The MQLS program for case-control association testing with related individals using genotype or allele dosage data
| This website provides our implementation of
the efficient method, MQLS, developed by Thornton and McPeek (2007). It
can handle arbitrary number of markers and samples and have other features
that we found useful in our studies, such as pedigree checking and input/output
formats. In addition to genotyped markers, this version can carry out association tests using imputed allele counts ("dosages") generated by MACH and an empirical variance estimator. The
program uses QTDT/MERLIN/LINKAGE
format as the input format and outputs the association test results for
each marker and affection status in a table format. |
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| Comments and suggestions are appreciated. Please
email me: lliang@hsph.harvard.edu. |
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Pre-compiled and instruction downloads: |
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Linux |
MQLS.tar.gz(64bit), MQLS_32bit.tar.gz (32bit) |
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Mac |
MQLS_Mac.tar.gz (64bit), MQLS_Mac_32bit.tar.gz (32bit) (Thanks Xiaowei for making this available!), more trick for Mac user. |
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Windows |
MQLS.zip |
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Citation: |
If you are using this package, please cite
this website and the reference below. |
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Reference for the MQLS method: |
Thornton T., McPeek M. S. (2007) Case-Control Association Testing with
Related Individuals: A More Powerful Quasi-Likelihood Score Test. Am
J Hum Genet, 81, 321-337. |
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