| GO:0010565 |
1 |
GO:0010565 |
regulation of cellular ketone metabolic process |
GOBP |
130 |
-0.4803374 |
0.6185746 |
down |
0.0001725 |
0.0067321 |
37 5164 8473 5708 11315 5688 5706 83752 5693 9861 10213 5686 23417 5711 5629 5581 5682 |
| GO:0042180 |
1 |
GO:0042180 |
cellular ketone metabolic process |
GOBP |
173 |
-0.3967912 |
0.6724744 |
down |
0.0005515 |
0.0168585 |
37 5164 8473 5708 11315 5688 5706 83752 5693 9861 10213 51004 5686 23417 5711 5629 5581 5682 51166 2232 57016 |
| GO:0071156 |
2 |
GO:0071156 |
regulation of cell cycle arrest |
GOBP |
100 |
-0.7300510 |
0.4818844 |
down |
0.0000000 |
0.0000055 |
274 5708 5688 5706 5693 9861 10213 8812 5686 472 5371 5711 835 5682 1017 79366 |
| GO:0007050 |
2 |
GO:0007050 |
cell cycle arrest |
GOBP |
206 |
-0.5191471 |
0.5950278 |
down |
0.0000003 |
0.0000273 |
274 5708 5688 11180 7249 5706 53632 5693 9861 10213 323 8812 5686 472 5371 5711 835 1647 5682 1017 92335 79366 |
| GO:0090090 |
3 |
GO:0090090 |
negative regulation of canonical Wnt signaling pathway |
GOBP |
137 |
-0.6602521 |
0.5167210 |
down |
0.0000001 |
0.0000067 |
5708 5688 5706 1500 5693 9861 10213 5686 5711 4038 22881 5682 85409 |
| GO:0030178 |
3 |
GO:0030178 |
negative regulation of Wnt signaling pathway |
GOBP |
165 |
-0.4968677 |
0.6084335 |
down |
0.0000220 |
0.0011692 |
5708 5688 7249 5706 1500 5693 9861 10213 9968 5686 5711 10042 4038 22881 5682 129293 85409 |
| GO:0060828 |
3 |
GO:0060828 |
regulation of canonical Wnt signaling pathway |
GOBP |
201 |
-0.3687103 |
0.6916258 |
down |
0.0006982 |
0.0201431 |
5708 5688 5706 1500 5693 9861 10213 5686 65981 5711 4041 4038 83595 22881 5682 406 85409 |
| GO:0006261 |
4 |
GO:0006261 |
DNA-dependent DNA replication |
GOBP |
117 |
0.4234355 |
1.5271992 |
up |
0.0006838 |
0.0199642 |
8243 5426 79892 4176 5980 4172 9984 4171 5422 11177 84515 11232 10714 3978 4361 5985 253714 378708 |
| GO:0006310 |
4 |
GO:0006310 |
DNA recombination |
GOBP |
179 |
0.3458948 |
1.4132539 |
up |
0.0009765 |
0.0254907 |
10933 23049 5885 6830 5591 7528 9656 10213 5426 9730 23054 23503 3148 472 79677 9984 5422 23514 22976 10714 3978 4361 5985 254394 253714 10635 25788 378708 |
| GO:0019884 |
5 |
GO:0019884 |
antigen processing and presentation of exogenous antigen |
GOBP |
162 |
-0.6082922 |
0.5442796 |
down |
0.0000000 |
0.0000037 |
948 5708 114876 5688 1785 8905 1783 5706 5693 9861 10213 5686 5711 5682 |
| GO:0002478 |
5 |
GO:0002478 |
antigen processing and presentation of exogenous peptide antigen |
GOBP |
159 |
-0.5900243 |
0.5543138 |
down |
0.0000001 |
0.0000094 |
948 5708 114876 5688 1785 8905 1783 5706 5693 9861 10213 5686 5711 5682 |
| GO:0048002 |
5 |
GO:0048002 |
antigen processing and presentation of peptide antigen |
GOBP |
192 |
-0.5495682 |
0.5771990 |
down |
0.0000002 |
0.0000200 |
948 5708 114876 5688 1785 8905 1783 5706 5693 9861 10213 5686 5711 5682 135250 |
| GO:0019882 |
5 |
GO:0019882 |
antigen processing and presentation |
GOBP |
224 |
-0.4420808 |
0.6426977 |
down |
0.0000096 |
0.0005903 |
948 5708 114876 5688 1785 8905 1783 5706 5693 9861 10213 5686 5869 5711 5682 1236 135250 |
| GO:0006415 |
6 |
GO:0006415 |
translational termination |
GOBP |
171 |
-0.5994183 |
0.5491310 |
down |
0.0000000 |
0.0000026 |
64432 64978 6204 |
| GO:0006414 |
6 |
GO:0006414 |
translational elongation |
GOBP |
183 |
-0.5706623 |
0.5651510 |
down |
0.0000000 |
0.0000055 |
64432 64978 6204 |
| GO:0006413 |
6 |
GO:0006413 |
translational initiation |
GOBP |
289 |
-0.4929894 |
0.6107977 |
down |
0.0000001 |
0.0000095 |
64432 7175 5610 2332 64978 6204 |
| GO:0070126 |
6 |
GO:0070126 |
mitochondrial translational termination |
GOBP |
82 |
-0.5335703 |
0.5865072 |
down |
0.0004671 |
0.0147695 |
64432 64978 |
| GO:0032543 |
6 |
GO:0032543 |
mitochondrial translation |
GOBP |
119 |
-0.4687063 |
0.6258113 |
down |
0.0005128 |
0.0159952 |
64432 57505 64978 |
| GO:0070125 |
6 |
GO:0070125 |
mitochondrial translational elongation |
GOBP |
83 |
-0.5171374 |
0.5962248 |
down |
0.0007283 |
0.0206253 |
64432 64978 |
| GO:0070124 |
6 |
GO:0070124 |
mitochondrial translational initiation |
GOBP |
83 |
-0.5119131 |
0.5993479 |
down |
0.0008355 |
0.0226853 |
64432 64978 |
| GO:0015909 |
7 |
GO:0015909 |
long-chain fatty acid transport |
GOBP |
32 |
0.8172974 |
2.2643719 |
up |
0.0000086 |
0.0005353 |
948 2180 32 2181 788 1374 1815 |
| GO:0015908 |
7 |
GO:0015908 |
fatty acid transport |
GOBP |
42 |
0.6506982 |
1.9168786 |
up |
0.0001736 |
0.0067321 |
948 2180 32 2181 788 1374 1815 |
| GO:0015718 |
7 |
GO:0015718 |
monocarboxylic acid transport |
GOBP |
80 |
0.4496370 |
1.5677430 |
up |
0.0018593 |
0.0420720 |
948 2180 32 2181 788 1374 5205 1815 8714 |
| GO:0006259 |
8 |
GO:0006259 |
DNA metabolic process |
GOBP |
881 |
0.2393478 |
1.2704204 |
up |
0.0000178 |
0.0010187 |
10933 7415 10075 23049 5885 22992 5430 5901 6830 22985 43 11176 4928 65123 7175 8888 5591 3643 7528 55904 8243 29072 9656 10213 5426 9730 2071 22803 23054 23503 79892 55929 79813 4176 5980 8295 54108 27343 3148 472 1676 79677 7644 7405 4172 11044 5371 9984 11073 80169 1777 51203 7515 5378 5154 4171 5422 23514 11177 84515 284131 4255 22976 1647 22944 4862 1017 29089 5395 2074 11232 10714 3978 4361 5985 254394 7335 253714 2966 10635 80119 4157 25788 378708 122402 |
| GO:0006281 |
8 |
GO:0006281 |
DNA repair |
GOBP |
454 |
0.3139147 |
1.3687729 |
up |
0.0000240 |
0.0012573 |
10933 7415 10075 23049 5885 22992 5430 65123 5591 7528 8243 29072 9656 10213 5426 2071 23054 23503 5980 8295 27343 3148 472 7405 11044 5371 11073 7515 5378 5422 23514 284131 4255 1647 4862 29089 5395 2074 11232 10714 3978 4361 5985 254394 7335 253714 2966 10635 4157 25788 378708 |
| GO:0030198 |
9 |
GO:0030198 |
extracellular matrix organization |
GOBP |
308 |
-0.2908829 |
0.7476032 |
down |
0.0009216 |
0.0244479 |
11315 5802 4763 1287 9672 3791 4038 6868 5154 22795 4643 9806 255743 1310 124056 1300 |
| GO:0043062 |
9 |
GO:0043062 |
extracellular structure organization |
GOBP |
310 |
-0.2889209 |
0.7490714 |
down |
0.0009774 |
0.0254907 |
11315 5802 4763 1287 9672 3791 4038 6868 5154 22795 4643 9806 255743 1310 124056 1300 |
| GO:0031331 |
10 |
GO:0031331 |
positive regulation of cellular catabolic process |
GOBP |
235 |
-0.3563199 |
0.7002486 |
down |
0.0002388 |
0.0089601 |
7415 29763 5708 11315 5688 664 5706 859 5693 3643 51667 9861 10213 5686 6872 23001 5770 120892 51343 3091 5711 8697 5682 85409 |
| GO:0009896 |
10 |
GO:0009896 |
positive regulation of catabolic process |
GOBP |
274 |
-0.3317263 |
0.7176837 |
down |
0.0002688 |
0.0097692 |
7415 29763 5708 11315 1457 5688 664 5706 859 5693 3643 51667 9861 10213 5686 6872 23001 5770 120892 51343 3091 5711 8697 5682 85409 |
| GO:0051348 |
11 |
GO:0051348 |
negative regulation of transferase activity |
GOBP |
259 |
-0.4004082 |
0.6700465 |
down |
0.0000155 |
0.0009202 |
5502 5708 11315 5688 7249 5706 859 5693 5062 103 9861 7026 10213 5686 4763 5770 51343 5371 5711 8697 4041 5682 4085 80119 |
| GO:0006457 |
12 |
GO:0006457 |
protein folding |
GOBP |
176 |
-0.7164578 |
0.4884795 |
down |
0.0000000 |
0.0000000 |
1457 908 3303 7266 26278 4802 1155 9532 63943 81027 |
| GO:0006458 |
12 |
GO:0006458 |
'de novo' protein folding |
GOBP |
41 |
-1.0169344 |
0.3617021 |
down |
0.0000000 |
0.0000019 |
908 1155 81027 |
| GO:0051084 |
12 |
GO:0051084 |
'de novo' posttranslational protein folding |
GOBP |
36 |
-1.0194403 |
0.3607968 |
down |
0.0000001 |
0.0000060 |
908 1155 81027 |
| GO:0030258 |
12 |
GO:0030258 |
lipid modification |
GOBP |
118 |
0.5113841 |
1.6675977 |
up |
0.0000318 |
0.0016492 |
37 3032 3030 23049 8897 83752 8394 23417 8776 64781 3633 8867 8309 8395 |
| GO:0048710 |
12 |
GO:0048710 |
regulation of astrocyte differentiation |
GOBP |
8 |
-1.2760447 |
0.2791392 |
down |
0.0000419 |
0.0020814 |
274 3280 |
| GO:0042026 |
12 |
GO:0042026 |
protein refolding |
GOBP |
20 |
-1.0011151 |
0.3674695 |
down |
0.0000419 |
0.0020814 |
3303 7266 |
| GO:0030049 |
12 |
GO:0030049 |
muscle filament sliding |
GOBP |
46 |
-0.7857365 |
0.4557839 |
down |
0.0000806 |
0.0037188 |
7111 4622 |
| GO:0033275 |
12 |
GO:0033275 |
actin-myosin filament sliding |
GOBP |
47 |
-0.7857365 |
0.4557839 |
down |
0.0000806 |
0.0037188 |
7111 4622 |
| GO:0043648 |
12 |
GO:0043648 |
dicarboxylic acid metabolic process |
GOBP |
53 |
0.6318209 |
1.8810327 |
up |
0.0001316 |
0.0054246 |
445 443 728294 10873 197322 51166 23475 23498 |
| GO:0008089 |
12 |
GO:0008089 |
anterograde axon cargo transport |
GOBP |
21 |
-0.9255515 |
0.3963128 |
down |
0.0002006 |
0.0077165 |
6647 282991 |
| GO:0002062 |
12 |
GO:0002062 |
chondrocyte differentiation |
GOBP |
41 |
-0.7489112 |
0.4728812 |
down |
0.0002154 |
0.0081482 |
4208 |
| GO:0007077 |
12 |
GO:0007077 |
mitotic nuclear envelope disassembly |
GOBP |
41 |
0.6315141 |
1.8804557 |
up |
0.0003038 |
0.0107046 |
23175 91754 4928 7175 9972 55746 8021 9883 23225 9631 |
| GO:0030397 |
12 |
GO:0030397 |
membrane disassembly |
GOBP |
41 |
0.6315141 |
1.8804557 |
up |
0.0003038 |
0.0107046 |
23175 91754 4928 7175 9972 55746 8021 9883 23225 9631 |
| GO:0051081 |
12 |
GO:0051081 |
nuclear envelope disassembly |
GOBP |
41 |
0.6315141 |
1.8804557 |
up |
0.0003038 |
0.0107046 |
23175 91754 4928 7175 9972 55746 8021 9883 23225 9631 |
| GO:0019319 |
12 |
GO:0019319 |
hexose biosynthetic process |
GOBP |
55 |
-0.6683674 |
0.5125447 |
down |
0.0003088 |
0.0107978 |
2597 226 2027 5230 468 5164 8473 200186 |
| GO:0050919 |
12 |
GO:0050919 |
negative chemotaxis |
GOBP |
10 |
-1.1450275 |
0.3182152 |
down |
0.0003504 |
0.0119809 |
5154 9353 |
| GO:0032784 |
12 |
GO:0032784 |
regulation of DNA-templated transcription, elongation |
GOBP |
32 |
0.7057214 |
2.0253072 |
up |
0.0004198 |
0.0138410 |
10771 6830 7919 8861 284695 9984 2074 |
| GO:0001756 |
12 |
GO:0001756 |
somitogenesis |
GOBP |
11 |
-1.1033469 |
0.3317588 |
down |
0.0004415 |
0.0141941 |
10655 |
| GO:0043484 |
12 |
GO:0043484 |
regulation of RNA splicing |
GOBP |
72 |
0.5094406 |
1.6643599 |
up |
0.0005399 |
0.0166132 |
6625 10181 27316 5430 22985 10291 6429 57396 1198 5725 135295 |
| GO:0006094 |
12 |
GO:0006094 |
gluconeogenesis |
GOBP |
53 |
-0.6509138 |
0.5215689 |
down |
0.0006165 |
0.0184782 |
2597 226 2027 5230 468 5164 8473 200186 |
| GO:0030206 |
12 |
GO:0030206 |
chondroitin sulfate biosynthetic process |
GOBP |
24 |
-0.9161547 |
0.4000544 |
down |
0.0006562 |
0.0192937 |
79586 337876 |
| GO:1903309 |
12 |
GO:1903309 |
negative regulation of chromatin modification |
GOBP |
31 |
0.6725204 |
1.9591689 |
up |
0.0007677 |
0.0214781 |
6830 5253 54880 23133 |
| GO:0046364 |
12 |
GO:0046364 |
monosaccharide biosynthetic process |
GOBP |
58 |
-0.6154914 |
0.5403753 |
down |
0.0007849 |
0.0218251 |
2597 226 2027 5230 468 5164 8473 200186 |
| GO:0019395 |
12 |
GO:0019395 |
fatty acid oxidation |
GOBP |
78 |
0.5108890 |
1.6667722 |
up |
0.0010247 |
0.0264235 |
37 3032 3030 83752 23417 8309 |
| GO:0009062 |
12 |
GO:0009062 |
fatty acid catabolic process |
GOBP |
75 |
0.5137509 |
1.6715492 |
up |
0.0010455 |
0.0268104 |
37 3032 3030 23175 83752 23659 8309 |
| GO:0032048 |
12 |
GO:0032048 |
cardiolipin metabolic process |
GOBP |
15 |
0.9120081 |
2.4893162 |
up |
0.0010659 |
0.0270330 |
3032 3030 6901 9489 132001 |
| GO:0034440 |
12 |
GO:0034440 |
lipid oxidation |
GOBP |
80 |
0.4947626 |
1.6401088 |
up |
0.0013205 |
0.0329484 |
37 3032 3030 83752 23417 8309 |
| GO:0002689 |
12 |
GO:0002689 |
negative regulation of leukocyte chemotaxis |
GOBP |
9 |
-1.1072244 |
0.3304750 |
down |
0.0013888 |
0.0344665 |
9353 |
| GO:0007062 |
12 |
GO:0007062 |
sister chromatid cohesion |
GOBP |
33 |
0.6456425 |
1.9072121 |
up |
0.0014277 |
0.0352420 |
23126 8243 10664 79892 11044 4361 |
| GO:0006482 |
12 |
GO:0006482 |
protein demethylation |
GOBP |
22 |
0.7469452 |
2.1105429 |
up |
0.0015058 |
0.0365831 |
22992 5253 23133 23081 |
| GO:0008214 |
12 |
GO:0008214 |
protein dealkylation |
GOBP |
22 |
0.7469452 |
2.1105429 |
up |
0.0015058 |
0.0365831 |
22992 5253 23133 23081 |
| GO:0050931 |
12 |
GO:0050931 |
pigment cell differentiation |
GOBP |
16 |
-0.9245649 |
0.3967040 |
down |
0.0015178 |
0.0366817 |
4208 967 |
| GO:0061647 |
12 |
GO:0061647 |
histone H3-K9 modification |
GOBP |
15 |
0.8419214 |
2.3208220 |
up |
0.0016516 |
0.0385046 |
4297 4602 |
| GO:0072215 |
12 |
GO:0072215 |
regulation of metanephros development |
GOBP |
12 |
-0.9793547 |
0.3755534 |
down |
0.0017540 |
0.0404827 |
5154 3976 |
| GO:0010675 |
12 |
GO:0010675 |
regulation of cellular carbohydrate metabolic process |
GOBP |
86 |
0.4411248 |
1.5544548 |
up |
0.0017752 |
0.0407684 |
5164 8473 6097 3643 23417 3091 2218 5581 23178 340485 4504 |
| GO:0090101 |
12 |
GO:0090101 |
negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway |
GOBP |
92 |
-0.5065808 |
0.6025523 |
down |
0.0018232 |
0.0416619 |
90 6868 163126 10468 |
| GO:0070252 |
12 |
GO:0070252 |
actin-mediated cell contraction |
GOBP |
57 |
-0.5926242 |
0.5528745 |
down |
0.0019996 |
0.0439326 |
7111 5144 4622 |
| GO:0030204 |
12 |
GO:0030204 |
chondroitin sulfate metabolic process |
GOBP |
52 |
-0.6060176 |
0.5455190 |
down |
0.0020917 |
0.0455437 |
9672 79586 337876 135152 |
| GO:0000184 |
12 |
GO:0000184 |
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay |
GOBP |
136 |
-0.4047024 |
0.6671753 |
down |
0.0021775 |
0.0469698 |
23049 22794 5394 9704 6204 |
| GO:0090151 |
12 |
GO:0090151 |
establishment of protein localization to mitochondrial membrane |
GOBP |
11 |
-1.0474187 |
0.3508422 |
down |
0.0021955 |
0.0471367 |
3308 29928 |
| GO:0072329 |
12 |
GO:0072329 |
monocarboxylic acid catabolic process |
GOBP |
85 |
0.4591276 |
1.5826926 |
up |
0.0022548 |
0.0479632 |
37 3032 3030 23175 83752 23659 8309 18 |
| GO:1902679 |
13 |
GO:1902679 |
negative regulation of RNA biosynthetic process |
GOBP |
834 |
0.2293836 |
1.2578244 |
up |
0.0000131 |
0.0007933 |
4666 4208 604 4784 1112 7536 6304 26287 3609 8085 10771 1387 6601 2033 11176 10915 171023 7175 6945 7528 22955 4089 2114 3054 5253 8861 10664 7026 10370 23309 4194 9730 6670 7994 54880 55929 79813 5356 23468 9541 23133 3148 55841 7644 5371 83860 26013 23598 9425 57786 5629 7428 3280 862 7189 170959 6908 83595 6907 7753 5205 406 163126 55506 3665 10468 7695 8914 23119 7421 9015 84174 4602 4504 |
| GO:1903507 |
13 |
GO:1903507 |
negative regulation of nucleic acid-templated transcription |
GOBP |
821 |
0.2272123 |
1.2550962 |
up |
0.0000181 |
0.0010187 |
4666 4208 604 4784 1112 7536 6304 26287 3609 8085 10771 1387 6601 2033 11176 10915 171023 7175 6945 7528 22955 4089 2114 3054 5253 8861 10664 7026 10370 23309 4194 9730 6670 7994 54880 55929 79813 5356 23468 9541 23133 3148 55841 7644 5371 83860 26013 23598 9425 57786 5629 7428 3280 862 7189 170959 6908 83595 6907 7753 5205 406 163126 55506 3665 10468 7695 8914 23119 7421 9015 84174 4602 4504 |
| GO:0045892 |
13 |
GO:0045892 |
negative regulation of transcription, DNA-templated |
GOBP |
792 |
0.2213553 |
1.2477666 |
up |
0.0000433 |
0.0021281 |
4666 4208 604 4784 1112 6304 26287 3609 8085 10771 1387 6601 2033 11176 10915 171023 7175 6945 7528 22955 4089 2114 3054 5253 8861 10664 7026 10370 23309 4194 9730 6670 7994 54880 55929 79813 23468 9541 23133 3148 55841 7644 5371 83860 26013 23598 57786 5629 7428 3280 862 7189 170959 6908 83595 6907 7753 5205 406 163126 55506 3665 10468 7695 8914 23119 7421 9015 84174 4602 4504 |
| GO:0071559 |
14 |
GO:0071559 |
response to transforming growth factor beta |
GOBP |
214 |
-0.3434823 |
0.7092961 |
down |
0.0020082 |
0.0439326 |
4208 6667 4089 10370 90 9392 6868 867 163126 50855 |
| GO:0071560 |
14 |
GO:0071560 |
cellular response to transforming growth factor beta stimulus |
GOBP |
214 |
-0.3434823 |
0.7092961 |
down |
0.0020082 |
0.0439326 |
4208 6667 4089 10370 90 9392 6868 867 163126 50855 |
| GO:0007178 |
14 |
GO:0007178 |
transmembrane receptor protein serine/threonine kinase signaling pathway |
GOBP |
319 |
-0.3037951 |
0.7380121 |
down |
0.0021506 |
0.0466066 |
56963 6667 4089 10370 63893 90 9392 6868 867 163126 10468 50855 |
| GO:0040029 |
15 |
GO:0040029 |
regulation of gene expression, epigenetic |
GOBP |
215 |
0.3677862 |
1.4445332 |
up |
0.0001226 |
0.0052394 |
8085 11176 55904 8289 103 5253 10664 2071 29102 55929 79813 23133 63925 4343 4255 6908 126374 55506 2966 9015 122402 |
| GO:0000183 |
15 |
GO:0000183 |
chromatin silencing at rDNA |
GOBP |
19 |
0.9106080 |
2.4858334 |
up |
0.0001705 |
0.0067261 |
11176 5253 23133 6908 9015 |
| GO:0045814 |
15 |
GO:0045814 |
negative regulation of gene expression, epigenetic |
GOBP |
95 |
0.4675940 |
1.5961492 |
up |
0.0003184 |
0.0110494 |
8085 11176 5253 2071 23133 6908 55506 2966 9015 |
| GO:0006342 |
15 |
GO:0006342 |
chromatin silencing |
GOBP |
38 |
0.6434226 |
1.9029830 |
up |
0.0007353 |
0.0206967 |
8085 11176 5253 23133 6908 9015 |
| GO:0016458 |
15 |
GO:0016458 |
gene silencing |
GOBP |
103 |
0.4491233 |
1.5669379 |
up |
0.0012222 |
0.0306613 |
8085 11176 22955 103 5253 29102 23133 4343 6908 1017 126374 9015 |
| GO:0070972 |
16 |
GO:0070972 |
protein localization to endoplasmic reticulum |
GOBP |
135 |
-0.6097564 |
0.5434833 |
down |
0.0000004 |
0.0000360 |
128866 11231 6204 |
| GO:0072599 |
16 |
GO:0072599 |
establishment of protein localization to endoplasmic reticulum |
GOBP |
122 |
-0.6350220 |
0.5299238 |
down |
0.0000005 |
0.0000390 |
128866 11231 6204 |
| GO:0045047 |
16 |
GO:0045047 |
protein targeting to ER |
GOBP |
118 |
-0.6425305 |
0.5259598 |
down |
0.0000005 |
0.0000417 |
128866 11231 6204 |
| GO:0006613 |
16 |
GO:0006613 |
cotranslational protein targeting to membrane |
GOBP |
110 |
-0.6342413 |
0.5303377 |
down |
0.0000010 |
0.0000703 |
11231 6204 |
| GO:0006614 |
16 |
GO:0006614 |
SRP-dependent cotranslational protein targeting to membrane |
GOBP |
109 |
-0.6354791 |
0.5296816 |
down |
0.0000010 |
0.0000730 |
11231 6204 |
| GO:0006612 |
16 |
GO:0006612 |
protein targeting to membrane |
GOBP |
170 |
-0.3807808 |
0.6833276 |
down |
0.0006402 |
0.0189432 |
128866 4641 8394 11231 9847 64108 6204 85409 |
| GO:0090150 |
16 |
GO:0090150 |
establishment of protein localization to membrane |
GOBP |
299 |
-0.2876912 |
0.7499931 |
down |
0.0008002 |
0.0219859 |
128866 4641 3308 5534 2181 8394 2319 8500 11231 9847 10018 29928 340348 27113 64108 6204 85409 |
| GO:0007005 |
17 |
GO:0007005 |
mitochondrion organization |
GOBP |
665 |
-0.2882059 |
0.7496072 |
down |
0.0000046 |
0.0002959 |
29995 10075 10425 54543 11315 64432 22985 3308 664 53632 10449 22885 3303 5534 22918 3054 8834 55102 26521 6901 6507 2551 79133 89781 2011 120892 118424 282991 10018 29928 3280 6529 57505 11232 2553 64978 27113 202374 440738 |
| GO:0006325 |
18 |
GO:0006325 |
chromatin organization |
GOBP |
696 |
0.3476852 |
1.4157866 |
up |
0.0000000 |
0.0000020 |
10933 10075 8473 6304 6046 8085 22992 10847 1387 6830 6601 2033 11176 339287 171023 7175 55904 8289 3054 5253 6294 8861 10664 29072 93624 9913 29855 57634 23309 9070 9730 10902 114803 4297 10363 7994 54880 6885 7468 8518 56254 54904 6872 9733 55929 79813 9869 8295 54108 9739 23133 3148 23523 63925 5371 26013 10042 1911 11177 23081 22976 6907 3431 1017 3976 378708 4602 4504 |
| GO:0016568 |
18 |
GO:0016568 |
chromatin modification |
GOBP |
478 |
0.3676357 |
1.4443158 |
up |
0.0000000 |
0.0000037 |
10933 10075 8473 8085 22992 10847 1387 6830 6601 2033 11176 339287 171023 7175 55904 8289 3054 5253 8861 29072 9913 57634 23309 9070 9730 10902 114803 4297 10363 7994 54880 6885 56254 54904 6872 9733 55929 79813 8295 54108 23133 3148 63925 5371 26013 10042 1911 11177 23081 22976 6907 3431 1017 3976 378708 4602 4504 |
| GO:0016569 |
18 |
GO:0016569 |
covalent chromatin modification |
GOBP |
346 |
0.3927905 |
1.4811080 |
up |
0.0000002 |
0.0000151 |
10933 10075 8473 8085 22992 10847 1387 6830 2033 11176 339287 171023 55904 3054 8861 29072 9913 57634 23309 9070 9730 10902 114803 4297 7994 54880 6885 56254 54904 6872 9733 55929 79813 8295 23133 63925 5371 1911 23081 22976 6907 1017 3976 4602 4504 |
| GO:0016570 |
18 |
GO:0016570 |
histone modification |
GOBP |
342 |
0.3847258 |
1.4692115 |
up |
0.0000004 |
0.0000294 |
10933 10075 8473 8085 22992 10847 1387 6830 2033 11176 339287 171023 55904 3054 8861 29072 9913 57634 23309 9070 9730 10902 114803 4297 7994 54880 6885 56254 54904 6872 9733 55929 79813 8295 23133 63925 5371 1911 23081 22976 6907 1017 3976 4602 4504 |
| GO:0018205 |
18 |
GO:0018205 |
peptidyl-lysine modification |
GOBP |
237 |
0.3199328 |
1.3770352 |
up |
0.0004000 |
0.0133802 |
10933 8473 11315 8085 10847 1387 6830 2033 6612 339287 26054 55904 3054 8861 29072 9913 57634 9070 10902 4297 7994 54880 6885 6872 55929 79813 8295 63925 22976 29843 3976 4602 |
| GO:0046474 |
19 |
GO:0046474 |
glycerophospholipid biosynthetic process |
GOBP |
202 |
0.3915028 |
1.4792020 |
up |
0.0000584 |
0.0028400 |
3032 3030 23171 23175 8897 43 5298 2181 8394 81579 6901 8776 472 54872 10390 23761 9489 5154 8867 5359 9487 132001 5336 8395 123745 80339 |
| GO:0006650 |
19 |
GO:0006650 |
glycerophospholipid metabolic process |
GOBP |
256 |
0.3500905 |
1.4191960 |
up |
0.0001292 |
0.0053739 |
3032 3030 23171 23175 23049 8897 43 5298 2181 8394 81579 6901 8776 472 54872 3633 10390 23761 9489 5154 8867 5359 9487 132001 5336 8395 123745 256987 80339 |
| GO:0045017 |
19 |
GO:0045017 |
glycerolipid biosynthetic process |
GOBP |
245 |
0.3211752 |
1.3787471 |
up |
0.0004428 |
0.0141941 |
3032 3030 2180 23171 23175 8897 43 5298 2181 8394 81579 6901 8776 472 54872 10390 23761 9489 5154 8867 5359 9487 132001 5336 8395 2710 123745 80339 |
| GO:0046486 |
19 |
GO:0046486 |
glycerolipid metabolic process |
GOBP |
327 |
0.2863243 |
1.3315243 |
up |
0.0006346 |
0.0188989 |
3032 3030 2180 23171 23175 23049 8897 43 859 2167 5298 2181 8394 81579 6901 8776 472 54872 3633 10390 23761 9489 3991 5154 8867 5359 9487 132001 5336 8395 2710 123745 256987 80339 |
| GO:0008654 |
19 |
GO:0008654 |
phospholipid biosynthetic process |
GOBP |
223 |
0.3016499 |
1.3520878 |
up |
0.0017296 |
0.0401203 |
3032 3030 23171 23175 8897 43 5298 2181 8394 81579 6901 8776 472 54872 10390 23761 9489 5154 8867 5359 9487 132001 5336 8395 123745 80339 |
| GO:0006644 |
19 |
GO:0006644 |
phospholipid metabolic process |
GOBP |
319 |
0.2575288 |
1.2937290 |
up |
0.0022653 |
0.0479662 |
3032 3030 23171 23175 23049 8897 43 5298 2181 8394 81579 6901 8776 472 54872 3633 10390 23761 9489 2055 5154 8867 5359 9487 132001 5336 8395 123745 256987 1236 80339 |
| GO:0090068 |
20 |
GO:0090068 |
positive regulation of cell cycle process |
GOBP |
177 |
-0.3418629 |
0.7104456 |
down |
0.0019260 |
0.0429478 |
5708 5688 5706 5693 7175 3643 9861 10213 5686 472 5371 5711 4041 51203 835 5581 55920 5682 1017 4085 |
| GO:0022411 |
21 |
GO:0022411 |
cellular component disassembly |
GOBP |
644 |
-0.2211086 |
0.8016296 |
down |
0.0002085 |
0.0079558 |
29995 6304 23175 11315 23332 91754 64432 6601 22985 664 4928 7175 22918 5062 8289 57553 7082 9972 55102 55746 8021 9883 2059 6507 1287 3148 1676 2011 23225 1777 6868 8867 9631 63908 6529 441027 1829 64978 202374 1310 6204 440738 124056 1300 |
| GO:0051056 |
22 |
GO:0051056 |
regulation of small GTPase mediated signal transduction |
GOBP |
496 |
0.2624040 |
1.3000517 |
up |
0.0000951 |
0.0042194 |
8473 6647 9267 8874 9922 8826 4301 8394 6654 6453 23189 9827 9826 116985 19 9828 4763 9743 253959 55114 10160 54828 120892 3633 57580 9289 81846 6002 4983 9754 23229 10235 9353 55920 5924 55785 51735 79890 91614 84986 115727 440073 58504 4908 84249 1236 |
| GO:0046578 |
22 |
GO:0046578 |
regulation of Ras protein signal transduction |
GOBP |
393 |
0.2712307 |
1.3115776 |
up |
0.0002462 |
0.0091661 |
8473 6647 9267 8874 9922 8826 4301 8394 6654 6453 23189 9827 9826 116985 19 9828 4763 253959 10160 54828 120892 57580 9289 81846 6002 4983 10235 55920 55785 51735 79890 115727 440073 4908 84249 1236 |
| GO:0043547 |
22 |
GO:0043547 |
positive regulation of GTPase activity |
GOBP |
311 |
0.2946645 |
1.3426758 |
up |
0.0002729 |
0.0098426 |
9267 8874 9922 8826 4301 8394 6654 6453 9827 9826 116985 9828 4763 253959 10160 54828 120892 57580 81846 6002 4983 10235 55785 51735 79890 115727 440073 4908 84249 1236 |
| GO:0035023 |
22 |
GO:0035023 |
regulation of Rho protein signal transduction |
GOBP |
366 |
0.2654323 |
1.3039945 |
up |
0.0004629 |
0.0147346 |
6647 9267 8874 9922 8826 4301 8394 6654 6453 23189 9827 9826 116985 19 9828 4763 253959 10160 54828 120892 57580 9289 81846 6002 4983 10235 55920 55785 51735 79890 115727 440073 4908 84249 1236 |
| GO:0032489 |
22 |
GO:0032489 |
regulation of Cdc42 protein signal transduction |
GOBP |
348 |
0.2590349 |
1.2956790 |
up |
0.0008855 |
0.0236263 |
6647 9267 8874 9922 8826 4301 8394 6654 6453 9827 9826 116985 19 9828 4763 253959 10160 54828 120892 57580 81846 6002 4983 10235 55920 55785 51735 79890 115727 440073 4908 84249 1236 |
| GO:0035020 |
22 |
GO:0035020 |
regulation of Rac protein signal transduction |
GOBP |
349 |
0.2548660 |
1.2902888 |
up |
0.0010858 |
0.0273884 |
8473 6647 9267 8874 9922 8826 4301 8394 6654 6453 9827 9826 116985 9828 4763 253959 10160 54828 120892 57580 81846 6002 4983 10235 55920 55785 51735 79890 115727 440073 4908 84249 1236 |
| GO:0032012 |
22 |
GO:0032012 |
regulation of ARF protein signal transduction |
GOBP |
346 |
0.2476998 |
1.2810752 |
up |
0.0015850 |
0.0371386 |
6647 9267 8874 9922 8826 4301 8394 6654 6453 9827 9826 116985 9828 4763 253959 10160 54828 120892 57580 81846 6002 4983 10235 55920 55785 51735 79890 115727 440073 4908 84249 1236 |
| GO:0032015 |
22 |
GO:0032015 |
regulation of Ran protein signal transduction |
GOBP |
346 |
0.2476998 |
1.2810752 |
up |
0.0015850 |
0.0371386 |
6647 9267 8874 9922 8826 4301 8394 6654 6453 9827 9826 116985 9828 4763 253959 10160 54828 120892 57580 81846 6002 4983 10235 55920 55785 51735 79890 115727 440073 4908 84249 1236 |
| GO:0032483 |
22 |
GO:0032483 |
regulation of Rab protein signal transduction |
GOBP |
347 |
0.2476998 |
1.2810752 |
up |
0.0015850 |
0.0371386 |
6647 9267 8874 9922 8826 4301 8394 6654 6453 9827 9826 116985 9828 4763 253959 10160 54828 120892 57580 81846 6002 4983 10235 55920 55785 51735 79890 115727 440073 4908 84249 1236 |
| GO:0032485 |
22 |
GO:0032485 |
regulation of Ral protein signal transduction |
GOBP |
346 |
0.2476998 |
1.2810752 |
up |
0.0015850 |
0.0371386 |
6647 9267 8874 9922 8826 4301 8394 6654 6453 9827 9826 116985 9828 4763 253959 10160 54828 120892 57580 81846 6002 4983 10235 55920 55785 51735 79890 115727 440073 4908 84249 1236 |
| GO:0032487 |
22 |
GO:0032487 |
regulation of Rap protein signal transduction |
GOBP |
346 |
0.2476998 |
1.2810752 |
up |
0.0015850 |
0.0371386 |
6647 9267 8874 9922 8826 4301 8394 6654 6453 9827 9826 116985 9828 4763 253959 10160 54828 120892 57580 81846 6002 4983 10235 55920 55785 51735 79890 115727 440073 4908 84249 1236 |
| GO:0043087 |
22 |
GO:0043087 |
regulation of GTPase activity |
GOBP |
346 |
0.2476998 |
1.2810752 |
up |
0.0015850 |
0.0371386 |
6647 9267 8874 9922 8826 4301 8394 6654 6453 9827 9826 116985 9828 4763 253959 10160 54828 120892 57580 81846 6002 4983 10235 55920 55785 51735 79890 115727 440073 4908 84249 1236 |
| GO:0006977 |
23 |
GO:0006977 |
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest |
GOBP |
65 |
-0.9194492 |
0.3987386 |
down |
0.0000000 |
0.0000004 |
5708 5688 5706 5693 9861 10213 5686 472 5371 5711 835 5682 1017 |
| GO:0072431 |
23 |
GO:0072431 |
signal transduction involved in mitotic G1 DNA damage checkpoint |
GOBP |
66 |
-0.8818495 |
0.4140165 |
down |
0.0000000 |
0.0000017 |
5708 5688 5706 5693 5591 9861 10213 5686 472 5371 5711 835 5682 1017 |
| GO:1902400 |
23 |
GO:1902400 |
intracellular signal transduction involved in G1 DNA damage checkpoint |
GOBP |
66 |
-0.8818495 |
0.4140165 |
down |
0.0000000 |
0.0000017 |
5708 5688 5706 5693 5591 9861 10213 5686 472 5371 5711 835 5682 1017 |
| GO:0072413 |
23 |
GO:0072413 |
signal transduction involved in mitotic cell cycle checkpoint |
GOBP |
69 |
-0.8478448 |
0.4283371 |
down |
0.0000000 |
0.0000038 |
5708 5688 5706 5693 5591 9861 10213 5686 472 5371 5711 835 5682 1017 |
| GO:1902402 |
23 |
GO:1902402 |
signal transduction involved in mitotic DNA damage checkpoint |
GOBP |
69 |
-0.8478448 |
0.4283371 |
down |
0.0000000 |
0.0000038 |
5708 5688 5706 5693 5591 9861 10213 5686 472 5371 5711 835 5682 1017 |
| GO:1902403 |
23 |
GO:1902403 |
signal transduction involved in mitotic DNA integrity checkpoint |
GOBP |
69 |
-0.8478448 |
0.4283371 |
down |
0.0000000 |
0.0000038 |
5708 5688 5706 5693 5591 9861 10213 5686 472 5371 5711 835 5682 1017 |
| GO:0071158 |
23 |
GO:0071158 |
positive regulation of cell cycle arrest |
GOBP |
81 |
-0.7897447 |
0.4539607 |
down |
0.0000000 |
0.0000055 |
5708 5688 5706 5693 9861 10213 5686 472 5371 5711 835 5682 1017 |
| GO:0044819 |
23 |
GO:0044819 |
mitotic G1/S transition checkpoint |
GOBP |
75 |
-0.8127622 |
0.4436310 |
down |
0.0000000 |
0.0000055 |
5708 5688 5706 5693 5591 9861 10213 5686 472 5371 5711 835 5682 1017 |
| GO:0072395 |
23 |
GO:0072395 |
signal transduction involved in cell cycle checkpoint |
GOBP |
72 |
-0.8225015 |
0.4393313 |
down |
0.0000000 |
0.0000059 |
5708 5688 5706 5693 5591 9861 10213 5686 472 5371 5711 835 5682 1017 |
| GO:0031571 |
23 |
GO:0031571 |
mitotic G1 DNA damage checkpoint |
GOBP |
74 |
-0.8104328 |
0.4446656 |
down |
0.0000001 |
0.0000067 |
5708 5688 5706 5693 5591 9861 10213 5686 472 5371 5711 835 5682 1017 |
| GO:0072401 |
23 |
GO:0072401 |
signal transduction involved in DNA integrity checkpoint |
GOBP |
71 |
-0.8219026 |
0.4395945 |
down |
0.0000001 |
0.0000067 |
5708 5688 5706 5693 5591 9861 10213 5686 472 5371 5711 835 5682 1017 |
| GO:0072422 |
23 |
GO:0072422 |
signal transduction involved in DNA damage checkpoint |
GOBP |
71 |
-0.8219026 |
0.4395945 |
down |
0.0000001 |
0.0000067 |
5708 5688 5706 5693 5591 9861 10213 5686 472 5371 5711 835 5682 1017 |
| GO:0044783 |
23 |
GO:0044783 |
G1 DNA damage checkpoint |
GOBP |
75 |
-0.7822469 |
0.4573772 |
down |
0.0000002 |
0.0000165 |
5708 5688 5706 5693 5591 9861 10213 5686 472 5371 5711 835 5682 1017 |
| GO:2000134 |
23 |
GO:2000134 |
negative regulation of G1/S transition of mitotic cell cycle |
GOBP |
91 |
-0.7035730 |
0.4948142 |
down |
0.0000006 |
0.0000435 |
5708 5688 5706 5693 5591 9861 10213 5686 472 5371 5711 835 5682 1017 |
| GO:1902807 |
23 |
GO:1902807 |
negative regulation of cell cycle G1/S phase transition |
GOBP |
92 |
-0.7002493 |
0.4964615 |
down |
0.0000006 |
0.0000435 |
5708 5688 5706 5693 5591 9861 10213 5686 472 5371 5711 835 5682 1017 |
| GO:2000045 |
23 |
GO:2000045 |
regulation of G1/S transition of mitotic cell cycle |
GOBP |
108 |
-0.6158072 |
0.5402047 |
down |
0.0000034 |
0.0002334 |
5708 5688 5706 5693 5591 9861 10213 5686 472 5371 5711 835 5682 1017 |
| GO:0030330 |
23 |
GO:0030330 |
DNA damage response, signal transduction by p53 class mediator |
GOBP |
112 |
-0.6034199 |
0.5469380 |
down |
0.0000057 |
0.0003634 |
5708 5688 5706 5693 9100 9861 10213 4194 5686 472 5371 5711 835 22976 5682 1017 |
| GO:1902806 |
23 |
GO:1902806 |
regulation of cell cycle G1/S phase transition |
GOBP |
113 |
-0.5729676 |
0.5638497 |
down |
0.0000132 |
0.0007935 |
5708 5688 5706 5693 5591 9861 10213 5686 472 5371 5711 835 5682 1017 |
| GO:0072331 |
23 |
GO:0072331 |
signal transduction by p53 class mediator |
GOBP |
152 |
-0.4733254 |
0.6229274 |
down |
0.0000850 |
0.0038477 |
5164 5708 3094 5688 5706 2033 5693 9100 9861 10213 4194 5686 472 5371 5711 835 22976 5682 1017 |
| GO:0044773 |
23 |
GO:0044773 |
mitotic DNA damage checkpoint |
GOBP |
90 |
-0.5739715 |
0.5632839 |
down |
0.0000914 |
0.0040959 |
5708 1112 5688 5706 5693 5591 9861 9656 10213 5686 472 5371 5711 835 5682 1017 4361 |
| GO:0044774 |
23 |
GO:0044774 |
mitotic DNA integrity checkpoint |
GOBP |
94 |
-0.5527847 |
0.5753454 |
down |
0.0001272 |
0.0053361 |
5708 1112 5688 5706 5693 5591 9861 9656 10213 5686 472 5371 5711 835 5682 1017 4361 |
| GO:0000082 |
23 |
GO:0000082 |
G1/S transition of mitotic cell cycle |
GOBP |
210 |
-0.3651038 |
0.6941246 |
down |
0.0003248 |
0.0111875 |
5708 5688 5706 5693 5591 9861 10213 5426 5686 4176 23133 472 90 4172 5371 5711 835 6868 4171 5422 84515 5682 1017 |
| GO:0042770 |
23 |
GO:0042770 |
signal transduction in response to DNA damage |
GOBP |
127 |
-0.4440317 |
0.6414451 |
down |
0.0005858 |
0.0177904 |
5708 5688 5706 5693 5591 9100 9861 8243 10213 4194 5686 472 5371 5711 835 22976 1647 5682 1017 |
| GO:0044843 |
23 |
GO:0044843 |
cell cycle G1/S phase transition |
GOBP |
215 |
-0.3450267 |
0.7082014 |
down |
0.0006129 |
0.0184782 |
5708 5688 5706 5693 5591 9861 10213 5426 5686 4176 23133 472 90 4172 5371 5711 835 6868 4171 5422 84515 5682 1017 |
| GO:1902001 |
24 |
GO:1902001 |
fatty acid transmembrane transport |
GOBP |
13 |
1.1898146 |
3.2864719 |
up |
0.0000005 |
0.0000390 |
948 32 788 1374 |
| GO:1902603 |
24 |
GO:1902603 |
carnitine transmembrane transport |
GOBP |
8 |
1.2180362 |
3.3805424 |
up |
0.0000375 |
0.0019034 |
32 788 1374 |
| GO:0015838 |
24 |
GO:0015838 |
amino-acid betaine transport |
GOBP |
11 |
1.1016041 |
3.0089889 |
up |
0.0000760 |
0.0035791 |
32 788 1374 |
| GO:0015879 |
24 |
GO:0015879 |
carnitine transport |
GOBP |
11 |
1.1016041 |
3.0089889 |
up |
0.0000760 |
0.0035791 |
32 788 1374 |
| GO:0015697 |
24 |
GO:0015697 |
quaternary ammonium group transport |
GOBP |
12 |
1.0457632 |
2.8455693 |
up |
0.0001251 |
0.0052973 |
32 788 1374 |
| GO:0072488 |
24 |
GO:0072488 |
ammonium transmembrane transport |
GOBP |
10 |
1.0730368 |
2.9242463 |
up |
0.0001418 |
0.0057426 |
32 788 1374 |
| GO:0032365 |
24 |
GO:0032365 |
intracellular lipid transport |
GOBP |
22 |
0.7963514 |
2.2174356 |
up |
0.0007232 |
0.0206253 |
32 788 19 1374 |
| GO:0006396 |
25 |
GO:0006396 |
RNA processing |
GOBP |
653 |
0.2940308 |
1.3418252 |
up |
0.0000042 |
0.0002790 |
23524 10521 3190 10594 6430 6625 7536 9584 2521 23020 10250 10181 27316 79869 11100 5430 3191 6830 22985 7919 5411 3303 10291 6429 9169 57396 103 8243 11168 11051 1198 23070 2071 5725 22803 29102 4850 56254 9733 4849 8621 5356 10907 25929 23398 284695 51755 9984 4343 56919 8446 96764 28960 9704 22944 10465 26747 57461 11157 64852 90459 2966 122402 135295 |
| GO:0000375 |
25 |
GO:0000375 |
RNA splicing, via transesterification reactions |
GOBP |
361 |
0.3636115 |
1.4385153 |
up |
0.0000191 |
0.0010262 |
23524 3190 10594 6430 6625 7536 2521 23020 10250 10181 27316 79869 11100 5430 3191 22985 7919 5411 10291 6429 9169 8243 11168 11051 5725 9733 8621 5356 10907 25929 23398 96764 28960 10465 57461 11157 135295 |
| GO:0000377 |
25 |
GO:0000377 |
RNA splicing, via transesterification reactions with bulged adenosine as nucleophile |
GOBP |
353 |
0.3656684 |
1.4414772 |
up |
0.0000191 |
0.0010262 |
23524 3190 10594 6430 6625 7536 2521 23020 10250 10181 27316 79869 11100 5430 3191 22985 7919 5411 10291 6429 9169 8243 11168 11051 5725 9733 8621 5356 10907 25929 23398 96764 28960 10465 57461 11157 135295 |
| GO:0000398 |
25 |
GO:0000398 |
mRNA splicing, via spliceosome |
GOBP |
353 |
0.3656684 |
1.4414772 |
up |
0.0000191 |
0.0010262 |
23524 3190 10594 6430 6625 7536 2521 23020 10250 10181 27316 79869 11100 5430 3191 22985 7919 5411 10291 6429 9169 8243 11168 11051 5725 9733 8621 5356 10907 25929 23398 96764 28960 10465 57461 11157 135295 |
| GO:0006397 |
25 |
GO:0006397 |
mRNA processing |
GOBP |
486 |
0.3082494 |
1.3610404 |
up |
0.0000345 |
0.0017715 |
23524 3190 10594 6430 6625 7536 2521 23020 10250 10181 27316 79869 11100 5430 3191 6830 22985 7919 5411 3303 10291 6429 9169 8243 11168 11051 23070 2071 5725 4850 56254 9733 4849 8621 5356 10907 25929 23398 4343 96764 28960 22944 10465 57461 11157 64852 2966 135295 |
| GO:0008380 |
25 |
GO:0008380 |
RNA splicing |
GOBP |
442 |
0.3075939 |
1.3601485 |
up |
0.0000760 |
0.0035791 |
23524 3190 10594 6430 6625 7536 2521 23020 10250 10181 27316 79869 11100 5430 3191 22985 7919 5411 10291 6429 9169 57396 8243 11168 11051 1198 5725 9733 8621 5356 10907 25929 23398 284695 51755 96764 28960 10465 57461 11157 135295 |
| GO:0042752 |
26 |
GO:0042752 |
regulation of circadian rhythm |
GOBP |
74 |
0.4934541 |
1.6379642 |
up |
0.0007272 |
0.0206253 |
6097 5591 5371 5629 406 8914 3061 1815 |
| GO:0007623 |
26 |
GO:0007623 |
circadian rhythm |
GOBP |
153 |
0.3869832 |
1.4725318 |
up |
0.0008433 |
0.0227638 |
468 8473 6097 2033 5591 4297 5371 1374 5629 10743 4862 406 8914 3061 1815 |
| GO:0043624 |
27 |
GO:0043624 |
cellular protein complex disassembly |
GOBP |
227 |
-0.5001046 |
0.6064672 |
down |
0.0000002 |
0.0000151 |
23332 64432 57553 2059 8867 63908 64978 6204 |
| GO:0032984 |
27 |
GO:0032984 |
macromolecular complex disassembly |
GOBP |
259 |
-0.4165093 |
0.6593444 |
down |
0.0000044 |
0.0002921 |
23332 64432 6601 664 8289 57553 2059 8867 63908 64978 6204 |
| GO:0043241 |
27 |
GO:0043241 |
protein complex disassembly |
GOBP |
247 |
-0.4131690 |
0.6615504 |
down |
0.0000081 |
0.0005108 |
23332 64432 6601 664 8289 57553 2059 8867 63908 64978 6204 |
| GO:0006412 |
28 |
GO:0006412 |
translation |
GOBP |
691 |
-0.3909800 |
0.6763937 |
down |
0.0000000 |
0.0000037 |
2597 3488 4666 3609 23185 64432 7175 26058 6311 5610 5371 2332 57505 64978 23178 2966 54938 64506 6204 |
| GO:0051352 |
29 |
GO:0051352 |
negative regulation of ligase activity |
GOBP |
74 |
-0.9823886 |
0.3744157 |
down |
0.0000000 |
0.0000000 |
5708 11315 5688 5706 5693 9861 10213 5686 51343 5711 8697 5682 4085 |
| GO:0051444 |
29 |
GO:0051444 |
negative regulation of ubiquitin-protein transferase activity |
GOBP |
74 |
-0.9823886 |
0.3744157 |
down |
0.0000000 |
0.0000000 |
5708 11315 5688 5706 5693 9861 10213 5686 51343 5711 8697 5682 4085 |
| GO:0051443 |
29 |
GO:0051443 |
positive regulation of ubiquitin-protein transferase activity |
GOBP |
87 |
-0.9260408 |
0.3961189 |
down |
0.0000000 |
0.0000000 |
5708 5688 5706 5693 9861 10213 5686 51343 5711 8697 5682 27338 |
| GO:0051436 |
29 |
GO:0051436 |
negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle |
GOBP |
67 |
-0.9888267 |
0.3720129 |
down |
0.0000000 |
0.0000000 |
5708 5688 5706 5693 9861 10213 5686 51343 5711 8697 5682 4085 |
| GO:0051351 |
29 |
GO:0051351 |
positive regulation of ligase activity |
GOBP |
90 |
-0.9016753 |
0.4058891 |
down |
0.0000000 |
0.0000000 |
5708 5688 5706 5693 9861 10213 5686 51343 5711 8697 5682 27338 |
| GO:2000060 |
29 |
GO:2000060 |
positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process |
GOBP |
79 |
-0.9313346 |
0.3940275 |
down |
0.0000000 |
0.0000000 |
5708 5688 5706 859 5693 9861 10213 5686 51343 5711 8697 5682 |
| GO:0051438 |
29 |
GO:0051438 |
regulation of ubiquitin-protein transferase activity |
GOBP |
105 |
-0.8531020 |
0.4260911 |
down |
0.0000000 |
0.0000000 |
5708 11315 5688 5706 5693 9861 10213 5686 51343 5711 8697 5682 1017 27338 4085 |
| GO:0051437 |
29 |
GO:0051437 |
positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition |
GOBP |
71 |
-0.9559475 |
0.3844477 |
down |
0.0000000 |
0.0000000 |
5708 5688 5706 5693 9861 10213 5686 51343 5711 8697 5682 |
| GO:2000058 |
29 |
GO:2000058 |
regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process |
GOBP |
86 |
-0.8779803 |
0.4156215 |
down |
0.0000000 |
0.0000000 |
5708 5688 5706 859 5693 9861 10213 5686 51343 5371 5711 8697 5682 |
| GO:0051340 |
29 |
GO:0051340 |
regulation of ligase activity |
GOBP |
109 |
-0.8195598 |
0.4406256 |
down |
0.0000000 |
0.0000000 |
5708 11315 5688 5706 5693 9861 10213 5686 51343 5711 8697 5682 1017 27338 4085 |
| GO:0031397 |
29 |
GO:0031397 |
negative regulation of protein ubiquitination |
GOBP |
109 |
-0.7953466 |
0.4514247 |
down |
0.0000000 |
0.0000001 |
8473 5708 11315 5688 5706 3303 5693 9861 10213 5686 9683 51343 5371 5711 8697 5682 4085 |
| GO:0051439 |
29 |
GO:0051439 |
regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle |
GOBP |
79 |
-0.8838757 |
0.4131785 |
down |
0.0000000 |
0.0000001 |
5708 5688 5706 5693 9861 10213 5686 51343 5711 8697 5682 1017 4085 |
| GO:1903321 |
29 |
GO:1903321 |
negative regulation of protein modification by small protein conjugation or removal |
GOBP |
113 |
-0.7643068 |
0.4656566 |
down |
0.0000000 |
0.0000002 |
8473 5708 11315 5688 5706 3303 5693 9861 10213 5686 9683 51343 5371 5711 8697 5682 4085 |
| GO:0044092 |
30 |
GO:0044092 |
negative regulation of molecular function |
GOBP |
724 |
-0.2040484 |
0.8154229 |
down |
0.0003991 |
0.0133802 |
5502 5708 11315 1457 5688 7249 5706 9665 859 5087 5693 8826 5062 103 9861 7026 10213 29855 5686 23032 4763 5770 23523 10160 54828 120892 51343 5371 23076 83860 5711 8697 4041 5629 84240 5581 9353 55920 170959 5682 6608 83596 3656 5272 9478 2912 4085 80119 1815 50859 23504 4504 |
| GO:0043086 |
30 |
GO:0043086 |
negative regulation of catalytic activity |
GOBP |
543 |
-0.2272311 |
0.7967366 |
down |
0.0005232 |
0.0162089 |
5502 5708 11315 1457 5688 7249 5706 9665 859 5693 8826 5062 103 9861 7026 10213 29855 5686 4763 5770 23523 10160 54828 120892 51343 5371 23076 5711 8697 4041 84240 9353 55920 5682 83596 5272 9478 2912 4085 80119 1815 50859 23504 4504 |
| GO:0006405 |
31 |
GO:0006405 |
RNA export from nucleus |
GOBP |
89 |
0.4339433 |
1.5433314 |
up |
0.0018982 |
0.0425355 |
6430 10250 23049 6830 7919 6429 7175 29072 9972 55746 65083 9984 |
| GO:0006403 |
31 |
GO:0006403 |
RNA localization |
GOBP |
108 |
0.3934567 |
1.4820951 |
up |
0.0022337 |
0.0477355 |
6430 10250 23049 6830 7919 6429 7175 5394 29072 9972 6311 55746 65083 9984 |
| GO:0051568 |
32 |
GO:0051568 |
histone H3-K4 methylation |
GOBP |
32 |
0.9126892 |
2.4910125 |
up |
0.0000008 |
0.0000547 |
8473 8085 55904 9070 4297 54880 63925 22976 4602 |
| GO:0034968 |
32 |
GO:0034968 |
histone lysine methylation |
GOBP |
56 |
0.6805448 |
1.9749534 |
up |
0.0000172 |
0.0010043 |
8473 8085 6830 55904 29072 9070 4297 54880 63925 22976 4602 |
| GO:0051569 |
32 |
GO:0051569 |
regulation of histone H3-K4 methylation |
GOBP |
13 |
1.0675910 |
2.9083648 |
up |
0.0000180 |
0.0010187 |
8473 4297 54880 22976 4602 |
| GO:0018022 |
32 |
GO:0018022 |
peptidyl-lysine methylation |
GOBP |
66 |
0.6400323 |
1.8965421 |
up |
0.0000189 |
0.0010262 |
8473 8085 6830 55904 29072 9070 4297 54880 79813 63925 22976 4602 |
| GO:0031060 |
32 |
GO:0031060 |
regulation of histone methylation |
GOBP |
24 |
0.8307559 |
2.2950530 |
up |
0.0000822 |
0.0037565 |
8473 6830 4297 54880 22976 4602 |
| GO:0016571 |
32 |
GO:0016571 |
histone methylation |
GOBP |
78 |
0.5686454 |
1.7658734 |
up |
0.0001086 |
0.0046852 |
8473 8085 6830 55904 29072 9070 4297 54880 54904 79813 63925 22976 4602 |
| GO:0051571 |
32 |
GO:0051571 |
positive regulation of histone H3-K4 methylation |
GOBP |
11 |
1.0115027 |
2.7497300 |
up |
0.0002611 |
0.0095663 |
8473 4297 22976 4602 |
| GO:1903308 |
32 |
GO:1903308 |
regulation of chromatin modification |
GOBP |
81 |
0.4601592 |
1.5843261 |
up |
0.0008757 |
0.0235008 |
8473 6830 7175 5253 4297 54880 56254 9733 23133 5371 22976 3976 4602 |
| GO:1902275 |
32 |
GO:1902275 |
regulation of chromatin organization |
GOBP |
87 |
0.4285161 |
1.5349781 |
up |
0.0014986 |
0.0365831 |
8473 6830 7175 5253 4297 54880 56254 9733 23133 5371 22976 3976 4602 |
| GO:0031145 |
33 |
GO:0031145 |
anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process |
GOBP |
112 |
-0.6582468 |
0.5177583 |
down |
0.0000007 |
0.0000539 |
5708 1457 5688 5706 5693 7175 9861 10213 5686 472 51343 5711 8697 5682 1017 27338 4085 |
| GO:1901991 |
33 |
GO:1901991 |
negative regulation of mitotic cell cycle phase transition |
GOBP |
138 |
-0.4589992 |
0.6319158 |
down |
0.0001690 |
0.0067261 |
5708 1457 5688 5706 5693 7175 5591 9861 10213 5686 472 5371 5711 8697 835 5682 1017 4085 |
| GO:1901988 |
33 |
GO:1901988 |
negative regulation of cell cycle phase transition |
GOBP |
144 |
-0.4379691 |
0.6453457 |
down |
0.0002561 |
0.0094564 |
5708 1457 5688 5706 5693 7175 5591 9861 10213 5686 472 5371 5711 8697 835 5682 1017 4085 |
| GO:1901990 |
33 |
GO:1901990 |
regulation of mitotic cell cycle phase transition |
GOBP |
185 |
-0.3379990 |
0.7131960 |
down |
0.0019858 |
0.0439326 |
5708 1457 5688 5706 5693 7175 5591 9861 10213 2071 5686 472 5371 5711 8697 835 55920 5682 1017 4085 |
| GO:0035966 |
34 |
GO:0035966 |
response to topologically incorrect protein |
GOBP |
143 |
-0.4327120 |
0.6487473 |
down |
0.0004771 |
0.0149803 |
27129 37 468 7415 10106 3308 2033 3303 10113 8720 51283 1388 5770 10018 27113 |
| GO:0006986 |
34 |
GO:0006986 |
response to unfolded protein |
GOBP |
135 |
-0.4337121 |
0.6480988 |
down |
0.0006877 |
0.0199642 |
27129 37 468 7415 10106 3308 2033 3303 10113 8720 51283 1388 5770 10018 27113 |
| GO:0010648 |
35 |
GO:0010648 |
negative regulation of cell communication |
GOBP |
842 |
-0.1753144 |
0.8391932 |
down |
0.0018592 |
0.0420720 |
3488 23171 8837 5708 11315 6387 5688 128866 10771 43 7249 5706 10449 3303 8874 1500 859 171023 5693 9861 23189 10213 22900 9968 51283 5686 4763 5770 90 120892 55841 3091 2218 9737 5711 10042 4038 6812 6868 9353 22881 5682 55764 867 126374 406 163126 10468 10293 2966 84174 5196 3976 129293 85409 7498 |
| GO:0023057 |
35 |
GO:0023057 |
negative regulation of signaling |
GOBP |
839 |
-0.1755772 |
0.8389727 |
down |
0.0018709 |
0.0421273 |
3488 23171 8837 5708 11315 6387 5688 10771 43 7249 5706 10449 3303 8874 1500 859 171023 5693 9861 23189 10213 22900 9968 51283 5686 4763 5770 90 120892 55841 3091 2218 9737 5711 10042 4038 6812 6868 9353 22881 5682 55764 867 126374 406 163126 10468 10293 2966 84174 5196 3976 129293 85409 7498 |
| GO:0031398 |
36 |
GO:0031398 |
positive regulation of protein ubiquitination |
GOBP |
144 |
-0.6736180 |
0.5098606 |
down |
0.0000000 |
0.0000013 |
5708 5688 5706 859 5693 9861 10213 5686 56254 10892 120892 51343 5711 8697 7189 22976 5682 27338 378708 |
| GO:1903322 |
36 |
GO:1903322 |
positive regulation of protein modification by small protein conjugation or removal |
GOBP |
154 |
-0.6398059 |
0.5273948 |
down |
0.0000000 |
0.0000025 |
7415 5708 5688 5706 859 5693 9861 10213 5686 56254 9733 10892 120892 51343 5711 8697 7189 22976 5682 27338 378708 |
| GO:0031396 |
36 |
GO:0031396 |
regulation of protein ubiquitination |
GOBP |
206 |
-0.5683960 |
0.5664333 |
down |
0.0000000 |
0.0000038 |
8473 5708 11315 5688 5706 3303 859 5693 9861 10213 5686 56254 9683 10892 120892 51343 5371 5711 8697 7189 22976 5682 1017 27338 4085 378708 |
| GO:1903320 |
36 |
GO:1903320 |
regulation of protein modification by small protein conjugation or removal |
GOBP |
221 |
-0.5234911 |
0.5924486 |
down |
0.0000001 |
0.0000133 |
7415 8473 5708 11315 5688 5706 3303 859 5693 9861 10213 5686 56254 9733 9683 10892 120892 51343 5371 5711 8697 7189 22976 5682 1017 27338 4085 378708 |
| GO:0003012 |
37 |
GO:0003012 |
muscle system process |
GOBP |
287 |
-0.3221168 |
0.7246136 |
down |
0.0009641 |
0.0254290 |
226 844 23676 7111 29995 8837 6640 26287 786 6647 1180 5144 859 10174 2548 9826 6901 10539 6327 6548 4622 |
| GO:1903050 |
38 |
GO:1903050 |
regulation of proteolysis involved in cellular protein catabolic process |
GOBP |
251 |
-0.3346453 |
0.7155918 |
down |
0.0003928 |
0.0133319 |
7415 5708 9098 11315 1457 5688 5706 859 5693 7175 9100 51667 9861 10213 57602 5686 6872 9683 23032 472 120892 51343 5371 5711 8697 5682 4085 85409 |
| GO:1903362 |
38 |
GO:1903362 |
regulation of cellular protein catabolic process |
GOBP |
258 |
-0.3112894 |
0.7325018 |
down |
0.0008296 |
0.0226584 |
7415 5708 9098 11315 1457 5688 5706 859 5693 7175 9100 51667 9861 10213 57602 5686 9827 6872 9683 23032 472 120892 51343 5371 5711 8697 5682 4085 85409 |
| GO:0042517 |
39 |
GO:0042517 |
positive regulation of tyrosine phosphorylation of Stat3 protein |
GOBP |
18 |
-0.9547122 |
0.3849229 |
down |
0.0004087 |
0.0135714 |
3570 3280 1270 3976 |
| GO:0042503 |
39 |
GO:0042503 |
tyrosine phosphorylation of Stat3 protein |
GOBP |
24 |
-0.8266337 |
0.4375196 |
down |
0.0010020 |
0.0259848 |
3570 3280 1270 3976 |
| GO:0042516 |
39 |
GO:0042516 |
regulation of tyrosine phosphorylation of Stat3 protein |
GOBP |
23 |
-0.8363214 |
0.4333015 |
down |
0.0010569 |
0.0269541 |
3570 3280 1270 3976 |
| GO:1903052 |
40 |
GO:1903052 |
positive regulation of proteolysis involved in cellular protein catabolic process |
GOBP |
131 |
-0.6368290 |
0.5289671 |
down |
0.0000001 |
0.0000134 |
7415 5708 5688 5706 859 5693 51667 9861 10213 5686 6872 120892 51343 5711 8697 5682 85409 |
| GO:1903364 |
40 |
GO:1903364 |
positive regulation of cellular protein catabolic process |
GOBP |
133 |
-0.6251937 |
0.5351577 |
down |
0.0000002 |
0.0000182 |
7415 5708 5688 5706 859 5693 51667 9861 10213 5686 6872 120892 51343 5711 8697 5682 85409 |
| GO:0045732 |
40 |
GO:0045732 |
positive regulation of protein catabolic process |
GOBP |
186 |
-0.5396738 |
0.5829384 |
down |
0.0000003 |
0.0000285 |
7415 29763 5708 1457 5688 5706 859 5693 51667 9861 10213 5686 6872 120892 51343 5711 8697 5682 85409 |
| GO:0006521 |
41 |
GO:0006521 |
regulation of cellular amino acid metabolic process |
GOBP |
54 |
-1.2299813 |
0.2922980 |
down |
0.0000000 |
0.0000000 |
5708 11315 5688 5706 5693 9861 10213 5686 5711 5682 |
| GO:0033238 |
41 |
GO:0033238 |
regulation of cellular amine metabolic process |
GOBP |
64 |
-1.0920375 |
0.3355321 |
down |
0.0000000 |
0.0000000 |
5708 11315 5688 5706 5693 9861 2181 10213 5686 5711 5682 1815 |
| GO:0002479 |
41 |
GO:0002479 |
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent |
GOBP |
71 |
-0.9409407 |
0.3902605 |
down |
0.0000000 |
0.0000000 |
948 5708 5688 5706 5693 9861 10213 5686 5711 5682 |
| GO:0042590 |
41 |
GO:0042590 |
antigen processing and presentation of exogenous peptide antigen via MHC class I |
GOBP |
73 |
-0.9199478 |
0.3985399 |
down |
0.0000000 |
0.0000000 |
948 5708 5688 5706 5693 9861 10213 5686 5711 5682 |
| GO:0002474 |
41 |
GO:0002474 |
antigen processing and presentation of peptide antigen via MHC class I |
GOBP |
104 |
-0.7796110 |
0.4585844 |
down |
0.0000000 |
0.0000009 |
948 5708 5688 5706 5693 9861 10213 5686 5711 5682 135250 |
| GO:0044106 |
42 |
GO:0044106 |
cellular amine metabolic process |
GOBP |
165 |
-0.4433025 |
0.6419130 |
down |
0.0001413 |
0.0057426 |
5708 23175 11315 5688 43 5706 5693 9861 2181 10213 81579 5686 10390 5711 125061 5682 51166 113451 123745 23498 1815 |
| GO:0006520 |
42 |
GO:0006520 |
cellular amino acid metabolic process |
GOBP |
388 |
-0.2977986 |
0.7424509 |
down |
0.0004251 |
0.0139177 |
468 5708 11315 5688 5706 4548 5693 3712 9861 6533 6821 10213 81579 5686 445 443 51380 790 5711 670 125061 1497 5682 57505 5359 51166 18 80150 123745 23498 54938 256987 |
| GO:0009308 |
42 |
GO:0009308 |
amine metabolic process |
GOBP |
171 |
-0.3858963 |
0.6798410 |
down |
0.0007911 |
0.0218663 |
5708 23175 11315 5688 43 5706 5693 9861 2181 10213 81579 5686 10390 5711 125061 5682 51166 113451 123745 23498 1815 6819 |
| GO:0090263 |
43 |
GO:0090263 |
positive regulation of canonical Wnt signaling pathway |
GOBP |
111 |
-0.6112025 |
0.5426979 |
down |
0.0000037 |
0.0002522 |
5708 5688 5706 5693 9861 10213 5686 65981 5711 4041 5682 406 |
| GO:0030177 |
43 |
GO:0030177 |
positive regulation of Wnt signaling pathway |
GOBP |
134 |
-0.4708204 |
0.6244897 |
down |
0.0001574 |
0.0063162 |
5708 1457 5688 5706 5693 9861 23189 10213 5686 65981 5711 4041 10927 5682 406 |
| GO:0042787 |
44 |
GO:0042787 |
protein ubiquitination involved in ubiquitin-dependent protein catabolic process |
GOBP |
147 |
-0.4684230 |
0.6259887 |
down |
0.0001019 |
0.0044784 |
25831 10075 5708 10425 23352 255488 5688 5706 859 5693 283450 9861 10213 51283 5686 51343 5371 5711 8697 5682 55008 51191 |
| GO:0000209 |
44 |
GO:0000209 |
protein polyubiquitination |
GOBP |
187 |
-0.4180940 |
0.6583003 |
down |
0.0001073 |
0.0046731 |
10075 5708 10425 5688 5706 23608 5693 9861 10213 23759 51283 5686 63893 56254 6049 51343 118424 5711 8697 7189 5682 29089 81844 7335 27338 |
| GO:0042176 |
45 |
GO:0042176 |
regulation of protein catabolic process |
GOBP |
338 |
-0.2900974 |
0.7481907 |
down |
0.0004367 |
0.0141941 |
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