This is an initial analysis of GO term enrichment for DE results from all traits that we analyzed.

For this report we called the top 300 genes as differentially expressed. We display at minimum 5 categories for each trait, and at most 20, ordered by significance.

This report was last generated on Tue May 12 10:34:41 PM 2015

age/peer_k00_age_biopsy_all_genes.txt

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Number of significant GO categories: 15

Number of DE genes: 300

category term numInCat numDEInCat q.value
GO:0090304 nucleic acid metabolic process 4166 116 0.0001307
GO:0006139 nucleobase-containing compound metabolic process 5435 138 0.0005018
GO:0016070 RNA metabolic process 3693 102 0.0009050
GO:0046483 heterocycle metabolic process 5565 138 0.0009050
GO:0006725 cellular aromatic compound metabolic process 5569 138 0.0009050
GO:0034641 cellular nitrogen compound metabolic process 5755 141 0.0009492
GO:1901360 organic cyclic compound metabolic process 5728 139 0.0019512
GO:0010467 gene expression 4322 111 0.0043714
GO:0006807 nitrogen compound metabolic process 6075 143 0.0118963
GO:0010556 regulation of macromolecule biosynthetic process 3214 87 0.0278814
GO:2000112 regulation of cellular macromolecule biosynthetic process 3129 85 0.0318805
GO:0031326 regulation of cellular biosynthetic process 3340 89 0.0318805
GO:0006351 transcription, DNA-templated 2952 81 0.0318805
GO:0009889 regulation of biosynthetic process 3367 89 0.0369056
GO:0032774 RNA biosynthetic process 3063 82 0.0464189

sex/peer_k00_sex_all_genes.txt

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Number of significant GO categories: 0

Number of DE genes: 300

category term numInCat numDEInCat q.value
GO:0016577 histone demethylation 22 5 0.2983971
GO:0006482 protein demethylation 24 5 0.2983971
GO:0008214 protein dealkylation 24 5 0.2983971
GO:0003002 regionalization 261 14 0.4944897
GO:0090304 nucleic acid metabolic process 4166 93 0.8234373

smoking/peer_k01_smoking_all_genes.txt

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Number of significant GO categories: 0

Number of DE genes: 300

category term numInCat numDEInCat q.value
GO:0006532 aspartate biosynthetic process 2 2 0.6899004
GO:0019550 glutamate catabolic process to aspartate 2 2 0.6899004
GO:0019551 glutamate catabolic process to 2-oxoglutarate 2 2 0.6899004
GO:0006106 fumarate metabolic process 3 2 1.0000000
GO:0006533 aspartate catabolic process 4 2 1.0000000

traits/peer_k00_DBP_all_genes.txt

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Number of significant GO categories: 89

Number of DE genes: 300

category term numInCat numDEInCat q.value
GO:0045333 cellular respiration 158 44 0
GO:0006091 generation of precursor metabolites and energy 394 49 0
GO:0015980 energy derivation by oxidation of organic compounds 319 45 0
GO:0022904 respiratory electron transport chain 105 32 0
GO:0022900 electron transport chain 106 32 0
GO:0055114 oxidation-reduction process 896 65 0
GO:0006119 oxidative phosphorylation 70 20 0
GO:0009060 aerobic respiration 46 16 0
GO:0042773 ATP synthesis coupled electron transport 54 18 0
GO:0042775 mitochondrial ATP synthesis coupled electron transport 54 18 0
GO:0044281 small molecule metabolic process 2955 96 0
GO:0006120 mitochondrial electron transport, NADH to ubiquinone 42 16 0
GO:0046034 ATP metabolic process 442 31 0
GO:0006099 tricarboxylic acid cycle 28 12 0
GO:0009161 ribonucleoside monophosphate metabolic process 478 32 0
GO:0009167 purine ribonucleoside monophosphate metabolic process 466 31 0
GO:0009126 purine nucleoside monophosphate metabolic process 467 31 0
GO:0009123 nucleoside monophosphate metabolic process 489 32 0
GO:0044710 single-organism metabolic process 4810 118 0
GO:1902600 hydrogen ion transmembrane transport 84 16 0

traits/peer_k00_fS_Kol_all_genes.txt

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Number of significant GO categories: 0

Number of DE genes: 300

category term numInCat numDEInCat q.value
GO:0033169 histone H3-K9 demethylation 7 3 0.8767483
GO:1902001 fatty acid transmembrane transport 16 4 0.8767483
GO:0061187 regulation of chromatin silencing at rDNA 2 2 0.8767483
GO:0061188 negative regulation of chromatin silencing at rDNA 2 2 0.8767483
GO:0015908 fatty acid transport 61 6 0.8767483

traits/peer_k00_fS_Kol_LDL_c_all_genes.txt

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Number of significant GO categories: 0

Number of DE genes: 300

category term numInCat numDEInCat q.value
GO:0044255 cellular lipid metabolic process 772 27 0.7828654
GO:0006629 lipid metabolic process 1015 31 0.7828654
GO:1902001 fatty acid transmembrane transport 16 4 0.7828654
GO:0006066 alcohol metabolic process 315 14 0.7828654
GO:0061187 regulation of chromatin silencing at rDNA 2 2 0.7828654

traits/peer_k00_fS_Krea_all_genes.txt

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Number of significant GO categories: 0

Number of DE genes: 300

category term numInCat numDEInCat q.value
GO:0016070 RNA metabolic process 3693 86 0.0573541
GO:0090304 nucleic acid metabolic process 4166 94 0.0573541
GO:0010467 gene expression 4322 94 0.1528345
GO:0000375 RNA splicing, via transesterification reactions 225 13 0.1528345
GO:0042254 ribosome biogenesis 167 11 0.1563725

traits/peer_k00_GL30_all_genes.txt

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Number of significant GO categories: 8

Number of DE genes: 300

category term numInCat numDEInCat q.value
GO:0022904 respiratory electron transport chain 105 12 0.0008872
GO:0022900 electron transport chain 106 12 0.0008872
GO:0006119 oxidative phosphorylation 70 10 0.0008872
GO:1902600 hydrogen ion transmembrane transport 84 9 0.0318276
GO:0045333 cellular respiration 158 12 0.0402547
GO:0006091 generation of precursor metabolites and energy 394 20 0.0416677
GO:0042773 ATP synthesis coupled electron transport 54 7 0.0416677
GO:0042775 mitochondrial ATP synthesis coupled electron transport 54 7 0.0416677

traits/peer_k00_ratio_apob_apoa1_all_genes.txt

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Number of significant GO categories: 60

Number of DE genes: 300

category term numInCat numDEInCat q.value
GO:0045321 leukocyte activation 561 31 0.0000122
GO:0002376 immune system process 1936 64 0.0000137
GO:0002682 regulation of immune system process 997 42 0.0000137
GO:0001775 cell activation 767 35 0.0000429
GO:0042110 T cell activation 347 21 0.0003808
GO:0046649 lymphocyte activation 480 25 0.0003808
GO:0050776 regulation of immune response 666 30 0.0004478
GO:0050865 regulation of cell activation 366 21 0.0004478
GO:0023052 signaling 4496 107 0.0004478
GO:0044700 single organism signaling 4496 107 0.0004478
GO:0050896 response to stimulus 6126 134 0.0004478
GO:0006955 immune response 1137 41 0.0004478
GO:0002694 regulation of leukocyte activation 340 20 0.0004513
GO:0002429 immune response-activating cell surface receptor signaling pathway 204 15 0.0008970
GO:0002684 positive regulation of immune system process 610 27 0.0011816
GO:0002757 immune response-activating signal transduction 333 19 0.0014180
GO:0050851 antigen receptor-mediated signaling pathway 138 12 0.0014702
GO:0007154 cell communication 4559 106 0.0014702
GO:0050778 positive regulation of immune response 441 22 0.0014702
GO:0050863 regulation of T cell activation 226 15 0.0018827

traits/peer_k00_S_Ca_30_all_genes.txt

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Number of significant GO categories: 0

Number of DE genes: 300

category term numInCat numDEInCat q.value
GO:0031532 actin cytoskeleton reorganization 66 6 1
GO:0022409 positive regulation of cell-cell adhesion 31 4 1
GO:0051712 positive regulation of killing of cells of other organism 5 2 1
GO:0042744 hydrogen peroxide catabolic process 19 3 1
GO:0046847 filopodium assembly 54 5 1

traits/peer_k00_total_daily_physical_activity_all_genes.txt

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Number of significant GO categories: 0

Number of DE genes: 300

category term numInCat numDEInCat q.value
GO:0010556 regulation of macromolecule biosynthetic process 3214 76 0.2087178
GO:0090304 nucleic acid metabolic process 4166 92 0.2087178
GO:2001141 regulation of RNA biosynthetic process 2888 69 0.2087178
GO:0016070 RNA metabolic process 3693 83 0.2087178
GO:0006355 regulation of transcription, DNA-templated 2851 68 0.2087178

traits/peer_k01_fS_Trigly_all_genes.txt

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Number of significant GO categories: 0

Number of DE genes: 300

category term numInCat numDEInCat q.value
GO:0009063 cellular amino acid catabolic process 103 9 0.5176136
GO:0055114 oxidation-reduction process 896 31 0.5176136
GO:0019695 choline metabolic process 7 3 0.5176136
GO:0006614 SRP-dependent cotranslational protein targeting to membrane 107 8 0.5176136
GO:0006613 cotranslational protein targeting to membrane 109 8 0.5176136

traits/peer_k01_GL120_all_genes.txt

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Number of significant GO categories: 0

Number of DE genes: 300

category term numInCat numDEInCat q.value
GO:0006614 SRP-dependent cotranslational protein targeting to membrane 107 9 0.1855205
GO:0006613 cotranslational protein targeting to membrane 109 9 0.1855205
GO:0045047 protein targeting to ER 110 9 0.1855205
GO:0012501 programmed cell death 1539 47 0.1855205
GO:0072599 establishment of protein localization to endoplasmic reticulum 111 9 0.1855205

traits/peer_k01_GL60_all_genes.txt

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Number of significant GO categories: 0

Number of DE genes: 300

category term numInCat numDEInCat q.value
GO:0045765 regulation of angiogenesis 158 12 0.1619722
GO:0032879 regulation of localization 1622 52 0.1619722
GO:0002040 sprouting angiogenesis 53 7 0.1762912
GO:1901342 regulation of vasculature development 172 12 0.1762912
GO:0048102 autophagic cell death 6 3 0.1842694

traits/peer_k01_S_ALAT_all_genes.txt

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Number of significant GO categories: 0

Number of DE genes: 300

category term numInCat numDEInCat q.value
GO:0032370 positive regulation of lipid transport 34 6 0.244248
GO:0050653 chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process 2 2 1.000000
GO:0032368 regulation of lipid transport 63 6 1.000000
GO:0055080 cation homeostasis 423 16 1.000000
GO:0055065 metal ion homeostasis 388 15 1.000000

traits/peer_k01_S_hs_CRP_all_genes.txt

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Number of significant GO categories: 0

Number of DE genes: 300

category term numInCat numDEInCat q.value
GO:0048514 blood vessel morphogenesis 421 21 0.111255
GO:0044707 single-multicellular organism process 4822 115 0.111255
GO:0001525 angiogenesis 350 18 0.111255
GO:1901342 regulation of vasculature development 172 12 0.111255
GO:0032501 multicellular organismal process 4965 117 0.111255

traits/peer_k01_strenuous_physical_activity_all_genes.txt

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Number of significant GO categories: 0

Number of DE genes: 300

category term numInCat numDEInCat q.value
GO:0002317 plasma cell differentiation 2 2 1
GO:0006418 tRNA aminoacylation for protein translation 46 5 1
GO:0016126 sterol biosynthetic process 47 5 1
GO:0001836 release of cytochrome c from mitochondria 51 5 1
GO:0043038 amino acid activation 50 5 1

traits/peer_k01_S_Uraat_all_genes.txt

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Number of significant GO categories: 0

Number of DE genes: 300

category term numInCat numDEInCat q.value
GO:1901700 response to oxygen-containing compound 1037 33 1
GO:0007007 inner mitochondrial membrane organization 11 3 1
GO:0032898 neurotrophin production 4 2 1
GO:0009063 cellular amino acid catabolic process 103 7 1
GO:1901606 alpha-amino acid catabolic process 79 6 1

traits/peer_k01_WHR_all_genes.txt

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Number of significant GO categories: 0

Number of DE genes: 300

category term numInCat numDEInCat q.value
GO:0048630 skeletal muscle tissue growth 6 3 0.6202767
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway 646 26 0.6202767
GO:0044342 type B pancreatic cell proliferation 8 3 0.6202767
GO:0046886 positive regulation of hormone biosynthetic process 8 3 0.6202767
GO:1901653 cellular response to peptide 270 14 0.6202767

traits/peer_k03_bmi_all_genes.txt

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Number of significant GO categories: 89

Number of DE genes: 300

category term numInCat numDEInCat q.value
GO:0006415 translational termination 95 26 0
GO:0006413 translational initiation 167 31 0
GO:0070972 protein localization to endoplasmic reticulum 128 28 0
GO:0006614 SRP-dependent cotranslational protein targeting to membrane 107 26 0
GO:0006613 cotranslational protein targeting to membrane 109 26 0
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay 118 27 0
GO:0045047 protein targeting to ER 110 26 0
GO:0072599 establishment of protein localization to endoplasmic reticulum 111 26 0
GO:0006414 translational elongation 121 26 0
GO:0043624 cellular protein complex disassembly 174 28 0
GO:0000956 nuclear-transcribed mRNA catabolic process 184 28 0
GO:0006612 protein targeting to membrane 171 27 0
GO:0043241 protein complex disassembly 195 28 0
GO:0006402 mRNA catabolic process 196 28 0
GO:0019083 viral transcription 158 25 0
GO:0032984 macromolecular complex disassembly 205 28 0
GO:0006401 RNA catabolic process 222 29 0
GO:0019080 viral gene expression 168 25 0
GO:0006412 translation 496 41 0
GO:0044033 multi-organism metabolic process 178 25 0

traits/peer_k03_fS_C_pept_30_all_genes.txt

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Number of significant GO categories: 47

Number of DE genes: 300

category term numInCat numDEInCat q.value
GO:0006413 translational initiation 167 23 0.0000000
GO:0006415 translational termination 95 15 0.0000001
GO:0070972 protein localization to endoplasmic reticulum 128 17 0.0000001
GO:0006412 translation 496 33 0.0000001
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay 118 16 0.0000003
GO:0019083 viral transcription 158 18 0.0000003
GO:0006414 translational elongation 121 16 0.0000003
GO:0006614 SRP-dependent cotranslational protein targeting to membrane 107 15 0.0000003
GO:0006613 cotranslational protein targeting to membrane 109 15 0.0000003
GO:0045047 protein targeting to ER 110 15 0.0000003
GO:0072599 establishment of protein localization to endoplasmic reticulum 111 15 0.0000003
GO:0019080 viral gene expression 168 18 0.0000004
GO:0044033 multi-organism metabolic process 178 18 0.0000010
GO:0006612 protein targeting to membrane 171 16 0.0000337
GO:0043241 protein complex disassembly 195 17 0.0000442
GO:0043624 cellular protein complex disassembly 174 16 0.0000459
GO:0032984 macromolecular complex disassembly 205 17 0.0000802
GO:0000956 nuclear-transcribed mRNA catabolic process 184 16 0.0000909
GO:0006402 mRNA catabolic process 196 16 0.0002266
GO:0051186 cofactor metabolic process 249 18 0.0003095

traits/peer_k03_fS_C_pept_all_genes.txt

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Number of significant GO categories: 73

Number of DE genes: 300

category term numInCat numDEInCat q.value
GO:0006413 translational initiation 167 32 0
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay 118 28 0
GO:0006415 translational termination 95 25 0
GO:0006614 SRP-dependent cotranslational protein targeting to membrane 107 26 0
GO:0006613 cotranslational protein targeting to membrane 109 26 0
GO:0045047 protein targeting to ER 110 26 0
GO:0006414 translational elongation 121 27 0
GO:0072599 establishment of protein localization to endoplasmic reticulum 111 26 0
GO:0070972 protein localization to endoplasmic reticulum 128 27 0
GO:0006412 translation 496 46 0
GO:0000956 nuclear-transcribed mRNA catabolic process 184 28 0
GO:0006402 mRNA catabolic process 196 28 0
GO:0019083 viral transcription 158 25 0
GO:0006612 protein targeting to membrane 171 26 0
GO:0043624 cellular protein complex disassembly 174 26 0
GO:0019080 viral gene expression 168 25 0
GO:0044033 multi-organism metabolic process 178 25 0
GO:0006401 RNA catabolic process 222 28 0
GO:0043241 protein complex disassembly 195 26 0
GO:0032984 macromolecular complex disassembly 205 26 0

traits/peer_k03_fS_Kol_HDL_all_genes.txt

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Number of significant GO categories: 3

Number of DE genes: 300

category term numInCat numDEInCat q.value
GO:0006413 translational initiation 167 13 0.0157004
GO:0006412 translation 496 22 0.0451367
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay 118 10 0.0451367
GO:0043933 macromolecular complex subunit organization 1450 46 0.0791671
GO:0045821 positive regulation of glycolytic process 11 4 0.0812669

traits/peer_k03_GL0_all_genes.txt

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Number of significant GO categories: 1

Number of DE genes: 300

category term numInCat numDEInCat q.value
GO:0055091 phospholipid homeostasis 7 4 0.0387322
GO:0019395 fatty acid oxidation 77 8 0.3211151
GO:0034440 lipid oxidation 79 8 0.3211151
GO:0055081 anion homeostasis 27 5 0.3211151
GO:0006390 transcription from mitochondrial promoter 8 3 0.6032100

traits/peer_k03_S_Ca_all_genes.txt

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Number of significant GO categories: 0

Number of DE genes: 300

category term numInCat numDEInCat q.value
GO:0071810 regulation of fever generation by regulation of prostaglandin secretion 2 2 0.5969104
GO:0071812 positive regulation of fever generation by positive regulation of prostaglandin secretion 2 2 0.5969104
GO:0071847 TNFSF11-mediated signaling pathway 2 2 0.5969104
GO:0071848 positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling 2 2 0.5969104
GO:0008360 regulation of cell shape 105 8 0.5969104

traits/peer_k03_S_Insu_30_all_genes.txt

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Number of significant GO categories: 10

Number of DE genes: 300

category term numInCat numDEInCat q.value
GO:0006413 translational initiation 167 15 0.0020035
GO:0051186 cofactor metabolic process 249 18 0.0035766
GO:0006091 generation of precursor metabolites and energy 394 22 0.0068333
GO:0006732 coenzyme metabolic process 194 15 0.0068333
GO:0019752 carboxylic acid metabolic process 829 35 0.0068333
GO:0051188 cofactor biosynthetic process 132 12 0.0111515
GO:0006082 organic acid metabolic process 944 37 0.0145442
GO:0015980 energy derivation by oxidation of organic compounds 319 18 0.0205702
GO:0043436 oxoacid metabolic process 934 36 0.0217265
GO:0006412 translation 496 23 0.0258973

traits/peer_k03_S_Insu_all_genes.txt

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Number of significant GO categories: 61

Number of DE genes: 300

category term numInCat numDEInCat q.value
GO:0006614 SRP-dependent cotranslational protein targeting to membrane 107 24 0
GO:0006613 cotranslational protein targeting to membrane 109 24 0
GO:0045047 protein targeting to ER 110 24 0
GO:0072599 establishment of protein localization to endoplasmic reticulum 111 24 0
GO:0006413 translational initiation 167 28 0
GO:0070972 protein localization to endoplasmic reticulum 128 25 0
GO:0006415 translational termination 95 22 0
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay 118 24 0
GO:0006414 translational elongation 121 24 0
GO:0006412 translation 496 40 0
GO:0006612 protein targeting to membrane 171 24 0
GO:0000956 nuclear-transcribed mRNA catabolic process 184 24 0
GO:0019083 viral transcription 158 22 0
GO:0043624 cellular protein complex disassembly 174 23 0
GO:0006402 mRNA catabolic process 196 24 0
GO:0019080 viral gene expression 168 22 0
GO:0044033 multi-organism metabolic process 178 22 0
GO:0043241 protein complex disassembly 195 23 0
GO:0006401 RNA catabolic process 222 24 0
GO:0032984 macromolecular complex disassembly 205 23 0

traits/peer_k03_S_LipoA1_all_genes.txt

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Number of significant GO categories: 0

Number of DE genes: 300

category term numInCat numDEInCat q.value
GO:0006091 generation of precursor metabolites and energy 394 18 0.6523462
GO:0015980 energy derivation by oxidation of organic compounds 319 15 0.6523462
GO:2001268 negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway 2 2 0.6523462
GO:0051188 cofactor biosynthetic process 132 9 0.6523462
GO:0005977 glycogen metabolic process 78 7 0.6523462

traits/peer_k04_B_GHb_A1C_all_genes.txt

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Number of significant GO categories: 0

Number of DE genes: 300

category term numInCat numDEInCat q.value
GO:0050657 nucleic acid transport 144 10 0.8822068
GO:0050658 RNA transport 144 10 0.8822068
GO:0051236 establishment of RNA localization 144 10 0.8822068
GO:0043353 enucleate erythrocyte differentiation 8 3 0.8822068
GO:0006403 RNA localization 151 10 0.8822068

traits/peer_k04_daily_energy_expenditure_all_genes.txt

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Number of significant GO categories: 0

Number of DE genes: 300

category term numInCat numDEInCat q.value
GO:0016525 negative regulation of angiogenesis 55 5 1
GO:0046856 phosphatidylinositol dephosphorylation 17 3 1
GO:0003128 heart field specification 6 2 1
GO:0003139 secondary heart field specification 6 2 1
GO:0032330 regulation of chondrocyte differentiation 38 4 1

traits/peer_k06_S_GT_all_genes.txt

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Number of significant GO categories: 0

Number of DE genes: 300

category term numInCat numDEInCat q.value
GO:0051188 cofactor biosynthetic process 132 9 1
GO:0038083 peptidyl-tyrosine autophosphorylation 9 3 1
GO:0035634 response to stilbenoid 3 2 1
GO:0051186 cofactor metabolic process 249 12 1
GO:0033013 tetrapyrrole metabolic process 50 5 1

traits/peer_k06_S_LipoB_all_genes.txt

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Number of significant GO categories: 0

Number of DE genes: 300

category term numInCat numDEInCat q.value
GO:1902001 fatty acid transmembrane transport 16 4 0.9662187
GO:0006853 carnitine shuttle 9 3 0.9662187
GO:0006865 amino acid transport 119 8 0.9662187
GO:0015711 organic anion transport 293 13 0.9662187
GO:0010286 heat acclimation 3 2 0.9662187

traits/peer_k07_SBP_all_genes.txt

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Number of significant GO categories: 0

Number of DE genes: 300

category term numInCat numDEInCat q.value
GO:0032740 positive regulation of interleukin-17 production 7 3 1
GO:0032660 regulation of interleukin-17 production 14 3 1
GO:0001866 NK T cell proliferation 4 2 1
GO:0032620 interleukin-17 production 15 3 1
GO:0032819 positive regulation of natural killer cell proliferation 4 2 1

ngt_vs_t2d/peer_k03_all_genes.txt

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Number of significant GO categories: 3

Number of DE genes: 300

category term numInCat numDEInCat q.value
GO:0022904 respiratory electron transport chain 105 11 0.0027595
GO:0022900 electron transport chain 106 11 0.0027595
GO:0045333 cellular respiration 158 12 0.0237158
GO:0006120 mitochondrial electron transport, NADH to ubiquinone 42 6 0.0862372
GO:0042773 ATP synthesis coupled electron transport 54 6 0.2685357