Cancer PRSweb

Polygenic risk scores

Scores Evaluation trait 153 UK Biobank

Colorectal cancer

Supplementary Tables 11 & 15; Cases: Discovery: 34,869; Follow-up: 23,262; Controls: Discovery: 29,051; Follow-up: 38,296 controls

Binary UKB P&T Huyghe JR et al. 2019 nominally significant

This PRS has a linked catalog record and a separate weight-file download.

Model details

PRS IDprsweb-phecode153-crc-huyghe-pt-ukb-20200608
Legacy IDPRSWEB_PHECODE153_CRC-Huyghe_PT_UKB_20200608
Legacy modelP&T
# SNPs87
Catalog record ID PGS000370
Discovery GWAS trait/source Huyghe JR et al. 2019
Genome buildGRCh37/hg19
Tuning parameterP<=7.8e-06
Reference Publication PubMed 30510241
Last updated2020-06-08

Evaluation details

Evaluation cohortUK Biobank
Evaluation trait Colorectal cancer
153
Trait typeBinary
SexBoth
Cases2271
Controls22725

PRS performance

P value4.5e-83
Pseudo-R²0.034
Brier score0.081
AAUC0.617
AAUC CI0.605-0.630
Percentile effect metricOR
Top percentile OR 95% CI
1%4.003.11-5.13
2%3.402.80-4.11
5%2.692.34-3.08
10%2.352.11-2.63
25%1.991.82-2.18

How to use this score page

  • Start with P value and the main performance metrics above to judge whether this model is useful in this cohort.
  • Use the top-percentile rows to see how strongly the score separates the upper PRS tail.
  • Use the linked PheWAS follow-up after the primary-trait evaluation, not as a substitute for it.

Flag guide: nominally significant passed the preserved release's nominal threshold; reversed effect means the observed direction ran opposite to the expected effect direction in the preserved evaluation.

Files and next steps

Start with the interactive PheWAS page to inspect notable associations for this score. Use the PRS PheWAS file for the full phenome scan, the exclusion PheWAS file for secondary associations after removing primary or related trait cases, and the weight link when you need the score construction itself. See the Method page for metric definitions and cohort context.

Related links and downloads