Model details

PRS IDprsweb-phecode185-pca-practical-lassosum-mgi-20200608
Legacy IDPRSWEB_PHECODE185_Pca-PRACTICAL_LASSOSUM_MGI_20200608
Legacy modelLassosum
# SNPs26418
Catalog record ID PGS000587
Discovery GWAS trait/source Schumacher FR et al. 2019
Genome buildGRCh37/hg19
Tuning parameters=0.5;Lambda=0.006952
Reference Publication PubMed 29892016
Last updated2020-06-08

Evaluation details

Evaluation cohortMichigan Genomics Initiative
Evaluation trait Prostate cancer
185
Trait typeBinary
SexMale
Cases1190
Controls4417

PRS performance

P value3.3e-66
Pseudo-R²0.092
Brier score0.145
AAUC0.665
AAUC CI0.647-0.684
Percentile effect metricOR

Top percentile OR 95% CI
1%4.923.21-7.55
2%3.982.88-5.50
5%3.262.60-4.08
10%2.982.50-3.56
25%2.782.41-3.20

How to use this score page

  • Start with P value and the main performance metrics above to judge whether this model is useful in this cohort.
  • Use the top-percentile rows to see how strongly the score separates the upper PRS tail.
  • Use the linked PheWAS follow-up after the primary-trait evaluation, not as a substitute for it.

Flag guide: nominally significant passed the preserved release's nominal threshold; reversed effect means the observed direction ran opposite to the expected effect direction in the preserved evaluation.

Files and next steps

Start with the interactive PheWAS page to inspect notable associations for this score. Use the PRS PheWAS file for the full phenome scan, the exclusion PheWAS file for secondary associations after removing primary or related trait cases, and the weight link when you need the score construction itself. See the Method page for metric definitions and cohort context.