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mRNA by SNP Browser v 1.0.1

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Liming Liang,
Wei Chen,
Goncalo Abecasis

Setup file for Windows (last update: 2007.10.29), full dataset (size=513,101,473bytes). In addition to browsing the results by transcript or by position, results can be searched for information on specific SNPs. LD and tag information is provided for SNPs not in our database but evaluated by the International HapMap Consortium.
Setup file for Windows with smaller (LOD>=3) dataset (last update: 2007.10.12, size=103Mb)
Use the flat files if you want to incorporate the dataset into your own database (last update: 2007.10.12, 466Mb, description included).
Executable and full dataset for Linux (last update: 2007.10.29, 500Mb). You need X window installed for this graphical interface program


A description and instruction for the package (last update: 2007.10.29)


Dixon AL*, Liang L*, Moffatt MF*, Chen W, Heath S, Wong KCC, Taylor J, Gut I, Farrall M, Lathrop GM, Abecasis GR, Cookson WOC (2007). A whole-genome association study of global gene expression. Nat Genet 39, 1202-1207 | doi:10.1038/ng2109 [PDF]

Moffatt MF*, Kabesch M*, Liang L*, Dixon AL, Strachan D, Heath S, Depner M, von Berg A, Bufe A, Rietschel E, Heinzmann A, Simma B, Frischer T, Willis-Owen SAG, Wong KCC, Illig T, Vogelberg C, Weiland SK, von Mutius E, Abecasis GR3, Farrall M, Gut IG, Lathrop GM, Cookson WOC (2007) Genetic variants regulating ORMDL3 expression are determinants of susceptibility to childhood asthma. Nature 448, 470-473 [PDF]

* joint first authors

Update History:
2007.10.29 -- Version number increased to 1.0.1. The "query by position" mode is now 10x faster. A Linux version of the browser is now available for download. This update affects the browsers with full dataset only.

2007.10.12 -- Fixed display of the total heritability for each probeset. The previous version displayed an estimate of overall heritability computed before applying the inverse-normal transformation, and was thus slightly different from results in the paper. This fix affects both the browser and flat file downloads.


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