Model details
PRS IDexprsweb-t2d-metaanalysis-diagram-plink-mgi-freeze3-20211120
Legacy IDExPRSweb_T2D_METAANALYSIS-DIAGRAM_PLINK_MGI-Freeze3_20211120
Legacy modelPLINK
Evaluation cohortMichigan Genomics Initiative Freeze 3
Trait typeBinary
SexBoth
Cases4884
Controls16472
Genome buildGRCh37/hg19
Tuning parameter5.00e-06
Last updated2021-01-10
Performance summary
# SNPs187
P value5.1e-54
Pseudo-R²0.0183
Brier score0.143
AAUC0.572
AAUC CI0.555-0.588
Percentile effect metricOR
| Top percentile |
OR |
95% CI |
| 1% | 2.12 | 1.69-2.64 |
| 2% | 1.99 | 1.69-2.33 |
| 5% | 1.77 | 1.6-1.97 |
| 10% | 1.61 | 1.49-1.74 |
| 25% | 1.55 | 1.47-1.64 |
How to use this score page
- Start with P value and the main performance metrics above to judge whether this model is useful in this cohort.
- Use the top-percentile rows to see how strongly the score separates the upper PRS tail.
- Use the linked PheWAS follow-up after the primary-trait evaluation, not as a substitute for it.
Flag guide: nominally significant passed the preserved release's nominal threshold;
reversed effect means the observed direction ran opposite to the expected effect direction in
the preserved evaluation.
Files and next steps
Start with the interactive PheWAS page to inspect notable associations for this score. Use the PRS PheWAS file
for the full phenome scan,
the exclusion PheWAS file for the ExPRS-specific sensitivity scan after applying this score's exposure-based
exclusion rule, and the weight link when you need the score construction itself.
See the Method page for metric definitions and cohort context.
Exclusion cohort: individuals without Type 2 diabetes.
Related links and downloads
