Cancer of prostate (MGI) · Cancer PRSweb

Model details

PRS IDprsweb-phecode185-gwas-catalog-r2019-05-03-x185-p-5e-08-mgi-20200608

Legacy IDPRSWEB_PHECODE185_GWAS-Catalog-r2019-05-03-X185_P_5e-08_MGI_20200608

Legacy modelP_5e-08

# SNPs117

Catalog record ID PGS000577

Discovery GWAS trait/source GWAS Catalog (2019-05-03)

Genome buildGRCh37/hg19

Tuning parameterP<=5e-08

Reference Publication PubMed search: 17401363, 17401366, 17603485, 18264096, 18264097, 18264098, 19117981, 19767754, 21743057, 21743467, 23104005, 23535732, 24740154, 25939597, 27262462, 29892016, 30410027

Last updated2020-06-08

Evaluation details

Evaluation cohortMichigan Genomics Initiative

Evaluation trait Prostate cancer;Prostate cancer (early onset)
185

Trait typeBinary

SexMale

Cases1190

Controls4417

PRS performance

P value1.9e-53

Pseudo-R²0.063

Brier score0.147

AAUC0.646

AAUC CI0.627-0.665

Percentile effect metricOR

Top percentile	OR	95% CI
1%	3.57	2.29-5.57
2%	2.91	2.06-4.10
5%	2.97	2.36-3.73
10%	2.75	2.30-3.29
25%	2.66	2.31-3.06

How to use this score page

Start with P value and the main performance metrics above to judge whether this model is useful in this cohort.
Use the top-percentile rows to see how strongly the score separates the upper PRS tail.
Use the linked PheWAS follow-up after the primary-trait evaluation, not as a substitute for it.

Flag guide: nominally significant passed the preserved release's nominal threshold; reversed effect means the observed direction ran opposite to the expected effect direction in the preserved evaluation.

Files and next steps

Start with the interactive PheWAS page to inspect notable associations for this score. Use the PRS PheWAS file for the full phenome scan, the exclusion PheWAS file for secondary associations after removing primary or related trait cases, and the weight link when you need the score construction itself. See the Method page for metric definitions and cohort context.