Smoking initiation (MGI)

Model details

PRS IDexprsweb-smoker-yes-smokinginitiation-prscs-mgi-freeze3-20211120

Legacy IDExPRSweb_Smoker-Yes_SmokingInitiation_PRSCS_MGI-Freeze3_20211120

Legacy modelPRSCS

Catalog record ID PGS003063

Evaluation cohortMichigan Genomics Initiative Freeze 3

Trait typeBinary

SexBoth

Cases11544

Controls11788

Genome buildGRCh37/hg19

Tuning parameterauto_traitSMOKING_prefixSmokingInitiation

Reference PubMed 30643251

GWAS Summary Statistics URLhttps://conservancy.umn.edu/bitstream/handle/11299/201564/SmokingInitiation.txt.gz?sequence=34&isAllowed=y

Last updated2021-01-10

Performance summary

# SNPs1109786

P value1.1e-170

Pseudo-R²0.044

Brier score0.232

AAUC0.605

AAUC CI0.598-0.612

Percentile effect metricOR

Top percentile	OR	95% CI
1%	3.13	2.54-3.87
2%	2.58	2.23-2.98
5%	2.28	2.08-2.49
10%	2.12	1.99-2.26
25%	1.92	1.84-2.01

How to use this score page

Start with P value and the main performance metrics above to judge whether this model is useful in this cohort.
Use the top-percentile rows to see how strongly the score separates the upper PRS tail.
Use the linked PheWAS follow-up after the primary-trait evaluation, not as a substitute for it.

Flag guide: nominally significant passed the preserved release's nominal threshold; reversed effect means the observed direction ran opposite to the expected effect direction in the preserved evaluation.

Files and next steps

Start with the interactive PheWAS page to inspect notable associations for this score. Use the PRS PheWAS file for the full phenome scan, the exclusion PheWAS file for the ExPRS-specific sensitivity scan after applying this score's exposure-based exclusion rule, and the weight link when you need the score construction itself. See the Method page for metric definitions and cohort context.

Exclusion cohort: individuals without Smoking initiation.