Cancer of prostate (MGI) · Cancer PRSweb

Model details

PRS IDprsweb-phecode185-ukbb-saige-hrc-x185-prs-cs-mgi-20200608

Legacy IDPRSWEB_PHECODE185_UKBB-SAIGE-HRC-X185_PRS-CS_MGI_20200608

Legacy modelPRS-CS

# SNPs1119236

Catalog record ID PGS000590

Discovery GWAS trait/source UKB GWAS (PheCode)

Genome buildGRCh37/hg19

Tuning parameterauto

Reference Publication UKB_GWAS
PubMed 30104761

Last updated2020-06-08

Evaluation details

Evaluation cohortMichigan Genomics Initiative

Evaluation trait Cancer of prostate
185

Trait typeBinary

SexMale

Cases1190

Controls4417

PRS performance

P value3.8e-32

Pseudo-R²0.035

Brier score0.150

AAUC0.614

AAUC CI0.595-0.633

Percentile effect metricOR

Top percentile	OR	95% CI
1%	2.32	1.42-3.78
2%	2.46	1.72-3.53
5%	2.56	2.02-3.26
10%	2.11	1.75-2.55
25%	1.85	1.61-2.13

How to use this score page

Start with P value and the main performance metrics above to judge whether this model is useful in this cohort.
Use the top-percentile rows to see how strongly the score separates the upper PRS tail.
Use the linked PheWAS follow-up after the primary-trait evaluation, not as a substitute for it.

Flag guide: nominally significant passed the preserved release's nominal threshold; reversed effect means the observed direction ran opposite to the expected effect direction in the preserved evaluation.

Files and next steps

Start with the interactive PheWAS page to inspect notable associations for this score. Use the PRS PheWAS file for the full phenome scan, the exclusion PheWAS file for secondary associations after removing primary or related trait cases, and the weight link when you need the score construction itself. See the Method page for metric definitions and cohort context.