Departments of Anesthesiology and Biostatistics | University of Michigan

Model details

PRS IDprsweb-phecode200-ukbb-saige-hrc-x200-pt-mgi-20200608
Legacy IDPRSWEB_PHECODE200_UKBB-SAIGE-HRC-X200_PT_MGI_20200608
Legacy modelP&T
Evaluation cohortMichigan Genomics Initiative
Trait typeBinary
SexBoth
Cases440
Controls4400
Genome buildGRCh37/hg19
Tuning parameterP<=7.94e-06
Reference UKB_GWAS
PubMed 30104761
Last updated2020-06-08

Performance summary

# SNPs25
P value0.67
Pseudo-R²0.0019
Brier score0.0826
AAUC0.493
AAUC CI0.466-0.519
Percentile effect metricOR

Top percentile OR 95% CI
1%1.240.504-3.05
2%1.30.695-2.42
5%1.110.724-1.71
10%0.9330.668-1.3
25%0.9980.796-1.25

How to use this score page

  • Start with P value and the main performance metrics above to judge whether this model is useful in this cohort.
  • Use the top-percentile rows to see how strongly the score separates the upper PRS tail.
  • Use the main Scores table to compare alternative models for the same trait when no preserved PheWAS follow-up is attached.

Flag guide: nominally significant passed the preserved release's nominal threshold; reversed effect means the observed direction ran opposite to the expected effect direction in the preserved evaluation.

Files and next steps

This release keeps the score metadata and performance summary for this model, but it does not preserve a rendered PheWAS result set or downloadable scan tables for it. Use the main Scores table to compare alternative models for the same trait, and see the Method page for cohort and metric definitions.

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