Past Years Journal Club

2008-2009
2007-2008
2006-2007
2005-2006
2004-2005
2003-2004
2002-2003

2008-2009

Tuesday, September 30, 2008 03:00PM Crossroads, Community Lounge

Presenter:Matt Zawistowski
Common and rare variants in multifactorial susceptibility to common diseases.
    Nat Genet (2008) 40:695-701. Bodmer W, Bonilla C.
URL:http://www.nature.com/ng/journal/v40/n6/abs/ng.f.136.html

Tuesday, October 14, 2008 04:00PM SPH Crossroads, Community Lounge

Presenter:Shyam Gopalakrishnan
Methods for detecting associations with rare variants for common diseases: application to analysis of sequence data.
    AJHG. 2008 83:311-21. Li B, Leal SM.
URL:http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B8JDD-4T5BRBT-1-2&_cdi=43612&_user=99318&_coverDate=09%2F12%2F2008&_sk=%23TOC%2343612%232008%23999169996%23697622%23FLA%23display%23Volume_83,_Issue_3,_Pages_297-430_(12_September_2008)%23tagged%23Vo

Tuesday, October 28, 2008 03:00PM SPH II Rm M1122

Presenter:Tanya Teslovich
Multiple rare variants in NPC1L1 associated with reduced sterol absorption and plasma low-density lipoprotein levels.
    Proc Natl Acad Sci U S A. 2006 103:1810-5. Cohen JC, Pertsemlidis A, Fahmi S, Esmail S, Vega GL, Grundy SM, Hobbs HH.
URL:http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=1413637&blobtype=pdf

Tuesday, November 18, 2008 TBA

Presenter:NA
ASHG Summary
    TBA
URL:http://TBA

Tuesday, January 27, 2009 03:00PM SPH II CR 2610

Presenter:Steve Qin
Accurate whole human genome sequencing using reversible terminator chemistry.
    Nature (2008) 456:49-51. Bentley DR et al.
URL:http://www.nature.com.proxy.lib.umich.edu/nature/journal/v456/n7218/pdf/nature07517.pdf

Thursday, February 19, 2009 03:00PM SPH II CR 2610

Presenter:Jun Ding
Mapping of Expression-QTLs Yields Insight into Human Gene High-Resolution Regulation.
    (2008) PLoS Genet 4: e1000214. doi:10.1371/journal.pgen.1000214, Veyrieras J-B, Kudaravalli S, Kim SY, Dermitzakis ET, Gilad Y, et al.
URL:http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1000214

Tuesday, March 03, 2009 03:00PM 2610 CR SPH

Presenter:Ming Hu
High-resolution mapping of copy-number alterations with massively parallel sequencing.
    Nat Methods. 2009 Jan;6(1):99-103. Chiang DY, Getz G, Jaffe DB, O'Kelly MJ, Zhao X, Carter SL, Russ C, Nusbaum C, Meyerson M, Lander ES.
URL:http://NA

Tuesday, March 17, 2009 03:00PM 2610 CR SPH

Presenter:Jun Li
A technical appraisal of RNASeq
    N/A
URL:http://N/A

Tuesday, March 31, 2009 03:00PM CR 2610, SPH

Presenter:Ryan Welch
Pathway analysis of seven common diseases assessed by genome-wide association.
    Genomics 2008, 92:265-272. Torkamani A, Topol EJ, Schork NJ.
URL:http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WG1-4TFV91X-2&_user=99318&_coverDate=11%2F30%2F2008&_alid=893193928&_rdoc=20&_fmt=high&_orig=search&_cdi=6809&_sort=d&_docanchor=&view=c&_ct=69&_acct=C000007678&_version=1&_urlVersion=0&_userid=99

Tuesday, April 14, 2009 03:00PM 2610 Crossroads SPH

Presenter:Wei Chen
Mapping short DNA sequencing reads and calling variants using mapping quality scores.
    Genome Res. 2008 18: 1851-1858. Li H, Ruan J, Durbin R.
URL:http://genome.cshlp.org.proxy.lib.umich.edu/content/18/11/1851.full.pdf+html?sid=b2be965b-4668-43d8-876d-3b59091a1ab6

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2007-2008

Thursday, September 06, 2007 03:00PM Crossroads 2690

Presenter:Weihua Guan
A Bayesian Approach to Copy-Number Polymorphism Analysis in Nuclear Pedigrees
    ASHG, August 8, 2007 on line publication. Konstantina Kosta, Ian Sabroe, Jonathan Gke, Robert J. Nibbs, John Tsanakas, Moira K. Whyte, and M. Dawn Teare
URL:http://www.journals.uchicago.edu.proxy.lib.umich.edu/AJHG/journal/issues/v81n4/44722/44722.web.pdf\r\n

Thursday, November 15, 2007 09:00AM Biostatistics Conference Room, M4034, SPH II

Presenter:NA
ASHG Review
    NA
URL:http://NA

Monday, January 28, 2008 03:00PM SPH Crossroads 2695

Presenter:Matt Zawistowski
Evidence of Still-Ongoing Convergence Evolution of the Lactase Persistence T-13190 Alleles in Humans
    AJHG (2007) 81:615-625 . Enattah et al.
URL:http://www.ajhg.org/AJHG/abstract/S0002-9297(07)61358-5

Monday, February 11, 2008 02:30PM SPH Crossroads 2695

Presenter:Tianle (Larry) Hu
Powerful multilocus tests of genetic association in the presence of gene-gene and gene-environment interactions.
    AJHG (2006) 79:1002-16. Chatterjee N, Kalaylioglu Z, Moslehi R, Peters U, Wacholder S.
URL:http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=1698705&blobtype=pdf

Monday, March 03, 2008 02:30PM SPH Crossroads 2695

Presenter:Liming Liang
On the use of general control samples for genome-wide association studies: genetic matching highlights causal variants.
    Am J Hum Genet. 2008 82:453-63, Luca D, Ringquist S, Klei L, Lee AB, Gieger C, Wichmann HE, Schreiber S, Krawczak M, Lu Y, Styche A, Devlin B, Roeder K, Trucco M.
URL:http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B8JDD-4RNJCF0-3&_user=99318&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000007678&_version=1&_urlVersion=0&_userid=99318&md5=ce67a6700094c8b40e297b071414bbb6

Monday, March 17, 2008 02:30PM SPH Crossroads 2695

Presenter:Bill Stewart
PennCNV: An integrated hidden Markov model designed for high-resolution copy number variation detection in whole-genome SNP genotyping data.
    Genome Res (2007) 17:1665 - 1674, Wang K, Li M, Hadley D, Liu R, Glessner J, Grant SF, Hakonarson H, Bucan M.
URL:http://www.genome.org/cgi/reprint/17/11/1665

Monday, March 31, 2008 03:00PM SPH Crossroads 2695

Presenter:Jun Ding
Pathway-Based Approaches for Analysis of Genomewide Association Studies
    AJHG (2007) 81:1278-1283; Wang K, Li M, Bucan M
URL:http://download.ajhg.org/AJHG/pdf/PIIS0002929707637756.pdf

Monday, April 21, 2008 02:30PM SPH Crossroads 2695

Presenter:Rui Xiao
Accommodating linkage disequilibrium in genetic-association analyses via ridge regression.
    Am J Hum Genet. (2008) 82:375-85; Malo N, Libiger O, Schork NJ.
URL:http://download.ajhg.org/AJHG/pdf/PIIS0002929708000918.pdf?intermediate=true

Monday, May 05, 2008 02:30PM SPH Crossroads 2690

Presenter:Ali Shojaie
Semiparametric regression of multidimensional genetic pathway data: least-squares kernel machines and linear mixed models.
    Biometrics (2007) 63:1079-88. Liu D, Lin X, Ghosh D.
URL:http://www.blackwell-synergy.com/doi/abs/10.1111/j.1541-0420.2007.00799.x

Thursday, June 26, 2008 03:00PM 2695 Crossroads SPH

Presenter:Kraig Stevenson
Rare structural variants disrupt multiple genes in neurodevelopmental pathways in schizophrenia.
    Science. 2008 320:539-43. Walsh T, McClellan JM, McCarthy SE, Addington AM, Pierce SB, Cooper GM, Nord AS, Kusenda M, Malhotra D, Bhandari A, Stray SM, Rippey CF, Roccanova P, Makarov V, Lakshmi B, Findling RL, Sikich L, Stromberg T, Merriman B, Gogtay N,
URL:http://www.sciencemag.org.proxy.lib.umich.edu/cgi/reprint/320/5875/539.pdf

Thursday, July 10, 2008 10:30AM SPH II 1152

Presenter:Tanya Teslovich
Strong association of de novo copy number mutations with sporadic schizophrenia.
    Nature Genetics. 2008 40:880-885. Xu B, Roos JL, Levy S, van Rensburg EJ, Gogos JA, Karayiorgou M.
URL:http://www.nature.com/ng/journal/v40/n7/pdf/ng.162.pdf

Thursday, July 24, 2008 10:30AM Crossroads 1680

Presenter:Matthew Flickinger
Phenotypically concordant and discordant monozygotic twins display different DNA copy-number-variation profiles
    Am J Hum Genet. (2008) 82:763-712008. Bruder CE, Piotrowski A, Gijsbers AA, Andersson R, Erickson S, de Sthl TD, Menzel U, Sandgren J, von Tell D, Poplawski A, Crowley M, Crasto C, Partridge EC, Tiwari H, Allison DB, Komorowski J, van Ommen GJ, Boomsma DI
URL:http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B8JDD-4RV1K19-1-G&_cdi=43612&_user=99318&_coverDate=03%2F03%2F2008&_sk=%23TOC%2343612%232008%23999179996%23682058%23FLA%23display%23Volume_82,_Issue_3,_Pages_535-804_(3_March_2008)%23tagged%23Volume%

Tuesday, August 05, 2008 03:00PM SPH I 3755

Presenter:Peng Zhang
Whole-genome association study of bipolar disorder.
    Mol Psychiatry. (2008) 13:558-69. Sklar P, Smoller JW, Fan J, Ferreira MA, Perlis RH, Chambert K, Nimgaonkar VL, McQueen MB, Faraone SV, Kirby A, de Bakker PI, Ogdie MN, Thase ME, Sachs GS, Todd-Brown K, Gabriel SB, Sougnez C, Gates C, Blumenstiel B, Defe
URL:http://www.nature.com/mp/journal/v13/n6/full/4002151a.html

Tuesday, August 26, 2008 04:00PM 2695 CR SPH

Presenter:Abby Woodroffe
Estimating coverage and power for genetic association studies using near-complete variation data
    Bhangale TR, Rieder MJ, Nickerson DA. Nat Genet. 2008 Jul;40(7):841-3
URL:http://www.nature.com/ng/journal/v40/n7/pdf/ng.180.pdf

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2006-2007

Monday, September 18, 2006 02:30PM 4034 Biostatistics Conference Rm. SPH II

Presenter:Bill Stewart
Efficiency and power in genetic association studies.
    de Bakker PI, Yelensky R, Pe'er I, Gabriel SB, Daly MJ, Altshuler D. (2005) Nat Genet 37:1217-23.
URL:http://www.nature.com/ng/journal/v37/n11/pdf/ng1669.pdf

Monday, October 02, 2006 02:30PM 5026 SPH II

Presenter:Janet Sinsheimer
HLA-B Maternal-Fetal Genotype Matching Increases Risk of Schizophrenia
    Christina G. S. Palmer, Hsin-Ju Hsieh, Elaine F. Reed, Jouko Lonnqvist, Leena Peltonen, J. Arthur Woodward, and Janet S. Sinsheimer, AJHG (2006) 79:710-715
URL:http://www.journals.uchicago.edu/AJHG/journal/issues/v79n4/43692/43692.web.pdf?erFrom=-6959867984537559934ASHG42887\r\n

Monday, October 23, 2006 02:30PM M3023, SPH II

Presenter:Discussion of ASHG Sessions
n/a
    na/
URL:http://genetics.faseb.org/genetics/ashg/annmeet/2006/call/pdf/2390%20Abstracts,%206-per-page.pdf

Monday, November 20, 2006 02:30PM M4318 SPH II

Presenter:Liming Liang
A Fast Method for Computing High-Significance Disease Association in Large Population-Based Studies
    Kimmel G, Shamir R, AJHG (2006) 79:481-492.
URL:http://www.journals.uchicago.edu/AJHG/journal/issues/v79n3/43735/43735.web.pdf

Monday, December 04, 2006 02:30PM M5026, SPH II

Presenter:Yun Li
Generalized Genomic Distance-Based Regression Methodology for Multilocus Association Analysis
    Jennifer Wessel and Nicholas Schork, AJHG (2006) 79:792-806
URL:http://www.journals.uchicago.edu/AJHG/journal/issues/v79n5/43606/43606.html

Monday, December 11, 2006 02:30PM 5026 SPH II

Presenter:Weihua Guan
Multipoint Linkage-Disequilibrium Mapping with Haplotype-Block Structure
    Maoxia Zheng and Mary Sara McPeek, AJHG (early online)
URL:http://www.journals.uchicago.edu/AJHG/journal/issues/v80n1/44004/44004.web.pdf

Wednesday, February 07, 2007 03:00PM 2690 SPH Crossroads

Presenter:Steve Qin
Inference of population structure under a Dirichlet process prior.
    Huelsenbeck JP, Andolfatto P., Genetics 2007 Jan 21; [Epub ahead of print]
URL:http://www.genetics.org/cgi/rapidpdf/genetics.106.061317v

Wednesday, February 21, 2007 03:00PM M5026 SPH II

Presenter:Sebastian Zoellner
Genome-wide detection of human copy number variations using high-density DNA oligonucleotide arrays
    Komura D, Shen F, Ishikawa S, Fitch KR, Chen W, Zhang J, Liu G, Ihara S, Nakamura H, Hurles ME, Lee C, Scherer SW, Jones KW, Shapero MH, Huang J, Aburatani H., Genome Res. (2006) 16:1575-84
URL:http://www.genome.org/cgi/content/full/16/12/1575?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=1&andorexacttitle=and&andorexacttitleabs=and&andorexactfulltext=and&searchid=1&FIRSTINDEX=0&sortspec=relevance&volume=16&firstpage=1575&resourcetype=HWCIT\r\n\r\n\r\

Wednesday, March 28, 2007 03:00PM 2690 SPH Crossroads

Presenter:Charles Ding
Leveraging the HapMap Correlation Structure in Association Studies
    Noah Zaitlen, Hyun Min Kang, Eleazar Eskin, and Eran Halperin; AJHG (2007) 80:683-691
URL:http://www.journals.uchicago.edu/AJHG/journal/issues/v80n4/44339/44339.web.pdf

Wednesday, April 04, 2007 03:00PM 2690 SPH Crossroads

Presenter:Jun Ding
Common genetic variants account for differences in gene expression among ethnic groups.
    Richard S Spielman, Laurel A Bastone, Joshua T Burdick, Michael Morley, Warren J Ewens, Vivian G Cheung; Nature Genetics (2007) 39:226-231
URL:http://www.nature.com.proxy.lib.umich.edu/ng/journal/v39/n2/pdf/ng1955.pdf

Thursday, May 24, 2007 03:00PM 2690 SPH Crossroads

Presenter:Rui Xiao
Relative impact of Nucleotide and Copy Number Variation on Gene Expression Phenotypes
    Stranger BE, Forrest MS, Dunning M, Ingle CE, Beazley C, Thorne N, Redon R, Bird CP, de Grassi A, Lee C, Tyler-Smith C, Carter N, Scherer SW, Tavare S, Deloukas P, Hurles ME, Dermitzakis ET
URL:http://www.sciencemag.org/cgi/content/full/315/5813/848

Thursday, June 14, 2007 03:00PM Crossroads 2690

Presenter:Laura Scott
Genetic Properties Influencing the Evolvability of Gene Expression.
    Science. 2007 May 24; [Epub ahead of print]; Landry CR, Lemos B, Rifkin SA, Dickinson WJ, Hartl DL.
URL:http://www.sciencemag.org/cgi/rapidpdf/1140247v1.pdf

Thursday, July 26, 2007 03:00PM SPH II 4117

Presenter:Vesela Gateva
Power of genome-wide association studies in the presence of interacting loci\r\n
    Genetic Epidiemiology, Published Online: 16 May 2007. Joseph Pickrell, Franoise Clerget-Darpoux, Catherine Bourgain
URL:http://www3.interscience.wiley.com/cgi-bin/fulltext/114262359/PDFSTART\r\n

Thursday, August 09, 2007 03:00PM Crossroads 2690

Presenter:Shyam Gopalakrishnan
Combining evidence of natural selection with association analysis increases power to detect malaria-resistance variants.
    AJHG (2007) 81:234-42. Ayodo G, Price AL, Keinan A, Ajwang A, Otieno MF, Orago AS, Patterson N, Reich D.
URL:http://www.journals.uchicago.edu.proxy.lib.umich.edu/AJHG/journal/issues/v81n2/44717/44717.web.pdf

Thursday, August 30, 2007 03:00PM Crossroads 2690

Presenter:Wei Chen
Genetic variation in putative regulatory loci controlling gene expression in breast cancer.
    Proc Natl Acad Sci U S A. 2006 103:7735-40. Kristensen VN, Edvardsen H, Tsalenko A, Nordgard SH, Sørlie T, Sharan R, Vailaya A, Ben-Dor A, Lønning PE, Lien S, Omholt S, Syvänen AC, Yakhini Z, Børresen-Dale AL.
URL:http://www.pnas.org/cgi/reprint/103/20/7735.pdf

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2005-2006

Monday, September 26, 2005 03:00PM 4034 SPH II Biostats Conference Rm.

Presenter:Michael Boehnke
High-resolution whole-genome association study of Parkinson disease
    e-published AJHG 77: 2005: DM Maraganore, M de Andrade, TG Lesnick, KJ Strain, MJ Farrer, WA Rooca, PVK Pant, KA Frazer, DR Cox DG Ballinger

Monday, October 17, 2005 03:00PM Biostatistics Conference Room

Presenter:Laura Scott
A whole-genome admixture scan finds a candidate locus for multiple sclerosis susceptibility.
    Reich D, Patterson N, Jager PL, McDonald GJ, Waliszewska A, Tandon A, Lincoln RR, Deloa C, Fruhan SA, Cabre P, Bera O, Semana G, Kelly MA, Francis DA, Ardlie K, Khan O, Cree BA, Hauser SL, Oksenberg JR, Hafler DA.
URL:http://www.nature.com/ng/journal/v37/n10/pdf/ng1646.pdf

Monday, October 31, 2005 03:00PM Biostatistics Conference Room

Presenter:Sebastian Zollner
A High-Resolution Survey of Deletion Polymorphisms in the Human Genome.
    Conrad D, Andrews D, Carter NP, Hurles ME, Pritchard JK
URL:http://www.nature.com/ng/journal/v38/n1/full/ng1697.html

Monday, November 14, 2005 03:00PM Biostatistics Conference Room

Presenter:Weihua Guan
Identifying interacting SNPs using Monte Carlo logic regression
    Genetic Epid 28: 157-170 (2005), C Kooperberg and I Ruczinski
URL:http://www3.interscience.wiley.com/cgi-bin/fulltext/109751891/PDFSTART

Monday, November 28, 2005 03:00PM Biostatistics Conference Room

Presenter:Steve Qin
GERBIL: Genotype resolution and block identification using likelihood.
    Kimmel G, Shamir R. PNAS (2005) 102:158-62
URL:http://www.pnas.org/cgi/reprint/102/1/158

Monday, December 12, 2005 03:00PM Biostatistics Conference Room

Presenter:Weimin Chen
Mapping determinants of human gene expression by regional and genome-wide association
    Vivian G. Cheung, Richard S. Spielman, Kathryn G. Ewens, Teresa M.Weber, Michael Morley and Joshua T. Burdick, Nature 437:1365-1369(2005)
URL:http://www.nature.com/nature/journal/v437/n7063/pdf/nature04244.pdf

Monday, January 09, 2006 04:00PM Biostatistics Conference Room

Presenter:Mike Boehnke
Using linkage genome scans to improve power of assocation in genome scans.
    K Roeder, S-A Bacanu, L. Wasserman, B Devlin

Monday, January 23, 2006 03:00PM Biostatistics Conference Room

Presenter:Bill Stewart
A Testing Framework for Identifying Susceptibility Genes in the Presence of Epistasis
    AJHG (2006) 78:15-27, Millstein J, Conti DV, Gilliland FD, Gauderman WJ.
URL:http://www.journals.uchicago.edu.proxy.lib.umich.edu/AJHG/journal/issues/v78n1/42737/42737.web.pdf

Monday, February 20, 2006 03:00PM M4034 SPH II (Biostatisitics Conference Room)

Presenter:Rui Xiao
Reduction of selection bias in genomewide studies by resampling.
    (2005) Genetic Epidemiology 28: 352-367, Sun, L. and Bull, S.B.
URL:http://www3.interscience.wiley.com.proxy.lib.umich.edu/cgi-bin/fulltext/110429188/PDFSTART

Monday, March 06, 2006 03:00PM M4034 SPH II

Presenter:Yun Li
A multimarker regression-based test of linkage for affected sib-pairs at two linked loci. \r\n
    Barber MJ, Todd JA, Cordell HJ; Genet Epidemiol. 2005 Dec 29; [Epub ahead of print]
URL:http://www3.interscience.wiley.com/cgi-bin/fulltext/112223278/PDFSTART

Monday, March 27, 2006 Biostatistics Conference Room

Presenter:Weihua Guan
The use of unphased multilocus genotype data in indirect association studies\r\n
    Genet Epidemiol (2004) 27:415-428,
URL:http://www3.interscience.wiley.com/cgi-bin/fulltext/109698099/PDFSTART

Monday, April 07, 2006 03:00PM M 5026 SPH II

Presenter:Maire-Helene Roy-Gagnon
Genetic association tests based on ranks (GATOR) for quantitative traits with and without censoring
    Genet Epidemiol30:248-258, Allen AS, Martin ER, Qin X, Li YJ.(2006)
URL:http://www3.interscience.wiley.com/cgi-bin/fulltext/112464366/PDFSTART

Monday, April 17, 2006 02:00PM M5026, SPH II

Presenter:Liming Liang
Multiple Testing in the Context of Haplotype Analysis Revisited: Application to Case-Control Data
    T. Becker, S. Cichon , E. Jonson and M. Knapp. Annals of Human Genetics (2005) 69:747-756,
URL:http://www.blackwell-synergy.com/doi/abs/10.1111/j.1529-8817.2005.00198.x

Wednesday, May 24, 2006 04:00PM Biostatistics Conference Room

Presenter:Laura Scott
Common deletion polymorphisms in the human genome.
    McCarroll SA, Hadnott TN, Perry GH, Sabeti PC, Zody MC, Barrett JC, Dallaire S, Gabriel SB, Lee C, Daly MJ, Altshuler DM; International HapMap Consortium. Nat Genet. (2006) 38:86-92
URL:http://www.nature.com/ng/journal/v38/n1/pdf/ng1696.pdf

Wednesday, June 14, 2006 04:00PM Biostatistics Conference Room

Presenter:Rui Xiao
"Optimal Two-Stage Genotyping Designs for Genome-Wide Association Scans"
    Hansong Wang,et al., Genetic Epidemiology 30: 356-368(2006)
URL:http://www3.interscience.wiley.com/cgi-bin/fulltext/112588119/PDFSTART\r\n

Wednesday, July 26, 2006 04:00PM Biostatistics Conference Room, M4034, SPH II

Presenter:Bill Stewart
Efficiency and power in genetic association studies.
    de Bakker PI, Yelensky R, Pe'er I, Gabriel SB, Daly MJ, Altshuler D. (2005) Nat Genet 37:1217-23.
URL:http://www.nature.com/ng/journal/v37/n11/pdf/ng1669.pdf

Top

2004-2005

Thursday, August 12, 2004 11:00AM SPH II 4141

Presenter:Weimin Chen
Genetic analysis of genome-wide variation in human gene expression.
    Morley M, Molony CM, Weber TM, Devlin JL, Ewens KG, Spielman RS, Cheung VG, published online Nature, 2004 July 21
URL:http://www.nature.com/cgi-taf/DynaPage.taf?file=/nature/journal/vaop/ncurrent/full/nature02797_fs.html&content_filetype=pdf

Wednesday, September 15, 2004 03:00PM SPH II, Biostats conference room

Presenter:Laura Scott
Two-stage designs for gene-disease association studies with sample size constraints.
    Satagopan JM, Venkatraman ES, Begg CB. Biometrics. 2004 Sep;60(3):589-97.
URL:http://www.blackwell-synergy.com/doi/full/10.1111/j.0006-341X.2004.00207.x?cookieSet=1

Wednesday, September 29, 2004 03:00PM SPH II 4034 (Biostats conference room)

Presenter:Laila Poisson
A powerful strategy to account for multiple testing in the context of haplotype analysis.
    Becker T and Knapp M, 2004, AJHG 75:561-570
URL:http://www.journals.uchicago.edu/AJHG/journal/issues/v75n4/41301/41301.web.pdf

Wednesday, October 20, 2004 03:00PM SPH II 4034 (Biostats conference room)

Presenter:Jen Poynter
Nonsense-mediated decay microarray analysis identifies mutations of EPHB2 in human prostate cancer.
    Huusko et al. (2004) Nature Genetics 36:979-983.
URL:http://www.nature.com/cgi-taf/DynaPage.taf?file=/ng/journal/v36/n9/full/ng1408.h

Wednesday, November 10, 2004 03:00PM SPH II RM 5064 ( NOTE ROOM CHANGE!)

Presenter:ASHG Discussion
All are welcome to participate whether or not you attended the ASHG meeting. We will talk about interesting posters, talks or ideas that arose at the ASHG meeting. We will likely have each person who attended describe one thing that interested them to sti
    ASHG

Wednesday, December 01, 2004 03:00PM 5064 SPH II (note room change)

Presenter:Margit Burmeister
Genetic dissection of a behavioral quantitative trait locus shows that Rgs2 modulates anxiety in mice. \r\n
    Yalcin B, Willis-Owen SAG, Fullerton J, Meesaq A, Deacon RM, Rawlins
URL:http://www.nature.com/cgi-taf/DynaPage.taf?file=/ng/journal/v36/n11/full/ng1450.html&filetype=pdf

Wednesday, January 26, 2005 03:00PM Biostatistics Conference Room

Presenter:Karen Conneely
Truncated product method for combining P-values.
    Zaykin DV, Zhivotovsky LA, Westfall PH, Weir BS
URL:http://www3.interscience.wiley.com/cgi-bin/fulltext/89013846/PDFSTART

Friday, February 18, 2005 03:00PM M4034 SPH II (Biostatistics Conference Room)

Presenter:Laura Scott
Detecting genetic association in case-control studies using\r\nsimilarity-based association tests. \r\n\r\n\r\n
    Zhang, S., Kidd, K.K., Zhao, H. (2002) Statistica Sinica 12:337-359
URL:http://www.stat.sinica.edu.tw/statistica/

Friday, March 11, 2005 03:00PM Biostatistics Conference Room

Presenter:Laura Rozek
The optimal measure of linkage disequilibrium reduces error in association mapping of affection status.
    N. Maniatis, N.E. Morton, J. Gibson, C.-F. Xu, L.K. Hosking, and A.
URL:http://hmg.oupjournals.org/cgi/reprint/14/1/145

Friday, April 01, 2005 03:00PM M3024 SPH II

Presenter:Laila Poisson
Genetic association analysis using data from triads and unrelated subjects. \r\n
    Epstein MP, Veal CD, Trembath RC, Barker JN, Li C, Satten GA.
URL:http://www.journals.uchicago.eu/AJHG/journal/issues/v76n4/41906/41906.web.pdf

Wednesday, April 13, 2005 03:00PM Biostatistics Conference Room

Presenter:Viktoriya Strumba
Complex trait analysis of gene expression uncovers polygenic and pleiotropic networks that modulate nervous system function.
    Chesler EJ, Lu L, Shou S, Qu Y, Gu J, Wang J, Hsu HC, Mountz JD, Baldwin
URL:http://www.nature.com/ng/journal/v37/n3/pdf/ng1518.pdf

Wednesday, May 04, 2005 03:00PM M 3024 SPH II

Presenter:Andrew Skol
Genome-wide strategies for detecting multiple loci that influence complex diseases.
    Marchini J, Donnelly P, Cardon LR.
URL:http://www.nature.com/ng/journal/v37/n4/pdf/ng1537.pdf

Wednesday, May 25, 2005 03:00PM M3024 SPH II

Presenter:Jen Poynter
Fine Scale Structural Variation of the Human Genome.
    Tuzun E, Sharp AJ, Bailey JA, Kaul R, Morrison VA, Pertz LM, Haugen E, Hayden H, Albertson D, Pinkel D, Olson MV, Eichler EE
URL:http://www.nature.com/ng/journal/vaop/ncurrent/pdf/ng1562.pdf

Wednesday, June 08, 2005 03:00PM Biostatistics Conference Room

Presenter:Laura Rozek
Rational Inferences about Departures from Hardy-Weinberg Equilibrium.
    Wittke-Thompson JK, Pluzhnikov A, Cox NJ
URL:http://www.journals.uchicago.edu/AJHG/journal/issues/v76n6/42151/42151.web.pdf

Wednesday, June 22, 2005 03:00PM Biostatistics Conference Room

Presenter:Weimin Chen
A powerful and robust method for mapping quantitative trait loci in general pedigrees
    Diao G and Lin DY
URL:http://www.journals.uchicago.edu/AJHG/journal/issues/v77n1/42246/42246.web.pdf

Wednesday, July 06, 2005 03:00PM Biostatistics Conference Room

Presenter:Weihua Guan
Exact and Approximate Stepdown Methods for Multiple Hypothesis Testing
    JP Romano, M Wolf
URL:http://proquest.umi.com/pqdlink?index=0&did=807923151&SrchMode=1&sid=1&Fmt=6&VInst=PROD&VType=PQD&RQT=309&VName=PQD&TS=1120078700&clientId=17822

Wednesday, July 20, 2005 03:00PM M3024 SPH II

Presenter:Cristen Willer
A high-resolution map of active promoters in the human genome
    Tae Hoon Kim, Leah O. Barrera, Ming Zheng, Chunxu Qu, Michael A. Singer, Todd A. Richmond, Yingnian Wu, Roland D. Green, Bing Ren
URL:http://www.nature.com/cgi-taf/DynaPage.taf?file=/nature/journal/vaop/ncurrent/full/nature03877.html&filetype=pdf

Wednesday, August 03, 2005 03:00PM (actually 3:30-4:30pm) Biostatistics Conference Room

Presenter:Karen Conneely
Genomic screening and replication using the same data set in family-based association testing.
    Nat Genet (2005) 37:683-691. Van Steen K, McQueen MB, Herbert A, Raby B, Lyon H, Demeo DL, Murphy A, Su J, Datta S, Rosenow C, Christman M, Silverman EK, Laird NM, Weiss ST, Lange C
URL:http://www.nature.com.proxy.lib.umich.edu/ng/journal/v37/n7/pdf/ng1582.pdf\r\n

Wednesday, August 17, 2005 03:00PM (actually 3:30-4:30pm) Biostatistics Conference Room

Presenter:Steve Qin
TBD
    TBD
URL:http://TBD

Wednesday, August 31, 2005 03:00PM (actually 3:30-4:30pm) Biostatistics Conference Room

Presenter:Mingyao Li
"Multiple Testing in the Context of Haplotype Analysis Revisited: Application to Case-Control Data"
    T. Becker, S. Cichon, E. Jonson and M. Knapp; Annals of Human Genetics 2005: advance online publication
URL:http://www.blackwell-synergy.com/toc/ahg/0/0

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2003-2004

September 30, 2003

Presenter:Laura Scott, Biostatistics
Are we there yet? Deciding when one has demonstrated specific genetic causation in complex diseases and quantitative traits.
    GP Page, V George, RC Go PZ Page, DB Allison, AJHG 2003 73:711-719
URL:http://www.journals.uchicago.edu/AJHG/journal/issues/v73n4/40440/40440.web.pdf

October 28, 2003

Presenter:Jen Poynter, Epidemiology
The gene encoding phosphodiesterase 4D confers risk of ischemic stroke.
    S Gretarsdottir, G Thorleifsson, S T Reynisdottir, A Manolescu, S Jonsdottir, T Jonsdottir, T Gudmundsdottir, et al. Nature Genetics 2003 35:131-138.
URL:http://www.nature.com/cgi-taf/DynaPage.taf?file=/ng/journal/v35/n2/full/ng1245.html&filetype=pdf

November 11, 2003

Presenter:Laila Poisson, Biostatistics
Accounting for linkage in family-based tests of association with missing parental genotypes.
    Martin ER, Bass MP, Hauser ER, Kaplan NL. ASHG 2003 73:1016-26
URL:http://www.journals.uchicago.edu/AJHG/journal/issues/v73n5/40122/40122.web.pdf

November 25, 2003

Presenter:Andrew Skol, Biostatistics
Genomewide Distribution of High-Frequency, Completely Mismatching SNP Haplotype Pairs Observed To Be Common across Human Populations.
    Jinghui Zhang, William L. Rowe, Andrew G. Clark, and Kenneth H. Buetow. AJHG 2003 73:1073-1081.
URL:http://80-www.journals.uchicago.edu.proxy.lib.umich.edu/AJHG/journal/issues/v73n5/40222/40222.web.pdf

December 10, 2003

Presenter:Laura Scott, Biostatistics
Natural variation in human gene expression assessed in lymphoblastoid cells. AND Genetic Dissection of Transcriptional Regulation in Budding Yeast.
    Cheung VG, Conlin LK, Weber TM, Arcaro M, Jen KY, Morley M, Spielman RS. Nat Genet 2003 33:422-5. AND Brem RB, Yvert G Clinton R, Kruglyak L. Science 2002 296: 752-755.
URL:http://www.nature.com/cgi-taf/DynaPage.taf?file=/ng/journal/v33/n3/full/ng1094.html&filetype=pdf AND http://www.sciencemag.org/cgi/reprint/296/5568/752.pdf

January 29, 2004

Presenter:Laura Scott, Biostatistics
Selecting a maximally informative set of single-nucleotide polymorphisms for association analyses using linkage disequalibrium
    Carlson CS, Eberle MA, Rieder MJ, Yi Q, Kruglyak L, Nickerson DA. AJHG 2003 74:106-120.
URL:http://www.journals.uchicago.edu/AJHG/journal/issues/v74n1/40547/40547.web.pdf

Wednesday, February 02, 2004 03:00PM Biostatistics Conference Room

Presenter:Weimin Chen
Exhaustive allelic transmission disequilibrium tests as a new approach to genome-wide association studies. \r\n
    Shin Lin, Aravinda Chakravarti, David J Cutler
URL:http://www.nature.com/cgi-taf/DynaPage.taf?file=/ng/journal/v36/n11/full/ng1457.html&filetype=pdf

February 12, 2004

Presenter:Karen Conneely, Biostatistics
Evidence for extensive transmission distortion in the human genome.
    Zollner S, Wen X, Hanchard NA, Herbert MA, Ober C, Pritchard JK. 2003 AJHG 74:62-72.
URL:http://www.journals.uchicago.edu/AJHG/journal/issues/v74n1/40208/40208.web.pdf

February 26, 2004

Presenter:Mike Boehnke, Biostatistics
Matching Strategies for Genetic Association Studies in Structured Populations.
    David A. Hinds, Renee P. Stokowski, Nila Patil, Karel Konvicka, David Kershenobich, David R. Cox, and Dennis G. Ballinger. AJHG 2004 74:317-325.
URL:http://www.journals.uchicago.edu/AJHG/journal/issues/v74n2/40522/40522.web.pdf

March 11, 2004

Presenter:Steve Qin, Biostatistics
Backward Haplotype Transmission Association (BHTA) algorithm - a fast multiple-marker screening method.
    Lo SH, Zheng T. Humum Heredity 2002;53:197-215.

April 01, 2004

Presenter:Laura Rozek, Epidemiology
Genomic convergence: identifying candidate genes for Parkinson's disease by combining serial analysis of gene expression and genetic linkage.
    Hauser MA, Li YJ, Takeuchi S, Walters R, Noureddine M, Maready M, Darden T, Hulette C, Martin E, Hauser E, Xu H, Schmechel D, Stenger JE, Dietrich F, Vance J. Hum Mol Genet 2003 12:671-7.
URL:http://hmg.oupjournals.org/cgi/reprint/12/6/671.pdf

April 15, 2004

Presenter:Mingyao Li, Biostatistics
Positional Cloning by Linkage Disequilibrium.
    Maniatis N, Collins A, Gibson J, Zhang W, Tapper W, Morton NE. AJHG 74: e-publication, 2004.
URL:http://www.journals.uchicago.edu/AJHG/journal/issues/v74n5/40509/40509.web.pdf

May 06, 2004

Presenter:Andrew Skol, Biostatistics
The Fine-Scale Structure of Recombination Rate Variation in the Human Genome.
    Gilean A. T. McVean, Simon R. Myers, Sarah Hunt, Panos Deloukas, David R. Bentley, Peter Donnelly. Science 304:581-584.
URL:http://www.sciencemag.org/cgi/reprint/304/5670/581.pdf

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2002-2003

September 09, 2002

Presenter:Debashis Ghosh, Biostatistics
Assessing gene significance from cDNA microarray expression data via mixed models.
    Wolfinger RD et al. Journal of Computational Biology, 8(6):625-37

September 23, 2002

Presenter:Jeremy Taylor, Biostatistics
Use of proteomic patterns in serum to identify ovarian cancer.
    Petricoin EF, Ardekani AM, Kitt BA, Levine PJ, Fusaro VA, Steinberg SM, Mills GB, Simone C

October 07, 2002

Presenter:Tom Blackwell, Bioinformatics
Variation in gene expression within and among natural populations.
    Oleksiak MF, Churchill GA, Crawford DL.
Nature Genetics 2002 3 Sept 32(2):261-6

October 21, 2002

Presenter:Kerby Shedden and Gus Rossania, Statistics
Associations between gene expression and chemosensitivity: a link between exosome-related genes and anticancer drug resistance.

November 04, 2002

Presenter:Rich Miller, Pathology
Gene expression studies of aging: Triumph and tragedy from the front lines.

November 13, 2002

Presenter:Laura Scott, Biostatistics
Haplotype inference in random population samples.
    Lin S, Cutler DJ, Zwick E, Chakravarti A.

November 18, 2002

Presenter:Bin Nan, Biostatistics
Transitive functional annotation by shortest-path analysis of gene expression data.
    Zhou X, et al. PNAS, 99(20):12783-12788

December 02, 2002

Presenter:Wei Chen, Biostatistics
TDifferential expression methods in gene expression studies.

December 04, 2002

Presenter:Mingyao Li, Biostatistics
A robust identity-by-descent procedure using affected sib pairs: Multipoint mapping for complex diseases.
    Liang K-Y, Chiu Y-F, Beaty TH. Human Heridity 51:64-78, 2001.

December 11, 2002

Presenter:Andrew Skol, Biostatistics
Choosing a set of haplotype tagging SNPs from a larger set of diallelic loci.
    Clayton D.
URL:http://www-gene.cimr.cam.ac.uk/clayton/software/stata/htSNP/htsnp.pdf

December 18, 2002

Presenter:Tasha Fingerlin, Epidemiology
Detecting recent positive selection in the human genome from haplotype structure.
    Sabeti, et al. Nature (Online publication October 9, 2002)

January 13, 2003

Presenter:Laura Rozek, Epidemiology
Counting alleles reveals a connection between chromosome 18q and vascular invasion.
    Zhou W, et al. Nat Biotechnol 19:78-81 2001

January 13, 2003

Presenter:Debashis Ghosh, Biostatistics
A molecular signature of metastasis in primary solid tumors..
    Ramaswamy S, Ross KN, Lander ES, Golub TR. Nat Genet. 2003 Jan;33(1):10-1

January 27, 2003

Presenter:Unknown
A dynamic programming algorithm for haplotype block partitioning.
    Zhang K, Deng M, Chen T, Waterman MS, Sun F. PNAS 99:7335-7339, 2002

January 27, 2003

Presenter:Lixin Zhang, Biostatistics
Library on a slide: Creating collection microarrays for assessing genetic diversity of bacteria species.

February 03, 2003

Presenter:Laura Scott, Biostatistics
Heirarchical modeling of linkage disequilibrium: Genetic structure and spatial relations.
    Conti DV, Witte JS. NAJHG 72:351-363 2003.

February 17, 2003

Presenter:Debashis Ghosh, Biostatistics
Robustness of inference on measured covariates to misspecification of genetic random effects in family studies.
    Pfeiffer RM, et al. Genetic Epidemiology 24:14-23 2003

February 24, 2003

Presenter:Kerby Shedden, Statistics
Genome-wide coexpression dynamics: Theory and application.
    Li K-C. PNAS, 99(26):16875-16880, Dec 24, 2002

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