Colorectal cancer (MGI) · Cancer PRSweb

Model details

PRS IDprsweb-phecode153-gwas-catalog-r2019-05-03-x153-p-5e-05-mgi-20200608

Legacy IDPRSWEB_PHECODE153_GWAS-Catalog-r2019-05-03-X153_P_5e-05_MGI_20200608

Legacy modelP_5e-05

# SNPs27

Discovery GWAS trait/source GWAS Catalog (2019-05-03)

Genome buildGRCh37/hg19

Tuning parameterP<=5e-05

Reference Publication PubMed search: 17618284, 17934461, 18372901, 19011631, 23266556, 24737748, 25990418, 26151821, 28960316

Last updated2020-06-08

Evaluation details

Evaluation cohortMichigan Genomics Initiative

Evaluation trait Colorectal cancer
153

Trait typeBinary

SexBoth

Cases607

Controls6026

PRS performance

P value0.095

Pseudo-R²0.005

Brier score0.083

AAUC0.516

AAUC CI0.492-0.538

Percentile effect metricOR

Top percentile	OR	95% CI
1%	1.89	1.00-3.59
2%	1.46	0.87-2.42
5%	1.05	0.72-1.52
10%	0.91	0.68-1.21
25%	1.10	0.91-1.33

How to use this score page

Start with P value and the main performance metrics above to judge whether this model is useful in this cohort.
Use the top-percentile rows to see how strongly the score separates the upper PRS tail.
Use the main Scores table to compare alternative models for the same trait when no preserved PheWAS follow-up is attached.

Flag guide: nominally significant passed the preserved release's nominal threshold; reversed effect means the observed direction ran opposite to the expected effect direction in the preserved evaluation.

Files and next steps

This release keeps the score metadata and performance summary for this model, but it does not preserve a rendered PheWAS result set or downloadable scan tables for it. Use the main Scores table to compare alternative models for the same trait, and see the Method page for cohort and metric definitions.