PRS scores
Use the filters below to narrow the main PRS catalog. Binary traits report percentile odds ratios, while quantitative traits report percentile beta values. Click any sortable column header to reorder rows; this table defaults to increasing p-value.
Filter defaults and flag guide
By default the row filters open on retained rows so the table starts with the models most likely to be useful for comparison. “Hide non-nominal rows” keeps only rows that were nominally significant in the preserved release, and “Hide flagged rows” removes reversed-effect or underpowered rows. Turn either filter off when you need the full preserved table.
Flag guide: nominal = passed the preserved release's nominal threshold; weak = did not; reversed effect = observed direction opposite the expected effect direction; retained = nominal and warning-free. When the trait list feels too long, use the free-text Search box first.
| Trait code | Trait | Cohort | Method | GWAS source | # SNPs | P value | R² / pseudo-R² | Brier | MSE | AAUC | Top 1% effect | Flags | Links |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
Height
GIANT-Yang2012-height |
Height |
UKB | PRS-CS | Large GWAS | 996840 | 4.9e-13188 | 0.1056 | 30.7171 | 0.892 Beta 95% CI: 0.871-0.913 |
Quantitative
nominal
|
|||
|
Height
ieu-a-89 |
Height |
UKB | PRS-CS | Large GWAS | 915553 | 4.9e-13188 | 0.1056 | 30.7171 | 0.892 Beta 95% CI: 0.871-0.913 |
Quantitative
nominal
|
|||
|
Height
ieu-a-89 |
Height |
UKB | C+T (DS) | Large GWAS | 6903 | 1.2e-11925 | 0.0978 | 31.4077 | 0.862 Beta 95% CI: 0.841-0.883 |
Quantitative
nominal
|
|||
|
Height
ieu-a-89 |
Height |
UKB | C+T (GT) | Large GWAS | 7080 | 4.3e-11878 | 0.0967 | 31.4343 | 0.867 Beta 95% CI: 0.846-0.888 |
Quantitative
nominal
|
|||
|
Height
GIANT-Yang2012-height |
Height |
UKB | lassosum | Large GWAS | 67333 | 4.2e-10589 | 0.0905 | 32.1735 | 0.823 Beta 95% CI: 0.802-0.844 |
Quantitative
nominal
|
|||
|
Height
ieu-a-89 |
Height |
UKB | lassosum | Large GWAS | 282132 | 4.2e-10589 | 0.0905 | 32.1735 | 0.823 Beta 95% CI: 0.802-0.844 |
Quantitative
nominal
|
|||
|
Smoking
SmokingInitiation |
Smoking initiation SmokingInitiation |
UKB | C+T (GT) | Large GWAS | 39469 | 2.3e-6988 | 0.2252 | 0.189 | 0.1891 | 0.767 0.765-0.769 |
62.4 OR 95% CI: 47.4-82.1 |
Binary
nominal
|
|
|
Smoking
SmokingInitiation |
Smoking initiation SmokingInitiation |
UKB | lassosum | Large GWAS | 642068 | 8.1e-4376 | 0.1353 | 0.209 | 0.2086 | 0.698 0.696-0.7 |
13 OR 95% CI: 11.4-14.9 |
Binary
nominal
|
|
|
eGFR
20171017-MW-eGFR-EA |
Estimated glomerular filtration rate eGFR |
UKB | lassosum | Large GWAS | 456946 | 9.5e-4023 | 0.0699 | 125.9764 | 0.605 Beta 95% CI: 0.5772-0.6328 |
Quantitative
nominal
|
|||
|
eGFR
20171017-MW-eGFR-EA |
Estimated glomerular filtration rate eGFR |
UKB | PRS-CS | Large GWAS | 1118118 | 2.4e-3563 | 0.0624 | 127.237 | 0.604 Beta 95% CI: 0.5762-0.6318 |
Quantitative
nominal
|
|||
|
eGFR
20171017-MW-eGFR-EA |
Estimated glomerular filtration rate eGFR |
UKB | DBSLMM | Large GWAS | 4728961 | 4.3e-3279 | 0.0569 | 128.0297 | 0.579 Beta 95% CI: 0.5512-0.6068 |
Quantitative
nominal
|
|||
|
Smoking
SmokingInitiation |
Smoking initiation SmokingInitiation |
UKB | C+T (DS) | Large GWAS | 17138 | 1.9e-3208 | 0.0997 | 0.216 | 0.2161 | 0.665 0.663-0.667 |
7.12 OR 95% CI: 6.4-7.91 |
Binary
nominal
|
|
|
eGFR
20171017-MW-eGFR-EA |
Estimated glomerular filtration rate eGFR |
UKB | C+T (DS) | Large GWAS | 2092 | 4.5e-2945 | 0.0537 | 128.9739 | 0.521 Beta 95% CI: 0.4932-0.5488 |
Quantitative
nominal
|
|||
|
eGFR
20171017-MW-eGFR-EA |
Estimated glomerular filtration rate eGFR |
UKB | C+T (GT) | Large GWAS | 2127 | 3.4e-2920 | 0.0532 | 129.0447 | 0.524 Beta 95% CI: 0.4962-0.5518 |
Quantitative
nominal
|
|||
|
T2D
30054458-GCST006867 |
Type 2 diabetes T2D |
UKB | lassosum | Large GWAS | 555528 | 2.1e-2790 | 0.2426 | 0.0373 | 0.0373 | 0.825 0.82-0.829 |
34.9 OR 95% CI: 32.7-37.4 |
Binary
nominal
|
|
|
T2D
30054458-GCST006867 |
Type 2 diabetes T2D |
UKB | C+T (DS) | Large GWAS | 31462 | 5.3e-2671 | 0.2282 | 0.0379 | 0.0379 | 0.816 0.811-0.82 |
32.1 OR 95% CI: 30-34.3 |
Binary
nominal
|
|
|
T2D
30054458-GCST006867 |
Type 2 diabetes T2D |
UKB | C+T (GT) | Large GWAS | 31462 | 5.3e-2671 | 0.2282 | 0.0379 | 0.0379 | 0.816 0.811-0.82 |
32.1 OR 95% CI: 30-34.3 |
Binary
nominal
|
|
|
Smoking
SmokingInitiation |
Smoking initiation SmokingInitiation |
UKB | PRS-CS | Large GWAS | 1110662 | 3.4e-2174 | 0.0654 | 0.222 | 0.2224 | 0.633 0.63-0.635 |
4.55 OR 95% CI: 4.15-4.98 |
Binary
nominal
|
|
|
T2D
30054458-GCST006867 |
Type 2 diabetes T2D |
UKB | PRS-CS | Large GWAS | 945921 | 9.7e-2116 | 0.1706 | 0.0406 | 0.0406 | 0.786 0.782-0.791 |
16.8 OR 95% CI: 15.7-17.9 |
Binary
nominal
|
|
|
T2D
30054458-GCST006867 |
Type 2 diabetes T2D |
UKB | DBSLMM | Large GWAS | 5052993 | 3.6e-2005 | 0.1566 | 0.0409 | 0.0409 | 0.778 0.774-0.783 |
15.7 OR 95% CI: 14.7-16.8 |
Binary
nominal
|
|
|
Height
50-raw |
Standing height Field 50, raw |
MGI | PRS-CS | UK Biobank GWAS | 1113832 | 2.2e-1988 | 0.1376 | 33.284 | 0.933 Beta 95% CI: 0.872-0.994 |
Quantitative
nominal
|
|||
|
Height
50-irnt |
Standing height (IRNT) Standing height; Field 50, IRNT |
MGI | PRS-CS | UK Biobank GWAS | 1113832 | 1.1e-1979 | 0.1374 | 33.3251 | 0.941 Beta 95% CI: 0.88-1.002 |
Quantitative
nominal
|
|||
|
eGFRcys
eGFRcys-overall-IV-2GC |
Estimated glomerular filtration rate based on cystatin C eGFRcys |
UKB | lassosum | Large GWAS | 62626 | 6.7e-1908 | 0.0356 | 0.0241 | -0.58 Beta 95% CI: -0.6094--0.5506 |
Quantitative
nominal
reversed effect
|
|||
|
Height
50-raw |
Standing height Field 50, raw |
MGI | lassosum | UK Biobank GWAS | 1296068 | 3.2e-1898 | 0.1297 | 33.7149 | 0.929 Beta 95% CI: 0.868-0.99 |
Quantitative
nominal
|
|||
|
Height
50-irnt |
Standing height (IRNT) Standing height; Field 50, IRNT |
MGI | lassosum | UK Biobank GWAS | 1291379 | 9.4e-1888 | 0.1296 | 33.7657 | 0.929 Beta 95% CI: 0.868-0.99 |
Quantitative
nominal
|
|||
|
eGFRcys
CKDGen-1000Genomes-DiscoveryMeta-eGFRcys |
Estimated glomerular filtration rate based on cystatin C eGFRcys |
UKB | lassosum | Large GWAS | 174315 | 1.3e-1818 | 0.0358 | 0.025 | 0.363 Beta 95% CI: 0.3336-0.3924 |
Quantitative
nominal
|
|||
|
Height
50-raw |
Standing height Field 50, raw |
MGI | C+T (DS) | UK Biobank GWAS | 31805 | 8.6e-1725 | 0.1262 | 34.576 | 0.885 Beta 95% CI: 0.824-0.946 |
Quantitative
nominal
|
|||
|
Height
50-irnt |
Standing height (IRNT) Standing height; Field 50, IRNT |
MGI | C+T (DS) | UK Biobank GWAS | 34284 | 1.8e-1720 | 0.1258 | 34.598 | 0.893 Beta 95% CI: 0.832-0.954 |
Quantitative
nominal
|
|||
|
eGFRcys
eGFRcys-overall-IV-2GC |
Estimated glomerular filtration rate based on cystatin C eGFRcys |
UKB | C+T (DS) | Large GWAS | 2 | 9e-1713 | 0.0315 | 0.0242 | -0.498 Beta 95% CI: -0.5126--0.4834 |
Quantitative
nominal
reversed effect
|
|||
|
eGFRcys
eGFRcys-overall-IV-2GC |
Estimated glomerular filtration rate based on cystatin C eGFRcys |
UKB | C+T (GT) | Large GWAS | 2 | 9e-1713 | 0.0315 | 0.0242 | -0.498 Beta 95% CI: -0.5126--0.4834 |
Quantitative
nominal
reversed effect
|
|||
|
Height
50-raw |
Standing height Field 50, raw |
MGI | C+T (GT) | UK Biobank GWAS | 44500 | 2.5e-1708 | 0.1225 | 34.66 | 0.883 Beta 95% CI: 0.822-0.944 |
Quantitative
nominal
|
|||
|
eGFRcys
eGFRcys-overall-EA |
Estimated glomerular filtration rate based on cystatin C eGFRcys |
UKB | lassosum | Large GWAS | 1954 | 6.3e-1704 | 0.031 | 0.0242 | -0.531 Beta 95% CI: -0.5604--0.5016 |
Quantitative
nominal
reversed effect
|
|||
|
Height
50-irnt |
Standing height (IRNT) Standing height; Field 50, IRNT |
MGI | C+T (GT) | UK Biobank GWAS | 49307 | 3.5e-1692 | 0.1229 | 34.7429 | 0.878 Beta 95% CI: 0.817-0.939 |
Quantitative
nominal
|
|||
|
eGFRcys
CKDGen-1000Genomes-DiscoveryMeta-eGFRcys |
Estimated glomerular filtration rate based on cystatin C eGFRcys |
UKB | C+T (DS) | Large GWAS | 15 | 3.3e-1661 | 0.0326 | 0.0251 | 0.387 Beta 95% CI: 0.3578-0.4162 |
Quantitative
nominal
|
|||
|
eGFRcys
CKDGen-1000Genomes-DiscoveryMeta-eGFRcys |
Estimated glomerular filtration rate based on cystatin C eGFRcys |
UKB | C+T (GT) | Large GWAS | 15 | 1e-1659 | 0.0325 | 0.0251 | 0.388 Beta 95% CI: 0.3588-0.4172 |
Quantitative
nominal
|
|||
|
eGFRcys
eGFRcys-overall-EA |
Estimated glomerular filtration rate based on cystatin C eGFRcys |
UKB | C+T (GT) | Large GWAS | 7 | 1.1e-1534 | 0.0279 | 0.0243 | -0.534 Beta 95% CI: -0.5634--0.5046 |
Quantitative
nominal
reversed effect
|
|||
|
eGFRcys
eGFRcys-overall-EA |
Estimated glomerular filtration rate based on cystatin C eGFRcys |
UKB | C+T (DS) | Large GWAS | 6 | 2.9e-1506 | 0.0275 | 0.0243 | -0.539 Beta 95% CI: -0.5678--0.5102 |
Quantitative
nominal
reversed effect
|
|||
|
eGFRcr
CKDGen-1000Genomes-DiscoveryMeta-eGFRcrea |
Estimated glomerular filtration rate based on creatinine eGFRcrea |
UKB | PRS-CS | Large GWAS | 1109812 | 1.7e-1454 | 0.0232 | 224.6335 | 0.428 Beta 95% CI: 0.4004-0.4556 |
Quantitative
nominal
|
|||
|
eGFRcys
eGFRcys-overall-EA |
Estimated glomerular filtration rate based on cystatin C eGFRcys |
UKB | DBSLMM | Large GWAS | 6375 | 3.6e-1416 | 0.0258 | 0.0244 | -0.504 Beta 95% CI: -0.5334--0.4746 |
Quantitative
nominal
reversed effect
|
|||
|
eGFRcr
eGFRcrea-overall-IV-2GC |
Estimated glomerular filtration rate based on creatinine eGFRcrea |
UKB | lassosum | Large GWAS | 87693 | 1.6e-1414 | 0.022 | 222.3617 | -0.393 Beta 95% CI: -0.4206--0.3654 |
Quantitative
nominal
reversed effect
|
|||
|
eGFRcr
CKDGen-1000Genomes-DiscoveryMeta-eGFRcrea |
Estimated glomerular filtration rate based on creatinine eGFRcrea |
UKB | lassosum | Large GWAS | 214280 | 1.3e-1332 | 0.0217 | 225.2603 | 0.435 Beta 95% CI: 0.4074-0.4626 |
Quantitative
nominal
|
|||
|
eGFRcr
eGFRcrea-overall-IV-2GC |
Estimated glomerular filtration rate based on creatinine eGFRcrea |
UKB | PRS-CS | Large GWAS | 932878 | 1.5e-1303 | 0.0208 | 222.927 | -0.358 Beta 95% CI: -0.3856--0.3304 |
Quantitative
nominal
reversed effect
|
|||
|
eGFRcys
eGFRcys-overall-IV-2GC |
Estimated glomerular filtration rate based on cystatin C eGFRcys |
UKB | PRS-CS | Large GWAS | 933341 | 6.4e-1290 | 0.0251 | 0.0245 | -0.484 Beta 95% CI: -0.5134--0.4546 |
Quantitative
nominal
reversed effect
|
|||
|
eGFRcys
CKDGen-1000Genomes-DiscoveryMeta-eGFRcys |
Estimated glomerular filtration rate based on cystatin C eGFRcys |
UKB | PRS-CS | Large GWAS | 1114999 | 3.8e-1268 | 0.0243 | 0.0253 | 0.375 Beta 95% CI: 0.3456-0.4044 |
Quantitative
nominal
|
|||
|
Vit D
29343764-GCST005367 |
Vitamin D |
UKB | lassosum | Large GWAS | 109290 | 3.3e-1114 | 0.0251 | 421.9665 | 0.364 Beta 95% CI: 0.3319-0.3961 |
Quantitative
nominal
|
|||
|
Height
ieu-a-89 |
Height |
MGI | C+T (DS) | Large GWAS | 2469 | 2.2e-1081 | 0.0778 | 38.195 | 0.761 Beta 95% CI: 0.7-0.822 |
Quantitative
nominal
|
|||
|
Vit D
29343764-GCST005367 |
Vitamin D |
UKB | PRS-CS | Large GWAS | 1058756 | 4.2e-1051 | 0.0256 | 422.6068 | 0.39 Beta 95% CI: 0.3579-0.4221 |
Quantitative
nominal
|
|||
|
Height
ieu-a-89 |
Height |
MGI | C+T (GT) | Large GWAS | 2500 | 2.9e-1049 | 0.0771 | 38.3956 | 0.768 Beta 95% CI: 0.707-0.829 |
Quantitative
nominal
|
|||
|
eGFRcr
eGFRcrea-overall-IV-2GC |
Estimated glomerular filtration rate based on creatinine eGFRcrea |
UKB | C+T (GT) | Large GWAS | 458 | 3.7e-1049 | 0.0157 | 224.2337 | -0.348 Beta 95% CI: -0.3756--0.3204 |
Quantitative
nominal
reversed effect
|
|||
|
eGFRcr
eGFRcrea-overall-IV-2GC |
Estimated glomerular filtration rate based on creatinine eGFRcrea |
UKB | C+T (DS) | Large GWAS | 458 | 3e-1042 | 0.0157 | 224.2694 | -0.341 Beta 95% CI: -0.3686--0.3134 |
Quantitative
nominal
reversed effect
|
|||
|
Vit D
29343764-GCST005367 |
Vitamin D |
UKB | C+T (DS) | Large GWAS | 23 | 7.7e-1017 | 0.0234 | 422.9552 | 0.35 Beta 95% CI: 0.3179-0.3821 |
Quantitative
nominal
|
|||
|
Vit D
29343764-GCST005367 |
Vitamin D |
UKB | C+T (GT) | Large GWAS | 22 | 1.2e-1008 | 0.0233 | 423.0385 | 0.362 Beta 95% CI: 0.3299-0.3941 |
Quantitative
nominal
|
|||
|
eGFRcr
eGFRcrea-overall-EA |
Estimated glomerular filtration rate based on creatinine eGFRcrea |
UKB | lassosum | Large GWAS | 2989 | 1.3e-892 | 0.0132 | 225.0454 | -0.319 Beta 95% CI: -0.3466--0.2914 |
Quantitative
nominal
reversed effect
|
|||
|
Height
ieu-a-89 |
Height |
MGI | PRS-CS | Large GWAS | 915020 | 1.7e-884 | 0.0567 | 39.4586 | 0.691 Beta 95% CI: 0.6298-0.7522 |
Quantitative
nominal
|
|||
|
eGFRcr
CKDGen-1000Genomes-DiscoveryMeta-eGFRcrea |
Estimated glomerular filtration rate based on creatinine eGFRcrea |
UKB | C+T (DS) | Large GWAS | 176 | 5.1e-847 | 0.0132 | 227.7922 | 0.318 Beta 95% CI: 0.2904-0.3456 |
Quantitative
nominal
|
|||
|
eGFRcr
CKDGen-1000Genomes-DiscoveryMeta-eGFRcrea |
Estimated glomerular filtration rate based on creatinine eGFRcrea |
UKB | C+T (GT) | Large GWAS | 176 | 4.3e-845 | 0.0132 | 227.8023 | 0.33 Beta 95% CI: 0.3024-0.3576 |
Quantitative
nominal
|
|||
|
eGFRcr
eGFRcrea-overall-IV-2GC |
Estimated glomerular filtration rate based on creatinine eGFRcrea |
UKB | DBSLMM | Large GWAS | 963494 | 1.3e-840 | 0.014 | 225.3163 | -0.3 Beta 95% CI: -0.3276--0.2724 |
Quantitative
nominal
reversed effect
|
|||
|
eGFRcr
eGFRcrea-overall-EA |
Estimated glomerular filtration rate based on creatinine eGFRcrea |
UKB | C+T (GT) | Large GWAS | 600 | 1.2e-786 | 0.0119 | 225.5982 | -0.298 Beta 95% CI: -0.3256--0.2704 |
Quantitative
nominal
reversed effect
|
|||
|
eGFRcr
eGFRcrea-overall-EA |
Estimated glomerular filtration rate based on creatinine eGFRcrea |
UKB | C+T (DS) | Large GWAS | 314 | 5.4e-773 | 0.0118 | 225.6696 | -0.267 Beta 95% CI: -0.2946--0.2394 |
Quantitative
nominal
reversed effect
|
|||
|
Height
ieu-a-89 |
Height |
MGI | lassosum | Large GWAS | 280347 | 1e-712 | 0.0528 | 40.6316 | 0.632 Beta 95% CI: 0.5708-0.6932 |
Quantitative
nominal
|
|||
|
Height
50-raw |
Standing height Field 50, raw |
MGI | DBSLMM | UK Biobank GWAS | 10297262 | 6.3e-704 | 0.0627 | 40.6934 | 0.648 Beta 95% CI: 0.5868-0.7092 |
Quantitative
nominal
|
|||
|
Height
50-irnt |
Standing height (IRNT) Standing height; Field 50, IRNT |
MGI | DBSLMM | UK Biobank GWAS | 10297259 | 1.7e-692 | 0.0633 | 40.7742 | 0.657 Beta 95% CI: 0.5958-0.7182 |
Quantitative
nominal
|
|||
|
BMI
21001-raw |
Body mass index Field 21001, raw |
MGI | PRS-CS | UK Biobank GWAS | 1113832 | 5.3e-607 | 0.1075 | 43.9746 | 0.931 Beta 95% CI: 0.8406-1.0214 |
Quantitative
nominal
|
|||
|
BMI
21001-irnt |
Body mass index Field 21001, IRNT |
MGI | PRS-CS | UK Biobank GWAS | 1113832 | 2.8e-605 | 0.1089 | 43.9879 | 0.963 Beta 95% CI: 0.8726-1.0534 |
Quantitative
nominal
|
|||
|
BMI
23104-raw |
Body mass index Field 23104, raw |
MGI | PRS-CS | UK Biobank GWAS | 1113832 | 1.9e-603 | 0.1085 | 44.0021 | 0.958 Beta 95% CI: 0.8676-1.0484 |
Quantitative
nominal
|
|||
|
BMI
23104-irnt |
Body mass index Field 23104, IRNT |
MGI | PRS-CS | UK Biobank GWAS | 1113832 | 4e-595 | 0.1083 | 44.0668 | 0.974 Beta 95% CI: 0.8838-1.0642 |
Quantitative
nominal
|
|||
|
BMI
23104-raw |
Body mass index Field 23104, raw |
MGI | lassosum | UK Biobank GWAS | 1044654 | 6.4e-575 | 0.103 | 0.8857 | 0.943 Beta 95% CI: 0.8528-1.0332 |
Quantitative
nominal
|
|||
|
BMI
21001-irnt |
Body mass index Field 21001, IRNT |
MGI | lassosum | UK Biobank GWAS | 1062550 | 2.7e-568 | 0.1037 | 44.2763 | 0.971 Beta 95% CI: 0.8808-1.0612 |
Quantitative
nominal
|
|||
|
BMI
21001-raw |
Body mass index Field 21001, raw |
MGI | lassosum | UK Biobank GWAS | 1052511 | 1e-566 | 0.1037 | 43.6868 | 0.985 Beta 95% CI: 0.8948-1.0752 |
Quantitative
nominal
|
|||
|
BMI
23104-irnt |
Body mass index Field 23104, IRNT |
MGI | lassosum | UK Biobank GWAS | 1053861 | 2e-563 | 0.1029 | 44.3145 | 0.951 Beta 95% CI: 0.8608-1.0412 |
Quantitative
nominal
|
|||
|
T2D
METAANALYSIS-DIAGRAM |
Type 2 diabetes T2D |
UKB | PRS-CS | Large GWAS | 1119522 | 1e-552 | 0.0403 | 0.0444 | 0.0444 | 0.648 0.642-0.654 |
3.81 OR 95% CI: 3.49-4.16 |
Binary
nominal
|
|
|
T2D
METAANALYSIS-DIAGRAM |
Type 2 diabetes T2D |
UKB | lassosum | Large GWAS | 407553 | 6.2e-497 | 0.0349 | 0.0445 | 0.0445 | 0.639 0.634-0.645 |
3.69 OR 95% CI: 3.38-4.04 |
Binary
nominal
|
|
|
CRP
prot-a-670 |
C-reactive protein |
UKB | C+T (DS) | Large GWAS | 5 | 1.1e-475 | 0.0115 | 18.7187 | 0.308 Beta 95% CI: 0.2766-0.3394 |
Quantitative
nominal
|
|||
|
CRP
prot-a-670 |
C-reactive protein |
UKB | C+T (GT) | Large GWAS | 5 | 1.1e-475 | 0.0115 | 18.7187 | 0.308 Beta 95% CI: 0.2766-0.3394 |
Quantitative
nominal
|
|||
|
CRP
prot-a-670 |
C-reactive protein |
UKB | lassosum | Large GWAS | 370520 | 1.5e-472 | 0.0115 | 18.7201 | 0.31 Beta 95% CI: 0.2786-0.3414 |
Quantitative
nominal
|
|||
|
BMI
23104-irnt |
Body mass index Field 23104, IRNT |
MGI | C+T (DS) | UK Biobank GWAS | 32697 | 3.9e-468 | 0.0823 | 45.0763 | 0.813 Beta 95% CI: 0.7226-0.9034 |
Quantitative
nominal
|
|||
|
BMI
21001-irnt |
Body mass index Field 21001, IRNT |
MGI | C+T (DS) | UK Biobank GWAS | 32980 | 4.1e-467 | 0.0836 | 45.0846 | 0.773 Beta 95% CI: 0.6824-0.8636 |
Quantitative
nominal
|
|||
|
BMI
23104-raw |
Body mass index Field 23104, raw |
MGI | C+T (DS) | UK Biobank GWAS | 28689 | 2e-462 | 0.0858 | 0.9037 | 0.763 Beta 95% CI: 0.6724-0.8536 |
Quantitative
nominal
|
|||
|
BMI
21001-raw |
Body mass index Field 21001, raw |
MGI | C+T (DS) | UK Biobank GWAS | 32526 | 5.7e-453 | 0.0862 | 44.5858 | 0.806 Beta 95% CI: 0.7156-0.8964 |
Quantitative
nominal
|
|||
|
eGFRcr
eGFRcrea-overall-EA |
Estimated glomerular filtration rate based on creatinine eGFRcrea |
UKB | PRS-CS | Large GWAS | 16686 | 3.1e-421 | 0.0061 | 227.5253 | -0.209 Beta 95% CI: -0.2366--0.1814 |
Quantitative
nominal
reversed effect
|
|||
|
BMI
21001-raw |
Body mass index Field 21001, raw |
MGI | C+T (GT) | UK Biobank GWAS | 51370 | 3e-420 | 0.0758 | 44.8513 | 0.773 Beta 95% CI: 0.6824-0.8636 |
Quantitative
nominal
|
|||
|
eGFRcys
eGFRcys-overall-IV-2GC |
Estimated glomerular filtration rate based on cystatin C eGFRcys |
UKB | DBSLMM | Large GWAS | 594334 | 1.4e-411 | 0.0081 | 0.025 | -0.269 Beta 95% CI: -0.2984--0.2396 |
Quantitative
nominal
reversed effect
|
|||
|
BMI
23104-irnt |
Body mass index Field 23104, IRNT |
MGI | C+T (GT) | UK Biobank GWAS | 51563 | 3e-403 | 0.0748 | 45.6102 | 0.759 Beta 95% CI: 0.6686-0.8494 |
Quantitative
nominal
|
|||
|
BMI
23104-raw |
Body mass index Field 23104, raw |
MGI | C+T (GT) | UK Biobank GWAS | 44240 | 5.2e-401 | 0.0777 | 0.9138 | 0.785 Beta 95% CI: 0.6946-0.8754 |
Quantitative
nominal
|
|||
|
BMI
23104-raw |
Body mass index Field 23104, raw |
MGI | DBSLMM | UK Biobank GWAS | 7446652 | 3.2e-395 | 0.0707 | 0.9148 | 0.813 Beta 95% CI: 0.7226-0.9034 |
Quantitative
nominal
|
|||
|
BMI
21001-irnt |
Body mass index Field 21001, IRNT |
MGI | C+T (GT) | UK Biobank GWAS | 51983 | 8.1e-395 | 0.076 | 45.6805 | 0.682 Beta 95% CI: 0.5916-0.7724 |
Quantitative
nominal
|
|||
|
BMI
21001-raw |
Body mass index Field 21001, raw |
MGI | DBSLMM | UK Biobank GWAS | 7444629 | 9.8e-392 | 0.0748 | 45.0852 | 0.803 Beta 95% CI: 0.7126-0.8934 |
Quantitative
nominal
|
|||
|
BMI
21001-irnt |
Body mass index Field 21001, IRNT |
MGI | DBSLMM | UK Biobank GWAS | 7444639 | 2.4e-386 | 0.0751 | 45.7515 | 0.807 Beta 95% CI: 0.7166-0.8974 |
Quantitative
nominal
|
|||
|
BMI
23104-irnt |
Body mass index Field 23104, IRNT |
MGI | DBSLMM | UK Biobank GWAS | 7446664 | 6.6e-379 | 0.0737 | 45.8138 | 0.797 Beta 95% CI: 0.7066-0.8874 |
Quantitative
nominal
|
|||
|
T2D
29358691-GCST005413 |
Type 2 diabetes T2D |
UKB | lassosum | Large GWAS | 311565 | 2.3e-346 | 0.0243 | 0.0448 | 0.0448 | 0.616 0.61-0.622 |
2.92 OR 95% CI: 2.65-3.22 |
Binary
nominal
|
|
|
T2D
29358691-GCST005413 |
Type 2 diabetes T2D |
UKB | PRS-CS | Large GWAS | 1117087 | 8.2e-345 | 0.0262 | 0.0448 | 0.0448 | 0.616 0.611-0.622 |
2.84 OR 95% CI: 2.58-3.13 |
Binary
nominal
|
|
|
Height
GIANT-Yang2012-height |
Height |
UKB | DBSLMM | Large GWAS | 1661426 | 2.21e-308 | 0.0028 | 39.5997 | 0.142 Beta 95% CI: 0.1208-0.1632 |
Quantitative
nominal
|
|||
|
Height
ieu-a-89 |
Height |
UKB | DBSLMM | Large GWAS | 464103 | 2.21e-308 | 0.0028 | 39.5997 | 0.142 Beta 95% CI: 0.1208-0.1632 |
Quantitative
nominal
|
|||
|
TG
30870-irnt |
Triglycerides (IRNT) Triglycerides (quantile); Field 30870, IRNT |
MGI | DBSLMM | UK Biobank GWAS | 8924773 | 6.9e-304 | 0.1046 | 2868.5694 | 0.983 Beta 95% CI: 0.8425-1.1235 |
Quantitative
nominal
|
|||
|
HDL-C
30760-irnt |
HDL cholesterol (IRNT) HDL cholesterol (quantile); Field 30760, IRNT |
MGI | PRS-CS | UK Biobank GWAS | 1113830 | 1.3e-294 | 0.0885 | 142.2496 | 0.841 Beta 95% CI: 0.7099-0.9721 |
Quantitative
nominal
|
|||
|
TG
30870-raw |
Triglycerides (mmol/L) Field 30870, raw |
MGI | DBSLMM | UK Biobank GWAS | 8924752 | 3e-291 | 0.0967 | 2883.8677 | 0.848 Beta 95% CI: 0.7073-0.9887 |
Quantitative
nominal
|
|||
|
HDL-C
30760-raw |
HDL cholesterol (mmol/L) Field 30760, raw |
MGI | PRS-CS | UK Biobank GWAS | 1113830 | 4.2e-291 | 0.0884 | 142.466 | 0.809 Beta 95% CI: 0.6777-0.9403 |
Quantitative
nominal
|
|||
|
Menarche Age
ieu-a-1095 |
Age at menarche |
UKB | C+T (DS) | Large GWAS | 13852 | 4.2e-285 | 0.0114 | 7.6114 | 0.0718 Beta 95% CI: -0.0129-0.1565 |
Quantitative
nominal
|
|||
|
Menarche Age
ieu-a-1095 |
Age at menarche |
UKB | C+T (GT) | Large GWAS | 13852 | 4.2e-285 | 0.0114 | 7.6114 | 0.0718 Beta 95% CI: -0.0129-0.1565 |
Quantitative
nominal
|
|||
|
HDL-C
30760-irnt |
HDL cholesterol (IRNT) HDL cholesterol (quantile); Field 30760, IRNT |
MGI | DBSLMM | UK Biobank GWAS | 7449065 | 2.4e-283 | 0.0968 | 142.9453 | 0.934 Beta 95% CI: 0.8031-1.0649 |
Quantitative
nominal
|
|||
|
Menarche Age
ieu-a-1095 |
Age at menarche |
UKB | PRS-CS | Large GWAS | 895562 | 7.8e-281 | 0.0107 | 7.6127 | 0.0501 Beta 95% CI: -0.0348-0.135 |
Quantitative
nominal
|
|||
|
T2D
METAANALYSIS-DIAGRAM |
Type 2 diabetes T2D |
UKB | C+T (DS) | Large GWAS | 193 | 3.1e-280 | 0.0203 | 0.0449 | 0.0449 | 0.603 0.597-0.609 |
2.51 OR 95% CI: 2.27-2.77 |
Binary
nominal
|
|
|
T2D
METAANALYSIS-DIAGRAM |
Type 2 diabetes T2D |
UKB | C+T (GT) | Large GWAS | 193 | 3.1e-280 | 0.0203 | 0.0449 | 0.0449 | 0.603 0.597-0.609 |
2.51 OR 95% CI: 2.27-2.77 |
Binary
nominal
|
|
|
TG
30870-irnt |
Triglycerides (IRNT) Triglycerides (quantile); Field 30870, IRNT |
MGI | PRS-CS | UK Biobank GWAS | 1113831 | 2e-277 | 0.0912 | 2900.7631 | 0.871 Beta 95% CI: 0.7305-1.0115 |
Quantitative
nominal
|
|||
|
HDL-C
30760-raw |
HDL cholesterol (mmol/L) Field 30760, raw |
MGI | DBSLMM | UK Biobank GWAS | 7449036 | 2e-268 | 0.0923 | 143.8766 | 0.892 Beta 95% CI: 0.7609-1.0231 |
Quantitative
nominal
|
|||
|
HDL-C
30760-irnt |
HDL cholesterol (IRNT) HDL cholesterol (quantile); Field 30760, IRNT |
MGI | C+T (DS) | UK Biobank GWAS | 16393 | 4.6e-263 | 0.0874 | 144.2148 | 0.858 Beta 95% CI: 0.7269-0.9891 |
Quantitative
nominal
|
|||
|
TG
30870-raw |
Triglycerides (mmol/L) Field 30870, raw |
MGI | PRS-CS | UK Biobank GWAS | 1113831 | 1.8e-256 | 0.0876 | 2926.8052 | 0.973 Beta 95% CI: 0.8325-1.1135 |
Quantitative
nominal
|
|||
|
HDL-C
30760-irnt |
HDL cholesterol (IRNT) HDL cholesterol (quantile); Field 30760, IRNT |
MGI | C+T (GT) | UK Biobank GWAS | 25134 | 4.9e-256 | 0.0879 | 144.6601 | 0.824 Beta 95% CI: 0.6929-0.9551 |
Quantitative
nominal
|
|||
|
HDL-C
30760-raw |
HDL cholesterol (mmol/L) Field 30760, raw |
MGI | C+T (DS) | UK Biobank GWAS | 17935 | 1.2e-254 | 0.0846 | 144.7486 | 0.806 Beta 95% CI: 0.6749-0.9371 |
Quantitative
nominal
|
|||
|
TG
30870-irnt |
Triglycerides (IRNT) Triglycerides (quantile); Field 30870, IRNT |
MGI | lassosum | UK Biobank GWAS | 762608 | 4.1e-252 | 0.0848 | 2932.2608 | 0.848 Beta 95% CI: 0.7073-0.9887 |
Quantitative
nominal
|
|||
|
TG
30870-raw |
Triglycerides (mmol/L) Field 30870, raw |
MGI | lassosum | UK Biobank GWAS | 705677 | 4.1e-252 | 0.0833 | 2932.2573 | 0.851 Beta 95% CI: 0.7103-0.9917 |
Quantitative
nominal
|
|||
|
HDL-C
30760-raw |
HDL cholesterol (mmol/L) Field 30760, raw |
MGI | C+T (GT) | UK Biobank GWAS | 28354 | 1.3e-247 | 0.084 | 145.1973 | 0.775 Beta 95% CI: 0.6439-0.9061 |
Quantitative
nominal
|
|||
|
HDL-C
30760-irnt |
HDL cholesterol (IRNT) HDL cholesterol (quantile); Field 30760, IRNT |
MGI | lassosum | UK Biobank GWAS | 815573 | 4.3e-245 | 0.0791 | 145.3591 | 0.916 Beta 95% CI: 0.7849-1.0471 |
Quantitative
nominal
|
|||
|
HDL-C
30760-raw |
HDL cholesterol (mmol/L) Field 30760, raw |
MGI | lassosum | UK Biobank GWAS | 799981 | 1.7e-242 | 0.0778 | 145.5248 | 0.869 Beta 95% CI: 0.7379-1.0001 |
Quantitative
nominal
|
|||
|
TG
30870-irnt |
Triglycerides (IRNT) Triglycerides (quantile); Field 30870, IRNT |
MGI | C+T (GT) | UK Biobank GWAS | 13680 | 4.8e-240 | 0.0776 | 2947.5095 | 0.804 Beta 95% CI: 0.6633-0.9447 |
Quantitative
nominal
|
|||
|
T2D
29358691-GCST005413 |
Type 2 diabetes T2D |
UKB | C+T (DS) | Large GWAS | 118 | 1.9e-239 | 0.0164 | 0.0449 | 0.0449 | 0.594 0.588-0.6 |
2.45 OR 95% CI: 2.22-2.71 |
Binary
nominal
|
|
|
TG
30870-irnt |
Triglycerides (IRNT) Triglycerides (quantile); Field 30870, IRNT |
MGI | C+T (DS) | UK Biobank GWAS | 9693 | 1.2e-228 | 0.0777 | 2962.054 | 0.821 Beta 95% CI: 0.6801-0.9619 |
Quantitative
nominal
|
|||
|
TG
30870-raw |
Triglycerides (mmol/L) Field 30870, raw |
MGI | C+T (DS) | UK Biobank GWAS | 5113 | 1.4e-227 | 0.0749 | 2963.4295 | 0.878 Beta 95% CI: 0.7371-1.0189 |
Quantitative
nominal
|
|||
|
T2D
29358691-GCST005413 |
Type 2 diabetes T2D |
UKB | C+T (GT) | Large GWAS | 143 | 1.9e-227 | 0.0156 | 0.045 | 0.045 | 0.59 0.584-0.596 |
2.35 OR 95% CI: 2.12-2.6 |
Binary
nominal
|
|
|
TG
30870-raw |
Triglycerides (mmol/L) Field 30870, raw |
MGI | C+T (GT) | UK Biobank GWAS | 6730 | 5.5e-226 | 0.0741 | 2965.4833 | 0.838 Beta 95% CI: 0.6971-0.9789 |
Quantitative
nominal
|
|||
|
Menarche Age
ieu-a-1095 |
Age at menarche |
UKB | lassosum | Large GWAS | 137734 | 1.3e-223 | 0.008 | 7.6307 | 0.0655 Beta 95% CI: -0.0192-0.1502 |
Quantitative
nominal
|
|||
|
HTN
20002-1065 |
Self-reported hypertension |
MGI | PRS-CS | UK Biobank GWAS | 1113832 | 6.4e-213 | 0.0393 | 0.182 | 0.1825 | 0.63 0.622-0.639 |
3.99 OR 95% CI: 3.16-5.03 |
Binary
nominal
|
|
|
HTN
20002-1065 |
Self-reported hypertension |
MGI | lassosum | UK Biobank GWAS | 724579 | 6.9e-203 | 0.0359 | 0.183 | 0.1829 | 0.628 0.62-0.636 |
3.38 OR 95% CI: 2.69-4.23 |
Binary
nominal
|
|
|
SBP
4080-irnt |
Systolic blood pressure, automated (IRNT) Systolic blood pressure, automated reading; Field 4080, IRNT |
MGI | PRS-CS | UK Biobank GWAS | 1113831 | 1.7e-189 | 0.0306 | 138.5074 | 0.41 Beta 95% CI: 0.3247-0.4953 |
Quantitative
nominal
|
|||
|
Creatinine
30700-irnt |
Creatinine (IRNT) Creatinine (quantile); Field 30700, IRNT |
MGI | PRS-CS | UK Biobank GWAS | 1113831 | 4.6e-189 | 0.0288 | 0.0379 | 0.474 Beta 95% CI: 0.3895-0.5585 |
Quantitative
nominal
|
|||
|
SBP
4080-raw |
Systolic blood pressure, automated reading; Field 4080, raw |
MGI | PRS-CS | UK Biobank GWAS | 1113831 | 2.1e-186 | 0.0294 | 138.5895 | 0.437 Beta 95% CI: 0.3517-0.5223 |
Quantitative
nominal
|
|||
|
FPG
MAGIC-FastingGlucose |
Fasting plasma glucose Fast Plasma glucose |
UKB | lassosum | Large GWAS | 72352 | 4.1e-185 | 0.0047 | 1.444 | 0.366 Beta 95% CI: 0.2696-0.4624 |
Quantitative
nominal
|
|||
|
SBP
4080-irnt |
Systolic blood pressure, automated (IRNT) Systolic blood pressure, automated reading; Field 4080, IRNT |
MGI | lassosum | UK Biobank GWAS | 775138 | 1.6e-177 | 0.0282 | 138.8265 | 0.406 Beta 95% CI: 0.3209-0.4911 |
Quantitative
nominal
|
|||
|
FPG
MAGIC-FastingGlucose |
Fasting plasma glucose Fast Plasma glucose |
UKB | PRS-CS | Large GWAS | 1008035 | 5.4e-176 | 0.0047 | 1.4444 | 0.619 Beta 95% CI: 0.5302-0.7078 |
Quantitative
nominal
|
|||
|
eGFRcys
eGFRcys-overall-EA |
Estimated glomerular filtration rate based on cystatin C eGFRcys |
UKB | PRS-CS | Large GWAS | 16685 | 3.3e-175 | 0.004 | 0.0251 | -0.136 Beta 95% CI: -0.1654--0.1066 |
Quantitative
nominal
reversed effect
|
|||
|
LDL-C
30780-raw |
Direct LDL cholesterol (mmol/L) LDL direct (mmol/L); Field 30780, raw |
MGI | DBSLMM | UK Biobank GWAS | 8918470 | 4.1e-174 | 0.0758 | 724.2641 | 0.645 Beta 95% CI: 0.5033-0.7867 |
Quantitative
nominal
|
|||
|
SBP
4080-raw |
Systolic blood pressure, automated reading; Field 4080, raw |
MGI | lassosum | UK Biobank GWAS | 730914 | 1.4e-172 | 0.0265 | 138.9588 | 0.437 Beta 95% CI: 0.3519-0.5221 |
Quantitative
nominal
|
|||
|
FPG
MAGIC-FastingGlucose |
Fasting plasma glucose Fast Plasma glucose |
UKB | C+T (DS) | Large GWAS | 38 | 1.2e-171 | 0.0045 | 1.4445 | 0.445 Beta 95% CI: 0.3515-0.5385 |
Quantitative
nominal
|
|||
|
FPG
MAGIC-FastingGlucose |
Fasting plasma glucose Fast Plasma glucose |
UKB | C+T (GT) | Large GWAS | 38 | 1.2e-171 | 0.0045 | 1.4445 | 0.445 Beta 95% CI: 0.3515-0.5385 |
Quantitative
nominal
|
|||
|
Creatinine
30700-irnt |
Creatinine (IRNT) Creatinine (quantile); Field 30700, IRNT |
MGI | lassosum | UK Biobank GWAS | 828634 | 9.4e-171 | 0.0259 | 0.038 | 0.484 Beta 95% CI: 0.3997-0.5683 |
Quantitative
nominal
|
|||
|
Smoking
SmokingInitiation |
Smoking initiation SmokingInitiation |
MGI | PRS-CS | Large GWAS | 1109786 | 1.1e-170 | 0.044 | 0.232 | 0.2318 | 0.605 0.598-0.612 |
3.13 OR 95% CI: 2.54-3.87 |
Binary
nominal
|
|
|
DBP
4079-raw |
Diastolic blood pressure, automated reading; Field 4079, raw |
MGI | PRS-CS | UK Biobank GWAS | 1113831 | 4.8e-170 | 0.0293 | 45.1288 | 0.422 Beta 95% CI: 0.3338-0.5102 |
Quantitative
nominal
|
|||
|
DBP
4079-irnt |
Diastolic blood pressure, automated (IRNT) Diastolic blood pressure, automated reading; Field 4079, IRNT |
MGI | PRS-CS | UK Biobank GWAS | 1113831 | 1.8e-169 | 0.0296 | 45.1339 | 0.386 Beta 95% CI: 0.2976-0.4744 |
Quantitative
nominal
|
|||
|
TC
30690-irnt |
Total cholesterol (IRNT) Cholesterol (quantile); Field 30690, IRNT |
MGI | PRS-CS | UK Biobank GWAS | 1113831 | 3.2e-168 | 0.0694 | 1002.6421 | 0.731 Beta 95% CI: 0.5907-0.8713 |
Quantitative
nominal
|
|||
|
Smoking
SmokingInitiation |
Smoking initiation SmokingInitiation |
MGI | lassosum | Large GWAS | 641463 | 1.6e-167 | 0.0448 | 0.232 | 0.232 | 0.604 0.597-0.611 |
3.15 OR 95% CI: 2.55-3.9 |
Binary
nominal
|
|
|
TC
30690-raw |
Total cholesterol (mmol/L) Cholesterol (mmol/L); Field 30690, raw |
MGI | PRS-CS | UK Biobank GWAS | 1113831 | 1.1e-165 | 0.071 | 1003.8282 | 0.656 Beta 95% CI: 0.5157-0.7963 |
Quantitative
nominal
|
|||
|
Creatinine
30700-raw |
Creatinine (umol/L) Field 30700, raw |
MGI | PRS-CS | UK Biobank GWAS | 1113831 | 3.5e-162 | 0.0245 | 0.0381 | 0.421 Beta 95% CI: 0.3365-0.5055 |
Quantitative
nominal
|
|||
|
HTN
20002-1065 |
Self-reported hypertension |
MGI | C+T (DS) | UK Biobank GWAS | 26671 | 3.4e-160 | 0.0294 | 0.185 | 0.185 | 0.612 0.603-0.62 |
3.08 OR 95% CI: 2.46-3.86 |
Binary
nominal
|
|
|
T2D
30054458-GCST006867 |
Type 2 diabetes T2D |
MGI | PRS-CS | Large GWAS | 945820 | 1.1e-159 | 0.0561 | 0.139 | 0.1389 | 0.637 0.621-0.653 |
3.29 OR 95% CI: 2.65-4.08 |
Binary
nominal
|
|
|
LDL-C
30780-irnt |
Direct LDL cholesterol (IRNT) LDL direct (quantile); Field 30780, IRNT |
MGI | DBSLMM | UK Biobank GWAS | 7457930 | 1.9e-159 | 0.0676 | 729.1461 | 0.515 Beta 95% CI: 0.3731-0.6569 |
Quantitative
nominal
|
|||
|
HTN
20002-1065 |
Self-reported hypertension |
MGI | C+T (GT) | UK Biobank GWAS | 25909 | 1.7e-157 | 0.0289 | 0.185 | 0.1851 | 0.611 0.602-0.619 |
2.97 OR 95% CI: 2.38-3.72 |
Binary
nominal
|
|
|
SBP
4080-irnt |
Systolic blood pressure, automated (IRNT) Systolic blood pressure, automated reading; Field 4080, IRNT |
MGI | C+T (DS) | UK Biobank GWAS | 24765 | 3.3e-155 | 0.0217 | 139.4262 | 0.438 Beta 95% CI: 0.3527-0.5233 |
Quantitative
nominal
|
|||
|
DBP
4079-raw |
Diastolic blood pressure, automated reading; Field 4079, raw |
MGI | lassosum | UK Biobank GWAS | 749859 | 2.6e-152 | 0.0272 | 45.2838 | 0.426 Beta 95% CI: 0.3378-0.5142 |
Quantitative
nominal
|
|||
|
TC
30690-raw |
Total cholesterol (mmol/L) Cholesterol (mmol/L); Field 30690, raw |
MGI | DBSLMM | UK Biobank GWAS | 7459288 | 4.9e-152 | 0.0631 | 1010.2625 | 0.524 Beta 95% CI: 0.3837-0.6643 |
Quantitative
nominal
|
|||
|
TC
30690-irnt |
Total cholesterol (IRNT) Cholesterol (quantile); Field 30690, IRNT |
MGI | DBSLMM | UK Biobank GWAS | 7459292 | 3.4e-151 | 0.0628 | 1010.6633 | 0.58 Beta 95% CI: 0.4397-0.7203 |
Quantitative
nominal
|
|||
|
eGFR
20171017-MW-eGFR-EA |
Estimated glomerular filtration rate eGFR |
MGI | PRS-CS | Large GWAS | 1117334 | 3.8e-150 | 0.0226 | 289.7595 | 0.28 Beta 95% CI: 0.2014-0.3586 |
Quantitative
nominal
|
|||
|
SBP
4080-raw |
Systolic blood pressure, automated reading; Field 4080, raw |
MGI | C+T (DS) | UK Biobank GWAS | 16283 | 5.4e-150 | 0.0198 | 139.5671 | 0.422 Beta 95% CI: 0.3367-0.5073 |
Quantitative
nominal
|
|||
|
DBP
4079-irnt |
Diastolic blood pressure, automated (IRNT) Diastolic blood pressure, automated reading; Field 4079, IRNT |
MGI | lassosum | UK Biobank GWAS | 755822 | 1.1e-149 | 0.0272 | 45.3069 | 0.416 Beta 95% CI: 0.3278-0.5042 |
Quantitative
nominal
|
|||
|
LDL-C
30780-raw |
Direct LDL cholesterol (mmol/L) LDL direct (mmol/L); Field 30780, raw |
MGI | PRS-CS | UK Biobank GWAS | 1113830 | 1.9e-149 | 0.0703 | 732.515 | 0.662 Beta 95% CI: 0.5203-0.8037 |
Quantitative
nominal
|
|||
|
TC
30690-raw |
Total cholesterol (mmol/L) Cholesterol (mmol/L); Field 30690, raw |
MGI | C+T (GT) | UK Biobank GWAS | 3604 | 4.6e-149 | 0.0606 | 1011.674 | 0.627 Beta 95% CI: 0.4867-0.7673 |
Quantitative
nominal
|
|||
|
TC
30690-irnt |
Total cholesterol (IRNT) Cholesterol (quantile); Field 30690, IRNT |
MGI | C+T (GT) | UK Biobank GWAS | 3566 | 8.9e-149 | 0.0604 | 1011.81 | 0.63 Beta 95% CI: 0.4897-0.7703 |
Quantitative
nominal
|
|||
|
TC
30690-irnt |
Total cholesterol (IRNT) Cholesterol (quantile); Field 30690, IRNT |
MGI | lassosum | UK Biobank GWAS | 585328 | 3.6e-148 | 0.0571 | 1012.1003 | 0.593 Beta 95% CI: 0.4525-0.7335 |
Quantitative
nominal
|
|||
|
LDL-C
30780-irnt |
Direct LDL cholesterol (IRNT) LDL direct (quantile); Field 30780, IRNT |
MGI | PRS-CS | UK Biobank GWAS | 1113830 | 1.2e-147 | 0.0705 | 733.1237 | 0.715 Beta 95% CI: 0.5733-0.8567 |
Quantitative
nominal
|
|||
|
T2D
30054458-GCST006867 |
Type 2 diabetes T2D |
MGI | lassosum | Large GWAS | 555512 | 4.1e-147 | 0.0535 | 0.139 | 0.1394 | 0.626 0.609-0.641 |
3.54 OR 95% CI: 2.87-4.36 |
Binary
nominal
|
|
|
Creatinine
30700-irnt |
Creatinine (IRNT) Creatinine (quantile); Field 30700, IRNT |
MGI | C+T (DS) | UK Biobank GWAS | 19120 | 2.5e-146 | 0.0224 | 0.0382 | 0.457 Beta 95% CI: 0.3727-0.5413 |
Quantitative
nominal
|
|||
|
Creatinine
30700-irnt |
Creatinine (IRNT) Creatinine (quantile); Field 30700, IRNT |
MGI | DBSLMM | UK Biobank GWAS | 7451744 | 7.3e-145 | 0.0205 | 0.0383 | 0.4 Beta 95% CI: 0.3157-0.4843 |
Quantitative
nominal
|
|||
|
eGFR
20171017-MW-eGFR-EA |
Estimated glomerular filtration rate eGFR |
MGI | lassosum | Large GWAS | 443281 | 2.5e-144 | 0.0212 | 290.1442 | 0.275 Beta 95% CI: 0.1964-0.3536 |
Quantitative
nominal
|
|||
|
LDL-C
30780-irnt |
Direct LDL cholesterol (IRNT) LDL direct (quantile); Field 30780, IRNT |
MGI | C+T (GT) | UK Biobank GWAS | 2609 | 2.8e-144 | 0.0644 | 734.2699 | 0.525 Beta 95% CI: 0.3831-0.6669 |
Quantitative
nominal
|
|||
|
TC
30690-raw |
Total cholesterol (mmol/L) Cholesterol (mmol/L); Field 30690, raw |
MGI | lassosum | UK Biobank GWAS | 569518 | 7.1e-144 | 0.0562 | 1014.1476 | 0.617 Beta 95% CI: 0.4765-0.7575 |
Quantitative
nominal
|
|||
|
TC
30690-raw |
Total cholesterol (mmol/L) Cholesterol (mmol/L); Field 30690, raw |
MGI | C+T (DS) | UK Biobank GWAS | 2863 | 1.6e-143 | 0.0577 | 1014.3114 | 0.63 Beta 95% CI: 0.4897-0.7703 |
Quantitative
nominal
|
|||
|
SBP
4080-irnt |
Systolic blood pressure, automated (IRNT) Systolic blood pressure, automated reading; Field 4080, IRNT |
MGI | DBSLMM | UK Biobank GWAS | 7477086 | 4e-143 | 0.0233 | 139.753 | 0.29 Beta 95% CI: 0.2047-0.3753 |
Quantitative
nominal
|
|||
|
TC
30690-irnt |
Total cholesterol (IRNT) Cholesterol (quantile); Field 30690, IRNT |
MGI | C+T (DS) | UK Biobank GWAS | 2822 | 4.5e-143 | 0.0575 | 1014.5333 | 0.655 Beta 95% CI: 0.5147-0.7953 |
Quantitative
nominal
|
|||
|
LDL-C
30780-raw |
Direct LDL cholesterol (mmol/L) LDL direct (mmol/L); Field 30780, raw |
MGI | C+T (GT) | UK Biobank GWAS | 2935 | 6.5e-142 | 0.0647 | 735.0761 | 0.518 Beta 95% CI: 0.3761-0.6599 |
Quantitative
nominal
|
|||
|
Creatinine
30700-irnt |
Creatinine (IRNT) Creatinine (quantile); Field 30700, IRNT |
MGI | C+T (GT) | UK Biobank GWAS | 29361 | 8.1e-141 | 0.0201 | 0.0383 | 0.486 Beta 95% CI: 0.4017-0.5703 |
Quantitative
nominal
|
|||
|
T2D
30054458-GCST006867 |
Type 2 diabetes T2D |
MGI | DBSLMM | Large GWAS | 5052574 | 1.5e-139 | 0.0483 | 0.14 | 0.1397 | 0.628 0.611-0.643 |
3.62 OR 95% CI: 2.93-4.48 |
Binary
nominal
|
|
|
LDL-C
30780-raw |
Direct LDL cholesterol (mmol/L) LDL direct (mmol/L); Field 30780, raw |
MGI | C+T (DS) | UK Biobank GWAS | 2288 | 6.9e-139 | 0.0624 | 736.1087 | 0.581 Beta 95% CI: 0.4391-0.7229 |
Quantitative
nominal
|
|||
|
LDL-C
30780-irnt |
Direct LDL cholesterol (IRNT) LDL direct (quantile); Field 30780, IRNT |
MGI | C+T (DS) | UK Biobank GWAS | 2066 | 5.7e-138 | 0.0622 | 736.4222 | 0.532 Beta 95% CI: 0.3901-0.6739 |
Quantitative
nominal
|
|||
|
SBP
4080-raw |
Systolic blood pressure, automated reading; Field 4080, raw |
MGI | DBSLMM | UK Biobank GWAS | 7477072 | 8.1e-137 | 0.023 | 139.9242 | 0.373 Beta 95% CI: 0.2877-0.4583 |
Quantitative
nominal
|
|||
|
LDL-C
30780-raw |
Direct LDL cholesterol (mmol/L) LDL direct (mmol/L); Field 30780, raw |
MGI | lassosum | UK Biobank GWAS | 552845 | 1e-134 | 0.0611 | 737.5395 | 0.562 Beta 95% CI: 0.4201-0.7039 |
Quantitative
nominal
|
|||
|
LDL-C
30780-irnt |
Direct LDL cholesterol (IRNT) LDL direct (quantile); Field 30780, IRNT |
MGI | lassosum | UK Biobank GWAS | 549112 | 1.3e-134 | 0.061 | 737.5697 | 0.599 Beta 95% CI: 0.4571-0.7409 |
Quantitative
nominal
|
|||
|
Creatinine
30700-raw |
Creatinine (umol/L) Field 30700, raw |
MGI | lassosum | UK Biobank GWAS | 638561 | 1.7e-133 | 0.0209 | 0.0384 | 0.453 Beta 95% CI: 0.3687-0.5373 |
Quantitative
nominal
|
|||
|
Smoking
SmokingInitiation |
Smoking initiation SmokingInitiation |
MGI | C+T (DS) | Large GWAS | 8148 | 7.1e-125 | 0.035 | 0.234 | 0.2342 | 0.59 0.582-0.597 |
2.72 OR 95% CI: 2.22-3.33 |
Binary
nominal
|
|
|
DBP
4079-raw |
Diastolic blood pressure, automated reading; Field 4079, raw |
MGI | C+T (DS) | UK Biobank GWAS | 15687 | 1.8e-124 | 0.0227 | 45.5291 | 0.36 Beta 95% CI: 0.2716-0.4484 |
Quantitative
nominal
|
|||
|
T2D
2443 |
Doctor-diagnosed diabetes Diabetes diagnosed by doctor |
MGI | PRS-CS | UK Biobank GWAS | 1113832 | 1.4e-123 | 0.0454 | 0.141 | 0.1406 | 0.625 0.608-0.639 |
2.59 OR 95% CI: 2.08-3.22 |
Binary
nominal
|
|
|
DBP
4079-irnt |
Diastolic blood pressure, automated (IRNT) Diastolic blood pressure, automated reading; Field 4079, IRNT |
MGI | C+T (DS) | UK Biobank GWAS | 24016 | 5.6e-120 | 0.0229 | 45.5689 | 0.444 Beta 95% CI: 0.3558-0.5322 |
Quantitative
nominal
|
|||
|
T2D
METAANALYSIS-DIAGRAM |
Type 2 diabetes T2D |
MGI | PRS-CS | Large GWAS | 1118480 | 2e-115 | 0.0296 | 0.141 | 0.1408 | 0.61 0.594-0.625 |
3.28 OR 95% CI: 2.63-4.07 |
Binary
nominal
|
|
|
DBP
4079-irnt |
Diastolic blood pressure, automated (IRNT) Diastolic blood pressure, automated reading; Field 4079, IRNT |
MGI | DBSLMM | UK Biobank GWAS | 7477069 | 7e-113 | 0.0234 | 45.632 | 0.29 Beta 95% CI: 0.2018-0.3782 |
Quantitative
nominal
|
|||
|
Glucose
30740-raw |
Glucose (mmol/L) Field 30740, raw |
MGI | PRS-CS | UK Biobank GWAS | 1113830 | 8.4e-112 | 0.0196 | 304.4734 | 0.358 Beta 95% CI: 0.2671-0.4489 |
Quantitative
nominal
|
|||
|
DBP
4079-raw |
Diastolic blood pressure, automated reading; Field 4079, raw |
MGI | C+T (GT) | UK Biobank GWAS | 24976 | 1.8e-111 | 0.021 | 45.6446 | 0.313 Beta 95% CI: 0.2244-0.4016 |
Quantitative
nominal
|
|||
|
DBP
4079-irnt |
Diastolic blood pressure, automated (IRNT) Diastolic blood pressure, automated reading; Field 4079, IRNT |
MGI | C+T (GT) | UK Biobank GWAS | 40911 | 7.9e-111 | 0.0206 | 45.6503 | 0.317 Beta 95% CI: 0.2284-0.4056 |
Quantitative
nominal
|
|||
|
SBP
4080-irnt |
Systolic blood pressure, automated (IRNT) Systolic blood pressure, automated reading; Field 4080, IRNT |
MGI | C+T (GT) | UK Biobank GWAS | 41867 | 8.6e-111 | 0.0195 | 140.6348 | 0.28 Beta 95% CI: 0.1947-0.3653 |
Quantitative
nominal
|
|||
|
DBP
4079-raw |
Diastolic blood pressure, automated reading; Field 4079, raw |
MGI | DBSLMM | UK Biobank GWAS | 7259551 | 1.4e-110 | 0.0238 | 45.6525 | 0.327 Beta 95% CI: 0.2388-0.4152 |
Quantitative
nominal
|
|||
|
SBP
4080-raw |
Systolic blood pressure, automated reading; Field 4080, raw |
MGI | C+T (GT) | UK Biobank GWAS | 25673 | 1.5e-109 | 0.0191 | 140.6686 | 0.337 Beta 95% CI: 0.2517-0.4223 |
Quantitative
nominal
|
|||
|
eGFRcr
eGFRcrea-overall-IV-2GC |
Estimated glomerular filtration rate based on creatinine eGFRcrea |
MGI | PRS-CS | Large GWAS | 932548 | 3.3e-109 | 0.0154 | 0.0386 | -0.343 Beta 95% CI: -0.4273--0.2587 |
Quantitative
nominal
reversed effect
|
|||
|
Creatinine
30700-raw |
Creatinine (umol/L) Field 30700, raw |
MGI | C+T (DS) | UK Biobank GWAS | 3503 | 1.5e-108 | 0.0184 | 0.0386 | 0.447 Beta 95% CI: 0.3627-0.5313 |
Quantitative
nominal
|
|||
|
T2D
2443 |
Doctor-diagnosed diabetes Diabetes diagnosed by doctor |
MGI | lassosum | UK Biobank GWAS | 488969 | 9.2e-108 | 0.0401 | 0.141 | 0.1413 | 0.616 0.6-0.63 |
2.64 OR 95% CI: 2.13-3.28 |
Binary
nominal
|
|
|
T2D
METAANALYSIS-DIAGRAM |
Type 2 diabetes T2D |
MGI | lassosum | Large GWAS | 374510 | 1e-107 | 0.0275 | 0.141 | 0.1411 | 0.611 0.595-0.626 |
2.92 OR 95% CI: 2.35-3.63 |
Binary
nominal
|
|
|
T2D
30054458-GCST006867 |
Type 2 diabetes T2D |
MGI | C+T (DS) | Large GWAS | 5693 | 1.6e-107 | 0.0369 | 0.141 | 0.1411 | 0.6 0.585-0.616 |
2.7 OR 95% CI: 2.18-3.35 |
Binary
nominal
|
|
|
T2D
30054458-GCST006867 |
Type 2 diabetes T2D |
MGI | C+T (GT) | Large GWAS | 5693 | 1.6e-107 | 0.0369 | 0.141 | 0.1411 | 0.6 0.585-0.616 |
2.7 OR 95% CI: 2.18-3.35 |
Binary
nominal
|
|
|
eGFRcr
CKDGen-1000Genomes-DiscoveryMeta-eGFRcrea |
Estimated glomerular filtration rate based on creatinine eGFRcrea |
MGI | PRS-CS | Large GWAS | 1109085 | 4e-107 | 0.0154 | 0.0386 | 0.289 Beta 95% CI: 0.2041-0.3739 |
Quantitative
nominal
|
|||
|
eGFRcr
eGFRcrea-overall-IV-2GC |
Estimated glomerular filtration rate based on creatinine eGFRcrea |
MGI | lassosum | Large GWAS | 87064 | 2.8e-106 | 0.014 | 0.0386 | -0.315 Beta 95% CI: -0.3991--0.2309 |
Quantitative
nominal
reversed effect
|
|||
|
eGFR
20171017-MW-eGFR-EA |
Estimated glomerular filtration rate eGFR |
MGI | DBSLMM | Large GWAS | 4656243 | 9.8e-106 | 0.0183 | 292.7222 | 0.245 Beta 95% CI: 0.1664-0.3236 |
Quantitative
nominal
|
|||
|
Creatinine
30700-raw |
Creatinine (umol/L) Field 30700, raw |
MGI | DBSLMM | UK Biobank GWAS | 7451626 | 4e-104 | 0.0136 | 0.0386 | 0.347 Beta 95% CI: 0.2629-0.4311 |
Quantitative
nominal
|
|||
|
Smoking
20160 |
Ever smoked |
MGI | PRS-CS | UK Biobank GWAS | 1113832 | 1.9e-103 | 0.0241 | 0.235 | 0.2353 | 0.583 0.575-0.591 |
2.02 OR 95% CI: 1.66-2.45 |
Binary
nominal
|
|
|
eGFR
20171017-MW-eGFR-EA |
Estimated glomerular filtration rate eGFR |
MGI | C+T (GT) | Large GWAS | 2491 | 7.2e-97 | 0.0165 | 293.3206 | 0.254 Beta 95% CI: 0.1754-0.3326 |
Quantitative
nominal
|
|||
|
eGFRcr
CKDGen-1000Genomes-DiscoveryMeta-eGFRcrea |
Estimated glomerular filtration rate based on creatinine eGFRcrea |
MGI | lassosum | Large GWAS | 202159 | 9.6e-97 | 0.0137 | 0.0387 | 0.32 Beta 95% CI: 0.2357-0.4043 |
Quantitative
nominal
|
|||
|
eGFR
20171017-MW-eGFR-EA |
Estimated glomerular filtration rate eGFR |
MGI | C+T (DS) | Large GWAS | 2439 | 3.4e-96 | 0.0162 | 293.3665 | 0.253 Beta 95% CI: 0.1744-0.3316 |
Quantitative
nominal
|
|||
|
Glucose
30740-irnt |
Glucose (IRNT) Glucose (quantile); Field 30740, IRNT |
MGI | PRS-CS | UK Biobank GWAS | 1113830 | 1.5e-91 | 0.0178 | 305.8356 | 0.368 Beta 95% CI: 0.2782-0.4578 |
Quantitative
nominal
|
|||
|
Glucose
30740-irnt |
Glucose (IRNT) Glucose (quantile); Field 30740, IRNT |
MGI | lassosum | UK Biobank GWAS | 513495 | 5.4e-90 | 0.017 | 305.9408 | 0.353 Beta 95% CI: 0.2632-0.4428 |
Quantitative
nominal
|
|||
|
Height
ieu-a-89 |
Height |
MGI | DBSLMM | Large GWAS | 912901 | 5.6e-90 | 0.0111 | 45.536 | 0.282 Beta 95% CI: 0.2207-0.3433 |
Quantitative
nominal
|
|||
|
Smoking
20160 |
Ever smoked |
MGI | lassosum | UK Biobank GWAS | 595975 | 1.2e-88 | 0.0191 | 0.237 | 0.2365 | 0.577 0.57-0.584 |
1.95 OR 95% CI: 1.61-2.37 |
Binary
nominal
|
|
|
Smoking
SmokingInitiation |
Smoking initiation SmokingInitiation |
MGI | C+T (GT) | Large GWAS | 15848 | 2.6e-88 | 0.0266 | 0.236 | 0.236 | 0.576 0.568-0.583 |
2.02 OR 95% CI: 1.66-2.45 |
Binary
nominal
|
|
|
Glucose
30740-raw |
Glucose (mmol/L) Field 30740, raw |
MGI | lassosum | UK Biobank GWAS | 444825 | 4.5e-84 | 0.0185 | 306.3415 | 0.331 Beta 95% CI: 0.2403-0.4217 |
Quantitative
nominal
|
|||
|
Smoking
20116-1 |
Previous smoker Smoking status: Previous |
MGI | PRS-CS | UK Biobank GWAS | 1113832 | 4.9e-81 | 0.018 | 0.236 | 0.2364 | 0.573 0.565-0.579 |
2.03 OR 95% CI: 1.67-2.46 |
Binary
nominal
|
|
|
HTN
20002-1065 |
Self-reported hypertension |
MGI | DBSLMM | UK Biobank GWAS | 7601215 | 1.1e-80 | 0.0136 | 0.189 | 0.1886 | 0.58 0.572-0.59 |
2.19 OR 95% CI: 1.77-2.72 |
Binary
nominal
|
|
|
Menarche Age
ieu-a-1095 |
Age at menarche |
UKB | DBSLMM | Large GWAS | 991712 | 1.5e-80 | 0.003 | 7.6761 | 0.0079 Beta 95% CI: -0.0771-0.093 |
Quantitative
nominal
|
|||
|
T2D
2443 |
Doctor-diagnosed diabetes Diabetes diagnosed by doctor |
MGI | C+T (DS) | UK Biobank GWAS | 1888 | 9.4e-77 | 0.0299 | 0.143 | 0.1425 | 0.599 0.582-0.615 |
2.31 OR 95% CI: 1.85-2.88 |
Binary
nominal
|
|
|
Creatinine
30700-raw |
Creatinine (umol/L) Field 30700, raw |
MGI | C+T (GT) | UK Biobank GWAS | 6012 | 1.8e-76 | 0.0133 | 0.0388 | 0.311 Beta 95% CI: 0.2269-0.3951 |
Quantitative
nominal
|
|||
|
Glucose
30740-irnt |
Glucose (IRNT) Glucose (quantile); Field 30740, IRNT |
MGI | C+T (DS) | UK Biobank GWAS | 4535 | 2.1e-76 | 0.014 | 306.8615 | 0.343 Beta 95% CI: 0.2534-0.4326 |
Quantitative
nominal
|
|||
|
Glucose
30740-irnt |
Glucose (IRNT) Glucose (quantile); Field 30740, IRNT |
MGI | C+T (GT) | UK Biobank GWAS | 4405 | 3.2e-74 | 0.014 | 307.0098 | 0.304 Beta 95% CI: 0.2144-0.3936 |
Quantitative
nominal
|
|||
|
eGFRcr
eGFRcrea-overall-IV-2GC |
Estimated glomerular filtration rate based on creatinine eGFRcrea |
MGI | C+T (DS) | Large GWAS | 234 | 1.2e-65 | 0.0106 | 0.0389 | -0.243 Beta 95% CI: -0.3271--0.1589 |
Quantitative
nominal
reversed effect
|
|||
|
eGFRcr
eGFRcrea-overall-IV-2GC |
Estimated glomerular filtration rate based on creatinine eGFRcrea |
MGI | C+T (GT) | Large GWAS | 234 | 1.2e-65 | 0.0106 | 0.0389 | -0.243 Beta 95% CI: -0.3271--0.1589 |
Quantitative
nominal
reversed effect
|
|||
|
T2D
2443 |
Doctor-diagnosed diabetes Diabetes diagnosed by doctor |
MGI | C+T (GT) | UK Biobank GWAS | 2707 | 6.3e-65 | 0.0255 | 0.143 | 0.1429 | 0.591 0.574-0.606 |
1.92 OR 95% CI: 1.53-2.41 |
Binary
nominal
|
|
|
eGFRcr
eGFRcrea-overall-IV-2GC |
Estimated glomerular filtration rate based on creatinine eGFRcrea |
MGI | DBSLMM | Large GWAS | 1005540 | 7.8e-64 | 0.0115 | 0.0389 | -0.295 Beta 95% CI: -0.3791--0.2109 |
Quantitative
nominal
reversed effect
|
|||
|
eGFRcr
eGFRcrea-overall-EA |
Estimated glomerular filtration rate based on creatinine eGFRcrea |
MGI | lassosum | Large GWAS | 2986 | 7.9e-63 | 0.0109 | 0.039 | -0.133 Beta 95% CI: -0.2173--0.0487 |
Quantitative
nominal
reversed effect
|
|||
|
Glucose
30740-raw |
Glucose (mmol/L) Field 30740, raw |
MGI | C+T (GT) | UK Biobank GWAS | 1049 | 1.5e-62 | 0.0171 | 307.8068 | 0.223 Beta 95% CI: 0.1328-0.3132 |
Quantitative
nominal
|
|||
|
T2D
29358691-GCST005413 |
Type 2 diabetes T2D |
MGI | PRS-CS | Large GWAS | 1116101 | 1.8e-62 | 0.0223 | 0.143 | 0.1429 | 0.593 0.577-0.608 |
2.32 OR 95% CI: 1.87-2.89 |
Binary
nominal
|
|
|
Smoking
20116-1 |
Previous smoker Smoking status: Previous |
MGI | lassosum | UK Biobank GWAS | 520707 | 7.9e-62 | 0.0133 | 0.237 | 0.2371 | 0.565 0.557-0.572 |
1.5 OR 95% CI: 1.25-1.82 |
Binary
nominal
|
|
|
Glucose
30740-raw |
Glucose (mmol/L) Field 30740, raw |
MGI | C+T (DS) | UK Biobank GWAS | 1080 | 3.8e-61 | 0.0176 | 307.9022 | 0.243 Beta 95% CI: 0.153-0.333 |
Quantitative
nominal
|
|||
|
Menopause Age
ieu-a-1004 |
Age at menopause |
UKB | C+T (DS) | Large GWAS | 159 | 3.6e-57 | 0.004 | 178.0325 | 0.189 Beta 95% CI: 0.1365-0.2415 |
Quantitative
nominal
|
|||
|
Menopause Age
ieu-a-1004 |
Age at menopause |
UKB | C+T (GT) | Large GWAS | 159 | 3.6e-57 | 0.004 | 178.0325 | 0.189 Beta 95% CI: 0.1365-0.2415 |
Quantitative
nominal
|
|||
|
eGFRcr
CKDGen-1000Genomes-DiscoveryMeta-eGFRcrea |
Estimated glomerular filtration rate based on creatinine eGFRcrea |
MGI | C+T (DS) | Large GWAS | 108 | 1.1e-55 | 0.0109 | 0.039 | 0.321 Beta 95% CI: 0.2369-0.4051 |
Quantitative
nominal
|
|||
|
eGFRcr
CKDGen-1000Genomes-DiscoveryMeta-eGFRcrea |
Estimated glomerular filtration rate based on creatinine eGFRcrea |
MGI | C+T (GT) | Large GWAS | 108 | 1.1e-55 | 0.0109 | 0.039 | 0.321 Beta 95% CI: 0.2369-0.4051 |
Quantitative
nominal
|
|||
|
T2D
29358691-GCST005413 |
Type 2 diabetes T2D |
MGI | lassosum | Large GWAS | 266890 | 4e-55 | 0.0228 | 0.143 | 0.1432 | 0.589 0.572-0.604 |
2.54 OR 95% CI: 2.04-3.16 |
Binary
nominal
|
|
|
Smoking
20160 |
Ever smoked |
MGI | C+T (DS) | UK Biobank GWAS | 8787 | 5.4e-55 | 0.0143 | 0.238 | 0.2382 | 0.559 0.552-0.567 |
1.52 OR 95% CI: 1.26-1.84 |
Binary
nominal
|
|
|
Smoking
20160 |
Ever smoked |
MGI | DBSLMM | UK Biobank GWAS | 7433494 | 1.7e-54 | 0.012 | 0.238 | 0.2382 | 0.558 0.551-0.565 |
1.84 OR 95% CI: 1.52-2.22 |
Binary
nominal
|
|
|
T2D
METAANALYSIS-DIAGRAM |
Type 2 diabetes T2D |
MGI | C+T (DS) | Large GWAS | 187 | 5.1e-54 | 0.0183 | 0.143 | 0.1432 | 0.572 0.555-0.588 |
2.12 OR 95% CI: 1.69-2.64 |
Binary
nominal
|
|
|
T2D
METAANALYSIS-DIAGRAM |
Type 2 diabetes T2D |
MGI | C+T (GT) | Large GWAS | 187 | 5.1e-54 | 0.0183 | 0.143 | 0.1432 | 0.572 0.555-0.588 |
2.12 OR 95% CI: 1.69-2.64 |
Binary
nominal
|
|
|
eGFRcr
eGFRcrea-overall-EA |
Estimated glomerular filtration rate based on creatinine eGFRcrea |
MGI | C+T (DS) | Large GWAS | 352 | 7.7e-48 | 0.0094 | 0.0391 | -0.161 Beta 95% CI: -0.2451--0.0769 |
Quantitative
nominal
reversed effect
|
|||
|
Vit D
30890-raw |
Vitamin D (nmol/L) Field 30890, raw |
MGI | C+T (GT) | UK Biobank GWAS | 500 | 9e-46 | 0.0242 | 78.8307 | 0.399 Beta 95% CI: 0.2357-0.5623 |
Quantitative
nominal
|
|||
|
Smoking
20116-1 |
Previous smoker Smoking status: Previous |
MGI | C+T (DS) | UK Biobank GWAS | 14682 | 2.8e-45 | 0.0094 | 0.238 | 0.238 | 0.555 0.547-0.562 |
1.61 OR 95% CI: 1.33-1.94 |
Binary
nominal
|
|
|
Vit D
30890-irnt |
Vitamin D (IRNT) Vitamin D (quantile); Field 30890, IRNT |
MGI | lassosum | UK Biobank GWAS | 547654 | 3.3e-45 | 0.0254 | 78.8591 | 0.385 Beta 95% CI: 0.2219-0.5481 |
Quantitative
nominal
|
|||
|
eGFRcr
eGFRcrea-overall-EA |
Estimated glomerular filtration rate based on creatinine eGFRcrea |
MGI | C+T (GT) | Large GWAS | 641 | 1.6e-44 | 0.0086 | 0.0391 | -0.239 Beta 95% CI: -0.3231--0.1549 |
Quantitative
nominal
reversed effect
|
|||
|
Vit D
30890-raw |
Vitamin D (nmol/L) Field 30890, raw |
MGI | C+T (DS) | UK Biobank GWAS | 404 | 4e-44 | 0.0217 | 78.9146 | 0.29 Beta 95% CI: 0.1267-0.4533 |
Quantitative
nominal
|
|||
|
Smoking
20160 |
Ever smoked |
MGI | C+T (GT) | UK Biobank GWAS | 14184 | 7.3e-44 | 0.0108 | 0.239 | 0.2387 | 0.553 0.546-0.561 |
1.63 OR 95% CI: 1.35-1.98 |
Binary
nominal
|
|
|
Vit D
30890-raw |
Vitamin D (nmol/L) Field 30890, raw |
MGI | PRS-CS | UK Biobank GWAS | 1113831 | 1.8e-43 | 0.0285 | 78.9478 | 0.24 Beta 95% CI: 0.0767-0.4033 |
Quantitative
nominal
|
|||
|
Vit D
30890-irnt |
Vitamin D (IRNT) Vitamin D (quantile); Field 30890, IRNT |
MGI | C+T (GT) | UK Biobank GWAS | 605 | 3.7e-43 | 0.0242 | 78.9639 | 0.281 Beta 95% CI: 0.1177-0.4443 |
Quantitative
nominal
|
|||
|
Smoking
20116-1 |
Previous smoker Smoking status: Previous |
MGI | DBSLMM | UK Biobank GWAS | 7075957 | 1.1e-42 | 0.0077 | 0.238 | 0.2381 | 0.552 0.545-0.56 |
1.75 OR 95% CI: 1.45-2.12 |
Binary
nominal
|
|
|
Vit D
30890-irnt |
Vitamin D (IRNT) Vitamin D (quantile); Field 30890, IRNT |
MGI | PRS-CS | UK Biobank GWAS | 1113831 | 1.2e-42 | 0.0292 | 78.9895 | 0.229 Beta 95% CI: 0.0657-0.3923 |
Quantitative
nominal
|
|||
|
Vit D
30890-irnt |
Vitamin D (IRNT) Vitamin D (quantile); Field 30890, IRNT |
MGI | C+T (DS) | UK Biobank GWAS | 495 | 2.1e-41 | 0.0214 | 79.0534 | 0.249 Beta 95% CI: 0.0857-0.4123 |
Quantitative
nominal
|
|||
|
Glucose
30740-irnt |
Glucose (IRNT) Glucose (quantile); Field 30740, IRNT |
MGI | DBSLMM | UK Biobank GWAS | 7600988 | 2.5e-41 | 0.008 | 309.2626 | 0.257 Beta 95% CI: 0.1674-0.3466 |
Quantitative
nominal
|
|||
|
T2D
2443 |
Doctor-diagnosed diabetes Diabetes diagnosed by doctor |
MGI | DBSLMM | UK Biobank GWAS | 10304000 | 7.7e-40 | 0.0165 | 0.144 | 0.1439 | 0.563 0.546-0.58 |
1.41 OR 95% CI: 1.12-1.78 |
Binary
nominal
|
|
|
Vit D
30890-raw |
Vitamin D (nmol/L) Field 30890, raw |
MGI | lassosum | UK Biobank GWAS | 548161 | 2.2e-39 | 0.0265 | 79.1561 | 0.317 Beta 95% CI: 0.1539-0.4801 |
Quantitative
nominal
|
|||
|
Vit D
29343764-GCST005367 |
Vitamin D |
MGI | lassosum | Large GWAS | 108547 | 5.5e-38 | 0.0195 | 79.2279 | 0.355 Beta 95% CI: 0.1919-0.5181 |
Quantitative
nominal
|
|||
|
T2D
29358691-GCST005413 |
Type 2 diabetes T2D |
MGI | C+T (DS) | Large GWAS | 45 | 2.4e-32 | 0.0169 | 0.144 | 0.1442 | 0.562 0.546-0.578 |
2.15 OR 95% CI: 1.72-2.67 |
Binary
nominal
|
|
|
Glucose
30740-raw |
Glucose (mmol/L) Field 30740, raw |
MGI | DBSLMM | UK Biobank GWAS | 7600988 | 2e-31 | 0.0066 | 309.9452 | 0.227 Beta 95% CI: 0.1372-0.3168 |
Quantitative
nominal
|
|||
|
T2D
29358691-GCST005413 |
Type 2 diabetes T2D |
MGI | C+T (GT) | Large GWAS | 46 | 1.1e-30 | 0.0169 | 0.144 | 0.1442 | 0.56 0.545-0.576 |
2.19 OR 95% CI: 1.76-2.72 |
Binary
nominal
|
|
|
CRP
30710-irnt |
C-reactive protein (IRNT) C-reactive protein (quantile); Field 30710, IRNT |
MGI | PRS-CS | UK Biobank GWAS | 1113831 | 6.2e-30 | 0.022 | 0.5832 | 0.442 Beta 95% CI: 0.2484-0.6356 |
Quantitative
nominal
|
|||
|
Alcohol
20117-2 |
Current alcohol drinker Alcohol drinker status: Current |
MGI | PRS-CS | UK Biobank GWAS | 1113832 | 5.1e-29 | 0.0064 | 0.212 | 0.2119 | 0.547 0.539-0.555 |
1.54 OR 95% CI: 1.23-1.92 |
Binary
nominal
|
|
|
eGFRcr
eGFRcrea-overall-EA |
Estimated glomerular filtration rate based on creatinine eGFRcrea |
MGI | PRS-CS | Large GWAS | 16682 | 8.8e-29 | 0.0042 | 0.0393 | -0.0993 Beta 95% CI: -0.1834--0.0152 |
Quantitative
nominal
reversed effect
|
|||
|
Vit D
30890-raw |
Vitamin D (nmol/L) Field 30890, raw |
MGI | DBSLMM | UK Biobank GWAS | 10313258 | 2.1e-28 | 0.0151 | 79.7213 | 0.19 Beta 95% CI: 0.0267-0.3533 |
Quantitative
nominal
|
|||
|
SBP
93-irnt |
Systolic blood pressure, manual (IRNT) Systolic blood pressure, manual reading; Field 93, IRNT |
MGI | PRS-CS | UK Biobank GWAS | 1113774 | 1.2e-26 | 0.0042 | 142.9779 | 0.162 Beta 95% CI: 0.0767-0.2473 |
Quantitative
nominal
|
|||
|
Smoking
20116-1 |
Previous smoker Smoking status: Previous |
MGI | C+T (GT) | UK Biobank GWAS | 27004 | 1.8e-26 | 0.0059 | 0.239 | 0.2389 | 0.541 0.533-0.549 |
1.39 OR 95% CI: 1.15-1.68 |
Binary
nominal
|
|
|
Vit D
29343764-GCST005367 |
Vitamin D |
MGI | C+T (DS) | Large GWAS | 16 | 2.4e-25 | 0.0144 | 79.8799 | 0.377 Beta 95% CI: 0.2139-0.5401 |
Quantitative
nominal
|
|||
|
Menopause Age
ieu-a-1004 |
Age at menopause |
UKB | PRS-CS | Large GWAS | 894484 | 1.5e-24 | 0.0012 | 178.413 | 0.0794 Beta 95% CI: 0.0267-0.1321 |
Quantitative
nominal
|
|||
|
Vit D
29343764-GCST005367 |
Vitamin D |
MGI | C+T (GT) | Large GWAS | 15 | 2e-24 | 0.0149 | 79.9277 | 0.342 Beta 95% CI: 0.1789-0.5051 |
Quantitative
nominal
|
|||
|
Vit D
29343764-GCST005367 |
Vitamin D |
MGI | PRS-CS | Large GWAS | 1058027 | 3.5e-24 | 0.0142 | 79.94 | 0.194 Beta 95% CI: 0.0305-0.3575 |
Quantitative
nominal
|
|||
|
CRP
prot-a-670 |
C-reactive protein |
UKB | PRS-CS | Large GWAS | 1114754 | 6.2e-24 | 0.0005 | 18.9184 | 0.0663 Beta 95% CI: 0.0347-0.0979 |
Quantitative
nominal
|
|||
|
DBP
94-irnt |
Diastolic blood pressure, manual (IRNT) Diastolic blood pressure, manual reading; Field 94, IRNT |
MGI | PRS-CS | UK Biobank GWAS | 1113774 | 8e-24 | 0.0033 | 46.4368 | 0.0758 Beta 95% CI: -0.0124-0.164 |
Quantitative
nominal
|
|||
|
SBP
93-raw |
Systolic blood pressure, manual reading; Field 93, raw |
MGI | PRS-CS | UK Biobank GWAS | 1113774 | 1.1e-23 | 0.004 | 143.0612 | 0.157 Beta 95% CI: 0.0717-0.2423 |
Quantitative
nominal
|
|||
|
CRP
30710-irnt |
C-reactive protein (IRNT) C-reactive protein (quantile); Field 30710, IRNT |
MGI | C+T (GT) | UK Biobank GWAS | 13371 | 6.7e-23 | 0.0138 | 0.5867 | 0.579 Beta 95% CI: 0.3852-0.7728 |
Quantitative
nominal
|
|||
|
CRP
30710-raw |
C-reactive protein (mg/L) Field 30710, raw |
MGI | PRS-CS | UK Biobank GWAS | 1113831 | 8e-23 | 0.0172 | 0.5868 | 0.641 Beta 95% CI: 0.4475-0.8345 |
Quantitative
nominal
|
|||
|
DBP
94-raw |
Diastolic blood pressure, manual reading; Field 94, raw |
MGI | PRS-CS | UK Biobank GWAS | 1113774 | 3e-22 | 0.0036 | 46.4512 | 0.106 Beta 95% CI: 0.0178-0.1942 |
Quantitative
nominal
|
|||
|
Menopause Age
ieu-a-1004 |
Age at menopause |
UKB | lassosum | Large GWAS | 99745 | 3.4e-22 | 0.0014 | 178.4402 | 0.0829 Beta 95% CI: 0.0302-0.1356 |
Quantitative
nominal
|
|||
|
Alcohol
20117-2 |
Current alcohol drinker Alcohol drinker status: Current |
MGI | lassosum | UK Biobank GWAS | 396976 | 6e-22 | 0.0039 | 0.212 | 0.2122 | 0.539 0.531-0.548 |
1.38 OR 95% CI: 1.11-1.71 |
Binary
nominal
|
|
|
CRP
30710-irnt |
C-reactive protein (IRNT) C-reactive protein (quantile); Field 30710, IRNT |
MGI | DBSLMM | UK Biobank GWAS | 10306310 | 5.7e-21 | 0.0102 | 0.5877 | 0.53 Beta 95% CI: 0.3365-0.7235 |
Quantitative
nominal
|
|||
|
CRP
30710-irnt |
C-reactive protein (IRNT) C-reactive protein (quantile); Field 30710, IRNT |
MGI | lassosum | UK Biobank GWAS | 763400 | 1.5e-20 | 0.0206 | 0.5879 | 0.36 Beta 95% CI: 0.1662-0.5538 |
Quantitative
nominal
|
|||
|
CRP
30710-irnt |
C-reactive protein (IRNT) C-reactive protein (quantile); Field 30710, IRNT |
MGI | C+T (DS) | UK Biobank GWAS | 9373 | 3.3e-20 | 0.0149 | 0.5881 | 0.416 Beta 95% CI: 0.2218-0.6102 |
Quantitative
nominal
|
|||
|
CRP
30710-raw |
C-reactive protein (mg/L) Field 30710, raw |
MGI | lassosum | UK Biobank GWAS | 481279 | 4.2e-19 | 0.0165 | 0.5887 | 0.637 Beta 95% CI: 0.4434-0.8306 |
Quantitative
nominal
|
|||
|
Alcohol
DrinksPerWeek |
Drinks per week DrinksPerWeek |
MGI | PRS-CS | Large GWAS | 1116497 | 1.4e-18 | 0.0038 | 2.7374 | 0.246 Beta 95% CI: 0.1272-0.3648 |
Quantitative
nominal
|
|||
|
Alcohol
DrinksPerWeek |
Drinks per week DrinksPerWeek |
MGI | lassosum | Large GWAS | 524093 | 1.4e-18 | 0.0041 | 2.7374 | 0.165 Beta 95% CI: 0.0462-0.2838 |
Quantitative
nominal
|
|||
|
Alcohol
DrinksPerWeek |
Drinks per week DrinksPerWeek |
MGI | C+T (DS) | Large GWAS | 12650 | 1.2e-17 | 0.0042 | 2.7383 | 0.194 Beta 95% CI: 0.0752-0.3128 |
Quantitative
nominal
|
|||
|
SBP
93-raw |
Systolic blood pressure, manual reading; Field 93, raw |
MGI | lassosum | UK Biobank GWAS | 353555 | 3.6e-16 | 0.0031 | 143.2724 | 0.106 Beta 95% CI: 0.0209-0.1911 |
Quantitative
nominal
|
|||
|
SBP
93-irnt |
Systolic blood pressure, manual (IRNT) Systolic blood pressure, manual reading; Field 93, IRNT |
MGI | lassosum | UK Biobank GWAS | 354112 | 3.2e-15 | 0.0031 | 143.299 | 0.0965 Beta 95% CI: 0.0114-0.1816 |
Quantitative
nominal
|
|||
|
eGFRcr
eGFRcrea-overall-EA |
Estimated glomerular filtration rate based on creatinine eGFRcrea |
UKB | DBSLMM | Large GWAS | 2305 | 7e-15 | 0.0002 | 229.7039 | -0.0598 Beta 95% CI: -0.0874--0.0322 |
Quantitative
nominal
reversed effect
|
|||
|
SBP
93-irnt |
Systolic blood pressure, manual (IRNT) Systolic blood pressure, manual reading; Field 93, IRNT |
MGI | C+T (DS) | UK Biobank GWAS | 11085 | 1.1e-14 | 0.0022 | 143.3142 | 0.105 Beta 95% CI: 0.0199-0.1901 |
Quantitative
nominal
|
|||
|
Menopause Age
ieu-a-1004 |
Age at menopause |
UKB | DBSLMM | Large GWAS | 1379304 | 1.9e-14 | 0.0015 | 178.5303 | 0.116 Beta 95% CI: 0.0633-0.1687 |
Quantitative
nominal
|
|||
|
Alcohol
20117-2 |
Current alcohol drinker Alcohol drinker status: Current |
MGI | C+T (DS) | UK Biobank GWAS | 10123 | 2.1e-14 | 0.0019 | 0.213 | 0.2125 | 0.533 0.525-0.541 |
1.08 OR 95% CI: 0.88-1.32 |
Binary
nominal
|
|
|
Smoking
20116-2 |
Current smoker Smoking status: Current |
MGI | PRS-CS | UK Biobank GWAS | 1113832 | 5.1e-14 | 0.001 | 0.198 | 0.1978 | 0.53 0.522-0.538 |
1.01 OR 95% CI: 0.82-1.24 |
Binary
nominal
|
|
|
CRP
30710-raw |
C-reactive protein (mg/L) Field 30710, raw |
MGI | C+T (GT) | UK Biobank GWAS | 837 | 5e-13 | 0.0133 | 0.5918 | 0.477 Beta 95% CI: 0.2834-0.6706 |
Quantitative
nominal
|
|||
|
Vit D
29343764-GCST005367 |
Vitamin D |
UKB | DBSLMM | Large GWAS | 805427 | 6.4e-13 | 0.0004 | 433.4174 | -0.0877 Beta 95% CI: -0.1198--0.0556 |
Quantitative
nominal
reversed effect
|
|||
|
DBP
94-irnt |
Diastolic blood pressure, manual (IRNT) Diastolic blood pressure, manual reading; Field 94, IRNT |
MGI | lassosum | UK Biobank GWAS | 353663 | 8e-13 | 0.0032 | 46.5372 | 0.157 Beta 95% CI: 0.0688-0.2452 |
Quantitative
nominal
|
|||
|
SBP
93-raw |
Systolic blood pressure, manual reading; Field 93, raw |
MGI | C+T (DS) | UK Biobank GWAS | 13447 | 1.5e-12 | 0.0024 | 143.374 | 0.0835 Beta 95% CI: -0.0016-0.1686 |
Quantitative
nominal
|
|||
|
DBP
94-raw |
Diastolic blood pressure, manual reading; Field 94, raw |
MGI | lassosum | UK Biobank GWAS | 353446 | 2.6e-12 | 0.0031 | 46.5419 | 0.159 Beta 95% CI: 0.0708-0.2472 |
Quantitative
nominal
|
|||
|
CRP
30710-raw |
C-reactive protein (mg/L) Field 30710, raw |
MGI | C+T (DS) | UK Biobank GWAS | 630 | 3e-12 | 0.0129 | 0.5922 | 0.548 Beta 95% CI: 0.3544-0.7416 |
Quantitative
nominal
|
|||
|
Smoking
20116-2 |
Current smoker Smoking status: Current |
MGI | lassosum | UK Biobank GWAS | 515021 | 7.7e-11 | 0.0011 | 0.198 | 0.198 | 0.527 0.518-0.535 |
1.02 OR 95% CI: 0.83-1.26 |
Binary
nominal
|
|
|
Smoking
20116-2 |
Current smoker Smoking status: Current |
MGI | DBSLMM | UK Biobank GWAS | 6575783 | 1.7e-10 | 0.0005 | 0.198 | 0.198 | 0.524 0.517-0.532 |
1.24 OR 95% CI: 1.02-1.52 |
Binary
nominal
|
|
|
SBP
93-irnt |
Systolic blood pressure, manual (IRNT) Systolic blood pressure, manual reading; Field 93, IRNT |
MGI | C+T (GT) | UK Biobank GWAS | 22519 | 3.1e-10 | 0.0021 | 143.4389 | 0.076 Beta 95% CI: -0.0093-0.1613 |
Quantitative
nominal
|
|||
|
CRP
30710-raw |
C-reactive protein (mg/L) Field 30710, raw |
MGI | DBSLMM | UK Biobank GWAS | 10306271 | 3.4e-10 | 0.008 | 0.5933 | 0.276 Beta 95% CI: 0.0822-0.4698 |
Quantitative
nominal
|
|||
|
Sleep Apnea
G6-SLEEPAPNO |
Sleep apnea Sleep apnoea |
MGI | PRS-CS | UK Biobank GWAS | 1111194 | 5.8e-10 | 0.0026 | 0.182 | 0.1822 | 0.527 0.517-0.536 |
1.23 OR 95% CI: 0.996-1.52 |
Binary
nominal
|
|
|
Urine Creatinine
30510-raw |
Urine creatinine (enzymatic) Creatinine (enzymatic) in urine; Field 30510, raw |
MGI | PRS-CS | UK Biobank GWAS | 1113832 | 6.9e-10 | 0.0004 | 0.0394 | 0.0186 Beta 95% CI: -0.0655-0.1027 |
Quantitative
nominal
|
|||
|
Low BMI
STILTS-UKHLS |
Thinness / low BMI Body mass index (<=18, thin low BMI; 19~30, control, normal BMI) |
UKB | PRS-CS | Large GWAS | 1117469 | 8.1e-10 | 0.0016 | 0.0087 | 0.0087 | 0.537 0.523-0.55 |
1.47 OR 95% CI: 1.11-1.93 |
Binary
nominal
|
|
|
Urine Creatinine
30510-irnt |
Urine creatinine (IRNT) Creatinine (enzymatic) in urine; Field 30510, IRNT |
MGI | PRS-CS | UK Biobank GWAS | 1113832 | 9.9e-10 | 0.0005 | 0.0394 | 0.0997 Beta 95% CI: 0.0156-0.1838 |
Quantitative
nominal
|
|||
|
DBP
94-raw |
Diastolic blood pressure, manual reading; Field 94, raw |
MGI | C+T (GT) | UK Biobank GWAS | 22461 | 1.5e-9 | 0.0023 | 46.567 | 0.157 Beta 95% CI: 0.0688-0.2452 |
Quantitative
nominal
|
|||
|
DBP
94-irnt |
Diastolic blood pressure, manual (IRNT) Diastolic blood pressure, manual reading; Field 94, IRNT |
MGI | C+T (GT) | UK Biobank GWAS | 27506 | 3.8e-9 | 0.0021 | 46.5706 | 0.13 Beta 95% CI: 0.0418-0.2182 |
Quantitative
nominal
|
|||
|
SBP
93-raw |
Systolic blood pressure, manual reading; Field 93, raw |
MGI | C+T (GT) | UK Biobank GWAS | 27471 | 6.4e-9 | 0.0019 | 143.4756 | 0.0517 Beta 95% CI: -0.0336-0.137 |
Quantitative
nominal
|
|||
|
DBP
94-raw |
Diastolic blood pressure, manual reading; Field 94, raw |
MGI | C+T (DS) | UK Biobank GWAS | 10968 | 8.9e-9 | 0.0023 | 46.574 | 0.0875 Beta 95% CI: -0.0007-0.1757 |
Quantitative
nominal
|
|||
|
DBP
94-irnt |
Diastolic blood pressure, manual (IRNT) Diastolic blood pressure, manual reading; Field 94, IRNT |
MGI | C+T (DS) | UK Biobank GWAS | 13289 | 1.6e-8 | 0.0022 | 46.5763 | 0.0184 Beta 95% CI: -0.0698-0.1066 |
Quantitative
nominal
|
|||
|
Alcohol
DrinksPerWeek |
Drinks per week DrinksPerWeek |
MGI | C+T (GT) | Large GWAS | 27085 | 2.7e-8 | 0.0031 | 2.7469 | 0.118 Beta 95% CI: -0.001-0.237 |
Quantitative
nominal
|
|||
|
Alcohol
20117-2 |
Current alcohol drinker Alcohol drinker status: Current |
MGI | C+T (GT) | UK Biobank GWAS | 20050 | 8.4e-8 | 0.0029 | 0.213 | 0.2128 | 0.521 0.513-0.529 |
1.04 OR 95% CI: 0.848-1.28 |
Binary
nominal
|
|
|
Urine Creatinine
30510-irnt |
Urine creatinine (IRNT) Creatinine (enzymatic) in urine; Field 30510, IRNT |
MGI | DBSLMM | UK Biobank GWAS | 7062258 | 1.7e-7 | 0.0003 | 0.0394 | 0.0647 Beta 95% CI: -0.0196-0.149 |
Quantitative
nominal
|
|||
|
Urine Creatinine
30510-raw |
Urine creatinine (enzymatic) Creatinine (enzymatic) in urine; Field 30510, raw |
MGI | C+T (GT) | UK Biobank GWAS | 19006 | 5.3e-7 | 0.0003 | 0.0394 | 0.0563 Beta 95% CI: -0.0278-0.1404 |
Quantitative
nominal
|
|||
|
Low BMI
STILTS-UKHLS |
Thinness / low BMI Body mass index (<=18, thin low BMI; 19~30, control, normal BMI) |
UKB | lassosum | Large GWAS | 281336 | 5.6e-7 | 0.0028 | 0.0087 | 0.0087 | 0.53 0.517-0.543 |
1.72 OR 95% CI: 1.34-2.22 |
Binary
nominal
|
|
|
CRP
prot-a-670 |
C-reactive protein |
MGI | C+T (DS) | Large GWAS | 5 | 1.1e-6 | 0.0067 | 0.5951 | 0.288 Beta 95% CI: 0.0942-0.4818 |
Quantitative
nominal
|
|||
|
CRP
prot-a-670 |
C-reactive protein |
MGI | C+T (GT) | Large GWAS | 5 | 1.1e-6 | 0.0067 | 0.5951 | 0.288 Beta 95% CI: 0.0942-0.4818 |
Quantitative
nominal
|
|||
|
SBP
93-irnt |
Systolic blood pressure, manual (IRNT) Systolic blood pressure, manual reading; Field 93, IRNT |
MGI | DBSLMM | UK Biobank GWAS | 6341932 | 1.2e-6 | 0.0006 | 143.5387 | 0.0277 Beta 95% CI: -0.0574-0.1128 |
Quantitative
nominal
|
|||
|
DBP
94-irnt |
Diastolic blood pressure, manual (IRNT) Diastolic blood pressure, manual reading; Field 94, IRNT |
MGI | DBSLMM | UK Biobank GWAS | 7218263 | 1.3e-6 | 0.0004 | 46.5934 | 0.0058 Beta 95% CI: -0.0822-0.0938 |
Quantitative
nominal
|
|||
|
Vit D
30890-irnt |
Vitamin D (IRNT) Vitamin D (quantile); Field 30890, IRNT |
MGI | DBSLMM | UK Biobank GWAS | 10313259 | 1.4e-6 | 0.0047 | 80.8573 | 0.157 Beta 95% CI: -0.0063-0.3203 |
Quantitative
nominal
|
|||
|
eGFRcys
CKDGen-1000Genomes-DiscoveryMeta-eGFRcys |
Estimated glomerular filtration rate based on cystatin C eGFRcys |
UKB | DBSLMM | Large GWAS | 11672 | 3e-6 | 0 | 0.0261 | -0.0212 Beta 95% CI: -0.0506-0.0082 |
Quantitative
nominal
reversed effect
|
|||
|
Alcohol
20403 |
Alcohol intake on a typical drinking day Amount of alcohol drunk on a typical drinking day |
MGI | C+T (DS) | UK Biobank GWAS | 19 | 3.7e-6 | 0.0021 | 2.7489 | 0.0133 Beta 95% CI: -0.1055-0.1321 |
Quantitative
nominal
|
|||
|
Urine Creatinine
30510-raw |
Urine creatinine (enzymatic) Creatinine (enzymatic) in urine; Field 30510, raw |
MGI | lassosum | UK Biobank GWAS | 530378 | 4.8e-6 | 0.0009 | 0.0394 | 0.126 Beta 95% CI: 0.0419-0.2101 |
Quantitative
nominal
|
|||
|
Insomnia
1200 |
Sleeplessness / insomnia |
MGI | PRS-CS | UK Biobank GWAS | 1065129 | 5e-6 | 0.0009 | 0.126 | 0.1259 | 0.524 0.513-0.536 |
1.56 OR 95% CI: 1.2-2.02 |
Binary
nominal
|
|
|
Urine Creatinine
30510-raw |
Urine creatinine (enzymatic) Creatinine (enzymatic) in urine; Field 30510, raw |
MGI | C+T (DS) | UK Biobank GWAS | 10760 | 5.4e-6 | 0.0004 | 0.0394 | 0.0926 Beta 95% CI: 0.0085-0.1767 |
Quantitative
nominal
|
|||
|
Urine Creatinine
30510-raw |
Urine creatinine (enzymatic) Creatinine (enzymatic) in urine; Field 30510, raw |
MGI | DBSLMM | UK Biobank GWAS | 7021804 | 5.6e-6 | 0.0003 | 0.0394 | 0.0862 Beta 95% CI: 0.0019-0.1705 |
Quantitative
nominal
|
|||
|
HTN
I10 |
Essential hypertension (ICD-10 I10) ICD-10 I10 Essential (primary) hypertension |
MGI | C+T (DS) | UK Biobank GWAS | 58725 | 6.4e-6 | 0.0005 | 0.192 | 0.1917 | 0.522 0.513-0.53 |
1.17 OR 95% CI: 0.949-1.44 |
Binary
nominal
|
|
|
CRP
prot-a-670 |
C-reactive protein |
MGI | lassosum | Large GWAS | 316203 | 6.8e-6 | 0.0067 | 0.5955 | 0.21 Beta 95% CI: 0.0164-0.4036 |
Quantitative
nominal
|
|||
|
HTN
I10 |
Essential hypertension (ICD-10 I10) ICD-10 I10 Essential (primary) hypertension |
MGI | PRS-CS | UK Biobank GWAS | 1096197 | 7.7e-6 | 0.0005 | 0.192 | 0.1917 | 0.519 0.51-0.527 |
1.14 OR 95% CI: 0.923-1.41 |
Binary
nominal
|
|
|
Sleep Apnea
G6-SLEEPAPNO |
Sleep apnea Sleep apnoea |
MGI | C+T (DS) | UK Biobank GWAS | 40992 | 1.2e-5 | 0.0011 | 0.182 | 0.1824 | 0.519 0.51-0.528 |
1.18 OR 95% CI: 0.956-1.46 |
Binary
nominal
|
|
|
Urine Creatinine
30510-irnt |
Urine creatinine (IRNT) Creatinine (enzymatic) in urine; Field 30510, IRNT |
MGI | lassosum | UK Biobank GWAS | 557260 | 1.4e-5 | 0.0009 | 0.0395 | 0.116 Beta 95% CI: 0.0319-0.2001 |
Quantitative
nominal
|
|||
|
Height
GIANT-Yang2012-height |
Height |
UKB | C+T (GT) | Large GWAS | 31700 | 1.9e-5 | 0.0001 | 39.8708 | 0.0264 Beta 95% CI: 0.0052-0.0476 |
Quantitative
nominal
|
|||
|
HTN
I10 |
Essential hypertension (ICD-10 I10) ICD-10 I10 Essential (primary) hypertension |
MGI | C+T (GT) | UK Biobank GWAS | 56978 | 2e-5 | 0.0006 | 0.192 | 0.1918 | 0.521 0.512-0.53 |
1.09 OR 95% CI: 0.885-1.35 |
Binary
nominal
|
|
|
Height
GIANT-Yang2012-height |
Height |
UKB | C+T (DS) | Large GWAS | 31267 | 2.3e-5 | 0.0001 | 39.8709 | 0.027 Beta 95% CI: 0.0058-0.0482 |
Quantitative
nominal
|
|||
|
HTN
I10 |
Essential hypertension (ICD-10 I10) ICD-10 I10 Essential (primary) hypertension |
MGI | lassosum | UK Biobank GWAS | 294142 | 2.4e-5 | 0.0006 | 0.192 | 0.1918 | 0.517 0.509-0.526 |
1.12 OR 95% CI: 0.906-1.37 |
Binary
nominal
|
|
|
Low BMI
STILTS-UKHLS |
Thinness / low BMI Body mass index (<=18, thin low BMI; 19~30, control, normal BMI) |
UKB | C+T (GT) | Large GWAS | 5164 | 2.5e-5 | 0.0013 | 0.0087 | 0.0087 | 0.521 0.508-0.535 |
1.89 OR 95% CI: 1.48-2.42 |
Binary
nominal
|
|
|
SBP
93-raw |
Systolic blood pressure, manual reading; Field 93, raw |
MGI | DBSLMM | UK Biobank GWAS | 6762103 | 2.8e-5 | 0.0002 | 143.5759 | 0.0346 Beta 95% CI: -0.0505-0.1197 |
Quantitative
nominal
|
|||
|
Insomnia
1200 |
Sleeplessness / insomnia |
MGI | C+T (DS) | UK Biobank GWAS | 28289 | 3e-5 | 0.0014 | 0.126 | 0.126 | 0.524 0.512-0.535 |
1.31 OR 95% CI: 0.995-1.73 |
Binary
nominal
|
|
|
Low BMI
STILTS-UKHLS |
Thinness / low BMI Body mass index (<=18, thin low BMI; 19~30, control, normal BMI) |
UKB | C+T (DS) | Large GWAS | 4280 | 3.4e-5 | 0.0011 | 0.0087 | 0.0087 | 0.527 0.513-0.542 |
1.33 OR 95% CI: 1-1.78 |
Binary
nominal
|
|
|
Insomnia
1200 |
Sleeplessness / insomnia |
MGI | C+T (GT) | UK Biobank GWAS | 27462 | 1e-4 | 0.0011 | 0.126 | 0.126 | 0.522 0.511-0.534 |
1.26 OR 95% CI: 0.959-1.66 |
Binary
nominal
|
|
|
Urine Creatinine
30510-irnt |
Urine creatinine (IRNT) Creatinine (enzymatic) in urine; Field 30510, IRNT |
MGI | C+T (DS) | UK Biobank GWAS | 11173 | 1.1e-4 | 0.0006 | 0.0395 | 0.147 Beta 95% CI: 0.0629-0.2311 |
Quantitative
nominal
|
|||
|
HTN
20002-1072 |
Self-reported essential hypertension |
MGI | PRS-CS | UK Biobank GWAS | 1109030 | 1.2e-4 | 0.0021 | 0.192 | 0.1918 | 0.516 0.507-0.524 |
1.54 OR 95% CI: 1.25-1.9 |
Binary
nominal
|
|
|
Smoking
20116-2 |
Current smoker Smoking status: Current |
MGI | C+T (GT) | UK Biobank GWAS | 2146 | 1.3e-4 | 0.0006 | 0.198 | 0.1982 | 0.514 0.506-0.523 |
1.02 OR 95% CI: 0.83-1.25 |
Binary
nominal
|
|
|
Alcohol
DrinksPerWeek |
Drinks per week DrinksPerWeek |
UKB | PRS-CS | Large GWAS | 1117376 | 1.9e-4 | 0.0003 | 2272.0864 | 0.0282 Beta 95% CI: -0.0282-0.0846 |
Quantitative
nominal
|
|||
|
Sleep Apnea
G6-SLEEPAPNO |
Sleep apnea Sleep apnoea |
MGI | C+T (GT) | UK Biobank GWAS | 39223 | 2.4e-4 | 0.0014 | 0.182 | 0.1824 | 0.515 0.506-0.525 |
1.15 OR 95% CI: 0.924-1.42 |
Binary
nominal
|
|
|
Urine Creatinine
30510-irnt |
Urine creatinine (IRNT) Creatinine (enzymatic) in urine; Field 30510, IRNT |
MGI | C+T (GT) | UK Biobank GWAS | 19491 | 2.6e-4 | 0.0004 | 0.0395 | 0.115 Beta 95% CI: 0.0309-0.1991 |
Quantitative
nominal
|
|||
|
Height
GIANT-Yang2012-height |
Height |
MGI | C+T (GT) | Large GWAS | 22443 | 0.001 | 0.0009 | 46.3039 | 0.148 Beta 95% CI: 0.0784-0.2176 |
Quantitative
nominal
|
|||
|
Vit B12
Wood-et-al-2013-1000G |
Vitamin B12 |
MGI | C+T (DS) | Large GWAS | 9 | 0.0011 | 0.001 | 64200.4904 | 0.122 Beta 95% CI: -0.0897-0.3337 |
Quantitative
nominal
|
|||
|
Vit B12
Wood-et-al-2013-1000G |
Vitamin B12 |
MGI | C+T (GT) | Large GWAS | 9 | 0.0011 | 0.001 | 64200.4904 | 0.122 Beta 95% CI: -0.0897-0.3337 |
Quantitative
nominal
|
|||
|
Sleep Apnea
G6-SLEEPAPNO |
Sleep apnea Sleep apnoea |
MGI | lassosum | UK Biobank GWAS | 328671 | 0.0014 | 0.0015 | 0.182 | 0.1824 | 0.514 0.506-0.523 |
1.26 OR 95% CI: 1.02-1.56 |
Binary
nominal
|
|
|
Smoking
20116-2 |
Current smoker Smoking status: Current |
MGI | C+T (DS) | UK Biobank GWAS | 1485 | 0.0015 | 0.0009 | 0.198 | 0.1982 | 0.511 0.503-0.52 |
1.09 OR 95% CI: 0.89-1.33 |
Binary
nominal
|
|
|
eGFRcr
CKDGen-1000Genomes-DiscoveryMeta-eGFRcrea |
Estimated glomerular filtration rate based on creatinine eGFRcrea |
UKB | DBSLMM | Large GWAS | 22376 | 0.0016 | 0.0001 | 232.3223 | -0.0352 Beta 95% CI: -0.0628--0.0076 |
Quantitative
nominal
reversed effect
|
|||
|
DBP
94-raw |
Diastolic blood pressure, manual reading; Field 94, raw |
MGI | DBSLMM | UK Biobank GWAS | 6683891 | 0.0019 | 0.0002 | 46.6213 | -0.0483 Beta 95% CI: -0.1363-0.0397 |
Quantitative
nominal
|
|||
|
Vit B12
Wood-et-al-2013-1000G |
Vitamin B12 |
MGI | lassosum | Large GWAS | 263612 | 0.002 | 0.0028 | 64216.198 | 0.338 Beta 95% CI: 0.1263-0.5497 |
Quantitative
nominal
|
|||
|
Height
GIANT-Yang2012-height |
Height |
MGI | C+T (DS) | Large GWAS | 22154 | 0.0024 | 0.0009 | 46.3071 | 0.161 Beta 95% CI: 0.0916-0.2304 |
Quantitative
nominal
|
|||
|
Alcohol
20403 |
Alcohol intake on a typical drinking day Amount of alcohol drunk on a typical drinking day |
MGI | lassosum | UK Biobank GWAS | 375749 | 0.0045 | 0.0016 | 2.7516 | 0.0045 Beta 95% CI: -0.1142-0.1233 |
Quantitative
nominal
|
|||
|
eGFRcr
CKDGen-1000Genomes-DiscoveryMeta-eGFRcrea |
Estimated glomerular filtration rate based on creatinine eGFRcrea |
MGI | DBSLMM | Large GWAS | 59729 | 0.0047 | 0.0002 | 0.0395 | -0.0379 Beta 95% CI: -0.1222-0.0464 |
Quantitative
nominal
|
|||
|
CRP
28887542-GCST004941 |
C-reactive protein |
UKB | C+T (DS) | Large GWAS | 2 | 0.0053 | 0 | 18.9275 | 0.0084 Beta 95% CI: 0.002-0.0148 |
Quantitative
nominal
|
|||
|
Alcohol
DrinksPerWeek |
Drinks per week DrinksPerWeek |
UKB | lassosum | Large GWAS | 524875 | 0.0055 | 0.0004 | 2272.318 | 0.0309 Beta 95% CI: -0.0255-0.0873 |
Quantitative
nominal
|
|||
|
HTN
finngen-R4-FG |
Essential hypertension ICD-10 I10 Essential (primary) hypertension |
UKB | lassosum | Large GWAS | 6731 | 0.0079 | 0.0001 | 0.143 | 0.1431 | 0.505 0.502-0.509 |
1.05 OR 95% CI: 0.965-1.13 |
Binary
nominal
|
|
|
FPG
MAGIC-FastingGlucose |
Fasting plasma glucose Fast Plasma glucose |
MGI | C+T (GT) | Large GWAS | 273 | 0.0095 | 0.0795 | 98.7964 | 0.584 Beta 95% CI: -0.1392-1.3072 |
Quantitative
nominal
|
|||
|
Alcohol
20117-2 |
Current alcohol drinker Alcohol drinker status: Current |
MGI | DBSLMM | UK Biobank GWAS | 8598752 | 0.011 | 0.001 | 0.213 | 0.213 | 0.52 0.512-0.528 |
0.995 OR 95% CI: 0.809-1.22 |
Binary
nominal
|
|
|
Alcohol
DrinksPerWeek |
Drinks per week DrinksPerWeek |
UKB | C+T (GT) | Large GWAS | 22675 | 0.011 | 0.0004 | 2272.3648 | 0.0132 Beta 95% CI: -0.0432-0.0696 |
Quantitative
nominal
|
|||
|
Alcohol
20403 |
Alcohol intake on a typical drinking day Amount of alcohol drunk on a typical drinking day |
MGI | DBSLMM | UK Biobank GWAS | 5498032 | 0.012 | 0.0006 | 2.752 | 0.163 Beta 95% CI: 0.0442-0.2818 |
Quantitative
nominal
|
|||
|
FPG
MAGIC-FastingGlucose |
Fasting plasma glucose Fast Plasma glucose |
MGI | C+T (DS) | Large GWAS | 264 | 0.015 | 0.0689 | 99.0653 | 0.584 Beta 95% CI: -0.1392-1.3072 |
Quantitative
nominal
|
|||
|
HTN
20002-1072 |
Self-reported essential hypertension |
MGI | lassosum | UK Biobank GWAS | 313080 | 0.017 | 0.0013 | 0.192 | 0.1918 | 0.508 0.498-0.516 |
1.28 OR 95% CI: 1.04-1.58 |
Binary
nominal
|
|
|
HTN
20002-1072 |
Self-reported essential hypertension |
MGI | C+T (DS) | UK Biobank GWAS | 83829 | 0.024 | 0.001 | 0.192 | 0.1918 | 0.507 0.498-0.516 |
1.19 OR 95% CI: 0.963-1.46 |
Binary
nominal
|
|
|
Height
GIANT-Yang2012-height |
Height |
MGI | PRS-CS | Large GWAS | 996356 | 0.025 | 0.0007 | 46.3154 | 0.0195 Beta 95% CI: -0.0436-0.0826 |
Quantitative
nominal
|
|||
|
Alcohol
20403 |
Alcohol intake on a typical drinking day Amount of alcohol drunk on a typical drinking day |
MGI | C+T (GT) | UK Biobank GWAS | 25 | 0.031 | 0.0018 | 2.7523 | -0.0592 Beta 95% CI: -0.178-0.0596 |
Quantitative
nominal
|
|||
|
HTN
20002-1072 |
Self-reported essential hypertension |
MGI | C+T (GT) | UK Biobank GWAS | 81218 | 0.034 | 0.001 | 0.192 | 0.1919 | 0.507 0.498-0.516 |
1.24 OR 95% CI: 1-1.53 |
Binary
nominal
|
|
|
CRP
28887542-GCST004941 |
C-reactive protein |
UKB | C+T (GT) | Large GWAS | 2 | 0.034 | 0 | 18.9278 | 0.002 Beta 95% CI: -0.0116-0.0157 |
Quantitative
nominal
|
|||
|
HTN
finngen-R4-FG |
Essential hypertension ICD-10 I10 Essential (primary) hypertension |
UKB | PRS-CS | Large GWAS | 12097 | 0.04 | 0.0001 | 0.143 | 0.1431 | 0.506 0.502-0.509 |
1.01 OR 95% CI: 0.93-1.09 |
Binary
nominal
|
|
|
Low BMI
STILTS-UKHLS |
Thinness / low BMI Body mass index (<=18, thin low BMI; 19~30, control, normal BMI) |
MGI | C+T (DS) | Large GWAS | 256 | 0.044 | 0.0012 | 0.0178 | 0.0178 | 0.532 0.503-0.561 |
0.591 OR 95% CI: 0.233-1.5 |
Binary
nominal
|
|
|
Alcohol
DrinksPerWeek |
Drinks per week DrinksPerWeek |
UKB | C+T (DS) | Large GWAS | 10706 | 0.045 | 0.0004 | 2272.4561 | 0.0018 Beta 95% CI: -0.0546-0.0582 |
Quantitative
nominal
|
|||
|
Estradiol
30800-raw |
Estradiol (pmol/L) Oestradiol (pmol/L); Field 30800, raw |
MGI | PRS-CS | UK Biobank GWAS | 1113823 | 0.046 | 0.0025 | 2513.8428 | -0.0085 Beta 95% CI: -0.4534-0.4365 |
Quantitative
nominal
|
|||
|
Insomnia
1200 |
Sleeplessness / insomnia |
MGI | DBSLMM | UK Biobank GWAS | 6214923 | 0.07 | 0.0016 | 0.126 | 0.1261 | 0.51 0.499-0.521 |
1.41 OR 95% CI: 1.08-1.84 |
Binary
weak
|
|
|
Height
GIANT-Yang2012-height |
Height |
MGI | DBSLMM | Large GWAS | 1851736 | 0.071 | 0 | 46.3189 | -0.0003 Beta 95% CI: -0.0617-0.061 |
Quantitative
weak
|
|||
|
FPG
MAGIC-FastingGlucose |
Fasting plasma glucose Fast Plasma glucose |
MGI | PRS-CS | Large GWAS | 1007415 | 0.077 | 0.0497 | 100.0806 | 0.0743 Beta 95% CI: -0.6431-0.7917 |
Quantitative
weak
|
|||
|
Low BMI
STILTS-UKHLS |
Thinness / low BMI Body mass index (<=18, thin low BMI; 19~30, control, normal BMI) |
MGI | lassosum | Large GWAS | 224595 | 0.079 | 0.0019 | 0.0178 | 0.0178 | 0.525 0.493-0.556 |
1.1 OR 95% CI: 0.529-2.28 |
Binary
weak
|
|
|
Low BMI
STILTS-UKHLS |
Thinness / low BMI Body mass index (<=18, thin low BMI; 19~30, control, normal BMI) |
UKB | DBSLMM | Large GWAS | 41698 | 0.083 | 0 | 0.0087 | 0.0087 | 0.49 0.476-0.505 |
0.965 OR 95% CI: 0.689-1.35 |
Binary
weak
reversed effect
|
|
|
HTN
finngen-R4-FG |
Essential hypertension ICD-10 I10 Essential (primary) hypertension |
UKB | C+T (GT) | Large GWAS | 24 | 0.085 | 0.0001 | 0.143 | 0.1431 | 0.503 0.5-0.507 |
1.03 OR 95% CI: 0.947-1.11 |
Binary
weak
|
|
|
HTN
finngen-R4-I9 |
Essential hypertension ICD-10 I10 Essential (primary) hypertension |
UKB | lassosum | Large GWAS | 7123 | 0.094 | 0.0001 | 0.143 | 0.1431 | 0.503 0.5-0.507 |
1.06 OR 95% CI: 0.978-1.15 |
Binary
weak
|
|
|
CRP
28887542-GCST004941 |
C-reactive protein |
UKB | lassosum | Large GWAS | 721243 | 0.11 | 0.0001 | 18.928 | 0.0237 Beta 95% CI: -0.0079-0.0553 |
Quantitative
weak
|
|||
|
Smoking
SmokingInitiation |
Smoking initiation SmokingInitiation |
UKB | DBSLMM | Large GWAS | 244 | 0.11 | 0 | 0.235 | 0.2346 | 0.505 0.502-0.507 |
1.01 OR 95% CI: 0.952-1.08 |
Binary
weak
|
|
|
Vit B12
Wood-et-al-2013-1000G |
Vitamin B12 |
MGI | PRS-CS | Large GWAS | 1100788 | 0.11 | 0 | 64321.8295 | 0.0759 Beta 95% CI: -0.1358-0.2876 |
Quantitative
weak
|
|||
|
Sleep Apnea
finngen-R4-G6-SLEEPAPNO |
Sleep apnea Sleep apnoea |
MGI | DBSLMM | Large GWAS | 355 | 0.11 | 0 | 0.183 | 0.1825 | 0.492 0.484-0.501 |
0.982 OR 95% CI: 0.785-1.23 |
Binary
weak
reversed effect
|
|
|
CRP
prot-a-670 |
C-reactive protein |
MGI | DBSLMM | Large GWAS | 1662602 | 0.11 | 0.0005 | 0.5975 | 0.0726 Beta 95% CI: -0.121-0.2662 |
Quantitative
weak
|
|||
|
Vit D
100021-raw |
Vitamin D Field 100021, raw |
MGI | lassosum | UK Biobank GWAS | 310479 | 0.12 | 0.0002 | 81.1012 | -0.0463 Beta 95% CI: -0.2096-0.117 |
Quantitative
weak
|
|||
|
FPG
FGovertime-corrected |
Fasting plasma glucose Fast Plasma glucose |
UKB | DBSLMM | Large GWAS | 1501 | 0.12 | 0 | 1.451 | 0.0093 Beta 95% CI: -0.0991-0.1177 |
Quantitative
weak
|
|||
|
Height
GIANT-Yang2012-height |
Height |
MGI | lassosum | Large GWAS | 66842 | 0.12 | 0.0005 | 46.3205 | -0.0043 Beta 95% CI: -0.0668-0.0582 |
Quantitative
weak
|
|||
|
FPG
MAGIC-FastingGlucose |
Fasting plasma glucose Fast Plasma glucose |
UKB | DBSLMM | Large GWAS | 1501 | 0.12 | 0 | 1.451 | 0.0093 Beta 95% CI: -0.0991-0.1177 |
Quantitative
weak
|
|||
|
Sleep Apnea
finngen-R4-G6-SLEEPAPNO |
Sleep apnea Sleep apnoea |
MGI | C+T (GT) | Large GWAS | 9873 | 0.12 | 0.0002 | 0.183 | 0.1825 | 0.49 0.48-0.499 |
1.02 OR 95% CI: 0.82-1.28 |
Binary
weak
reversed effect
|
|
|
Sleep Apnea
finngen-R4-G6-SLEEPAPNO |
Sleep apnea Sleep apnoea |
UKB | C+T (DS) | Large GWAS | 1209 | 0.12 | 0.0002 | 0.0107 | 0.0107 | 0.489 0.477-0.501 |
0.661 OR 95% CI: 0.459-0.951 |
Binary
weak
reversed effect
|
|
|
HTN
finngen-R4-I9 |
Essential hypertension ICD-10 I10 Essential (primary) hypertension |
UKB | C+T (DS) | Large GWAS | 9 | 0.12 | 0 | 0.143 | 0.1431 | 0.504 0.501-0.507 |
1.02 OR 95% CI: 0.942-1.1 |
Binary
weak
reversed effect
|
|
|
Vit D
100021-irnt |
Vitamin D Field 100021, IRNT |
MGI | C+T (DS) | UK Biobank GWAS | 11 | 0.13 | 0.0003 | 81.1034 | -0.105 Beta 95% CI: -0.2683-0.0583 |
Quantitative
weak
|
|||
|
Sleep Duration
1160 |
Sleep duration |
MGI | DBSLMM | UK Biobank GWAS | 8590163 | 0.13 | 0.0001 | 0.126 | 0.1261 | 0.492 0.481-0.504 |
0.992 OR 95% CI: 0.74-1.33 |
Binary
weak
reversed effect
|
|
|
T2D
METAANALYSIS-DIAGRAM |
Type 2 diabetes T2D |
MGI | DBSLMM | Large GWAS | 995 | 0.13 | 0 | 0.145 | 0.1452 | 0.541 0.523-0.557 |
1.04 OR 95% CI: 0.813-1.34 |
Binary
weak
|
|
|
HTN
finngen-R4-I9 |
Essential hypertension ICD-10 I10 Essential (primary) hypertension |
MGI | C+T (GT) | Large GWAS | 3300 | 0.13 | 0.0002 | 0.192 | 0.1919 | 0.505 0.496-0.514 |
1.2 OR 95% CI: 0.976-1.48 |
Binary
weak
|
|
|
HTN
finngen-R4-I9 |
Essential hypertension ICD-10 I10 Essential (primary) hypertension |
UKB | PRS-CS | Large GWAS | 12097 | 0.13 | 0 | 0.143 | 0.1431 | 0.505 0.502-0.509 |
0.984 OR 95% CI: 0.905-1.07 |
Binary
weak
|
|
|
Vit D
100021-irnt |
Vitamin D Field 100021, IRNT |
MGI | C+T (GT) | UK Biobank GWAS | 19 | 0.14 | 0.0002 | 81.104 | 0.0592 Beta 95% CI: -0.1041-0.2225 |
Quantitative
weak
|
|||
|
Vit D
100021-raw |
Vitamin D Field 100021, raw |
MGI | C+T (DS) | UK Biobank GWAS | 5 | 0.14 | 0.0004 | 81.1052 | 0.109 Beta 95% CI: -0.0543-0.2723 |
Quantitative
weak
|
|||
|
Alcohol
20403 |
Alcohol intake on a typical drinking day Amount of alcohol drunk on a typical drinking day |
MGI | PRS-CS | UK Biobank GWAS | 1113829 | 0.14 | 0.0007 | 2.7529 | 0.135 Beta 95% CI: 0.0162-0.2538 |
Quantitative
weak
|
|||
|
HTN
finngen-R4-I9 |
Essential hypertension ICD-10 I10 Essential (primary) hypertension |
MGI | C+T (DS) | Large GWAS | 1894 | 0.14 | 0.0001 | 0.192 | 0.1919 | 0.507 0.498-0.515 |
1.01 OR 95% CI: 0.816-1.24 |
Binary
weak
|
|
|
Estradiol
30800-irnt |
Estradiol (IRNT) Oestradiol (quantile); Field 30800, IRNT |
MGI | C+T (DS) | UK Biobank GWAS | 4661 | 0.16 | 0.0014 | 2519.4048 | 0.0146 Beta 95% CI: -0.4303-0.4595 |
Quantitative
weak
reversed effect
|
|||
|
Low BMI
STILTS-UKHLS |
Thinness / low BMI Body mass index (<=18, thin low BMI; 19~30, control, normal BMI) |
MGI | C+T (GT) | Large GWAS | 351 | 0.16 | 0.0008 | 0.0178 | 0.0178 | 0.516 0.49-0.541 |
1.52 OR 95% CI: 0.842-2.76 |
Binary
weak
|
|
|
HTN
finngen-R4-FG |
Essential hypertension ICD-10 I10 Essential (primary) hypertension |
UKB | C+T (DS) | Large GWAS | 24 | 0.16 | 0 | 0.143 | 0.1431 | 0.506 0.503-0.509 |
1.02 OR 95% CI: 0.945-1.11 |
Binary
weak
reversed effect
|
|
|
FPG
MAGIC-FastingGlucose |
Fasting plasma glucose Fast Plasma glucose |
MGI | lassosum | Large GWAS | 71791 | 0.17 | 0.0369 | 100.5399 | 0.147 Beta 95% CI: -0.5743-0.8683 |
Quantitative
weak
|
|||
|
Estradiol
30800-irnt |
Estradiol (IRNT) Oestradiol (quantile); Field 30800, IRNT |
MGI | DBSLMM | UK Biobank GWAS | 10287664 | 0.2 | 0.0001 | 2520.1233 | 0.181 Beta 95% CI: -0.262-0.624 |
Quantitative
weak
|
|||
|
Vit B12
Wood-et-al-2013-1000G |
Vitamin B12 |
UKB | lassosum | Large GWAS | 291530 | 0.2 | 0.0001 | 19.5817 | 0.0003 Beta 95% CI: -0.0467-0.0473 |
Quantitative
weak
|
|||
|
HTN
finngen-R4-I9 |
Essential hypertension ICD-10 I10 Essential (primary) hypertension |
MGI | DBSLMM | Large GWAS | 361 | 0.2 | 0.0001 | 0.192 | 0.1919 | 0.502 0.493-0.511 |
1.21 OR 95% CI: 0.986-1.49 |
Binary
weak
|
|
|
Insomnia
1200 |
Sleeplessness / insomnia |
MGI | lassosum | UK Biobank GWAS | 464576 | 0.22 | 0.001 | 0.126 | 0.1261 | 0.507 0.496-0.518 |
1.11 OR 95% CI: 0.832-1.48 |
Binary
weak
|
|
|
Sleep Duration
1160 |
Sleep duration |
MGI | C+T (GT) | UK Biobank GWAS | 148 | 0.24 | 0.0004 | 0.126 | 0.1261 | 0.493 0.481-0.505 |
1.13 OR 95% CI: 0.857-1.5 |
Binary
weak
reversed effect
|
|
|
Estradiol
30800-irnt |
Estradiol (IRNT) Oestradiol (quantile); Field 30800, IRNT |
MGI | C+T (GT) | UK Biobank GWAS | 9583 | 0.24 | 0.0026 | 2520.8787 | 0.114 Beta 95% CI: -0.329-0.557 |
Quantitative
weak
|
|||
|
Vit D
100021-irnt |
Vitamin D Field 100021, IRNT |
MGI | DBSLMM | UK Biobank GWAS | 10318270 | 0.25 | 0 | 81.1143 | 0.0889 Beta 95% CI: -0.0744-0.2522 |
Quantitative
weak
|
|||
|
Vit D
100021-raw |
Vitamin D Field 100021, raw |
MGI | PRS-CS | UK Biobank GWAS | 1113819 | 0.25 | 0 | 81.1149 | -0.0485 Beta 95% CI: -0.2118-0.1148 |
Quantitative
weak
|
|||
|
Estradiol
30800-irnt |
Estradiol (IRNT) Oestradiol (quantile); Field 30800, IRNT |
MGI | lassosum | UK Biobank GWAS | 326223 | 0.25 | 0.0037 | 2521.032 | 0.489 Beta 95% CI: 0.0441-0.9339 |
Quantitative
weak
|
|||
|
HTN
finngen-R4-FG |
Essential hypertension ICD-10 I10 Essential (primary) hypertension |
MGI | lassosum | Large GWAS | 4943 | 0.25 | 0.0001 | 0.192 | 0.1919 | 0.51 0.5-0.519 |
0.87 OR 95% CI: 0.708-1.07 |
Binary
weak
reversed effect
|
|
|
Vit B12
100013-irnt |
Vitamin B12 Field 100013, IRNT |
MGI | C+T (GT) | UK Biobank GWAS | 88908 | 0.26 | 0.001 | 64340.0103 | 0.0983 Beta 95% CI: -0.1134-0.31 |
Quantitative
weak
|
|||
|
CRP
28887542-GCST004941 |
C-reactive protein |
UKB | DBSLMM | Large GWAS | 746 | 0.26 | 0 | 18.9281 | 0.008 Beta 95% CI: -0.0235-0.0396 |
Quantitative
weak
reversed effect
|
|||
|
Estradiol
30800-irnt |
Estradiol (IRNT) Oestradiol (quantile); Field 30800, IRNT |
MGI | PRS-CS | UK Biobank GWAS | 1113823 | 0.27 | 0.0015 | 2521.3823 | 0.0178 Beta 95% CI: -0.4271-0.4627 |
Quantitative
weak
|
|||
|
Estradiol
30800-raw |
Estradiol (pmol/L) Oestradiol (pmol/L); Field 30800, raw |
MGI | lassosum | UK Biobank GWAS | 324623 | 0.27 | 0.0022 | 2521.4368 | 0.109 Beta 95% CI: 0.0165-0.2015 |
Quantitative
weak
|
|||
|
eGFRcr
eGFRcrea-overall-EA |
Estimated glomerular filtration rate based on creatinine eGFRcrea |
MGI | DBSLMM | Large GWAS | 3145 | 0.28 | 0.0001 | 0.0395 | 0.0603 Beta 95% CI: -0.0238-0.1444 |
Quantitative
weak
reversed effect
|
|||
|
Sleep Apnea
finngen-R4-G6-SLEEPAPNO |
Sleep apnea Sleep apnoea |
MGI | lassosum | Large GWAS | 4360 | 0.28 | 0.0001 | 0.183 | 0.1825 | 0.49 0.482-0.499 |
1.07 OR 95% CI: 0.86-1.33 |
Binary
weak
reversed effect
|
|
|
Vit B12
Wood-et-al-2013-1000G |
Vitamin B12 |
MGI | DBSLMM | Large GWAS | 9805 | 0.29 | 0.0001 | 64342.7982 | -0.0372 Beta 95% CI: -0.2489-0.1745 |
Quantitative
weak
reversed effect
|
|||
|
Vit D
100021-irnt |
Vitamin D Field 100021, IRNT |
MGI | PRS-CS | UK Biobank GWAS | 1113819 | 0.3 | 0 | 81.1173 | -0.0891 Beta 95% CI: -0.2522-0.074 |
Quantitative
weak
|
|||
|
Sleep Duration
1160 |
Sleep duration |
MGI | C+T (DS) | UK Biobank GWAS | 147 | 0.3 | 0.0003 | 0.126 | 0.1261 | 0.494 0.483-0.505 |
1.16 OR 95% CI: 0.878-1.53 |
Binary
weak
reversed effect
|
|
|
HTN
finngen-R4-FG |
Essential hypertension ICD-10 I10 Essential (primary) hypertension |
MGI | C+T (DS) | Large GWAS | 2860 | 0.3 | 0.0002 | 0.192 | 0.1919 | 0.506 0.497-0.515 |
0.988 OR 95% CI: 0.803-1.21 |
Binary
weak
|
|
|
HTN
finngen-R4-FG |
Essential hypertension ICD-10 I10 Essential (primary) hypertension |
MGI | DBSLMM | Large GWAS | 359 | 0.31 | 0.0001 | 0.192 | 0.1919 | 0.498 0.489-0.507 |
1.16 OR 95% CI: 0.942-1.43 |
Binary
weak
|
|
|
HTN
finngen-R4-I9 |
Essential hypertension ICD-10 I10 Essential (primary) hypertension |
UKB | C+T (GT) | Large GWAS | 9 | 0.31 | 0.0001 | 0.143 | 0.1431 | 0.502 0.498-0.505 |
1.03 OR 95% CI: 0.945-1.11 |
Binary
weak
|
|
|
eGFRcys
CKDGen-1000Genomes-DiscoveryMeta-eGFRcys |
Estimated glomerular filtration rate based on cystatin C eGFRcys |
MGI | lassosum | Large GWAS | 162595 | 0.32 | 0.0397 | 0.2124 | 0.722 Beta 95% CI: -0.3501-1.7941 |
Quantitative
weak
reversed effect
|
|||
|
PUFA
MAGNETIC-otPUFA |
Polyunsaturated fatty acids |
UKB | C+T (DS) | Large GWAS | 13 | 0.32 | 0 | 53.3874 | -0.0201 Beta 95% CI: -0.0669-0.0267 |
Quantitative
weak
reversed effect
|
|||
|
CRP
28887542-GCST004941 |
C-reactive protein |
MGI | C+T (DS) | Large GWAS | 414578 | 0.33 | 0.0007 | 0.5977 | 0.0979 Beta 95% CI: -0.0957-0.2915 |
Quantitative
weak
reversed effect
|
|||
|
Low BMI
STILTS-UKHLS |
Thinness / low BMI Body mass index (<=18, thin low BMI; 19~30, control, normal BMI) |
MGI | PRS-CS | Large GWAS | 1116425 | 0.33 | 0.0001 | 0.0178 | 0.0178 | 0.514 0.49-0.542 |
1.73 OR 95% CI: 0.826-3.62 |
Binary
weak
|
|
|
Sleep Apnea
finngen-R4-G6-SLEEPAPNO |
Sleep apnea Sleep apnoea |
UKB | DBSLMM | Large GWAS | 46 | 0.33 | 0 | 0.0107 | 0.0107 | 0.485 0.475-0.495 |
1.12 OR 95% CI: 0.85-1.49 |
Binary
weak
|
|
|
PUFA
MAGNETIC-otPUFA |
Polyunsaturated fatty acids |
UKB | lassosum | Large GWAS | 378933 | 0.34 | 0 | 53.3874 | -0.0479 Beta 95% CI: -0.0947--0.0011 |
Quantitative
weak
reversed effect
|
|||
|
Sleep Apnea
finngen-R4-G6-SLEEPAPNO |
Sleep apnea Sleep apnoea |
MGI | PRS-CS | Large GWAS | 12076 | 0.34 | 0.0001 | 0.183 | 0.1825 | 0.505 0.497-0.514 |
0.893 OR 95% CI: 0.711-1.12 |
Binary
weak
|
|
|
Vit B12
100013-raw |
Vitamin B12 Field 100013, raw |
MGI | C+T (GT) | UK Biobank GWAS | 190297 | 0.35 | 0.001 | 64346.1365 | 0.0235 Beta 95% CI: -0.1882-0.2352 |
Quantitative
weak
reversed effect
|
|||
|
T2D
29358691-GCST005413 |
Type 2 diabetes T2D |
UKB | DBSLMM | Large GWAS | 222 | 0.35 | 0 | 0.0452 | 0.0452 | 0.501 0.495-0.507 |
1.03 OR 95% CI: 0.892-1.19 |
Binary
weak
|
|
|
eGFRcys
eGFRcys-overall-EA |
Estimated glomerular filtration rate based on cystatin C eGFRcys |
MGI | PRS-CS | Large GWAS | 16681 | 0.35 | 0.0001 | 0.2127 | 0.646 Beta 95% CI: -0.4614-1.7534 |
Quantitative
weak
|
|||
|
eGFRcys
eGFRcys-overall-IV-2GC |
Estimated glomerular filtration rate based on cystatin C eGFRcys |
MGI | C+T (DS) | Large GWAS | 203 | 0.35 | 0.1231 | 0.2127 | 0.126 Beta 95% CI: -0.95-1.202 |
Quantitative
weak
|
|||
|
eGFRcys
eGFRcys-overall-IV-2GC |
Estimated glomerular filtration rate based on cystatin C eGFRcys |
MGI | C+T (GT) | Large GWAS | 204 | 0.35 | 0.1207 | 0.2127 | 0.126 Beta 95% CI: -0.95-1.202 |
Quantitative
weak
|
|||
|
FPG
FGovertime-corrected |
Fasting plasma glucose Fast Plasma glucose |
MGI | PRS-CS | Large GWAS | 392 | 0.36 | 0.0017 | 100.9096 | -0.541 Beta 95% CI: -1.2584-0.1764 |
Quantitative
weak
reversed effect
|
|||
|
FPG
FGovertime-corrected |
Fasting plasma glucose Fast Plasma glucose |
MGI | C+T (DS) | Large GWAS | 13 | 0.37 | 0.006 | 100.9252 | 0.453 Beta 95% CI: -0.2604-1.1664 |
Quantitative
weak
reversed effect
|
|||
|
Sleep Duration
1160 |
Sleep duration |
MGI | lassosum | UK Biobank GWAS | 578551 | 0.38 | 0.0002 | 0.126 | 0.1261 | 0.498 0.486-0.51 |
1.09 OR 95% CI: 0.824-1.45 |
Binary
weak
reversed effect
|
|
|
CRP
28887542-GCST004941 |
C-reactive protein |
MGI | PRS-CS | Large GWAS | 1118117 | 0.39 | 0 | 0.5977 | -0.0677 Beta 95% CI: -0.2615-0.1261 |
Quantitative
weak
reversed effect
|
|||
|
Vit D
100021-raw |
Vitamin D Field 100021, raw |
MGI | C+T (GT) | UK Biobank GWAS | 15 | 0.4 | 0.0007 | 81.1219 | 0.0645 Beta 95% CI: -0.0988-0.2278 |
Quantitative
weak
reversed effect
|
|||
|
Sleep Apnea
G6-SLEEPAPNO |
Sleep apnea Sleep apnoea |
MGI | DBSLMM | UK Biobank GWAS | 7601206 | 0.4 | 0.0003 | 0.183 | 0.1825 | 0.496 0.487-0.504 |
1.28 OR 95% CI: 1.04-1.59 |
Binary
weak
|
|
|
eGFRcys
eGFRcys-overall-EA |
Estimated glomerular filtration rate based on cystatin C eGFRcys |
MGI | C+T (DS) | Large GWAS | 42 | 0.4 | 0.0427 | 0.213 | -0.886 Beta 95% CI: -1.9797-0.2077 |
Quantitative
weak
|
|||
|
HTN
finngen-R4-FG |
Essential hypertension ICD-10 I10 Essential (primary) hypertension |
MGI | C+T (GT) | Large GWAS | 5212 | 0.4 | 0.0002 | 0.192 | 0.1919 | 0.502 0.492-0.511 |
0.932 OR 95% CI: 0.757-1.15 |
Binary
weak
reversed effect
|
|
|
PUFA
MAGNETIC-otPUFA |
Polyunsaturated fatty acids |
UKB | DBSLMM | Large GWAS | 272 | 0.41 | 0 | 53.3875 | -0.0278 Beta 95% CI: -0.0746-0.019 |
Quantitative
weak
reversed effect
|
|||
|
T2D
METAANALYSIS-DIAGRAM |
Type 2 diabetes T2D |
UKB | DBSLMM | Large GWAS | 264 | 0.41 | 0 | 0.0452 | 0.0452 | 0.547 0.541-0.552 |
1.1 OR 95% CI: 0.958-1.27 |
Binary
weak
|
|
|
HTN
finngen-R4-FG |
Essential hypertension ICD-10 I10 Essential (primary) hypertension |
MGI | PRS-CS | Large GWAS | 12076 | 0.41 | 0 | 0.192 | 0.1919 | 0.5 0.49-0.508 |
0.893 OR 95% CI: 0.726-1.1 |
Binary
weak
reversed effect
|
|
|
Vit B12
Wood-et-al-2013-1000G |
Vitamin B12 |
UKB | C+T (DS) | Large GWAS | 2232 | 0.42 | 0.0001 | 19.582 | -0.0238 Beta 95% CI: -0.0708-0.0232 |
Quantitative
weak
reversed effect
|
|||
|
Vit B12
Wood-et-al-2013-1000G |
Vitamin B12 |
UKB | C+T (GT) | Large GWAS | 2232 | 0.42 | 0.0001 | 19.582 | -0.0238 Beta 95% CI: -0.0708-0.0232 |
Quantitative
weak
reversed effect
|
|||
|
CRP
28887542-GCST004941 |
C-reactive protein |
MGI | C+T (GT) | Large GWAS | 407315 | 0.43 | 0.0008 | 0.5978 | 0.126 Beta 95% CI: -0.0676-0.3196 |
Quantitative
weak
reversed effect
|
|||
|
Alcohol
DrinksPerWeek |
Drinks per week DrinksPerWeek |
UKB | DBSLMM | Large GWAS | 137 | 0.43 | 0 | 2272.5833 | -0.0532 Beta 95% CI: -0.1096-0.0032 |
Quantitative
weak
reversed effect
|
|||
|
eGFRcys
eGFRcys-overall-IV-2GC |
Estimated glomerular filtration rate based on cystatin C eGFRcys |
MGI | PRS-CS | Large GWAS | 933013 | 0.43 | 0.0747 | 0.2133 | 0.61 Beta 95% CI: -0.468-1.688 |
Quantitative
weak
reversed effect
|
|||
|
Estradiol
30800-raw |
Estradiol (pmol/L) Oestradiol (pmol/L); Field 30800, raw |
MGI | DBSLMM | UK Biobank GWAS | 10287670 | 0.45 | 0.0006 | 2523.1148 | -0.0837 Beta 95% CI: -0.5286-0.3612 |
Quantitative
weak
|
|||
|
CRP
prot-a-670 |
C-reactive protein |
MGI | PRS-CS | Large GWAS | 1113794 | 0.45 | 0.0007 | 0.5978 | -0.0434 Beta 95% CI: -0.237-0.1502 |
Quantitative
weak
|
|||
|
eGFRcys
CKDGen-1000Genomes-DiscoveryMeta-eGFRcys |
Estimated glomerular filtration rate based on cystatin C eGFRcys |
MGI | DBSLMM | Large GWAS | 88980 | 0.48 | 0.0185 | 0.2135 | -0.463 Beta 95% CI: -1.541-0.615 |
Quantitative
weak
|
|||
|
HTN
finngen-R4-I9 |
Essential hypertension ICD-10 I10 Essential (primary) hypertension |
MGI | lassosum | Large GWAS | 5226 | 0.48 | 0.0001 | 0.192 | 0.1919 | 0.512 0.503-0.521 |
1.04 OR 95% CI: 0.845-1.28 |
Binary
weak
reversed effect
|
|
|
Vit D
100021-irnt |
Vitamin D Field 100021, IRNT |
MGI | lassosum | UK Biobank GWAS | 312224 | 0.5 | 0.0005 | 81.1247 | -0.0458 Beta 95% CI: -0.2091-0.1175 |
Quantitative
weak
|
|||
|
Low BMI
STILTS-UKHLS |
Thinness / low BMI Body mass index (<=18, thin low BMI; 19~30, control, normal BMI) |
MGI | DBSLMM | Large GWAS | 344981 | 0.5 | 0.0001 | 0.0178 | 0.0178 | 0.462 0.453-0.471 |
0.561 OR 95% CI: 0.221-1.42 |
Binary
weak
reversed effect
|
|
|
eGFRcys
eGFRcys-overall-EA |
Estimated glomerular filtration rate based on cystatin C eGFRcys |
MGI | DBSLMM | Large GWAS | 7372 | 0.5 | 0.007 | 0.2136 | 0.428 Beta 95% CI: -0.6441-1.5001 |
Quantitative
weak
reversed effect
|
|||
|
eGFRcys
CKDGen-1000Genomes-DiscoveryMeta-eGFRcys |
Estimated glomerular filtration rate based on cystatin C eGFRcys |
MGI | C+T (GT) | Large GWAS | 49 | 0.51 | 0.0494 | 0.2137 | -0.323 Beta 95% CI: -1.3912-0.7452 |
Quantitative
weak
reversed effect
|
|||
|
CRP
prot-a-670 |
C-reactive protein |
UKB | DBSLMM | Large GWAS | 444899 | 0.51 | 0 | 18.9282 | 0.0288 Beta 95% CI: -0.0028-0.0604 |
Quantitative
weak
|
|||
|
HTN
finngen-R4-I9 |
Essential hypertension ICD-10 I10 Essential (primary) hypertension |
MGI | PRS-CS | Large GWAS | 12076 | 0.52 | 0 | 0.192 | 0.1919 | 0.5 0.491-0.509 |
0.959 OR 95% CI: 0.78-1.18 |
Binary
weak
reversed effect
|
|
|
FPG
MAGIC-FastingGlucose |
Fasting plasma glucose Fast Plasma glucose |
MGI | DBSLMM | Large GWAS | 1202301 | 0.53 | 0.0053 | 101.0744 | -0.355 Beta 95% CI: -1.0704-0.3604 |
Quantitative
weak
reversed effect
|
|||
|
Smoking
SmokingInitiation |
Smoking initiation SmokingInitiation |
MGI | DBSLMM | Large GWAS | 355 | 0.53 | 0 | 0.24 | 0.2402 | 0.496 0.489-0.504 |
0.872 OR 95% CI: 0.723-1.05 |
Binary
weak
reversed effect
|
|
|
T2D
29358691-GCST005413 |
Type 2 diabetes T2D |
MGI | DBSLMM | Large GWAS | 229 | 0.54 | 0.0001 | 0.145 | 0.1453 | 0.5 0.484-0.517 |
1.06 OR 95% CI: 0.826-1.35 |
Binary
weak
|
|
|
Cystatin C
30720-raw |
Cystatin C (mg/L) Field 30720, raw |
MGI | C+T (DS) | UK Biobank GWAS | 931 | 0.57 | 0.0434 | 0.2139 | 0.627 Beta 95% CI: -0.4706-1.7246 |
Quantitative
weak
reversed effect
|
|||
|
eGFRcys
CKDGen-1000Genomes-DiscoveryMeta-eGFRcys |
Estimated glomerular filtration rate based on cystatin C eGFRcys |
MGI | C+T (DS) | Large GWAS | 48 | 0.57 | 0.0496 | 0.2139 | -0.218 Beta 95% CI: -1.2823-0.8463 |
Quantitative
weak
reversed effect
|
|||
|
Sleep Duration
1160 |
Sleep duration |
MGI | PRS-CS | UK Biobank GWAS | 1113832 | 0.58 | 0.0001 | 0.126 | 0.1261 | 0.499 0.487-0.511 |
0.979 OR 95% CI: 0.726-1.32 |
Binary
weak
reversed effect
|
|
|
Vit B12
100013-irnt |
Vitamin B12 Field 100013, IRNT |
MGI | DBSLMM | UK Biobank GWAS | 10318270 | 0.59 | 0.0001 | 64354.8707 | 0.151 Beta 95% CI: -0.0607-0.3627 |
Quantitative
weak
reversed effect
|
|||
|
Vit B12
Wood-et-al-2013-1000G |
Vitamin B12 |
UKB | PRS-CS | Large GWAS | 1101425 | 0.59 | 0 | 19.582 | -0.035 Beta 95% CI: -0.082-0.012 |
Quantitative
weak
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Vit B12
100013-raw |
Vitamin B12 Field 100013, raw |
MGI | PRS-CS | UK Biobank GWAS | 1113819 | 0.61 | 0.0008 | 64355.3582 | 0.102 Beta 95% CI: -0.1097-0.3137 |
Quantitative
weak
|
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PUFA
MAGNETIC-otPUFA |
Polyunsaturated fatty acids |
UKB | C+T (GT) | Large GWAS | 13 | 0.61 | 0.0001 | 53.3878 | 0.0032 Beta 95% CI: -0.0437-0.05 |
Quantitative
weak
reversed effect
|
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Alcohol
DrinksPerWeek |
Drinks per week DrinksPerWeek |
MGI | DBSLMM | Large GWAS | 232 | 0.62 | 0.0001 | 2.7533 | -0.0474 Beta 95% CI: -0.1662-0.0714 |
Quantitative
weak
|
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eGFRcys
eGFRcys-overall-EA |
Estimated glomerular filtration rate based on cystatin C eGFRcys |
MGI | C+T (GT) | Large GWAS | 87 | 0.62 | 0.0551 | 0.2141 | -0.458 Beta 95% CI: -1.5576-0.6416 |
Quantitative
weak
reversed effect
|
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Vit B12
100013-raw |
Vitamin B12 Field 100013, raw |
MGI | DBSLMM | UK Biobank GWAS | 10318272 | 0.64 | 0 | 64356.0278 | -0.0865 Beta 95% CI: -0.2982-0.1252 |
Quantitative
weak
reversed effect
|
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Cystatin C
30720-irnt |
Cystatin C (IRNT) Cystatin C (quantile); Field 30720, IRNT |
MGI | C+T (GT) | UK Biobank GWAS | 415 | 0.65 | 0.0587 | 0.2142 | -0.532 Beta 95% CI: -1.5904-0.5264 |
Quantitative
weak
reversed effect
|
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Cystatin C
30720-irnt |
Cystatin C (IRNT) Cystatin C (quantile); Field 30720, IRNT |
MGI | C+T (DS) | UK Biobank GWAS | 346 | 0.66 | 0.0404 | 0.2142 | 1.05 Beta 95% CI: -0.0143-2.1143 |
Quantitative
weak
reversed effect
|
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FPG
FGovertime-corrected |
Fasting plasma glucose Fast Plasma glucose |
MGI | C+T (GT) | Large GWAS | 13 | 0.66 | 0.007 | 101.1488 | -0.0743 Beta 95% CI: -0.7877-0.6391 |
Quantitative
weak
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FPG
FGovertime-corrected |
Fasting plasma glucose Fast Plasma glucose |
MGI | DBSLMM | Large GWAS | 5106 | 0.66 | 0.0021 | 101.1508 | -0.0478 Beta 95% CI: -0.7632-0.6676 |
Quantitative
weak
reversed effect
|
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FPG
FGovertime-corrected |
Fasting plasma glucose Fast Plasma glucose |
UKB | PRS-CS | Large GWAS | 392 | 0.66 | 0 | 1.451 | 0.054 Beta 95% CI: -0.0522-0.1602 |
Quantitative
weak
reversed effect
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CRP
28887542-GCST004941 |
C-reactive protein |
UKB | PRS-CS | Large GWAS | 1119064 | 0.67 | 0 | 18.9282 | -0.0055 Beta 95% CI: -0.0371-0.0261 |
Quantitative
weak
|
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eGFRcys
eGFRcys-overall-IV-2GC |
Estimated glomerular filtration rate based on cystatin C eGFRcys |
MGI | lassosum | Large GWAS | 62133 | 0.68 | 0.0476 | 0.2142 | -0.269 Beta 95% CI: -1.347-0.809 |
Quantitative
weak
reversed effect
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Cystatin C
30720-raw |
Cystatin C (mg/L) Field 30720, raw |
MGI | DBSLMM | UK Biobank GWAS | 7451726 | 0.69 | 0.0363 | 0.2143 | 1.04 Beta 95% CI: -0.0184-2.0984 |
Quantitative
weak
reversed effect
|
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Cystatin C
30720-raw |
Cystatin C (mg/L) Field 30720, raw |
MGI | lassosum | UK Biobank GWAS | 735756 | 0.69 | 0.0684 | 0.2143 | 0.916 Beta 95% CI: -0.1581-1.9901 |
Quantitative
weak
reversed effect
|
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CRP
28887542-GCST004941 |
C-reactive protein |
MGI | lassosum | Large GWAS | 579046 | 0.7 | 0.0003 | 0.5978 | -0.0512 Beta 95% CI: -0.245-0.1426 |
Quantitative
weak
|
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HTN
I10 |
Essential hypertension (ICD-10 I10) ICD-10 I10 Essential (primary) hypertension |
MGI | DBSLMM | UK Biobank GWAS | 7094727 | 0.7 | 0 | 0.192 | 0.1919 | 0.492 0.484-0.502 |
0.928 OR 95% CI: 0.755-1.14 |
Binary
weak
|
|
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Sleep Apnea
finngen-R4-G6-SLEEPAPNO |
Sleep apnea Sleep apnoea |
UKB | C+T (GT) | Large GWAS | 688 | 0.7 | 0.0004 | 0.0107 | 0.0107 | 0.497 0.485-0.509 |
0.733 OR 95% CI: 0.521-1.03 |
Binary
weak
reversed effect
|
|
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Cystatin C
30720-raw |
Cystatin C (mg/L) Field 30720, raw |
MGI | C+T (GT) | UK Biobank GWAS | 1057 | 0.71 | 0.0531 | 0.2143 | 1.05 Beta 95% CI: -0.0143-2.1143 |
Quantitative
weak
reversed effect
|
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eGFRcys
eGFRcys-overall-IV-2GC |
Estimated glomerular filtration rate based on cystatin C eGFRcys |
MGI | DBSLMM | Large GWAS | 695827 | 0.73 | 0.0217 | 0.2144 | -0.382 Beta 95% CI: -1.458-0.694 |
Quantitative
weak
|
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Vit B12
100013-raw |
Vitamin B12 Field 100013, raw |
MGI | lassosum | UK Biobank GWAS | 313902 | 0.74 | 0.0015 | 64357.5472 | 0.16 Beta 95% CI: -0.0517-0.3717 |
Quantitative
weak
|
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Estradiol
30800-raw |
Estradiol (pmol/L) Oestradiol (pmol/L); Field 30800, raw |
MGI | C+T (DS) | UK Biobank GWAS | 4 | 0.75 | 0.0056 | 2524.4199 | -0.0334 Beta 95% CI: -0.4783-0.4115 |
Quantitative
weak
|
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FPG
FGovertime-corrected |
Fasting plasma glucose Fast Plasma glucose |
UKB | lassosum | Large GWAS | 519 | 0.76 | 0 | 1.451 | 0.0528 Beta 95% CI: -0.0534-0.159 |
Quantitative
weak
reversed effect
|
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Estradiol
30800-raw |
Estradiol (pmol/L) Oestradiol (pmol/L); Field 30800, raw |
MGI | C+T (GT) | UK Biobank GWAS | 98 | 0.8 | 0.0027 | 2524.5113 | -0.136 Beta 95% CI: -0.5809-0.3089 |
Quantitative
weak
|
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|
HTN
finngen-R4-FG |
Essential hypertension ICD-10 I10 Essential (primary) hypertension |
UKB | DBSLMM | Large GWAS | 56 | 0.8 | 0 | 0.143 | 0.1431 | 0.491 0.488-0.494 |
1.01 OR 95% CI: 0.928-1.09 |
Binary
weak
|
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Cystatin C
30720-irnt |
Cystatin C (IRNT) Cystatin C (quantile); Field 30720, IRNT |
MGI | DBSLMM | UK Biobank GWAS | 7451904 | 0.81 | 0.0202 | 0.2145 | -0.584 Beta 95% CI: -1.662-0.494 |
Quantitative
weak
reversed effect
|
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eGFRcys
eGFRcys-overall-EA |
Estimated glomerular filtration rate based on cystatin C eGFRcys |
MGI | lassosum | Large GWAS | 1954 | 0.81 | 0.0497 | 0.2145 | -0.706 Beta 95% CI: -1.7762-0.3642 |
Quantitative
weak
reversed effect
|
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Vit B12
100013-irnt |
Vitamin B12 Field 100013, IRNT |
MGI | C+T (DS) | UK Biobank GWAS | 40176 | 0.82 | 0.0017 | 64358.4861 | 0.171 Beta 95% CI: -0.0407-0.3827 |
Quantitative
weak
|
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Cystatin C
30720-raw |
Cystatin C (mg/L) Field 30720, raw |
MGI | PRS-CS | UK Biobank GWAS | 1113831 | 0.82 | 0.0709 | 0.2145 | 0.559 Beta 95% CI: -0.5092-1.6272 |
Quantitative
weak
|
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|
Cystatin C
30720-irnt |
Cystatin C (IRNT) Cystatin C (quantile); Field 30720, IRNT |
MGI | lassosum | UK Biobank GWAS | 879560 | 0.83 | 0.0817 | 0.2145 | 0.343 Beta 95% CI: -0.733-1.419 |
Quantitative
weak
reversed effect
|
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|
Vit B12
100013-raw |
Vitamin B12 Field 100013, raw |
MGI | C+T (DS) | UK Biobank GWAS | 83714 | 0.85 | 0.0011 | 64358.7081 | 0.0457 Beta 95% CI: -0.166-0.2574 |
Quantitative
weak
reversed effect
|
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HTN
20002-1072 |
Self-reported essential hypertension |
MGI | DBSLMM | UK Biobank GWAS | 7601215 | 0.86 | 0.0001 | 0.192 | 0.1919 | 0.486 0.478-0.495 |
1 OR 95% CI: 0.815-1.24 |
Binary
weak
|
|
|
eGFRcys
CKDGen-1000Genomes-DiscoveryMeta-eGFRcys |
Estimated glomerular filtration rate based on cystatin C eGFRcys |
MGI | PRS-CS | Large GWAS | 1114109 | 0.86 | 0.0275 | 0.2145 | 0.64 Beta 95% CI: -0.4654-1.7454 |
Quantitative
weak
|
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Sleep Apnea
finngen-R4-G6-SLEEPAPNO |
Sleep apnea Sleep apnoea |
UKB | lassosum | Large GWAS | 5812 | 0.86 | 0.0004 | 0.0107 | 0.0107 | 0.5 0.489-0.513 |
0.998 OR 95% CI: 0.741-1.34 |
Binary
weak
|
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Vit D
29343764-GCST005367 |
Vitamin D |
MGI | DBSLMM | Large GWAS | 98135 | 0.87 | 0 | 81.1298 | -0.112 Beta 95% CI: -0.2753-0.0513 |
Quantitative
weak
reversed effect
|
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FPG
FGovertime-corrected |
Fasting plasma glucose Fast Plasma glucose |
UKB | C+T (DS) | Large GWAS | 1479 | 0.87 | 0 | 1.451 | 0.003 Beta 95% CI: -0.1052-0.1112 |
Quantitative
weak
|
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PUFA
MAGNETIC-otPUFA |
Polyunsaturated fatty acids |
UKB | PRS-CS | Large GWAS | 1116151 | 0.89 | 0 | 53.3879 | 0.0065 Beta 95% CI: -0.0403-0.0534 |
Quantitative
weak
reversed effect
|
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|
Sleep Apnea
finngen-R4-G6-SLEEPAPNO |
Sleep apnea Sleep apnoea |
MGI | C+T (DS) | Large GWAS | 5300 | 0.89 | 0.0004 | 0.183 | 0.1825 | 0.5 0.491-0.509 |
1 OR 95% CI: 0.798-1.25 |
Binary
weak
reversed effect
|
|
|
Sleep Apnea
finngen-R4-G6-SLEEPAPNO |
Sleep apnea Sleep apnoea |
UKB | PRS-CS | Large GWAS | 12097 | 0.89 | 0 | 0.0107 | 0.0107 | 0.5 0.488-0.512 |
1.06 OR 95% CI: 0.795-1.41 |
Binary
weak
|
|
|
FPG
FGovertime-corrected |
Fasting plasma glucose Fast Plasma glucose |
UKB | C+T (GT) | Large GWAS | 1554 | 0.9 | 0 | 1.451 | -0.157 Beta 95% CI: -0.2721--0.0419 |
Quantitative
weak
reversed effect
|
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|
Vit B12
100013-irnt |
Vitamin B12 Field 100013, IRNT |
MGI | PRS-CS | UK Biobank GWAS | 1113819 | 0.91 | 0.0007 | 64359.047 | 0.015 Beta 95% CI: -0.1967-0.2267 |
Quantitative
weak
reversed effect
|
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|
Vit D
100021-raw |
Vitamin D Field 100021, raw |
MGI | DBSLMM | UK Biobank GWAS | 10318270 | 0.92 | 0.0003 | 81.13 | -0.0066 Beta 95% CI: -0.1699-0.1566 |
Quantitative
weak
reversed effect
|
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|
Vit B12
Wood-et-al-2013-1000G |
Vitamin B12 |
UKB | DBSLMM | Large GWAS | 5880 | 0.92 | 0 | 19.5821 | 0.0303 Beta 95% CI: -0.0167-0.0773 |
Quantitative
weak
reversed effect
|
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|
Vit B12
100013-irnt |
Vitamin B12 Field 100013, IRNT |
MGI | lassosum | UK Biobank GWAS | 314838 | 0.93 | 0.0007 | 64359.0983 | 0.104 Beta 95% CI: -0.1077-0.3157 |
Quantitative
weak
|
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|
FPG
FGovertime-corrected |
Fasting plasma glucose Fast Plasma glucose |
MGI | lassosum | Large GWAS | 281 | 0.96 | 0.0009 | 101.2205 | 0.0404 Beta 95% CI: -0.5182-0.599 |
Quantitative
weak
reversed effect
|
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|
Cystatin C
30720-irnt |
Cystatin C (IRNT) Cystatin C (quantile); Field 30720, IRNT |
MGI | PRS-CS | UK Biobank GWAS | 1113831 | 0.99 | 0.0638 | 0.2146 | 1.83 Beta 95% CI: 0.7775-2.8825 |
Quantitative
weak
reversed effect
|
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|
HTN
finngen-R4-I9 |
Essential hypertension ICD-10 I10 Essential (primary) hypertension |
UKB | DBSLMM | Large GWAS | 59 | 0.99 | 0 | 0.143 | 0.1431 | 0.492 0.489-0.494 |
1 OR 95% CI: 0.922-1.09 |
Binary
weak
|