Departments of Anesthesiology and Biostatistics | University of Michigan

Model details

PRS IDprsweb-phecode172-22-cscc-chahal-p-5e-05-ukb-20200608
Legacy IDPRSWEB_PHECODE172.22_cSCC-Chahal_P_5e-05_UKB_20200608
Legacy modelP_5e-05
Evaluation cohortUK Biobank
Trait typeBinary
SexBoth
Cases5450
Controls54568
Genome buildGRCh37/hg19
Tuning parameterP<=5e-05
Reference PubMed 27424798
Last updated2020-06-08

Performance summary

# SNPs10
P value4.3e-94
Pseudo-R²0.014
Brier score0.082
AAUC0.57
AAUC CI0.562-0.578
Percentile effect metricOR

Top percentile OR 95% CI
1%1.751.4-2.18
2%1.791.53-2.09
5%1.831.65-2.02
10%1.771.64-1.91
25%1.661.57-1.76

How to use this score page

  • Start with P value and the main performance metrics above to judge whether this model is useful in this cohort.
  • Use the top-percentile rows to see how strongly the score separates the upper PRS tail.
  • Use the main Scores table to compare alternative models for the same trait when no preserved PheWAS follow-up is attached.

Flag guide: nominally significant passed the preserved release's nominal threshold; reversed effect means the observed direction ran opposite to the expected effect direction in the preserved evaluation.

Files and next steps

This release keeps the score metadata and performance summary for this model, but it does not preserve a rendered PheWAS result set or downloadable scan tables for it. Use the main Scores table to compare alternative models for the same trait, and see the Method page for cohort and metric definitions.

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