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ORDERED SUBSETS ANALYSIS
OSA allows the researcher to evaluate evidence for linkage even when
heterogeneity is present in a data set. This is not an unusual occurrence
when studying diseases of complex origin. Families are ranked by covariate
values in order to test evidence for linkage among homogeneous subsets of
families. Because families are ranked, a priori covariate cutpoints are not
necessary. Covariates may include linkage evidence at other genes,
environmental exposures, or biological trait values such as cholesterol,
age at onset, and so on.
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