 0
GO:0042775 mitochondrial ATP synthesis coupled electron transport 54 38 0
GO:0006119 oxidative phosphorylation 70 43 0
GO:0006120 mitochondrial electron transport, NADH to ubiquinone 42 31 0
GO:0009060 aerobic respiration 46 30 0
GO:0006099 tricarboxylic acid cycle 28 23 0
GO:0044281 small molecule metabolic process 2955 395 0
GO:1902600 hydrogen ion transmembrane transport 84 36 0
GO:0006818 hydrogen transport 114 39 0
GO:0042776 mitochondrial ATP synthesis coupled proton transport 14 13 0
GO:0015992 proton transport 112 38 0
GO:0015985 energy coupled proton transport, down electrochemical gradient 19 15 0
GO:0015986 ATP synthesis coupled proton transport 19 15 0
GO:0044710 single-organism metabolic process 4810 563 0

traits/peer_k00_fS_Kol_all_genes.txt

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Number of significant GO categories: 0

Number of DE genes: 2000

category term numInCat numDEInCat q.value
GO:0090304 nucleic acid metabolic process 4166 484 0.1562748
GO:0006281 DNA repair 393 65 0.1788455
GO:0000305 response to oxygen radical 21 9 0.2808079
GO:0016070 RNA metabolic process 3693 429 0.2808079
GO:0006351 transcription, DNA-templated 2952 350 0.5477384

traits/peer_k00_fS_Kol_LDL_c_all_genes.txt

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Number of significant GO categories: 44

Number of DE genes: 2000

category term numInCat numDEInCat q.value
GO:0016070 RNA metabolic process 3693 495 1.50e-06
GO:0090304 nucleic acid metabolic process 4166 540 7.10e-06
GO:0006139 nucleobase-containing compound metabolic process 5435 678 3.46e-05
GO:0034641 cellular nitrogen compound metabolic process 5755 710 3.63e-05
GO:0051171 regulation of nitrogen compound metabolic process 3754 496 4.17e-05
GO:0034654 nucleobase-containing compound biosynthetic process 3350 441 4.17e-05
GO:0006351 transcription, DNA-templated 2952 399 4.17e-05
GO:0018130 heterocycle biosynthetic process 3413 447 4.17e-05
GO:0006725 cellular aromatic compound metabolic process 5569 687 4.17e-05
GO:0046483 heterocycle metabolic process 5565 686 4.31e-05
GO:0051252 regulation of RNA metabolic process 2966 400 4.31e-05
GO:0044271 cellular nitrogen compound biosynthetic process 3463 451 4.31e-05
GO:0019438 aromatic compound biosynthetic process 3410 445 4.76e-05
GO:1901360 organic cyclic compound metabolic process 5728 701 5.23e-05
GO:0019219 regulation of nucleobase-containing compound metabolic process 3668 483 6.15e-05
GO:1901362 organic cyclic compound biosynthetic process 3503 453 6.15e-05
GO:0010467 gene expression 4322 543 6.15e-05
GO:0006807 nitrogen compound metabolic process 6075 737 6.29e-05
GO:0032774 RNA biosynthetic process 3063 405 7.27e-05
GO:0006355 regulation of transcription, DNA-templated 2851 383 8.18e-05

traits/peer_k00_fS_Krea_all_genes.txt

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Number of significant GO categories: 34

Number of DE genes: 2000

category term numInCat numDEInCat q.value
GO:0090304 nucleic acid metabolic process 4166 530 0.0000013
GO:0010467 gene expression 4322 540 0.0000045
GO:0016070 RNA metabolic process 3693 472 0.0000045
GO:0000375 RNA splicing, via transesterification reactions 225 50 0.0001212
GO:0006396 RNA processing 676 112 0.0001212
GO:0022613 ribonucleoprotein complex biogenesis 280 58 0.0001212
GO:0006139 nucleobase-containing compound metabolic process 5435 644 0.0001640
GO:0006725 cellular aromatic compound metabolic process 5569 657 0.0001912
GO:0042254 ribosome biogenesis 167 40 0.0002246
GO:0034641 cellular nitrogen compound metabolic process 5755 675 0.0002246
GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 220 47 0.0005617
GO:0000398 mRNA splicing, via spliceosome 220 47 0.0005617
GO:0046483 heterocycle metabolic process 5565 652 0.0007085
GO:0006397 mRNA processing 404 72 0.0011396
GO:0008380 RNA splicing 332 62 0.0011396
GO:0006351 transcription, DNA-templated 2952 371 0.0015582
GO:0016072 rRNA metabolic process 122 30 0.0022754
GO:1901360 organic cyclic compound metabolic process 5728 665 0.0027603
GO:0034660 ncRNA metabolic process 325 59 0.0044547
GO:0006364 rRNA processing 117 28 0.0070207

traits/peer_k00_GL30_all_genes.txt

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Number of significant GO categories: 62

Number of DE genes: 2000

category term numInCat numDEInCat q.value
GO:0045333 cellular respiration 158 64 0.0000000
GO:0022904 respiratory electron transport chain 105 47 0.0000000
GO:0022900 electron transport chain 106 47 0.0000000
GO:0006091 generation of precursor metabolites and energy 394 103 0.0000000
GO:0015980 energy derivation by oxidation of organic compounds 319 89 0.0000000
GO:0055114 oxidation-reduction process 896 171 0.0000000
GO:1902600 hydrogen ion transmembrane transport 84 35 0.0000000
GO:0042773 ATP synthesis coupled electron transport 54 25 0.0000000
GO:0042775 mitochondrial ATP synthesis coupled electron transport 54 25 0.0000000
GO:0044281 small molecule metabolic process 2955 423 0.0000000
GO:0006119 oxidative phosphorylation 70 28 0.0000001
GO:0006120 mitochondrial electron transport, NADH to ubiquinone 42 20 0.0000006
GO:0015992 proton transport 112 35 0.0000010
GO:0015985 energy coupled proton transport, down electrochemical gradient 19 13 0.0000015
GO:0015986 ATP synthesis coupled proton transport 19 13 0.0000015
GO:0006818 hydrogen transport 114 35 0.0000015
GO:0042776 mitochondrial ATP synthesis coupled proton transport 14 10 0.0000771
GO:0006164 purine nucleotide biosynthetic process 191 45 0.0001928
GO:0046390 ribose phosphate biosynthetic process 201 46 0.0002973
GO:0009165 nucleotide biosynthetic process 259 55 0.0003455

traits/peer_k00_ratio_apob_apoa1_all_genes.txt

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Number of significant GO categories: 394

Number of DE genes: 2000

category term numInCat numDEInCat q.value
GO:0006955 immune response 1137 257 0
GO:0002376 immune system process 1936 361 0
GO:0045321 leukocyte activation 561 152 0
GO:0001775 cell activation 767 185 0
GO:0046649 lymphocyte activation 480 132 0
GO:0042110 T cell activation 347 100 0
GO:0002682 regulation of immune system process 997 201 0
GO:0006952 defense response 1178 225 0
GO:0050896 response to stimulus 6126 817 0
GO:0050776 regulation of immune response 666 148 0
GO:0045087 innate immune response 724 156 0
GO:0007165 signal transduction 4077 579 0
GO:0002684 positive regulation of immune system process 610 133 0
GO:0023052 signaling 4496 619 0
GO:0044700 single organism signaling 4496 619 0
GO:0002252 immune effector process 504 115 0
GO:0007154 cell communication 4559 623 0
GO:0002694 regulation of leukocyte activation 340 87 0
GO:0050865 regulation of cell activation 366 91 0
GO:0002757 immune response-activating signal transduction 333 86 0

traits/peer_k00_S_Ca_30_all_genes.txt

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Number of significant GO categories: 49

Number of DE genes: 2000

category term numInCat numDEInCat q.value
GO:0044699 single-organism process 10471 1517 0.0000000
GO:0044763 single-organism cellular process 9511 1393 0.0000001
GO:0006950 response to stress 2909 479 0.0000020
GO:0050896 response to stimulus 6126 934 0.0000020
GO:0065008 regulation of biological quality 2575 440 0.0000034
GO:0032501 multicellular organismal process 4965 779 0.0000070
GO:0048518 positive regulation of biological process 3684 589 0.0000406
GO:0044707 single-multicellular organism process 4822 750 0.0000741
GO:0009987 cellular process 11762 1634 0.0003600
GO:0048522 positive regulation of cellular process 3307 527 0.0003694
GO:0008150 biological_process 13154 1786 0.0009625
GO:0044710 single-organism metabolic process 4810 735 0.0009888
GO:0051704 multi-organism process 1681 272 0.0062651
GO:0023052 signaling 4496 693 0.0081024
GO:0044700 single organism signaling 4496 693 0.0081024
GO:0007154 cell communication 4559 700 0.0106878
GO:0042592 homeostatic process 1088 190 0.0117244
GO:0042060 wound healing 595 118 0.0122160
GO:0051641 cellular localization 2267 367 0.0143051
GO:0051716 cellular response to stimulus 4976 748 0.0165833

traits/peer_k00_total_daily_physical_activity_all_genes.txt

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Number of significant GO categories: 52

Number of DE genes: 2000

category term numInCat numDEInCat q.value
GO:0031326 regulation of cellular biosynthetic process 3340 440 0.0e+00
GO:0051252 regulation of RNA metabolic process 2966 399 0.0e+00
GO:0009889 regulation of biosynthetic process 3367 442 0.0e+00
GO:2001141 regulation of RNA biosynthetic process 2888 387 0.0e+00
GO:0016070 RNA metabolic process 3693 473 0.0e+00
GO:0006355 regulation of transcription, DNA-templated 2851 382 0.0e+00
GO:0010556 regulation of macromolecule biosynthetic process 3214 421 0.0e+00
GO:2000112 regulation of cellular macromolecule biosynthetic process 3129 411 0.0e+00
GO:0051171 regulation of nitrogen compound metabolic process 3754 479 0.0e+00
GO:0019219 regulation of nucleobase-containing compound metabolic process 3668 469 1.0e-07
GO:0090304 nucleic acid metabolic process 4166 518 1.0e-07
GO:0010468 regulation of gene expression 3465 444 1.0e-07
GO:0006351 transcription, DNA-templated 2952 388 1.0e-07
GO:0032774 RNA biosynthetic process 3063 396 3.0e-07
GO:0034641 cellular nitrogen compound metabolic process 5755 674 1.0e-06
GO:0031323 regulation of cellular metabolic process 4749 572 1.3e-06
GO:0019222 regulation of metabolic process 5252 621 2.8e-06
GO:0060255 regulation of macromolecule metabolic process 4402 532 2.8e-06
GO:0080090 regulation of primary metabolic process 4733 567 3.3e-06
GO:0044271 cellular nitrogen compound biosynthetic process 3463 430 4.5e-06

traits/peer_k01_fS_Trigly_all_genes.txt

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Number of significant GO categories: 166

Number of DE genes: 2000

category term numInCat numDEInCat q.value
GO:0006413 translational initiation 167 52 0.00e+00
GO:0072599 establishment of protein localization to endoplasmic reticulum 111 38 1.00e-07
GO:0006614 SRP-dependent cotranslational protein targeting to membrane 107 37 1.00e-07
GO:0001775 cell activation 767 144 1.00e-07
GO:0006613 cotranslational protein targeting to membrane 109 37 1.00e-07
GO:0045047 protein targeting to ER 110 37 1.00e-07
GO:0070972 protein localization to endoplasmic reticulum 128 40 3.00e-07
GO:0045321 leukocyte activation 561 111 3.00e-07
GO:0006415 translational termination 95 33 3.00e-07
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay 118 37 1.20e-06
GO:0002682 regulation of immune system process 997 169 1.80e-06
GO:0055114 oxidation-reduction process 896 154 2.30e-06
GO:0046649 lymphocyte activation 480 95 3.90e-06
GO:0006414 translational elongation 121 36 6.40e-06
GO:0042110 T cell activation 347 74 6.60e-06
GO:0002764 immune response-regulating signaling pathway 428 87 7.00e-06
GO:0019083 viral transcription 158 42 1.17e-05
GO:0002757 immune response-activating signal transduction 333 71 1.86e-05
GO:0006612 protein targeting to membrane 171 44 2.02e-05
GO:0002684 positive regulation of immune system process 610 110 2.78e-05

traits/peer_k01_GL120_all_genes.txt

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Number of significant GO categories: 2

Number of DE genes: 2000

category term numInCat numDEInCat q.value
GO:0044267 cellular protein metabolic process 3491 470 0.0004896
GO:0019538 protein metabolic process 4128 534 0.0071466
GO:0032268 regulation of cellular protein metabolic process 1414 205 0.0513434
GO:0048522 positive regulation of cellular process 3307 430 0.0585443
GO:0048518 positive regulation of biological process 3684 472 0.0692591

traits/peer_k01_GL60_all_genes.txt

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Number of significant GO categories: 26

Number of DE genes: 2000

category term numInCat numDEInCat q.value
GO:0045333 cellular respiration 158 59 0.0000000
GO:0022904 respiratory electron transport chain 105 41 0.0000000
GO:0006091 generation of precursor metabolites and energy 394 96 0.0000000
GO:0022900 electron transport chain 106 41 0.0000000
GO:0015980 energy derivation by oxidation of organic compounds 319 82 0.0000000
GO:0055114 oxidation-reduction process 896 160 0.0000000
GO:1902600 hydrogen ion transmembrane transport 84 27 0.0000363
GO:0015672 monovalent inorganic cation transport 350 70 0.0001980
GO:0015985 energy coupled proton transport, down electrochemical gradient 19 11 0.0003321
GO:0015986 ATP synthesis coupled proton transport 19 11 0.0003321
GO:0006818 hydrogen transport 114 30 0.0008033
GO:0042776 mitochondrial ATP synthesis coupled proton transport 14 9 0.0013596
GO:0015992 proton transport 112 29 0.0014277
GO:0042773 ATP synthesis coupled electron transport 54 18 0.0016517
GO:0042775 mitochondrial ATP synthesis coupled electron transport 54 18 0.0016517
GO:0006119 oxidative phosphorylation 70 21 0.0018695
GO:0006120 mitochondrial electron transport, NADH to ubiquinone 42 15 0.0034139
GO:0044281 small molecule metabolic process 2955 389 0.0074891
GO:0048514 blood vessel morphogenesis 421 75 0.0093370
GO:0006521 regulation of cellular amino acid metabolic process 59 18 0.0140732

traits/peer_k01_S_ALAT_all_genes.txt

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Number of significant GO categories: 10

Number of DE genes: 2000

category term numInCat numDEInCat q.value
GO:0003008 system process 1111 165 0.0032349
GO:0006936 muscle contraction 253 51 0.0122012
GO:0001508 action potential 144 34 0.0224464
GO:0035637 multicellular organismal signaling 141 33 0.0224464
GO:0008015 blood circulation 332 60 0.0224464
GO:0003013 circulatory system process 334 60 0.0224464
GO:0044057 regulation of system process 312 57 0.0224464
GO:0003012 muscle system process 299 55 0.0224464
GO:2001257 regulation of cation channel activity 55 17 0.0451309
GO:0043269 regulation of ion transport 403 68 0.0460520

traits/peer_k01_S_hs_CRP_all_genes.txt

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Number of significant GO categories: 64

Number of DE genes: 2000

category term numInCat numDEInCat q.value
GO:0023052 signaling 4496 575 0.0000755
GO:0044700 single organism signaling 4496 575 0.0000755
GO:0007154 cell communication 4559 579 0.0001214
GO:0035556 intracellular signal transduction 1995 281 0.0002879
GO:0019752 carboxylic acid metabolic process 829 131 0.0017467
GO:0044093 positive regulation of molecular function 1425 208 0.0017467
GO:0043085 positive regulation of catalytic activity 1225 183 0.0017467
GO:0000303 response to superoxide 20 11 0.0017467
GO:0000305 response to oxygen radical 21 11 0.0030851
GO:0050790 regulation of catalytic activity 1815 253 0.0031718
GO:0010243 response to organonitrogen compound 598 100 0.0031718
GO:0007165 signal transduction 4077 511 0.0051105
GO:0050896 response to stimulus 6126 733 0.0053690
GO:0045765 regulation of angiogenesis 158 36 0.0053690
GO:1901342 regulation of vasculature development 172 38 0.0062989
GO:0034599 cellular response to oxidative stress 159 36 0.0064609
GO:0055114 oxidation-reduction process 896 134 0.0064609
GO:0001525 angiogenesis 350 64 0.0070412
GO:0006082 organic acid metabolic process 944 141 0.0070412
GO:1901700 response to oxygen-containing compound 1037 152 0.0070412

traits/peer_k01_strenuous_physical_activity_all_genes.txt

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Number of significant GO categories: 0

Number of DE genes: 2000

category term numInCat numDEInCat q.value
GO:0048483 autonomic nervous system development 33 12 0.6623969
GO:0019752 carboxylic acid metabolic process 829 124 0.6623969
GO:0044237 cellular metabolic process 8652 1020 0.6623969
GO:0043436 oxoacid metabolic process 934 137 0.6623969
GO:0044238 primary metabolic process 8725 1027 0.6623969

traits/peer_k01_S_Uraat_all_genes.txt

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Number of significant GO categories: 1

Number of DE genes: 2000

category term numInCat numDEInCat q.value
GO:0055114 oxidation-reduction process 896 146 0.0001275
GO:0006091 generation of precursor metabolites and energy 394 69 0.0573155
GO:0015980 energy derivation by oxidation of organic compounds 319 58 0.0617869
GO:0030595 leukocyte chemotaxis 130 29 0.0909402
GO:0060326 cell chemotaxis 177 36 0.0909402

traits/peer_k01_WHR_all_genes.txt

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Number of significant GO categories: 0

Number of DE genes: 2000

category term numInCat numDEInCat q.value
GO:0055114 oxidation-reduction process 896 136 0.1322178
GO:0009888 tissue development 1345 193 0.2443891
GO:1901342 regulation of vasculature development 172 36 0.2743645
GO:0045765 regulation of angiogenesis 158 33 0.3358450
GO:0015980 energy derivation by oxidation of organic compounds 319 55 0.3358450

traits/peer_k03_bmi_all_genes.txt

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Number of significant GO categories: 105

Number of DE genes: 2000

category term numInCat numDEInCat q.value
GO:0006415 translational termination 95 62 0
GO:0006613 cotranslational protein targeting to membrane 109 66 0
GO:0045047 protein targeting to ER 110 66 0
GO:0006614 SRP-dependent cotranslational protein targeting to membrane 107 65 0
GO:0072599 establishment of protein localization to endoplasmic reticulum 111 66 0
GO:0006414 translational elongation 121 69 0
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay 118 68 0
GO:0070972 protein localization to endoplasmic reticulum 128 70 0
GO:0006413 translational initiation 167 80 0
GO:0006612 protein targeting to membrane 171 77 0
GO:0043624 cellular protein complex disassembly 174 75 0
GO:0043241 protein complex disassembly 195 79 0
GO:0000956 nuclear-transcribed mRNA catabolic process 184 76 0
GO:0032984 macromolecular complex disassembly 205 80 0
GO:0019083 viral transcription 158 67 0
GO:0006402 mRNA catabolic process 196 77 0
GO:0006412 translation 496 135 0
GO:0019080 viral gene expression 168 68 0
GO:0090150 establishment of protein localization to membrane 296 96 0
GO:0044033 multi-organism metabolic process 178 68 0

traits/peer_k03_fS_C_pept_30_all_genes.txt

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Number of significant GO categories: 48

Number of DE genes: 2000

category term numInCat numDEInCat q.value
GO:0006415 translational termination 95 47 0
GO:0006414 translational elongation 121 52 0
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay 118 51 0
GO:0006614 SRP-dependent cotranslational protein targeting to membrane 107 47 0
GO:0006413 translational initiation 167 61 0
GO:0006613 cotranslational protein targeting to membrane 109 47 0
GO:0045047 protein targeting to ER 110 47 0
GO:0019083 viral transcription 158 58 0
GO:0072599 establishment of protein localization to endoplasmic reticulum 111 47 0
GO:0070972 protein localization to endoplasmic reticulum 128 50 0
GO:0019080 viral gene expression 168 58 0
GO:0044033 multi-organism metabolic process 178 58 0
GO:0006612 protein targeting to membrane 171 56 0
GO:0043241 protein complex disassembly 195 60 0
GO:0043624 cellular protein complex disassembly 174 55 0
GO:0032984 macromolecular complex disassembly 205 60 0
GO:0000956 nuclear-transcribed mRNA catabolic process 184 56 0
GO:0006402 mRNA catabolic process 196 58 0
GO:0072657 protein localization to membrane 371 86 0
GO:0006401 RNA catabolic process 222 60 0

traits/peer_k03_fS_C_pept_all_genes.txt

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Number of significant GO categories: 76

Number of DE genes: 2000

category term numInCat numDEInCat q.value
GO:0006414 translational elongation 121 75 0
GO:0006415 translational termination 95 64 0
GO:0006613 cotranslational protein targeting to membrane 109 65 0
GO:0045047 protein targeting to ER 110 65 0
GO:0006614 SRP-dependent cotranslational protein targeting to membrane 107 64 0
GO:0072599 establishment of protein localization to endoplasmic reticulum 111 65 0
GO:0006413 translational initiation 167 81 0
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay 118 67 0
GO:0070972 protein localization to endoplasmic reticulum 128 68 0
GO:0043624 cellular protein complex disassembly 174 76 0
GO:0019083 viral transcription 158 71 0
GO:0006612 protein targeting to membrane 171 74 0
GO:0019080 viral gene expression 168 72 0
GO:0043241 protein complex disassembly 195 79 0
GO:0044033 multi-organism metabolic process 178 72 0
GO:0032984 macromolecular complex disassembly 205 79 0
GO:0000956 nuclear-transcribed mRNA catabolic process 184 72 0
GO:0006402 mRNA catabolic process 196 73 0
GO:0006401 RNA catabolic process 222 75 0
GO:0090150 establishment of protein localization to membrane 296 89 0

traits/peer_k03_fS_Kol_HDL_all_genes.txt

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Number of significant GO categories: 51

Number of DE genes: 2000

category term numInCat numDEInCat q.value
GO:0006414 translational elongation 121 47 0.00e+00
GO:0006415 translational termination 95 40 0.00e+00
GO:0006614 SRP-dependent cotranslational protein targeting to membrane 107 42 0.00e+00
GO:0006413 translational initiation 167 55 0.00e+00
GO:0006613 cotranslational protein targeting to membrane 109 42 0.00e+00
GO:0045047 protein targeting to ER 110 42 0.00e+00
GO:0072599 establishment of protein localization to endoplasmic reticulum 111 42 0.00e+00
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay 118 44 0.00e+00
GO:0070972 protein localization to endoplasmic reticulum 128 45 0.00e+00
GO:0006612 protein targeting to membrane 171 50 0.00e+00
GO:0043624 cellular protein complex disassembly 174 50 0.00e+00
GO:0043241 protein complex disassembly 195 53 1.00e-07
GO:0019083 viral transcription 158 45 1.00e-07
GO:0032984 macromolecular complex disassembly 205 53 4.00e-07
GO:0006412 translation 496 98 5.00e-07
GO:0019080 viral gene expression 168 45 1.20e-06
GO:0000956 nuclear-transcribed mRNA catabolic process 184 48 2.10e-06
GO:0044033 multi-organism metabolic process 178 46 2.70e-06
GO:0006402 mRNA catabolic process 196 49 7.10e-06
GO:0090150 establishment of protein localization to membrane 296 64 1.22e-05

traits/peer_k03_GL0_all_genes.txt

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Number of significant GO categories: 37

Number of DE genes: 2000

category term numInCat numDEInCat q.value
GO:0006613 cotranslational protein targeting to membrane 109 36 0.0000002
GO:0045047 protein targeting to ER 110 36 0.0000002
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay 118 38 0.0000002
GO:0072599 establishment of protein localization to endoplasmic reticulum 111 36 0.0000002
GO:0006614 SRP-dependent cotranslational protein targeting to membrane 107 35 0.0000002
GO:0006413 translational initiation 167 46 0.0000006
GO:0070972 protein localization to endoplasmic reticulum 128 38 0.0000012
GO:0006415 translational termination 95 31 0.0000020
GO:0006612 protein targeting to membrane 171 45 0.0000043
GO:0006414 translational elongation 121 34 0.0000352
GO:0000956 nuclear-transcribed mRNA catabolic process 184 44 0.0001410
GO:0006402 mRNA catabolic process 196 46 0.0001410
GO:0043624 cellular protein complex disassembly 174 42 0.0001663
GO:0043241 protein complex disassembly 195 45 0.0002378
GO:0006401 RNA catabolic process 222 48 0.0007006
GO:0032984 macromolecular complex disassembly 205 45 0.0008870
GO:0006412 translation 496 86 0.0012065
GO:0019083 viral transcription 158 36 0.0021543
GO:0019080 viral gene expression 168 37 0.0037171
GO:0090150 establishment of protein localization to membrane 296 56 0.0065217

traits/peer_k03_S_Ca_all_genes.txt

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Number of significant GO categories: 0

Number of DE genes: 2000

category term numInCat numDEInCat q.value
GO:0071482 cellular response to light stimulus 74 18 1
GO:0070245 positive regulation of thymocyte apoptotic process 6 4 1
GO:0008585 female gonad development 77 17 1
GO:0034644 cellular response to UV 47 12 1
GO:0046660 female sex differentiation 92 19 1

traits/peer_k03_S_Insu_30_all_genes.txt

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Number of significant GO categories: 55

Number of DE genes: 2000

category term numInCat numDEInCat q.value
GO:0006415 translational termination 95 44 0e+00
GO:0006414 translational elongation 121 49 0e+00
GO:0006614 SRP-dependent cotranslational protein targeting to membrane 107 45 0e+00
GO:0006613 cotranslational protein targeting to membrane 109 45 0e+00
GO:0045047 protein targeting to ER 110 45 0e+00
GO:0072599 establishment of protein localization to endoplasmic reticulum 111 45 0e+00
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay 118 47 0e+00
GO:0070972 protein localization to endoplasmic reticulum 128 48 0e+00
GO:0019083 viral transcription 158 54 0e+00
GO:0006413 translational initiation 167 56 0e+00
GO:0019080 viral gene expression 168 54 0e+00
GO:0044033 multi-organism metabolic process 178 54 0e+00
GO:0043624 cellular protein complex disassembly 174 53 0e+00
GO:0043241 protein complex disassembly 195 57 0e+00
GO:0006612 protein targeting to membrane 171 52 0e+00
GO:0000956 nuclear-transcribed mRNA catabolic process 184 54 0e+00
GO:0006402 mRNA catabolic process 196 56 0e+00
GO:0032984 macromolecular complex disassembly 205 57 0e+00
GO:0006401 RNA catabolic process 222 59 0e+00
GO:0072657 protein localization to membrane 371 81 7e-07

traits/peer_k03_S_Insu_all_genes.txt

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Number of significant GO categories: 104

Number of DE genes: 2000

category term numInCat numDEInCat q.value
GO:0006415 translational termination 95 64 0
GO:0006414 translational elongation 121 72 0
GO:0006613 cotranslational protein targeting to membrane 109 64 0
GO:0045047 protein targeting to ER 110 64 0
GO:0006614 SRP-dependent cotranslational protein targeting to membrane 107 63 0
GO:0072599 establishment of protein localization to endoplasmic reticulum 111 64 0
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay 118 66 0
GO:0006413 translational initiation 167 79 0
GO:0070972 protein localization to endoplasmic reticulum 128 68 0
GO:0043624 cellular protein complex disassembly 174 77 0
GO:0043241 protein complex disassembly 195 80 0
GO:0006612 protein targeting to membrane 171 74 0
GO:0019083 viral transcription 158 69 0
GO:0032984 macromolecular complex disassembly 205 80 0
GO:0019080 viral gene expression 168 69 0
GO:0044033 multi-organism metabolic process 178 69 0
GO:0000956 nuclear-transcribed mRNA catabolic process 184 70 0
GO:0090150 establishment of protein localization to membrane 296 93 0
GO:0006402 mRNA catabolic process 196 71 0
GO:0072657 protein localization to membrane 371 106 0

traits/peer_k03_S_LipoA1_all_genes.txt

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Number of significant GO categories: 0

Number of DE genes: 2000

category term numInCat numDEInCat q.value
GO:0006091 generation of precursor metabolites and energy 394 68 0.5224548
GO:0070544 histone H3-K36 demethylation 6 5 1.0000000
GO:0006096 glycolytic process 57 16 1.0000000
GO:0016570 histone modification 343 60 1.0000000
GO:0044724 single-organism carbohydrate catabolic process 124 26 1.0000000

traits/peer_k04_B_GHb_A1C_all_genes.txt

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Number of significant GO categories: 8

Number of DE genes: 2000

category term numInCat numDEInCat q.value
GO:0006405 RNA export from nucleus 80 24 0.0080446
GO:0015931 nucleobase-containing compound transport 169 39 0.0080446
GO:0050657 nucleic acid transport 144 35 0.0080446
GO:0050658 RNA transport 144 35 0.0080446
GO:0051236 establishment of RNA localization 144 35 0.0080446
GO:0006403 RNA localization 151 36 0.0080446
GO:0090304 nucleic acid metabolic process 4166 501 0.0332188
GO:0051168 nuclear export 136 31 0.0474482

traits/peer_k04_daily_energy_expenditure_all_genes.txt

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Number of significant GO categories: 0

Number of DE genes: 2000

category term numInCat numDEInCat q.value
GO:0010629 negative regulation of gene expression 916 142 0.3644036
GO:0006974 cellular response to DNA damage stimulus 668 106 0.3644036
GO:0016570 histone modification 343 64 0.3644036
GO:0006325 chromatin organization 563 94 0.3644036
GO:0018205 peptidyl-lysine modification 181 38 0.3644036

traits/peer_k06_S_GT_all_genes.txt

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Number of significant GO categories: 0

Number of DE genes: 2000

category term numInCat numDEInCat q.value
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity 80 19 1
GO:0003163 sinoatrial node development 5 4 1
GO:0060931 sinoatrial node cell development 3 3 1
GO:0001977 renal system process involved in regulation of blood volume 14 6 1
GO:0071157 negative regulation of cell cycle arrest 14 6 1

traits/peer_k06_S_LipoB_all_genes.txt

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Number of significant GO categories: 2

Number of DE genes: 2000

category term numInCat numDEInCat q.value
GO:0070613 regulation of protein processing 180 37 0.0266967
GO:1903317 regulation of protein maturation 180 37 0.0266967
GO:0032956 regulation of actin cytoskeleton organization 216 41 0.0659542
GO:0032970 regulation of actin filament-based process 258 46 0.0831644
GO:0051604 protein maturation 356 57 0.1088035

traits/peer_k07_SBP_all_genes.txt

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Number of significant GO categories: 0

Number of DE genes: 2000

category term numInCat numDEInCat q.value
GO:0006695 cholesterol biosynthetic process 42 13 1
GO:0016126 sterol biosynthetic process 47 13 1
GO:0009755 hormone-mediated signaling pathway 73 18 1
GO:0030518 intracellular steroid hormone receptor signaling pathway 104 23 1
GO:0006357 regulation of transcription from RNA polymerase II promoter 1305 171 1

ngt_vs_t2d/peer_k03_all_genes.txt

plot of chunk unnamed-chunk-100

Number of significant GO categories: 23

Number of DE genes: 2000

category term numInCat numDEInCat q.value
GO:0022904 respiratory electron transport chain 105 47 0.0000000
GO:0022900 electron transport chain 106 47 0.0000000
GO:0045333 cellular respiration 158 55 0.0000000
GO:1902600 hydrogen ion transmembrane transport 84 32 0.0000000
GO:0015980 energy derivation by oxidation of organic compounds 319 75 0.0000000
GO:0006091 generation of precursor metabolites and energy 395 86 0.0000000
GO:0055114 oxidation-reduction process 895 154 0.0000002
GO:0015992 proton transport 112 34 0.0000024
GO:0006818 hydrogen transport 114 34 0.0000038
GO:0042773 ATP synthesis coupled electron transport 54 21 0.0000099
GO:0042775 mitochondrial ATP synthesis coupled electron transport 54 21 0.0000099
GO:0015985 energy coupled proton transport, down electrochemical gradient 19 12 0.0000126
GO:0015986 ATP synthesis coupled proton transport 19 12 0.0000126
GO:0006119 oxidative phosphorylation 70 23 0.0000786
GO:0006120 mitochondrial electron transport, NADH to ubiquinone 42 16 0.0005121
GO:0006754 ATP biosynthetic process 36 15 0.0006086
GO:0042776 mitochondrial ATP synthesis coupled proton transport 14 9 0.0006173
GO:0009127 purine nucleoside monophosphate biosynthetic process 61 19 0.0042433
GO:0009168 purine ribonucleoside monophosphate biosynthetic process 61 19 0.0042433
GO:0009145 purine nucleoside triphosphate biosynthetic process 47 16 0.0049082