Breast cancer [female] (UKB)

Scores Trait 174.1 UK Biobank

Breast cancer [female]

Exact trait key: 174.1

Citation and acknowledgement note

You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017).

Binary UKB Fixed threshold (5e-05) Michailidou K et al. 2018 nominally significant

Model details

PRS IDprsweb-phecode174-1-icogs-er-negative-brca-p-5e-05-ukb-20200608

Legacy IDPRSWEB_PHECODE174.1_iCOGS-ER-negative-BRCA_P_5e-05_UKB_20200608

Legacy modelP_5e-05

Evaluation cohortUK Biobank

Trait typeBinary

SexFemale

Cases6242

Controls62289

Genome buildGRCh37/hg19

Tuning parameterP<=5e-05

Reference PubMed 29059683

Last updated2020-06-08

Performance summary

# SNPs158

P value3.1e-12

Pseudo-R²0.002

Brier score0.0827

AAUC0.526

AAUC CI0.518-0.533

Percentile effect metricOR

Top percentile	OR	95% CI
1%	1.21	0.952-1.54
2%	1.28	1.09-1.52
5%	1.21	1.09-1.35
10%	1.18	1.09-1.28
25%	1.12	1.05-1.18

How to use this score page

Start with P value and the main performance metrics above to judge whether this model is useful in this cohort.
Use the top-percentile rows to see how strongly the score separates the upper PRS tail.
Use the main Scores table to compare alternative models for the same trait when no preserved PheWAS follow-up is attached.

Flag guide: nominally significant passed the preserved release's nominal threshold; reversed effect means the observed direction ran opposite to the expected effect direction in the preserved evaluation.

Files and next steps

This release keeps the score metadata and performance summary for this model, but it does not preserve a rendered PheWAS result set or downloadable scan tables for it. Use the main Scores table to compare alternative models for the same trait, and see the Method page for cohort and metric definitions.

Cancer PRSweb