Departments of Anesthesiology and Biostatistics | University of Michigan
Trait code Trait Cohort Method GWAS source # SNPs P value R² / pseudo-R² Brier AAUC Top 1% effect Flags Links
174.1 Breast cancer [female]
Overall
UKB PRS-CS Michailidou K et al. 2018 1120410 2.1e-364 0.056 0.0805 0.652
0.645-0.658
4.38
OR 95% CI: 3.79-5.07
Binary nominal
174.1 Breast cancer [female]
Overall
UKB lassosum Michailidou K et al. 2018 286144 2.91e-325 0.0514 0.0807 0.643
0.637-0.65
4.02
OR 95% CI: 3.46-4.67
Binary nominal
174.1 Breast cancer [female]
ER positive
UKB PRS-CS Michailidou K et al. 2018 1120410 1.12e-308 0.0497 0.0809 0.64
0.634-0.647
3.64
OR 95% CI: 3.12-4.25
Binary nominal
185 Cancer of prostate
Prostate cancer
UKB PRS-CS Schumacher FR et al. 2019 1120596 1.15e-308 0.0928 0.0791 0.705
0.695-0.715
5.58
OR 95% CI: 4.58-6.78
Binary nominal
185 Cancer of prostate
Prostate cancer
UKB lassosum Schumacher FR et al. 2019 178259 1.2e-292 0.0915 0.0794 0.699
0.69-0.71
5.88
OR 95% CI: 4.85-7.14
Binary nominal
174.1 Breast cancer [female]
ER positive
UKB lassosum Michailidou K et al. 2018 148560 1.4e-274 0.0449 0.0811 0.631
0.624-0.638
3.86
OR 95% CI: 3.31-4.5
Binary nominal
174.1 Breast cancer [female]
Overall
UKB Fixed threshold (5e-06) Michailidou K et al. 2018 712 1.5e-271 0.0437 0.0811 0.628
0.62-0.635
3.69
OR 95% CI: 3.16-4.31
Binary nominal
174.1 Breast cancer [female]
Overall
UKB P&T Michailidou K et al. 2018 1682 2.5e-270 0.0455 0.0811 0.63
0.623-0.637
3.32
OR 95% CI: 2.83-3.9
Binary nominal
174.1 Breast cancer [female]
Overall
UKB Fixed threshold (5e-05) Michailidou K et al. 2018 1307 7.1e-265 0.0443 0.0812 0.627
0.62-0.634
3.49
OR 95% CI: 2.98-4.08
Binary nominal
185 Cancer of prostate
Prostate cancer
UKB Fixed threshold (5e-05) Schumacher FR et al. 2019 1223 2.9e-263 0.0793 0.0799 0.688
0.678-0.698
5.51
OR 95% CI: 4.52-6.71
Binary nominal
185 Cancer of prostate
Prostate cancer
UKB P&T Schumacher FR et al. 2019 1023 6.7e-263 0.0802 0.0799 0.687
0.678-0.698
5.88
OR 95% CI: 4.84-7.13
Binary nominal
174.1 Breast cancer [female]
Overall
UKB Fixed threshold (5e-07) Michailidou K et al. 2018 464 2.3e-260 0.0434 0.0812 0.626
0.618-0.633
3.81
OR 95% CI: 3.27-4.44
Binary nominal
185 Cancer of prostate
Prostate cancer
UKB Fixed threshold (5e-06) Schumacher FR et al. 2019 691 3.1e-257 0.0772 0.0801 0.686
0.676-0.696
5.01
OR 95% CI: 4.1-6.14
Binary nominal
185 Cancer of prostate
Prostate cancer
UKB Fixed threshold (5e-07) Schumacher FR et al. 2019 492 5.8e-250 0.076 0.0802 0.683
0.674-0.693
4.81
OR 95% CI: 3.92-5.91
Binary nominal
185 Cancer of prostate
Prostate cancer
UKB GWAS Hits Schumacher FR et al. 2019 377 8.8e-246 0.0746 0.0803 0.681
0.671-0.692
4.85
OR 95% CI: 3.95-5.95
Binary nominal
174.1 Breast cancer [female]
Overall
UKB GWAS Hits Michailidou K et al. 2018 334 2.5e-245 0.0409 0.0813 0.622
0.615-0.63
3.69
OR 95% CI: 3.16-4.31
Binary nominal
174.1 Breast cancer [female]
Overall
UKB PRS-CS Michailidou K et al. 2018 1116546 5.8e-243 0.0371 0.0813 0.623
0.615-0.63
3.54
OR 95% CI: 3.02-4.14
Binary nominal
185 Cancer of prostate
Prostate cancer
UKB Fixed threshold (5e-09) Schumacher FR et al. 2019 293 2.2e-239 0.0711 0.0804 0.678
0.668-0.688
4.51
OR 95% CI: 3.66-5.56
Binary nominal
174.1 Breast cancer [female]
Overall
UKB Fixed threshold (5e-09) Michailidou K et al. 2018 264 1.4e-236 0.039 0.0813 0.62
0.612-0.627
3.28
OR 95% CI: 2.79-3.86
Binary nominal
174.1 Breast cancer [female]
ER positive
UKB P&T Michailidou K et al. 2018 747 1.1e-235 0.0394 0.0814 0.621
0.614-0.628
3.36
OR 95% CI: 2.87-3.95
Binary nominal
174.1 Breast cancer [female]
ER positive
UKB Fixed threshold (5e-05) Michailidou K et al. 2018 950 6.4e-226 0.0385 0.0814 0.617
0.61-0.625
3.47
OR 95% CI: 2.96-4.06
Binary nominal
174.1 Breast cancer [female]
ER positive
UKB Fixed threshold (5e-06) Michailidou K et al. 2018 495 2.2e-225 0.0389 0.0814 0.617
0.61-0.625
3.06
OR 95% CI: 2.6-3.61
Binary nominal
174.1 Breast cancer [female]
Overall
UKB lassosum Michailidou K et al. 2018 7118 4.8e-220 0.037 0.0814 0.615
0.607-0.622
3.55
OR 95% CI: 3.04-4.16
Binary nominal
174.1 Breast cancer [female]
ER positive
UKB Fixed threshold (5e-07) Michailidou K et al. 2018 343 3.1e-218 0.0376 0.0815 0.615
0.607-0.622
3.01
OR 95% CI: 2.55-3.56
Binary nominal
174.1 Breast cancer [female]
ER positive
UKB GWAS Hits Michailidou K et al. 2018 257 1.8e-212 0.0361 0.0815 0.613
0.606-0.621
2.71
OR 95% CI: 2.28-3.23
Binary nominal
174.1 Breast cancer [female]
ER positive
UKB PRS-CS Michailidou K et al. 2018 1116495 3.3e-205 0.0309 0.0816 0.614
0.607-0.62
2.98
OR 95% CI: 2.52-3.52
Binary nominal
172.21 Basal cell carcinoma
Cancer code, self-reported: basal cell carcinoma (UKB GWAS (PHESANT))
UKB Fixed threshold (5e-05) GWAS Catalog (2019-05-03) 32 5e-201 0.0295 0.0812 0.618
0.611-0.626
2.95
OR 95% CI: 2.46-3.53
Binary nominal
172.21 Basal cell carcinoma
Cancer code, self-reported: basal cell carcinoma (UKB GWAS (PHESANT))
UKB Fixed threshold (5e-06) GWAS Catalog (2019-05-03) 32 5e-201 0.0295 0.0812 0.618
0.611-0.626
2.95
OR 95% CI: 2.46-3.53
Binary nominal
174.1 Breast cancer [female]
ER positive
UKB Fixed threshold (5e-09) Michailidou K et al. 2018 210 1.6e-200 0.0339 0.0816 0.61
0.603-0.617
2.7
OR 95% CI: 2.27-3.21
Binary nominal
172.21 Basal cell carcinoma
Cancer code, self-reported: basal cell carcinoma (UKB GWAS (PHESANT))
UKB Fixed threshold (5e-07) GWAS Catalog (2019-05-03) 31 1.2e-196 0.0291 0.0812 0.617
0.61-0.625
3.03
OR 95% CI: 2.53-3.62
Binary nominal
172.21 Basal cell carcinoma
Cancer code, self-reported: basal cell carcinoma (UKB GWAS (PHESANT))
UKB GWAS Hits GWAS Catalog (2019-05-03) 30 8.6e-196 0.0287 0.0813 0.617
0.609-0.625
3.11
OR 95% CI: 2.6-3.71
Binary nominal
174.1 Breast cancer [female]
ER positive
UKB lassosum Michailidou K et al. 2018 12277 1.3e-194 0.0339 0.0816 0.608
0.601-0.615
3
OR 95% CI: 2.54-3.54
Binary nominal
172.21 Basal cell carcinoma
Cancer code, self-reported: basal cell carcinoma (UKB GWAS (PHESANT))
UKB Fixed threshold (5e-09) GWAS Catalog (2019-05-03) 24 2.3e-191 0.0299 0.0813 0.615
0.608-0.623
3.05
OR 95% CI: 2.55-3.64
Binary nominal
172.21 Basal cell carcinoma
Cancer code, self-reported: basal cell carcinoma (UKB GWAS (PHESANT))
UKB P&T GWAS Catalog (2019-05-03) 24 2.3e-191 0.0299 0.0813 0.615
0.608-0.623
3.05
OR 95% CI: 2.55-3.64
Binary nominal
185 Cancer of prostate
Prostate cancer;Prostate cancer (early onset)
UKB P&T GWAS Catalog (2019-05-03) 118 6.6e-186 0.0588 0.0813 0.653
0.643-0.663
4.34
OR 95% CI: 3.51-5.37
Binary nominal
172.21 Basal cell carcinoma
Cancer code, self-reported: basal cell carcinoma (UKB GWAS (PHESANT))
UKB Fixed threshold (5e-05) Chahal HS et al. 2018 28 2.1e-185 0.0289 0.0813 0.611
0.604-0.619
2.8
OR 95% CI: 2.33-3.36
Binary nominal
172.21 Basal cell carcinoma
Cancer code, self-reported: basal cell carcinoma (UKB GWAS (PHESANT))
UKB Fixed threshold (5e-06) Chahal HS et al. 2018 28 2.1e-185 0.0289 0.0813 0.611
0.604-0.619
2.8
OR 95% CI: 2.33-3.36
Binary nominal
172.21 Basal cell carcinoma
Cancer code, self-reported: basal cell carcinoma (UKB GWAS (PHESANT))
UKB Fixed threshold (5e-07) Chahal HS et al. 2018 28 2.1e-185 0.0289 0.0813 0.611
0.604-0.619
2.8
OR 95% CI: 2.33-3.36
Binary nominal
172.21 Basal cell carcinoma
Cancer code, self-reported: basal cell carcinoma (UKB GWAS (PHESANT))
UKB GWAS Hits Chahal HS et al. 2018 28 2.1e-185 0.0289 0.0813 0.611
0.604-0.619
2.8
OR 95% CI: 2.33-3.36
Binary nominal
172.21 Basal cell carcinoma
Cancer code, self-reported: basal cell carcinoma (UKB GWAS (PHESANT))
UKB P&T Chahal HS et al. 2018 28 2.1e-185 0.0289 0.0813 0.611
0.604-0.619
2.8
OR 95% CI: 2.33-3.36
Binary nominal
185 Cancer of prostate
Prostate cancer;Prostate cancer (early onset)
UKB GWAS Hits GWAS Catalog (2019-05-03) 117 5.5e-185 0.0585 0.0813 0.653
0.642-0.662
4.31
OR 95% CI: 3.48-5.33
Binary nominal
185 Cancer of prostate
Prostate cancer;Prostate cancer (early onset)
UKB Fixed threshold (5e-05) GWAS Catalog (2019-05-03) 124 6.1e-181 0.0572 0.0813 0.65
0.64-0.661
3.8
OR 95% CI: 3.05-4.75
Binary nominal
185 Cancer of prostate
Prostate cancer;Prostate cancer (early onset)
UKB Fixed threshold (5e-06) GWAS Catalog (2019-05-03) 124 6.1e-181 0.0572 0.0813 0.65
0.64-0.661
3.8
OR 95% CI: 3.05-4.75
Binary nominal
185 Cancer of prostate
Prostate cancer;Prostate cancer (early onset)
UKB Fixed threshold (5e-07) GWAS Catalog (2019-05-03) 123 7.5e-181 0.0571 0.0813 0.65
0.64-0.66
3.77
OR 95% CI: 3.02-4.7
Binary nominal
185 Cancer of prostate
Prostate cancer;Prostate cancer (early onset)
UKB Fixed threshold (5e-09) GWAS Catalog (2019-05-03) 86 1e-178 0.0578 0.0813 0.649
0.638-0.659
4.3
OR 95% CI: 3.48-5.32
Binary nominal
174.1 Breast cancer [female]
Overall
UKB Fixed threshold (5e-07) Michailidou K et al. 2018 154 6.6e-176 0.0296 0.0818 0.603
0.595-0.61
2.65
OR 95% CI: 2.22-3.15
Binary nominal
174.1 Breast cancer [female]
Overall
UKB Fixed threshold (5e-06) Michailidou K et al. 2018 246 4.1e-175 0.0291 0.0817 0.603
0.595-0.61
2.87
OR 95% CI: 2.43-3.4
Binary nominal
174.1 Breast cancer [female]
Overall
UKB P&T Michailidou K et al. 2018 85 9.6e-173 0.0306 0.0818 0.602
0.594-0.609
2.78
OR 95% CI: 2.34-3.3
Binary nominal
174.1 Breast cancer [female]
Overall
UKB GWAS Hits Michailidou K et al. 2018 110 3.8e-170 0.0299 0.0818 0.601
0.594-0.608
2.5
OR 95% CI: 2.09-2.99
Binary nominal
174.1 Breast cancer [female]
ER positive
UKB P&T Michailidou K et al. 2018 174 3.6e-169 0.0287 0.0818 0.6
0.593-0.608
2.92
OR 95% CI: 2.47-3.46
Binary nominal
174.1 Breast cancer [female]
Overall
UKB Fixed threshold (5e-09) Michailidou K et al. 2018 77 2e-168 0.0299 0.0818 0.6
0.593-0.607
2.58
OR 95% CI: 2.16-3.08
Binary nominal
174.1 Breast cancer [female]
ER positive
UKB Fixed threshold (5e-06) Michailidou K et al. 2018 185 6.6e-168 0.0285 0.0818 0.6
0.593-0.608
2.74
OR 95% CI: 2.31-3.26
Binary nominal
172.21 Basal cell carcinoma
Cancer code, self-reported: basal cell carcinoma (UKB GWAS (PHESANT))
UKB Fixed threshold (5e-09) Chahal HS et al. 2018 22 1.2e-165 0.0273 0.0815 0.604
0.597-0.612
2.68
OR 95% CI: 2.23-3.23
Binary nominal
174.1 Breast cancer [female]
ER positive
UKB Fixed threshold (5e-07) Michailidou K et al. 2018 113 2.7e-162 0.0272 0.0818 0.597
0.59-0.604
2.71
OR 95% CI: 2.28-3.22
Binary nominal
174.1 Breast cancer [female]
Overall
UKB Fixed threshold (5e-05) Michailidou K et al. 2018 534 3e-162 0.0259 0.0818 0.6
0.593-0.608
2.86
OR 95% CI: 2.41-3.39
Binary nominal
174.1 Breast cancer [female]
ER positive
UKB GWAS Hits Michailidou K et al. 2018 86 1.1e-157 0.0277 0.0819 0.597
0.59-0.604
2.68
OR 95% CI: 2.25-3.19
Binary nominal
174.1 Breast cancer [female]
Breast cancer;Breast cancer (estrogen-receptor negative);Breast Cancer in BRCA1 mutation carriers;Breast cancer in BRCA2 mutation carriers
UKB P&T GWAS Catalog (2019-05-03) 79 5.7e-155 0.028 0.0819 0.598
0.59-0.605
2.68
OR 95% CI: 2.25-3.18
Binary nominal
174.1 Breast cancer [female]
ER positive
UKB Fixed threshold (5e-05) Michailidou K et al. 2018 423 1.5e-150 0.0235 0.0819 0.596
0.589-0.603
2.49
OR 95% CI: 2.08-2.98
Binary nominal
174.1 Breast cancer [female]
ER positive
UKB Fixed threshold (5e-09) Michailidou K et al. 2018 63 6e-150 0.0273 0.0819 0.593
0.586-0.6
2.76
OR 95% CI: 2.33-3.28
Binary nominal
174.1 Breast cancer [female]
Breast cancer;Breast cancer (estrogen-receptor negative);Breast Cancer in BRCA1 mutation carriers;Breast cancer in BRCA2 mutation carriers
UKB Fixed threshold (5e-09) GWAS Catalog (2019-05-03) 64 1.2e-146 0.0255 0.0819 0.595
0.588-0.602
2.44
OR 95% CI: 2.04-2.92
Binary nominal
174.1 Breast cancer [female]
Breast cancer;Breast cancer (estrogen-receptor negative);Breast Cancer in BRCA1 mutation carriers;Breast cancer in BRCA2 mutation carriers
UKB Fixed threshold (5e-07) GWAS Catalog (2019-05-03) 93 1.7e-144 0.0249 0.0819 0.594
0.586-0.601
2.58
OR 95% CI: 2.16-3.08
Binary nominal
174.1 Breast cancer [female]
Breast cancer;Breast cancer (estrogen-receptor negative);Breast Cancer in BRCA1 mutation carriers;Breast cancer in BRCA2 mutation carriers
UKB GWAS Hits GWAS Catalog (2019-05-03) 86 3.9e-139 0.0245 0.082 0.592
0.585-0.6
2.58
OR 95% CI: 2.16-3.07
Binary nominal
174.1 Breast cancer [female]
Breast cancer;Breast cancer (estrogen-receptor negative);Breast Cancer in BRCA1 mutation carriers;Breast cancer in BRCA2 mutation carriers
UKB Fixed threshold (5e-06) GWAS Catalog (2019-05-03) 102 6.3e-132 0.023 0.082 0.589
0.582-0.597
2.26
OR 95% CI: 1.88-2.72
Binary nominal
174.1 Breast cancer [female]
Breast cancer;Breast cancer (estrogen-receptor negative);Breast Cancer in BRCA1 mutation carriers;Breast cancer in BRCA2 mutation carriers
UKB Fixed threshold (5e-05) GWAS Catalog (2019-05-03) 105 2.3e-125 0.0212 0.0821 0.586
0.579-0.594
2.24
OR 95% CI: 1.86-2.7
Binary nominal
174.1 Breast cancer [female]
ER negative
UKB PRS-CS Michailidou K et al. 2018 1120410 6e-101 0.0128 0.0822 0.579
0.572-0.586
2.34
OR 95% CI: 1.95-2.82
Binary nominal
174.1 Breast cancer [female]
ER negative
UKB lassosum Michailidou K et al. 2018 41744 3e-98 0.013 0.0822 0.576
0.568-0.583
2.25
OR 95% CI: 1.86-2.71
Binary nominal
172.22 Squamous cell carcinoma
Squamous cell carcinoma;Cutaneous squamous cell carcinoma (GWAS Catalog (2019-05-03))
UKB P&T Chahal HS et al. 2018 9 3.6e-97 0.0144 0.0819 0.571
0.563-0.579
1.93
OR 95% CI: 1.56-2.39
Binary nominal
172.22 Squamous cell carcinoma
Squamous cell carcinoma;Cutaneous squamous cell carcinoma (GWAS Catalog (2019-05-03))
UKB Fixed threshold (5e-09) Chahal HS et al. 2018 5 7.9e-97 0.0137 0.0819 0.569
0.561-0.577
2.13
OR 95% CI: 1.73-2.61
Binary nominal
172.22 Squamous cell carcinoma
Squamous cell carcinoma;Cutaneous squamous cell carcinoma (GWAS Catalog (2019-05-03))
UKB Fixed threshold (5e-05) Chahal HS et al. 2018 10 4.3e-94 0.014 0.082 0.57
0.562-0.578
1.75
OR 95% CI: 1.4-2.18
Binary nominal
172.22 Squamous cell carcinoma
Squamous cell carcinoma;Cutaneous squamous cell carcinoma (GWAS Catalog (2019-05-03))
UKB Fixed threshold (5e-06) Chahal HS et al. 2018 10 4.3e-94 0.014 0.082 0.57
0.562-0.578
1.75
OR 95% CI: 1.4-2.18
Binary nominal
172.22 Squamous cell carcinoma
Squamous cell carcinoma;Cutaneous squamous cell carcinoma (GWAS Catalog (2019-05-03))
UKB Fixed threshold (5e-07) Chahal HS et al. 2018 10 4.3e-94 0.014 0.082 0.57
0.562-0.578
1.75
OR 95% CI: 1.4-2.18
Binary nominal
172.22 Squamous cell carcinoma
Squamous cell carcinoma;Cutaneous squamous cell carcinoma (GWAS Catalog (2019-05-03))
UKB GWAS Hits Chahal HS et al. 2018 10 4.3e-94 0.014 0.082 0.57
0.562-0.578
1.75
OR 95% CI: 1.4-2.18
Binary nominal
172.22 Squamous cell carcinoma
Cutaneous squamous cell carcinoma
UKB Fixed threshold (5e-07) GWAS Catalog (2019-05-03) 14 4.1e-93 0.0148 0.082 0.575
0.567-0.582
2.19
OR 95% CI: 1.79-2.67
Binary nominal
172.22 Squamous cell carcinoma
Cutaneous squamous cell carcinoma
UKB P&T GWAS Catalog (2019-05-03) 14 4.1e-93 0.0148 0.082 0.575
0.567-0.582
2.19
OR 95% CI: 1.79-2.67
Binary nominal
172.22 Squamous cell carcinoma
Cutaneous squamous cell carcinoma
UKB GWAS Hits GWAS Catalog (2019-05-03) 13 4.2e-89 0.0143 0.082 0.573
0.564-0.58
2.13
OR 95% CI: 1.74-2.61
Binary nominal
172.22 Squamous cell carcinoma
Cutaneous squamous cell carcinoma
UKB Fixed threshold (5e-09) GWAS Catalog (2019-05-03) 7 2.1e-85 0.0132 0.082 0.57
0.563-0.578
1.86
OR 95% CI: 1.5-2.3
Binary nominal
153 Colorectal cancer
Cancer code, self-reported: large bowel cancer/colorectal cancer (UKB GWAS (PHESANT))
UKB Fixed threshold (5e-05) Huyghe JR et al. 2019 87 4.5e-83 0.0336 0.0812 0.617
0.605-0.63
4
OR 95% CI: 3.11-5.13
Binary nominal
153 Colorectal cancer
Cancer code, self-reported: large bowel cancer/colorectal cancer (UKB GWAS (PHESANT))
UKB P&T Huyghe JR et al. 2019 87 4.5e-83 0.0336 0.0812 0.617
0.605-0.63
4
OR 95% CI: 3.11-5.13
Binary nominal
153 Colorectal cancer
Cancer code, self-reported: large bowel cancer/colorectal cancer (UKB GWAS (PHESANT))
UKB Fixed threshold (5e-06) Huyghe JR et al. 2019 85 1.7e-82 0.0334 0.0812 0.617
0.605-0.63
3.85
OR 95% CI: 2.99-4.96
Binary nominal
153 Colorectal cancer
Cancer code, self-reported: large bowel cancer/colorectal cancer (UKB GWAS (PHESANT))
UKB Fixed threshold (5e-07) Huyghe JR et al. 2019 81 6.6e-81 0.033 0.0812 0.616
0.604-0.629
3.85
OR 95% CI: 2.99-4.96
Binary nominal
153 Colorectal cancer
Cancer code, self-reported: large bowel cancer/colorectal cancer (UKB GWAS (PHESANT))
UKB GWAS Hits Huyghe JR et al. 2019 74 3.6e-76 0.031 0.0813 0.612
0.6-0.625
3.85
OR 95% CI: 2.99-4.96
Binary nominal
153 Colorectal cancer
Cancer code, self-reported: large bowel cancer/colorectal cancer (UKB GWAS (PHESANT))
UKB Fixed threshold (5e-09) Huyghe JR et al. 2019 56 4.8e-69 0.0274 0.0814 0.607
0.594-0.62
3.39
OR 95% CI: 2.6-4.41
Binary nominal
172.21 Basal cell carcinoma
Cancer code, self-reported: basal cell carcinoma (UKB GWAS (PHESANT))
MGI Fixed threshold (5e-05) Chahal HS et al. 2018 28 2.5e-67 0.0409 0.106 0.632
0.616-0.647
3.61
OR 95% CI: 2.53-5.15
Binary nominal
172.21 Basal cell carcinoma
Cancer code, self-reported: basal cell carcinoma (UKB GWAS (PHESANT))
MGI Fixed threshold (5e-06) Chahal HS et al. 2018 28 2.5e-67 0.0409 0.106 0.632
0.616-0.647
3.61
OR 95% CI: 2.53-5.15
Binary nominal
172.21 Basal cell carcinoma
Cancer code, self-reported: basal cell carcinoma (UKB GWAS (PHESANT))
MGI Fixed threshold (5e-07) Chahal HS et al. 2018 28 2.5e-67 0.0409 0.106 0.632
0.616-0.647
3.61
OR 95% CI: 2.53-5.15
Binary nominal
172.21 Basal cell carcinoma
Cancer code, self-reported: basal cell carcinoma (UKB GWAS (PHESANT))
MGI GWAS Hits Chahal HS et al. 2018 28 2.5e-67 0.0409 0.106 0.632
0.616-0.647
3.61
OR 95% CI: 2.53-5.15
Binary nominal
172.21 Basal cell carcinoma
Cancer code, self-reported: basal cell carcinoma (UKB GWAS (PHESANT))
MGI P&T Chahal HS et al. 2018 27 3.1e-67 0.0415 0.106 0.632
0.616-0.647
3.79
OR 95% CI: 2.68-5.35
Binary nominal
185 Cancer of prostate
Prostate cancer
MGI PRS-CS Schumacher FR et al. 2019 1119311 6.9e-67 0.0898 0.145 0.668
0.651-0.687
3.61
OR 95% CI: 2.28-5.72
Binary nominal
172.21 Basal cell carcinoma
Cancer code, self-reported: basal cell carcinoma (UKB GWAS (PHESANT))
MGI Fixed threshold (5e-09) Chahal HS et al. 2018 22 7.7e-67 0.0386 0.106 0.631
0.615-0.646
4.04
OR 95% CI: 2.88-5.66
Binary nominal
172.22 Squamous cell carcinoma
Cutaneous squamous cell carcinoma
UKB Fixed threshold (5e-06) GWAS Catalog (2019-05-03) 17 1.7e-66 0.0117 0.0822 0.562
0.555-0.571
1.65
OR 95% CI: 1.32-2.07
Binary nominal
185 Cancer of prostate
Prostate cancer
MGI lassosum Schumacher FR et al. 2019 26418 3.3e-66 0.092 0.145 0.665
0.647-0.684
4.92
OR 95% CI: 3.21-7.55
Binary nominal
174.1 Breast cancer [female]
Overall
MGI PRS-CS Michailidou K et al. 2018 1119140 1e-65 0.0523 0.133 0.651
0.635-0.666
3.22
OR 95% CI: 2.15-4.81
Binary nominal
185 Cancer of prostate
Prostate cancer
MGI P&T Schumacher FR et al. 2019 1301 1.6e-65 0.0898 0.145 0.67
0.652-0.688
3.3
OR 95% CI: 2.06-5.29
Binary nominal
185 Cancer of prostate
Prostate cancer
MGI Fixed threshold (5e-05) Schumacher FR et al. 2019 1223 9.1e-65 0.0891 0.145 0.668
0.651-0.685
3.62
OR 95% CI: 2.27-5.76
Binary nominal
174.1 Breast cancer [female]
ER negative
UKB Fixed threshold (5e-06) Michailidou K et al. 2018 133 2.5e-64 0.0084 0.0824 0.561
0.553-0.568
1.81
OR 95% CI: 1.48-2.22
Binary nominal
185 Cancer of prostate
Prostate cancer
MGI Fixed threshold (5e-06) Schumacher FR et al. 2019 691 3.1e-63 0.085 0.145 0.666
0.649-0.683
4.51
OR 95% CI: 2.94-6.94
Binary nominal
172.21 Basal cell carcinoma
Cancer code, self-reported: basal cell carcinoma (UKB GWAS (PHESANT))
MGI GWAS Hits GWAS Catalog (2019-05-03) 30 7.7e-63 0.0421 0.106 0.63
0.615-0.646
3.95
OR 95% CI: 2.79-5.58
Binary nominal
174.1 Breast cancer [female]
ER negative
UKB GWAS Hits Michailidou K et al. 2018 49 8.9e-63 0.0091 0.0824 0.559
0.551-0.566
2.03
OR 95% CI: 1.67-2.46
Binary nominal
174.1 Breast cancer [female]
ER negative
UKB P&T Michailidou K et al. 2018 49 8.9e-63 0.0091 0.0824 0.559
0.551-0.566
2.03
OR 95% CI: 1.67-2.46
Binary nominal
172.21 Basal cell carcinoma
Cancer code, self-reported: basal cell carcinoma (UKB GWAS (PHESANT))
MGI Fixed threshold (5e-09) GWAS Catalog (2019-05-03) 24 1.9e-62 0.044 0.106 0.629
0.613-0.645
4
OR 95% CI: 2.82-5.68
Binary nominal
172.21 Basal cell carcinoma
Cancer code, self-reported: basal cell carcinoma (UKB GWAS (PHESANT))
MGI Fixed threshold (5e-07) GWAS Catalog (2019-05-03) 31 3.7e-62 0.0426 0.106 0.629
0.614-0.646
3.84
OR 95% CI: 2.71-5.43
Binary nominal
172 Skin cancer
Cancer code, self-reported: skin cancer (UKB GWAS (PHESANT))
MGI P&T UKB GWAS (PheCode) 292 3.8e-62 0.0274 0.146 0.591
0.581-0.602
2.51
OR 95% CI: 1.89-3.34
Binary nominal
172.21 Basal cell carcinoma
Cancer code, self-reported: basal cell carcinoma (UKB GWAS (PHESANT))
MGI P&T GWAS Catalog (2019-05-03) 23 5.4e-62 0.044 0.106 0.628
0.612-0.644
4.03
OR 95% CI: 2.86-5.69
Binary nominal
172.21 Basal cell carcinoma
Cancer code, self-reported: basal cell carcinoma (UKB GWAS (PHESANT))
MGI Fixed threshold (5e-05) GWAS Catalog (2019-05-03) 32 1.3e-61 0.0433 0.106 0.628
0.613-0.644
3.65
OR 95% CI: 2.57-5.18
Binary nominal
172.21 Basal cell carcinoma
Cancer code, self-reported: basal cell carcinoma (UKB GWAS (PHESANT))
MGI Fixed threshold (5e-06) GWAS Catalog (2019-05-03) 32 1.3e-61 0.0433 0.106 0.628
0.613-0.644
3.65
OR 95% CI: 2.57-5.18
Binary nominal
172 Skin cancer
Cancer code, self-reported: skin cancer (UKB GWAS (PHESANT))
MGI Fixed threshold (5e-05) UKB GWAS (PheCode) 365 4.7e-61 0.0267 0.146 0.591
0.581-0.603
1.97
OR 95% CI: 1.46-2.67
Binary nominal
174.1 Breast cancer [female]
ER negative
UKB Fixed threshold (5e-07) Michailidou K et al. 2018 73 7.7e-61 0.0081 0.0824 0.56
0.552-0.567
1.76
OR 95% CI: 1.44-2.16
Binary nominal
172 Skin cancer
Cancer code, self-reported: skin cancer (UKB GWAS (PHESANT))
MGI lassosum UKB GWAS (PheCode) 3166 3.1e-60 0.0256 0.146 0.586
0.575-0.597
2.26
OR 95% CI: 1.69-3.03
Binary nominal
174.1 Breast cancer [female]
ER positive
MGI PRS-CS Michailidou K et al. 2018 1119140 4.7e-59 0.0445 0.134 0.643
0.627-0.658
3.71
OR 95% CI: 2.52-5.47
Binary nominal
174.1 Breast cancer [female]
Overall
MGI lassosum Michailidou K et al. 2018 118388 1.2e-58 0.0505 0.134 0.641
0.625-0.656
2.48
OR 95% CI: 1.63-3.77
Binary nominal
172 Skin cancer
Cancer code, self-reported: skin cancer (UKB GWAS (PHESANT))
MGI Fixed threshold (5e-07) UKB GWAS (PheCode) 105 2.3e-58 0.0251 0.146 0.585
0.575-0.596
2.17
OR 95% CI: 1.62-2.92
Binary nominal
172 Skin cancer
Cancer code, self-reported: skin cancer (UKB GWAS (PHESANT))
MGI Fixed threshold (5e-06) UKB GWAS (PheCode) 159 4.1e-58 0.0263 0.146 0.586
0.576-0.597
2.06
OR 95% CI: 1.53-2.77
Binary nominal
174.1 Breast cancer [female]
ER negative
UKB Fixed threshold (5e-05) Michailidou K et al. 2018 392 1.2e-57 0.0085 0.0825 0.559
0.551-0.566
1.75
OR 95% CI: 1.42-2.15
Binary nominal
172 Skin cancer
Cancer code, self-reported: skin cancer (UKB GWAS (PHESANT))
MGI GWAS Hits UKB GWAS (PheCode) 80 1.6e-57 0.0235 0.146 0.584
0.574-0.594
2.3
OR 95% CI: 1.72-3.09
Binary nominal
172.22 Squamous cell carcinoma
Cutaneous squamous cell carcinoma
UKB Fixed threshold (5e-05) GWAS Catalog (2019-05-03) 18 1.6e-57 0.011 0.0822 0.558
0.551-0.566
1.6
OR 95% CI: 1.27-2.01
Binary nominal
172.2 Other non-epithelial cancer of skin
MGI P&T UKB GWAS (PheCode) 177 4.3e-57 0.0273 0.136 0.591
0.579-0.603
2.89
OR 95% CI: 2.14-3.92
Binary nominal
174.1 Breast cancer [female]
ER negative
UKB Fixed threshold (5e-09) Michailidou K et al. 2018 31 1.3e-56 0.0078 0.0825 0.556
0.548-0.564
1.95
OR 95% CI: 1.6-2.37
Binary nominal
185 Cancer of prostate
Prostate cancer
MGI Fixed threshold (5e-07) Schumacher FR et al. 2019 492 2e-56 0.0878 0.146 0.653
0.636-0.673
4.62
OR 95% CI: 2.99-7.13
Binary nominal
172 Skin cancer
Malignant neoplasm of skin
MGI P&T UKB GWAS (FINNGEN) 389 7.4e-56 0.0247 0.146 0.586
0.576-0.597
2.23
OR 95% CI: 1.64-3.03
Binary nominal
172 Skin cancer
Malignant neoplasm of skin
MGI Fixed threshold (5e-05) UKB GWAS (FINNGEN) 433 9.4e-56 0.0244 0.146 0.586
0.576-0.597
2.48
OR 95% CI: 1.84-3.34
Binary nominal
172.2 Other non-epithelial cancer of skin
MGI Fixed threshold (5e-06) UKB GWAS (PheCode) 160 1.2e-55 0.026 0.136 0.59
0.579-0.602
2.87
OR 95% CI: 2.12-3.89
Binary nominal
185 Cancer of prostate
Prostate cancer
MGI GWAS Hits Schumacher FR et al. 2019 377 1.8e-55 0.0888 0.146 0.651
0.634-0.669
4.44
OR 95% CI: 2.87-6.87
Binary nominal
172.1 Melanomas of skin, dx or hx
Melanoma;Cutaneous malignant melanoma
UKB Fixed threshold (5e-05) GWAS Catalog (2019-05-03) 29 2.8e-55 0.023 0.0812 0.622
0.607-0.637
3.12
OR 95% CI: 2.18-4.46
Binary nominal
172.1 Melanomas of skin, dx or hx
Melanoma;Cutaneous malignant melanoma
UKB Fixed threshold (5e-06) GWAS Catalog (2019-05-03) 29 2.8e-55 0.023 0.0812 0.622
0.607-0.637
3.12
OR 95% CI: 2.18-4.46
Binary nominal
172.2 Other non-epithelial cancer of skin
MGI Fixed threshold (5e-07) UKB GWAS (PheCode) 109 6.9e-55 0.0236 0.136 0.589
0.577-0.601
2.75
OR 95% CI: 2.02-3.75
Binary nominal
185 Cancer of prostate
Prostate cancer
MGI Fixed threshold (5e-09) Schumacher FR et al. 2019 293 1.4e-54 0.0817 0.146 0.648
0.63-0.665
3.99
OR 95% CI: 2.57-6.21
Binary nominal
172.2 Other non-epithelial cancer of skin
MGI lassosum UKB GWAS (PheCode) 7231 2.4e-54 0.0244 0.136 0.59
0.578-0.601
3.5
OR 95% CI: 2.63-4.65
Binary nominal
174.1 Breast cancer [female]
ER positive
MGI lassosum Michailidou K et al. 2018 61635 5.1e-54 0.0433 0.135 0.634
0.618-0.65
4.03
OR 95% CI: 2.78-5.85
Binary nominal
172 Skin cancer
Malignant neoplasm of skin
MGI lassosum UKB GWAS (FINNGEN) 16316 1.4e-53 0.0218 0.146 0.584
0.573-0.594
1.65
OR 95% CI: 1.2-2.27
Binary nominal
185 Cancer of prostate
Prostate cancer;Prostate cancer (early onset)
MGI GWAS Hits GWAS Catalog (2019-05-03) 117 1.9e-53 0.0628 0.147 0.646
0.627-0.665
3.57
OR 95% CI: 2.29-5.57
Binary nominal
172.2 Other non-epithelial cancer of skin
MGI GWAS Hits UKB GWAS (PheCode) 77 2.2e-53 0.0203 0.136 0.586
0.574-0.599
2.65
OR 95% CI: 1.94-3.62
Binary nominal
174.1 Breast cancer [female]
Overall
MGI P&T Michailidou K et al. 2018 3038 2.2e-53 0.041 0.135 0.635
0.618-0.651
2.84
OR 95% CI: 1.88-4.28
Binary nominal
172 Skin cancer
Cancer code, self-reported: skin cancer (UKB GWAS (PHESANT))
MGI Fixed threshold (5e-09) UKB GWAS (PheCode) 60 2.4e-53 0.0215 0.146 0.58
0.57-0.59
2.68
OR 95% CI: 2.02-3.55
Binary nominal
185 Cancer of prostate
Prostate cancer;Prostate cancer (early onset)
MGI Fixed threshold (5e-05) GWAS Catalog (2019-05-03) 124 3.6e-53 0.0667 0.147 0.646
0.627-0.664
3.41
OR 95% CI: 2.17-5.35
Binary nominal
185 Cancer of prostate
Prostate cancer;Prostate cancer (early onset)
MGI Fixed threshold (5e-06) GWAS Catalog (2019-05-03) 124 3.6e-53 0.0667 0.147 0.646
0.627-0.664
3.41
OR 95% CI: 2.17-5.35
Binary nominal
185 Cancer of prostate
Prostate cancer;Prostate cancer (early onset)
MGI Fixed threshold (5e-07) GWAS Catalog (2019-05-03) 123 7e-53 0.0667 0.147 0.646
0.627-0.663
3.64
OR 95% CI: 2.33-5.68
Binary nominal
172.2 Other non-epithelial cancer of skin
MGI Fixed threshold (5e-09) UKB GWAS (PheCode) 61 7.2e-53 0.0204 0.137 0.584
0.572-0.596
3.09
OR 95% CI: 2.28-4.19
Binary nominal
185 Cancer of prostate
Prostate cancer;Prostate cancer (early onset)
MGI P&T GWAS Catalog (2019-05-03) 122 7.2e-53 0.0667 0.147 0.646
0.627-0.664
3.53
OR 95% CI: 2.26-5.51
Binary nominal
174.1 Breast cancer [female]
Overall
MGI Fixed threshold (5e-05) Michailidou K et al. 2018 1307 1.9e-52 0.0392 0.135 0.634
0.618-0.65
2.75
OR 95% CI: 1.81-4.17
Binary nominal
172.1 Melanomas of skin, dx or hx
Melanoma;Cutaneous malignant melanoma
UKB Fixed threshold (5e-07) GWAS Catalog (2019-05-03) 27 3.3e-52 0.0233 0.0812 0.619
0.603-0.634
3.12
OR 95% CI: 2.18-4.47
Binary nominal
172.1 Melanomas of skin, dx or hx
Melanoma;Cutaneous malignant melanoma
UKB P&T GWAS Catalog (2019-05-03) 27 3.3e-52 0.0233 0.0812 0.619
0.603-0.634
3.12
OR 95% CI: 2.18-4.47
Binary nominal
172.2 Other non-epithelial cancer of skin
MGI Fixed threshold (5e-05) UKB GWAS (PheCode) 367 1.8e-51 0.0268 0.137 0.587
0.576-0.599
3
OR 95% CI: 2.23-4.04
Binary nominal
172 Skin cancer
Malignant neoplasm of skin
MGI Fixed threshold (5e-06) UKB GWAS (FINNGEN) 208 3.7e-51 0.0233 0.146 0.583
0.572-0.593
2.04
OR 95% CI: 1.5-2.79
Binary nominal
185 Cancer of prostate
Prostate cancer;Prostate cancer (early onset)
MGI Fixed threshold (5e-09) GWAS Catalog (2019-05-03) 86 4.3e-51 0.0563 0.147 0.643
0.625-0.661
2.97
OR 95% CI: 1.85-4.75
Binary nominal
172 Skin cancer
Malignant neoplasm of skin
MGI Fixed threshold (5e-07) UKB GWAS (FINNGEN) 135 5.3e-51 0.0221 0.146 0.582
0.571-0.593
2.02
OR 95% CI: 1.48-2.76
Binary nominal
172 Skin cancer
Malignant neoplasm of skin
MGI GWAS Hits UKB GWAS (FINNGEN) 95 2.9e-50 0.0217 0.146 0.581
0.57-0.592
2.2
OR 95% CI: 1.63-2.98
Binary nominal
172.1 Melanomas of skin, dx or hx
Melanoma;Cutaneous malignant melanoma
UKB GWAS Hits GWAS Catalog (2019-05-03) 18 5.1e-50 0.02 0.0813 0.615
0.599-0.63
2.57
OR 95% CI: 1.75-3.77
Binary nominal
172.2 Other non-epithelial cancer of skin
Other malignant neoplasms of skin
MGI Fixed threshold (5e-06) UKB GWAS (FINNGEN) 207 6.4e-50 0.0228 0.137 0.588
0.576-0.601
2.63
OR 95% CI: 1.93-3.59
Binary nominal
172.2 Other non-epithelial cancer of skin
Other malignant neoplasms of skin
MGI Fixed threshold (5e-07) UKB GWAS (FINNGEN) 139 7.1e-50 0.0216 0.137 0.586
0.574-0.599
2.78
OR 95% CI: 2.05-3.77
Binary nominal
172.1 Melanomas of skin, dx or hx
UKB Fixed threshold (5e-05) Ransohoff KJ et al. 2017 20 7.9e-50 0.0193 0.0813 0.62
0.604-0.635
2.81
OR 95% CI: 1.93-4.07
Binary nominal
172.1 Melanomas of skin, dx or hx
UKB Fixed threshold (5e-06) Ransohoff KJ et al. 2017 20 7.9e-50 0.0193 0.0813 0.62
0.604-0.635
2.81
OR 95% CI: 1.93-4.07
Binary nominal
172.1 Melanomas of skin, dx or hx
UKB Fixed threshold (5e-07) Ransohoff KJ et al. 2017 20 7.9e-50 0.0193 0.0813 0.62
0.604-0.635
2.81
OR 95% CI: 1.93-4.07
Binary nominal
172.1 Melanomas of skin, dx or hx
UKB GWAS Hits Ransohoff KJ et al. 2017 20 7.9e-50 0.0193 0.0813 0.62
0.604-0.635
2.81
OR 95% CI: 1.93-4.07
Binary nominal
172.1 Melanomas of skin, dx or hx
UKB P&T Ransohoff KJ et al. 2017 20 7.9e-50 0.0193 0.0813 0.62
0.604-0.635
2.81
OR 95% CI: 1.93-4.07
Binary nominal
172 Skin cancer
Malignant neoplasm of skin
MGI Fixed threshold (5e-09) UKB GWAS (FINNGEN) 78 1.2e-49 0.0204 0.146 0.58
0.569-0.591
2.45
OR 95% CI: 1.82-3.29
Binary nominal
172 Skin cancer
Malignant neoplasm of skin
MGI PRS-CS UKB GWAS (FINNGEN) 1111490 2e-49 0.0232 0.146 0.581
0.57-0.591
2.25
OR 95% CI: 1.67-3.03
Binary nominal
174.1 Breast cancer [female]
Overall
MGI Fixed threshold (5e-06) Michailidou K et al. 2018 712 3.8e-49 0.0388 0.135 0.629
0.612-0.645
3.06
OR 95% CI: 2.04-4.59
Binary nominal
174.1 Breast cancer [female]
Overall
MGI Fixed threshold (5e-07) Michailidou K et al. 2018 464 8e-49 0.0385 0.135 0.627
0.611-0.644
3.38
OR 95% CI: 2.28-5.02
Binary nominal
172 Skin cancer
Cancer code, self-reported: skin cancer (UKB GWAS (PHESANT))
MGI PRS-CS UKB GWAS (PheCode) 1119238 1.8e-48 0.0211 0.146 0.58
0.57-0.591
2.42
OR 95% CI: 1.81-3.24
Binary nominal
172.2 Other non-epithelial cancer of skin
Other malignant neoplasms of skin
MGI Fixed threshold (5e-09) UKB GWAS (FINNGEN) 85 2.2e-48 0.0206 0.137 0.585
0.573-0.598
2.82
OR 95% CI: 2.07-3.83
Binary nominal
172.2 Other non-epithelial cancer of skin
Other malignant neoplasms of skin
MGI GWAS Hits UKB GWAS (FINNGEN) 108 1e-47 0.0199 0.137 0.584
0.572-0.598
2.73
OR 95% CI: 2.01-3.72
Binary nominal
174.1 Breast cancer [female]
Overall
MGI GWAS Hits Michailidou K et al. 2018 334 1.6e-47 0.0372 0.136 0.625
0.609-0.641
3.32
OR 95% CI: 2.24-4.93
Binary nominal
185 Cancer of prostate
Malignant neoplasm of prostate
MGI Fixed threshold (5e-07) UKB GWAS (FINNGEN) 67 1.8e-47 0.0614 0.148 0.638
0.62-0.656
3.69
OR 95% CI: 2.36-5.75
Binary nominal
174.1 Breast cancer [female]
Overall
MGI lassosum Michailidou K et al. 2018 18356 2.7e-47 0.0336 0.136 0.624
0.607-0.641
2.49
OR 95% CI: 1.61-3.84
Binary nominal
172.1 Melanomas of skin, dx or hx
Ransohoff KJ et al. 2017
MGI GWAS Hits UKB GWAS (PheCode) 12 8e-47 0.0207 0.0951 0.606
0.591-0.622
2.62
OR 95% CI: 1.77-3.88
Binary nominal
174.1 Breast cancer [female]
Overall
MGI Fixed threshold (5e-09) Michailidou K et al. 2018 264 1.7e-46 0.0358 0.136 0.624
0.608-0.64
2.56
OR 95% CI: 1.68-3.9
Binary nominal
172.2 Other non-epithelial cancer of skin
Other malignant neoplasms of skin
MGI lassosum UKB GWAS (FINNGEN) 16626 3.2e-46 0.0257 0.137 0.584
0.571-0.596
2.22
OR 95% CI: 1.61-3.06
Binary nominal
172.2 Other non-epithelial cancer of skin
ICD-10 C44 Other malignant neoplasms of skin
MGI Fixed threshold (5e-07) UKB GWAS (ICD10) 89 3.5e-46 0.0201 0.137 0.581
0.569-0.594
2.37
OR 95% CI: 1.72-3.28
Binary nominal
172.2 Other non-epithelial cancer of skin
ICD-10 C44 Other malignant neoplasms of skin
MGI Fixed threshold (5e-06) UKB GWAS (ICD10) 131 5.9e-46 0.0207 0.137 0.582
0.569-0.594
2.38
OR 95% CI: 1.73-3.26
Binary nominal
172.2 Other non-epithelial cancer of skin
Other malignant neoplasms of skin
MGI PRS-CS UKB GWAS (FINNGEN) 1111490 1.1e-45 0.0282 0.137 0.586
0.573-0.598
1.99
OR 95% CI: 1.43-2.78
Binary nominal
174.1 Breast cancer [female]
Overall
MGI PRS-CS Michailidou K et al. 2018 1115484 1.3e-45 0.0295 0.135 0.622
0.605-0.638
3.43
OR 95% CI: 2.32-5.05
Binary nominal
172.2 Other non-epithelial cancer of skin
ICD-10 C44 Other malignant neoplasms of skin
MGI GWAS Hits UKB GWAS (ICD10) 63 1.5e-45 0.0198 0.137 0.579
0.566-0.592
2.21
OR 95% CI: 1.6-3.06
Binary nominal
172.2 Other non-epithelial cancer of skin
Other malignant neoplasms of skin
MGI Fixed threshold (5e-05) UKB GWAS (FINNGEN) 446 1.6e-45 0.0247 0.137 0.584
0.572-0.597
2.7
OR 95% CI: 1.99-3.66
Binary nominal
172.2 Other non-epithelial cancer of skin
Other malignant neoplasms of skin
MGI P&T UKB GWAS (FINNGEN) 446 1.6e-45 0.0247 0.137 0.584
0.572-0.597
2.7
OR 95% CI: 1.99-3.66
Binary nominal
185 Cancer of prostate
Malignant neoplasm of prostate
MGI P&T UKB GWAS (FINNGEN) 100 2.3e-45 0.0656 0.148 0.634
0.617-0.653
2.96
OR 95% CI: 1.85-4.74
Binary nominal
172.2 Other non-epithelial cancer of skin
MGI PRS-CS UKB GWAS (PheCode) 1119238 6.7e-45 0.0222 0.137 0.584
0.572-0.595
2.35
OR 95% CI: 1.71-3.22
Binary nominal
174.1 Breast cancer [female]
ER positive
MGI P&T Michailidou K et al. 2018 1142 8.1e-45 0.0356 0.136 0.621
0.605-0.638
2.7
OR 95% CI: 1.77-4.1
Binary nominal
172.2 Other non-epithelial cancer of skin
ICD-10 C44 Other malignant neoplasms of skin
MGI lassosum UKB GWAS (ICD10) 2111 1.6e-44 0.021 0.137 0.581
0.569-0.592
2.55
OR 95% CI: 1.87-3.46
Binary nominal
185 Cancer of prostate
Malignant neoplasm of prostate
MGI Fixed threshold (5e-06) UKB GWAS (FINNGEN) 118 1.6e-44 0.064 0.148 0.633
0.615-0.651
3.22
OR 95% CI: 2.03-5.09
Binary nominal
174.1 Breast cancer [female]
ER negative
UKB Fixed threshold (5e-07) Michailidou K et al. 2018 14 2.2e-44 0.0058 0.0825 0.547
0.54-0.555
1.73
OR 95% CI: 1.41-2.13
Binary nominal
174.1 Breast cancer [female]
ER negative
UKB P&T Michailidou K et al. 2018 14 2.2e-44 0.0058 0.0825 0.547
0.54-0.555
1.73
OR 95% CI: 1.41-2.13
Binary nominal
172.1 Melanomas of skin, dx or hx
Ransohoff KJ et al. 2017
MGI P&T UKB GWAS (PheCode) 15 9.1e-44 0.0211 0.0952 0.604
0.587-0.62
2.97
OR 95% CI: 2.04-4.34
Binary nominal
174.1 Breast cancer [female]
ER negative
UKB lassosum Michailidou K et al. 2018 2708 9.9e-44 0.0055 0.0825 0.547
0.54-0.555
1.72
OR 95% CI: 1.4-2.11
Binary nominal
172.2 Other non-epithelial cancer of skin
ICD-10 C44 Other malignant neoplasms of skin
MGI P&T UKB GWAS (ICD10) 467 1.3e-43 0.0239 0.137 0.583
0.57-0.595
2.17
OR 95% CI: 1.57-3.01
Binary nominal
185 Cancer of prostate
Prostate cancer (Schumacher FR et al. 2019)
MGI Fixed threshold (5e-07) UKB GWAS (PheCode) 64 2.6e-43 0.0576 0.148 0.631
0.612-0.649
3.8
OR 95% CI: 2.44-5.92
Binary nominal
172.1 Melanomas of skin, dx or hx
Ransohoff KJ et al. 2017
MGI Fixed threshold (5e-07) UKB GWAS (PheCode) 19 3.5e-43 0.0188 0.0952 0.604
0.588-0.62
2.68
OR 95% CI: 1.81-3.98
Binary nominal
185 Cancer of prostate
Malignant neoplasm of prostate
MGI GWAS Hits UKB GWAS (FINNGEN) 49 3.5e-43 0.0562 0.148 0.63
0.613-0.648
2.86
OR 95% CI: 1.79-4.57
Binary nominal
172.2 Other non-epithelial cancer of skin
ICD-10 C44 Other malignant neoplasms of skin
MGI Fixed threshold (5e-05) UKB GWAS (ICD10) 321 3.7e-43 0.0232 0.137 0.581
0.569-0.593
2.05
OR 95% CI: 1.46-2.86
Binary nominal
172.1 Melanomas of skin, dx or hx
ICD-10 C43 Malignant melanoma of skin
MGI GWAS Hits UKB GWAS (ICD10) 9 5.2e-43 0.0174 0.0952 0.598
0.582-0.613
2.88
OR 95% CI: 1.96-4.21
Binary nominal
172.1 Melanomas of skin, dx or hx
ICD-10 C43 Malignant melanoma of skin
MGI P&T UKB GWAS (ICD10) 9 5.2e-43 0.0174 0.0952 0.598
0.582-0.613
2.88
OR 95% CI: 1.96-4.21
Binary nominal
185 Cancer of prostate
Prostate cancer (Schumacher FR et al. 2019)
MGI GWAS Hits UKB GWAS (PheCode) 42 5.8e-43 0.0548 0.148 0.63
0.612-0.648
3.14
OR 95% CI: 1.99-4.96
Binary nominal
174.1 Breast cancer [female]
ER positive
MGI Fixed threshold (5e-05) Michailidou K et al. 2018 950 6.5e-43 0.0348 0.136 0.618
0.602-0.635
2.91
OR 95% CI: 1.93-4.4
Binary nominal
172.2 Other non-epithelial cancer of skin
ICD-10 C44 Other malignant neoplasms of skin
MGI Fixed threshold (5e-09) UKB GWAS (ICD10) 51 1.5e-42 0.0177 0.137 0.574
0.562-0.587
2.07
OR 95% CI: 1.48-2.89
Binary nominal
172.1 Melanomas of skin, dx or hx
UKB Fixed threshold (5e-09) Ransohoff KJ et al. 2017 15 7.1e-42 0.0165 0.0815 0.61
0.593-0.624
2.25
OR 95% CI: 1.5-3.38
Binary nominal
185 Cancer of prostate
Prostate cancer (Schumacher FR et al. 2019)
MGI Fixed threshold (5e-06) UKB GWAS (PheCode) 110 3e-41 0.0592 0.149 0.628
0.61-0.647
3.55
OR 95% CI: 2.26-5.58
Binary nominal
185 Cancer of prostate
Prostate cancer (Schumacher FR et al. 2019)
MGI Fixed threshold (5e-09) UKB GWAS (PheCode) 32 1e-40 0.052 0.149 0.627
0.609-0.644
2.51
OR 95% CI: 1.54-4.07
Binary nominal
174.1 Breast cancer [female]
Overall
MGI Fixed threshold (5e-06) Michailidou K et al. 2018 246 1.2e-40 0.0251 0.136 0.613
0.597-0.631
2.8
OR 95% CI: 1.85-4.25
Binary nominal
174.1 Breast cancer [female]
Overall
MGI Fixed threshold (5e-07) Michailidou K et al. 2018 154 1.4e-40 0.0217 0.136 0.614
0.598-0.63
2.28
OR 95% CI: 1.46-3.54
Binary nominal
185 Cancer of prostate
ICD-10 C61 Malignant neoplasm of prostate
MGI GWAS Hits UKB GWAS (ICD10) 31 2.6e-40 0.0545 0.149 0.622
0.603-0.641
2.93
OR 95% CI: 1.83-4.7
Binary nominal
174.1 Breast cancer [female]
ER positive
MGI GWAS Hits Michailidou K et al. 2018 257 2.8e-40 0.0285 0.136 0.614
0.599-0.63
2.35
OR 95% CI: 1.51-3.66
Binary nominal
185 Cancer of prostate
Prostate cancer (Schumacher FR et al. 2019)
MGI P&T UKB GWAS (PheCode) 80 5.9e-40 0.0596 0.149 0.627
0.608-0.645
3.18
OR 95% CI: 2.01-5.02
Binary nominal
172.1 Melanomas of skin, dx or hx
Melanoma;Cutaneous malignant melanoma
UKB Fixed threshold (5e-09) GWAS Catalog (2019-05-03) 12 1.3e-39 0.0167 0.0816 0.6
0.584-0.615
2.65
OR 95% CI: 1.81-3.88
Binary nominal
174.1 Breast cancer [female]
ER positive
MGI Fixed threshold (5e-06) Michailidou K et al. 2018 495 2e-39 0.032 0.136 0.613
0.596-0.629
2.29
OR 95% CI: 1.47-3.56
Binary nominal
185 Cancer of prostate
Malignant neoplasm of prostate
MGI Fixed threshold (5e-09) UKB GWAS (FINNGEN) 43 2.1e-39 0.0562 0.149 0.624
0.605-0.642
3.06
OR 95% CI: 1.93-4.85
Binary nominal
172.1 Melanomas of skin, dx or hx
Melanoma;Cutaneous malignant melanoma
MGI Fixed threshold (5e-05) GWAS Catalog (2019-05-03) 29 2.4e-39 0.0286 0.0954 0.608
0.592-0.623
2.93
OR 95% CI: 2-4.3
Binary nominal
172.1 Melanomas of skin, dx or hx
Melanoma;Cutaneous malignant melanoma
MGI Fixed threshold (5e-06) GWAS Catalog (2019-05-03) 29 2.4e-39 0.0286 0.0954 0.608
0.592-0.623
2.93
OR 95% CI: 2-4.3
Binary nominal
172.1 Melanomas of skin, dx or hx
Melanoma;Cutaneous malignant melanoma
MGI P&T GWAS Catalog (2019-05-03) 29 2.4e-39 0.0286 0.0954 0.608
0.592-0.623
2.93
OR 95% CI: 2-4.3
Binary nominal
174.1 Breast cancer [female]
ER positive
MGI Fixed threshold (5e-09) Michailidou K et al. 2018 210 2.6e-39 0.0267 0.136 0.612
0.596-0.628
2.82
OR 95% CI: 1.86-4.27
Binary nominal
174.1 Breast cancer [female]
ER positive
MGI Fixed threshold (5e-07) Michailidou K et al. 2018 343 3.9e-39 0.0302 0.136 0.612
0.596-0.628
2.47
OR 95% CI: 1.6-3.81
Binary nominal
174.1 Breast cancer [female]
ER positive
MGI PRS-CS Michailidou K et al. 2018 1115436 4.2e-39 0.0285 0.136 0.613
0.595-0.63
3.75
OR 95% CI: 2.55-5.51
Binary nominal
172.1 Melanomas of skin, dx or hx
ICD-10 C43 Malignant melanoma of skin
MGI Fixed threshold (5e-07) UKB GWAS (ICD10) 14 5.2e-39 0.0144 0.0954 0.594
0.579-0.609
2.58
OR 95% CI: 1.73-3.84
Binary nominal
172.1 Melanomas of skin, dx or hx
Malignant melanoma of skin
MGI Fixed threshold (5e-09) UKB GWAS (FINNGEN) 11 1.1e-38 0.015 0.0954 0.591
0.575-0.607
2.91
OR 95% CI: 1.99-4.26
Binary nominal
174.1 Breast cancer [female]
ER negative
UKB PRS-CS Michailidou K et al. 2018 1116435 2.1e-38 0.0031 0.0826 0.549
0.542-0.556
1.82
OR 95% CI: 1.48-2.22
Binary nominal
185 Cancer of prostate
ICD-10 C61 Malignant neoplasm of prostate
MGI Fixed threshold (5e-06) UKB GWAS (ICD10) 80 2.6e-38 0.0566 0.149 0.621
0.603-0.64
2.65
OR 95% CI: 1.63-4.3
Binary nominal
174.1 Breast cancer [female]
ER positive
MGI lassosum Michailidou K et al. 2018 98026 2.7e-38 0.0305 0.136 0.61
0.594-0.626
2.29
OR 95% CI: 1.47-3.59
Binary nominal
172.1 Melanomas of skin, dx or hx
Melanoma;Cutaneous malignant melanoma
MGI Fixed threshold (5e-07) GWAS Catalog (2019-05-03) 27 4.8e-38 0.0283 0.0954 0.606
0.589-0.621
2.59
OR 95% CI: 1.74-3.86
Binary nominal
172.1 Melanomas of skin, dx or hx
Malignant melanoma of skin
MGI P&T UKB GWAS (FINNGEN) 21 4.9e-38 0.0167 0.0954 0.593
0.576-0.609
2.97
OR 95% CI: 2.02-4.36
Binary nominal
172.1 Melanomas of skin, dx or hx
Malignant melanoma of skin
MGI Fixed threshold (5e-07) UKB GWAS (FINNGEN) 22 5.2e-38 0.0164 0.0954 0.592
0.577-0.608
2.83
OR 95% CI: 1.92-4.18
Binary nominal
185 Cancer of prostate
Malignant neoplasm of prostate
MGI Fixed threshold (5e-05) UKB GWAS (FINNGEN) 290 7.7e-38 0.0605 0.149 0.626
0.607-0.644
2.41
OR 95% CI: 1.45-4.01
Binary nominal
174.1 Breast cancer [female]
Overall
MGI P&T Michailidou K et al. 2018 363 8e-38 0.0258 0.136 0.609
0.592-0.626
3.44
OR 95% CI: 2.31-5.13
Binary nominal
172.1 Melanomas of skin, dx or hx
Ransohoff KJ et al. 2017
MGI Fixed threshold (5e-06) UKB GWAS (PheCode) 34 2.1e-37 0.0181 0.0955 0.596
0.58-0.613
2.21
OR 95% CI: 1.45-3.37
Binary nominal
174.1 Breast cancer [female]
Overall
MGI GWAS Hits Michailidou K et al. 2018 110 2.8e-37 0.0214 0.137 0.607
0.591-0.623
2.51
OR 95% CI: 1.63-3.86
Binary nominal
172.1 Melanomas of skin, dx or hx
Ransohoff KJ et al. 2017
MGI Fixed threshold (5e-09) UKB GWAS (PheCode) 9 3.3e-37 0.0146 0.0955 0.588
0.573-0.605
2.82
OR 95% CI: 1.92-4.14
Binary nominal
185 Cancer of prostate
ICD-10 C61 Malignant neoplasm of prostate
MGI Fixed threshold (5e-07) UKB GWAS (ICD10) 47 5e-37 0.0627 0.149 0.619
0.601-0.637
3.1
OR 95% CI: 1.96-4.92
Binary nominal
185 Cancer of prostate
ICD-10 C61 Malignant neoplasm of prostate
MGI P&T UKB GWAS (ICD10) 47 5e-37 0.0627 0.149 0.619
0.601-0.637
3.1
OR 95% CI: 1.96-4.92
Binary nominal
174.1 Breast cancer [female]
Breast cancer;Breast cancer (estrogen-receptor negative);Breast Cancer in BRCA1 mutation carriers;Breast cancer in BRCA2 mutation carriers
MGI Fixed threshold (5e-05) GWAS Catalog (2019-05-03) 62 5.2e-37 0.0208 0.136 0.607
0.589-0.623
3.06
OR 95% CI: 2.04-4.6
Binary nominal
174.1 Breast cancer [female]
Breast cancer;Breast cancer (estrogen-receptor negative);Breast Cancer in BRCA1 mutation carriers;Breast cancer in BRCA2 mutation carriers
MGI Fixed threshold (5e-06) GWAS Catalog (2019-05-03) 62 5.2e-37 0.0208 0.136 0.607
0.589-0.623
3.06
OR 95% CI: 2.04-4.6
Binary nominal
174.1 Breast cancer [female]
Breast cancer;Breast cancer (estrogen-receptor negative);Breast Cancer in BRCA1 mutation carriers;Breast cancer in BRCA2 mutation carriers
MGI Fixed threshold (5e-07) GWAS Catalog (2019-05-03) 62 5.2e-37 0.0208 0.136 0.607
0.589-0.623
3.06
OR 95% CI: 2.04-4.6
Binary nominal
174.1 Breast cancer [female]
Breast cancer;Breast cancer (estrogen-receptor negative);Breast Cancer in BRCA1 mutation carriers;Breast cancer in BRCA2 mutation carriers
MGI Fixed threshold (5e-09) GWAS Catalog (2019-05-03) 62 5.2e-37 0.0208 0.136 0.607
0.589-0.623
3.06
OR 95% CI: 2.04-4.6
Binary nominal
174.1 Breast cancer [female]
Breast cancer;Breast cancer (estrogen-receptor negative);Breast Cancer in BRCA1 mutation carriers;Breast cancer in BRCA2 mutation carriers
MGI GWAS Hits GWAS Catalog (2019-05-03) 62 5.2e-37 0.0208 0.136 0.607
0.589-0.623
3.06
OR 95% CI: 2.04-4.6
Binary nominal
174.1 Breast cancer [female]
Breast cancer;Breast cancer (estrogen-receptor negative);Breast Cancer in BRCA1 mutation carriers;Breast cancer in BRCA2 mutation carriers
MGI P&T GWAS Catalog (2019-05-03) 62 5.2e-37 0.0208 0.136 0.607
0.589-0.623
3.06
OR 95% CI: 2.04-4.6
Binary nominal
174.1 Breast cancer [female]
ER negative
UKB GWAS Hits Michailidou K et al. 2018 10 1.8e-36 0.0049 0.0826 0.542
0.534-0.55
1.49
OR 95% CI: 1.2-1.86
Binary nominal
185 Cancer of prostate
Malignant neoplasm of prostate
MGI PRS-CS UKB GWAS (FINNGEN) 1111493 2e-36 0.0414 0.149 0.622
0.604-0.639
2.66
OR 95% CI: 1.63-4.34
Binary nominal
174.1 Breast cancer [female]
Breast cancer [female], Overall (Michailidou K et al. 2018)
MGI lassosum UKB GWAS (PheCode) 6977 2.4e-36 0.0261 0.137 0.609
0.592-0.624
1.94
OR 95% CI: 1.21-3.11
Binary nominal
172.1 Melanomas of skin, dx or hx
Melanoma;Cutaneous malignant melanoma
MGI Fixed threshold (5e-09) GWAS Catalog (2019-05-03) 12 3.5e-36 0.0252 0.0954 0.598
0.582-0.614
2.92
OR 95% CI: 2-4.26
Binary nominal
172.2 Other non-epithelial cancer of skin
ICD-10 C44 Other malignant neoplasms of skin
MGI PRS-CS UKB GWAS (ICD10) 1111490 6.6e-36 0.0182 0.137 0.575
0.562-0.587
1.79
OR 95% CI: 1.28-2.51
Binary nominal
172.1 Melanomas of skin, dx or hx
MGI Fixed threshold (5e-09) Ransohoff KJ et al. 2017 15 1.2e-35 0.0269 0.0954 0.603
0.587-0.619
3.18
OR 95% CI: 2.2-4.61
Binary nominal
172.1 Melanomas of skin, dx or hx
Melanoma;Cutaneous malignant melanoma
MGI GWAS Hits GWAS Catalog (2019-05-03) 18 1.3e-35 0.0272 0.0955 0.6
0.584-0.616
2.39
OR 95% CI: 1.58-3.61
Binary nominal
172.1 Melanomas of skin, dx or hx
Self-reported malignant melanoma
MGI P&T UKB GWAS (PHESANT) 7 4.2e-35 0.0148 0.0956 0.578
0.562-0.594
2.65
OR 95% CI: 1.79-3.93
Binary nominal
185 Cancer of prostate
Prostate cancer (Schumacher FR et al. 2019)
MGI Fixed threshold (5e-05) UKB GWAS (PheCode) 243 7.5e-35 0.0526 0.15 0.616
0.598-0.634
2.9
OR 95% CI: 1.79-4.7
Binary nominal
174.1 Breast cancer [female]
Overall
MGI Fixed threshold (5e-05) Michailidou K et al. 2018 534 8.9e-35 0.0251 0.137 0.608
0.591-0.625
2.44
OR 95% CI: 1.56-3.81
Binary nominal
172.1 Melanomas of skin, dx or hx
Malignant melanoma of skin
MGI GWAS Hits UKB GWAS (FINNGEN) 16 9.4e-35 0.0135 0.0955 0.585
0.569-0.6
3.26
OR 95% CI: 2.26-4.7
Binary nominal
172.1 Melanomas of skin, dx or hx
MGI Fixed threshold (5e-05) Ransohoff KJ et al. 2017 20 1.2e-34 0.0295 0.0955 0.601
0.585-0.617
2.54
OR 95% CI: 1.7-3.8
Binary nominal
172.1 Melanomas of skin, dx or hx
MGI Fixed threshold (5e-06) Ransohoff KJ et al. 2017 20 1.2e-34 0.0295 0.0955 0.601
0.585-0.617
2.54
OR 95% CI: 1.7-3.8
Binary nominal
172.1 Melanomas of skin, dx or hx
MGI Fixed threshold (5e-07) Ransohoff KJ et al. 2017 20 1.2e-34 0.0295 0.0955 0.601
0.585-0.617
2.54
OR 95% CI: 1.7-3.8
Binary nominal
172.1 Melanomas of skin, dx or hx
MGI GWAS Hits Ransohoff KJ et al. 2017 20 1.2e-34 0.0295 0.0955 0.601
0.585-0.617
2.54
OR 95% CI: 1.7-3.8
Binary nominal
172.1 Melanomas of skin, dx or hx
MGI P&T Ransohoff KJ et al. 2017 20 1.2e-34 0.0295 0.0955 0.601
0.585-0.617
2.54
OR 95% CI: 1.7-3.8
Binary nominal
174.1 Breast cancer [female]
Overall
MGI Fixed threshold (5e-09) Michailidou K et al. 2018 77 1.4e-34 0.0211 0.137 0.603
0.587-0.62
2.33
OR 95% CI: 1.51-3.6
Binary nominal
172.21 Basal cell carcinoma
Self-reported basal cell carcinoma
MGI lassosum UKB GWAS (PHESANT) 183 2.7e-34 0.0202 0.108 0.587
0.57-0.604
2.93
OR 95% CI: 2.03-4.25
Binary nominal
174.1 Breast cancer [female]
Breast cancer [female], Overall (Michailidou K et al. 2018)
MGI Fixed threshold (5e-06) UKB GWAS (PheCode) 109 3.3e-34 0.017 0.137 0.605
0.588-0.622
2.21
OR 95% CI: 1.41-3.45
Binary nominal
172.1 Melanomas of skin, dx or hx
Malignant melanoma of skin
MGI lassosum UKB GWAS (FINNGEN) 505 6.5e-34 0.0176 0.0957 0.578
0.562-0.595
2.34
OR 95% CI: 1.55-3.53
Binary nominal
172.1 Melanomas of skin, dx or hx
Self-reported malignant melanoma
MGI lassosum UKB GWAS (PHESANT) 185 9.8e-34 0.0175 0.0957 0.571
0.555-0.587
2
OR 95% CI: 1.29-3.09
Binary nominal
172.1 Melanomas of skin, dx or hx
Ransohoff KJ et al. 2017
MGI lassosum UKB GWAS (PheCode) 296 1.1e-33 0.0185 0.0957 0.582
0.566-0.599
1.99
OR 95% CI: 1.29-3.07
Binary nominal
172.1 Melanomas of skin, dx or hx
Self-reported malignant melanoma
MGI Fixed threshold (5e-07) UKB GWAS (PHESANT) 14 2.1e-33 0.0142 0.0956 0.58
0.565-0.597
2.48
OR 95% CI: 1.66-3.7
Binary nominal
185 Cancer of prostate
ICD-10 C61 Malignant neoplasm of prostate
MGI Fixed threshold (5e-09) UKB GWAS (ICD10) 21 2.1e-33 0.0466 0.15 0.61
0.591-0.628
2.64
OR 95% CI: 1.63-4.27
Binary nominal
185 Cancer of prostate
Prostate cancer (Schumacher FR et al. 2019)
MGI lassosum UKB GWAS (PheCode) 1334 2.5e-33 0.0503 0.15 0.616
0.598-0.635
2.55
OR 95% CI: 1.55-4.2
Binary nominal
174.1 Breast cancer [female]
Breast cancer [female], Overall (Michailidou K et al. 2018)
MGI P&T UKB GWAS (PheCode) 84 2.8e-33 0.0183 0.137 0.605
0.588-0.621
2.09
OR 95% CI: 1.31-3.32
Binary nominal
174.1 Breast cancer [female]
ER positive
MGI Fixed threshold (5e-06) Michailidou K et al. 2018 185 3.2e-33 0.0228 0.137 0.601
0.584-0.617
2.94
OR 95% CI: 1.95-4.44
Binary nominal
185 Cancer of prostate
Malignant neoplasm of prostate
MGI lassosum UKB GWAS (FINNGEN) 1809 3.2e-33 0.0528 0.15 0.616
0.597-0.636
4.03
OR 95% CI: 2.59-6.28
Binary nominal
172.1 Melanomas of skin, dx or hx
Self-reported malignant melanoma
MGI Fixed threshold (5e-09) UKB GWAS (PHESANT) 9 4.3e-33 0.0133 0.0957 0.578
0.563-0.595
2.21
OR 95% CI: 1.45-3.35
Binary nominal
172.21 Basal cell carcinoma
Self-reported basal cell carcinoma
MGI P&T UKB GWAS (PHESANT) 72 1.7e-32 0.0256 0.108 0.591
0.575-0.607
2.5
OR 95% CI: 1.68-3.71
Binary nominal
174.1 Breast cancer [female]
Malignant neoplasm of breast
MGI lassosum UKB GWAS (FINNGEN) 2267 3.4e-32 0.0241 0.137 0.6
0.584-0.616
2.37
OR 95% CI: 1.54-3.65
Binary nominal
172.22 Squamous cell carcinoma
Cutaneous squamous cell carcinoma
MGI GWAS Hits GWAS Catalog (2019-05-03) 13 3.7e-32 0.0286 0.0974 0.599
0.579-0.618
3.51
OR 95% CI: 2.29-5.39
Binary nominal
185 Cancer of prostate
Prostate cancer (Schumacher FR et al. 2019)
MGI PRS-CS UKB GWAS (PheCode) 1119236 3.8e-32 0.035 0.15 0.614
0.595-0.633
2.32
OR 95% CI: 1.42-3.78
Binary nominal
172.1 Melanomas of skin, dx or hx
ICD-10 C43 Malignant melanoma of skin
MGI Fixed threshold (5e-06) UKB GWAS (ICD10) 37 5.3e-32 0.0123 0.0957 0.587
0.571-0.604
1.84
OR 95% CI: 1.17-2.9
Binary nominal
172.1 Melanomas of skin, dx or hx
Self-reported malignant melanoma
MGI GWAS Hits UKB GWAS (PHESANT) 10 5.4e-32 0.0133 0.0957 0.576
0.561-0.593
2.25
OR 95% CI: 1.48-3.42
Binary nominal
174.1 Breast cancer [female]
ER positive
MGI Fixed threshold (5e-07) Michailidou K et al. 2018 113 6.1e-32 0.02 0.137 0.599
0.583-0.615
2.49
OR 95% CI: 1.61-3.85
Binary nominal
172.1 Melanomas of skin, dx or hx
Malignant melanoma of skin
MGI Fixed threshold (5e-06) UKB GWAS (FINNGEN) 42 7.9e-32 0.0156 0.0957 0.584
0.568-0.6
2.49
OR 95% CI: 1.66-3.71
Binary nominal
185 Cancer of prostate
Self-reported prostate cancer
MGI Fixed threshold (5e-06) UKB GWAS (PHESANT) 56 2e-31 0.0398 0.15 0.609
0.591-0.628
3.37
OR 95% CI: 2.14-5.3
Binary nominal
172.21 Basal cell carcinoma
Self-reported basal cell carcinoma
MGI Fixed threshold (5e-06) UKB GWAS (PHESANT) 55 2.2e-31 0.0242 0.108 0.587
0.571-0.603
3.05
OR 95% CI: 2.1-4.42
Binary nominal
185 Cancer of prostate
ICD-10 C61 Malignant neoplasm of prostate
MGI PRS-CS UKB GWAS (ICD10) 1111493 2.3e-31 0.0256 0.15 0.612
0.593-0.63
2.09
OR 95% CI: 1.24-3.52
Binary nominal
172.21 Basal cell carcinoma
Self-reported basal cell carcinoma
MGI Fixed threshold (5e-07) UKB GWAS (PHESANT) 30 2.4e-31 0.0236 0.108 0.584
0.569-0.599
2.16
OR 95% CI: 1.42-3.28
Binary nominal
174.1 Breast cancer [female]
ER negative
UKB Fixed threshold (5e-09) Michailidou K et al. 2018 8 5e-31 0.0043 0.0826 0.536
0.528-0.544
1.77
OR 95% CI: 1.44-2.17
Binary nominal
172.22 Squamous cell carcinoma
Cutaneous squamous cell carcinoma
MGI Fixed threshold (5e-07) GWAS Catalog (2019-05-03) 14 6.4e-31 0.0291 0.0975 0.597
0.578-0.616
3.57
OR 95% CI: 2.33-5.47
Binary nominal
172.1 Melanomas of skin, dx or hx
ICD-10 C43 Malignant melanoma of skin
MGI Fixed threshold (5e-09) UKB GWAS (ICD10) 6 6.6e-31 0.0125 0.0958 0.575
0.559-0.592
2.26
OR 95% CI: 1.49-3.43
Binary nominal
185 Cancer of prostate
ICD-10 C61 Malignant neoplasm of prostate
MGI Fixed threshold (5e-05) UKB GWAS (ICD10) 256 6.9e-31 0.0476 0.15 0.61
0.591-0.629
2.22
OR 95% CI: 1.36-3.63
Binary nominal
185 Cancer of prostate
Self-reported prostate cancer
MGI P&T UKB GWAS (PHESANT) 78 9e-31 0.041 0.15 0.608
0.59-0.628
3.17
OR 95% CI: 1.98-5.06
Binary nominal
174.1 Breast cancer [female]
Breast cancer [female], Overall (Michailidou K et al. 2018)
MGI Fixed threshold (5e-07) UKB GWAS (PheCode) 64 1e-30 0.016 0.137 0.6
0.584-0.617
2.47
OR 95% CI: 1.59-3.83
Binary nominal
174.1 Breast cancer [female]
ER positive
MGI GWAS Hits Michailidou K et al. 2018 86 1.2e-30 0.0197 0.137 0.597
0.58-0.614
2.28
OR 95% CI: 1.46-3.56
Binary nominal
174.1 Breast cancer [female]
ER positive
MGI P&T Michailidou K et al. 2018 310 1.2e-30 0.024 0.137 0.597
0.58-0.612
2.98
OR 95% CI: 1.98-4.47
Binary nominal
172.22 Squamous cell carcinoma
Squamous cell carcinoma;Cutaneous squamous cell carcinoma (GWAS Catalog (2019-05-03))
MGI Fixed threshold (5e-05) Chahal HS et al. 2018 10 4e-30 0.0295 0.0976 0.589
0.57-0.61
4.54
OR 95% CI: 3.07-6.71
Binary nominal
172.22 Squamous cell carcinoma
Squamous cell carcinoma;Cutaneous squamous cell carcinoma (GWAS Catalog (2019-05-03))
MGI Fixed threshold (5e-06) Chahal HS et al. 2018 10 4e-30 0.0295 0.0976 0.589
0.57-0.61
4.54
OR 95% CI: 3.07-6.71
Binary nominal
172.22 Squamous cell carcinoma
Squamous cell carcinoma;Cutaneous squamous cell carcinoma (GWAS Catalog (2019-05-03))
MGI Fixed threshold (5e-07) Chahal HS et al. 2018 10 4e-30 0.0295 0.0976 0.589
0.57-0.61
4.54
OR 95% CI: 3.07-6.71
Binary nominal
172.22 Squamous cell carcinoma
Squamous cell carcinoma;Cutaneous squamous cell carcinoma (GWAS Catalog (2019-05-03))
MGI GWAS Hits Chahal HS et al. 2018 10 4e-30 0.0295 0.0976 0.589
0.57-0.61
4.54
OR 95% CI: 3.07-6.71
Binary nominal
172.1 Melanomas of skin, dx or hx
Self-reported malignant melanoma
MGI Fixed threshold (5e-06) UKB GWAS (PHESANT) 29 6.7e-30 0.0132 0.0958 0.579
0.564-0.596
1.81
OR 95% CI: 1.16-2.84
Binary nominal
153 Colorectal cancer
Cancer code, self-reported: large bowel cancer/colorectal cancer (UKB GWAS (PHESANT))
UKB Fixed threshold (5e-05) GWAS Catalog (2019-05-03) 27 1.3e-29 0.0135 0.0822 0.565
0.551-0.577
2.1
OR 95% CI: 1.53-2.89
Binary nominal
153 Colorectal cancer
Cancer code, self-reported: large bowel cancer/colorectal cancer (UKB GWAS (PHESANT))
UKB P&T GWAS Catalog (2019-05-03) 27 1.3e-29 0.0135 0.0822 0.565
0.551-0.577
2.1
OR 95% CI: 1.53-2.89
Binary nominal
185 Cancer of prostate
ICD-10 C61 Malignant neoplasm of prostate
MGI lassosum UKB GWAS (ICD10) 905 1.6e-29 0.0489 0.151 0.607
0.589-0.627
2.46
OR 95% CI: 1.5-4.01
Binary nominal
153 Colorectal cancer
Cancer code, self-reported: large bowel cancer/colorectal cancer (UKB GWAS (PHESANT))
UKB Fixed threshold (5e-06) GWAS Catalog (2019-05-03) 26 3.1e-29 0.0134 0.0822 0.564
0.551-0.577
2.1
OR 95% CI: 1.53-2.89
Binary nominal
174.1 Breast cancer [female]
Breast cancer [female], Overall (Michailidou K et al. 2018)
MGI Fixed threshold (5e-05) UKB GWAS (PheCode) 289 3.2e-29 0.018 0.137 0.597
0.581-0.613
1.93
OR 95% CI: 1.21-3.09
Binary nominal
172.1 Melanomas of skin, dx or hx
ICD-10 C43 Malignant melanoma of skin
MGI lassosum UKB GWAS (ICD10) 436 5.6e-29 0.0133 0.0959 0.565
0.549-0.583
1.93
OR 95% CI: 1.24-3
Binary nominal
185 Cancer of prostate
Self-reported prostate cancer
MGI Fixed threshold (5e-07) UKB GWAS (PHESANT) 32 7.3e-29 0.0374 0.151 0.607
0.59-0.626
2.83
OR 95% CI: 1.76-4.53
Binary nominal
174.1 Breast cancer [female]
Malignant neoplasm of breast
MGI P&T UKB GWAS (FINNGEN) 120 1.1e-28 0.0144 0.137 0.595
0.578-0.611
2.31
OR 95% CI: 1.47-3.61
Binary nominal
172.22 Squamous cell carcinoma
Cutaneous squamous cell carcinoma
MGI Fixed threshold (5e-09) GWAS Catalog (2019-05-03) 7 2.3e-28 0.0297 0.0977 0.593
0.573-0.613
3.74
OR 95% CI: 2.46-5.68
Binary nominal
172.22 Squamous cell carcinoma
Cutaneous squamous cell carcinoma
MGI P&T GWAS Catalog (2019-05-03) 7 2.3e-28 0.0297 0.0977 0.593
0.573-0.613
3.74
OR 95% CI: 2.46-5.68
Binary nominal
174.1 Breast cancer [female]
ER positive
MGI Fixed threshold (5e-09) Michailidou K et al. 2018 63 2.4e-28 0.0169 0.137 0.593
0.576-0.61
2.13
OR 95% CI: 1.36-3.34
Binary nominal
174.1 Breast cancer [female]
ICD-10 C50 Malignant neoplasm of breast
MGI lassosum UKB GWAS (ICD10) 4047 3e-28 0.0173 0.137 0.595
0.579-0.61
2.05
OR 95% CI: 1.3-3.24
Binary nominal
174.1 Breast cancer [female]
Breast cancer [female], Overall (Michailidou K et al. 2018)
MGI GWAS Hits UKB GWAS (PheCode) 41 3.6e-28 0.0127 0.137 0.595
0.577-0.612
1.8
OR 95% CI: 1.12-2.91
Binary nominal
172.1 Melanomas of skin, dx or hx
Ransohoff KJ et al. 2017
MGI Fixed threshold (5e-05) UKB GWAS (PheCode) 138 3.9e-28 0.0116 0.0959 0.586
0.571-0.602
2.14
OR 95% CI: 1.4-3.26
Binary nominal
174.1 Breast cancer [female]
Malignant neoplasm of breast
MGI Fixed threshold (5e-06) UKB GWAS (FINNGEN) 88 5.6e-28 0.014 0.137 0.594
0.577-0.611
2.03
OR 95% CI: 1.28-3.23
Binary nominal
174.1 Breast cancer [female]
ER negative
UKB Fixed threshold (5e-06) Michailidou K et al. 2018 35 8.5e-28 0.0033 0.0826 0.537
0.53-0.545
1.39
OR 95% CI: 1.11-1.74
Binary nominal
172.22 Squamous cell carcinoma
Squamous cell carcinoma;Cutaneous squamous cell carcinoma (GWAS Catalog (2019-05-03))
MGI P&T Chahal HS et al. 2018 6 1.2e-27 0.0315 0.0978 0.583
0.564-0.603
3.75
OR 95% CI: 2.49-5.64
Binary nominal
172.22 Squamous cell carcinoma
Squamous cell carcinoma;Cutaneous squamous cell carcinoma (GWAS Catalog (2019-05-03))
MGI Fixed threshold (5e-09) Chahal HS et al. 2018 5 2.4e-27 0.0313 0.0979 0.583
0.563-0.603
3.65
OR 95% CI: 2.41-5.53
Binary nominal
174.1 Breast cancer [female]
ER positive
MGI Fixed threshold (5e-05) Michailidou K et al. 2018 423 5.7e-27 0.0216 0.137 0.592
0.576-0.61
2.41
OR 95% CI: 1.56-3.71
Binary nominal
172.21 Basal cell carcinoma
Self-reported basal cell carcinoma
MGI Fixed threshold (5e-09) UKB GWAS (PHESANT) 14 6.4e-27 0.0174 0.108 0.577
0.562-0.592
2.9
OR 95% CI: 1.99-4.24
Binary nominal
174.1 Breast cancer [female]
Breast cancer [female], Overall (Michailidou K et al. 2018)
MGI PRS-CS UKB GWAS (PheCode) 1119237 2.1e-26 0.0189 0.137 0.59
0.573-0.607
1.79
OR 95% CI: 1.12-2.86
Binary nominal
153 Colorectal cancer
Cancer code, self-reported: large bowel cancer/colorectal cancer (UKB GWAS (PHESANT))
UKB Fixed threshold (5e-07) GWAS Catalog (2019-05-03) 22 8.7e-26 0.0118 0.0822 0.561
0.548-0.573
1.65
OR 95% CI: 1.17-2.34
Binary nominal
153 Colorectal cancer
Cancer code, self-reported: large bowel cancer/colorectal cancer (UKB GWAS (PHESANT))
UKB GWAS Hits GWAS Catalog (2019-05-03) 18 1.9e-25 0.0116 0.0822 0.561
0.548-0.573
1.79
OR 95% CI: 1.28-2.51
Binary nominal
172.1 Melanomas of skin, dx or hx
Malignant melanoma of skin
MGI Fixed threshold (5e-05) UKB GWAS (FINNGEN) 153 2.2e-25 0.0103 0.0959 0.577
0.562-0.593
2.4
OR 95% CI: 1.59-3.63
Binary nominal
172.21 Basal cell carcinoma
Self-reported basal cell carcinoma
MGI GWAS Hits UKB GWAS (PHESANT) 19 3e-25 0.0185 0.108 0.571
0.555-0.587
2.54
OR 95% CI: 1.72-3.74
Binary nominal
153 Colorectal cancer
Cancer code, self-reported: large bowel cancer/colorectal cancer (UKB GWAS (PHESANT))
UKB Fixed threshold (5e-09) GWAS Catalog (2019-05-03) 12 9.7e-25 0.0112 0.0822 0.56
0.547-0.572
1.79
OR 95% CI: 1.28-2.51
Binary nominal
174.1 Breast cancer [female]
Malignant neoplasm of breast
MGI GWAS Hits UKB GWAS (FINNGEN) 32 2e-24 0.0104 0.138 0.585
0.569-0.603
1.97
OR 95% CI: 1.24-3.14
Binary nominal
185 Cancer of prostate
Self-reported prostate cancer
MGI lassosum UKB GWAS (PHESANT) 1401 3.5e-24 0.0398 0.151 0.595
0.577-0.614
1.53
OR 95% CI: 0.88-2.66
Binary nominal
185 Cancer of prostate
Self-reported prostate cancer
MGI Fixed threshold (5e-09) UKB GWAS (PHESANT) 14 3.7e-24 0.035 0.151 0.591
0.573-0.61
1.67
OR 95% CI: 0.971-2.87
Binary nominal
172.21 Basal cell carcinoma
Self-reported basal cell carcinoma
MGI Fixed threshold (5e-05) UKB GWAS (PHESANT) 192 4e-24 0.0159 0.108 0.579
0.563-0.595
1.91
OR 95% CI: 1.25-2.92
Binary nominal
174.1 Breast cancer [female]
ICD-10 C50 Malignant neoplasm of breast
MGI Fixed threshold (5e-06) UKB GWAS (ICD10) 66 4.2e-24 0.0109 0.138 0.585
0.568-0.601
2.57
OR 95% CI: 1.68-3.95
Binary nominal
174.1 Breast cancer [female]
Malignant neoplasm of breast
MGI Fixed threshold (5e-05) UKB GWAS (FINNGEN) 233 5.4e-24 0.0119 0.138 0.586
0.57-0.603
1.82
OR 95% CI: 1.13-2.93
Binary nominal
174.1 Breast cancer [female]
Malignant neoplasm of breast
MGI Fixed threshold (5e-07) UKB GWAS (FINNGEN) 45 1.3e-23 0.01 0.138 0.585
0.568-0.602
2.22
OR 95% CI: 1.43-3.46
Binary nominal
174.1 Breast cancer [female]
ICD-10 C50 Malignant neoplasm of breast
MGI P&T UKB GWAS (ICD10) 42 1.5e-23 0.0127 0.138 0.584
0.568-0.601
1.43
OR 95% CI: 0.853-2.41
Binary nominal
185 Cancer of prostate
Self-reported prostate cancer
MGI GWAS Hits UKB GWAS (PHESANT) 21 3.3e-23 0.033 0.151 0.596
0.579-0.615
2.39
OR 95% CI: 1.41-4.03
Binary nominal
174.1 Breast cancer [female]
Breast cancer [female], Overall (Michailidou K et al. 2018)
MGI Fixed threshold (5e-09) UKB GWAS (PheCode) 24 4e-23 0.0091 0.138 0.583
0.566-0.601
2.37
OR 95% CI: 1.53-3.67
Binary nominal
174.1 Breast cancer [female]
ICD-10 C50 Malignant neoplasm of breast
MGI Fixed threshold (5e-07) UKB GWAS (ICD10) 29 4.2e-23 0.0103 0.138 0.582
0.565-0.599
1.85
OR 95% CI: 1.16-2.96
Binary nominal
174.1 Breast cancer [female]
Self-reported breast cancer
MGI Fixed threshold (5e-07) UKB GWAS (PHESANT) 33 1.2e-22 0.0096 0.138 0.581
0.564-0.598
2.17
OR 95% CI: 1.38-3.42
Binary nominal
185 Cancer of prostate
Self-reported prostate cancer
MGI Fixed threshold (5e-05) UKB GWAS (PHESANT) 203 1.3e-22 0.0295 0.152 0.591
0.573-0.611
1.82
OR 95% CI: 1.07-3.11
Binary nominal
174.1 Breast cancer [female]
Self-reported breast cancer
MGI GWAS Hits UKB GWAS (PHESANT) 22 2.3e-22 0.0081 0.138 0.579
0.561-0.597
2.32
OR 95% CI: 1.49-3.61
Binary nominal
172.22 Squamous cell carcinoma
Cutaneous squamous cell carcinoma
MGI Fixed threshold (5e-06) GWAS Catalog (2019-05-03) 17 4.7e-22 0.0203 0.0982 0.584
0.565-0.601
2.24
OR 95% CI: 1.35-3.71
Binary nominal
204.12 Lymphoid leukemia, chronic
Chronic lymphocytic leukemia
UKB Fixed threshold (5e-05) GWAS Catalog (2019-05-03) 44 5.4e-22 0.0948 0.0794 0.691
0.659-0.721
2.5
OR 95% CI: 1.03-6.06
Binary nominal
204.12 Lymphoid leukemia, chronic
Chronic lymphocytic leukemia
UKB Fixed threshold (5e-06) GWAS Catalog (2019-05-03) 43 7e-22 0.0943 0.0794 0.689
0.657-0.72
2.5
OR 95% CI: 1.03-6.06
Binary nominal
174.1 Breast cancer [female]
Self-reported breast cancer
MGI lassosum UKB GWAS (PHESANT) 30041 7.8e-22 0.0208 0.138 0.586
0.57-0.603
1.59
OR 95% CI: 0.962-2.62
Binary nominal
174.1 Breast cancer [female]
Self-reported breast cancer
MGI Fixed threshold (5e-09) UKB GWAS (PHESANT) 18 1.1e-21 0.0081 0.138 0.58
0.563-0.597
1.86
OR 95% CI: 1.15-2.99
Binary nominal
174.1 Breast cancer [female]
Self-reported breast cancer
MGI Fixed threshold (5e-06) UKB GWAS (PHESANT) 62 2.9e-21 0.0126 0.138 0.58
0.562-0.597
1.72
OR 95% CI: 1.06-2.79
Binary nominal
174.1 Breast cancer [female]
ICD-10 C50 Malignant neoplasm of breast
MGI Fixed threshold (5e-05) UKB GWAS (ICD10) 197 3e-21 0.0097 0.138 0.584
0.567-0.601
1.77
OR 95% CI: 1.08-2.9
Binary nominal
204.12 Lymphoid leukemia, chronic
Chronic lymphocytic leukemia
UKB Fixed threshold (5e-07) GWAS Catalog (2019-05-03) 40 3.1e-21 0.0949 0.0795 0.684
0.652-0.714
2.51
OR 95% CI: 1.04-6.07
Binary nominal
174.1 Breast cancer [female]
Self-reported breast cancer
MGI P&T UKB GWAS (PHESANT) 68 3.2e-21 0.013 0.138 0.58
0.563-0.597
1.54
OR 95% CI: 0.924-2.56
Binary nominal
174.1 Breast cancer [female]
Malignant neoplasm of breast
MGI PRS-CS UKB GWAS (FINNGEN) 1111495 3.7e-21 0.0176 0.138 0.581
0.564-0.597
2.17
OR 95% CI: 1.38-3.41
Binary nominal
185 Cancer of prostate
Self-reported prostate cancer
MGI PRS-CS UKB GWAS (PHESANT) 1111494 4.8e-21 0.021 0.152 0.591
0.573-0.609
2.85
OR 95% CI: 1.76-4.62
Binary nominal
174.1 Breast cancer [female]
ICD-10 C50 Malignant neoplasm of breast
MGI GWAS Hits UKB GWAS (ICD10) 20 6.4e-21 0.0083 0.138 0.576
0.559-0.593
1.91
OR 95% CI: 1.2-3.03
Binary nominal
172.22 Squamous cell carcinoma
Cutaneous squamous cell carcinoma
MGI Fixed threshold (5e-05) GWAS Catalog (2019-05-03) 18 8.6e-21 0.0178 0.0983 0.581
0.56-0.599
2.33
OR 95% CI: 1.44-3.77
Binary nominal
174.1 Breast cancer [female]
Malignant neoplasm of breast
MGI Fixed threshold (5e-09) UKB GWAS (FINNGEN) 21 3.3e-20 0.0076 0.138 0.575
0.558-0.592
2.38
OR 95% CI: 1.54-3.69
Binary nominal
204.12 Lymphoid leukemia, chronic
Chronic lymphocytic leukemia
UKB GWAS Hits GWAS Catalog (2019-05-03) 32 4.6e-20 0.0998 0.0795 0.675
0.64-0.707
4.11
OR 95% CI: 1.97-8.6
Binary nominal
174.1 Breast cancer [female]
ICD-10 C50 Malignant neoplasm of breast
MGI PRS-CS UKB GWAS (ICD10) 1111495 7.1e-20 0.0137 0.138 0.578
0.56-0.596
2.03
OR 95% CI: 1.29-3.2
Binary nominal
204.12 Lymphoid leukemia, chronic
Chronic lymphocytic leukemia
UKB P&T GWAS Catalog (2019-05-03) 27 1.7e-19 0.1021 0.0796 0.672
0.637-0.703
2.52
OR 95% CI: 1.04-6.08
Binary nominal
193 Thyroid cancer
Cancer code, self-reported: thyroid cancer (UKB GWAS (PHESANT))
MGI Fixed threshold (5e-05) GWAS Catalog (2019-05-03) 11 2.3e-19 0.0387 0.0811 0.63
0.601-0.658
3.26
OR 95% CI: 1.69-6.26
Binary nominal
193 Thyroid cancer
Cancer code, self-reported: thyroid cancer (UKB GWAS (PHESANT))
MGI Fixed threshold (5e-06) GWAS Catalog (2019-05-03) 11 2.3e-19 0.0387 0.0811 0.63
0.601-0.658
3.26
OR 95% CI: 1.69-6.26
Binary nominal
193 Thyroid cancer
Cancer code, self-reported: thyroid cancer (UKB GWAS (PHESANT))
MGI Fixed threshold (5e-07) GWAS Catalog (2019-05-03) 11 2.3e-19 0.0387 0.0811 0.63
0.601-0.658
3.26
OR 95% CI: 1.69-6.26
Binary nominal
172.21 Basal cell carcinoma
Self-reported basal cell carcinoma
MGI PRS-CS UKB GWAS (PHESANT) 1111490 4.2e-19 0.0146 0.109 0.575
0.559-0.591
1.42
OR 95% CI: 0.871-2.33
Binary nominal
174.1 Breast cancer [female]
ER negative
MGI PRS-CS Michailidou K et al. 2018 1119140 5e-19 0.0139 0.138 0.578
0.56-0.594
1.8
OR 95% CI: 1.13-2.88
Binary nominal
174.1 Breast cancer [female]
ER negative
MGI P&T Michailidou K et al. 2018 217 1e-18 0.0104 0.138 0.576
0.559-0.593
1.84
OR 95% CI: 1.14-2.97
Binary nominal
174.1 Breast cancer [female]
Self-reported breast cancer
MGI PRS-CS UKB GWAS (PHESANT) 1111495 1.3e-18 0.0139 0.138 0.576
0.56-0.592
1.6
OR 95% CI: 0.981-2.62
Binary nominal
189.2 Cancer of bladder
Bladder cancer;Urinary bladder cancer
UKB Fixed threshold (5e-05) GWAS Catalog (2019-05-03) 15 1.4e-18 0.0152 0.0821 0.571
0.555-0.588
2.91
OR 95% CI: 1.99-4.24
Binary nominal
189.2 Cancer of bladder
Bladder cancer;Urinary bladder cancer
UKB Fixed threshold (5e-06) GWAS Catalog (2019-05-03) 15 1.4e-18 0.0152 0.0821 0.571
0.555-0.588
2.91
OR 95% CI: 1.99-4.24
Binary nominal
189.2 Cancer of bladder
Bladder cancer;Urinary bladder cancer
UKB P&T GWAS Catalog (2019-05-03) 15 1.4e-18 0.0152 0.0821 0.571
0.555-0.588
2.91
OR 95% CI: 1.99-4.24
Binary nominal
174.1 Breast cancer [female]
Self-reported breast cancer
MGI Fixed threshold (5e-05) UKB GWAS (PHESANT) 210 1.8e-18 0.0117 0.138 0.576
0.559-0.593
1.53
OR 95% CI: 0.92-2.55
Binary nominal
174.1 Breast cancer [female]
ER negative
MGI Fixed threshold (5e-05) Michailidou K et al. 2018 392 1.8e-18 0.0093 0.138 0.575
0.557-0.592
2.15
OR 95% CI: 1.37-3.39
Binary nominal
193 Thyroid cancer
Cancer code, self-reported: thyroid cancer (UKB GWAS (PHESANT))
MGI GWAS Hits GWAS Catalog (2019-05-03) 10 2e-18 0.0374 0.0811 0.626
0.597-0.655
3.53
OR 95% CI: 1.87-6.66
Binary nominal
204.12 Lymphoid leukemia, chronic
Chronic lymphocytic leukemia
UKB Fixed threshold (5e-09) GWAS Catalog (2019-05-03) 23 3.2e-18 0.091 0.0798 0.667
0.632-0.699
2.52
OR 95% CI: 1.04-6.09
Binary nominal
172.1 Melanomas of skin, dx or hx
Self-reported malignant melanoma
MGI Fixed threshold (5e-05) UKB GWAS (PHESANT) 129 6e-18 0.0079 0.0962 0.565
0.549-0.582
1.61
OR 95% CI: 1.01-2.59
Binary nominal
172.3 Carcinoma in situ of skin
Diagnoses - main ICD10: D04 Carcinoma in situ of skin (UKB GWAS (ICD10))
MGI lassosum UKB GWAS (PheCode) 7 9.2e-18 0.0411 0.0923 0.569
0.541-0.595
3.77
OR 95% CI: 2.24-6.34
Binary nominal
189.2 Cancer of bladder
Bladder cancer;Urinary bladder cancer
UKB Fixed threshold (5e-07) GWAS Catalog (2019-05-03) 14 1.1e-17 0.0146 0.0821 0.569
0.553-0.586
3.07
OR 95% CI: 2.12-4.46
Binary nominal
193 Thyroid cancer
Cancer code, self-reported: thyroid cancer (UKB GWAS (PHESANT))
MGI Fixed threshold (5e-09) GWAS Catalog (2019-05-03) 9 1.4e-17 0.0387 0.0812 0.62
0.591-0.649
4.04
OR 95% CI: 2.21-7.39
Binary nominal
189.2 Cancer of bladder
Bladder cancer;Urinary bladder cancer
UKB Fixed threshold (5e-09) GWAS Catalog (2019-05-03) 12 1.7e-17 0.0132 0.0821 0.569
0.552-0.586
2.74
OR 95% CI: 1.86-4.03
Binary nominal
174.1 Breast cancer [female]
ICD-10 C50 Malignant neoplasm of breast
MGI Fixed threshold (5e-09) UKB GWAS (ICD10) 14 1.9e-17 0.0071 0.138 0.568
0.551-0.585
1.98
OR 95% CI: 1.25-3.13
Binary nominal
174.1 Breast cancer [female]
ER negative
MGI lassosum Michailidou K et al. 2018 18866 2.4e-17 0.0136 0.138 0.571
0.555-0.588
1.87
OR 95% CI: 1.16-3.01
Binary nominal
193 Thyroid cancer
Cancer code, self-reported: thyroid cancer (UKB GWAS (PHESANT))
MGI P&T GWAS Catalog (2019-05-03) 8 2.9e-17 0.0417 0.0812 0.618
0.587-0.647
5.14
OR 95% CI: 2.94-8.99
Binary nominal
172.1 Melanomas of skin, dx or hx
ICD-10 C43 Malignant melanoma of skin
MGI Fixed threshold (5e-05) UKB GWAS (ICD10) 164 5.1e-17 0.0075 0.0963 0.566
0.55-0.583
1.66
OR 95% CI: 1.04-2.66
Binary nominal
189.2 Cancer of bladder
Bladder cancer;Urinary bladder cancer
UKB GWAS Hits GWAS Catalog (2019-05-03) 13 5.1e-17 0.0146 0.0821 0.567
0.551-0.584
2.66
OR 95% CI: 1.79-3.93
Binary nominal
174.1 Breast cancer [female]
ER negative
MGI Fixed threshold (5e-06) Michailidou K et al. 2018 133 1.6e-16 0.0084 0.138 0.569
0.552-0.587
2.05
OR 95% CI: 1.3-3.23
Binary nominal
172.1 Melanomas of skin, dx or hx
Malignant melanoma of skin
MGI PRS-CS UKB GWAS (FINNGEN) 1111490 4.6e-16 0.0083 0.0964 0.568
0.552-0.584
2.09
OR 95% CI: 1.35-3.22
Binary nominal
191.1 Cancer of brain and nervous system
Glioma;Non-glioblastoma glioma;Glioma (high-grade)
UKB Fixed threshold (5e-07) GWAS Catalog (2019-05-03) 25 2.9e-15 0.0275 0.0811 0.628
0.595-0.659
3.29
OR 95% CI: 1.55-6.99
Binary nominal
191.1 Cancer of brain and nervous system
Glioma;Non-glioblastoma glioma;Glioma (high-grade)
UKB Fixed threshold (5e-05) GWAS Catalog (2019-05-03) 28 5.6e-15 0.0258 0.0811 0.625
0.592-0.656
3.65
OR 95% CI: 1.77-7.56
Binary nominal
191.1 Cancer of brain and nervous system
Glioma;Non-glioblastoma glioma;Glioma (high-grade)
UKB Fixed threshold (5e-06) GWAS Catalog (2019-05-03) 28 5.6e-15 0.0258 0.0811 0.625
0.592-0.656
3.65
OR 95% CI: 1.77-7.56
Binary nominal
172 Skin cancer
Self-reported skin cancer
MGI P&T UKB GWAS (PHESANT) 6 9.9e-15 0.0049 0.148 0.513
0.503-0.523
1.56
OR 95% CI: 1.12-2.16
Binary nominal
191.1 Cancer of brain and nervous system
Glioma;Non-glioblastoma glioma;Glioma (high-grade)
UKB P&T GWAS Catalog (2019-05-03) 19 1.3e-14 0.0315 0.0812 0.622
0.59-0.653
2.93
OR 95% CI: 1.34-6.41
Binary nominal
191.1 Cancer of brain and nervous system
Glioma;Non-glioblastoma glioma;Glioma (high-grade)
UKB GWAS Hits GWAS Catalog (2019-05-03) 23 1.4e-14 0.0276 0.0812 0.623
0.592-0.656
3.64
OR 95% CI: 1.76-7.53
Binary nominal
191.1 Cancer of brain and nervous system
Glioma;Non-glioblastoma glioma;Glioma (high-grade)
UKB Fixed threshold (5e-09) GWAS Catalog (2019-05-03) 20 3.8e-14 0.0309 0.0812 0.619
0.586-0.65
3.64
OR 95% CI: 1.76-7.52
Binary nominal
174.1 Breast cancer [female]
ER negative
MGI GWAS Hits Michailidou K et al. 2018 49 1e-13 0.01 0.139 0.564
0.547-0.58
1.72
OR 95% CI: 1.05-2.81
Binary nominal
187.2 Malignant neoplasm of testis
Testicular germ cell tumor;Testicular germ cell cancer
UKB Fixed threshold (5e-06) GWAS Catalog (2019-05-03) 44 1.3e-13 0.0527 0.0793 0.703
0.659-0.745
4.6
OR 95% CI: 1.75-12.1
Binary nominal
187.2 Malignant neoplasm of testis
Testicular germ cell tumor;Testicular germ cell cancer
UKB P&T GWAS Catalog (2019-05-03) 44 1.3e-13 0.0527 0.0793 0.703
0.659-0.745
4.6
OR 95% CI: 1.75-12.1
Binary nominal
174.1 Breast cancer [female]
ER negative
MGI Fixed threshold (5e-07) Michailidou K et al. 2018 14 2.1e-13 0.0071 0.139 0.556
0.538-0.571
1.69
OR 95% CI: 1.03-2.76
Binary nominal
172 Skin cancer
Self-reported skin cancer
MGI lassosum UKB GWAS (PHESANT) 6 2.2e-13 0.0049 0.148 0.471
0.461-0.48
1.57
OR 95% CI: 1.13-2.17
Binary nominal
174.1 Breast cancer [female]
ER negative
MGI Fixed threshold (5e-09) Michailidou K et al. 2018 31 2.8e-13 0.0081 0.139 0.561
0.544-0.578
1.62
OR 95% CI: 0.984-2.68
Binary nominal
187.2 Malignant neoplasm of testis
Testicular germ cell tumor;Testicular germ cell cancer
UKB Fixed threshold (5e-07) GWAS Catalog (2019-05-03) 42 3.9e-13 0.0516 0.0795 0.699
0.656-0.742
5.34
OR 95% CI: 2.12-13.4
Binary nominal
187.2 Malignant neoplasm of testis
Testicular germ cell tumor;Testicular germ cell cancer
UKB GWAS Hits GWAS Catalog (2019-05-03) 40 4.1e-13 0.0511 0.0795 0.698
0.656-0.74
4.6
OR 95% CI: 1.75-12.1
Binary nominal
187.2 Malignant neoplasm of testis
Testicular germ cell tumor;Testicular germ cell cancer
UKB Fixed threshold (5e-05) GWAS Catalog (2019-05-03) 46 5e-13 0.0505 0.0794 0.697
0.652-0.74
4.6
OR 95% CI: 1.75-12.1
Binary nominal
191.11 Cancer of brain
Glioblastoma
UKB Fixed threshold (5e-05) GWAS Catalog (2019-05-03) 15 2.3e-12 0.0465 0.0812 0.618
0.582-0.652
3.76
OR 95% CI: 1.82-7.79
Binary nominal
189.2 Cancer of bladder
Bladder cancer;Urinary bladder cancer
MGI Fixed threshold (5e-09) GWAS Catalog (2019-05-03) 12 2.5e-12 0.0033 0.0916 0.574
0.552-0.596
1.95
OR 95% CI: 1.11-3.42
Binary nominal
172.1 Melanomas of skin, dx or hx
ICD-10 C43 Malignant melanoma of skin
MGI PRS-CS UKB GWAS (ICD10) 1109519 3e-12 0.0037 0.0965 0.556
0.541-0.571
1.88
OR 95% CI: 1.2-2.95
Binary nominal
174.1 Breast cancer [female]
ER negative
UKB Fixed threshold (5e-05) Michailidou K et al. 2018 158 3.1e-12 0.002 0.0827 0.526
0.518-0.533
1.21
OR 95% CI: 0.952-1.54
Binary nominal
174.1 Breast cancer [female]
ER negative
MGI Fixed threshold (5e-07) Michailidou K et al. 2018 73 6.2e-12 0.0084 0.139 0.557
0.54-0.574
1.62
OR 95% CI: 0.98-2.67
Binary nominal
191.11 Cancer of brain
Glioblastoma
UKB Fixed threshold (5e-06) GWAS Catalog (2019-05-03) 14 7.1e-12 0.0443 0.0813 0.616
0.581-0.649
3.03
OR 95% CI: 1.38-6.65
Binary nominal
189.2 Cancer of bladder
Bladder cancer;Urinary bladder cancer
MGI GWAS Hits GWAS Catalog (2019-05-03) 13 8.1e-12 0.0036 0.0917 0.572
0.55-0.594
1.47
OR 95% CI: 0.779-2.77
Binary nominal
189.2 Cancer of bladder
Bladder cancer;Urinary bladder cancer
MGI P&T GWAS Catalog (2019-05-03) 13 8.1e-12 0.0036 0.0917 0.572
0.55-0.594
1.47
OR 95% CI: 0.779-2.77
Binary nominal
191.11 Cancer of brain
Glioblastoma
UKB P&T GWAS Catalog (2019-05-03) 5 1.1e-11 0.0529 0.0813 0.606
0.568-0.642
4.15
OR 95% CI: 2.04-8.41
Binary nominal
187.2 Malignant neoplasm of testis
Testicular germ cell tumor;Testicular germ cell cancer
UKB Fixed threshold (5e-09) GWAS Catalog (2019-05-03) 31 1.2e-11 0.045 0.08 0.681
0.634-0.723
5.36
OR 95% CI: 2.13-13.5
Binary nominal
174.1 Breast cancer [female]
ER negative
MGI GWAS Hits Michailidou K et al. 2018 10 1.6e-11 0.0072 0.139 0.55
0.533-0.566
1.88
OR 95% CI: 1.17-3.03
Binary nominal
174.1 Breast cancer [female]
ER negative
MGI lassosum Michailidou K et al. 2018 270 1.6e-11 0.0061 0.139 0.546
0.529-0.562
2.11
OR 95% CI: 1.34-3.33
Binary nominal
189.2 Cancer of bladder
Bladder cancer;Urinary bladder cancer
MGI Fixed threshold (5e-07) GWAS Catalog (2019-05-03) 14 1.6e-11 0.0031 0.0917 0.571
0.55-0.594
1.32
OR 95% CI: 0.684-2.56
Binary nominal
189.2 Cancer of bladder
Bladder cancer;Urinary bladder cancer
MGI Fixed threshold (5e-05) GWAS Catalog (2019-05-03) 15 1.9e-11 0.0034 0.0917 0.572
0.55-0.594
2.12
OR 95% CI: 1.22-3.66
Binary nominal
189.2 Cancer of bladder
Bladder cancer;Urinary bladder cancer
MGI Fixed threshold (5e-06) GWAS Catalog (2019-05-03) 15 1.9e-11 0.0034 0.0917 0.572
0.55-0.594
2.12
OR 95% CI: 1.22-3.66
Binary nominal
172.1 Melanomas of skin, dx or hx
Ransohoff KJ et al. 2017
MGI PRS-CS UKB GWAS (PheCode) 1119238 2e-11 0.0069 0.0965 0.555
0.54-0.573
1.64
OR 95% CI: 1.01-2.66
Binary nominal
172.3 Carcinoma in situ of skin
Diagnoses - main ICD10: D04 Carcinoma in situ of skin (UKB GWAS (ICD10))
MGI Fixed threshold (5e-07) UKB GWAS (PheCode) 5 3.9e-11 0.0262 0.093 0.557
0.531-0.582
2.45
OR 95% CI: 1.34-4.45
Binary nominal
172.3 Carcinoma in situ of skin
Diagnoses - main ICD10: D04 Carcinoma in situ of skin (UKB GWAS (ICD10))
MGI P&T UKB GWAS (PheCode) 5 3.9e-11 0.0262 0.093 0.557
0.531-0.582
2.45
OR 95% CI: 1.34-4.45
Binary nominal
174.1 Breast cancer [female]
ER negative
MGI P&T Michailidou K et al. 2018 9 6.5e-11 0.0074 0.139 0.548
0.53-0.564
1.88
OR 95% CI: 1.18-2.99
Binary nominal
182 Malignant neoplasm of uterus
Endometrial cancer;Endometrial cancer (endometrioid histology);Endometrial endometrioid carcinoma;Endometrial cancer (Non-endometrioid histology)
UKB GWAS Hits GWAS Catalog (2019-05-03) 18 6.9e-11 0.0082 0.082 0.576
0.553-0.6
2.12
OR 95% CI: 1.17-3.84
Binary nominal
193 Thyroid cancer
Cancer code, self-reported: thyroid cancer (UKB GWAS (PHESANT))
MGI lassosum UKB GWAS (PheCode) 954 1.3e-10 0.0136 0.0819 0.578
0.548-0.607
3.21
OR 95% CI: 1.67-6.15
Binary nominal
182 Malignant neoplasm of uterus
Endometrial cancer;Endometrial cancer (endometrioid histology);Endometrial endometrioid carcinoma;Endometrial cancer (Non-endometrioid histology)
UKB Fixed threshold (5e-09) GWAS Catalog (2019-05-03) 11 1.5e-10 0.008 0.082 0.577
0.552-0.601
1.32
OR 95% CI: 0.64-2.72
Binary nominal
165.1 Cancer of bronchus; lung
Lung cancer in ever smokers;Squamous cell lung carcinoma;Lung adenocarcinoma;Lung cancer;Lung cancer in never smokers;Familial squamous cell lung carcinoma;Familial lung adenocarcinoma;Familial lung cancer;Small cell lung carcinoma
UKB P&T GWAS Catalog (2019-05-03) 19 1.7e-10 0.0076 0.0824 0.552
0.534-0.569
1.94
OR 95% CI: 1.22-3.1
Binary nominal
202.2 Non-Hodgkin lymphoma
Diffuse large B cell lymphoma;Follicular lymphoma
UKB P&T GWAS Catalog (2019-05-03) 10 2e-10 0.0082 0.082 0.547
0.527-0.566
2.05
OR 95% CI: 1.24-3.4
Binary nominal
191.11 Cancer of brain
Glioblastoma
UKB Fixed threshold (5e-07) GWAS Catalog (2019-05-03) 12 2.2e-10 0.05 0.0815 0.605
0.569-0.639
3.38
OR 95% CI: 1.59-7.2
Binary nominal
191.11 Cancer of brain
Glioblastoma
UKB GWAS Hits GWAS Catalog (2019-05-03) 12 2.2e-10 0.05 0.0815 0.605
0.569-0.639
3.38
OR 95% CI: 1.59-7.2
Binary nominal
182 Malignant neoplasm of uterus
Endometrial cancer;Endometrial cancer (endometrioid histology);Endometrial endometrioid carcinoma;Endometrial cancer (Non-endometrioid histology)
UKB P&T GWAS Catalog (2019-05-03) 20 2.3e-10 0.0084 0.082 0.572
0.549-0.596
2.6
OR 95% CI: 1.5-4.51
Binary nominal
191.11 Cancer of brain
Glioblastoma
UKB Fixed threshold (5e-09) GWAS Catalog (2019-05-03) 11 2.4e-10 0.0481 0.0815 0.605
0.57-0.639
3.02
OR 95% CI: 1.37-6.64
Binary nominal
193 Thyroid cancer
Cancer code, self-reported: thyroid cancer (UKB GWAS (PHESANT))
UKB Fixed threshold (5e-09) GWAS Catalog (2019-05-03) 9 2.6e-10 0.0517 0.0802 0.634
0.586-0.679
5.04
OR 95% CI: 2.15-11.8
Binary nominal
165.1 Cancer of bronchus; lung
Lung cancer in ever smokers;Squamous cell lung carcinoma;Lung adenocarcinoma;Lung cancer;Lung cancer in never smokers;Familial squamous cell lung carcinoma;Familial lung adenocarcinoma;Familial lung cancer;Small cell lung carcinoma
UKB Fixed threshold (5e-09) GWAS Catalog (2019-05-03) 18 2.8e-10 0.0074 0.0824 0.551
0.533-0.568
1.94
OR 95% CI: 1.22-3.1
Binary nominal
193 Thyroid cancer
Cancer code, self-reported: thyroid cancer (UKB GWAS (PHESANT))
UKB Fixed threshold (5e-05) GWAS Catalog (2019-05-03) 11 3.1e-10 0.0532 0.0803 0.639
0.592-0.682
4.41
OR 95% CI: 1.81-10.7
Binary nominal
193 Thyroid cancer
Cancer code, self-reported: thyroid cancer (UKB GWAS (PHESANT))
UKB Fixed threshold (5e-06) GWAS Catalog (2019-05-03) 11 3.1e-10 0.0532 0.0803 0.639
0.592-0.682
4.41
OR 95% CI: 1.81-10.7
Binary nominal
193 Thyroid cancer
Cancer code, self-reported: thyroid cancer (UKB GWAS (PHESANT))
UKB Fixed threshold (5e-07) GWAS Catalog (2019-05-03) 11 3.1e-10 0.0532 0.0803 0.639
0.592-0.682
4.41
OR 95% CI: 1.81-10.7
Binary nominal
193 Thyroid cancer
Cancer code, self-reported: thyroid cancer (UKB GWAS (PHESANT))
UKB GWAS Hits GWAS Catalog (2019-05-03) 10 5.1e-10 0.053 0.0803 0.636
0.589-0.682
4.4
OR 95% CI: 1.81-10.7
Binary nominal
172 Skin cancer
Self-reported skin cancer
MGI Fixed threshold (5e-07) UKB GWAS (PHESANT) 5 7.4e-10 0.0028 0.148 0.5
0.489-0.511
1.56
OR 95% CI: 1.12-2.16
Binary nominal
174.1 Breast cancer [female]
ER negative
MGI Fixed threshold (5e-09) Michailidou K et al. 2018 8 8.4e-10 0.0055 0.139 0.543
0.525-0.56
1.74
OR 95% CI: 1.08-2.81
Binary nominal
193 Thyroid cancer
Cancer code, self-reported: thyroid cancer (UKB GWAS (PHESANT))
UKB P&T GWAS Catalog (2019-05-03) 5 1.3e-9 0.0581 0.0804 0.628
0.582-0.675
4.41
OR 95% CI: 1.81-10.7
Binary nominal
172.1 Melanomas of skin, dx or hx
Self-reported malignant melanoma
MGI PRS-CS UKB GWAS (PHESANT) 1111490 1.8e-9 0.0051 0.0966 0.547
0.531-0.563
1.94
OR 95% CI: 1.25-3.02
Binary nominal
174.1 Breast cancer [female]
ER negative
MGI Fixed threshold (5e-06) Michailidou K et al. 2018 35 1.8e-9 0.004 0.139 0.546
0.528-0.561
1.99
OR 95% CI: 1.25-3.18
Binary nominal
204.12 Lymphoid leukemia, chronic
Chronic lymphocytic leukemia
MGI Fixed threshold (5e-06) GWAS Catalog (2019-05-03) 43 4.7e-9 0.0545 0.0775 0.698
0.623-0.766
15.2
OR 95% CI: 5.32-43.4
Binary nominal
204.12 Lymphoid leukemia, chronic
Chronic lymphocytic leukemia
MGI Fixed threshold (5e-05) GWAS Catalog (2019-05-03) 44 6.1e-9 0.0558 0.0776 0.696
0.621-0.764
12.9
OR 95% CI: 4.45-37.6
Binary nominal
204.12 Lymphoid leukemia, chronic
Chronic lymphocytic leukemia
MGI P&T GWAS Catalog (2019-05-03) 44 6.1e-9 0.0558 0.0776 0.696
0.621-0.764
12.9
OR 95% CI: 4.45-37.6
Binary nominal
202.2 Non-Hodgkin lymphoma
Diffuse large B cell lymphoma;Follicular lymphoma
UKB Fixed threshold (5e-05) GWAS Catalog (2019-05-03) 18 6.4e-9 0.0066 0.082 0.55
0.53-0.571
2.28
OR 95% CI: 1.4-3.7
Binary nominal
204.12 Lymphoid leukemia, chronic
Chronic lymphocytic leukemia
MGI Fixed threshold (5e-07) GWAS Catalog (2019-05-03) 40 7.6e-9 0.0554 0.0778 0.698
0.624-0.768
12.5
OR 95% CI: 4.36-36.1
Binary nominal
165.1 Cancer of bronchus; lung
Lung cancer in ever smokers;Squamous cell lung carcinoma;Lung adenocarcinoma;Lung cancer;Lung cancer in never smokers;Familial squamous cell lung carcinoma;Familial lung adenocarcinoma;Familial lung cancer;Small cell lung carcinoma
UKB GWAS Hits GWAS Catalog (2019-05-03) 21 9.2e-9 0.0054 0.0824 0.543
0.526-0.562
0.852
OR 95% CI: 0.437-1.66
Binary nominal
153.2 Colon cancer
Cancer code, self-reported: colon cancer/sigmoid cancer (UKB GWAS (PHESANT))
MGI PRS-CS UKB GWAS (PheCode) 1119238 9.8e-9 0.0023 0.0827 0.569
0.539-0.599
3.85
OR 95% CI: 2.19-6.77
Binary nominal
204.12 Lymphoid leukemia, chronic
Chronic lymphocytic leukemia
MGI GWAS Hits GWAS Catalog (2019-05-03) 32 1.3e-8 0.0458 0.0779 0.696
0.628-0.765
11.3
OR 95% CI: 3.76-33.9
Binary nominal
202.2 Non-Hodgkin lymphoma
Diffuse large B cell lymphoma;Follicular lymphoma
UKB GWAS Hits GWAS Catalog (2019-05-03) 12 1.9e-8 0.0056 0.0821 0.541
0.521-0.561
2.05
OR 95% CI: 1.24-3.4
Binary nominal
182 Malignant neoplasm of uterus
Endometrial cancer;Endometrial cancer (endometrioid histology);Endometrial endometrioid carcinoma;Endometrial cancer (Non-endometrioid histology)
UKB Fixed threshold (5e-07) GWAS Catalog (2019-05-03) 28 2e-8 0.0064 0.0822 0.562
0.539-0.585
1.32
OR 95% CI: 0.641-2.73
Binary nominal
157 Pancreatic cancer
UKB GWAS Hits GWAS Catalog (2019-05-03) 17 2.4e-8 0.0132 0.082 0.589
0.559-0.622
2.58
OR 95% CI: 1.19-5.57
Binary nominal
193 Thyroid cancer
Cancer code, self-reported: thyroid cancer (UKB GWAS (PHESANT))
MGI P&T UKB GWAS (PheCode) 5 2.7e-8 0.0157 0.0822 0.569
0.538-0.598
1.65
OR 95% CI: 0.708-3.83
Binary nominal
202.2 Non-Hodgkin lymphoma
Diffuse large B cell lymphoma;Follicular lymphoma
UKB Fixed threshold (5e-09) GWAS Catalog (2019-05-03) 11 2.9e-8 0.0059 0.0821 0.54
0.52-0.56
1.6
OR 95% CI: 0.914-2.8
Binary nominal
10001 Any Cancer
MGI Fixed threshold (5e-06) UKB GWAS (PheCode) 47 3.4e-8 0.0023 0.182 0.529
0.518-0.54
1.22
OR 95% CI: 0.864-1.73
Binary nominal
204.12 Lymphoid leukemia, chronic
Chronic lymphocytic leukemia
MGI Fixed threshold (5e-09) GWAS Catalog (2019-05-03) 23 5.1e-8 0.0371 0.0784 0.688
0.618-0.758
11.1
OR 95% CI: 3.68-33.4
Binary nominal
172.3 Carcinoma in situ of skin
Diagnoses - main ICD10: D04 Carcinoma in situ of skin (UKB GWAS (ICD10))
MGI Fixed threshold (5e-06) UKB GWAS (PheCode) 14 6.2e-8 0.0124 0.0934 0.556
0.531-0.583
2.47
OR 95% CI: 1.35-4.5
Binary nominal
172 Skin cancer
Self-reported skin cancer
MGI Fixed threshold (5e-06) UKB GWAS (PHESANT) 15 1.2e-7 0.0023 0.148 0.509
0.499-0.52
1.52
OR 95% CI: 1.08-2.14
Binary nominal
182 Malignant neoplasm of uterus
Endometrial cancer;Endometrial cancer (endometrioid histology);Endometrial endometrioid carcinoma;Endometrial cancer (Non-endometrioid histology)
UKB Fixed threshold (5e-05) GWAS Catalog (2019-05-03) 34 1.2e-7 0.0039 0.0822 0.559
0.535-0.581
1.64
OR 95% CI: 0.846-3.17
Binary nominal
182 Malignant neoplasm of uterus
Endometrial cancer;Endometrial cancer (endometrioid histology);Endometrial endometrioid carcinoma;Endometrial cancer (Non-endometrioid histology)
UKB Fixed threshold (5e-06) GWAS Catalog (2019-05-03) 34 1.2e-7 0.0039 0.0822 0.559
0.535-0.581
1.64
OR 95% CI: 0.846-3.17
Binary nominal
10001 Any Cancer
MGI lassosum UKB GWAS (PheCode) 179 1.5e-7 0.0037 0.182 0.523
0.512-0.535
1.61
OR 95% CI: 1.14-2.27
Binary nominal
202 Cancer of other lymphoid, histiocytic tissue
Marginal zone lymphoma;Waldenström macroglobulinemia / lymphoplasmacytic lymphoma
UKB Fixed threshold (5e-07) GWAS Catalog (2019-05-03) 5 1.7e-7 0.0011 0.0822 0.49
0.476-0.505
1.97
OR 95% CI: 1.25-3.12
Binary nominal
202 Cancer of other lymphoid, histiocytic tissue
Marginal zone lymphoma;Waldenström macroglobulinemia / lymphoplasmacytic lymphoma
UKB P&T GWAS Catalog (2019-05-03) 5 1.7e-7 0.0011 0.0822 0.49
0.476-0.505
1.97
OR 95% CI: 1.25-3.12
Binary nominal
202 Cancer of other lymphoid, histiocytic tissue
Marginal zone lymphoma;Waldenström macroglobulinemia / lymphoplasmacytic lymphoma
UKB Fixed threshold (5e-05) GWAS Catalog (2019-05-03) 7 1.8e-7 0.0011 0.0822 0.493
0.479-0.508
2.13
OR 95% CI: 1.38-3.28
Binary nominal
202 Cancer of other lymphoid, histiocytic tissue
Marginal zone lymphoma;Waldenström macroglobulinemia / lymphoplasmacytic lymphoma
UKB Fixed threshold (5e-06) GWAS Catalog (2019-05-03) 7 1.8e-7 0.0011 0.0822 0.493
0.479-0.508
2.13
OR 95% CI: 1.38-3.28
Binary nominal
184.11 Malignant neoplasm of ovary
Invasive epithelial ovarian cancer
UKB PRS-CS Phelan CM et al. 2017 1115189 2.3e-7 0.0119 0.0823 0.568
0.542-0.595
1.76
OR 95% CI: 0.838-3.7
Binary nominal
202.2 Non-Hodgkin lymphoma
Diffuse large B cell lymphoma;Follicular lymphoma
UKB Fixed threshold (5e-06) GWAS Catalog (2019-05-03) 16 2.5e-7 0.0058 0.0821 0.539
0.519-0.559
1.6
OR 95% CI: 0.913-2.8
Binary nominal
202.2 Non-Hodgkin lymphoma
Diffuse large B cell lymphoma;Follicular lymphoma
UKB Fixed threshold (5e-07) GWAS Catalog (2019-05-03) 16 2.5e-7 0.0058 0.0821 0.539
0.519-0.559
1.6
OR 95% CI: 0.913-2.8
Binary nominal
157 Pancreatic cancer
UKB Fixed threshold (5e-09) GWAS Catalog (2019-05-03) 10 3.3e-7 0.0145 0.0822 0.579
0.548-0.611
1.64
OR 95% CI: 0.655-4.12
Binary nominal
157 Pancreatic cancer
UKB P&T GWAS Catalog (2019-05-03) 10 3.3e-7 0.0145 0.0822 0.579
0.548-0.611
1.64
OR 95% CI: 0.655-4.12
Binary nominal
157 Pancreatic cancer
UKB Fixed threshold (5e-07) GWAS Catalog (2019-05-03) 21 4.9e-7 0.009 0.0822 0.588
0.556-0.621
2.57
OR 95% CI: 1.19-5.55
Binary nominal
189.2 Cancer of bladder
Bladder cancer;Urinary bladder cancer (GWAS Catalog (2019-05-03))
MGI Fixed threshold (5e-07) UKB GWAS (PheCode) 8 5.1e-7 0.0011 0.0919 0.548
0.526-0.569
1.68
OR 95% CI: 0.929-3.04
Binary nominal
184.11 Malignant neoplasm of ovary
Invasive epithelial ovarian cancer
UKB Fixed threshold (5e-07) Phelan CM et al. 2017 23 7e-7 0.0038 0.0823 0.567
0.539-0.595
1.97
OR 95% CI: 0.971-4
Binary nominal
153 Colorectal cancer
Cancer code, self-reported: large bowel cancer/colorectal cancer (UKB GWAS (PHESANT))
MGI Fixed threshold (5e-09) Huyghe JR et al. 2019 56 9.3e-7 0.0127 0.0827 0.559
0.532-0.584
1.89
OR 95% CI: 0.995-3.58
Binary nominal
184.11 Malignant neoplasm of ovary
Invasive epithelial ovarian cancer
UKB GWAS Hits Phelan CM et al. 2017 16 1.1e-6 0.0056 0.0824 0.567
0.539-0.595
1.76
OR 95% CI: 0.839-3.69
Binary nominal
172.21 Basal cell carcinoma
Self-reported rodent ulcer
MGI lassosum UKB GWAS (PHESANT) 2231 1.2e-6 0.0028 0.109 0.521
0.506-0.536
2.44
OR 95% CI: 1.65-3.62
Binary nominal
193 Thyroid cancer
Malignant neoplasm of thyroid gland
MGI lassosum UKB GWAS (FINNGEN) 656 1.7e-6 0.011 0.0823 0.565
0.535-0.595
1.91
OR 95% CI: 0.861-4.22
Binary nominal
184.11 Malignant neoplasm of ovary
Invasive epithelial ovarian cancer
UKB Fixed threshold (5e-09) Phelan CM et al. 2017 13 2e-6 0.006 0.0824 0.561
0.533-0.589
1.34
OR 95% CI: 0.585-3.08
Binary nominal
153.2 Colon cancer
Cancer code, self-reported: colon cancer/sigmoid cancer (UKB GWAS (PHESANT))
MGI Fixed threshold (5e-06) UKB GWAS (PheCode) 20 2.4e-6 0.0013 0.083 0.559
0.532-0.586
1.6
OR 95% CI: 0.733-3.51
Binary nominal
193 Thyroid cancer
Malignant neoplasm of thyroid gland
MGI Fixed threshold (5e-06) UKB GWAS (FINNGEN) 11 3.4e-6 0.0171 0.0824 0.56
0.53-0.59
2.42
OR 95% CI: 1.17-4.98
Binary nominal
193 Thyroid cancer
Malignant neoplasm of thyroid gland
MGI P&T UKB GWAS (FINNGEN) 11 3.4e-6 0.0171 0.0824 0.56
0.53-0.59
2.42
OR 95% CI: 1.17-4.98
Binary nominal
165.1 Cancer of bronchus; lung
Lung cancer in ever smokers;Squamous cell lung carcinoma;Lung adenocarcinoma;Lung cancer;Lung cancer in never smokers;Familial squamous cell lung carcinoma;Familial lung adenocarcinoma;Familial lung cancer;Small cell lung carcinoma
UKB Fixed threshold (5e-07) GWAS Catalog (2019-05-03) 58 3.8e-6 0.0017 0.0825 0.531
0.514-0.549
1.58
OR 95% CI: 0.948-2.63
Binary nominal
184.11 Malignant neoplasm of ovary
Invasive epithelial ovarian cancer
UKB Fixed threshold (5e-06) Phelan CM et al. 2017 54 3.8e-6 0.0026 0.0824 0.566
0.538-0.594
1.34
OR 95% CI: 0.583-3.07
Binary nominal
174.1 Breast cancer [female]
ER negative
MGI PRS-CS Michailidou K et al. 2018 1115376 4.2e-6 0.0022 0.139 0.539
0.52-0.556
1.51
OR 95% CI: 0.907-2.51
Binary nominal
153.2 Colon cancer
Cancer code, self-reported: colon cancer/sigmoid cancer (UKB GWAS (PHESANT))
MGI lassosum UKB GWAS (PheCode) 150 4.9e-6 0.0023 0.083 0.567
0.54-0.594
1.17
OR 95% CI: 0.477-2.87
Binary nominal
153 Colorectal cancer
Cancer code, self-reported: large bowel cancer/colorectal cancer (UKB GWAS (PHESANT))
MGI Fixed threshold (5e-07) Huyghe JR et al. 2019 81 5.4e-6 0.0157 0.0828 0.553
0.525-0.577
3.04
OR 95% CI: 1.79-5.17
Binary nominal
153 Colorectal cancer
Cancer code, self-reported: large bowel cancer/colorectal cancer (UKB GWAS (PHESANT))
MGI P&T Huyghe JR et al. 2019 81 5.4e-6 0.0157 0.0828 0.553
0.525-0.577
3.04
OR 95% CI: 1.79-5.17
Binary nominal
153 Colorectal cancer
Cancer code, self-reported: large bowel cancer/colorectal cancer (UKB GWAS (PHESANT))
MGI Fixed threshold (5e-05) Huyghe JR et al. 2019 87 6.9e-6 0.0155 0.0828 0.552
0.525-0.576
2.39
OR 95% CI: 1.33-4.27
Binary nominal
153 Colorectal cancer
Cancer code, self-reported: large bowel cancer/colorectal cancer (UKB GWAS (PHESANT))
MGI Fixed threshold (5e-06) Huyghe JR et al. 2019 85 7e-6 0.0152 0.0828 0.551
0.525-0.576
2.72
OR 95% CI: 1.56-4.73
Binary nominal
184.11 Malignant neoplasm of ovary
Serous invasive ovarian cancer
UKB GWAS Hits Phelan CM et al. 2017 21 8.4e-6 0.005 0.0824 0.552
0.523-0.581
1.76
OR 95% CI: 0.839-3.69
Binary nominal
184.11 Malignant neoplasm of ovary
Invasive epithelial ovarian cancer
UKB P&T Phelan CM et al. 2017 12 8.6e-6 0.0065 0.0824 0.558
0.53-0.586
1.55
OR 95% CI: 0.71-3.38
Binary nominal
184.11 Malignant neoplasm of ovary
Serous invasive ovarian cancer
UKB Fixed threshold (5e-09) Phelan CM et al. 2017 19 1.5e-5 0.0044 0.0824 0.549
0.52-0.579
1.55
OR 95% CI: 0.709-3.38
Binary nominal
204.4 Multiple myeloma
(hyperdiploidy);Multiple myeloma (IgH translocation);Multiple myeloma;Multiple myeloma and monoclonal gammopathy
UKB GWAS Hits GWAS Catalog (2019-05-03) 22 2e-5 0.0268 0.0818 0.577
0.537-0.617
2.2
OR 95% CI: 0.855-5.66
Binary nominal
153 Colorectal cancer
Cancer code, self-reported: large bowel cancer/colorectal cancer (UKB GWAS (PHESANT))
MGI GWAS Hits Huyghe JR et al. 2019 74 2.1e-5 0.0152 0.0828 0.55
0.522-0.574
2.2
OR 95% CI: 1.21-4
Binary nominal
10001 Any Cancer
MGI Fixed threshold (5e-07) UKB GWAS (PheCode) 18 2.5e-5 0.0024 0.182 0.519
0.507-0.53
1.25
OR 95% CI: 0.87-1.78
Binary nominal
184.11 Malignant neoplasm of ovary
Serous invasive ovarian cancer
UKB Fixed threshold (5e-06) Phelan CM et al. 2017 58 2.6e-5 0.0032 0.0825 0.556
0.529-0.584
1.55
OR 95% CI: 0.709-3.38
Binary nominal
10001 Any Cancer
MGI P&T UKB GWAS (PheCode) 15 2.7e-5 0.003 0.182 0.517
0.506-0.527
1.42
OR 95% CI: 1-2.02
Binary nominal
187.2 Malignant neoplasm of testis
Self-reported testicular cancer
MGI Fixed threshold (5e-07) UKB GWAS (PHESANT) 13 2.7e-5 0.0194 0.0835 0.663
0.594-0.729
1.9
OR 95% CI: 0.288-12.5
Binary nominal
187.2 Malignant neoplasm of testis
Self-reported testicular cancer
MGI GWAS Hits UKB GWAS (PHESANT) 9 3.1e-5 0.0241 0.0838 0.658
0.594-0.719
2.64
OR 95% CI: 0.535-13
Binary nominal
204.4 Multiple myeloma
(hyperdiploidy);Multiple myeloma (IgH translocation);Multiple myeloma;Multiple myeloma and monoclonal gammopathy
UKB P&T GWAS Catalog (2019-05-03) 21 3.4e-5 0.0277 0.0818 0.576
0.536-0.616
2.2
OR 95% CI: 0.854-5.66
Binary nominal
153.2 Colon cancer
Cancer code, self-reported: colon cancer/sigmoid cancer (UKB GWAS (PHESANT))
MGI P&T UKB GWAS (PheCode) 12 4.4e-5 0.0031 0.0831 0.55
0.522-0.577
1.6
OR 95% CI: 0.733-3.51
Binary nominal
184.11 Malignant neoplasm of ovary
Serous invasive ovarian cancer
UKB Fixed threshold (5e-07) Phelan CM et al. 2017 31 4.5e-5 0.004 0.0825 0.547
0.518-0.575
1.76
OR 95% CI: 0.838-3.69
Binary nominal
184.11 Malignant neoplasm of ovary
Serous invasive ovarian cancer
UKB lassosum Phelan CM et al. 2017 110710 4.9e-5 0.0151 0.0825 0.556
0.529-0.583
1.76
OR 95% CI: 0.839-3.69
Binary nominal
184.11 Malignant neoplasm of ovary
Ovarian clear cell cancer
UKB lassosum Phelan CM et al. 2017 1098236 5e-5 0.0098 0.0824 0.546
0.52-0.574
1.76
OR 95% CI: 0.839-3.69
Binary nominal
10001 Any Cancer
MGI GWAS Hits UKB GWAS (PheCode) 14 5.1e-5 0.0027 0.182 0.515
0.503-0.526
1.48
OR 95% CI: 1.04-2.1
Binary nominal
153 Colorectal cancer
Cancer code, self-reported: large bowel cancer/colorectal cancer (UKB GWAS (PHESANT))
MGI PRS-CS UKB GWAS (PheCode) 1119238 5.5e-5 0.006 0.0829 0.548
0.523-0.572
1.71
OR 95% CI: 0.882-3.33
Binary nominal
187.2 Malignant neoplasm of testis
Self-reported testicular cancer
MGI Fixed threshold (5e-06) UKB GWAS (PHESANT) 27 6e-5 0.0182 0.0836 0.643
0.574-0.713
3.44
OR 95% CI: 0.735-16.1
Binary nominal
193 Thyroid cancer
Malignant neoplasm of thyroid gland
MGI Fixed threshold (5e-07) UKB GWAS (FINNGEN) 5 6.1e-5 0.0097 0.0825 0.549
0.518-0.58
1.39
OR 95% CI: 0.562-3.44
Binary nominal
10001 Any Cancer
MGI PRS-CS UKB GWAS (PheCode) 1118667 6.3e-5 0.0009 0.182 0.521
0.51-0.532
1.27
OR 95% CI: 0.887-1.81
Binary nominal
10001 Any Cancer
MGI Fixed threshold (5e-09) UKB GWAS (PheCode) 10 6.7e-5 0.0028 0.182 0.513
0.501-0.525
1.19
OR 95% CI: 0.825-1.72
Binary nominal
187.2 Malignant neoplasm of testis
Self-reported testicular cancer
MGI lassosum UKB GWAS (PHESANT) 771 6.7e-5 0.0505 0.084 0.656
0.593-0.717
2.72
OR 95% CI: 0.568-13.1
Binary nominal
187.2 Malignant neoplasm of testis
Diagnoses - main ICD10: C62 Malignant neoplasm of testis (UKB GWAS (ICD10))
MGI P&T UKB GWAS (FINNGEN) 31 6.9e-5 0.0376 0.0844 0.637
0.568-0.703
4.35
OR 95% CI: 1.08-17.5
Binary nominal
204.4 Multiple myeloma
(hyperdiploidy);Multiple myeloma (IgH translocation);Multiple myeloma;Multiple myeloma and monoclonal gammopathy
UKB Fixed threshold (5e-07) GWAS Catalog (2019-05-03) 28 8.8e-5 0.0218 0.0819 0.573
0.532-0.611
1.78
OR 95% CI: 0.639-4.98
Binary nominal
184.11 Malignant neoplasm of ovary
Serous invasive ovarian cancer
UKB PRS-CS Phelan CM et al. 2017 1115189 8.9e-5 0.0158 0.0825 0.552
0.526-0.58
1.55
OR 95% CI: 0.708-3.38
Binary nominal
157 Pancreatic cancer
UKB Fixed threshold (5e-05) GWAS Catalog (2019-05-03) 32 9.7e-5 0.006 0.0824 0.56
0.528-0.595
1.96
OR 95% CI: 0.832-4.63
Binary nominal
187.2 Malignant neoplasm of testis
Diagnoses - main ICD10: C62 Malignant neoplasm of testis (UKB GWAS (ICD10))
MGI lassosum UKB GWAS (FINNGEN) 250 1.1e-4 0.0531 0.0839 0.636
0.565-0.698
6.35
OR 95% CI: 1.81-22.3
Binary nominal
189.2 Cancer of bladder
Bladder cancer;Urinary bladder cancer (GWAS Catalog (2019-05-03))
MGI Fixed threshold (5e-06) UKB GWAS (PheCode) 21 1.1e-4 0.0008 0.0921 0.537
0.515-0.558
1.08
OR 95% CI: 0.526-2.23
Binary nominal
187.2 Malignant neoplasm of testis
Diagnoses - main ICD10: C62 Malignant neoplasm of testis (UKB GWAS (ICD10))
MGI Fixed threshold (5e-06) UKB GWAS (FINNGEN) 22 1.2e-4 0.0306 0.0845 0.636
0.571-0.7
2.24
OR 95% CI: 0.344-14.6
Binary nominal
187.2 Malignant neoplasm of testis
Self-reported testicular cancer
MGI Fixed threshold (5e-09) UKB GWAS (PHESANT) 7 1.2e-4 0.0262 0.0841 0.65
0.587-0.713
4.93
OR 95% CI: 1.29-18.8
Binary nominal
187.2 Malignant neoplasm of testis
Testicular germ cell tumor;Testicular germ cell cancer
MGI P&T GWAS Catalog (2019-05-03) 22 1.2e-4 0.0136 0.084 0.625
0.557-0.693
6.05
OR 95% CI: 1.73-21.2
Binary nominal
204.4 Multiple myeloma
(hyperdiploidy);Multiple myeloma (IgH translocation);Multiple myeloma;Multiple myeloma and monoclonal gammopathy
UKB Fixed threshold (5e-09) GWAS Catalog (2019-05-03) 15 1.2e-4 0.0222 0.0819 0.571
0.532-0.61
2.61
OR 95% CI: 1.08-6.33
Binary nominal
174.1 Breast cancer [female]
ICD-10 D05 Carcinoma in situ of breast
MGI P&T UKB GWAS (ICD10) 25 1.4e-4 0.0021 0.139 0.52
0.504-0.538
1.39
OR 95% CI: 0.817-2.36
Binary nominal
174.1 Breast cancer [female]
ICD-10 D05 Carcinoma in situ of breast
MGI Fixed threshold (5e-06) UKB GWAS (ICD10) 19 1.6e-4 0.0013 0.139 0.519
0.502-0.536
1.46
OR 95% CI: 0.87-2.46
Binary nominal
10001 Any Cancer
MGI Fixed threshold (5e-05) UKB GWAS (PheCode) 171 1.8e-4 0.0013 0.182 0.524
0.512-0.535
1.15
OR 95% CI: 0.802-1.65
Binary nominal
172 Skin cancer
Self-reported skin cancer
MGI Fixed threshold (5e-05) UKB GWAS (PHESANT) 132 1.8e-4 0.0019 0.148 0.515
0.504-0.526
1.31
OR 95% CI: 0.925-1.86
Binary nominal
187.2 Malignant neoplasm of testis
Diagnoses - main ICD10: C62 Malignant neoplasm of testis (UKB GWAS (ICD10))
MGI Fixed threshold (5e-09) UKB GWAS (FINNGEN) 5 1.8e-4 0.0316 0.0839 0.651
0.585-0.715
4.29
OR 95% CI: 1.1-16.8
Binary nominal
187.2 Malignant neoplasm of testis
Self-reported testicular cancer
MGI P&T UKB GWAS (PHESANT) 5 1.9e-4 0.0309 0.0841 0.649
0.586-0.714
3.49
OR 95% CI: 0.816-14.9
Binary nominal
187.2 Malignant neoplasm of testis
Diagnoses - main ICD10: C62 Malignant neoplasm of testis (UKB GWAS (ICD10))
MGI GWAS Hits UKB GWAS (FINNGEN) 6 2e-4 0.0288 0.0841 0.648
0.581-0.712
3.85
OR 95% CI: 0.942-15.7
Binary nominal
184.11 Malignant neoplasm of ovary
Serous invasive ovarian cancer
UKB P&T Phelan CM et al. 2017 12 2.3e-4 0.0063 0.0826 0.547
0.52-0.574
0.511
OR 95% CI: 0.142-1.84
Binary nominal
184.11 Malignant neoplasm of ovary
Invasive epithelial ovarian cancer
UKB lassosum Phelan CM et al. 2017 41269 2.8e-4 0.0119 0.0825 0.552
0.523-0.58
1.97
OR 95% CI: 0.97-3.99
Binary nominal
193 Thyroid cancer
Cancer code, self-reported: thyroid cancer (UKB GWAS (PHESANT))
MGI Fixed threshold (5e-06) UKB GWAS (PheCode) 11 3.3e-4 0.0073 0.0825 0.54
0.509-0.568
1.89
OR 95% CI: 0.854-4.19
Binary nominal
165.1 Cancer of bronchus; lung
Lung cancer in ever smokers;Squamous cell lung carcinoma;Lung adenocarcinoma;Lung cancer;Lung cancer in never smokers;Familial squamous cell lung carcinoma;Familial lung adenocarcinoma;Familial lung cancer;Small cell lung carcinoma
UKB Fixed threshold (5e-06) GWAS Catalog (2019-05-03) 210 3.8e-4 0.0015 0.0825 0.52
0.504-0.537
1.3
OR 95% CI: 0.75-2.27
Binary nominal
174.1 Breast cancer [female]
ER negative
MGI Fixed threshold (5e-05) Michailidou K et al. 2018 158 4e-4 0.0022 0.14 0.53
0.512-0.547
1.53
OR 95% CI: 0.917-2.54
Binary nominal
157 Pancreatic cancer
UKB Fixed threshold (5e-06) GWAS Catalog (2019-05-03) 30 4.3e-4 0.0052 0.0825 0.554
0.522-0.588
2.56
OR 95% CI: 1.19-5.53
Binary nominal
184.11 Malignant neoplasm of ovary
Low-grade serous and serous borderline ovarian cancer
UKB GWAS Hits Phelan CM et al. 2017 10 4.4e-4 0.0036 0.0825 0.556
0.53-0.584
1.76
OR 95% CI: 0.839-3.69
Binary nominal
189.2 Cancer of bladder
Bladder cancer;Urinary bladder cancer (GWAS Catalog (2019-05-03))
MGI lassosum UKB GWAS (PheCode) 24359 5.9e-4 0.0037 0.0921 0.538
0.517-0.557
0.983
OR 95% CI: 0.459-2.11
Binary nominal
165.1 Cancer of bronchus; lung
Lung cancer in ever smokers;Squamous cell lung carcinoma;Lung adenocarcinoma;Lung cancer;Lung cancer in never smokers;Familial squamous cell lung carcinoma;Familial lung adenocarcinoma;Familial lung cancer;Small cell lung carcinoma
MGI Fixed threshold (5e-06) GWAS Catalog (2019-05-03) 210 6.8e-4 0.0001 0.0826 0.545
0.515-0.574
1.05
OR 95% CI: 0.391-2.8
Binary nominal
187.2 Malignant neoplasm of testis
Testicular germ cell tumor;Testicular germ cell cancer
MGI Fixed threshold (5e-09) GWAS Catalog (2019-05-03) 31 7.2e-4 0.0108 0.0844 0.606
0.533-0.679
4.83
OR 95% CI: 1.23-18.9
Binary nominal
189.11 Malignant neoplasm of kidney, except pelvis
Renal cell carcinoma;Wilms tumor
UKB GWAS Hits GWAS Catalog (2019-05-03) 12 7.7e-4 0.0007 0.0825 0.517
0.492-0.54
2.17
OR 95% CI: 1.13-4.14
Binary nominal
189.11 Malignant neoplasm of kidney, except pelvis
Renal cell carcinoma;Wilms tumor
UKB P&T GWAS Catalog (2019-05-03) 12 7.7e-4 0.0007 0.0825 0.517
0.492-0.54
2.17
OR 95% CI: 1.13-4.14
Binary nominal
153.2 Colon cancer
ICD-10 C18 Malignant neoplasm of colon
MGI PRS-CS UKB GWAS (ICD10) 1111490 8.9e-4 0.003 0.0832 0.547
0.518-0.576
1.65
OR 95% CI: 0.753-3.61
Binary nominal
184.11 Malignant neoplasm of ovary
High-grade serous ovarian cancer
UKB Fixed threshold (5e-05) Phelan CM et al. 2017 116 9.4e-4 0.0008 0.0826 0.543
0.516-0.57
0.923
OR 95% CI: 0.347-2.45
Binary nominal
153.2 Colon cancer
ICD-10 C18 Malignant neoplasm of colon
MGI lassosum UKB GWAS (ICD10) 5740814 0.0011 0.0025 0.0831 0.545
0.518-0.574
1.4
OR 95% CI: 0.607-3.22
Binary nominal
172.3 Carcinoma in situ of skin
Diagnoses - main ICD10: D04 Carcinoma in situ of skin (UKB GWAS (ICD10))
MGI Fixed threshold (5e-05) UKB GWAS (PheCode) 99 0.0011 0.0062 0.0938 0.535
0.511-0.559
1.9
OR 95% CI: 1.01-3.58
Binary nominal
184.11 Malignant neoplasm of ovary
Epithelial ovarian cancer
UKB Fixed threshold (5e-09) Phelan CM et al. 2017 5 0.0012 0.0022 0.0826 0.544
0.516-0.572
1.18
OR 95% CI: 0.547-2.54
Binary nominal
172.21 Basal cell carcinoma
Self-reported rodent ulcer
MGI PRS-CS UKB GWAS (PHESANT) 1073162 0.0016 0.0003 0.109 0.525
0.509-0.54
1.65
OR 95% CI: 1.04-2.61
Binary nominal
184.11 Malignant neoplasm of ovary
Serous invasive ovarian cancer
UKB Fixed threshold (5e-05) Phelan CM et al. 2017 207 0.0016 0.0031 0.0826 0.539
0.512-0.565
1.97
OR 95% CI: 0.971-3.99
Binary nominal
189.11 Malignant neoplasm of kidney, except pelvis
Renal cell carcinoma;Wilms tumor
UKB Fixed threshold (5e-09) GWAS Catalog (2019-05-03) 8 0.0017 0 0.0825 0.513
0.49-0.537
2.36
OR 95% CI: 1.26-4.41
Binary nominal
165.1 Cancer of bronchus; lung
Lung cancer in ever smokers;Squamous cell lung carcinoma;Lung adenocarcinoma;Lung cancer;Lung cancer in never smokers;Familial squamous cell lung carcinoma;Familial lung adenocarcinoma;Familial lung cancer;Small cell lung carcinoma
UKB Fixed threshold (5e-05) GWAS Catalog (2019-05-03) 289 0.0019 0.0018 0.0826 0.516
0.499-0.534
1.58
OR 95% CI: 0.949-2.63
Binary nominal
201 Hodgkin's disease
Hodgkin's lymphoma;Nodular sclerosis Hodgkin lymphoma
MGI Fixed threshold (5e-05) GWAS Catalog (2019-05-03) 20 0.0019 0.0076 0.0821 0.62
0.559-0.688
2.64
OR 95% CI: 0.572-12.2
Binary nominal
201 Hodgkin's disease
Hodgkin's lymphoma;Nodular sclerosis Hodgkin lymphoma
MGI Fixed threshold (5e-06) GWAS Catalog (2019-05-03) 20 0.0019 0.0076 0.0821 0.62
0.559-0.688
2.64
OR 95% CI: 0.572-12.2
Binary nominal
201 Hodgkin's disease
Hodgkin's lymphoma;Nodular sclerosis Hodgkin lymphoma
MGI P&T GWAS Catalog (2019-05-03) 20 0.0019 0.0076 0.0821 0.62
0.559-0.688
2.64
OR 95% CI: 0.572-12.2
Binary nominal
204.4 Multiple myeloma
(hyperdiploidy);Multiple myeloma (IgH translocation);Multiple myeloma;Multiple myeloma and monoclonal gammopathy
UKB Fixed threshold (5e-06) GWAS Catalog (2019-05-03) 45 0.002 0.0111 0.0821 0.554
0.515-0.595
3
OR 95% CI: 1.3-6.93
Binary nominal
201 Hodgkin's disease
Self-reported hodgkins lymphoma / hodgkins disease
MGI Fixed threshold (5e-06) UKB GWAS (PHESANT) 15 0.0021 0.0134 0.0823 0.616
0.555-0.68
1.7
OR 95% CI: 0.27-10.7
Binary nominal
201 Hodgkin's disease
Hodgkin's lymphoma;Nodular sclerosis Hodgkin lymphoma
MGI Fixed threshold (5e-09) GWAS Catalog (2019-05-03) 10 0.0021 0.0001 0.0819 0.611
0.541-0.682
2.86
OR 95% CI: 0.629-13
Binary nominal
187.2 Malignant neoplasm of testis
Diagnoses - main ICD10: C62 Malignant neoplasm of testis (UKB GWAS (ICD10))
MGI Fixed threshold (5e-05) UKB GWAS (FINNGEN) 113 0.0024 0.0162 0.0846 0.606
0.526-0.682
0
OR 95% CI: 0-0
Binary nominal
187.2 Malignant neoplasm of testis
Diagnoses - main ICD10: C62 Malignant neoplasm of testis (UKB GWAS (ICD10))
MGI Fixed threshold (5e-07) UKB GWAS (FINNGEN) 8 0.0026 0.0229 0.0849 0.618
0.553-0.684
2.66
OR 95% CI: 0.549-12.9
Binary nominal
204.1 Lymphoid leukemia
Lymphoid leukaemia
MGI P&T UKB GWAS (FINNGEN) 6 0.0026 0.0155 0.0819 0.578
0.517-0.642
3.69
OR 95% CI: 1.01-13.4
Binary nominal
149.4 Cancer of larynx
ICD-10 C32 Malignant neoplasm of larynx
MGI lassosum UKB GWAS (ICD10) 25920 0.0027 0.0068 0.0822 0.57
0.522-0.618
2.14
OR 95% CI: 0.649-7.06
Binary nominal
184.11 Malignant neoplasm of ovary
Epithelial ovarian cancer
UKB GWAS Hits Phelan CM et al. 2017 6 0.0027 0.0035 0.0826 0.544
0.517-0.573
0.922
OR 95% CI: 0.347-2.45
Binary nominal
187.2 Malignant neoplasm of testis
Testicular germ cell tumor;Testicular germ cell cancer
MGI GWAS Hits GWAS Catalog (2019-05-03) 40 0.003 0.0091 0.085 0.598
0.526-0.672
0
OR 95% CI: 0-0
Binary nominal
187.2 Malignant neoplasm of testis
Self-reported testicular cancer
MGI Fixed threshold (5e-05) UKB GWAS (PHESANT) 135 0.0031 0.0024 0.0846 0.608
0.539-0.676
3.42
OR 95% CI: 0.74-15.8
Binary nominal
201 Hodgkin's disease
Hodgkin's lymphoma;Nodular sclerosis Hodgkin lymphoma
MGI Fixed threshold (5e-07) GWAS Catalog (2019-05-03) 19 0.0031 0.0038 0.0821 0.618
0.552-0.687
2.69
OR 95% CI: 0.587-12.3
Binary nominal
189.11 Malignant neoplasm of kidney, except pelvis
Renal cell carcinoma;Wilms tumor
UKB Fixed threshold (5e-05) GWAS Catalog (2019-05-03) 13 0.0032 0.0005 0.0825 0.511
0.486-0.535
2.17
OR 95% CI: 1.13-4.14
Binary nominal
189.11 Malignant neoplasm of kidney, except pelvis
Renal cell carcinoma;Wilms tumor
UKB Fixed threshold (5e-06) GWAS Catalog (2019-05-03) 13 0.0032 0.0005 0.0825 0.511
0.486-0.535
2.17
OR 95% CI: 1.13-4.14
Binary nominal
189.11 Malignant neoplasm of kidney, except pelvis
Renal cell carcinoma;Wilms tumor
UKB Fixed threshold (5e-07) GWAS Catalog (2019-05-03) 13 0.0032 0.0005 0.0825 0.511
0.486-0.535
2.17
OR 95% CI: 1.13-4.14
Binary nominal
187.2 Malignant neoplasm of testis
Testicular germ cell tumor;Testicular germ cell cancer
MGI Fixed threshold (5e-05) GWAS Catalog (2019-05-03) 46 0.0033 0.0115 0.0851 0.599
0.529-0.67
0
OR 95% CI: 0-0
Binary nominal
153 Colorectal cancer
Cancer code, self-reported: large bowel cancer/colorectal cancer (UKB GWAS (PHESANT))
MGI Fixed threshold (5e-05) UKB GWAS (PheCode) 141 0.0034 0.0034 0.083 0.53
0.506-0.554
1.04
OR 95% CI: 0.459-2.36
Binary nominal
150 Cancer of esophagus
ICD-10 C15 Malignant neoplasm of oesophagus
MGI PRS-CS UKB GWAS (ICD10) 1081646 0.0036 0.0034 0.0825 0.564
0.525-0.604
2.84
OR 95% CI: 1.07-7.54
Binary nominal
184.11 Malignant neoplasm of ovary
Ovarian clear cell cancer
UKB PRS-CS Phelan CM et al. 2017 1115187 0.0039 0.0035 0.0826 0.534
0.508-0.562
1.55
OR 95% CI: 0.71-3.38
Binary nominal
187.2 Malignant neoplasm of testis
Testicular germ cell tumor;Testicular germ cell cancer
MGI Fixed threshold (5e-06) GWAS Catalog (2019-05-03) 44 0.0041 0.0105 0.085 0.594
0.526-0.666
0
OR 95% CI: 0-0
Binary nominal
193 Thyroid cancer
Self-reported thyroid cancer
MGI Fixed threshold (5e-06) UKB GWAS (PHESANT) 8 0.0041 0.0074 0.0826 0.529
0.496-0.559
2.44
OR 95% CI: 1.18-5.02
Binary nominal
193 Thyroid cancer
Self-reported thyroid cancer
MGI P&T UKB GWAS (PHESANT) 8 0.0041 0.0074 0.0826 0.529
0.496-0.559
2.44
OR 95% CI: 1.18-5.02
Binary nominal
184.11 Malignant neoplasm of ovary
Epithelial ovarian cancer;High-grade serous ovarian cancer;Serous invasive ovarian cancer;Invasive epithelial ovarian cancer;Mucinous ovarian carcinoma;Low-grade serous and serous borderline ovarian cancer;Serous borderline ovarian cancer;Ovarian cancer in BRCA1 mutation carriers;Ovarian cancer;Ovarian clear cell cancer
UKB Fixed threshold (5e-09) GWAS Catalog (2019-05-03) 14 0.0042 0.0004 0.0826 0.535
0.508-0.562
1.13
OR 95% CI: 0.463-2.77
Binary nominal
165.1 Cancer of bronchus; lung
Lung cancer in ever smokers;Squamous cell lung carcinoma;Lung adenocarcinoma;Lung cancer;Lung cancer in never smokers;Familial squamous cell lung carcinoma;Familial lung adenocarcinoma;Familial lung cancer;Small cell lung carcinoma
MGI Fixed threshold (5e-05) GWAS Catalog (2019-05-03) 289 0.0043 0 0.0826 0.534
0.504-0.561
1.28
OR 95% CI: 0.518-3.14
Binary nominal
184 Cancer of other female genital organs
malignant neoplasm of female genital organs
MGI P&T UKB GWAS (FINNGEN) 8 0.0043 0.0013 0.0836 0.51
0.483-0.537
1.63
OR 95% CI: 0.743-3.57
Binary nominal
153.2 Colon cancer
Cancer code, self-reported: colon cancer/sigmoid cancer (UKB GWAS (PHESANT))
MGI Fixed threshold (5e-05) UKB GWAS (PheCode) 127 0.0044 0 0.0832 0.536
0.509-0.565
0.729
OR 95% CI: 0.243-2.19
Binary nominal
150 Cancer of esophagus
ICD-10 C15 Malignant neoplasm of oesophagus
MGI Fixed threshold (5e-05) UKB GWAS (ICD10) 109 0.0047 0.0019 0.0825 0.555
0.514-0.596
2.3
OR 95% CI: 0.798-6.63
Binary nominal
184 Cancer of other female genital organs
malignant neoplasm of female genital organs
MGI Fixed threshold (5e-06) UKB GWAS (FINNGEN) 11 0.0049 0.0001 0.0836 0.517
0.488-0.544
2.09
OR 95% CI: 1.03-4.27
Binary nominal
150 Cancer of esophagus
Esophageal adenocarcinoma (GWAS Catalog (2019-05-03))
MGI PRS-CS UKB GWAS (PheCode) 1119238 0.005 0.0004 0.0825 0.564
0.522-0.605
1.28
OR 95% CI: 0.332-4.95
Binary nominal
184.11 Malignant neoplasm of ovary
Low-grade serous and serous borderline ovarian cancer
UKB Fixed threshold (5e-06) Phelan CM et al. 2017 28 0.0054 0.0026 0.0826 0.54
0.513-0.567
1.97
OR 95% CI: 0.971-4
Binary nominal
204.12 Lymphoid leukemia, chronic
Chronic lymphocytic leukemia (GWAS Catalog (2019-05-03))
MGI Fixed threshold (5e-07) UKB GWAS (PheCode) 6 0.0054 0.0174 0.0822 0.577
0.511-0.645
2
OR 95% CI: 0.308-13
Binary nominal
204.12 Lymphoid leukemia, chronic
Chronic lymphocytic leukemia (GWAS Catalog (2019-05-03))
MGI P&T UKB GWAS (PheCode) 6 0.0054 0.0174 0.0822 0.577
0.511-0.645
2
OR 95% CI: 0.308-13
Binary nominal
174.1 Breast cancer [female]
ICD-10 D05 Carcinoma in situ of breast
MGI Fixed threshold (5e-05) UKB GWAS (ICD10) 120 0.0055 0.0007 0.14 0.517
0.499-0.534
1.16
OR 95% CI: 0.667-2.02
Binary nominal
184.11 Malignant neoplasm of ovary
Low-grade serous and serous borderline ovarian cancer
UKB Fixed threshold (5e-07) Phelan CM et al. 2017 13 0.0056 0.0055 0.0826 0.542
0.516-0.569
2.82
OR 95% CI: 1.53-5.22
Binary nominal
187.2 Malignant neoplasm of testis
Testicular germ cell tumor;Testicular germ cell cancer
MGI Fixed threshold (5e-07) GWAS Catalog (2019-05-03) 42 0.0057 0.0096 0.0851 0.59
0.521-0.665
0
OR 95% CI: 0-0
Binary nominal
153 Colorectal cancer
Cancer code, self-reported: large bowel cancer/colorectal cancer (UKB GWAS (PHESANT))
MGI Fixed threshold (5e-07) UKB GWAS (PheCode) 10 0.0062 0.0041 0.083 0.53
0.504-0.554
1.53
OR 95% CI: 0.764-3.05
Binary nominal
153.2 Colon cancer
Malignant neoplasm of colon
MGI lassosum UKB GWAS (FINNGEN) 5715093 0.0064 0.0026 0.0832 0.536
0.51-0.567
0.757
OR 95% CI: 0.252-2.28
Binary nominal
165.1 Cancer of bronchus; lung
Lung cancer and mesothelioma
MGI PRS-CS UKB GWAS (FINNGEN) 1110438 0.0064 0 0.0826 0.539
0.508-0.568
2.18
OR 95% CI: 1.06-4.46
Binary nominal
165.1 Cancer of bronchus; lung
Lung cancer and mesothelioma
MGI PRS-CS UKB GWAS (FINNGEN) 1110438 0.0064 0 0.0826 0.539
0.508-0.568
2.18
OR 95% CI: 1.06-4.46
Binary nominal
172.21 Basal cell carcinoma
Self-reported rodent ulcer
MGI P&T UKB GWAS (PHESANT) 8 0.0064 0.0015 0.109 0.504
0.489-0.52
1.42
OR 95% CI: 0.882-2.3
Binary nominal
153.2 Colon cancer
Malignant neoplasm of colon
MGI PRS-CS UKB GWAS (FINNGEN) 1111399 0.0065 0.0037 0.0832 0.536
0.509-0.565
1.82
OR 95% CI: 0.867-3.84
Binary nominal
193 Thyroid cancer
Self-reported thyroid cancer
MGI Fixed threshold (5e-05) UKB GWAS (PHESANT) 69 0.0068 0.002 0.0827 0.534
0.505-0.565
1.13
OR 95% CI: 0.42-3.04
Binary nominal
165.1 Cancer of bronchus; lung
Lung cancer in ever smokers;Squamous cell lung carcinoma;Lung adenocarcinoma;Lung cancer;Lung cancer in never smokers;Familial squamous cell lung carcinoma;Familial lung adenocarcinoma;Familial lung cancer;Small cell lung carcinoma
MGI Fixed threshold (5e-07) GWAS Catalog (2019-05-03) 58 0.0074 0.0001 0.0826 0.525
0.497-0.553
1.75
OR 95% CI: 0.797-3.86
Binary nominal
189.2 Cancer of bladder
ICD-10 C67 Malignant neoplasm of bladder
MGI lassosum UKB GWAS (ICD10) 1130 0.0074 0.0028 0.0922 0.528
0.508-0.549
1.69
OR 95% CI: 0.934-3.06
Binary nominal
172.22 Squamous cell carcinoma
Self-reported squamous cell carcinoma
MGI lassosum UKB GWAS (PHESANT) 4279140 0.0076 0.0005 0.0996 0.523
0.503-0.543
1.56
OR 95% CI: 0.892-2.74
Binary nominal
193 Thyroid cancer
Cancer code, self-reported: thyroid cancer (UKB GWAS (PHESANT))
MGI Fixed threshold (5e-05) UKB GWAS (PheCode) 86 0.0076 0.0025 0.0827 0.529
0.498-0.558
1.92
OR 95% CI: 0.865-4.24
Binary nominal
184.11 Malignant neoplasm of ovary
Epithelial ovarian cancer
UKB Fixed threshold (5e-07) Phelan CM et al. 2017 7 0.0084 0.0048 0.0826 0.535
0.509-0.563
1.29
OR 95% CI: 0.562-2.94
Binary nominal
191.11 Cancer of brain
ICD-10 C71 Malignant neoplasm of brain
MGI lassosum UKB GWAS (ICD10) 522 0.0092 0.0016 0.0824 0.546
0.504-0.587
1.42
OR 95% CI: 0.453-4.47
Binary nominal
191.11 Cancer of brain
ICD-10 C71 Malignant neoplasm of brain
MGI Fixed threshold (5e-06) UKB GWAS (ICD10) 15 0.0097 0.0013 0.0824 0.541
0.5-0.582
3.56
OR 95% CI: 1.59-7.96
Binary nominal
184.11 Malignant neoplasm of ovary
Low-grade serous and serous borderline ovarian cancer
UKB P&T Phelan CM et al. 2017 15 0.0099 0.0066 0.0826 0.539
0.513-0.568
2.18
OR 95% CI: 1.11-4.3
Binary nominal
201 Hodgkin's disease
Hodgkin's lymphoma;Nodular sclerosis Hodgkin lymphoma
MGI GWAS Hits GWAS Catalog (2019-05-03) 16 0.0099 0.0019 0.0824 0.601
0.535-0.671
1.62
OR 95% CI: 0.258-10.1
Binary nominal
184.11 Malignant neoplasm of ovary
Epithelial ovarian cancer
UKB lassosum Phelan CM et al. 2017 1441 0.01 0.0039 0.0826 0.538
0.512-0.565
1.13
OR 95% CI: 0.463-2.77
Binary nominal
145 Cancer of mouth
MGI PRS-CS UKB GWAS (PheCode) 1119238 0.012 0.0002 0.0829 0.528
0.502-0.552
1.63
OR 95% CI: 0.812-3.26
Binary nominal
150 Cancer of esophagus
ICD-10 C15 Malignant neoplasm of oesophagus
MGI lassosum UKB GWAS (ICD10) 2001 0.012 0.0042 0.0826 0.551
0.51-0.588
1.81
OR 95% CI: 0.56-5.82
Binary nominal
153 Colorectal cancer
Cancer code, self-reported: large bowel cancer/colorectal cancer (UKB GWAS (PHESANT))
MGI lassosum UKB GWAS (PheCode) 370 0.012 0.0038 0.083 0.53
0.503-0.555
2.76
OR 95% CI: 1.59-4.81
Binary nominal
145 Cancer of mouth
Malignant neoplasm of lip, oral cavity and pharynx
MGI P&T UKB GWAS (FINNGEN) 45 0.014 0.0016 0.0829 0.519
0.498-0.542
1.26
OR 95% CI: 0.585-2.73
Binary nominal
165.1 Cancer of bronchus; lung
Lung cancer in ever smokers;Squamous cell lung carcinoma;Lung adenocarcinoma;Lung cancer;Lung cancer in never smokers;Familial squamous cell lung carcinoma;Familial lung adenocarcinoma;Familial lung cancer;Small cell lung carcinoma (GWAS Catalog (2019-05-03))
MGI PRS-CS UKB GWAS (PheCode) 1119238 0.014 0.0002 0.0827 0.533
0.505-0.562
1.27
OR 95% CI: 0.514-3.12
Binary nominal
184.11 Malignant neoplasm of ovary
Epithelial ovarian cancer;High-grade serous ovarian cancer;Serous invasive ovarian cancer;Invasive epithelial ovarian cancer;Mucinous ovarian carcinoma;Low-grade serous and serous borderline ovarian cancer;Serous borderline ovarian cancer;Ovarian cancer in BRCA1 mutation carriers;Ovarian cancer;Ovarian clear cell cancer
UKB Fixed threshold (5e-05) GWAS Catalog (2019-05-03) 25 0.014 0.0007 0.0827 0.532
0.504-0.561
1.34
OR 95% CI: 0.584-3.07
Binary nominal
184.11 Malignant neoplasm of ovary
Epithelial ovarian cancer;High-grade serous ovarian cancer;Serous invasive ovarian cancer;Invasive epithelial ovarian cancer;Mucinous ovarian carcinoma;Low-grade serous and serous borderline ovarian cancer;Serous borderline ovarian cancer;Ovarian cancer in BRCA1 mutation carriers;Ovarian cancer;Ovarian clear cell cancer
UKB Fixed threshold (5e-06) GWAS Catalog (2019-05-03) 25 0.014 0.0007 0.0827 0.532
0.504-0.561
1.34
OR 95% CI: 0.584-3.07
Binary nominal
165.1 Cancer of bronchus; lung
Malignant neoplasm of bronchus and lung
MGI PRS-CS UKB GWAS (FINNGEN) 1109069 0.015 0 0.0827 0.533
0.505-0.562
1.96
OR 95% CI: 0.926-4.14
Binary nominal
189.2 Cancer of bladder
Self-reported bladder cancer
MGI PRS-CS UKB GWAS (PHESANT) 1095241 0.015 0.0008 0.0922 0.531
0.509-0.551
0.671
OR 95% CI: 0.279-1.61
Binary nominal
191.1 Cancer of brain and nervous system
Glioma;Non-glioblastoma glioma;Glioma (high-grade) (GWAS Catalog (2019-05-03))
MGI Fixed threshold (5e-06) UKB GWAS (PheCode) 17 0.015 0.0002 0.0825 0.53
0.495-0.563
1.22
OR 95% CI: 0.393-3.78
Binary nominal
184.11 Malignant neoplasm of ovary
Invasive epithelial ovarian cancer
UKB Fixed threshold (5e-05) Phelan CM et al. 2017 219 0.016 0.0039 0.0826 0.532
0.506-0.559
2.39
OR 95% CI: 1.24-4.61
Binary nominal
184.11 Malignant neoplasm of ovary
Low-grade serous and serous borderline ovarian cancer
UKB lassosum Phelan CM et al. 2017 486841 0.016 0.0051 0.0826 0.516
0.489-0.544
2.4
OR 95% CI: 1.24-4.62
Binary nominal
191.11 Cancer of brain
Glioblastoma (GWAS Catalog (2019-05-03))
MGI Fixed threshold (5e-06) UKB GWAS (PheCode) 14 0.016 0.0034 0.0824 0.534
0.495-0.574
1.41
OR 95% CI: 0.45-4.44
Binary nominal
193 Thyroid cancer
Malignant neoplasm of thyroid gland
MGI Fixed threshold (5e-05) UKB GWAS (FINNGEN) 96 0.016 0.0042 0.0827 0.532
0.503-0.561
1.65
OR 95% CI: 0.708-3.83
Binary nominal
145 Cancer of mouth
Malignant neoplasm of lip, oral cavity and pharynx
MGI Fixed threshold (5e-06) UKB GWAS (FINNGEN) 21 0.017 0.0002 0.0829 0.506
0.482-0.531
1.79
OR 95% CI: 0.918-3.49
Binary nominal
184.11 Malignant neoplasm of ovary
Epithelial ovarian cancer;High-grade serous ovarian cancer;Serous invasive ovarian cancer;Invasive epithelial ovarian cancer;Mucinous ovarian carcinoma;Low-grade serous and serous borderline ovarian cancer;Serous borderline ovarian cancer;Ovarian cancer in BRCA1 mutation carriers;Ovarian cancer;Ovarian clear cell cancer
UKB GWAS Hits GWAS Catalog (2019-05-03) 21 0.017 0.001 0.0827 0.532
0.506-0.559
0.923
OR 95% CI: 0.347-2.45
Binary nominal
184.11 Malignant neoplasm of ovary
Epithelial ovarian cancer;High-grade serous ovarian cancer;Serous invasive ovarian cancer;Invasive epithelial ovarian cancer;Mucinous ovarian carcinoma;Low-grade serous and serous borderline ovarian cancer;Serous borderline ovarian cancer;Ovarian cancer in BRCA1 mutation carriers;Ovarian cancer;Ovarian clear cell cancer
UKB P&T GWAS Catalog (2019-05-03) 21 0.017 0.001 0.0827 0.532
0.506-0.559
0.923
OR 95% CI: 0.347-2.45
Binary nominal
184.11 Malignant neoplasm of ovary
Epithelial ovarian cancer;High-grade serous ovarian cancer;Serous invasive ovarian cancer;Invasive epithelial ovarian cancer;Mucinous ovarian carcinoma;Low-grade serous and serous borderline ovarian cancer;Serous borderline ovarian cancer;Ovarian cancer in BRCA1 mutation carriers;Ovarian cancer;Ovarian clear cell cancer
UKB Fixed threshold (5e-07) GWAS Catalog (2019-05-03) 23 0.018 0.0008 0.0827 0.531
0.502-0.559
1.55
OR 95% CI: 0.709-3.38
Binary nominal
189 Cancer of urinary organs (incl. kidney and bladder)
Malignant neoplasm of urinary organs
MGI Fixed threshold (5e-06) UKB GWAS (FINNGEN) 12 0.019 0.0001 0.0974 0.489
0.473-0.505
1.41
OR 95% CI: 0.845-2.37
Binary nominal
189.2 Cancer of bladder
Bladder cancer;Urinary bladder cancer (GWAS Catalog (2019-05-03))
MGI Fixed threshold (5e-05) UKB GWAS (PheCode) 130 0.019 0.0019 0.0922 0.519
0.499-0.541
1.59
OR 95% CI: 0.876-2.87
Binary nominal
165.1 Cancer of bronchus; lung
Lung cancer in ever smokers;Squamous cell lung carcinoma;Lung adenocarcinoma;Lung cancer;Lung cancer in never smokers;Familial squamous cell lung carcinoma;Familial lung adenocarcinoma;Familial lung cancer;Small cell lung carcinoma (GWAS Catalog (2019-05-03))
MGI Fixed threshold (5e-05) UKB GWAS (PheCode) 109 0.02 0 0.0827 0.533
0.505-0.563
2.21
OR 95% CI: 1.08-4.52
Binary nominal
189.2 Cancer of bladder
ICD-10 C67 Malignant neoplasm of bladder
MGI Fixed threshold (5e-07) UKB GWAS (ICD10) 7 0.02 0 0.0922 0.512
0.492-0.53
0.578
OR 95% CI: 0.221-1.51
Binary nominal
172.21 Basal cell carcinoma
Self-reported rodent ulcer
MGI Fixed threshold (5e-06) UKB GWAS (PHESANT) 12 0.022 0.0012 0.109 0.504
0.488-0.52
1.14
OR 95% CI: 0.67-1.95
Binary nominal
184.11 Malignant neoplasm of ovary
Endometrioid ovarian cancer
UKB PRS-CS Phelan CM et al. 2017 1115189 0.022 0.0004 0.0827 0.526
0.498-0.554
1.97
OR 95% CI: 0.973-4
Binary nominal
202.21 Nodular lymphoma
Follicular lymphoma
MGI lassosum UKB GWAS (FINNGEN) 2209179 0.022 0.0014 0.0825 0.538
0.504-0.573
1.48
OR 95% CI: 0.538-4.05
Binary nominal
204.12 Lymphoid leukemia, chronic
Chronic lymphocytic leukemia (GWAS Catalog (2019-05-03))
MGI lassosum UKB GWAS (PheCode) 76 0.022 0.0043 0.0823 0.573
0.503-0.644
4.84
OR 95% CI: 1.23-19
Binary nominal
187 Cancer of other male genital organs
malignant neoplasm of male genital organs
MGI P&T UKB GWAS (FINNGEN) 97 0.023 0.0032 0.083 0.558
0.506-0.606
1.04
OR 95% CI: 0.183-5.95
Binary nominal
165.1 Cancer of bronchus; lung
Lung cancer in ever smokers;Squamous cell lung carcinoma;Lung adenocarcinoma;Lung cancer;Lung cancer in never smokers;Familial squamous cell lung carcinoma;Familial lung adenocarcinoma;Familial lung cancer;Small cell lung carcinoma (GWAS Catalog (2019-05-03))
MGI P&T UKB GWAS (PheCode) 75 0.024 0.0003 0.0827 0.525
0.496-0.554
2.21
OR 95% CI: 1.08-4.51
Binary nominal
189.2 Cancer of bladder
Self-reported bladder cancer
MGI Fixed threshold (5e-06) UKB GWAS (PHESANT) 17 0.024 0 0.0922 0.505
0.484-0.525
1.41
OR 95% CI: 0.75-2.66
Binary nominal
149.4 Cancer of larynx
Diagnoses - main ICD10: C32 Malignant neoplasm of larynx (UKB GWAS (ICD10))
MGI P&T UKB GWAS (PheCode) 53 0.025 0.0018 0.0824 0.543
0.494-0.59
1.52
OR 95% CI: 0.384-5.98
Binary nominal
165.1 Cancer of bronchus; lung
Lung cancer in ever smokers;Squamous cell lung carcinoma;Lung adenocarcinoma;Lung cancer;Lung cancer in never smokers;Familial squamous cell lung carcinoma;Familial lung adenocarcinoma;Familial lung cancer;Small cell lung carcinoma
MGI P&T GWAS Catalog (2019-05-03) 14 0.025 0.0027 0.0827 0.529
0.503-0.558
1.75
OR 95% CI: 0.796-3.85
Binary nominal
150 Cancer of esophagus
Malignant neoplasm of oesophagus
MGI PRS-CS UKB GWAS (FINNGEN) 1070434 0.026 0.0039 0.0826 0.553
0.514-0.596
1.27
OR 95% CI: 0.329-4.9
Binary nominal
172.1 Melanomas of skin, dx or hx
ICD-10 D03 Melanoma in situ
MGI P&T UKB GWAS (ICD10) 147 0.027 0.0006 0.0969 0.516
0.5-0.533
1.07
OR 95% CI: 0.603-1.9
Binary nominal
189.2 Cancer of bladder
Bladder cancer;Urinary bladder cancer (GWAS Catalog (2019-05-03))
MGI PRS-CS UKB GWAS (PheCode) 1119238 0.027 0.0016 0.0922 0.525
0.503-0.547
0.675
OR 95% CI: 0.28-1.62
Binary nominal
190 Cancer of eye
Self-reported eye and/or adnexal cancer
MGI PRS-CS UKB GWAS (PHESANT) 834009 0.027 0.0035 0.0831 0.586
0.508-0.658
4.74
OR 95% CI: 1.2-18.7
Binary nominal
193 Thyroid cancer
ICD-10 C73 Malignant neoplasm of thyroid gland
MGI P&T UKB GWAS (ICD10) 8 0.027 0.01 0.0827 0.52
0.488-0.55
2.15
OR 95% CI: 1.01-4.59
Binary nominal
204.1 Lymphoid leukemia
MGI Fixed threshold (5e-07) UKB GWAS (PheCode) 5 0.028 0.0152 0.0823 0.557
0.506-0.614
0
OR 95% CI: 0-0
Binary nominal
204.4 Multiple myeloma
and malignant plasma cell neoplasms
MGI Fixed threshold (5e-06) UKB GWAS (FINNGEN) 11 0.028 0.0007 0.0822 0.559
0.498-0.617
2.61
OR 95% CI: 0.598-11.4
Binary nominal
184.11 Malignant neoplasm of ovary
Serous invasive ovarian cancer
MGI Fixed threshold (5e-09) Phelan CM et al. 2017 19 0.029 0.0005 0.0827 0.552
0.506-0.595
1.36
OR 95% CI: 0.349-5.29
Binary nominal
182 Malignant neoplasm of uterus
Endometrial cancer;Endometrial cancer (endometrioid histology);Endometrial endometrioid carcinoma;Endometrial cancer (Non-endometrioid histology)
MGI Fixed threshold (5e-09) GWAS Catalog (2019-05-03) 11 0.03 0.0025 0.0831 0.532
0.501-0.565
1.33
OR 95% CI: 0.49-3.63
Binary nominal
184.11 Malignant neoplasm of ovary
Invasive epithelial ovarian cancer
MGI Fixed threshold (5e-06) Phelan CM et al. 2017 54 0.03 0.0004 0.0827 0.554
0.509-0.595
0.806
OR 95% CI: 0.146-4.44
Binary nominal
184.11 Malignant neoplasm of ovary
Low-grade serous ovarian cancer
UKB lassosum Phelan CM et al. 2017 1635861 0.03 0.004 0.0826 0.498
0.471-0.527
2.83
OR 95% CI: 1.53-5.23
Binary nominal
191.11 Cancer of brain
Glioblastoma
MGI Fixed threshold (5e-07) GWAS Catalog (2019-05-03) 12 0.03 0.0034 0.0825 0.54
0.503-0.579
1.02
OR 95% CI: 0.271-3.86
Binary nominal
191.11 Cancer of brain
Glioblastoma
MGI GWAS Hits GWAS Catalog (2019-05-03) 12 0.03 0.0034 0.0825 0.54
0.503-0.579
1.02
OR 95% CI: 0.271-3.86
Binary nominal
184.11 Malignant neoplasm of ovary
Serous invasive ovarian cancer
MGI GWAS Hits Phelan CM et al. 2017 21 0.031 0.0002 0.0827 0.554
0.509-0.597
0.784
OR 95% CI: 0.142-4.32
Binary nominal
184.11 Malignant neoplasm of ovary
Low-grade serous and serous borderline ovarian cancer
UKB PRS-CS Phelan CM et al. 2017 1115189 0.032 0.0014 0.0827 0.522
0.491-0.548
3.92
OR 95% CI: 2.27-6.79
Binary nominal
189.2 Cancer of bladder
Bladder cancer;Urinary bladder cancer (GWAS Catalog (2019-05-03))
MGI P&T UKB GWAS (PheCode) 106 0.032 0.0025 0.0922 0.519
0.498-0.541
0.788
OR 95% CI: 0.35-1.78
Binary nominal
201 Hodgkin's disease
Self-reported hodgkins lymphoma / hodgkins disease
MGI PRS-CS UKB GWAS (PHESANT) 1047511 0.032 0.0125 0.0826 0.574
0.501-0.642
1.67
OR 95% CI: 0.264-10.5
Binary nominal
149.4 Cancer of larynx
Malignant neoplasm of larynx
MGI lassosum UKB GWAS (FINNGEN) 87893 0.033 0.002 0.0824 0.55
0.504-0.593
1.51
OR 95% CI: 0.382-5.94
Binary nominal
153 Colorectal cancer
Cancer code, self-reported: large bowel cancer/colorectal cancer (UKB GWAS (PHESANT))
MGI Fixed threshold (5e-09) GWAS Catalog (2019-05-03) 12 0.033 0.0033 0.083 0.521
0.496-0.544
1.39
OR 95% CI: 0.67-2.87
Binary nominal
165 Cancer within the respiratory system
MGI lassosum UKB GWAS (PheCode) 879334 0.033 0.0019 0.0826 0.53
0.502-0.557
2.22
OR 95% CI: 1.12-4.37
Binary nominal
165.1 Cancer of bronchus; lung
Lung cancer in ever smokers;Squamous cell lung carcinoma;Lung adenocarcinoma;Lung cancer;Lung cancer in never smokers;Familial squamous cell lung carcinoma;Familial lung adenocarcinoma;Familial lung cancer;Small cell lung carcinoma (GWAS Catalog (2019-05-03))
MGI lassosum UKB GWAS (PheCode) 46920 0.033 0.0011 0.0827 0.528
0.503-0.556
1.03
OR 95% CI: 0.387-2.77
Binary nominal
184.11 Malignant neoplasm of ovary
Serous invasive ovarian cancer
MGI Fixed threshold (5e-07) Phelan CM et al. 2017 31 0.033 0.0005 0.0827 0.548
0.506-0.592
0.801
OR 95% CI: 0.145-4.43
Binary nominal
187 Cancer of other male genital organs
malignant neoplasm of male genital organs
MGI Fixed threshold (5e-07) UKB GWAS (FINNGEN) 64 0.033 0.0011 0.083 0.555
0.503-0.604
1.03
OR 95% CI: 0.181-5.88
Binary nominal
189.2 Cancer of bladder
Malignant neoplasm of bladder
MGI PRS-CS UKB GWAS (FINNGEN) 1097063 0.033 0.0001 0.0922 0.521
0.499-0.541
1.53
OR 95% CI: 0.832-2.83
Binary nominal
191.11 Cancer of brain
Glioblastoma
MGI Fixed threshold (5e-09) GWAS Catalog (2019-05-03) 11 0.035 0.0034 0.0825 0.538
0.501-0.577
0.602
OR 95% CI: 0.113-3.22
Binary nominal
191.11 Cancer of brain
Glioblastoma
MGI P&T GWAS Catalog (2019-05-03) 11 0.035 0.0034 0.0825 0.538
0.501-0.577
0.602
OR 95% CI: 0.113-3.22
Binary nominal
193 Thyroid cancer
Cancer code, self-reported: thyroid cancer (UKB GWAS (PHESANT))
MGI PRS-CS UKB GWAS (PheCode) 1119238 0.035 0.0002 0.0827 0.535
0.504-0.567
1.39
OR 95% CI: 0.562-3.45
Binary nominal
184.11 Malignant neoplasm of ovary
Serous invasive ovarian cancer
MGI PRS-CS Phelan CM et al. 2017 1114056 0.036 0.0019 0.0827 0.552
0.513-0.598
0
OR 95% CI: 0-0
Binary nominal
202.21 Nodular lymphoma
Follicular lymphoma
MGI Fixed threshold (5e-06) UKB GWAS (FINNGEN) 26 0.036 0.0002 0.0825 0.506
0.474-0.54
1.82
OR 95% CI: 0.72-4.61
Binary nominal
165.1 Cancer of bronchus; lung
Lung cancer in ever smokers;Squamous cell lung carcinoma;Lung adenocarcinoma;Lung cancer;Lung cancer in never smokers;Familial squamous cell lung carcinoma;Familial lung adenocarcinoma;Familial lung cancer;Small cell lung carcinoma
MGI GWAS Hits GWAS Catalog (2019-05-03) 21 0.037 0.0008 0.0827 0.52
0.492-0.547
2.19
OR 95% CI: 1.07-4.49
Binary nominal
172 Skin cancer
Self-reported skin cancer
MGI PRS-CS UKB GWAS (PHESANT) 1103220 0.037 0.001 0.148 0.51
0.499-0.521
1.7
OR 95% CI: 1.22-2.38
Binary nominal
153 Colorectal cancer
Cancer code, self-reported: large bowel cancer/colorectal cancer (UKB GWAS (PHESANT))
MGI P&T UKB GWAS (PheCode) 41 0.039 0.0063 0.083 0.517
0.493-0.541
1.88
OR 95% CI: 0.99-3.55
Binary nominal
145.2 Cancer of tongue
Malignant neoplasm of other and unspecified parts of tongue
MGI PRS-CS UKB GWAS (FINNGEN) 931954 0.04 0.0032 0.0827 0.538
0.501-0.575
1.69
OR 95% CI: 0.61-4.71
Binary nominal
153.3 Malignant neoplasm of rectum, rectosigmoid junction, and anus
ICD-10 C19 Malignant neoplasm of rectosigmoid junction
MGI PRS-CS UKB GWAS (ICD10) 1078799 0.04 0.0002 0.0829 0.533
0.5-0.567
1.34
OR 95% CI: 0.491-3.65
Binary nominal
180.3 Cervical intraepithelial neoplasia [CIN] [Cervical dysplasia]
Self-reported cin/pre-cancer cells cervix
MGI Fixed threshold (5e-07) UKB GWAS (PHESANT) 5 0.04 0.0006 0.0885 0.514
0.486-0.543
0.777
OR 95% CI: 0.257-2.35
Binary nominal
201 Hodgkin's disease
Diagnoses - main ICD10: C81 Hodgkin's disease (UKB GWAS (ICD10))
MGI lassosum UKB GWAS (PheCode) 1119335 0.04 0.0116 0.0828 0.569
0.501-0.634
1.64
OR 95% CI: 0.261-10.3
Binary nominal
202.21 Nodular lymphoma
Follicular lymphoma
MGI PRS-CS UKB GWAS (FINNGEN) 1048780 0.041 0 0.0825 0.532
0.497-0.568
2.49
OR 95% CI: 1.1-5.65
Binary nominal
153 Colorectal cancer
Cancer code, self-reported: large bowel cancer/colorectal cancer (UKB GWAS (PHESANT))
MGI Fixed threshold (5e-06) UKB GWAS (PheCode) 30 0.043 0.0056 0.083 0.518
0.493-0.543
1.55
OR 95% CI: 0.778-3.11
Binary nominal
191.11 Cancer of brain
Glioblastoma (GWAS Catalog (2019-05-03))
MGI P&T UKB GWAS (PheCode) 11 0.043 0.0057 0.0825 0.53
0.492-0.57
2.28
OR 95% CI: 0.88-5.88
Binary nominal
204.4 Multiple myeloma
ICD-10 C90 Multiple myeloma and malignant plasma cell neoplasms
MGI P&T UKB GWAS (ICD10) 27 0.044 0.0013 0.0823 0.547
0.479-0.613
2.6
OR 95% CI: 0.593-11.4
Binary nominal
187 Cancer of other male genital organs
malignant neoplasm of male genital organs
MGI Fixed threshold (5e-06) UKB GWAS (FINNGEN) 101 0.046 0.003 0.0831 0.551
0.5-0.599
1.04
OR 95% CI: 0.181-5.92
Binary nominal
187 Cancer of other male genital organs
malignant neoplasm of male genital organs
MGI GWAS Hits UKB GWAS (FINNGEN) 45 0.047 0.0003 0.0831 0.551
0.5-0.6
1.01
OR 95% CI: 0.177-5.76
Binary nominal
153.3 Malignant neoplasm of rectum, rectosigmoid junction, and anus
Malignant neoplasm of rectum
MGI PRS-CS UKB GWAS (FINNGEN) 1104018 0.048 0.0005 0.0829 0.531
0.495-0.563
1.02
OR 95% CI: 0.334-3.14
Binary nominal
172.3 Carcinoma in situ of skin
Diagnoses - main ICD10: D04 Carcinoma in situ of skin (UKB GWAS (ICD10))
MGI PRS-CS UKB GWAS (PheCode) 1119238 0.048 0.0026 0.0939 0.524
0.499-0.549
1.48
OR 95% CI: 0.703-3.1
Binary nominal
165.1 Cancer of bronchus; lung
Lung cancer in ever smokers;Squamous cell lung carcinoma;Lung adenocarcinoma;Lung cancer;Lung cancer in never smokers;Familial squamous cell lung carcinoma;Familial lung adenocarcinoma;Familial lung cancer;Small cell lung carcinoma
MGI Fixed threshold (5e-09) GWAS Catalog (2019-05-03) 18 0.049 0.0022 0.0827 0.526
0.498-0.554
0.584
OR 95% CI: 0.161-2.12
Binary nominal
157 Pancreatic cancer
MGI GWAS Hits GWAS Catalog (2019-05-03) 17 0.051 0.0107 0.0827 0.534
0.492-0.577
1.99
OR 95% CI: 0.704-5.62
Binary weak
157 Pancreatic cancer
MGI P&T GWAS Catalog (2019-05-03) 18 0.051 0.0134 0.0827 0.537
0.493-0.579
1.54
OR 95% CI: 0.487-4.9
Binary weak
170 Cancer of bone and connective tissue
MGI PRS-CS UKB GWAS (PheCode) 1119238 0.053 0.0003 0.083 0.522
0.502-0.543
0.824
OR 95% CI: 0.367-1.85
Binary weak
184.11 Malignant neoplasm of ovary
Invasive epithelial ovarian cancer
MGI Fixed threshold (5e-09) Phelan CM et al. 2017 13 0.053 0.0006 0.0828 0.545
0.5-0.592
1.31
OR 95% CI: 0.337-5.12
Binary weak
155 Cancer of liver and intrahepatic bile duct
MGI Fixed threshold (5e-05) UKB GWAS (PheCode) 78 0.054 0.0008 0.0825 0.533
0.492-0.573
0.69
OR 95% CI: 0.127-3.74
Binary weak
189.11 Malignant neoplasm of kidney, except pelvis
Malignant neoplasm of kidney, except renal pelvis
MGI PRS-CS UKB GWAS (FINNGEN) 1096344 0.054 0 0.0826 0.525
0.502-0.549
1.56
OR 95% CI: 0.751-3.26
Binary weak
193 Thyroid cancer
ICD-10 C73 Malignant neoplasm of thyroid gland
MGI Fixed threshold (5e-05) UKB GWAS (ICD10) 76 0.054 0.0067 0.0827 0.527
0.494-0.558
1.13
OR 95% CI: 0.42-3.04
Binary weak
149 Cancer of larynx, pharynx, nasal cavities
MGI PRS-CS UKB GWAS (PheCode) 1119238 0.055 0.0002 0.0827 0.525
0.5-0.55
1.5
OR 95% CI: 0.722-3.11
Binary weak
157 Pancreatic cancer
MGI Fixed threshold (5e-05) GWAS Catalog (2019-05-03) 32 0.055 0.0053 0.0827 0.532
0.491-0.573
2.46
OR 95% CI: 0.942-6.41
Binary weak
202.21 Nodular lymphoma
MGI Fixed threshold (5e-05) UKB GWAS (PheCode) 116 0.055 0.0007 0.0826 0.52
0.488-0.55
1.14
OR 95% CI: 0.371-3.53
Binary weak
202 Cancer of other lymphoid, histiocytic tissue
Marginal zone lymphoma;Waldenström macroglobulinemia / lymphoplasmacytic lymphoma (GWAS Catalog (2019-05-03))
MGI Fixed threshold (5e-07) UKB GWAS (PheCode) 6 0.056 0.0001 0.0827 0.511
0.489-0.537
0.996
OR 95% CI: 0.441-2.25
Binary weak
202.21 Nodular lymphoma
Follicular lymphoma
MGI Fixed threshold (5e-07) UKB GWAS (FINNGEN) 10 0.056 0.0003 0.0825 0.493
0.462-0.526
1.48
OR 95% CI: 0.54-4.06
Binary weak
165 Cancer within the respiratory system
MGI PRS-CS UKB GWAS (PheCode) 1119238 0.057 0.002 0.0826 0.527
0.499-0.553
0.718
OR 95% CI: 0.24-2.15
Binary weak
165.1 Cancer of bronchus; lung
ICD-10 C34 Malignant neoplasm of bronchus and lung
MGI PRS-CS UKB GWAS (ICD10) 1108949 0.057 0 0.0827 0.525
0.494-0.552
1.73
OR 95% CI: 0.786-3.81
Binary weak
153 Colorectal cancer
Cancer code, self-reported: large bowel cancer/colorectal cancer (UKB GWAS (PHESANT))
MGI GWAS Hits GWAS Catalog (2019-05-03) 18 0.058 0.0045 0.083 0.52
0.495-0.544
1.06
OR 95% CI: 0.467-2.4
Binary weak
182 Malignant neoplasm of uterus
Endometrial cancer;Endometrial cancer (endometrioid histology);Endometrial endometrioid carcinoma;Endometrial cancer (Non-endometrioid histology)
MGI GWAS Hits GWAS Catalog (2019-05-03) 18 0.061 0.0027 0.0832 0.531
0.497-0.564
1.94
OR 95% CI: 0.823-4.57
Binary weak
184.11 Malignant neoplasm of ovary
Low-grade serous and serous borderline ovarian cancer
MGI lassosum Phelan CM et al. 2017 5328 0.061 0.0091 0.0827 0.544
0.497-0.589
2.32
OR 95% CI: 0.796-6.76
Binary weak
201 Hodgkin's disease
Hodgkin lymphoma
MGI lassosum UKB GWAS (FINNGEN) 4599 0.061 0.016 0.0827 0.563
0.494-0.633
1.6
OR 95% CI: 0.249-10.2
Binary weak
191.11 Cancer of brain
Glioblastoma
MGI Fixed threshold (5e-05) GWAS Catalog (2019-05-03) 15 0.062 0.0028 0.0825 0.532
0.494-0.57
1.01
OR 95% CI: 0.268-3.8
Binary weak
191.11 Cancer of brain
Glioblastoma
MGI Fixed threshold (5e-06) GWAS Catalog (2019-05-03) 14 0.062 0.0034 0.0825 0.532
0.494-0.57
0.599
OR 95% CI: 0.112-3.2
Binary weak
204.22 Myeloid leukemia, chronic
MGI Fixed threshold (5e-06) UKB GWAS (PheCode) 9 0.062 0.006 0.0818 0.552
0.443-0.671
4.32
OR 95% CI: 0.481-38.8
Binary weak
189 Cancer of urinary organs (incl. kidney and bladder)
Malignant neoplasm of urinary organs
MGI PRS-CS UKB GWAS (FINNGEN) 1109848 0.063 0.0001 0.0975 0.513
0.498-0.53
1.14
OR 95% CI: 0.653-1.99
Binary weak
184.11 Malignant neoplasm of ovary
Invasive epithelial ovarian cancer
MGI Fixed threshold (5e-07) Phelan CM et al. 2017 23 0.064 0.0007 0.0828 0.545
0.504-0.589
0
OR 95% CI: 0-0
Binary weak
159.2 Malignant neoplasm of small intestine, including duodenum
Self-reported small intestine/small bowel cancer
MGI lassosum UKB GWAS (PHESANT) 1487304 0.066 0.0054 0.0824 0.574
0.515-0.64
0
OR 95% CI: 0-0
Binary weak
170.2 Cancer of connective tissue
MGI Fixed threshold (5e-05) UKB GWAS (PheCode) 86 0.067 0 0.0827 0.513
0.487-0.539
1.73
OR 95% CI: 0.858-3.47
Binary weak
150 Cancer of esophagus
Self-reported oesophageal cancer
MGI PRS-CS UKB GWAS (PHESANT) 934591 0.068 0.0008 0.0827 0.535
0.493-0.579
1.79
OR 95% CI: 0.556-5.77
Binary weak
204 Leukemia
MGI PRS-CS UKB GWAS (PheCode) 1119238 0.068 0.0012 0.0825 0.532
0.494-0.567
2.02
OR 95% CI: 0.793-5.15
Binary weak
180.1 Cervical cancer
Malignant neoplasm of cervix uteri
MGI lassosum UKB GWAS (FINNGEN) 243546 0.069 0.002 0.0825 0.538
0.498-0.578
1.05
OR 95% CI: 0.278-4
Binary weak
201 Hodgkin's disease
Hodgkin's lymphoma;Nodular sclerosis Hodgkin lymphoma
UKB Fixed threshold (5e-05) GWAS Catalog (2019-05-03) 20 0.069 0.054 0.0819 0.533
0.476-0.59
2.67
OR 95% CI: 0.783-9.08
Binary weak
201 Hodgkin's disease
Hodgkin's lymphoma;Nodular sclerosis Hodgkin lymphoma
UKB Fixed threshold (5e-06) GWAS Catalog (2019-05-03) 20 0.069 0.054 0.0819 0.533
0.476-0.59
2.67
OR 95% CI: 0.783-9.08
Binary weak
201 Hodgkin's disease
Hodgkin's lymphoma;Nodular sclerosis Hodgkin lymphoma
UKB P&T GWAS Catalog (2019-05-03) 20 0.069 0.054 0.0819 0.533
0.476-0.59
2.67
OR 95% CI: 0.783-9.08
Binary weak
202 Cancer of other lymphoid, histiocytic tissue
Lymphomas
MGI Fixed threshold (5e-06) UKB GWAS (FINNGEN) 30 0.071 0.0003 0.0827 0.509
0.489-0.533
0.836
OR 95% CI: 0.347-2.01
Binary weak
174.1 Breast cancer [female]
ICD-10 D05 Carcinoma in situ of breast
MGI PRS-CS UKB GWAS (ICD10) 1107790 0.073 0.0016 0.14 0.519
0.503-0.536
1.16
OR 95% CI: 0.667-2.02
Binary weak
153.2 Colon cancer
Self-reported colon cancer/sigmoid cancer
MGI PRS-CS UKB GWAS (PHESANT) 1104674 0.074 0.0016 0.0833 0.517
0.489-0.544
2.7
OR 95% CI: 1.43-5.11
Binary weak
153.3 Malignant neoplasm of rectum, rectosigmoid junction, and anus
Diagnoses - main ICD10: C21 Malignant neoplasm of anus and anal canal (UKB GWAS (ICD10))
MGI PRS-CS UKB GWAS (PheCode) 1119238 0.074 0.0006 0.0829 0.536
0.501-0.569
0.737
OR 95% CI: 0.2-2.72
Binary weak
180 Cervical cancer and dysplasia
MGI PRS-CS UKB GWAS (PheCode) 1119236 0.074 0.0003 0.0908 0.525
0.501-0.55
0.767
OR 95% CI: 0.289-2.03
Binary weak
184.11 Malignant neoplasm of ovary
Ovarian clear cell cancer
MGI lassosum Phelan CM et al. 2017 3387 0.074 0.0068 0.0828 0.539
0.495-0.586
3.04
OR 95% CI: 1.13-8.13
Binary weak
202.21 Nodular lymphoma
ICD-10 C82 Follicular [nodular] non-Hodgkin's lymphoma
MGI lassosum UKB GWAS (ICD10) 137530 0.074 0.0003 0.0826 0.506
0.473-0.539
1.82
OR 95% CI: 0.722-4.61
Binary weak
153 Colorectal cancer
Self-reported large bowel cancer/colorectal cancer
MGI PRS-CS UKB GWAS (PHESANT) 1072047 0.075 0.0009 0.083 0.523
0.499-0.547
0.717
OR 95% CI: 0.273-1.88
Binary weak
201 Hodgkin's disease
Diagnoses - main ICD10: C81 Hodgkin's disease (UKB GWAS (ICD10))
MGI Fixed threshold (5e-05) UKB GWAS (PheCode) 96 0.075 0.0025 0.0828 0.562
0.489-0.632
1.81
OR 95% CI: 0.285-11.4
Binary weak
153 Colorectal cancer
Self-reported large bowel cancer/colorectal cancer
MGI P&T UKB GWAS (PHESANT) 173 0.077 0.0009 0.083 0.516
0.493-0.538
1.05
OR 95% CI: 0.464-2.38
Binary weak
172.3 Carcinoma in situ of skin
ICD-10 D04 Carcinoma in situ of skin
MGI PRS-CS UKB GWAS (ICD10) 1065239 0.077 0.0001 0.0939 0.521
0.495-0.546
1.24
OR 95% CI: 0.57-2.72
Binary weak
153.3 Malignant neoplasm of rectum, rectosigmoid junction, and anus
Diagnoses - main ICD10: C21 Malignant neoplasm of anus and anal canal (UKB GWAS (ICD10))
MGI lassosum UKB GWAS (PheCode) 68 0.078 0.0014 0.0829 0.525
0.492-0.556
2.25
OR 95% CI: 1-5.06
Binary weak
184.11 Malignant neoplasm of ovary
Invasive epithelial ovarian cancer
MGI GWAS Hits Phelan CM et al. 2017 16 0.079 0.0004 0.0828 0.542
0.495-0.587
0.787
OR 95% CI: 0.143-4.35
Binary weak
155.1 Malignant neoplasm of liver, primary
MGI Fixed threshold (5e-05) UKB GWAS (PheCode) 79 0.08 0.0013 0.0824 0.53
0.48-0.578
1.62
OR 95% CI: 0.407-6.47
Binary weak
153.3 Malignant neoplasm of rectum, rectosigmoid junction, and anus
ICD-10 C19 Malignant neoplasm of rectosigmoid junction
MGI lassosum UKB GWAS (ICD10) 2154790 0.081 0.0007 0.0829 0.53
0.498-0.563
0.441
OR 95% CI: 0.0841-2.31
Binary weak
172.2 Other non-epithelial cancer of skin
Self-reported non-melanoma skin cancer
MGI PRS-CS UKB GWAS (PHESANT) 1075656 0.081 0.0019 0.139 0.509
0.497-0.522
1.32
OR 95% CI: 0.898-1.93
Binary weak
182 Malignant neoplasm of uterus
Endometrial cancer;Endometrial cancer (endometrioid histology);Endometrial endometrioid carcinoma;Endometrial cancer (Non-endometrioid histology)
MGI P&T GWAS Catalog (2019-05-03) 31 0.081 0.0049 0.0832 0.521
0.49-0.551
1.04
OR 95% CI: 0.34-3.19
Binary weak
189.2 Cancer of bladder
ICD-10 C67 Malignant neoplasm of bladder
MGI PRS-CS UKB GWAS (ICD10) 1109663 0.081 0.0018 0.0922 0.517
0.495-0.539
1.52
OR 95% CI: 0.806-2.87
Binary weak
159 Malignant neoplasm of other and ill-defined sites within the digestive organs and peritoneum
Malignant neoplasm of digestive organs
MGI Fixed threshold (5e-07) UKB GWAS (FINNGEN) 6 0.082 0.0006 0.0826 0.503
0.472-0.532
1.38
OR 95% CI: 0.556-3.41
Binary weak
180.3 Cervical intraepithelial neoplasia [CIN] [Cervical dysplasia]
Self-reported cin/pre-cancer cells cervix
MGI Fixed threshold (5e-05) UKB GWAS (PHESANT) 132 0.084 0.0002 0.0885 0.519
0.49-0.548
1.25
OR 95% CI: 0.504-3.09
Binary weak
191.11 Cancer of brain
Malignant neoplasm of brain
MGI Fixed threshold (5e-07) UKB GWAS (FINNGEN) 6 0.084 0.0003 0.0825 0.534
0.497-0.572
1.01
OR 95% CI: 0.268-3.82
Binary weak
202.21 Nodular lymphoma
ICD-10 C82 Follicular [nodular] non-Hodgkin's lymphoma
MGI Fixed threshold (5e-05) UKB GWAS (ICD10) 91 0.085 0.0002 0.0826 0.518
0.486-0.553
1.47
OR 95% CI: 0.537-4.04
Binary weak
184.11 Malignant neoplasm of ovary
High-grade serous ovarian cancer
UKB P&T Phelan CM et al. 2017 88 0.086 0.0019 0.0827 0.523
0.494-0.551
0.924
OR 95% CI: 0.348-2.46
Binary weak
191.1 Cancer of brain and nervous system
Malignant neoplasm of eye, brain and central nervous system
MGI Fixed threshold (5e-05) UKB GWAS (FINNGEN) 105 0.086 0.0001 0.0826 0.526
0.488-0.561
1.22
OR 95% CI: 0.394-3.79
Binary weak
159.2 Malignant neoplasm of small intestine, including duodenum
Malignant neoplasm of small intestine
MGI Fixed threshold (5e-06) UKB GWAS (FINNGEN) 7 0.087 0.0002 0.0824 0.549
0.478-0.616
0
OR 95% CI: 0-0
Binary weak
153 Colorectal cancer
Cancer code, self-reported: large bowel cancer/colorectal cancer (UKB GWAS (PHESANT))
MGI Fixed threshold (5e-07) GWAS Catalog (2019-05-03) 22 0.088 0.0047 0.083 0.515
0.49-0.538
2.04
OR 95% CI: 1.1-3.79
Binary weak
149.4 Cancer of larynx
Malignant neoplasm of larynx
MGI Fixed threshold (5e-05) UKB GWAS (FINNGEN) 65 0.092 0.0004 0.0825 0.521
0.476-0.565
4.7
OR 95% CI: 1.91-11.5
Binary weak
174.1 Breast cancer [female]
ICD-10 D05 Carcinoma in situ of breast
MGI lassosum UKB GWAS (ICD10) 29211 0.093 0.0034 0.14 0.515
0.498-0.532
1.36
OR 95% CI: 0.802-2.32
Binary weak
193 Thyroid cancer
ICD-10 C73 Malignant neoplasm of thyroid gland
MGI Fixed threshold (5e-06) UKB GWAS (ICD10) 15 0.093 0.008 0.0827 0.514
0.483-0.546
2.42
OR 95% CI: 1.17-4.98
Binary weak
201 Hodgkin's disease
Diagnoses - main ICD10: C81 Hodgkin's disease (UKB GWAS (ICD10))
MGI Fixed threshold (5e-06) UKB GWAS (PheCode) 7 0.093 0.0018 0.0828 0.508
0.434-0.589
6.71
OR 95% CI: 2.12-21.2
Binary weak
150 Cancer of esophagus
Malignant neoplasm of oesophagus
MGI P&T UKB GWAS (FINNGEN) 143 0.094 0.0019 0.0827 0.538
0.492-0.577
0
OR 95% CI: 0-0
Binary weak
184.11 Malignant neoplasm of ovary
Low-grade serous ovarian cancer
UKB Fixed threshold (5e-06) Phelan CM et al. 2017 15 0.094 0.0001 0.0827 0.521
0.493-0.547
0.717
OR 95% CI: 0.239-2.15
Binary weak
191.11 Cancer of brain
ICD-10 C71 Malignant neoplasm of brain
MGI Fixed threshold (5e-05) UKB GWAS (ICD10) 89 0.094 0.0005 0.0825 0.522
0.481-0.559
2.62
OR 95% CI: 1.08-6.39
Binary weak
153 Colorectal cancer
Cancer code, self-reported: large bowel cancer/colorectal cancer (UKB GWAS (PHESANT))
MGI Fixed threshold (5e-05) GWAS Catalog (2019-05-03) 27 0.095 0.0048 0.083 0.516
0.492-0.538
1.89
OR 95% CI: 0.998-3.59
Binary weak
153 Colorectal cancer
Cancer code, self-reported: large bowel cancer/colorectal cancer (UKB GWAS (PHESANT))
MGI P&T GWAS Catalog (2019-05-03) 27 0.095 0.0048 0.083 0.516
0.492-0.538
1.89
OR 95% CI: 0.998-3.59
Binary weak
184.11 Malignant neoplasm of ovary
Serous invasive ovarian cancer
MGI Fixed threshold (5e-05) Phelan CM et al. 2017 207 0.095 0.0027 0.0828 0.552
0.506-0.59
0.797
OR 95% CI: 0.145-4.4
Binary weak
204 Leukemia
MGI lassosum UKB GWAS (PheCode) 35027 0.095 0.0027 0.0825 0.523
0.49-0.558
2.3
OR 95% CI: 0.959-5.51
Binary weak
153 Colorectal cancer
Cancer code, self-reported: large bowel cancer/colorectal cancer (UKB GWAS (PHESANT))
MGI Fixed threshold (5e-06) GWAS Catalog (2019-05-03) 26 0.096 0.0047 0.083 0.515
0.491-0.538
2.05
OR 95% CI: 1.11-3.81
Binary weak
204 Leukemia
MGI Fixed threshold (5e-05) UKB GWAS (PheCode) 129 0.096 0.0007 0.0825 0.528
0.492-0.566
1.23
OR 95% CI: 0.397-3.82
Binary weak
145.2 Cancer of tongue
ICD-10 C02 Malignant neoplasm of other and unspecified parts of tongue
MGI lassosum UKB GWAS (ICD10) 2318649 0.097 0.0015 0.0828 0.535
0.496-0.571
0
OR 95% CI: 0-0
Binary weak
153.3 Malignant neoplasm of rectum, rectosigmoid junction, and anus
Malignant neoplasm of rectosigmoid junction
MGI PRS-CS UKB GWAS (FINNGEN) 1040423 0.097 0.0004 0.0829 0.533
0.503-0.565
0.441
OR 95% CI: 0.0841-2.31
Binary weak
189.11 Malignant neoplasm of kidney, except pelvis
Renal cell carcinoma;Wilms tumor (GWAS Catalog (2019-05-03))
MGI P&T UKB GWAS (PheCode) 11 0.097 0.0013 0.0827 0.495
0.47-0.518
1.95
OR 95% CI: 0.998-3.82
Binary weak
202.21 Nodular lymphoma
Follicular lymphoma
MGI Fixed threshold (5e-09) UKB GWAS (FINNGEN) 5 0.097 0.0001 0.0826 0.474
0.442-0.506
1.81
OR 95% CI: 0.716-4.58
Binary weak
199.4 Neurofibromatosis
MGI Fixed threshold (5e-05) UKB GWAS (PheCode) 59 0.099 0.0002 0.082 0.546
0.437-0.652
5.49
OR 95% CI: 0.98-30.8
Binary weak
204.4 Multiple myeloma
Self-reported multiple myeloma
MGI Fixed threshold (5e-06) UKB GWAS (PHESANT) 5 0.099 0.0051 0.0824 0.539
0.467-0.61
2.28
OR 95% CI: 0.515-10.1
Binary weak
153.2 Colon cancer
Malignant neoplasm of colon
MGI P&T UKB GWAS (FINNGEN) 18 0.1 0.0016 0.0833 0.513
0.485-0.541
1.18
OR 95% CI: 0.482-2.9
Binary weak
159.4 Malignant neoplasm of retroperitoneum and peritoneum
ICD-10 C48 Malignant neoplasm of retroperitoneum and peritoneum
MGI PRS-CS UKB GWAS (ICD10) 906432 0.1 0 0.0825 0.544
0.49-0.598
1.1
OR 95% CI: 0.191-6.32
Binary weak
182 Malignant neoplasm of uterus
Endometrial cancer;Endometrial cancer (endometrioid histology);Endometrial endometrioid carcinoma;Endometrial cancer (Non-endometrioid histology)
MGI Fixed threshold (5e-07) GWAS Catalog (2019-05-03) 28 0.1 0.0034 0.0832 0.523
0.49-0.556
1.96
OR 95% CI: 0.831-4.63
Binary weak
184 Cancer of other female genital organs
malignant neoplasm of female genital organs
MGI lassosum UKB GWAS (FINNGEN) 6 0.1 0.0017 0.0837 0.464
0.44-0.491
1.65
OR 95% CI: 0.753-3.62
Binary weak
184.11 Malignant neoplasm of ovary
Epithelial ovarian cancer
UKB Fixed threshold (5e-06) Phelan CM et al. 2017 26 0.1 0.0036 0.0827 0.532
0.506-0.557
0.716
OR 95% CI: 0.239-2.14
Binary weak
184.11 Malignant neoplasm of ovary
Epithelial ovarian cancer
UKB P&T Phelan CM et al. 2017 40 0.1 0.0048 0.0827 0.526
0.5-0.554
1.34
OR 95% CI: 0.584-3.07
Binary weak
202 Cancer of other lymphoid, histiocytic tissue
Marginal zone lymphoma;Waldenström macroglobulinemia / lymphoplasmacytic lymphoma (GWAS Catalog (2019-05-03))
MGI P&T UKB GWAS (PheCode) 10 0.1 0.0004 0.0827 0.51
0.487-0.533
1.28
OR 95% CI: 0.623-2.65
Binary weak
149.4 Cancer of larynx
Diagnoses - main ICD10: C32 Malignant neoplasm of larynx (UKB GWAS (ICD10))
MGI lassosum UKB GWAS (PheCode) 175596 0.11 0.0028 0.0825 0.534
0.486-0.578
2.14
OR 95% CI: 0.649-7.03
Binary weak
153.2 Colon cancer
Malignant neoplasm of colon
MGI Fixed threshold (5e-06) UKB GWAS (FINNGEN) 25 0.11 0.0002 0.0833 0.508
0.481-0.536
1.16
OR 95% CI: 0.473-2.84
Binary weak
153.2 Colon cancer
ICD-10 C18 Malignant neoplasm of colon
MGI P&T UKB GWAS (ICD10) 5 0.11 0.0022 0.0833 0.508
0.482-0.535
1.16
OR 95% CI: 0.475-2.85
Binary weak
157 Pancreatic cancer
MGI Fixed threshold (5e-06) GWAS Catalog (2019-05-03) 30 0.11 0.006 0.0828 0.526
0.486-0.567
1.54
OR 95% CI: 0.486-4.87
Binary weak
157 Pancreatic cancer
MGI Fixed threshold (5e-07) GWAS Catalog (2019-05-03) 21 0.11 0.012 0.0828 0.533
0.492-0.575
1.1
OR 95% CI: 0.287-4.18
Binary weak
165 Cancer within the respiratory system
ICD-10 C45 Mesothelioma
MGI lassosum UKB GWAS (ICD10) 3360952 0.11 0.002 0.0827 0.52
0.495-0.548
1.13
OR 95% CI: 0.463-2.77
Binary weak
189.11 Malignant neoplasm of kidney, except pelvis
Renal cell carcinoma;Wilms tumor (GWAS Catalog (2019-05-03))
MGI Fixed threshold (5e-05) UKB GWAS (PheCode) 81 0.11 0 0.0827 0.508
0.481-0.533
1.74
OR 95% CI: 0.864-3.5
Binary weak
191.11 Cancer of brain
Glioblastoma (GWAS Catalog (2019-05-03))
MGI PRS-CS UKB GWAS (PheCode) 1119238 0.11 0.0006 0.0825 0.527
0.487-0.567
1.04
OR 95% CI: 0.274-3.91
Binary weak
193 Thyroid cancer
Self-reported thyroid cancer
MGI PRS-CS UKB GWAS (PHESANT) 1042118 0.11 0.0002 0.0827 0.526
0.497-0.558
2.16
OR 95% CI: 1.01-4.6
Binary weak
202.24 Large cell lymphoma
MGI P&T UKB GWAS (PheCode) 7 0.11 0.0328 0.0829 0.548
0.485-0.616
2
OR 95% CI: 0.305-13.1
Binary weak
204.4 Multiple myeloma
and malignant plasma cell neoplasms
MGI Fixed threshold (5e-05) UKB GWAS (FINNGEN) 85 0.11 0.0002 0.0825 0.548
0.481-0.609
0
OR 95% CI: 0-0
Binary weak
145 Cancer of mouth
Malignant neoplasm of lip, oral cavity and pharynx
MGI PRS-CS UKB GWAS (FINNGEN) 1092985 0.12 0 0.0829 0.518
0.494-0.544
1.28
OR 95% CI: 0.595-2.78
Binary weak
153.3 Malignant neoplasm of rectum, rectosigmoid junction, and anus
Malignant neoplasm of anus and anal canal
MGI PRS-CS UKB GWAS (FINNGEN) 877060 0.12 0.0006 0.0829 0.528
0.495-0.562
1.33
OR 95% CI: 0.487-3.61
Binary weak
165 Cancer within the respiratory system
Malignant neoplasm of respiratory system and intrathoracic organs
MGI lassosum UKB GWAS (FINNGEN) 1898 0.12 0.0012 0.0827 0.523
0.495-0.549
0.927
OR 95% CI: 0.349-2.47
Binary weak
165.1 Cancer of bronchus; lung
Malignant neoplasm of bronchus and lung
MGI lassosum UKB GWAS (FINNGEN) 380802 0.12 0.0008 0.0827 0.521
0.493-0.548
1.75
OR 95% CI: 0.795-3.85
Binary weak
189.2 Cancer of bladder
ICD-10 C67 Malignant neoplasm of bladder
MGI P&T UKB GWAS (ICD10) 10 0.12 0.0006 0.0922 0.504
0.483-0.524
1.1
OR 95% CI: 0.534-2.26
Binary weak
189.2 Cancer of bladder
Self-reported bladder cancer
MGI lassosum UKB GWAS (PHESANT) 29094 0.12 0.002 0.0922 0.516
0.497-0.536
0.943
OR 95% CI: 0.439-2.02
Binary weak
190 Cancer of eye
Malignant neoplasm of eye and adnexa (UKB GWAS (FINNGEN))
MGI lassosum UKB GWAS (PheCode) 2397847 0.12 0.011 0.0834 0.547
0.473-0.62
1.93
OR 95% CI: 0.297-12.5
Binary weak
191.11 Cancer of brain
ICD-10 C71 Malignant neoplasm of brain
MGI P&T UKB GWAS (ICD10) 29 0.12 0.0033 0.0825 0.528
0.486-0.571
2.26
OR 95% CI: 0.875-5.84
Binary weak
191.11 Cancer of brain
Glioblastoma (GWAS Catalog (2019-05-03))
MGI lassosum UKB GWAS (PheCode) 1621 0.12 0.0031 0.0826 0.538
0.501-0.576
1.01
OR 95% CI: 0.268-3.82
Binary weak
193 Thyroid cancer
ICD-10 C73 Malignant neoplasm of thyroid gland
MGI lassosum UKB GWAS (ICD10) 3017 0.12 0.0038 0.0828 0.523
0.491-0.556
1.14
OR 95% CI: 0.422-3.05
Binary weak
199.4 Neurofibromatosis
MGI Fixed threshold (5e-06) UKB GWAS (PheCode) 5 0.12 0.0181 0.0822 0.519
0.433-0.622
3.4
OR 95% CI: 0.421-27.4
Binary weak
199.4 Neurofibromatosis
MGI P&T UKB GWAS (PheCode) 5 0.12 0.0181 0.0822 0.519
0.433-0.622
3.4
OR 95% CI: 0.421-27.4
Binary weak
202.21 Nodular lymphoma
MGI P&T UKB GWAS (PheCode) 207 0.12 0.0018 0.0826 0.518
0.483-0.55
0.814
OR 95% CI: 0.22-3.02
Binary weak
204.4 Multiple myeloma
(hyperdiploidy);Multiple myeloma (IgH translocation);Multiple myeloma;Multiple myeloma and monoclonal gammopathy
UKB Fixed threshold (5e-05) GWAS Catalog (2019-05-03) 54 0.12 0.0064 0.0823 0.521
0.483-0.562
2.18
OR 95% CI: 0.848-5.6
Binary weak
157 Pancreatic cancer
MGI Fixed threshold (5e-09) GWAS Catalog (2019-05-03) 10 0.13 0.0107 0.0828 0.52
0.48-0.56
1.08
OR 95% CI: 0.284-4.12
Binary weak
182 Malignant neoplasm of uterus
Endometrial cancer;Endometrial cancer (endometrioid histology);Endometrial endometrioid carcinoma;Endometrial cancer (Non-endometrioid histology)
MGI Fixed threshold (5e-05) GWAS Catalog (2019-05-03) 34 0.13 0.0019 0.0832 0.516
0.482-0.547
1.04
OR 95% CI: 0.339-3.19
Binary weak
182 Malignant neoplasm of uterus
Endometrial cancer;Endometrial cancer (endometrioid histology);Endometrial endometrioid carcinoma;Endometrial cancer (Non-endometrioid histology)
MGI Fixed threshold (5e-06) GWAS Catalog (2019-05-03) 34 0.13 0.0019 0.0832 0.516
0.482-0.547
1.04
OR 95% CI: 0.339-3.19
Binary weak
184.11 Malignant neoplasm of ovary
Mucinous ovarian carcinoma
MGI Fixed threshold (5e-05) Phelan CM et al. 2017 131 0.13 0.0007 0.0828 0.529
0.487-0.571
1.81
OR 95% CI: 0.556-5.91
Binary weak
187 Cancer of other male genital organs
malignant neoplasm of male genital organs
MGI Fixed threshold (5e-05) UKB GWAS (FINNGEN) 276 0.13 0.0007 0.0832 0.539
0.485-0.591
1
OR 95% CI: 0.175-5.71
Binary weak
190 Cancer of eye
ICD-10 C69 Malignant neoplasm of eye and adnexa
MGI PRS-CS UKB GWAS (ICD10) 911547 0.13 0.0011 0.0834 0.545
0.47-0.613
4.58
OR 95% CI: 1.17-17.9
Binary weak
193 Thyroid cancer
ICD-10 C73 Malignant neoplasm of thyroid gland
MGI PRS-CS UKB GWAS (ICD10) 1027375 0.13 0.0001 0.0828 0.527
0.498-0.558
0.377
OR 95% CI: 0.0725-1.96
Binary weak
201 Hodgkin's disease
Diagnoses - main ICD10: C81 Hodgkin's disease (UKB GWAS (ICD10))
MGI PRS-CS UKB GWAS (PheCode) 1119238 0.13 0.0053 0.0829 0.554
0.485-0.622
0
OR 95% CI: 0-0
Binary weak
202.21 Nodular lymphoma
Follicular lymphoma
MGI GWAS Hits UKB GWAS (FINNGEN) 6 0.13 0.0002 0.0826 0.476
0.444-0.508
1.82
OR 95% CI: 0.719-4.59
Binary weak
204.1 Lymphoid leukemia
MGI Fixed threshold (5e-06) UKB GWAS (PheCode) 25 0.13 0.0079 0.0824 0.528
0.463-0.593
1.59
OR 95% CI: 0.259-9.81
Binary weak
145.2 Cancer of tongue
Malignant neoplasm of other and unspecified parts of tongue
MGI lassosum UKB GWAS (FINNGEN) 12655 0.14 0.0041 0.0828 0.523
0.489-0.558
2.09
OR 95% CI: 0.815-5.34
Binary weak
165 Cancer within the respiratory system
Malignant neoplasm of respiratory system and intrathoracic organs
MGI Fixed threshold (5e-05) UKB GWAS (FINNGEN) 136 0.14 0.0015 0.0827 0.515
0.489-0.541
0.504
OR 95% CI: 0.14-1.82
Binary weak
165 Cancer within the respiratory system
Malignant neoplasm of respiratory system and intrathoracic organs
MGI P&T UKB GWAS (FINNGEN) 136 0.14 0.0015 0.0827 0.515
0.489-0.541
0.504
OR 95% CI: 0.14-1.82
Binary weak
165 Cancer within the respiratory system
Mesothelioma
MGI lassosum UKB GWAS (FINNGEN) 3382118 0.14 0.0021 0.0827 0.519
0.493-0.547
1.14
OR 95% CI: 0.466-2.79
Binary weak
184.11 Malignant neoplasm of ovary
Invasive epithelial ovarian cancer
MGI PRS-CS Phelan CM et al. 2017 1114056 0.14 0.002 0.0828 0.537
0.494-0.582
1.87
OR 95% CI: 0.576-6.07
Binary weak
184.11 Malignant neoplasm of ovary
Ovarian clear cell cancer
UKB Fixed threshold (5e-05) Phelan CM et al. 2017 100 0.14 0.0016 0.0827 0.518
0.491-0.546
1.34
OR 95% CI: 0.584-3.07
Binary weak
184.11 Malignant neoplasm of ovary
Epithelial ovarian cancer
UKB PRS-CS Phelan CM et al. 2017 1115189 0.14 0.0006 0.0827 0.516
0.488-0.546
2.4
OR 95% CI: 1.25-4.62
Binary weak
187 Cancer of other male genital organs
malignant neoplasm of male genital organs
MGI Fixed threshold (5e-09) UKB GWAS (FINNGEN) 36 0.14 0.0003 0.0832 0.536
0.482-0.587
2.31
OR 95% CI: 0.684-7.82
Binary weak
193 Thyroid cancer
Self-reported thyroid cancer
MGI lassosum UKB GWAS (PHESANT) 1515 0.14 0.0023 0.0828 0.518
0.488-0.549
1.39
OR 95% CI: 0.559-3.43
Binary weak
201 Hodgkin's disease
Hodgkin lymphoma
MGI PRS-CS UKB GWAS (FINNGEN) 1007370 0.14 0.0023 0.0828 0.57
0.493-0.644
3.02
OR 95% CI: 0.674-13.5
Binary weak
202 Cancer of other lymphoid, histiocytic tissue
Lymphomas
MGI Fixed threshold (5e-05) UKB GWAS (FINNGEN) 140 0.14 0.0008 0.0827 0.511
0.489-0.534
0.835
OR 95% CI: 0.347-2.01
Binary weak
202.21 Nodular lymphoma
ICD-10 C82 Follicular [nodular] non-Hodgkin's lymphoma
MGI Fixed threshold (5e-09) UKB GWAS (ICD10) 6 0.14 0.0002 0.0826 0.477
0.447-0.509
1.81
OR 95% CI: 0.715-4.56
Binary weak
202.21 Nodular lymphoma
MGI Fixed threshold (5e-09) UKB GWAS (PheCode) 7 0.14 0.0003 0.0826 0.475
0.443-0.509
1.48
OR 95% CI: 0.539-4.05
Binary weak
202.21 Nodular lymphoma
ICD-10 C82 Follicular [nodular] non-Hodgkin's lymphoma
MGI GWAS Hits UKB GWAS (ICD10) 6 0.14 0.0002 0.0826 0.477
0.447-0.509
1.81
OR 95% CI: 0.715-4.56
Binary weak
204.12 Lymphoid leukemia, chronic
Chronic lymphocytic leukemia (GWAS Catalog (2019-05-03))
MGI Fixed threshold (5e-05) UKB GWAS (PheCode) 125 0.14 0.0001 0.0827 0.546
0.476-0.615
3.51
OR 95% CI: 0.747-16.5
Binary weak
145.2 Cancer of tongue
ICD-10 C02 Malignant neoplasm of other and unspecified parts of tongue
MGI Fixed threshold (5e-06) UKB GWAS (ICD10) 7 0.15 0.0003 0.0828 0.515
0.479-0.553
3.25
OR 95% CI: 1.47-7.19
Binary weak
145.2 Cancer of tongue
ICD-10 C02 Malignant neoplasm of other and unspecified parts of tongue
MGI PRS-CS UKB GWAS (ICD10) 951586 0.15 0.0006 0.0828 0.526
0.49-0.563
1.68
OR 95% CI: 0.606-4.68
Binary weak
150 Cancer of esophagus
ICD-10 C15 Malignant neoplasm of oesophagus
MGI P&T UKB GWAS (ICD10) 62 0.15 0.0029 0.0827 0.532
0.486-0.57
1.27
OR 95% CI: 0.329-4.91
Binary weak
172.22 Squamous cell carcinoma
Self-reported squamous cell carcinoma
MGI PRS-CS UKB GWAS (PHESANT) 1064109 0.15 0.0002 0.0997 0.512
0.493-0.532
1.67
OR 95% CI: 0.961-2.89
Binary weak
180.1 Cervical cancer
Self-reported cervical cancer
MGI Fixed threshold (5e-07) UKB GWAS (PHESANT) 5 0.15 0.0037 0.0825 0.519
0.483-0.555
1.52
OR 95% CI: 0.48-4.8
Binary weak
180.1 Cervical cancer
Self-reported cervical cancer
MGI P&T UKB GWAS (PHESANT) 5 0.15 0.0037 0.0825 0.519
0.483-0.555
1.52
OR 95% CI: 0.48-4.8
Binary weak
184.11 Malignant neoplasm of ovary
Epithelial ovarian cancer;High-grade serous ovarian cancer;Serous invasive ovarian cancer;Invasive epithelial ovarian cancer;Mucinous ovarian carcinoma;Low-grade serous and serous borderline ovarian cancer;Serous borderline ovarian cancer;Ovarian cancer in BRCA1 mutation carriers;Ovarian cancer;Ovarian clear cell cancer
MGI Fixed threshold (5e-05) GWAS Catalog (2019-05-03) 25 0.15 0.0018 0.0828 0.532
0.484-0.58
1.37
OR 95% CI: 0.351-5.35
Binary weak
184.11 Malignant neoplasm of ovary
Epithelial ovarian cancer;High-grade serous ovarian cancer;Serous invasive ovarian cancer;Invasive epithelial ovarian cancer;Mucinous ovarian carcinoma;Low-grade serous and serous borderline ovarian cancer;Serous borderline ovarian cancer;Ovarian cancer in BRCA1 mutation carriers;Ovarian cancer;Ovarian clear cell cancer
MGI Fixed threshold (5e-06) GWAS Catalog (2019-05-03) 25 0.15 0.0018 0.0828 0.532
0.484-0.58
1.37
OR 95% CI: 0.351-5.35
Binary weak
189.11 Malignant neoplasm of kidney, except pelvis
Renal cell carcinoma;Wilms tumor
MGI GWAS Hits GWAS Catalog (2019-05-03) 12 0.15 0.0008 0.0827 0.493
0.467-0.517
1.58
OR 95% CI: 0.758-3.3
Binary weak
189.11 Malignant neoplasm of kidney, except pelvis
Renal cell carcinoma;Wilms tumor
MGI P&T GWAS Catalog (2019-05-03) 12 0.15 0.0008 0.0827 0.493
0.467-0.517
1.58
OR 95% CI: 0.758-3.3
Binary weak
190 Cancer of eye
Self-reported eye and/or adnexal cancer
MGI lassosum UKB GWAS (PHESANT) 19193 0.15 0.0047 0.0835 0.561
0.485-0.636
0
OR 95% CI: 0-0
Binary weak
204.4 Multiple myeloma
(hyperdiploidy);Multiple myeloma (IgH translocation);Multiple myeloma;Multiple myeloma and monoclonal gammopathy
MGI GWAS Hits GWAS Catalog (2019-05-03) 22 0.15 0.0081 0.0826 0.536
0.473-0.598
4.92
OR 95% CI: 1.48-16.4
Binary weak
204.4 Multiple myeloma
ICD-10 C90 Multiple myeloma and malignant plasma cell neoplasms
MGI PRS-CS UKB GWAS (ICD10) 1064537 0.15 0.0002 0.0826 0.554
0.489-0.616
2.51
OR 95% CI: 0.571-11
Binary weak
165 Cancer within the respiratory system
Mesothelioma
MGI PRS-CS UKB GWAS (FINNGEN) 938343 0.16 0.0011 0.0827 0.518
0.49-0.546
1.14
OR 95% CI: 0.466-2.79
Binary weak
165.1 Cancer of bronchus; lung
Lung cancer in ever smokers;Squamous cell lung carcinoma;Lung adenocarcinoma;Lung cancer;Lung cancer in never smokers;Familial squamous cell lung carcinoma;Familial lung adenocarcinoma;Familial lung cancer;Small cell lung carcinoma (GWAS Catalog (2019-05-03))
MGI Fixed threshold (5e-06) UKB GWAS (PheCode) 18 0.16 0 0.0827 0.501
0.471-0.531
1.26
OR 95% CI: 0.512-3.1
Binary weak
170 Cancer of bone and connective tissue
MGI lassosum UKB GWAS (PheCode) 245000 0.16 0.0016 0.083 0.515
0.495-0.535
0.827
OR 95% CI: 0.369-1.85
Binary weak
172.1 Melanomas of skin, dx or hx
ICD-10 D03 Melanoma in situ
MGI PRS-CS UKB GWAS (ICD10) 1080882 0.16 0.0017 0.0969 0.513
0.496-0.529
1.18
OR 95% CI: 0.697-2
Binary weak
184.11 Malignant neoplasm of ovary
Epithelial ovarian cancer;High-grade serous ovarian cancer;Serous invasive ovarian cancer;Invasive epithelial ovarian cancer;Mucinous ovarian carcinoma;Low-grade serous and serous borderline ovarian cancer;Serous borderline ovarian cancer;Ovarian cancer in BRCA1 mutation carriers;Ovarian cancer;Ovarian clear cell cancer
MGI Fixed threshold (5e-07) GWAS Catalog (2019-05-03) 23 0.16 0.0016 0.0828 0.531
0.481-0.578
1.36
OR 95% CI: 0.35-5.32
Binary weak
189.11 Malignant neoplasm of kidney, except pelvis
Self-reported kidney/renal cell cancer
MGI lassosum UKB GWAS (PHESANT) 4720259 0.16 0.001 0.0827 0.512
0.486-0.538
1.2
OR 95% CI: 0.528-2.75
Binary weak
201 Hodgkin's disease
Hodgkin's lymphoma;Nodular sclerosis Hodgkin lymphoma
UKB Fixed threshold (5e-07) GWAS Catalog (2019-05-03) 19 0.16 0.0483 0.082 0.522
0.466-0.58
2.67
OR 95% CI: 0.784-9.09
Binary weak
202 Cancer of other lymphoid, histiocytic tissue
Non-follicular lymphoma
MGI Fixed threshold (5e-05) UKB GWAS (FINNGEN) 123 0.16 0.0004 0.0827 0.512
0.489-0.535
0.826
OR 95% CI: 0.343-1.99
Binary weak
204.1 Lymphoid leukemia
MGI PRS-CS UKB GWAS (PheCode) 1119238 0.16 0.0006 0.0824 0.532
0.466-0.601
3.82
OR 95% CI: 1.02-14.3
Binary weak
204.11 Lymphoid leukemia, acute
Acute lymphoblastic leukemia (childhood);Acute lymphoblastic leukemia (B-cell precursor);Acute lymphoblastic leukemia in childhood (B cell precursor)
MGI Fixed threshold (5e-05) GWAS Catalog (2019-05-03) 25 0.16 0.0053 0.0824 0.581
0.478-0.679
0
OR 95% CI: 0-0
Binary weak
204.12 Lymphoid leukemia, chronic
Chronic lymphocytic leukemia (GWAS Catalog (2019-05-03))
MGI PRS-CS UKB GWAS (PheCode) 1119238 0.16 0 0.0826 0.557
0.482-0.634
1.91
OR 95% CI: 0.294-12.5
Binary weak
149.4 Cancer of larynx
Diagnoses - main ICD10: C32 Malignant neoplasm of larynx (UKB GWAS (ICD10))
MGI Fixed threshold (5e-05) UKB GWAS (PheCode) 72 0.17 0.0005 0.0826 0.53
0.484-0.577
1.52
OR 95% CI: 0.385-5.97
Binary weak
150 Cancer of esophagus
Self-reported oesophageal cancer
MGI Fixed threshold (5e-06) UKB GWAS (PHESANT) 10 0.17 0.0032 0.0827 0.52
0.478-0.565
0.764
OR 95% CI: 0.14-4.16
Binary weak
153.3 Malignant neoplasm of rectum, rectosigmoid junction, and anus
ICD-10 C19 Malignant neoplasm of rectosigmoid junction
MGI Fixed threshold (5e-05) UKB GWAS (ICD10) 102 0.17 0.0006 0.0829 0.522
0.49-0.555
1.33
OR 95% CI: 0.49-3.63
Binary weak
172.2 Other non-epithelial cancer of skin
Self-reported non-melanoma skin cancer
MGI lassosum UKB GWAS (PHESANT) 4882215 0.17 0.0013 0.139 0.509
0.497-0.521
0.944
OR 95% CI: 0.61-1.46
Binary weak
180.3 Cervical intraepithelial neoplasia [CIN] [Cervical dysplasia]
Self-reported cin/pre-cancer cells cervix
MGI lassosum UKB GWAS (PHESANT) 5850633 0.17 0.0049 0.0885 0.525
0.496-0.555
0.801
OR 95% CI: 0.265-2.43
Binary weak
184.11 Malignant neoplasm of ovary
Serous invasive ovarian cancer
MGI Fixed threshold (5e-06) Phelan CM et al. 2017 58 0.17 0.0015 0.0829 0.535
0.491-0.577
0
OR 95% CI: 0-0
Binary weak
184.11 Malignant neoplasm of ovary
Mucinous ovarian carcinoma
MGI Fixed threshold (5e-07) Phelan CM et al. 2017 8 0.17 0.0012 0.0829 0.532
0.487-0.578
2.43
OR 95% CI: 0.84-7.05
Binary weak
184.11 Malignant neoplasm of ovary
Epithelial ovarian cancer;High-grade serous ovarian cancer;Serous invasive ovarian cancer;Invasive epithelial ovarian cancer;Mucinous ovarian carcinoma;Low-grade serous and serous borderline ovarian cancer;Serous borderline ovarian cancer;Ovarian cancer in BRCA1 mutation carriers;Ovarian cancer;Ovarian clear cell cancer
MGI GWAS Hits GWAS Catalog (2019-05-03) 21 0.17 0.0028 0.0829 0.533
0.485-0.58
1.37
OR 95% CI: 0.351-5.34
Binary weak
184.11 Malignant neoplasm of ovary
Self-reported ovarian cancer
MGI lassosum UKB GWAS (PHESANT) 214 0.17 0.0018 0.0829 0.531
0.485-0.573
4.14
OR 95% CI: 1.72-9.98
Binary weak
189.1 Cancer of kidney and renal pelvis
MGI Fixed threshold (5e-06) UKB GWAS (PheCode) 9 0.17 0 0.0827 0.488
0.464-0.512
1.84
OR 95% CI: 0.973-3.49
Binary weak
189.11 Malignant neoplasm of kidney, except pelvis
Renal cell carcinoma;Wilms tumor
MGI Fixed threshold (5e-05) GWAS Catalog (2019-05-03) 13 0.17 0.0007 0.0827 0.492
0.466-0.516
1.78
OR 95% CI: 0.882-3.59
Binary weak
189.11 Malignant neoplasm of kidney, except pelvis
Renal cell carcinoma;Wilms tumor
MGI Fixed threshold (5e-06) GWAS Catalog (2019-05-03) 13 0.17 0.0007 0.0827 0.492
0.466-0.516
1.78
OR 95% CI: 0.882-3.59
Binary weak
189.11 Malignant neoplasm of kidney, except pelvis
Renal cell carcinoma;Wilms tumor
MGI Fixed threshold (5e-07) GWAS Catalog (2019-05-03) 13 0.17 0.0007 0.0827 0.492
0.466-0.516
1.78
OR 95% CI: 0.882-3.59
Binary weak
204.4 Multiple myeloma
ICD-10 C90 Multiple myeloma and malignant plasma cell neoplasms
MGI Fixed threshold (5e-06) UKB GWAS (ICD10) 19 0.17 0.0004 0.0826 0.534
0.469-0.598
1.52
OR 95% CI: 0.247-9.34
Binary weak
204.4 Multiple myeloma
and malignant plasma cell neoplasms
MGI lassosum UKB GWAS (FINNGEN) 31983 0.17 0.006 0.0826 0.544
0.477-0.618
1.55
OR 95% CI: 0.252-9.5
Binary weak
170.2 Cancer of connective tissue
Self-reported sarcoma/fibrosarcoma
MGI lassosum UKB GWAS (PHESANT) 1494911 0.18 0.0004 0.0828 0.514
0.489-0.539
1.9
OR 95% CI: 0.97-3.71
Binary weak
172.1 Melanomas of skin, dx or hx
ICD-10 D03 Melanoma in situ
MGI lassosum UKB GWAS (ICD10) 3838429 0.18 0.002 0.0969 0.512
0.496-0.528
1.54
OR 95% CI: 0.96-2.46
Binary weak
184.11 Malignant neoplasm of ovary
ICD-10 C56 Malignant neoplasm of ovary
MGI P&T UKB GWAS (ICD10) 14 0.18 0.0016 0.0828 0.519
0.475-0.563
1.91
OR 95% CI: 0.587-6.22
Binary weak
202.21 Nodular lymphoma
ICD-10 C82 Follicular [nodular] non-Hodgkin's lymphoma
MGI Fixed threshold (5e-07) UKB GWAS (ICD10) 10 0.18 0.0001 0.0826 0.479
0.447-0.511
1.14
OR 95% CI: 0.371-3.53
Binary weak
204.1 Lymphoid leukemia
ICD-10 C91 Lymphoid leukaemia
MGI P&T UKB GWAS (ICD10) 6 0.18 0.001 0.0825 0.512
0.448-0.573
1.57
OR 95% CI: 0.256-9.68
Binary weak
149.4 Cancer of larynx
ICD-10 C32 Malignant neoplasm of larynx
MGI PRS-CS UKB GWAS (ICD10) 967720 0.19 0.0006 0.0826 0.532
0.487-0.58
0.905
OR 95% CI: 0.162-5.05
Binary weak
153.3 Malignant neoplasm of rectum, rectosigmoid junction, and anus
ICD-10 C21 Malignant neoplasm of anus and anal canal
MGI PRS-CS UKB GWAS (ICD10) 923679 0.19 0.0001 0.0829 0.528
0.493-0.564
1.65
OR 95% CI: 0.658-4.13
Binary weak
165 Cancer within the respiratory system
Malignant neoplasm of respiratory system and intrathoracic organs
MGI PRS-CS UKB GWAS (FINNGEN) 1110227 0.19 0.0002 0.0827 0.52
0.493-0.547
1.78
OR 95% CI: 0.848-3.73
Binary weak
189.11 Malignant neoplasm of kidney, except pelvis
Self-reported kidney/renal cell cancer
MGI PRS-CS UKB GWAS (PHESANT) 1067434 0.19 0.001 0.0827 0.513
0.487-0.542
1.58
OR 95% CI: 0.757-3.28
Binary weak
202 Cancer of other lymphoid, histiocytic tissue
Lymphomas
MGI P&T UKB GWAS (FINNGEN) 14 0.19 0.0017 0.0827 0.496
0.474-0.52
0.982
OR 95% CI: 0.435-2.22
Binary weak
202.2 Non-Hodgkin lymphoma
ICD-10 C83 Diffuse non-Hodgkin's lymphoma
MGI Fixed threshold (5e-05) UKB GWAS (ICD10) 119 0.19 0.002 0.0827 0.513
0.488-0.539
1.26
OR 95% CI: 0.584-2.72
Binary weak
202.21 Nodular lymphoma
MGI Fixed threshold (5e-06) UKB GWAS (PheCode) 24 0.19 0.0007 0.0826 0.492
0.459-0.524
1.15
OR 95% CI: 0.374-3.56
Binary weak
150 Cancer of esophagus
Self-reported oesophageal cancer
MGI P&T UKB GWAS (PHESANT) 24 0.2 0.0059 0.0827 0.519
0.479-0.559
1.78
OR 95% CI: 0.551-5.73
Binary weak
170.1 Bone cancer
Cancer code, self-reported: primary bone cancer (UKB GWAS (PHESANT))
MGI PRS-CS UKB GWAS (PheCode) 1119238 0.2 0.0007 0.0829 0.52
0.488-0.553
1.58
OR 95% CI: 0.633-3.95
Binary weak
180.3 Cervical intraepithelial neoplasia [CIN] [Cervical dysplasia]
Self-reported cin/pre-cancer cells cervix
MGI PRS-CS UKB GWAS (PHESANT) 1105412 0.2 0.0039 0.0885 0.525
0.498-0.553
0.536
OR 95% CI: 0.147-1.95
Binary weak
189.11 Malignant neoplasm of kidney, except pelvis
Renal cell carcinoma;Wilms tumor
MGI Fixed threshold (5e-09) GWAS Catalog (2019-05-03) 8 0.2 0.0004 0.0827 0.489
0.464-0.514
1.57
OR 95% CI: 0.752-3.27
Binary weak
202.2 Non-Hodgkin lymphoma
ICD-10 C83 Diffuse non-Hodgkin's lymphoma
MGI P&T UKB GWAS (ICD10) 134 0.2 0.0026 0.0827 0.512
0.487-0.539
1.09
OR 95% CI: 0.482-2.48
Binary weak
159.4 Malignant neoplasm of retroperitoneum and peritoneum
ICD-10 C48 Malignant neoplasm of retroperitoneum and peritoneum
MGI lassosum UKB GWAS (ICD10) 276551 0.21 0.0028 0.0825 0.532
0.479-0.587
1.09
OR 95% CI: 0.19-6.3
Binary weak
165 Cancer within the respiratory system
MGI P&T UKB GWAS (PheCode) 46 0.21 0.0002 0.0827 0.508
0.482-0.537
1.34
OR 95% CI: 0.584-3.08
Binary weak
165.1 Cancer of bronchus; lung
Self-reported lung cancer
MGI P&T UKB GWAS (PHESANT) 71 0.21 0.0003 0.0827 0.516
0.486-0.544
1
OR 95% CI: 0.374-2.68
Binary weak
170.2 Cancer of connective tissue
Self-reported sarcoma/fibrosarcoma
MGI PRS-CS UKB GWAS (PHESANT) 971543 0.21 0.0001 0.0828 0.517
0.493-0.542
1.53
OR 95% CI: 0.736-3.19
Binary weak
182 Malignant neoplasm of uterus
ICD-10 C54 Malignant neoplasm of corpus uteri
MGI Fixed threshold (5e-05) UKB GWAS (ICD10) 123 0.21 0.0001 0.0832 0.514
0.485-0.547
0.739
OR 95% CI: 0.2-2.72
Binary weak
201 Hodgkin's disease
Self-reported hodgkins lymphoma / hodgkins disease
MGI P&T UKB GWAS (PHESANT) 65 0.21 0.0196 0.083 0.533
0.461-0.608
2.79
OR 95% CI: 0.62-12.6
Binary weak
204.4 Multiple myeloma
ICD-10 C90 Multiple myeloma and malignant plasma cell neoplasms
MGI Fixed threshold (5e-05) UKB GWAS (ICD10) 107 0.21 0.0001 0.0826 0.535
0.475-0.598
2.69
OR 95% CI: 0.615-11.7
Binary weak
149 Cancer of larynx, pharynx, nasal cavities
MGI lassosum UKB GWAS (PheCode) 1881193 0.22 0.0009 0.0828 0.519
0.495-0.544
0.8
OR 95% CI: 0.303-2.11
Binary weak
149.4 Cancer of larynx
Malignant neoplasm of larynx
MGI Fixed threshold (5e-06) UKB GWAS (FINNGEN) 15 0.22 0.0032 0.0826 0.517
0.468-0.567
2.16
OR 95% CI: 0.656-7.12
Binary weak
170.1 Bone cancer
Self-reported primary bone cancer
MGI Fixed threshold (5e-06) UKB GWAS (PHESANT) 5 0.22 0.0004 0.0829 0.504
0.471-0.538
1
OR 95% CI: 0.328-3.06
Binary weak
184.11 Malignant neoplasm of ovary
Self-reported ovarian cancer
MGI P&T UKB GWAS (PHESANT) 34 0.22 0.0037 0.0829 0.518
0.473-0.562
1.3
OR 95% CI: 0.334-5.07
Binary weak
184.11 Malignant neoplasm of ovary
Self-reported ovarian cancer
MGI PRS-CS UKB GWAS (PHESANT) 1082696 0.22 0.0004 0.0829 0.529
0.483-0.57
0.737
OR 95% CI: 0.133-4.07
Binary weak
189.11 Malignant neoplasm of kidney, except pelvis
Renal cell carcinoma;Wilms tumor (GWAS Catalog (2019-05-03))
MGI PRS-CS UKB GWAS (PheCode) 1119238 0.22 0 0.0827 0.515
0.489-0.536
1.18
OR 95% CI: 0.518-2.69
Binary weak
191.1 Cancer of brain and nervous system
Malignant neoplasm of eye, brain and central nervous system
MGI PRS-CS UKB GWAS (FINNGEN) 1072894 0.22 0.0008 0.0826 0.526
0.49-0.562
0.876
OR 95% CI: 0.235-3.27
Binary weak
204.12 Lymphoid leukemia, chronic
Self-reported chronic lymphocytic
MGI P&T UKB GWAS (PHESANT) 7 0.22 0.0015 0.0828 0.522
0.452-0.593
1.93
OR 95% CI: 0.295-12.6
Binary weak
153.3 Malignant neoplasm of rectum, rectosigmoid junction, and anus
Malignant neoplasm of rectosigmoid junction
MGI lassosum UKB GWAS (FINNGEN) 592740 0.23 0.001 0.0829 0.526
0.496-0.561
1.01
OR 95% CI: 0.331-3.1
Binary weak
159.2 Malignant neoplasm of small intestine, including duodenum
Malignant neoplasm of small intestine
MGI P&T UKB GWAS (FINNGEN) 25 0.23 0.0024 0.0825 0.534
0.468-0.602
1.73
OR 95% CI: 0.277-10.8
Binary weak
184.11 Malignant neoplasm of ovary
Mucinous ovarian carcinoma
MGI Fixed threshold (5e-06) Phelan CM et al. 2017 27 0.23 0.002 0.0829 0.525
0.484-0.57
1.36
OR 95% CI: 0.349-5.28
Binary weak
189 Cancer of urinary organs (incl. kidney and bladder)
Malignant neoplasm of urinary organs
MGI P&T UKB GWAS (FINNGEN) 77 0.23 0.0003 0.0975 0.5
0.483-0.518
0.992
OR 95% CI: 0.558-1.77
Binary weak
189.11 Malignant neoplasm of kidney, except pelvis
Renal cell carcinoma;Wilms tumor (GWAS Catalog (2019-05-03))
MGI Fixed threshold (5e-06) UKB GWAS (PheCode) 13 0.23 0.0009 0.0827 0.489
0.463-0.513
1.01
OR 95% CI: 0.417-2.46
Binary weak
194 Cancer of other endocrine glands
Malignant neoplasm of endocrine gland
MGI PRS-CS UKB GWAS (FINNGEN) 1061061 0.23 0.0016 0.0827 0.538
0.484-0.586
0
OR 95% CI: 0-0
Binary weak
204 Leukemia
MGI P&T UKB GWAS (PheCode) 11 0.23 0.0016 0.0826 0.515
0.483-0.549
0
OR 95% CI: 0-0
Binary weak
145 Cancer of mouth
MGI lassosum UKB GWAS (PheCode) 816404 0.24 0.0022 0.0829 0.51
0.485-0.535
1.11
OR 95% CI: 0.487-2.51
Binary weak
145.2 Cancer of tongue
Malignant neoplasm of other and unspecified parts of tongue (UKB GWAS (FINNGEN))
MGI Fixed threshold (5e-06) UKB GWAS (PheCode) 8 0.24 0.0002 0.0828 0.48
0.443-0.516
2.1
OR 95% CI: 0.82-5.39
Binary weak
149 Cancer of larynx, pharynx, nasal cavities
MGI Fixed threshold (5e-05) UKB GWAS (PheCode) 84 0.24 0 0.0828 0.509
0.483-0.535
1.16
OR 95% CI: 0.511-2.64
Binary weak
150 Cancer of esophagus
Malignant neoplasm of oesophagus
MGI lassosum UKB GWAS (FINNGEN) 91277 0.24 0.0065 0.0827 0.531
0.494-0.57
0
OR 95% CI: 0-0
Binary weak
159 Malignant neoplasm of other and ill-defined sites within the digestive organs and peritoneum
Malignant neoplasm of digestive organs
MGI Fixed threshold (5e-06) UKB GWAS (FINNGEN) 29 0.24 0.0001 0.0826 0.505
0.476-0.533
1.94
OR 95% CI: 0.875-4.29
Binary weak
182 Malignant neoplasm of uterus
Endometrial cancer;Endometrial cancer (endometrioid histology);Endometrial endometrioid carcinoma;Endometrial cancer (Non-endometrioid histology) (GWAS Catalog (2019-05-03))
MGI PRS-CS UKB GWAS (PheCode) 1119236 0.24 0.0014 0.0832 0.514
0.48-0.547
1.32
OR 95% CI: 0.484-3.59
Binary weak
189.2 Cancer of bladder
ICD-10 C67 Malignant neoplasm of bladder
MGI Fixed threshold (5e-05) UKB GWAS (ICD10) 147 0.24 0 0.0922 0.504
0.483-0.525
1.03
OR 95% CI: 0.499-2.11
Binary weak
193 Thyroid cancer
Malignant neoplasm of thyroid gland
MGI PRS-CS UKB GWAS (FINNGEN) 1054932 0.24 0.0005 0.0828 0.52
0.49-0.549
1.65
OR 95% CI: 0.708-3.83
Binary weak
202 Cancer of other lymphoid, histiocytic tissue
Mature T/NK-cell lymphomas
MGI Fixed threshold (5e-05) UKB GWAS (FINNGEN) 50 0.24 0.0004 0.0827 0.512
0.487-0.535
1.14
OR 95% CI: 0.53-2.44
Binary weak
202 Cancer of other lymphoid, histiocytic tissue
Marginal zone lymphoma;Waldenström macroglobulinemia / lymphoplasmacytic lymphoma (GWAS Catalog (2019-05-03))
MGI Fixed threshold (5e-06) UKB GWAS (PheCode) 17 0.24 0.0001 0.0827 0.51
0.486-0.533
0.982
OR 95% CI: 0.435-2.22
Binary weak
202.21 Nodular lymphoma
MGI GWAS Hits UKB GWAS (PheCode) 8 0.24 0.0004 0.0826 0.474
0.442-0.506
1.81
OR 95% CI: 0.715-4.57
Binary weak
204.11 Lymphoid leukemia, acute
Acute lymphoblastic leukemia (childhood);Acute lymphoblastic leukemia (B-cell precursor);Acute lymphoblastic leukemia in childhood (B cell precursor)
MGI GWAS Hits GWAS Catalog (2019-05-03) 7 0.24 0.0022 0.0824 0.558
0.451-0.662
3.64
OR 95% CI: 0.441-30.1
Binary weak
204.4 Multiple myeloma
and malignant plasma cell neoplasms
MGI P&T UKB GWAS (FINNGEN) 32 0.24 0.0019 0.0826 0.523
0.461-0.587
0
OR 95% CI: 0-0
Binary weak
151 Cancer of stomach
Cancer code, self-reported: stomach cancer (UKB GWAS (PHESANT))
MGI Fixed threshold (5e-05) UKB GWAS (PheCode) 76 0.25 0 0.0828 0.519
0.477-0.56
0.655
OR 95% CI: 0.121-3.53
Binary weak
159.3 Malignant neoplasm of gallbladder and extrahepatic bile ducts
MGI Fixed threshold (5e-05) UKB GWAS (PheCode) 84 0.25 0.0192 0.0824 0.526
0.454-0.601
2.88
OR 95% CI: 0.632-13.2
Binary weak
165.1 Cancer of bronchus; lung
Self-reported lung cancer
MGI Fixed threshold (5e-05) UKB GWAS (PHESANT) 52 0.25 0.0001 0.0827 0.514
0.486-0.542
1.01
OR 95% CI: 0.376-2.7
Binary weak
172.3 Carcinoma in situ of skin
ICD-10 D04 Carcinoma in situ of skin
MGI Fixed threshold (5e-06) UKB GWAS (ICD10) 12 0.25 0.0006 0.094 0.499
0.474-0.524
1.46
OR 95% CI: 0.693-3.07
Binary weak
202.2 Non-Hodgkin lymphoma
Diffuse large B cell lymphoma;Follicular lymphoma
MGI P&T GWAS Catalog (2019-05-03) 10 0.25 0.0074 0.0827 0.505
0.483-0.528
1.41
OR 95% CI: 0.68-2.92
Binary weak
202.21 Nodular lymphoma
MGI Fixed threshold (5e-07) UKB GWAS (PheCode) 10 0.25 0.0006 0.0826 0.478
0.446-0.51
1.81
OR 95% CI: 0.715-4.57
Binary weak
149 Cancer of larynx, pharynx, nasal cavities
MGI P&T UKB GWAS (PheCode) 24 0.26 0.0003 0.0828 0.501
0.476-0.526
1.68
OR 95% CI: 0.835-3.37
Binary weak
150 Cancer of esophagus
Malignant neoplasm of oesophagus
MGI Fixed threshold (5e-05) UKB GWAS (FINNGEN) 96 0.26 0 0.0827 0.529
0.483-0.568
1.28
OR 95% CI: 0.331-4.96
Binary weak
151 Cancer of stomach
Cancer code, self-reported: stomach cancer (UKB GWAS (PHESANT))
MGI lassosum UKB GWAS (PheCode) 1242 0.26 0.0025 0.0828 0.525
0.483-0.561
2.01
OR 95% CI: 0.71-5.68
Binary weak
157 Pancreatic cancer
GWAS Catalog (2019-05-03)
MGI PRS-CS UKB GWAS (PheCode) 1119238 0.26 0.0003 0.0828 0.524
0.482-0.564
1.98
OR 95% CI: 0.701-5.62
Binary weak
184.11 Malignant neoplasm of ovary
Low-grade serous ovarian cancer
UKB PRS-CS Phelan CM et al. 2017 1115179 0.26 0.0017 0.0827 0.504
0.477-0.533
1.97
OR 95% CI: 0.971-4
Binary weak
184.11 Malignant neoplasm of ovary
Mucinous ovarian carcinoma
UKB PRS-CS Phelan CM et al. 2017 1115189 0.26 0.0008 0.0827 0.509
0.483-0.536
2.4
OR 95% CI: 1.25-4.63
Binary weak
189 Cancer of urinary organs (incl. kidney and bladder)
Malignant neoplasm of urinary organs
MGI Fixed threshold (5e-05) UKB GWAS (FINNGEN) 122 0.26 0.0001 0.0975 0.502
0.485-0.519
1.23
OR 95% CI: 0.712-2.11
Binary weak
201 Hodgkin's disease
Self-reported hodgkins lymphoma / hodgkins disease
MGI Fixed threshold (5e-05) UKB GWAS (PHESANT) 82 0.26 0.0106 0.083 0.528
0.456-0.601
4.08
OR 95% CI: 1.07-15.5
Binary weak
145 Cancer of mouth
MGI P&T UKB GWAS (PheCode) 21 0.27 0.0008 0.0829 0.506
0.483-0.529
0.774
OR 95% CI: 0.294-2.04
Binary weak
145.2 Cancer of tongue
Self-reported tongue cancer
MGI lassosum UKB GWAS (PHESANT) 1826297 0.27 0.0031 0.0828 0.514
0.479-0.55
0.562
OR 95% CI: 0.105-3
Binary weak
180.3 Cervical intraepithelial neoplasia [CIN] [Cervical dysplasia]
Self-reported cin/pre-cancer cells cervix
MGI Fixed threshold (5e-06) UKB GWAS (PHESANT) 28 0.27 0.0002 0.0885 0.503
0.475-0.533
0.739
OR 95% CI: 0.244-2.24
Binary weak
182 Malignant neoplasm of uterus
ICD-10 C54 Malignant neoplasm of corpus uteri
MGI PRS-CS UKB GWAS (ICD10) 1101394 0.27 0.0004 0.0832 0.516
0.482-0.543
0.727
OR 95% CI: 0.197-2.68
Binary weak
184.11 Malignant neoplasm of ovary
Epithelial ovarian cancer;High-grade serous ovarian cancer;Serous invasive ovarian cancer;Invasive epithelial ovarian cancer;Mucinous ovarian carcinoma;Low-grade serous and serous borderline ovarian cancer;Serous borderline ovarian cancer;Ovarian cancer in BRCA1 mutation carriers;Ovarian cancer;Ovarian clear cell cancer
MGI Fixed threshold (5e-09) GWAS Catalog (2019-05-03) 14 0.27 0.0042 0.0829 0.526
0.481-0.571
0.803
OR 95% CI: 0.145-4.43
Binary weak
184.11 Malignant neoplasm of ovary
Mucinous ovarian carcinoma
MGI GWAS Hits Phelan CM et al. 2017 5 0.27 0.0007 0.0829 0.522
0.474-0.567
2.46
OR 95% CI: 0.848-7.13
Binary weak
187.2 Malignant neoplasm of testis
Diagnoses - main ICD10: C62 Malignant neoplasm of testis (UKB GWAS (ICD10))
MGI Fixed threshold (5e-05) UKB GWAS (PheCode) 155 0.27 0.0001 0.086 0.552
0.48-0.618
0
OR 95% CI: 0-0
Binary weak
189.11 Malignant neoplasm of kidney, except pelvis
Self-reported kidney/renal cell cancer
MGI P&T UKB GWAS (PHESANT) 17 0.27 0.0003 0.0827 0.496
0.471-0.523
1.74
OR 95% CI: 0.863-3.5
Binary weak
204.4 Multiple myeloma
Multiple myeloma (hyperdiploidy);Multiple myeloma (IgH translocation);Multiple myeloma;Multiple myeloma and monoclonal gammopathy (GWAS Catalog (2019-05-03))
MGI lassosum UKB GWAS (PheCode) 614225 0.27 0.0048 0.0826 0.539
0.473-0.603
1.52
OR 95% CI: 0.247-9.42
Binary weak
150 Cancer of esophagus
Self-reported oesophageal cancer
MGI lassosum UKB GWAS (PHESANT) 406747 0.28 0.0038 0.0827 0.519
0.478-0.563
1.79
OR 95% CI: 0.557-5.78
Binary weak
153.3 Malignant neoplasm of rectum, rectosigmoid junction, and anus
ICD-10 C20 Malignant neoplasm of rectum
MGI lassosum UKB GWAS (ICD10) 4790230 0.28 0.0016 0.083 0.524
0.493-0.557
0
OR 95% CI: 0-0
Binary weak
184.11 Malignant neoplasm of ovary
Self-reported ovarian cancer
MGI Fixed threshold (5e-06) UKB GWAS (PHESANT) 18 0.28 0.0017 0.0829 0.503
0.46-0.549
2.36
OR 95% CI: 0.812-6.85
Binary weak
184.11 Malignant neoplasm of ovary
Invasive epithelial ovarian cancer
MGI P&T Phelan CM et al. 2017 144 0.28 0.0015 0.0829 0.535
0.495-0.577
0
OR 95% CI: 0-0
Binary weak
184.11 Malignant neoplasm of ovary
Serous invasive ovarian cancer
MGI P&T Phelan CM et al. 2017 104 0.28 0.0068 0.0829 0.528
0.486-0.569
0.783
OR 95% CI: 0.142-4.32
Binary weak
189.11 Malignant neoplasm of kidney, except pelvis
Malignant neoplasm of kidney, except renal pelvis
MGI Fixed threshold (5e-05) UKB GWAS (FINNGEN) 132 0.28 0 0.0827 0.511
0.485-0.536
1.03
OR 95% CI: 0.425-2.51
Binary weak
189.2 Cancer of bladder
Self-reported bladder cancer
MGI Fixed threshold (5e-05) UKB GWAS (PHESANT) 131 0.28 0.002 0.0923 0.51
0.491-0.529
0.799
OR 95% CI: 0.354-1.8
Binary weak
190 Cancer of eye
ICD-10 C69 Malignant neoplasm of eye and adnexa
MGI lassosum UKB GWAS (ICD10) 1496730 0.28 0.013 0.0836 0.54
0.461-0.621
1.82
OR 95% CI: 0.268-12.4
Binary weak
191.1 Cancer of brain and nervous system
Glioma;Non-glioblastoma glioma;Glioma (high-grade)
MGI GWAS Hits GWAS Catalog (2019-05-03) 23 0.28 0.0058 0.0826 0.511
0.476-0.546
0.872
OR 95% CI: 0.234-3.25
Binary weak
191.1 Cancer of brain and nervous system
Glioma;Non-glioblastoma glioma;Glioma (high-grade) (GWAS Catalog (2019-05-03))
MGI lassosum UKB GWAS (PheCode) 43 0.28 0.008 0.0826 0.506
0.47-0.538
1.23
OR 95% CI: 0.396-3.8
Binary weak
202.21 Nodular lymphoma
ICD-10 C82 Follicular [nodular] non-Hodgkin's lymphoma
MGI P&T UKB GWAS (ICD10) 5 0.28 0.0004 0.0826 0.467
0.436-0.501
1.8
OR 95% CI: 0.712-4.55
Binary weak
204.4 Multiple myeloma
(hyperdiploidy);Multiple myeloma (IgH translocation);Multiple myeloma;Multiple myeloma and monoclonal gammopathy
MGI Fixed threshold (5e-07) GWAS Catalog (2019-05-03) 28 0.28 0.0135 0.0826 0.519
0.453-0.583
3.79
OR 95% CI: 1.01-14.2
Binary weak
159 Malignant neoplasm of other and ill-defined sites within the digestive organs and peritoneum
Malignant neoplasm of digestive organs
MGI P&T UKB GWAS (FINNGEN) 18 0.29 0.0009 0.0826 0.497
0.466-0.526
2.44
OR 95% CI: 1.18-5.03
Binary weak
180.1 Cervical cancer
Self-reported cervical cancer
MGI Fixed threshold (5e-06) UKB GWAS (PHESANT) 17 0.29 0.0019 0.0826 0.511
0.471-0.549
1.51
OR 95% CI: 0.479-4.78
Binary weak
180.1 Cervical cancer
Malignant neoplasm of cervix uteri
MGI P&T UKB GWAS (FINNGEN) 105 0.29 0.0026 0.0826 0.519
0.477-0.56
0.622
OR 95% CI: 0.116-3.34
Binary weak
187.2 Malignant neoplasm of testis
Self-reported testicular cancer
MGI PRS-CS UKB GWAS (PHESANT) 1084569 0.29 0.0077 0.0859 0.539
0.462-0.614
0
OR 95% CI: 0-0
Binary weak
190 Cancer of eye
Malignant neoplasm of eye and adnexa
MGI PRS-CS UKB GWAS (FINNGEN) 849853 0.3 0.0001 0.0836 0.546
0.47-0.622
1.99
OR 95% CI: 0.308-12.8
Binary weak
191.1 Cancer of brain and nervous system
Glioma;Non-glioblastoma glioma;Glioma (high-grade)
MGI Fixed threshold (5e-07) GWAS Catalog (2019-05-03) 25 0.3 0.0071 0.0826 0.51
0.474-0.544
1.23
OR 95% CI: 0.397-3.81
Binary weak
201 Hodgkin's disease
ICD-10 C81 Hodgkin's disease
MGI PRS-CS UKB GWAS (ICD10) 945902 0.3 0.0008 0.083 0.528
0.451-0.603
4.03
OR 95% CI: 1.07-15.2
Binary weak
201 Hodgkin's disease
Self-reported hodgkins lymphoma / hodgkins disease
MGI lassosum UKB GWAS (PHESANT) 304734 0.3 0.0165 0.083 0.55
0.475-0.617
2.94
OR 95% CI: 0.645-13.4
Binary weak
202 Cancer of other lymphoid, histiocytic tissue
Lymphomas
MGI Fixed threshold (5e-07) UKB GWAS (FINNGEN) 8 0.3 0.001 0.0827 0.493
0.47-0.515
1.14
OR 95% CI: 0.532-2.45
Binary weak
145.2 Cancer of tongue
ICD-10 C01 Malignant neoplasm of base of tongue
MGI PRS-CS UKB GWAS (ICD10) 854886 0.31 0.0002 0.0828 0.523
0.488-0.558
0.922
OR 95% CI: 0.246-3.46
Binary weak
157 Pancreatic cancer
ICD-10 C25 Malignant neoplasm of pancreas
MGI lassosum UKB GWAS (ICD10) 2230 0.31 0.0042 0.0828 0.517
0.476-0.556
1.96
OR 95% CI: 0.691-5.55
Binary weak
159.2 Malignant neoplasm of small intestine, including duodenum
Self-reported small intestine/small bowel cancer
MGI Fixed threshold (5e-06) UKB GWAS (PHESANT) 11 0.31 0.0079 0.0825 0.518
0.445-0.597
5.41
OR 95% CI: 1.6-18.3
Binary weak
159.2 Malignant neoplasm of small intestine, including duodenum
Self-reported small intestine/small bowel cancer
MGI P&T UKB GWAS (PHESANT) 11 0.31 0.0079 0.0825 0.518
0.445-0.597
5.41
OR 95% CI: 1.6-18.3
Binary weak
184.11 Malignant neoplasm of ovary
High-grade serous ovarian cancer
MGI Fixed threshold (5e-05) Phelan CM et al. 2017 116 0.31 0.0008 0.0829 0.513
0.473-0.557
1.86
OR 95% CI: 0.571-6.04
Binary weak
184.11 Malignant neoplasm of ovary
Ovarian clear cell cancer
MGI Fixed threshold (5e-06) Phelan CM et al. 2017 12 0.31 0.0005 0.0829 0.528
0.482-0.573
3.59
OR 95% CI: 1.42-9.08
Binary weak
184.11 Malignant neoplasm of ovary
Low-grade serous and serous borderline ovarian cancer
MGI P&T Phelan CM et al. 2017 34 0.31 0.0095 0.0829 0.527
0.485-0.569
0
OR 95% CI: 0-0
Binary weak
204.1 Lymphoid leukemia
ICD-10 C91 Lymphoid leukaemia
MGI Fixed threshold (5e-06) UKB GWAS (ICD10) 21 0.31 0.0001 0.0825 0.521
0.453-0.588
1.51
OR 95% CI: 0.247-9.27
Binary weak
204.12 Lymphoid leukemia, chronic
Chronic lymphocytic leukemia (GWAS Catalog (2019-05-03))
MGI Fixed threshold (5e-06) UKB GWAS (PheCode) 24 0.31 0.0002 0.0828 0.521
0.447-0.598
1.96
OR 95% CI: 0.299-12.8
Binary weak
204.4 Multiple myeloma
(hyperdiploidy);Multiple myeloma (IgH translocation);Multiple myeloma;Multiple myeloma and monoclonal gammopathy
MGI Fixed threshold (5e-09) GWAS Catalog (2019-05-03) 15 0.31 0.006 0.0826 0.524
0.46-0.584
3.7
OR 95% CI: 1-13.6
Binary weak
165 Cancer within the respiratory system
MGI Fixed threshold (5e-05) UKB GWAS (PheCode) 103 0.32 0 0.0827 0.505
0.479-0.532
1.74
OR 95% CI: 0.83-3.65
Binary weak
202.21 Nodular lymphoma
ICD-10 C82 Follicular [nodular] non-Hodgkin's lymphoma
MGI Fixed threshold (5e-06) UKB GWAS (ICD10) 17 0.32 0.0001 0.0826 0.484
0.453-0.516
0.816
OR 95% CI: 0.22-3.02
Binary weak
145 Cancer of mouth
Malignant neoplasm of lip, oral cavity and pharynx
MGI Fixed threshold (5e-05) UKB GWAS (FINNGEN) 105 0.33 0.0005 0.0829 0.499
0.477-0.524
2.13
OR 95% CI: 1.14-3.97
Binary weak
180.1 Cervical cancer
ICD-10 D06 Carcinoma in situ of cervix uteri
MGI PRS-CS UKB GWAS (ICD10) 1067182 0.33 0.0008 0.0826 0.521
0.479-0.564
1.07
OR 95% CI: 0.282-4.08
Binary weak
189.11 Malignant neoplasm of kidney, except pelvis
ICD-10 C64 Malignant neoplasm of kidney, except renal pelvis
MGI PRS-CS UKB GWAS (ICD10) 1092593 0.33 0.0001 0.0827 0.514
0.489-0.538
1.58
OR 95% CI: 0.76-3.3
Binary weak
202 Cancer of other lymphoid, histiocytic tissue
Non-follicular lymphoma
MGI lassosum UKB GWAS (FINNGEN) 238 0.33 0.0009 0.0827 0.495
0.472-0.519
0.989
OR 95% CI: 0.438-2.23
Binary weak
202.2 Non-Hodgkin lymphoma
ICD-10 C83 Diffuse non-Hodgkin's lymphoma
MGI Fixed threshold (5e-06) UKB GWAS (ICD10) 18 0.33 0.0005 0.0827 0.496
0.473-0.521
1.26
OR 95% CI: 0.585-2.73
Binary weak
153.3 Malignant neoplasm of rectum, rectosigmoid junction, and anus
ICD-10 C21 Malignant neoplasm of anus and anal canal
MGI P&T UKB GWAS (ICD10) 46 0.34 0.0038 0.083 0.512
0.477-0.547
1.34
OR 95% CI: 0.493-3.65
Binary weak
153.3 Malignant neoplasm of rectum, rectosigmoid junction, and anus
ICD-10 C20 Malignant neoplasm of rectum
MGI PRS-CS UKB GWAS (ICD10) 1104940 0.34 0.0001 0.083 0.521
0.488-0.553
0
OR 95% CI: 0-0
Binary weak
159.2 Malignant neoplasm of small intestine, including duodenum
MGI Fixed threshold (5e-06) UKB GWAS (PheCode) 10 0.34 0.0002 0.0826 0.512
0.45-0.579
0
OR 95% CI: 0-0
Binary weak
165 Cancer within the respiratory system
MGI Fixed threshold (5e-06) UKB GWAS (PheCode) 18 0.34 0 0.0827 0.503
0.477-0.532
1.12
OR 95% CI: 0.46-2.75
Binary weak
165.1 Cancer of bronchus; lung
ICD-10 C34 Malignant neoplasm of bronchus and lung
MGI Fixed threshold (5e-07) UKB GWAS (ICD10) 6 0.34 0.0011 0.0828 0.486
0.46-0.513
1.02
OR 95% CI: 0.38-2.72
Binary weak
191.1 Cancer of brain and nervous system
Glioma;Non-glioblastoma glioma;Glioma (high-grade)
MGI Fixed threshold (5e-05) GWAS Catalog (2019-05-03) 28 0.34 0.0073 0.0826 0.51
0.474-0.545
0.875
OR 95% CI: 0.235-3.26
Binary weak
191.1 Cancer of brain and nervous system
Glioma;Non-glioblastoma glioma;Glioma (high-grade)
MGI Fixed threshold (5e-06) GWAS Catalog (2019-05-03) 28 0.34 0.0073 0.0826 0.51
0.474-0.545
0.875
OR 95% CI: 0.235-3.26
Binary weak
191.1 Cancer of brain and nervous system
Glioma;Non-glioblastoma glioma;Glioma (high-grade)
MGI P&T GWAS Catalog (2019-05-03) 28 0.34 0.0073 0.0826 0.51
0.474-0.545
0.875
OR 95% CI: 0.235-3.26
Binary weak
202.2 Non-Hodgkin lymphoma
Diffuse large B cell lymphoma;Follicular lymphoma
MGI Fixed threshold (5e-05) GWAS Catalog (2019-05-03) 18 0.34 0.0057 0.0827 0.504
0.48-0.527
1.58
OR 95% CI: 0.787-3.16
Binary weak
155.1 Malignant neoplasm of liver, primary
MGI P&T UKB GWAS (PheCode) 5 0.35 0.0022 0.0825 0.473
0.427-0.52
2.99
OR 95% CI: 0.99-9.04
Binary weak
165 Cancer within the respiratory system
ICD-10 C45 Mesothelioma
MGI PRS-CS UKB GWAS (ICD10) 934591 0.35 0.0012 0.0827 0.511
0.485-0.54
1.56
OR 95% CI: 0.713-3.4
Binary weak
165.1 Cancer of bronchus; lung
ICD-10 C34 Malignant neoplasm of bronchus and lung
MGI lassosum UKB GWAS (ICD10) 35698 0.35 0.0021 0.0828 0.51
0.481-0.538
0.808
OR 95% CI: 0.268-2.44
Binary weak
170.1 Bone cancer
Self-reported primary bone cancer
MGI P&T UKB GWAS (PHESANT) 7 0.35 0.0022 0.0829 0.508
0.478-0.54
1.01
OR 95% CI: 0.33-3.08
Binary weak
180.1 Cervical cancer
Self-reported cervical cancer
MGI Fixed threshold (5e-05) UKB GWAS (PHESANT) 127 0.35 0 0.0826 0.511
0.468-0.553
2.42
OR 95% CI: 0.933-6.3
Binary weak
180.3 Cervical intraepithelial neoplasia [CIN] [Cervical dysplasia]
Self-reported cin/pre-cancer cells cervix
MGI P&T UKB GWAS (PHESANT) 10 0.35 0.0008 0.0885 0.493
0.465-0.522
1.73
OR 95% CI: 0.784-3.84
Binary weak
184.11 Malignant neoplasm of ovary
High-grade serous ovarian cancer
UKB lassosum Phelan CM et al. 2017 37433 0.35 0.0018 0.0827 0.514
0.487-0.54
0.923
OR 95% CI: 0.347-2.45
Binary weak
190 Cancer of eye
ICD-10 C69 Malignant neoplasm of eye and adnexa
MGI Fixed threshold (5e-05) UKB GWAS (ICD10) 35 0.35 0.003 0.0837 0.534
0.464-0.611
0
OR 95% CI: 0-0
Binary weak
202 Cancer of other lymphoid, histiocytic tissue
Mature T/NK-cell lymphomas
MGI Fixed threshold (5e-06) UKB GWAS (FINNGEN) 10 0.35 0 0.0827 0.502
0.479-0.526
1.31
OR 95% CI: 0.636-2.7
Binary weak
145.2 Cancer of tongue
ICD-10 C01 Malignant neoplasm of base of tongue
MGI lassosum UKB GWAS (ICD10) 1312025 0.36 0.0012 0.0828 0.52
0.484-0.554
0.939
OR 95% CI: 0.251-3.51
Binary weak
151 Cancer of stomach
Self-reported stomach cancer
MGI lassosum UKB GWAS (PHESANT) 63785 0.36 0.0024 0.0829 0.518
0.477-0.56
2.47
OR 95% CI: 0.945-6.46
Binary weak
153.3 Malignant neoplasm of rectum, rectosigmoid junction, and anus
Malignant neoplasm of rectum
MGI Fixed threshold (5e-06) UKB GWAS (FINNGEN) 19 0.36 0 0.083 0.493
0.462-0.526
1.65
OR 95% CI: 0.66-4.15
Binary weak
153.3 Malignant neoplasm of rectum, rectosigmoid junction, and anus
ICD-10 C21 Malignant neoplasm of anus and anal canal
MGI lassosum UKB GWAS (ICD10) 67145 0.36 0.0022 0.083 0.521
0.488-0.555
1.06
OR 95% CI: 0.345-3.25
Binary weak
180.1 Cervical cancer
ICD-10 D06 Carcinoma in situ of cervix uteri
MGI Fixed threshold (5e-05) UKB GWAS (ICD10) 93 0.36 0.0002 0.0826 0.515
0.477-0.551
1.51
OR 95% CI: 0.478-4.77
Binary weak
184.11 Malignant neoplasm of ovary
Self-reported ovarian cancer
MGI Fixed threshold (5e-05) UKB GWAS (PHESANT) 100 0.36 0.0019 0.0829 0.514
0.466-0.558
2.36
OR 95% CI: 0.813-6.87
Binary weak
184.11 Malignant neoplasm of ovary
High-grade serous ovarian cancer
MGI Fixed threshold (5e-06) Phelan CM et al. 2017 14 0.36 0.0008 0.0829 0.514
0.472-0.558
0
OR 95% CI: 0-0
Binary weak
184.11 Malignant neoplasm of ovary
Low-grade serous and serous borderline ovarian cancer
MGI PRS-CS Phelan CM et al. 2017 1114056 0.36 0.0004 0.0829 0.528
0.482-0.572
1.36
OR 95% CI: 0.348-5.29
Binary weak
184.11 Malignant neoplasm of ovary
Epithelial ovarian cancer
MGI lassosum Phelan CM et al. 2017 59 0.36 0.0056 0.0829 0.552
0.511-0.593
0
OR 95% CI: 0-0
Binary weak
187.2 Malignant neoplasm of testis
ICD-10 C62 Malignant neoplasm of testis
MGI Fixed threshold (5e-07) UKB GWAS (ICD10) 5 0.36 0.0017 0.086 0.529
0.461-0.601
0
OR 95% CI: 0-0
Binary weak
189.11 Malignant neoplasm of kidney, except pelvis
Self-reported kidney/renal cell cancer
MGI Fixed threshold (5e-06) UKB GWAS (PHESANT) 13 0.36 0.0002 0.0827 0.491
0.466-0.518
2.32
OR 95% CI: 1.24-4.33
Binary weak
202 Cancer of other lymphoid, histiocytic tissue
Marginal zone lymphoma;Waldenström macroglobulinemia / lymphoplasmacytic lymphoma (GWAS Catalog (2019-05-03))
MGI lassosum UKB GWAS (PheCode) 39308 0.36 0.0009 0.0827 0.509
0.484-0.535
2.41
OR 95% CI: 1.37-4.24
Binary weak
209 Neuroendocrine tumors
Neuroblastoma;Neuroblastoma (high-risk);Sporadic neuroblastoma;Neuroblastoma (11q deletion)
MGI Fixed threshold (5e-05) GWAS Catalog (2019-05-03) 10 0.36 0.0004 0.0826 0.517
0.459-0.572
1.18
OR 95% CI: 0.204-6.85
Binary weak
209 Neuroendocrine tumors
Neuroblastoma;Neuroblastoma (high-risk);Sporadic neuroblastoma;Neuroblastoma (11q deletion)
MGI Fixed threshold (5e-06) GWAS Catalog (2019-05-03) 10 0.36 0.0004 0.0826 0.517
0.459-0.572
1.18
OR 95% CI: 0.204-6.85
Binary weak
209 Neuroendocrine tumors
Neuroblastoma;Neuroblastoma (high-risk);Sporadic neuroblastoma;Neuroblastoma (11q deletion)
MGI Fixed threshold (5e-07) GWAS Catalog (2019-05-03) 10 0.36 0.0004 0.0826 0.517
0.459-0.572
1.18
OR 95% CI: 0.204-6.85
Binary weak
209 Neuroendocrine tumors
Neuroblastoma;Neuroblastoma (high-risk);Sporadic neuroblastoma;Neuroblastoma (11q deletion)
MGI GWAS Hits GWAS Catalog (2019-05-03) 10 0.36 0.0004 0.0826 0.517
0.459-0.572
1.18
OR 95% CI: 0.204-6.85
Binary weak
153.2 Colon cancer
Self-reported colon cancer/sigmoid cancer
MGI lassosum UKB GWAS (PHESANT) 5818307 0.37 0.0009 0.0833 0.513
0.485-0.538
0.948
OR 95% CI: 0.356-2.53
Binary weak
165.1 Cancer of bronchus; lung
Lung cancer and mesothelioma
MGI lassosum UKB GWAS (FINNGEN) 73073 0.37 0.0009 0.0828 0.516
0.488-0.546
0.564
OR 95% CI: 0.155-2.05
Binary weak
165.1 Cancer of bronchus; lung
Lung cancer and mesothelioma
MGI lassosum UKB GWAS (FINNGEN) 73073 0.37 0.0009 0.0828 0.516
0.488-0.546
0.564
OR 95% CI: 0.155-2.05
Binary weak
190 Cancer of eye
Malignant neoplasm of eye and adnexa
MGI lassosum UKB GWAS (FINNGEN) 195920 0.37 0.0146 0.0837 0.534
0.456-0.608
1.91
OR 95% CI: 0.296-12.4
Binary weak
201 Hodgkin's disease
ICD-10 C81 Hodgkin's disease
MGI lassosum UKB GWAS (ICD10) 31680 0.37 0.0107 0.0831 0.521
0.455-0.59
1.82
OR 95% CI: 0.289-11.5
Binary weak
204.1 Lymphoid leukemia
MGI Fixed threshold (5e-05) UKB GWAS (PheCode) 113 0.37 0.0051 0.0825 0.523
0.452-0.591
5.09
OR 95% CI: 1.53-16.9
Binary weak
204.11 Lymphoid leukemia, acute
Acute lymphoblastic leukemia (childhood);Acute lymphoblastic leukemia (B-cell precursor);Acute lymphoblastic leukemia in childhood (B cell precursor)
MGI Fixed threshold (5e-09) GWAS Catalog (2019-05-03) 5 0.37 0.0053 0.0826 0.534
0.426-0.65
2.64
OR 95% CI: 0.348-20
Binary weak
145.2 Cancer of tongue
Malignant neoplasm of other and unspecified parts of tongue (UKB GWAS (FINNGEN))
MGI PRS-CS UKB GWAS (PheCode) 1119238 0.38 0 0.0828 0.523
0.486-0.559
0.928
OR 95% CI: 0.247-3.48
Binary weak
159.3 Malignant neoplasm of gallbladder and extrahepatic bile ducts
MGI PRS-CS UKB GWAS (PheCode) 1119238 0.38 0.0027 0.0825 0.529
0.454-0.599
5.32
OR 95% CI: 1.56-18.2
Binary weak
170.1 Bone cancer
Self-reported primary bone cancer
MGI Fixed threshold (5e-05) UKB GWAS (PHESANT) 48 0.38 0.0002 0.0829 0.512
0.479-0.546
1.59
OR 95% CI: 0.635-3.97
Binary weak
172.2 Other non-epithelial cancer of skin
Self-reported non-melanoma skin cancer
MGI Fixed threshold (5e-06) UKB GWAS (PHESANT) 18 0.38 0.0001 0.139 0.494
0.483-0.506
1.6
OR 95% CI: 1.12-2.28
Binary weak
172.21 Basal cell carcinoma
Self-reported rodent ulcer
MGI Fixed threshold (5e-05) UKB GWAS (PHESANT) 96 0.38 0.0003 0.109 0.5
0.484-0.516
1.03
OR 95% CI: 0.582-1.8
Binary weak
184.11 Malignant neoplasm of ovary
High-grade serous ovarian cancer
MGI P&T Phelan CM et al. 2017 9 0.38 0.0014 0.0829 0.52
0.48-0.56
0.774
OR 95% CI: 0.14-4.27
Binary weak
187.2 Malignant neoplasm of testis
ICD-10 C62 Malignant neoplasm of testis
MGI Fixed threshold (5e-05) UKB GWAS (ICD10) 76 0.38 0.0003 0.086 0.532
0.459-0.598
0
OR 95% CI: 0-0
Binary weak
187.2 Malignant neoplasm of testis
ICD-10 C62 Malignant neoplasm of testis
MGI P&T UKB GWAS (ICD10) 10 0.38 0.0024 0.086 0.528
0.459-0.597
1.68
OR 95% CI: 0.25-11.2
Binary weak
191.1 Cancer of brain and nervous system
Malignant neoplasm of eye, brain and central nervous system
MGI P&T UKB GWAS (FINNGEN) 36 0.38 0.0005 0.0826 0.508
0.47-0.543
0
OR 95% CI: 0-0
Binary weak
201 Hodgkin's disease
Hodgkin lymphoma
MGI P&T UKB GWAS (FINNGEN) 117 0.38 0.0177 0.083 0.526
0.455-0.593
0
OR 95% CI: 0-0
Binary weak
191.11 Cancer of brain
Glioblastoma (GWAS Catalog (2019-05-03))
MGI Fixed threshold (5e-05) UKB GWAS (PheCode) 94 0.39 0.0016 0.0826 0.513
0.474-0.55
1.01
OR 95% CI: 0.269-3.82
Binary weak
191.11 Cancer of brain
Malignant neoplasm of brain
MGI PRS-CS UKB GWAS (FINNGEN) 1050964 0.39 0.0004 0.0826 0.508
0.471-0.549
1.43
OR 95% CI: 0.454-4.49
Binary weak
194 Cancer of other endocrine glands
Malignant neoplasm of endocrine gland
MGI Fixed threshold (5e-05) UKB GWAS (FINNGEN) 82 0.39 0.0003 0.0827 0.507
0.447-0.567
4.01
OR 95% CI: 1.27-12.6
Binary weak
202.21 Nodular lymphoma
Follicular lymphoma
MGI Fixed threshold (5e-05) UKB GWAS (FINNGEN) 103 0.39 0.0001 0.0826 0.502
0.47-0.535
2.16
OR 95% CI: 0.908-5.13
Binary weak
204.22 Myeloid leukemia, chronic
MGI P&T UKB GWAS (PheCode) 62 0.39 0.0247 0.0825 0.538
0.433-0.645
4.58
OR 95% CI: 0.489-42.8
Binary weak
165.1 Cancer of bronchus; lung
Self-reported lung cancer
MGI lassosum UKB GWAS (PHESANT) 5700 0.4 0.0028 0.0828 0.513
0.484-0.541
0.801
OR 95% CI: 0.266-2.41
Binary weak
182 Malignant neoplasm of uterus
Endometrial cancer;Endometrial cancer (endometrioid histology);Endometrial endometrioid carcinoma;Endometrial cancer (Non-endometrioid histology) (GWAS Catalog (2019-05-03))
MGI Fixed threshold (5e-06) UKB GWAS (PheCode) 10 0.4 0.0008 0.0832 0.51
0.478-0.542
0.736
OR 95% CI: 0.2-2.71
Binary weak
184.11 Malignant neoplasm of ovary
Invasive epithelial ovarian cancer
MGI Fixed threshold (5e-05) Phelan CM et al. 2017 219 0.4 0 0.0829 0.527
0.488-0.57
0.814
OR 95% CI: 0.148-4.49
Binary weak
184.11 Malignant neoplasm of ovary
Diagnoses - main ICD10: C56 Malignant neoplasm of ovary (UKB GWAS (ICD10))
MGI PRS-CS UKB GWAS (FINNGEN) 1095247 0.4 0.0027 0.0829 0.525
0.478-0.568
1.26
OR 95% CI: 0.323-4.94
Binary weak
187.2 Malignant neoplasm of testis
ICD-10 C62 Malignant neoplasm of testis
MGI Fixed threshold (5e-06) UKB GWAS (ICD10) 13 0.4 0.0008 0.086 0.534
0.468-0.604
1.53
OR 95% CI: 0.217-10.8
Binary weak
187.2 Malignant neoplasm of testis
Diagnoses - main ICD10: C62 Malignant neoplasm of testis (UKB GWAS (ICD10))
MGI PRS-CS UKB GWAS (FINNGEN) 1061611 0.4 0.009 0.0861 0.531
0.468-0.594
0
OR 95% CI: 0-0
Binary weak
204.11 Lymphoid leukemia, acute
Acute lymphoblastic leukemia (childhood);Acute lymphoblastic leukemia (B-cell precursor);Acute lymphoblastic leukemia in childhood (B cell precursor)
MGI P&T GWAS Catalog (2019-05-03) 21 0.4 0.0092 0.0826 0.559
0.461-0.657
0
OR 95% CI: 0-0
Binary weak
204.2 Myeloid leukemia
ICD-10 C92 Myeloid leukaemia
MGI P&T UKB GWAS (ICD10) 8 0.4 0.011 0.0826 0.514
0.458-0.576
0
OR 95% CI: 0-0
Binary weak
157 Pancreatic cancer
Malignant neoplasm of pancreas
MGI lassosum UKB GWAS (FINNGEN) 174 0.41 0.0046 0.0828 0.506
0.464-0.55
1.11
OR 95% CI: 0.292-4.21
Binary weak
184.11 Malignant neoplasm of ovary
Endometrioid ovarian cancer
MGI PRS-CS Phelan CM et al. 2017 1114056 0.41 0 0.0829 0.523
0.479-0.573
2.49
OR 95% CI: 0.858-7.24
Binary weak
157 Pancreatic cancer
ICD-10 C25 Malignant neoplasm of pancreas
MGI P&T UKB GWAS (ICD10) 6 0.42 0.0006 0.0828 0.486
0.445-0.529
2.01
OR 95% CI: 0.711-5.67
Binary weak
182 Malignant neoplasm of uterus
Self-reported uterine/endometrial cancer
MGI Fixed threshold (5e-05) UKB GWAS (PHESANT) 115 0.42 0.0014 0.0832 0.511
0.478-0.544
0.722
OR 95% CI: 0.196-2.66
Binary weak
182 Malignant neoplasm of uterus
Self-reported uterine/endometrial cancer
MGI P&T UKB GWAS (PHESANT) 115 0.42 0.0014 0.0832 0.511
0.478-0.544
0.722
OR 95% CI: 0.196-2.66
Binary weak
184.11 Malignant neoplasm of ovary
High-grade serous ovarian cancer
MGI lassosum Phelan CM et al. 2017 20012 0.42 0.0049 0.0829 0.516
0.475-0.56
0.824
OR 95% CI: 0.149-4.55
Binary weak
187.2 Malignant neoplasm of testis
ICD-10 C62 Malignant neoplasm of testis
MGI lassosum UKB GWAS (ICD10) 2944812 0.42 0.0041 0.0861 0.527
0.461-0.599
0
OR 95% CI: 0-0
Binary weak
194 Cancer of other endocrine glands
Malignant neoplasm of endocrine gland
MGI P&T UKB GWAS (FINNGEN) 123 0.42 0.0044 0.0828 0.519
0.46-0.579
1.3
OR 95% CI: 0.223-7.59
Binary weak
204.4 Multiple myeloma
and malignant plasma cell neoplasms
MGI PRS-CS UKB GWAS (FINNGEN) 1060905 0.42 0.0006 0.0827 0.531
0.47-0.596
1.5
OR 95% CI: 0.243-9.19
Binary weak
145.2 Cancer of tongue
Self-reported tongue cancer
MGI Fixed threshold (5e-05) UKB GWAS (PHESANT) 41 0.43 0 0.0828 0.511
0.477-0.547
0.929
OR 95% CI: 0.248-3.49
Binary weak
153.3 Malignant neoplasm of rectum, rectosigmoid junction, and anus
Malignant neoplasm of anus and anal canal
MGI lassosum UKB GWAS (FINNGEN) 79687 0.43 0.0018 0.083 0.527
0.493-0.558
1.34
OR 95% CI: 0.493-3.65
Binary weak
172.3 Carcinoma in situ of skin
ICD-10 D04 Carcinoma in situ of skin
MGI P&T UKB GWAS (ICD10) 65 0.43 0.0021 0.094 0.503
0.479-0.528
0.9
OR 95% CI: 0.368-2.2
Binary weak
184.11 Malignant neoplasm of ovary
Mucinous ovarian carcinoma
UKB lassosum Phelan CM et al. 2017 1467601 0.43 0.0028 0.0827 0.507
0.48-0.534
1.13
OR 95% CI: 0.464-2.77
Binary weak
200.1 Polycythemia vera
MGI Fixed threshold (5e-06) UKB GWAS (PheCode) 19 0.43 0.0001 0.0826 0.513
0.453-0.577
1.58
OR 95% CI: 0.256-9.73
Binary weak
202 Cancer of other lymphoid, histiocytic tissue
Marginal zone lymphoma;Waldenström macroglobulinemia / lymphoplasmacytic lymphoma
MGI Fixed threshold (5e-05) GWAS Catalog (2019-05-03) 7 0.43 0.0004 0.0827 0.46
0.441-0.48
1.78
OR 95% CI: 0.943-3.36
Binary weak
202 Cancer of other lymphoid, histiocytic tissue
Marginal zone lymphoma;Waldenström macroglobulinemia / lymphoplasmacytic lymphoma
MGI Fixed threshold (5e-06) GWAS Catalog (2019-05-03) 7 0.43 0.0004 0.0827 0.46
0.441-0.48
1.78
OR 95% CI: 0.943-3.36
Binary weak
202 Cancer of other lymphoid, histiocytic tissue
Marginal zone lymphoma;Waldenström macroglobulinemia / lymphoplasmacytic lymphoma
MGI Fixed threshold (5e-07) GWAS Catalog (2019-05-03) 5 0.43 0.0003 0.0827 0.456
0.438-0.476
1.94
OR 95% CI: 1.05-3.58
Binary weak
202 Cancer of other lymphoid, histiocytic tissue
Marginal zone lymphoma;Waldenström macroglobulinemia / lymphoplasmacytic lymphoma
MGI P&T GWAS Catalog (2019-05-03) 7 0.43 0.0004 0.0827 0.46
0.441-0.48
1.78
OR 95% CI: 0.943-3.36
Binary weak
202 Cancer of other lymphoid, histiocytic tissue
Lymphomas
MGI lassosum UKB GWAS (FINNGEN) 215 0.43 0.0005 0.0827 0.478
0.458-0.501
0.993
OR 95% CI: 0.44-2.24
Binary weak
204.4 Multiple myeloma
Multiple myeloma (hyperdiploidy);Multiple myeloma (IgH translocation);Multiple myeloma;Multiple myeloma and monoclonal gammopathy (GWAS Catalog (2019-05-03))
MGI PRS-CS UKB GWAS (PheCode) 1119238 0.43 0 0.0827 0.532
0.467-0.599
1.52
OR 95% CI: 0.25-9.32
Binary weak
149.4 Cancer of larynx
ICD-10 C32 Malignant neoplasm of larynx
MGI P&T UKB GWAS (ICD10) 106 0.44 0.0018 0.0826 0.518
0.472-0.567
2.16
OR 95% CI: 0.642-7.25
Binary weak
149.4 Cancer of larynx
Malignant neoplasm of larynx
MGI PRS-CS UKB GWAS (FINNGEN) 978910 0.44 0.001 0.0826 0.526
0.479-0.571
0
OR 95% CI: 0-0
Binary weak
153.3 Malignant neoplasm of rectum, rectosigmoid junction, and anus
ICD-10 C21 Malignant neoplasm of anus and anal canal
MGI Fixed threshold (5e-05) UKB GWAS (ICD10) 64 0.44 0.0026 0.083 0.509
0.475-0.544
1.05
OR 95% CI: 0.343-3.22
Binary weak
165 Cancer within the respiratory system
MGI Fixed threshold (5e-07) UKB GWAS (PheCode) 5 0.44 0 0.0827 0.505
0.477-0.532
1.37
OR 95% CI: 0.595-3.14
Binary weak
180.1 Cervical cancer
Cancer code, self-reported: cervical cancer (UKB GWAS (PHESANT))
MGI PRS-CS UKB GWAS (PheCode) 1119236 0.44 0.0004 0.0826 0.51
0.471-0.548
3.78
OR 95% CI: 1.68-8.53
Binary weak
184.11 Malignant neoplasm of ovary
Epithelial ovarian cancer
MGI Fixed threshold (5e-06) Phelan CM et al. 2017 26 0.44 0.0004 0.0829 0.525
0.481-0.57
1.34
OR 95% CI: 0.343-5.22
Binary weak
189.2 Cancer of bladder
Self-reported bladder cancer
MGI P&T UKB GWAS (PHESANT) 155 0.44 0.0021 0.0923 0.507
0.488-0.527
0.549
OR 95% CI: 0.21-1.44
Binary weak
201 Hodgkin's disease
Hodgkin's lymphoma;Nodular sclerosis Hodgkin lymphoma
UKB GWAS Hits GWAS Catalog (2019-05-03) 16 0.44 0.0453 0.0821 0.507
0.449-0.56
1.88
OR 95% CI: 0.464-7.64
Binary weak
202.2 Non-Hodgkin lymphoma
Other and unspecified types of non-Hodgkin lymphoma
MGI PRS-CS UKB GWAS (FINNGEN) 1054742 0.44 0 0.0827 0.505
0.481-0.529
1.95
OR 95% CI: 1.02-3.7
Binary weak
153.3 Malignant neoplasm of rectum, rectosigmoid junction, and anus
Diagnoses - main ICD10: C21 Malignant neoplasm of anus and anal canal (UKB GWAS (ICD10))
MGI Fixed threshold (5e-06) UKB GWAS (PheCode) 17 0.45 0.001 0.083 0.502
0.466-0.533
1.63
OR 95% CI: 0.651-4.09
Binary weak
153.3 Malignant neoplasm of rectum, rectosigmoid junction, and anus
Malignant neoplasm of rectum
MGI lassosum UKB GWAS (FINNGEN) 1249593 0.45 0.0007 0.083 0.508
0.473-0.541
1.34
OR 95% CI: 0.493-3.66
Binary weak
159 Malignant neoplasm of other and ill-defined sites within the digestive organs and peritoneum
Malignant neoplasm of digestive organs
MGI Fixed threshold (5e-05) UKB GWAS (FINNGEN) 130 0.45 0.0003 0.0826 0.508
0.477-0.538
2.43
OR 95% CI: 1.18-5
Binary weak
184.11 Malignant neoplasm of ovary
Ovarian clear cell cancer
UKB P&T Phelan CM et al. 2017 84 0.45 0.0028 0.0827 0.51
0.482-0.538
1.76
OR 95% CI: 0.839-3.7
Binary weak
202 Cancer of other lymphoid, histiocytic tissue
Non-follicular lymphoma
MGI P&T UKB GWAS (FINNGEN) 12 0.45 0.0017 0.0827 0.496
0.472-0.52
1.59
OR 95% CI: 0.824-3.09
Binary weak
204.1 Lymphoid leukemia
MGI P&T UKB GWAS (PheCode) 10 0.45 0.0178 0.0826 0.498
0.442-0.561
1.57
OR 95% CI: 0.256-9.66
Binary weak
204.2 Myeloid leukemia
ICD-10 C92 Myeloid leukaemia
MGI Fixed threshold (5e-06) UKB GWAS (ICD10) 9 0.45 0.0074 0.0826 0.51
0.454-0.572
3.04
OR 95% CI: 0.866-10.7
Binary weak
153 Colorectal cancer
Self-reported large bowel cancer/colorectal cancer
MGI Fixed threshold (5e-05) UKB GWAS (PHESANT) 99 0.46 0.0005 0.0831 0.505
0.482-0.527
1.38
OR 95% CI: 0.668-2.86
Binary weak
180.1 Cervical cancer
Cancer code, self-reported: cervical cancer (UKB GWAS (PHESANT))
MGI P&T UKB GWAS (PheCode) 5 0.46 0.0015 0.0826 0.492
0.454-0.531
1.04
OR 95% CI: 0.273-3.95
Binary weak
187 Cancer of other male genital organs
malignant neoplasm of male genital organs
MGI PRS-CS UKB GWAS (FINNGEN) 1111493 0.46 0.0014 0.0833 0.519
0.47-0.57
1.67
OR 95% CI: 0.416-6.72
Binary weak
191.1 Cancer of brain and nervous system
Glioma;Non-glioblastoma glioma;Glioma (high-grade) (GWAS Catalog (2019-05-03))
MGI Fixed threshold (5e-05) UKB GWAS (PheCode) 114 0.46 0.003 0.0826 0.506
0.472-0.54
2.31
OR 95% CI: 0.967-5.53
Binary weak
191.11 Cancer of brain
Self-reported brain cancer / primary malignant brain tumour
MGI P&T UKB GWAS (PHESANT) 82 0.46 0.0005 0.0826 0.512
0.473-0.55
0.603
OR 95% CI: 0.113-3.22
Binary weak
194 Cancer of other endocrine glands
Malignant neoplasm of endocrine gland
MGI lassosum UKB GWAS (FINNGEN) 11722 0.46 0.0056 0.0828 0.514
0.458-0.566
2.18
OR 95% CI: 0.522-9.12
Binary weak
200 Myeloproliferative disease
MGI Fixed threshold (5e-07) UKB GWAS (PheCode) 5 0.46 0.0004 0.0826 0.493
0.464-0.521
1.46
OR 95% CI: 0.632-3.36
Binary weak
157 Pancreatic cancer
Malignant neoplasm of pancreas
MGI PRS-CS UKB GWAS (FINNGEN) 1062840 0.47 0.0001 0.0829 0.506
0.464-0.548
2.49
OR 95% CI: 0.954-6.52
Binary weak
190 Cancer of eye
Malignant neoplasm of eye and adnexa (UKB GWAS (FINNGEN))
MGI PRS-CS UKB GWAS (PheCode) 1119238 0.47 0.0002 0.0837 0.53
0.459-0.603
1.88
OR 95% CI: 0.29-12.1
Binary weak
202.2 Non-Hodgkin lymphoma
Diffuse large B cell lymphoma;Follicular lymphoma
MGI Fixed threshold (5e-09) GWAS Catalog (2019-05-03) 11 0.47 0.0051 0.0827 0.498
0.476-0.522
0.912
OR 95% CI: 0.377-2.21
Binary weak
153.2 Colon cancer
ICD-10 C18 Malignant neoplasm of colon
MGI Fixed threshold (5e-06) UKB GWAS (ICD10) 24 0.49 0.0005 0.0833 0.5
0.473-0.527
0.966
OR 95% CI: 0.362-2.58
Binary weak
165.1 Cancer of bronchus; lung
Self-reported lung cancer
MGI Fixed threshold (5e-06) UKB GWAS (PHESANT) 10 0.49 0 0.0828 0.492
0.463-0.519
1.71
OR 95% CI: 0.777-3.76
Binary weak
182 Malignant neoplasm of uterus
Self-reported uterine/endometrial cancer
MGI PRS-CS UKB GWAS (PHESANT) 1097611 0.49 0 0.0832 0.508
0.475-0.539
1.03
OR 95% CI: 0.335-3.14
Binary weak
184.11 Malignant neoplasm of ovary
ICD-10 C56 Malignant neoplasm of ovary
MGI Fixed threshold (5e-05) UKB GWAS (ICD10) 101 0.49 0 0.0829 0.505
0.459-0.551
1.35
OR 95% CI: 0.347-5.26
Binary weak
191.11 Cancer of brain
ICD-10 C71 Malignant neoplasm of brain
MGI PRS-CS UKB GWAS (ICD10) 1055124 0.49 0.0002 0.0826 0.514
0.476-0.556
0.607
OR 95% CI: 0.113-3.25
Binary weak
191.11 Cancer of brain
Malignant neoplasm of brain
MGI lassosum UKB GWAS (FINNGEN) 3656328 0.49 0.0005 0.0826 0.51
0.473-0.545
1.84
OR 95% CI: 0.658-5.17
Binary weak
204.22 Myeloid leukemia, chronic
MGI Fixed threshold (5e-05) UKB GWAS (PheCode) 72 0.49 0.0062 0.0825 0.53
0.423-0.642
4.48
OR 95% CI: 0.473-42.5
Binary weak
170.2 Cancer of connective tissue
MGI lassosum UKB GWAS (PheCode) 534767 0.5 0.0017 0.0828 0.511
0.486-0.535
0.807
OR 95% CI: 0.306-2.13
Binary weak
182 Malignant neoplasm of uterus
ICD-10 C54 Malignant neoplasm of corpus uteri
MGI lassosum UKB GWAS (ICD10) 2360050 0.5 0.0033 0.0832 0.511
0.478-0.543
0.73
OR 95% CI: 0.198-2.69
Binary weak
202.21 Nodular lymphoma
MGI PRS-CS UKB GWAS (PheCode) 1119238 0.5 0 0.0826 0.508
0.473-0.542
0.485
OR 95% CI: 0.092-2.56
Binary weak
145.2 Cancer of tongue
Malignant neoplasm of other and unspecified parts of tongue
MGI Fixed threshold (5e-06) UKB GWAS (FINNGEN) 10 0.51 0.0006 0.0828 0.505
0.469-0.542
1.71
OR 95% CI: 0.618-4.76
Binary weak
150 Cancer of esophagus
Esophageal adenocarcinoma (GWAS Catalog (2019-05-03))
MGI Fixed threshold (5e-05) UKB GWAS (PheCode) 105 0.51 0.0003 0.0828 0.51
0.472-0.555
1.27
OR 95% CI: 0.328-4.89
Binary weak
159.2 Malignant neoplasm of small intestine, including duodenum
Self-reported small intestine/small bowel cancer
MGI Fixed threshold (5e-05) UKB GWAS (PHESANT) 59 0.51 0.0005 0.0826 0.501
0.435-0.568
4.18
OR 95% CI: 1.11-15.8
Binary weak
172.2 Other non-epithelial cancer of skin
Self-reported non-melanoma skin cancer
MGI Fixed threshold (5e-05) UKB GWAS (PHESANT) 112 0.51 0.0001 0.139 0.501
0.49-0.513
0.868
OR 95% CI: 0.565-1.33
Binary weak
172.3 Carcinoma in situ of skin
ICD-10 D04 Carcinoma in situ of skin
MGI lassosum UKB GWAS (ICD10) 118 0.51 0.0039 0.094 0.504
0.48-0.528
1.1
OR 95% CI: 0.481-2.54
Binary weak
184.11 Malignant neoplasm of ovary
Mucinous ovarian carcinoma
UKB P&T Phelan CM et al. 2017 45 0.51 0.0053 0.0827 0.51
0.481-0.538
0.924
OR 95% CI: 0.348-2.46
Binary weak
189.2 Cancer of bladder
Malignant neoplasm of bladder
MGI Fixed threshold (5e-05) UKB GWAS (FINNGEN) 125 0.51 0 0.0923 0.502
0.481-0.523
1.01
OR 95% CI: 0.489-2.07
Binary weak
189.2 Cancer of bladder
Malignant neoplasm of bladder
MGI P&T UKB GWAS (FINNGEN) 5 0.51 0.0007 0.0923 0.468
0.449-0.487
0.767
OR 95% CI: 0.34-1.73
Binary weak
202 Cancer of other lymphoid, histiocytic tissue
Non-follicular lymphoma
MGI Fixed threshold (5e-06) UKB GWAS (FINNGEN) 18 0.51 0.001 0.0827 0.495
0.472-0.519
0.675
OR 95% CI: 0.257-1.77
Binary weak
204.11 Lymphoid leukemia, acute
Acute lymphoblastic leukemia (childhood);Acute lymphoblastic leukemia (B-cell precursor);Acute lymphoblastic leukemia in childhood (B cell precursor)
MGI Fixed threshold (5e-07) GWAS Catalog (2019-05-03) 10 0.51 0.0024 0.0827 0.543
0.451-0.632
0
OR 95% CI: 0-0
Binary weak
204.4 Multiple myeloma
(hyperdiploidy);Multiple myeloma (IgH translocation);Multiple myeloma;Multiple myeloma and monoclonal gammopathy
MGI Fixed threshold (5e-06) GWAS Catalog (2019-05-03) 45 0.51 0.0241 0.0827 0.516
0.443-0.583
0
OR 95% CI: 0-0
Binary weak
204.4 Multiple myeloma
(hyperdiploidy);Multiple myeloma (IgH translocation);Multiple myeloma;Multiple myeloma and monoclonal gammopathy
MGI P&T GWAS Catalog (2019-05-03) 45 0.51 0.0241 0.0827 0.516
0.443-0.583
0
OR 95% CI: 0-0
Binary weak
153.2 Colon cancer
Self-reported colon cancer/sigmoid cancer
MGI P&T UKB GWAS (PHESANT) 11 0.52 0.0011 0.0833 0.492
0.467-0.521
0.73
OR 95% CI: 0.243-2.19
Binary weak
153.3 Malignant neoplasm of rectum, rectosigmoid junction, and anus
ICD-10 C21 Malignant neoplasm of anus and anal canal
MGI Fixed threshold (5e-06) UKB GWAS (ICD10) 16 0.52 0.0027 0.083 0.499
0.467-0.535
0.444
OR 95% CI: 0.0847-2.33
Binary weak
170.1 Bone cancer
Self-reported primary bone cancer
MGI PRS-CS UKB GWAS (PHESANT) 839358 0.52 0.0013 0.0829 0.51
0.478-0.543
1.31
OR 95% CI: 0.482-3.57
Binary weak
184.11 Malignant neoplasm of ovary
ICD-10 C56 Malignant neoplasm of ovary
MGI Fixed threshold (5e-06) UKB GWAS (ICD10) 10 0.52 0.0007 0.0829 0.496
0.449-0.541
1.41
OR 95% CI: 0.36-5.49
Binary weak
187.2 Malignant neoplasm of testis
Diagnoses - main ICD10: C62 Malignant neoplasm of testis (UKB GWAS (ICD10))
MGI Fixed threshold (5e-06) UKB GWAS (PheCode) 41 0.52 0.003 0.0861 0.525
0.461-0.588
0
OR 95% CI: 0-0
Binary weak
202.2 Non-Hodgkin lymphoma
Other and unspecified types of non-Hodgkin lymphoma
MGI Fixed threshold (5e-05) UKB GWAS (FINNGEN) 80 0.52 0.0001 0.0827 0.505
0.48-0.53
0.747
OR 95% CI: 0.284-1.97
Binary weak
150 Cancer of esophagus
ICD-10 C15 Malignant neoplasm of oesophagus
MGI Fixed threshold (5e-06) UKB GWAS (ICD10) 25 0.53 0.0012 0.0828 0.51
0.462-0.551
0
OR 95% CI: 0-0
Binary weak
184.11 Malignant neoplasm of ovary
Diagnoses - main ICD10: C56 Malignant neoplasm of ovary (UKB GWAS (ICD10))
MGI P&T UKB GWAS (FINNGEN) 193 0.53 0.0009 0.0829 0.513
0.469-0.556
0.826
OR 95% CI: 0.15-4.56
Binary weak
182 Malignant neoplasm of uterus
Endometrial cancer;Endometrial cancer (endometrioid histology);Endometrial endometrioid carcinoma;Endometrial cancer (Non-endometrioid histology) (GWAS Catalog (2019-05-03))
MGI lassosum UKB GWAS (PheCode) 333485 0.54 0.0049 0.0832 0.513
0.48-0.543
0.729
OR 95% CI: 0.198-2.69
Binary weak
202.2 Non-Hodgkin lymphoma
Diffuse large B cell lymphoma;Follicular lymphoma
MGI GWAS Hits GWAS Catalog (2019-05-03) 12 0.54 0.0047 0.0827 0.496
0.474-0.52
1.08
OR 95% CI: 0.474-2.44
Binary weak
204.4 Multiple myeloma
(hyperdiploidy);Multiple myeloma (IgH translocation);Multiple myeloma;Multiple myeloma and monoclonal gammopathy
MGI Fixed threshold (5e-05) GWAS Catalog (2019-05-03) 54 0.54 0.0108 0.0827 0.509
0.436-0.58
1.23
OR 95% CI: 0.194-7.84
Binary weak
204.4 Multiple myeloma
Self-reported multiple myeloma
MGI PRS-CS UKB GWAS (PHESANT) 872863 0.54 0.0021 0.0827 0.513
0.448-0.579
0
OR 95% CI: 0-0
Binary weak
155 Cancer of liver and intrahepatic bile duct
ICD-10 C22 Malignant neoplasm of liver and intrahepatic bile ducts
MGI P&T UKB GWAS (ICD10) 9 0.55 0.0017 0.0826 0.498
0.459-0.536
1.62
OR 95% CI: 0.51-5.18
Binary weak
172.2 Other non-epithelial cancer of skin
Self-reported non-melanoma skin cancer
MGI P&T UKB GWAS (PHESANT) 177 0.55 0.0008 0.139 0.5
0.489-0.512
1.12
OR 95% CI: 0.756-1.65
Binary weak
202 Cancer of other lymphoid, histiocytic tissue
Primary_lymphoid and hematopoietic malignant neoplasms
MGI Fixed threshold (5e-06) UKB GWAS (FINNGEN) 19 0.55 0 0.0827 0.487
0.464-0.509
0.838
OR 95% CI: 0.348-2.02
Binary weak
202 Cancer of other lymphoid, histiocytic tissue
Lymphomas
MGI PRS-CS UKB GWAS (FINNGEN) 1109478 0.55 0.0003 0.0827 0.505
0.482-0.527
1.16
OR 95% CI: 0.539-2.49
Binary weak
149.1 Cancer of oropharynx
MGI lassosum UKB GWAS (PheCode) 442201 0.56 0.0026 0.083 0.515
0.464-0.561
2.41
OR 95% CI: 0.715-8.1
Binary weak
165.1 Cancer of bronchus; lung
Doctor diagnosed lung cancer (not mesothelioma)
MGI Fixed threshold (5e-05) UKB GWAS (PHESANT) 32 0.56 0.0007 0.0828 0.504
0.475-0.532
0.337
OR 95% CI: 0.065-1.74
Binary weak
170 Cancer of bone and connective tissue
MGI P&T UKB GWAS (PheCode) 27 0.56 0.0004 0.083 0.493
0.471-0.514
0.826
OR 95% CI: 0.368-1.85
Binary weak
170.2 Cancer of connective tissue
MGI Fixed threshold (5e-06) UKB GWAS (PheCode) 11 0.56 0.0003 0.0828 0.474
0.45-0.5
1.16
OR 95% CI: 0.51-2.65
Binary weak
202 Cancer of other lymphoid, histiocytic tissue
Marginal zone lymphoma;Waldenström macroglobulinemia / lymphoplasmacytic lymphoma (GWAS Catalog (2019-05-03))
MGI PRS-CS UKB GWAS (PheCode) 1119238 0.56 0.0001 0.0827 0.51
0.487-0.531
1.31
OR 95% CI: 0.635-2.7
Binary weak
155.1 Malignant neoplasm of liver, primary
MGI Fixed threshold (5e-06) UKB GWAS (PheCode) 9 0.57 0.0011 0.0825 0.484
0.435-0.534
2.21
OR 95% CI: 0.664-7.38
Binary weak
170.2 Cancer of connective tissue
ICD-10 C49 Malignant neoplasm of other connective and soft tissue
MGI lassosum UKB GWAS (ICD10) 394653 0.57 0.0006 0.0828 0.506
0.482-0.532
1.17
OR 95% CI: 0.514-2.66
Binary weak
184.11 Malignant neoplasm of ovary
ICD-10 C56 Malignant neoplasm of ovary
MGI PRS-CS UKB GWAS (ICD10) 1091510 0.57 0.0001 0.0829 0.518
0.474-0.56
3.09
OR 95% CI: 1.15-8.29
Binary weak
170.2 Cancer of connective tissue
MGI P&T UKB GWAS (PheCode) 6 0.58 0.001 0.0828 0.456
0.435-0.477
1.35
OR 95% CI: 0.623-2.92
Binary weak
184.11 Malignant neoplasm of ovary
Low-grade serous ovarian cancer
MGI P&T Phelan CM et al. 2017 176 0.58 0.0021 0.0829 0.521
0.475-0.565
0.792
OR 95% CI: 0.143-4.38
Binary weak
189.1 Cancer of kidney and renal pelvis
MGI P&T UKB GWAS (PheCode) 162 0.58 0.0004 0.0827 0.501
0.478-0.523
1.04
OR 95% CI: 0.461-2.36
Binary weak
191.1 Cancer of brain and nervous system
Glioma;Non-glioblastoma glioma;Glioma (high-grade)
MGI Fixed threshold (5e-09) GWAS Catalog (2019-05-03) 20 0.58 0.0047 0.0826 0.501
0.465-0.535
0.873
OR 95% CI: 0.234-3.25
Binary weak
204.11 Lymphoid leukemia, acute
Acute lymphoblastic leukemia (childhood);Acute lymphoblastic leukemia (B-cell precursor);Acute lymphoblastic leukemia in childhood (B cell precursor)
MGI Fixed threshold (5e-06) GWAS Catalog (2019-05-03) 17 0.58 0.0059 0.0827 0.54
0.448-0.633
0
OR 95% CI: 0-0
Binary weak
153.3 Malignant neoplasm of rectum, rectosigmoid junction, and anus
Self-reported rectal cancer
MGI lassosum UKB GWAS (PHESANT) 183063 0.59 0.001 0.083 0.507
0.47-0.541
0.742
OR 95% CI: 0.201-2.73
Binary weak
155.1 Malignant neoplasm of liver, primary
MGI PRS-CS UKB GWAS (PheCode) 1119238 0.6 0.0022 0.0825 0.506
0.459-0.555
2.25
OR 95% CI: 0.672-7.54
Binary weak
159.3 Malignant neoplasm of gallbladder and extrahepatic bile ducts
MGI Fixed threshold (5e-06) UKB GWAS (PheCode) 8 0.6 0.0169 0.0826 0.483
0.417-0.549
0
OR 95% CI: 0-0
Binary weak
159.3 Malignant neoplasm of gallbladder and extrahepatic bile ducts
MGI lassosum UKB GWAS (PheCode) 177340 0.6 0.0285 0.0826 0.523
0.45-0.595
2.96
OR 95% CI: 0.66-13.3
Binary weak
165 Cancer within the respiratory system
Malignant neoplasm of respiratory system and intrathoracic organs
MGI Fixed threshold (5e-07) UKB GWAS (FINNGEN) 9 0.6 0.0006 0.0827 0.48
0.454-0.505
1.11
OR 95% CI: 0.453-2.71
Binary weak
184.11 Malignant neoplasm of ovary
Epithelial ovarian cancer;High-grade serous ovarian cancer;Serous invasive ovarian cancer;Invasive epithelial ovarian cancer;Mucinous ovarian carcinoma;Low-grade serous and serous borderline ovarian cancer;Serous borderline ovarian cancer;Ovarian cancer in BRCA1 mutation carriers;Ovarian cancer;Ovarian clear cell cancer
MGI P&T GWAS Catalog (2019-05-03) 10 0.6 0.0061 0.0829 0.505
0.459-0.549
0.799
OR 95% CI: 0.145-4.41
Binary weak
191.11 Cancer of brain
Self-reported brain cancer / primary malignant brain tumour
MGI lassosum UKB GWAS (PHESANT) 24094 0.6 0.0023 0.0826 0.509
0.474-0.55
3.13
OR 95% CI: 1.35-7.28
Binary weak
202 Cancer of other lymphoid, histiocytic tissue
Primary_lymphoid and hematopoietic malignant neoplasms
MGI Fixed threshold (5e-07) UKB GWAS (FINNGEN) 8 0.6 0.0001 0.0827 0.477
0.456-0.497
0.686
OR 95% CI: 0.261-1.8
Binary weak
209 Neuroendocrine tumors
Neuroblastoma;Neuroblastoma (high-risk);Sporadic neuroblastoma;Neuroblastoma (11q deletion)
MGI Fixed threshold (5e-09) GWAS Catalog (2019-05-03) 7 0.6 0.0006 0.0826 0.507
0.452-0.56
0
OR 95% CI: 0-0
Binary weak
209 Neuroendocrine tumors
Neuroblastoma;Neuroblastoma (high-risk);Sporadic neuroblastoma;Neuroblastoma (11q deletion)
MGI P&T GWAS Catalog (2019-05-03) 7 0.6 0.0006 0.0826 0.507
0.452-0.56
0
OR 95% CI: 0-0
Binary weak
153.3 Malignant neoplasm of rectum, rectosigmoid junction, and anus
Self-reported rectal cancer
MGI PRS-CS UKB GWAS (PHESANT) 1018916 0.61 0.0002 0.083 0.507
0.475-0.54
1.35
OR 95% CI: 0.494-3.67
Binary weak
204.1 Lymphoid leukemia
Lymphoid leukaemia
MGI Fixed threshold (5e-06) UKB GWAS (FINNGEN) 20 0.61 0.0037 0.0826 0.511
0.45-0.58
0
OR 95% CI: 0-0
Binary weak
151 Cancer of stomach
Self-reported stomach cancer
MGI PRS-CS UKB GWAS (PHESANT) 889207 0.62 0.0005 0.0829 0.507
0.463-0.546
1.55
OR 95% CI: 0.489-4.91
Binary weak
159 Malignant neoplasm of other and ill-defined sites within the digestive organs and peritoneum
Malignant neoplasm of digestive organs
MGI lassosum UKB GWAS (FINNGEN) 4 0.62 0.0015 0.0826 0.505
0.474-0.535
3.75
OR 95% CI: 2.02-6.95
Binary weak
159.3 Malignant neoplasm of gallbladder and extrahepatic bile ducts
MGI P&T UKB GWAS (PheCode) 114 0.62 0.0362 0.0826 0.502
0.43-0.573
1.89
OR 95% CI: 0.3-11.9
Binary weak
165.1 Cancer of bronchus; lung
ICD-10 C34 Malignant neoplasm of bronchus and lung
MGI P&T UKB GWAS (ICD10) 10 0.62 0.0027 0.0828 0.491
0.464-0.519
1.02
OR 95% CI: 0.38-2.72
Binary weak
159.2 Malignant neoplasm of small intestine, including duodenum
ICD-10 C17 Malignant neoplasm of small intestine
MGI Fixed threshold (5e-05) UKB GWAS (ICD10) 41 0.63 0 0.0826 0.507
0.446-0.568
1.73
OR 95% CI: 0.276-10.8
Binary weak
170 Cancer of bone and connective tissue
MGI Fixed threshold (5e-05) UKB GWAS (PheCode) 93 0.63 0 0.083 0.501
0.481-0.522
0.701
OR 95% CI: 0.293-1.68
Binary weak
202.2 Non-Hodgkin lymphoma
Diffuse large B cell lymphoma;Follicular lymphoma
MGI Fixed threshold (5e-06) GWAS Catalog (2019-05-03) 16 0.63 0.005 0.0827 0.494
0.471-0.519
1.58
OR 95% CI: 0.79-3.17
Binary weak
202.2 Non-Hodgkin lymphoma
Diffuse large B cell lymphoma;Follicular lymphoma
MGI Fixed threshold (5e-07) GWAS Catalog (2019-05-03) 16 0.63 0.005 0.0827 0.494
0.471-0.519
1.58
OR 95% CI: 0.79-3.17
Binary weak
202.2 Non-Hodgkin lymphoma
ICD-10 C83 Diffuse non-Hodgkin's lymphoma
MGI lassosum UKB GWAS (ICD10) 363554 0.63 0.0044 0.0827 0.502
0.476-0.528
1.26
OR 95% CI: 0.584-2.72
Binary weak
145.5 Cancer of the mouth floor
MGI PRS-CS UKB GWAS (PheCode) 1119238 0.64 0.0035 0.0826 0.515
0.441-0.586
2.65
OR 95% CI: 0.612-11.4
Binary weak
153.3 Malignant neoplasm of rectum, rectosigmoid junction, and anus
Diagnoses - main ICD10: C21 Malignant neoplasm of anus and anal canal (UKB GWAS (ICD10))
MGI P&T UKB GWAS (PheCode) 13 0.64 0.0017 0.083 0.498
0.466-0.531
2.28
OR 95% CI: 1.01-5.12
Binary weak
182 Malignant neoplasm of uterus
Malignant neoplasm of corpus uteri
MGI PRS-CS UKB GWAS (FINNGEN) 1104808 0.64 0.0001 0.0832 0.506
0.472-0.537
0.733
OR 95% CI: 0.199-2.7
Binary weak
184 Cancer of other female genital organs
malignant neoplasm of female genital organs
MGI Fixed threshold (5e-05) UKB GWAS (FINNGEN) 105 0.64 0.0004 0.0837 0.507
0.479-0.537
0.76
OR 95% CI: 0.253-2.29
Binary weak
202.2 Non-Hodgkin lymphoma
ICD-10 C83 Diffuse non-Hodgkin's lymphoma
MGI PRS-CS UKB GWAS (ICD10) 1087052 0.64 0.0026 0.0827 0.508
0.484-0.533
0.75
OR 95% CI: 0.285-1.98
Binary weak
202.24 Large cell lymphoma
MGI Fixed threshold (5e-06) UKB GWAS (PheCode) 11 0.64 0.0184 0.0832 0.505
0.442-0.572
1.98
OR 95% CI: 0.307-12.8
Binary weak
145.2 Cancer of tongue
Malignant neoplasm of other and unspecified parts of tongue (UKB GWAS (FINNGEN))
MGI lassosum UKB GWAS (PheCode) 4854389 0.65 0.0007 0.0828 0.513
0.474-0.55
0.939
OR 95% CI: 0.251-3.52
Binary weak
149.4 Cancer of larynx
ICD-10 C32 Malignant neoplasm of larynx
MGI Fixed threshold (5e-05) UKB GWAS (ICD10) 56 0.65 0.0002 0.0826 0.51
0.461-0.557
3.39
OR 95% CI: 1.24-9.26
Binary weak
149.9 Cancer of nasal cavities
Cancer of of nasal cavities
MGI Fixed threshold (5e-05) UKB GWAS (PheCode) 49 0.65 0 0.0828 0.5
0.434-0.56
1.55
OR 95% CI: 0.253-9.54
Binary weak
159.2 Malignant neoplasm of small intestine, including duodenum
ICD-10 C17 Malignant neoplasm of small intestine
MGI PRS-CS UKB GWAS (ICD10) 903170 0.65 0.0023 0.0826 0.509
0.44-0.581
1.79
OR 95% CI: 0.285-11.3
Binary weak
172.1 Melanomas of skin, dx or hx
ICD-10 D03 Melanoma in situ
MGI Fixed threshold (5e-05) UKB GWAS (ICD10) 95 0.65 0.0002 0.0969 0.498
0.482-0.516
0.87
OR 95% CI: 0.47-1.61
Binary weak
201 Hodgkin's disease
Hodgkin's lymphoma;Nodular sclerosis Hodgkin lymphoma
UKB Fixed threshold (5e-09) GWAS Catalog (2019-05-03) 10 0.65 0.0328 0.0821 0.504
0.453-0.56
1.88
OR 95% CI: 0.463-7.64
Binary weak
170.1 Bone cancer
Cancer code, self-reported: primary bone cancer (UKB GWAS (PHESANT))
MGI lassosum UKB GWAS (PheCode) 141650 0.66 0.0014 0.0829 0.515
0.483-0.548
0
OR 95% CI: 0-0
Binary weak
180 Cervical cancer and dysplasia
MGI lassosum UKB GWAS (PheCode) 80 0.66 0.0021 0.0909 0.476
0.453-0.498
1.1
OR 95% CI: 0.483-2.52
Binary weak
187.2 Malignant neoplasm of testis
Diagnoses - main ICD10: C62 Malignant neoplasm of testis (UKB GWAS (ICD10))
MGI Fixed threshold (5e-07) UKB GWAS (PheCode) 22 0.66 0.0019 0.0862 0.505
0.441-0.566
0
OR 95% CI: 0-0
Binary weak
204.2 Myeloid leukemia
Myeloid leukaemia
MGI Fixed threshold (5e-05) UKB GWAS (FINNGEN) 74 0.66 0.0003 0.0826 0.497
0.443-0.553
3.05
OR 95% CI: 0.856-10.8
Binary weak
165.1 Cancer of bronchus; lung
Lung cancer and mesothelioma
MGI Fixed threshold (5e-07) UKB GWAS (FINNGEN) 7 0.67 0.0002 0.0828 0.493
0.466-0.52
0.561
OR 95% CI: 0.155-2.04
Binary weak
165.1 Cancer of bronchus; lung
Lung cancer and mesothelioma
MGI Fixed threshold (5e-07) UKB GWAS (FINNGEN) 7 0.67 0.0002 0.0828 0.493
0.466-0.52
0.561
OR 95% CI: 0.155-2.04
Binary weak
184.11 Malignant neoplasm of ovary
Low-grade serous and serous borderline ovarian cancer
MGI GWAS Hits Phelan CM et al. 2017 10 0.67 0.0064 0.0829 0.517
0.467-0.562
0.802
OR 95% CI: 0.145-4.42
Binary weak
200 Myeloproliferative disease
MGI Fixed threshold (5e-06) UKB GWAS (PheCode) 19 0.67 0.0016 0.0826 0.491
0.465-0.517
1.47
OR 95% CI: 0.637-3.39
Binary weak
200 Myeloproliferative disease
MGI P&T UKB GWAS (PheCode) 25 0.67 0.0019 0.0826 0.493
0.466-0.519
1.24
OR 95% CI: 0.504-3.05
Binary weak
202 Cancer of other lymphoid, histiocytic tissue
Marginal zone lymphoma;Waldenström macroglobulinemia / lymphoplasmacytic lymphoma (GWAS Catalog (2019-05-03))
MGI Fixed threshold (5e-05) UKB GWAS (PheCode) 111 0.67 0 0.0827 0.502
0.479-0.526
0.987
OR 95% CI: 0.437-2.23
Binary weak
204 Leukemia
MGI Fixed threshold (5e-06) UKB GWAS (PheCode) 14 0.67 0.0007 0.0826 0.503
0.47-0.538
0.531
OR 95% CI: 0.1-2.81
Binary weak
180.1 Cervical cancer
Malignant neoplasm of cervix uteri
MGI Fixed threshold (5e-05) UKB GWAS (FINNGEN) 70 0.68 0.0013 0.0826 0.501
0.461-0.542
1.05
OR 95% CI: 0.276-3.98
Binary weak
182 Malignant neoplasm of uterus
Malignant neoplasm of corpus uteri
MGI Fixed threshold (5e-05) UKB GWAS (FINNGEN) 134 0.68 0.0002 0.0832 0.498
0.465-0.529
1.32
OR 95% CI: 0.484-3.59
Binary weak
189.2 Cancer of bladder
ICD-10 C67 Malignant neoplasm of bladder
MGI Fixed threshold (5e-06) UKB GWAS (ICD10) 28 0.68 0.0004 0.0923 0.497
0.476-0.517
0.43
OR 95% CI: 0.146-1.27
Binary weak
149 Cancer of larynx, pharynx, nasal cavities
MGI Fixed threshold (5e-06) UKB GWAS (PheCode) 11 0.69 0 0.0828 0.48
0.456-0.506
0.977
OR 95% CI: 0.403-2.37
Binary weak
149.1 Cancer of oropharynx
MGI Fixed threshold (5e-05) UKB GWAS (PheCode) 77 0.69 0.005 0.083 0.502
0.452-0.552
1.02
OR 95% CI: 0.181-5.75
Binary weak
149.1 Cancer of oropharynx
MGI P&T UKB GWAS (PheCode) 77 0.69 0.005 0.083 0.502
0.452-0.552
1.02
OR 95% CI: 0.181-5.75
Binary weak
155 Cancer of liver and intrahepatic bile duct
MGI lassosum UKB GWAS (PheCode) 1007258 0.69 0.0006 0.0826 0.506
0.467-0.547
2.62
OR 95% CI: 0.997-6.87
Binary weak
180.1 Cervical cancer
Cancer code, self-reported: cervical cancer (UKB GWAS (PHESANT))
MGI Fixed threshold (5e-06) UKB GWAS (PheCode) 12 0.69 0.0002 0.0826 0.491
0.454-0.53
1.04
OR 95% CI: 0.273-3.93
Binary weak
182 Malignant neoplasm of uterus
ICD-10 C54 Malignant neoplasm of corpus uteri
MGI Fixed threshold (5e-06) UKB GWAS (ICD10) 20 0.69 0.002 0.0832 0.493
0.461-0.524
1.64
OR 95% CI: 0.654-4.11
Binary weak
182 Malignant neoplasm of uterus
ICD-10 C54 Malignant neoplasm of corpus uteri
MGI P&T UKB GWAS (ICD10) 20 0.69 0.002 0.0832 0.493
0.461-0.524
1.64
OR 95% CI: 0.654-4.11
Binary weak
191.11 Cancer of brain
Self-reported brain cancer / primary malignant brain tumour
MGI Fixed threshold (5e-05) UKB GWAS (PHESANT) 47 0.69 0 0.0826 0.509
0.469-0.549
0
OR 95% CI: 0-0
Binary weak
204.4 Multiple myeloma
Self-reported multiple myeloma
MGI lassosum UKB GWAS (PHESANT) 37583 0.69 0.001 0.0827 0.518
0.455-0.578
0
OR 95% CI: 0-0
Binary weak
165.1 Cancer of bronchus; lung
Doctor diagnosed lung cancer (not mesothelioma)
MGI lassosum UKB GWAS (PHESANT) 97897 0.7 0.0006 0.0828 0.503
0.474-0.529
0.806
OR 95% CI: 0.268-2.43
Binary weak
170.2 Cancer of connective tissue
Self-reported sarcoma/fibrosarcoma
MGI Fixed threshold (5e-05) UKB GWAS (PHESANT) 50 0.7 0.0004 0.0828 0.496
0.471-0.522
1.91
OR 95% CI: 0.976-3.73
Binary weak
184.11 Malignant neoplasm of ovary
Mucinous ovarian carcinoma
MGI PRS-CS Phelan CM et al. 2017 1114056 0.7 0.0001 0.0829 0.507
0.462-0.553
1.3
OR 95% CI: 0.333-5.07
Binary weak
202.2 Non-Hodgkin lymphoma
Other and unspecified types of non-Hodgkin lymphoma
MGI lassosum UKB GWAS (FINNGEN) 1314 0.7 0.0004 0.0827 0.451
0.431-0.474
1.44
OR 95% CI: 0.693-2.97
Binary weak
204.4 Multiple myeloma
ICD-10 C90 Multiple myeloma and malignant plasma cell neoplasms
MGI lassosum UKB GWAS (ICD10) 68757 0.7 0.0025 0.0827 0.501
0.432-0.581
3.83
OR 95% CI: 1.04-14.1
Binary weak
150 Cancer of esophagus
Esophageal adenocarcinoma
MGI Fixed threshold (5e-05) GWAS Catalog (2019-05-03) 7 0.71 0.0003 0.0828 0.517
0.476-0.562
0.769
OR 95% CI: 0.14-4.21
Binary weak
150 Cancer of esophagus
Esophageal adenocarcinoma
MGI Fixed threshold (5e-06) GWAS Catalog (2019-05-03) 7 0.71 0.0003 0.0828 0.517
0.476-0.562
0.769
OR 95% CI: 0.14-4.21
Binary weak
150 Cancer of esophagus
Esophageal adenocarcinoma
MGI P&T GWAS Catalog (2019-05-03) 7 0.71 0.0003 0.0828 0.517
0.476-0.562
0.769
OR 95% CI: 0.14-4.21
Binary weak
182 Malignant neoplasm of uterus
Malignant neoplasm of corpus uteri
MGI Fixed threshold (5e-06) UKB GWAS (FINNGEN) 17 0.71 0.0001 0.0832 0.48
0.449-0.511
0.444
OR 95% CI: 0.0845-2.33
Binary weak
184.11 Malignant neoplasm of ovary
Low-grade serous ovarian cancer
MGI PRS-CS Phelan CM et al. 2017 1114046 0.71 0.0003 0.0829 0.51
0.467-0.558
2.38
OR 95% CI: 0.819-6.89
Binary weak
189.11 Malignant neoplasm of kidney, except pelvis
Malignant neoplasm of kidney, except renal pelvis
MGI P&T UKB GWAS (FINNGEN) 11 0.71 0.0005 0.0827 0.486
0.463-0.511
0.46
OR 95% CI: 0.128-1.65
Binary weak
201 Hodgkin's disease
Hodgkin lymphoma
MGI Fixed threshold (5e-06) UKB GWAS (FINNGEN) 10 0.71 0.0001 0.0831 0.508
0.443-0.573
0
OR 95% CI: 0-0
Binary weak
202.2 Non-Hodgkin lymphoma
ICD-10 C85 Other and unspecified types of non-Hodgkin's lymphoma
MGI lassosum UKB GWAS (ICD10) 48 0.71 0.0042 0.0827 0.488
0.465-0.512
0.753
OR 95% CI: 0.286-1.98
Binary weak
149.9 Cancer of nasal cavities
Cancer of of nasal cavities
MGI P&T UKB GWAS (PheCode) 6 0.72 0.0024 0.0829 0.486
0.424-0.552
0
OR 95% CI: 0-0
Binary weak
153.3 Malignant neoplasm of rectum, rectosigmoid junction, and anus
Malignant neoplasm of rectum
MGI Fixed threshold (5e-05) UKB GWAS (FINNGEN) 155 0.72 0.0002 0.083 0.504
0.475-0.537
0.434
OR 95% CI: 0.0827-2.28
Binary weak
165 Cancer within the respiratory system
Malignant neoplasm of respiratory system and intrathoracic organs
MGI Fixed threshold (5e-06) UKB GWAS (FINNGEN) 27 0.72 0 0.0827 0.492
0.465-0.518
0.511
OR 95% CI: 0.141-1.85
Binary weak
170.2 Cancer of connective tissue
Melignant neoplasm of mesothelium and soft tissue
MGI Fixed threshold (5e-05) UKB GWAS (FINNGEN) 83 0.72 0.0005 0.0828 0.499
0.473-0.524
0.803
OR 95% CI: 0.304-2.12
Binary weak
184.11 Malignant neoplasm of ovary
Mucinous ovarian carcinoma
MGI P&T Phelan CM et al. 2017 254 0.72 0.0054 0.0829 0.509
0.463-0.554
1.84
OR 95% CI: 0.564-5.98
Binary weak
189.1 Cancer of kidney and renal pelvis
MGI PRS-CS UKB GWAS (PheCode) 1119238 0.72 0.0002 0.0827 0.503
0.479-0.526
0.692
OR 95% CI: 0.264-1.82
Binary weak
149.4 Cancer of larynx
Diagnoses - main ICD10: C32 Malignant neoplasm of larynx (UKB GWAS (ICD10))
MGI PRS-CS UKB GWAS (PheCode) 1119238 0.73 0.0002 0.0826 0.508
0.464-0.556
0
OR 95% CI: 0-0
Binary weak
172.3 Carcinoma in situ of skin
ICD-10 D04 Carcinoma in situ of skin
MGI Fixed threshold (5e-05) UKB GWAS (ICD10) 92 0.73 0.0011 0.094 0.498
0.475-0.522
0.768
OR 95% CI: 0.289-2.05
Binary weak
180.1 Cervical cancer
Malignant neoplasm of cervix uteri
MGI Fixed threshold (5e-06) UKB GWAS (FINNGEN) 9 0.73 0.0014 0.0826 0.491
0.45-0.529
1.07
OR 95% CI: 0.282-4.06
Binary weak
202.21 Nodular lymphoma
MGI lassosum UKB GWAS (PheCode) 6090866 0.73 0.0009 0.0826 0.502
0.468-0.536
0.819
OR 95% CI: 0.221-3.04
Binary weak
153.2 Colon cancer
Malignant neoplasm of colon
MGI Fixed threshold (5e-05) UKB GWAS (FINNGEN) 136 0.74 0.0007 0.0833 0.507
0.481-0.536
0.313
OR 95% CI: 0.0606-1.61
Binary weak
153.3 Malignant neoplasm of rectum, rectosigmoid junction, and anus
Malignant neoplasm of anus and anal canal
MGI Fixed threshold (5e-05) UKB GWAS (FINNGEN) 70 0.74 0.0007 0.083 0.496
0.465-0.53
1.34
OR 95% CI: 0.491-3.64
Binary weak
180.1 Cervical cancer
Malignant neoplasm of cervix uteri
MGI PRS-CS UKB GWAS (FINNGEN) 1049464 0.74 0.0019 0.0826 0.501
0.46-0.543
1.48
OR 95% CI: 0.469-4.69
Binary weak
184.11 Malignant neoplasm of ovary
Endometrioid ovarian cancer
UKB Fixed threshold (5e-05) Phelan CM et al. 2017 98 0.74 0 0.0827 0.508
0.483-0.533
0.716
OR 95% CI: 0.239-2.15
Binary weak
150 Cancer of esophagus
Esophageal adenocarcinoma (GWAS Catalog (2019-05-03))
MGI Fixed threshold (5e-06) UKB GWAS (PheCode) 7 0.75 0.0002 0.0828 0.462
0.425-0.502
1.79
OR 95% CI: 0.556-5.78
Binary weak
170.2 Cancer of connective tissue
Malignant neoplasm of other connective and soft tissue
MGI Fixed threshold (5e-05) UKB GWAS (FINNGEN) 74 0.75 0.0002 0.0828 0.499
0.473-0.523
1.16
OR 95% CI: 0.511-2.65
Binary weak
184.11 Malignant neoplasm of ovary
Epithelial ovarian cancer
MGI Fixed threshold (5e-09) Phelan CM et al. 2017 5 0.75 0.0077 0.0829 0.504
0.46-0.551
1.9
OR 95% CI: 0.582-6.23
Binary weak
184.11 Malignant neoplasm of ovary
Epithelial ovarian cancer
MGI P&T Phelan CM et al. 2017 5 0.75 0.0077 0.0829 0.504
0.46-0.551
1.9
OR 95% CI: 0.582-6.23
Binary weak
184.11 Malignant neoplasm of ovary
Low-grade serous ovarian cancer
UKB P&T Phelan CM et al. 2017 29 0.75 0.0007 0.0827 0.503
0.475-0.531
0.924
OR 95% CI: 0.348-2.46
Binary weak
189.11 Malignant neoplasm of kidney, except pelvis
Malignant neoplasm of kidney, except renal pelvis
MGI Fixed threshold (5e-06) UKB GWAS (FINNGEN) 21 0.75 0.0001 0.0827 0.494
0.471-0.519
1.4
OR 95% CI: 0.645-3.03
Binary weak
190 Cancer of eye
Self-reported eye and/or adnexal cancer
MGI Fixed threshold (5e-05) UKB GWAS (PHESANT) 34 0.75 0.0073 0.0837 0.492
0.414-0.565
3.29
OR 95% CI: 0.71-15.3
Binary weak
149.4 Cancer of larynx
ICD-10 C32 Malignant neoplasm of larynx
MGI Fixed threshold (5e-06) UKB GWAS (ICD10) 15 0.77 0.0001 0.0826 0.501
0.451-0.55
2.12
OR 95% CI: 0.642-7
Binary weak
155.1 Malignant neoplasm of liver, primary
MGI lassosum UKB GWAS (PheCode) 6162796 0.77 0.002 0.0826 0.498
0.452-0.548
2.24
OR 95% CI: 0.672-7.44
Binary weak
190 Cancer of eye
Malignant neoplasm of eye and adnexa
MGI Fixed threshold (5e-05) UKB GWAS (FINNGEN) 49 0.77 0.007 0.0837 0.501
0.425-0.577
1.93
OR 95% CI: 0.299-12.4
Binary weak
190 Cancer of eye
Malignant neoplasm of eye and adnexa
MGI P&T UKB GWAS (FINNGEN) 49 0.77 0.007 0.0837 0.501
0.425-0.577
1.93
OR 95% CI: 0.299-12.4
Binary weak
149.4 Cancer of larynx
Self-reported larynx/throat cancer
MGI Fixed threshold (5e-06) UKB GWAS (PHESANT) 11 0.78 0.0013 0.0826 0.493
0.447-0.54
2.12
OR 95% CI: 0.645-6.97
Binary weak
184.11 Malignant neoplasm of ovary
Epithelial ovarian cancer
MGI GWAS Hits Phelan CM et al. 2017 6 0.79 0.0037 0.0829 0.506
0.461-0.551
1.87
OR 95% CI: 0.571-6.13
Binary weak
184.11 Malignant neoplasm of ovary
Low-grade serous and serous borderline ovarian cancer
UKB Fixed threshold (5e-05) Phelan CM et al. 2017 146 0.79 0.0016 0.0827 0.51
0.483-0.538
0.717
OR 95% CI: 0.239-2.15
Binary weak
191.11 Cancer of brain
Self-reported brain cancer / primary malignant brain tumour
MGI Fixed threshold (5e-06) UKB GWAS (PHESANT) 7 0.79 0.0001 0.0826 0.503
0.461-0.542
0.978
OR 95% CI: 0.258-3.7
Binary weak
202.2 Non-Hodgkin lymphoma
ICD-10 C85 Other and unspecified types of non-Hodgkin's lymphoma
MGI P&T UKB GWAS (ICD10) 38 0.79 0.0062 0.0827 0.492
0.469-0.516
1.26
OR 95% CI: 0.585-2.72
Binary weak
150 Cancer of esophagus
Esophageal adenocarcinoma (GWAS Catalog (2019-05-03))
MGI P&T UKB GWAS (PheCode) 45 0.8 0.0022 0.0828 0.504
0.465-0.548
1.27
OR 95% CI: 0.329-4.92
Binary weak
153.3 Malignant neoplasm of rectum, rectosigmoid junction, and anus
ICD-10 C20 Malignant neoplasm of rectum
MGI P&T UKB GWAS (ICD10) 16 0.8 0.0008 0.083 0.488
0.457-0.521
1.04
OR 95% CI: 0.34-3.19
Binary weak
187.2 Malignant neoplasm of testis
Diagnoses - main ICD10: C62 Malignant neoplasm of testis (UKB GWAS (ICD10))
MGI P&T UKB GWAS (PheCode) 48 0.8 0.0043 0.0862 0.512
0.447-0.574
0
OR 95% CI: 0-0
Binary weak
150 Cancer of esophagus
Esophageal adenocarcinoma
UKB Fixed threshold (5e-05) GWAS Catalog (2019-05-03) 7 0.81 0.0009 0.0826 0.503
0.472-0.532
3.33
OR 95% CI: 1.78-6.25
Binary weak
150 Cancer of esophagus
Esophageal adenocarcinoma
UKB Fixed threshold (5e-06) GWAS Catalog (2019-05-03) 7 0.81 0.0009 0.0826 0.503
0.472-0.532
3.33
OR 95% CI: 1.78-6.25
Binary weak
150 Cancer of esophagus
Esophageal adenocarcinoma
UKB P&T GWAS Catalog (2019-05-03) 7 0.81 0.0009 0.0826 0.503
0.472-0.532
3.33
OR 95% CI: 1.78-6.25
Binary weak
184 Cancer of other female genital organs
malignant neoplasm of female genital organs
MGI PRS-CS UKB GWAS (FINNGEN) 1111495 0.81 0 0.0837 0.507
0.479-0.533
0.545
OR 95% CI: 0.15-1.97
Binary weak
194 Cancer of other endocrine glands
Malignant neoplasm of endocrine gland
MGI Fixed threshold (5e-06) UKB GWAS (FINNGEN) 19 0.81 0.0005 0.0828 0.497
0.445-0.553
1.31
OR 95% CI: 0.222-7.69
Binary weak
194 Cancer of other endocrine glands
Malignant neoplasm of endocrine gland
MGI Fixed threshold (5e-07) UKB GWAS (FINNGEN) 5 0.81 0.001 0.0828 0.487
0.434-0.538
1.29
OR 95% CI: 0.219-7.63
Binary weak
204.1 Lymphoid leukemia
MGI lassosum UKB GWAS (PheCode) 14079 0.81 0.0119 0.0826 0.502
0.432-0.566
2.68
OR 95% CI: 0.615-11.7
Binary weak
204.4 Multiple myeloma
Multiple myeloma (hyperdiploidy);Multiple myeloma (IgH translocation);Multiple myeloma;Multiple myeloma and monoclonal gammopathy (GWAS Catalog (2019-05-03))
MGI Fixed threshold (5e-06) UKB GWAS (PheCode) 10 0.81 0.0046 0.0827 0.499
0.439-0.56
0
OR 95% CI: 0-0
Binary weak
204.4 Multiple myeloma
Multiple myeloma (hyperdiploidy);Multiple myeloma (IgH translocation);Multiple myeloma;Multiple myeloma and monoclonal gammopathy (GWAS Catalog (2019-05-03))
MGI P&T UKB GWAS (PheCode) 10 0.81 0.0046 0.0827 0.499
0.439-0.56
0
OR 95% CI: 0-0
Binary weak
165.1 Cancer of bronchus; lung
Doctor diagnosed lung cancer (not mesothelioma)
MGI Fixed threshold (5e-06) UKB GWAS (PHESANT) 5 0.82 0.003 0.0828 0.497
0.47-0.524
0
OR 95% CI: 0-0
Binary weak
165.1 Cancer of bronchus; lung
Doctor diagnosed lung cancer (not mesothelioma)
MGI P&T UKB GWAS (PHESANT) 5 0.82 0.003 0.0828 0.497
0.47-0.524
0
OR 95% CI: 0-0
Binary weak
182 Malignant neoplasm of uterus
Endometrial cancer;Endometrial cancer (endometrioid histology);Endometrial endometrioid carcinoma;Endometrial cancer (Non-endometrioid histology) (GWAS Catalog (2019-05-03))
MGI P&T UKB GWAS (PheCode) 28 0.82 0.0043 0.0832 0.49
0.458-0.522
0.729
OR 95% CI: 0.198-2.69
Binary weak
184.11 Malignant neoplasm of ovary
Low-grade serous and serous borderline ovarian cancer
MGI Fixed threshold (5e-07) Phelan CM et al. 2017 13 0.82 0.0047 0.0829 0.511
0.462-0.556
0.804
OR 95% CI: 0.146-4.43
Binary weak
189.1 Cancer of kidney and renal pelvis
MGI Fixed threshold (5e-05) UKB GWAS (PheCode) 83 0.82 0.0003 0.0827 0.495
0.473-0.517
0.868
OR 95% CI: 0.36-2.09
Binary weak
191.11 Cancer of brain
Malignant neoplasm of brain
MGI Fixed threshold (5e-06) UKB GWAS (FINNGEN) 16 0.82 0.0001 0.0826 0.498
0.461-0.536
0
OR 95% CI: 0-0
Binary weak
202.21 Nodular lymphoma
Follicular lymphoma
MGI P&T UKB GWAS (FINNGEN) 169 0.82 0.0007 0.0826 0.491
0.458-0.525
2.15
OR 95% CI: 0.906-5.11
Binary weak
204.1 Lymphoid leukemia
ICD-10 C91 Lymphoid leukaemia
MGI Fixed threshold (5e-05) UKB GWAS (ICD10) 91 0.82 0 0.0826 0.495
0.434-0.552
2.64
OR 95% CI: 0.604-11.5
Binary weak
157 Pancreatic cancer
ICD-10 C25 Malignant neoplasm of pancreas
MGI Fixed threshold (5e-06) UKB GWAS (ICD10) 17 0.83 0 0.0829 0.492
0.448-0.533
1.04
OR 95% CI: 0.273-3.99
Binary weak
189.11 Malignant neoplasm of kidney, except pelvis
Malignant neoplasm of kidney, except renal pelvis
MGI lassosum UKB GWAS (FINNGEN) 37 0.83 0.0012 0.0827 0.503
0.482-0.53
1.17
OR 95% CI: 0.515-2.68
Binary weak
201 Hodgkin's disease
Diagnoses - main ICD10: C81 Hodgkin's disease (UKB GWAS (ICD10))
MGI P&T UKB GWAS (PheCode) 17 0.83 0.0076 0.0831 0.477
0.402-0.546
1.71
OR 95% CI: 0.27-10.8
Binary weak
145 Cancer of mouth
Malignant neoplasm of tonsil
MGI Fixed threshold (5e-05) UKB GWAS (FINNGEN) 56 0.84 0.0001 0.083 0.499
0.475-0.525
0.759
OR 95% CI: 0.288-2
Binary weak
153.3 Malignant neoplasm of rectum, rectosigmoid junction, and anus
Malignant neoplasm of rectum
MGI P&T UKB GWAS (FINNGEN) 110 0.84 0.0008 0.083 0.5
0.47-0.533
1.03
OR 95% CI: 0.337-3.16
Binary weak
184.11 Malignant neoplasm of ovary
Low-grade serous and serous borderline ovarian cancer
MGI Fixed threshold (5e-06) Phelan CM et al. 2017 28 0.84 0.0076 0.0829 0.51
0.466-0.555
0
OR 95% CI: 0-0
Binary weak
150 Cancer of esophagus
Esophageal adenocarcinoma (GWAS Catalog (2019-05-03))
MGI lassosum UKB GWAS (PheCode) 64075 0.85 0.0025 0.0828 0.502
0.457-0.546
2.31
OR 95% CI: 0.803-6.66
Binary weak
153.2 Colon cancer
Self-reported colon cancer/sigmoid cancer
MGI Fixed threshold (5e-06) UKB GWAS (PHESANT) 18 0.85 0.0003 0.0833 0.486
0.46-0.512
0.514
OR 95% CI: 0.142-1.86
Binary weak
145.2 Cancer of tongue
Self-reported tongue cancer
MGI PRS-CS UKB GWAS (PHESANT) 868459 0.86 0.0004 0.0828 0.502
0.468-0.54
0
OR 95% CI: 0-0
Binary weak
149.1 Cancer of oropharynx
MGI PRS-CS UKB GWAS (PheCode) 1119238 0.86 0.0004 0.083 0.508
0.457-0.558
1.71
OR 95% CI: 0.427-6.85
Binary weak
149.4 Cancer of larynx
Self-reported larynx/throat cancer
MGI Fixed threshold (5e-05) UKB GWAS (PHESANT) 72 0.87 0.0011 0.0826 0.506
0.464-0.552
1.51
OR 95% CI: 0.383-5.95
Binary weak
153.2 Colon cancer
Self-reported colon cancer/sigmoid cancer
MGI Fixed threshold (5e-05) UKB GWAS (PHESANT) 138 0.87 0.0001 0.0833 0.496
0.47-0.525
0.729
OR 95% CI: 0.243-2.19
Binary weak
155 Cancer of liver and intrahepatic bile duct
MGI PRS-CS UKB GWAS (PheCode) 1119238 0.87 0.0002 0.0826 0.504
0.458-0.548
1.6
OR 95% CI: 0.499-5.1
Binary weak
159.2 Malignant neoplasm of small intestine, including duodenum
MGI PRS-CS UKB GWAS (PheCode) 1119238 0.87 0 0.0826 0.493
0.428-0.561
2.96
OR 95% CI: 0.656-13.4
Binary weak
170.2 Cancer of connective tissue
Self-reported sarcoma/fibrosarcoma
MGI P&T UKB GWAS (PHESANT) 61 0.87 0.0005 0.0828 0.495
0.47-0.522
1.72
OR 95% CI: 0.853-3.45
Binary weak
180.1 Cervical cancer
ICD-10 C53 Malignant neoplasm of cervix uteri
MGI PRS-CS UKB GWAS (ICD10) 978092 0.87 0.0017 0.0826 0.502
0.465-0.539
1.06
OR 95% CI: 0.278-4.01
Binary weak
190 Cancer of eye
Malignant neoplasm of eye and adnexa (UKB GWAS (FINNGEN))
MGI Fixed threshold (5e-05) UKB GWAS (PheCode) 71 0.88 0.001 0.0837 0.486
0.403-0.56
0
OR 95% CI: 0-0
Binary weak
204.1 Lymphoid leukemia
ICD-10 C91 Lymphoid leukaemia
MGI lassosum UKB GWAS (ICD10) 11436 0.88 0.0046 0.0826 0.504
0.445-0.565
1.58
OR 95% CI: 0.259-9.59
Binary weak
204.12 Lymphoid leukemia, chronic
Self-reported chronic lymphocytic
MGI lassosum UKB GWAS (PHESANT) 3533 0.88 0.0074 0.0829 0.498
0.423-0.565
0
OR 95% CI: 0-0
Binary weak
150 Cancer of esophagus
Self-reported oesophageal cancer
MGI Fixed threshold (5e-05) UKB GWAS (PHESANT) 60 0.89 0.0011 0.0828 0.502
0.46-0.543
0
OR 95% CI: 0-0
Binary weak
151 Cancer of stomach
Self-reported stomach cancer
MGI P&T UKB GWAS (PHESANT) 6 0.89 0.0011 0.0829 0.504
0.459-0.544
0
OR 95% CI: 0-0
Binary weak
184.11 Malignant neoplasm of ovary
Mucinous ovarian carcinoma
UKB Fixed threshold (5e-06) Phelan CM et al. 2017 27 0.89 0.0034 0.0827 0.503
0.477-0.528
1.76
OR 95% CI: 0.839-3.7
Binary weak
189.11 Malignant neoplasm of kidney, except pelvis
ICD-10 C64 Malignant neoplasm of kidney, except renal pelvis
MGI Fixed threshold (5e-06) UKB GWAS (ICD10) 24 0.89 0.0003 0.0827 0.486
0.462-0.515
1.56
OR 95% CI: 0.75-3.25
Binary weak
189.11 Malignant neoplasm of kidney, except pelvis
ICD-10 C64 Malignant neoplasm of kidney, except renal pelvis
MGI P&T UKB GWAS (ICD10) 24 0.89 0.0003 0.0827 0.486
0.462-0.515
1.56
OR 95% CI: 0.75-3.25
Binary weak
200.1 Polycythemia vera
MGI Fixed threshold (5e-05) UKB GWAS (PheCode) 95 0.89 0.0012 0.0826 0.501
0.436-0.567
0
OR 95% CI: 0-0
Binary weak
200.1 Polycythemia vera
MGI P&T UKB GWAS (PheCode) 95 0.89 0.0012 0.0826 0.501
0.436-0.567
0
OR 95% CI: 0-0
Binary weak
202.21 Nodular lymphoma
ICD-10 C82 Follicular [nodular] non-Hodgkin's lymphoma
MGI PRS-CS UKB GWAS (ICD10) 1047514 0.89 0 0.0826 0.502
0.467-0.536
0.814
OR 95% CI: 0.219-3.02
Binary weak
153.3 Malignant neoplasm of rectum, rectosigmoid junction, and anus
Malignant neoplasm of rectosigmoid junction
MGI P&T UKB GWAS (FINNGEN) 21 0.9 0.0008 0.083 0.493
0.462-0.526
0.731
OR 95% CI: 0.199-2.69
Binary weak
155 Cancer of liver and intrahepatic bile duct
ICD-10 C22 Malignant neoplasm of liver and intrahepatic bile ducts
MGI Fixed threshold (5e-06) UKB GWAS (ICD10) 11 0.9 0.0008 0.0826 0.493
0.451-0.535
0.696
OR 95% CI: 0.128-3.77
Binary weak
157 Pancreatic cancer
GWAS Catalog (2019-05-03)
MGI P&T UKB GWAS (PheCode) 18 0.9 0.0013 0.0829 0.49
0.449-0.531
1.09
OR 95% CI: 0.288-4.16
Binary weak
172.22 Squamous cell carcinoma
Self-reported squamous cell carcinoma
MGI Fixed threshold (5e-06) UKB GWAS (PHESANT) 19 0.9 0.0001 0.0998 0.49
0.471-0.508
1.22
OR 95% CI: 0.66-2.25
Binary weak
204 Leukemia
Self-reported leukaemia
MGI PRS-CS UKB GWAS (PHESANT) 943472 0.9 0.0015 0.0826 0.501
0.467-0.537
0.876
OR 95% CI: 0.235-3.26
Binary weak
145 Cancer of mouth
MGI Fixed threshold (5e-06) UKB GWAS (PheCode) 11 0.91 0.0001 0.083 0.482
0.459-0.507
0.943
OR 95% CI: 0.389-2.28
Binary weak
159.2 Malignant neoplasm of small intestine, including duodenum
MGI P&T UKB GWAS (PheCode) 73 0.91 0.0049 0.0826 0.504
0.432-0.577
1.73
OR 95% CI: 0.273-11
Binary weak
159.4 Malignant neoplasm of retroperitoneum and peritoneum
Diagnoses - main ICD10: C48 Malignant neoplasm of retroperitoneum and peritoneum (UKB GWAS (ICD10))
MGI PRS-CS UKB GWAS (PheCode) 1119238 0.91 0.0001 0.0826 0.513
0.454-0.568
0
OR 95% CI: 0-0
Binary weak
202 Cancer of other lymphoid, histiocytic tissue
Mature T/NK-cell lymphomas
MGI P&T UKB GWAS (FINNGEN) 80 0.91 0.001 0.0827 0.498
0.474-0.52
1.13
OR 95% CI: 0.527-2.43
Binary weak
204.11 Lymphoid leukemia, acute
Acute lymphoblastic leukemia (childhood);Acute lymphoblastic leukemia (B-cell precursor);Acute lymphoblastic leukemia in childhood (B cell precursor)
UKB Fixed threshold (5e-09) GWAS Catalog (2019-05-03) 5 0.91 0.0014 0.0828 0.476
0.355-0.605
0
OR 95% CI: 0-0
Binary weak
145.2 Cancer of tongue
Malignant neoplasm of other and unspecified parts of tongue
MGI Fixed threshold (5e-05) UKB GWAS (FINNGEN) 49 0.92 0.0007 0.0828 0.501
0.465-0.54
0.556
OR 95% CI: 0.105-2.96
Binary weak
159.2 Malignant neoplasm of small intestine, including duodenum
MGI Fixed threshold (5e-05) UKB GWAS (PheCode) 90 0.92 0.004 0.0826 0.503
0.435-0.574
1.71
OR 95% CI: 0.27-10.8
Binary weak
159.2 Malignant neoplasm of small intestine, including duodenum
Malignant neoplasm of small intestine
MGI lassosum UKB GWAS (FINNGEN) 2552539 0.92 0.0069 0.0826 0.504
0.442-0.569
0
OR 95% CI: 0-0
Binary weak
170.1 Bone cancer
Self-reported primary bone cancer
MGI lassosum UKB GWAS (PHESANT) 2805117 0.92 0.0029 0.0829 0.498
0.466-0.53
1.3
OR 95% CI: 0.477-3.52
Binary weak
184.11 Malignant neoplasm of ovary
High-grade serous ovarian cancer
UKB PRS-CS Phelan CM et al. 2017 1115189 0.92 0.0003 0.0827 0.503
0.475-0.532
1.13
OR 95% CI: 0.464-2.77
Binary weak
204 Leukemia
Self-reported leukaemia
MGI lassosum UKB GWAS (PHESANT) 349179 0.92 0.0014 0.0826 0.505
0.469-0.541
1.25
OR 95% CI: 0.401-3.86
Binary weak
153.3 Malignant neoplasm of rectum, rectosigmoid junction, and anus
ICD-10 C20 Malignant neoplasm of rectum
MGI Fixed threshold (5e-06) UKB GWAS (ICD10) 19 0.93 0.0005 0.083 0.49
0.459-0.522
1.05
OR 95% CI: 0.343-3.22
Binary weak
190 Cancer of eye
Malignant neoplasm of eye and adnexa
MGI Fixed threshold (5e-06) UKB GWAS (FINNGEN) 7 0.93 0.0021 0.0837 0.496
0.417-0.571
1.86
OR 95% CI: 0.286-12.1
Binary weak
204.2 Myeloid leukemia
Myeloid leukaemia
MGI Fixed threshold (5e-06) UKB GWAS (FINNGEN) 8 0.93 0.0077 0.0826 0.5
0.445-0.549
1.28
OR 95% CI: 0.217-7.59
Binary weak
145 Cancer of mouth
Malignant neoplasm of tonsil
MGI PRS-CS UKB GWAS (FINNGEN) 950488 0.94 0.0006 0.083 0.501
0.476-0.526
0.935
OR 95% CI: 0.386-2.26
Binary weak
153.3 Malignant neoplasm of rectum, rectosigmoid junction, and anus
ICD-10 C21 Malignant neoplasm of anus and anal canal
MGI Fixed threshold (5e-07) UKB GWAS (ICD10) 8 0.94 0.0018 0.083 0.484
0.452-0.518
1.04
OR 95% CI: 0.341-3.2
Binary weak
184.11 Malignant neoplasm of ovary
Epithelial ovarian cancer
MGI Fixed threshold (5e-07) Phelan CM et al. 2017 7 0.94 0.0009 0.0829 0.5
0.456-0.548
1.33
OR 95% CI: 0.343-5.18
Binary weak
184.11 Malignant neoplasm of ovary
ICD-10 C56 Malignant neoplasm of ovary
MGI lassosum UKB GWAS (ICD10) 49464 0.94 0.0009 0.0829 0.499
0.457-0.54
0.82
OR 95% CI: 0.148-4.54
Binary weak
149.1 Cancer of oropharynx
ICD-10 C09 Malignant neoplasm of tonsil
MGI lassosum UKB GWAS (ICD10) 41255 0.95 0.0016 0.083 0.497
0.447-0.546
2.48
OR 95% CI: 0.735-8.36
Binary weak
170.2 Cancer of connective tissue
Malignant neoplasm of other connective and soft tissue
MGI P&T UKB GWAS (FINNGEN) 12 0.95 0.0014 0.0828 0.49
0.464-0.516
2.09
OR 95% CI: 1.1-3.99
Binary weak
145.3 Cancer of major salivary glands
MGI Fixed threshold (5e-05) UKB GWAS (PheCode) 81 0.96 0.0006 0.0826 0.494
0.448-0.544
0.861
OR 95% CI: 0.155-4.77
Binary weak
159.4 Malignant neoplasm of retroperitoneum and peritoneum
Diagnoses - main ICD10: C48 Malignant neoplasm of retroperitoneum and peritoneum (UKB GWAS (ICD10))
MGI Fixed threshold (5e-06) UKB GWAS (PheCode) 9 0.96 0.0006 0.0826 0.466
0.415-0.515
1.06
OR 95% CI: 0.185-6.12
Binary weak
184.11 Malignant neoplasm of ovary
Epithelial ovarian cancer
UKB Fixed threshold (5e-05) Phelan CM et al. 2017 111 0.96 0.003 0.0827 0.5
0.472-0.529
1.13
OR 95% CI: 0.463-2.76
Binary weak
204.21 Myeloid leukemia, acute
MGI P&T UKB GWAS (PheCode) 23 0.96 0.0148 0.0826 0.487
0.415-0.554
0
OR 95% CI: 0-0
Binary weak
204.21 Myeloid leukemia, acute
MGI lassosum UKB GWAS (PheCode) 40976 0.96 0.0147 0.0826 0.502
0.431-0.565
1.89
OR 95% CI: 0.292-12.3
Binary weak
159.2 Malignant neoplasm of small intestine, including duodenum
Malignant neoplasm of small intestine
MGI Fixed threshold (5e-05) UKB GWAS (FINNGEN) 51 0.97 0.0001 0.0827 0.508
0.44-0.577
0
OR 95% CI: 0-0
Binary weak
170.2 Cancer of connective tissue
Malignant neoplasm of other connective and soft tissue
MGI Fixed threshold (5e-06) UKB GWAS (FINNGEN) 11 0.97 0.0008 0.0828 0.49
0.464-0.516
1.35
OR 95% CI: 0.625-2.93
Binary weak
170.2 Cancer of connective tissue
ICD-10 C49 Malignant neoplasm of other connective and soft tissue
MGI PRS-CS UKB GWAS (ICD10) 1002162 0.97 0 0.0828 0.504
0.48-0.53
0.448
OR 95% CI: 0.125-1.61
Binary weak
180.1 Cervical cancer
Self-reported cervical cancer
MGI PRS-CS UKB GWAS (PHESANT) 1107375 0.97 0.0001 0.0826 0.502
0.466-0.541
1.46
OR 95% CI: 0.46-4.6
Binary weak
165 Cancer within the respiratory system
Mesothelioma
MGI P&T UKB GWAS (FINNGEN) 18 0.98 0.0005 0.0827 0.497
0.47-0.526
1.34
OR 95% CI: 0.582-3.07
Binary weak
153.2 Colon cancer
ICD-10 C18 Malignant neoplasm of colon
MGI Fixed threshold (5e-05) UKB GWAS (ICD10) 144 0.99 0 0.0833 0.497
0.47-0.525
1.61
OR 95% CI: 0.736-3.53
Binary weak
180.3 Cervical intraepithelial neoplasia [CIN] [Cervical dysplasia]
Cancer code, self-reported: cin/pre-cancer cells cervix (UKB GWAS (PHESANT))
MGI lassosum UKB GWAS (PheCode) 38 0.99 0.0038 0.0886 0.519
0.49-0.549
0.334
OR 95% CI: 0.0641-1.74
Binary weak
204.11 Lymphoid leukemia, acute
Acute lymphoblastic leukemia (childhood);Acute lymphoblastic leukemia (B-cell precursor);Acute lymphoblastic leukemia in childhood (B cell precursor) (GWAS Catalog (2019-05-03))
MGI Fixed threshold (5e-06) UKB GWAS (PheCode) 7 0.99 0.0072 0.0827 0.482
0.382-0.578
0
OR 95% CI: 0-0
Binary weak
204.2 Myeloid leukemia
Myeloid leukaemia
MGI PRS-CS UKB GWAS (FINNGEN) 1034666 1 0.0003 0.0826 0.505
0.448-0.557
0
OR 95% CI: 0-0
Binary weak
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