Cancer of bronchus; lung (MGI)

Model details

PRS IDprsweb-phecode165-1-lung-cancer-mesot-p-5e-07-mgi-20200608

Legacy IDPRSWEB_PHECODE165.1_LUNG-CANCER-MESOT_P_5e-07_MGI_20200608

Legacy modelP_5e-07

Evaluation cohortMichigan Genomics Initiative

Trait typeBinary

SexBoth

Cases428

Controls4270

Genome buildGRCh37/hg19

Tuning parameterP<=5e-07

Reference UKB_GWAS
PubMed 30104761

Last updated2020-06-08

Performance summary

# SNPs7

P value0.67

Pseudo-R²0.0002

Brier score0.0828

AAUC0.493

AAUC CI0.466-0.52

Percentile effect metricOR

Top percentile	OR	95% CI
1%	0.561	0.155-2.04
2%	0.624	0.261-1.49
5%	0.705	0.417-1.19
10%	1.09	0.789-1.5
25%	1.14	0.914-1.43

How to use this score page

Start with P value and the main performance metrics above to judge whether this model is useful in this cohort.
Use the top-percentile rows to see how strongly the score separates the upper PRS tail.
Use the main Scores table to compare alternative models for the same trait when no preserved PheWAS follow-up is attached.

Flag guide: nominally significant passed the preserved release's nominal threshold; reversed effect means the observed direction ran opposite to the expected effect direction in the preserved evaluation.

Files and next steps

This release keeps the score metadata and performance summary for this model, but it does not preserve a rendered PheWAS result set or downloadable scan tables for it. Use the main Scores table to compare alternative models for the same trait, and see the Method page for cohort and metric definitions.

Cancer PRSweb