Lymphoid leukemia (MGI) · Cancer PRSweb

Scores Trait 204.1 Michigan Genomics Initiative

Lymphoid leukemia

Exact trait key: 204.1

GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018.

Binary MGI P&T UKB GWAS (FINNGEN) nominally significant

This PRS has a linked catalog record and a separate weight-file download.

Model details

PRS IDprsweb-phecode204-1-c-lymphoid-leukaemia-pt-mgi-20200608

Legacy IDPRSWEB_PHECODE204.1_C-LYMPHOID-LEUKAEMIA_PT_MGI_20200608

Legacy modelP&T

Catalog record ID PGS000645

Evaluation cohortMichigan Genomics Initiative

Trait typeBinary

SexBoth

Cases87

Controls870

Genome buildGRCh37/hg19

Tuning parameterP<=1e-06

Reference UKB_GWAS
PubMed 30104761

Last updated2020-06-08

Performance summary

# SNPs6

P value0.0026

Pseudo-R²0.0155

Brier score0.0819

AAUC0.578

AAUC CI0.517-0.642

Percentile effect metricOR

Top percentile	OR	95% CI
1%	3.69	1.01-13.4
2%	2.53	0.864-7.44
5%	1.99	0.919-4.31
10%	1.78	0.968-3.27
25%	1.66	1.05-2.63

How to use this score page

Start with P value and the main performance metrics above to judge whether this model is useful in this cohort.
Use the top-percentile rows to see how strongly the score separates the upper PRS tail.
Use the linked PheWAS follow-up after the primary-trait evaluation, not as a substitute for it.

Flag guide: nominally significant passed the preserved release's nominal threshold; reversed effect means the observed direction ran opposite to the expected effect direction in the preserved evaluation.

Files and next steps

Start with the interactive PheWAS page to inspect notable associations for this score. Use the PRS PheWAS file for the full phenome scan, the exclusion PheWAS file for secondary associations after removing primary or related trait cases, and the weight link when you need the score construction itself. See the Method page for metric definitions and cohort context.