Departments of Anesthesiology and Biostatistics | University of Michigan

Model details

PRS IDprsweb-phecode172-22-gwas-catalog-r2019-05-03-x172-22-pt-ukb-20200608
Legacy IDPRSWEB_PHECODE172.22_GWAS-Catalog-r2019-05-03-X172.22_PT_UKB_20200608
Legacy modelP&T
Catalog record ID PGS000464
Evaluation cohortUK Biobank
Trait typeBinary
SexBoth
Cases5450
Controls54568
Genome buildGRCh37/hg19
Tuning parameterP<=1e-07
Last updated2020-06-08

Performance summary

# SNPs14
P value4.1e-93
Pseudo-R²0.0148
Brier score0.082
AAUC0.575
AAUC CI0.567-0.582
Percentile effect metricOR

Top percentile OR 95% CI
1%2.191.79-2.67
2%1.891.62-2.2
5%1.821.65-2.02
10%1.711.58-1.85
25%1.621.53-1.72

How to use this score page

  • Start with P value and the main performance metrics above to judge whether this model is useful in this cohort.
  • Use the top-percentile rows to see how strongly the score separates the upper PRS tail.
  • Use the linked PheWAS follow-up after the primary-trait evaluation, not as a substitute for it.

Flag guide: nominally significant passed the preserved release's nominal threshold; reversed effect means the observed direction ran opposite to the expected effect direction in the preserved evaluation.

Files and next steps

Start with the interactive PheWAS page to inspect notable associations for this score. Use the PRS PheWAS file for the full phenome scan, the exclusion PheWAS file for secondary associations after removing primary or related trait cases, and the weight link when you need the score construction itself. See the Method page for metric definitions and cohort context.

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