prs_id slug legacy_id legacy_model prswebprefix trait_code trait_name trait_type description cohort cohort_label method gwas_source reference_label reference_url snp_count p_value pseudo_r2 brier_score aauc aauc_ci effect_metric top_effect_1 top_effect_1_ci top_or_1 top_or_1_ci top_effect_2 top_effect_2_ci top_or_2 top_or_2_ci top_effect_5 top_effect_5_ci top_or_5 top_or_5_ci top_effect_10 top_effect_10_ci top_or_10 top_or_10_ci top_effect_25 top_effect_25_ci top_or_25 top_or_25_ci q1_vs_q2_effect q1_vs_q2_effect_ci q1_vs_q2_p_value q1_vs_q3_effect q1_vs_q3_effect_ci q1_vs_q3_p_value q1_vs_q4_effect q1_vs_q4_effect_ci q1_vs_q4_p_value nominally_significant reversed_effect_warning underpowered_warning upload_to_portal sex cases controls genome_build tuning_parameter weights_external_url weights_relpath phewas_relpath exclusion_relpath last_updated prsweb-phecode10001-ukbb-saige-hrc-x10001-p-5e-05-mgi-20200608 prsweb-phecode10001-ukbb-saige-hrc-x10001-p-5e-05-mgi-20200608 PRSWEB_PHECODE10001_UKBB-SAIGE-HRC-X10001_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE10001_UKBB-SAIGE-HRC-X10001_P_5e-05_MGI_20200608 10001 Any Cancer Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 171 0.00018 0.00134621 0.182 0.524 0.512-0.535 OR 1.15 0.802-1.65 1.15 0.802-1.65 1.13 0.871-1.46 1.13 0.871-1.46 1.2 1.02-1.41 1.2 1.02-1.41 1.14 1.01-1.28 1.14 1.01-1.28 1.14 1.05-1.24 1.14 1.05-1.24 1.04 0.933-1.15 0.503 1.09 0.981-1.21 0.109 1.19 1.07-1.32 0.0011 TRUE FALSE FALSE FALSE Both 10394 4892 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode10001-ukbb-saige-hrc-x10001-p-5e-06-mgi-20200608 prsweb-phecode10001-ukbb-saige-hrc-x10001-p-5e-06-mgi-20200608 PRSWEB_PHECODE10001_UKBB-SAIGE-HRC-X10001_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE10001_UKBB-SAIGE-HRC-X10001_P_5e-06_MGI_20200608 10001 Any Cancer Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 47 3.4e-08 0.00229561 0.182 0.529 0.518-0.54 OR 1.22 0.864-1.73 1.22 0.864-1.73 1.11 0.862-1.43 1.11 0.862-1.43 1.23 1.05-1.45 1.23 1.05-1.45 1.27 1.12-1.43 1.27 1.12-1.43 1.22 1.12-1.32 1.22 1.12-1.32 1.13 1.02-1.26 0.0233 1.19 1.07-1.33 0.00106 1.35 1.21-1.5 2.75e-08 TRUE FALSE FALSE FALSE Both 10394 4892 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode10001-ukbb-saige-hrc-x10001-p-5e-07-mgi-20200608 prsweb-phecode10001-ukbb-saige-hrc-x10001-p-5e-07-mgi-20200608 PRSWEB_PHECODE10001_UKBB-SAIGE-HRC-X10001_P_5e-07_MGI_20200608 P_5e-07 PRSWEB_PHECODE10001_UKBB-SAIGE-HRC-X10001_P_5e-07_MGI_20200608 10001 Any Cancer Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative Fixed threshold (5e-07) UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 18 2.5e-05 0.00244158 0.182 0.519 0.507-0.53 OR 1.25 0.87-1.78 1.25 0.87-1.78 1.29 1-1.65 1.29 1-1.65 1.18 1-1.39 1.18 1-1.39 1.14 1.01-1.28 1.14 1.01-1.28 1.17 1.08-1.27 1.17 1.08-1.27 1.03 0.927-1.14 0.584 1.13 1.01-1.25 0.0266 1.23 1.11-1.37 9.28e-05 TRUE FALSE FALSE FALSE Both 10394 4892 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode10001-ukbb-saige-hrc-x10001-p-5e-09-mgi-20200608 prsweb-phecode10001-ukbb-saige-hrc-x10001-p-5e-09-mgi-20200608 PRSWEB_PHECODE10001_UKBB-SAIGE-HRC-X10001_P_5e-09_MGI_20200608 P_5e-09 PRSWEB_PHECODE10001_UKBB-SAIGE-HRC-X10001_P_5e-09_MGI_20200608 10001 Any Cancer Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative Fixed threshold (5e-09) UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 10 6.7e-05 0.0028122 0.182 0.513 0.501-0.525 OR 1.19 0.825-1.72 1.19 0.825-1.72 1.33 1.03-1.71 1.33 1.03-1.71 1.27 1.08-1.5 1.27 1.08-1.5 1.27 1.13-1.43 1.27 1.13-1.43 1.15 1.05-1.25 1.15 1.05-1.25 1.07 0.96-1.18 0.232 1.07 0.966-1.19 0.185 1.2 1.08-1.33 0.000601 TRUE FALSE FALSE FALSE Both 10394 4892 GRCh37/hg19 P<=5e-09 2020-06-08 prsweb-phecode10001-ukbb-saige-hrc-x10001-p-5e-08-mgi-20200608 prsweb-phecode10001-ukbb-saige-hrc-x10001-p-5e-08-mgi-20200608 PRSWEB_PHECODE10001_UKBB-SAIGE-HRC-X10001_P_5e-08_MGI_20200608 P_5e-08 PRSWEB_PHECODE10001_UKBB-SAIGE-HRC-X10001_P_5e-08_MGI_20200608 10001 Any Cancer Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative GWAS Hits UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 14 5.1e-05 0.00274434 0.182 0.515 0.503-0.526 OR 1.48 1.04-2.1 1.48 1.04-2.1 1.32 1.03-1.7 1.32 1.03-1.7 1.2 1.01-1.41 1.2 1.01-1.41 1.21 1.07-1.36 1.21 1.07-1.36 1.19 1.09-1.29 1.19 1.09-1.29 1.04 0.94-1.16 0.418 1.1 0.99-1.22 0.0769 1.25 1.12-1.39 4.08e-05 TRUE FALSE FALSE TRUE Both 10394 4892 GRCh37/hg19 P<=5e-08 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000353/ScoringFiles/ phewas/PRSWEB_PHECODE10001_UKBB-SAIGE-HRC-X10001_P_5e-08_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE10001_UKBB-SAIGE-HRC-X10001_P_5e-08_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode10001-ukbb-saige-hrc-x10001-pt-mgi-20200608 prsweb-phecode10001-ukbb-saige-hrc-x10001-pt-mgi-20200608 PRSWEB_PHECODE10001_UKBB-SAIGE-HRC-X10001_PT_MGI_20200608 P&T PRSWEB_PHECODE10001_UKBB-SAIGE-HRC-X10001_PT_MGI_20200608 10001 Any Cancer Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative P&T UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 15 2.7e-05 0.00296649 0.182 0.517 0.506-0.527 OR 1.42 1-2.02 1.42 1-2.02 1.35 1.05-1.73 1.35 1.05-1.73 1.21 1.03-1.43 1.21 1.03-1.43 1.19 1.06-1.35 1.19 1.06-1.35 1.18 1.08-1.28 1.18 1.08-1.28 1.06 0.955-1.18 0.266 1.12 1-1.24 0.0403 1.25 1.12-1.39 3.57e-05 TRUE FALSE FALSE TRUE Both 10394 4892 GRCh37/hg19 P<=1e-07 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000355/ScoringFiles/ phewas/PRSWEB_PHECODE10001_UKBB-SAIGE-HRC-X10001_PT_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE10001_UKBB-SAIGE-HRC-X10001_PT_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode10001-ukbb-saige-hrc-x10001-prs-cs-mgi-20200608 prsweb-phecode10001-ukbb-saige-hrc-x10001-prs-cs-mgi-20200608 PRSWEB_PHECODE10001_UKBB-SAIGE-HRC-X10001_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE10001_UKBB-SAIGE-HRC-X10001_PRS-CS_MGI_20200608 10001 Any Cancer Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative PRS-CS UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1118667 6.3e-05 0.00091153 0.182 0.521 0.51-0.532 OR 1.27 0.887-1.81 1.27 0.887-1.81 1.27 0.982-1.64 1.27 0.982-1.64 1.11 0.939-1.31 1.11 0.939-1.31 1.19 1.06-1.35 1.19 1.06-1.35 1.12 1.03-1.22 1.12 1.03-1.22 1.05 0.946-1.17 0.355 1.12 1.01-1.24 0.0391 1.19 1.07-1.32 0.00113 TRUE FALSE FALSE TRUE Both 10394 4892 GRCh37/hg19 auto https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000354/ScoringFiles/ phewas/PRSWEB_PHECODE10001_UKBB-SAIGE-HRC-X10001_PRS-CS_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE10001_UKBB-SAIGE-HRC-X10001_PRS-CS_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode10001-ukbb-saige-hrc-x10001-lassosum-mgi-20200608 prsweb-phecode10001-ukbb-saige-hrc-x10001-lassosum-mgi-20200608 PRSWEB_PHECODE10001_UKBB-SAIGE-HRC-X10001_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE10001_UKBB-SAIGE-HRC-X10001_LASSOSUM_MGI_20200608 10001 Any Cancer Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative lassosum UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 179 1.5e-07 0.00368364 0.182 0.523 0.512-0.535 OR 1.61 1.14-2.27 1.61 1.14-2.27 1.27 0.986-1.63 1.27 0.986-1.63 1.26 1.07-1.48 1.26 1.07-1.48 1.27 1.13-1.43 1.27 1.13-1.43 1.21 1.11-1.32 1.21 1.11-1.32 1.12 1.01-1.25 0.0311 1.11 1-1.24 0.0492 1.31 1.18-1.45 5.89e-07 TRUE FALSE FALSE TRUE Both 10394 4892 GRCh37/hg19 s=0.2;Lambda=0.008859 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000356/ScoringFiles/ phewas/PRSWEB_PHECODE10001_UKBB-SAIGE-HRC-X10001_LASSOSUM_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE10001_UKBB-SAIGE-HRC-X10001_LASSOSUM_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode145-c3-lip-oral-pharynx-p-5e-05-mgi-20200608 prsweb-phecode145-c3-lip-oral-pharynx-p-5e-05-mgi-20200608 PRSWEB_PHECODE145_C3-LIP-ORAL-PHARYNX_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE145_C3-LIP-ORAL-PHARYNX_P_5e-05_MGI_20200608 145 Malignant neoplasm of lip, oral cavity and pharynx Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 105 0.33 0.000506359 0.0829 0.499 0.477-0.524 OR 2.13 1.14-3.97 2.13 1.14-3.97 1.52 0.912-2.54 1.52 0.912-2.54 1.31 0.919-1.86 1.31 0.919-1.86 1.1 0.839-1.45 1.1 0.839-1.45 1.06 0.871-1.29 1.06 0.871-1.29 1.08 0.85-1.37 0.531 0.92 0.719-1.18 0.509 1.06 0.836-1.35 0.622 FALSE FALSE FALSE FALSE Both 578 5750 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode145-c3-tonsil-p-5e-05-mgi-20200608 prsweb-phecode145-c3-tonsil-p-5e-05-mgi-20200608 PRSWEB_PHECODE145_C3-TONSIL_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE145_C3-TONSIL_P_5e-05_MGI_20200608 145 Malignant neoplasm of tonsil Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 56 0.84 0.000126158 0.083 0.499 0.475-0.525 OR 0.759 0.288-2 0.759 0.288-2 0.727 0.36-1.47 0.727 0.36-1.47 0.691 0.438-1.09 0.691 0.438-1.09 0.854 0.632-1.15 0.854 0.632-1.15 1.08 0.892-1.31 1.08 0.892-1.31 1.21 0.948-1.54 0.127 1.01 0.786-1.3 0.939 1.15 0.906-1.47 0.246 FALSE FALSE FALSE FALSE Both 578 5750 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode145-c3-lip-oral-pharynx-p-5e-06-mgi-20200608 prsweb-phecode145-c3-lip-oral-pharynx-p-5e-06-mgi-20200608 PRSWEB_PHECODE145_C3-LIP-ORAL-PHARYNX_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE145_C3-LIP-ORAL-PHARYNX_P_5e-06_MGI_20200608 145 Malignant neoplasm of lip, oral cavity and pharynx Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 21 0.017 0.000181997 0.0829 0.506 0.482-0.531 OR 1.79 0.918-3.49 1.79 0.918-3.49 1.51 0.904-2.52 1.51 0.904-2.52 1.31 0.918-1.86 1.31 0.918-1.86 1.32 1.02-1.71 1.32 1.02-1.71 1.22 1.01-1.47 1.22 1.01-1.47 0.964 0.75-1.24 0.777 1.09 0.855-1.39 0.48 1.25 0.982-1.58 0.0709 TRUE FALSE FALSE FALSE Both 578 5750 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode145-ukbb-saige-hrc-x145-p-5e-06-mgi-20200608 prsweb-phecode145-ukbb-saige-hrc-x145-p-5e-06-mgi-20200608 PRSWEB_PHECODE145_UKBB-SAIGE-HRC-X145_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE145_UKBB-SAIGE-HRC-X145_P_5e-06_MGI_20200608 145 Cancer of mouth Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 11 0.91 0.00014177 0.083 0.482 0.459-0.507 OR 0.943 0.389-2.28 0.943 0.389-2.28 0.997 0.54-1.84 0.997 0.54-1.84 0.877 0.579-1.33 0.877 0.579-1.33 1.09 0.828-1.44 1.09 0.828-1.44 1.01 0.826-1.22 1.01 0.826-1.22 0.929 0.729-1.18 0.553 0.997 0.785-1.27 0.98 0.976 0.768-1.24 0.839 FALSE FALSE FALSE FALSE Both 578 5750 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode145-c3-lip-oral-pharynx-pt-mgi-20200608 prsweb-phecode145-c3-lip-oral-pharynx-pt-mgi-20200608 PRSWEB_PHECODE145_C3-LIP-ORAL-PHARYNX_PT_MGI_20200608 P&T PRSWEB_PHECODE145_C3-LIP-ORAL-PHARYNX_PT_MGI_20200608 145 Malignant neoplasm of lip, oral cavity and pharynx Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative P&T UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 45 0.014 0.00158866 0.0829 0.519 0.498-0.542 OR 1.26 0.585-2.73 1.26 0.585-2.73 1.07 0.591-1.93 1.07 0.591-1.93 1.09 0.746-1.59 1.09 0.746-1.59 1.37 1.06-1.76 1.37 1.06-1.76 1.15 0.947-1.39 1.15 0.947-1.39 0.965 0.748-1.24 0.783 1.22 0.958-1.55 0.108 1.21 0.953-1.54 0.117 TRUE FALSE FALSE TRUE Both 578 5750 GRCh37/hg19 P<=2e-05 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000357/ScoringFiles/ phewas/PRSWEB_PHECODE145_C3-LIP-ORAL-PHARYNX_PT_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE145_C3-LIP-ORAL-PHARYNX_PT_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode145-ukbb-saige-hrc-x145-pt-mgi-20200608 prsweb-phecode145-ukbb-saige-hrc-x145-pt-mgi-20200608 PRSWEB_PHECODE145_UKBB-SAIGE-HRC-X145_PT_MGI_20200608 P&T PRSWEB_PHECODE145_UKBB-SAIGE-HRC-X145_PT_MGI_20200608 145 Cancer of mouth Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative P&T UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 21 0.27 0.000835988 0.0829 0.506 0.483-0.529 OR 0.774 0.294-2.04 0.774 0.294-2.04 0.822 0.421-1.6 0.822 0.421-1.6 0.737 0.471-1.15 0.737 0.471-1.15 0.941 0.703-1.26 0.941 0.703-1.26 1.03 0.846-1.25 1.03 0.846-1.25 1.32 1.03-1.7 0.0283 1.38 1.08-1.77 0.0108 1.27 0.989-1.64 0.0611 FALSE FALSE FALSE FALSE Both 578 5750 GRCh37/hg19 P<=1.26e-05 2020-06-08 prsweb-phecode145-c3-lip-oral-pharynx-prs-cs-mgi-20200608 prsweb-phecode145-c3-lip-oral-pharynx-prs-cs-mgi-20200608 PRSWEB_PHECODE145_C3-LIP-ORAL-PHARYNX_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE145_C3-LIP-ORAL-PHARYNX_PRS-CS_MGI_20200608 145 Malignant neoplasm of lip, oral cavity and pharynx Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative PRS-CS UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1092985 0.12 9.54967e-06 0.0829 0.518 0.494-0.544 OR 1.28 0.595-2.78 1.28 0.595-2.78 0.993 0.538-1.83 0.993 0.538-1.83 1.28 0.897-1.83 1.28 0.897-1.83 1.25 0.963-1.63 1.25 0.963-1.63 1.08 0.893-1.32 1.08 0.893-1.32 1.08 0.847-1.39 0.519 1.14 0.897-1.46 0.278 1.15 0.904-1.47 0.252 FALSE FALSE FALSE FALSE Both 578 5750 GRCh37/hg19 auto 2020-06-08 prsweb-phecode145-c3-tonsil-prs-cs-mgi-20200608 prsweb-phecode145-c3-tonsil-prs-cs-mgi-20200608 PRSWEB_PHECODE145_C3-TONSIL_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE145_C3-TONSIL_PRS-CS_MGI_20200608 145 Malignant neoplasm of tonsil Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative PRS-CS UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 950488 0.94 0.000611489 0.083 0.501 0.476-0.526 OR 0.935 0.386-2.26 0.935 0.386-2.26 1.17 0.658-2.07 1.17 0.658-2.07 0.869 0.574-1.32 0.869 0.574-1.32 0.993 0.747-1.32 0.993 0.747-1.32 0.989 0.812-1.21 0.989 0.812-1.21 1.08 0.844-1.37 0.557 1.08 0.846-1.37 0.541 1.04 0.813-1.33 0.764 FALSE FALSE FALSE FALSE Both 578 5750 GRCh37/hg19 auto 2020-06-08 prsweb-phecode145-ukbb-saige-hrc-x145-prs-cs-mgi-20200608 prsweb-phecode145-ukbb-saige-hrc-x145-prs-cs-mgi-20200608 PRSWEB_PHECODE145_UKBB-SAIGE-HRC-X145_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE145_UKBB-SAIGE-HRC-X145_PRS-CS_MGI_20200608 145 Cancer of mouth Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative PRS-CS UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1119238 0.012 0.000159023 0.0829 0.528 0.502-0.552 OR 1.63 0.812-3.26 1.63 0.812-3.26 1.88 1.18-3.02 1.88 1.18-3.02 1.54 1.11-2.15 1.54 1.11-2.15 1.33 1.03-1.73 1.33 1.03-1.73 1.16 0.962-1.41 1.16 0.962-1.41 1.24 0.969-1.59 0.087 1.2 0.934-1.54 0.153 1.34 1.04-1.71 0.021 TRUE FALSE FALSE TRUE Both 578 5750 GRCh37/hg19 auto https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000358/ScoringFiles/ phewas/PRSWEB_PHECODE145_UKBB-SAIGE-HRC-X145_PRS-CS_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE145_UKBB-SAIGE-HRC-X145_PRS-CS_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode145-ukbb-saige-hrc-x145-lassosum-mgi-20200608 prsweb-phecode145-ukbb-saige-hrc-x145-lassosum-mgi-20200608 PRSWEB_PHECODE145_UKBB-SAIGE-HRC-X145_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE145_UKBB-SAIGE-HRC-X145_LASSOSUM_MGI_20200608 145 Cancer of mouth Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative lassosum UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 816404 0.24 0.0021591 0.0829 0.51 0.485-0.535 OR 1.11 0.487-2.51 1.11 0.487-2.51 0.898 0.474-1.7 0.898 0.474-1.7 1.16 0.806-1.68 1.16 0.806-1.68 1.13 0.859-1.48 1.13 0.859-1.48 1.17 0.969-1.42 1.17 0.969-1.42 1.17 0.913-1.49 0.217 1.02 0.794-1.31 0.873 1.25 0.983-1.59 0.0681 FALSE FALSE FALSE FALSE Both 578 5750 GRCh37/hg19 s=1;Lambda=0.02976 2020-06-08 prsweb-phecode145-2-20001-1011-p-5e-05-mgi-20200608 prsweb-phecode145-2-20001-1011-p-5e-05-mgi-20200608 PRSWEB_PHECODE145.2_20001-1011_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE145.2_20001-1011_P_5e-05_MGI_20200608 145.2 Cancer code, self-reported: tongue cancer Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 41 0.43 1.14135e-05 0.0828 0.511 0.477-0.547 OR 0.929 0.248-3.49 0.929 0.248-3.49 0.843 0.317-2.24 0.843 0.317-2.24 1.03 0.577-1.82 1.03 0.577-1.82 0.973 0.635-1.49 0.973 0.635-1.49 0.948 0.704-1.28 0.948 0.704-1.28 1.24 0.858-1.78 0.255 1.3 0.903-1.86 0.159 1.11 0.767-1.62 0.57 FALSE FALSE FALSE FALSE Both 259 2582 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode145-2-c3-tonguenas-p-5e-05-mgi-20200608 prsweb-phecode145-2-c3-tonguenas-p-5e-05-mgi-20200608 PRSWEB_PHECODE145.2_C3-TONGUENAS_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE145.2_C3-TONGUENAS_P_5e-05_MGI_20200608 145.2 Malignant neoplasm of other and unspecified parts of tongue Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 49 0.92 0.000734753 0.0828 0.501 0.465-0.54 OR 0.556 0.105-2.96 0.556 0.105-2.96 1.04 0.425-2.53 1.04 0.425-2.53 0.786 0.414-1.49 0.786 0.414-1.49 0.93 0.603-1.44 0.93 0.603-1.44 1.09 0.82-1.46 1.09 0.82-1.46 0.768 0.529-1.12 0.166 1.01 0.708-1.43 0.974 1.01 0.712-1.43 0.952 FALSE FALSE FALSE FALSE Both 259 2582 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode145-2-c02-p-5e-06-mgi-20200608 prsweb-phecode145-2-c02-p-5e-06-mgi-20200608 PRSWEB_PHECODE145.2_C02_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE145.2_C02_P_5e-06_MGI_20200608 145.2 Diagnoses - main ICD10: C02 Malignant neoplasm of other and unspecified parts of tongue Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 7 0.15 0.000325651 0.0828 0.515 0.479-0.553 OR 3.25 1.47-7.19 3.25 1.47-7.19 2.42 1.28-4.57 2.42 1.28-4.57 1.52 0.927-2.49 1.52 0.927-2.49 1.1 0.732-1.66 1.1 0.732-1.66 1.25 0.944-1.65 1.25 0.944-1.65 0.865 0.597-1.26 0.446 0.993 0.693-1.42 0.971 1.18 0.834-1.67 0.347 FALSE FALSE FALSE FALSE Both 259 2582 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode145-2-c3-tonguenas-p-5e-06-mgi-20200608 prsweb-phecode145-2-c3-tonguenas-p-5e-06-mgi-20200608 PRSWEB_PHECODE145.2_C3-TONGUENAS_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE145.2_C3-TONGUENAS_P_5e-06_MGI_20200608 145.2 Malignant neoplasm of other and unspecified parts of tongue Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 10 0.51 0.000572047 0.0828 0.505 0.469-0.542 OR 1.71 0.618-4.76 1.71 0.618-4.76 1.64 0.78-3.43 1.64 0.78-3.43 0.946 0.522-1.71 0.946 0.522-1.71 0.928 0.601-1.43 0.928 0.601-1.43 1 0.749-1.35 1 0.749-1.35 1.37 0.948-1.99 0.0937 1.38 0.949-2 0.0922 1.26 0.861-1.83 0.237 FALSE FALSE FALSE FALSE Both 259 2582 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode145-2-ukbb-saige-hrc-x145-2-p-5e-06-mgi-20200608 prsweb-phecode145-2-ukbb-saige-hrc-x145-2-p-5e-06-mgi-20200608 PRSWEB_PHECODE145.2_UKBB-SAIGE-HRC-X145.2_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE145.2_UKBB-SAIGE-HRC-X145.2_P_5e-06_MGI_20200608 145.2 Cancer of tongue Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 8 0.24 0.000223055 0.0828 0.48 0.443-0.516 OR 2.1 0.82-5.39 2.1 0.82-5.39 1.44 0.66-3.14 1.44 0.66-3.14 1.79 1.12-2.86 1.79 1.12-2.86 1.42 0.972-2.06 1.42 0.972-2.06 0.989 0.737-1.33 0.989 0.737-1.33 1.12 0.782-1.61 0.532 1.09 0.761-1.57 0.626 1.08 0.749-1.55 0.684 FALSE FALSE FALSE FALSE Both 259 2582 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode145-2-20001-1011-prs-cs-mgi-20200608 prsweb-phecode145-2-20001-1011-prs-cs-mgi-20200608 PRSWEB_PHECODE145.2_20001-1011_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE145.2_20001-1011_PRS-CS_MGI_20200608 145.2 Cancer code, self-reported: tongue cancer Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative PRS-CS UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 868459 0.86 0.00035225 0.0828 0.502 0.468-0.54 OR 0 0-0 0 0-0 0.658 0.22-1.97 0.658 0.22-1.97 1.03 0.58-1.83 1.03 0.58-1.83 0.976 0.636-1.5 0.976 0.636-1.5 1.05 0.784-1.4 1.05 0.784-1.4 1.16 0.814-1.65 0.412 0.921 0.636-1.34 0.665 1.07 0.747-1.53 0.715 FALSE FALSE FALSE FALSE Both 259 2582 GRCh37/hg19 auto 2020-06-08 prsweb-phecode145-2-c01-prs-cs-mgi-20200608 prsweb-phecode145-2-c01-prs-cs-mgi-20200608 PRSWEB_PHECODE145.2_C01_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE145.2_C01_PRS-CS_MGI_20200608 145.2 Diagnoses - main ICD10: C01 Malignant neoplasm of base of tongue Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative PRS-CS UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 854886 0.31 0.000216279 0.0828 0.523 0.488-0.558 OR 0.922 0.246-3.46 0.922 0.246-3.46 0.839 0.316-2.23 0.839 0.316-2.23 0.556 0.264-1.17 0.556 0.264-1.17 0.847 0.54-1.33 0.847 0.54-1.33 1.2 0.905-1.59 1.2 0.905-1.59 1.2 0.831-1.75 0.325 1.18 0.812-1.71 0.385 1.34 0.93-1.92 0.117 FALSE FALSE FALSE FALSE Both 259 2582 GRCh37/hg19 auto 2020-06-08 prsweb-phecode145-2-c02-prs-cs-mgi-20200608 prsweb-phecode145-2-c02-prs-cs-mgi-20200608 PRSWEB_PHECODE145.2_C02_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE145.2_C02_PRS-CS_MGI_20200608 145.2 Diagnoses - main ICD10: C02 Malignant neoplasm of other and unspecified parts of tongue Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative PRS-CS UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 951586 0.15 0.00063011 0.0828 0.526 0.49-0.563 OR 1.68 0.606-4.68 1.68 0.606-4.68 1.22 0.534-2.8 1.22 0.534-2.8 1.6 0.985-2.6 1.6 0.985-2.6 1.32 0.898-1.94 1.32 0.898-1.94 1.27 0.96-1.68 1.27 0.96-1.68 1.28 0.891-1.85 0.18 1 0.682-1.47 0.998 1.37 0.956-1.96 0.0862 FALSE FALSE FALSE FALSE Both 259 2582 GRCh37/hg19 auto 2020-06-08 prsweb-phecode145-2-c3-tonguenas-prs-cs-mgi-20200608 prsweb-phecode145-2-c3-tonguenas-prs-cs-mgi-20200608 PRSWEB_PHECODE145.2_C3-TONGUENAS_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE145.2_C3-TONGUENAS_PRS-CS_MGI_20200608 145.2 Malignant neoplasm of other and unspecified parts of tongue Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative PRS-CS UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 931954 0.04 0.00324804 0.0827 0.538 0.501-0.575 OR 1.69 0.61-4.71 1.69 0.61-4.71 1.03 0.423-2.52 1.03 0.423-2.52 1.43 0.866-2.38 1.43 0.866-2.38 1.32 0.9-1.94 1.32 0.9-1.94 1.29 0.98-1.71 1.29 0.98-1.71 1.08 0.741-1.58 0.681 1.2 0.829-1.74 0.333 1.42 0.987-2.03 0.0588 TRUE FALSE FALSE TRUE Both 259 2582 GRCh37/hg19 auto https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000359/ScoringFiles/ phewas/PRSWEB_PHECODE145.2_C3-TONGUENAS_PRS-CS_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE145.2_C3-TONGUENAS_PRS-CS_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode145-2-ukbb-saige-hrc-x145-2-prs-cs-mgi-20200608 prsweb-phecode145-2-ukbb-saige-hrc-x145-2-prs-cs-mgi-20200608 PRSWEB_PHECODE145.2_UKBB-SAIGE-HRC-X145.2_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE145.2_UKBB-SAIGE-HRC-X145.2_PRS-CS_MGI_20200608 145.2 Cancer of tongue Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative PRS-CS UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1119238 0.38 1.10533e-05 0.0828 0.523 0.486-0.559 OR 0.928 0.247-3.48 0.928 0.247-3.48 0.842 0.317-2.24 0.842 0.317-2.24 0.939 0.517-1.7 0.939 0.517-1.7 1.01 0.663-1.54 1.01 0.663-1.54 1.11 0.834-1.48 1.11 0.834-1.48 1.07 0.735-1.55 0.736 1.25 0.871-1.8 0.225 1.22 0.849-1.76 0.281 FALSE FALSE FALSE FALSE Both 259 2582 GRCh37/hg19 auto 2020-06-08 prsweb-phecode145-2-20001-1011-lassosum-mgi-20200608 prsweb-phecode145-2-20001-1011-lassosum-mgi-20200608 PRSWEB_PHECODE145.2_20001-1011_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE145.2_20001-1011_LASSOSUM_MGI_20200608 145.2 Cancer code, self-reported: tongue cancer Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative lassosum UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1826297 0.27 0.00310801 0.0828 0.514 0.479-0.55 OR 0.562 0.105-3 0.562 0.105-3 1.24 0.542-2.85 1.24 0.542-2.85 1.44 0.87-2.39 1.44 0.87-2.39 1.32 0.901-1.94 1.32 0.901-1.94 0.988 0.736-1.33 0.988 0.736-1.33 0.931 0.645-1.34 0.703 1.12 0.791-1.6 0.515 0.994 0.693-1.43 0.974 FALSE FALSE FALSE FALSE Both 259 2582 GRCh37/hg19 s=1;Lambda=0.02336 2020-06-08 prsweb-phecode145-2-c01-lassosum-mgi-20200608 prsweb-phecode145-2-c01-lassosum-mgi-20200608 PRSWEB_PHECODE145.2_C01_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE145.2_C01_LASSOSUM_MGI_20200608 145.2 Diagnoses - main ICD10: C01 Malignant neoplasm of base of tongue Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative lassosum UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1312025 0.36 0.00120516 0.0828 0.52 0.484-0.554 OR 0.939 0.251-3.51 0.939 0.251-3.51 1.04 0.426-2.53 1.04 0.426-2.53 1.02 0.574-1.81 1.02 0.574-1.81 1.06 0.698-1.6 1.06 0.698-1.6 1.09 0.818-1.45 1.09 0.818-1.45 1.07 0.739-1.55 0.721 1.18 0.82-1.69 0.376 1.17 0.812-1.67 0.405 FALSE FALSE FALSE FALSE Both 259 2582 GRCh37/hg19 s=1;Lambda=0.03793 2020-06-08 prsweb-phecode145-2-c02-lassosum-mgi-20200608 prsweb-phecode145-2-c02-lassosum-mgi-20200608 PRSWEB_PHECODE145.2_C02_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE145.2_C02_LASSOSUM_MGI_20200608 145.2 Diagnoses - main ICD10: C02 Malignant neoplasm of other and unspecified parts of tongue Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative lassosum UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 2318649 0.097 0.00146725 0.0828 0.535 0.496-0.571 OR 0 0-0 0 0-0 0.659 0.221-1.97 0.659 0.221-1.97 1.11 0.635-1.94 1.11 0.635-1.94 1.15 0.765-1.71 1.15 0.765-1.71 1.2 0.906-1.59 1.2 0.906-1.59 1.05 0.721-1.53 0.802 1.22 0.845-1.75 0.293 1.29 0.902-1.85 0.162 FALSE FALSE FALSE FALSE Both 259 2582 GRCh37/hg19 s=1;Lambda=0.01833 2020-06-08 prsweb-phecode145-2-c3-tonguenas-lassosum-mgi-20200608 prsweb-phecode145-2-c3-tonguenas-lassosum-mgi-20200608 PRSWEB_PHECODE145.2_C3-TONGUENAS_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE145.2_C3-TONGUENAS_LASSOSUM_MGI_20200608 145.2 Malignant neoplasm of other and unspecified parts of tongue Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative lassosum UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 12655 0.14 0.00408069 0.0828 0.523 0.489-0.558 OR 2.09 0.815-5.34 2.09 0.815-5.34 1.62 0.774-3.4 1.62 0.774-3.4 1.03 0.578-1.83 1.03 0.578-1.83 1.02 0.667-1.55 1.02 0.667-1.55 1.09 0.818-1.45 1.09 0.818-1.45 1.45 1.01-2.08 0.0424 1.09 0.745-1.6 0.65 1.28 0.886-1.86 0.187 FALSE FALSE FALSE FALSE Both 259 2582 GRCh37/hg19 s=0.5;Lambda=0.1 2020-06-08 prsweb-phecode145-2-ukbb-saige-hrc-x145-2-lassosum-mgi-20200608 prsweb-phecode145-2-ukbb-saige-hrc-x145-2-lassosum-mgi-20200608 PRSWEB_PHECODE145.2_UKBB-SAIGE-HRC-X145.2_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE145.2_UKBB-SAIGE-HRC-X145.2_LASSOSUM_MGI_20200608 145.2 Cancer of tongue Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative lassosum UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 4854389 0.65 0.000702296 0.0828 0.513 0.474-0.55 OR 0.939 0.251-3.52 0.939 0.251-3.52 0.84 0.316-2.23 0.84 0.316-2.23 0.787 0.414-1.5 0.787 0.414-1.5 0.97 0.633-1.49 0.97 0.633-1.49 1.01 0.75-1.35 1.01 0.75-1.35 0.864 0.597-1.25 0.439 1.14 0.805-1.62 0.46 0.994 0.695-1.42 0.972 FALSE FALSE FALSE FALSE Both 259 2582 GRCh37/hg19 s=0.5;Lambda=0.001274 2020-06-08 prsweb-phecode145-3-ukbb-saige-hrc-x145-3-p-5e-05-mgi-20200608 prsweb-phecode145-3-ukbb-saige-hrc-x145-3-p-5e-05-mgi-20200608 PRSWEB_PHECODE145.3_UKBB-SAIGE-HRC-X145.3_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE145.3_UKBB-SAIGE-HRC-X145.3_P_5e-05_MGI_20200608 145.3 Cancer of major salivary glands Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 81 0.96 0.000643679 0.0826 0.494 0.448-0.544 OR 0.861 0.155-4.77 0.861 0.155-4.77 1.66 0.659-4.19 1.66 0.659-4.19 1.57 0.843-2.91 1.57 0.843-2.91 1.44 0.896-2.3 1.44 0.896-2.3 1.05 0.732-1.52 1.05 0.732-1.52 0.9 0.567-1.43 0.653 1.07 0.687-1.68 0.755 1.01 0.647-1.59 0.953 FALSE FALSE FALSE FALSE Both 162 1620 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode145-5-ukbb-saige-hrc-x145-5-prs-cs-mgi-20200608 prsweb-phecode145-5-ukbb-saige-hrc-x145-5-prs-cs-mgi-20200608 PRSWEB_PHECODE145.5_UKBB-SAIGE-HRC-X145.5_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE145.5_UKBB-SAIGE-HRC-X145.5_PRS-CS_MGI_20200608 145.5 Cancer of the mouth floor Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative PRS-CS UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1119238 0.64 0.0035113 0.0826 0.515 0.441-0.586 OR 2.65 0.612-11.4 2.65 0.612-11.4 3.08 1.14-8.32 3.08 1.14-8.32 1.99 0.921-4.28 1.99 0.921-4.28 1.75 0.957-3.19 1.75 0.957-3.19 1.35 0.841-2.17 1.35 0.841-2.17 0.743 0.393-1.4 0.36 0.86 0.467-1.58 0.629 1.19 0.665-2.13 0.559 FALSE FALSE FALSE FALSE Both 88 880 GRCh37/hg19 auto 2020-06-08 prsweb-phecode149-ukbb-saige-hrc-x149-p-5e-05-mgi-20200608 prsweb-phecode149-ukbb-saige-hrc-x149-p-5e-05-mgi-20200608 PRSWEB_PHECODE149_UKBB-SAIGE-HRC-X149_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE149_UKBB-SAIGE-HRC-X149_P_5e-05_MGI_20200608 149 Cancer of larynx, pharynx, nasal cavities Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 84 0.24 1.27319e-05 0.0828 0.509 0.483-0.535 OR 1.16 0.511-2.64 1.16 0.511-2.64 1.4 0.816-2.4 1.4 0.816-2.4 1.21 0.836-1.75 1.21 0.836-1.75 1.09 0.825-1.45 1.09 0.825-1.45 1.19 0.983-1.45 1.19 0.983-1.45 0.943 0.735-1.21 0.646 0.936 0.729-1.2 0.602 1.13 0.894-1.44 0.3 FALSE FALSE FALSE FALSE Both 560 5585 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode149-ukbb-saige-hrc-x149-p-5e-06-mgi-20200608 prsweb-phecode149-ukbb-saige-hrc-x149-p-5e-06-mgi-20200608 PRSWEB_PHECODE149_UKBB-SAIGE-HRC-X149_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE149_UKBB-SAIGE-HRC-X149_P_5e-06_MGI_20200608 149 Cancer of larynx, pharynx, nasal cavities Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 11 0.69 1.14034e-05 0.0828 0.48 0.456-0.506 OR 0.977 0.403-2.37 0.977 0.403-2.37 1.38 0.807-2.37 1.38 0.807-2.37 1.2 0.83-1.74 1.2 0.83-1.74 1.23 0.94-1.61 1.23 0.94-1.61 1.18 0.974-1.43 1.18 0.974-1.43 1.06 0.835-1.34 0.644 0.66 0.506-0.86 0.00209 1.07 0.848-1.36 0.557 FALSE FALSE FALSE FALSE Both 560 5585 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode149-ukbb-saige-hrc-x149-pt-mgi-20200608 prsweb-phecode149-ukbb-saige-hrc-x149-pt-mgi-20200608 PRSWEB_PHECODE149_UKBB-SAIGE-HRC-X149_PT_MGI_20200608 P&T PRSWEB_PHECODE149_UKBB-SAIGE-HRC-X149_PT_MGI_20200608 149 Cancer of larynx, pharynx, nasal cavities Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative P&T UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 24 0.26 0.000271462 0.0828 0.501 0.476-0.526 OR 1.68 0.835-3.37 1.68 0.835-3.37 1.01 0.547-1.87 1.01 0.547-1.87 1.05 0.71-1.55 1.05 0.71-1.55 1.12 0.853-1.48 1.12 0.853-1.48 1.04 0.852-1.27 1.04 0.852-1.27 0.831 0.644-1.07 0.156 1.13 0.894-1.44 0.301 1.03 0.808-1.31 0.809 FALSE FALSE FALSE FALSE Both 560 5585 GRCh37/hg19 P<=1e-05 2020-06-08 prsweb-phecode149-ukbb-saige-hrc-x149-prs-cs-mgi-20200608 prsweb-phecode149-ukbb-saige-hrc-x149-prs-cs-mgi-20200608 PRSWEB_PHECODE149_UKBB-SAIGE-HRC-X149_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE149_UKBB-SAIGE-HRC-X149_PRS-CS_MGI_20200608 149 Cancer of larynx, pharynx, nasal cavities Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative PRS-CS UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1119238 0.055 0.000204883 0.0827 0.525 0.5-0.55 OR 1.5 0.722-3.11 1.5 0.722-3.11 1.28 0.735-2.23 1.28 0.735-2.23 1.39 0.982-1.97 1.39 0.982-1.97 1.29 0.989-1.68 1.29 0.989-1.68 1.15 0.945-1.39 1.15 0.945-1.39 1.14 0.882-1.46 0.325 1.16 0.901-1.49 0.251 1.26 0.986-1.62 0.0647 FALSE FALSE FALSE FALSE Both 560 5585 GRCh37/hg19 auto 2020-06-08 prsweb-phecode149-ukbb-saige-hrc-x149-lassosum-mgi-20200608 prsweb-phecode149-ukbb-saige-hrc-x149-lassosum-mgi-20200608 PRSWEB_PHECODE149_UKBB-SAIGE-HRC-X149_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE149_UKBB-SAIGE-HRC-X149_LASSOSUM_MGI_20200608 149 Cancer of larynx, pharynx, nasal cavities Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative lassosum UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1881193 0.22 0.000872129 0.0828 0.519 0.495-0.544 OR 0.8 0.303-2.11 0.8 0.303-2.11 1.11 0.615-2.01 1.11 0.615-2.01 0.944 0.627-1.42 0.944 0.627-1.42 1.01 0.757-1.35 1.01 0.757-1.35 1.08 0.891-1.32 1.08 0.891-1.32 1.14 0.885-1.47 0.312 1.23 0.957-1.57 0.107 1.22 0.947-1.56 0.125 FALSE FALSE FALSE FALSE Both 560 5585 GRCh37/hg19 s=0.2;Lambda=0.004281 2020-06-08 prsweb-phecode149-1-ukbb-saige-hrc-x149-1-p-5e-05-mgi-20200608 prsweb-phecode149-1-ukbb-saige-hrc-x149-1-p-5e-05-mgi-20200608 PRSWEB_PHECODE149.1_UKBB-SAIGE-HRC-X149.1_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE149.1_UKBB-SAIGE-HRC-X149.1_P_5e-05_MGI_20200608 149.1 Cancer of oropharynx Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 77 0.69 0.00496104 0.083 0.502 0.452-0.552 OR 1.02 0.181-5.75 1.02 0.181-5.75 0.862 0.231-3.22 0.862 0.231-3.22 0.767 0.317-1.85 0.767 0.317-1.85 0.885 0.484-1.62 0.885 0.484-1.62 1.2 0.814-1.76 1.2 0.814-1.76 1.35 0.831-2.2 0.225 0.926 0.544-1.58 0.776 1.26 0.773-2.06 0.351 FALSE FALSE FALSE FALSE Both 137 1362 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode149-1-ukbb-saige-hrc-x149-1-pt-mgi-20200608 prsweb-phecode149-1-ukbb-saige-hrc-x149-1-pt-mgi-20200608 PRSWEB_PHECODE149.1_UKBB-SAIGE-HRC-X149.1_PT_MGI_20200608 P&T PRSWEB_PHECODE149.1_UKBB-SAIGE-HRC-X149.1_PT_MGI_20200608 149.1 Cancer of oropharynx Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative P&T UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 77 0.69 0.00496104 0.083 0.502 0.452-0.552 OR 1.02 0.181-5.75 1.02 0.181-5.75 0.862 0.231-3.22 0.862 0.231-3.22 0.767 0.317-1.85 0.767 0.317-1.85 0.885 0.484-1.62 0.885 0.484-1.62 1.2 0.814-1.76 1.2 0.814-1.76 1.35 0.831-2.2 0.225 0.926 0.544-1.58 0.776 1.26 0.773-2.06 0.351 FALSE FALSE FALSE FALSE Both 137 1362 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode149-1-ukbb-saige-hrc-x149-1-prs-cs-mgi-20200608 prsweb-phecode149-1-ukbb-saige-hrc-x149-1-prs-cs-mgi-20200608 PRSWEB_PHECODE149.1_UKBB-SAIGE-HRC-X149.1_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE149.1_UKBB-SAIGE-HRC-X149.1_PRS-CS_MGI_20200608 149.1 Cancer of oropharynx Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative PRS-CS UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1119238 0.86 0.000410492 0.083 0.508 0.457-0.558 OR 1.71 0.427-6.85 1.71 0.427-6.85 1.57 0.569-4.36 1.57 0.569-4.36 1.22 0.586-2.55 1.22 0.586-2.55 1.38 0.818-2.31 1.38 0.818-2.31 1.07 0.723-1.6 1.07 0.723-1.6 1.13 0.687-1.86 0.631 1.12 0.683-1.85 0.648 1.16 0.706-1.91 0.558 FALSE FALSE FALSE FALSE Both 137 1362 GRCh37/hg19 auto 2020-06-08 prsweb-phecode149-1-c09-lassosum-mgi-20200608 prsweb-phecode149-1-c09-lassosum-mgi-20200608 PRSWEB_PHECODE149.1_C09_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE149.1_C09_LASSOSUM_MGI_20200608 149.1 Diagnoses - main ICD10: C09 Malignant neoplasm of tonsil Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative lassosum UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 41255 0.95 0.00160282 0.083 0.497 0.447-0.546 OR 2.48 0.735-8.36 2.48 0.735-8.36 1.97 0.769-5.06 1.97 0.769-5.06 1.38 0.686-2.79 1.38 0.686-2.79 1.13 0.649-1.97 1.13 0.649-1.97 0.883 0.584-1.33 0.883 0.584-1.33 1.13 0.7-1.81 0.624 0.928 0.563-1.53 0.768 0.904 0.548-1.49 0.693 FALSE FALSE FALSE FALSE Both 137 1362 GRCh37/hg19 s=1;Lambda=0.1 2020-06-08 prsweb-phecode149-1-ukbb-saige-hrc-x149-1-lassosum-mgi-20200608 prsweb-phecode149-1-ukbb-saige-hrc-x149-1-lassosum-mgi-20200608 PRSWEB_PHECODE149.1_UKBB-SAIGE-HRC-X149.1_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE149.1_UKBB-SAIGE-HRC-X149.1_LASSOSUM_MGI_20200608 149.1 Cancer of oropharynx Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative lassosum UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 442201 0.56 0.00256852 0.083 0.515 0.464-0.561 OR 2.41 0.715-8.1 2.41 0.715-8.1 2.31 0.96-5.57 2.31 0.96-5.57 1.37 0.682-2.77 1.37 0.682-2.77 1.21 0.705-2.08 1.21 0.705-2.08 1.03 0.694-1.54 1.03 0.694-1.54 0.984 0.595-1.63 0.949 1.22 0.748-1.98 0.429 1.12 0.683-1.84 0.652 FALSE FALSE FALSE FALSE Both 137 1362 GRCh37/hg19 s=0.9;Lambda=0.04833 2020-06-08 prsweb-phecode149-4-20001-1006-p-5e-05-mgi-20200608 prsweb-phecode149-4-20001-1006-p-5e-05-mgi-20200608 PRSWEB_PHECODE149.4_20001-1006_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE149.4_20001-1006_P_5e-05_MGI_20200608 149.4 Cancer code, self-reported: larynx/throat cancer Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 72 0.87 0.00108064 0.0826 0.506 0.464-0.552 OR 1.51 0.383-5.95 1.51 0.383-5.95 0.758 0.205-2.8 0.758 0.205-2.8 0.805 0.357-1.82 0.805 0.357-1.82 0.768 0.423-1.4 0.768 0.423-1.4 1.02 0.706-1.49 1.02 0.706-1.49 0.997 0.624-1.59 0.991 1.15 0.733-1.81 0.537 1.05 0.665-1.67 0.823 FALSE FALSE FALSE FALSE Both 158 1580 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode149-4-c3-larynx-p-5e-05-mgi-20200608 prsweb-phecode149-4-c3-larynx-p-5e-05-mgi-20200608 PRSWEB_PHECODE149.4_C3-LARYNX_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE149.4_C3-LARYNX_P_5e-05_MGI_20200608 149.4 Malignant neoplasm of larynx Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 65 0.092 0.000351515 0.0825 0.521 0.476-0.565 OR 4.7 1.91-11.5 4.7 1.91-11.5 3.41 1.65-7.07 3.41 1.65-7.07 1.78 0.968-3.26 1.78 0.968-3.26 1.41 0.866-2.28 1.41 0.866-2.28 1.24 0.867-1.79 1.24 0.867-1.79 0.658 0.404-1.07 0.0912 0.951 0.61-1.48 0.824 1.09 0.707-1.7 0.685 FALSE FALSE FALSE FALSE Both 158 1580 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode149-4-c32-p-5e-05-mgi-20200608 prsweb-phecode149-4-c32-p-5e-05-mgi-20200608 PRSWEB_PHECODE149.4_C32_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE149.4_C32_P_5e-05_MGI_20200608 149.4 Diagnoses - main ICD10: C32 Malignant neoplasm of larynx Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 56 0.65 0.000213295 0.0826 0.51 0.461-0.557 OR 3.39 1.24-9.26 3.39 1.24-9.26 1.7 0.67-4.3 1.7 0.67-4.3 1.48 0.777-2.81 1.48 0.777-2.81 1.41 0.87-2.28 1.41 0.87-2.28 0.959 0.657-1.4 0.959 0.657-1.4 0.953 0.593-1.53 0.841 1.27 0.813-1.99 0.293 1.03 0.647-1.65 0.893 FALSE FALSE FALSE FALSE Both 158 1580 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode149-4-ukbb-saige-hrc-x149-4-p-5e-05-mgi-20200608 prsweb-phecode149-4-ukbb-saige-hrc-x149-4-p-5e-05-mgi-20200608 PRSWEB_PHECODE149.4_UKBB-SAIGE-HRC-X149.4_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE149.4_UKBB-SAIGE-HRC-X149.4_P_5e-05_MGI_20200608 149.4 Cancer of larynx Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 72 0.17 0.000522893 0.0826 0.53 0.484-0.577 OR 1.52 0.385-5.97 1.52 0.385-5.97 0.765 0.207-2.83 0.765 0.207-2.83 0.68 0.283-1.64 0.68 0.283-1.64 1.04 0.611-1.78 1.04 0.611-1.78 1.2 0.839-1.73 1.2 0.839-1.73 1.34 0.815-2.21 0.248 1.64 1.01-2.66 0.0451 1.63 1.01-2.65 0.0473 FALSE FALSE FALSE FALSE Both 158 1580 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode149-4-20001-1006-p-5e-06-mgi-20200608 prsweb-phecode149-4-20001-1006-p-5e-06-mgi-20200608 PRSWEB_PHECODE149.4_20001-1006_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE149.4_20001-1006_P_5e-06_MGI_20200608 149.4 Cancer code, self-reported: larynx/throat cancer Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 11 0.78 0.00130816 0.0826 0.493 0.447-0.54 OR 2.12 0.645-6.97 2.12 0.645-6.97 1.07 0.349-3.3 1.07 0.349-3.3 0.934 0.434-2.01 0.934 0.434-2.01 0.97 0.562-1.68 0.97 0.562-1.68 1.02 0.704-1.49 1.02 0.704-1.49 1.12 0.715-1.76 0.616 0.978 0.614-1.56 0.926 1.05 0.663-1.66 0.835 FALSE FALSE FALSE FALSE Both 158 1580 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode149-4-c3-larynx-p-5e-06-mgi-20200608 prsweb-phecode149-4-c3-larynx-p-5e-06-mgi-20200608 PRSWEB_PHECODE149.4_C3-LARYNX_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE149.4_C3-LARYNX_P_5e-06_MGI_20200608 149.4 Malignant neoplasm of larynx Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 15 0.22 0.00315669 0.0826 0.517 0.468-0.567 OR 2.16 0.656-7.12 2.16 0.656-7.12 1.4 0.514-3.84 1.4 0.514-3.84 1.78 0.97-3.26 1.78 0.97-3.26 1.34 0.817-2.2 1.34 0.817-2.2 1.21 0.842-1.74 1.21 0.842-1.74 1.06 0.666-1.68 0.816 0.941 0.587-1.51 0.8 1.18 0.755-1.86 0.462 FALSE FALSE FALSE FALSE Both 158 1580 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode149-4-c32-p-5e-06-mgi-20200608 prsweb-phecode149-4-c32-p-5e-06-mgi-20200608 PRSWEB_PHECODE149.4_C32_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE149.4_C32_P_5e-06_MGI_20200608 149.4 Diagnoses - main ICD10: C32 Malignant neoplasm of larynx Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 15 0.77 8.9575e-05 0.0826 0.501 0.451-0.55 OR 2.12 0.642-7 2.12 0.642-7 1.38 0.503-3.77 1.38 0.503-3.77 0.934 0.435-2.01 0.934 0.435-2.01 1.04 0.61-1.77 1.04 0.61-1.77 1.13 0.783-1.63 1.13 0.783-1.63 0.809 0.501-1.31 0.385 1.13 0.726-1.77 0.58 1.09 0.695-1.71 0.71 FALSE FALSE FALSE FALSE Both 158 1580 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode149-4-c32-pt-mgi-20200608 prsweb-phecode149-4-c32-pt-mgi-20200608 PRSWEB_PHECODE149.4_C32_PT_MGI_20200608 P&T PRSWEB_PHECODE149.4_C32_PT_MGI_20200608 149.4 Diagnoses - main ICD10: C32 Malignant neoplasm of larynx Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative P&T UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 106 0.44 0.00181696 0.0826 0.518 0.472-0.567 OR 2.16 0.642-7.25 2.16 0.642-7.25 1.39 0.504-3.86 1.39 0.504-3.86 1.48 0.778-2.82 1.48 0.778-2.82 0.906 0.516-1.59 0.906 0.516-1.59 1.2 0.838-1.72 1.2 0.838-1.72 0.962 0.599-1.55 0.874 1.12 0.704-1.77 0.638 1.24 0.792-1.96 0.343 FALSE FALSE FALSE FALSE Both 158 1580 GRCh37/hg19 P<=9.82e-05 2020-06-08 prsweb-phecode149-4-ukbb-saige-hrc-x149-4-pt-mgi-20200608 prsweb-phecode149-4-ukbb-saige-hrc-x149-4-pt-mgi-20200608 PRSWEB_PHECODE149.4_UKBB-SAIGE-HRC-X149.4_PT_MGI_20200608 P&T PRSWEB_PHECODE149.4_UKBB-SAIGE-HRC-X149.4_PT_MGI_20200608 149.4 Cancer of larynx Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative P&T UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 53 0.025 0.00182003 0.0824 0.543 0.494-0.59 OR 1.52 0.384-5.98 1.52 0.384-5.98 0.764 0.207-2.82 0.764 0.207-2.82 1.47 0.776-2.8 1.47 0.776-2.8 1.11 0.66-1.87 1.11 0.66-1.87 1.36 0.953-1.93 1.36 0.953-1.93 1.48 0.902-2.44 0.12 1.5 0.909-2.47 0.113 1.78 1.1-2.88 0.019 TRUE FALSE FALSE TRUE Both 158 1580 GRCh37/hg19 P<=3.98e-05 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000362/ScoringFiles/ phewas/PRSWEB_PHECODE149.4_UKBB-SAIGE-HRC-X149.4_PT_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE149.4_UKBB-SAIGE-HRC-X149.4_PT_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode149-4-c3-larynx-prs-cs-mgi-20200608 prsweb-phecode149-4-c3-larynx-prs-cs-mgi-20200608 PRSWEB_PHECODE149.4_C3-LARYNX_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE149.4_C3-LARYNX_PRS-CS_MGI_20200608 149.4 Malignant neoplasm of larynx Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative PRS-CS UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 978910 0.44 0.000973724 0.0826 0.526 0.479-0.571 OR 0 0-0 0 0-0 1.07 0.348-3.29 1.07 0.348-3.29 0.935 0.435-2.01 0.935 0.435-2.01 0.899 0.513-1.58 0.899 0.513-1.58 1.06 0.731-1.53 1.06 0.731-1.53 0.937 0.572-1.54 0.798 1.51 0.962-2.37 0.0729 1.26 0.788-2.02 0.334 FALSE FALSE FALSE FALSE Both 158 1580 GRCh37/hg19 auto 2020-06-08 prsweb-phecode149-4-c32-prs-cs-mgi-20200608 prsweb-phecode149-4-c32-prs-cs-mgi-20200608 PRSWEB_PHECODE149.4_C32_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE149.4_C32_PRS-CS_MGI_20200608 149.4 Diagnoses - main ICD10: C32 Malignant neoplasm of larynx Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative PRS-CS UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 967720 0.19 0.000580688 0.0826 0.532 0.487-0.58 OR 0.905 0.162-5.05 0.905 0.162-5.05 0.455 0.0867-2.39 0.455 0.0867-2.39 1.2 0.599-2.39 1.2 0.599-2.39 0.966 0.559-1.67 0.966 0.559-1.67 1.13 0.781-1.62 1.13 0.781-1.62 1.36 0.84-2.2 0.211 1.43 0.888-2.3 0.141 1.38 0.861-2.22 0.181 FALSE FALSE FALSE FALSE Both 158 1580 GRCh37/hg19 auto 2020-06-08 prsweb-phecode149-4-ukbb-saige-hrc-x149-4-prs-cs-mgi-20200608 prsweb-phecode149-4-ukbb-saige-hrc-x149-4-prs-cs-mgi-20200608 PRSWEB_PHECODE149.4_UKBB-SAIGE-HRC-X149.4_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE149.4_UKBB-SAIGE-HRC-X149.4_PRS-CS_MGI_20200608 149.4 Cancer of larynx Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative PRS-CS UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1119238 0.73 0.000161474 0.0826 0.508 0.464-0.556 OR 0 0-0 0 0-0 0.454 0.087-2.37 0.454 0.087-2.37 1.07 0.518-2.21 1.07 0.518-2.21 1.19 0.712-1.98 1.19 0.712-1.98 0.96 0.656-1.4 0.96 0.656-1.4 1.18 0.745-1.86 0.486 1.09 0.686-1.73 0.719 1.11 0.694-1.78 0.66 FALSE FALSE FALSE FALSE Both 158 1580 GRCh37/hg19 auto 2020-06-08 prsweb-phecode149-4-c3-larynx-lassosum-mgi-20200608 prsweb-phecode149-4-c3-larynx-lassosum-mgi-20200608 PRSWEB_PHECODE149.4_C3-LARYNX_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE149.4_C3-LARYNX_LASSOSUM_MGI_20200608 149.4 Malignant neoplasm of larynx Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative lassosum UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 87893 0.033 0.00197245 0.0824 0.55 0.504-0.593 OR 1.51 0.382-5.94 1.51 0.382-5.94 1.71 0.675-4.32 1.71 0.675-4.32 1.47 0.777-2.8 1.47 0.777-2.8 1.18 0.709-1.97 1.18 0.709-1.97 1.32 0.924-1.88 1.32 0.924-1.88 1.92 1.15-3.22 0.0128 1.82 1.08-3.06 0.0245 2.2 1.32-3.67 0.00236 TRUE FALSE FALSE TRUE Both 158 1580 GRCh37/hg19 s=1;Lambda=0.07848 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000361/ScoringFiles/ phewas/PRSWEB_PHECODE149.4_C3-LARYNX_LASSOSUM_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE149.4_C3-LARYNX_LASSOSUM_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode149-4-c32-lassosum-mgi-20200608 prsweb-phecode149-4-c32-lassosum-mgi-20200608 PRSWEB_PHECODE149.4_C32_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE149.4_C32_LASSOSUM_MGI_20200608 149.4 Diagnoses - main ICD10: C32 Malignant neoplasm of larynx Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative lassosum UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 25920 0.0027 0.00677471 0.0822 0.57 0.522-0.618 OR 2.14 0.649-7.06 2.14 0.649-7.06 2.36 1.04-5.35 2.36 1.04-5.35 1.75 0.958-3.19 1.75 0.958-3.19 1.4 0.864-2.27 1.4 0.864-2.27 1.61 1.14-2.27 1.61 1.14-2.27 1.25 0.745-2.11 0.393 1.72 1.05-2.83 0.0323 2.09 1.29-3.39 0.00264 TRUE FALSE FALSE TRUE Both 158 1580 GRCh37/hg19 s=0.9;Lambda=0.1 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000360/ScoringFiles/ phewas/PRSWEB_PHECODE149.4_C32_LASSOSUM_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE149.4_C32_LASSOSUM_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode149-4-ukbb-saige-hrc-x149-4-lassosum-mgi-20200608 prsweb-phecode149-4-ukbb-saige-hrc-x149-4-lassosum-mgi-20200608 PRSWEB_PHECODE149.4_UKBB-SAIGE-HRC-X149.4_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE149.4_UKBB-SAIGE-HRC-X149.4_LASSOSUM_MGI_20200608 149.4 Cancer of larynx Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative lassosum UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 175596 0.11 0.0027602 0.0825 0.534 0.486-0.578 OR 2.14 0.649-7.03 2.14 0.649-7.03 2.7 1.24-5.92 2.7 1.24-5.92 1.9 1.06-3.42 1.9 1.06-3.42 1.41 0.868-2.28 1.41 0.868-2.28 1.4 0.984-1.99 1.4 0.984-1.99 1.07 0.67-1.7 0.786 0.82 0.501-1.34 0.43 1.32 0.844-2.06 0.224 FALSE FALSE FALSE FALSE Both 158 1580 GRCh37/hg19 s=0.9;Lambda=0.06158 2020-06-08 prsweb-phecode149-9-ukbb-saige-hrc-x149-9-p-5e-05-mgi-20200608 prsweb-phecode149-9-ukbb-saige-hrc-x149-9-p-5e-05-mgi-20200608 PRSWEB_PHECODE149.9_UKBB-SAIGE-HRC-X149.9_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE149.9_UKBB-SAIGE-HRC-X149.9_P_5e-05_MGI_20200608 149.9 Cancer of of nasal cavities Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 49 0.65 4.05705e-06 0.0828 0.5 0.434-0.56 OR 1.55 0.253-9.54 1.55 0.253-9.54 1.32 0.34-5.15 1.32 0.34-5.15 1.44 0.614-3.38 1.44 0.614-3.38 1.29 0.672-2.47 1.29 0.672-2.47 1.03 0.635-1.69 1.03 0.635-1.69 0.731 0.383-1.4 0.342 1.17 0.649-2.1 0.605 1.05 0.573-1.91 0.882 FALSE FALSE FALSE FALSE Both 90 897 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode149-9-ukbb-saige-hrc-x149-9-pt-mgi-20200608 prsweb-phecode149-9-ukbb-saige-hrc-x149-9-pt-mgi-20200608 PRSWEB_PHECODE149.9_UKBB-SAIGE-HRC-X149.9_PT_MGI_20200608 P&T PRSWEB_PHECODE149.9_UKBB-SAIGE-HRC-X149.9_PT_MGI_20200608 149.9 Cancer of of nasal cavities Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative P&T UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 6 0.72 0.00236496 0.0829 0.486 0.424-0.552 OR 0 0-0 0 0-0 0.785 0.143-4.31 0.785 0.143-4.31 0.743 0.245-2.25 0.743 0.245-2.25 1.43 0.758-2.71 1.43 0.758-2.71 1.37 0.861-2.19 1.37 0.861-2.19 0.497 0.254-0.972 0.0411 0.72 0.402-1.29 0.27 0.989 0.575-1.7 0.967 FALSE FALSE FALSE FALSE Both 90 897 GRCh37/hg19 P<=1e-05 2020-06-08 prsweb-phecode150-20001-1017-p-5e-05-mgi-20200608 prsweb-phecode150-20001-1017-p-5e-05-mgi-20200608 PRSWEB_PHECODE150_20001-1017_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE150_20001-1017_P_5e-05_MGI_20200608 150 Cancer code, self-reported: oesophageal cancer Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 60 0.89 0.00112702 0.0828 0.502 0.46-0.543 OR 0 0-0 0 0-0 0.908 0.299-2.76 0.908 0.299-2.76 1.45 0.802-2.62 1.45 0.802-2.62 1.09 0.672-1.76 1.09 0.672-1.76 1.04 0.737-1.46 1.04 0.737-1.46 1.4 0.927-2.12 0.109 0.974 0.624-1.52 0.908 1.14 0.74-1.74 0.561 FALSE FALSE FALSE FALSE Both 188 1876 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode150-c15-p-5e-05-mgi-20200608 prsweb-phecode150-c15-p-5e-05-mgi-20200608 PRSWEB_PHECODE150_C15_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE150_C15_P_5e-05_MGI_20200608 150 Diagnoses - main ICD10: C15 Malignant neoplasm of oesophagus Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 109 0.0047 0.00187595 0.0825 0.555 0.514-0.596 OR 2.3 0.798-6.63 2.3 0.798-6.63 2.22 1.03-4.79 2.22 1.03-4.79 1.56 0.876-2.77 1.56 0.876-2.77 1.33 0.85-2.09 1.33 0.85-2.09 1.41 1.02-1.95 1.41 1.02-1.95 1.35 0.851-2.14 0.203 1.53 0.976-2.39 0.064 1.76 1.14-2.73 0.0112 TRUE FALSE FALSE FALSE Both 188 1876 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode150-c3-oesophagus-p-5e-05-mgi-20200608 prsweb-phecode150-c3-oesophagus-p-5e-05-mgi-20200608 PRSWEB_PHECODE150_C3-OESOPHAGUS_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE150_C3-OESOPHAGUS_P_5e-05_MGI_20200608 150 Malignant neoplasm of oesophagus Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 96 0.26 3.52269e-05 0.0827 0.529 0.483-0.568 OR 1.28 0.331-4.96 1.28 0.331-4.96 0.903 0.296-2.75 0.903 0.296-2.75 1 0.505-1.99 1 0.505-1.99 1.1 0.677-1.78 1.1 0.677-1.78 1.22 0.874-1.7 1.22 0.874-1.7 1.05 0.681-1.63 0.817 1.13 0.737-1.73 0.575 1.28 0.842-1.94 0.249 FALSE FALSE FALSE FALSE Both 188 1876 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode150-gwas-catalog-r2019-05-03-x150-p-5e-05-mgi-20200608 prsweb-phecode150-gwas-catalog-r2019-05-03-x150-p-5e-05-mgi-20200608 PRSWEB_PHECODE150_GWAS-Catalog-r2019-05-03-X150_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE150_GWAS-Catalog-r2019-05-03-X150_P_5e-05_MGI_20200608 150 Esophageal adenocarcinoma Binary 8 unique SNPs MGI Michigan Genomics Initiative Fixed threshold (5e-05) GWAS Catalog (2019-05-03) 24121790 https://www.ncbi.nlm.nih.gov/pubmed/?term=24121790 7 0.71 0.000294309 0.0828 0.517 0.476-0.562 OR 0.769 0.14-4.21 0.769 0.14-4.21 0.907 0.298-2.76 0.907 0.298-2.76 1.69 0.962-2.95 1.69 0.962-2.95 1.52 0.989-2.34 1.52 0.989-2.34 1.21 0.872-1.69 1.21 0.872-1.69 0.982 0.64-1.51 0.933 0.983 0.641-1.51 0.939 1.24 0.819-1.87 0.31 FALSE FALSE FALSE FALSE Both 188 1876 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode150-ukbb-saige-hrc-x150-p-5e-05-mgi-20200608 prsweb-phecode150-ukbb-saige-hrc-x150-p-5e-05-mgi-20200608 PRSWEB_PHECODE150_UKBB-SAIGE-HRC-X150_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE150_UKBB-SAIGE-HRC-X150_P_5e-05_MGI_20200608 150 Cancer of esophagus Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 105 0.51 0.000256789 0.0828 0.51 0.472-0.555 OR 1.27 0.328-4.89 1.27 0.328-4.89 1.15 0.426-3.13 1.15 0.426-3.13 1.44 0.798-2.6 1.44 0.798-2.6 0.964 0.584-1.59 0.964 0.584-1.59 1.06 0.754-1.49 1.06 0.754-1.49 0.963 0.622-1.49 0.866 1.24 0.818-1.88 0.31 1.14 0.741-1.74 0.558 FALSE FALSE FALSE FALSE Both 188 1876 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode150-20001-1017-p-5e-06-mgi-20200608 prsweb-phecode150-20001-1017-p-5e-06-mgi-20200608 PRSWEB_PHECODE150_20001-1017_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE150_20001-1017_P_5e-06_MGI_20200608 150 Cancer code, self-reported: oesophageal cancer Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 10 0.17 0.00317397 0.0827 0.52 0.478-0.565 OR 0.764 0.14-4.16 0.764 0.14-4.16 1.16 0.431-3.14 1.16 0.431-3.14 1.1 0.573-2.13 1.1 0.573-2.13 1.03 0.629-1.68 1.03 0.629-1.68 1.09 0.781-1.53 1.09 0.781-1.53 1.2 0.777-1.86 0.408 1.33 0.866-2.04 0.193 1.27 0.828-1.96 0.27 FALSE FALSE FALSE FALSE Both 188 1876 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode150-c15-p-5e-06-mgi-20200608 prsweb-phecode150-c15-p-5e-06-mgi-20200608 PRSWEB_PHECODE150_C15_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE150_C15_P_5e-06_MGI_20200608 150 Diagnoses - main ICD10: C15 Malignant neoplasm of oesophagus Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 25 0.53 0.00122208 0.0828 0.51 0.462-0.551 OR 0 0-0 0 0-0 0.911 0.299-2.77 0.911 0.299-2.77 0.78 0.366-1.67 0.78 0.366-1.67 1.15 0.718-1.85 1.15 0.718-1.85 1.06 0.757-1.49 1.06 0.757-1.49 1.26 0.822-1.93 0.289 1.15 0.747-1.77 0.524 1.18 0.771-1.82 0.439 FALSE FALSE FALSE FALSE Both 188 1876 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode150-gwas-catalog-r2019-05-03-x150-p-5e-06-mgi-20200608 prsweb-phecode150-gwas-catalog-r2019-05-03-x150-p-5e-06-mgi-20200608 PRSWEB_PHECODE150_GWAS-Catalog-r2019-05-03-X150_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE150_GWAS-Catalog-r2019-05-03-X150_P_5e-06_MGI_20200608 150 Esophageal adenocarcinoma Binary 8 unique SNPs MGI Michigan Genomics Initiative Fixed threshold (5e-06) GWAS Catalog (2019-05-03) 24121790 https://www.ncbi.nlm.nih.gov/pubmed/?term=24121790 7 0.71 0.000294309 0.0828 0.517 0.476-0.562 OR 0.769 0.14-4.21 0.769 0.14-4.21 0.907 0.298-2.76 0.907 0.298-2.76 1.69 0.962-2.95 1.69 0.962-2.95 1.52 0.989-2.34 1.52 0.989-2.34 1.21 0.872-1.69 1.21 0.872-1.69 0.982 0.64-1.51 0.933 0.983 0.641-1.51 0.939 1.24 0.819-1.87 0.31 FALSE FALSE FALSE FALSE Both 188 1876 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode150-ukbb-saige-hrc-x150-p-5e-06-mgi-20200608 prsweb-phecode150-ukbb-saige-hrc-x150-p-5e-06-mgi-20200608 PRSWEB_PHECODE150_UKBB-SAIGE-HRC-X150_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE150_UKBB-SAIGE-HRC-X150_P_5e-06_MGI_20200608 150 Cancer of esophagus Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 7 0.75 0.000160455 0.0828 0.462 0.425-0.502 OR 1.79 0.556-5.78 1.79 0.556-5.78 1.43 0.574-3.57 1.43 0.574-3.57 1.57 0.885-2.79 1.57 0.885-2.79 1.09 0.674-1.76 1.09 0.674-1.76 0.924 0.651-1.31 0.924 0.651-1.31 0.817 0.536-1.25 0.349 0.911 0.598-1.39 0.663 0.826 0.54-1.26 0.377 FALSE FALSE FALSE FALSE Both 188 1876 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode150-20001-1017-pt-mgi-20200608 prsweb-phecode150-20001-1017-pt-mgi-20200608 PRSWEB_PHECODE150_20001-1017_PT_MGI_20200608 P&T PRSWEB_PHECODE150_20001-1017_PT_MGI_20200608 150 Cancer code, self-reported: oesophageal cancer Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative P&T UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 24 0.2 0.00593107 0.0827 0.519 0.479-0.559 OR 1.78 0.551-5.73 1.78 0.551-5.73 1.16 0.428-3.13 1.16 0.428-3.13 0.993 0.501-1.97 0.993 0.501-1.97 1.03 0.627-1.68 1.03 0.627-1.68 1.12 0.802-1.57 1.12 0.802-1.57 1.44 0.928-2.22 0.104 1.34 0.862-2.09 0.191 1.4 0.902-2.17 0.134 FALSE FALSE FALSE FALSE Both 188 1876 GRCh37/hg19 P<=1.58e-05 2020-06-08 prsweb-phecode150-c15-pt-mgi-20200608 prsweb-phecode150-c15-pt-mgi-20200608 PRSWEB_PHECODE150_C15_PT_MGI_20200608 P&T PRSWEB_PHECODE150_C15_PT_MGI_20200608 150 Diagnoses - main ICD10: C15 Malignant neoplasm of oesophagus Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative P&T UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 62 0.15 0.00286636 0.0827 0.532 0.486-0.57 OR 1.27 0.329-4.91 1.27 0.329-4.91 0.638 0.175-2.33 0.638 0.175-2.33 0.89 0.434-1.82 0.89 0.434-1.82 1.03 0.63-1.68 1.03 0.63-1.68 1.28 0.923-1.78 1.28 0.923-1.78 1.12 0.715-1.74 0.629 1.24 0.804-1.91 0.331 1.44 0.937-2.2 0.0964 FALSE FALSE FALSE FALSE Both 188 1876 GRCh37/hg19 P<=2.51e-05 2020-06-08 prsweb-phecode150-c3-oesophagus-pt-mgi-20200608 prsweb-phecode150-c3-oesophagus-pt-mgi-20200608 PRSWEB_PHECODE150_C3-OESOPHAGUS_PT_MGI_20200608 P&T PRSWEB_PHECODE150_C3-OESOPHAGUS_PT_MGI_20200608 150 Malignant neoplasm of oesophagus Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative P&T UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 143 0.094 0.00186688 0.0827 0.538 0.492-0.577 OR 0 0-0 0 0-0 1.18 0.435-3.18 1.18 0.435-3.18 0.673 0.3-1.51 0.673 0.3-1.51 1.09 0.675-1.77 1.09 0.675-1.77 1.38 0.998-1.9 1.38 0.998-1.9 0.821 0.524-1.29 0.39 1.08 0.705-1.64 0.733 1.35 0.898-2.02 0.149 FALSE FALSE FALSE FALSE Both 188 1876 GRCh37/hg19 P<=7.94e-05 2020-06-08 prsweb-phecode150-gwas-catalog-r2019-05-03-x150-pt-mgi-20200608 prsweb-phecode150-gwas-catalog-r2019-05-03-x150-pt-mgi-20200608 PRSWEB_PHECODE150_GWAS-Catalog-r2019-05-03-X150_PT_MGI_20200608 P&T PRSWEB_PHECODE150_GWAS-Catalog-r2019-05-03-X150_PT_MGI_20200608 150 Esophageal adenocarcinoma Binary 8 unique SNPs MGI Michigan Genomics Initiative P&T GWAS Catalog (2019-05-03) 24121790 https://www.ncbi.nlm.nih.gov/pubmed/?term=24121790 7 0.71 0.000294309 0.0828 0.517 0.476-0.562 OR 0.769 0.14-4.21 0.769 0.14-4.21 0.907 0.298-2.76 0.907 0.298-2.76 1.69 0.962-2.95 1.69 0.962-2.95 1.52 0.989-2.34 1.52 0.989-2.34 1.21 0.872-1.69 1.21 0.872-1.69 0.982 0.64-1.51 0.933 0.983 0.641-1.51 0.939 1.24 0.819-1.87 0.31 FALSE FALSE FALSE FALSE Both 188 1876 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode150-ukbb-saige-hrc-x150-pt-mgi-20200608 prsweb-phecode150-ukbb-saige-hrc-x150-pt-mgi-20200608 PRSWEB_PHECODE150_UKBB-SAIGE-HRC-X150_PT_MGI_20200608 P&T PRSWEB_PHECODE150_UKBB-SAIGE-HRC-X150_PT_MGI_20200608 150 Cancer of esophagus Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative P&T UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 45 0.8 0.00215333 0.0828 0.504 0.465-0.548 OR 1.27 0.329-4.92 1.27 0.329-4.92 0.898 0.295-2.73 0.898 0.295-2.73 1.11 0.574-2.13 1.11 0.574-2.13 1.09 0.671-1.76 1.09 0.671-1.76 1 0.711-1.41 1 0.711-1.41 0.987 0.64-1.52 0.954 1.19 0.788-1.8 0.405 1.06 0.695-1.63 0.773 FALSE FALSE FALSE FALSE Both 188 1876 GRCh37/hg19 P<=2.51e-05 2020-06-08 prsweb-phecode150-20001-1017-prs-cs-mgi-20200608 prsweb-phecode150-20001-1017-prs-cs-mgi-20200608 PRSWEB_PHECODE150_20001-1017_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE150_20001-1017_PRS-CS_MGI_20200608 150 Cancer code, self-reported: oesophageal cancer Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative PRS-CS UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 934591 0.068 0.000755737 0.0827 0.535 0.493-0.579 OR 1.79 0.556-5.77 1.79 0.556-5.77 1.42 0.572-3.55 1.42 0.572-3.55 1.22 0.65-2.3 1.22 0.65-2.3 1.15 0.716-1.84 1.15 0.716-1.84 1.04 0.737-1.46 1.04 0.737-1.46 1.76 1.12-2.76 0.0136 1.7 1.08-2.67 0.0221 1.56 0.985-2.48 0.0582 FALSE FALSE FALSE FALSE Both 188 1876 GRCh37/hg19 auto 2020-06-08 prsweb-phecode150-c15-prs-cs-mgi-20200608 prsweb-phecode150-c15-prs-cs-mgi-20200608 PRSWEB_PHECODE150_C15_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE150_C15_PRS-CS_MGI_20200608 150 Diagnoses - main ICD10: C15 Malignant neoplasm of oesophagus Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative PRS-CS UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1081646 0.0036 0.00344085 0.0825 0.564 0.525-0.604 OR 2.84 1.07-7.54 2.84 1.07-7.54 1.7 0.727-3.99 1.7 0.727-3.99 1.22 0.651-2.3 1.22 0.651-2.3 1.34 0.853-2.09 1.34 0.853-2.09 1.38 0.998-1.91 1.38 0.998-1.91 1.98 1.23-3.2 0.00501 1.98 1.22-3.21 0.00543 2.19 1.36-3.5 0.00113 TRUE FALSE FALSE TRUE Both 188 1876 GRCh37/hg19 auto https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000363/ScoringFiles/ phewas/PRSWEB_PHECODE150_C15_PRS-CS_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE150_C15_PRS-CS_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode150-c3-oesophagus-prs-cs-mgi-20200608 prsweb-phecode150-c3-oesophagus-prs-cs-mgi-20200608 PRSWEB_PHECODE150_C3-OESOPHAGUS_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE150_C3-OESOPHAGUS_PRS-CS_MGI_20200608 150 Malignant neoplasm of oesophagus Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative PRS-CS UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1070434 0.026 0.0039263 0.0826 0.553 0.514-0.596 OR 1.27 0.329-4.9 1.27 0.329-4.9 1.17 0.433-3.17 1.17 0.433-3.17 0.999 0.503-1.99 0.999 0.503-1.99 1.33 0.851-2.09 1.33 0.851-2.09 1.12 0.803-1.57 1.12 0.803-1.57 1.23 0.78-1.94 0.374 1.65 1.07-2.54 0.023 1.43 0.919-2.22 0.113 TRUE FALSE FALSE TRUE Both 188 1876 GRCh37/hg19 auto https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000365/ScoringFiles/ phewas/PRSWEB_PHECODE150_C3-OESOPHAGUS_PRS-CS_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE150_C3-OESOPHAGUS_PRS-CS_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode150-ukbb-saige-hrc-x150-prs-cs-mgi-20200608 prsweb-phecode150-ukbb-saige-hrc-x150-prs-cs-mgi-20200608 PRSWEB_PHECODE150_UKBB-SAIGE-HRC-X150_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE150_UKBB-SAIGE-HRC-X150_PRS-CS_MGI_20200608 150 Cancer of esophagus Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative PRS-CS UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1119238 0.005 0.000445815 0.0825 0.564 0.522-0.605 OR 1.28 0.332-4.95 1.28 0.332-4.95 1.44 0.577-3.58 1.44 0.577-3.58 1.45 0.803-2.63 1.45 0.803-2.63 1.27 0.802-2 1.27 0.802-2 1.41 1.02-1.94 1.41 1.02-1.94 1.43 0.905-2.28 0.125 1.51 0.956-2.37 0.0772 1.85 1.19-2.87 0.00643 TRUE FALSE FALSE TRUE Both 188 1876 GRCh37/hg19 auto https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000366/ScoringFiles/ phewas/PRSWEB_PHECODE150_UKBB-SAIGE-HRC-X150_PRS-CS_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE150_UKBB-SAIGE-HRC-X150_PRS-CS_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode150-20001-1017-lassosum-mgi-20200608 prsweb-phecode150-20001-1017-lassosum-mgi-20200608 PRSWEB_PHECODE150_20001-1017_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE150_20001-1017_LASSOSUM_MGI_20200608 150 Cancer code, self-reported: oesophageal cancer Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative lassosum UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 406747 0.28 0.00375339 0.0827 0.519 0.478-0.563 OR 1.79 0.557-5.78 1.79 0.557-5.78 1.42 0.571-3.55 1.42 0.571-3.55 1.22 0.649-2.29 1.22 0.649-2.29 1.03 0.63-1.68 1.03 0.63-1.68 1.01 0.714-1.42 1.01 0.714-1.42 1.24 0.801-1.93 0.331 1.47 0.956-2.25 0.0796 1.23 0.791-1.91 0.36 FALSE FALSE FALSE FALSE Both 188 1876 GRCh37/hg19 s=1;Lambda=0.06158 2020-06-08 prsweb-phecode150-c15-lassosum-mgi-20200608 prsweb-phecode150-c15-lassosum-mgi-20200608 PRSWEB_PHECODE150_C15_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE150_C15_LASSOSUM_MGI_20200608 150 Diagnoses - main ICD10: C15 Malignant neoplasm of oesophagus Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative lassosum UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 2001 0.012 0.00421728 0.0826 0.551 0.51-0.588 OR 1.81 0.56-5.82 1.81 0.56-5.82 1.44 0.576-3.58 1.44 0.576-3.58 1.22 0.652-2.3 1.22 0.652-2.3 1.47 0.946-2.27 1.47 0.946-2.27 1.6 1.16-2.19 1.6 1.16-2.19 1.53 0.989-2.38 0.0563 1.01 0.627-1.62 0.969 1.83 1.2-2.81 0.00549 TRUE FALSE FALSE TRUE Both 188 1876 GRCh37/hg19 s=1;Lambda=0.07848 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000364/ScoringFiles/ phewas/PRSWEB_PHECODE150_C15_LASSOSUM_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE150_C15_LASSOSUM_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode150-c3-oesophagus-lassosum-mgi-20200608 prsweb-phecode150-c3-oesophagus-lassosum-mgi-20200608 PRSWEB_PHECODE150_C3-OESOPHAGUS_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE150_C3-OESOPHAGUS_LASSOSUM_MGI_20200608 150 Malignant neoplasm of oesophagus Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative lassosum UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 91277 0.24 0.00646968 0.0827 0.531 0.494-0.57 OR 0 0-0 0 0-0 0.641 0.175-2.35 0.641 0.175-2.35 0.566 0.237-1.35 0.566 0.237-1.35 0.798 0.466-1.37 0.798 0.466-1.37 1.15 0.826-1.61 1.15 0.826-1.61 1.84 1.18-2.88 0.00743 1.5 0.946-2.39 0.0844 1.69 1.07-2.66 0.0254 FALSE FALSE FALSE FALSE Both 188 1876 GRCh37/hg19 s=0.9;Lambda=0.04833 2020-06-08 prsweb-phecode150-ukbb-saige-hrc-x150-lassosum-mgi-20200608 prsweb-phecode150-ukbb-saige-hrc-x150-lassosum-mgi-20200608 PRSWEB_PHECODE150_UKBB-SAIGE-HRC-X150_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE150_UKBB-SAIGE-HRC-X150_LASSOSUM_MGI_20200608 150 Cancer of esophagus Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative lassosum UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 64075 0.85 0.00246914 0.0828 0.502 0.457-0.546 OR 2.31 0.803-6.66 2.31 0.803-6.66 1.17 0.431-3.17 1.17 0.431-3.17 1.22 0.647-2.29 1.22 0.647-2.29 1.2 0.756-1.91 1.2 0.756-1.91 0.977 0.692-1.38 0.977 0.692-1.38 0.933 0.613-1.42 0.748 1.05 0.69-1.58 0.834 0.953 0.627-1.45 0.821 FALSE FALSE FALSE FALSE Both 188 1876 GRCh37/hg19 s=1;Lambda=0.04833 2020-06-08 prsweb-phecode150-gwas-catalog-r2019-05-03-x150-p-5e-05-ukb-20200608 prsweb-phecode150-gwas-catalog-r2019-05-03-x150-p-5e-05-ukb-20200608 PRSWEB_PHECODE150_GWAS-Catalog-r2019-05-03-X150_P_5e-05_UKB_20200608 P_5e-05 PRSWEB_PHECODE150_GWAS-Catalog-r2019-05-03-X150_P_5e-05_UKB_20200608 150 Esophageal adenocarcinoma Binary 8 unique SNPs UKB UK Biobank Fixed threshold (5e-05) GWAS Catalog (2019-05-03) 24121790 https://www.ncbi.nlm.nih.gov/pubmed/?term=24121790 7 0.81 0.000889536 0.0826 0.503 0.472-0.532 OR 3.33 1.78-6.25 3.33 1.78-6.25 1.82 1.05-3.17 1.82 1.05-3.17 1.35 0.896-2.04 1.35 0.896-2.04 1.27 0.933-1.74 1.27 0.933-1.74 1.08 0.854-1.36 1.08 0.854-1.36 0.933 0.7-1.24 0.633 0.88 0.658-1.18 0.389 1.03 0.779-1.37 0.822 FALSE FALSE FALSE FALSE Both 405 4054 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode150-gwas-catalog-r2019-05-03-x150-p-5e-06-ukb-20200608 prsweb-phecode150-gwas-catalog-r2019-05-03-x150-p-5e-06-ukb-20200608 PRSWEB_PHECODE150_GWAS-Catalog-r2019-05-03-X150_P_5e-06_UKB_20200608 P_5e-06 PRSWEB_PHECODE150_GWAS-Catalog-r2019-05-03-X150_P_5e-06_UKB_20200608 150 Esophageal adenocarcinoma Binary 8 unique SNPs UKB UK Biobank Fixed threshold (5e-06) GWAS Catalog (2019-05-03) 24121790 https://www.ncbi.nlm.nih.gov/pubmed/?term=24121790 7 0.81 0.000889536 0.0826 0.503 0.472-0.532 OR 3.33 1.78-6.25 3.33 1.78-6.25 1.82 1.05-3.17 1.82 1.05-3.17 1.35 0.896-2.04 1.35 0.896-2.04 1.27 0.933-1.74 1.27 0.933-1.74 1.08 0.854-1.36 1.08 0.854-1.36 0.933 0.7-1.24 0.633 0.88 0.658-1.18 0.389 1.03 0.779-1.37 0.822 FALSE FALSE FALSE FALSE Both 405 4054 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode150-gwas-catalog-r2019-05-03-x150-pt-ukb-20200608 prsweb-phecode150-gwas-catalog-r2019-05-03-x150-pt-ukb-20200608 PRSWEB_PHECODE150_GWAS-Catalog-r2019-05-03-X150_PT_UKB_20200608 P&T PRSWEB_PHECODE150_GWAS-Catalog-r2019-05-03-X150_PT_UKB_20200608 150 Esophageal adenocarcinoma Binary 8 unique SNPs UKB UK Biobank P&T GWAS Catalog (2019-05-03) 24121790 https://www.ncbi.nlm.nih.gov/pubmed/?term=24121790 7 0.81 0.000889536 0.0826 0.503 0.472-0.532 OR 3.33 1.78-6.25 3.33 1.78-6.25 1.82 1.05-3.17 1.82 1.05-3.17 1.35 0.896-2.04 1.35 0.896-2.04 1.27 0.933-1.74 1.27 0.933-1.74 1.08 0.854-1.36 1.08 0.854-1.36 0.933 0.7-1.24 0.633 0.88 0.658-1.18 0.389 1.03 0.779-1.37 0.822 FALSE FALSE FALSE FALSE Both 405 4054 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode151-ukbb-saige-hrc-x151-p-5e-05-mgi-20200608 prsweb-phecode151-ukbb-saige-hrc-x151-p-5e-05-mgi-20200608 PRSWEB_PHECODE151_UKBB-SAIGE-HRC-X151_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE151_UKBB-SAIGE-HRC-X151_P_5e-05_MGI_20200608 151 Cancer of stomach Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 76 0.25 4.26842e-06 0.0828 0.519 0.477-0.56 OR 0.655 0.121-3.53 0.655 0.121-3.53 1.97 0.925-4.18 1.97 0.925-4.18 1.28 0.711-2.29 1.28 0.711-2.29 1.22 0.786-1.88 1.22 0.786-1.88 1.28 0.938-1.74 1.28 0.938-1.74 1.02 0.682-1.54 0.907 1 0.666-1.51 0.991 1.24 0.838-1.83 0.285 FALSE FALSE FALSE FALSE Both 212 2112 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode151-20001-1018-pt-mgi-20200608 prsweb-phecode151-20001-1018-pt-mgi-20200608 PRSWEB_PHECODE151_20001-1018_PT_MGI_20200608 P&T PRSWEB_PHECODE151_20001-1018_PT_MGI_20200608 151 Cancer code, self-reported: stomach cancer Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative P&T UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 6 0.89 0.00106406 0.0829 0.504 0.459-0.544 OR 0 0-0 0 0-0 0.796 0.264-2.4 0.796 0.264-2.4 0.688 0.324-1.46 0.688 0.324-1.46 1.01 0.632-1.61 1.01 0.632-1.61 1.19 0.869-1.62 1.19 0.869-1.62 0.916 0.611-1.37 0.673 0.981 0.658-1.46 0.926 1.14 0.775-1.68 0.507 FALSE FALSE FALSE FALSE Both 212 2112 GRCh37/hg19 P<=1e-05 2020-06-08 prsweb-phecode151-20001-1018-prs-cs-mgi-20200608 prsweb-phecode151-20001-1018-prs-cs-mgi-20200608 PRSWEB_PHECODE151_20001-1018_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE151_20001-1018_PRS-CS_MGI_20200608 151 Cancer code, self-reported: stomach cancer Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative PRS-CS UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 889207 0.62 0.00052864 0.0829 0.507 0.463-0.546 OR 1.55 0.489-4.91 1.55 0.489-4.91 1.97 0.929-4.19 1.97 0.929-4.19 1.37 0.776-2.42 1.37 0.776-2.42 1.21 0.785-1.88 1.21 0.785-1.88 0.929 0.668-1.29 0.929 0.668-1.29 0.699 0.461-1.06 0.0913 1.14 0.784-1.65 0.498 0.877 0.592-1.3 0.514 FALSE FALSE FALSE FALSE Both 212 2112 GRCh37/hg19 auto 2020-06-08 prsweb-phecode151-20001-1018-lassosum-mgi-20200608 prsweb-phecode151-20001-1018-lassosum-mgi-20200608 PRSWEB_PHECODE151_20001-1018_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE151_20001-1018_LASSOSUM_MGI_20200608 151 Cancer code, self-reported: stomach cancer Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative lassosum UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 63785 0.36 0.00239619 0.0829 0.518 0.477-0.56 OR 2.47 0.945-6.46 2.47 0.945-6.46 1.5 0.645-3.48 1.5 0.645-3.48 1.38 0.783-2.44 1.38 0.783-2.44 1.22 0.787-1.88 1.22 0.787-1.88 1.21 0.89-1.66 1.21 0.89-1.66 1.29 0.859-1.95 0.218 1.21 0.797-1.84 0.372 1.43 0.954-2.14 0.0836 FALSE FALSE FALSE FALSE Both 212 2112 GRCh37/hg19 s=1;Lambda=0.1 2020-06-08 prsweb-phecode151-ukbb-saige-hrc-x151-lassosum-mgi-20200608 prsweb-phecode151-ukbb-saige-hrc-x151-lassosum-mgi-20200608 PRSWEB_PHECODE151_UKBB-SAIGE-HRC-X151_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE151_UKBB-SAIGE-HRC-X151_LASSOSUM_MGI_20200608 151 Cancer of stomach Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative lassosum UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1242 0.26 0.00252739 0.0828 0.525 0.483-0.561 OR 2.01 0.71-5.68 2.01 0.71-5.68 1.98 0.931-4.2 1.98 0.931-4.2 1.69 0.996-2.86 1.69 0.996-2.86 1.22 0.787-1.88 1.22 0.787-1.88 0.953 0.686-1.32 0.953 0.686-1.32 1.22 0.811-1.83 0.343 1.35 0.902-2.01 0.145 1.13 0.747-1.71 0.566 FALSE FALSE FALSE FALSE Both 212 2112 GRCh37/hg19 s=1;Lambda=0.07848 2020-06-08 prsweb-phecode153-20001-1020-p-5e-05-mgi-20200608 prsweb-phecode153-20001-1020-p-5e-05-mgi-20200608 PRSWEB_PHECODE153_20001-1020_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE153_20001-1020_P_5e-05_MGI_20200608 153 Cancer code, self-reported: large bowel cancer/colorectal cancer Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 99 0.46 0.000498831 0.0831 0.505 0.482-0.527 OR 1.38 0.668-2.86 1.38 0.668-2.86 0.855 0.452-1.62 0.855 0.452-1.62 1.03 0.709-1.51 1.03 0.709-1.51 0.904 0.677-1.21 0.904 0.677-1.21 1.01 0.834-1.22 1.01 0.834-1.22 1.29 1.01-1.63 0.0389 1.19 0.937-1.52 0.152 1.16 0.908-1.48 0.236 FALSE FALSE FALSE FALSE Both 607 6026 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode153-crc-huyghe-p-5e-05-mgi-20200608 prsweb-phecode153-crc-huyghe-p-5e-05-mgi-20200608 PRSWEB_PHECODE153_CRC-Huyghe_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE153_CRC-Huyghe_P_5e-05_MGI_20200608 153 Colorectal cancer Binary Supplementary Tables 11 & 15; Cases: Discovery: 34,869; Follow-up: 23,262; Controls: Discovery: 29,051; Follow-up: 38,296 controls MGI Michigan Genomics Initiative Fixed threshold (5e-05) Huyghe JR et al. 2019 30510241 https://www.ncbi.nlm.nih.gov/pubmed/?term=30510241 87 6.9e-06 0.0155196 0.0828 0.552 0.525-0.576 OR 2.39 1.33-4.27 2.39 1.33-4.27 2.48 1.64-3.74 2.48 1.64-3.74 1.61 1.17-2.21 1.61 1.17-2.21 1.47 1.16-1.88 1.47 1.16-1.88 1.54 1.29-1.84 1.54 1.29-1.84 1.06 0.823-1.36 0.662 1.06 0.824-1.36 0.655 1.6 1.27-2.02 6.71e-05 TRUE FALSE FALSE FALSE Both 607 6026 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode153-gwas-catalog-r2019-05-03-x153-p-5e-05-mgi-20200608 prsweb-phecode153-gwas-catalog-r2019-05-03-x153-p-5e-05-mgi-20200608 PRSWEB_PHECODE153_GWAS-Catalog-r2019-05-03-X153_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE153_GWAS-Catalog-r2019-05-03-X153_P_5e-05_MGI_20200608 153 Colorectal cancer Binary 37 unique SNPs MGI Michigan Genomics Initiative Fixed threshold (5e-05) GWAS Catalog (2019-05-03) 17618284;17934461;18372901;19011631;23266556;24737748;25990418;26151821;28960316 https://www.ncbi.nlm.nih.gov/pubmed/?term=17618284+17934461+18372901+19011631+23266556+24737748+25990418+26151821+28960316 27 0.095 0.00481477 0.083 0.516 0.492-0.538 OR 1.89 0.998-3.59 1.89 0.998-3.59 1.46 0.874-2.42 1.46 0.874-2.42 1.05 0.717-1.52 1.05 0.717-1.52 0.909 0.681-1.21 0.909 0.681-1.21 1.1 0.909-1.33 1.1 0.909-1.33 1.29 1.01-1.64 0.0405 1.22 0.952-1.55 0.117 1.28 1-1.63 0.0463 FALSE FALSE FALSE FALSE Both 607 6026 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode153-ukbb-saige-hrc-x153-p-5e-05-mgi-20200608 prsweb-phecode153-ukbb-saige-hrc-x153-p-5e-05-mgi-20200608 PRSWEB_PHECODE153_UKBB-SAIGE-HRC-X153_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE153_UKBB-SAIGE-HRC-X153_P_5e-05_MGI_20200608 153 Colorectal cancer Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 141 0.0034 0.0034341 0.083 0.53 0.506-0.554 OR 1.04 0.459-2.36 1.04 0.459-2.36 1.28 0.747-2.18 1.28 0.747-2.18 1.49 1.08-2.07 1.49 1.08-2.07 1.34 1.04-1.72 1.34 1.04-1.72 1.24 1.03-1.49 1.24 1.03-1.49 1.01 0.791-1.3 0.913 1.17 0.923-1.49 0.193 1.33 1.05-1.68 0.018 TRUE FALSE FALSE FALSE Both 607 6026 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode153-crc-huyghe-p-5e-06-mgi-20200608 prsweb-phecode153-crc-huyghe-p-5e-06-mgi-20200608 PRSWEB_PHECODE153_CRC-Huyghe_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE153_CRC-Huyghe_P_5e-06_MGI_20200608 153 Colorectal cancer Binary Supplementary Tables 11 & 15; Cases: Discovery: 34,869; Follow-up: 23,262; Controls: Discovery: 29,051; Follow-up: 38,296 controls MGI Michigan Genomics Initiative Fixed threshold (5e-06) Huyghe JR et al. 2019 30510241 https://www.ncbi.nlm.nih.gov/pubmed/?term=30510241 85 7e-06 0.0152008 0.0828 0.551 0.525-0.576 OR 2.72 1.56-4.73 2.72 1.56-4.73 2.48 1.64-3.75 2.48 1.64-3.75 1.61 1.17-2.22 1.61 1.17-2.22 1.39 1.09-1.79 1.39 1.09-1.79 1.47 1.23-1.76 1.47 1.23-1.76 1.09 0.848-1.4 0.507 1.11 0.863-1.42 0.424 1.57 1.24-1.98 0.000156 TRUE FALSE FALSE FALSE Both 607 6026 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode153-gwas-catalog-r2019-05-03-x153-p-5e-06-mgi-20200608 prsweb-phecode153-gwas-catalog-r2019-05-03-x153-p-5e-06-mgi-20200608 PRSWEB_PHECODE153_GWAS-Catalog-r2019-05-03-X153_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE153_GWAS-Catalog-r2019-05-03-X153_P_5e-06_MGI_20200608 153 Colorectal cancer Binary 37 unique SNPs MGI Michigan Genomics Initiative Fixed threshold (5e-06) GWAS Catalog (2019-05-03) 17618284;17934461;18372901;19011631;23266556;24737748;25990418;26151821;28960316 https://www.ncbi.nlm.nih.gov/pubmed/?term=17618284+17934461+18372901+19011631+23266556+24737748+25990418+26151821+28960316 26 0.096 0.00472419 0.083 0.515 0.491-0.538 OR 2.05 1.11-3.81 2.05 1.11-3.81 1.45 0.873-2.42 1.45 0.873-2.42 1.01 0.688-1.48 1.01 0.688-1.48 0.909 0.682-1.21 0.909 0.682-1.21 1.09 0.902-1.32 1.09 0.902-1.32 1.3 1.02-1.65 0.0358 1.21 0.951-1.55 0.119 1.27 0.998-1.62 0.0518 FALSE FALSE FALSE FALSE Both 607 6026 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode153-ukbb-saige-hrc-x153-p-5e-06-mgi-20200608 prsweb-phecode153-ukbb-saige-hrc-x153-p-5e-06-mgi-20200608 PRSWEB_PHECODE153_UKBB-SAIGE-HRC-X153_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE153_UKBB-SAIGE-HRC-X153_P_5e-06_MGI_20200608 153 Colorectal cancer Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 30 0.043 0.00560224 0.083 0.518 0.493-0.543 OR 1.55 0.778-3.11 1.55 0.778-3.11 1.45 0.869-2.41 1.45 0.869-2.41 1.46 1.05-2.03 1.46 1.05-2.03 1.22 0.941-1.58 1.22 0.941-1.58 1.14 0.946-1.38 1.14 0.946-1.38 0.88 0.688-1.13 0.309 1.14 0.902-1.44 0.274 1.14 0.907-1.44 0.256 TRUE FALSE FALSE FALSE Both 607 6026 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode153-crc-huyghe-p-5e-07-mgi-20200608 prsweb-phecode153-crc-huyghe-p-5e-07-mgi-20200608 PRSWEB_PHECODE153_CRC-Huyghe_P_5e-07_MGI_20200608 P_5e-07 PRSWEB_PHECODE153_CRC-Huyghe_P_5e-07_MGI_20200608 153 Colorectal cancer Binary Supplementary Tables 11 & 15; Cases: Discovery: 34,869; Follow-up: 23,262; Controls: Discovery: 29,051; Follow-up: 38,296 controls MGI Michigan Genomics Initiative Fixed threshold (5e-07) Huyghe JR et al. 2019 30510241 https://www.ncbi.nlm.nih.gov/pubmed/?term=30510241 81 5.4e-06 0.0156534 0.0828 0.553 0.525-0.577 OR 3.04 1.79-5.17 3.04 1.79-5.17 2.24 1.46-3.44 2.24 1.46-3.44 1.69 1.23-2.31 1.69 1.23-2.31 1.53 1.21-1.95 1.53 1.21-1.95 1.58 1.32-1.89 1.58 1.32-1.89 1.05 0.819-1.35 0.687 1.03 0.803-1.33 0.803 1.63 1.29-2.05 3.39e-05 TRUE FALSE FALSE FALSE Both 607 6026 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode153-gwas-catalog-r2019-05-03-x153-p-5e-07-mgi-20200608 prsweb-phecode153-gwas-catalog-r2019-05-03-x153-p-5e-07-mgi-20200608 PRSWEB_PHECODE153_GWAS-Catalog-r2019-05-03-X153_P_5e-07_MGI_20200608 P_5e-07 PRSWEB_PHECODE153_GWAS-Catalog-r2019-05-03-X153_P_5e-07_MGI_20200608 153 Colorectal cancer Binary 37 unique SNPs MGI Michigan Genomics Initiative Fixed threshold (5e-07) GWAS Catalog (2019-05-03) 17618284;17934461;18372901;19011631;23266556;24737748;25990418;26151821;28960316 https://www.ncbi.nlm.nih.gov/pubmed/?term=17618284+17934461+18372901+19011631+23266556+24737748+25990418+26151821+28960316 22 0.088 0.00468822 0.083 0.515 0.49-0.538 OR 2.04 1.1-3.79 2.04 1.1-3.79 1.37 0.813-2.31 1.37 0.813-2.31 1.04 0.716-1.52 1.04 0.716-1.52 1.15 0.882-1.5 1.15 0.882-1.5 1.1 0.915-1.33 1.1 0.915-1.33 1.04 0.818-1.33 0.734 1.15 0.905-1.45 0.256 1.17 0.926-1.49 0.187 FALSE FALSE FALSE FALSE Both 607 6026 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode153-ukbb-saige-hrc-x153-p-5e-07-mgi-20200608 prsweb-phecode153-ukbb-saige-hrc-x153-p-5e-07-mgi-20200608 PRSWEB_PHECODE153_UKBB-SAIGE-HRC-X153_P_5e-07_MGI_20200608 P_5e-07 PRSWEB_PHECODE153_UKBB-SAIGE-HRC-X153_P_5e-07_MGI_20200608 153 Colorectal cancer Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative Fixed threshold (5e-07) UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 10 0.0062 0.00406733 0.083 0.53 0.504-0.554 OR 1.53 0.764-3.05 1.53 0.764-3.05 1.61 0.991-2.62 1.61 0.991-2.62 1.28 0.904-1.81 1.28 0.904-1.81 1.14 0.875-1.49 1.14 0.875-1.49 1.27 1.06-1.53 1.27 1.06-1.53 1.07 0.834-1.37 0.596 1.21 0.951-1.54 0.121 1.39 1.1-1.76 0.00627 TRUE FALSE FALSE FALSE Both 607 6026 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode153-crc-huyghe-p-5e-09-mgi-20200608 prsweb-phecode153-crc-huyghe-p-5e-09-mgi-20200608 PRSWEB_PHECODE153_CRC-Huyghe_P_5e-09_MGI_20200608 P_5e-09 PRSWEB_PHECODE153_CRC-Huyghe_P_5e-09_MGI_20200608 153 Colorectal cancer Binary Supplementary Tables 11 & 15; Cases: Discovery: 34,869; Follow-up: 23,262; Controls: Discovery: 29,051; Follow-up: 38,296 controls MGI Michigan Genomics Initiative Fixed threshold (5e-09) Huyghe JR et al. 2019 30510241 https://www.ncbi.nlm.nih.gov/pubmed/?term=30510241 56 9.3e-07 0.012687 0.0827 0.559 0.532-0.584 OR 1.89 0.995-3.58 1.89 0.995-3.58 2.41 1.59-3.67 2.41 1.59-3.67 1.8 1.32-2.44 1.8 1.32-2.44 1.49 1.17-1.91 1.49 1.17-1.91 1.47 1.23-1.76 1.47 1.23-1.76 1.02 0.79-1.32 0.878 1.25 0.981-1.6 0.071 1.61 1.27-2.04 6.84e-05 TRUE FALSE FALSE FALSE Both 607 6026 GRCh37/hg19 P<=5e-09 2020-06-08 prsweb-phecode153-gwas-catalog-r2019-05-03-x153-p-5e-09-mgi-20200608 prsweb-phecode153-gwas-catalog-r2019-05-03-x153-p-5e-09-mgi-20200608 PRSWEB_PHECODE153_GWAS-Catalog-r2019-05-03-X153_P_5e-09_MGI_20200608 P_5e-09 PRSWEB_PHECODE153_GWAS-Catalog-r2019-05-03-X153_P_5e-09_MGI_20200608 153 Colorectal cancer Binary 37 unique SNPs MGI Michigan Genomics Initiative Fixed threshold (5e-09) GWAS Catalog (2019-05-03) 17618284;17934461;18372901;19011631;23266556;24737748;25990418;26151821;28960316 https://www.ncbi.nlm.nih.gov/pubmed/?term=17618284+17934461+18372901+19011631+23266556+24737748+25990418+26151821+28960316 12 0.033 0.00326916 0.083 0.521 0.496-0.544 OR 1.39 0.67-2.87 1.39 0.67-2.87 1.36 0.806-2.29 1.36 0.806-2.29 1.18 0.821-1.68 1.18 0.821-1.68 1.27 0.986-1.64 1.27 0.986-1.64 1.27 1.06-1.52 1.27 1.06-1.52 1.07 0.837-1.36 0.598 1.06 0.832-1.36 0.63 1.32 1.05-1.67 0.0188 TRUE FALSE FALSE FALSE Both 607 6026 GRCh37/hg19 P<=5e-09 2020-06-08 prsweb-phecode153-crc-huyghe-p-5e-08-mgi-20200608 prsweb-phecode153-crc-huyghe-p-5e-08-mgi-20200608 PRSWEB_PHECODE153_CRC-Huyghe_P_5e-08_MGI_20200608 P_5e-08 PRSWEB_PHECODE153_CRC-Huyghe_P_5e-08_MGI_20200608 153 Colorectal cancer Binary Supplementary Tables 11 & 15; Cases: Discovery: 34,869; Follow-up: 23,262; Controls: Discovery: 29,051; Follow-up: 38,296 controls MGI Michigan Genomics Initiative GWAS Hits Huyghe JR et al. 2019 30510241 https://www.ncbi.nlm.nih.gov/pubmed/?term=30510241 74 2.1e-05 0.0151591 0.0828 0.55 0.522-0.574 OR 2.2 1.21-4 2.2 1.21-4 2.31 1.51-3.54 2.31 1.51-3.54 1.69 1.24-2.31 1.69 1.24-2.31 1.5 1.18-1.91 1.5 1.18-1.91 1.46 1.22-1.75 1.46 1.22-1.75 0.963 0.746-1.24 0.768 1.18 0.922-1.5 0.192 1.53 1.21-1.93 0.000351 TRUE FALSE FALSE TRUE Both 607 6026 GRCh37/hg19 P<=5e-08 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000367/ScoringFiles/ phewas/PRSWEB_PHECODE153_CRC-Huyghe_P_5e-08_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE153_CRC-Huyghe_P_5e-08_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode153-gwas-catalog-r2019-05-03-x153-p-5e-08-mgi-20200608 prsweb-phecode153-gwas-catalog-r2019-05-03-x153-p-5e-08-mgi-20200608 PRSWEB_PHECODE153_GWAS-Catalog-r2019-05-03-X153_P_5e-08_MGI_20200608 P_5e-08 PRSWEB_PHECODE153_GWAS-Catalog-r2019-05-03-X153_P_5e-08_MGI_20200608 153 Colorectal cancer Binary 37 unique SNPs MGI Michigan Genomics Initiative GWAS Hits GWAS Catalog (2019-05-03) 17618284;17934461;18372901;19011631;23266556;24737748;25990418;26151821;28960316 https://www.ncbi.nlm.nih.gov/pubmed/?term=17618284+17934461+18372901+19011631+23266556+24737748+25990418+26151821+28960316 18 0.058 0.00453584 0.083 0.52 0.495-0.544 OR 1.06 0.467-2.4 1.06 0.467-2.4 0.78 0.4-1.52 0.78 0.4-1.52 1.18 0.824-1.69 1.18 0.824-1.69 1.2 0.924-1.56 1.2 0.924-1.56 1.19 0.99-1.43 1.19 0.99-1.43 1.03 0.803-1.31 0.835 1.2 0.941-1.52 0.143 1.28 1.01-1.62 0.0406 FALSE FALSE FALSE FALSE Both 607 6026 GRCh37/hg19 P<=5e-08 2020-06-08 prsweb-phecode153-20001-1020-pt-mgi-20200608 prsweb-phecode153-20001-1020-pt-mgi-20200608 PRSWEB_PHECODE153_20001-1020_PT_MGI_20200608 P&T PRSWEB_PHECODE153_20001-1020_PT_MGI_20200608 153 Cancer code, self-reported: large bowel cancer/colorectal cancer Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative P&T UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 173 0.077 0.000853913 0.083 0.516 0.493-0.538 OR 1.05 0.464-2.38 1.05 0.464-2.38 1.36 0.805-2.29 1.36 0.805-2.29 1.07 0.735-1.55 1.07 0.735-1.55 1.14 0.876-1.49 1.14 0.876-1.49 1.1 0.914-1.33 1.1 0.914-1.33 1.35 1.06-1.72 0.0136 1.16 0.908-1.49 0.231 1.29 1.01-1.64 0.0416 FALSE FALSE FALSE FALSE Both 607 6026 GRCh37/hg19 P<=9.98e-05 2020-06-08 prsweb-phecode153-crc-huyghe-pt-mgi-20200608 prsweb-phecode153-crc-huyghe-pt-mgi-20200608 PRSWEB_PHECODE153_CRC-Huyghe_PT_MGI_20200608 P&T PRSWEB_PHECODE153_CRC-Huyghe_PT_MGI_20200608 153 Colorectal cancer Binary Supplementary Tables 11 & 15; Cases: Discovery: 34,869; Follow-up: 23,262; Controls: Discovery: 29,051; Follow-up: 38,296 controls MGI Michigan Genomics Initiative P&T Huyghe JR et al. 2019 30510241 https://www.ncbi.nlm.nih.gov/pubmed/?term=30510241 81 5.4e-06 0.0156534 0.0828 0.553 0.525-0.577 OR 3.04 1.79-5.17 3.04 1.79-5.17 2.24 1.46-3.44 2.24 1.46-3.44 1.69 1.23-2.31 1.69 1.23-2.31 1.53 1.21-1.95 1.53 1.21-1.95 1.58 1.32-1.89 1.58 1.32-1.89 1.05 0.819-1.35 0.687 1.03 0.803-1.33 0.803 1.63 1.29-2.05 3.39e-05 TRUE FALSE FALSE TRUE Both 607 6026 GRCh37/hg19 P<=3.98e-07 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000369/ScoringFiles/ phewas/PRSWEB_PHECODE153_CRC-Huyghe_PT_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE153_CRC-Huyghe_PT_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode153-gwas-catalog-r2019-05-03-x153-pt-mgi-20200608 prsweb-phecode153-gwas-catalog-r2019-05-03-x153-pt-mgi-20200608 PRSWEB_PHECODE153_GWAS-Catalog-r2019-05-03-X153_PT_MGI_20200608 P&T PRSWEB_PHECODE153_GWAS-Catalog-r2019-05-03-X153_PT_MGI_20200608 153 Colorectal cancer Binary 37 unique SNPs MGI Michigan Genomics Initiative P&T GWAS Catalog (2019-05-03) 17618284;17934461;18372901;19011631;23266556;24737748;25990418;26151821;28960316 https://www.ncbi.nlm.nih.gov/pubmed/?term=17618284+17934461+18372901+19011631+23266556+24737748+25990418+26151821+28960316 27 0.095 0.00481477 0.083 0.516 0.492-0.538 OR 1.89 0.998-3.59 1.89 0.998-3.59 1.46 0.874-2.42 1.46 0.874-2.42 1.05 0.717-1.52 1.05 0.717-1.52 0.909 0.681-1.21 0.909 0.681-1.21 1.1 0.909-1.33 1.1 0.909-1.33 1.29 1.01-1.64 0.0405 1.22 0.952-1.55 0.117 1.28 1-1.63 0.0463 FALSE FALSE FALSE FALSE Both 607 6026 GRCh37/hg19 P<=7e-06 2020-06-08 prsweb-phecode153-ukbb-saige-hrc-x153-pt-mgi-20200608 prsweb-phecode153-ukbb-saige-hrc-x153-pt-mgi-20200608 PRSWEB_PHECODE153_UKBB-SAIGE-HRC-X153_PT_MGI_20200608 P&T PRSWEB_PHECODE153_UKBB-SAIGE-HRC-X153_PT_MGI_20200608 153 Colorectal cancer Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative P&T UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 41 0.039 0.00630203 0.083 0.517 0.493-0.541 OR 1.88 0.99-3.55 1.88 0.99-3.55 1.6 0.986-2.61 1.6 0.986-2.61 1.53 1.11-2.12 1.53 1.11-2.12 1.39 1.09-1.79 1.39 1.09-1.79 1.08 0.891-1.3 1.08 0.891-1.3 1.2 0.943-1.54 0.137 1.34 1.06-1.71 0.0162 1.27 0.993-1.61 0.0575 TRUE FALSE FALSE TRUE Both 607 6026 GRCh37/hg19 P<=7.94e-06 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000374/ScoringFiles/ phewas/PRSWEB_PHECODE153_UKBB-SAIGE-HRC-X153_PT_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE153_UKBB-SAIGE-HRC-X153_PT_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode153-20001-1020-prs-cs-mgi-20200608 prsweb-phecode153-20001-1020-prs-cs-mgi-20200608 PRSWEB_PHECODE153_20001-1020_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE153_20001-1020_PRS-CS_MGI_20200608 153 Cancer code, self-reported: large bowel cancer/colorectal cancer Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative PRS-CS UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1072047 0.075 0.00091546 0.083 0.523 0.499-0.547 OR 0.717 0.273-1.88 0.717 0.273-1.88 0.855 0.452-1.62 0.855 0.452-1.62 1 0.685-1.47 1 0.685-1.47 1.12 0.854-1.46 1.12 0.854-1.46 1.17 0.969-1.41 1.17 0.969-1.41 1.23 0.961-1.57 0.101 1.24 0.972-1.58 0.0827 1.34 1.06-1.71 0.0164 FALSE FALSE FALSE FALSE Both 607 6026 GRCh37/hg19 auto 2020-06-08 prsweb-phecode153-ukbb-saige-hrc-x153-prs-cs-mgi-20200608 prsweb-phecode153-ukbb-saige-hrc-x153-prs-cs-mgi-20200608 PRSWEB_PHECODE153_UKBB-SAIGE-HRC-X153_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE153_UKBB-SAIGE-HRC-X153_PRS-CS_MGI_20200608 153 Colorectal cancer Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative PRS-CS UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1119238 5.5e-05 0.00596938 0.0829 0.548 0.523-0.572 OR 1.71 0.882-3.33 1.71 0.882-3.33 1.62 0.995-2.64 1.62 0.995-2.64 1.76 1.29-2.39 1.76 1.29-2.39 1.55 1.22-1.97 1.55 1.22-1.97 1.5 1.25-1.79 1.5 1.25-1.79 1.03 0.804-1.32 0.81 1.04 0.815-1.34 0.73 1.51 1.2-1.91 0.000402 TRUE FALSE FALSE TRUE Both 607 6026 GRCh37/hg19 auto https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000373/ScoringFiles/ phewas/PRSWEB_PHECODE153_UKBB-SAIGE-HRC-X153_PRS-CS_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE153_UKBB-SAIGE-HRC-X153_PRS-CS_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode153-ukbb-saige-hrc-x153-lassosum-mgi-20200608 prsweb-phecode153-ukbb-saige-hrc-x153-lassosum-mgi-20200608 PRSWEB_PHECODE153_UKBB-SAIGE-HRC-X153_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE153_UKBB-SAIGE-HRC-X153_LASSOSUM_MGI_20200608 153 Colorectal cancer Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative lassosum UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 370 0.012 0.00380963 0.083 0.53 0.503-0.555 OR 2.76 1.59-4.81 2.76 1.59-4.81 1.91 1.21-3.02 1.91 1.21-3.02 1.57 1.14-2.17 1.57 1.14-2.17 1.27 0.986-1.64 1.27 0.986-1.64 1.3 1.09-1.56 1.3 1.09-1.56 1.01 0.787-1.28 0.965 1.06 0.831-1.35 0.64 1.33 1.06-1.68 0.0152 TRUE FALSE FALSE TRUE Both 607 6026 GRCh37/hg19 s=0.5;Lambda=0.02976 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000375/ScoringFiles/ phewas/PRSWEB_PHECODE153_UKBB-SAIGE-HRC-X153_LASSOSUM_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE153_UKBB-SAIGE-HRC-X153_LASSOSUM_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode153-crc-huyghe-p-5e-05-ukb-20200608 prsweb-phecode153-crc-huyghe-p-5e-05-ukb-20200608 PRSWEB_PHECODE153_CRC-Huyghe_P_5e-05_UKB_20200608 P_5e-05 PRSWEB_PHECODE153_CRC-Huyghe_P_5e-05_UKB_20200608 153 Colorectal cancer Binary Supplementary Tables 11 & 15; Cases: Discovery: 34,869; Follow-up: 23,262; Controls: Discovery: 29,051; Follow-up: 38,296 controls UKB UK Biobank Fixed threshold (5e-05) Huyghe JR et al. 2019 30510241 https://www.ncbi.nlm.nih.gov/pubmed/?term=30510241 87 4.5e-83 0.0336057 0.0812 0.617 0.605-0.63 OR 4 3.11-5.13 4 3.11-5.13 3.4 2.8-4.11 3.4 2.8-4.11 2.69 2.34-3.08 2.69 2.34-3.08 2.35 2.11-2.63 2.35 2.11-2.63 1.99 1.82-2.18 1.99 1.82-2.18 1.34 1.16-1.55 8.6e-05 1.72 1.5-1.98 2.19e-14 2.69 2.36-3.07 3.06e-50 TRUE FALSE FALSE FALSE Both 2271 22725 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode153-gwas-catalog-r2019-05-03-x153-p-5e-05-ukb-20200608 prsweb-phecode153-gwas-catalog-r2019-05-03-x153-p-5e-05-ukb-20200608 PRSWEB_PHECODE153_GWAS-Catalog-r2019-05-03-X153_P_5e-05_UKB_20200608 P_5e-05 PRSWEB_PHECODE153_GWAS-Catalog-r2019-05-03-X153_P_5e-05_UKB_20200608 153 Colorectal cancer Binary 37 unique SNPs UKB UK Biobank Fixed threshold (5e-05) GWAS Catalog (2019-05-03) 17618284;17934461;18372901;19011631;23266556;24737748;25990418;26151821;28960316 https://www.ncbi.nlm.nih.gov/pubmed/?term=17618284+17934461+18372901+19011631+23266556+24737748+25990418+26151821+28960316 27 1.3e-29 0.0134858 0.0822 0.565 0.551-0.577 OR 2.1 1.53-2.89 2.1 1.53-2.89 2.1 1.67-2.63 2.1 1.67-2.63 1.75 1.49-2.05 1.75 1.49-2.05 1.69 1.5-1.91 1.69 1.5-1.91 1.53 1.4-1.68 1.53 1.4-1.68 1.16 1.02-1.33 0.0273 1.33 1.17-1.52 1.5e-05 1.78 1.58-2.02 4.39e-20 TRUE FALSE FALSE FALSE Both 2271 22725 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode153-crc-huyghe-p-5e-06-ukb-20200608 prsweb-phecode153-crc-huyghe-p-5e-06-ukb-20200608 PRSWEB_PHECODE153_CRC-Huyghe_P_5e-06_UKB_20200608 P_5e-06 PRSWEB_PHECODE153_CRC-Huyghe_P_5e-06_UKB_20200608 153 Colorectal cancer Binary Supplementary Tables 11 & 15; Cases: Discovery: 34,869; Follow-up: 23,262; Controls: Discovery: 29,051; Follow-up: 38,296 controls UKB UK Biobank Fixed threshold (5e-06) Huyghe JR et al. 2019 30510241 https://www.ncbi.nlm.nih.gov/pubmed/?term=30510241 85 1.7e-82 0.0334415 0.0812 0.617 0.605-0.63 OR 3.85 2.99-4.96 3.85 2.99-4.96 3.44 2.85-4.17 3.44 2.85-4.17 2.69 2.34-3.08 2.69 2.34-3.08 2.31 2.07-2.58 2.31 2.07-2.58 2 1.83-2.18 2 1.83-2.18 1.36 1.18-1.58 3.81e-05 1.79 1.55-2.05 4.19e-16 2.75 2.41-3.14 1.15e-51 TRUE FALSE FALSE FALSE Both 2271 22725 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode153-gwas-catalog-r2019-05-03-x153-p-5e-06-ukb-20200608 prsweb-phecode153-gwas-catalog-r2019-05-03-x153-p-5e-06-ukb-20200608 PRSWEB_PHECODE153_GWAS-Catalog-r2019-05-03-X153_P_5e-06_UKB_20200608 P_5e-06 PRSWEB_PHECODE153_GWAS-Catalog-r2019-05-03-X153_P_5e-06_UKB_20200608 153 Colorectal cancer Binary 37 unique SNPs UKB UK Biobank Fixed threshold (5e-06) GWAS Catalog (2019-05-03) 17618284;17934461;18372901;19011631;23266556;24737748;25990418;26151821;28960316 https://www.ncbi.nlm.nih.gov/pubmed/?term=17618284+17934461+18372901+19011631+23266556+24737748+25990418+26151821+28960316 26 3.1e-29 0.0133918 0.0822 0.564 0.551-0.577 OR 2.1 1.53-2.89 2.1 1.53-2.89 2.05 1.63-2.58 2.05 1.63-2.58 1.78 1.52-2.08 1.78 1.52-2.08 1.69 1.49-1.9 1.69 1.49-1.9 1.53 1.4-1.68 1.53 1.4-1.68 1.17 1.02-1.34 0.0211 1.35 1.18-1.54 6.56e-06 1.8 1.59-2.03 1.95e-20 TRUE FALSE FALSE FALSE Both 2271 22725 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode153-crc-huyghe-p-5e-07-ukb-20200608 prsweb-phecode153-crc-huyghe-p-5e-07-ukb-20200608 PRSWEB_PHECODE153_CRC-Huyghe_P_5e-07_UKB_20200608 P_5e-07 PRSWEB_PHECODE153_CRC-Huyghe_P_5e-07_UKB_20200608 153 Colorectal cancer Binary Supplementary Tables 11 & 15; Cases: Discovery: 34,869; Follow-up: 23,262; Controls: Discovery: 29,051; Follow-up: 38,296 controls UKB UK Biobank Fixed threshold (5e-07) Huyghe JR et al. 2019 30510241 https://www.ncbi.nlm.nih.gov/pubmed/?term=30510241 81 6.6e-81 0.0330113 0.0812 0.616 0.604-0.629 OR 3.85 2.99-4.96 3.85 2.99-4.96 3.3 2.72-4 3.3 2.72-4 2.66 2.32-3.06 2.66 2.32-3.06 2.36 2.11-2.63 2.36 2.11-2.63 2.03 1.86-2.22 2.03 1.86-2.22 1.32 1.14-1.53 0.000253 1.78 1.54-2.04 7.02e-16 2.76 2.43-3.15 2.1e-52 TRUE FALSE FALSE FALSE Both 2271 22725 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode153-gwas-catalog-r2019-05-03-x153-p-5e-07-ukb-20200608 prsweb-phecode153-gwas-catalog-r2019-05-03-x153-p-5e-07-ukb-20200608 PRSWEB_PHECODE153_GWAS-Catalog-r2019-05-03-X153_P_5e-07_UKB_20200608 P_5e-07 PRSWEB_PHECODE153_GWAS-Catalog-r2019-05-03-X153_P_5e-07_UKB_20200608 153 Colorectal cancer Binary 37 unique SNPs UKB UK Biobank Fixed threshold (5e-07) GWAS Catalog (2019-05-03) 17618284;17934461;18372901;19011631;23266556;24737748;25990418;26151821;28960316 https://www.ncbi.nlm.nih.gov/pubmed/?term=17618284+17934461+18372901+19011631+23266556+24737748+25990418+26151821+28960316 22 8.7e-26 0.0118471 0.0822 0.561 0.548-0.573 OR 1.65 1.17-2.34 1.65 1.17-2.34 1.94 1.53-2.45 1.94 1.53-2.45 1.6 1.36-1.89 1.6 1.36-1.89 1.69 1.49-1.9 1.69 1.49-1.9 1.49 1.36-1.63 1.49 1.36-1.63 1.19 1.04-1.36 0.0113 1.36 1.19-1.55 4.08e-06 1.75 1.55-1.99 6.71e-19 TRUE FALSE FALSE FALSE Both 2271 22725 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode153-crc-huyghe-p-5e-09-ukb-20200608 prsweb-phecode153-crc-huyghe-p-5e-09-ukb-20200608 PRSWEB_PHECODE153_CRC-Huyghe_P_5e-09_UKB_20200608 P_5e-09 PRSWEB_PHECODE153_CRC-Huyghe_P_5e-09_UKB_20200608 153 Colorectal cancer Binary Supplementary Tables 11 & 15; Cases: Discovery: 34,869; Follow-up: 23,262; Controls: Discovery: 29,051; Follow-up: 38,296 controls UKB UK Biobank Fixed threshold (5e-09) Huyghe JR et al. 2019 30510241 https://www.ncbi.nlm.nih.gov/pubmed/?term=30510241 56 4.8e-69 0.0274185 0.0814 0.607 0.594-0.62 OR 3.39 2.6-4.41 3.39 2.6-4.41 2.86 2.33-3.5 2.86 2.33-3.5 2.55 2.22-2.94 2.55 2.22-2.94 2.21 1.97-2.47 2.21 1.97-2.47 1.9 1.74-2.08 1.9 1.74-2.08 1.48 1.28-1.71 8.54e-08 1.74 1.51-2.01 8.43e-15 2.67 2.34-3.05 1.73e-48 TRUE FALSE FALSE FALSE Both 2271 22725 GRCh37/hg19 P<=5e-09 2020-06-08 prsweb-phecode153-gwas-catalog-r2019-05-03-x153-p-5e-09-ukb-20200608 prsweb-phecode153-gwas-catalog-r2019-05-03-x153-p-5e-09-ukb-20200608 PRSWEB_PHECODE153_GWAS-Catalog-r2019-05-03-X153_P_5e-09_UKB_20200608 P_5e-09 PRSWEB_PHECODE153_GWAS-Catalog-r2019-05-03-X153_P_5e-09_UKB_20200608 153 Colorectal cancer Binary 37 unique SNPs UKB UK Biobank Fixed threshold (5e-09) GWAS Catalog (2019-05-03) 17618284;17934461;18372901;19011631;23266556;24737748;25990418;26151821;28960316 https://www.ncbi.nlm.nih.gov/pubmed/?term=17618284+17934461+18372901+19011631+23266556+24737748+25990418+26151821+28960316 12 9.7e-25 0.0111996 0.0822 0.56 0.547-0.572 OR 1.79 1.28-2.51 1.79 1.28-2.51 1.73 1.35-2.21 1.73 1.35-2.21 1.64 1.39-1.93 1.64 1.39-1.93 1.67 1.48-1.89 1.67 1.48-1.89 1.48 1.35-1.63 1.48 1.35-1.63 1.24 1.08-1.41 0.00174 1.36 1.2-1.55 3.47e-06 1.78 1.57-2.02 1.09e-19 TRUE FALSE FALSE FALSE Both 2271 22725 GRCh37/hg19 P<=5e-09 2020-06-08 prsweb-phecode153-crc-huyghe-p-5e-08-ukb-20200608 prsweb-phecode153-crc-huyghe-p-5e-08-ukb-20200608 PRSWEB_PHECODE153_CRC-Huyghe_P_5e-08_UKB_20200608 P_5e-08 PRSWEB_PHECODE153_CRC-Huyghe_P_5e-08_UKB_20200608 153 Colorectal cancer Binary Supplementary Tables 11 & 15; Cases: Discovery: 34,869; Follow-up: 23,262; Controls: Discovery: 29,051; Follow-up: 38,296 controls UKB UK Biobank GWAS Hits Huyghe JR et al. 2019 30510241 https://www.ncbi.nlm.nih.gov/pubmed/?term=30510241 74 3.6e-76 0.0310016 0.0813 0.612 0.6-0.625 OR 3.85 2.99-4.96 3.85 2.99-4.96 3.17 2.61-3.86 3.17 2.61-3.86 2.71 2.36-3.11 2.71 2.36-3.11 2.29 2.05-2.56 2.29 2.05-2.56 1.98 1.81-2.17 1.98 1.81-2.17 1.3 1.12-1.5 0.000434 1.7 1.48-1.95 7.25e-14 2.64 2.32-3.01 7.83e-49 TRUE FALSE FALSE TRUE Both 2271 22725 GRCh37/hg19 P<=5e-08 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000368/ScoringFiles/ phewas/PRSWEB_PHECODE153_CRC-Huyghe_P_5e-08_UKB_20200608/all.tsv phewas/PRSWEB_PHECODE153_CRC-Huyghe_P_5e-08_UKB_20200608/exclusion.tsv 2020-06-08 prsweb-phecode153-gwas-catalog-r2019-05-03-x153-p-5e-08-ukb-20200608 prsweb-phecode153-gwas-catalog-r2019-05-03-x153-p-5e-08-ukb-20200608 PRSWEB_PHECODE153_GWAS-Catalog-r2019-05-03-X153_P_5e-08_UKB_20200608 P_5e-08 PRSWEB_PHECODE153_GWAS-Catalog-r2019-05-03-X153_P_5e-08_UKB_20200608 153 Colorectal cancer Binary 37 unique SNPs UKB UK Biobank GWAS Hits GWAS Catalog (2019-05-03) 17618284;17934461;18372901;19011631;23266556;24737748;25990418;26151821;28960316 https://www.ncbi.nlm.nih.gov/pubmed/?term=17618284+17934461+18372901+19011631+23266556+24737748+25990418+26151821+28960316 18 1.9e-25 0.0116021 0.0822 0.561 0.548-0.573 OR 1.79 1.28-2.51 1.79 1.28-2.51 1.77 1.39-2.26 1.77 1.39-2.26 1.64 1.39-1.93 1.64 1.39-1.93 1.59 1.4-1.79 1.59 1.4-1.79 1.49 1.35-1.63 1.49 1.35-1.63 1.13 0.992-1.3 0.0664 1.36 1.19-1.54 3.39e-06 1.72 1.52-1.95 5.31e-18 TRUE FALSE FALSE TRUE Both 2271 22725 GRCh37/hg19 P<=5e-08 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000371/ScoringFiles/ phewas/PRSWEB_PHECODE153_GWAS-Catalog-r2019-05-03-X153_P_5e-08_UKB_20200608/all.tsv phewas/PRSWEB_PHECODE153_GWAS-Catalog-r2019-05-03-X153_P_5e-08_UKB_20200608/exclusion.tsv 2020-06-08 prsweb-phecode153-crc-huyghe-pt-ukb-20200608 prsweb-phecode153-crc-huyghe-pt-ukb-20200608 PRSWEB_PHECODE153_CRC-Huyghe_PT_UKB_20200608 P&T PRSWEB_PHECODE153_CRC-Huyghe_PT_UKB_20200608 153 Colorectal cancer Binary Supplementary Tables 11 & 15; Cases: Discovery: 34,869; Follow-up: 23,262; Controls: Discovery: 29,051; Follow-up: 38,296 controls UKB UK Biobank P&T Huyghe JR et al. 2019 30510241 https://www.ncbi.nlm.nih.gov/pubmed/?term=30510241 87 4.5e-83 0.0336057 0.0812 0.617 0.605-0.63 OR 4 3.11-5.13 4 3.11-5.13 3.4 2.8-4.11 3.4 2.8-4.11 2.69 2.34-3.08 2.69 2.34-3.08 2.35 2.11-2.63 2.35 2.11-2.63 1.99 1.82-2.18 1.99 1.82-2.18 1.34 1.16-1.55 8.6e-05 1.72 1.5-1.98 2.19e-14 2.69 2.36-3.07 3.06e-50 TRUE FALSE FALSE TRUE Both 2271 22725 GRCh37/hg19 P<=7.8e-06 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000370/ScoringFiles/ phewas/PRSWEB_PHECODE153_CRC-Huyghe_PT_UKB_20200608/all.tsv phewas/PRSWEB_PHECODE153_CRC-Huyghe_PT_UKB_20200608/exclusion.tsv 2020-06-08 prsweb-phecode153-gwas-catalog-r2019-05-03-x153-pt-ukb-20200608 prsweb-phecode153-gwas-catalog-r2019-05-03-x153-pt-ukb-20200608 PRSWEB_PHECODE153_GWAS-Catalog-r2019-05-03-X153_PT_UKB_20200608 P&T PRSWEB_PHECODE153_GWAS-Catalog-r2019-05-03-X153_PT_UKB_20200608 153 Colorectal cancer Binary 37 unique SNPs UKB UK Biobank P&T GWAS Catalog (2019-05-03) 17618284;17934461;18372901;19011631;23266556;24737748;25990418;26151821;28960316 https://www.ncbi.nlm.nih.gov/pubmed/?term=17618284+17934461+18372901+19011631+23266556+24737748+25990418+26151821+28960316 27 1.3e-29 0.0134858 0.0822 0.565 0.551-0.577 OR 2.1 1.53-2.89 2.1 1.53-2.89 2.1 1.67-2.63 2.1 1.67-2.63 1.75 1.49-2.05 1.75 1.49-2.05 1.69 1.5-1.91 1.69 1.5-1.91 1.53 1.4-1.68 1.53 1.4-1.68 1.16 1.02-1.33 0.0273 1.33 1.17-1.52 1.5e-05 1.78 1.58-2.02 4.39e-20 TRUE FALSE FALSE TRUE Both 2271 22725 GRCh37/hg19 P<=7e-06 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000372/ScoringFiles/ phewas/PRSWEB_PHECODE153_GWAS-Catalog-r2019-05-03-X153_PT_UKB_20200608/all.tsv phewas/PRSWEB_PHECODE153_GWAS-Catalog-r2019-05-03-X153_PT_UKB_20200608/exclusion.tsv 2020-06-08 prsweb-phecode153-2-20001-1022-p-5e-05-mgi-20200608 prsweb-phecode153-2-20001-1022-p-5e-05-mgi-20200608 PRSWEB_PHECODE153.2_20001-1022_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE153.2_20001-1022_P_5e-05_MGI_20200608 153.2 Cancer code, self-reported: colon cancer/sigmoid cancer Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 138 0.87 0.000122396 0.0833 0.496 0.47-0.525 OR 0.729 0.243-2.19 0.729 0.243-2.19 1.22 0.654-2.27 1.22 0.654-2.27 1.01 0.652-1.56 1.01 0.652-1.56 1 0.73-1.38 1 0.73-1.38 1.15 0.932-1.43 1.15 0.932-1.43 1.2 0.917-1.57 0.185 0.889 0.669-1.18 0.421 1.19 0.909-1.55 0.208 FALSE FALSE FALSE FALSE Both 462 4569 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode153-2-c18-p-5e-05-mgi-20200608 prsweb-phecode153-2-c18-p-5e-05-mgi-20200608 PRSWEB_PHECODE153.2_C18_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE153.2_C18_P_5e-05_MGI_20200608 153.2 Diagnoses - main ICD10: C18 Malignant neoplasm of colon Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 144 0.99 7.23153e-06 0.0833 0.497 0.47-0.525 OR 1.61 0.736-3.53 1.61 0.736-3.53 1.14 0.594-2.17 1.14 0.594-2.17 0.839 0.523-1.35 0.839 0.523-1.35 0.914 0.657-1.27 0.914 0.657-1.27 0.886 0.706-1.11 0.886 0.706-1.11 1.1 0.844-1.45 0.47 1.14 0.876-1.5 0.324 0.956 0.724-1.26 0.753 FALSE FALSE FALSE FALSE Both 462 4569 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode153-2-c3-colon-p-5e-05-mgi-20200608 prsweb-phecode153-2-c3-colon-p-5e-05-mgi-20200608 PRSWEB_PHECODE153.2_C3-COLON_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE153.2_C3-COLON_P_5e-05_MGI_20200608 153.2 Malignant neoplasm of colon Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 136 0.74 0.000680449 0.0833 0.507 0.481-0.536 OR 0.313 0.0606-1.61 0.313 0.0606-1.61 0.582 0.245-1.39 0.582 0.245-1.39 0.924 0.588-1.45 0.924 0.588-1.45 1.12 0.827-1.52 1.12 0.827-1.52 1.08 0.868-1.34 1.08 0.868-1.34 1 0.761-1.32 0.982 1.11 0.851-1.46 0.432 1.11 0.85-1.46 0.433 FALSE FALSE FALSE FALSE Both 462 4569 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode153-2-ukbb-saige-hrc-x153-2-p-5e-05-mgi-20200608 prsweb-phecode153-2-ukbb-saige-hrc-x153-2-p-5e-05-mgi-20200608 PRSWEB_PHECODE153.2_UKBB-SAIGE-HRC-X153.2_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE153.2_UKBB-SAIGE-HRC-X153.2_P_5e-05_MGI_20200608 153.2 Colon cancer Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 127 0.0044 4.87739e-05 0.0832 0.536 0.509-0.565 OR 0.729 0.243-2.19 0.729 0.243-2.19 1.45 0.808-2.59 1.45 0.808-2.59 1.42 0.973-2.09 1.42 0.973-2.09 1.4 1.05-1.85 1.4 1.05-1.85 1.16 0.936-1.44 1.16 0.936-1.44 1.24 0.934-1.64 0.138 1.32 1-1.75 0.049 1.39 1.05-1.84 0.0198 TRUE FALSE FALSE FALSE Both 462 4569 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode153-2-20001-1022-p-5e-06-mgi-20200608 prsweb-phecode153-2-20001-1022-p-5e-06-mgi-20200608 PRSWEB_PHECODE153.2_20001-1022_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE153.2_20001-1022_P_5e-06_MGI_20200608 153.2 Cancer code, self-reported: colon cancer/sigmoid cancer Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 18 0.85 0.00025859 0.0833 0.486 0.46-0.512 OR 0.514 0.142-1.86 0.514 0.142-1.86 0.904 0.444-1.84 0.904 0.444-1.84 0.875 0.551-1.39 0.875 0.551-1.39 0.983 0.713-1.35 0.983 0.713-1.35 1.01 0.809-1.26 1.01 0.809-1.26 0.893 0.677-1.18 0.424 1.13 0.869-1.47 0.36 1.02 0.777-1.33 0.895 FALSE FALSE FALSE FALSE Both 462 4569 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode153-2-c18-p-5e-06-mgi-20200608 prsweb-phecode153-2-c18-p-5e-06-mgi-20200608 PRSWEB_PHECODE153.2_C18_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE153.2_C18_P_5e-06_MGI_20200608 153.2 Diagnoses - main ICD10: C18 Malignant neoplasm of colon Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 24 0.49 0.000487952 0.0833 0.5 0.473-0.527 OR 0.966 0.362-2.58 0.966 0.362-2.58 1.25 0.669-2.33 1.25 0.669-2.33 1.15 0.76-1.74 1.15 0.76-1.74 1.05 0.769-1.44 1.05 0.769-1.44 1.1 0.89-1.37 1.1 0.89-1.37 1.01 0.769-1.32 0.964 0.932 0.709-1.23 0.617 1.08 0.825-1.4 0.591 FALSE FALSE FALSE FALSE Both 462 4569 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode153-2-c3-colon-p-5e-06-mgi-20200608 prsweb-phecode153-2-c3-colon-p-5e-06-mgi-20200608 PRSWEB_PHECODE153.2_C3-COLON_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE153.2_C3-COLON_P_5e-06_MGI_20200608 153.2 Malignant neoplasm of colon Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 25 0.11 0.000194416 0.0833 0.508 0.481-0.536 OR 1.16 0.473-2.84 1.16 0.473-2.84 1.11 0.582-2.13 1.11 0.582-2.13 1.09 0.719-1.67 1.09 0.719-1.67 1.3 0.972-1.74 1.3 0.972-1.74 1.06 0.855-1.32 1.06 0.855-1.32 1.06 0.802-1.39 0.695 1.14 0.871-1.5 0.334 1.12 0.856-1.47 0.402 FALSE FALSE FALSE FALSE Both 462 4569 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode153-2-ukbb-saige-hrc-x153-2-p-5e-06-mgi-20200608 prsweb-phecode153-2-ukbb-saige-hrc-x153-2-p-5e-06-mgi-20200608 PRSWEB_PHECODE153.2_UKBB-SAIGE-HRC-X153.2_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE153.2_UKBB-SAIGE-HRC-X153.2_P_5e-06_MGI_20200608 153.2 Colon cancer Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 20 2.4e-06 0.0012952 0.083 0.559 0.532-0.586 OR 1.6 0.733-3.51 1.6 0.733-3.51 1.11 0.581-2.12 1.11 0.581-2.12 1.28 0.863-1.91 1.28 0.863-1.91 1.38 1.03-1.83 1.38 1.03-1.83 1.42 1.16-1.75 1.42 1.16-1.75 1.17 0.868-1.59 0.298 1.56 1.17-2.07 0.00235 1.79 1.35-2.36 4.81e-05 TRUE FALSE FALSE FALSE Both 462 4569 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode153-2-20001-1022-pt-mgi-20200608 prsweb-phecode153-2-20001-1022-pt-mgi-20200608 PRSWEB_PHECODE153.2_20001-1022_PT_MGI_20200608 P&T PRSWEB_PHECODE153.2_20001-1022_PT_MGI_20200608 153.2 Cancer code, self-reported: colon cancer/sigmoid cancer Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative P&T UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 11 0.52 0.00105527 0.0833 0.492 0.467-0.521 OR 0.73 0.243-2.19 0.73 0.243-2.19 1 0.508-1.97 1 0.508-1.97 0.926 0.589-1.46 0.926 0.589-1.46 1.13 0.835-1.54 1.13 0.835-1.54 1.12 0.899-1.38 1.12 0.899-1.38 0.982 0.747-1.29 0.896 1.01 0.771-1.33 0.929 1.11 0.852-1.45 0.432 FALSE FALSE FALSE FALSE Both 462 4569 GRCh37/hg19 P<=3.16e-06 2020-06-08 prsweb-phecode153-2-c18-pt-mgi-20200608 prsweb-phecode153-2-c18-pt-mgi-20200608 PRSWEB_PHECODE153.2_C18_PT_MGI_20200608 P&T PRSWEB_PHECODE153.2_C18_PT_MGI_20200608 153.2 Diagnoses - main ICD10: C18 Malignant neoplasm of colon Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative P&T UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 5 0.11 0.00219917 0.0833 0.508 0.482-0.535 OR 1.16 0.475-2.85 1.16 0.475-2.85 0.791 0.373-1.68 0.791 0.373-1.68 1.05 0.687-1.62 1.05 0.687-1.62 1.12 0.828-1.53 1.12 0.828-1.53 1.18 0.951-1.46 1.18 0.951-1.46 1.2 0.905-1.59 0.207 1.22 0.924-1.61 0.159 1.34 1.02-1.76 0.0362 FALSE FALSE FALSE FALSE Both 462 4569 GRCh37/hg19 P<=6.31e-07 2020-06-08 prsweb-phecode153-2-c3-colon-pt-mgi-20200608 prsweb-phecode153-2-c3-colon-pt-mgi-20200608 PRSWEB_PHECODE153.2_C3-COLON_PT_MGI_20200608 P&T PRSWEB_PHECODE153.2_C3-COLON_PT_MGI_20200608 153.2 Malignant neoplasm of colon Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative P&T UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 18 0.1 0.00164706 0.0833 0.513 0.485-0.541 OR 1.18 0.482-2.9 1.18 0.482-2.9 1.24 0.667-2.31 1.24 0.667-2.31 1.19 0.794-1.8 1.19 0.794-1.8 1.05 0.769-1.44 1.05 0.769-1.44 1.13 0.908-1.39 1.13 0.908-1.39 1.17 0.883-1.55 0.272 1.33 1.01-1.75 0.0415 1.29 0.981-1.71 0.0684 FALSE FALSE FALSE FALSE Both 462 4569 GRCh37/hg19 P<=2.51e-06 2020-06-08 prsweb-phecode153-2-ukbb-saige-hrc-x153-2-pt-mgi-20200608 prsweb-phecode153-2-ukbb-saige-hrc-x153-2-pt-mgi-20200608 PRSWEB_PHECODE153.2_UKBB-SAIGE-HRC-X153.2_PT_MGI_20200608 P&T PRSWEB_PHECODE153.2_UKBB-SAIGE-HRC-X153.2_PT_MGI_20200608 153.2 Colon cancer Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative P&T UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 12 4.4e-05 0.00314441 0.0831 0.55 0.522-0.577 OR 1.6 0.733-3.51 1.6 0.733-3.51 1.68 0.971-2.91 1.68 0.971-2.91 1.28 0.863-1.9 1.28 0.863-1.9 1.29 0.966-1.73 1.29 0.966-1.73 1.5 1.22-1.84 1.5 1.22-1.84 1.28 0.951-1.71 0.105 1.38 1.04-1.85 0.0279 1.83 1.39-2.42 1.85e-05 TRUE FALSE FALSE TRUE Both 462 4569 GRCh37/hg19 P<=2e-06 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000381/ScoringFiles/ phewas/PRSWEB_PHECODE153.2_UKBB-SAIGE-HRC-X153.2_PT_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE153.2_UKBB-SAIGE-HRC-X153.2_PT_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode153-2-20001-1022-prs-cs-mgi-20200608 prsweb-phecode153-2-20001-1022-prs-cs-mgi-20200608 PRSWEB_PHECODE153.2_20001-1022_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE153.2_20001-1022_PRS-CS_MGI_20200608 153.2 Cancer code, self-reported: colon cancer/sigmoid cancer Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative PRS-CS UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1104674 0.074 0.00159419 0.0833 0.517 0.489-0.544 OR 2.7 1.43-5.11 2.7 1.43-5.11 2.23 1.37-3.65 2.23 1.37-3.65 1.48 1.02-2.15 1.48 1.02-2.15 1.14 0.846-1.55 1.14 0.846-1.55 1.09 0.88-1.36 1.09 0.88-1.36 1.1 0.84-1.45 0.479 1.03 0.785-1.36 0.813 1.14 0.87-1.49 0.341 FALSE FALSE FALSE FALSE Both 462 4569 GRCh37/hg19 auto 2020-06-08 prsweb-phecode153-2-c18-prs-cs-mgi-20200608 prsweb-phecode153-2-c18-prs-cs-mgi-20200608 PRSWEB_PHECODE153.2_C18_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE153.2_C18_PRS-CS_MGI_20200608 153.2 Diagnoses - main ICD10: C18 Malignant neoplasm of colon Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative PRS-CS UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1111490 0.00089 0.00299079 0.0832 0.547 0.518-0.576 OR 1.65 0.753-3.61 1.65 0.753-3.61 1.36 0.746-2.48 1.36 0.746-2.48 1.53 1.05-2.22 1.53 1.05-2.22 1.43 1.08-1.89 1.43 1.08-1.89 1.23 0.999-1.52 1.23 0.999-1.52 1.26 0.946-1.69 0.114 1.42 1.07-1.89 0.0137 1.53 1.15-2.02 0.00302 TRUE FALSE FALSE TRUE Both 462 4569 GRCh37/hg19 auto https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000376/ScoringFiles/ phewas/PRSWEB_PHECODE153.2_C18_PRS-CS_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE153.2_C18_PRS-CS_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode153-2-c3-colon-prs-cs-mgi-20200608 prsweb-phecode153-2-c3-colon-prs-cs-mgi-20200608 PRSWEB_PHECODE153.2_C3-COLON_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE153.2_C3-COLON_PRS-CS_MGI_20200608 153.2 Malignant neoplasm of colon Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative PRS-CS UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1111399 0.0065 0.00373392 0.0832 0.536 0.509-0.565 OR 1.82 0.867-3.84 1.82 0.867-3.84 1.92 1.14-3.24 1.92 1.14-3.24 1.64 1.14-2.35 1.64 1.14-2.35 1.16 0.855-1.57 1.16 0.855-1.57 1.2 0.967-1.48 1.2 0.967-1.48 1.45 1.09-1.93 0.011 1.41 1.06-1.88 0.019 1.54 1.16-2.04 0.00282 TRUE FALSE FALSE TRUE Both 462 4569 GRCh37/hg19 auto https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000378/ScoringFiles/ phewas/PRSWEB_PHECODE153.2_C3-COLON_PRS-CS_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE153.2_C3-COLON_PRS-CS_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode153-2-ukbb-saige-hrc-x153-2-prs-cs-mgi-20200608 prsweb-phecode153-2-ukbb-saige-hrc-x153-2-prs-cs-mgi-20200608 PRSWEB_PHECODE153.2_UKBB-SAIGE-HRC-X153.2_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE153.2_UKBB-SAIGE-HRC-X153.2_PRS-CS_MGI_20200608 153.2 Colon cancer Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative PRS-CS UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1119238 9.8e-09 0.00231342 0.0827 0.569 0.539-0.599 OR 3.85 2.19-6.77 3.85 2.19-6.77 3.32 2.16-5.09 3.32 2.16-5.09 2.42 1.76-3.32 2.42 1.76-3.32 1.84 1.42-2.4 1.84 1.42-2.4 1.42 1.16-1.75 1.42 1.16-1.75 1.4 1.04-1.88 0.0281 1.6 1.19-2.14 0.00169 1.94 1.46-2.58 5.89e-06 TRUE FALSE FALSE TRUE Both 462 4569 GRCh37/hg19 auto https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000380/ScoringFiles/ phewas/PRSWEB_PHECODE153.2_UKBB-SAIGE-HRC-X153.2_PRS-CS_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE153.2_UKBB-SAIGE-HRC-X153.2_PRS-CS_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode153-2-20001-1022-lassosum-mgi-20200608 prsweb-phecode153-2-20001-1022-lassosum-mgi-20200608 PRSWEB_PHECODE153.2_20001-1022_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE153.2_20001-1022_LASSOSUM_MGI_20200608 153.2 Cancer code, self-reported: colon cancer/sigmoid cancer Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative lassosum UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 5818307 0.37 0.000882096 0.0833 0.513 0.485-0.538 OR 0.948 0.356-2.53 0.948 0.356-2.53 1.13 0.591-2.16 1.13 0.591-2.16 1.11 0.727-1.69 1.11 0.727-1.69 0.889 0.637-1.24 0.889 0.637-1.24 1.07 0.859-1.33 1.07 0.859-1.33 1.1 0.835-1.46 0.488 1.24 0.941-1.63 0.127 1.19 0.906-1.57 0.21 FALSE FALSE FALSE FALSE Both 462 4569 GRCh37/hg19 s=1;Lambda=0.001 2020-06-08 prsweb-phecode153-2-c18-lassosum-mgi-20200608 prsweb-phecode153-2-c18-lassosum-mgi-20200608 PRSWEB_PHECODE153.2_C18_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE153.2_C18_LASSOSUM_MGI_20200608 153.2 Diagnoses - main ICD10: C18 Malignant neoplasm of colon Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative lassosum UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 5740814 0.0011 0.00245316 0.0831 0.545 0.518-0.574 OR 1.4 0.607-3.22 1.4 0.607-3.22 1.37 0.751-2.5 1.37 0.751-2.5 1.53 1.06-2.23 1.53 1.06-2.23 1.6 1.22-2.1 1.6 1.22-2.1 1.45 1.18-1.78 1.45 1.18-1.78 0.877 0.656-1.17 0.378 1.1 0.839-1.45 0.48 1.43 1.1-1.86 0.00702 TRUE FALSE FALSE TRUE Both 462 4569 GRCh37/hg19 s=1;Lambda=0.001 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000377/ScoringFiles/ phewas/PRSWEB_PHECODE153.2_C18_LASSOSUM_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE153.2_C18_LASSOSUM_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode153-2-c3-colon-lassosum-mgi-20200608 prsweb-phecode153-2-c3-colon-lassosum-mgi-20200608 PRSWEB_PHECODE153.2_C3-COLON_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE153.2_C3-COLON_LASSOSUM_MGI_20200608 153.2 Malignant neoplasm of colon Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative lassosum UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 5715093 0.0064 0.00263802 0.0832 0.536 0.51-0.567 OR 0.757 0.252-2.28 0.757 0.252-2.28 1.04 0.53-2.06 1.04 0.53-2.06 1.55 1.07-2.25 1.55 1.07-2.25 1.39 1.04-1.84 1.39 1.04-1.84 1.38 1.12-1.7 1.38 1.12-1.7 1.1 0.833-1.46 0.496 1.02 0.766-1.35 0.906 1.45 1.11-1.89 0.00607 TRUE FALSE FALSE TRUE Both 462 4569 GRCh37/hg19 s=1;Lambda=0.001 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000379/ScoringFiles/ phewas/PRSWEB_PHECODE153.2_C3-COLON_LASSOSUM_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE153.2_C3-COLON_LASSOSUM_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode153-2-ukbb-saige-hrc-x153-2-lassosum-mgi-20200608 prsweb-phecode153-2-ukbb-saige-hrc-x153-2-lassosum-mgi-20200608 PRSWEB_PHECODE153.2_UKBB-SAIGE-HRC-X153.2_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE153.2_UKBB-SAIGE-HRC-X153.2_LASSOSUM_MGI_20200608 153.2 Colon cancer Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative lassosum UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 150 4.9e-06 0.00231173 0.083 0.567 0.54-0.594 OR 1.17 0.477-2.87 1.17 0.477-2.87 1.12 0.587-2.15 1.12 0.587-2.15 1.47 1.01-2.14 1.47 1.01-2.14 1.46 1.1-1.93 1.46 1.1-1.93 1.55 1.26-1.9 1.55 1.26-1.9 1.34 0.989-1.81 0.059 1.55 1.16-2.08 0.00349 2 1.51-2.66 1.34e-06 TRUE FALSE FALSE TRUE Both 462 4569 GRCh37/hg19 s=0.2;Lambda=0.03793 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000382/ScoringFiles/ phewas/PRSWEB_PHECODE153.2_UKBB-SAIGE-HRC-X153.2_LASSOSUM_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE153.2_UKBB-SAIGE-HRC-X153.2_LASSOSUM_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode153-3-c19-p-5e-05-mgi-20200608 prsweb-phecode153-3-c19-p-5e-05-mgi-20200608 PRSWEB_PHECODE153.3_C19_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE153.3_C19_P_5e-05_MGI_20200608 153.3 Diagnoses - main ICD10: C19 Malignant neoplasm of rectosigmoid junction Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 102 0.17 0.000648642 0.0829 0.522 0.49-0.555 OR 1.33 0.49-3.63 1.33 0.49-3.63 1.3 0.629-2.69 1.3 0.629-2.69 1.01 0.602-1.7 1.01 0.602-1.7 1.06 0.733-1.54 1.06 0.733-1.54 1.18 0.919-1.52 1.18 0.919-1.52 1.26 0.902-1.75 0.177 1.17 0.838-1.64 0.356 1.34 0.966-1.85 0.08 FALSE FALSE FALSE FALSE Both 325 3232 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode153-3-c21-p-5e-05-mgi-20200608 prsweb-phecode153-3-c21-p-5e-05-mgi-20200608 PRSWEB_PHECODE153.3_C21_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE153.3_C21_P_5e-05_MGI_20200608 153.3 Diagnoses - main ICD10: C21 Malignant neoplasm of anus and anal canal Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 64 0.44 0.00261431 0.083 0.509 0.475-0.544 OR 1.05 0.343-3.22 1.05 0.343-3.22 0.997 0.44-2.26 0.997 0.44-2.26 0.826 0.468-1.46 0.826 0.468-1.46 1.14 0.792-1.63 1.14 0.792-1.63 1.02 0.785-1.33 1.02 0.785-1.33 0.868 0.622-1.21 0.402 1.17 0.854-1.59 0.331 1.01 0.735-1.4 0.935 FALSE FALSE FALSE FALSE Both 325 3232 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode153-3-c3-anus-analcanal-p-5e-05-mgi-20200608 prsweb-phecode153-3-c3-anus-analcanal-p-5e-05-mgi-20200608 PRSWEB_PHECODE153.3_C3-ANUS-ANALCANAL_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE153.3_C3-ANUS-ANALCANAL_P_5e-05_MGI_20200608 153.3 Malignant neoplasm of anus and anal canal Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 70 0.74 0.00073509 0.083 0.496 0.465-0.53 OR 1.34 0.491-3.64 1.34 0.491-3.64 1.46 0.728-2.91 1.46 0.728-2.91 1.08 0.65-1.79 1.08 0.65-1.79 0.926 0.627-1.37 0.926 0.627-1.37 1.04 0.798-1.34 1.04 0.798-1.34 1.1 0.792-1.53 0.567 1.19 0.863-1.65 0.284 1.13 0.816-1.57 0.458 FALSE FALSE FALSE FALSE Both 325 3232 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode153-3-c3-rectum-p-5e-05-mgi-20200608 prsweb-phecode153-3-c3-rectum-p-5e-05-mgi-20200608 PRSWEB_PHECODE153.3_C3-RECTUM_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE153.3_C3-RECTUM_P_5e-05_MGI_20200608 153.3 Malignant neoplasm of rectum Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 155 0.72 0.000150999 0.083 0.504 0.475-0.537 OR 0.434 0.0827-2.28 0.434 0.0827-2.28 0.969 0.428-2.2 0.969 0.428-2.2 0.997 0.593-1.68 0.997 0.593-1.68 1.16 0.811-1.66 1.16 0.811-1.66 0.919 0.703-1.2 0.919 0.703-1.2 0.988 0.712-1.37 0.944 1.2 0.881-1.65 0.244 0.971 0.7-1.35 0.859 FALSE FALSE FALSE FALSE Both 325 3232 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode153-3-c20-p-5e-06-mgi-20200608 prsweb-phecode153-3-c20-p-5e-06-mgi-20200608 PRSWEB_PHECODE153.3_C20_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE153.3_C20_P_5e-06_MGI_20200608 153.3 Diagnoses - main ICD10: C20 Malignant neoplasm of rectum Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 19 0.93 0.000504886 0.083 0.49 0.459-0.522 OR 1.05 0.343-3.22 1.05 0.343-3.22 0.827 0.343-2 0.827 0.343-2 0.934 0.547-1.59 0.934 0.547-1.59 0.924 0.626-1.36 0.924 0.626-1.36 1.09 0.839-1.41 1.09 0.839-1.41 1.08 0.781-1.49 0.644 1.05 0.754-1.45 0.786 1.12 0.811-1.54 0.495 FALSE FALSE FALSE FALSE Both 325 3232 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode153-3-c21-p-5e-06-mgi-20200608 prsweb-phecode153-3-c21-p-5e-06-mgi-20200608 PRSWEB_PHECODE153.3_C21_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE153.3_C21_P_5e-06_MGI_20200608 153.3 Diagnoses - main ICD10: C21 Malignant neoplasm of anus and anal canal Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 16 0.52 0.00267936 0.083 0.499 0.467-0.535 OR 0.444 0.0847-2.33 0.444 0.0847-2.33 1.61 0.83-3.14 1.61 0.83-3.14 0.818 0.464-1.44 0.818 0.464-1.44 0.828 0.552-1.24 0.828 0.552-1.24 1.14 0.882-1.47 1.14 0.882-1.47 1.12 0.81-1.56 0.486 1.1 0.79-1.53 0.573 1.21 0.878-1.67 0.243 FALSE FALSE FALSE FALSE Both 325 3232 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode153-3-c3-rectum-p-5e-06-mgi-20200608 prsweb-phecode153-3-c3-rectum-p-5e-06-mgi-20200608 PRSWEB_PHECODE153.3_C3-RECTUM_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE153.3_C3-RECTUM_P_5e-06_MGI_20200608 153.3 Malignant neoplasm of rectum Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 19 0.36 1.46023e-05 0.083 0.493 0.462-0.526 OR 1.65 0.66-4.15 1.65 0.66-4.15 1.3 0.63-2.7 1.3 0.63-2.7 1.35 0.847-2.15 1.35 0.847-2.15 1.03 0.709-1.5 1.03 0.709-1.5 1.02 0.784-1.32 1.02 0.784-1.32 0.94 0.675-1.31 0.717 1.2 0.875-1.65 0.257 1.06 0.77-1.47 0.705 FALSE FALSE FALSE FALSE Both 325 3232 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode153-3-ukbb-saige-hrc-x153-3-p-5e-06-mgi-20200608 prsweb-phecode153-3-ukbb-saige-hrc-x153-3-p-5e-06-mgi-20200608 PRSWEB_PHECODE153.3_UKBB-SAIGE-HRC-X153.3_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE153.3_UKBB-SAIGE-HRC-X153.3_P_5e-06_MGI_20200608 153.3 Malignant neoplasm of rectum, rectosigmoid junction, and anus Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 17 0.45 0.000994186 0.083 0.502 0.466-0.533 OR 1.63 0.651-4.09 1.63 0.651-4.09 1.29 0.621-2.66 1.29 0.621-2.66 1.07 0.644-1.78 1.07 0.644-1.78 1.24 0.871-1.76 1.24 0.871-1.76 1.05 0.813-1.37 1.05 0.813-1.37 1.16 0.836-1.61 0.375 1.16 0.835-1.6 0.383 1.15 0.828-1.59 0.405 FALSE FALSE FALSE FALSE Both 325 3232 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode153-3-c21-p-5e-07-mgi-20200608 prsweb-phecode153-3-c21-p-5e-07-mgi-20200608 PRSWEB_PHECODE153.3_C21_P_5e-07_MGI_20200608 P_5e-07 PRSWEB_PHECODE153.3_C21_P_5e-07_MGI_20200608 153.3 Diagnoses - main ICD10: C21 Malignant neoplasm of anus and anal canal Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-07) UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 8 0.94 0.00180693 0.083 0.484 0.452-0.518 OR 1.04 0.341-3.2 1.04 0.341-3.2 0.988 0.436-2.24 0.988 0.436-2.24 0.821 0.466-1.45 0.821 0.466-1.45 0.996 0.681-1.46 0.996 0.681-1.46 1.05 0.813-1.37 1.05 0.813-1.37 1.02 0.74-1.41 0.899 1.02 0.741-1.41 0.889 1.06 0.769-1.46 0.724 FALSE FALSE FALSE FALSE Both 325 3232 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode153-3-c20-pt-mgi-20200608 prsweb-phecode153-3-c20-pt-mgi-20200608 PRSWEB_PHECODE153.3_C20_PT_MGI_20200608 P&T PRSWEB_PHECODE153.3_C20_PT_MGI_20200608 153.3 Diagnoses - main ICD10: C20 Malignant neoplasm of rectum Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative P&T UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 16 0.8 0.000759142 0.083 0.488 0.457-0.521 OR 1.04 0.34-3.19 1.04 0.34-3.19 0.986 0.435-2.23 0.986 0.435-2.23 0.943 0.553-1.61 0.943 0.553-1.61 1.09 0.759-1.58 1.09 0.759-1.58 1.04 0.798-1.34 1.04 0.798-1.34 1.11 0.805-1.54 0.517 1.13 0.815-1.56 0.467 1.12 0.808-1.55 0.498 FALSE FALSE FALSE FALSE Both 325 3232 GRCh37/hg19 P<=3.16e-06 2020-06-08 prsweb-phecode153-3-c21-pt-mgi-20200608 prsweb-phecode153-3-c21-pt-mgi-20200608 PRSWEB_PHECODE153.3_C21_PT_MGI_20200608 P&T PRSWEB_PHECODE153.3_C21_PT_MGI_20200608 153.3 Diagnoses - main ICD10: C21 Malignant neoplasm of anus and anal canal Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative P&T UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 46 0.34 0.00380837 0.083 0.512 0.477-0.547 OR 1.34 0.493-3.65 1.34 0.493-3.65 1.14 0.528-2.45 1.14 0.528-2.45 0.946 0.554-1.61 0.946 0.554-1.61 0.966 0.658-1.42 0.966 0.658-1.42 1.07 0.827-1.39 1.07 0.827-1.39 1.13 0.814-1.58 0.457 1.3 0.938-1.8 0.115 1.19 0.858-1.66 0.294 FALSE FALSE FALSE FALSE Both 325 3232 GRCh37/hg19 P<=3.16e-05 2020-06-08 prsweb-phecode153-3-c3-rectoisigmoid-junction-pt-mgi-20200608 prsweb-phecode153-3-c3-rectoisigmoid-junction-pt-mgi-20200608 PRSWEB_PHECODE153.3_C3-RECTOISIGMOID-JUNCTION_PT_MGI_20200608 P&T PRSWEB_PHECODE153.3_C3-RECTOISIGMOID-JUNCTION_PT_MGI_20200608 153.3 Malignant neoplasm of rectosigmoid junction Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative P&T UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 21 0.9 0.000835021 0.083 0.493 0.462-0.526 OR 0.731 0.199-2.69 0.731 0.199-2.69 0.827 0.343-2 0.827 0.343-2 1.21 0.747-1.97 1.21 0.747-1.97 1.27 0.895-1.8 1.27 0.895-1.8 1.05 0.806-1.36 1.05 0.806-1.36 1.01 0.734-1.39 0.952 0.93 0.671-1.29 0.661 1.02 0.742-1.41 0.895 FALSE FALSE FALSE FALSE Both 325 3232 GRCh37/hg19 P<=7.94e-06 2020-06-08 prsweb-phecode153-3-c3-rectum-pt-mgi-20200608 prsweb-phecode153-3-c3-rectum-pt-mgi-20200608 PRSWEB_PHECODE153.3_C3-RECTUM_PT_MGI_20200608 P&T PRSWEB_PHECODE153.3_C3-RECTUM_PT_MGI_20200608 153.3 Malignant neoplasm of rectum Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative P&T UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 110 0.84 0.000754129 0.083 0.5 0.47-0.533 OR 1.03 0.337-3.16 1.03 0.337-3.16 1.13 0.523-2.43 1.13 0.523-2.43 0.748 0.416-1.35 0.748 0.416-1.35 0.924 0.626-1.36 0.924 0.626-1.36 0.997 0.767-1.3 0.997 0.767-1.3 1.07 0.775-1.48 0.682 1.09 0.789-1.51 0.601 1.05 0.759-1.45 0.771 FALSE FALSE FALSE FALSE Both 325 3232 GRCh37/hg19 P<=3.16e-05 2020-06-08 prsweb-phecode153-3-ukbb-saige-hrc-x153-3-pt-mgi-20200608 prsweb-phecode153-3-ukbb-saige-hrc-x153-3-pt-mgi-20200608 PRSWEB_PHECODE153.3_UKBB-SAIGE-HRC-X153.3_PT_MGI_20200608 P&T PRSWEB_PHECODE153.3_UKBB-SAIGE-HRC-X153.3_PT_MGI_20200608 153.3 Malignant neoplasm of rectum, rectosigmoid junction, and anus Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative P&T UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 13 0.64 0.00171408 0.083 0.498 0.466-0.531 OR 2.28 1.01-5.12 2.28 1.01-5.12 1.15 0.533-2.47 1.15 0.533-2.47 0.947 0.556-1.62 0.947 0.556-1.62 0.999 0.683-1.46 0.999 0.683-1.46 1.12 0.869-1.45 1.12 0.869-1.45 1.15 0.83-1.59 0.405 1.02 0.735-1.42 0.898 1.16 0.844-1.61 0.354 FALSE FALSE FALSE FALSE Both 325 3232 GRCh37/hg19 P<=3.98e-06 2020-06-08 prsweb-phecode153-3-20001-1023-prs-cs-mgi-20200608 prsweb-phecode153-3-20001-1023-prs-cs-mgi-20200608 PRSWEB_PHECODE153.3_20001-1023_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE153.3_20001-1023_PRS-CS_MGI_20200608 153.3 Cancer code, self-reported: rectal cancer Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative PRS-CS UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1018916 0.61 0.000172588 0.083 0.507 0.475-0.54 OR 1.35 0.494-3.67 1.35 0.494-3.67 1.14 0.53-2.46 1.14 0.53-2.46 0.945 0.554-1.61 0.945 0.554-1.61 1.13 0.786-1.62 1.13 0.786-1.62 1.07 0.822-1.38 1.07 0.822-1.38 1.21 0.878-1.66 0.248 0.968 0.693-1.35 0.846 1.12 0.81-1.54 0.501 FALSE FALSE FALSE FALSE Both 325 3232 GRCh37/hg19 auto 2020-06-08 prsweb-phecode153-3-c19-prs-cs-mgi-20200608 prsweb-phecode153-3-c19-prs-cs-mgi-20200608 PRSWEB_PHECODE153.3_C19_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE153.3_C19_PRS-CS_MGI_20200608 153.3 Diagnoses - main ICD10: C19 Malignant neoplasm of rectosigmoid junction Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative PRS-CS UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1078799 0.04 0.000195485 0.0829 0.533 0.5-0.567 OR 1.34 0.491-3.65 1.34 0.491-3.65 1.76 0.929-3.34 1.76 0.929-3.34 1.6 1.04-2.48 1.6 1.04-2.48 1.39 0.988-1.95 1.39 0.988-1.95 1.26 0.984-1.62 1.26 0.984-1.62 1.23 0.885-1.71 0.218 1.05 0.747-1.47 0.782 1.39 1.01-1.92 0.0447 TRUE FALSE FALSE TRUE Both 325 3232 GRCh37/hg19 auto https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000383/ScoringFiles/ phewas/PRSWEB_PHECODE153.3_C19_PRS-CS_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE153.3_C19_PRS-CS_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode153-3-c20-prs-cs-mgi-20200608 prsweb-phecode153-3-c20-prs-cs-mgi-20200608 PRSWEB_PHECODE153.3_C20_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE153.3_C20_PRS-CS_MGI_20200608 153.3 Diagnoses - main ICD10: C20 Malignant neoplasm of rectum Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative PRS-CS UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1104940 0.34 0.000138122 0.083 0.521 0.488-0.553 OR 0 0-0 0 0-0 0.377 0.106-1.35 0.377 0.106-1.35 0.563 0.29-1.09 0.563 0.29-1.09 1.12 0.781-1.61 1.12 0.781-1.61 1.13 0.877-1.46 1.13 0.877-1.46 1.08 0.773-1.5 0.66 1.19 0.855-1.64 0.307 1.25 0.904-1.73 0.177 FALSE FALSE FALSE FALSE Both 325 3232 GRCh37/hg19 auto 2020-06-08 prsweb-phecode153-3-c21-prs-cs-mgi-20200608 prsweb-phecode153-3-c21-prs-cs-mgi-20200608 PRSWEB_PHECODE153.3_C21_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE153.3_C21_PRS-CS_MGI_20200608 153.3 Diagnoses - main ICD10: C21 Malignant neoplasm of anus and anal canal Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative PRS-CS UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 923679 0.19 0.000109097 0.0829 0.528 0.493-0.564 OR 1.65 0.658-4.13 1.65 0.658-4.13 1.44 0.72-2.88 1.44 0.72-2.88 1.2 0.739-1.95 1.2 0.739-1.95 1.2 0.84-1.71 1.2 0.84-1.71 1.44 1.12-1.84 1.44 1.12-1.84 0.817 0.582-1.15 0.242 0.937 0.675-1.3 0.695 1.31 0.968-1.78 0.0794 FALSE FALSE FALSE FALSE Both 325 3232 GRCh37/hg19 auto 2020-06-08 prsweb-phecode153-3-c3-anus-analcanal-prs-cs-mgi-20200608 prsweb-phecode153-3-c3-anus-analcanal-prs-cs-mgi-20200608 PRSWEB_PHECODE153.3_C3-ANUS-ANALCANAL_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE153.3_C3-ANUS-ANALCANAL_PRS-CS_MGI_20200608 153.3 Malignant neoplasm of anus and anal canal Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative PRS-CS UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 877060 0.12 0.000647598 0.0829 0.528 0.495-0.562 OR 1.33 0.487-3.61 1.33 0.487-3.61 1.29 0.625-2.68 1.29 0.625-2.68 1.33 0.835-2.12 1.33 0.835-2.12 1.3 0.921-1.84 1.3 0.921-1.84 1.3 1.01-1.67 1.3 1.01-1.67 1.08 0.779-1.51 0.635 1.03 0.736-1.43 0.877 1.34 0.974-1.83 0.072 FALSE FALSE FALSE FALSE Both 325 3232 GRCh37/hg19 auto 2020-06-08 prsweb-phecode153-3-c3-rectoisigmoid-junction-prs-cs-mgi-20200608 prsweb-phecode153-3-c3-rectoisigmoid-junction-prs-cs-mgi-20200608 PRSWEB_PHECODE153.3_C3-RECTOISIGMOID-JUNCTION_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE153.3_C3-RECTOISIGMOID-JUNCTION_PRS-CS_MGI_20200608 153.3 Malignant neoplasm of rectosigmoid junction Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative PRS-CS UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1040423 0.097 0.000407518 0.0829 0.533 0.503-0.565 OR 0.441 0.0841-2.31 0.441 0.0841-2.31 0.982 0.434-2.22 0.982 0.434-2.22 0.943 0.553-1.61 0.943 0.553-1.61 1.06 0.73-1.53 1.06 0.73-1.53 1.18 0.917-1.52 1.18 0.917-1.52 1.15 0.822-1.61 0.411 1.31 0.942-1.83 0.108 1.34 0.965-1.85 0.0812 FALSE FALSE FALSE FALSE Both 325 3232 GRCh37/hg19 auto 2020-06-08 prsweb-phecode153-3-c3-rectum-prs-cs-mgi-20200608 prsweb-phecode153-3-c3-rectum-prs-cs-mgi-20200608 PRSWEB_PHECODE153.3_C3-RECTUM_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE153.3_C3-RECTUM_PRS-CS_MGI_20200608 153.3 Malignant neoplasm of rectum Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative PRS-CS UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1104018 0.048 0.000530638 0.0829 0.531 0.495-0.563 OR 1.02 0.334-3.14 1.02 0.334-3.14 1.12 0.521-2.42 1.12 0.521-2.42 1.19 0.73-1.93 1.19 0.73-1.93 1.33 0.945-1.87 1.33 0.945-1.87 1.22 0.946-1.57 1.22 0.946-1.57 0.978 0.693-1.38 0.898 1.32 0.953-1.82 0.0946 1.35 0.98-1.87 0.0659 TRUE FALSE FALSE TRUE Both 325 3232 GRCh37/hg19 auto https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000384/ScoringFiles/ phewas/PRSWEB_PHECODE153.3_C3-RECTUM_PRS-CS_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE153.3_C3-RECTUM_PRS-CS_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode153-3-ukbb-saige-hrc-x153-3-prs-cs-mgi-20200608 prsweb-phecode153-3-ukbb-saige-hrc-x153-3-prs-cs-mgi-20200608 PRSWEB_PHECODE153.3_UKBB-SAIGE-HRC-X153.3_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE153.3_UKBB-SAIGE-HRC-X153.3_PRS-CS_MGI_20200608 153.3 Malignant neoplasm of rectum, rectosigmoid junction, and anus Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative PRS-CS UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1119238 0.074 0.000569835 0.0829 0.536 0.501-0.569 OR 0.737 0.2-2.72 0.737 0.2-2.72 0.983 0.435-2.23 0.983 0.435-2.23 1.47 0.939-2.3 1.47 0.939-2.3 1.21 0.846-1.72 1.21 0.846-1.72 1.28 1-1.65 1.28 1-1.65 0.813 0.575-1.15 0.244 1.18 0.854-1.62 0.32 1.3 0.945-1.78 0.107 FALSE FALSE FALSE FALSE Both 325 3232 GRCh37/hg19 auto 2020-06-08 prsweb-phecode153-3-20001-1023-lassosum-mgi-20200608 prsweb-phecode153-3-20001-1023-lassosum-mgi-20200608 PRSWEB_PHECODE153.3_20001-1023_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE153.3_20001-1023_LASSOSUM_MGI_20200608 153.3 Cancer code, self-reported: rectal cancer Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative lassosum UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 183063 0.59 0.000963595 0.083 0.507 0.47-0.541 OR 0.742 0.201-2.73 0.742 0.201-2.73 1.27 0.615-2.64 1.27 0.615-2.64 1.26 0.783-2.02 1.26 0.783-2.02 1.41 1.01-1.98 1.41 1.01-1.98 1.17 0.908-1.51 1.17 0.908-1.51 0.818 0.594-1.13 0.216 0.731 0.528-1.01 0.0599 0.987 0.728-1.34 0.933 FALSE FALSE FALSE FALSE Both 325 3232 GRCh37/hg19 s=1;Lambda=0.06158 2020-06-08 prsweb-phecode153-3-c19-lassosum-mgi-20200608 prsweb-phecode153-3-c19-lassosum-mgi-20200608 PRSWEB_PHECODE153.3_C19_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE153.3_C19_LASSOSUM_MGI_20200608 153.3 Diagnoses - main ICD10: C19 Malignant neoplasm of rectosigmoid junction Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative lassosum UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 2154790 0.081 0.000669785 0.0829 0.53 0.498-0.563 OR 0.441 0.0841-2.31 0.441 0.0841-2.31 0.974 0.43-2.21 0.974 0.43-2.21 1.47 0.935-2.3 1.47 0.935-2.3 1.24 0.869-1.76 1.24 0.869-1.76 1.26 0.979-1.62 1.26 0.979-1.62 1.13 0.808-1.58 0.477 1.17 0.841-1.64 0.346 1.38 0.997-1.91 0.0519 FALSE FALSE FALSE FALSE Both 325 3232 GRCh37/hg19 s=0.2;Lambda=0.002637 2020-06-08 prsweb-phecode153-3-c20-lassosum-mgi-20200608 prsweb-phecode153-3-c20-lassosum-mgi-20200608 PRSWEB_PHECODE153.3_C20_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE153.3_C20_LASSOSUM_MGI_20200608 153.3 Diagnoses - main ICD10: C20 Malignant neoplasm of rectum Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative lassosum UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 4790230 0.28 0.00158146 0.083 0.524 0.493-0.557 OR 0 0-0 0 0-0 0.825 0.342-1.99 0.825 0.342-1.99 1.01 0.598-1.69 1.01 0.598-1.69 1.09 0.757-1.58 1.09 0.757-1.58 1.12 0.866-1.45 1.12 0.866-1.45 1 0.715-1.4 0.995 1.24 0.901-1.71 0.186 1.2 0.865-1.65 0.28 FALSE FALSE FALSE FALSE Both 325 3232 GRCh37/hg19 s=1;Lambda=0.004281 2020-06-08 prsweb-phecode153-3-c21-lassosum-mgi-20200608 prsweb-phecode153-3-c21-lassosum-mgi-20200608 PRSWEB_PHECODE153.3_C21_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE153.3_C21_LASSOSUM_MGI_20200608 153.3 Diagnoses - main ICD10: C21 Malignant neoplasm of anus and anal canal Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative lassosum UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 67145 0.36 0.00218349 0.083 0.521 0.488-0.555 OR 1.06 0.345-3.25 1.06 0.345-3.25 0.837 0.347-2.02 0.837 0.347-2.02 0.759 0.422-1.37 0.759 0.422-1.37 0.895 0.604-1.33 0.895 0.604-1.33 1.05 0.811-1.36 1.05 0.811-1.36 1.16 0.827-1.62 0.396 1.36 0.985-1.89 0.0616 1.24 0.892-1.73 0.199 FALSE FALSE FALSE FALSE Both 325 3232 GRCh37/hg19 s=1;Lambda=0.1 2020-06-08 prsweb-phecode153-3-c3-anus-analcanal-lassosum-mgi-20200608 prsweb-phecode153-3-c3-anus-analcanal-lassosum-mgi-20200608 PRSWEB_PHECODE153.3_C3-ANUS-ANALCANAL_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE153.3_C3-ANUS-ANALCANAL_LASSOSUM_MGI_20200608 153.3 Malignant neoplasm of anus and anal canal Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative lassosum UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 79687 0.43 0.00181689 0.083 0.527 0.493-0.558 OR 1.34 0.493-3.65 1.34 0.493-3.65 0.834 0.346-2.01 0.834 0.346-2.01 0.886 0.512-1.54 0.886 0.512-1.54 1.03 0.705-1.49 1.03 0.705-1.49 1 0.769-1.3 1 0.769-1.3 0.958 0.681-1.35 0.804 1.41 1.03-1.93 0.0331 1.12 0.807-1.56 0.494 FALSE FALSE FALSE FALSE Both 325 3232 GRCh37/hg19 s=1;Lambda=0.1 2020-06-08 prsweb-phecode153-3-c3-rectoisigmoid-junction-lassosum-mgi-20200608 prsweb-phecode153-3-c3-rectoisigmoid-junction-lassosum-mgi-20200608 PRSWEB_PHECODE153.3_C3-RECTOISIGMOID-JUNCTION_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE153.3_C3-RECTOISIGMOID-JUNCTION_LASSOSUM_MGI_20200608 153.3 Malignant neoplasm of rectosigmoid junction Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative lassosum UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 592740 0.23 0.00102663 0.0829 0.526 0.496-0.561 OR 1.01 0.331-3.1 1.01 0.331-3.1 1.13 0.523-2.43 1.13 0.523-2.43 1.14 0.693-1.86 1.14 0.693-1.86 1.09 0.758-1.58 1.09 0.758-1.58 1.17 0.906-1.51 1.17 0.906-1.51 1.25 0.904-1.74 0.175 1.07 0.768-1.51 0.674 1.3 0.941-1.81 0.11 FALSE FALSE FALSE FALSE Both 325 3232 GRCh37/hg19 s=0.9;Lambda=0.02976 2020-06-08 prsweb-phecode153-3-c3-rectum-lassosum-mgi-20200608 prsweb-phecode153-3-c3-rectum-lassosum-mgi-20200608 PRSWEB_PHECODE153.3_C3-RECTUM_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE153.3_C3-RECTUM_LASSOSUM_MGI_20200608 153.3 Malignant neoplasm of rectum Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative lassosum UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1249593 0.45 0.000666083 0.083 0.508 0.473-0.541 OR 1.34 0.493-3.66 1.34 0.493-3.66 1.62 0.835-3.16 1.62 0.835-3.16 1.41 0.89-2.22 1.41 0.89-2.22 1.09 0.756-1.57 1.09 0.756-1.57 1.03 0.795-1.34 1.03 0.795-1.34 0.895 0.646-1.24 0.507 1.03 0.754-1.42 0.833 1.01 0.73-1.38 0.974 FALSE FALSE FALSE FALSE Both 325 3232 GRCh37/hg19 s=0.5;Lambda=0.006952 2020-06-08 prsweb-phecode153-3-ukbb-saige-hrc-x153-3-lassosum-mgi-20200608 prsweb-phecode153-3-ukbb-saige-hrc-x153-3-lassosum-mgi-20200608 PRSWEB_PHECODE153.3_UKBB-SAIGE-HRC-X153.3_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE153.3_UKBB-SAIGE-HRC-X153.3_LASSOSUM_MGI_20200608 153.3 Malignant neoplasm of rectum, rectosigmoid junction, and anus Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative lassosum UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 68 0.078 0.00140425 0.0829 0.525 0.492-0.556 OR 2.25 1-5.06 2.25 1-5.06 1.92 1.03-3.56 1.92 1.03-3.56 1.87 1.24-2.82 1.87 1.24-2.82 1.46 1.04-2.03 1.46 1.04-2.03 1.34 1.05-1.72 1.34 1.05-1.72 1.15 0.83-1.6 0.398 0.989 0.703-1.39 0.95 1.38 1-1.89 0.0485 FALSE FALSE FALSE FALSE Both 325 3232 GRCh37/hg19 s=0.5;Lambda=0.04833 2020-06-08 prsweb-phecode155-ukbb-saige-hrc-x155-p-5e-05-mgi-20200608 prsweb-phecode155-ukbb-saige-hrc-x155-p-5e-05-mgi-20200608 PRSWEB_PHECODE155_UKBB-SAIGE-HRC-X155_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE155_UKBB-SAIGE-HRC-X155_P_5e-05_MGI_20200608 155 Cancer of liver and intrahepatic bile duct Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 78 0.054 0.000762591 0.0825 0.533 0.492-0.573 OR 0.69 0.127-3.74 0.69 0.127-3.74 1.55 0.664-3.6 1.55 0.664-3.6 1.1 0.59-2.07 1.1 0.59-2.07 1.03 0.643-1.64 1.03 0.643-1.64 1.37 1-1.86 1.37 1-1.86 1.09 0.711-1.68 0.69 1.29 0.852-1.95 0.228 1.52 1.01-2.27 0.0426 FALSE FALSE FALSE FALSE Both 208 2080 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode155-c22-p-5e-06-mgi-20200608 prsweb-phecode155-c22-p-5e-06-mgi-20200608 PRSWEB_PHECODE155_C22_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE155_C22_P_5e-06_MGI_20200608 155 Diagnoses - main ICD10: C22 Malignant neoplasm of liver and intrahepatic bile ducts Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 11 0.9 0.000809312 0.0826 0.493 0.451-0.535 OR 0.696 0.128-3.77 0.696 0.128-3.77 1.04 0.388-2.8 1.04 0.388-2.8 0.9 0.456-1.78 0.9 0.456-1.78 0.769 0.457-1.3 0.769 0.457-1.3 1.14 0.831-1.57 1.14 0.831-1.57 1.09 0.738-1.62 0.658 0.835 0.55-1.27 0.4 1.1 0.743-1.63 0.632 FALSE FALSE FALSE FALSE Both 208 2080 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode155-c22-pt-mgi-20200608 prsweb-phecode155-c22-pt-mgi-20200608 PRSWEB_PHECODE155_C22_PT_MGI_20200608 P&T PRSWEB_PHECODE155_C22_PT_MGI_20200608 155 Diagnoses - main ICD10: C22 Malignant neoplasm of liver and intrahepatic bile ducts Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative P&T UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 9 0.55 0.00168422 0.0826 0.498 0.459-0.536 OR 1.62 0.51-5.18 1.62 0.51-5.18 1.05 0.391-2.82 1.05 0.391-2.82 0.897 0.454-1.77 0.897 0.454-1.77 1.26 0.814-1.96 1.26 0.814-1.96 1.01 0.726-1.4 1.01 0.726-1.4 1.31 0.882-1.95 0.18 1.06 0.702-1.61 0.772 1.12 0.743-1.69 0.59 FALSE FALSE FALSE FALSE Both 208 2080 GRCh37/hg19 P<=3.98e-06 2020-06-08 prsweb-phecode155-ukbb-saige-hrc-x155-prs-cs-mgi-20200608 prsweb-phecode155-ukbb-saige-hrc-x155-prs-cs-mgi-20200608 PRSWEB_PHECODE155_UKBB-SAIGE-HRC-X155_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE155_UKBB-SAIGE-HRC-X155_PRS-CS_MGI_20200608 155 Cancer of liver and intrahepatic bile duct Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative PRS-CS UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1119238 0.87 0.000196516 0.0826 0.504 0.458-0.548 OR 1.6 0.499-5.1 1.6 0.499-5.1 2 0.938-4.28 2 0.938-4.28 1.4 0.792-2.47 1.4 0.792-2.47 1.25 0.805-1.93 1.25 0.805-1.93 1.3 0.954-1.77 1.3 0.954-1.77 0.577 0.38-0.877 0.01 0.688 0.462-1.02 0.0658 0.979 0.679-1.41 0.911 FALSE FALSE FALSE FALSE Both 208 2080 GRCh37/hg19 auto 2020-06-08 prsweb-phecode155-ukbb-saige-hrc-x155-lassosum-mgi-20200608 prsweb-phecode155-ukbb-saige-hrc-x155-lassosum-mgi-20200608 PRSWEB_PHECODE155_UKBB-SAIGE-HRC-X155_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE155_UKBB-SAIGE-HRC-X155_LASSOSUM_MGI_20200608 155 Cancer of liver and intrahepatic bile duct Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative lassosum UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1007258 0.69 0.000610143 0.0826 0.506 0.467-0.547 OR 2.62 0.997-6.87 2.62 0.997-6.87 1.32 0.533-3.27 1.32 0.533-3.27 1.1 0.59-2.07 1.1 0.59-2.07 1.14 0.724-1.79 1.14 0.724-1.79 1.11 0.802-1.52 1.11 0.802-1.52 0.828 0.547-1.25 0.372 1.06 0.714-1.57 0.779 1.07 0.725-1.58 0.729 FALSE FALSE FALSE FALSE Both 208 2080 GRCh37/hg19 s=1;Lambda=0.03793 2020-06-08 prsweb-phecode155-1-ukbb-saige-hrc-x155-1-p-5e-05-mgi-20200608 prsweb-phecode155-1-ukbb-saige-hrc-x155-1-p-5e-05-mgi-20200608 PRSWEB_PHECODE155.1_UKBB-SAIGE-HRC-X155.1_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE155.1_UKBB-SAIGE-HRC-X155.1_P_5e-05_MGI_20200608 155.1 Malignant neoplasm of liver, primary Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 79 0.08 0.00128439 0.0824 0.53 0.48-0.578 OR 1.62 0.407-6.47 1.62 0.407-6.47 2.2 0.919-5.29 2.2 0.919-5.29 1.42 0.723-2.78 1.42 0.723-2.78 1.27 0.759-2.12 1.27 0.759-2.12 1.31 0.909-1.9 1.31 0.909-1.9 1.55 0.953-2.52 0.0775 1.08 0.64-1.84 0.762 1.54 0.947-2.51 0.0816 FALSE FALSE FALSE FALSE Both 147 1470 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode155-1-ukbb-saige-hrc-x155-1-p-5e-06-mgi-20200608 prsweb-phecode155-1-ukbb-saige-hrc-x155-1-p-5e-06-mgi-20200608 PRSWEB_PHECODE155.1_UKBB-SAIGE-HRC-X155.1_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE155.1_UKBB-SAIGE-HRC-X155.1_P_5e-06_MGI_20200608 155.1 Malignant neoplasm of liver, primary Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 9 0.57 0.00114412 0.0825 0.484 0.435-0.534 OR 2.21 0.664-7.38 2.21 0.664-7.38 2.13 0.889-5.1 2.13 0.889-5.1 1.43 0.732-2.79 1.43 0.732-2.79 1.21 0.714-2.04 1.21 0.714-2.04 1.01 0.684-1.48 1.01 0.684-1.48 1.46 0.906-2.36 0.119 1.19 0.725-1.95 0.491 1.24 0.758-2.04 0.389 FALSE FALSE FALSE FALSE Both 147 1470 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode155-1-ukbb-saige-hrc-x155-1-pt-mgi-20200608 prsweb-phecode155-1-ukbb-saige-hrc-x155-1-pt-mgi-20200608 PRSWEB_PHECODE155.1_UKBB-SAIGE-HRC-X155.1_PT_MGI_20200608 P&T PRSWEB_PHECODE155.1_UKBB-SAIGE-HRC-X155.1_PT_MGI_20200608 155.1 Malignant neoplasm of liver, primary Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative P&T UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 5 0.35 0.00220058 0.0825 0.473 0.427-0.52 OR 2.99 0.99-9.04 2.99 0.99-9.04 1.81 0.71-4.61 1.81 0.71-4.61 1.75 0.933-3.27 1.75 0.933-3.27 1.21 0.716-2.05 1.21 0.716-2.05 1.1 0.748-1.6 1.1 0.748-1.6 1.24 0.769-2.01 0.374 1.07 0.651-1.76 0.787 1.2 0.735-1.94 0.472 FALSE FALSE FALSE FALSE Both 147 1470 GRCh37/hg19 P<=2.51e-06 2020-06-08 prsweb-phecode155-1-ukbb-saige-hrc-x155-1-prs-cs-mgi-20200608 prsweb-phecode155-1-ukbb-saige-hrc-x155-1-prs-cs-mgi-20200608 PRSWEB_PHECODE155.1_UKBB-SAIGE-HRC-X155.1_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE155.1_UKBB-SAIGE-HRC-X155.1_PRS-CS_MGI_20200608 155.1 Malignant neoplasm of liver, primary Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative PRS-CS UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1119238 0.6 0.00220538 0.0825 0.506 0.459-0.555 OR 2.25 0.672-7.54 2.25 0.672-7.54 1.14 0.37-3.53 1.14 0.37-3.53 0.725 0.3-1.75 0.725 0.3-1.75 1.44 0.878-2.37 1.44 0.878-2.37 1.09 0.746-1.6 1.09 0.746-1.6 1 0.628-1.61 0.986 0.908 0.562-1.47 0.693 1.03 0.644-1.64 0.906 FALSE FALSE FALSE FALSE Both 147 1470 GRCh37/hg19 auto 2020-06-08 prsweb-phecode155-1-ukbb-saige-hrc-x155-1-lassosum-mgi-20200608 prsweb-phecode155-1-ukbb-saige-hrc-x155-1-lassosum-mgi-20200608 PRSWEB_PHECODE155.1_UKBB-SAIGE-HRC-X155.1_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE155.1_UKBB-SAIGE-HRC-X155.1_LASSOSUM_MGI_20200608 155.1 Malignant neoplasm of liver, primary Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative lassosum UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 6162796 0.77 0.00201008 0.0826 0.498 0.452-0.548 OR 2.24 0.672-7.44 2.24 0.672-7.44 1.82 0.715-4.63 1.82 0.715-4.63 1.16 0.556-2.4 1.16 0.556-2.4 1.21 0.716-2.05 1.21 0.716-2.05 0.915 0.616-1.36 0.915 0.616-1.36 0.982 0.615-1.57 0.938 0.996 0.625-1.59 0.988 0.893 0.553-1.44 0.645 FALSE FALSE FALSE FALSE Both 147 1470 GRCh37/hg19 s=1;Lambda=0.001 2020-06-08 prsweb-phecode157-gwas-catalog-r2019-05-03-x157-p-5e-05-mgi-20200608 prsweb-phecode157-gwas-catalog-r2019-05-03-x157-p-5e-05-mgi-20200608 PRSWEB_PHECODE157_GWAS-Catalog-r2019-05-03-X157_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE157_GWAS-Catalog-r2019-05-03-X157_P_5e-05_MGI_20200608 157 Pancreatic cancer Binary 33 unique SNPs MGI Michigan Genomics Initiative Fixed threshold (5e-05) GWAS Catalog (2019-05-03) 19648918;23180869;25086665;27579533;29422604 https://www.ncbi.nlm.nih.gov/pubmed/?term=19648918+23180869+25086665+27579533+29422604 32 0.055 0.00534528 0.0827 0.532 0.491-0.573 OR 2.46 0.942-6.41 2.46 0.942-6.41 1.75 0.789-3.86 1.75 0.789-3.86 1.7 1-2.88 1.7 1-2.88 1.45 0.959-2.19 1.45 0.959-2.19 1.28 0.94-1.74 1.28 0.94-1.74 1.32 0.875-1.98 0.187 1.08 0.706-1.66 0.718 1.41 0.947-2.11 0.0904 FALSE FALSE FALSE FALSE Both 211 2102 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode157-c25-p-5e-06-mgi-20200608 prsweb-phecode157-c25-p-5e-06-mgi-20200608 PRSWEB_PHECODE157_C25_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE157_C25_P_5e-06_MGI_20200608 157 Diagnoses - main ICD10: C25 Malignant neoplasm of pancreas Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 17 0.83 2.94267e-06 0.0829 0.492 0.448-0.533 OR 1.04 0.273-3.99 1.04 0.273-3.99 1.23 0.494-3.04 1.23 0.494-3.04 1.06 0.568-1.99 1.06 0.568-1.99 1 0.629-1.6 1 0.629-1.6 1.06 0.767-1.46 1.06 0.767-1.46 1.06 0.709-1.6 0.765 1.13 0.754-1.68 0.564 1.07 0.717-1.61 0.732 FALSE FALSE FALSE FALSE Both 211 2102 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode157-gwas-catalog-r2019-05-03-x157-p-5e-06-mgi-20200608 prsweb-phecode157-gwas-catalog-r2019-05-03-x157-p-5e-06-mgi-20200608 PRSWEB_PHECODE157_GWAS-Catalog-r2019-05-03-X157_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE157_GWAS-Catalog-r2019-05-03-X157_P_5e-06_MGI_20200608 157 Pancreatic cancer Binary 33 unique SNPs MGI Michigan Genomics Initiative Fixed threshold (5e-06) GWAS Catalog (2019-05-03) 19648918;23180869;25086665;27579533;29422604 https://www.ncbi.nlm.nih.gov/pubmed/?term=19648918+23180869+25086665+27579533+29422604 30 0.11 0.005976 0.0828 0.526 0.486-0.567 OR 1.54 0.486-4.87 1.54 0.486-4.87 1.75 0.791-3.86 1.75 0.791-3.86 1.58 0.923-2.72 1.58 0.923-2.72 1.23 0.793-1.9 1.23 0.793-1.9 1.25 0.918-1.71 1.25 0.918-1.71 1.46 0.977-2.19 0.0649 0.979 0.634-1.51 0.925 1.42 0.945-2.12 0.092 FALSE FALSE FALSE FALSE Both 211 2102 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode157-gwas-catalog-r2019-05-03-x157-p-5e-07-mgi-20200608 prsweb-phecode157-gwas-catalog-r2019-05-03-x157-p-5e-07-mgi-20200608 PRSWEB_PHECODE157_GWAS-Catalog-r2019-05-03-X157_P_5e-07_MGI_20200608 P_5e-07 PRSWEB_PHECODE157_GWAS-Catalog-r2019-05-03-X157_P_5e-07_MGI_20200608 157 Pancreatic cancer Binary 33 unique SNPs MGI Michigan Genomics Initiative Fixed threshold (5e-07) GWAS Catalog (2019-05-03) 19648918;23180869;25086665;27579533;29422604 https://www.ncbi.nlm.nih.gov/pubmed/?term=19648918+23180869+25086665+27579533+29422604 21 0.11 0.011955 0.0828 0.533 0.492-0.575 OR 1.1 0.287-4.18 1.1 0.287-4.18 1.74 0.787-3.86 1.74 0.787-3.86 1.69 0.999-2.87 1.69 0.999-2.87 1.22 0.79-1.89 1.22 0.79-1.89 1.4 1.03-1.9 1.4 1.03-1.9 0.981 0.651-1.48 0.927 0.93 0.612-1.41 0.734 1.36 0.928-2 0.114 FALSE FALSE FALSE FALSE Both 211 2102 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode157-gwas-catalog-r2019-05-03-x157-p-5e-09-mgi-20200608 prsweb-phecode157-gwas-catalog-r2019-05-03-x157-p-5e-09-mgi-20200608 PRSWEB_PHECODE157_GWAS-Catalog-r2019-05-03-X157_P_5e-09_MGI_20200608 P_5e-09 PRSWEB_PHECODE157_GWAS-Catalog-r2019-05-03-X157_P_5e-09_MGI_20200608 157 Pancreatic cancer Binary 33 unique SNPs MGI Michigan Genomics Initiative Fixed threshold (5e-09) GWAS Catalog (2019-05-03) 19648918;23180869;25086665;27579533;29422604 https://www.ncbi.nlm.nih.gov/pubmed/?term=19648918+23180869+25086665+27579533+29422604 10 0.13 0.0107208 0.0828 0.52 0.48-0.56 OR 1.08 0.284-4.12 1.08 0.284-4.12 1.01 0.377-2.72 1.01 0.377-2.72 0.975 0.509-1.87 0.975 0.509-1.87 1.51 1-2.27 1.51 1-2.27 1.31 0.966-1.79 1.31 0.966-1.79 0.965 0.64-1.45 0.863 1 0.664-1.51 0.997 1.29 0.874-1.9 0.201 FALSE FALSE FALSE FALSE Both 211 2102 GRCh37/hg19 P<=5e-09 2020-06-08 prsweb-phecode157-gwas-catalog-r2019-05-03-x157-p-5e-08-mgi-20200608 prsweb-phecode157-gwas-catalog-r2019-05-03-x157-p-5e-08-mgi-20200608 PRSWEB_PHECODE157_GWAS-Catalog-r2019-05-03-X157_P_5e-08_MGI_20200608 P_5e-08 PRSWEB_PHECODE157_GWAS-Catalog-r2019-05-03-X157_P_5e-08_MGI_20200608 157 Pancreatic cancer Binary 33 unique SNPs MGI Michigan Genomics Initiative GWAS Hits GWAS Catalog (2019-05-03) 19648918;23180869;25086665;27579533;29422604 https://www.ncbi.nlm.nih.gov/pubmed/?term=19648918+23180869+25086665+27579533+29422604 17 0.051 0.0107488 0.0827 0.534 0.492-0.577 OR 1.99 0.704-5.62 1.99 0.704-5.62 2.46 1.23-4.92 2.46 1.23-4.92 2.11 1.3-3.44 2.11 1.3-3.44 1.45 0.96-2.19 1.45 0.96-2.19 1.4 1.03-1.9 1.4 1.03-1.9 0.8 0.526-1.21 0.294 0.936 0.624-1.4 0.749 1.26 0.865-1.85 0.226 FALSE FALSE FALSE FALSE Both 211 2102 GRCh37/hg19 P<=5e-08 2020-06-08 prsweb-phecode157-c25-pt-mgi-20200608 prsweb-phecode157-c25-pt-mgi-20200608 PRSWEB_PHECODE157_C25_PT_MGI_20200608 P&T PRSWEB_PHECODE157_C25_PT_MGI_20200608 157 Diagnoses - main ICD10: C25 Malignant neoplasm of pancreas Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative P&T UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 6 0.42 0.000559201 0.0828 0.486 0.445-0.529 OR 2.01 0.711-5.67 2.01 0.711-5.67 1.74 0.785-3.85 1.74 0.785-3.85 1.08 0.577-2.01 1.08 0.577-2.01 1.33 0.869-2.03 1.33 0.869-2.03 1.24 0.913-1.7 1.24 0.913-1.7 0.757 0.5-1.15 0.189 0.863 0.578-1.29 0.472 1.08 0.738-1.59 0.685 FALSE FALSE FALSE FALSE Both 211 2102 GRCh37/hg19 P<=1.26e-06 2020-06-08 prsweb-phecode157-gwas-catalog-r2019-05-03-x157-pt-mgi-20200608 prsweb-phecode157-gwas-catalog-r2019-05-03-x157-pt-mgi-20200608 PRSWEB_PHECODE157_GWAS-Catalog-r2019-05-03-X157_PT_MGI_20200608 P&T PRSWEB_PHECODE157_GWAS-Catalog-r2019-05-03-X157_PT_MGI_20200608 157 Pancreatic cancer Binary 33 unique SNPs MGI Michigan Genomics Initiative P&T GWAS Catalog (2019-05-03) 19648918;23180869;25086665;27579533;29422604 https://www.ncbi.nlm.nih.gov/pubmed/?term=19648918+23180869+25086665+27579533+29422604 18 0.051 0.0133989 0.0827 0.537 0.493-0.579 OR 1.54 0.487-4.9 1.54 0.487-4.9 1.73 0.781-3.82 1.73 0.781-3.82 1.8 1.07-3.02 1.8 1.07-3.02 1.45 0.96-2.19 1.45 0.96-2.19 1.31 0.966-1.79 1.31 0.966-1.79 0.915 0.601-1.39 0.681 1.12 0.745-1.67 0.592 1.32 0.894-1.95 0.162 FALSE FALSE FALSE FALSE Both 211 2102 GRCh37/hg19 P<=7.94e-08 2020-06-08 prsweb-phecode157-ukbb-saige-hrc-x157-pt-mgi-20200608 prsweb-phecode157-ukbb-saige-hrc-x157-pt-mgi-20200608 PRSWEB_PHECODE157_UKBB-SAIGE-HRC-X157_PT_MGI_20200608 P&T PRSWEB_PHECODE157_UKBB-SAIGE-HRC-X157_PT_MGI_20200608 157 Pancreatic cancer Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative P&T UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 18 0.9 0.00131275 0.0829 0.49 0.449-0.531 OR 1.09 0.288-4.16 1.09 0.288-4.16 1.01 0.375-2.71 1.01 0.375-2.71 0.858 0.434-1.69 0.858 0.434-1.69 0.944 0.586-1.52 0.944 0.586-1.52 1.13 0.82-1.55 1.13 0.82-1.55 1.04 0.703-1.55 0.834 0.876 0.581-1.32 0.527 1.06 0.716-1.58 0.76 FALSE FALSE FALSE FALSE Both 211 2102 GRCh37/hg19 P<=1.26e-05 2020-06-08 prsweb-phecode157-c3-pancreas-prs-cs-mgi-20200608 prsweb-phecode157-c3-pancreas-prs-cs-mgi-20200608 PRSWEB_PHECODE157_C3-PANCREAS_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE157_C3-PANCREAS_PRS-CS_MGI_20200608 157 Malignant neoplasm of pancreas Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative PRS-CS UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1062840 0.47 0.000126267 0.0829 0.506 0.464-0.548 OR 2.49 0.954-6.52 2.49 0.954-6.52 1.98 0.931-4.21 1.98 0.931-4.21 1.58 0.917-2.7 1.58 0.917-2.7 1.44 0.951-2.18 1.44 0.951-2.18 1.06 0.769-1.46 1.06 0.769-1.46 1.11 0.749-1.65 0.598 0.996 0.664-1.49 0.984 1.08 0.723-1.6 0.718 FALSE FALSE FALSE FALSE Both 211 2102 GRCh37/hg19 auto 2020-06-08 prsweb-phecode157-ukbb-saige-hrc-x157-prs-cs-mgi-20200608 prsweb-phecode157-ukbb-saige-hrc-x157-prs-cs-mgi-20200608 PRSWEB_PHECODE157_UKBB-SAIGE-HRC-X157_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE157_UKBB-SAIGE-HRC-X157_PRS-CS_MGI_20200608 157 Pancreatic cancer Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative PRS-CS UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1119238 0.26 0.000298045 0.0828 0.524 0.482-0.564 OR 1.98 0.701-5.62 1.98 0.701-5.62 1.26 0.508-3.1 1.26 0.508-3.1 1.27 0.705-2.27 1.27 0.705-2.27 1.12 0.713-1.76 1.12 0.713-1.76 1.19 0.871-1.63 1.19 0.871-1.63 0.864 0.569-1.31 0.494 1.11 0.751-1.65 0.592 1.19 0.805-1.76 0.384 FALSE FALSE FALSE FALSE Both 211 2102 GRCh37/hg19 auto 2020-06-08 prsweb-phecode157-c25-lassosum-mgi-20200608 prsweb-phecode157-c25-lassosum-mgi-20200608 PRSWEB_PHECODE157_C25_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE157_C25_LASSOSUM_MGI_20200608 157 Diagnoses - main ICD10: C25 Malignant neoplasm of pancreas Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative lassosum UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 2230 0.31 0.00420642 0.0828 0.517 0.476-0.556 OR 1.96 0.691-5.55 1.96 0.691-5.55 2.43 1.21-4.87 2.43 1.21-4.87 1.47 0.843-2.55 1.47 0.843-2.55 1.16 0.744-1.81 1.16 0.744-1.81 1.27 0.934-1.73 1.27 0.934-1.73 0.772 0.508-1.17 0.225 0.969 0.654-1.44 0.873 1.18 0.807-1.73 0.394 FALSE FALSE FALSE FALSE Both 211 2102 GRCh37/hg19 s=0.2;Lambda=0.07848 2020-06-08 prsweb-phecode157-c3-pancreas-lassosum-mgi-20200608 prsweb-phecode157-c3-pancreas-lassosum-mgi-20200608 PRSWEB_PHECODE157_C3-PANCREAS_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE157_C3-PANCREAS_LASSOSUM_MGI_20200608 157 Malignant neoplasm of pancreas Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative lassosum UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 174 0.41 0.00459347 0.0828 0.506 0.464-0.55 OR 1.11 0.292-4.21 1.11 0.292-4.21 1.26 0.512-3.11 1.26 0.512-3.11 1.37 0.778-2.42 1.37 0.778-2.42 1.56 1.04-2.33 1.56 1.04-2.33 1.17 0.852-1.6 1.17 0.852-1.6 1.1 0.744-1.63 0.628 0.866 0.572-1.31 0.496 1.18 0.796-1.74 0.414 FALSE FALSE FALSE FALSE Both 211 2102 GRCh37/hg19 s=1;Lambda=0.1 2020-06-08 prsweb-phecode157-gwas-catalog-r2019-05-03-x157-p-5e-05-ukb-20200608 prsweb-phecode157-gwas-catalog-r2019-05-03-x157-p-5e-05-ukb-20200608 PRSWEB_PHECODE157_GWAS-Catalog-r2019-05-03-X157_P_5e-05_UKB_20200608 P_5e-05 PRSWEB_PHECODE157_GWAS-Catalog-r2019-05-03-X157_P_5e-05_UKB_20200608 157 Pancreatic cancer Binary 33 unique SNPs UKB UK Biobank Fixed threshold (5e-05) GWAS Catalog (2019-05-03) 19648918;23180869;25086665;27579533;29422604 https://www.ncbi.nlm.nih.gov/pubmed/?term=19648918+23180869+25086665+27579533+29422604 32 9.7e-05 0.00599105 0.0824 0.56 0.528-0.595 OR 1.96 0.832-4.63 1.96 0.832-4.63 2.24 1.25-4.01 2.24 1.25-4.01 1.79 1.18-2.72 1.79 1.18-2.72 1.41 1.01-1.97 1.41 1.01-1.97 1.38 1.08-1.77 1.38 1.08-1.77 0.879 0.612-1.26 0.483 1.44 1.04-1.99 0.0264 1.53 1.11-2.11 0.0089 TRUE FALSE FALSE FALSE Both 327 3264 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode157-gwas-catalog-r2019-05-03-x157-p-5e-06-ukb-20200608 prsweb-phecode157-gwas-catalog-r2019-05-03-x157-p-5e-06-ukb-20200608 PRSWEB_PHECODE157_GWAS-Catalog-r2019-05-03-X157_P_5e-06_UKB_20200608 P_5e-06 PRSWEB_PHECODE157_GWAS-Catalog-r2019-05-03-X157_P_5e-06_UKB_20200608 157 Pancreatic cancer Binary 33 unique SNPs UKB UK Biobank Fixed threshold (5e-06) GWAS Catalog (2019-05-03) 19648918;23180869;25086665;27579533;29422604 https://www.ncbi.nlm.nih.gov/pubmed/?term=19648918+23180869+25086665+27579533+29422604 30 0.00043 0.00519884 0.0825 0.554 0.522-0.588 OR 2.56 1.19-5.53 2.56 1.19-5.53 2.06 1.13-3.76 2.06 1.13-3.76 1.72 1.13-2.63 1.72 1.13-2.63 1.52 1.1-2.11 1.52 1.1-2.11 1.33 1.03-1.7 1.33 1.03-1.7 1.29 0.917-1.83 0.142 1.4 0.996-1.96 0.0529 1.63 1.17-2.27 0.00373 TRUE FALSE FALSE FALSE Both 327 3264 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode157-gwas-catalog-r2019-05-03-x157-p-5e-07-ukb-20200608 prsweb-phecode157-gwas-catalog-r2019-05-03-x157-p-5e-07-ukb-20200608 PRSWEB_PHECODE157_GWAS-Catalog-r2019-05-03-X157_P_5e-07_UKB_20200608 P_5e-07 PRSWEB_PHECODE157_GWAS-Catalog-r2019-05-03-X157_P_5e-07_UKB_20200608 157 Pancreatic cancer Binary 33 unique SNPs UKB UK Biobank Fixed threshold (5e-07) GWAS Catalog (2019-05-03) 19648918;23180869;25086665;27579533;29422604 https://www.ncbi.nlm.nih.gov/pubmed/?term=19648918+23180869+25086665+27579533+29422604 21 4.9e-07 0.00902801 0.0822 0.588 0.556-0.621 OR 2.57 1.19-5.55 2.57 1.19-5.55 2.06 1.13-3.75 2.06 1.13-3.75 1.39 0.88-2.19 1.39 0.88-2.19 1.16 0.809-1.66 1.16 0.809-1.66 1.65 1.3-2.1 1.65 1.3-2.1 1.3 0.894-1.89 0.17 1.83 1.29-2.6 0.000756 2.3 1.63-3.23 1.78e-06 TRUE FALSE FALSE FALSE Both 327 3264 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode157-gwas-catalog-r2019-05-03-x157-p-5e-09-ukb-20200608 prsweb-phecode157-gwas-catalog-r2019-05-03-x157-p-5e-09-ukb-20200608 PRSWEB_PHECODE157_GWAS-Catalog-r2019-05-03-X157_P_5e-09_UKB_20200608 P_5e-09 PRSWEB_PHECODE157_GWAS-Catalog-r2019-05-03-X157_P_5e-09_UKB_20200608 157 Pancreatic cancer Binary 33 unique SNPs UKB UK Biobank Fixed threshold (5e-09) GWAS Catalog (2019-05-03) 19648918;23180869;25086665;27579533;29422604 https://www.ncbi.nlm.nih.gov/pubmed/?term=19648918+23180869+25086665+27579533+29422604 10 3.3e-07 0.0145297 0.0822 0.579 0.548-0.611 OR 1.64 0.655-4.12 1.64 0.655-4.12 2.55 1.46-4.43 2.55 1.46-4.43 1.8 1.19-2.72 1.8 1.19-2.72 1.87 1.37-2.55 1.87 1.37-2.55 1.63 1.28-2.07 1.63 1.28-2.07 1.51 1.05-2.17 0.0263 1.62 1.13-2.32 0.00826 2.24 1.6-3.15 3.27e-06 TRUE FALSE FALSE FALSE Both 327 3264 GRCh37/hg19 P<=5e-09 2020-06-08 prsweb-phecode157-gwas-catalog-r2019-05-03-x157-p-5e-08-ukb-20200608 prsweb-phecode157-gwas-catalog-r2019-05-03-x157-p-5e-08-ukb-20200608 PRSWEB_PHECODE157_GWAS-Catalog-r2019-05-03-X157_P_5e-08_UKB_20200608 P_5e-08 PRSWEB_PHECODE157_GWAS-Catalog-r2019-05-03-X157_P_5e-08_UKB_20200608 157 Pancreatic cancer Binary 33 unique SNPs UKB UK Biobank GWAS Hits GWAS Catalog (2019-05-03) 19648918;23180869;25086665;27579533;29422604 https://www.ncbi.nlm.nih.gov/pubmed/?term=19648918+23180869+25086665+27579533+29422604 17 2.4e-08 0.0132491 0.082 0.589 0.559-0.622 OR 2.58 1.19-5.57 2.58 1.19-5.57 2.07 1.14-3.78 2.07 1.14-3.78 2.07 1.4-3.08 2.07 1.4-3.08 1.67 1.22-2.3 1.67 1.22-2.3 1.79 1.41-2.27 1.79 1.41-2.27 1.53 1.06-2.21 0.0244 1.66 1.15-2.39 0.00655 2.49 1.76-3.5 1.94e-07 TRUE FALSE FALSE TRUE Both 327 3264 GRCh37/hg19 P<=5e-08 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000385/ScoringFiles/ phewas/PRSWEB_PHECODE157_GWAS-Catalog-r2019-05-03-X157_P_5e-08_UKB_20200608/all.tsv phewas/PRSWEB_PHECODE157_GWAS-Catalog-r2019-05-03-X157_P_5e-08_UKB_20200608/exclusion.tsv 2020-06-08 prsweb-phecode157-gwas-catalog-r2019-05-03-x157-pt-ukb-20200608 prsweb-phecode157-gwas-catalog-r2019-05-03-x157-pt-ukb-20200608 PRSWEB_PHECODE157_GWAS-Catalog-r2019-05-03-X157_PT_UKB_20200608 P&T PRSWEB_PHECODE157_GWAS-Catalog-r2019-05-03-X157_PT_UKB_20200608 157 Pancreatic cancer Binary 33 unique SNPs UKB UK Biobank P&T GWAS Catalog (2019-05-03) 19648918;23180869;25086665;27579533;29422604 https://www.ncbi.nlm.nih.gov/pubmed/?term=19648918+23180869+25086665+27579533+29422604 10 3.3e-07 0.0145297 0.0822 0.579 0.548-0.611 OR 1.64 0.655-4.12 1.64 0.655-4.12 2.55 1.46-4.43 2.55 1.46-4.43 1.8 1.19-2.72 1.8 1.19-2.72 1.87 1.37-2.55 1.87 1.37-2.55 1.63 1.28-2.07 1.63 1.28-2.07 1.51 1.05-2.17 0.0263 1.62 1.13-2.32 0.00826 2.24 1.6-3.15 3.27e-06 TRUE FALSE FALSE TRUE Both 327 3264 GRCh37/hg19 P<=5e-09 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000386/ScoringFiles/ phewas/PRSWEB_PHECODE157_GWAS-Catalog-r2019-05-03-X157_PT_UKB_20200608/all.tsv phewas/PRSWEB_PHECODE157_GWAS-Catalog-r2019-05-03-X157_PT_UKB_20200608/exclusion.tsv 2020-06-08 prsweb-phecode159-c3-digestive-organs-p-5e-05-mgi-20200608 prsweb-phecode159-c3-digestive-organs-p-5e-05-mgi-20200608 PRSWEB_PHECODE159_C3-DIGESTIVE-ORGANS_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE159_C3-DIGESTIVE-ORGANS_P_5e-05_MGI_20200608 159 Malignant neoplasm of digestive organs Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 130 0.45 0.000337678 0.0826 0.508 0.477-0.538 OR 2.43 1.18-5 2.43 1.18-5 1.49 0.79-2.79 1.49 0.79-2.79 0.787 0.464-1.33 0.787 0.464-1.33 1.14 0.821-1.6 1.14 0.821-1.6 1.12 0.881-1.41 1.12 0.881-1.41 1.1 0.815-1.49 0.524 1.13 0.834-1.53 0.434 1.21 0.896-1.63 0.215 FALSE FALSE FALSE FALSE Both 383 3827 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode159-c3-digestive-organs-p-5e-06-mgi-20200608 prsweb-phecode159-c3-digestive-organs-p-5e-06-mgi-20200608 PRSWEB_PHECODE159_C3-DIGESTIVE-ORGANS_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE159_C3-DIGESTIVE-ORGANS_P_5e-06_MGI_20200608 159 Malignant neoplasm of digestive organs Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 29 0.24 5.58812e-05 0.0826 0.505 0.476-0.533 OR 1.94 0.875-4.29 1.94 0.875-4.29 1.51 0.806-2.85 1.51 0.806-2.85 1.24 0.794-1.92 1.24 0.794-1.92 1.21 0.871-1.67 1.21 0.871-1.67 0.994 0.78-1.27 0.994 0.78-1.27 1.27 0.942-1.72 0.116 1.18 0.875-1.6 0.274 1.15 0.845-1.56 0.379 FALSE FALSE FALSE FALSE Both 383 3827 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode159-c3-digestive-organs-p-5e-07-mgi-20200608 prsweb-phecode159-c3-digestive-organs-p-5e-07-mgi-20200608 PRSWEB_PHECODE159_C3-DIGESTIVE-ORGANS_P_5e-07_MGI_20200608 P_5e-07 PRSWEB_PHECODE159_C3-DIGESTIVE-ORGANS_P_5e-07_MGI_20200608 159 Malignant neoplasm of digestive organs Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-07) UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 6 0.082 0.000554844 0.0826 0.503 0.472-0.532 OR 1.38 0.556-3.41 1.38 0.556-3.41 1.88 1.06-3.34 1.88 1.06-3.34 1.63 1.09-2.43 1.63 1.09-2.43 1.36 0.995-1.86 1.36 0.995-1.86 1.2 0.95-1.51 1.2 0.95-1.51 1.17 0.868-1.58 0.299 0.997 0.731-1.36 0.986 1.25 0.93-1.68 0.138 FALSE FALSE FALSE FALSE Both 383 3827 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode159-c3-digestive-organs-pt-mgi-20200608 prsweb-phecode159-c3-digestive-organs-pt-mgi-20200608 PRSWEB_PHECODE159_C3-DIGESTIVE-ORGANS_PT_MGI_20200608 P&T PRSWEB_PHECODE159_C3-DIGESTIVE-ORGANS_PT_MGI_20200608 159 Malignant neoplasm of digestive organs Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative P&T UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 18 0.29 0.000918461 0.0826 0.497 0.466-0.526 OR 2.44 1.18-5.03 2.44 1.18-5.03 1.89 1.06-3.35 1.89 1.06-3.35 1.35 0.879-2.07 1.35 0.879-2.07 1.03 0.729-1.45 1.03 0.729-1.45 1.15 0.911-1.46 1.15 0.911-1.46 0.867 0.643-1.17 0.35 0.875 0.65-1.18 0.379 1.04 0.783-1.39 0.779 FALSE FALSE FALSE FALSE Both 383 3827 GRCh37/hg19 P<=2.51e-06 2020-06-08 prsweb-phecode159-c3-digestive-organs-lassosum-mgi-20200608 prsweb-phecode159-c3-digestive-organs-lassosum-mgi-20200608 PRSWEB_PHECODE159_C3-DIGESTIVE-ORGANS_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE159_C3-DIGESTIVE-ORGANS_LASSOSUM_MGI_20200608 159 Malignant neoplasm of digestive organs Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative lassosum UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 4 0.62 0.00149471 0.0826 0.505 0.474-0.535 OR 3.75 2.02-6.95 3.75 2.02-6.95 1.98 1.15-3.41 1.98 1.15-3.41 0.99 0.773-1.27 0.99 0.773-1.27 0.99 0.773-1.27 0.99 0.773-1.27 1.01 0.792-1.28 1.01 0.792-1.28 0.851 0.548-1.32 0.474 0.748 0.423-1.32 0.316 0.814 0.514-1.29 0.379 FALSE FALSE FALSE FALSE Both 383 3827 GRCh37/hg19 s=0.2;Lambda=0.03793 2020-06-08 prsweb-phecode159-2-20001-1019-p-5e-05-mgi-20200608 prsweb-phecode159-2-20001-1019-p-5e-05-mgi-20200608 PRSWEB_PHECODE159.2_20001-1019_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE159.2_20001-1019_P_5e-05_MGI_20200608 159.2 Cancer code, self-reported: small intestine/small bowel cancer Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 59 0.51 0.000514694 0.0826 0.501 0.435-0.568 OR 4.18 1.11-15.8 4.18 1.11-15.8 3.68 1.32-10.3 3.68 1.32-10.3 2.31 1.05-5.08 2.31 1.05-5.08 1.27 0.623-2.6 1.27 0.623-2.6 1.1 0.649-1.86 1.1 0.649-1.86 1.57 0.809-3.04 0.183 0.971 0.479-1.97 0.936 1.32 0.677-2.58 0.414 FALSE FALSE FALSE FALSE Both 75 750 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode159-2-c17-p-5e-05-mgi-20200608 prsweb-phecode159-2-c17-p-5e-05-mgi-20200608 PRSWEB_PHECODE159.2_C17_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE159.2_C17_P_5e-05_MGI_20200608 159.2 Diagnoses - main ICD10: C17 Malignant neoplasm of small intestine Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 41 0.63 8.83575e-07 0.0826 0.507 0.446-0.568 OR 1.73 0.276-10.8 1.73 0.276-10.8 1.62 0.405-6.48 1.62 0.405-6.48 1.45 0.573-3.69 1.45 0.573-3.69 0.84 0.366-1.93 0.84 0.366-1.93 0.827 0.47-1.45 0.827 0.47-1.45 1.1 0.566-2.14 0.778 1.32 0.695-2.52 0.393 0.965 0.485-1.92 0.92 FALSE FALSE FALSE FALSE Both 75 750 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode159-2-c3-small-intestine-p-5e-05-mgi-20200608 prsweb-phecode159-2-c3-small-intestine-p-5e-05-mgi-20200608 PRSWEB_PHECODE159.2_C3-SMALL-INTESTINE_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE159.2_C3-SMALL-INTESTINE_P_5e-05_MGI_20200608 159.2 Malignant neoplasm of small intestine Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 51 0.97 0.000131059 0.0827 0.508 0.44-0.577 OR 0 0-0 0 0-0 0.306 0.0175-5.38 0.306 0.0175-5.38 1.15 0.422-3.14 1.15 0.422-3.14 0.972 0.444-2.13 0.972 0.444-2.13 1.25 0.749-2.09 1.25 0.749-2.09 0.526 0.255-1.08 0.081 0.991 0.53-1.85 0.977 1.04 0.561-1.91 0.911 FALSE FALSE FALSE FALSE Both 75 750 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode159-2-ukbb-saige-hrc-x159-2-p-5e-05-mgi-20200608 prsweb-phecode159-2-ukbb-saige-hrc-x159-2-p-5e-05-mgi-20200608 PRSWEB_PHECODE159.2_UKBB-SAIGE-HRC-X159.2_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE159.2_UKBB-SAIGE-HRC-X159.2_P_5e-05_MGI_20200608 159.2 Malignant neoplasm of small intestine, including duodenum Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 90 0.92 0.00403767 0.0826 0.503 0.435-0.574 OR 1.71 0.27-10.8 1.71 0.27-10.8 0.938 0.167-5.29 0.938 0.167-5.29 0.629 0.172-2.3 0.629 0.172-2.3 1.44 0.72-2.88 1.44 0.72-2.88 1.34 0.805-2.22 1.34 0.805-2.22 0.651 0.325-1.31 0.227 0.908 0.478-1.73 0.768 1.07 0.581-1.97 0.826 FALSE FALSE FALSE FALSE Both 75 750 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode159-2-20001-1019-p-5e-06-mgi-20200608 prsweb-phecode159-2-20001-1019-p-5e-06-mgi-20200608 PRSWEB_PHECODE159.2_20001-1019_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE159.2_20001-1019_P_5e-06_MGI_20200608 159.2 Cancer code, self-reported: small intestine/small bowel cancer Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 11 0.31 0.00790327 0.0825 0.518 0.445-0.597 OR 5.41 1.6-18.3 5.41 1.6-18.3 2.95 0.984-8.87 2.95 0.984-8.87 2.33 1.06-5.12 2.33 1.06-5.12 2.27 1.24-4.15 2.27 1.24-4.15 1.5 0.912-2.47 1.5 0.912-2.47 0.685 0.343-1.37 0.283 0.722 0.37-1.41 0.339 1.2 0.658-2.2 0.548 FALSE FALSE FALSE FALSE Both 75 750 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode159-2-c3-small-intestine-p-5e-06-mgi-20200608 prsweb-phecode159-2-c3-small-intestine-p-5e-06-mgi-20200608 PRSWEB_PHECODE159.2_C3-SMALL-INTESTINE_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE159.2_C3-SMALL-INTESTINE_P_5e-06_MGI_20200608 159.2 Malignant neoplasm of small intestine Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 7 0.087 0.000191755 0.0824 0.549 0.478-0.616 OR 0 0-0 0 0-0 0.981 0.177-5.43 0.981 0.177-5.43 2.33 1.06-5.11 2.33 1.06-5.11 1.59 0.818-3.11 1.59 0.818-3.11 1.33 0.799-2.21 1.33 0.799-2.21 1.13 0.553-2.32 0.734 1.58 0.803-3.13 0.185 1.56 0.795-3.06 0.196 FALSE FALSE FALSE FALSE Both 75 750 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode159-2-ukbb-saige-hrc-x159-2-p-5e-06-mgi-20200608 prsweb-phecode159-2-ukbb-saige-hrc-x159-2-p-5e-06-mgi-20200608 PRSWEB_PHECODE159.2_UKBB-SAIGE-HRC-X159.2_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE159.2_UKBB-SAIGE-HRC-X159.2_P_5e-06_MGI_20200608 159.2 Malignant neoplasm of small intestine, including duodenum Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 10 0.34 0.000155551 0.0826 0.512 0.45-0.579 OR 0 0-0 0 0-0 0.309 0.0174-5.49 0.309 0.0174-5.49 2.05 0.896-4.68 2.05 0.896-4.68 1.96 1.03-3.7 1.96 1.03-3.7 1.33 0.804-2.22 1.33 0.804-2.22 1.31 0.667-2.58 0.432 1.07 0.526-2.18 0.853 1.55 0.801-3 0.193 FALSE FALSE FALSE FALSE Both 75 750 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode159-2-20001-1019-pt-mgi-20200608 prsweb-phecode159-2-20001-1019-pt-mgi-20200608 PRSWEB_PHECODE159.2_20001-1019_PT_MGI_20200608 P&T PRSWEB_PHECODE159.2_20001-1019_PT_MGI_20200608 159.2 Cancer code, self-reported: small intestine/small bowel cancer Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative P&T UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 11 0.31 0.00790327 0.0825 0.518 0.445-0.597 OR 5.41 1.6-18.3 5.41 1.6-18.3 2.95 0.984-8.87 2.95 0.984-8.87 2.33 1.06-5.12 2.33 1.06-5.12 2.27 1.24-4.15 2.27 1.24-4.15 1.5 0.912-2.47 1.5 0.912-2.47 0.685 0.343-1.37 0.283 0.722 0.37-1.41 0.339 1.2 0.658-2.2 0.548 FALSE FALSE FALSE FALSE Both 75 750 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode159-2-c3-small-intestine-pt-mgi-20200608 prsweb-phecode159-2-c3-small-intestine-pt-mgi-20200608 PRSWEB_PHECODE159.2_C3-SMALL-INTESTINE_PT_MGI_20200608 P&T PRSWEB_PHECODE159.2_C3-SMALL-INTESTINE_PT_MGI_20200608 159.2 Malignant neoplasm of small intestine Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative P&T UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 25 0.23 0.00238821 0.0825 0.534 0.468-0.602 OR 1.73 0.277-10.8 1.73 0.277-10.8 0.957 0.172-5.33 0.957 0.172-5.33 1.16 0.425-3.18 1.16 0.425-3.18 1.43 0.717-2.85 1.43 0.717-2.85 1.11 0.653-1.87 1.11 0.653-1.87 1.49 0.731-3.03 0.273 1.8 0.908-3.58 0.0919 1.56 0.776-3.14 0.212 FALSE FALSE FALSE FALSE Both 75 750 GRCh37/hg19 P<=2e-05 2020-06-08 prsweb-phecode159-2-ukbb-saige-hrc-x159-2-pt-mgi-20200608 prsweb-phecode159-2-ukbb-saige-hrc-x159-2-pt-mgi-20200608 PRSWEB_PHECODE159.2_UKBB-SAIGE-HRC-X159.2_PT_MGI_20200608 P&T PRSWEB_PHECODE159.2_UKBB-SAIGE-HRC-X159.2_PT_MGI_20200608 159.2 Malignant neoplasm of small intestine, including duodenum Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative P&T UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 73 0.91 0.0049134 0.0826 0.504 0.432-0.577 OR 1.73 0.273-11 1.73 0.273-11 0.934 0.166-5.26 0.934 0.166-5.26 0.893 0.292-2.73 0.893 0.292-2.73 1.13 0.534-2.38 1.13 0.534-2.38 1.1 0.65-1.87 1.1 0.65-1.87 0.724 0.364-1.44 0.357 0.974 0.516-1.84 0.936 0.97 0.517-1.82 0.925 FALSE FALSE FALSE FALSE Both 75 750 GRCh37/hg19 P<=3.98e-05 2020-06-08 prsweb-phecode159-2-c17-prs-cs-mgi-20200608 prsweb-phecode159-2-c17-prs-cs-mgi-20200608 PRSWEB_PHECODE159.2_C17_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE159.2_C17_PRS-CS_MGI_20200608 159.2 Diagnoses - main ICD10: C17 Malignant neoplasm of small intestine Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative PRS-CS UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 903170 0.65 0.00226702 0.0826 0.509 0.44-0.581 OR 1.79 0.285-11.3 1.79 0.285-11.3 1.63 0.411-6.45 1.63 0.411-6.45 0.892 0.292-2.73 0.892 0.292-2.73 1.43 0.716-2.85 1.43 0.716-2.85 1.1 0.65-1.88 1.1 0.65-1.88 1.13 0.598-2.12 0.713 0.821 0.415-1.62 0.571 1.12 0.587-2.15 0.726 FALSE FALSE FALSE FALSE Both 75 750 GRCh37/hg19 auto 2020-06-08 prsweb-phecode159-2-ukbb-saige-hrc-x159-2-prs-cs-mgi-20200608 prsweb-phecode159-2-ukbb-saige-hrc-x159-2-prs-cs-mgi-20200608 PRSWEB_PHECODE159.2_UKBB-SAIGE-HRC-X159.2_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE159.2_UKBB-SAIGE-HRC-X159.2_PRS-CS_MGI_20200608 159.2 Malignant neoplasm of small intestine, including duodenum Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative PRS-CS UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1119238 0.87 2.70225e-05 0.0826 0.493 0.428-0.561 OR 2.96 0.656-13.4 2.96 0.656-13.4 2.29 0.675-7.73 2.29 0.675-7.73 2.02 0.884-4.6 2.02 0.884-4.6 0.978 0.445-2.15 0.978 0.445-2.15 1.17 0.698-1.98 1.17 0.698-1.98 1.56 0.822-2.95 0.174 0.725 0.341-1.54 0.402 1.29 0.665-2.51 0.45 FALSE FALSE FALSE FALSE Both 75 750 GRCh37/hg19 auto 2020-06-08 prsweb-phecode159-2-20001-1019-lassosum-mgi-20200608 prsweb-phecode159-2-20001-1019-lassosum-mgi-20200608 PRSWEB_PHECODE159.2_20001-1019_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE159.2_20001-1019_LASSOSUM_MGI_20200608 159.2 Cancer code, self-reported: small intestine/small bowel cancer Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative lassosum UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1487304 0.066 0.00540912 0.0824 0.574 0.515-0.64 OR 0 0-0 0 0-0 0.316 0.0182-5.49 0.316 0.0182-5.49 0.631 0.172-2.31 0.631 0.172-2.31 1.13 0.534-2.39 1.13 0.534-2.39 1.18 0.7-1.98 1.18 0.7-1.98 1.73 0.803-3.75 0.161 2.56 1.24-5.3 0.0112 2.02 0.968-4.23 0.0611 FALSE FALSE FALSE FALSE Both 75 750 GRCh37/hg19 s=0.2;Lambda=0.004281 2020-06-08 prsweb-phecode159-2-c3-small-intestine-lassosum-mgi-20200608 prsweb-phecode159-2-c3-small-intestine-lassosum-mgi-20200608 PRSWEB_PHECODE159.2_C3-SMALL-INTESTINE_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE159.2_C3-SMALL-INTESTINE_LASSOSUM_MGI_20200608 159.2 Malignant neoplasm of small intestine Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative lassosum UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 2552539 0.92 0.00689325 0.0826 0.504 0.442-0.569 OR 0 0-0 0 0-0 0.309 0.0175-5.44 0.309 0.0175-5.44 0.122 0.00759-1.96 0.122 0.00759-1.96 0.431 0.145-1.28 0.431 0.145-1.28 1.03 0.603-1.75 1.03 0.603-1.75 1.01 0.53-1.94 0.969 0.896 0.462-1.74 0.745 1 0.525-1.92 0.99 FALSE FALSE FALSE FALSE Both 75 750 GRCh37/hg19 s=0.2;Lambda=0.001 2020-06-08 prsweb-phecode159-3-ukbb-saige-hrc-x159-3-p-5e-05-mgi-20200608 prsweb-phecode159-3-ukbb-saige-hrc-x159-3-p-5e-05-mgi-20200608 PRSWEB_PHECODE159.3_UKBB-SAIGE-HRC-X159.3_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE159.3_UKBB-SAIGE-HRC-X159.3_P_5e-05_MGI_20200608 159.3 Malignant neoplasm of gallbladder and extrahepatic bile ducts Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 84 0.25 0.0192048 0.0824 0.526 0.454-0.601 OR 2.88 0.632-13.2 2.88 0.632-13.2 2.3 0.675-7.87 2.3 0.675-7.87 1.24 0.447-3.41 1.24 0.447-3.41 1.37 0.665-2.83 1.37 0.665-2.83 1.18 0.694-2.02 1.18 0.694-2.02 1.04 0.525-2.05 0.913 1.16 0.592-2.28 0.664 1.26 0.649-2.47 0.491 FALSE FALSE FALSE FALSE Both 72 720 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode159-3-ukbb-saige-hrc-x159-3-p-5e-06-mgi-20200608 prsweb-phecode159-3-ukbb-saige-hrc-x159-3-p-5e-06-mgi-20200608 PRSWEB_PHECODE159.3_UKBB-SAIGE-HRC-X159.3_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE159.3_UKBB-SAIGE-HRC-X159.3_P_5e-06_MGI_20200608 159.3 Malignant neoplasm of gallbladder and extrahepatic bile ducts Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 8 0.6 0.0168548 0.0826 0.483 0.417-0.549 OR 0 0-0 0 0-0 1.01 0.179-5.7 1.01 0.179-5.7 1.58 0.62-4.04 1.58 0.62-4.04 1.35 0.658-2.79 1.35 0.658-2.79 1.03 0.595-1.78 1.03 0.595-1.78 1.44 0.721-2.86 0.303 1.27 0.631-2.55 0.504 1.27 0.63-2.57 0.503 FALSE FALSE FALSE FALSE Both 72 720 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode159-3-ukbb-saige-hrc-x159-3-pt-mgi-20200608 prsweb-phecode159-3-ukbb-saige-hrc-x159-3-pt-mgi-20200608 PRSWEB_PHECODE159.3_UKBB-SAIGE-HRC-X159.3_PT_MGI_20200608 P&T PRSWEB_PHECODE159.3_UKBB-SAIGE-HRC-X159.3_PT_MGI_20200608 159.3 Malignant neoplasm of gallbladder and extrahepatic bile ducts Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative P&T UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 114 0.62 0.0361905 0.0826 0.502 0.43-0.573 OR 1.89 0.3-11.9 1.89 0.3-11.9 1.01 0.178-5.77 1.01 0.178-5.77 1.55 0.608-3.96 1.55 0.608-3.96 1.36 0.658-2.79 1.36 0.658-2.79 0.958 0.548-1.68 0.958 0.548-1.68 1.5 0.775-2.9 0.229 1.06 0.52-2.15 0.878 1.13 0.561-2.28 0.729 FALSE FALSE FALSE FALSE Both 72 720 GRCh37/hg19 P<=6.31e-05 2020-06-08 prsweb-phecode159-3-ukbb-saige-hrc-x159-3-prs-cs-mgi-20200608 prsweb-phecode159-3-ukbb-saige-hrc-x159-3-prs-cs-mgi-20200608 PRSWEB_PHECODE159.3_UKBB-SAIGE-HRC-X159.3_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE159.3_UKBB-SAIGE-HRC-X159.3_PRS-CS_MGI_20200608 159.3 Malignant neoplasm of gallbladder and extrahepatic bile ducts Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative PRS-CS UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1119238 0.38 0.00268887 0.0825 0.529 0.454-0.599 OR 5.32 1.56-18.2 5.32 1.56-18.2 2.88 0.948-8.78 2.88 0.948-8.78 1.19 0.429-3.27 1.19 0.429-3.27 1.33 0.643-2.74 1.33 0.643-2.74 1.49 0.896-2.48 1.49 0.896-2.48 0.785 0.389-1.58 0.498 0.915 0.465-1.8 0.797 1.19 0.63-2.25 0.59 FALSE FALSE FALSE FALSE Both 72 720 GRCh37/hg19 auto 2020-06-08 prsweb-phecode159-3-ukbb-saige-hrc-x159-3-lassosum-mgi-20200608 prsweb-phecode159-3-ukbb-saige-hrc-x159-3-lassosum-mgi-20200608 PRSWEB_PHECODE159.3_UKBB-SAIGE-HRC-X159.3_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE159.3_UKBB-SAIGE-HRC-X159.3_LASSOSUM_MGI_20200608 159.3 Malignant neoplasm of gallbladder and extrahepatic bile ducts Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative lassosum UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 177340 0.6 0.0285237 0.0826 0.523 0.45-0.595 OR 2.96 0.66-13.3 2.96 0.66-13.3 1.64 0.41-6.6 1.64 0.41-6.6 1.24 0.451-3.42 1.24 0.451-3.42 1.04 0.474-2.29 1.04 0.474-2.29 1.41 0.844-2.36 1.41 0.844-2.36 0.947 0.476-1.88 0.877 0.876 0.435-1.76 0.712 1.29 0.678-2.45 0.438 FALSE FALSE FALSE FALSE Both 72 720 GRCh37/hg19 s=1;Lambda=0.07848 2020-06-08 prsweb-phecode159-4-ukbb-saige-hrc-x159-4-p-5e-06-mgi-20200608 prsweb-phecode159-4-ukbb-saige-hrc-x159-4-p-5e-06-mgi-20200608 PRSWEB_PHECODE159.4_UKBB-SAIGE-HRC-X159.4_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE159.4_UKBB-SAIGE-HRC-X159.4_P_5e-06_MGI_20200608 159.4 Malignant neoplasm of retroperitoneum and peritoneum Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 9 0.96 0.000598059 0.0826 0.466 0.415-0.515 OR 1.06 0.185-6.12 1.06 0.185-6.12 1.67 0.597-4.68 1.67 0.597-4.68 0.821 0.338-1.99 0.821 0.338-1.99 1.56 0.935-2.61 1.56 0.935-2.61 1.07 0.713-1.61 1.07 0.713-1.61 1.54 0.939-2.54 0.0868 0.996 0.581-1.71 0.989 1.26 0.752-2.13 0.377 FALSE FALSE FALSE FALSE Both 130 1300 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode159-4-c48-prs-cs-mgi-20200608 prsweb-phecode159-4-c48-prs-cs-mgi-20200608 PRSWEB_PHECODE159.4_C48_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE159.4_C48_PRS-CS_MGI_20200608 159.4 Diagnoses - main ICD10: C48 Malignant neoplasm of retroperitoneum and peritoneum Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative PRS-CS UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 906432 0.1 2.53689e-05 0.0825 0.544 0.49-0.598 OR 1.1 0.191-6.32 1.1 0.191-6.32 0.936 0.25-3.51 0.936 0.25-3.51 1.64 0.83-3.22 1.64 0.83-3.22 1.38 0.808-2.35 1.38 0.808-2.35 1.4 0.947-2.06 1.4 0.947-2.06 1.6 0.949-2.71 0.0775 1.15 0.659-2 0.625 1.71 1.02-2.88 0.041 FALSE FALSE FALSE FALSE Both 130 1300 GRCh37/hg19 auto 2020-06-08 prsweb-phecode159-4-ukbb-saige-hrc-x159-4-prs-cs-mgi-20200608 prsweb-phecode159-4-ukbb-saige-hrc-x159-4-prs-cs-mgi-20200608 PRSWEB_PHECODE159.4_UKBB-SAIGE-HRC-X159.4_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE159.4_UKBB-SAIGE-HRC-X159.4_PRS-CS_MGI_20200608 159.4 Malignant neoplasm of retroperitoneum and peritoneum Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative PRS-CS UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1119238 0.91 7.50336e-05 0.0826 0.513 0.454-0.568 OR 0 0-0 0 0-0 0.939 0.25-3.53 0.939 0.25-3.53 0.987 0.431-2.26 0.987 0.431-2.26 0.944 0.513-1.73 0.944 0.513-1.73 1.16 0.777-1.73 1.16 0.777-1.73 0.896 0.534-1.5 0.678 1.02 0.616-1.67 0.951 1.12 0.682-1.82 0.663 FALSE FALSE FALSE FALSE Both 130 1300 GRCh37/hg19 auto 2020-06-08 prsweb-phecode159-4-c48-lassosum-mgi-20200608 prsweb-phecode159-4-c48-lassosum-mgi-20200608 PRSWEB_PHECODE159.4_C48_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE159.4_C48_LASSOSUM_MGI_20200608 159.4 Diagnoses - main ICD10: C48 Malignant neoplasm of retroperitoneum and peritoneum Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative lassosum UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 276551 0.21 0.00282013 0.0825 0.532 0.479-0.587 OR 1.09 0.19-6.3 1.09 0.19-6.3 0.939 0.25-3.53 0.939 0.25-3.53 1.15 0.527-2.49 1.15 0.527-2.49 0.86 0.459-1.61 0.86 0.459-1.61 1.34 0.911-1.98 1.34 0.911-1.98 1.21 0.722-2.01 0.475 0.999 0.586-1.7 0.997 1.51 0.913-2.5 0.108 FALSE FALSE FALSE FALSE Both 130 1300 GRCh37/hg19 s=0.9;Lambda=0.06158 2020-06-08 prsweb-phecode165-c3-respiratory-intrathoracic-p-5e-05-mgi-20200608 prsweb-phecode165-c3-respiratory-intrathoracic-p-5e-05-mgi-20200608 PRSWEB_PHECODE165_C3-RESPIRATORY-INTRATHORACIC_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE165_C3-RESPIRATORY-INTRATHORACIC_P_5e-05_MGI_20200608 165 Malignant neoplasm of respiratory system and intrathoracic organs Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 136 0.14 0.00145626 0.0827 0.515 0.489-0.541 OR 0.504 0.14-1.82 0.504 0.14-1.82 0.46 0.177-1.19 0.46 0.177-1.19 1.02 0.667-1.57 1.02 0.667-1.57 1.16 0.86-1.56 1.16 0.86-1.56 1.27 1.03-1.56 1.27 1.03-1.56 1.14 0.869-1.49 0.346 0.967 0.732-1.28 0.817 1.3 1-1.69 0.0503 FALSE FALSE FALSE FALSE Both 475 4743 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode165-ukbb-saige-hrc-x165-p-5e-05-mgi-20200608 prsweb-phecode165-ukbb-saige-hrc-x165-p-5e-05-mgi-20200608 PRSWEB_PHECODE165_UKBB-SAIGE-HRC-X165_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE165_UKBB-SAIGE-HRC-X165_P_5e-05_MGI_20200608 165 Cancer within the respiratory system Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 103 0.32 4.11883e-05 0.0827 0.505 0.479-0.532 OR 1.74 0.83-3.65 1.74 0.83-3.65 1.52 0.865-2.66 1.52 0.865-2.66 1.2 0.804-1.79 1.2 0.804-1.79 1.18 0.881-1.59 1.18 0.881-1.59 1.09 0.879-1.35 1.09 0.879-1.35 1.01 0.774-1.31 0.949 0.94 0.717-1.23 0.654 1.07 0.819-1.39 0.637 FALSE FALSE FALSE FALSE Both 475 4743 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode165-c3-respiratory-intrathoracic-p-5e-06-mgi-20200608 prsweb-phecode165-c3-respiratory-intrathoracic-p-5e-06-mgi-20200608 PRSWEB_PHECODE165_C3-RESPIRATORY-INTRATHORACIC_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE165_C3-RESPIRATORY-INTRATHORACIC_P_5e-06_MGI_20200608 165 Malignant neoplasm of respiratory system and intrathoracic organs Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 27 0.72 2.25885e-05 0.0827 0.492 0.465-0.518 OR 0.511 0.141-1.85 0.511 0.141-1.85 0.671 0.301-1.5 0.671 0.301-1.5 0.852 0.537-1.35 0.852 0.537-1.35 1.02 0.747-1.39 1.02 0.747-1.39 0.951 0.763-1.18 0.951 0.763-1.18 0.85 0.648-1.12 0.242 1.1 0.854-1.43 0.452 0.933 0.715-1.22 0.61 FALSE FALSE FALSE FALSE Both 475 4743 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode165-ukbb-saige-hrc-x165-p-5e-06-mgi-20200608 prsweb-phecode165-ukbb-saige-hrc-x165-p-5e-06-mgi-20200608 PRSWEB_PHECODE165_UKBB-SAIGE-HRC-X165_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE165_UKBB-SAIGE-HRC-X165_P_5e-06_MGI_20200608 165 Cancer within the respiratory system Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 18 0.34 1.5221e-05 0.0827 0.503 0.477-0.532 OR 1.12 0.46-2.75 1.12 0.46-2.75 0.888 0.437-1.81 0.888 0.437-1.81 1.12 0.74-1.69 1.12 0.74-1.69 1.21 0.904-1.62 1.21 0.904-1.62 1.11 0.896-1.37 1.11 0.896-1.37 1.18 0.905-1.54 0.22 1.01 0.764-1.33 0.959 1.17 0.897-1.53 0.247 FALSE FALSE FALSE FALSE Both 475 4743 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode165-c3-respiratory-intrathoracic-p-5e-07-mgi-20200608 prsweb-phecode165-c3-respiratory-intrathoracic-p-5e-07-mgi-20200608 PRSWEB_PHECODE165_C3-RESPIRATORY-INTRATHORACIC_P_5e-07_MGI_20200608 P_5e-07 PRSWEB_PHECODE165_C3-RESPIRATORY-INTRATHORACIC_P_5e-07_MGI_20200608 165 Malignant neoplasm of respiratory system and intrathoracic organs Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-07) UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 9 0.6 0.000624929 0.0827 0.48 0.454-0.505 OR 1.11 0.453-2.71 1.11 0.453-2.71 1.29 0.706-2.34 1.29 0.706-2.34 1.14 0.761-1.72 1.14 0.761-1.72 1.04 0.762-1.41 1.04 0.762-1.41 1.09 0.883-1.35 1.09 0.883-1.35 1.08 0.829-1.4 0.579 0.914 0.692-1.21 0.526 1.1 0.844-1.43 0.485 FALSE FALSE FALSE FALSE Both 475 4743 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode165-ukbb-saige-hrc-x165-p-5e-07-mgi-20200608 prsweb-phecode165-ukbb-saige-hrc-x165-p-5e-07-mgi-20200608 PRSWEB_PHECODE165_UKBB-SAIGE-HRC-X165_P_5e-07_MGI_20200608 P_5e-07 PRSWEB_PHECODE165_UKBB-SAIGE-HRC-X165_P_5e-07_MGI_20200608 165 Cancer within the respiratory system Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative Fixed threshold (5e-07) UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 5 0.44 4.22101e-05 0.0827 0.505 0.477-0.532 OR 1.37 0.595-3.14 1.37 0.595-3.14 1.11 0.579-2.11 1.11 0.579-2.11 1.2 0.807-1.8 1.2 0.807-1.8 1.28 0.961-1.71 1.28 0.961-1.71 1.11 0.896-1.37 1.11 0.896-1.37 1.11 0.851-1.45 0.443 0.962 0.731-1.27 0.781 1.13 0.87-1.48 0.351 FALSE FALSE FALSE FALSE Both 475 4743 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode165-c3-mesothelioma-pt-mgi-20200608 prsweb-phecode165-c3-mesothelioma-pt-mgi-20200608 PRSWEB_PHECODE165_C3-MESOTHELIOMA_PT_MGI_20200608 P&T PRSWEB_PHECODE165_C3-MESOTHELIOMA_PT_MGI_20200608 165 Mesothelioma Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative P&T UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 18 0.98 0.00054416 0.0827 0.497 0.47-0.526 OR 1.34 0.582-3.07 1.34 0.582-3.07 0.88 0.433-1.79 0.88 0.433-1.79 0.974 0.631-1.5 0.974 0.631-1.5 1.18 0.879-1.59 1.18 0.879-1.59 1.07 0.866-1.33 1.07 0.866-1.33 1.11 0.852-1.45 0.432 1.02 0.775-1.33 0.907 1.11 0.849-1.45 0.451 FALSE FALSE FALSE FALSE Both 475 4743 GRCh37/hg19 P<=1e-05 2020-06-08 prsweb-phecode165-c3-respiratory-intrathoracic-pt-mgi-20200608 prsweb-phecode165-c3-respiratory-intrathoracic-pt-mgi-20200608 PRSWEB_PHECODE165_C3-RESPIRATORY-INTRATHORACIC_PT_MGI_20200608 P&T PRSWEB_PHECODE165_C3-RESPIRATORY-INTRATHORACIC_PT_MGI_20200608 165 Malignant neoplasm of respiratory system and intrathoracic organs Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative P&T UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 136 0.14 0.00145626 0.0827 0.515 0.489-0.541 OR 0.504 0.14-1.82 0.504 0.14-1.82 0.46 0.177-1.19 0.46 0.177-1.19 1.02 0.667-1.57 1.02 0.667-1.57 1.16 0.86-1.56 1.16 0.86-1.56 1.27 1.03-1.56 1.27 1.03-1.56 1.14 0.869-1.49 0.346 0.967 0.732-1.28 0.817 1.3 1-1.69 0.0503 FALSE FALSE FALSE FALSE Both 475 4743 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode165-ukbb-saige-hrc-x165-pt-mgi-20200608 prsweb-phecode165-ukbb-saige-hrc-x165-pt-mgi-20200608 PRSWEB_PHECODE165_UKBB-SAIGE-HRC-X165_PT_MGI_20200608 P&T PRSWEB_PHECODE165_UKBB-SAIGE-HRC-X165_PT_MGI_20200608 165 Cancer within the respiratory system Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative P&T UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 46 0.21 0.000174384 0.0827 0.508 0.482-0.537 OR 1.34 0.584-3.08 1.34 0.584-3.08 1.09 0.573-2.09 1.09 0.573-2.09 1.02 0.667-1.57 1.02 0.667-1.57 1.25 0.939-1.67 1.25 0.939-1.67 1.05 0.848-1.3 1.05 0.848-1.3 1.07 0.82-1.4 0.616 1.03 0.788-1.35 0.821 1.09 0.834-1.42 0.536 FALSE FALSE FALSE FALSE Both 475 4743 GRCh37/hg19 P<=2e-05 2020-06-08 prsweb-phecode165-c3-mesothelioma-prs-cs-mgi-20200608 prsweb-phecode165-c3-mesothelioma-prs-cs-mgi-20200608 PRSWEB_PHECODE165_C3-MESOTHELIOMA_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE165_C3-MESOTHELIOMA_PRS-CS_MGI_20200608 165 Mesothelioma Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative PRS-CS UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 938343 0.16 0.00111442 0.0827 0.518 0.49-0.546 OR 1.14 0.466-2.79 1.14 0.466-2.79 1.21 0.653-2.26 1.21 0.653-2.26 1.21 0.813-1.81 1.21 0.813-1.81 1.19 0.887-1.6 1.19 0.887-1.6 1.12 0.902-1.38 1.12 0.902-1.38 0.944 0.718-1.24 0.678 1.08 0.827-1.41 0.579 1.13 0.871-1.48 0.351 FALSE FALSE FALSE FALSE Both 475 4743 GRCh37/hg19 auto 2020-06-08 prsweb-phecode165-c3-respiratory-intrathoracic-prs-cs-mgi-20200608 prsweb-phecode165-c3-respiratory-intrathoracic-prs-cs-mgi-20200608 PRSWEB_PHECODE165_C3-RESPIRATORY-INTRATHORACIC_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE165_C3-RESPIRATORY-INTRATHORACIC_PRS-CS_MGI_20200608 165 Malignant neoplasm of respiratory system and intrathoracic organs Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative PRS-CS UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1110227 0.19 0.000189358 0.0827 0.52 0.493-0.547 OR 1.78 0.848-3.73 1.78 0.848-3.73 1.44 0.805-2.57 1.44 0.805-2.57 0.766 0.473-1.24 0.766 0.473-1.24 0.817 0.582-1.15 0.817 0.582-1.15 1.01 0.812-1.26 1.01 0.812-1.26 1.07 0.813-1.42 0.617 1.36 1.05-1.78 0.0218 1.15 0.876-1.52 0.308 FALSE FALSE FALSE FALSE Both 475 4743 GRCh37/hg19 auto 2020-06-08 prsweb-phecode165-c45-prs-cs-mgi-20200608 prsweb-phecode165-c45-prs-cs-mgi-20200608 PRSWEB_PHECODE165_C45_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE165_C45_PRS-CS_MGI_20200608 165 Diagnoses - main ICD10: C45 Mesothelioma Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative PRS-CS UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 934591 0.35 0.00115817 0.0827 0.511 0.485-0.54 OR 1.56 0.713-3.4 1.56 0.713-3.4 1.64 0.95-2.84 1.64 0.95-2.84 0.986 0.639-1.52 0.986 0.639-1.52 1.12 0.826-1.51 1.12 0.826-1.51 0.996 0.801-1.24 0.996 0.801-1.24 1.18 0.898-1.55 0.237 1.25 0.958-1.64 0.1 1.14 0.867-1.5 0.344 FALSE FALSE FALSE FALSE Both 475 4743 GRCh37/hg19 auto 2020-06-08 prsweb-phecode165-ukbb-saige-hrc-x165-prs-cs-mgi-20200608 prsweb-phecode165-ukbb-saige-hrc-x165-prs-cs-mgi-20200608 PRSWEB_PHECODE165_UKBB-SAIGE-HRC-X165_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE165_UKBB-SAIGE-HRC-X165_PRS-CS_MGI_20200608 165 Cancer within the respiratory system Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative PRS-CS UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1119238 0.057 0.00198538 0.0826 0.527 0.499-0.553 OR 0.718 0.24-2.15 0.718 0.24-2.15 0.889 0.437-1.81 0.889 0.437-1.81 1.21 0.813-1.81 1.21 0.813-1.81 1.27 0.948-1.69 1.27 0.948-1.69 1.33 1.09-1.64 1.33 1.09-1.64 1.12 0.851-1.47 0.421 1.01 0.767-1.34 0.917 1.38 1.06-1.79 0.017 FALSE FALSE FALSE FALSE Both 475 4743 GRCh37/hg19 auto 2020-06-08 prsweb-phecode165-c3-mesothelioma-lassosum-mgi-20200608 prsweb-phecode165-c3-mesothelioma-lassosum-mgi-20200608 PRSWEB_PHECODE165_C3-MESOTHELIOMA_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE165_C3-MESOTHELIOMA_LASSOSUM_MGI_20200608 165 Mesothelioma Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative lassosum UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 3382118 0.14 0.00210676 0.0827 0.519 0.493-0.547 OR 1.14 0.466-2.79 1.14 0.466-2.79 0.992 0.505-1.95 0.992 0.505-1.95 1.12 0.74-1.69 1.12 0.74-1.69 1.24 0.928-1.66 1.24 0.928-1.66 1.1 0.892-1.37 1.1 0.892-1.37 1.01 0.767-1.32 0.953 1.11 0.853-1.46 0.426 1.16 0.887-1.51 0.282 FALSE FALSE FALSE FALSE Both 475 4743 GRCh37/hg19 s=1;Lambda=0.001 2020-06-08 prsweb-phecode165-c3-respiratory-intrathoracic-lassosum-mgi-20200608 prsweb-phecode165-c3-respiratory-intrathoracic-lassosum-mgi-20200608 PRSWEB_PHECODE165_C3-RESPIRATORY-INTRATHORACIC_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE165_C3-RESPIRATORY-INTRATHORACIC_LASSOSUM_MGI_20200608 165 Malignant neoplasm of respiratory system and intrathoracic organs Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative lassosum UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1898 0.12 0.00116527 0.0827 0.523 0.495-0.549 OR 0.927 0.349-2.47 0.927 0.349-2.47 0.895 0.44-1.82 0.895 0.44-1.82 1.07 0.705-1.63 1.07 0.705-1.63 1.02 0.746-1.39 1.02 0.746-1.39 1.08 0.87-1.33 1.08 0.87-1.33 1.11 0.842-1.47 0.452 1.34 1.03-1.75 0.0321 1.24 0.946-1.63 0.119 FALSE FALSE FALSE FALSE Both 475 4743 GRCh37/hg19 s=0.2;Lambda=0.03793 2020-06-08 prsweb-phecode165-c45-lassosum-mgi-20200608 prsweb-phecode165-c45-lassosum-mgi-20200608 PRSWEB_PHECODE165_C45_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE165_C45_LASSOSUM_MGI_20200608 165 Diagnoses - main ICD10: C45 Mesothelioma Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative lassosum UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 3360952 0.11 0.00197781 0.0827 0.52 0.495-0.548 OR 1.13 0.463-2.77 1.13 0.463-2.77 0.995 0.506-1.96 0.995 0.506-1.96 0.98 0.635-1.51 0.98 0.635-1.51 1.23 0.92-1.65 1.23 0.92-1.65 1.26 1.02-1.55 1.26 1.02-1.55 1.14 0.866-1.5 0.354 1.09 0.827-1.44 0.535 1.36 1.04-1.78 0.0233 FALSE FALSE FALSE FALSE Both 475 4743 GRCh37/hg19 s=1;Lambda=0.001 2020-06-08 prsweb-phecode165-ukbb-saige-hrc-x165-lassosum-mgi-20200608 prsweb-phecode165-ukbb-saige-hrc-x165-lassosum-mgi-20200608 PRSWEB_PHECODE165_UKBB-SAIGE-HRC-X165_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE165_UKBB-SAIGE-HRC-X165_LASSOSUM_MGI_20200608 165 Cancer within the respiratory system Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative lassosum UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 879334 0.033 0.00187058 0.0826 0.53 0.502-0.557 OR 2.22 1.12-4.37 2.22 1.12-4.37 1.65 0.956-2.86 1.65 0.956-2.86 1.3 0.879-1.92 1.3 0.879-1.92 1.14 0.848-1.54 1.14 0.848-1.54 1.2 0.97-1.48 1.2 0.97-1.48 1.06 0.802-1.4 0.682 1.23 0.934-1.61 0.142 1.3 0.992-1.69 0.0569 TRUE FALSE FALSE TRUE Both 475 4743 GRCh37/hg19 s=1;Lambda=0.01438 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000387/ScoringFiles/ phewas/PRSWEB_PHECODE165_UKBB-SAIGE-HRC-X165_LASSOSUM_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE165_UKBB-SAIGE-HRC-X165_LASSOSUM_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode165-1-20001-1001-p-5e-05-mgi-20200608 prsweb-phecode165-1-20001-1001-p-5e-05-mgi-20200608 PRSWEB_PHECODE165.1_20001-1001_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE165.1_20001-1001_P_5e-05_MGI_20200608 165.1 Cancer code, self-reported: lung cancer Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 52 0.25 0.000119035 0.0827 0.514 0.486-0.542 OR 1.01 0.376-2.7 1.01 0.376-2.7 1.18 0.615-2.27 1.18 0.615-2.27 1.23 0.809-1.86 1.23 0.809-1.86 1.03 0.746-1.43 1.03 0.746-1.43 1.25 1.01-1.56 1.25 1.01-1.56 0.897 0.673-1.2 0.459 0.934 0.703-1.24 0.64 1.19 0.905-1.56 0.216 FALSE FALSE FALSE FALSE Both 428 4270 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode165-1-22140-p-5e-05-mgi-20200608 prsweb-phecode165-1-22140-p-5e-05-mgi-20200608 PRSWEB_PHECODE165.1_22140_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE165.1_22140_P_5e-05_MGI_20200608 165.1 Doctor diagnosed lung cancer (not mesothelioma) Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 32 0.56 0.000714601 0.0828 0.504 0.475-0.532 OR 0.337 0.065-1.74 0.337 0.065-1.74 0.507 0.195-1.32 0.507 0.195-1.32 1.15 0.745-1.76 1.15 0.745-1.76 0.986 0.708-1.37 0.986 0.708-1.37 1.08 0.86-1.35 1.08 0.86-1.35 1.11 0.837-1.48 0.465 1.1 0.826-1.46 0.518 1.16 0.876-1.54 0.297 FALSE FALSE FALSE FALSE Both 428 4270 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode165-1-gwas-catalog-r2019-05-03-x165-1-p-5e-05-mgi-20200608 prsweb-phecode165-1-gwas-catalog-r2019-05-03-x165-1-p-5e-05-mgi-20200608 PRSWEB_PHECODE165.1_GWAS-Catalog-r2019-05-03-X165.1_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE165.1_GWAS-Catalog-r2019-05-03-X165.1_P_5e-05_MGI_20200608 165.1 Lung cancer in ever smokers;Squamous cell lung carcinoma;Lung adenocarcinoma;Lung cancer;Lung cancer in never smokers;Familial squamous cell lung carcinoma;Familial lung adenocarcinoma;Familial lung cancer;Small cell lung carcinoma Binary 510 unique SNPs MGI Michigan Genomics Initiative Fixed threshold (5e-05) GWAS Catalog (2019-05-03) 19836008;24880342;28604730;29924316 https://www.ncbi.nlm.nih.gov/pubmed/?term=19836008+24880342+28604730+29924316 289 0.0043 2.13894e-06 0.0826 0.534 0.504-0.561 OR 1.28 0.518-3.14 1.28 0.518-3.14 0.978 0.479-2 0.978 0.479-2 1.19 0.78-1.82 1.19 0.78-1.82 1.48 1.11-1.98 1.48 1.11-1.98 1.34 1.08-1.66 1.34 1.08-1.66 1.35 0.999-1.81 0.0504 1.29 0.957-1.74 0.094 1.62 1.22-2.16 0.000998 TRUE FALSE FALSE FALSE Both 428 4270 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode165-1-ukbb-saige-hrc-x165-1-p-5e-05-mgi-20200608 prsweb-phecode165-1-ukbb-saige-hrc-x165-1-p-5e-05-mgi-20200608 PRSWEB_PHECODE165.1_UKBB-SAIGE-HRC-X165.1_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE165.1_UKBB-SAIGE-HRC-X165.1_P_5e-05_MGI_20200608 165.1 Cancer of bronchus; lung Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 109 0.02 2.51818e-05 0.0827 0.533 0.505-0.563 OR 2.21 1.08-4.52 2.21 1.08-4.52 1.23 0.639-2.35 1.23 0.639-2.35 0.858 0.528-1.39 0.858 0.528-1.39 1.12 0.819-1.55 1.12 0.819-1.55 1.27 1.02-1.58 1.27 1.02-1.58 0.781 0.577-1.06 0.108 1.14 0.867-1.51 0.344 1.23 0.937-1.61 0.137 TRUE FALSE FALSE FALSE Both 428 4270 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode165-1-20001-1001-p-5e-06-mgi-20200608 prsweb-phecode165-1-20001-1001-p-5e-06-mgi-20200608 PRSWEB_PHECODE165.1_20001-1001_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE165.1_20001-1001_P_5e-06_MGI_20200608 165.1 Cancer code, self-reported: lung cancer Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 10 0.49 1.50466e-06 0.0828 0.492 0.463-0.519 OR 1.71 0.777-3.76 1.71 0.777-3.76 1.33 0.709-2.48 1.33 0.709-2.48 1.23 0.814-1.87 1.23 0.814-1.87 1.03 0.747-1.43 1.03 0.747-1.43 1.04 0.825-1.3 1.04 0.825-1.3 0.916 0.685-1.23 0.556 1.16 0.885-1.53 0.277 1.07 0.809-1.42 0.628 FALSE FALSE FALSE FALSE Both 428 4270 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode165-1-22140-p-5e-06-mgi-20200608 prsweb-phecode165-1-22140-p-5e-06-mgi-20200608 PRSWEB_PHECODE165.1_22140_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE165.1_22140_P_5e-06_MGI_20200608 165.1 Doctor diagnosed lung cancer (not mesothelioma) Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 5 0.82 0.00297657 0.0828 0.497 0.47-0.524 OR 0 0-0 0 0-0 0.28 0.0792-0.993 0.28 0.0792-0.993 0.706 0.418-1.19 0.706 0.418-1.19 0.964 0.69-1.35 0.964 0.69-1.35 1.12 0.896-1.4 1.12 0.896-1.4 1.22 0.921-1.61 0.165 0.991 0.74-1.33 0.952 1.19 0.898-1.58 0.227 FALSE FALSE FALSE FALSE Both 428 4270 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode165-1-gwas-catalog-r2019-05-03-x165-1-p-5e-06-mgi-20200608 prsweb-phecode165-1-gwas-catalog-r2019-05-03-x165-1-p-5e-06-mgi-20200608 PRSWEB_PHECODE165.1_GWAS-Catalog-r2019-05-03-X165.1_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE165.1_GWAS-Catalog-r2019-05-03-X165.1_P_5e-06_MGI_20200608 165.1 Lung cancer in ever smokers;Squamous cell lung carcinoma;Lung adenocarcinoma;Lung cancer;Lung cancer in never smokers;Familial squamous cell lung carcinoma;Familial lung adenocarcinoma;Familial lung cancer;Small cell lung carcinoma Binary 510 unique SNPs MGI Michigan Genomics Initiative Fixed threshold (5e-06) GWAS Catalog (2019-05-03) 19836008;24880342;28604730;29924316 https://www.ncbi.nlm.nih.gov/pubmed/?term=19836008+24880342+28604730+29924316 210 0.00068 9.54211e-05 0.0826 0.545 0.515-0.574 OR 1.05 0.391-2.8 1.05 0.391-2.8 0.748 0.334-1.67 0.748 0.334-1.67 0.95 0.597-1.51 0.95 0.597-1.51 1.45 1.08-1.94 1.45 1.08-1.94 1.44 1.17-1.79 1.44 1.17-1.79 1.35 0.994-1.83 0.0544 1.45 1.07-1.96 0.0165 1.83 1.37-2.45 4.5e-05 TRUE FALSE FALSE FALSE Both 428 4270 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode165-1-ukbb-saige-hrc-x165-1-p-5e-06-mgi-20200608 prsweb-phecode165-1-ukbb-saige-hrc-x165-1-p-5e-06-mgi-20200608 PRSWEB_PHECODE165.1_UKBB-SAIGE-HRC-X165.1_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE165.1_UKBB-SAIGE-HRC-X165.1_P_5e-06_MGI_20200608 165.1 Cancer of bronchus; lung Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 18 0.16 4.90063e-06 0.0827 0.501 0.471-0.531 OR 1.26 0.512-3.1 1.26 0.512-3.1 1.81 1.04-3.15 1.81 1.04-3.15 1.81 1.26-2.6 1.81 1.26-2.6 1.37 1.02-1.84 1.37 1.02-1.84 1.2 0.961-1.49 1.2 0.961-1.49 0.892 0.67-1.19 0.433 0.952 0.718-1.26 0.735 1.13 0.858-1.48 0.393 FALSE FALSE FALSE FALSE Both 428 4270 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode165-1-c34-p-5e-07-mgi-20200608 prsweb-phecode165-1-c34-p-5e-07-mgi-20200608 PRSWEB_PHECODE165.1_C34_P_5e-07_MGI_20200608 P_5e-07 PRSWEB_PHECODE165.1_C34_P_5e-07_MGI_20200608 165.1 Diagnoses - main ICD10: C34 Malignant neoplasm of bronchus and lung Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-07) UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 6 0.34 0.00114289 0.0828 0.486 0.46-0.513 OR 1.02 0.38-2.72 1.02 0.38-2.72 0.738 0.33-1.65 0.738 0.33-1.65 0.99 0.628-1.56 0.99 0.628-1.56 1.36 1.01-1.83 1.36 1.01-1.83 1.08 0.859-1.35 1.08 0.859-1.35 1.06 0.807-1.4 0.658 0.924 0.693-1.23 0.588 1.07 0.811-1.41 0.628 FALSE FALSE FALSE FALSE Both 428 4270 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode165-1-gwas-catalog-r2019-05-03-x165-1-p-5e-07-mgi-20200608 prsweb-phecode165-1-gwas-catalog-r2019-05-03-x165-1-p-5e-07-mgi-20200608 PRSWEB_PHECODE165.1_GWAS-Catalog-r2019-05-03-X165.1_P_5e-07_MGI_20200608 P_5e-07 PRSWEB_PHECODE165.1_GWAS-Catalog-r2019-05-03-X165.1_P_5e-07_MGI_20200608 165.1 Lung cancer in ever smokers;Squamous cell lung carcinoma;Lung adenocarcinoma;Lung cancer;Lung cancer in never smokers;Familial squamous cell lung carcinoma;Familial lung adenocarcinoma;Familial lung cancer;Small cell lung carcinoma Binary 510 unique SNPs MGI Michigan Genomics Initiative Fixed threshold (5e-07) GWAS Catalog (2019-05-03) 19836008;24880342;28604730;29924316 https://www.ncbi.nlm.nih.gov/pubmed/?term=19836008+24880342+28604730+29924316 58 0.0074 0.000134427 0.0826 0.525 0.497-0.553 OR 1.75 0.797-3.86 1.75 0.797-3.86 1.47 0.801-2.68 1.47 0.801-2.68 1.5 1.02-2.22 1.5 1.02-2.22 1.34 0.993-1.81 1.34 0.993-1.81 1.21 0.975-1.51 1.21 0.975-1.51 1.24 0.93-1.66 0.141 1.19 0.887-1.6 0.247 1.4 1.05-1.86 0.0205 TRUE FALSE FALSE FALSE Both 428 4270 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode165-1-lung-cancer-mesot-p-5e-07-mgi-20200608 prsweb-phecode165-1-lung-cancer-mesot-p-5e-07-mgi-20200608 PRSWEB_PHECODE165.1_LUNG-CANCER-MESOT_P_5e-07_MGI_20200608 P_5e-07 PRSWEB_PHECODE165.1_LUNG-CANCER-MESOT_P_5e-07_MGI_20200608 165.1 Lung cancer and mesothelioma Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-07) UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 7 0.67 0.000179377 0.0828 0.493 0.466-0.52 OR 0.561 0.155-2.04 0.561 0.155-2.04 0.624 0.261-1.49 0.624 0.261-1.49 0.705 0.417-1.19 0.705 0.417-1.19 1.09 0.789-1.5 1.09 0.789-1.5 1.14 0.914-1.43 1.14 0.914-1.43 1.16 0.877-1.55 0.292 1.05 0.782-1.4 0.763 1.23 0.927-1.63 0.152 FALSE FALSE FALSE FALSE Both 428 4270 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode165-1-lung-cancer-p-5e-07-mgi-20200608 prsweb-phecode165-1-lung-cancer-p-5e-07-mgi-20200608 PRSWEB_PHECODE165.1_LUNG-CANCER_P_5e-07_MGI_20200608 P_5e-07 PRSWEB_PHECODE165.1_LUNG-CANCER_P_5e-07_MGI_20200608 165.1 Lung cancer and mesothelioma Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-07) UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 7 0.67 0.000179377 0.0828 0.493 0.466-0.52 OR 0.561 0.155-2.04 0.561 0.155-2.04 0.624 0.261-1.49 0.624 0.261-1.49 0.705 0.417-1.19 0.705 0.417-1.19 1.09 0.789-1.5 1.09 0.789-1.5 1.14 0.914-1.43 1.14 0.914-1.43 1.16 0.877-1.55 0.292 1.05 0.782-1.4 0.763 1.23 0.927-1.63 0.152 FALSE FALSE FALSE FALSE Both 428 4270 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode165-1-gwas-catalog-r2019-05-03-x165-1-p-5e-09-mgi-20200608 prsweb-phecode165-1-gwas-catalog-r2019-05-03-x165-1-p-5e-09-mgi-20200608 PRSWEB_PHECODE165.1_GWAS-Catalog-r2019-05-03-X165.1_P_5e-09_MGI_20200608 P_5e-09 PRSWEB_PHECODE165.1_GWAS-Catalog-r2019-05-03-X165.1_P_5e-09_MGI_20200608 165.1 Lung cancer in ever smokers;Squamous cell lung carcinoma;Lung adenocarcinoma;Lung cancer;Lung cancer in never smokers;Familial squamous cell lung carcinoma;Familial lung adenocarcinoma;Familial lung cancer;Small cell lung carcinoma Binary 510 unique SNPs MGI Michigan Genomics Initiative Fixed threshold (5e-09) GWAS Catalog (2019-05-03) 19836008;24880342;28604730;29924316 https://www.ncbi.nlm.nih.gov/pubmed/?term=19836008+24880342+28604730+29924316 18 0.049 0.00222199 0.0827 0.526 0.498-0.554 OR 0.584 0.161-2.12 0.584 0.161-2.12 1.23 0.641-2.36 1.23 0.641-2.36 1 0.634-1.58 1 0.634-1.58 0.938 0.668-1.32 0.938 0.668-1.32 1.09 0.87-1.36 1.09 0.87-1.36 1.24 0.92-1.66 0.16 1.44 1.08-1.92 0.0135 1.34 1-1.8 0.0482 TRUE FALSE FALSE FALSE Both 428 4270 GRCh37/hg19 P<=5e-09 2020-06-08 prsweb-phecode165-1-gwas-catalog-r2019-05-03-x165-1-p-5e-08-mgi-20200608 prsweb-phecode165-1-gwas-catalog-r2019-05-03-x165-1-p-5e-08-mgi-20200608 PRSWEB_PHECODE165.1_GWAS-Catalog-r2019-05-03-X165.1_P_5e-08_MGI_20200608 P_5e-08 PRSWEB_PHECODE165.1_GWAS-Catalog-r2019-05-03-X165.1_P_5e-08_MGI_20200608 165.1 Lung cancer in ever smokers;Squamous cell lung carcinoma;Lung adenocarcinoma;Lung cancer;Lung cancer in never smokers;Familial squamous cell lung carcinoma;Familial lung adenocarcinoma;Familial lung cancer;Small cell lung carcinoma Binary 510 unique SNPs MGI Michigan Genomics Initiative GWAS Hits GWAS Catalog (2019-05-03) 19836008;24880342;28604730;29924316 https://www.ncbi.nlm.nih.gov/pubmed/?term=19836008+24880342+28604730+29924316 21 0.037 0.000789583 0.0827 0.52 0.492-0.547 OR 2.19 1.07-4.49 2.19 1.07-4.49 1.57 0.873-2.81 1.57 0.873-2.81 0.992 0.63-1.56 0.992 0.63-1.56 1.06 0.771-1.47 1.06 0.771-1.47 1.02 0.816-1.29 1.02 0.816-1.29 1.25 0.933-1.68 0.134 1.5 1.13-1.99 0.00566 1.28 0.954-1.72 0.0995 TRUE FALSE FALSE TRUE Both 428 4270 GRCh37/hg19 P<=5e-08 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000389/ScoringFiles/ phewas/PRSWEB_PHECODE165.1_GWAS-Catalog-r2019-05-03-X165.1_P_5e-08_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE165.1_GWAS-Catalog-r2019-05-03-X165.1_P_5e-08_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode165-1-20001-1001-pt-mgi-20200608 prsweb-phecode165-1-20001-1001-pt-mgi-20200608 PRSWEB_PHECODE165.1_20001-1001_PT_MGI_20200608 P&T PRSWEB_PHECODE165.1_20001-1001_PT_MGI_20200608 165.1 Cancer code, self-reported: lung cancer Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative P&T UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 71 0.21 0.000253099 0.0827 0.516 0.486-0.544 OR 1 0.374-2.68 1 0.374-2.68 1.54 0.859-2.77 1.54 0.859-2.77 1.13 0.733-1.74 1.13 0.733-1.74 1.22 0.894-1.66 1.22 0.894-1.66 1.06 0.847-1.33 1.06 0.847-1.33 1.08 0.808-1.44 0.609 1.2 0.903-1.59 0.21 1.16 0.877-1.55 0.293 FALSE FALSE FALSE FALSE Both 428 4270 GRCh37/hg19 P<=6.31e-05 2020-06-08 prsweb-phecode165-1-22140-pt-mgi-20200608 prsweb-phecode165-1-22140-pt-mgi-20200608 PRSWEB_PHECODE165.1_22140_PT_MGI_20200608 P&T PRSWEB_PHECODE165.1_22140_PT_MGI_20200608 165.1 Doctor diagnosed lung cancer (not mesothelioma) Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative P&T UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 5 0.82 0.00297657 0.0828 0.497 0.47-0.524 OR 0 0-0 0 0-0 0.28 0.0792-0.993 0.28 0.0792-0.993 0.706 0.418-1.19 0.706 0.418-1.19 0.964 0.69-1.35 0.964 0.69-1.35 1.12 0.896-1.4 1.12 0.896-1.4 1.22 0.921-1.61 0.165 0.991 0.74-1.33 0.952 1.19 0.898-1.58 0.227 FALSE FALSE FALSE FALSE Both 428 4270 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode165-1-c34-pt-mgi-20200608 prsweb-phecode165-1-c34-pt-mgi-20200608 PRSWEB_PHECODE165.1_C34_PT_MGI_20200608 P&T PRSWEB_PHECODE165.1_C34_PT_MGI_20200608 165.1 Diagnoses - main ICD10: C34 Malignant neoplasm of bronchus and lung Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative P&T UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 10 0.62 0.00269986 0.0828 0.491 0.464-0.519 OR 1.02 0.38-2.72 1.02 0.38-2.72 0.961 0.471-1.96 0.961 0.471-1.96 1.04 0.666-1.63 1.04 0.666-1.63 1.12 0.814-1.53 1.12 0.814-1.53 1.12 0.894-1.4 1.12 0.894-1.4 1.04 0.787-1.38 0.775 0.926 0.695-1.23 0.601 1.11 0.839-1.46 0.477 FALSE FALSE FALSE FALSE Both 428 4270 GRCh37/hg19 P<=1.26e-06 2020-06-08 prsweb-phecode165-1-gwas-catalog-r2019-05-03-x165-1-pt-mgi-20200608 prsweb-phecode165-1-gwas-catalog-r2019-05-03-x165-1-pt-mgi-20200608 PRSWEB_PHECODE165.1_GWAS-Catalog-r2019-05-03-X165.1_PT_MGI_20200608 P&T PRSWEB_PHECODE165.1_GWAS-Catalog-r2019-05-03-X165.1_PT_MGI_20200608 165.1 Lung cancer in ever smokers;Squamous cell lung carcinoma;Lung adenocarcinoma;Lung cancer;Lung cancer in never smokers;Familial squamous cell lung carcinoma;Familial lung adenocarcinoma;Familial lung cancer;Small cell lung carcinoma Binary 510 unique SNPs MGI Michigan Genomics Initiative P&T GWAS Catalog (2019-05-03) 19836008;24880342;28604730;29924316 https://www.ncbi.nlm.nih.gov/pubmed/?term=19836008+24880342+28604730+29924316 14 0.025 0.00274864 0.0827 0.529 0.503-0.558 OR 1.75 0.796-3.85 1.75 0.796-3.85 1.22 0.638-2.34 1.22 0.638-2.34 1.19 0.782-1.82 1.19 0.782-1.82 1.28 0.948-1.74 1.28 0.948-1.74 1.1 0.883-1.38 1.1 0.883-1.38 1.22 0.906-1.63 0.193 1.36 1.02-1.82 0.0349 1.31 0.982-1.76 0.066 TRUE FALSE FALSE TRUE Both 428 4270 GRCh37/hg19 P<=1e-10 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000391/ScoringFiles/ phewas/PRSWEB_PHECODE165.1_GWAS-Catalog-r2019-05-03-X165.1_PT_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE165.1_GWAS-Catalog-r2019-05-03-X165.1_PT_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode165-1-ukbb-saige-hrc-x165-1-pt-mgi-20200608 prsweb-phecode165-1-ukbb-saige-hrc-x165-1-pt-mgi-20200608 PRSWEB_PHECODE165.1_UKBB-SAIGE-HRC-X165.1_PT_MGI_20200608 P&T PRSWEB_PHECODE165.1_UKBB-SAIGE-HRC-X165.1_PT_MGI_20200608 165.1 Cancer of bronchus; lung Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative P&T UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 75 0.024 0.000256547 0.0827 0.525 0.496-0.554 OR 2.21 1.08-4.51 2.21 1.08-4.51 1.82 1.05-3.16 1.82 1.05-3.16 1.3 0.861-1.96 1.3 0.861-1.96 1.17 0.858-1.6 1.17 0.858-1.6 1.15 0.925-1.44 1.15 0.925-1.44 1.01 0.757-1.36 0.926 1.21 0.916-1.61 0.178 1.24 0.938-1.64 0.131 TRUE FALSE FALSE TRUE Both 428 4270 GRCh37/hg19 P<=3.16e-05 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000396/ScoringFiles/ phewas/PRSWEB_PHECODE165.1_UKBB-SAIGE-HRC-X165.1_PT_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE165.1_UKBB-SAIGE-HRC-X165.1_PT_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode165-1-c3-bronchus-lung-prs-cs-mgi-20200608 prsweb-phecode165-1-c3-bronchus-lung-prs-cs-mgi-20200608 PRSWEB_PHECODE165.1_C3-BRONCHUS-LUNG_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE165.1_C3-BRONCHUS-LUNG_PRS-CS_MGI_20200608 165.1 Malignant neoplasm of bronchus and lung Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative PRS-CS UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1109069 0.015 3.18855e-07 0.0827 0.533 0.505-0.562 OR 1.96 0.926-4.14 1.96 0.926-4.14 1.82 1.04-3.16 1.82 1.04-3.16 1.34 0.896-2.01 1.34 0.896-2.01 1.34 0.993-1.81 1.34 0.993-1.81 1.18 0.943-1.47 1.18 0.943-1.47 1.14 0.85-1.54 0.373 1.4 1.05-1.87 0.0206 1.38 1.03-1.84 0.0285 TRUE FALSE FALSE TRUE Both 428 4270 GRCh37/hg19 auto https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000388/ScoringFiles/ phewas/PRSWEB_PHECODE165.1_C3-BRONCHUS-LUNG_PRS-CS_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE165.1_C3-BRONCHUS-LUNG_PRS-CS_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode165-1-c34-prs-cs-mgi-20200608 prsweb-phecode165-1-c34-prs-cs-mgi-20200608 PRSWEB_PHECODE165.1_C34_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE165.1_C34_PRS-CS_MGI_20200608 165.1 Diagnoses - main ICD10: C34 Malignant neoplasm of bronchus and lung Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative PRS-CS UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1108949 0.057 1.49796e-05 0.0827 0.525 0.494-0.552 OR 1.73 0.786-3.81 1.73 0.786-3.81 1.34 0.714-2.5 1.34 0.714-2.5 1.25 0.821-1.89 1.25 0.821-1.89 1.15 0.838-1.57 1.15 0.838-1.57 1.21 0.967-1.5 1.21 0.967-1.5 0.883 0.66-1.18 0.404 1.05 0.794-1.39 0.725 1.17 0.89-1.54 0.258 FALSE FALSE FALSE FALSE Both 428 4270 GRCh37/hg19 auto 2020-06-08 prsweb-phecode165-1-lung-cancer-mesot-prs-cs-mgi-20200608 prsweb-phecode165-1-lung-cancer-mesot-prs-cs-mgi-20200608 PRSWEB_PHECODE165.1_LUNG-CANCER-MESOT_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE165.1_LUNG-CANCER-MESOT_PRS-CS_MGI_20200608 165.1 Lung cancer and mesothelioma Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative PRS-CS UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1110438 0.0064 3.78057e-06 0.0826 0.539 0.508-0.568 OR 2.18 1.06-4.46 2.18 1.06-4.46 1.68 0.954-2.97 1.68 0.954-2.97 1.5 1.02-2.21 1.5 1.02-2.21 1.23 0.907-1.68 1.23 0.907-1.68 1.12 0.897-1.4 1.12 0.897-1.4 1.2 0.893-1.6 0.228 1.35 1.01-1.8 0.0418 1.31 0.98-1.75 0.0686 TRUE FALSE FALSE TRUE Both 428 4270 GRCh37/hg19 auto https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000394/ScoringFiles/ phewas/PRSWEB_PHECODE165.1_LUNG-CANCER-MESOT_PRS-CS_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE165.1_LUNG-CANCER-MESOT_PRS-CS_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode165-1-lung-cancer-prs-cs-mgi-20200608 prsweb-phecode165-1-lung-cancer-prs-cs-mgi-20200608 PRSWEB_PHECODE165.1_LUNG-CANCER_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE165.1_LUNG-CANCER_PRS-CS_MGI_20200608 165.1 Lung cancer and mesothelioma Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative PRS-CS UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1110438 0.0064 3.78057e-06 0.0826 0.539 0.508-0.568 OR 2.18 1.06-4.46 2.18 1.06-4.46 1.68 0.954-2.97 1.68 0.954-2.97 1.5 1.02-2.21 1.5 1.02-2.21 1.23 0.907-1.68 1.23 0.907-1.68 1.12 0.897-1.4 1.12 0.897-1.4 1.2 0.893-1.6 0.228 1.35 1.01-1.8 0.0418 1.31 0.98-1.75 0.0686 TRUE FALSE FALSE TRUE Both 428 4270 GRCh37/hg19 auto https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000393/ScoringFiles/ phewas/PRSWEB_PHECODE165.1_LUNG-CANCER_PRS-CS_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE165.1_LUNG-CANCER_PRS-CS_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode165-1-ukbb-saige-hrc-x165-1-prs-cs-mgi-20200608 prsweb-phecode165-1-ukbb-saige-hrc-x165-1-prs-cs-mgi-20200608 PRSWEB_PHECODE165.1_UKBB-SAIGE-HRC-X165.1_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE165.1_UKBB-SAIGE-HRC-X165.1_PRS-CS_MGI_20200608 165.1 Cancer of bronchus; lung Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative PRS-CS UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1119238 0.014 0.000177393 0.0827 0.533 0.505-0.562 OR 1.27 0.514-3.12 1.27 0.514-3.12 1.44 0.788-2.64 1.44 0.788-2.64 1.6 1.1-2.34 1.6 1.1-2.34 1.45 1.08-1.94 1.45 1.08-1.94 1.21 0.975-1.51 1.21 0.975-1.51 1.06 0.789-1.43 0.694 1.28 0.963-1.7 0.0886 1.34 1.01-1.78 0.0411 TRUE FALSE FALSE TRUE Both 428 4270 GRCh37/hg19 auto https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000395/ScoringFiles/ phewas/PRSWEB_PHECODE165.1_UKBB-SAIGE-HRC-X165.1_PRS-CS_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE165.1_UKBB-SAIGE-HRC-X165.1_PRS-CS_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode165-1-20001-1001-lassosum-mgi-20200608 prsweb-phecode165-1-20001-1001-lassosum-mgi-20200608 PRSWEB_PHECODE165.1_20001-1001_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE165.1_20001-1001_LASSOSUM_MGI_20200608 165.1 Cancer code, self-reported: lung cancer Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative lassosum UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 5700 0.4 0.00279646 0.0828 0.513 0.484-0.541 OR 0.801 0.266-2.41 0.801 0.266-2.41 0.981 0.48-2 0.981 0.48-2 1.1 0.709-1.7 1.1 0.709-1.7 1.18 0.862-1.61 1.18 0.862-1.61 1.08 0.861-1.35 1.08 0.861-1.35 0.963 0.725-1.28 0.793 1.02 0.774-1.35 0.867 1.07 0.809-1.41 0.646 FALSE FALSE FALSE FALSE Both 428 4270 GRCh37/hg19 s=0.5;Lambda=0.1 2020-06-08 prsweb-phecode165-1-22140-lassosum-mgi-20200608 prsweb-phecode165-1-22140-lassosum-mgi-20200608 PRSWEB_PHECODE165.1_22140_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE165.1_22140_LASSOSUM_MGI_20200608 165.1 Doctor diagnosed lung cancer (not mesothelioma) Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative lassosum UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 97897 0.7 0.000576128 0.0828 0.503 0.474-0.529 OR 0.806 0.268-2.43 0.806 0.268-2.43 0.511 0.196-1.33 0.511 0.196-1.33 1.19 0.781-1.82 1.19 0.781-1.82 0.935 0.667-1.31 0.935 0.667-1.31 0.93 0.737-1.17 0.93 0.737-1.17 1.15 0.865-1.52 0.34 1.16 0.873-1.53 0.313 1.01 0.756-1.35 0.951 FALSE FALSE FALSE FALSE Both 428 4270 GRCh37/hg19 s=1;Lambda=0.1 2020-06-08 prsweb-phecode165-1-c3-bronchus-lung-lassosum-mgi-20200608 prsweb-phecode165-1-c3-bronchus-lung-lassosum-mgi-20200608 PRSWEB_PHECODE165.1_C3-BRONCHUS-LUNG_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE165.1_C3-BRONCHUS-LUNG_LASSOSUM_MGI_20200608 165.1 Malignant neoplasm of bronchus and lung Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative lassosum UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 380802 0.12 0.000805404 0.0827 0.521 0.493-0.548 OR 1.75 0.795-3.85 1.75 0.795-3.85 1.46 0.798-2.67 1.46 0.798-2.67 1.01 0.638-1.59 1.01 0.638-1.59 0.895 0.633-1.27 0.895 0.633-1.27 1.31 1.05-1.62 1.31 1.05-1.62 0.907 0.679-1.21 0.51 0.969 0.729-1.29 0.83 1.24 0.946-1.63 0.119 FALSE FALSE FALSE FALSE Both 428 4270 GRCh37/hg19 s=0.2;Lambda=0.01129 2020-06-08 prsweb-phecode165-1-c34-lassosum-mgi-20200608 prsweb-phecode165-1-c34-lassosum-mgi-20200608 PRSWEB_PHECODE165.1_C34_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE165.1_C34_LASSOSUM_MGI_20200608 165.1 Diagnoses - main ICD10: C34 Malignant neoplasm of bronchus and lung Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative lassosum UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 35698 0.35 0.00209428 0.0828 0.51 0.481-0.538 OR 0.808 0.268-2.44 0.808 0.268-2.44 0.99 0.485-2.02 0.99 0.485-2.02 1.31 0.869-1.98 1.31 0.869-1.98 0.943 0.672-1.32 0.943 0.672-1.32 0.864 0.681-1.1 0.864 0.681-1.1 1.45 1.09-1.93 0.01 1.34 1.01-1.79 0.0436 1.07 0.793-1.45 0.65 FALSE FALSE FALSE FALSE Both 428 4270 GRCh37/hg19 s=0.2;Lambda=0.02976 2020-06-08 prsweb-phecode165-1-lung-cancer-mesot-lassosum-mgi-20200608 prsweb-phecode165-1-lung-cancer-mesot-lassosum-mgi-20200608 PRSWEB_PHECODE165.1_LUNG-CANCER-MESOT_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE165.1_LUNG-CANCER-MESOT_LASSOSUM_MGI_20200608 165.1 Lung cancer and mesothelioma Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative lassosum UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 73073 0.37 0.000896352 0.0828 0.516 0.488-0.546 OR 0.564 0.155-2.05 0.564 0.155-2.05 0.861 0.405-1.83 0.861 0.405-1.83 0.957 0.601-1.52 0.957 0.601-1.52 1.05 0.758-1.46 1.05 0.758-1.46 1.1 0.876-1.37 1.1 0.876-1.37 1.09 0.82-1.45 0.549 1.1 0.825-1.46 0.522 1.14 0.863-1.51 0.352 FALSE FALSE FALSE FALSE Both 428 4270 GRCh37/hg19 s=0.5;Lambda=0.02336 2020-06-08 prsweb-phecode165-1-lung-cancer-lassosum-mgi-20200608 prsweb-phecode165-1-lung-cancer-lassosum-mgi-20200608 PRSWEB_PHECODE165.1_LUNG-CANCER_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE165.1_LUNG-CANCER_LASSOSUM_MGI_20200608 165.1 Lung cancer and mesothelioma Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative lassosum UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 73073 0.37 0.000896352 0.0828 0.516 0.488-0.546 OR 0.564 0.155-2.05 0.564 0.155-2.05 0.861 0.405-1.83 0.861 0.405-1.83 0.957 0.601-1.52 0.957 0.601-1.52 1.05 0.758-1.46 1.05 0.758-1.46 1.1 0.876-1.37 1.1 0.876-1.37 1.09 0.82-1.45 0.549 1.1 0.825-1.46 0.522 1.14 0.863-1.51 0.352 FALSE FALSE FALSE FALSE Both 428 4270 GRCh37/hg19 s=0.5;Lambda=0.02336 2020-06-08 prsweb-phecode165-1-ukbb-saige-hrc-x165-1-lassosum-mgi-20200608 prsweb-phecode165-1-ukbb-saige-hrc-x165-1-lassosum-mgi-20200608 PRSWEB_PHECODE165.1_UKBB-SAIGE-HRC-X165.1_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE165.1_UKBB-SAIGE-HRC-X165.1_LASSOSUM_MGI_20200608 165.1 Cancer of bronchus; lung Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative lassosum UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 46920 0.033 0.00108478 0.0827 0.528 0.503-0.556 OR 1.03 0.387-2.77 1.03 0.387-2.77 0.984 0.482-2.01 0.984 0.482-2.01 1.1 0.711-1.71 1.1 0.711-1.71 1.02 0.736-1.42 1.02 0.736-1.42 1.07 0.855-1.34 1.07 0.855-1.34 1.11 0.832-1.49 0.466 1.31 0.991-1.74 0.0577 1.21 0.906-1.61 0.198 TRUE FALSE FALSE TRUE Both 428 4270 GRCh37/hg19 s=0.2;Lambda=0.02336 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000397/ScoringFiles/ phewas/PRSWEB_PHECODE165.1_UKBB-SAIGE-HRC-X165.1_LASSOSUM_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE165.1_UKBB-SAIGE-HRC-X165.1_LASSOSUM_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode165-1-gwas-catalog-r2019-05-03-x165-1-p-5e-05-ukb-20200608 prsweb-phecode165-1-gwas-catalog-r2019-05-03-x165-1-p-5e-05-ukb-20200608 PRSWEB_PHECODE165.1_GWAS-Catalog-r2019-05-03-X165.1_P_5e-05_UKB_20200608 P_5e-05 PRSWEB_PHECODE165.1_GWAS-Catalog-r2019-05-03-X165.1_P_5e-05_UKB_20200608 165.1 Lung cancer in ever smokers;Squamous cell lung carcinoma;Lung adenocarcinoma;Lung cancer;Lung cancer in never smokers;Familial squamous cell lung carcinoma;Familial lung adenocarcinoma;Familial lung cancer;Small cell lung carcinoma Binary 510 unique SNPs UKB UK Biobank Fixed threshold (5e-05) GWAS Catalog (2019-05-03) 19836008;24880342;28604730;29924316 https://www.ncbi.nlm.nih.gov/pubmed/?term=19836008+24880342+28604730+29924316 289 0.0019 0.0017924 0.0826 0.516 0.499-0.534 OR 1.58 0.949-2.63 1.58 0.949-2.63 1.24 0.83-1.85 1.24 0.83-1.85 1.3 1.01-1.68 1.3 1.01-1.68 1.24 1.02-1.5 1.24 1.02-1.5 1.08 0.937-1.24 1.08 0.937-1.24 1.22 1.02-1.46 0.0299 1.28 1.07-1.53 0.00668 1.26 1.05-1.5 0.0127 TRUE FALSE FALSE FALSE Both 1109 11092 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode165-1-gwas-catalog-r2019-05-03-x165-1-p-5e-06-ukb-20200608 prsweb-phecode165-1-gwas-catalog-r2019-05-03-x165-1-p-5e-06-ukb-20200608 PRSWEB_PHECODE165.1_GWAS-Catalog-r2019-05-03-X165.1_P_5e-06_UKB_20200608 P_5e-06 PRSWEB_PHECODE165.1_GWAS-Catalog-r2019-05-03-X165.1_P_5e-06_UKB_20200608 165.1 Lung cancer in ever smokers;Squamous cell lung carcinoma;Lung adenocarcinoma;Lung cancer;Lung cancer in never smokers;Familial squamous cell lung carcinoma;Familial lung adenocarcinoma;Familial lung cancer;Small cell lung carcinoma Binary 510 unique SNPs UKB UK Biobank Fixed threshold (5e-06) GWAS Catalog (2019-05-03) 19836008;24880342;28604730;29924316 https://www.ncbi.nlm.nih.gov/pubmed/?term=19836008+24880342+28604730+29924316 210 0.00038 0.00152072 0.0825 0.52 0.504-0.537 OR 1.3 0.75-2.27 1.3 0.75-2.27 1.66 1.16-2.37 1.66 1.16-2.37 1.31 1.01-1.68 1.31 1.01-1.68 1.3 1.08-1.57 1.3 1.08-1.57 1.1 0.955-1.26 1.1 0.955-1.26 1.24 1.03-1.48 0.0234 1.37 1.15-1.64 0.000525 1.32 1.1-1.58 0.00265 TRUE FALSE FALSE FALSE Both 1109 11092 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode165-1-gwas-catalog-r2019-05-03-x165-1-p-5e-07-ukb-20200608 prsweb-phecode165-1-gwas-catalog-r2019-05-03-x165-1-p-5e-07-ukb-20200608 PRSWEB_PHECODE165.1_GWAS-Catalog-r2019-05-03-X165.1_P_5e-07_UKB_20200608 P_5e-07 PRSWEB_PHECODE165.1_GWAS-Catalog-r2019-05-03-X165.1_P_5e-07_UKB_20200608 165.1 Lung cancer in ever smokers;Squamous cell lung carcinoma;Lung adenocarcinoma;Lung cancer;Lung cancer in never smokers;Familial squamous cell lung carcinoma;Familial lung adenocarcinoma;Familial lung cancer;Small cell lung carcinoma Binary 510 unique SNPs UKB UK Biobank Fixed threshold (5e-07) GWAS Catalog (2019-05-03) 19836008;24880342;28604730;29924316 https://www.ncbi.nlm.nih.gov/pubmed/?term=19836008+24880342+28604730+29924316 58 3.8e-06 0.00166981 0.0825 0.531 0.514-0.549 OR 1.58 0.948-2.63 1.58 0.948-2.63 1.29 0.866-1.91 1.29 0.866-1.91 1.32 1.03-1.71 1.32 1.03-1.71 1.31 1.09-1.58 1.31 1.09-1.58 1.31 1.14-1.5 1.31 1.14-1.5 1.07 0.887-1.29 0.489 1.26 1.05-1.51 0.0118 1.45 1.21-1.72 3.55e-05 TRUE FALSE FALSE FALSE Both 1109 11092 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode165-1-gwas-catalog-r2019-05-03-x165-1-p-5e-09-ukb-20200608 prsweb-phecode165-1-gwas-catalog-r2019-05-03-x165-1-p-5e-09-ukb-20200608 PRSWEB_PHECODE165.1_GWAS-Catalog-r2019-05-03-X165.1_P_5e-09_UKB_20200608 P_5e-09 PRSWEB_PHECODE165.1_GWAS-Catalog-r2019-05-03-X165.1_P_5e-09_UKB_20200608 165.1 Lung cancer in ever smokers;Squamous cell lung carcinoma;Lung adenocarcinoma;Lung cancer;Lung cancer in never smokers;Familial squamous cell lung carcinoma;Familial lung adenocarcinoma;Familial lung cancer;Small cell lung carcinoma Binary 510 unique SNPs UKB UK Biobank Fixed threshold (5e-09) GWAS Catalog (2019-05-03) 19836008;24880342;28604730;29924316 https://www.ncbi.nlm.nih.gov/pubmed/?term=19836008+24880342+28604730+29924316 18 2.8e-10 0.0073769 0.0824 0.551 0.533-0.568 OR 1.94 1.22-3.1 1.94 1.22-3.1 1.8 1.28-2.55 1.8 1.28-2.55 1.7 1.35-2.15 1.7 1.35-2.15 1.49 1.24-1.78 1.49 1.24-1.78 1.3 1.14-1.49 1.3 1.14-1.49 1.35 1.12-1.63 0.00189 1.49 1.24-1.8 2.21e-05 1.67 1.39-2 3.96e-08 TRUE FALSE FALSE FALSE Both 1109 11092 GRCh37/hg19 P<=5e-09 2020-06-08 prsweb-phecode165-1-gwas-catalog-r2019-05-03-x165-1-p-5e-08-ukb-20200608 prsweb-phecode165-1-gwas-catalog-r2019-05-03-x165-1-p-5e-08-ukb-20200608 PRSWEB_PHECODE165.1_GWAS-Catalog-r2019-05-03-X165.1_P_5e-08_UKB_20200608 P_5e-08 PRSWEB_PHECODE165.1_GWAS-Catalog-r2019-05-03-X165.1_P_5e-08_UKB_20200608 165.1 Lung cancer in ever smokers;Squamous cell lung carcinoma;Lung adenocarcinoma;Lung cancer;Lung cancer in never smokers;Familial squamous cell lung carcinoma;Familial lung adenocarcinoma;Familial lung cancer;Small cell lung carcinoma Binary 510 unique SNPs UKB UK Biobank GWAS Hits GWAS Catalog (2019-05-03) 19836008;24880342;28604730;29924316 https://www.ncbi.nlm.nih.gov/pubmed/?term=19836008+24880342+28604730+29924316 21 9.2e-09 0.00544927 0.0824 0.543 0.526-0.562 OR 0.852 0.437-1.66 0.852 0.437-1.66 1.57 1.09-2.26 1.57 1.09-2.26 1.42 1.11-1.82 1.42 1.11-1.82 1.44 1.2-1.73 1.44 1.2-1.73 1.37 1.2-1.57 1.37 1.2-1.57 1.27 1.05-1.53 0.0134 1.31 1.09-1.57 0.00476 1.63 1.36-1.95 7.43e-08 TRUE FALSE FALSE TRUE Both 1109 11092 GRCh37/hg19 P<=5e-08 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000390/ScoringFiles/ phewas/PRSWEB_PHECODE165.1_GWAS-Catalog-r2019-05-03-X165.1_P_5e-08_UKB_20200608/all.tsv phewas/PRSWEB_PHECODE165.1_GWAS-Catalog-r2019-05-03-X165.1_P_5e-08_UKB_20200608/exclusion.tsv 2020-06-08 prsweb-phecode165-1-gwas-catalog-r2019-05-03-x165-1-pt-ukb-20200608 prsweb-phecode165-1-gwas-catalog-r2019-05-03-x165-1-pt-ukb-20200608 PRSWEB_PHECODE165.1_GWAS-Catalog-r2019-05-03-X165.1_PT_UKB_20200608 P&T PRSWEB_PHECODE165.1_GWAS-Catalog-r2019-05-03-X165.1_PT_UKB_20200608 165.1 Lung cancer in ever smokers;Squamous cell lung carcinoma;Lung adenocarcinoma;Lung cancer;Lung cancer in never smokers;Familial squamous cell lung carcinoma;Familial lung adenocarcinoma;Familial lung cancer;Small cell lung carcinoma Binary 510 unique SNPs UKB UK Biobank P&T GWAS Catalog (2019-05-03) 19836008;24880342;28604730;29924316 https://www.ncbi.nlm.nih.gov/pubmed/?term=19836008+24880342+28604730+29924316 19 1.7e-10 0.00761491 0.0824 0.552 0.534-0.569 OR 1.94 1.22-3.1 1.94 1.22-3.1 1.66 1.16-2.37 1.66 1.16-2.37 1.6 1.27-2.03 1.6 1.27-2.03 1.51 1.26-1.8 1.51 1.26-1.8 1.31 1.15-1.5 1.31 1.15-1.5 1.39 1.15-1.68 0.000653 1.53 1.27-1.84 9.49e-06 1.7 1.42-2.05 1.17e-08 TRUE FALSE FALSE TRUE Both 1109 11092 GRCh37/hg19 P<=2.51e-08 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000392/ScoringFiles/ phewas/PRSWEB_PHECODE165.1_GWAS-Catalog-r2019-05-03-X165.1_PT_UKB_20200608/all.tsv phewas/PRSWEB_PHECODE165.1_GWAS-Catalog-r2019-05-03-X165.1_PT_UKB_20200608/exclusion.tsv 2020-06-08 prsweb-phecode170-ukbb-saige-hrc-x170-p-5e-05-mgi-20200608 prsweb-phecode170-ukbb-saige-hrc-x170-p-5e-05-mgi-20200608 PRSWEB_PHECODE170_UKBB-SAIGE-HRC-X170_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE170_UKBB-SAIGE-HRC-X170_P_5e-05_MGI_20200608 170 Cancer of bone and connective tissue Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 93 0.63 6.83825e-06 0.083 0.501 0.481-0.522 OR 0.701 0.293-1.68 0.701 0.293-1.68 0.867 0.494-1.52 0.867 0.494-1.52 0.91 0.64-1.29 0.91 0.64-1.29 1 0.784-1.28 1 0.784-1.28 1.06 0.899-1.26 1.06 0.899-1.26 0.916 0.739-1.14 0.426 1.09 0.887-1.34 0.406 1.07 0.865-1.31 0.553 FALSE FALSE FALSE FALSE Both 769 7644 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode170-ukbb-saige-hrc-x170-pt-mgi-20200608 prsweb-phecode170-ukbb-saige-hrc-x170-pt-mgi-20200608 PRSWEB_PHECODE170_UKBB-SAIGE-HRC-X170_PT_MGI_20200608 P&T PRSWEB_PHECODE170_UKBB-SAIGE-HRC-X170_PT_MGI_20200608 170 Cancer of bone and connective tissue Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative P&T UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 27 0.56 0.000351878 0.083 0.493 0.471-0.514 OR 0.826 0.368-1.85 0.826 0.368-1.85 0.937 0.543-1.61 0.937 0.543-1.61 0.915 0.644-1.3 0.915 0.644-1.3 0.99 0.773-1.27 0.99 0.773-1.27 1.1 0.93-1.3 1.1 0.93-1.3 0.867 0.702-1.07 0.185 0.907 0.736-1.12 0.358 1.02 0.831-1.25 0.86 FALSE FALSE FALSE FALSE Both 769 7644 GRCh37/hg19 P<=1e-05 2020-06-08 prsweb-phecode170-ukbb-saige-hrc-x170-prs-cs-mgi-20200608 prsweb-phecode170-ukbb-saige-hrc-x170-prs-cs-mgi-20200608 PRSWEB_PHECODE170_UKBB-SAIGE-HRC-X170_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE170_UKBB-SAIGE-HRC-X170_PRS-CS_MGI_20200608 170 Cancer of bone and connective tissue Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative PRS-CS UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1119238 0.053 0.000274469 0.083 0.522 0.502-0.543 OR 0.824 0.367-1.85 0.824 0.367-1.85 0.865 0.493-1.52 0.865 0.493-1.52 1.1 0.798-1.53 1.1 0.798-1.53 1.12 0.887-1.42 1.12 0.887-1.42 1.16 0.982-1.37 1.16 0.982-1.37 1.25 1.01-1.55 0.0399 1.13 0.907-1.4 0.279 1.3 1.05-1.61 0.0145 FALSE FALSE FALSE FALSE Both 769 7644 GRCh37/hg19 auto 2020-06-08 prsweb-phecode170-ukbb-saige-hrc-x170-lassosum-mgi-20200608 prsweb-phecode170-ukbb-saige-hrc-x170-lassosum-mgi-20200608 PRSWEB_PHECODE170_UKBB-SAIGE-HRC-X170_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE170_UKBB-SAIGE-HRC-X170_LASSOSUM_MGI_20200608 170 Cancer of bone and connective tissue Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative lassosum UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 245000 0.16 0.00159018 0.083 0.515 0.495-0.535 OR 0.827 0.369-1.85 0.827 0.369-1.85 0.806 0.45-1.44 0.806 0.45-1.44 1.08 0.78-1.51 1.08 0.78-1.51 0.98 0.764-1.26 0.98 0.764-1.26 1.07 0.9-1.26 1.07 0.9-1.26 1.18 0.95-1.46 0.136 1.17 0.941-1.45 0.16 1.18 0.955-1.46 0.125 FALSE FALSE FALSE FALSE Both 769 7644 GRCh37/hg19 s=0.2;Lambda=0.02976 2020-06-08 prsweb-phecode170-1-20001-1063-p-5e-05-mgi-20200608 prsweb-phecode170-1-20001-1063-p-5e-05-mgi-20200608 PRSWEB_PHECODE170.1_20001-1063_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE170.1_20001-1063_P_5e-05_MGI_20200608 170.1 Cancer code, self-reported: primary bone cancer Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 48 0.38 0.000171578 0.0829 0.512 0.479-0.546 OR 1.59 0.635-3.97 1.59 0.635-3.97 0.956 0.422-2.16 0.956 0.422-2.16 1.04 0.629-1.73 1.04 0.629-1.73 1.3 0.926-1.83 1.3 0.926-1.83 1.17 0.913-1.5 1.17 0.913-1.5 0.88 0.637-1.22 0.441 0.983 0.717-1.35 0.918 1.11 0.818-1.51 0.498 FALSE FALSE FALSE FALSE Both 335 3337 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode170-1-20001-1063-p-5e-06-mgi-20200608 prsweb-phecode170-1-20001-1063-p-5e-06-mgi-20200608 PRSWEB_PHECODE170.1_20001-1063_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE170.1_20001-1063_P_5e-06_MGI_20200608 170.1 Cancer code, self-reported: primary bone cancer Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 5 0.22 0.000409866 0.0829 0.504 0.471-0.538 OR 1 0.328-3.06 1 0.328-3.06 1.41 0.704-2.81 1.41 0.704-2.81 1.55 1.01-2.39 1.55 1.01-2.39 1.3 0.924-1.83 1.3 0.924-1.83 1.22 0.955-1.57 1.22 0.955-1.57 1.11 0.807-1.54 0.512 1.04 0.748-1.44 0.82 1.25 0.916-1.71 0.159 FALSE FALSE FALSE FALSE Both 335 3337 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode170-1-20001-1063-pt-mgi-20200608 prsweb-phecode170-1-20001-1063-pt-mgi-20200608 PRSWEB_PHECODE170.1_20001-1063_PT_MGI_20200608 P&T PRSWEB_PHECODE170.1_20001-1063_PT_MGI_20200608 170.1 Cancer code, self-reported: primary bone cancer Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative P&T UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 7 0.35 0.00223299 0.0829 0.508 0.478-0.54 OR 1.01 0.33-3.08 1.01 0.33-3.08 0.658 0.251-1.73 0.658 0.251-1.73 1.29 0.814-2.06 1.29 0.814-2.06 0.93 0.634-1.36 0.93 0.634-1.36 1.12 0.87-1.44 1.12 0.87-1.44 1.09 0.786-1.51 0.609 1.17 0.85-1.61 0.335 1.22 0.885-1.67 0.229 FALSE FALSE FALSE FALSE Both 335 3337 GRCh37/hg19 P<=6.31e-06 2020-06-08 prsweb-phecode170-1-20001-1063-prs-cs-mgi-20200608 prsweb-phecode170-1-20001-1063-prs-cs-mgi-20200608 PRSWEB_PHECODE170.1_20001-1063_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE170.1_20001-1063_PRS-CS_MGI_20200608 170.1 Cancer code, self-reported: primary bone cancer Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative PRS-CS UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 839358 0.52 0.00129516 0.0829 0.51 0.478-0.543 OR 1.31 0.482-3.57 1.31 0.482-3.57 1.26 0.61-2.61 1.26 0.61-2.61 1.17 0.719-1.89 1.17 0.719-1.89 1.23 0.871-1.74 1.23 0.871-1.74 1.09 0.845-1.4 1.09 0.845-1.4 1.08 0.788-1.49 0.617 1.07 0.774-1.47 0.689 1.14 0.831-1.56 0.418 FALSE FALSE FALSE FALSE Both 335 3337 GRCh37/hg19 auto 2020-06-08 prsweb-phecode170-1-ukbb-saige-hrc-x170-1-prs-cs-mgi-20200608 prsweb-phecode170-1-ukbb-saige-hrc-x170-1-prs-cs-mgi-20200608 PRSWEB_PHECODE170.1_UKBB-SAIGE-HRC-X170.1_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE170.1_UKBB-SAIGE-HRC-X170.1_PRS-CS_MGI_20200608 170.1 Bone cancer Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative PRS-CS UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1119238 0.2 0.000650284 0.0829 0.52 0.488-0.553 OR 1.58 0.633-3.95 1.58 0.633-3.95 1.1 0.509-2.36 1.1 0.509-2.36 1.41 0.904-2.21 1.41 0.904-2.21 1.4 1-1.95 1.4 1-1.95 1.14 0.883-1.46 1.14 0.883-1.46 1.18 0.854-1.62 0.32 1.06 0.765-1.48 0.717 1.23 0.897-1.7 0.195 FALSE FALSE FALSE FALSE Both 335 3337 GRCh37/hg19 auto 2020-06-08 prsweb-phecode170-1-20001-1063-lassosum-mgi-20200608 prsweb-phecode170-1-20001-1063-lassosum-mgi-20200608 PRSWEB_PHECODE170.1_20001-1063_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE170.1_20001-1063_LASSOSUM_MGI_20200608 170.1 Cancer code, self-reported: primary bone cancer Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative lassosum UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 2805117 0.92 0.00294892 0.0829 0.498 0.466-0.53 OR 1.3 0.477-3.52 1.3 0.477-3.52 0.957 0.423-2.16 0.957 0.423-2.16 0.978 0.582-1.64 0.978 0.582-1.64 1.03 0.709-1.48 1.03 0.709-1.48 0.914 0.702-1.19 0.914 0.702-1.19 1.05 0.767-1.43 0.77 1.02 0.741-1.39 0.922 0.931 0.676-1.28 0.663 FALSE FALSE FALSE FALSE Both 335 3337 GRCh37/hg19 s=1;Lambda=0.001 2020-06-08 prsweb-phecode170-1-ukbb-saige-hrc-x170-1-lassosum-mgi-20200608 prsweb-phecode170-1-ukbb-saige-hrc-x170-1-lassosum-mgi-20200608 PRSWEB_PHECODE170.1_UKBB-SAIGE-HRC-X170.1_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE170.1_UKBB-SAIGE-HRC-X170.1_LASSOSUM_MGI_20200608 170.1 Bone cancer Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative lassosum UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 141650 0.66 0.0014025 0.0829 0.515 0.483-0.548 OR 0 0-0 0 0-0 0.655 0.25-1.72 0.655 0.25-1.72 1.04 0.625-1.72 1.04 0.625-1.72 1.3 0.925-1.83 1.3 0.925-1.83 1.24 0.972-1.59 1.24 0.972-1.59 0.96 0.695-1.33 0.804 0.96 0.695-1.33 0.802 1.21 0.89-1.65 0.222 FALSE FALSE FALSE FALSE Both 335 3337 GRCh37/hg19 s=0.5;Lambda=0.07848 2020-06-08 prsweb-phecode170-2-20001-1068-p-5e-05-mgi-20200608 prsweb-phecode170-2-20001-1068-p-5e-05-mgi-20200608 PRSWEB_PHECODE170.2_20001-1068_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE170.2_20001-1068_P_5e-05_MGI_20200608 170.2 Cancer code, self-reported: sarcoma/fibrosarcoma Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 50 0.7 0.000449367 0.0828 0.496 0.471-0.522 OR 1.91 0.976-3.73 1.91 0.976-3.73 1.69 1.02-2.79 1.69 1.02-2.79 1.1 0.751-1.62 1.1 0.751-1.62 1.21 0.921-1.59 1.21 0.921-1.59 0.891 0.724-1.1 0.891 0.724-1.1 0.909 0.71-1.16 0.451 1.05 0.83-1.34 0.667 0.873 0.68-1.12 0.286 FALSE FALSE FALSE FALSE Both 551 5496 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode170-2-c3-connective-soft-nas-p-5e-05-mgi-20200608 prsweb-phecode170-2-c3-connective-soft-nas-p-5e-05-mgi-20200608 PRSWEB_PHECODE170.2_C3-CONNECTIVE-SOFT-NAS_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE170.2_C3-CONNECTIVE-SOFT-NAS_P_5e-05_MGI_20200608 170.2 Malignant neoplasm of other connective and soft tissue Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 74 0.75 0.000185237 0.0828 0.499 0.473-0.523 OR 1.16 0.511-2.65 1.16 0.511-2.65 0.943 0.497-1.79 0.943 0.497-1.79 1.07 0.721-1.58 1.07 0.721-1.58 1.1 0.834-1.46 1.1 0.834-1.46 1.04 0.854-1.27 1.04 0.854-1.27 1.08 0.843-1.38 0.55 0.953 0.74-1.23 0.705 1.05 0.818-1.34 0.72 FALSE FALSE FALSE FALSE Both 551 5496 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode170-2-c3-mestothel-softtissue-p-5e-05-mgi-20200608 prsweb-phecode170-2-c3-mestothel-softtissue-p-5e-05-mgi-20200608 PRSWEB_PHECODE170.2_C3-MESTOTHEL-SOFTTISSUE_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE170.2_C3-MESTOTHEL-SOFTTISSUE_P_5e-05_MGI_20200608 170.2 Melignant neoplasm of mesothelium and soft tissue Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 83 0.72 0.000461847 0.0828 0.499 0.473-0.524 OR 0.803 0.304-2.12 0.803 0.304-2.12 0.578 0.26-1.28 0.578 0.26-1.28 1.03 0.694-1.53 1.03 0.694-1.53 1.23 0.94-1.62 1.23 0.94-1.62 0.968 0.79-1.19 0.968 0.79-1.19 1.11 0.869-1.43 0.394 1.1 0.858-1.41 0.451 1.04 0.806-1.33 0.778 FALSE FALSE FALSE FALSE Both 551 5496 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode170-2-ukbb-saige-hrc-x170-2-p-5e-05-mgi-20200608 prsweb-phecode170-2-ukbb-saige-hrc-x170-2-p-5e-05-mgi-20200608 PRSWEB_PHECODE170.2_UKBB-SAIGE-HRC-X170.2_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE170.2_UKBB-SAIGE-HRC-X170.2_P_5e-05_MGI_20200608 170.2 Cancer of connective tissue Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 86 0.067 3.73779e-05 0.0827 0.513 0.487-0.539 OR 1.73 0.858-3.47 1.73 0.858-3.47 1.59 0.951-2.66 1.59 0.951-2.66 1.07 0.726-1.59 1.07 0.726-1.59 1.07 0.803-1.42 1.07 0.803-1.42 1.11 0.907-1.35 1.11 0.907-1.35 1.09 0.843-1.4 0.523 1.12 0.873-1.44 0.37 1.18 0.92-1.51 0.191 FALSE FALSE FALSE FALSE Both 551 5496 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode170-2-c3-connective-soft-nas-p-5e-06-mgi-20200608 prsweb-phecode170-2-c3-connective-soft-nas-p-5e-06-mgi-20200608 PRSWEB_PHECODE170.2_C3-CONNECTIVE-SOFT-NAS_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE170.2_C3-CONNECTIVE-SOFT-NAS_P_5e-06_MGI_20200608 170.2 Malignant neoplasm of other connective and soft tissue Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 11 0.97 0.000840518 0.0828 0.49 0.464-0.516 OR 1.35 0.625-2.93 1.35 0.625-2.93 1.41 0.821-2.42 1.41 0.821-2.42 1.11 0.753-1.62 1.11 0.753-1.62 0.963 0.717-1.29 0.963 0.717-1.29 1.03 0.846-1.26 1.03 0.846-1.26 0.792 0.617-1.02 0.069 0.942 0.74-1.2 0.625 0.94 0.739-1.2 0.616 FALSE FALSE FALSE FALSE Both 551 5496 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode170-2-ukbb-saige-hrc-x170-2-p-5e-06-mgi-20200608 prsweb-phecode170-2-ukbb-saige-hrc-x170-2-p-5e-06-mgi-20200608 PRSWEB_PHECODE170.2_UKBB-SAIGE-HRC-X170.2_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE170.2_UKBB-SAIGE-HRC-X170.2_P_5e-06_MGI_20200608 170.2 Cancer of connective tissue Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 11 0.56 0.000329924 0.0828 0.474 0.45-0.5 OR 1.16 0.51-2.65 1.16 0.51-2.65 1.6 0.956-2.67 1.6 0.956-2.67 1.27 0.878-1.83 1.27 0.878-1.83 0.986 0.735-1.32 0.986 0.735-1.32 0.967 0.789-1.18 0.967 0.789-1.18 1.04 0.81-1.33 0.76 1.12 0.879-1.44 0.35 1.02 0.789-1.31 0.906 FALSE FALSE FALSE FALSE Both 551 5496 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode170-2-20001-1068-pt-mgi-20200608 prsweb-phecode170-2-20001-1068-pt-mgi-20200608 PRSWEB_PHECODE170.2_20001-1068_PT_MGI_20200608 P&T PRSWEB_PHECODE170.2_20001-1068_PT_MGI_20200608 170.2 Cancer code, self-reported: sarcoma/fibrosarcoma Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative P&T UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 61 0.87 0.000503207 0.0828 0.495 0.47-0.522 OR 1.72 0.853-3.45 1.72 0.853-3.45 1.04 0.56-1.92 1.04 0.56-1.92 1.11 0.754-1.63 1.11 0.754-1.63 0.982 0.733-1.32 0.982 0.733-1.32 0.946 0.771-1.16 0.946 0.771-1.16 0.868 0.678-1.11 0.26 0.96 0.754-1.22 0.738 0.894 0.7-1.14 0.371 FALSE FALSE FALSE FALSE Both 551 5496 GRCh37/hg19 P<=6.31e-05 2020-06-08 prsweb-phecode170-2-c3-connective-soft-nas-pt-mgi-20200608 prsweb-phecode170-2-c3-connective-soft-nas-pt-mgi-20200608 PRSWEB_PHECODE170.2_C3-CONNECTIVE-SOFT-NAS_PT_MGI_20200608 P&T PRSWEB_PHECODE170.2_C3-CONNECTIVE-SOFT-NAS_PT_MGI_20200608 170.2 Malignant neoplasm of other connective and soft tissue Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative P&T UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 12 0.95 0.00143421 0.0828 0.49 0.464-0.516 OR 2.09 1.1-3.99 2.09 1.1-3.99 1.6 0.957-2.67 1.6 0.957-2.67 1.11 0.755-1.63 1.11 0.755-1.63 1 0.75-1.34 1 0.75-1.34 0.93 0.757-1.14 0.93 0.757-1.14 0.91 0.711-1.16 0.455 0.993 0.78-1.26 0.952 0.9 0.703-1.15 0.405 FALSE FALSE FALSE FALSE Both 551 5496 GRCh37/hg19 P<=6.31e-06 2020-06-08 prsweb-phecode170-2-ukbb-saige-hrc-x170-2-pt-mgi-20200608 prsweb-phecode170-2-ukbb-saige-hrc-x170-2-pt-mgi-20200608 PRSWEB_PHECODE170.2_UKBB-SAIGE-HRC-X170.2_PT_MGI_20200608 P&T PRSWEB_PHECODE170.2_UKBB-SAIGE-HRC-X170.2_PT_MGI_20200608 170.2 Cancer of connective tissue Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative P&T UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 6 0.58 0.000996014 0.0828 0.456 0.435-0.477 OR 1.35 0.623-2.92 1.35 0.623-2.92 1.51 0.889-2.55 1.51 0.889-2.55 1.32 0.937-1.86 1.32 0.937-1.86 0.984 0.734-1.32 0.984 0.734-1.32 1.1 0.904-1.34 1.1 0.904-1.34 1.07 0.73-1.56 0.733 0.892 0.605-1.31 0.561 1.14 0.782-1.67 0.492 FALSE FALSE FALSE FALSE Both 551 5496 GRCh37/hg19 P<=1.26e-06 2020-06-08 prsweb-phecode170-2-20001-1068-prs-cs-mgi-20200608 prsweb-phecode170-2-20001-1068-prs-cs-mgi-20200608 PRSWEB_PHECODE170.2_20001-1068_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE170.2_20001-1068_PRS-CS_MGI_20200608 170.2 Cancer code, self-reported: sarcoma/fibrosarcoma Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative PRS-CS UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 971543 0.21 8.01915e-05 0.0828 0.517 0.493-0.542 OR 1.53 0.736-3.19 1.53 0.736-3.19 1.22 0.689-2.17 1.22 0.689-2.17 1.11 0.754-1.63 1.11 0.754-1.63 1.17 0.886-1.54 1.17 0.886-1.54 1.08 0.881-1.31 1.08 0.881-1.31 0.982 0.763-1.27 0.89 1.11 0.865-1.42 0.421 1.12 0.874-1.43 0.373 FALSE FALSE FALSE FALSE Both 551 5496 GRCh37/hg19 auto 2020-06-08 prsweb-phecode170-2-c49-prs-cs-mgi-20200608 prsweb-phecode170-2-c49-prs-cs-mgi-20200608 PRSWEB_PHECODE170.2_C49_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE170.2_C49_PRS-CS_MGI_20200608 170.2 Diagnoses - main ICD10: C49 Malignant neoplasm of other connective and soft tissue Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative PRS-CS UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1002162 0.97 4.81457e-05 0.0828 0.504 0.48-0.53 OR 0.448 0.125-1.61 0.448 0.125-1.61 0.673 0.319-1.42 0.673 0.319-1.42 0.922 0.608-1.4 0.922 0.608-1.4 0.944 0.701-1.27 0.944 0.701-1.27 1.08 0.889-1.32 1.08 0.889-1.32 0.845 0.657-1.09 0.19 0.983 0.771-1.25 0.893 1.02 0.802-1.3 0.865 FALSE FALSE FALSE FALSE Both 551 5496 GRCh37/hg19 auto 2020-06-08 prsweb-phecode170-2-20001-1068-lassosum-mgi-20200608 prsweb-phecode170-2-20001-1068-lassosum-mgi-20200608 PRSWEB_PHECODE170.2_20001-1068_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE170.2_20001-1068_LASSOSUM_MGI_20200608 170.2 Cancer code, self-reported: sarcoma/fibrosarcoma Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative lassosum UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1494911 0.18 0.000392953 0.0828 0.514 0.489-0.539 OR 1.9 0.97-3.71 1.9 0.97-3.71 1.69 1.02-2.79 1.69 1.02-2.79 1.38 0.971-1.97 1.38 0.971-1.97 1.17 0.887-1.54 1.17 0.887-1.54 1.16 0.952-1.41 1.16 0.952-1.41 1.31 1.03-1.68 0.0307 0.962 0.739-1.25 0.774 1.27 0.988-1.63 0.0619 FALSE FALSE FALSE FALSE Both 551 5496 GRCh37/hg19 s=1;Lambda=0.02976 2020-06-08 prsweb-phecode170-2-c49-lassosum-mgi-20200608 prsweb-phecode170-2-c49-lassosum-mgi-20200608 PRSWEB_PHECODE170.2_C49_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE170.2_C49_LASSOSUM_MGI_20200608 170.2 Diagnoses - main ICD10: C49 Malignant neoplasm of other connective and soft tissue Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative lassosum UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 394653 0.57 0.000648993 0.0828 0.506 0.482-0.532 OR 1.17 0.514-2.66 1.17 0.514-2.66 1.31 0.753-2.29 1.31 0.753-2.29 1.27 0.88-1.83 1.27 0.88-1.83 1.3 0.996-1.7 1.3 0.996-1.7 0.995 0.813-1.22 0.995 0.813-1.22 1.11 0.863-1.42 0.424 1.1 0.86-1.41 0.439 1.06 0.828-1.37 0.627 FALSE FALSE FALSE FALSE Both 551 5496 GRCh37/hg19 s=0.2;Lambda=0.01833 2020-06-08 prsweb-phecode170-2-ukbb-saige-hrc-x170-2-lassosum-mgi-20200608 prsweb-phecode170-2-ukbb-saige-hrc-x170-2-lassosum-mgi-20200608 PRSWEB_PHECODE170.2_UKBB-SAIGE-HRC-X170.2_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE170.2_UKBB-SAIGE-HRC-X170.2_LASSOSUM_MGI_20200608 170.2 Cancer of connective tissue Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative lassosum UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 534767 0.5 0.00167596 0.0828 0.511 0.486-0.535 OR 0.807 0.306-2.13 0.807 0.306-2.13 0.582 0.262-1.29 0.582 0.262-1.29 0.844 0.548-1.3 0.844 0.548-1.3 0.865 0.636-1.18 0.865 0.636-1.18 1.16 0.958-1.42 1.16 0.958-1.42 0.932 0.725-1.2 0.584 0.974 0.759-1.25 0.833 1.12 0.883-1.43 0.342 FALSE FALSE FALSE FALSE Both 551 5496 GRCh37/hg19 s=1;Lambda=0.04833 2020-06-08 prsweb-phecode172-20001-1003-p-5e-05-mgi-20200608 prsweb-phecode172-20001-1003-p-5e-05-mgi-20200608 PRSWEB_PHECODE172_20001-1003_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE172_20001-1003_P_5e-05_MGI_20200608 172 Cancer code, self-reported: skin cancer Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 132 0.00018 0.00190573 0.148 0.515 0.504-0.526 OR 1.31 0.925-1.86 1.31 0.925-1.86 1.27 0.988-1.64 1.27 0.988-1.64 1.23 1.04-1.44 1.23 1.04-1.44 1.17 1.04-1.33 1.17 1.04-1.33 1.14 1.04-1.24 1.14 1.04-1.24 1.12 1.01-1.26 0.037 1.12 1-1.25 0.045 1.23 1.11-1.37 0.000154 TRUE FALSE FALSE FALSE Both 3557 14050 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode172-c3-skin-p-5e-05-mgi-20200608 prsweb-phecode172-c3-skin-p-5e-05-mgi-20200608 PRSWEB_PHECODE172_C3-SKIN_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE172_C3-SKIN_P_5e-05_MGI_20200608 172 Malignant neoplasm of skin Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 433 9.4e-56 0.0244054 0.146 0.586 0.576-0.597 OR 2.48 1.84-3.34 2.48 1.84-3.34 2.04 1.64-2.55 2.04 1.64-2.55 1.76 1.52-2.05 1.76 1.52-2.05 1.84 1.64-2.05 1.84 1.64-2.05 1.72 1.59-1.87 1.72 1.59-1.87 1.27 1.12-1.43 0.000132 1.58 1.41-1.78 1.44e-14 2.2 1.96-2.46 4.39e-43 TRUE FALSE FALSE FALSE Both 3557 14050 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode172-ukbb-saige-hrc-x172-p-5e-05-mgi-20200608 prsweb-phecode172-ukbb-saige-hrc-x172-p-5e-05-mgi-20200608 PRSWEB_PHECODE172_UKBB-SAIGE-HRC-X172_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE172_UKBB-SAIGE-HRC-X172_P_5e-05_MGI_20200608 172 Skin cancer Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 365 4.7e-61 0.0266946 0.146 0.591 0.581-0.603 OR 1.97 1.46-2.67 1.97 1.46-2.67 2.07 1.66-2.58 2.07 1.66-2.58 2 1.73-2.31 2 1.73-2.31 1.95 1.75-2.18 1.95 1.75-2.18 1.81 1.67-1.97 1.81 1.67-1.97 1.3 1.15-1.47 2.05e-05 1.58 1.4-1.77 5.7e-14 2.34 2.09-2.62 2.2e-49 TRUE FALSE FALSE FALSE Both 3557 14050 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode172-20001-1003-p-5e-06-mgi-20200608 prsweb-phecode172-20001-1003-p-5e-06-mgi-20200608 PRSWEB_PHECODE172_20001-1003_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE172_20001-1003_P_5e-06_MGI_20200608 172 Cancer code, self-reported: skin cancer Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 15 1.2e-07 0.00232263 0.148 0.509 0.499-0.52 OR 1.52 1.08-2.14 1.52 1.08-2.14 1.28 0.996-1.65 1.28 0.996-1.65 1.21 1.03-1.43 1.21 1.03-1.43 1.16 1.03-1.31 1.16 1.03-1.31 1.17 1.07-1.27 1.17 1.07-1.27 1.15 1.03-1.29 0.0143 1.24 1.11-1.39 0.000129 1.33 1.19-1.48 4.32e-07 TRUE FALSE FALSE FALSE Both 3557 14050 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode172-c3-skin-p-5e-06-mgi-20200608 prsweb-phecode172-c3-skin-p-5e-06-mgi-20200608 PRSWEB_PHECODE172_C3-SKIN_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE172_C3-SKIN_P_5e-06_MGI_20200608 172 Malignant neoplasm of skin Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 208 3.7e-51 0.0233344 0.146 0.583 0.572-0.593 OR 2.04 1.5-2.79 2.04 1.5-2.79 1.88 1.5-2.36 1.88 1.5-2.36 1.81 1.56-2.1 1.81 1.56-2.1 1.74 1.56-1.95 1.74 1.56-1.95 1.69 1.56-1.84 1.69 1.56-1.84 1.23 1.09-1.38 0.000951 1.57 1.4-1.77 2.5e-14 2.13 1.91-2.39 7.02e-40 TRUE FALSE FALSE FALSE Both 3557 14050 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode172-ukbb-saige-hrc-x172-p-5e-06-mgi-20200608 prsweb-phecode172-ukbb-saige-hrc-x172-p-5e-06-mgi-20200608 PRSWEB_PHECODE172_UKBB-SAIGE-HRC-X172_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE172_UKBB-SAIGE-HRC-X172_P_5e-06_MGI_20200608 172 Skin cancer Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 159 4.1e-58 0.0262667 0.146 0.586 0.576-0.597 OR 2.06 1.53-2.77 2.06 1.53-2.77 2.36 1.91-2.92 2.36 1.91-2.92 2.12 1.84-2.44 2.12 1.84-2.44 1.9 1.7-2.12 1.9 1.7-2.12 1.76 1.62-1.91 1.76 1.62-1.91 1.24 1.1-1.4 0.000417 1.56 1.39-1.75 1.09e-13 2.24 2-2.5 2.07e-44 TRUE FALSE FALSE FALSE Both 3557 14050 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode172-20001-1003-p-5e-07-mgi-20200608 prsweb-phecode172-20001-1003-p-5e-07-mgi-20200608 PRSWEB_PHECODE172_20001-1003_P_5e-07_MGI_20200608 P_5e-07 PRSWEB_PHECODE172_20001-1003_P_5e-07_MGI_20200608 172 Cancer code, self-reported: skin cancer Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-07) UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 5 7.4e-10 0.00276979 0.148 0.5 0.489-0.511 OR 1.56 1.12-2.16 1.56 1.12-2.16 1.44 1.13-1.83 1.44 1.13-1.83 1.23 1.05-1.45 1.23 1.05-1.45 1.33 1.18-1.5 1.33 1.18-1.5 1.2 1.1-1.31 1.2 1.1-1.31 1.17 1.05-1.31 0.00608 1.15 1.03-1.29 0.0123 1.33 1.2-1.49 2.26e-07 TRUE FALSE FALSE FALSE Both 3557 14050 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode172-c3-skin-p-5e-07-mgi-20200608 prsweb-phecode172-c3-skin-p-5e-07-mgi-20200608 PRSWEB_PHECODE172_C3-SKIN_P_5e-07_MGI_20200608 P_5e-07 PRSWEB_PHECODE172_C3-SKIN_P_5e-07_MGI_20200608 172 Malignant neoplasm of skin Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-07) UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 135 5.3e-51 0.022078 0.146 0.582 0.571-0.593 OR 2.02 1.48-2.76 2.02 1.48-2.76 2.08 1.67-2.59 2.08 1.67-2.59 1.96 1.7-2.27 1.96 1.7-2.27 1.73 1.55-1.94 1.73 1.55-1.94 1.69 1.55-1.83 1.69 1.55-1.83 1.32 1.17-1.49 5.98e-06 1.6 1.42-1.8 4.03e-15 2.2 1.96-2.46 2.12e-42 TRUE FALSE FALSE FALSE Both 3557 14050 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode172-ukbb-saige-hrc-x172-p-5e-07-mgi-20200608 prsweb-phecode172-ukbb-saige-hrc-x172-p-5e-07-mgi-20200608 PRSWEB_PHECODE172_UKBB-SAIGE-HRC-X172_P_5e-07_MGI_20200608 P_5e-07 PRSWEB_PHECODE172_UKBB-SAIGE-HRC-X172_P_5e-07_MGI_20200608 172 Skin cancer Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative Fixed threshold (5e-07) UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 105 2.3e-58 0.0251403 0.146 0.585 0.575-0.596 OR 2.17 1.62-2.92 2.17 1.62-2.92 2.31 1.87-2.86 2.31 1.87-2.86 2.17 1.88-2.5 2.17 1.88-2.5 1.95 1.75-2.17 1.95 1.75-2.17 1.76 1.62-1.91 1.76 1.62-1.91 1.15 1.02-1.3 0.0227 1.51 1.35-1.7 2.61e-12 2.16 1.93-2.41 6.17e-42 TRUE FALSE FALSE FALSE Both 3557 14050 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode172-c3-skin-p-5e-09-mgi-20200608 prsweb-phecode172-c3-skin-p-5e-09-mgi-20200608 PRSWEB_PHECODE172_C3-SKIN_P_5e-09_MGI_20200608 P_5e-09 PRSWEB_PHECODE172_C3-SKIN_P_5e-09_MGI_20200608 172 Malignant neoplasm of skin Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-09) UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 78 1.2e-49 0.0203658 0.146 0.58 0.569-0.591 OR 2.45 1.82-3.29 2.45 1.82-3.29 1.99 1.6-2.49 1.99 1.6-2.49 1.91 1.65-2.21 1.91 1.65-2.21 1.77 1.58-1.97 1.77 1.58-1.97 1.65 1.52-1.8 1.65 1.52-1.8 1.25 1.11-1.41 0.000259 1.57 1.4-1.76 3.5e-14 2.1 1.88-2.35 1.92e-38 TRUE FALSE FALSE FALSE Both 3557 14050 GRCh37/hg19 P<=5e-09 2020-06-08 prsweb-phecode172-ukbb-saige-hrc-x172-p-5e-09-mgi-20200608 prsweb-phecode172-ukbb-saige-hrc-x172-p-5e-09-mgi-20200608 PRSWEB_PHECODE172_UKBB-SAIGE-HRC-X172_P_5e-09_MGI_20200608 P_5e-09 PRSWEB_PHECODE172_UKBB-SAIGE-HRC-X172_P_5e-09_MGI_20200608 172 Skin cancer Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative Fixed threshold (5e-09) UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 60 2.4e-53 0.0215002 0.146 0.58 0.57-0.59 OR 2.68 2.02-3.55 2.68 2.02-3.55 2.27 1.83-2.8 2.27 1.83-2.8 2.07 1.8-2.4 2.07 1.8-2.4 1.86 1.67-2.08 1.86 1.67-2.08 1.63 1.5-1.77 1.63 1.5-1.77 1.15 1.02-1.29 0.0236 1.54 1.37-1.73 1.51e-13 2.01 1.8-2.25 5.58e-35 TRUE FALSE FALSE FALSE Both 3557 14050 GRCh37/hg19 P<=5e-09 2020-06-08 prsweb-phecode172-c3-skin-p-5e-08-mgi-20200608 prsweb-phecode172-c3-skin-p-5e-08-mgi-20200608 PRSWEB_PHECODE172_C3-SKIN_P_5e-08_MGI_20200608 P_5e-08 PRSWEB_PHECODE172_C3-SKIN_P_5e-08_MGI_20200608 172 Malignant neoplasm of skin Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative GWAS Hits UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 95 2.9e-50 0.021721 0.146 0.581 0.57-0.592 OR 2.2 1.63-2.98 2.2 1.63-2.98 2.06 1.65-2.57 2.06 1.65-2.57 1.94 1.68-2.25 1.94 1.68-2.25 1.74 1.56-1.94 1.74 1.56-1.94 1.68 1.55-1.83 1.68 1.55-1.83 1.2 1.06-1.35 0.00329 1.61 1.43-1.81 6.97e-16 2.14 1.91-2.39 4.33e-40 TRUE FALSE FALSE TRUE Both 3557 14050 GRCh37/hg19 P<=5e-08 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000400/ScoringFiles/ phewas/PRSWEB_PHECODE172_C3-SKIN_P_5e-08_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE172_C3-SKIN_P_5e-08_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode172-ukbb-saige-hrc-x172-p-5e-08-mgi-20200608 prsweb-phecode172-ukbb-saige-hrc-x172-p-5e-08-mgi-20200608 PRSWEB_PHECODE172_UKBB-SAIGE-HRC-X172_P_5e-08_MGI_20200608 P_5e-08 PRSWEB_PHECODE172_UKBB-SAIGE-HRC-X172_P_5e-08_MGI_20200608 172 Skin cancer Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative GWAS Hits UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 80 1.6e-57 0.0234904 0.146 0.584 0.574-0.594 OR 2.3 1.72-3.09 2.3 1.72-3.09 2.21 1.78-2.74 2.21 1.78-2.74 2.05 1.77-2.37 2.05 1.77-2.37 1.89 1.69-2.11 1.89 1.69-2.11 1.72 1.58-1.87 1.72 1.58-1.87 1.16 1.03-1.31 0.0154 1.54 1.37-1.73 2.41e-13 2.14 1.91-2.39 1.54e-40 TRUE FALSE FALSE TRUE Both 3557 14050 GRCh37/hg19 P<=5e-08 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000404/ScoringFiles/ phewas/PRSWEB_PHECODE172_UKBB-SAIGE-HRC-X172_P_5e-08_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE172_UKBB-SAIGE-HRC-X172_P_5e-08_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode172-20001-1003-pt-mgi-20200608 prsweb-phecode172-20001-1003-pt-mgi-20200608 PRSWEB_PHECODE172_20001-1003_PT_MGI_20200608 P&T PRSWEB_PHECODE172_20001-1003_PT_MGI_20200608 172 Cancer code, self-reported: skin cancer Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative P&T UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 6 9.9e-15 0.00493797 0.148 0.513 0.503-0.523 OR 1.56 1.12-2.16 1.56 1.12-2.16 1.29 1.01-1.65 1.29 1.01-1.65 1.42 1.21-1.66 1.42 1.21-1.66 1.36 1.2-1.52 1.36 1.2-1.52 1.3 1.19-1.41 1.3 1.19-1.41 1.17 1.04-1.31 0.00808 1.36 1.21-1.52 9.37e-08 1.53 1.37-1.7 4.4e-14 TRUE FALSE FALSE TRUE Both 3557 14050 GRCh37/hg19 P<=6.31e-07 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000399/ScoringFiles/ phewas/PRSWEB_PHECODE172_20001-1003_PT_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE172_20001-1003_PT_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode172-c3-skin-pt-mgi-20200608 prsweb-phecode172-c3-skin-pt-mgi-20200608 PRSWEB_PHECODE172_C3-SKIN_PT_MGI_20200608 P&T PRSWEB_PHECODE172_C3-SKIN_PT_MGI_20200608 172 Malignant neoplasm of skin Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative P&T UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 389 7.4e-56 0.0246682 0.146 0.586 0.576-0.597 OR 2.23 1.64-3.03 2.23 1.64-3.03 2.18 1.75-2.71 2.18 1.75-2.71 1.79 1.54-2.08 1.79 1.54-2.08 1.83 1.64-2.04 1.83 1.64-2.04 1.74 1.6-1.89 1.74 1.6-1.89 1.23 1.09-1.38 0.000978 1.56 1.39-1.76 5.79e-14 2.19 1.96-2.45 8.61e-43 TRUE FALSE FALSE TRUE Both 3557 14050 GRCh37/hg19 P<=3.98e-05 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000402/ScoringFiles/ phewas/PRSWEB_PHECODE172_C3-SKIN_PT_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE172_C3-SKIN_PT_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode172-ukbb-saige-hrc-x172-pt-mgi-20200608 prsweb-phecode172-ukbb-saige-hrc-x172-pt-mgi-20200608 PRSWEB_PHECODE172_UKBB-SAIGE-HRC-X172_PT_MGI_20200608 P&T PRSWEB_PHECODE172_UKBB-SAIGE-HRC-X172_PT_MGI_20200608 172 Skin cancer Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative P&T UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 292 3.8e-62 0.0274273 0.146 0.591 0.581-0.602 OR 2.51 1.89-3.34 2.51 1.89-3.34 2.17 1.74-2.69 2.17 1.74-2.69 2.03 1.76-2.35 2.03 1.76-2.35 1.92 1.72-2.15 1.92 1.72-2.15 1.77 1.63-1.92 1.77 1.63-1.92 1.28 1.13-1.45 6.33e-05 1.62 1.44-1.83 6.87e-16 2.31 2.07-2.59 1.01e-47 TRUE FALSE FALSE TRUE Both 3557 14050 GRCh37/hg19 P<=3.16e-05 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000406/ScoringFiles/ phewas/PRSWEB_PHECODE172_UKBB-SAIGE-HRC-X172_PT_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE172_UKBB-SAIGE-HRC-X172_PT_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode172-20001-1003-prs-cs-mgi-20200608 prsweb-phecode172-20001-1003-prs-cs-mgi-20200608 PRSWEB_PHECODE172_20001-1003_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE172_20001-1003_PRS-CS_MGI_20200608 172 Cancer code, self-reported: skin cancer Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative PRS-CS UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1103220 0.037 0.000959952 0.148 0.51 0.499-0.521 OR 1.7 1.22-2.38 1.7 1.22-2.38 1.44 1.12-1.84 1.44 1.12-1.84 1.14 0.967-1.35 1.14 0.967-1.35 1.1 0.969-1.24 1.1 0.969-1.24 1.1 1.01-1.2 1.1 1.01-1.2 1.06 0.948-1.18 0.32 1.01 0.906-1.13 0.852 1.12 1.01-1.25 0.0353 TRUE FALSE FALSE TRUE Both 3557 14050 GRCh37/hg19 auto https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000398/ScoringFiles/ phewas/PRSWEB_PHECODE172_20001-1003_PRS-CS_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE172_20001-1003_PRS-CS_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode172-c3-skin-prs-cs-mgi-20200608 prsweb-phecode172-c3-skin-prs-cs-mgi-20200608 PRSWEB_PHECODE172_C3-SKIN_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE172_C3-SKIN_PRS-CS_MGI_20200608 172 Malignant neoplasm of skin Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative PRS-CS UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1111490 2e-49 0.0231577 0.146 0.581 0.57-0.591 OR 2.25 1.67-3.03 2.25 1.67-3.03 2 1.61-2.5 2 1.61-2.5 1.82 1.57-2.11 1.82 1.57-2.11 1.81 1.62-2.02 1.81 1.62-2.02 1.69 1.55-1.83 1.69 1.55-1.83 1.21 1.07-1.36 0.00172 1.45 1.29-1.64 3.65e-10 2.07 1.85-2.32 3.73e-37 TRUE FALSE FALSE TRUE Both 3557 14050 GRCh37/hg19 auto https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000401/ScoringFiles/ phewas/PRSWEB_PHECODE172_C3-SKIN_PRS-CS_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE172_C3-SKIN_PRS-CS_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode172-ukbb-saige-hrc-x172-prs-cs-mgi-20200608 prsweb-phecode172-ukbb-saige-hrc-x172-prs-cs-mgi-20200608 PRSWEB_PHECODE172_UKBB-SAIGE-HRC-X172_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE172_UKBB-SAIGE-HRC-X172_PRS-CS_MGI_20200608 172 Skin cancer Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative PRS-CS UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1119238 1.8e-48 0.021109 0.146 0.58 0.57-0.591 OR 2.42 1.81-3.24 2.42 1.81-3.24 2.04 1.64-2.54 2.04 1.64-2.54 1.86 1.61-2.16 1.86 1.61-2.16 1.73 1.55-1.94 1.73 1.55-1.94 1.67 1.53-1.81 1.67 1.53-1.81 1.33 1.18-1.5 3.5e-06 1.56 1.39-1.76 8.3e-14 2.15 1.92-2.41 2.64e-40 TRUE FALSE FALSE TRUE Both 3557 14050 GRCh37/hg19 auto https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000405/ScoringFiles/ phewas/PRSWEB_PHECODE172_UKBB-SAIGE-HRC-X172_PRS-CS_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE172_UKBB-SAIGE-HRC-X172_PRS-CS_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode172-20001-1003-lassosum-mgi-20200608 prsweb-phecode172-20001-1003-lassosum-mgi-20200608 PRSWEB_PHECODE172_20001-1003_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE172_20001-1003_LASSOSUM_MGI_20200608 172 Cancer code, self-reported: skin cancer Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. Quartile analysis was unavailable in the source output. MGI Michigan Genomics Initiative lassosum UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 6 2.2e-13 0.00487177 0.148 0.471 0.461-0.48 OR 1.57 1.13-2.17 1.57 1.13-2.17 1.47 1.16-1.87 1.47 1.16-1.87 1.51 1.3-1.77 1.51 1.3-1.77 1.51 1.35-1.69 1.51 1.35-1.69 1.25 1.15-1.36 1.25 1.15-1.36 TRUE FALSE FALSE FALSE Both 3557 14050 GRCh37/hg19 s=0.2;Lambda=0.07848 phewas/PRSWEB_PHECODE172_20001-1003_LASSOSUM_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE172_20001-1003_LASSOSUM_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode172-c3-skin-lassosum-mgi-20200608 prsweb-phecode172-c3-skin-lassosum-mgi-20200608 PRSWEB_PHECODE172_C3-SKIN_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE172_C3-SKIN_LASSOSUM_MGI_20200608 172 Malignant neoplasm of skin Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative lassosum UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 16316 1.4e-53 0.0218173 0.146 0.584 0.573-0.594 OR 1.65 1.2-2.27 1.65 1.2-2.27 2.01 1.61-2.5 2.01 1.61-2.5 2.11 1.83-2.44 2.11 1.83-2.44 1.87 1.68-2.09 1.87 1.68-2.09 1.74 1.6-1.89 1.74 1.6-1.89 1.27 1.13-1.43 1e-04 1.51 1.35-1.7 3.94e-12 2.18 1.95-2.44 2.44e-42 TRUE FALSE FALSE TRUE Both 3557 14050 GRCh37/hg19 s=0.5;Lambda=0.01129 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000403/ScoringFiles/ phewas/PRSWEB_PHECODE172_C3-SKIN_LASSOSUM_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE172_C3-SKIN_LASSOSUM_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode172-ukbb-saige-hrc-x172-lassosum-mgi-20200608 prsweb-phecode172-ukbb-saige-hrc-x172-lassosum-mgi-20200608 PRSWEB_PHECODE172_UKBB-SAIGE-HRC-X172_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE172_UKBB-SAIGE-HRC-X172_LASSOSUM_MGI_20200608 172 Skin cancer Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative lassosum UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 3166 3.1e-60 0.0256112 0.146 0.586 0.575-0.597 OR 2.26 1.69-3.03 2.26 1.69-3.03 2.41 1.95-2.97 2.41 1.95-2.97 2.11 1.83-2.43 2.11 1.83-2.43 1.98 1.78-2.21 1.98 1.78-2.21 1.77 1.63-1.92 1.77 1.63-1.92 1.16 1.03-1.31 0.0147 1.47 1.3-1.65 1.22e-10 2.15 1.92-2.4 1.17e-41 TRUE FALSE FALSE TRUE Both 3557 14050 GRCh37/hg19 s=0.2;Lambda=0.01438 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000407/ScoringFiles/ phewas/PRSWEB_PHECODE172_UKBB-SAIGE-HRC-X172_LASSOSUM_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE172_UKBB-SAIGE-HRC-X172_LASSOSUM_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode172-1-20001-1059-p-5e-05-mgi-20200608 prsweb-phecode172-1-20001-1059-p-5e-05-mgi-20200608 PRSWEB_PHECODE172.1_20001-1059_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE172.1_20001-1059_P_5e-05_MGI_20200608 172.1 Cancer code, self-reported: malignant melanoma Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 129 6e-18 0.00792626 0.0962 0.565 0.549-0.582 OR 1.61 1.01-2.59 1.61 1.01-2.59 1.63 1.16-2.29 1.63 1.16-2.29 1.69 1.36-2.11 1.69 1.36-2.11 1.9 1.63-2.23 1.9 1.63-2.23 1.58 1.4-1.79 1.58 1.4-1.79 1.23 1.03-1.47 0.0225 1.4 1.17-1.67 0.000165 1.91 1.61-2.25 2.33e-14 TRUE FALSE FALSE FALSE Both 1325 10649 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode172-1-c3-melanoma-skin-p-5e-05-mgi-20200608 prsweb-phecode172-1-c3-melanoma-skin-p-5e-05-mgi-20200608 PRSWEB_PHECODE172.1_C3-MELANOMA-SKIN_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE172.1_C3-MELANOMA-SKIN_P_5e-05_MGI_20200608 172.1 Malignant melanoma of skin Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 153 2.2e-25 0.0102907 0.0959 0.577 0.562-0.593 OR 2.4 1.59-3.63 2.4 1.59-3.63 2.33 1.73-3.14 2.33 1.73-3.14 2 1.63-2.46 2 1.63-2.46 1.77 1.51-2.08 1.77 1.51-2.08 1.73 1.53-1.95 1.73 1.53-1.95 1.21 1.01-1.45 0.0397 1.46 1.22-1.74 3.05e-05 2.09 1.77-2.48 4.09e-18 TRUE FALSE FALSE FALSE Both 1325 10649 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode172-1-c43-p-5e-05-mgi-20200608 prsweb-phecode172-1-c43-p-5e-05-mgi-20200608 PRSWEB_PHECODE172.1_C43_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE172.1_C43_P_5e-05_MGI_20200608 172.1 Diagnoses - main ICD10: C43 Malignant melanoma of skin Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 164 5.1e-17 0.00751794 0.0963 0.566 0.55-0.583 OR 1.66 1.04-2.66 1.66 1.04-2.66 1.87 1.35-2.57 1.87 1.35-2.57 1.65 1.33-2.06 1.65 1.33-2.06 1.53 1.3-1.81 1.53 1.3-1.81 1.5 1.33-1.7 1.5 1.33-1.7 1.27 1.06-1.52 0.00878 1.49 1.25-1.77 7.3e-06 1.88 1.59-2.22 2.05e-13 TRUE FALSE FALSE FALSE Both 1325 10649 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode172-1-d03-p-5e-05-mgi-20200608 prsweb-phecode172-1-d03-p-5e-05-mgi-20200608 PRSWEB_PHECODE172.1_D03_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE172.1_D03_P_5e-05_MGI_20200608 172.1 Diagnoses - main ICD10: D03 Melanoma in situ Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 95 0.65 0.000227263 0.0969 0.498 0.482-0.516 OR 0.87 0.47-1.61 0.87 0.47-1.61 1.14 0.767-1.68 1.14 0.767-1.68 1.16 0.9-1.48 1.16 0.9-1.48 1.07 0.884-1.29 1.07 0.884-1.29 0.987 0.864-1.13 0.987 0.864-1.13 1.02 0.871-1.2 0.771 1.02 0.871-1.2 0.774 1 0.851-1.18 0.979 FALSE FALSE FALSE FALSE Both 1325 10649 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode172-1-gwas-catalog-r2019-05-03-x172-1-p-5e-05-mgi-20200608 prsweb-phecode172-1-gwas-catalog-r2019-05-03-x172-1-p-5e-05-mgi-20200608 PRSWEB_PHECODE172.1_GWAS-Catalog-r2019-05-03-X172.1_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE172.1_GWAS-Catalog-r2019-05-03-X172.1_P_5e-05_MGI_20200608 172.1 Melanoma;Cutaneous malignant melanoma Binary 33 unique SNPs MGI Michigan Genomics Initiative Fixed threshold (5e-05) GWAS Catalog (2019-05-03) 18488026;19578364;21983785;21983787;23455637;26237428;28212542 https://www.ncbi.nlm.nih.gov/pubmed/?term=18488026+19578364+21983785+21983787+23455637+26237428+28212542 29 2.4e-39 0.0286498 0.0954 0.608 0.592-0.623 OR 2.93 2-4.3 2.93 2-4.3 2.8 2.11-3.7 2.8 2.11-3.7 1.94 1.57-2.38 1.94 1.57-2.38 1.86 1.59-2.18 1.86 1.59-2.18 1.89 1.67-2.13 1.89 1.67-2.13 1.34 1.1-1.62 0.00342 1.85 1.54-2.22 4.13e-11 2.65 2.23-3.16 1.12e-27 TRUE FALSE FALSE FALSE Both 1325 10649 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode172-1-melanoma-ransohoff-p-5e-05-mgi-20200608 prsweb-phecode172-1-melanoma-ransohoff-p-5e-05-mgi-20200608 PRSWEB_PHECODE172.1_Melanoma-Ransohoff_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE172.1_Melanoma-Ransohoff_P_5e-05_MGI_20200608 172.1 Melanomas of skin, dx or hx Binary known and novel MGI Michigan Genomics Initiative Fixed threshold (5e-05) Ransohoff KJ et al. 2017 28212542 https://www.ncbi.nlm.nih.gov/pubmed/?term=28212542 20 1.2e-34 0.0294901 0.0955 0.601 0.585-0.617 OR 2.54 1.7-3.8 2.54 1.7-3.8 2.78 2.1-3.69 2.78 2.1-3.69 2.16 1.77-2.64 2.16 1.77-2.64 1.88 1.6-2.2 1.88 1.6-2.2 1.61 1.43-1.82 1.61 1.43-1.82 1.24 1.02-1.51 0.0291 2.04 1.71-2.44 3.81e-15 2.34 1.97-2.8 2.66e-21 TRUE FALSE FALSE FALSE Both 1325 10649 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode172-1-ukbb-saige-hrc-x172-1-p-5e-05-mgi-20200608 prsweb-phecode172-1-ukbb-saige-hrc-x172-1-p-5e-05-mgi-20200608 PRSWEB_PHECODE172.1_UKBB-SAIGE-HRC-X172.1_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE172.1_UKBB-SAIGE-HRC-X172.1_P_5e-05_MGI_20200608 172.1 Melanomas of skin, dx or hx Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 138 3.9e-28 0.0116317 0.0959 0.586 0.571-0.602 OR 2.14 1.4-3.26 2.14 1.4-3.26 1.94 1.41-2.66 1.94 1.41-2.66 1.65 1.33-2.06 1.65 1.33-2.06 1.89 1.61-2.21 1.89 1.61-2.21 1.68 1.49-1.9 1.68 1.49-1.9 1.37 1.14-1.65 0.000972 1.71 1.43-2.05 4.39e-09 2.26 1.9-2.68 1.36e-20 TRUE FALSE FALSE FALSE Both 1325 10649 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode172-1-20001-1059-p-5e-06-mgi-20200608 prsweb-phecode172-1-20001-1059-p-5e-06-mgi-20200608 PRSWEB_PHECODE172.1_20001-1059_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE172.1_20001-1059_P_5e-06_MGI_20200608 172.1 Cancer code, self-reported: malignant melanoma Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 29 6.7e-30 0.0132182 0.0958 0.579 0.564-0.596 OR 1.81 1.16-2.84 1.81 1.16-2.84 2.15 1.58-2.92 2.15 1.58-2.92 2.31 1.9-2.82 2.31 1.9-2.82 2.08 1.78-2.42 2.08 1.78-2.42 1.73 1.54-1.96 1.73 1.54-1.96 1.25 1.04-1.51 0.018 1.61 1.34-1.92 1.66e-07 2.23 1.88-2.64 1.44e-20 TRUE FALSE FALSE FALSE Both 1325 10649 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode172-1-c3-melanoma-skin-p-5e-06-mgi-20200608 prsweb-phecode172-1-c3-melanoma-skin-p-5e-06-mgi-20200608 PRSWEB_PHECODE172.1_C3-MELANOMA-SKIN_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE172.1_C3-MELANOMA-SKIN_P_5e-06_MGI_20200608 172.1 Malignant melanoma of skin Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 42 7.9e-32 0.0156177 0.0957 0.584 0.568-0.6 OR 2.49 1.66-3.71 2.49 1.66-3.71 2.61 1.96-3.47 2.61 1.96-3.47 2.08 1.7-2.56 2.08 1.7-2.56 2.06 1.77-2.41 2.06 1.77-2.41 1.8 1.59-2.03 1.8 1.59-2.03 1.21 1.01-1.46 0.0426 1.54 1.29-1.84 1.86e-06 2.26 1.91-2.67 2.14e-21 TRUE FALSE FALSE FALSE Both 1325 10649 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode172-1-c43-p-5e-06-mgi-20200608 prsweb-phecode172-1-c43-p-5e-06-mgi-20200608 PRSWEB_PHECODE172.1_C43_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE172.1_C43_P_5e-06_MGI_20200608 172.1 Diagnoses - main ICD10: C43 Malignant melanoma of skin Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 37 5.3e-32 0.0122799 0.0957 0.587 0.571-0.604 OR 1.84 1.17-2.9 1.84 1.17-2.9 2.25 1.67-3.03 2.25 1.67-3.03 2 1.63-2.46 2 1.63-2.46 2.19 1.88-2.55 2.19 1.88-2.55 1.8 1.6-2.03 1.8 1.6-2.03 1.17 0.975-1.41 0.0912 1.56 1.31-1.86 8.19e-07 2.23 1.89-2.64 4.84e-21 TRUE FALSE FALSE FALSE Both 1325 10649 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode172-1-gwas-catalog-r2019-05-03-x172-1-p-5e-06-mgi-20200608 prsweb-phecode172-1-gwas-catalog-r2019-05-03-x172-1-p-5e-06-mgi-20200608 PRSWEB_PHECODE172.1_GWAS-Catalog-r2019-05-03-X172.1_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE172.1_GWAS-Catalog-r2019-05-03-X172.1_P_5e-06_MGI_20200608 172.1 Melanoma;Cutaneous malignant melanoma Binary 33 unique SNPs MGI Michigan Genomics Initiative Fixed threshold (5e-06) GWAS Catalog (2019-05-03) 18488026;19578364;21983785;21983787;23455637;26237428;28212542 https://www.ncbi.nlm.nih.gov/pubmed/?term=18488026+19578364+21983785+21983787+23455637+26237428+28212542 29 2.4e-39 0.0286498 0.0954 0.608 0.592-0.623 OR 2.93 2-4.3 2.93 2-4.3 2.8 2.11-3.7 2.8 2.11-3.7 1.94 1.57-2.38 1.94 1.57-2.38 1.86 1.59-2.18 1.86 1.59-2.18 1.89 1.67-2.13 1.89 1.67-2.13 1.34 1.1-1.62 0.00342 1.85 1.54-2.22 4.13e-11 2.65 2.23-3.16 1.12e-27 TRUE FALSE FALSE FALSE Both 1325 10649 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode172-1-melanoma-ransohoff-p-5e-06-mgi-20200608 prsweb-phecode172-1-melanoma-ransohoff-p-5e-06-mgi-20200608 PRSWEB_PHECODE172.1_Melanoma-Ransohoff_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE172.1_Melanoma-Ransohoff_P_5e-06_MGI_20200608 172.1 Melanomas of skin, dx or hx Binary known and novel MGI Michigan Genomics Initiative Fixed threshold (5e-06) Ransohoff KJ et al. 2017 28212542 https://www.ncbi.nlm.nih.gov/pubmed/?term=28212542 20 1.2e-34 0.0294901 0.0955 0.601 0.585-0.617 OR 2.54 1.7-3.8 2.54 1.7-3.8 2.78 2.1-3.69 2.78 2.1-3.69 2.16 1.77-2.64 2.16 1.77-2.64 1.88 1.6-2.2 1.88 1.6-2.2 1.61 1.43-1.82 1.61 1.43-1.82 1.24 1.02-1.51 0.0291 2.04 1.71-2.44 3.81e-15 2.34 1.97-2.8 2.66e-21 TRUE FALSE FALSE FALSE Both 1325 10649 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode172-1-ukbb-saige-hrc-x172-1-p-5e-06-mgi-20200608 prsweb-phecode172-1-ukbb-saige-hrc-x172-1-p-5e-06-mgi-20200608 PRSWEB_PHECODE172.1_UKBB-SAIGE-HRC-X172.1_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE172.1_UKBB-SAIGE-HRC-X172.1_P_5e-06_MGI_20200608 172.1 Melanomas of skin, dx or hx Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 34 2.1e-37 0.0181253 0.0955 0.596 0.58-0.613 OR 2.21 1.45-3.37 2.21 1.45-3.37 2.43 1.81-3.26 2.43 1.81-3.26 2.2 1.8-2.68 2.2 1.8-2.68 2.14 1.84-2.5 2.14 1.84-2.5 1.99 1.77-2.25 1.99 1.77-2.25 1.37 1.13-1.65 0.00113 1.54 1.28-1.85 4.99e-06 2.6 2.19-3.08 1.12e-27 TRUE FALSE FALSE FALSE Both 1325 10649 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode172-1-20001-1059-p-5e-07-mgi-20200608 prsweb-phecode172-1-20001-1059-p-5e-07-mgi-20200608 PRSWEB_PHECODE172.1_20001-1059_P_5e-07_MGI_20200608 P_5e-07 PRSWEB_PHECODE172.1_20001-1059_P_5e-07_MGI_20200608 172.1 Cancer code, self-reported: malignant melanoma Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-07) UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 14 2.1e-33 0.0141906 0.0956 0.58 0.565-0.597 OR 2.48 1.66-3.7 2.48 1.66-3.7 2.36 1.75-3.18 2.36 1.75-3.18 2.29 1.87-2.79 2.29 1.87-2.79 2.07 1.77-2.42 2.07 1.77-2.42 1.81 1.6-2.04 1.81 1.6-2.04 1.33 1.11-1.61 0.0026 1.63 1.36-1.95 1.11e-07 2.39 2.02-2.84 1.7e-23 TRUE FALSE FALSE FALSE Both 1325 10649 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode172-1-c3-melanoma-skin-p-5e-07-mgi-20200608 prsweb-phecode172-1-c3-melanoma-skin-p-5e-07-mgi-20200608 PRSWEB_PHECODE172.1_C3-MELANOMA-SKIN_P_5e-07_MGI_20200608 P_5e-07 PRSWEB_PHECODE172.1_C3-MELANOMA-SKIN_P_5e-07_MGI_20200608 172.1 Malignant melanoma of skin Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-07) UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 22 5.2e-38 0.0163732 0.0954 0.592 0.577-0.608 OR 2.83 1.92-4.18 2.83 1.92-4.18 2.58 1.94-3.44 2.58 1.94-3.44 2.27 1.86-2.76 2.27 1.86-2.76 2.2 1.89-2.56 2.2 1.89-2.56 2.03 1.8-2.29 2.03 1.8-2.29 1.01 0.832-1.22 0.95 1.42 1.19-1.7 8.99e-05 2.32 1.97-2.73 9.1e-24 TRUE FALSE FALSE FALSE Both 1325 10649 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode172-1-c43-p-5e-07-mgi-20200608 prsweb-phecode172-1-c43-p-5e-07-mgi-20200608 PRSWEB_PHECODE172.1_C43_P_5e-07_MGI_20200608 P_5e-07 PRSWEB_PHECODE172.1_C43_P_5e-07_MGI_20200608 172.1 Diagnoses - main ICD10: C43 Malignant melanoma of skin Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-07) UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 14 5.2e-39 0.0144363 0.0954 0.594 0.579-0.609 OR 2.58 1.73-3.84 2.58 1.73-3.84 2.4 1.78-3.22 2.4 1.78-3.22 2.3 1.88-2.8 2.3 1.88-2.8 2.19 1.88-2.55 2.19 1.88-2.55 1.89 1.67-2.13 1.89 1.67-2.13 1.52 1.26-1.84 1.6e-05 1.81 1.51-2.18 3.7e-10 2.75 2.3-3.28 3.07e-29 TRUE FALSE FALSE FALSE Both 1325 10649 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode172-1-gwas-catalog-r2019-05-03-x172-1-p-5e-07-mgi-20200608 prsweb-phecode172-1-gwas-catalog-r2019-05-03-x172-1-p-5e-07-mgi-20200608 PRSWEB_PHECODE172.1_GWAS-Catalog-r2019-05-03-X172.1_P_5e-07_MGI_20200608 P_5e-07 PRSWEB_PHECODE172.1_GWAS-Catalog-r2019-05-03-X172.1_P_5e-07_MGI_20200608 172.1 Melanoma;Cutaneous malignant melanoma Binary 33 unique SNPs MGI Michigan Genomics Initiative Fixed threshold (5e-07) GWAS Catalog (2019-05-03) 18488026;19578364;21983785;21983787;23455637;26237428;28212542 https://www.ncbi.nlm.nih.gov/pubmed/?term=18488026+19578364+21983785+21983787+23455637+26237428+28212542 27 4.8e-38 0.0282683 0.0954 0.606 0.589-0.621 OR 2.59 1.74-3.86 2.59 1.74-3.86 2.36 1.76-3.18 2.36 1.76-3.18 2.14 1.75-2.62 2.14 1.75-2.62 1.89 1.62-2.22 1.89 1.62-2.22 1.88 1.67-2.12 1.88 1.67-2.12 1.48 1.22-1.8 7.23e-05 1.87 1.55-2.25 4.74e-11 2.75 2.3-3.29 5.77e-29 TRUE FALSE FALSE FALSE Both 1325 10649 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode172-1-melanoma-ransohoff-p-5e-07-mgi-20200608 prsweb-phecode172-1-melanoma-ransohoff-p-5e-07-mgi-20200608 PRSWEB_PHECODE172.1_Melanoma-Ransohoff_P_5e-07_MGI_20200608 P_5e-07 PRSWEB_PHECODE172.1_Melanoma-Ransohoff_P_5e-07_MGI_20200608 172.1 Melanomas of skin, dx or hx Binary known and novel MGI Michigan Genomics Initiative Fixed threshold (5e-07) Ransohoff KJ et al. 2017 28212542 https://www.ncbi.nlm.nih.gov/pubmed/?term=28212542 20 1.2e-34 0.0294901 0.0955 0.601 0.585-0.617 OR 2.54 1.7-3.8 2.54 1.7-3.8 2.78 2.1-3.69 2.78 2.1-3.69 2.16 1.77-2.64 2.16 1.77-2.64 1.88 1.6-2.2 1.88 1.6-2.2 1.61 1.43-1.82 1.61 1.43-1.82 1.24 1.02-1.51 0.0291 2.04 1.71-2.44 3.81e-15 2.34 1.97-2.8 2.66e-21 TRUE FALSE FALSE FALSE Both 1325 10649 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode172-1-ukbb-saige-hrc-x172-1-p-5e-07-mgi-20200608 prsweb-phecode172-1-ukbb-saige-hrc-x172-1-p-5e-07-mgi-20200608 PRSWEB_PHECODE172.1_UKBB-SAIGE-HRC-X172.1_P_5e-07_MGI_20200608 P_5e-07 PRSWEB_PHECODE172.1_UKBB-SAIGE-HRC-X172.1_P_5e-07_MGI_20200608 172.1 Melanomas of skin, dx or hx Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative Fixed threshold (5e-07) UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 19 3.5e-43 0.0187653 0.0952 0.604 0.588-0.62 OR 2.68 1.81-3.98 2.68 1.81-3.98 2.5 1.87-3.35 2.5 1.87-3.35 2.53 2.09-3.06 2.53 2.09-3.06 2.28 1.96-2.65 2.28 1.96-2.65 1.94 1.72-2.19 1.94 1.72-2.19 1.38 1.13-1.67 0.00124 1.82 1.51-2.19 1.88e-10 2.73 2.3-3.26 2.16e-29 TRUE FALSE FALSE FALSE Both 1325 10649 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode172-1-20001-1059-p-5e-09-mgi-20200608 prsweb-phecode172-1-20001-1059-p-5e-09-mgi-20200608 PRSWEB_PHECODE172.1_20001-1059_P_5e-09_MGI_20200608 P_5e-09 PRSWEB_PHECODE172.1_20001-1059_P_5e-09_MGI_20200608 172.1 Cancer code, self-reported: malignant melanoma Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-09) UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 9 4.3e-33 0.0132507 0.0957 0.578 0.563-0.595 OR 2.21 1.45-3.35 2.21 1.45-3.35 2.46 1.83-3.3 2.46 1.83-3.3 2.31 1.9-2.82 2.31 1.9-2.82 2.06 1.77-2.41 2.06 1.77-2.41 1.7 1.51-1.92 1.7 1.51-1.92 1.28 1.06-1.54 0.00989 1.67 1.39-1.99 1.82e-08 2.25 1.9-2.67 1.07e-20 TRUE FALSE FALSE FALSE Both 1325 10649 GRCh37/hg19 P<=5e-09 2020-06-08 prsweb-phecode172-1-c3-melanoma-skin-p-5e-09-mgi-20200608 prsweb-phecode172-1-c3-melanoma-skin-p-5e-09-mgi-20200608 PRSWEB_PHECODE172.1_C3-MELANOMA-SKIN_P_5e-09_MGI_20200608 P_5e-09 PRSWEB_PHECODE172.1_C3-MELANOMA-SKIN_P_5e-09_MGI_20200608 172.1 Malignant melanoma of skin Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-09) UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 11 1.1e-38 0.0149737 0.0954 0.591 0.575-0.607 OR 2.91 1.99-4.26 2.91 1.99-4.26 3.04 2.31-3.99 3.04 2.31-3.99 2.24 1.84-2.73 2.24 1.84-2.73 2.05 1.76-2.39 2.05 1.76-2.39 1.92 1.71-2.17 1.92 1.71-2.17 1.42 1.17-1.71 0.000273 1.57 1.3-1.88 1.6e-06 2.58 2.17-3.07 3.16e-27 TRUE FALSE FALSE FALSE Both 1325 10649 GRCh37/hg19 P<=5e-09 2020-06-08 prsweb-phecode172-1-c43-p-5e-09-mgi-20200608 prsweb-phecode172-1-c43-p-5e-09-mgi-20200608 PRSWEB_PHECODE172.1_C43_P_5e-09_MGI_20200608 P_5e-09 PRSWEB_PHECODE172.1_C43_P_5e-09_MGI_20200608 172.1 Diagnoses - main ICD10: C43 Malignant melanoma of skin Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-09) UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 6 6.6e-31 0.0125318 0.0958 0.575 0.559-0.592 OR 2.26 1.49-3.43 2.26 1.49-3.43 2.27 1.68-3.06 2.27 1.68-3.06 1.96 1.59-2.42 1.96 1.59-2.42 1.85 1.58-2.17 1.85 1.58-2.17 1.85 1.64-2.09 1.85 1.64-2.09 1.12 0.93-1.35 0.23 1.51 1.27-1.8 4.61e-06 2.24 1.9-2.64 1.96e-21 TRUE FALSE FALSE FALSE Both 1325 10649 GRCh37/hg19 P<=5e-09 2020-06-08 prsweb-phecode172-1-gwas-catalog-r2019-05-03-x172-1-p-5e-09-mgi-20200608 prsweb-phecode172-1-gwas-catalog-r2019-05-03-x172-1-p-5e-09-mgi-20200608 PRSWEB_PHECODE172.1_GWAS-Catalog-r2019-05-03-X172.1_P_5e-09_MGI_20200608 P_5e-09 PRSWEB_PHECODE172.1_GWAS-Catalog-r2019-05-03-X172.1_P_5e-09_MGI_20200608 172.1 Melanoma;Cutaneous malignant melanoma Binary 33 unique SNPs MGI Michigan Genomics Initiative Fixed threshold (5e-09) GWAS Catalog (2019-05-03) 18488026;19578364;21983785;21983787;23455637;26237428;28212542 https://www.ncbi.nlm.nih.gov/pubmed/?term=18488026+19578364+21983785+21983787+23455637+26237428+28212542 12 3.5e-36 0.0252311 0.0954 0.598 0.582-0.614 OR 2.92 2-4.26 2.92 2-4.26 2.98 2.28-3.91 2.98 2.28-3.91 2.35 1.93-2.85 2.35 1.93-2.85 1.96 1.68-2.29 1.96 1.68-2.29 1.83 1.62-2.06 1.83 1.62-2.06 1.33 1.1-1.61 0.00335 1.73 1.44-2.07 3.88e-09 2.5 2.1-2.97 4.26e-25 TRUE FALSE FALSE FALSE Both 1325 10649 GRCh37/hg19 P<=5e-09 2020-06-08 prsweb-phecode172-1-melanoma-ransohoff-p-5e-09-mgi-20200608 prsweb-phecode172-1-melanoma-ransohoff-p-5e-09-mgi-20200608 PRSWEB_PHECODE172.1_Melanoma-Ransohoff_P_5e-09_MGI_20200608 P_5e-09 PRSWEB_PHECODE172.1_Melanoma-Ransohoff_P_5e-09_MGI_20200608 172.1 Melanomas of skin, dx or hx Binary known and novel MGI Michigan Genomics Initiative Fixed threshold (5e-09) Ransohoff KJ et al. 2017 28212542 https://www.ncbi.nlm.nih.gov/pubmed/?term=28212542 15 1.2e-35 0.0269493 0.0954 0.603 0.587-0.619 OR 3.18 2.2-4.61 3.18 2.2-4.61 3.06 2.34-4.01 3.06 2.34-4.01 2.33 1.91-2.84 2.33 1.91-2.84 1.89 1.62-2.22 1.89 1.62-2.22 1.9 1.68-2.14 1.9 1.68-2.14 1.27 1.05-1.54 0.0123 1.63 1.36-1.95 1.72e-07 2.48 2.09-2.95 4.71e-25 TRUE FALSE FALSE FALSE Both 1325 10649 GRCh37/hg19 P<=5e-09 2020-06-08 prsweb-phecode172-1-ukbb-saige-hrc-x172-1-p-5e-09-mgi-20200608 prsweb-phecode172-1-ukbb-saige-hrc-x172-1-p-5e-09-mgi-20200608 PRSWEB_PHECODE172.1_UKBB-SAIGE-HRC-X172.1_P_5e-09_MGI_20200608 P_5e-09 PRSWEB_PHECODE172.1_UKBB-SAIGE-HRC-X172.1_P_5e-09_MGI_20200608 172.1 Melanomas of skin, dx or hx Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative Fixed threshold (5e-09) UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 9 3.3e-37 0.0146047 0.0955 0.588 0.573-0.605 OR 2.82 1.92-4.14 2.82 1.92-4.14 2.49 1.86-3.33 2.49 1.86-3.33 2.26 1.85-2.76 2.26 1.85-2.76 2.03 1.74-2.37 2.03 1.74-2.37 1.75 1.55-1.97 1.75 1.55-1.97 1.35 1.12-1.64 0.00191 1.89 1.58-2.26 4.94e-12 2.47 2.08-2.94 2.34e-24 TRUE FALSE FALSE FALSE Both 1325 10649 GRCh37/hg19 P<=5e-09 2020-06-08 prsweb-phecode172-1-20001-1059-p-5e-08-mgi-20200608 prsweb-phecode172-1-20001-1059-p-5e-08-mgi-20200608 PRSWEB_PHECODE172.1_20001-1059_P_5e-08_MGI_20200608 P_5e-08 PRSWEB_PHECODE172.1_20001-1059_P_5e-08_MGI_20200608 172.1 Cancer code, self-reported: malignant melanoma Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative GWAS Hits UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 10 5.4e-32 0.0132834 0.0957 0.576 0.561-0.593 OR 2.25 1.48-3.42 2.25 1.48-3.42 2.49 1.86-3.34 2.49 1.86-3.34 2.32 1.9-2.82 2.32 1.9-2.82 2.16 1.85-2.51 2.16 1.85-2.51 1.68 1.48-1.89 1.68 1.48-1.89 1.12 0.927-1.34 0.247 1.54 1.3-1.83 1.11e-06 2.05 1.74-2.42 3.04e-17 TRUE FALSE FALSE TRUE Both 1325 10649 GRCh37/hg19 P<=5e-08 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000408/ScoringFiles/ phewas/PRSWEB_PHECODE172.1_20001-1059_P_5e-08_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE172.1_20001-1059_P_5e-08_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode172-1-c3-melanoma-skin-p-5e-08-mgi-20200608 prsweb-phecode172-1-c3-melanoma-skin-p-5e-08-mgi-20200608 PRSWEB_PHECODE172.1_C3-MELANOMA-SKIN_P_5e-08_MGI_20200608 P_5e-08 PRSWEB_PHECODE172.1_C3-MELANOMA-SKIN_P_5e-08_MGI_20200608 172.1 Malignant melanoma of skin Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative GWAS Hits UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 16 9.4e-35 0.0135386 0.0955 0.585 0.569-0.6 OR 3.26 2.26-4.7 3.26 2.26-4.7 2.66 2-3.52 2.66 2-3.52 2.12 1.73-2.59 2.12 1.73-2.59 2.05 1.76-2.39 2.05 1.76-2.39 1.89 1.68-2.13 1.89 1.68-2.13 1.27 1.05-1.53 0.0125 1.52 1.27-1.81 6.26e-06 2.39 2.02-2.83 3.78e-24 TRUE FALSE FALSE TRUE Both 1325 10649 GRCh37/hg19 P<=5e-08 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000412/ScoringFiles/ phewas/PRSWEB_PHECODE172.1_C3-MELANOMA-SKIN_P_5e-08_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE172.1_C3-MELANOMA-SKIN_P_5e-08_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode172-1-c43-p-5e-08-mgi-20200608 prsweb-phecode172-1-c43-p-5e-08-mgi-20200608 PRSWEB_PHECODE172.1_C43_P_5e-08_MGI_20200608 P_5e-08 PRSWEB_PHECODE172.1_C43_P_5e-08_MGI_20200608 172.1 Diagnoses - main ICD10: C43 Malignant melanoma of skin Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative GWAS Hits UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 9 5.2e-43 0.0173798 0.0952 0.598 0.582-0.613 OR 2.88 1.96-4.21 2.88 1.96-4.21 2.6 1.95-3.46 2.6 1.95-3.46 2.4 1.98-2.92 2.4 1.98-2.92 2.16 1.86-2.51 2.16 1.86-2.51 1.93 1.71-2.18 1.93 1.71-2.18 1.25 1.03-1.51 0.0253 1.8 1.5-2.16 1.85e-10 2.62 2.21-3.11 5.81e-28 TRUE FALSE FALSE TRUE Both 1325 10649 GRCh37/hg19 P<=5e-08 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000416/ScoringFiles/ phewas/PRSWEB_PHECODE172.1_C43_P_5e-08_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE172.1_C43_P_5e-08_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode172-1-gwas-catalog-r2019-05-03-x172-1-p-5e-08-mgi-20200608 prsweb-phecode172-1-gwas-catalog-r2019-05-03-x172-1-p-5e-08-mgi-20200608 PRSWEB_PHECODE172.1_GWAS-Catalog-r2019-05-03-X172.1_P_5e-08_MGI_20200608 P_5e-08 PRSWEB_PHECODE172.1_GWAS-Catalog-r2019-05-03-X172.1_P_5e-08_MGI_20200608 172.1 Melanoma;Cutaneous malignant melanoma Binary 33 unique SNPs MGI Michigan Genomics Initiative GWAS Hits GWAS Catalog (2019-05-03) 18488026;19578364;21983785;21983787;23455637;26237428;28212542 https://www.ncbi.nlm.nih.gov/pubmed/?term=18488026+19578364+21983785+21983787+23455637+26237428+28212542 18 1.3e-35 0.0272086 0.0955 0.6 0.584-0.616 OR 2.39 1.58-3.61 2.39 1.58-3.61 2.53 1.9-3.38 2.53 1.9-3.38 2.21 1.81-2.7 2.21 1.81-2.7 2.08 1.78-2.43 2.08 1.78-2.43 1.84 1.63-2.08 1.84 1.63-2.08 1.3 1.07-1.57 0.00723 1.68 1.4-2.02 2.05e-08 2.49 2.1-2.96 4.28e-25 TRUE FALSE FALSE TRUE Both 1325 10649 GRCh37/hg19 P<=5e-08 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000421/ScoringFiles/ phewas/PRSWEB_PHECODE172.1_GWAS-Catalog-r2019-05-03-X172.1_P_5e-08_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE172.1_GWAS-Catalog-r2019-05-03-X172.1_P_5e-08_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode172-1-melanoma-ransohoff-p-5e-08-mgi-20200608 prsweb-phecode172-1-melanoma-ransohoff-p-5e-08-mgi-20200608 PRSWEB_PHECODE172.1_Melanoma-Ransohoff_P_5e-08_MGI_20200608 P_5e-08 PRSWEB_PHECODE172.1_Melanoma-Ransohoff_P_5e-08_MGI_20200608 172.1 Melanomas of skin, dx or hx Binary known and novel MGI Michigan Genomics Initiative GWAS Hits Ransohoff KJ et al. 2017 28212542 https://www.ncbi.nlm.nih.gov/pubmed/?term=28212542 20 1.2e-34 0.0294901 0.0955 0.601 0.585-0.617 OR 2.54 1.7-3.8 2.54 1.7-3.8 2.78 2.1-3.69 2.78 2.1-3.69 2.16 1.77-2.64 2.16 1.77-2.64 1.88 1.6-2.2 1.88 1.6-2.2 1.61 1.43-1.82 1.61 1.43-1.82 1.24 1.02-1.51 0.0291 2.04 1.71-2.44 3.81e-15 2.34 1.97-2.8 2.66e-21 TRUE FALSE FALSE TRUE Both 1325 10649 GRCh37/hg19 P<=5e-08 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000425/ScoringFiles/ phewas/PRSWEB_PHECODE172.1_Melanoma-Ransohoff_P_5e-08_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE172.1_Melanoma-Ransohoff_P_5e-08_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode172-1-ukbb-saige-hrc-x172-1-p-5e-08-mgi-20200608 prsweb-phecode172-1-ukbb-saige-hrc-x172-1-p-5e-08-mgi-20200608 PRSWEB_PHECODE172.1_UKBB-SAIGE-HRC-X172.1_P_5e-08_MGI_20200608 P_5e-08 PRSWEB_PHECODE172.1_UKBB-SAIGE-HRC-X172.1_P_5e-08_MGI_20200608 172.1 Melanomas of skin, dx or hx Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative GWAS Hits UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 12 8e-47 0.0206972 0.0951 0.606 0.591-0.622 OR 2.62 1.77-3.88 2.62 1.77-3.88 2.95 2.24-3.89 2.95 2.24-3.89 2.55 2.1-3.09 2.55 2.1-3.09 2.29 1.97-2.66 2.29 1.97-2.66 1.91 1.69-2.15 1.91 1.69-2.15 1.47 1.2-1.79 0.000155 2.18 1.81-2.63 3.85e-16 2.95 2.46-3.54 7.57e-32 TRUE FALSE FALSE TRUE Both 1325 10649 GRCh37/hg19 P<=5e-08 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000429/ScoringFiles/ phewas/PRSWEB_PHECODE172.1_UKBB-SAIGE-HRC-X172.1_P_5e-08_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE172.1_UKBB-SAIGE-HRC-X172.1_P_5e-08_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode172-1-20001-1059-pt-mgi-20200608 prsweb-phecode172-1-20001-1059-pt-mgi-20200608 PRSWEB_PHECODE172.1_20001-1059_PT_MGI_20200608 P&T PRSWEB_PHECODE172.1_20001-1059_PT_MGI_20200608 172.1 Cancer code, self-reported: malignant melanoma Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative P&T UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 7 4.2e-35 0.0147874 0.0956 0.578 0.562-0.594 OR 2.65 1.79-3.93 2.65 1.79-3.93 2.27 1.68-3.07 2.27 1.68-3.07 2.31 1.9-2.82 2.31 1.9-2.82 2.19 1.88-2.55 2.19 1.88-2.55 1.7 1.51-1.92 1.7 1.51-1.92 1.29 1.07-1.56 0.00911 1.88 1.57-2.24 5.9e-12 2.37 1.99-2.81 1.92e-22 TRUE FALSE FALSE TRUE Both 1325 10649 GRCh37/hg19 P<=2e-11 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000410/ScoringFiles/ phewas/PRSWEB_PHECODE172.1_20001-1059_PT_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE172.1_20001-1059_PT_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode172-1-c3-melanoma-skin-pt-mgi-20200608 prsweb-phecode172-1-c3-melanoma-skin-pt-mgi-20200608 PRSWEB_PHECODE172.1_C3-MELANOMA-SKIN_PT_MGI_20200608 P&T PRSWEB_PHECODE172.1_C3-MELANOMA-SKIN_PT_MGI_20200608 172.1 Malignant melanoma of skin Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative P&T UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 21 4.9e-38 0.0166749 0.0954 0.593 0.576-0.609 OR 2.97 2.02-4.36 2.97 2.02-4.36 2.52 1.89-3.36 2.52 1.89-3.36 2.25 1.84-2.75 2.25 1.84-2.75 2.2 1.89-2.56 2.2 1.89-2.56 1.99 1.76-2.24 1.99 1.76-2.24 1.11 0.919-1.34 0.279 1.51 1.27-1.81 5.21e-06 2.41 2.04-2.85 4.43e-25 TRUE FALSE FALSE TRUE Both 1325 10649 GRCh37/hg19 P<=1.26e-07 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000414/ScoringFiles/ phewas/PRSWEB_PHECODE172.1_C3-MELANOMA-SKIN_PT_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE172.1_C3-MELANOMA-SKIN_PT_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode172-1-c43-pt-mgi-20200608 prsweb-phecode172-1-c43-pt-mgi-20200608 PRSWEB_PHECODE172.1_C43_PT_MGI_20200608 P&T PRSWEB_PHECODE172.1_C43_PT_MGI_20200608 172.1 Diagnoses - main ICD10: C43 Malignant melanoma of skin Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative P&T UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 9 5.2e-43 0.0173798 0.0952 0.598 0.582-0.613 OR 2.88 1.96-4.21 2.88 1.96-4.21 2.6 1.95-3.46 2.6 1.95-3.46 2.4 1.98-2.92 2.4 1.98-2.92 2.16 1.86-2.51 2.16 1.86-2.51 1.93 1.71-2.18 1.93 1.71-2.18 1.25 1.03-1.51 0.0253 1.8 1.5-2.16 1.85e-10 2.62 2.21-3.11 5.81e-28 TRUE FALSE FALSE TRUE Both 1325 10649 GRCh37/hg19 P<=5e-08 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000418/ScoringFiles/ phewas/PRSWEB_PHECODE172.1_C43_PT_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE172.1_C43_PT_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode172-1-d03-pt-mgi-20200608 prsweb-phecode172-1-d03-pt-mgi-20200608 PRSWEB_PHECODE172.1_D03_PT_MGI_20200608 P&T PRSWEB_PHECODE172.1_D03_PT_MGI_20200608 172.1 Diagnoses - main ICD10: D03 Melanoma in situ Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative P&T UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 147 0.027 0.000596512 0.0969 0.516 0.5-0.533 OR 1.07 0.603-1.9 1.07 0.603-1.9 1.17 0.788-1.73 1.17 0.788-1.73 1.14 0.887-1.47 1.14 0.887-1.47 1.13 0.939-1.36 1.13 0.939-1.36 1.14 1-1.3 1.14 1-1.3 1.06 0.897-1.25 0.499 1.07 0.903-1.26 0.452 1.18 1-1.39 0.0458 TRUE FALSE FALSE TRUE Both 1325 10649 GRCh37/hg19 P<=7.94e-05 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000420/ScoringFiles/ phewas/PRSWEB_PHECODE172.1_D03_PT_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE172.1_D03_PT_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode172-1-gwas-catalog-r2019-05-03-x172-1-pt-mgi-20200608 prsweb-phecode172-1-gwas-catalog-r2019-05-03-x172-1-pt-mgi-20200608 PRSWEB_PHECODE172.1_GWAS-Catalog-r2019-05-03-X172.1_PT_MGI_20200608 P&T PRSWEB_PHECODE172.1_GWAS-Catalog-r2019-05-03-X172.1_PT_MGI_20200608 172.1 Melanoma;Cutaneous malignant melanoma Binary 33 unique SNPs MGI Michigan Genomics Initiative P&T GWAS Catalog (2019-05-03) 18488026;19578364;21983785;21983787;23455637;26237428;28212542 https://www.ncbi.nlm.nih.gov/pubmed/?term=18488026+19578364+21983785+21983787+23455637+26237428+28212542 29 2.4e-39 0.0286498 0.0954 0.608 0.592-0.623 OR 2.93 2-4.3 2.93 2-4.3 2.8 2.11-3.7 2.8 2.11-3.7 1.94 1.57-2.38 1.94 1.57-2.38 1.86 1.59-2.18 1.86 1.59-2.18 1.89 1.67-2.13 1.89 1.67-2.13 1.34 1.1-1.62 0.00342 1.85 1.54-2.22 4.13e-11 2.65 2.23-3.16 1.12e-27 TRUE FALSE FALSE TRUE Both 1325 10649 GRCh37/hg19 P<=1e-06 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000423/ScoringFiles/ phewas/PRSWEB_PHECODE172.1_GWAS-Catalog-r2019-05-03-X172.1_PT_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE172.1_GWAS-Catalog-r2019-05-03-X172.1_PT_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode172-1-melanoma-ransohoff-pt-mgi-20200608 prsweb-phecode172-1-melanoma-ransohoff-pt-mgi-20200608 PRSWEB_PHECODE172.1_Melanoma-Ransohoff_PT_MGI_20200608 P&T PRSWEB_PHECODE172.1_Melanoma-Ransohoff_PT_MGI_20200608 172.1 Melanomas of skin, dx or hx Binary known and novel MGI Michigan Genomics Initiative P&T Ransohoff KJ et al. 2017 28212542 https://www.ncbi.nlm.nih.gov/pubmed/?term=28212542 20 1.2e-34 0.0294901 0.0955 0.601 0.585-0.617 OR 2.54 1.7-3.8 2.54 1.7-3.8 2.78 2.1-3.69 2.78 2.1-3.69 2.16 1.77-2.64 2.16 1.77-2.64 1.88 1.6-2.2 1.88 1.6-2.2 1.61 1.43-1.82 1.61 1.43-1.82 1.24 1.02-1.51 0.0291 2.04 1.71-2.44 3.81e-15 2.34 1.97-2.8 2.66e-21 TRUE FALSE FALSE TRUE Both 1325 10649 GRCh37/hg19 P<=3.5e-08 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000427/ScoringFiles/ phewas/PRSWEB_PHECODE172.1_Melanoma-Ransohoff_PT_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE172.1_Melanoma-Ransohoff_PT_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode172-1-ukbb-saige-hrc-x172-1-pt-mgi-20200608 prsweb-phecode172-1-ukbb-saige-hrc-x172-1-pt-mgi-20200608 PRSWEB_PHECODE172.1_UKBB-SAIGE-HRC-X172.1_PT_MGI_20200608 P&T PRSWEB_PHECODE172.1_UKBB-SAIGE-HRC-X172.1_PT_MGI_20200608 172.1 Melanomas of skin, dx or hx Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative P&T UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 15 9.1e-44 0.0210935 0.0952 0.604 0.587-0.62 OR 2.97 2.04-4.34 2.97 2.04-4.34 2.95 2.24-3.88 2.95 2.24-3.88 2.32 1.9-2.82 2.32 1.9-2.82 2.28 1.96-2.64 2.28 1.96-2.64 1.92 1.71-2.17 1.92 1.71-2.17 1.33 1.09-1.62 0.00443 1.92 1.6-2.31 2.92e-12 2.72 2.29-3.25 4.95e-29 TRUE FALSE FALSE TRUE Both 1325 10649 GRCh37/hg19 P<=2e-07 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000431/ScoringFiles/ phewas/PRSWEB_PHECODE172.1_UKBB-SAIGE-HRC-X172.1_PT_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE172.1_UKBB-SAIGE-HRC-X172.1_PT_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode172-1-20001-1059-prs-cs-mgi-20200608 prsweb-phecode172-1-20001-1059-prs-cs-mgi-20200608 PRSWEB_PHECODE172.1_20001-1059_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE172.1_20001-1059_PRS-CS_MGI_20200608 172.1 Cancer code, self-reported: malignant melanoma Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative PRS-CS UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1111490 1.8e-09 0.00512413 0.0966 0.547 0.531-0.563 OR 1.94 1.25-3.02 1.94 1.25-3.02 1.6 1.14-2.24 1.6 1.14-2.24 1.7 1.37-2.1 1.7 1.37-2.1 1.53 1.29-1.81 1.53 1.29-1.81 1.37 1.21-1.55 1.37 1.21-1.55 1.32 1.11-1.56 0.00147 1.16 0.975-1.38 0.0931 1.58 1.34-1.86 6.41e-08 TRUE FALSE FALSE TRUE Both 1325 10649 GRCh37/hg19 auto https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000409/ScoringFiles/ phewas/PRSWEB_PHECODE172.1_20001-1059_PRS-CS_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE172.1_20001-1059_PRS-CS_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode172-1-c3-melanoma-skin-prs-cs-mgi-20200608 prsweb-phecode172-1-c3-melanoma-skin-prs-cs-mgi-20200608 PRSWEB_PHECODE172.1_C3-MELANOMA-SKIN_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE172.1_C3-MELANOMA-SKIN_PRS-CS_MGI_20200608 172.1 Malignant melanoma of skin Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative PRS-CS UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1111490 4.6e-16 0.00825925 0.0964 0.568 0.552-0.584 OR 2.09 1.35-3.22 2.09 1.35-3.22 2.02 1.48-2.77 2.02 1.48-2.77 1.54 1.23-1.93 1.54 1.23-1.93 1.44 1.22-1.71 1.44 1.22-1.71 1.55 1.38-1.76 1.55 1.38-1.76 1.12 0.933-1.34 0.225 1.43 1.21-1.7 4.33e-05 1.84 1.56-2.17 5.7e-13 TRUE FALSE FALSE TRUE Both 1325 10649 GRCh37/hg19 auto https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000413/ScoringFiles/ phewas/PRSWEB_PHECODE172.1_C3-MELANOMA-SKIN_PRS-CS_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE172.1_C3-MELANOMA-SKIN_PRS-CS_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode172-1-c43-prs-cs-mgi-20200608 prsweb-phecode172-1-c43-prs-cs-mgi-20200608 PRSWEB_PHECODE172.1_C43_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE172.1_C43_PRS-CS_MGI_20200608 172.1 Diagnoses - main ICD10: C43 Malignant melanoma of skin Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative PRS-CS UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1109519 3e-12 0.00370256 0.0965 0.556 0.541-0.571 OR 1.88 1.2-2.95 1.88 1.2-2.95 1.56 1.11-2.19 1.56 1.11-2.19 1.51 1.21-1.9 1.51 1.21-1.9 1.55 1.31-1.83 1.55 1.31-1.83 1.43 1.26-1.62 1.43 1.26-1.62 1.21 1.02-1.44 0.0316 1.24 1.04-1.48 0.0142 1.63 1.38-1.92 5.38e-09 TRUE FALSE FALSE TRUE Both 1325 10649 GRCh37/hg19 auto https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000417/ScoringFiles/ phewas/PRSWEB_PHECODE172.1_C43_PRS-CS_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE172.1_C43_PRS-CS_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode172-1-d03-prs-cs-mgi-20200608 prsweb-phecode172-1-d03-prs-cs-mgi-20200608 PRSWEB_PHECODE172.1_D03_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE172.1_D03_PRS-CS_MGI_20200608 172.1 Diagnoses - main ICD10: D03 Melanoma in situ Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative PRS-CS UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1080882 0.16 0.00165781 0.0969 0.513 0.496-0.529 OR 1.18 0.697-2 1.18 0.697-2 1.15 0.785-1.68 1.15 0.785-1.68 0.981 0.753-1.28 0.981 0.753-1.28 1.04 0.865-1.26 1.04 0.865-1.26 1.01 0.884-1.15 1.01 0.884-1.15 1.07 0.907-1.26 0.422 1.16 0.988-1.37 0.0687 1.09 0.925-1.29 0.299 FALSE FALSE FALSE FALSE Both 1325 10649 GRCh37/hg19 auto 2020-06-08 prsweb-phecode172-1-ukbb-saige-hrc-x172-1-prs-cs-mgi-20200608 prsweb-phecode172-1-ukbb-saige-hrc-x172-1-prs-cs-mgi-20200608 PRSWEB_PHECODE172.1_UKBB-SAIGE-HRC-X172.1_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE172.1_UKBB-SAIGE-HRC-X172.1_PRS-CS_MGI_20200608 172.1 Melanomas of skin, dx or hx Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative PRS-CS UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1119238 2e-11 0.00690566 0.0965 0.555 0.54-0.573 OR 1.64 1.01-2.66 1.64 1.01-2.66 1.53 1.08-2.16 1.53 1.08-2.16 1.41 1.12-1.78 1.41 1.12-1.78 1.41 1.19-1.68 1.41 1.19-1.68 1.52 1.34-1.72 1.52 1.34-1.72 1.08 0.908-1.29 0.38 1.2 1.01-1.42 0.04 1.65 1.41-1.94 1.04e-09 TRUE FALSE FALSE TRUE Both 1325 10649 GRCh37/hg19 auto https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000430/ScoringFiles/ phewas/PRSWEB_PHECODE172.1_UKBB-SAIGE-HRC-X172.1_PRS-CS_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE172.1_UKBB-SAIGE-HRC-X172.1_PRS-CS_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode172-1-20001-1059-lassosum-mgi-20200608 prsweb-phecode172-1-20001-1059-lassosum-mgi-20200608 PRSWEB_PHECODE172.1_20001-1059_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE172.1_20001-1059_LASSOSUM_MGI_20200608 172.1 Cancer code, self-reported: malignant melanoma Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative lassosum UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 185 9.8e-34 0.0175399 0.0957 0.571 0.555-0.587 OR 2 1.29-3.09 2 1.29-3.09 2.34 1.74-3.14 2.34 1.74-3.14 2.23 1.83-2.73 2.23 1.83-2.73 2.07 1.77-2.42 2.07 1.77-2.42 1.86 1.65-2.1 1.86 1.65-2.1 1.29 1.07-1.56 0.00798 1.64 1.37-1.97 6.52e-08 2.43 2.05-2.88 1.83e-24 TRUE FALSE FALSE TRUE Both 1325 10649 GRCh37/hg19 s=0.2;Lambda=0.03793 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000411/ScoringFiles/ phewas/PRSWEB_PHECODE172.1_20001-1059_LASSOSUM_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE172.1_20001-1059_LASSOSUM_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode172-1-c3-melanoma-skin-lassosum-mgi-20200608 prsweb-phecode172-1-c3-melanoma-skin-lassosum-mgi-20200608 PRSWEB_PHECODE172.1_C3-MELANOMA-SKIN_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE172.1_C3-MELANOMA-SKIN_LASSOSUM_MGI_20200608 172.1 Malignant melanoma of skin Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative lassosum UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 505 6.5e-34 0.0175778 0.0957 0.578 0.562-0.595 OR 2.34 1.55-3.53 2.34 1.55-3.53 2.25 1.67-3.03 2.25 1.67-3.03 2.13 1.74-2.61 2.13 1.74-2.61 1.82 1.55-2.14 1.82 1.55-2.14 1.88 1.67-2.12 1.88 1.67-2.12 1.27 1.05-1.53 0.0146 1.64 1.37-1.96 8.49e-08 2.45 2.06-2.9 1.04e-24 TRUE FALSE FALSE TRUE Both 1325 10649 GRCh37/hg19 s=0.2;Lambda=0.03793 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000415/ScoringFiles/ phewas/PRSWEB_PHECODE172.1_C3-MELANOMA-SKIN_LASSOSUM_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE172.1_C3-MELANOMA-SKIN_LASSOSUM_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode172-1-c43-lassosum-mgi-20200608 prsweb-phecode172-1-c43-lassosum-mgi-20200608 PRSWEB_PHECODE172.1_C43_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE172.1_C43_LASSOSUM_MGI_20200608 172.1 Diagnoses - main ICD10: C43 Malignant melanoma of skin Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative lassosum UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 436 5.6e-29 0.0133171 0.0959 0.565 0.549-0.583 OR 1.93 1.24-3 1.93 1.24-3 2.16 1.59-2.93 2.16 1.59-2.93 2 1.63-2.46 2 1.63-2.46 1.79 1.53-2.1 1.79 1.53-2.1 1.73 1.53-1.95 1.73 1.53-1.95 1.18 0.973-1.42 0.0926 1.79 1.5-2.14 1.07e-10 2.28 1.92-2.7 3.47e-21 TRUE FALSE FALSE TRUE Both 1325 10649 GRCh37/hg19 s=0.5;Lambda=0.04833 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000419/ScoringFiles/ phewas/PRSWEB_PHECODE172.1_C43_LASSOSUM_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE172.1_C43_LASSOSUM_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode172-1-d03-lassosum-mgi-20200608 prsweb-phecode172-1-d03-lassosum-mgi-20200608 PRSWEB_PHECODE172.1_D03_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE172.1_D03_LASSOSUM_MGI_20200608 172.1 Diagnoses - main ICD10: D03 Melanoma in situ Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative lassosum UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 3838429 0.18 0.00201622 0.0969 0.512 0.496-0.528 OR 1.54 0.96-2.46 1.54 0.96-2.46 1.08 0.73-1.6 1.08 0.73-1.6 0.936 0.716-1.22 0.936 0.716-1.22 1.08 0.894-1.29 1.08 0.894-1.29 1.06 0.93-1.21 1.06 0.93-1.21 1.13 0.955-1.33 0.158 1.12 0.946-1.32 0.191 1.16 0.981-1.36 0.0827 FALSE FALSE FALSE FALSE Both 1325 10649 GRCh37/hg19 s=1;Lambda=0.006952 2020-06-08 prsweb-phecode172-1-ukbb-saige-hrc-x172-1-lassosum-mgi-20200608 prsweb-phecode172-1-ukbb-saige-hrc-x172-1-lassosum-mgi-20200608 PRSWEB_PHECODE172.1_UKBB-SAIGE-HRC-X172.1_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE172.1_UKBB-SAIGE-HRC-X172.1_LASSOSUM_MGI_20200608 172.1 Melanomas of skin, dx or hx Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative lassosum UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 296 1.1e-33 0.0185378 0.0957 0.582 0.566-0.599 OR 1.99 1.29-3.07 1.99 1.29-3.07 1.85 1.34-2.55 1.85 1.34-2.55 2.17 1.77-2.65 2.17 1.77-2.65 1.97 1.68-2.3 1.97 1.68-2.3 1.85 1.64-2.09 1.85 1.64-2.09 1.38 1.14-1.67 0.000856 1.79 1.49-2.15 4.19e-10 2.55 2.15-3.04 3.72e-26 TRUE FALSE FALSE TRUE Both 1325 10649 GRCh37/hg19 s=0.2;Lambda=0.03793 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000432/ScoringFiles/ phewas/PRSWEB_PHECODE172.1_UKBB-SAIGE-HRC-X172.1_LASSOSUM_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE172.1_UKBB-SAIGE-HRC-X172.1_LASSOSUM_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode172-1-gwas-catalog-r2019-05-03-x172-1-p-5e-05-ukb-20200608 prsweb-phecode172-1-gwas-catalog-r2019-05-03-x172-1-p-5e-05-ukb-20200608 PRSWEB_PHECODE172.1_GWAS-Catalog-r2019-05-03-X172.1_P_5e-05_UKB_20200608 P_5e-05 PRSWEB_PHECODE172.1_GWAS-Catalog-r2019-05-03-X172.1_P_5e-05_UKB_20200608 172.1 Melanoma;Cutaneous malignant melanoma Binary 33 unique SNPs UKB UK Biobank Fixed threshold (5e-05) GWAS Catalog (2019-05-03) 18488026;19578364;21983785;21983787;23455637;26237428;28212542 https://www.ncbi.nlm.nih.gov/pubmed/?term=18488026+19578364+21983785+21983787+23455637+26237428+28212542 29 2.8e-55 0.0230187 0.0812 0.622 0.607-0.637 OR 3.12 2.18-4.46 3.12 2.18-4.46 3.05 2.35-3.96 3.05 2.35-3.96 2.67 2.23-3.21 2.67 2.23-3.21 2.57 2.23-2.97 2.57 2.23-2.97 2.17 1.93-2.44 2.17 1.93-2.44 1.34 1.1-1.63 0.00315 1.82 1.51-2.19 2.73e-10 3.02 2.54-3.59 1.11e-35 TRUE FALSE FALSE FALSE Both 1317 13165 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode172-1-melanoma-ransohoff-p-5e-05-ukb-20200608 prsweb-phecode172-1-melanoma-ransohoff-p-5e-05-ukb-20200608 PRSWEB_PHECODE172.1_Melanoma-Ransohoff_P_5e-05_UKB_20200608 P_5e-05 PRSWEB_PHECODE172.1_Melanoma-Ransohoff_P_5e-05_UKB_20200608 172.1 Melanomas of skin, dx or hx Binary known and novel UKB UK Biobank Fixed threshold (5e-05) Ransohoff KJ et al. 2017 28212542 https://www.ncbi.nlm.nih.gov/pubmed/?term=28212542 20 7.9e-50 0.0193123 0.0813 0.62 0.604-0.635 OR 2.81 1.93-4.07 2.81 1.93-4.07 2.8 2.14-3.67 2.8 2.14-3.67 2.56 2.13-3.08 2.56 2.13-3.08 2.62 2.27-3.02 2.62 2.27-3.02 2.16 1.92-2.42 2.16 1.92-2.42 1.29 1.06-1.57 0.00947 1.7 1.41-2.04 1.81e-08 2.87 2.42-3.4 1.69e-33 TRUE FALSE FALSE FALSE Both 1317 13165 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode172-1-gwas-catalog-r2019-05-03-x172-1-p-5e-06-ukb-20200608 prsweb-phecode172-1-gwas-catalog-r2019-05-03-x172-1-p-5e-06-ukb-20200608 PRSWEB_PHECODE172.1_GWAS-Catalog-r2019-05-03-X172.1_P_5e-06_UKB_20200608 P_5e-06 PRSWEB_PHECODE172.1_GWAS-Catalog-r2019-05-03-X172.1_P_5e-06_UKB_20200608 172.1 Melanoma;Cutaneous malignant melanoma Binary 33 unique SNPs UKB UK Biobank Fixed threshold (5e-06) GWAS Catalog (2019-05-03) 18488026;19578364;21983785;21983787;23455637;26237428;28212542 https://www.ncbi.nlm.nih.gov/pubmed/?term=18488026+19578364+21983785+21983787+23455637+26237428+28212542 29 2.8e-55 0.0230187 0.0812 0.622 0.607-0.637 OR 3.12 2.18-4.46 3.12 2.18-4.46 3.05 2.35-3.96 3.05 2.35-3.96 2.67 2.23-3.21 2.67 2.23-3.21 2.57 2.23-2.97 2.57 2.23-2.97 2.17 1.93-2.44 2.17 1.93-2.44 1.34 1.1-1.63 0.00315 1.82 1.51-2.19 2.73e-10 3.02 2.54-3.59 1.11e-35 TRUE FALSE FALSE FALSE Both 1317 13165 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode172-1-melanoma-ransohoff-p-5e-06-ukb-20200608 prsweb-phecode172-1-melanoma-ransohoff-p-5e-06-ukb-20200608 PRSWEB_PHECODE172.1_Melanoma-Ransohoff_P_5e-06_UKB_20200608 P_5e-06 PRSWEB_PHECODE172.1_Melanoma-Ransohoff_P_5e-06_UKB_20200608 172.1 Melanomas of skin, dx or hx Binary known and novel UKB UK Biobank Fixed threshold (5e-06) Ransohoff KJ et al. 2017 28212542 https://www.ncbi.nlm.nih.gov/pubmed/?term=28212542 20 7.9e-50 0.0193123 0.0813 0.62 0.604-0.635 OR 2.81 1.93-4.07 2.81 1.93-4.07 2.8 2.14-3.67 2.8 2.14-3.67 2.56 2.13-3.08 2.56 2.13-3.08 2.62 2.27-3.02 2.62 2.27-3.02 2.16 1.92-2.42 2.16 1.92-2.42 1.29 1.06-1.57 0.00947 1.7 1.41-2.04 1.81e-08 2.87 2.42-3.4 1.69e-33 TRUE FALSE FALSE FALSE Both 1317 13165 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode172-1-gwas-catalog-r2019-05-03-x172-1-p-5e-07-ukb-20200608 prsweb-phecode172-1-gwas-catalog-r2019-05-03-x172-1-p-5e-07-ukb-20200608 PRSWEB_PHECODE172.1_GWAS-Catalog-r2019-05-03-X172.1_P_5e-07_UKB_20200608 P_5e-07 PRSWEB_PHECODE172.1_GWAS-Catalog-r2019-05-03-X172.1_P_5e-07_UKB_20200608 172.1 Melanoma;Cutaneous malignant melanoma Binary 33 unique SNPs UKB UK Biobank Fixed threshold (5e-07) GWAS Catalog (2019-05-03) 18488026;19578364;21983785;21983787;23455637;26237428;28212542 https://www.ncbi.nlm.nih.gov/pubmed/?term=18488026+19578364+21983785+21983787+23455637+26237428+28212542 27 3.3e-52 0.0233148 0.0812 0.619 0.603-0.634 OR 3.12 2.18-4.47 3.12 2.18-4.47 2.89 2.21-3.76 2.89 2.21-3.76 2.62 2.18-3.14 2.62 2.18-3.14 2.42 2.09-2.79 2.42 2.09-2.79 2.14 1.91-2.41 2.14 1.91-2.41 1.35 1.11-1.64 0.00243 1.77 1.47-2.13 1.8e-09 2.93 2.47-3.49 3.14e-34 TRUE FALSE FALSE FALSE Both 1317 13165 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode172-1-melanoma-ransohoff-p-5e-07-ukb-20200608 prsweb-phecode172-1-melanoma-ransohoff-p-5e-07-ukb-20200608 PRSWEB_PHECODE172.1_Melanoma-Ransohoff_P_5e-07_UKB_20200608 P_5e-07 PRSWEB_PHECODE172.1_Melanoma-Ransohoff_P_5e-07_UKB_20200608 172.1 Melanomas of skin, dx or hx Binary known and novel UKB UK Biobank Fixed threshold (5e-07) Ransohoff KJ et al. 2017 28212542 https://www.ncbi.nlm.nih.gov/pubmed/?term=28212542 20 7.9e-50 0.0193123 0.0813 0.62 0.604-0.635 OR 2.81 1.93-4.07 2.81 1.93-4.07 2.8 2.14-3.67 2.8 2.14-3.67 2.56 2.13-3.08 2.56 2.13-3.08 2.62 2.27-3.02 2.62 2.27-3.02 2.16 1.92-2.42 2.16 1.92-2.42 1.29 1.06-1.57 0.00947 1.7 1.41-2.04 1.81e-08 2.87 2.42-3.4 1.69e-33 TRUE FALSE FALSE FALSE Both 1317 13165 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode172-1-gwas-catalog-r2019-05-03-x172-1-p-5e-09-ukb-20200608 prsweb-phecode172-1-gwas-catalog-r2019-05-03-x172-1-p-5e-09-ukb-20200608 PRSWEB_PHECODE172.1_GWAS-Catalog-r2019-05-03-X172.1_P_5e-09_UKB_20200608 P_5e-09 PRSWEB_PHECODE172.1_GWAS-Catalog-r2019-05-03-X172.1_P_5e-09_UKB_20200608 172.1 Melanoma;Cutaneous malignant melanoma Binary 33 unique SNPs UKB UK Biobank Fixed threshold (5e-09) GWAS Catalog (2019-05-03) 18488026;19578364;21983785;21983787;23455637;26237428;28212542 https://www.ncbi.nlm.nih.gov/pubmed/?term=18488026+19578364+21983785+21983787+23455637+26237428+28212542 12 1.3e-39 0.0166576 0.0816 0.6 0.584-0.615 OR 2.65 1.81-3.88 2.65 1.81-3.88 2.27 1.7-3.03 2.27 1.7-3.03 2.34 1.94-2.83 2.34 1.94-2.83 2.29 1.98-2.65 2.29 1.98-2.65 1.84 1.64-2.07 1.84 1.64-2.07 1.33 1.1-1.61 0.00281 1.7 1.42-2.04 6.5e-09 2.47 2.08-2.93 2.25e-25 TRUE FALSE FALSE FALSE Both 1317 13165 GRCh37/hg19 P<=5e-09 2020-06-08 prsweb-phecode172-1-melanoma-ransohoff-p-5e-09-ukb-20200608 prsweb-phecode172-1-melanoma-ransohoff-p-5e-09-ukb-20200608 PRSWEB_PHECODE172.1_Melanoma-Ransohoff_P_5e-09_UKB_20200608 P_5e-09 PRSWEB_PHECODE172.1_Melanoma-Ransohoff_P_5e-09_UKB_20200608 172.1 Melanomas of skin, dx or hx Binary known and novel UKB UK Biobank Fixed threshold (5e-09) Ransohoff KJ et al. 2017 28212542 https://www.ncbi.nlm.nih.gov/pubmed/?term=28212542 15 7.1e-42 0.0164556 0.0815 0.61 0.593-0.624 OR 2.25 1.5-3.38 2.25 1.5-3.38 2.52 1.9-3.33 2.52 1.9-3.33 2.4 1.98-2.9 2.4 1.98-2.9 2.27 1.96-2.63 2.27 1.96-2.63 2.12 1.89-2.39 2.12 1.89-2.39 1.38 1.14-1.66 0.000825 1.47 1.22-1.77 4.78e-05 2.71 2.29-3.21 5.58e-31 TRUE FALSE FALSE FALSE Both 1317 13165 GRCh37/hg19 P<=5e-09 2020-06-08 prsweb-phecode172-1-gwas-catalog-r2019-05-03-x172-1-p-5e-08-ukb-20200608 prsweb-phecode172-1-gwas-catalog-r2019-05-03-x172-1-p-5e-08-ukb-20200608 PRSWEB_PHECODE172.1_GWAS-Catalog-r2019-05-03-X172.1_P_5e-08_UKB_20200608 P_5e-08 PRSWEB_PHECODE172.1_GWAS-Catalog-r2019-05-03-X172.1_P_5e-08_UKB_20200608 172.1 Melanoma;Cutaneous malignant melanoma Binary 33 unique SNPs UKB UK Biobank GWAS Hits GWAS Catalog (2019-05-03) 18488026;19578364;21983785;21983787;23455637;26237428;28212542 https://www.ncbi.nlm.nih.gov/pubmed/?term=18488026+19578364+21983785+21983787+23455637+26237428+28212542 18 5.1e-50 0.0200432 0.0813 0.615 0.599-0.63 OR 2.57 1.75-3.77 2.57 1.75-3.77 3.22 2.49-4.16 3.22 2.49-4.16 2.67 2.23-3.21 2.67 2.23-3.21 2.31 1.99-2.67 2.31 1.99-2.67 2.01 1.79-2.26 2.01 1.79-2.26 1.39 1.14-1.69 0.000981 1.88 1.56-2.26 2.2e-11 2.86 2.4-3.41 3.01e-32 TRUE FALSE FALSE TRUE Both 1317 13165 GRCh37/hg19 P<=5e-08 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000422/ScoringFiles/ phewas/PRSWEB_PHECODE172.1_GWAS-Catalog-r2019-05-03-X172.1_P_5e-08_UKB_20200608/all.tsv phewas/PRSWEB_PHECODE172.1_GWAS-Catalog-r2019-05-03-X172.1_P_5e-08_UKB_20200608/exclusion.tsv 2020-06-08 prsweb-phecode172-1-melanoma-ransohoff-p-5e-08-ukb-20200608 prsweb-phecode172-1-melanoma-ransohoff-p-5e-08-ukb-20200608 PRSWEB_PHECODE172.1_Melanoma-Ransohoff_P_5e-08_UKB_20200608 P_5e-08 PRSWEB_PHECODE172.1_Melanoma-Ransohoff_P_5e-08_UKB_20200608 172.1 Melanomas of skin, dx or hx Binary known and novel UKB UK Biobank GWAS Hits Ransohoff KJ et al. 2017 28212542 https://www.ncbi.nlm.nih.gov/pubmed/?term=28212542 20 7.9e-50 0.0193123 0.0813 0.62 0.604-0.635 OR 2.81 1.93-4.07 2.81 1.93-4.07 2.8 2.14-3.67 2.8 2.14-3.67 2.56 2.13-3.08 2.56 2.13-3.08 2.62 2.27-3.02 2.62 2.27-3.02 2.16 1.92-2.42 2.16 1.92-2.42 1.29 1.06-1.57 0.00947 1.7 1.41-2.04 1.81e-08 2.87 2.42-3.4 1.69e-33 TRUE FALSE FALSE TRUE Both 1317 13165 GRCh37/hg19 P<=5e-08 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000426/ScoringFiles/ phewas/PRSWEB_PHECODE172.1_Melanoma-Ransohoff_P_5e-08_UKB_20200608/all.tsv phewas/PRSWEB_PHECODE172.1_Melanoma-Ransohoff_P_5e-08_UKB_20200608/exclusion.tsv 2020-06-08 prsweb-phecode172-1-gwas-catalog-r2019-05-03-x172-1-pt-ukb-20200608 prsweb-phecode172-1-gwas-catalog-r2019-05-03-x172-1-pt-ukb-20200608 PRSWEB_PHECODE172.1_GWAS-Catalog-r2019-05-03-X172.1_PT_UKB_20200608 P&T PRSWEB_PHECODE172.1_GWAS-Catalog-r2019-05-03-X172.1_PT_UKB_20200608 172.1 Melanoma;Cutaneous malignant melanoma Binary 33 unique SNPs UKB UK Biobank P&T GWAS Catalog (2019-05-03) 18488026;19578364;21983785;21983787;23455637;26237428;28212542 https://www.ncbi.nlm.nih.gov/pubmed/?term=18488026+19578364+21983785+21983787+23455637+26237428+28212542 27 3.3e-52 0.0233148 0.0812 0.619 0.603-0.634 OR 3.12 2.18-4.47 3.12 2.18-4.47 2.89 2.21-3.76 2.89 2.21-3.76 2.62 2.18-3.14 2.62 2.18-3.14 2.42 2.09-2.79 2.42 2.09-2.79 2.14 1.91-2.41 2.14 1.91-2.41 1.35 1.11-1.64 0.00243 1.77 1.47-2.13 1.8e-09 2.93 2.47-3.49 3.14e-34 TRUE FALSE FALSE TRUE Both 1317 13165 GRCh37/hg19 P<=5e-07 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000424/ScoringFiles/ phewas/PRSWEB_PHECODE172.1_GWAS-Catalog-r2019-05-03-X172.1_PT_UKB_20200608/all.tsv phewas/PRSWEB_PHECODE172.1_GWAS-Catalog-r2019-05-03-X172.1_PT_UKB_20200608/exclusion.tsv 2020-06-08 prsweb-phecode172-1-melanoma-ransohoff-pt-ukb-20200608 prsweb-phecode172-1-melanoma-ransohoff-pt-ukb-20200608 PRSWEB_PHECODE172.1_Melanoma-Ransohoff_PT_UKB_20200608 P&T PRSWEB_PHECODE172.1_Melanoma-Ransohoff_PT_UKB_20200608 172.1 Melanomas of skin, dx or hx Binary known and novel UKB UK Biobank P&T Ransohoff KJ et al. 2017 28212542 https://www.ncbi.nlm.nih.gov/pubmed/?term=28212542 20 7.9e-50 0.0193123 0.0813 0.62 0.604-0.635 OR 2.81 1.93-4.07 2.81 1.93-4.07 2.8 2.14-3.67 2.8 2.14-3.67 2.56 2.13-3.08 2.56 2.13-3.08 2.62 2.27-3.02 2.62 2.27-3.02 2.16 1.92-2.42 2.16 1.92-2.42 1.29 1.06-1.57 0.00947 1.7 1.41-2.04 1.81e-08 2.87 2.42-3.4 1.69e-33 TRUE FALSE FALSE TRUE Both 1317 13165 GRCh37/hg19 P<=3.5e-08 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000428/ScoringFiles/ phewas/PRSWEB_PHECODE172.1_Melanoma-Ransohoff_PT_UKB_20200608/all.tsv phewas/PRSWEB_PHECODE172.1_Melanoma-Ransohoff_PT_UKB_20200608/exclusion.tsv 2020-06-08 prsweb-phecode172-2-20001-1060-p-5e-05-mgi-20200608 prsweb-phecode172-2-20001-1060-p-5e-05-mgi-20200608 PRSWEB_PHECODE172.2_20001-1060_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE172.2_20001-1060_P_5e-05_MGI_20200608 172.2 Cancer code, self-reported: non-melanoma skin cancer Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 112 0.51 7.0793e-05 0.139 0.501 0.49-0.513 OR 0.868 0.565-1.33 0.868 0.565-1.33 0.942 0.703-1.26 0.942 0.703-1.26 0.971 0.803-1.18 0.971 0.803-1.18 0.972 0.846-1.12 0.972 0.846-1.12 1.02 0.928-1.12 1.02 0.928-1.12 1.08 0.956-1.21 0.225 1.06 0.944-1.2 0.314 1.07 0.947-1.2 0.288 FALSE FALSE FALSE FALSE Both 2954 12944 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode172-2-c3-other-skin-p-5e-05-mgi-20200608 prsweb-phecode172-2-c3-other-skin-p-5e-05-mgi-20200608 PRSWEB_PHECODE172.2_C3-OTHER-SKIN_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE172.2_C3-OTHER-SKIN_P_5e-05_MGI_20200608 172.2 Other malignant neoplasms of skin Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 446 1.6e-45 0.0246508 0.137 0.584 0.572-0.597 OR 2.7 1.99-3.66 2.7 1.99-3.66 2.31 1.84-2.89 2.31 1.84-2.89 2.02 1.73-2.36 2.02 1.73-2.36 1.9 1.69-2.14 1.9 1.69-2.14 1.73 1.58-1.89 1.73 1.58-1.89 1.2 1.05-1.37 0.00569 1.43 1.26-1.62 2.67e-08 2.1 1.86-2.37 1.79e-33 TRUE FALSE FALSE FALSE Both 2954 12944 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode172-2-c44-p-5e-05-mgi-20200608 prsweb-phecode172-2-c44-p-5e-05-mgi-20200608 PRSWEB_PHECODE172.2_C44_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE172.2_C44_P_5e-05_MGI_20200608 172.2 Diagnoses - main ICD10: C44 Other malignant neoplasms of skin Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 321 3.7e-43 0.0232486 0.137 0.581 0.569-0.593 OR 2.05 1.46-2.86 2.05 1.46-2.86 1.99 1.57-2.52 1.99 1.57-2.52 1.91 1.63-2.23 1.91 1.63-2.23 1.84 1.63-2.07 1.84 1.63-2.07 1.67 1.53-1.83 1.67 1.53-1.83 1.28 1.13-1.46 0.000173 1.52 1.34-1.73 7.94e-11 2.12 1.87-2.39 6.27e-34 TRUE FALSE FALSE FALSE Both 2954 12944 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode172-2-ukbb-saige-hrc-x172-2-p-5e-05-mgi-20200608 prsweb-phecode172-2-ukbb-saige-hrc-x172-2-p-5e-05-mgi-20200608 PRSWEB_PHECODE172.2_UKBB-SAIGE-HRC-X172.2_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE172.2_UKBB-SAIGE-HRC-X172.2_P_5e-05_MGI_20200608 172.2 Other non-epithelial cancer of skin Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 367 1.8e-51 0.0267679 0.137 0.587 0.576-0.599 OR 3 2.23-4.04 3 2.23-4.04 2.46 1.96-3.08 2.46 1.96-3.08 2.27 1.95-2.63 2.27 1.95-2.63 2.09 1.86-2.35 2.09 1.86-2.35 1.73 1.58-1.89 1.73 1.58-1.89 1.28 1.12-1.46 0.000228 1.5 1.32-1.7 4.44e-10 2.19 1.94-2.48 1.44e-36 TRUE FALSE FALSE FALSE Both 2954 12944 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode172-2-20001-1060-p-5e-06-mgi-20200608 prsweb-phecode172-2-20001-1060-p-5e-06-mgi-20200608 PRSWEB_PHECODE172.2_20001-1060_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE172.2_20001-1060_P_5e-06_MGI_20200608 172.2 Cancer code, self-reported: non-melanoma skin cancer Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 18 0.38 0.000107167 0.139 0.494 0.483-0.506 OR 1.6 1.12-2.28 1.6 1.12-2.28 1.26 0.955-1.66 1.26 0.955-1.66 1.15 0.959-1.38 1.15 0.959-1.38 0.97 0.844-1.11 0.97 0.844-1.11 1.05 0.959-1.16 1.05 0.959-1.16 1.03 0.917-1.16 0.607 1.02 0.908-1.15 0.723 1.07 0.954-1.2 0.243 FALSE FALSE FALSE FALSE Both 2954 12944 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode172-2-c3-other-skin-p-5e-06-mgi-20200608 prsweb-phecode172-2-c3-other-skin-p-5e-06-mgi-20200608 PRSWEB_PHECODE172.2_C3-OTHER-SKIN_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE172.2_C3-OTHER-SKIN_P_5e-06_MGI_20200608 172.2 Other malignant neoplasms of skin Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 207 6.4e-50 0.0228129 0.137 0.588 0.576-0.601 OR 2.63 1.93-3.59 2.63 1.93-3.59 2.27 1.8-2.86 2.27 1.8-2.86 2.11 1.81-2.45 2.11 1.81-2.45 1.95 1.73-2.19 1.95 1.73-2.19 1.77 1.62-1.93 1.77 1.62-1.93 1.33 1.17-1.52 1.63e-05 1.53 1.35-1.74 1e-10 2.29 2.02-2.58 3.05e-40 TRUE FALSE FALSE FALSE Both 2954 12944 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode172-2-c44-p-5e-06-mgi-20200608 prsweb-phecode172-2-c44-p-5e-06-mgi-20200608 PRSWEB_PHECODE172.2_C44_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE172.2_C44_P_5e-06_MGI_20200608 172.2 Diagnoses - main ICD10: C44 Other malignant neoplasms of skin Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 131 5.9e-46 0.0206722 0.137 0.582 0.569-0.594 OR 2.38 1.73-3.26 2.38 1.73-3.26 2.48 1.98-3.11 2.48 1.98-3.11 2.06 1.77-2.41 2.06 1.77-2.41 1.84 1.64-2.07 1.84 1.64-2.07 1.69 1.55-1.85 1.69 1.55-1.85 1.22 1.07-1.39 0.00308 1.47 1.29-1.66 2.13e-09 2.09 1.85-2.35 3.79e-33 TRUE FALSE FALSE FALSE Both 2954 12944 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode172-2-ukbb-saige-hrc-x172-2-p-5e-06-mgi-20200608 prsweb-phecode172-2-ukbb-saige-hrc-x172-2-p-5e-06-mgi-20200608 PRSWEB_PHECODE172.2_UKBB-SAIGE-HRC-X172.2_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE172.2_UKBB-SAIGE-HRC-X172.2_P_5e-06_MGI_20200608 172.2 Other non-epithelial cancer of skin Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 160 1.2e-55 0.0259604 0.136 0.59 0.579-0.602 OR 2.87 2.12-3.89 2.87 2.12-3.89 2.54 2.03-3.19 2.54 2.03-3.19 2.2 1.89-2.56 2.2 1.89-2.56 1.98 1.77-2.23 1.98 1.77-2.23 1.79 1.64-1.95 1.79 1.64-1.95 1.39 1.22-1.59 6.84e-07 1.46 1.28-1.66 9.31e-09 2.3 2.04-2.6 1.65e-40 TRUE FALSE FALSE FALSE Both 2954 12944 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode172-2-c3-other-skin-p-5e-07-mgi-20200608 prsweb-phecode172-2-c3-other-skin-p-5e-07-mgi-20200608 PRSWEB_PHECODE172.2_C3-OTHER-SKIN_P_5e-07_MGI_20200608 P_5e-07 PRSWEB_PHECODE172.2_C3-OTHER-SKIN_P_5e-07_MGI_20200608 172.2 Other malignant neoplasms of skin Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-07) UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 139 7.1e-50 0.0215929 0.137 0.586 0.574-0.599 OR 2.78 2.05-3.77 2.78 2.05-3.77 2.38 1.9-2.99 2.38 1.9-2.99 2.16 1.86-2.52 2.16 1.86-2.52 1.86 1.65-2.09 1.86 1.65-2.09 1.74 1.59-1.9 1.74 1.59-1.9 1.19 1.04-1.36 0.00989 1.51 1.33-1.71 2.11e-10 2.16 1.91-2.43 1.02e-35 TRUE FALSE FALSE FALSE Both 2954 12944 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode172-2-c44-p-5e-07-mgi-20200608 prsweb-phecode172-2-c44-p-5e-07-mgi-20200608 PRSWEB_PHECODE172.2_C44_P_5e-07_MGI_20200608 P_5e-07 PRSWEB_PHECODE172.2_C44_P_5e-07_MGI_20200608 172.2 Diagnoses - main ICD10: C44 Other malignant neoplasms of skin Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-07) UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 89 3.5e-46 0.0200985 0.137 0.581 0.569-0.594 OR 2.37 1.72-3.28 2.37 1.72-3.28 2.49 1.99-3.12 2.49 1.99-3.12 2.01 1.72-2.35 2.01 1.72-2.35 1.87 1.67-2.11 1.87 1.67-2.11 1.71 1.56-1.87 1.71 1.56-1.87 1.17 1.02-1.33 0.0202 1.41 1.24-1.6 9.93e-08 2.04 1.81-2.31 1.27e-31 TRUE FALSE FALSE FALSE Both 2954 12944 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode172-2-ukbb-saige-hrc-x172-2-p-5e-07-mgi-20200608 prsweb-phecode172-2-ukbb-saige-hrc-x172-2-p-5e-07-mgi-20200608 PRSWEB_PHECODE172.2_UKBB-SAIGE-HRC-X172.2_P_5e-07_MGI_20200608 P_5e-07 PRSWEB_PHECODE172.2_UKBB-SAIGE-HRC-X172.2_P_5e-07_MGI_20200608 172.2 Other non-epithelial cancer of skin Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative Fixed threshold (5e-07) UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 109 6.9e-55 0.0235709 0.136 0.589 0.577-0.601 OR 2.75 2.02-3.75 2.75 2.02-3.75 2.52 2.01-3.16 2.52 2.01-3.16 2.28 1.96-2.65 2.28 1.96-2.65 1.96 1.75-2.2 1.96 1.75-2.2 1.77 1.62-1.93 1.77 1.62-1.93 1.38 1.21-1.57 2e-06 1.55 1.36-1.76 4.38e-11 2.32 2.05-2.63 6.89e-41 TRUE FALSE FALSE FALSE Both 2954 12944 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode172-2-c3-other-skin-p-5e-09-mgi-20200608 prsweb-phecode172-2-c3-other-skin-p-5e-09-mgi-20200608 PRSWEB_PHECODE172.2_C3-OTHER-SKIN_P_5e-09_MGI_20200608 P_5e-09 PRSWEB_PHECODE172.2_C3-OTHER-SKIN_P_5e-09_MGI_20200608 172.2 Other malignant neoplasms of skin Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-09) UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 85 2.2e-48 0.0205517 0.137 0.585 0.573-0.598 OR 2.82 2.07-3.83 2.82 2.07-3.83 2.33 1.84-2.93 2.33 1.84-2.93 2.06 1.77-2.41 2.06 1.77-2.41 1.83 1.62-2.06 1.83 1.62-2.06 1.73 1.58-1.89 1.73 1.58-1.89 1.21 1.06-1.38 0.00469 1.58 1.39-1.79 1.71e-12 2.2 1.95-2.48 4.7e-37 TRUE FALSE FALSE FALSE Both 2954 12944 GRCh37/hg19 P<=5e-09 2020-06-08 prsweb-phecode172-2-c44-p-5e-09-mgi-20200608 prsweb-phecode172-2-c44-p-5e-09-mgi-20200608 PRSWEB_PHECODE172.2_C44_P_5e-09_MGI_20200608 P_5e-09 PRSWEB_PHECODE172.2_C44_P_5e-09_MGI_20200608 172.2 Diagnoses - main ICD10: C44 Other malignant neoplasms of skin Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-09) UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 51 1.5e-42 0.0177433 0.137 0.574 0.562-0.587 OR 2.07 1.48-2.89 2.07 1.48-2.89 2.24 1.77-2.84 2.24 1.77-2.84 2.1 1.8-2.45 2.1 1.8-2.45 1.73 1.53-1.95 1.73 1.53-1.95 1.65 1.51-1.8 1.65 1.51-1.8 1.28 1.12-1.46 0.00025 1.56 1.37-1.77 8.9e-12 2.1 1.86-2.38 6.25e-33 TRUE FALSE FALSE FALSE Both 2954 12944 GRCh37/hg19 P<=5e-09 2020-06-08 prsweb-phecode172-2-ukbb-saige-hrc-x172-2-p-5e-09-mgi-20200608 prsweb-phecode172-2-ukbb-saige-hrc-x172-2-p-5e-09-mgi-20200608 PRSWEB_PHECODE172.2_UKBB-SAIGE-HRC-X172.2_P_5e-09_MGI_20200608 P_5e-09 PRSWEB_PHECODE172.2_UKBB-SAIGE-HRC-X172.2_P_5e-09_MGI_20200608 172.2 Other non-epithelial cancer of skin Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative Fixed threshold (5e-09) UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 61 7.2e-53 0.020426 0.137 0.584 0.572-0.596 OR 3.09 2.28-4.19 3.09 2.28-4.19 2.68 2.14-3.34 2.68 2.14-3.34 2.21 1.9-2.57 2.21 1.9-2.57 1.96 1.75-2.2 1.96 1.75-2.2 1.75 1.6-1.91 1.75 1.6-1.91 1.25 1.09-1.42 0.00112 1.54 1.36-1.75 2.63e-11 2.23 1.97-2.51 7.63e-38 TRUE FALSE FALSE FALSE Both 2954 12944 GRCh37/hg19 P<=5e-09 2020-06-08 prsweb-phecode172-2-c3-other-skin-p-5e-08-mgi-20200608 prsweb-phecode172-2-c3-other-skin-p-5e-08-mgi-20200608 PRSWEB_PHECODE172.2_C3-OTHER-SKIN_P_5e-08_MGI_20200608 P_5e-08 PRSWEB_PHECODE172.2_C3-OTHER-SKIN_P_5e-08_MGI_20200608 172.2 Other malignant neoplasms of skin Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative GWAS Hits UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 108 1e-47 0.0199202 0.137 0.584 0.572-0.598 OR 2.73 2.01-3.72 2.73 2.01-3.72 2.54 2.02-3.19 2.54 2.02-3.19 2.01 1.72-2.35 2.01 1.72-2.35 1.91 1.69-2.14 1.91 1.69-2.14 1.68 1.54-1.84 1.68 1.54-1.84 1.19 1.04-1.35 0.0105 1.51 1.33-1.71 1.48e-10 2.09 1.85-2.36 8e-33 TRUE FALSE FALSE TRUE Both 2954 12944 GRCh37/hg19 P<=5e-08 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000433/ScoringFiles/ phewas/PRSWEB_PHECODE172.2_C3-OTHER-SKIN_P_5e-08_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE172.2_C3-OTHER-SKIN_P_5e-08_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode172-2-c44-p-5e-08-mgi-20200608 prsweb-phecode172-2-c44-p-5e-08-mgi-20200608 PRSWEB_PHECODE172.2_C44_P_5e-08_MGI_20200608 P_5e-08 PRSWEB_PHECODE172.2_C44_P_5e-08_MGI_20200608 172.2 Diagnoses - main ICD10: C44 Other malignant neoplasms of skin Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative GWAS Hits UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 63 1.5e-45 0.0198259 0.137 0.579 0.566-0.592 OR 2.21 1.6-3.06 2.21 1.6-3.06 2.07 1.63-2.63 2.07 1.63-2.63 2.17 1.86-2.53 2.17 1.86-2.53 1.75 1.56-1.98 1.75 1.56-1.98 1.7 1.55-1.86 1.7 1.55-1.86 1.21 1.06-1.37 0.00544 1.49 1.32-1.69 4.8e-10 2.09 1.86-2.36 5.54e-33 TRUE FALSE FALSE TRUE Both 2954 12944 GRCh37/hg19 P<=5e-08 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000437/ScoringFiles/ phewas/PRSWEB_PHECODE172.2_C44_P_5e-08_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE172.2_C44_P_5e-08_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode172-2-ukbb-saige-hrc-x172-2-p-5e-08-mgi-20200608 prsweb-phecode172-2-ukbb-saige-hrc-x172-2-p-5e-08-mgi-20200608 PRSWEB_PHECODE172.2_UKBB-SAIGE-HRC-X172.2_P_5e-08_MGI_20200608 P_5e-08 PRSWEB_PHECODE172.2_UKBB-SAIGE-HRC-X172.2_P_5e-08_MGI_20200608 172.2 Other non-epithelial cancer of skin Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative GWAS Hits UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 77 2.2e-53 0.0202603 0.136 0.586 0.574-0.599 OR 2.65 1.94-3.62 2.65 1.94-3.62 2.74 2.2-3.42 2.74 2.2-3.42 2.15 1.85-2.51 2.15 1.85-2.51 1.98 1.76-2.22 1.98 1.76-2.22 1.78 1.63-1.94 1.78 1.63-1.94 1.21 1.06-1.39 0.00418 1.54 1.36-1.75 2.2e-11 2.24 1.98-2.53 2.51e-38 TRUE FALSE FALSE TRUE Both 2954 12944 GRCh37/hg19 P<=5e-08 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000441/ScoringFiles/ phewas/PRSWEB_PHECODE172.2_UKBB-SAIGE-HRC-X172.2_P_5e-08_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE172.2_UKBB-SAIGE-HRC-X172.2_P_5e-08_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode172-2-20001-1060-pt-mgi-20200608 prsweb-phecode172-2-20001-1060-pt-mgi-20200608 PRSWEB_PHECODE172.2_20001-1060_PT_MGI_20200608 P&T PRSWEB_PHECODE172.2_20001-1060_PT_MGI_20200608 172.2 Cancer code, self-reported: non-melanoma skin cancer Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative P&T UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 177 0.55 0.000765815 0.139 0.5 0.489-0.512 OR 1.12 0.756-1.65 1.12 0.756-1.65 1.05 0.786-1.4 1.05 0.786-1.4 0.979 0.807-1.19 0.979 0.807-1.19 0.928 0.805-1.07 0.928 0.805-1.07 1.05 0.951-1.15 1.05 0.951-1.15 1.11 0.986-1.25 0.0849 1.05 0.935-1.19 0.391 1.1 0.98-1.24 0.103 FALSE FALSE FALSE FALSE Both 2954 12944 GRCh37/hg19 P<=9.97e-05 2020-06-08 prsweb-phecode172-2-c3-other-skin-pt-mgi-20200608 prsweb-phecode172-2-c3-other-skin-pt-mgi-20200608 PRSWEB_PHECODE172.2_C3-OTHER-SKIN_PT_MGI_20200608 P&T PRSWEB_PHECODE172.2_C3-OTHER-SKIN_PT_MGI_20200608 172.2 Other malignant neoplasms of skin Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative P&T UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 446 1.6e-45 0.0246508 0.137 0.584 0.572-0.597 OR 2.7 1.99-3.66 2.7 1.99-3.66 2.31 1.84-2.89 2.31 1.84-2.89 2.02 1.73-2.36 2.02 1.73-2.36 1.9 1.69-2.14 1.9 1.69-2.14 1.73 1.58-1.89 1.73 1.58-1.89 1.2 1.05-1.37 0.00569 1.43 1.26-1.62 2.67e-08 2.1 1.86-2.37 1.79e-33 TRUE FALSE FALSE TRUE Both 2954 12944 GRCh37/hg19 P<=5e-05 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000435/ScoringFiles/ phewas/PRSWEB_PHECODE172.2_C3-OTHER-SKIN_PT_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE172.2_C3-OTHER-SKIN_PT_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode172-2-c44-pt-mgi-20200608 prsweb-phecode172-2-c44-pt-mgi-20200608 PRSWEB_PHECODE172.2_C44_PT_MGI_20200608 P&T PRSWEB_PHECODE172.2_C44_PT_MGI_20200608 172.2 Diagnoses - main ICD10: C44 Other malignant neoplasms of skin Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative P&T UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 467 1.3e-43 0.0239255 0.137 0.583 0.57-0.595 OR 2.17 1.57-3.01 2.17 1.57-3.01 1.98 1.56-2.51 1.98 1.56-2.51 1.93 1.65-2.26 1.93 1.65-2.26 1.85 1.65-2.09 1.85 1.65-2.09 1.69 1.55-1.85 1.69 1.55-1.85 1.31 1.15-1.49 6.54e-05 1.52 1.34-1.72 1.28e-10 2.17 1.92-2.45 1.43e-35 TRUE FALSE FALSE TRUE Both 2954 12944 GRCh37/hg19 P<=9.99e-05 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000439/ScoringFiles/ phewas/PRSWEB_PHECODE172.2_C44_PT_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE172.2_C44_PT_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode172-2-ukbb-saige-hrc-x172-2-pt-mgi-20200608 prsweb-phecode172-2-ukbb-saige-hrc-x172-2-pt-mgi-20200608 PRSWEB_PHECODE172.2_UKBB-SAIGE-HRC-X172.2_PT_MGI_20200608 P&T PRSWEB_PHECODE172.2_UKBB-SAIGE-HRC-X172.2_PT_MGI_20200608 172.2 Other non-epithelial cancer of skin Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative P&T UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 177 4.3e-57 0.0272869 0.136 0.591 0.579-0.603 OR 2.89 2.14-3.92 2.89 2.14-3.92 2.74 2.2-3.42 2.74 2.2-3.42 2.21 1.9-2.57 2.21 1.9-2.57 2.04 1.82-2.29 2.04 1.82-2.29 1.75 1.6-1.92 1.75 1.6-1.92 1.39 1.22-1.58 9.45e-07 1.52 1.33-1.73 2.65e-10 2.31 2.04-2.61 1.74e-40 TRUE FALSE FALSE TRUE Both 2954 12944 GRCh37/hg19 P<=7.94e-06 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000443/ScoringFiles/ phewas/PRSWEB_PHECODE172.2_UKBB-SAIGE-HRC-X172.2_PT_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE172.2_UKBB-SAIGE-HRC-X172.2_PT_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode172-2-20001-1060-prs-cs-mgi-20200608 prsweb-phecode172-2-20001-1060-prs-cs-mgi-20200608 PRSWEB_PHECODE172.2_20001-1060_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE172.2_20001-1060_PRS-CS_MGI_20200608 172.2 Cancer code, self-reported: non-melanoma skin cancer Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative PRS-CS UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1075656 0.081 0.00194814 0.139 0.509 0.497-0.522 OR 1.32 0.898-1.93 1.32 0.898-1.93 1.16 0.871-1.53 1.16 0.871-1.53 1.18 0.987-1.42 1.18 0.987-1.42 1.21 1.06-1.38 1.21 1.06-1.38 1.08 0.983-1.19 1.08 0.983-1.19 1.06 0.943-1.2 0.323 1.05 0.928-1.18 0.46 1.11 0.992-1.25 0.0683 FALSE FALSE FALSE FALSE Both 2954 12944 GRCh37/hg19 auto 2020-06-08 prsweb-phecode172-2-c3-other-skin-prs-cs-mgi-20200608 prsweb-phecode172-2-c3-other-skin-prs-cs-mgi-20200608 PRSWEB_PHECODE172.2_C3-OTHER-SKIN_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE172.2_C3-OTHER-SKIN_PRS-CS_MGI_20200608 172.2 Other malignant neoplasms of skin Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative PRS-CS UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1111490 1.1e-45 0.0281502 0.137 0.586 0.573-0.598 OR 1.99 1.43-2.78 1.99 1.43-2.78 1.87 1.46-2.38 1.87 1.46-2.38 1.79 1.52-2.1 1.79 1.52-2.1 1.77 1.57-1.99 1.77 1.57-1.99 1.81 1.66-1.98 1.81 1.66-1.98 1.38 1.21-1.57 1.28e-06 1.43 1.26-1.63 4.82e-08 2.33 2.06-2.64 7.38e-42 TRUE FALSE FALSE TRUE Both 2954 12944 GRCh37/hg19 auto https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000434/ScoringFiles/ phewas/PRSWEB_PHECODE172.2_C3-OTHER-SKIN_PRS-CS_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE172.2_C3-OTHER-SKIN_PRS-CS_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode172-2-c44-prs-cs-mgi-20200608 prsweb-phecode172-2-c44-prs-cs-mgi-20200608 PRSWEB_PHECODE172.2_C44_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE172.2_C44_PRS-CS_MGI_20200608 172.2 Diagnoses - main ICD10: C44 Other malignant neoplasms of skin Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative PRS-CS UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1111490 6.6e-36 0.0182478 0.137 0.575 0.562-0.587 OR 1.79 1.28-2.51 1.79 1.28-2.51 1.8 1.41-2.29 1.8 1.41-2.29 1.82 1.56-2.14 1.82 1.56-2.14 1.71 1.52-1.93 1.71 1.52-1.93 1.66 1.52-1.81 1.66 1.52-1.81 1.15 1.01-1.31 0.0346 1.4 1.23-1.59 1.63e-07 1.96 1.74-2.21 1.98e-28 TRUE FALSE FALSE TRUE Both 2954 12944 GRCh37/hg19 auto https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000438/ScoringFiles/ phewas/PRSWEB_PHECODE172.2_C44_PRS-CS_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE172.2_C44_PRS-CS_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode172-2-ukbb-saige-hrc-x172-2-prs-cs-mgi-20200608 prsweb-phecode172-2-ukbb-saige-hrc-x172-2-prs-cs-mgi-20200608 PRSWEB_PHECODE172.2_UKBB-SAIGE-HRC-X172.2_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE172.2_UKBB-SAIGE-HRC-X172.2_PRS-CS_MGI_20200608 172.2 Other non-epithelial cancer of skin Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative PRS-CS UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1119238 6.7e-45 0.022207 0.137 0.584 0.572-0.595 OR 2.35 1.71-3.22 2.35 1.71-3.22 2.32 1.84-2.92 2.32 1.84-2.92 1.98 1.7-2.32 1.98 1.7-2.32 1.79 1.59-2.02 1.79 1.59-2.02 1.7 1.56-1.86 1.7 1.56-1.86 1.33 1.17-1.52 1.75e-05 1.54 1.36-1.75 3.44e-11 2.19 1.94-2.48 3.53e-36 TRUE FALSE FALSE TRUE Both 2954 12944 GRCh37/hg19 auto https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000442/ScoringFiles/ phewas/PRSWEB_PHECODE172.2_UKBB-SAIGE-HRC-X172.2_PRS-CS_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE172.2_UKBB-SAIGE-HRC-X172.2_PRS-CS_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode172-2-20001-1060-lassosum-mgi-20200608 prsweb-phecode172-2-20001-1060-lassosum-mgi-20200608 PRSWEB_PHECODE172.2_20001-1060_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE172.2_20001-1060_LASSOSUM_MGI_20200608 172.2 Cancer code, self-reported: non-melanoma skin cancer Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative lassosum UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 4882215 0.17 0.00131817 0.139 0.509 0.497-0.521 OR 0.944 0.61-1.46 0.944 0.61-1.46 0.996 0.736-1.35 0.996 0.736-1.35 1.07 0.886-1.29 1.07 0.886-1.29 1.01 0.883-1.17 1.01 0.883-1.17 1.04 0.948-1.15 1.04 0.948-1.15 1.02 0.907-1.15 0.727 1.09 0.966-1.22 0.168 1.08 0.961-1.22 0.196 FALSE FALSE FALSE FALSE Both 2954 12944 GRCh37/hg19 s=1;Lambda=0.001 2020-06-08 prsweb-phecode172-2-c3-other-skin-lassosum-mgi-20200608 prsweb-phecode172-2-c3-other-skin-lassosum-mgi-20200608 PRSWEB_PHECODE172.2_C3-OTHER-SKIN_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE172.2_C3-OTHER-SKIN_LASSOSUM_MGI_20200608 172.2 Other malignant neoplasms of skin Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative lassosum UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 16626 3.2e-46 0.0257042 0.137 0.584 0.571-0.596 OR 2.22 1.61-3.06 2.22 1.61-3.06 2.15 1.7-2.71 2.15 1.7-2.71 2.08 1.78-2.43 2.08 1.78-2.43 1.98 1.76-2.23 1.98 1.76-2.23 1.71 1.56-1.87 1.71 1.56-1.87 1.19 1.05-1.36 0.00886 1.54 1.35-1.74 2.51e-11 2.11 1.87-2.38 7.04e-34 TRUE FALSE FALSE TRUE Both 2954 12944 GRCh37/hg19 s=0.2;Lambda=0.01129 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000436/ScoringFiles/ phewas/PRSWEB_PHECODE172.2_C3-OTHER-SKIN_LASSOSUM_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE172.2_C3-OTHER-SKIN_LASSOSUM_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode172-2-c44-lassosum-mgi-20200608 prsweb-phecode172-2-c44-lassosum-mgi-20200608 PRSWEB_PHECODE172.2_C44_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE172.2_C44_LASSOSUM_MGI_20200608 172.2 Diagnoses - main ICD10: C44 Other malignant neoplasms of skin Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative lassosum UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 2111 1.6e-44 0.0210061 0.137 0.581 0.569-0.592 OR 2.55 1.87-3.46 2.55 1.87-3.46 2.27 1.81-2.85 2.27 1.81-2.85 2.03 1.74-2.37 2.03 1.74-2.37 1.79 1.58-2.01 1.79 1.58-2.01 1.72 1.57-1.88 1.72 1.57-1.88 1.36 1.19-1.55 3.75e-06 1.49 1.31-1.69 1.01e-09 2.22 1.96-2.51 3.32e-37 TRUE FALSE FALSE TRUE Both 2954 12944 GRCh37/hg19 s=0.2;Lambda=0.01833 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000440/ScoringFiles/ phewas/PRSWEB_PHECODE172.2_C44_LASSOSUM_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE172.2_C44_LASSOSUM_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode172-2-ukbb-saige-hrc-x172-2-lassosum-mgi-20200608 prsweb-phecode172-2-ukbb-saige-hrc-x172-2-lassosum-mgi-20200608 PRSWEB_PHECODE172.2_UKBB-SAIGE-HRC-X172.2_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE172.2_UKBB-SAIGE-HRC-X172.2_LASSOSUM_MGI_20200608 172.2 Other non-epithelial cancer of skin Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative lassosum UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 7231 2.4e-54 0.0243516 0.136 0.59 0.578-0.601 OR 3.5 2.63-4.65 3.5 2.63-4.65 2.8 2.25-3.48 2.8 2.25-3.48 2.1 1.8-2.45 2.1 1.8-2.45 1.97 1.76-2.22 1.97 1.76-2.22 1.76 1.61-1.93 1.76 1.61-1.93 1.24 1.08-1.41 0.00158 1.56 1.37-1.77 8.1e-12 2.23 1.98-2.52 4.32e-38 TRUE FALSE FALSE TRUE Both 2954 12944 GRCh37/hg19 s=0.2;Lambda=0.01438 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000444/ScoringFiles/ phewas/PRSWEB_PHECODE172.2_UKBB-SAIGE-HRC-X172.2_LASSOSUM_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE172.2_UKBB-SAIGE-HRC-X172.2_LASSOSUM_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode172-21-20001-1061-p-5e-05-mgi-20200608 prsweb-phecode172-21-20001-1061-p-5e-05-mgi-20200608 PRSWEB_PHECODE172.21_20001-1061_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE172.21_20001-1061_P_5e-05_MGI_20200608 172.21 Cancer code, self-reported: basal cell carcinoma Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 192 4e-24 0.0159093 0.108 0.579 0.563-0.595 OR 1.91 1.25-2.92 1.91 1.25-2.92 1.91 1.4-2.61 1.91 1.4-2.61 1.79 1.45-2.2 1.79 1.45-2.2 1.72 1.47-2.02 1.72 1.47-2.02 1.64 1.46-1.85 1.64 1.46-1.85 1.26 1.06-1.5 0.00933 1.48 1.25-1.75 7.47e-06 2.04 1.73-2.39 5.25e-18 TRUE FALSE FALSE FALSE Both 1481 9841 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode172-21-20001-1073-p-5e-05-mgi-20200608 prsweb-phecode172-21-20001-1073-p-5e-05-mgi-20200608 PRSWEB_PHECODE172.21_20001-1073_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE172.21_20001-1073_P_5e-05_MGI_20200608 172.21 Cancer code, self-reported: rodent ulcer Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 96 0.38 0.000306881 0.109 0.5 0.484-0.516 OR 1.03 0.582-1.8 1.03 0.582-1.8 1.05 0.703-1.56 1.05 0.703-1.56 1.01 0.784-1.3 1.01 0.784-1.3 0.987 0.819-1.19 0.987 0.819-1.19 0.956 0.84-1.09 0.956 0.84-1.09 1.23 1.05-1.44 0.00996 1.12 0.955-1.31 0.163 1.06 0.903-1.25 0.472 FALSE FALSE FALSE FALSE Both 1481 9841 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode172-21-bcc-chahal-p-5e-05-mgi-20200608 prsweb-phecode172-21-bcc-chahal-p-5e-05-mgi-20200608 PRSWEB_PHECODE172.21_BCC-Chahal_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE172.21_BCC-Chahal_P_5e-05_MGI_20200608 172.21 Basal cell carcinoma Binary known and novel MGI Michigan Genomics Initiative Fixed threshold (5e-05) Chahal HS et al. 2018 27539887 https://www.ncbi.nlm.nih.gov/pubmed/?term=27539887 28 2.5e-67 0.0409264 0.106 0.632 0.616-0.647 OR 3.61 2.53-5.15 3.61 2.53-5.15 3.67 2.84-4.74 3.67 2.84-4.74 3.09 2.58-3.71 3.09 2.58-3.71 2.7 2.34-3.11 2.7 2.34-3.11 2.35 2.09-2.64 2.35 2.09-2.64 1.5 1.24-1.82 3.71e-05 1.87 1.55-2.25 4.74e-11 3.46 2.91-4.12 1.07e-44 TRUE FALSE FALSE FALSE Both 1481 9841 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode172-21-gwas-catalog-r2019-05-03-x172-21-p-5e-05-mgi-20200608 prsweb-phecode172-21-gwas-catalog-r2019-05-03-x172-21-p-5e-05-mgi-20200608 PRSWEB_PHECODE172.21_GWAS-Catalog-r2019-05-03-X172.21_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE172.21_GWAS-Catalog-r2019-05-03-X172.21_P_5e-05_MGI_20200608 172.21 Basal cell carcinoma Binary 39 unique SNPs MGI Michigan Genomics Initiative Fixed threshold (5e-05) GWAS Catalog (2019-05-03) 18849993;19151717;21700618;24403052;25855136;27539887;28177523 https://www.ncbi.nlm.nih.gov/pubmed/?term=18849993+19151717+21700618+24403052+25855136+27539887+28177523 32 1.3e-61 0.0432784 0.106 0.628 0.613-0.644 OR 3.65 2.57-5.18 3.65 2.57-5.18 3.42 2.63-4.44 3.42 2.63-4.44 2.77 2.3-3.33 2.77 2.3-3.33 2.46 2.13-2.85 2.46 2.13-2.85 2.26 2.01-2.53 2.26 2.01-2.53 1.48 1.22-1.79 7.51e-05 1.95 1.62-2.35 1.38e-12 3.34 2.81-3.98 3.85e-42 TRUE FALSE FALSE FALSE Both 1481 9841 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode172-21-20001-1061-p-5e-06-mgi-20200608 prsweb-phecode172-21-20001-1061-p-5e-06-mgi-20200608 PRSWEB_PHECODE172.21_20001-1061_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE172.21_20001-1061_P_5e-06_MGI_20200608 172.21 Cancer code, self-reported: basal cell carcinoma Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 55 2.2e-31 0.0241832 0.108 0.587 0.571-0.603 OR 3.05 2.1-4.42 3.05 2.1-4.42 2.74 2.08-3.6 2.74 2.08-3.6 2.15 1.77-2.62 2.15 1.77-2.62 1.98 1.7-2.3 1.98 1.7-2.3 1.81 1.61-2.03 1.81 1.61-2.03 1.36 1.14-1.63 0.000668 1.5 1.26-1.79 4.92e-06 2.31 1.96-2.72 1.1e-23 TRUE FALSE FALSE FALSE Both 1481 9841 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode172-21-20001-1073-p-5e-06-mgi-20200608 prsweb-phecode172-21-20001-1073-p-5e-06-mgi-20200608 PRSWEB_PHECODE172.21_20001-1073_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE172.21_20001-1073_P_5e-06_MGI_20200608 172.21 Cancer code, self-reported: rodent ulcer Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 12 0.022 0.00119655 0.109 0.504 0.488-0.52 OR 1.14 0.67-1.95 1.14 0.67-1.95 1.38 0.971-1.96 1.38 0.971-1.96 1.26 0.996-1.59 1.26 0.996-1.59 1.07 0.895-1.28 1.07 0.895-1.28 1.08 0.948-1.22 1.08 0.948-1.22 1.13 0.958-1.33 0.148 1.21 1.04-1.43 0.0167 1.2 1.02-1.4 0.0284 TRUE FALSE FALSE FALSE Both 1481 9841 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode172-21-bcc-chahal-p-5e-06-mgi-20200608 prsweb-phecode172-21-bcc-chahal-p-5e-06-mgi-20200608 PRSWEB_PHECODE172.21_BCC-Chahal_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE172.21_BCC-Chahal_P_5e-06_MGI_20200608 172.21 Basal cell carcinoma Binary known and novel MGI Michigan Genomics Initiative Fixed threshold (5e-06) Chahal HS et al. 2018 27539887 https://www.ncbi.nlm.nih.gov/pubmed/?term=27539887 28 2.5e-67 0.0409264 0.106 0.632 0.616-0.647 OR 3.61 2.53-5.15 3.61 2.53-5.15 3.67 2.84-4.74 3.67 2.84-4.74 3.09 2.58-3.71 3.09 2.58-3.71 2.7 2.34-3.11 2.7 2.34-3.11 2.35 2.09-2.64 2.35 2.09-2.64 1.5 1.24-1.82 3.71e-05 1.87 1.55-2.25 4.74e-11 3.46 2.91-4.12 1.07e-44 TRUE FALSE FALSE FALSE Both 1481 9841 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode172-21-gwas-catalog-r2019-05-03-x172-21-p-5e-06-mgi-20200608 prsweb-phecode172-21-gwas-catalog-r2019-05-03-x172-21-p-5e-06-mgi-20200608 PRSWEB_PHECODE172.21_GWAS-Catalog-r2019-05-03-X172.21_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE172.21_GWAS-Catalog-r2019-05-03-X172.21_P_5e-06_MGI_20200608 172.21 Basal cell carcinoma Binary 39 unique SNPs MGI Michigan Genomics Initiative Fixed threshold (5e-06) GWAS Catalog (2019-05-03) 18849993;19151717;21700618;24403052;25855136;27539887;28177523 https://www.ncbi.nlm.nih.gov/pubmed/?term=18849993+19151717+21700618+24403052+25855136+27539887+28177523 32 1.3e-61 0.0432784 0.106 0.628 0.613-0.644 OR 3.65 2.57-5.18 3.65 2.57-5.18 3.42 2.63-4.44 3.42 2.63-4.44 2.77 2.3-3.33 2.77 2.3-3.33 2.46 2.13-2.85 2.46 2.13-2.85 2.26 2.01-2.53 2.26 2.01-2.53 1.48 1.22-1.79 7.51e-05 1.95 1.62-2.35 1.38e-12 3.34 2.81-3.98 3.85e-42 TRUE FALSE FALSE FALSE Both 1481 9841 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode172-21-20001-1061-p-5e-07-mgi-20200608 prsweb-phecode172-21-20001-1061-p-5e-07-mgi-20200608 PRSWEB_PHECODE172.21_20001-1061_P_5e-07_MGI_20200608 P_5e-07 PRSWEB_PHECODE172.21_20001-1061_P_5e-07_MGI_20200608 172.21 Cancer code, self-reported: basal cell carcinoma Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-07) UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 30 2.4e-31 0.0236495 0.108 0.584 0.569-0.599 OR 2.16 1.42-3.28 2.16 1.42-3.28 2.25 1.68-3.03 2.25 1.68-3.03 2.41 2-2.92 2.41 2-2.92 2.15 1.86-2.5 2.15 1.86-2.5 1.73 1.54-1.95 1.73 1.54-1.95 1.45 1.22-1.74 4.1e-05 1.6 1.34-1.9 1.8e-07 2.33 1.97-2.75 2.25e-23 TRUE FALSE FALSE FALSE Both 1481 9841 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode172-21-bcc-chahal-p-5e-07-mgi-20200608 prsweb-phecode172-21-bcc-chahal-p-5e-07-mgi-20200608 PRSWEB_PHECODE172.21_BCC-Chahal_P_5e-07_MGI_20200608 P_5e-07 PRSWEB_PHECODE172.21_BCC-Chahal_P_5e-07_MGI_20200608 172.21 Basal cell carcinoma Binary known and novel MGI Michigan Genomics Initiative Fixed threshold (5e-07) Chahal HS et al. 2018 27539887 https://www.ncbi.nlm.nih.gov/pubmed/?term=27539887 28 2.5e-67 0.0409264 0.106 0.632 0.616-0.647 OR 3.61 2.53-5.15 3.61 2.53-5.15 3.67 2.84-4.74 3.67 2.84-4.74 3.09 2.58-3.71 3.09 2.58-3.71 2.7 2.34-3.11 2.7 2.34-3.11 2.35 2.09-2.64 2.35 2.09-2.64 1.5 1.24-1.82 3.71e-05 1.87 1.55-2.25 4.74e-11 3.46 2.91-4.12 1.07e-44 TRUE FALSE FALSE FALSE Both 1481 9841 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode172-21-gwas-catalog-r2019-05-03-x172-21-p-5e-07-mgi-20200608 prsweb-phecode172-21-gwas-catalog-r2019-05-03-x172-21-p-5e-07-mgi-20200608 PRSWEB_PHECODE172.21_GWAS-Catalog-r2019-05-03-X172.21_P_5e-07_MGI_20200608 P_5e-07 PRSWEB_PHECODE172.21_GWAS-Catalog-r2019-05-03-X172.21_P_5e-07_MGI_20200608 172.21 Basal cell carcinoma Binary 39 unique SNPs MGI Michigan Genomics Initiative Fixed threshold (5e-07) GWAS Catalog (2019-05-03) 18849993;19151717;21700618;24403052;25855136;27539887;28177523 https://www.ncbi.nlm.nih.gov/pubmed/?term=18849993+19151717+21700618+24403052+25855136+27539887+28177523 31 3.7e-62 0.0425876 0.106 0.629 0.614-0.646 OR 3.84 2.71-5.43 3.84 2.71-5.43 3.55 2.75-4.6 3.55 2.75-4.6 2.77 2.3-3.33 2.77 2.3-3.33 2.52 2.18-2.91 2.52 2.18-2.91 2.17 1.94-2.44 2.17 1.94-2.44 1.47 1.22-1.79 7.61e-05 2.01 1.68-2.42 9.03e-14 3.27 2.75-3.89 1.15e-40 TRUE FALSE FALSE FALSE Both 1481 9841 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode172-21-20001-1061-p-5e-09-mgi-20200608 prsweb-phecode172-21-20001-1061-p-5e-09-mgi-20200608 PRSWEB_PHECODE172.21_20001-1061_P_5e-09_MGI_20200608 P_5e-09 PRSWEB_PHECODE172.21_20001-1061_P_5e-09_MGI_20200608 172.21 Cancer code, self-reported: basal cell carcinoma Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-09) UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 14 6.4e-27 0.0174412 0.108 0.577 0.562-0.592 OR 2.9 1.99-4.24 2.9 1.99-4.24 2.49 1.87-3.31 2.49 1.87-3.31 2.25 1.85-2.74 2.25 1.85-2.74 1.95 1.67-2.27 1.95 1.67-2.27 1.66 1.48-1.87 1.66 1.48-1.87 1.32 1.11-1.57 0.00178 1.4 1.18-1.66 0.000139 2.06 1.76-2.43 2.24e-18 TRUE FALSE FALSE FALSE Both 1481 9841 GRCh37/hg19 P<=5e-09 2020-06-08 prsweb-phecode172-21-bcc-chahal-p-5e-09-mgi-20200608 prsweb-phecode172-21-bcc-chahal-p-5e-09-mgi-20200608 PRSWEB_PHECODE172.21_BCC-Chahal_P_5e-09_MGI_20200608 P_5e-09 PRSWEB_PHECODE172.21_BCC-Chahal_P_5e-09_MGI_20200608 172.21 Basal cell carcinoma Binary known and novel MGI Michigan Genomics Initiative Fixed threshold (5e-09) Chahal HS et al. 2018 27539887 https://www.ncbi.nlm.nih.gov/pubmed/?term=27539887 22 7.7e-67 0.0385653 0.106 0.631 0.615-0.646 OR 4.04 2.88-5.66 4.04 2.88-5.66 3.9 3.03-5.02 3.9 3.03-5.02 3.07 2.56-3.68 3.07 2.56-3.68 2.62 2.27-3.02 2.62 2.27-3.02 2.29 2.04-2.57 2.29 2.04-2.57 1.4 1.15-1.7 0.000667 1.94 1.61-2.33 1.72e-12 3.39 2.85-4.03 3.63e-43 TRUE FALSE FALSE FALSE Both 1481 9841 GRCh37/hg19 P<=5e-09 2020-06-08 prsweb-phecode172-21-gwas-catalog-r2019-05-03-x172-21-p-5e-09-mgi-20200608 prsweb-phecode172-21-gwas-catalog-r2019-05-03-x172-21-p-5e-09-mgi-20200608 PRSWEB_PHECODE172.21_GWAS-Catalog-r2019-05-03-X172.21_P_5e-09_MGI_20200608 P_5e-09 PRSWEB_PHECODE172.21_GWAS-Catalog-r2019-05-03-X172.21_P_5e-09_MGI_20200608 172.21 Basal cell carcinoma Binary 39 unique SNPs MGI Michigan Genomics Initiative Fixed threshold (5e-09) GWAS Catalog (2019-05-03) 18849993;19151717;21700618;24403052;25855136;27539887;28177523 https://www.ncbi.nlm.nih.gov/pubmed/?term=18849993+19151717+21700618+24403052+25855136+27539887+28177523 24 1.9e-62 0.043963 0.106 0.629 0.613-0.645 OR 4 2.82-5.68 4 2.82-5.68 3.29 2.53-4.29 3.29 2.53-4.29 2.82 2.35-3.38 2.82 2.35-3.38 2.64 2.29-3.05 2.64 2.29-3.05 2.23 1.99-2.5 2.23 1.99-2.5 1.48 1.22-1.79 6.23e-05 1.81 1.51-2.18 2.57e-10 3.23 2.72-3.84 1.69e-40 TRUE FALSE FALSE FALSE Both 1481 9841 GRCh37/hg19 P<=5e-09 2020-06-08 prsweb-phecode172-21-20001-1061-p-5e-08-mgi-20200608 prsweb-phecode172-21-20001-1061-p-5e-08-mgi-20200608 PRSWEB_PHECODE172.21_20001-1061_P_5e-08_MGI_20200608 P_5e-08 PRSWEB_PHECODE172.21_20001-1061_P_5e-08_MGI_20200608 172.21 Cancer code, self-reported: basal cell carcinoma Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative GWAS Hits UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 19 3e-25 0.0185456 0.108 0.571 0.555-0.587 OR 2.54 1.72-3.74 2.54 1.72-3.74 2.33 1.74-3.13 2.33 1.74-3.13 2.17 1.79-2.64 2.17 1.79-2.64 1.95 1.67-2.27 1.95 1.67-2.27 1.58 1.4-1.77 1.58 1.4-1.77 1.36 1.14-1.62 0.000656 1.58 1.33-1.87 1.87e-07 2.08 1.76-2.45 3.19e-18 TRUE FALSE FALSE TRUE Both 1481 9841 GRCh37/hg19 P<=5e-08 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000445/ScoringFiles/ phewas/PRSWEB_PHECODE172.21_20001-1061_P_5e-08_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE172.21_20001-1061_P_5e-08_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode172-21-bcc-chahal-p-5e-08-mgi-20200608 prsweb-phecode172-21-bcc-chahal-p-5e-08-mgi-20200608 PRSWEB_PHECODE172.21_BCC-Chahal_P_5e-08_MGI_20200608 P_5e-08 PRSWEB_PHECODE172.21_BCC-Chahal_P_5e-08_MGI_20200608 172.21 Basal cell carcinoma Binary known and novel MGI Michigan Genomics Initiative GWAS Hits Chahal HS et al. 2018 27539887 https://www.ncbi.nlm.nih.gov/pubmed/?term=27539887 28 2.5e-67 0.0409264 0.106 0.632 0.616-0.647 OR 3.61 2.53-5.15 3.61 2.53-5.15 3.67 2.84-4.74 3.67 2.84-4.74 3.09 2.58-3.71 3.09 2.58-3.71 2.7 2.34-3.11 2.7 2.34-3.11 2.35 2.09-2.64 2.35 2.09-2.64 1.5 1.24-1.82 3.71e-05 1.87 1.55-2.25 4.74e-11 3.46 2.91-4.12 1.07e-44 TRUE FALSE FALSE TRUE Both 1481 9841 GRCh37/hg19 P<=5e-08 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000452/ScoringFiles/ phewas/PRSWEB_PHECODE172.21_BCC-Chahal_P_5e-08_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE172.21_BCC-Chahal_P_5e-08_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode172-21-gwas-catalog-r2019-05-03-x172-21-p-5e-08-mgi-20200608 prsweb-phecode172-21-gwas-catalog-r2019-05-03-x172-21-p-5e-08-mgi-20200608 PRSWEB_PHECODE172.21_GWAS-Catalog-r2019-05-03-X172.21_P_5e-08_MGI_20200608 P_5e-08 PRSWEB_PHECODE172.21_GWAS-Catalog-r2019-05-03-X172.21_P_5e-08_MGI_20200608 172.21 Basal cell carcinoma Binary 39 unique SNPs MGI Michigan Genomics Initiative GWAS Hits GWAS Catalog (2019-05-03) 18849993;19151717;21700618;24403052;25855136;27539887;28177523 https://www.ncbi.nlm.nih.gov/pubmed/?term=18849993+19151717+21700618+24403052+25855136+27539887+28177523 30 7.7e-63 0.0420863 0.106 0.63 0.615-0.646 OR 3.95 2.79-5.58 3.95 2.79-5.58 3.27 2.51-4.26 3.27 2.51-4.26 2.77 2.3-3.33 2.77 2.3-3.33 2.48 2.15-2.87 2.48 2.15-2.87 2.21 1.97-2.48 2.21 1.97-2.48 1.56 1.28-1.89 6.77e-06 1.98 1.64-2.38 6e-13 3.35 2.81-3.99 6.89e-42 TRUE FALSE FALSE TRUE Both 1481 9841 GRCh37/hg19 P<=5e-08 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000456/ScoringFiles/ phewas/PRSWEB_PHECODE172.21_GWAS-Catalog-r2019-05-03-X172.21_P_5e-08_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE172.21_GWAS-Catalog-r2019-05-03-X172.21_P_5e-08_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode172-21-20001-1061-pt-mgi-20200608 prsweb-phecode172-21-20001-1061-pt-mgi-20200608 PRSWEB_PHECODE172.21_20001-1061_PT_MGI_20200608 P&T PRSWEB_PHECODE172.21_20001-1061_PT_MGI_20200608 172.21 Cancer code, self-reported: basal cell carcinoma Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative P&T UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 72 1.7e-32 0.0255888 0.108 0.591 0.575-0.607 OR 2.5 1.68-3.71 2.5 1.68-3.71 2.6 1.96-3.46 2.6 1.96-3.46 2.29 1.89-2.78 2.29 1.89-2.78 2.14 1.85-2.49 2.14 1.85-2.49 1.72 1.53-1.93 1.72 1.53-1.93 1.22 1.02-1.46 0.0333 1.6 1.35-1.9 5.81e-08 2.18 1.85-2.56 6.5e-21 TRUE FALSE FALSE TRUE Both 1481 9841 GRCh37/hg19 P<=1e-05 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000447/ScoringFiles/ phewas/PRSWEB_PHECODE172.21_20001-1061_PT_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE172.21_20001-1061_PT_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode172-21-20001-1073-pt-mgi-20200608 prsweb-phecode172-21-20001-1073-pt-mgi-20200608 PRSWEB_PHECODE172.21_20001-1073_PT_MGI_20200608 P&T PRSWEB_PHECODE172.21_20001-1073_PT_MGI_20200608 172.21 Cancer code, self-reported: rodent ulcer Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative P&T UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 8 0.0064 0.0014844 0.109 0.504 0.489-0.52 OR 1.42 0.882-2.3 1.42 0.882-2.3 1.35 0.949-1.91 1.35 0.949-1.91 1.19 0.937-1.5 1.19 0.937-1.5 1.07 0.894-1.28 1.07 0.894-1.28 1.1 0.972-1.25 1.1 0.972-1.25 1.11 0.945-1.31 0.2 1.27 1.08-1.49 0.00349 1.24 1.06-1.46 0.00794 TRUE FALSE FALSE TRUE Both 1481 9841 GRCh37/hg19 P<=3.16e-06 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000450/ScoringFiles/ phewas/PRSWEB_PHECODE172.21_20001-1073_PT_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE172.21_20001-1073_PT_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode172-21-bcc-chahal-pt-mgi-20200608 prsweb-phecode172-21-bcc-chahal-pt-mgi-20200608 PRSWEB_PHECODE172.21_BCC-Chahal_PT_MGI_20200608 P&T PRSWEB_PHECODE172.21_BCC-Chahal_PT_MGI_20200608 172.21 Basal cell carcinoma Binary known and novel MGI Michigan Genomics Initiative P&T Chahal HS et al. 2018 27539887 https://www.ncbi.nlm.nih.gov/pubmed/?term=27539887 27 3.1e-67 0.0414549 0.106 0.632 0.616-0.647 OR 3.79 2.68-5.35 3.79 2.68-5.35 3.69 2.86-4.76 3.69 2.86-4.76 2.93 2.44-3.51 2.93 2.44-3.51 2.65 2.29-3.06 2.65 2.29-3.06 2.38 2.13-2.67 2.38 2.13-2.67 1.33 1.09-1.61 0.00426 1.87 1.55-2.24 2.7e-11 3.39 2.85-4.02 3.94e-44 TRUE FALSE FALSE TRUE Both 1481 9841 GRCh37/hg19 P<=3.98e-08 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000454/ScoringFiles/ phewas/PRSWEB_PHECODE172.21_BCC-Chahal_PT_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE172.21_BCC-Chahal_PT_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode172-21-gwas-catalog-r2019-05-03-x172-21-pt-mgi-20200608 prsweb-phecode172-21-gwas-catalog-r2019-05-03-x172-21-pt-mgi-20200608 PRSWEB_PHECODE172.21_GWAS-Catalog-r2019-05-03-X172.21_PT_MGI_20200608 P&T PRSWEB_PHECODE172.21_GWAS-Catalog-r2019-05-03-X172.21_PT_MGI_20200608 172.21 Basal cell carcinoma Binary 39 unique SNPs MGI Michigan Genomics Initiative P&T GWAS Catalog (2019-05-03) 18849993;19151717;21700618;24403052;25855136;27539887;28177523 https://www.ncbi.nlm.nih.gov/pubmed/?term=18849993+19151717+21700618+24403052+25855136+27539887+28177523 23 5.4e-62 0.0440364 0.106 0.628 0.612-0.644 OR 4.03 2.86-5.69 4.03 2.86-5.69 3.46 2.67-4.49 3.46 2.67-4.49 3.14 2.63-3.76 3.14 2.63-3.76 2.73 2.37-3.14 2.73 2.37-3.14 2.2 1.96-2.47 2.2 1.96-2.47 1.23 1.01-1.49 0.0356 1.79 1.5-2.14 2.07e-10 3 2.53-3.55 6.69e-37 TRUE FALSE FALSE TRUE Both 1481 9841 GRCh37/hg19 P<=2.51e-10 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000458/ScoringFiles/ phewas/PRSWEB_PHECODE172.21_GWAS-Catalog-r2019-05-03-X172.21_PT_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE172.21_GWAS-Catalog-r2019-05-03-X172.21_PT_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode172-21-20001-1061-prs-cs-mgi-20200608 prsweb-phecode172-21-20001-1061-prs-cs-mgi-20200608 PRSWEB_PHECODE172.21_20001-1061_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE172.21_20001-1061_PRS-CS_MGI_20200608 172.21 Cancer code, self-reported: basal cell carcinoma Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative PRS-CS UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1111490 4.2e-19 0.0145762 0.109 0.575 0.559-0.591 OR 1.42 0.871-2.33 1.42 0.871-2.33 1.4 0.993-1.97 1.4 0.993-1.97 1.67 1.35-2.07 1.67 1.35-2.07 1.68 1.44-1.97 1.68 1.44-1.97 1.54 1.37-1.73 1.54 1.37-1.73 1.15 0.964-1.37 0.12 1.49 1.26-1.76 2.48e-06 1.87 1.59-2.2 2.36e-14 TRUE FALSE FALSE TRUE Both 1481 9841 GRCh37/hg19 auto https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000446/ScoringFiles/ phewas/PRSWEB_PHECODE172.21_20001-1061_PRS-CS_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE172.21_20001-1061_PRS-CS_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode172-21-20001-1073-prs-cs-mgi-20200608 prsweb-phecode172-21-20001-1073-prs-cs-mgi-20200608 PRSWEB_PHECODE172.21_20001-1073_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE172.21_20001-1073_PRS-CS_MGI_20200608 172.21 Cancer code, self-reported: rodent ulcer Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative PRS-CS UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1073162 0.0016 0.00030855 0.109 0.525 0.509-0.54 OR 1.65 1.04-2.61 1.65 1.04-2.61 1.28 0.901-1.83 1.28 0.901-1.83 1.21 0.954-1.53 1.21 0.954-1.53 1.21 1.02-1.45 1.21 1.02-1.45 1.25 1.11-1.42 1.25 1.11-1.42 1.01 0.864-1.19 0.862 1.01 0.86-1.19 0.893 1.26 1.08-1.47 0.00306 TRUE FALSE FALSE TRUE Both 1481 9841 GRCh37/hg19 auto https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000449/ScoringFiles/ phewas/PRSWEB_PHECODE172.21_20001-1073_PRS-CS_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE172.21_20001-1073_PRS-CS_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode172-21-20001-1061-lassosum-mgi-20200608 prsweb-phecode172-21-20001-1061-lassosum-mgi-20200608 PRSWEB_PHECODE172.21_20001-1061_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE172.21_20001-1061_LASSOSUM_MGI_20200608 172.21 Cancer code, self-reported: basal cell carcinoma Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative lassosum UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 183 2.7e-34 0.02018 0.108 0.587 0.57-0.604 OR 2.93 2.03-4.25 2.93 2.03-4.25 2.83 2.16-3.72 2.83 2.16-3.72 2.32 1.92-2.81 2.32 1.92-2.81 2.07 1.78-2.41 2.07 1.78-2.41 1.94 1.73-2.18 1.94 1.73-2.18 1.27 1.06-1.52 0.00819 1.36 1.14-1.62 0.000668 2.35 2-2.76 4.52e-25 TRUE FALSE FALSE TRUE Both 1481 9841 GRCh37/hg19 s=0.2;Lambda=0.03793 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000448/ScoringFiles/ phewas/PRSWEB_PHECODE172.21_20001-1061_LASSOSUM_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE172.21_20001-1061_LASSOSUM_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode172-21-20001-1073-lassosum-mgi-20200608 prsweb-phecode172-21-20001-1073-lassosum-mgi-20200608 PRSWEB_PHECODE172.21_20001-1073_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE172.21_20001-1073_LASSOSUM_MGI_20200608 172.21 Cancer code, self-reported: rodent ulcer Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative lassosum UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 2231 1.2e-06 0.00278837 0.109 0.521 0.506-0.536 OR 2.44 1.65-3.62 2.44 1.65-3.62 1.94 1.43-2.64 1.94 1.43-2.64 1.62 1.3-2 1.62 1.3-2 1.36 1.15-1.61 1.36 1.15-1.61 1.28 1.13-1.45 1.28 1.13-1.45 1.06 0.896-1.24 0.519 1.1 0.932-1.29 0.265 1.35 1.15-1.58 0.000167 TRUE FALSE FALSE TRUE Both 1481 9841 GRCh37/hg19 s=1;Lambda=0.07848 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000451/ScoringFiles/ phewas/PRSWEB_PHECODE172.21_20001-1073_LASSOSUM_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE172.21_20001-1073_LASSOSUM_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode172-21-bcc-chahal-p-5e-05-ukb-20200608 prsweb-phecode172-21-bcc-chahal-p-5e-05-ukb-20200608 PRSWEB_PHECODE172.21_BCC-Chahal_P_5e-05_UKB_20200608 P_5e-05 PRSWEB_PHECODE172.21_BCC-Chahal_P_5e-05_UKB_20200608 172.21 Basal cell carcinoma Binary known and novel UKB UK Biobank Fixed threshold (5e-05) Chahal HS et al. 2018 27539887 https://www.ncbi.nlm.nih.gov/pubmed/?term=27539887 28 2.1e-185 0.0288777 0.0813 0.611 0.604-0.619 OR 2.8 2.33-3.36 2.8 2.33-3.36 2.73 2.39-3.12 2.73 2.39-3.12 2.23 2.03-2.45 2.23 2.03-2.45 2.2 2.04-2.36 2.2 2.04-2.36 1.98 1.87-2.1 1.98 1.87-2.1 1.43 1.3-1.57 1.9e-13 1.89 1.73-2.07 5.61e-43 2.82 2.59-3.08 3.89e-122 TRUE FALSE FALSE FALSE Both 5450 54568 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode172-21-gwas-catalog-r2019-05-03-x172-21-p-5e-05-ukb-20200608 prsweb-phecode172-21-gwas-catalog-r2019-05-03-x172-21-p-5e-05-ukb-20200608 PRSWEB_PHECODE172.21_GWAS-Catalog-r2019-05-03-X172.21_P_5e-05_UKB_20200608 P_5e-05 PRSWEB_PHECODE172.21_GWAS-Catalog-r2019-05-03-X172.21_P_5e-05_UKB_20200608 172.21 Basal cell carcinoma Binary 39 unique SNPs UKB UK Biobank Fixed threshold (5e-05) GWAS Catalog (2019-05-03) 18849993;19151717;21700618;24403052;25855136;27539887;28177523 https://www.ncbi.nlm.nih.gov/pubmed/?term=18849993+19151717+21700618+24403052+25855136+27539887+28177523 32 5e-201 0.0294605 0.0812 0.618 0.611-0.626 OR 2.95 2.46-3.53 2.95 2.46-3.53 2.69 2.35-3.07 2.69 2.35-3.07 2.34 2.13-2.57 2.34 2.13-2.57 2.17 2.01-2.33 2.17 2.01-2.33 2.03 1.91-2.15 2.03 1.91-2.15 1.5 1.36-1.66 1.95e-16 2.05 1.87-2.24 4.81e-52 3.05 2.79-3.33 5.1e-136 TRUE FALSE FALSE FALSE Both 5450 54568 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode172-21-bcc-chahal-p-5e-06-ukb-20200608 prsweb-phecode172-21-bcc-chahal-p-5e-06-ukb-20200608 PRSWEB_PHECODE172.21_BCC-Chahal_P_5e-06_UKB_20200608 P_5e-06 PRSWEB_PHECODE172.21_BCC-Chahal_P_5e-06_UKB_20200608 172.21 Basal cell carcinoma Binary known and novel UKB UK Biobank Fixed threshold (5e-06) Chahal HS et al. 2018 27539887 https://www.ncbi.nlm.nih.gov/pubmed/?term=27539887 28 2.1e-185 0.0288777 0.0813 0.611 0.604-0.619 OR 2.8 2.33-3.36 2.8 2.33-3.36 2.73 2.39-3.12 2.73 2.39-3.12 2.23 2.03-2.45 2.23 2.03-2.45 2.2 2.04-2.36 2.2 2.04-2.36 1.98 1.87-2.1 1.98 1.87-2.1 1.43 1.3-1.57 1.9e-13 1.89 1.73-2.07 5.61e-43 2.82 2.59-3.08 3.89e-122 TRUE FALSE FALSE FALSE Both 5450 54568 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode172-21-gwas-catalog-r2019-05-03-x172-21-p-5e-06-ukb-20200608 prsweb-phecode172-21-gwas-catalog-r2019-05-03-x172-21-p-5e-06-ukb-20200608 PRSWEB_PHECODE172.21_GWAS-Catalog-r2019-05-03-X172.21_P_5e-06_UKB_20200608 P_5e-06 PRSWEB_PHECODE172.21_GWAS-Catalog-r2019-05-03-X172.21_P_5e-06_UKB_20200608 172.21 Basal cell carcinoma Binary 39 unique SNPs UKB UK Biobank Fixed threshold (5e-06) GWAS Catalog (2019-05-03) 18849993;19151717;21700618;24403052;25855136;27539887;28177523 https://www.ncbi.nlm.nih.gov/pubmed/?term=18849993+19151717+21700618+24403052+25855136+27539887+28177523 32 5e-201 0.0294605 0.0812 0.618 0.611-0.626 OR 2.95 2.46-3.53 2.95 2.46-3.53 2.69 2.35-3.07 2.69 2.35-3.07 2.34 2.13-2.57 2.34 2.13-2.57 2.17 2.01-2.33 2.17 2.01-2.33 2.03 1.91-2.15 2.03 1.91-2.15 1.5 1.36-1.66 1.95e-16 2.05 1.87-2.24 4.81e-52 3.05 2.79-3.33 5.1e-136 TRUE FALSE FALSE FALSE Both 5450 54568 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode172-21-bcc-chahal-p-5e-07-ukb-20200608 prsweb-phecode172-21-bcc-chahal-p-5e-07-ukb-20200608 PRSWEB_PHECODE172.21_BCC-Chahal_P_5e-07_UKB_20200608 P_5e-07 PRSWEB_PHECODE172.21_BCC-Chahal_P_5e-07_UKB_20200608 172.21 Basal cell carcinoma Binary known and novel UKB UK Biobank Fixed threshold (5e-07) Chahal HS et al. 2018 27539887 https://www.ncbi.nlm.nih.gov/pubmed/?term=27539887 28 2.1e-185 0.0288777 0.0813 0.611 0.604-0.619 OR 2.8 2.33-3.36 2.8 2.33-3.36 2.73 2.39-3.12 2.73 2.39-3.12 2.23 2.03-2.45 2.23 2.03-2.45 2.2 2.04-2.36 2.2 2.04-2.36 1.98 1.87-2.1 1.98 1.87-2.1 1.43 1.3-1.57 1.9e-13 1.89 1.73-2.07 5.61e-43 2.82 2.59-3.08 3.89e-122 TRUE FALSE FALSE FALSE Both 5450 54568 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode172-21-gwas-catalog-r2019-05-03-x172-21-p-5e-07-ukb-20200608 prsweb-phecode172-21-gwas-catalog-r2019-05-03-x172-21-p-5e-07-ukb-20200608 PRSWEB_PHECODE172.21_GWAS-Catalog-r2019-05-03-X172.21_P_5e-07_UKB_20200608 P_5e-07 PRSWEB_PHECODE172.21_GWAS-Catalog-r2019-05-03-X172.21_P_5e-07_UKB_20200608 172.21 Basal cell carcinoma Binary 39 unique SNPs UKB UK Biobank Fixed threshold (5e-07) GWAS Catalog (2019-05-03) 18849993;19151717;21700618;24403052;25855136;27539887;28177523 https://www.ncbi.nlm.nih.gov/pubmed/?term=18849993+19151717+21700618+24403052+25855136+27539887+28177523 31 1.2e-196 0.0290503 0.0812 0.617 0.61-0.625 OR 3.03 2.53-3.62 3.03 2.53-3.62 2.76 2.42-3.15 2.76 2.42-3.15 2.33 2.12-2.56 2.33 2.12-2.56 2.19 2.03-2.35 2.19 2.03-2.35 2.03 1.92-2.16 2.03 1.92-2.16 1.5 1.36-1.65 2.84e-16 1.97 1.79-2.16 7.57e-47 3 2.75-3.28 6.45e-134 TRUE FALSE FALSE FALSE Both 5450 54568 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode172-21-bcc-chahal-p-5e-09-ukb-20200608 prsweb-phecode172-21-bcc-chahal-p-5e-09-ukb-20200608 PRSWEB_PHECODE172.21_BCC-Chahal_P_5e-09_UKB_20200608 P_5e-09 PRSWEB_PHECODE172.21_BCC-Chahal_P_5e-09_UKB_20200608 172.21 Basal cell carcinoma Binary known and novel UKB UK Biobank Fixed threshold (5e-09) Chahal HS et al. 2018 27539887 https://www.ncbi.nlm.nih.gov/pubmed/?term=27539887 22 1.2e-165 0.0272616 0.0815 0.604 0.597-0.612 OR 2.68 2.23-3.23 2.68 2.23-3.23 2.5 2.18-2.87 2.5 2.18-2.87 2.17 1.97-2.39 2.17 1.97-2.39 2.05 1.9-2.2 2.05 1.9-2.2 1.91 1.8-2.03 1.91 1.8-2.03 1.42 1.29-1.56 2.7e-13 1.84 1.68-2.01 6.24e-40 2.68 2.46-2.93 5.57e-112 TRUE FALSE FALSE FALSE Both 5450 54568 GRCh37/hg19 P<=5e-09 2020-06-08 prsweb-phecode172-21-gwas-catalog-r2019-05-03-x172-21-p-5e-09-ukb-20200608 prsweb-phecode172-21-gwas-catalog-r2019-05-03-x172-21-p-5e-09-ukb-20200608 PRSWEB_PHECODE172.21_GWAS-Catalog-r2019-05-03-X172.21_P_5e-09_UKB_20200608 P_5e-09 PRSWEB_PHECODE172.21_GWAS-Catalog-r2019-05-03-X172.21_P_5e-09_UKB_20200608 172.21 Basal cell carcinoma Binary 39 unique SNPs UKB UK Biobank Fixed threshold (5e-09) GWAS Catalog (2019-05-03) 18849993;19151717;21700618;24403052;25855136;27539887;28177523 https://www.ncbi.nlm.nih.gov/pubmed/?term=18849993+19151717+21700618+24403052+25855136+27539887+28177523 24 2.3e-191 0.0299216 0.0813 0.615 0.608-0.623 OR 3.05 2.55-3.64 3.05 2.55-3.64 2.73 2.39-3.12 2.73 2.39-3.12 2.34 2.13-2.57 2.34 2.13-2.57 2.2 2.04-2.36 2.2 2.04-2.36 2.01 1.89-2.13 2.01 1.89-2.13 1.5 1.36-1.65 1.52e-16 1.98 1.8-2.17 1.26e-47 2.97 2.72-3.24 5.54e-131 TRUE FALSE FALSE FALSE Both 5450 54568 GRCh37/hg19 P<=5e-09 2020-06-08 prsweb-phecode172-21-bcc-chahal-p-5e-08-ukb-20200608 prsweb-phecode172-21-bcc-chahal-p-5e-08-ukb-20200608 PRSWEB_PHECODE172.21_BCC-Chahal_P_5e-08_UKB_20200608 P_5e-08 PRSWEB_PHECODE172.21_BCC-Chahal_P_5e-08_UKB_20200608 172.21 Basal cell carcinoma Binary known and novel UKB UK Biobank GWAS Hits Chahal HS et al. 2018 27539887 https://www.ncbi.nlm.nih.gov/pubmed/?term=27539887 28 2.1e-185 0.0288777 0.0813 0.611 0.604-0.619 OR 2.8 2.33-3.36 2.8 2.33-3.36 2.73 2.39-3.12 2.73 2.39-3.12 2.23 2.03-2.45 2.23 2.03-2.45 2.2 2.04-2.36 2.2 2.04-2.36 1.98 1.87-2.1 1.98 1.87-2.1 1.43 1.3-1.57 1.9e-13 1.89 1.73-2.07 5.61e-43 2.82 2.59-3.08 3.89e-122 TRUE FALSE FALSE TRUE Both 5450 54568 GRCh37/hg19 P<=5e-08 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000453/ScoringFiles/ phewas/PRSWEB_PHECODE172.21_BCC-Chahal_P_5e-08_UKB_20200608/all.tsv phewas/PRSWEB_PHECODE172.21_BCC-Chahal_P_5e-08_UKB_20200608/exclusion.tsv 2020-06-08 prsweb-phecode172-21-gwas-catalog-r2019-05-03-x172-21-p-5e-08-ukb-20200608 prsweb-phecode172-21-gwas-catalog-r2019-05-03-x172-21-p-5e-08-ukb-20200608 PRSWEB_PHECODE172.21_GWAS-Catalog-r2019-05-03-X172.21_P_5e-08_UKB_20200608 P_5e-08 PRSWEB_PHECODE172.21_GWAS-Catalog-r2019-05-03-X172.21_P_5e-08_UKB_20200608 172.21 Basal cell carcinoma Binary 39 unique SNPs UKB UK Biobank GWAS Hits GWAS Catalog (2019-05-03) 18849993;19151717;21700618;24403052;25855136;27539887;28177523 https://www.ncbi.nlm.nih.gov/pubmed/?term=18849993+19151717+21700618+24403052+25855136+27539887+28177523 30 8.6e-196 0.0286856 0.0813 0.617 0.609-0.625 OR 3.11 2.6-3.71 3.11 2.6-3.71 2.62 2.28-3 2.62 2.28-3 2.32 2.11-2.54 2.32 2.11-2.54 2.17 2.01-2.33 2.17 2.01-2.33 2 1.89-2.12 2 1.89-2.12 1.52 1.38-1.67 2.18e-17 2.02 1.84-2.22 1.43e-50 3.02 2.76-3.3 1.1e-133 TRUE FALSE FALSE TRUE Both 5450 54568 GRCh37/hg19 P<=5e-08 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000457/ScoringFiles/ phewas/PRSWEB_PHECODE172.21_GWAS-Catalog-r2019-05-03-X172.21_P_5e-08_UKB_20200608/all.tsv phewas/PRSWEB_PHECODE172.21_GWAS-Catalog-r2019-05-03-X172.21_P_5e-08_UKB_20200608/exclusion.tsv 2020-06-08 prsweb-phecode172-21-bcc-chahal-pt-ukb-20200608 prsweb-phecode172-21-bcc-chahal-pt-ukb-20200608 PRSWEB_PHECODE172.21_BCC-Chahal_PT_UKB_20200608 P&T PRSWEB_PHECODE172.21_BCC-Chahal_PT_UKB_20200608 172.21 Basal cell carcinoma Binary known and novel UKB UK Biobank P&T Chahal HS et al. 2018 27539887 https://www.ncbi.nlm.nih.gov/pubmed/?term=27539887 28 2.1e-185 0.0288777 0.0813 0.611 0.604-0.619 OR 2.8 2.33-3.36 2.8 2.33-3.36 2.73 2.39-3.12 2.73 2.39-3.12 2.23 2.03-2.45 2.23 2.03-2.45 2.2 2.04-2.36 2.2 2.04-2.36 1.98 1.87-2.1 1.98 1.87-2.1 1.43 1.3-1.57 1.9e-13 1.89 1.73-2.07 5.61e-43 2.82 2.59-3.08 3.89e-122 TRUE FALSE FALSE TRUE Both 5450 54568 GRCh37/hg19 P<=4.2e-08 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000455/ScoringFiles/ phewas/PRSWEB_PHECODE172.21_BCC-Chahal_PT_UKB_20200608/all.tsv phewas/PRSWEB_PHECODE172.21_BCC-Chahal_PT_UKB_20200608/exclusion.tsv 2020-06-08 prsweb-phecode172-21-gwas-catalog-r2019-05-03-x172-21-pt-ukb-20200608 prsweb-phecode172-21-gwas-catalog-r2019-05-03-x172-21-pt-ukb-20200608 PRSWEB_PHECODE172.21_GWAS-Catalog-r2019-05-03-X172.21_PT_UKB_20200608 P&T PRSWEB_PHECODE172.21_GWAS-Catalog-r2019-05-03-X172.21_PT_UKB_20200608 172.21 Basal cell carcinoma Binary 39 unique SNPs UKB UK Biobank P&T GWAS Catalog (2019-05-03) 18849993;19151717;21700618;24403052;25855136;27539887;28177523 https://www.ncbi.nlm.nih.gov/pubmed/?term=18849993+19151717+21700618+24403052+25855136+27539887+28177523 24 2.3e-191 0.0299216 0.0813 0.615 0.608-0.623 OR 3.05 2.55-3.64 3.05 2.55-3.64 2.73 2.39-3.12 2.73 2.39-3.12 2.34 2.13-2.57 2.34 2.13-2.57 2.2 2.04-2.36 2.2 2.04-2.36 2.01 1.89-2.13 2.01 1.89-2.13 1.5 1.36-1.65 1.52e-16 1.98 1.8-2.17 1.26e-47 2.97 2.72-3.24 5.54e-131 TRUE FALSE FALSE TRUE Both 5450 54568 GRCh37/hg19 P<=5e-09 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000459/ScoringFiles/ phewas/PRSWEB_PHECODE172.21_GWAS-Catalog-r2019-05-03-X172.21_PT_UKB_20200608/all.tsv phewas/PRSWEB_PHECODE172.21_GWAS-Catalog-r2019-05-03-X172.21_PT_UKB_20200608/exclusion.tsv 2020-06-08 prsweb-phecode172-22-gwas-catalog-r2019-05-03-x172-22-p-5e-05-mgi-20200608 prsweb-phecode172-22-gwas-catalog-r2019-05-03-x172-22-p-5e-05-mgi-20200608 PRSWEB_PHECODE172.22_GWAS-Catalog-r2019-05-03-X172.22_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE172.22_GWAS-Catalog-r2019-05-03-X172.22_P_5e-05_MGI_20200608 172.22 Squamous cell carcinoma;Cutaneous squamous cell carcinoma Binary 19 unique SNPs MGI Michigan Genomics Initiative Fixed threshold (5e-05) GWAS Catalog (2019-05-03) 26829030;26908436;27424798 https://www.ncbi.nlm.nih.gov/pubmed/?term=26829030+26908436+27424798 18 8.6e-21 0.0178049 0.0983 0.581 0.56-0.599 OR 2.33 1.44-3.77 2.33 1.44-3.77 2.88 2.08-4 2.88 2.08-4 2.21 1.74-2.81 2.21 1.74-2.81 2 1.66-2.4 2 1.66-2.4 1.68 1.46-1.94 1.68 1.46-1.94 1.61 1.3-1.99 1.12e-05 1.59 1.28-1.96 2.41e-05 2.36 1.93-2.89 8.58e-17 TRUE FALSE FALSE FALSE Both 982 7491 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode172-22-cscc-chahal-p-5e-05-mgi-20200608 prsweb-phecode172-22-cscc-chahal-p-5e-05-mgi-20200608 PRSWEB_PHECODE172.22_cSCC-Chahal_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE172.22_cSCC-Chahal_P_5e-05_MGI_20200608 172.22 Squamous cell carcinoma Binary known and novel MGI Michigan Genomics Initiative Fixed threshold (5e-05) Chahal HS et al. 2018 27424798 https://www.ncbi.nlm.nih.gov/pubmed/?term=27424798 10 4e-30 0.0295004 0.0976 0.589 0.57-0.61 OR 4.54 3.07-6.71 4.54 3.07-6.71 3 2.17-4.14 3 2.17-4.14 2.48 1.98-3.12 2.48 1.98-3.12 2.13 1.78-2.55 2.13 1.78-2.55 1.87 1.62-2.15 1.87 1.62-2.15 1.26 1.01-1.57 0.0386 1.58 1.28-1.94 2.12e-05 2.42 1.98-2.95 4.09e-18 TRUE FALSE FALSE FALSE Both 982 7491 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode172-22-20001-1062-p-5e-06-mgi-20200608 prsweb-phecode172-22-20001-1062-p-5e-06-mgi-20200608 PRSWEB_PHECODE172.22_20001-1062_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE172.22_20001-1062_P_5e-06_MGI_20200608 172.22 Cancer code, self-reported: squamous cell carcinoma Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 19 0.9 0.000135558 0.0998 0.49 0.471-0.508 OR 1.22 0.66-2.25 1.22 0.66-2.25 1.08 0.681-1.72 1.08 0.681-1.72 1.17 0.877-1.56 1.17 0.877-1.56 1.08 0.866-1.34 1.08 0.866-1.34 0.989 0.847-1.16 0.989 0.847-1.16 0.897 0.743-1.08 0.261 0.936 0.775-1.13 0.491 0.929 0.77-1.12 0.439 FALSE FALSE FALSE FALSE Both 982 7491 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode172-22-gwas-catalog-r2019-05-03-x172-22-p-5e-06-mgi-20200608 prsweb-phecode172-22-gwas-catalog-r2019-05-03-x172-22-p-5e-06-mgi-20200608 PRSWEB_PHECODE172.22_GWAS-Catalog-r2019-05-03-X172.22_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE172.22_GWAS-Catalog-r2019-05-03-X172.22_P_5e-06_MGI_20200608 172.22 Squamous cell carcinoma;Cutaneous squamous cell carcinoma Binary 19 unique SNPs MGI Michigan Genomics Initiative Fixed threshold (5e-06) GWAS Catalog (2019-05-03) 26829030;26908436;27424798 https://www.ncbi.nlm.nih.gov/pubmed/?term=26829030+26908436+27424798 17 4.7e-22 0.02034 0.0982 0.584 0.565-0.601 OR 2.24 1.35-3.71 2.24 1.35-3.71 2.48 1.76-3.5 2.48 1.76-3.5 2.23 1.76-2.83 2.23 1.76-2.83 2.03 1.7-2.44 2.03 1.7-2.44 1.65 1.43-1.91 1.65 1.43-1.91 1.23 0.994-1.53 0.0569 1.64 1.34-2.02 1.96e-06 2.13 1.75-2.59 6.33e-14 TRUE FALSE FALSE FALSE Both 982 7491 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode172-22-cscc-chahal-p-5e-06-mgi-20200608 prsweb-phecode172-22-cscc-chahal-p-5e-06-mgi-20200608 PRSWEB_PHECODE172.22_cSCC-Chahal_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE172.22_cSCC-Chahal_P_5e-06_MGI_20200608 172.22 Squamous cell carcinoma Binary known and novel MGI Michigan Genomics Initiative Fixed threshold (5e-06) Chahal HS et al. 2018 27424798 https://www.ncbi.nlm.nih.gov/pubmed/?term=27424798 10 4e-30 0.0295004 0.0976 0.589 0.57-0.61 OR 4.54 3.07-6.71 4.54 3.07-6.71 3 2.17-4.14 3 2.17-4.14 2.48 1.98-3.12 2.48 1.98-3.12 2.13 1.78-2.55 2.13 1.78-2.55 1.87 1.62-2.15 1.87 1.62-2.15 1.26 1.01-1.57 0.0386 1.58 1.28-1.94 2.12e-05 2.42 1.98-2.95 4.09e-18 TRUE FALSE FALSE FALSE Both 982 7491 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode172-22-gwas-catalog-r2019-05-03-x172-22-p-5e-07-mgi-20200608 prsweb-phecode172-22-gwas-catalog-r2019-05-03-x172-22-p-5e-07-mgi-20200608 PRSWEB_PHECODE172.22_GWAS-Catalog-r2019-05-03-X172.22_P_5e-07_MGI_20200608 P_5e-07 PRSWEB_PHECODE172.22_GWAS-Catalog-r2019-05-03-X172.22_P_5e-07_MGI_20200608 172.22 Squamous cell carcinoma;Cutaneous squamous cell carcinoma Binary 19 unique SNPs MGI Michigan Genomics Initiative Fixed threshold (5e-07) GWAS Catalog (2019-05-03) 26829030;26908436;27424798 https://www.ncbi.nlm.nih.gov/pubmed/?term=26829030+26908436+27424798 14 6.4e-31 0.0290945 0.0975 0.597 0.578-0.616 OR 3.57 2.33-5.47 3.57 2.33-5.47 3.31 2.42-4.52 3.31 2.42-4.52 2.7 2.16-3.37 2.7 2.16-3.37 2.23 1.86-2.66 2.23 1.86-2.66 1.93 1.68-2.23 1.93 1.68-2.23 1.43 1.15-1.78 0.00128 1.62 1.31-2.01 9.72e-06 2.63 2.15-3.22 5.29e-21 TRUE FALSE FALSE FALSE Both 982 7491 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode172-22-cscc-chahal-p-5e-07-mgi-20200608 prsweb-phecode172-22-cscc-chahal-p-5e-07-mgi-20200608 PRSWEB_PHECODE172.22_cSCC-Chahal_P_5e-07_MGI_20200608 P_5e-07 PRSWEB_PHECODE172.22_cSCC-Chahal_P_5e-07_MGI_20200608 172.22 Squamous cell carcinoma Binary known and novel MGI Michigan Genomics Initiative Fixed threshold (5e-07) Chahal HS et al. 2018 27424798 https://www.ncbi.nlm.nih.gov/pubmed/?term=27424798 10 4e-30 0.0295004 0.0976 0.589 0.57-0.61 OR 4.54 3.07-6.71 4.54 3.07-6.71 3 2.17-4.14 3 2.17-4.14 2.48 1.98-3.12 2.48 1.98-3.12 2.13 1.78-2.55 2.13 1.78-2.55 1.87 1.62-2.15 1.87 1.62-2.15 1.26 1.01-1.57 0.0386 1.58 1.28-1.94 2.12e-05 2.42 1.98-2.95 4.09e-18 TRUE FALSE FALSE FALSE Both 982 7491 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode172-22-gwas-catalog-r2019-05-03-x172-22-p-5e-09-mgi-20200608 prsweb-phecode172-22-gwas-catalog-r2019-05-03-x172-22-p-5e-09-mgi-20200608 PRSWEB_PHECODE172.22_GWAS-Catalog-r2019-05-03-X172.22_P_5e-09_MGI_20200608 P_5e-09 PRSWEB_PHECODE172.22_GWAS-Catalog-r2019-05-03-X172.22_P_5e-09_MGI_20200608 172.22 Squamous cell carcinoma;Cutaneous squamous cell carcinoma Binary 19 unique SNPs MGI Michigan Genomics Initiative Fixed threshold (5e-09) GWAS Catalog (2019-05-03) 26829030;26908436;27424798 https://www.ncbi.nlm.nih.gov/pubmed/?term=26829030+26908436+27424798 7 2.3e-28 0.0297042 0.0977 0.593 0.573-0.613 OR 3.74 2.46-5.68 3.74 2.46-5.68 2.87 2.07-3.97 2.87 2.07-3.97 2.45 1.95-3.08 2.45 1.95-3.08 2.28 1.91-2.72 2.28 1.91-2.72 1.95 1.69-2.24 1.95 1.69-2.24 1.45 1.17-1.8 0.000805 1.52 1.23-1.88 0.000138 2.57 2.11-3.14 2.31e-20 TRUE FALSE FALSE FALSE Both 982 7491 GRCh37/hg19 P<=5e-09 2020-06-08 prsweb-phecode172-22-cscc-chahal-p-5e-09-mgi-20200608 prsweb-phecode172-22-cscc-chahal-p-5e-09-mgi-20200608 PRSWEB_PHECODE172.22_cSCC-Chahal_P_5e-09_MGI_20200608 P_5e-09 PRSWEB_PHECODE172.22_cSCC-Chahal_P_5e-09_MGI_20200608 172.22 Squamous cell carcinoma Binary known and novel MGI Michigan Genomics Initiative Fixed threshold (5e-09) Chahal HS et al. 2018 27424798 https://www.ncbi.nlm.nih.gov/pubmed/?term=27424798 5 2.4e-27 0.031315 0.0979 0.583 0.563-0.603 OR 3.65 2.41-5.53 3.65 2.41-5.53 3.11 2.26-4.28 3.11 2.26-4.28 2.35 1.86-2.96 2.35 1.86-2.96 2.11 1.76-2.53 2.11 1.76-2.53 1.9 1.65-2.19 1.9 1.65-2.19 1.05 0.843-1.31 0.655 1.55 1.26-1.9 3.36e-05 2.29 1.88-2.78 1.29e-16 TRUE FALSE FALSE FALSE Both 982 7491 GRCh37/hg19 P<=5e-09 2020-06-08 prsweb-phecode172-22-gwas-catalog-r2019-05-03-x172-22-p-5e-08-mgi-20200608 prsweb-phecode172-22-gwas-catalog-r2019-05-03-x172-22-p-5e-08-mgi-20200608 PRSWEB_PHECODE172.22_GWAS-Catalog-r2019-05-03-X172.22_P_5e-08_MGI_20200608 P_5e-08 PRSWEB_PHECODE172.22_GWAS-Catalog-r2019-05-03-X172.22_P_5e-08_MGI_20200608 172.22 Squamous cell carcinoma;Cutaneous squamous cell carcinoma Binary 19 unique SNPs MGI Michigan Genomics Initiative GWAS Hits GWAS Catalog (2019-05-03) 26829030;26908436;27424798 https://www.ncbi.nlm.nih.gov/pubmed/?term=26829030+26908436+27424798 13 3.7e-32 0.0285817 0.0974 0.599 0.579-0.618 OR 3.51 2.29-5.39 3.51 2.29-5.39 3.41 2.5-4.64 3.41 2.5-4.64 2.61 2.08-3.26 2.61 2.08-3.26 2.26 1.89-2.7 2.26 1.89-2.7 1.87 1.63-2.16 1.87 1.63-2.16 1.45 1.17-1.81 0.000892 1.74 1.41-2.16 3.67e-07 2.66 2.17-3.26 6.19e-21 TRUE FALSE FALSE TRUE Both 982 7491 GRCh37/hg19 P<=5e-08 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000461/ScoringFiles/ phewas/PRSWEB_PHECODE172.22_GWAS-Catalog-r2019-05-03-X172.22_P_5e-08_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE172.22_GWAS-Catalog-r2019-05-03-X172.22_P_5e-08_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode172-22-cscc-chahal-p-5e-08-mgi-20200608 prsweb-phecode172-22-cscc-chahal-p-5e-08-mgi-20200608 PRSWEB_PHECODE172.22_cSCC-Chahal_P_5e-08_MGI_20200608 P_5e-08 PRSWEB_PHECODE172.22_cSCC-Chahal_P_5e-08_MGI_20200608 172.22 Squamous cell carcinoma Binary known and novel MGI Michigan Genomics Initiative GWAS Hits Chahal HS et al. 2018 27424798 https://www.ncbi.nlm.nih.gov/pubmed/?term=27424798 10 4e-30 0.0295004 0.0976 0.589 0.57-0.61 OR 4.54 3.07-6.71 4.54 3.07-6.71 3 2.17-4.14 3 2.17-4.14 2.48 1.98-3.12 2.48 1.98-3.12 2.13 1.78-2.55 2.13 1.78-2.55 1.87 1.62-2.15 1.87 1.62-2.15 1.26 1.01-1.57 0.0386 1.58 1.28-1.94 2.12e-05 2.42 1.98-2.95 4.09e-18 TRUE FALSE FALSE TRUE Both 982 7491 GRCh37/hg19 P<=5e-08 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000465/ScoringFiles/ phewas/PRSWEB_PHECODE172.22_cSCC-Chahal_P_5e-08_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE172.22_cSCC-Chahal_P_5e-08_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode172-22-gwas-catalog-r2019-05-03-x172-22-pt-mgi-20200608 prsweb-phecode172-22-gwas-catalog-r2019-05-03-x172-22-pt-mgi-20200608 PRSWEB_PHECODE172.22_GWAS-Catalog-r2019-05-03-X172.22_PT_MGI_20200608 P&T PRSWEB_PHECODE172.22_GWAS-Catalog-r2019-05-03-X172.22_PT_MGI_20200608 172.22 Squamous cell carcinoma;Cutaneous squamous cell carcinoma Binary 19 unique SNPs MGI Michigan Genomics Initiative P&T GWAS Catalog (2019-05-03) 26829030;26908436;27424798 https://www.ncbi.nlm.nih.gov/pubmed/?term=26829030+26908436+27424798 7 2.3e-28 0.0297042 0.0977 0.593 0.573-0.613 OR 3.74 2.46-5.68 3.74 2.46-5.68 2.87 2.07-3.97 2.87 2.07-3.97 2.45 1.95-3.08 2.45 1.95-3.08 2.28 1.91-2.72 2.28 1.91-2.72 1.95 1.69-2.24 1.95 1.69-2.24 1.45 1.17-1.8 0.000805 1.52 1.23-1.88 0.000138 2.57 2.11-3.14 2.31e-20 TRUE FALSE FALSE TRUE Both 982 7491 GRCh37/hg19 P<=1e-11 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000463/ScoringFiles/ phewas/PRSWEB_PHECODE172.22_GWAS-Catalog-r2019-05-03-X172.22_PT_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE172.22_GWAS-Catalog-r2019-05-03-X172.22_PT_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode172-22-cscc-chahal-pt-mgi-20200608 prsweb-phecode172-22-cscc-chahal-pt-mgi-20200608 PRSWEB_PHECODE172.22_cSCC-Chahal_PT_MGI_20200608 P&T PRSWEB_PHECODE172.22_cSCC-Chahal_PT_MGI_20200608 172.22 Squamous cell carcinoma Binary known and novel MGI Michigan Genomics Initiative P&T Chahal HS et al. 2018 27424798 https://www.ncbi.nlm.nih.gov/pubmed/?term=27424798 6 1.2e-27 0.0314978 0.0978 0.583 0.564-0.603 OR 3.75 2.49-5.64 3.75 2.49-5.64 3.3 2.41-4.5 3.3 2.41-4.5 2.36 1.87-2.97 2.36 1.87-2.97 2.07 1.73-2.49 2.07 1.73-2.49 1.87 1.63-2.16 1.87 1.63-2.16 1.08 0.868-1.34 0.498 1.45 1.18-1.78 0.000428 2.19 1.8-2.66 2.4e-15 TRUE FALSE FALSE TRUE Both 982 7491 GRCh37/hg19 P<=7.94e-09 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000467/ScoringFiles/ phewas/PRSWEB_PHECODE172.22_cSCC-Chahal_PT_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE172.22_cSCC-Chahal_PT_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode172-22-20001-1062-prs-cs-mgi-20200608 prsweb-phecode172-22-20001-1062-prs-cs-mgi-20200608 PRSWEB_PHECODE172.22_20001-1062_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE172.22_20001-1062_PRS-CS_MGI_20200608 172.22 Cancer code, self-reported: squamous cell carcinoma Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative PRS-CS UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1064109 0.15 0.000162382 0.0997 0.512 0.493-0.532 OR 1.67 0.961-2.89 1.67 0.961-2.89 1.14 0.721-1.79 1.14 0.721-1.79 1.15 0.86-1.54 1.15 0.86-1.54 1.23 0.997-1.52 1.23 0.997-1.52 1.12 0.966-1.31 1.12 0.966-1.31 0.815 0.67-0.99 0.0395 0.989 0.82-1.19 0.909 1.04 0.862-1.25 0.706 FALSE FALSE FALSE FALSE Both 982 7491 GRCh37/hg19 auto 2020-06-08 prsweb-phecode172-22-20001-1062-lassosum-mgi-20200608 prsweb-phecode172-22-20001-1062-lassosum-mgi-20200608 PRSWEB_PHECODE172.22_20001-1062_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE172.22_20001-1062_LASSOSUM_MGI_20200608 172.22 Cancer code, self-reported: squamous cell carcinoma Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative lassosum UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 4279140 0.0076 0.00050461 0.0996 0.523 0.503-0.543 OR 1.56 0.892-2.74 1.56 0.892-2.74 1.47 0.971-2.22 1.47 0.971-2.22 1.5 1.15-1.95 1.5 1.15-1.95 1.23 0.994-1.51 1.23 0.994-1.51 1.18 1.02-1.37 1.18 1.02-1.37 0.945 0.778-1.15 0.572 1.05 0.87-1.28 0.594 1.18 0.98-1.42 0.0802 TRUE FALSE FALSE TRUE Both 982 7491 GRCh37/hg19 s=1;Lambda=0.00336 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000460/ScoringFiles/ phewas/PRSWEB_PHECODE172.22_20001-1062_LASSOSUM_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE172.22_20001-1062_LASSOSUM_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode172-22-gwas-catalog-r2019-05-03-x172-22-p-5e-05-ukb-20200608 prsweb-phecode172-22-gwas-catalog-r2019-05-03-x172-22-p-5e-05-ukb-20200608 PRSWEB_PHECODE172.22_GWAS-Catalog-r2019-05-03-X172.22_P_5e-05_UKB_20200608 P_5e-05 PRSWEB_PHECODE172.22_GWAS-Catalog-r2019-05-03-X172.22_P_5e-05_UKB_20200608 172.22 Squamous cell carcinoma;Cutaneous squamous cell carcinoma Binary 19 unique SNPs UKB UK Biobank Fixed threshold (5e-05) GWAS Catalog (2019-05-03) 26829030;26908436;27424798 https://www.ncbi.nlm.nih.gov/pubmed/?term=26829030+26908436+27424798 18 1.6e-57 0.0110016 0.0822 0.558 0.551-0.566 OR 1.6 1.27-2.01 1.6 1.27-2.01 1.69 1.44-1.98 1.69 1.44-1.98 1.63 1.46-1.81 1.63 1.46-1.81 1.52 1.41-1.65 1.52 1.41-1.65 1.43 1.35-1.52 1.43 1.35-1.52 1.23 1.13-1.35 1.96e-06 1.49 1.37-1.62 2.44e-20 1.76 1.62-1.91 1.17e-41 TRUE FALSE FALSE FALSE Both 5450 54568 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode172-22-cscc-chahal-p-5e-05-ukb-20200608 prsweb-phecode172-22-cscc-chahal-p-5e-05-ukb-20200608 PRSWEB_PHECODE172.22_cSCC-Chahal_P_5e-05_UKB_20200608 P_5e-05 PRSWEB_PHECODE172.22_cSCC-Chahal_P_5e-05_UKB_20200608 172.22 Squamous cell carcinoma Binary known and novel UKB UK Biobank Fixed threshold (5e-05) Chahal HS et al. 2018 27424798 https://www.ncbi.nlm.nih.gov/pubmed/?term=27424798 10 4.3e-94 0.0139988 0.082 0.57 0.562-0.578 OR 1.75 1.4-2.18 1.75 1.4-2.18 1.79 1.53-2.09 1.79 1.53-2.09 1.83 1.65-2.02 1.83 1.65-2.02 1.77 1.64-1.91 1.77 1.64-1.91 1.66 1.57-1.76 1.66 1.57-1.76 1.18 1.08-1.29 0.000286 1.47 1.35-1.6 1.23e-19 1.99 1.84-2.15 1.14e-63 TRUE FALSE FALSE FALSE Both 5450 54568 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode172-22-gwas-catalog-r2019-05-03-x172-22-p-5e-06-ukb-20200608 prsweb-phecode172-22-gwas-catalog-r2019-05-03-x172-22-p-5e-06-ukb-20200608 PRSWEB_PHECODE172.22_GWAS-Catalog-r2019-05-03-X172.22_P_5e-06_UKB_20200608 P_5e-06 PRSWEB_PHECODE172.22_GWAS-Catalog-r2019-05-03-X172.22_P_5e-06_UKB_20200608 172.22 Squamous cell carcinoma;Cutaneous squamous cell carcinoma Binary 19 unique SNPs UKB UK Biobank Fixed threshold (5e-06) GWAS Catalog (2019-05-03) 26829030;26908436;27424798 https://www.ncbi.nlm.nih.gov/pubmed/?term=26829030+26908436+27424798 17 1.7e-66 0.011696 0.0822 0.562 0.555-0.571 OR 1.65 1.32-2.07 1.65 1.32-2.07 1.61 1.37-1.9 1.61 1.37-1.9 1.65 1.48-1.83 1.65 1.48-1.83 1.59 1.47-1.73 1.59 1.47-1.73 1.49 1.4-1.58 1.49 1.4-1.58 1.32 1.21-1.44 5.26e-10 1.52 1.4-1.66 7.5e-22 1.89 1.74-2.06 1.77e-51 TRUE FALSE FALSE FALSE Both 5450 54568 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode172-22-cscc-chahal-p-5e-06-ukb-20200608 prsweb-phecode172-22-cscc-chahal-p-5e-06-ukb-20200608 PRSWEB_PHECODE172.22_cSCC-Chahal_P_5e-06_UKB_20200608 P_5e-06 PRSWEB_PHECODE172.22_cSCC-Chahal_P_5e-06_UKB_20200608 172.22 Squamous cell carcinoma Binary known and novel UKB UK Biobank Fixed threshold (5e-06) Chahal HS et al. 2018 27424798 https://www.ncbi.nlm.nih.gov/pubmed/?term=27424798 10 4.3e-94 0.0139988 0.082 0.57 0.562-0.578 OR 1.75 1.4-2.18 1.75 1.4-2.18 1.79 1.53-2.09 1.79 1.53-2.09 1.83 1.65-2.02 1.83 1.65-2.02 1.77 1.64-1.91 1.77 1.64-1.91 1.66 1.57-1.76 1.66 1.57-1.76 1.18 1.08-1.29 0.000286 1.47 1.35-1.6 1.23e-19 1.99 1.84-2.15 1.14e-63 TRUE FALSE FALSE FALSE Both 5450 54568 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode172-22-gwas-catalog-r2019-05-03-x172-22-p-5e-07-ukb-20200608 prsweb-phecode172-22-gwas-catalog-r2019-05-03-x172-22-p-5e-07-ukb-20200608 PRSWEB_PHECODE172.22_GWAS-Catalog-r2019-05-03-X172.22_P_5e-07_UKB_20200608 P_5e-07 PRSWEB_PHECODE172.22_GWAS-Catalog-r2019-05-03-X172.22_P_5e-07_UKB_20200608 172.22 Squamous cell carcinoma;Cutaneous squamous cell carcinoma Binary 19 unique SNPs UKB UK Biobank Fixed threshold (5e-07) GWAS Catalog (2019-05-03) 26829030;26908436;27424798 https://www.ncbi.nlm.nih.gov/pubmed/?term=26829030+26908436+27424798 14 4.1e-93 0.0148476 0.082 0.575 0.567-0.582 OR 2.19 1.79-2.67 2.19 1.79-2.67 1.89 1.62-2.2 1.89 1.62-2.2 1.82 1.65-2.02 1.82 1.65-2.02 1.71 1.58-1.85 1.71 1.58-1.85 1.62 1.53-1.72 1.62 1.53-1.72 1.34 1.22-1.46 2.92e-10 1.67 1.53-1.82 6.99e-31 2.15 1.97-2.33 7.5e-71 TRUE FALSE FALSE FALSE Both 5450 54568 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode172-22-cscc-chahal-p-5e-07-ukb-20200608 prsweb-phecode172-22-cscc-chahal-p-5e-07-ukb-20200608 PRSWEB_PHECODE172.22_cSCC-Chahal_P_5e-07_UKB_20200608 P_5e-07 PRSWEB_PHECODE172.22_cSCC-Chahal_P_5e-07_UKB_20200608 172.22 Squamous cell carcinoma Binary known and novel UKB UK Biobank Fixed threshold (5e-07) Chahal HS et al. 2018 27424798 https://www.ncbi.nlm.nih.gov/pubmed/?term=27424798 10 4.3e-94 0.0139988 0.082 0.57 0.562-0.578 OR 1.75 1.4-2.18 1.75 1.4-2.18 1.79 1.53-2.09 1.79 1.53-2.09 1.83 1.65-2.02 1.83 1.65-2.02 1.77 1.64-1.91 1.77 1.64-1.91 1.66 1.57-1.76 1.66 1.57-1.76 1.18 1.08-1.29 0.000286 1.47 1.35-1.6 1.23e-19 1.99 1.84-2.15 1.14e-63 TRUE FALSE FALSE FALSE Both 5450 54568 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode172-22-gwas-catalog-r2019-05-03-x172-22-p-5e-09-ukb-20200608 prsweb-phecode172-22-gwas-catalog-r2019-05-03-x172-22-p-5e-09-ukb-20200608 PRSWEB_PHECODE172.22_GWAS-Catalog-r2019-05-03-X172.22_P_5e-09_UKB_20200608 P_5e-09 PRSWEB_PHECODE172.22_GWAS-Catalog-r2019-05-03-X172.22_P_5e-09_UKB_20200608 172.22 Squamous cell carcinoma;Cutaneous squamous cell carcinoma Binary 19 unique SNPs UKB UK Biobank Fixed threshold (5e-09) GWAS Catalog (2019-05-03) 26829030;26908436;27424798 https://www.ncbi.nlm.nih.gov/pubmed/?term=26829030+26908436+27424798 7 2.1e-85 0.0131787 0.082 0.57 0.563-0.578 OR 1.86 1.5-2.3 1.86 1.5-2.3 1.97 1.69-2.29 1.97 1.69-2.29 1.79 1.62-1.99 1.79 1.62-1.99 1.67 1.55-1.81 1.67 1.55-1.81 1.57 1.48-1.67 1.57 1.48-1.67 1.27 1.16-1.39 1.88e-07 1.61 1.48-1.75 5.33e-28 2 1.85-2.18 6.66e-61 TRUE FALSE FALSE FALSE Both 5450 54568 GRCh37/hg19 P<=5e-09 2020-06-08 prsweb-phecode172-22-cscc-chahal-p-5e-09-ukb-20200608 prsweb-phecode172-22-cscc-chahal-p-5e-09-ukb-20200608 PRSWEB_PHECODE172.22_cSCC-Chahal_P_5e-09_UKB_20200608 P_5e-09 PRSWEB_PHECODE172.22_cSCC-Chahal_P_5e-09_UKB_20200608 172.22 Squamous cell carcinoma Binary known and novel UKB UK Biobank Fixed threshold (5e-09) Chahal HS et al. 2018 27424798 https://www.ncbi.nlm.nih.gov/pubmed/?term=27424798 5 7.9e-97 0.013663 0.0819 0.569 0.561-0.577 OR 2.13 1.73-2.61 2.13 1.73-2.61 2.06 1.78-2.39 2.06 1.78-2.39 1.93 1.75-2.14 1.93 1.75-2.14 1.82 1.69-1.97 1.82 1.69-1.97 1.62 1.53-1.71 1.62 1.53-1.71 1.31 1.2-1.44 5.04e-09 1.47 1.36-1.58 9.7e-24 2.05 1.91-2.21 5.07e-79 TRUE FALSE FALSE FALSE Both 5450 54568 GRCh37/hg19 P<=5e-09 2020-06-08 prsweb-phecode172-22-gwas-catalog-r2019-05-03-x172-22-p-5e-08-ukb-20200608 prsweb-phecode172-22-gwas-catalog-r2019-05-03-x172-22-p-5e-08-ukb-20200608 PRSWEB_PHECODE172.22_GWAS-Catalog-r2019-05-03-X172.22_P_5e-08_UKB_20200608 P_5e-08 PRSWEB_PHECODE172.22_GWAS-Catalog-r2019-05-03-X172.22_P_5e-08_UKB_20200608 172.22 Squamous cell carcinoma;Cutaneous squamous cell carcinoma Binary 19 unique SNPs UKB UK Biobank GWAS Hits GWAS Catalog (2019-05-03) 26829030;26908436;27424798 https://www.ncbi.nlm.nih.gov/pubmed/?term=26829030+26908436+27424798 13 4.2e-89 0.0143482 0.082 0.573 0.564-0.58 OR 2.13 1.74-2.61 2.13 1.74-2.61 1.85 1.58-2.16 1.85 1.58-2.16 1.78 1.6-1.97 1.78 1.6-1.97 1.66 1.53-1.8 1.66 1.53-1.8 1.62 1.52-1.71 1.62 1.52-1.71 1.4 1.28-1.53 3.03e-13 1.63 1.49-1.78 4.32e-28 2.14 1.97-2.33 4.38e-70 TRUE FALSE FALSE TRUE Both 5450 54568 GRCh37/hg19 P<=5e-08 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000462/ScoringFiles/ phewas/PRSWEB_PHECODE172.22_GWAS-Catalog-r2019-05-03-X172.22_P_5e-08_UKB_20200608/all.tsv phewas/PRSWEB_PHECODE172.22_GWAS-Catalog-r2019-05-03-X172.22_P_5e-08_UKB_20200608/exclusion.tsv 2020-06-08 prsweb-phecode172-22-cscc-chahal-p-5e-08-ukb-20200608 prsweb-phecode172-22-cscc-chahal-p-5e-08-ukb-20200608 PRSWEB_PHECODE172.22_cSCC-Chahal_P_5e-08_UKB_20200608 P_5e-08 PRSWEB_PHECODE172.22_cSCC-Chahal_P_5e-08_UKB_20200608 172.22 Squamous cell carcinoma Binary known and novel UKB UK Biobank GWAS Hits Chahal HS et al. 2018 27424798 https://www.ncbi.nlm.nih.gov/pubmed/?term=27424798 10 4.3e-94 0.0139988 0.082 0.57 0.562-0.578 OR 1.75 1.4-2.18 1.75 1.4-2.18 1.79 1.53-2.09 1.79 1.53-2.09 1.83 1.65-2.02 1.83 1.65-2.02 1.77 1.64-1.91 1.77 1.64-1.91 1.66 1.57-1.76 1.66 1.57-1.76 1.18 1.08-1.29 0.000286 1.47 1.35-1.6 1.23e-19 1.99 1.84-2.15 1.14e-63 TRUE FALSE FALSE TRUE Both 5450 54568 GRCh37/hg19 P<=5e-08 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000466/ScoringFiles/ phewas/PRSWEB_PHECODE172.22_cSCC-Chahal_P_5e-08_UKB_20200608/all.tsv phewas/PRSWEB_PHECODE172.22_cSCC-Chahal_P_5e-08_UKB_20200608/exclusion.tsv 2020-06-08 prsweb-phecode172-22-gwas-catalog-r2019-05-03-x172-22-pt-ukb-20200608 prsweb-phecode172-22-gwas-catalog-r2019-05-03-x172-22-pt-ukb-20200608 PRSWEB_PHECODE172.22_GWAS-Catalog-r2019-05-03-X172.22_PT_UKB_20200608 P&T PRSWEB_PHECODE172.22_GWAS-Catalog-r2019-05-03-X172.22_PT_UKB_20200608 172.22 Squamous cell carcinoma;Cutaneous squamous cell carcinoma Binary 19 unique SNPs UKB UK Biobank P&T GWAS Catalog (2019-05-03) 26829030;26908436;27424798 https://www.ncbi.nlm.nih.gov/pubmed/?term=26829030+26908436+27424798 14 4.1e-93 0.0148476 0.082 0.575 0.567-0.582 OR 2.19 1.79-2.67 2.19 1.79-2.67 1.89 1.62-2.2 1.89 1.62-2.2 1.82 1.65-2.02 1.82 1.65-2.02 1.71 1.58-1.85 1.71 1.58-1.85 1.62 1.53-1.72 1.62 1.53-1.72 1.34 1.22-1.46 2.92e-10 1.67 1.53-1.82 6.99e-31 2.15 1.97-2.33 7.5e-71 TRUE FALSE FALSE TRUE Both 5450 54568 GRCh37/hg19 P<=1e-07 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000464/ScoringFiles/ phewas/PRSWEB_PHECODE172.22_GWAS-Catalog-r2019-05-03-X172.22_PT_UKB_20200608/all.tsv phewas/PRSWEB_PHECODE172.22_GWAS-Catalog-r2019-05-03-X172.22_PT_UKB_20200608/exclusion.tsv 2020-06-08 prsweb-phecode172-22-cscc-chahal-pt-ukb-20200608 prsweb-phecode172-22-cscc-chahal-pt-ukb-20200608 PRSWEB_PHECODE172.22_cSCC-Chahal_PT_UKB_20200608 P&T PRSWEB_PHECODE172.22_cSCC-Chahal_PT_UKB_20200608 172.22 Squamous cell carcinoma Binary known and novel UKB UK Biobank P&T Chahal HS et al. 2018 27424798 https://www.ncbi.nlm.nih.gov/pubmed/?term=27424798 9 3.6e-97 0.0144119 0.0819 0.571 0.563-0.579 OR 1.93 1.56-2.39 1.93 1.56-2.39 1.94 1.66-2.25 1.94 1.66-2.25 1.87 1.69-2.07 1.87 1.69-2.07 1.76 1.63-1.9 1.76 1.63-1.9 1.67 1.58-1.78 1.67 1.58-1.78 1.21 1.1-1.32 3.93e-05 1.51 1.38-1.64 6.31e-21 2.03 1.87-2.21 6.66e-64 TRUE FALSE FALSE TRUE Both 5450 54568 GRCh37/hg19 P<=1.58e-08 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000468/ScoringFiles/ phewas/PRSWEB_PHECODE172.22_cSCC-Chahal_PT_UKB_20200608/all.tsv phewas/PRSWEB_PHECODE172.22_cSCC-Chahal_PT_UKB_20200608/exclusion.tsv 2020-06-08 prsweb-phecode172-3-d04-p-5e-05-mgi-20200608 prsweb-phecode172-3-d04-p-5e-05-mgi-20200608 PRSWEB_PHECODE172.3_D04_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE172.3_D04_P_5e-05_MGI_20200608 172.3 Diagnoses - main ICD10: D04 Carcinoma in situ of skin Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 92 0.73 0.00105754 0.094 0.498 0.475-0.522 OR 0.768 0.289-2.05 0.768 0.289-2.05 1.19 0.664-2.12 1.19 0.664-2.12 1.23 0.857-1.78 1.23 0.857-1.78 0.963 0.72-1.29 0.963 0.72-1.29 0.942 0.77-1.15 0.942 0.77-1.15 1.2 0.943-1.53 0.137 1.15 0.895-1.47 0.281 1.05 0.817-1.35 0.7 FALSE FALSE FALSE FALSE Both 585 4915 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode172-3-ukbb-saige-hrc-x172-3-p-5e-05-mgi-20200608 prsweb-phecode172-3-ukbb-saige-hrc-x172-3-p-5e-05-mgi-20200608 PRSWEB_PHECODE172.3_UKBB-SAIGE-HRC-X172.3_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE172.3_UKBB-SAIGE-HRC-X172.3_P_5e-05_MGI_20200608 172.3 Carcinoma in situ of skin Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 99 0.0011 0.00623408 0.0938 0.535 0.511-0.559 OR 1.9 1.01-3.58 1.9 1.01-3.58 1.57 0.955-2.59 1.57 0.955-2.59 1.2 0.84-1.73 1.2 0.84-1.73 1.22 0.93-1.59 1.22 0.93-1.59 1.26 1.05-1.53 1.26 1.05-1.53 1.33 1.03-1.71 0.0298 1.32 1.02-1.71 0.0346 1.53 1.19-1.96 0.000909 TRUE FALSE FALSE FALSE Both 585 4915 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode172-3-d04-p-5e-06-mgi-20200608 prsweb-phecode172-3-d04-p-5e-06-mgi-20200608 PRSWEB_PHECODE172.3_D04_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE172.3_D04_P_5e-06_MGI_20200608 172.3 Diagnoses - main ICD10: D04 Carcinoma in situ of skin Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 12 0.25 0.000585282 0.094 0.499 0.474-0.524 OR 1.46 0.693-3.07 1.46 0.693-3.07 1.39 0.817-2.37 1.39 0.817-2.37 1.3 0.91-1.86 1.3 0.91-1.86 1.17 0.89-1.53 1.17 0.89-1.53 1.09 0.898-1.33 1.09 0.898-1.33 1.08 0.842-1.38 0.556 1.02 0.796-1.31 0.872 1.13 0.884-1.44 0.332 FALSE FALSE FALSE FALSE Both 585 4915 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode172-3-ukbb-saige-hrc-x172-3-p-5e-06-mgi-20200608 prsweb-phecode172-3-ukbb-saige-hrc-x172-3-p-5e-06-mgi-20200608 PRSWEB_PHECODE172.3_UKBB-SAIGE-HRC-X172.3_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE172.3_UKBB-SAIGE-HRC-X172.3_P_5e-06_MGI_20200608 172.3 Carcinoma in situ of skin Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 14 6.2e-08 0.0124194 0.0934 0.556 0.531-0.583 OR 2.47 1.35-4.5 2.47 1.35-4.5 2.12 1.34-3.35 2.12 1.34-3.35 1.7 1.22-2.35 1.7 1.22-2.35 1.56 1.22-2.01 1.56 1.22-2.01 1.62 1.35-1.94 1.62 1.35-1.94 1.29 0.992-1.68 0.057 1.26 0.966-1.64 0.0884 1.93 1.5-2.47 2.06e-07 TRUE FALSE FALSE FALSE Both 585 4915 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode172-3-ukbb-saige-hrc-x172-3-p-5e-07-mgi-20200608 prsweb-phecode172-3-ukbb-saige-hrc-x172-3-p-5e-07-mgi-20200608 PRSWEB_PHECODE172.3_UKBB-SAIGE-HRC-X172.3_P_5e-07_MGI_20200608 P_5e-07 PRSWEB_PHECODE172.3_UKBB-SAIGE-HRC-X172.3_P_5e-07_MGI_20200608 172.3 Carcinoma in situ of skin Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative Fixed threshold (5e-07) UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 5 3.9e-11 0.0262057 0.093 0.557 0.531-0.582 OR 2.45 1.34-4.45 2.45 1.34-4.45 2.8 1.85-4.24 2.8 1.85-4.24 2.55 1.92-3.39 2.55 1.92-3.39 1.87 1.48-2.37 1.87 1.48-2.37 1.71 1.43-2.05 1.71 1.43-2.05 1.23 0.944-1.61 0.124 1.27 0.97-1.65 0.0826 2 1.57-2.56 3.04e-08 TRUE FALSE FALSE FALSE Both 585 4915 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode172-3-d04-pt-mgi-20200608 prsweb-phecode172-3-d04-pt-mgi-20200608 PRSWEB_PHECODE172.3_D04_PT_MGI_20200608 P&T PRSWEB_PHECODE172.3_D04_PT_MGI_20200608 172.3 Diagnoses - main ICD10: D04 Carcinoma in situ of skin Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative P&T UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 65 0.43 0.00206257 0.094 0.503 0.479-0.528 OR 0.9 0.368-2.2 0.9 0.368-2.2 0.742 0.365-1.51 0.742 0.365-1.51 0.938 0.625-1.41 0.938 0.625-1.41 1.13 0.859-1.49 1.13 0.859-1.49 1.12 0.919-1.35 1.12 0.919-1.35 1.05 0.823-1.34 0.688 1.01 0.787-1.29 0.942 1.14 0.891-1.45 0.306 FALSE FALSE FALSE FALSE Both 585 4915 GRCh37/hg19 P<=3.16e-05 2020-06-08 prsweb-phecode172-3-ukbb-saige-hrc-x172-3-pt-mgi-20200608 prsweb-phecode172-3-ukbb-saige-hrc-x172-3-pt-mgi-20200608 PRSWEB_PHECODE172.3_UKBB-SAIGE-HRC-X172.3_PT_MGI_20200608 P&T PRSWEB_PHECODE172.3_UKBB-SAIGE-HRC-X172.3_PT_MGI_20200608 172.3 Carcinoma in situ of skin Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative P&T UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 5 3.9e-11 0.0262057 0.093 0.557 0.531-0.582 OR 2.45 1.34-4.45 2.45 1.34-4.45 2.8 1.85-4.24 2.8 1.85-4.24 2.55 1.92-3.39 2.55 1.92-3.39 1.87 1.48-2.37 1.87 1.48-2.37 1.71 1.43-2.05 1.71 1.43-2.05 1.23 0.944-1.61 0.124 1.27 0.97-1.65 0.0826 2 1.57-2.56 3.04e-08 TRUE FALSE FALSE TRUE Both 585 4915 GRCh37/hg19 P<=5e-07 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000470/ScoringFiles/ phewas/PRSWEB_PHECODE172.3_UKBB-SAIGE-HRC-X172.3_PT_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE172.3_UKBB-SAIGE-HRC-X172.3_PT_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode172-3-d04-prs-cs-mgi-20200608 prsweb-phecode172-3-d04-prs-cs-mgi-20200608 PRSWEB_PHECODE172.3_D04_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE172.3_D04_PRS-CS_MGI_20200608 172.3 Diagnoses - main ICD10: D04 Carcinoma in situ of skin Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative PRS-CS UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1065239 0.077 0.000107125 0.0939 0.521 0.495-0.546 OR 1.24 0.57-2.72 1.24 0.57-2.72 1.47 0.861-2.5 1.47 0.861-2.5 1.35 0.944-1.93 1.35 0.944-1.93 1.11 0.842-1.47 1.11 0.842-1.47 1.1 0.908-1.34 1.1 0.908-1.34 0.989 0.767-1.27 0.929 1.25 0.979-1.59 0.0744 1.17 0.912-1.49 0.221 FALSE FALSE FALSE FALSE Both 585 4915 GRCh37/hg19 auto 2020-06-08 prsweb-phecode172-3-ukbb-saige-hrc-x172-3-prs-cs-mgi-20200608 prsweb-phecode172-3-ukbb-saige-hrc-x172-3-prs-cs-mgi-20200608 PRSWEB_PHECODE172.3_UKBB-SAIGE-HRC-X172.3_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE172.3_UKBB-SAIGE-HRC-X172.3_PRS-CS_MGI_20200608 172.3 Carcinoma in situ of skin Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative PRS-CS UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1119238 0.048 0.00263471 0.0939 0.524 0.499-0.549 OR 1.48 0.703-3.1 1.48 0.703-3.1 1.46 0.855-2.49 1.46 0.855-2.49 1.33 0.927-1.9 1.33 0.927-1.9 1.2 0.913-1.57 1.2 0.913-1.57 1.22 1.01-1.47 1.22 1.01-1.47 1.25 0.972-1.6 0.0826 1.13 0.877-1.46 0.343 1.36 1.06-1.74 0.0142 TRUE FALSE FALSE TRUE Both 585 4915 GRCh37/hg19 auto https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000469/ScoringFiles/ phewas/PRSWEB_PHECODE172.3_UKBB-SAIGE-HRC-X172.3_PRS-CS_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE172.3_UKBB-SAIGE-HRC-X172.3_PRS-CS_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode172-3-d04-lassosum-mgi-20200608 prsweb-phecode172-3-d04-lassosum-mgi-20200608 PRSWEB_PHECODE172.3_D04_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE172.3_D04_LASSOSUM_MGI_20200608 172.3 Diagnoses - main ICD10: D04 Carcinoma in situ of skin Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative lassosum UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 118 0.51 0.00389185 0.094 0.504 0.48-0.528 OR 1.1 0.481-2.54 1.1 0.481-2.54 1.07 0.588-1.95 1.07 0.588-1.95 0.968 0.645-1.45 0.968 0.645-1.45 0.978 0.731-1.31 0.978 0.731-1.31 1.02 0.84-1.25 1.02 0.84-1.25 1.17 0.91-1.49 0.224 1.18 0.921-1.51 0.193 1.12 0.873-1.44 0.371 FALSE FALSE FALSE FALSE Both 585 4915 GRCh37/hg19 s=0.2;Lambda=0.1 2020-06-08 prsweb-phecode172-3-ukbb-saige-hrc-x172-3-lassosum-mgi-20200608 prsweb-phecode172-3-ukbb-saige-hrc-x172-3-lassosum-mgi-20200608 PRSWEB_PHECODE172.3_UKBB-SAIGE-HRC-X172.3_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE172.3_UKBB-SAIGE-HRC-X172.3_LASSOSUM_MGI_20200608 172.3 Carcinoma in situ of skin Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative lassosum UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 7 9.2e-18 0.0410713 0.0923 0.569 0.541-0.595 OR 3.77 2.24-6.34 3.77 2.24-6.34 3.17 2.12-4.75 3.17 2.12-4.75 2.89 2.21-3.78 2.89 2.21-3.78 2.35 1.88-2.93 2.35 1.88-2.93 1.84 1.54-2.21 1.84 1.54-2.21 1.05 0.71-1.54 0.823 1.22 0.827-1.79 0.319 1.98 1.37-2.87 0.00027 TRUE FALSE FALSE TRUE Both 585 4915 GRCh37/hg19 s=0.2;Lambda=0.1 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000471/ScoringFiles/ phewas/PRSWEB_PHECODE172.3_UKBB-SAIGE-HRC-X172.3_LASSOSUM_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE172.3_UKBB-SAIGE-HRC-X172.3_LASSOSUM_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode174-1-20001-1002-p-5e-05-mgi-20200608 prsweb-phecode174-1-20001-1002-p-5e-05-mgi-20200608 PRSWEB_PHECODE174.1_20001-1002_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE174.1_20001-1002_P_5e-05_MGI_20200608 174.1 Cancer code, self-reported: breast cancer Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 210 1.8e-18 0.0116583 0.138 0.576 0.559-0.593 OR 1.53 0.92-2.55 1.53 0.92-2.55 1.57 1.09-2.26 1.57 1.09-2.26 1.56 1.24-1.98 1.56 1.24-1.98 1.59 1.34-1.89 1.59 1.34-1.89 1.56 1.37-1.77 1.56 1.37-1.77 1.2 0.994-1.45 0.0582 1.61 1.35-1.93 1.75e-07 1.97 1.65-2.34 2.3e-14 TRUE FALSE FALSE FALSE Female 1341 6444 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode174-1-c3-breast-3-p-5e-05-mgi-20200608 prsweb-phecode174-1-c3-breast-3-p-5e-05-mgi-20200608 PRSWEB_PHECODE174.1_C3-BREAST-3_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE174.1_C3-BREAST-3_P_5e-05_MGI_20200608 174.1 Malignant neoplasm of breast Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 233 5.4e-24 0.0118695 0.138 0.586 0.57-0.603 OR 1.82 1.13-2.93 1.82 1.13-2.93 1.78 1.25-2.53 1.78 1.25-2.53 1.73 1.38-2.18 1.73 1.38-2.18 1.89 1.6-2.23 1.89 1.6-2.23 1.69 1.49-1.92 1.69 1.49-1.92 1.45 1.2-1.75 0.000122 1.69 1.4-2.04 3.11e-08 2.33 1.95-2.78 2.46e-20 TRUE FALSE FALSE FALSE Female 1341 6444 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode174-1-c50-p-5e-05-mgi-20200608 prsweb-phecode174-1-c50-p-5e-05-mgi-20200608 PRSWEB_PHECODE174.1_C50_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE174.1_C50_P_5e-05_MGI_20200608 174.1 Diagnoses - main ICD10: C50 Malignant neoplasm of breast Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 197 3e-21 0.00971314 0.138 0.584 0.567-0.601 OR 1.77 1.08-2.9 1.77 1.08-2.9 1.47 1.02-2.13 1.47 1.02-2.13 1.44 1.13-1.83 1.44 1.13-1.83 1.54 1.3-1.84 1.54 1.3-1.84 1.64 1.44-1.86 1.64 1.44-1.86 1.4 1.15-1.7 0.000634 1.82 1.52-2.19 1.91e-10 2.29 1.92-2.74 1.26e-19 TRUE FALSE FALSE FALSE Female 1341 6444 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode174-1-d05-p-5e-05-mgi-20200608 prsweb-phecode174-1-d05-p-5e-05-mgi-20200608 PRSWEB_PHECODE174.1_D05_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE174.1_D05_P_5e-05_MGI_20200608 174.1 Diagnoses - main ICD10: D05 Carcinoma in situ of breast Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 120 0.0055 0.000697087 0.14 0.517 0.499-0.534 OR 1.16 0.667-2.02 1.16 0.667-2.02 1.12 0.742-1.69 1.12 0.742-1.69 1.15 0.887-1.48 1.15 0.887-1.48 1.15 0.948-1.38 1.15 0.948-1.38 1.11 0.965-1.27 1.11 0.965-1.27 1.02 0.855-1.21 0.849 1.19 1-1.41 0.0449 1.18 0.998-1.4 0.0533 TRUE FALSE FALSE FALSE Female 1341 6444 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode174-1-gwas-catalog-r2019-05-03-x174-1-p-5e-05-mgi-20200608 prsweb-phecode174-1-gwas-catalog-r2019-05-03-x174-1-p-5e-05-mgi-20200608 PRSWEB_PHECODE174.1_GWAS-Catalog-r2019-05-03-X174.1_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE174.1_GWAS-Catalog-r2019-05-03-X174.1_P_5e-05_MGI_20200608 174.1 Breast cancer;Breast cancer (estrogen-receptor negative);Breast Cancer in BRCA1 mutation carriers;Breast cancer in BRCA2 mutation carriers Binary 136 unique SNPs MGI Michigan Genomics Initiative Fixed threshold (5e-05) GWAS Catalog (2019-05-03) 17529967;17529973;17529974;18326623;19330027;19330030;20453838;20852631;20872241;21263130;21424380;23354978;23535729;23535733;23544012;23544013;25751625;29058716;29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=17529967+17529973+17529974+18326623+19330027+19330030+20453838+20852631+20872241+21263130+21424380+23354978+23535729+23535733+23544012+23544013+25751625+29058716+29059683 62 5.2e-37 0.0207597 0.136 0.607 0.589-0.623 OR 3.06 2.04-4.6 3.06 2.04-4.6 2.35 1.71-3.24 2.35 1.71-3.24 2.21 1.79-2.74 2.21 1.79-2.74 2.26 1.93-2.65 2.26 1.93-2.65 1.9 1.68-2.16 1.9 1.68-2.16 1.45 1.2-1.77 0.000182 1.75 1.45-2.12 9.46e-09 2.68 2.23-3.21 1.95e-26 TRUE FALSE FALSE FALSE Female 1341 6444 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode174-1-onco-icogs-er-negative-brca-p-5e-05-mgi-20200608 prsweb-phecode174-1-onco-icogs-er-negative-brca-p-5e-05-mgi-20200608 PRSWEB_PHECODE174.1_Onco-iCOGS-ER-negative-BRCA_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE174.1_Onco-iCOGS-ER-negative-BRCA_P_5e-05_MGI_20200608 174.1 Breast cancer [female]; ER negative Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). MGI Michigan Genomics Initiative Fixed threshold (5e-05) Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 392 1.8e-18 0.00931451 0.138 0.575 0.557-0.592 OR 2.15 1.37-3.39 2.15 1.37-3.39 1.82 1.3-2.56 1.82 1.3-2.56 1.79 1.43-2.24 1.79 1.43-2.24 1.67 1.41-1.98 1.67 1.41-1.98 1.56 1.37-1.78 1.56 1.37-1.78 1.27 1.05-1.53 0.0123 1.53 1.28-1.84 3.78e-06 1.98 1.66-2.35 2.38e-14 TRUE FALSE FALSE FALSE Female 1341 6444 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode174-1-onco-icogs-er-positive-brca-p-5e-05-mgi-20200608 prsweb-phecode174-1-onco-icogs-er-positive-brca-p-5e-05-mgi-20200608 PRSWEB_PHECODE174.1_Onco-iCOGS-ER-positive-BRCA_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE174.1_Onco-iCOGS-ER-positive-BRCA_P_5e-05_MGI_20200608 174.1 Breast cancer [female]; ER positive Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). MGI Michigan Genomics Initiative Fixed threshold (5e-05) Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 950 6.5e-43 0.0347636 0.136 0.618 0.602-0.635 OR 2.91 1.93-4.4 2.91 1.93-4.4 2.65 1.96-3.6 2.65 1.96-3.6 2.27 1.84-2.8 2.27 1.84-2.8 2.21 1.88-2.59 2.21 1.88-2.59 2.11 1.87-2.39 2.11 1.87-2.39 1.48 1.21-1.82 0.000126 1.84 1.52-2.24 7.24e-10 3.01 2.51-3.62 4.62e-32 TRUE FALSE FALSE FALSE Female 1341 6444 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode174-1-onco-icogs-overall-brca-p-5e-05-mgi-20200608 prsweb-phecode174-1-onco-icogs-overall-brca-p-5e-05-mgi-20200608 PRSWEB_PHECODE174.1_Onco-iCOGS-Overall-BRCA_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE174.1_Onco-iCOGS-Overall-BRCA_P_5e-05_MGI_20200608 174.1 Breast cancer [female], Overall Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). MGI Michigan Genomics Initiative Fixed threshold (5e-05) Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 1307 1.9e-52 0.0391681 0.135 0.634 0.618-0.65 OR 2.75 1.81-4.17 2.75 1.81-4.17 2.93 2.18-3.94 2.93 2.18-3.94 2.76 2.26-3.37 2.76 2.26-3.37 2.66 2.28-3.11 2.66 2.28-3.11 2.22 1.96-2.52 2.22 1.96-2.52 1.42 1.15-1.75 0.00108 2.15 1.76-2.62 3.21e-14 3.29 2.72-3.96 1.49e-35 TRUE FALSE FALSE FALSE Female 1341 6444 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode174-1-ukbb-saige-hrc-x174-1-p-5e-05-mgi-20200608 prsweb-phecode174-1-ukbb-saige-hrc-x174-1-p-5e-05-mgi-20200608 PRSWEB_PHECODE174.1_UKBB-SAIGE-HRC-X174.1_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE174.1_UKBB-SAIGE-HRC-X174.1_P_5e-05_MGI_20200608 174.1 Breast cancer [female] Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 289 3.2e-29 0.0179676 0.137 0.597 0.581-0.613 OR 1.93 1.21-3.09 1.93 1.21-3.09 2.07 1.49-2.87 2.07 1.49-2.87 1.98 1.6-2.47 1.98 1.6-2.47 1.86 1.57-2.19 1.86 1.57-2.19 1.82 1.6-2.06 1.82 1.6-2.06 1.4 1.15-1.7 0.000741 1.78 1.47-2.15 1.95e-09 2.54 2.12-3.04 2.79e-24 TRUE FALSE FALSE FALSE Female 1341 6444 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode174-1-icogs-er-negative-brca-p-5e-05-mgi-20200608 prsweb-phecode174-1-icogs-er-negative-brca-p-5e-05-mgi-20200608 PRSWEB_PHECODE174.1_iCOGS-ER-negative-BRCA_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE174.1_iCOGS-ER-negative-BRCA_P_5e-05_MGI_20200608 174.1 Breast cancer [female]; ER negative Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). MGI Michigan Genomics Initiative Fixed threshold (5e-05) Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 158 4e-04 0.00222527 0.14 0.53 0.512-0.547 OR 1.53 0.917-2.54 1.53 0.917-2.54 1.28 0.865-1.89 1.28 0.865-1.89 1.23 0.956-1.59 1.23 0.956-1.59 1.24 1.03-1.49 1.24 1.03-1.49 1.27 1.11-1.45 1.27 1.11-1.45 0.984 0.825-1.17 0.853 1.11 0.935-1.32 0.233 1.31 1.11-1.54 0.00156 TRUE FALSE FALSE FALSE Female 1341 6444 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode174-1-icogs-er-positive-brca-p-5e-05-mgi-20200608 prsweb-phecode174-1-icogs-er-positive-brca-p-5e-05-mgi-20200608 PRSWEB_PHECODE174.1_iCOGS-ER-positive-BRCA_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE174.1_iCOGS-ER-positive-BRCA_P_5e-05_MGI_20200608 174.1 Breast cancer [female]; ER positive Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). MGI Michigan Genomics Initiative Fixed threshold (5e-05) Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 423 5.7e-27 0.0216201 0.137 0.592 0.576-0.61 OR 2.41 1.56-3.71 2.41 1.56-3.71 2.4 1.75-3.28 2.4 1.75-3.28 1.96 1.58-2.44 1.96 1.58-2.44 1.79 1.52-2.12 1.79 1.52-2.12 1.82 1.61-2.07 1.82 1.61-2.07 1.27 1.05-1.54 0.012 1.47 1.22-1.77 5.3e-05 2.25 1.9-2.68 3.37e-20 TRUE FALSE FALSE FALSE Female 1341 6444 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode174-1-icogs-overall-brca-p-5e-05-mgi-20200608 prsweb-phecode174-1-icogs-overall-brca-p-5e-05-mgi-20200608 PRSWEB_PHECODE174.1_iCOGS-Overall-BRCA_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE174.1_iCOGS-Overall-BRCA_P_5e-05_MGI_20200608 174.1 Breast cancer [female], Overall Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). MGI Michigan Genomics Initiative Fixed threshold (5e-05) Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 534 8.9e-35 0.0250961 0.137 0.608 0.591-0.625 OR 2.44 1.56-3.81 2.44 1.56-3.81 1.99 1.42-2.8 1.99 1.42-2.8 1.86 1.49-2.32 1.86 1.49-2.32 1.91 1.62-2.25 1.91 1.62-2.25 1.84 1.62-2.08 1.84 1.62-2.08 1.36 1.11-1.66 0.00299 2.1 1.74-2.54 1.47e-14 2.71 2.26-3.26 1.58e-26 TRUE FALSE FALSE FALSE Female 1341 6444 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode174-1-20001-1002-p-5e-06-mgi-20200608 prsweb-phecode174-1-20001-1002-p-5e-06-mgi-20200608 PRSWEB_PHECODE174.1_20001-1002_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE174.1_20001-1002_P_5e-06_MGI_20200608 174.1 Cancer code, self-reported: breast cancer Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 62 2.9e-21 0.0126436 0.138 0.58 0.562-0.597 OR 1.72 1.06-2.79 1.72 1.06-2.79 2.09 1.51-2.9 2.09 1.51-2.9 1.84 1.47-2.3 1.84 1.47-2.3 1.68 1.42-1.99 1.68 1.42-1.99 1.72 1.52-1.95 1.72 1.52-1.95 1.23 1.02-1.48 0.0303 1.43 1.19-1.72 0.000118 2.1 1.77-2.49 3.69e-17 TRUE FALSE FALSE FALSE Female 1341 6444 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode174-1-c3-breast-3-p-5e-06-mgi-20200608 prsweb-phecode174-1-c3-breast-3-p-5e-06-mgi-20200608 PRSWEB_PHECODE174.1_C3-BREAST-3_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE174.1_C3-BREAST-3_P_5e-06_MGI_20200608 174.1 Malignant neoplasm of breast Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 88 5.6e-28 0.0139773 0.137 0.594 0.577-0.611 OR 2.03 1.28-3.23 2.03 1.28-3.23 1.77 1.25-2.52 1.77 1.25-2.52 1.87 1.49-2.33 1.87 1.49-2.33 1.67 1.4-1.98 1.67 1.4-1.98 1.73 1.53-1.97 1.73 1.53-1.97 1.3 1.07-1.58 0.00836 1.74 1.45-2.09 3.42e-09 2.31 1.94-2.76 1.8e-20 TRUE FALSE FALSE FALSE Female 1341 6444 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode174-1-c50-p-5e-06-mgi-20200608 prsweb-phecode174-1-c50-p-5e-06-mgi-20200608 PRSWEB_PHECODE174.1_C50_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE174.1_C50_P_5e-06_MGI_20200608 174.1 Diagnoses - main ICD10: C50 Malignant neoplasm of breast Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 66 4.2e-24 0.0109453 0.138 0.585 0.568-0.601 OR 2.57 1.68-3.95 2.57 1.68-3.95 2 1.43-2.78 2 1.43-2.78 1.66 1.32-2.09 1.66 1.32-2.09 1.82 1.54-2.15 1.82 1.54-2.15 1.63 1.43-1.85 1.63 1.43-1.85 1.37 1.13-1.66 0.00137 1.75 1.46-2.11 2e-09 2.24 1.87-2.68 7.64e-19 TRUE FALSE FALSE FALSE Female 1341 6444 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode174-1-d05-p-5e-06-mgi-20200608 prsweb-phecode174-1-d05-p-5e-06-mgi-20200608 PRSWEB_PHECODE174.1_D05_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE174.1_D05_P_5e-06_MGI_20200608 174.1 Diagnoses - main ICD10: D05 Carcinoma in situ of breast Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 19 0.00016 0.00134743 0.139 0.519 0.502-0.536 OR 1.46 0.87-2.46 1.46 0.87-2.46 1.25 0.843-1.84 1.25 0.843-1.84 1.1 0.849-1.43 1.1 0.849-1.43 1.33 1.11-1.59 1.33 1.11-1.59 1.22 1.07-1.39 1.22 1.07-1.39 1.04 0.868-1.23 0.7 1.2 1.01-1.43 0.0333 1.32 1.11-1.56 0.0013 TRUE FALSE FALSE FALSE Female 1341 6444 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode174-1-gwas-catalog-r2019-05-03-x174-1-p-5e-06-mgi-20200608 prsweb-phecode174-1-gwas-catalog-r2019-05-03-x174-1-p-5e-06-mgi-20200608 PRSWEB_PHECODE174.1_GWAS-Catalog-r2019-05-03-X174.1_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE174.1_GWAS-Catalog-r2019-05-03-X174.1_P_5e-06_MGI_20200608 174.1 Breast cancer;Breast cancer (estrogen-receptor negative);Breast Cancer in BRCA1 mutation carriers;Breast cancer in BRCA2 mutation carriers Binary 136 unique SNPs MGI Michigan Genomics Initiative Fixed threshold (5e-06) GWAS Catalog (2019-05-03) 17529967;17529973;17529974;18326623;19330027;19330030;20453838;20852631;20872241;21263130;21424380;23354978;23535729;23535733;23544012;23544013;25751625;29058716;29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=17529967+17529973+17529974+18326623+19330027+19330030+20453838+20852631+20872241+21263130+21424380+23354978+23535729+23535733+23544012+23544013+25751625+29058716+29059683 62 5.2e-37 0.0207597 0.136 0.607 0.589-0.623 OR 3.06 2.04-4.6 3.06 2.04-4.6 2.35 1.71-3.24 2.35 1.71-3.24 2.21 1.79-2.74 2.21 1.79-2.74 2.26 1.93-2.65 2.26 1.93-2.65 1.9 1.68-2.16 1.9 1.68-2.16 1.45 1.2-1.77 0.000182 1.75 1.45-2.12 9.46e-09 2.68 2.23-3.21 1.95e-26 TRUE FALSE FALSE FALSE Female 1341 6444 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode174-1-onco-icogs-er-negative-brca-p-5e-06-mgi-20200608 prsweb-phecode174-1-onco-icogs-er-negative-brca-p-5e-06-mgi-20200608 PRSWEB_PHECODE174.1_Onco-iCOGS-ER-negative-BRCA_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE174.1_Onco-iCOGS-ER-negative-BRCA_P_5e-06_MGI_20200608 174.1 Breast cancer [female]; ER negative Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). MGI Michigan Genomics Initiative Fixed threshold (5e-06) Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 133 1.6e-16 0.00841717 0.138 0.569 0.552-0.587 OR 2.05 1.3-3.23 2.05 1.3-3.23 1.82 1.3-2.57 1.82 1.3-2.57 1.71 1.36-2.14 1.71 1.36-2.14 1.63 1.38-1.94 1.63 1.38-1.94 1.55 1.37-1.76 1.55 1.37-1.76 1.27 1.06-1.53 0.0109 1.43 1.19-1.72 0.00011 1.89 1.59-2.24 8.47e-13 TRUE FALSE FALSE FALSE Female 1341 6444 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode174-1-onco-icogs-er-positive-brca-p-5e-06-mgi-20200608 prsweb-phecode174-1-onco-icogs-er-positive-brca-p-5e-06-mgi-20200608 PRSWEB_PHECODE174.1_Onco-iCOGS-ER-positive-BRCA_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE174.1_Onco-iCOGS-ER-positive-BRCA_P_5e-06_MGI_20200608 174.1 Breast cancer [female]; ER positive Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). MGI Michigan Genomics Initiative Fixed threshold (5e-06) Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 495 2e-39 0.032 0.136 0.613 0.596-0.629 OR 2.29 1.47-3.56 2.29 1.47-3.56 2.2 1.59-3.04 2.2 1.59-3.04 2.35 1.9-2.89 2.35 1.9-2.89 2.05 1.74-2.41 2.05 1.74-2.41 1.89 1.67-2.15 1.89 1.67-2.15 1.4 1.14-1.7 0.00108 1.94 1.61-2.35 7.03e-12 2.71 2.26-3.25 6.27e-27 TRUE FALSE FALSE FALSE Female 1341 6444 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode174-1-onco-icogs-overall-brca-p-5e-06-mgi-20200608 prsweb-phecode174-1-onco-icogs-overall-brca-p-5e-06-mgi-20200608 PRSWEB_PHECODE174.1_Onco-iCOGS-Overall-BRCA_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE174.1_Onco-iCOGS-Overall-BRCA_P_5e-06_MGI_20200608 174.1 Breast cancer [female], Overall Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). MGI Michigan Genomics Initiative Fixed threshold (5e-06) Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 712 3.8e-49 0.0387775 0.135 0.629 0.612-0.645 OR 3.06 2.04-4.59 3.06 2.04-4.59 3.39 2.55-4.5 3.39 2.55-4.5 2.57 2.09-3.15 2.57 2.09-3.15 2.24 1.91-2.63 2.24 1.91-2.63 2.07 1.83-2.35 2.07 1.83-2.35 1.43 1.16-1.77 0.000711 2.23 1.84-2.71 5.14e-16 3.19 2.64-3.85 8.07e-34 TRUE FALSE FALSE FALSE Female 1341 6444 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode174-1-ukbb-saige-hrc-x174-1-p-5e-06-mgi-20200608 prsweb-phecode174-1-ukbb-saige-hrc-x174-1-p-5e-06-mgi-20200608 PRSWEB_PHECODE174.1_UKBB-SAIGE-HRC-X174.1_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE174.1_UKBB-SAIGE-HRC-X174.1_P_5e-06_MGI_20200608 174.1 Breast cancer [female] Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 109 3.3e-34 0.0169766 0.137 0.605 0.588-0.622 OR 2.21 1.41-3.45 2.21 1.41-3.45 2.63 1.94-3.57 2.63 1.94-3.57 1.97 1.58-2.45 1.97 1.58-2.45 1.79 1.51-2.12 1.79 1.51-2.12 1.98 1.74-2.24 1.98 1.74-2.24 1.51 1.24-1.83 4.47e-05 1.76 1.45-2.13 1.02e-08 2.79 2.33-3.35 1.09e-28 TRUE FALSE FALSE FALSE Female 1341 6444 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode174-1-icogs-er-negative-brca-p-5e-06-mgi-20200608 prsweb-phecode174-1-icogs-er-negative-brca-p-5e-06-mgi-20200608 PRSWEB_PHECODE174.1_iCOGS-ER-negative-BRCA_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE174.1_iCOGS-ER-negative-BRCA_P_5e-06_MGI_20200608 174.1 Breast cancer [female]; ER negative Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). MGI Michigan Genomics Initiative Fixed threshold (5e-06) Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 35 1.8e-09 0.00404105 0.139 0.546 0.528-0.561 OR 1.99 1.25-3.18 1.99 1.25-3.18 1.81 1.28-2.55 1.81 1.28-2.55 1.48 1.16-1.87 1.48 1.16-1.87 1.37 1.14-1.64 1.37 1.14-1.64 1.32 1.16-1.5 1.32 1.16-1.5 1.14 0.95-1.37 0.16 1.41 1.18-1.68 0.000111 1.55 1.31-1.84 5.36e-07 TRUE FALSE FALSE FALSE Female 1341 6444 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode174-1-icogs-er-positive-brca-p-5e-06-mgi-20200608 prsweb-phecode174-1-icogs-er-positive-brca-p-5e-06-mgi-20200608 PRSWEB_PHECODE174.1_iCOGS-ER-positive-BRCA_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE174.1_iCOGS-ER-positive-BRCA_P_5e-06_MGI_20200608 174.1 Breast cancer [female]; ER positive Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). MGI Michigan Genomics Initiative Fixed threshold (5e-06) Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 185 3.2e-33 0.0227923 0.137 0.601 0.584-0.617 OR 2.94 1.95-4.44 2.94 1.95-4.44 2.42 1.77-3.32 2.42 1.77-3.32 1.96 1.57-2.44 1.96 1.57-2.44 1.9 1.61-2.24 1.9 1.61-2.24 1.83 1.61-2.08 1.83 1.61-2.08 1.37 1.13-1.67 0.00168 1.85 1.54-2.24 1.18e-10 2.54 2.13-3.04 2.06e-24 TRUE FALSE FALSE FALSE Female 1341 6444 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode174-1-icogs-overall-brca-p-5e-06-mgi-20200608 prsweb-phecode174-1-icogs-overall-brca-p-5e-06-mgi-20200608 PRSWEB_PHECODE174.1_iCOGS-Overall-BRCA_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE174.1_iCOGS-Overall-BRCA_P_5e-06_MGI_20200608 174.1 Breast cancer [female], Overall Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). MGI Michigan Genomics Initiative Fixed threshold (5e-06) Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 246 1.2e-40 0.0251426 0.136 0.613 0.597-0.631 OR 2.8 1.85-4.25 2.8 1.85-4.25 2.23 1.62-3.08 2.23 1.62-3.08 2.07 1.67-2.57 2.07 1.67-2.57 2.11 1.79-2.48 2.11 1.79-2.48 2.03 1.79-2.3 2.03 1.79-2.3 1.46 1.2-1.79 0.00021 1.92 1.58-2.33 3.57e-11 2.96 2.47-3.56 3.62e-31 TRUE FALSE FALSE FALSE Female 1341 6444 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode174-1-20001-1002-p-5e-07-mgi-20200608 prsweb-phecode174-1-20001-1002-p-5e-07-mgi-20200608 PRSWEB_PHECODE174.1_20001-1002_P_5e-07_MGI_20200608 P_5e-07 PRSWEB_PHECODE174.1_20001-1002_P_5e-07_MGI_20200608 174.1 Cancer code, self-reported: breast cancer Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-07) UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 33 1.2e-22 0.00955433 0.138 0.581 0.564-0.598 OR 2.17 1.38-3.42 2.17 1.38-3.42 2.32 1.69-3.18 2.32 1.69-3.18 1.91 1.53-2.38 1.91 1.53-2.38 1.59 1.34-1.89 1.59 1.34-1.89 1.61 1.42-1.83 1.61 1.42-1.83 1.24 1.02-1.5 0.0271 1.71 1.43-2.05 5.82e-09 2.12 1.78-2.53 6.17e-17 TRUE FALSE FALSE FALSE Female 1341 6444 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode174-1-c3-breast-3-p-5e-07-mgi-20200608 prsweb-phecode174-1-c3-breast-3-p-5e-07-mgi-20200608 PRSWEB_PHECODE174.1_C3-BREAST-3_P_5e-07_MGI_20200608 P_5e-07 PRSWEB_PHECODE174.1_C3-BREAST-3_P_5e-07_MGI_20200608 174.1 Malignant neoplasm of breast Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-07) UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 45 1.3e-23 0.0100018 0.138 0.585 0.568-0.602 OR 2.22 1.43-3.46 2.22 1.43-3.46 1.86 1.32-2.6 1.86 1.32-2.6 1.89 1.52-2.37 1.89 1.52-2.37 1.63 1.37-1.94 1.63 1.37-1.94 1.64 1.44-1.86 1.64 1.44-1.86 1.29 1.07-1.57 0.00892 1.75 1.46-2.1 1.46e-09 2.21 1.85-2.63 1.56e-18 TRUE FALSE FALSE FALSE Female 1341 6444 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode174-1-c50-p-5e-07-mgi-20200608 prsweb-phecode174-1-c50-p-5e-07-mgi-20200608 PRSWEB_PHECODE174.1_C50_P_5e-07_MGI_20200608 P_5e-07 PRSWEB_PHECODE174.1_C50_P_5e-07_MGI_20200608 174.1 Diagnoses - main ICD10: C50 Malignant neoplasm of breast Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-07) UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 29 4.2e-23 0.010297 0.138 0.582 0.565-0.599 OR 1.85 1.16-2.96 1.85 1.16-2.96 1.9 1.36-2.67 1.9 1.36-2.67 1.66 1.32-2.09 1.66 1.32-2.09 1.64 1.38-1.95 1.64 1.38-1.95 1.66 1.47-1.89 1.66 1.47-1.89 1.49 1.23-1.8 5.13e-05 1.74 1.44-2.09 6.84e-09 2.33 1.94-2.78 2.63e-20 TRUE FALSE FALSE FALSE Female 1341 6444 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode174-1-gwas-catalog-r2019-05-03-x174-1-p-5e-07-mgi-20200608 prsweb-phecode174-1-gwas-catalog-r2019-05-03-x174-1-p-5e-07-mgi-20200608 PRSWEB_PHECODE174.1_GWAS-Catalog-r2019-05-03-X174.1_P_5e-07_MGI_20200608 P_5e-07 PRSWEB_PHECODE174.1_GWAS-Catalog-r2019-05-03-X174.1_P_5e-07_MGI_20200608 174.1 Breast cancer;Breast cancer (estrogen-receptor negative);Breast Cancer in BRCA1 mutation carriers;Breast cancer in BRCA2 mutation carriers Binary 136 unique SNPs MGI Michigan Genomics Initiative Fixed threshold (5e-07) GWAS Catalog (2019-05-03) 17529967;17529973;17529974;18326623;19330027;19330030;20453838;20852631;20872241;21263130;21424380;23354978;23535729;23535733;23544012;23544013;25751625;29058716;29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=17529967+17529973+17529974+18326623+19330027+19330030+20453838+20852631+20872241+21263130+21424380+23354978+23535729+23535733+23544012+23544013+25751625+29058716+29059683 62 5.2e-37 0.0207597 0.136 0.607 0.589-0.623 OR 3.06 2.04-4.6 3.06 2.04-4.6 2.35 1.71-3.24 2.35 1.71-3.24 2.21 1.79-2.74 2.21 1.79-2.74 2.26 1.93-2.65 2.26 1.93-2.65 1.9 1.68-2.16 1.9 1.68-2.16 1.45 1.2-1.77 0.000182 1.75 1.45-2.12 9.46e-09 2.68 2.23-3.21 1.95e-26 TRUE FALSE FALSE FALSE Female 1341 6444 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode174-1-onco-icogs-er-negative-brca-p-5e-07-mgi-20200608 prsweb-phecode174-1-onco-icogs-er-negative-brca-p-5e-07-mgi-20200608 PRSWEB_PHECODE174.1_Onco-iCOGS-ER-negative-BRCA_P_5e-07_MGI_20200608 P_5e-07 PRSWEB_PHECODE174.1_Onco-iCOGS-ER-negative-BRCA_P_5e-07_MGI_20200608 174.1 Breast cancer [female]; ER negative Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). MGI Michigan Genomics Initiative Fixed threshold (5e-07) Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 73 6.2e-12 0.0083856 0.139 0.557 0.54-0.574 OR 1.62 0.98-2.67 1.62 0.98-2.67 1.87 1.33-2.62 1.87 1.33-2.62 1.54 1.21-1.95 1.54 1.21-1.95 1.4 1.17-1.68 1.4 1.17-1.68 1.42 1.25-1.62 1.42 1.25-1.62 1.39 1.16-1.67 0.000418 1.53 1.28-1.84 4.1e-06 1.85 1.55-2.21 7.89e-12 TRUE FALSE FALSE FALSE Female 1341 6444 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode174-1-onco-icogs-er-positive-brca-p-5e-07-mgi-20200608 prsweb-phecode174-1-onco-icogs-er-positive-brca-p-5e-07-mgi-20200608 PRSWEB_PHECODE174.1_Onco-iCOGS-ER-positive-BRCA_P_5e-07_MGI_20200608 P_5e-07 PRSWEB_PHECODE174.1_Onco-iCOGS-ER-positive-BRCA_P_5e-07_MGI_20200608 174.1 Breast cancer [female]; ER positive Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). MGI Michigan Genomics Initiative Fixed threshold (5e-07) Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 343 3.9e-39 0.0302005 0.136 0.612 0.596-0.628 OR 2.47 1.6-3.81 2.47 1.6-3.81 2.28 1.66-3.15 2.28 1.66-3.15 2.18 1.76-2.7 2.18 1.76-2.7 2.2 1.88-2.59 2.2 1.88-2.59 1.88 1.66-2.13 1.88 1.66-2.13 1.23 1.01-1.5 0.0434 1.97 1.64-2.38 1.21e-12 2.6 2.17-3.11 2.13e-25 TRUE FALSE FALSE FALSE Female 1341 6444 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode174-1-onco-icogs-overall-brca-p-5e-07-mgi-20200608 prsweb-phecode174-1-onco-icogs-overall-brca-p-5e-07-mgi-20200608 PRSWEB_PHECODE174.1_Onco-iCOGS-Overall-BRCA_P_5e-07_MGI_20200608 P_5e-07 PRSWEB_PHECODE174.1_Onco-iCOGS-Overall-BRCA_P_5e-07_MGI_20200608 174.1 Breast cancer [female], Overall Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). MGI Michigan Genomics Initiative Fixed threshold (5e-07) Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 464 8e-49 0.0384567 0.135 0.627 0.611-0.644 OR 3.38 2.28-5.02 3.38 2.28-5.02 3.08 2.3-4.14 3.08 2.3-4.14 2.6 2.12-3.19 2.6 2.12-3.19 2.16 1.84-2.54 2.16 1.84-2.54 1.98 1.74-2.24 1.98 1.74-2.24 1.49 1.21-1.84 0.000165 2.37 1.95-2.88 6.45e-18 3.15 2.6-3.81 2.35e-32 TRUE FALSE FALSE FALSE Female 1341 6444 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode174-1-ukbb-saige-hrc-x174-1-p-5e-07-mgi-20200608 prsweb-phecode174-1-ukbb-saige-hrc-x174-1-p-5e-07-mgi-20200608 PRSWEB_PHECODE174.1_UKBB-SAIGE-HRC-X174.1_P_5e-07_MGI_20200608 P_5e-07 PRSWEB_PHECODE174.1_UKBB-SAIGE-HRC-X174.1_P_5e-07_MGI_20200608 174.1 Breast cancer [female] Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative Fixed threshold (5e-07) UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 64 1e-30 0.016038 0.137 0.6 0.584-0.617 OR 2.47 1.59-3.83 2.47 1.59-3.83 1.92 1.37-2.69 1.92 1.37-2.69 1.79 1.43-2.25 1.79 1.43-2.25 1.71 1.45-2.03 1.71 1.45-2.03 1.78 1.57-2.02 1.78 1.57-2.02 1.48 1.22-1.8 9.8e-05 1.94 1.61-2.35 6.24e-12 2.62 2.18-3.14 3.58e-25 TRUE FALSE FALSE FALSE Female 1341 6444 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode174-1-icogs-er-negative-brca-p-5e-07-mgi-20200608 prsweb-phecode174-1-icogs-er-negative-brca-p-5e-07-mgi-20200608 PRSWEB_PHECODE174.1_iCOGS-ER-negative-BRCA_P_5e-07_MGI_20200608 P_5e-07 PRSWEB_PHECODE174.1_iCOGS-ER-negative-BRCA_P_5e-07_MGI_20200608 174.1 Breast cancer [female]; ER negative Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). MGI Michigan Genomics Initiative Fixed threshold (5e-07) Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 14 2.1e-13 0.00713904 0.139 0.556 0.538-0.571 OR 1.69 1.03-2.76 1.69 1.03-2.76 1.87 1.33-2.64 1.87 1.33-2.64 1.54 1.22-1.95 1.54 1.22-1.95 1.51 1.27-1.8 1.51 1.27-1.8 1.49 1.31-1.7 1.49 1.31-1.7 1.32 1.1-1.58 0.00253 1.28 1.07-1.54 0.0072 1.8 1.51-2.13 2.88e-11 TRUE FALSE FALSE FALSE Female 1341 6444 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode174-1-icogs-er-positive-brca-p-5e-07-mgi-20200608 prsweb-phecode174-1-icogs-er-positive-brca-p-5e-07-mgi-20200608 PRSWEB_PHECODE174.1_iCOGS-ER-positive-BRCA_P_5e-07_MGI_20200608 P_5e-07 PRSWEB_PHECODE174.1_iCOGS-ER-positive-BRCA_P_5e-07_MGI_20200608 174.1 Breast cancer [female]; ER positive Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). MGI Michigan Genomics Initiative Fixed threshold (5e-07) Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 113 6.1e-32 0.020021 0.137 0.599 0.583-0.615 OR 2.49 1.61-3.85 2.49 1.61-3.85 2.2 1.59-3.05 2.2 1.59-3.05 2.06 1.66-2.56 2.06 1.66-2.56 1.87 1.58-2.21 1.87 1.58-2.21 1.71 1.51-1.94 1.71 1.51-1.94 1.39 1.14-1.69 0.000926 1.93 1.6-2.33 4.51e-12 2.45 2.04-2.93 2.85e-22 TRUE FALSE FALSE FALSE Female 1341 6444 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode174-1-icogs-overall-brca-p-5e-07-mgi-20200608 prsweb-phecode174-1-icogs-overall-brca-p-5e-07-mgi-20200608 PRSWEB_PHECODE174.1_iCOGS-Overall-BRCA_P_5e-07_MGI_20200608 P_5e-07 PRSWEB_PHECODE174.1_iCOGS-Overall-BRCA_P_5e-07_MGI_20200608 174.1 Breast cancer [female], Overall Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). MGI Michigan Genomics Initiative Fixed threshold (5e-07) Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 154 1.4e-40 0.0216537 0.136 0.614 0.598-0.63 OR 2.28 1.46-3.54 2.28 1.46-3.54 2.26 1.63-3.11 2.26 1.63-3.11 2.16 1.74-2.67 2.16 1.74-2.67 2 1.7-2.35 2 1.7-2.35 1.97 1.74-2.23 1.97 1.74-2.23 1.5 1.23-1.84 8.7e-05 2.05 1.69-2.49 3.34e-13 2.96 2.46-3.56 1.21e-30 TRUE FALSE FALSE FALSE Female 1341 6444 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode174-1-20001-1002-p-5e-09-mgi-20200608 prsweb-phecode174-1-20001-1002-p-5e-09-mgi-20200608 PRSWEB_PHECODE174.1_20001-1002_P_5e-09_MGI_20200608 P_5e-09 PRSWEB_PHECODE174.1_20001-1002_P_5e-09_MGI_20200608 174.1 Cancer code, self-reported: breast cancer Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-09) UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 18 1.1e-21 0.00807385 0.138 0.58 0.563-0.597 OR 1.86 1.15-2.99 1.86 1.15-2.99 1.83 1.3-2.57 1.83 1.3-2.57 1.7 1.35-2.13 1.7 1.35-2.13 1.59 1.33-1.88 1.59 1.33-1.88 1.64 1.45-1.86 1.64 1.45-1.86 1.38 1.15-1.67 0.000729 1.62 1.34-1.94 3.77e-07 2.17 1.82-2.59 5.37e-18 TRUE FALSE FALSE FALSE Female 1341 6444 GRCh37/hg19 P<=5e-09 2020-06-08 prsweb-phecode174-1-c3-breast-3-p-5e-09-mgi-20200608 prsweb-phecode174-1-c3-breast-3-p-5e-09-mgi-20200608 PRSWEB_PHECODE174.1_C3-BREAST-3_P_5e-09_MGI_20200608 P_5e-09 PRSWEB_PHECODE174.1_C3-BREAST-3_P_5e-09_MGI_20200608 174.1 Malignant neoplasm of breast Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-09) UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 21 3.3e-20 0.00760682 0.138 0.575 0.558-0.592 OR 2.38 1.54-3.69 2.38 1.54-3.69 2.5 1.83-3.42 2.5 1.83-3.42 1.7 1.35-2.14 1.7 1.35-2.14 1.56 1.31-1.86 1.56 1.31-1.86 1.57 1.38-1.78 1.57 1.38-1.78 1.39 1.15-1.68 0.000642 1.69 1.4-2.03 2.36e-08 2.12 1.78-2.53 8.49e-17 TRUE FALSE FALSE FALSE Female 1341 6444 GRCh37/hg19 P<=5e-09 2020-06-08 prsweb-phecode174-1-c50-p-5e-09-mgi-20200608 prsweb-phecode174-1-c50-p-5e-09-mgi-20200608 PRSWEB_PHECODE174.1_C50_P_5e-09_MGI_20200608 P_5e-09 PRSWEB_PHECODE174.1_C50_P_5e-09_MGI_20200608 174.1 Diagnoses - main ICD10: C50 Malignant neoplasm of breast Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-09) UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 14 1.9e-17 0.00711794 0.138 0.568 0.551-0.585 OR 1.98 1.25-3.13 1.98 1.25-3.13 1.83 1.3-2.58 1.83 1.3-2.58 1.65 1.31-2.08 1.65 1.31-2.08 1.55 1.3-1.84 1.55 1.3-1.84 1.49 1.31-1.69 1.49 1.31-1.69 1.28 1.06-1.55 0.00933 1.66 1.39-1.99 2.84e-08 1.94 1.63-2.32 1.18e-13 TRUE FALSE FALSE FALSE Female 1341 6444 GRCh37/hg19 P<=5e-09 2020-06-08 prsweb-phecode174-1-gwas-catalog-r2019-05-03-x174-1-p-5e-09-mgi-20200608 prsweb-phecode174-1-gwas-catalog-r2019-05-03-x174-1-p-5e-09-mgi-20200608 PRSWEB_PHECODE174.1_GWAS-Catalog-r2019-05-03-X174.1_P_5e-09_MGI_20200608 P_5e-09 PRSWEB_PHECODE174.1_GWAS-Catalog-r2019-05-03-X174.1_P_5e-09_MGI_20200608 174.1 Breast cancer;Breast cancer (estrogen-receptor negative);Breast Cancer in BRCA1 mutation carriers;Breast cancer in BRCA2 mutation carriers Binary 136 unique SNPs MGI Michigan Genomics Initiative Fixed threshold (5e-09) GWAS Catalog (2019-05-03) 17529967;17529973;17529974;18326623;19330027;19330030;20453838;20852631;20872241;21263130;21424380;23354978;23535729;23535733;23544012;23544013;25751625;29058716;29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=17529967+17529973+17529974+18326623+19330027+19330030+20453838+20852631+20872241+21263130+21424380+23354978+23535729+23535733+23544012+23544013+25751625+29058716+29059683 62 5.2e-37 0.0207597 0.136 0.607 0.589-0.623 OR 3.06 2.04-4.6 3.06 2.04-4.6 2.35 1.71-3.24 2.35 1.71-3.24 2.21 1.79-2.74 2.21 1.79-2.74 2.26 1.93-2.65 2.26 1.93-2.65 1.9 1.68-2.16 1.9 1.68-2.16 1.45 1.2-1.77 0.000182 1.75 1.45-2.12 9.46e-09 2.68 2.23-3.21 1.95e-26 TRUE FALSE FALSE FALSE Female 1341 6444 GRCh37/hg19 P<=5e-09 2020-06-08 prsweb-phecode174-1-onco-icogs-er-negative-brca-p-5e-09-mgi-20200608 prsweb-phecode174-1-onco-icogs-er-negative-brca-p-5e-09-mgi-20200608 PRSWEB_PHECODE174.1_Onco-iCOGS-ER-negative-BRCA_P_5e-09_MGI_20200608 P_5e-09 PRSWEB_PHECODE174.1_Onco-iCOGS-ER-negative-BRCA_P_5e-09_MGI_20200608 174.1 Breast cancer [female]; ER negative Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). MGI Michigan Genomics Initiative Fixed threshold (5e-09) Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 31 2.8e-13 0.00812061 0.139 0.561 0.544-0.578 OR 1.62 0.984-2.68 1.62 0.984-2.68 1.72 1.21-2.44 1.72 1.21-2.44 1.59 1.26-2.01 1.59 1.26-2.01 1.56 1.31-1.86 1.56 1.31-1.86 1.5 1.32-1.7 1.5 1.32-1.7 1.17 0.974-1.41 0.093 1.42 1.19-1.7 0.00011 1.8 1.51-2.13 2.36e-11 TRUE FALSE FALSE FALSE Female 1341 6444 GRCh37/hg19 P<=5e-09 2020-06-08 prsweb-phecode174-1-onco-icogs-er-positive-brca-p-5e-09-mgi-20200608 prsweb-phecode174-1-onco-icogs-er-positive-brca-p-5e-09-mgi-20200608 PRSWEB_PHECODE174.1_Onco-iCOGS-ER-positive-BRCA_P_5e-09_MGI_20200608 P_5e-09 PRSWEB_PHECODE174.1_Onco-iCOGS-ER-positive-BRCA_P_5e-09_MGI_20200608 174.1 Breast cancer [female]; ER positive Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). MGI Michigan Genomics Initiative Fixed threshold (5e-09) Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 210 2.6e-39 0.0267071 0.136 0.612 0.596-0.628 OR 2.82 1.86-4.27 2.82 1.86-4.27 2.15 1.55-2.99 2.15 1.55-2.99 2.5 2.03-3.07 2.5 2.03-3.07 2.1 1.78-2.47 2.1 1.78-2.47 1.88 1.66-2.13 1.88 1.66-2.13 1.38 1.13-1.69 0.00153 2.02 1.67-2.44 5.19e-13 2.74 2.28-3.29 2.61e-27 TRUE FALSE FALSE FALSE Female 1341 6444 GRCh37/hg19 P<=5e-09 2020-06-08 prsweb-phecode174-1-onco-icogs-overall-brca-p-5e-09-mgi-20200608 prsweb-phecode174-1-onco-icogs-overall-brca-p-5e-09-mgi-20200608 PRSWEB_PHECODE174.1_Onco-iCOGS-Overall-BRCA_P_5e-09_MGI_20200608 P_5e-09 PRSWEB_PHECODE174.1_Onco-iCOGS-Overall-BRCA_P_5e-09_MGI_20200608 174.1 Breast cancer [female], Overall Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). MGI Michigan Genomics Initiative Fixed threshold (5e-09) Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 264 1.7e-46 0.0357747 0.136 0.624 0.608-0.64 OR 2.56 1.68-3.9 2.56 1.68-3.9 2.92 2.17-3.93 2.92 2.17-3.93 2.39 1.95-2.95 2.39 1.95-2.95 2.19 1.86-2.57 2.19 1.86-2.57 2.01 1.78-2.28 2.01 1.78-2.28 1.76 1.43-2.17 1.02e-07 2.31 1.89-2.82 2.5e-16 3.37 2.78-4.08 4.68e-35 TRUE FALSE FALSE FALSE Female 1341 6444 GRCh37/hg19 P<=5e-09 2020-06-08 prsweb-phecode174-1-ukbb-saige-hrc-x174-1-p-5e-09-mgi-20200608 prsweb-phecode174-1-ukbb-saige-hrc-x174-1-p-5e-09-mgi-20200608 PRSWEB_PHECODE174.1_UKBB-SAIGE-HRC-X174.1_P_5e-09_MGI_20200608 P_5e-09 PRSWEB_PHECODE174.1_UKBB-SAIGE-HRC-X174.1_P_5e-09_MGI_20200608 174.1 Breast cancer [female] Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative Fixed threshold (5e-09) UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 24 4e-23 0.0091182 0.138 0.583 0.566-0.601 OR 2.37 1.53-3.67 2.37 1.53-3.67 1.9 1.36-2.67 1.9 1.36-2.67 1.69 1.34-2.13 1.69 1.34-2.13 1.61 1.35-1.91 1.61 1.35-1.91 1.67 1.47-1.9 1.67 1.47-1.9 1.42 1.17-1.73 0.000375 1.83 1.52-2.21 1.62e-10 2.37 1.98-2.84 5.44e-21 TRUE FALSE FALSE FALSE Female 1341 6444 GRCh37/hg19 P<=5e-09 2020-06-08 prsweb-phecode174-1-icogs-er-negative-brca-p-5e-09-mgi-20200608 prsweb-phecode174-1-icogs-er-negative-brca-p-5e-09-mgi-20200608 PRSWEB_PHECODE174.1_iCOGS-ER-negative-BRCA_P_5e-09_MGI_20200608 P_5e-09 PRSWEB_PHECODE174.1_iCOGS-ER-negative-BRCA_P_5e-09_MGI_20200608 174.1 Breast cancer [female]; ER negative Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). MGI Michigan Genomics Initiative Fixed threshold (5e-09) Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 8 8.4e-10 0.0055352 0.139 0.543 0.525-0.56 OR 1.74 1.08-2.81 1.74 1.08-2.81 1.66 1.17-2.36 1.66 1.17-2.36 1.5 1.18-1.9 1.5 1.18-1.9 1.51 1.27-1.8 1.51 1.27-1.8 1.34 1.18-1.53 1.34 1.18-1.53 1.37 1.14-1.63 0.000628 1.34 1.11-1.6 0.00171 1.66 1.39-1.97 1.1e-08 TRUE FALSE FALSE FALSE Female 1341 6444 GRCh37/hg19 P<=5e-09 2020-06-08 prsweb-phecode174-1-icogs-er-positive-brca-p-5e-09-mgi-20200608 prsweb-phecode174-1-icogs-er-positive-brca-p-5e-09-mgi-20200608 PRSWEB_PHECODE174.1_iCOGS-ER-positive-BRCA_P_5e-09_MGI_20200608 P_5e-09 PRSWEB_PHECODE174.1_iCOGS-ER-positive-BRCA_P_5e-09_MGI_20200608 174.1 Breast cancer [female]; ER positive Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). MGI Michigan Genomics Initiative Fixed threshold (5e-09) Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 63 2.4e-28 0.0168878 0.137 0.593 0.576-0.61 OR 2.13 1.36-3.34 2.13 1.36-3.34 1.93 1.38-2.7 1.93 1.38-2.7 2.04 1.64-2.54 2.04 1.64-2.54 1.87 1.58-2.21 1.87 1.58-2.21 1.78 1.57-2.01 1.78 1.57-2.01 1.44 1.19-1.75 0.000215 1.75 1.45-2.12 4.91e-09 2.47 2.06-2.96 4.78e-23 TRUE FALSE FALSE FALSE Female 1341 6444 GRCh37/hg19 P<=5e-09 2020-06-08 prsweb-phecode174-1-icogs-overall-brca-p-5e-09-mgi-20200608 prsweb-phecode174-1-icogs-overall-brca-p-5e-09-mgi-20200608 PRSWEB_PHECODE174.1_iCOGS-Overall-BRCA_P_5e-09_MGI_20200608 P_5e-09 PRSWEB_PHECODE174.1_iCOGS-Overall-BRCA_P_5e-09_MGI_20200608 174.1 Breast cancer [female], Overall Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). MGI Michigan Genomics Initiative Fixed threshold (5e-09) Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 77 1.4e-34 0.0211168 0.137 0.603 0.587-0.62 OR 2.33 1.51-3.6 2.33 1.51-3.6 2.26 1.64-3.11 2.26 1.64-3.11 2.2 1.78-2.72 2.2 1.78-2.72 1.87 1.58-2.2 1.87 1.58-2.2 1.79 1.58-2.03 1.79 1.58-2.03 1.6 1.31-1.96 4.25e-06 2.12 1.75-2.57 2.27e-14 2.78 2.31-3.35 3.68e-27 TRUE FALSE FALSE FALSE Female 1341 6444 GRCh37/hg19 P<=5e-09 2020-06-08 prsweb-phecode174-1-20001-1002-p-5e-08-mgi-20200608 prsweb-phecode174-1-20001-1002-p-5e-08-mgi-20200608 PRSWEB_PHECODE174.1_20001-1002_P_5e-08_MGI_20200608 P_5e-08 PRSWEB_PHECODE174.1_20001-1002_P_5e-08_MGI_20200608 174.1 Cancer code, self-reported: breast cancer Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative GWAS Hits UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 22 2.3e-22 0.00810679 0.138 0.579 0.561-0.597 OR 2.32 1.49-3.61 2.32 1.49-3.61 2.23 1.62-3.08 2.23 1.62-3.08 1.87 1.5-2.34 1.87 1.5-2.34 1.81 1.53-2.14 1.81 1.53-2.14 1.66 1.46-1.89 1.66 1.46-1.89 1.29 1.07-1.56 0.00877 1.59 1.32-1.91 6.65e-07 2.14 1.8-2.55 1.32e-17 TRUE FALSE FALSE TRUE Female 1341 6444 GRCh37/hg19 P<=5e-08 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000472/ScoringFiles/ phewas/PRSWEB_PHECODE174.1_20001-1002_P_5e-08_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE174.1_20001-1002_P_5e-08_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode174-1-c3-breast-3-p-5e-08-mgi-20200608 prsweb-phecode174-1-c3-breast-3-p-5e-08-mgi-20200608 PRSWEB_PHECODE174.1_C3-BREAST-3_P_5e-08_MGI_20200608 P_5e-08 PRSWEB_PHECODE174.1_C3-BREAST-3_P_5e-08_MGI_20200608 174.1 Malignant neoplasm of breast Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative GWAS Hits UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 32 2e-24 0.0103629 0.138 0.585 0.569-0.603 OR 1.97 1.24-3.14 1.97 1.24-3.14 2.19 1.59-3.02 2.19 1.59-3.02 1.75 1.39-2.19 1.75 1.39-2.19 1.55 1.3-1.85 1.55 1.3-1.85 1.62 1.42-1.84 1.62 1.42-1.84 1.4 1.15-1.69 0.000681 1.81 1.51-2.18 2.66e-10 2.24 1.88-2.68 5.94e-19 TRUE FALSE FALSE TRUE Female 1341 6444 GRCh37/hg19 P<=5e-08 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000476/ScoringFiles/ phewas/PRSWEB_PHECODE174.1_C3-BREAST-3_P_5e-08_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE174.1_C3-BREAST-3_P_5e-08_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode174-1-c50-p-5e-08-mgi-20200608 prsweb-phecode174-1-c50-p-5e-08-mgi-20200608 PRSWEB_PHECODE174.1_C50_P_5e-08_MGI_20200608 P_5e-08 PRSWEB_PHECODE174.1_C50_P_5e-08_MGI_20200608 174.1 Diagnoses - main ICD10: C50 Malignant neoplasm of breast Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative GWAS Hits UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 20 6.4e-21 0.00827899 0.138 0.576 0.559-0.593 OR 1.91 1.2-3.03 1.91 1.2-3.03 1.97 1.41-2.76 1.97 1.41-2.76 1.68 1.33-2.11 1.68 1.33-2.11 1.6 1.34-1.9 1.6 1.34-1.9 1.57 1.38-1.78 1.57 1.38-1.78 1.56 1.29-1.89 3.9e-06 1.78 1.47-2.14 1.68e-09 2.26 1.88-2.7 1.07e-18 TRUE FALSE FALSE TRUE Female 1341 6444 GRCh37/hg19 P<=5e-08 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000480/ScoringFiles/ phewas/PRSWEB_PHECODE174.1_C50_P_5e-08_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE174.1_C50_P_5e-08_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode174-1-gwas-catalog-r2019-05-03-x174-1-p-5e-08-mgi-20200608 prsweb-phecode174-1-gwas-catalog-r2019-05-03-x174-1-p-5e-08-mgi-20200608 PRSWEB_PHECODE174.1_GWAS-Catalog-r2019-05-03-X174.1_P_5e-08_MGI_20200608 P_5e-08 PRSWEB_PHECODE174.1_GWAS-Catalog-r2019-05-03-X174.1_P_5e-08_MGI_20200608 174.1 Breast cancer;Breast cancer (estrogen-receptor negative);Breast Cancer in BRCA1 mutation carriers;Breast cancer in BRCA2 mutation carriers Binary 136 unique SNPs MGI Michigan Genomics Initiative GWAS Hits GWAS Catalog (2019-05-03) 17529967;17529973;17529974;18326623;19330027;19330030;20453838;20852631;20872241;21263130;21424380;23354978;23535729;23535733;23544012;23544013;25751625;29058716;29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=17529967+17529973+17529974+18326623+19330027+19330030+20453838+20852631+20872241+21263130+21424380+23354978+23535729+23535733+23544012+23544013+25751625+29058716+29059683 62 5.2e-37 0.0207597 0.136 0.607 0.589-0.623 OR 3.06 2.04-4.6 3.06 2.04-4.6 2.35 1.71-3.24 2.35 1.71-3.24 2.21 1.79-2.74 2.21 1.79-2.74 2.26 1.93-2.65 2.26 1.93-2.65 1.9 1.68-2.16 1.9 1.68-2.16 1.45 1.2-1.77 0.000182 1.75 1.45-2.12 9.46e-09 2.68 2.23-3.21 1.95e-26 TRUE FALSE FALSE TRUE Female 1341 6444 GRCh37/hg19 P<=5e-08 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000485/ScoringFiles/ phewas/PRSWEB_PHECODE174.1_GWAS-Catalog-r2019-05-03-X174.1_P_5e-08_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE174.1_GWAS-Catalog-r2019-05-03-X174.1_P_5e-08_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode174-1-onco-icogs-er-negative-brca-p-5e-08-mgi-20200608 prsweb-phecode174-1-onco-icogs-er-negative-brca-p-5e-08-mgi-20200608 PRSWEB_PHECODE174.1_Onco-iCOGS-ER-negative-BRCA_P_5e-08_MGI_20200608 P_5e-08 PRSWEB_PHECODE174.1_Onco-iCOGS-ER-negative-BRCA_P_5e-08_MGI_20200608 174.1 Breast cancer [female]; ER negative Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). MGI Michigan Genomics Initiative GWAS Hits Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 49 1e-13 0.00998487 0.139 0.564 0.547-0.58 OR 1.72 1.05-2.81 1.72 1.05-2.81 1.86 1.32-2.63 1.86 1.32-2.63 1.54 1.22-1.95 1.54 1.22-1.95 1.47 1.23-1.75 1.47 1.23-1.75 1.42 1.24-1.61 1.42 1.24-1.61 1.24 1.03-1.5 0.0224 1.6 1.34-1.91 2.42e-07 1.81 1.52-2.15 3.15e-11 TRUE FALSE FALSE TRUE Female 1341 6444 GRCh37/hg19 P<=5e-08 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000489/ScoringFiles/ phewas/PRSWEB_PHECODE174.1_Onco-iCOGS-ER-negative-BRCA_P_5e-08_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE174.1_Onco-iCOGS-ER-negative-BRCA_P_5e-08_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode174-1-onco-icogs-er-positive-brca-p-5e-08-mgi-20200608 prsweb-phecode174-1-onco-icogs-er-positive-brca-p-5e-08-mgi-20200608 PRSWEB_PHECODE174.1_Onco-iCOGS-ER-positive-BRCA_P_5e-08_MGI_20200608 P_5e-08 PRSWEB_PHECODE174.1_Onco-iCOGS-ER-positive-BRCA_P_5e-08_MGI_20200608 174.1 Breast cancer [female]; ER positive Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). MGI Michigan Genomics Initiative GWAS Hits Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 257 2.8e-40 0.0284596 0.136 0.614 0.599-0.63 OR 2.35 1.51-3.66 2.35 1.51-3.66 2.38 1.73-3.26 2.38 1.73-3.26 2.19 1.77-2.71 2.19 1.77-2.71 2 1.69-2.35 2 1.69-2.35 1.85 1.63-2.1 1.85 1.63-2.1 1.27 1.04-1.55 0.0206 2.07 1.72-2.5 3.1e-14 2.65 2.21-3.18 5.02e-26 TRUE FALSE FALSE TRUE Female 1341 6444 GRCh37/hg19 P<=5e-08 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000497/ScoringFiles/ phewas/PRSWEB_PHECODE174.1_Onco-iCOGS-ER-positive-BRCA_P_5e-08_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE174.1_Onco-iCOGS-ER-positive-BRCA_P_5e-08_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode174-1-onco-icogs-overall-brca-p-5e-08-mgi-20200608 prsweb-phecode174-1-onco-icogs-overall-brca-p-5e-08-mgi-20200608 PRSWEB_PHECODE174.1_Onco-iCOGS-Overall-BRCA_P_5e-08_MGI_20200608 P_5e-08 PRSWEB_PHECODE174.1_Onco-iCOGS-Overall-BRCA_P_5e-08_MGI_20200608 174.1 Breast cancer [female], Overall Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). MGI Michigan Genomics Initiative GWAS Hits Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 334 1.6e-47 0.0371755 0.136 0.625 0.609-0.641 OR 3.32 2.24-4.93 3.32 2.24-4.93 2.73 2.02-3.69 2.73 2.02-3.69 2.51 2.04-3.08 2.51 2.04-3.08 2.19 1.86-2.57 2.19 1.86-2.57 2.01 1.78-2.28 2.01 1.78-2.28 1.79 1.45-2.22 6.09e-08 2.5 2.05-3.07 4.81e-19 3.52 2.9-4.28 1.47e-36 TRUE FALSE FALSE TRUE Female 1341 6444 GRCh37/hg19 P<=5e-08 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000505/ScoringFiles/ phewas/PRSWEB_PHECODE174.1_Onco-iCOGS-Overall-BRCA_P_5e-08_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE174.1_Onco-iCOGS-Overall-BRCA_P_5e-08_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode174-1-ukbb-saige-hrc-x174-1-p-5e-08-mgi-20200608 prsweb-phecode174-1-ukbb-saige-hrc-x174-1-p-5e-08-mgi-20200608 PRSWEB_PHECODE174.1_UKBB-SAIGE-HRC-X174.1_P_5e-08_MGI_20200608 P_5e-08 PRSWEB_PHECODE174.1_UKBB-SAIGE-HRC-X174.1_P_5e-08_MGI_20200608 174.1 Breast cancer [female] Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative GWAS Hits UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 41 3.6e-28 0.0127429 0.137 0.595 0.577-0.612 OR 1.8 1.12-2.91 1.8 1.12-2.91 1.87 1.33-2.63 1.87 1.33-2.63 1.77 1.41-2.22 1.77 1.41-2.22 1.77 1.5-2.1 1.77 1.5-2.1 1.79 1.58-2.03 1.79 1.58-2.03 1.33 1.09-1.61 0.00464 1.76 1.46-2.12 2.96e-09 2.43 2.03-2.91 1.61e-22 TRUE FALSE FALSE TRUE Female 1341 6444 GRCh37/hg19 P<=5e-08 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000513/ScoringFiles/ phewas/PRSWEB_PHECODE174.1_UKBB-SAIGE-HRC-X174.1_P_5e-08_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE174.1_UKBB-SAIGE-HRC-X174.1_P_5e-08_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode174-1-icogs-er-negative-brca-p-5e-08-mgi-20200608 prsweb-phecode174-1-icogs-er-negative-brca-p-5e-08-mgi-20200608 PRSWEB_PHECODE174.1_iCOGS-ER-negative-BRCA_P_5e-08_MGI_20200608 P_5e-08 PRSWEB_PHECODE174.1_iCOGS-ER-negative-BRCA_P_5e-08_MGI_20200608 174.1 Breast cancer [female]; ER negative Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). MGI Michigan Genomics Initiative GWAS Hits Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 10 1.6e-11 0.00720804 0.139 0.55 0.533-0.566 OR 1.88 1.17-3.03 1.88 1.17-3.03 1.63 1.14-2.34 1.63 1.14-2.34 1.54 1.21-1.95 1.54 1.21-1.95 1.44 1.21-1.72 1.44 1.21-1.72 1.37 1.2-1.56 1.37 1.2-1.56 1.44 1.2-1.72 8.97e-05 1.41 1.17-1.69 0.000242 1.77 1.48-2.11 2.4e-10 TRUE FALSE FALSE TRUE Female 1341 6444 GRCh37/hg19 P<=5e-08 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000517/ScoringFiles/ phewas/PRSWEB_PHECODE174.1_iCOGS-ER-negative-BRCA_P_5e-08_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE174.1_iCOGS-ER-negative-BRCA_P_5e-08_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode174-1-icogs-er-positive-brca-p-5e-08-mgi-20200608 prsweb-phecode174-1-icogs-er-positive-brca-p-5e-08-mgi-20200608 PRSWEB_PHECODE174.1_iCOGS-ER-positive-BRCA_P_5e-08_MGI_20200608 P_5e-08 PRSWEB_PHECODE174.1_iCOGS-ER-positive-BRCA_P_5e-08_MGI_20200608 174.1 Breast cancer [female]; ER positive Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). MGI Michigan Genomics Initiative GWAS Hits Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 86 1.2e-30 0.0196761 0.137 0.597 0.58-0.614 OR 2.28 1.46-3.56 2.28 1.46-3.56 2.25 1.64-3.11 2.25 1.64-3.11 1.88 1.51-2.35 1.88 1.51-2.35 2.01 1.71-2.37 2.01 1.71-2.37 1.73 1.52-1.96 1.73 1.52-1.96 1.42 1.17-1.73 0.000481 1.93 1.6-2.33 5.9e-12 2.49 2.08-2.99 4.41e-23 TRUE FALSE FALSE TRUE Female 1341 6444 GRCh37/hg19 P<=5e-08 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000525/ScoringFiles/ phewas/PRSWEB_PHECODE174.1_iCOGS-ER-positive-BRCA_P_5e-08_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE174.1_iCOGS-ER-positive-BRCA_P_5e-08_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode174-1-icogs-overall-brca-p-5e-08-mgi-20200608 prsweb-phecode174-1-icogs-overall-brca-p-5e-08-mgi-20200608 PRSWEB_PHECODE174.1_iCOGS-Overall-BRCA_P_5e-08_MGI_20200608 P_5e-08 PRSWEB_PHECODE174.1_iCOGS-Overall-BRCA_P_5e-08_MGI_20200608 174.1 Breast cancer [female], Overall Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). MGI Michigan Genomics Initiative GWAS Hits Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 110 2.8e-37 0.021414 0.137 0.607 0.591-0.623 OR 2.51 1.63-3.86 2.51 1.63-3.86 2.56 1.88-3.48 2.56 1.88-3.48 2.35 1.91-2.89 2.35 1.91-2.89 1.97 1.67-2.32 1.97 1.67-2.32 1.88 1.66-2.13 1.88 1.66-2.13 1.5 1.23-1.83 6.86e-05 1.9 1.57-2.3 4.31e-11 2.74 2.28-3.29 2.97e-27 TRUE FALSE FALSE TRUE Female 1341 6444 GRCh37/hg19 P<=5e-08 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000533/ScoringFiles/ phewas/PRSWEB_PHECODE174.1_iCOGS-Overall-BRCA_P_5e-08_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE174.1_iCOGS-Overall-BRCA_P_5e-08_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode174-1-20001-1002-pt-mgi-20200608 prsweb-phecode174-1-20001-1002-pt-mgi-20200608 PRSWEB_PHECODE174.1_20001-1002_PT_MGI_20200608 P&T PRSWEB_PHECODE174.1_20001-1002_PT_MGI_20200608 174.1 Cancer code, self-reported: breast cancer Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative P&T UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 68 3.2e-21 0.012988 0.138 0.58 0.563-0.597 OR 1.54 0.924-2.56 1.54 0.924-2.56 1.77 1.25-2.5 1.77 1.25-2.5 1.72 1.37-2.17 1.72 1.37-2.17 1.73 1.46-2.06 1.73 1.46-2.06 1.69 1.49-1.92 1.69 1.49-1.92 1.34 1.11-1.61 0.00244 1.51 1.26-1.82 1.04e-05 2.16 1.82-2.58 5.1e-18 TRUE FALSE FALSE TRUE Female 1341 6444 GRCh37/hg19 P<=6.31e-06 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000474/ScoringFiles/ phewas/PRSWEB_PHECODE174.1_20001-1002_PT_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE174.1_20001-1002_PT_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode174-1-c3-breast-3-pt-mgi-20200608 prsweb-phecode174-1-c3-breast-3-pt-mgi-20200608 PRSWEB_PHECODE174.1_C3-BREAST-3_PT_MGI_20200608 P&T PRSWEB_PHECODE174.1_C3-BREAST-3_PT_MGI_20200608 174.1 Malignant neoplasm of breast Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative P&T UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 120 1.1e-28 0.014399 0.137 0.595 0.578-0.611 OR 2.31 1.47-3.61 2.31 1.47-3.61 2.08 1.5-2.89 2.08 1.5-2.89 1.83 1.46-2.29 1.83 1.46-2.29 1.83 1.54-2.16 1.83 1.54-2.16 1.76 1.55-2 1.76 1.55-2 1.37 1.13-1.66 0.00147 1.68 1.4-2.02 3.39e-08 2.37 1.99-2.83 1.5e-21 TRUE FALSE FALSE TRUE Female 1341 6444 GRCh37/hg19 P<=1.26e-05 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000478/ScoringFiles/ phewas/PRSWEB_PHECODE174.1_C3-BREAST-3_PT_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE174.1_C3-BREAST-3_PT_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode174-1-c50-pt-mgi-20200608 prsweb-phecode174-1-c50-pt-mgi-20200608 PRSWEB_PHECODE174.1_C50_PT_MGI_20200608 P&T PRSWEB_PHECODE174.1_C50_PT_MGI_20200608 174.1 Diagnoses - main ICD10: C50 Malignant neoplasm of breast Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative P&T UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 42 1.5e-23 0.0126612 0.138 0.584 0.568-0.601 OR 1.43 0.853-2.41 1.43 0.853-2.41 1.85 1.32-2.61 1.85 1.32-2.61 1.72 1.37-2.16 1.72 1.37-2.16 1.69 1.43-2.01 1.69 1.43-2.01 1.69 1.49-1.92 1.69 1.49-1.92 1.19 0.982-1.44 0.0757 1.58 1.32-1.9 5.95e-07 2.12 1.78-2.52 2.34e-17 TRUE FALSE FALSE TRUE Female 1341 6444 GRCh37/hg19 P<=1.58e-06 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000482/ScoringFiles/ phewas/PRSWEB_PHECODE174.1_C50_PT_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE174.1_C50_PT_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode174-1-d05-pt-mgi-20200608 prsweb-phecode174-1-d05-pt-mgi-20200608 PRSWEB_PHECODE174.1_D05_PT_MGI_20200608 P&T PRSWEB_PHECODE174.1_D05_PT_MGI_20200608 174.1 Diagnoses - main ICD10: D05 Carcinoma in situ of breast Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative P&T UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 25 0.00014 0.00212228 0.139 0.52 0.504-0.538 OR 1.39 0.817-2.36 1.39 0.817-2.36 1.26 0.85-1.86 1.26 0.85-1.86 1.12 0.862-1.45 1.12 0.862-1.45 1.3 1.08-1.56 1.3 1.08-1.56 1.2 1.05-1.37 1.2 1.05-1.37 1.06 0.891-1.26 0.506 1.21 1.02-1.43 0.0323 1.3 1.1-1.54 0.00217 TRUE FALSE FALSE TRUE Female 1341 6444 GRCh37/hg19 P<=7.94e-06 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000484/ScoringFiles/ phewas/PRSWEB_PHECODE174.1_D05_PT_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE174.1_D05_PT_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode174-1-gwas-catalog-r2019-05-03-x174-1-pt-mgi-20200608 prsweb-phecode174-1-gwas-catalog-r2019-05-03-x174-1-pt-mgi-20200608 PRSWEB_PHECODE174.1_GWAS-Catalog-r2019-05-03-X174.1_PT_MGI_20200608 P&T PRSWEB_PHECODE174.1_GWAS-Catalog-r2019-05-03-X174.1_PT_MGI_20200608 174.1 Breast cancer;Breast cancer (estrogen-receptor negative);Breast Cancer in BRCA1 mutation carriers;Breast cancer in BRCA2 mutation carriers Binary 136 unique SNPs MGI Michigan Genomics Initiative P&T GWAS Catalog (2019-05-03) 17529967;17529973;17529974;18326623;19330027;19330030;20453838;20852631;20872241;21263130;21424380;23354978;23535729;23535733;23544012;23544013;25751625;29058716;29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=17529967+17529973+17529974+18326623+19330027+19330030+20453838+20852631+20872241+21263130+21424380+23354978+23535729+23535733+23544012+23544013+25751625+29058716+29059683 62 5.2e-37 0.0207597 0.136 0.607 0.589-0.623 OR 3.06 2.04-4.6 3.06 2.04-4.6 2.35 1.71-3.24 2.35 1.71-3.24 2.21 1.79-2.74 2.21 1.79-2.74 2.26 1.93-2.65 2.26 1.93-2.65 1.9 1.68-2.16 1.9 1.68-2.16 1.45 1.2-1.77 0.000182 1.75 1.45-2.12 9.46e-09 2.68 2.23-3.21 1.95e-26 TRUE FALSE FALSE TRUE Female 1341 6444 GRCh37/hg19 P<=3.16e-09 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000487/ScoringFiles/ phewas/PRSWEB_PHECODE174.1_GWAS-Catalog-r2019-05-03-X174.1_PT_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE174.1_GWAS-Catalog-r2019-05-03-X174.1_PT_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode174-1-onco-icogs-er-negative-brca-pt-mgi-20200608 prsweb-phecode174-1-onco-icogs-er-negative-brca-pt-mgi-20200608 PRSWEB_PHECODE174.1_Onco-iCOGS-ER-negative-BRCA_PT_MGI_20200608 P&T PRSWEB_PHECODE174.1_Onco-iCOGS-ER-negative-BRCA_PT_MGI_20200608 174.1 Breast cancer [female]; ER negative Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). MGI Michigan Genomics Initiative P&T Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 217 1e-18 0.0104166 0.138 0.576 0.559-0.593 OR 1.84 1.14-2.97 1.84 1.14-2.97 1.77 1.26-2.49 1.77 1.26-2.49 1.79 1.43-2.24 1.79 1.43-2.24 1.56 1.31-1.85 1.56 1.31-1.85 1.58 1.39-1.8 1.58 1.39-1.8 1.36 1.13-1.64 0.00107 1.5 1.25-1.8 1.5e-05 2.03 1.7-2.43 3.19e-15 TRUE FALSE FALSE TRUE Female 1341 6444 GRCh37/hg19 P<=1.58e-05 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000493/ScoringFiles/ phewas/PRSWEB_PHECODE174.1_Onco-iCOGS-ER-negative-BRCA_PT_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE174.1_Onco-iCOGS-ER-negative-BRCA_PT_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode174-1-onco-icogs-er-positive-brca-pt-mgi-20200608 prsweb-phecode174-1-onco-icogs-er-positive-brca-pt-mgi-20200608 PRSWEB_PHECODE174.1_Onco-iCOGS-ER-positive-BRCA_PT_MGI_20200608 P&T PRSWEB_PHECODE174.1_Onco-iCOGS-ER-positive-BRCA_PT_MGI_20200608 174.1 Breast cancer [female]; ER positive Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). MGI Michigan Genomics Initiative P&T Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 1142 8.1e-45 0.0356047 0.136 0.621 0.605-0.638 OR 2.7 1.77-4.1 2.7 1.77-4.1 2.84 2.11-3.84 2.84 2.11-3.84 2.34 1.9-2.89 2.34 1.9-2.89 2.23 1.9-2.62 2.23 1.9-2.62 2.1 1.85-2.38 2.1 1.85-2.38 1.41 1.15-1.72 0.000941 1.84 1.52-2.23 5.24e-10 2.93 2.44-3.52 4.4e-31 TRUE FALSE FALSE TRUE Female 1341 6444 GRCh37/hg19 P<=7.94e-05 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000501/ScoringFiles/ phewas/PRSWEB_PHECODE174.1_Onco-iCOGS-ER-positive-BRCA_PT_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE174.1_Onco-iCOGS-ER-positive-BRCA_PT_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode174-1-onco-icogs-overall-brca-pt-mgi-20200608 prsweb-phecode174-1-onco-icogs-overall-brca-pt-mgi-20200608 PRSWEB_PHECODE174.1_Onco-iCOGS-Overall-BRCA_PT_MGI_20200608 P&T PRSWEB_PHECODE174.1_Onco-iCOGS-Overall-BRCA_PT_MGI_20200608 174.1 Breast cancer [female], Overall Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). MGI Michigan Genomics Initiative P&T Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 3038 2.2e-53 0.0410376 0.135 0.635 0.618-0.651 OR 2.84 1.88-4.28 2.84 1.88-4.28 2.69 1.99-3.65 2.69 1.99-3.65 2.63 2.15-3.23 2.63 2.15-3.23 2.58 2.2-3.01 2.58 2.2-3.01 2.24 1.98-2.54 2.24 1.98-2.54 1.24 1-1.52 0.045 2 1.65-2.43 1.99e-12 3.15 2.62-3.78 3.88e-34 TRUE FALSE FALSE TRUE Female 1341 6444 GRCh37/hg19 P<=0.000398 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000509/ScoringFiles/ phewas/PRSWEB_PHECODE174.1_Onco-iCOGS-Overall-BRCA_PT_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE174.1_Onco-iCOGS-Overall-BRCA_PT_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode174-1-ukbb-saige-hrc-x174-1-pt-mgi-20200608 prsweb-phecode174-1-ukbb-saige-hrc-x174-1-pt-mgi-20200608 PRSWEB_PHECODE174.1_UKBB-SAIGE-HRC-X174.1_PT_MGI_20200608 P&T PRSWEB_PHECODE174.1_UKBB-SAIGE-HRC-X174.1_PT_MGI_20200608 174.1 Breast cancer [female] Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative P&T UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 84 2.8e-33 0.0182677 0.137 0.605 0.588-0.621 OR 2.09 1.31-3.32 2.09 1.31-3.32 2.33 1.7-3.21 2.33 1.7-3.21 1.75 1.4-2.2 1.75 1.4-2.2 1.74 1.47-2.06 1.74 1.47-2.06 1.93 1.7-2.19 1.93 1.7-2.19 1.49 1.22-1.82 0.000111 1.97 1.63-2.39 4.09e-12 2.85 2.37-3.43 5.12e-29 TRUE FALSE FALSE TRUE Female 1341 6444 GRCh37/hg19 P<=1.58e-06 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000515/ScoringFiles/ phewas/PRSWEB_PHECODE174.1_UKBB-SAIGE-HRC-X174.1_PT_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE174.1_UKBB-SAIGE-HRC-X174.1_PT_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode174-1-icogs-er-negative-brca-pt-mgi-20200608 prsweb-phecode174-1-icogs-er-negative-brca-pt-mgi-20200608 PRSWEB_PHECODE174.1_iCOGS-ER-negative-BRCA_PT_MGI_20200608 P&T PRSWEB_PHECODE174.1_iCOGS-ER-negative-BRCA_PT_MGI_20200608 174.1 Breast cancer [female]; ER negative Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). MGI Michigan Genomics Initiative P&T Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 9 6.5e-11 0.00741743 0.139 0.548 0.53-0.564 OR 1.88 1.18-2.99 1.88 1.18-2.99 1.76 1.25-2.49 1.76 1.25-2.49 1.5 1.18-1.9 1.5 1.18-1.9 1.6 1.35-1.9 1.6 1.35-1.9 1.31 1.15-1.5 1.31 1.15-1.5 1.44 1.2-1.72 7.32e-05 1.4 1.17-1.68 0.000253 1.68 1.41-2 5.91e-09 TRUE FALSE FALSE TRUE Female 1341 6444 GRCh37/hg19 P<=7.94e-09 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000521/ScoringFiles/ phewas/PRSWEB_PHECODE174.1_iCOGS-ER-negative-BRCA_PT_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE174.1_iCOGS-ER-negative-BRCA_PT_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode174-1-icogs-er-positive-brca-pt-mgi-20200608 prsweb-phecode174-1-icogs-er-positive-brca-pt-mgi-20200608 PRSWEB_PHECODE174.1_iCOGS-ER-positive-BRCA_PT_MGI_20200608 P&T PRSWEB_PHECODE174.1_iCOGS-ER-positive-BRCA_PT_MGI_20200608 174.1 Breast cancer [female]; ER positive Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). MGI Michigan Genomics Initiative P&T Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 310 1.2e-30 0.0240026 0.137 0.597 0.58-0.612 OR 2.98 1.98-4.47 2.98 1.98-4.47 2.46 1.81-3.35 2.46 1.81-3.35 2.38 1.93-2.93 2.38 1.93-2.93 1.99 1.69-2.35 1.99 1.69-2.35 1.77 1.56-2.01 1.77 1.56-2.01 1.4 1.16-1.7 0.00063 1.81 1.5-2.18 5.63e-10 2.47 2.06-2.95 5.58e-23 TRUE FALSE FALSE TRUE Female 1341 6444 GRCh37/hg19 P<=2.51e-05 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000529/ScoringFiles/ phewas/PRSWEB_PHECODE174.1_iCOGS-ER-positive-BRCA_PT_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE174.1_iCOGS-ER-positive-BRCA_PT_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode174-1-icogs-overall-brca-pt-mgi-20200608 prsweb-phecode174-1-icogs-overall-brca-pt-mgi-20200608 PRSWEB_PHECODE174.1_iCOGS-Overall-BRCA_PT_MGI_20200608 P&T PRSWEB_PHECODE174.1_iCOGS-Overall-BRCA_PT_MGI_20200608 174.1 Breast cancer [female], Overall Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). MGI Michigan Genomics Initiative P&T Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 363 8e-38 0.0258032 0.136 0.609 0.592-0.626 OR 3.44 2.31-5.13 3.44 2.31-5.13 2.53 1.85-3.45 2.53 1.85-3.45 2.04 1.64-2.54 2.04 1.64-2.54 1.99 1.69-2.35 1.99 1.69-2.35 1.91 1.68-2.16 1.91 1.68-2.16 1.28 1.05-1.56 0.0161 1.89 1.57-2.29 2.86e-11 2.65 2.21-3.17 2.92e-26 TRUE FALSE FALSE TRUE Female 1341 6444 GRCh37/hg19 P<=2e-05 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000537/ScoringFiles/ phewas/PRSWEB_PHECODE174.1_iCOGS-Overall-BRCA_PT_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE174.1_iCOGS-Overall-BRCA_PT_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode174-1-20001-1002-prs-cs-mgi-20200608 prsweb-phecode174-1-20001-1002-prs-cs-mgi-20200608 PRSWEB_PHECODE174.1_20001-1002_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE174.1_20001-1002_PRS-CS_MGI_20200608 174.1 Cancer code, self-reported: breast cancer Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative PRS-CS UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1111495 1.3e-18 0.0138568 0.138 0.576 0.56-0.592 OR 1.6 0.981-2.62 1.6 0.981-2.62 1.86 1.32-2.63 1.86 1.32-2.63 1.77 1.41-2.22 1.77 1.41-2.22 1.71 1.45-2.03 1.71 1.45-2.03 1.55 1.36-1.76 1.55 1.36-1.76 1.22 1.01-1.48 0.0345 1.54 1.29-1.85 2.14e-06 1.94 1.63-2.31 6.21e-14 TRUE FALSE FALSE TRUE Female 1341 6444 GRCh37/hg19 auto https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000473/ScoringFiles/ phewas/PRSWEB_PHECODE174.1_20001-1002_PRS-CS_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE174.1_20001-1002_PRS-CS_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode174-1-c3-breast-3-prs-cs-mgi-20200608 prsweb-phecode174-1-c3-breast-3-prs-cs-mgi-20200608 PRSWEB_PHECODE174.1_C3-BREAST-3_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE174.1_C3-BREAST-3_PRS-CS_MGI_20200608 174.1 Malignant neoplasm of breast Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative PRS-CS UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1111495 3.7e-21 0.0176437 0.138 0.581 0.564-0.597 OR 2.17 1.38-3.41 2.17 1.38-3.41 2.23 1.62-3.07 2.23 1.62-3.07 1.89 1.52-2.35 1.89 1.52-2.35 1.76 1.49-2.08 1.76 1.49-2.08 1.54 1.36-1.75 1.54 1.36-1.75 1.57 1.3-1.89 2.75e-06 1.67 1.38-2.01 6.92e-08 2.19 1.83-2.62 9.38e-18 TRUE FALSE FALSE TRUE Female 1341 6444 GRCh37/hg19 auto https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000477/ScoringFiles/ phewas/PRSWEB_PHECODE174.1_C3-BREAST-3_PRS-CS_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE174.1_C3-BREAST-3_PRS-CS_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode174-1-c50-prs-cs-mgi-20200608 prsweb-phecode174-1-c50-prs-cs-mgi-20200608 PRSWEB_PHECODE174.1_C50_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE174.1_C50_PRS-CS_MGI_20200608 174.1 Diagnoses - main ICD10: C50 Malignant neoplasm of breast Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative PRS-CS UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1111495 7.1e-20 0.0136922 0.138 0.578 0.56-0.596 OR 2.03 1.29-3.2 2.03 1.29-3.2 2.12 1.53-2.92 2.12 1.53-2.92 1.92 1.54-2.4 1.92 1.54-2.4 1.73 1.47-2.05 1.73 1.47-2.05 1.5 1.32-1.7 1.5 1.32-1.7 1.43 1.18-1.73 0.000227 1.8 1.5-2.16 3.58e-10 2.12 1.77-2.53 2.15e-16 TRUE FALSE FALSE TRUE Female 1341 6444 GRCh37/hg19 auto https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000481/ScoringFiles/ phewas/PRSWEB_PHECODE174.1_C50_PRS-CS_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE174.1_C50_PRS-CS_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode174-1-d05-prs-cs-mgi-20200608 prsweb-phecode174-1-d05-prs-cs-mgi-20200608 PRSWEB_PHECODE174.1_D05_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE174.1_D05_PRS-CS_MGI_20200608 174.1 Diagnoses - main ICD10: D05 Carcinoma in situ of breast Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative PRS-CS UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1107790 0.073 0.00164358 0.14 0.519 0.503-0.536 OR 1.16 0.667-2.02 1.16 0.667-2.02 1.25 0.853-1.84 1.25 0.853-1.84 1.18 0.912-1.51 1.18 0.912-1.51 1.06 0.871-1.28 1.06 0.871-1.28 1.19 1.04-1.36 1.19 1.04-1.36 0.887 0.745-1.06 0.176 1.04 0.878-1.23 0.652 1.16 0.984-1.37 0.0781 FALSE FALSE FALSE FALSE Female 1341 6444 GRCh37/hg19 auto 2020-06-08 prsweb-phecode174-1-onco-icogs-er-negative-brca-prs-cs-mgi-20200608 prsweb-phecode174-1-onco-icogs-er-negative-brca-prs-cs-mgi-20200608 PRSWEB_PHECODE174.1_Onco-iCOGS-ER-negative-BRCA_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE174.1_Onco-iCOGS-ER-negative-BRCA_PRS-CS_MGI_20200608 174.1 Breast cancer [female]; ER negative Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). MGI Michigan Genomics Initiative PRS-CS Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 1119140 5e-19 0.0139296 0.138 0.578 0.56-0.594 OR 1.8 1.13-2.88 1.8 1.13-2.88 1.75 1.24-2.48 1.75 1.24-2.48 1.68 1.33-2.11 1.68 1.33-2.11 1.66 1.39-1.97 1.66 1.39-1.97 1.54 1.35-1.76 1.54 1.35-1.76 1.11 0.917-1.33 0.291 1.51 1.27-1.81 5.1e-06 1.8 1.51-2.15 5.43e-11 TRUE FALSE FALSE TRUE Female 1341 6444 GRCh37/hg19 auto https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000491/ScoringFiles/ phewas/PRSWEB_PHECODE174.1_Onco-iCOGS-ER-negative-BRCA_PRS-CS_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE174.1_Onco-iCOGS-ER-negative-BRCA_PRS-CS_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode174-1-onco-icogs-er-positive-brca-prs-cs-mgi-20200608 prsweb-phecode174-1-onco-icogs-er-positive-brca-prs-cs-mgi-20200608 PRSWEB_PHECODE174.1_Onco-iCOGS-ER-positive-BRCA_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE174.1_Onco-iCOGS-ER-positive-BRCA_PRS-CS_MGI_20200608 174.1 Breast cancer [female]; ER positive Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). MGI Michigan Genomics Initiative PRS-CS Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 1119140 4.7e-59 0.044483 0.134 0.643 0.627-0.658 OR 3.71 2.52-5.47 3.71 2.52-5.47 3.22 2.41-4.31 3.22 2.41-4.31 2.81 2.3-3.45 2.81 2.3-3.45 2.71 2.32-3.17 2.71 2.32-3.17 2.36 2.08-2.68 2.36 2.08-2.68 1.4 1.14-1.72 0.00143 1.99 1.63-2.42 1.02e-11 3.38 2.81-4.07 1.41e-37 TRUE FALSE FALSE TRUE Female 1341 6444 GRCh37/hg19 auto https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000499/ScoringFiles/ phewas/PRSWEB_PHECODE174.1_Onco-iCOGS-ER-positive-BRCA_PRS-CS_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE174.1_Onco-iCOGS-ER-positive-BRCA_PRS-CS_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode174-1-onco-icogs-overall-brca-prs-cs-mgi-20200608 prsweb-phecode174-1-onco-icogs-overall-brca-prs-cs-mgi-20200608 PRSWEB_PHECODE174.1_Onco-iCOGS-Overall-BRCA_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE174.1_Onco-iCOGS-Overall-BRCA_PRS-CS_MGI_20200608 174.1 Breast cancer [female], Overall Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). MGI Michigan Genomics Initiative PRS-CS Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 1119140 1e-65 0.0523367 0.133 0.651 0.635-0.666 OR 3.22 2.15-4.81 3.22 2.15-4.81 3.62 2.72-4.81 3.62 2.72-4.81 3.06 2.5-3.74 3.06 2.5-3.74 2.79 2.39-3.27 2.79 2.39-3.27 2.55 2.25-2.89 2.55 2.25-2.89 1.44 1.17-1.77 0.000634 1.91 1.57-2.33 1.79e-10 3.61 2.99-4.35 5.43e-41 TRUE FALSE FALSE TRUE Female 1341 6444 GRCh37/hg19 auto https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000507/ScoringFiles/ phewas/PRSWEB_PHECODE174.1_Onco-iCOGS-Overall-BRCA_PRS-CS_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE174.1_Onco-iCOGS-Overall-BRCA_PRS-CS_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode174-1-ukbb-saige-hrc-x174-1-prs-cs-mgi-20200608 prsweb-phecode174-1-ukbb-saige-hrc-x174-1-prs-cs-mgi-20200608 PRSWEB_PHECODE174.1_UKBB-SAIGE-HRC-X174.1_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE174.1_UKBB-SAIGE-HRC-X174.1_PRS-CS_MGI_20200608 174.1 Breast cancer [female] Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative PRS-CS UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1119237 2.1e-26 0.0189124 0.137 0.59 0.573-0.607 OR 1.79 1.12-2.86 1.79 1.12-2.86 2.41 1.77-3.3 2.41 1.77-3.3 2.13 1.72-2.64 2.13 1.72-2.64 1.94 1.64-2.28 1.94 1.64-2.28 1.86 1.64-2.11 1.86 1.64-2.11 1.26 1.04-1.52 0.016 1.39 1.15-1.67 0.000588 2.25 1.89-2.67 4.05e-20 TRUE FALSE FALSE TRUE Female 1341 6444 GRCh37/hg19 auto https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000514/ScoringFiles/ phewas/PRSWEB_PHECODE174.1_UKBB-SAIGE-HRC-X174.1_PRS-CS_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE174.1_UKBB-SAIGE-HRC-X174.1_PRS-CS_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode174-1-icogs-er-negative-brca-prs-cs-mgi-20200608 prsweb-phecode174-1-icogs-er-negative-brca-prs-cs-mgi-20200608 PRSWEB_PHECODE174.1_iCOGS-ER-negative-BRCA_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE174.1_iCOGS-ER-negative-BRCA_PRS-CS_MGI_20200608 174.1 Breast cancer [female]; ER negative Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). MGI Michigan Genomics Initiative PRS-CS Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 1115376 4.2e-06 0.0021514 0.139 0.539 0.52-0.556 OR 1.51 0.907-2.51 1.51 0.907-2.51 1.39 0.952-2.02 1.39 0.952-2.02 1.51 1.19-1.92 1.51 1.19-1.92 1.36 1.14-1.63 1.36 1.14-1.63 1.32 1.16-1.5 1.32 1.16-1.5 1.04 0.874-1.25 0.64 1.16 0.972-1.37 0.101 1.4 1.18-1.65 8.92e-05 TRUE FALSE FALSE TRUE Female 1341 6444 GRCh37/hg19 auto https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000519/ScoringFiles/ phewas/PRSWEB_PHECODE174.1_iCOGS-ER-negative-BRCA_PRS-CS_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE174.1_iCOGS-ER-negative-BRCA_PRS-CS_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode174-1-icogs-er-positive-brca-prs-cs-mgi-20200608 prsweb-phecode174-1-icogs-er-positive-brca-prs-cs-mgi-20200608 PRSWEB_PHECODE174.1_iCOGS-ER-positive-BRCA_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE174.1_iCOGS-ER-positive-BRCA_PRS-CS_MGI_20200608 174.1 Breast cancer [female]; ER positive Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). MGI Michigan Genomics Initiative PRS-CS Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 1115436 4.2e-39 0.0285053 0.136 0.613 0.595-0.63 OR 3.75 2.55-5.51 3.75 2.55-5.51 3.19 2.39-4.26 3.19 2.39-4.26 2.51 2.04-3.08 2.51 2.04-3.08 2.25 1.92-2.64 2.25 1.92-2.64 2.04 1.8-2.31 2.04 1.8-2.31 1.2 0.982-1.46 0.0755 1.67 1.39-2.02 8.09e-08 2.63 2.2-3.14 8.17e-27 TRUE FALSE FALSE TRUE Female 1341 6444 GRCh37/hg19 auto https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000527/ScoringFiles/ phewas/PRSWEB_PHECODE174.1_iCOGS-ER-positive-BRCA_PRS-CS_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE174.1_iCOGS-ER-positive-BRCA_PRS-CS_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode174-1-icogs-overall-brca-prs-cs-mgi-20200608 prsweb-phecode174-1-icogs-overall-brca-prs-cs-mgi-20200608 PRSWEB_PHECODE174.1_iCOGS-Overall-BRCA_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE174.1_iCOGS-Overall-BRCA_PRS-CS_MGI_20200608 174.1 Breast cancer [female], Overall Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). MGI Michigan Genomics Initiative PRS-CS Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 1115484 1.3e-45 0.0294967 0.135 0.622 0.605-0.638 OR 3.43 2.32-5.05 3.43 2.32-5.05 2.95 2.2-3.96 2.95 2.2-3.96 2.51 2.05-3.09 2.51 2.05-3.09 2.34 1.99-2.74 2.34 1.99-2.74 2.14 1.89-2.42 2.14 1.89-2.42 1.33 1.09-1.63 0.00609 1.9 1.57-2.31 4.88e-11 3.01 2.51-3.61 2.05e-32 TRUE FALSE FALSE TRUE Female 1341 6444 GRCh37/hg19 auto https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000535/ScoringFiles/ phewas/PRSWEB_PHECODE174.1_iCOGS-Overall-BRCA_PRS-CS_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE174.1_iCOGS-Overall-BRCA_PRS-CS_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode174-1-20001-1002-lassosum-mgi-20200608 prsweb-phecode174-1-20001-1002-lassosum-mgi-20200608 PRSWEB_PHECODE174.1_20001-1002_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE174.1_20001-1002_LASSOSUM_MGI_20200608 174.1 Cancer code, self-reported: breast cancer Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative lassosum UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 30041 7.8e-22 0.0208462 0.138 0.586 0.57-0.603 OR 1.59 0.962-2.62 1.59 0.962-2.62 1.46 1.01-2.1 1.46 1.01-2.1 1.66 1.32-2.09 1.66 1.32-2.09 1.73 1.46-2.05 1.73 1.46-2.05 1.75 1.54-1.98 1.75 1.54-1.98 1.26 1.05-1.52 0.0156 1.51 1.25-1.81 1.16e-05 2.19 1.84-2.61 8.59e-19 TRUE FALSE FALSE TRUE Female 1341 6444 GRCh37/hg19 s=0.5;Lambda=0.01438 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000475/ScoringFiles/ phewas/PRSWEB_PHECODE174.1_20001-1002_LASSOSUM_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE174.1_20001-1002_LASSOSUM_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode174-1-c3-breast-3-lassosum-mgi-20200608 prsweb-phecode174-1-c3-breast-3-lassosum-mgi-20200608 PRSWEB_PHECODE174.1_C3-BREAST-3_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE174.1_C3-BREAST-3_LASSOSUM_MGI_20200608 174.1 Malignant neoplasm of breast Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative lassosum UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 2267 3.4e-32 0.0241262 0.137 0.6 0.584-0.616 OR 2.37 1.54-3.65 2.37 1.54-3.65 2.08 1.5-2.88 2.08 1.5-2.88 2 1.61-2.49 2 1.61-2.49 1.84 1.56-2.18 1.84 1.56-2.18 1.95 1.72-2.21 1.95 1.72-2.21 1.27 1.04-1.54 0.0167 1.59 1.32-1.92 1.02e-06 2.5 2.09-2.97 1.61e-24 TRUE FALSE FALSE TRUE Female 1341 6444 GRCh37/hg19 s=0.5;Lambda=0.01833 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000479/ScoringFiles/ phewas/PRSWEB_PHECODE174.1_C3-BREAST-3_LASSOSUM_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE174.1_C3-BREAST-3_LASSOSUM_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode174-1-c50-lassosum-mgi-20200608 prsweb-phecode174-1-c50-lassosum-mgi-20200608 PRSWEB_PHECODE174.1_C50_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE174.1_C50_LASSOSUM_MGI_20200608 174.1 Diagnoses - main ICD10: C50 Malignant neoplasm of breast Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative lassosum UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 4047 3e-28 0.0173004 0.137 0.595 0.579-0.61 OR 2.05 1.3-3.24 2.05 1.3-3.24 1.76 1.24-2.49 1.76 1.24-2.49 1.79 1.43-2.23 1.79 1.43-2.23 1.79 1.52-2.12 1.79 1.52-2.12 1.82 1.61-2.07 1.82 1.61-2.07 1.4 1.15-1.7 0.000826 1.82 1.51-2.2 4.09e-10 2.54 2.12-3.04 3.77e-24 TRUE FALSE FALSE TRUE Female 1341 6444 GRCh37/hg19 s=0.5;Lambda=0.01833 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000483/ScoringFiles/ phewas/PRSWEB_PHECODE174.1_C50_LASSOSUM_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE174.1_C50_LASSOSUM_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode174-1-d05-lassosum-mgi-20200608 prsweb-phecode174-1-d05-lassosum-mgi-20200608 PRSWEB_PHECODE174.1_D05_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE174.1_D05_LASSOSUM_MGI_20200608 174.1 Diagnoses - main ICD10: D05 Carcinoma in situ of breast Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative lassosum UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 29211 0.093 0.00337863 0.14 0.515 0.498-0.532 OR 1.36 0.802-2.32 1.36 0.802-2.32 1.69 1.19-2.42 1.69 1.19-2.42 1.27 0.988-1.64 1.27 0.988-1.64 1.23 1.02-1.48 1.23 1.02-1.48 1.06 0.927-1.22 1.06 0.927-1.22 0.99 0.835-1.18 0.911 1.07 0.9-1.26 0.46 1.07 0.909-1.27 0.399 FALSE FALSE FALSE FALSE Female 1341 6444 GRCh37/hg19 s=1;Lambda=0.03793 2020-06-08 prsweb-phecode174-1-onco-icogs-er-negative-brca-lassosum-mgi-20200608 prsweb-phecode174-1-onco-icogs-er-negative-brca-lassosum-mgi-20200608 PRSWEB_PHECODE174.1_Onco-iCOGS-ER-negative-BRCA_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE174.1_Onco-iCOGS-ER-negative-BRCA_LASSOSUM_MGI_20200608 174.1 Breast cancer [female]; ER negative Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). MGI Michigan Genomics Initiative lassosum Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 18866 2.4e-17 0.0136313 0.138 0.571 0.555-0.588 OR 1.87 1.16-3.01 1.87 1.16-3.01 1.59 1.11-2.28 1.59 1.11-2.28 1.67 1.32-2.11 1.67 1.32-2.11 1.56 1.31-1.86 1.56 1.31-1.86 1.55 1.37-1.77 1.55 1.37-1.77 1.15 0.949-1.38 0.157 1.53 1.28-1.83 3.05e-06 1.91 1.61-2.28 2.69e-13 TRUE FALSE FALSE TRUE Female 1341 6444 GRCh37/hg19 s=0.5;Lambda=0.006952 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000495/ScoringFiles/ phewas/PRSWEB_PHECODE174.1_Onco-iCOGS-ER-negative-BRCA_LASSOSUM_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE174.1_Onco-iCOGS-ER-negative-BRCA_LASSOSUM_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode174-1-onco-icogs-er-positive-brca-lassosum-mgi-20200608 prsweb-phecode174-1-onco-icogs-er-positive-brca-lassosum-mgi-20200608 PRSWEB_PHECODE174.1_Onco-iCOGS-ER-positive-BRCA_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE174.1_Onco-iCOGS-ER-positive-BRCA_LASSOSUM_MGI_20200608 174.1 Breast cancer [female]; ER positive Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). MGI Michigan Genomics Initiative lassosum Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 61635 5.1e-54 0.0433122 0.135 0.634 0.618-0.65 OR 4.03 2.78-5.85 4.03 2.78-5.85 3.48 2.63-4.62 3.48 2.63-4.62 2.86 2.34-3.48 2.86 2.34-3.48 2.54 2.17-2.97 2.54 2.17-2.97 2.2 1.94-2.49 2.2 1.94-2.49 1.55 1.26-1.9 2.84e-05 2 1.64-2.44 6.19e-12 3.26 2.7-3.94 4.49e-35 TRUE FALSE FALSE TRUE Female 1341 6444 GRCh37/hg19 s=0.5;Lambda=0.008859 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000503/ScoringFiles/ phewas/PRSWEB_PHECODE174.1_Onco-iCOGS-ER-positive-BRCA_LASSOSUM_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE174.1_Onco-iCOGS-ER-positive-BRCA_LASSOSUM_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode174-1-onco-icogs-overall-brca-lassosum-mgi-20200608 prsweb-phecode174-1-onco-icogs-overall-brca-lassosum-mgi-20200608 PRSWEB_PHECODE174.1_Onco-iCOGS-Overall-BRCA_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE174.1_Onco-iCOGS-Overall-BRCA_LASSOSUM_MGI_20200608 174.1 Breast cancer [female], Overall Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). MGI Michigan Genomics Initiative lassosum Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 118388 1.2e-58 0.0505337 0.134 0.641 0.625-0.656 OR 2.48 1.63-3.77 2.48 1.63-3.77 2.93 2.18-3.93 2.93 2.18-3.93 3.03 2.49-3.69 3.03 2.49-3.69 2.94 2.52-3.44 2.94 2.52-3.44 2.36 2.09-2.68 2.36 2.09-2.68 1.62 1.32-1.99 5.28e-06 1.98 1.62-2.42 2.99e-11 3.49 2.89-4.22 2.71e-38 TRUE FALSE FALSE TRUE Female 1341 6444 GRCh37/hg19 s=0.5;Lambda=0.004281 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000511/ScoringFiles/ phewas/PRSWEB_PHECODE174.1_Onco-iCOGS-Overall-BRCA_LASSOSUM_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE174.1_Onco-iCOGS-Overall-BRCA_LASSOSUM_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode174-1-ukbb-saige-hrc-x174-1-lassosum-mgi-20200608 prsweb-phecode174-1-ukbb-saige-hrc-x174-1-lassosum-mgi-20200608 PRSWEB_PHECODE174.1_UKBB-SAIGE-HRC-X174.1_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE174.1_UKBB-SAIGE-HRC-X174.1_LASSOSUM_MGI_20200608 174.1 Breast cancer [female] Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative lassosum UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 6977 2.4e-36 0.0260906 0.137 0.609 0.592-0.624 OR 1.94 1.21-3.11 1.94 1.21-3.11 2.04 1.47-2.83 2.04 1.47-2.83 2.02 1.63-2.5 2.02 1.63-2.5 1.99 1.69-2.34 1.99 1.69-2.34 1.96 1.73-2.23 1.96 1.73-2.23 1.29 1.06-1.58 0.0112 1.81 1.5-2.18 7.42e-10 2.69 2.24-3.22 4.77e-27 TRUE FALSE FALSE TRUE Female 1341 6444 GRCh37/hg19 s=0.5;Lambda=0.01438 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000516/ScoringFiles/ phewas/PRSWEB_PHECODE174.1_UKBB-SAIGE-HRC-X174.1_LASSOSUM_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE174.1_UKBB-SAIGE-HRC-X174.1_LASSOSUM_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode174-1-icogs-er-negative-brca-lassosum-mgi-20200608 prsweb-phecode174-1-icogs-er-negative-brca-lassosum-mgi-20200608 PRSWEB_PHECODE174.1_iCOGS-ER-negative-BRCA_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE174.1_iCOGS-ER-negative-BRCA_LASSOSUM_MGI_20200608 174.1 Breast cancer [female]; ER negative Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). MGI Michigan Genomics Initiative lassosum Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 270 1.6e-11 0.00610521 0.139 0.546 0.529-0.562 OR 2.11 1.34-3.33 2.11 1.34-3.33 1.82 1.29-2.57 1.82 1.29-2.57 1.56 1.23-1.97 1.56 1.23-1.97 1.61 1.35-1.91 1.61 1.35-1.91 1.51 1.33-1.72 1.51 1.33-1.72 1.15 0.957-1.37 0.137 1.2 1-1.43 0.0479 1.69 1.42-2 1.29e-09 TRUE FALSE FALSE TRUE Female 1341 6444 GRCh37/hg19 s=0.9;Lambda=0.01129 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000523/ScoringFiles/ phewas/PRSWEB_PHECODE174.1_iCOGS-ER-negative-BRCA_LASSOSUM_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE174.1_iCOGS-ER-negative-BRCA_LASSOSUM_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode174-1-icogs-er-positive-brca-lassosum-mgi-20200608 prsweb-phecode174-1-icogs-er-positive-brca-lassosum-mgi-20200608 PRSWEB_PHECODE174.1_iCOGS-ER-positive-BRCA_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE174.1_iCOGS-ER-positive-BRCA_LASSOSUM_MGI_20200608 174.1 Breast cancer [female]; ER positive Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). MGI Michigan Genomics Initiative lassosum Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 98026 2.7e-38 0.0304673 0.136 0.61 0.594-0.626 OR 2.29 1.47-3.59 2.29 1.47-3.59 2.15 1.55-2.98 2.15 1.55-2.98 2.54 2.07-3.12 2.54 2.07-3.12 2.21 1.88-2.59 2.21 1.88-2.59 2.05 1.81-2.32 2.05 1.81-2.32 1.34 1.1-1.62 0.00385 1.6 1.32-1.93 1.43e-06 2.69 2.25-3.21 1.16e-27 TRUE FALSE FALSE TRUE Female 1341 6444 GRCh37/hg19 s=0.9;Lambda=0.008859 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000531/ScoringFiles/ phewas/PRSWEB_PHECODE174.1_iCOGS-ER-positive-BRCA_LASSOSUM_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE174.1_iCOGS-ER-positive-BRCA_LASSOSUM_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode174-1-icogs-overall-brca-lassosum-mgi-20200608 prsweb-phecode174-1-icogs-overall-brca-lassosum-mgi-20200608 PRSWEB_PHECODE174.1_iCOGS-Overall-BRCA_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE174.1_iCOGS-Overall-BRCA_LASSOSUM_MGI_20200608 174.1 Breast cancer [female], Overall Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). MGI Michigan Genomics Initiative lassosum Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 18356 2.7e-47 0.0336336 0.136 0.624 0.607-0.641 OR 2.49 1.61-3.84 2.49 1.61-3.84 2.8 2.08-3.78 2.8 2.08-3.78 2.61 2.14-3.2 2.61 2.14-3.2 2.22 1.89-2.6 2.22 1.89-2.6 2.14 1.89-2.42 2.14 1.89-2.42 1.54 1.25-1.89 3.62e-05 1.94 1.6-2.37 2.73e-11 3.2 2.66-3.85 1.16e-34 TRUE FALSE FALSE TRUE Female 1341 6444 GRCh37/hg19 s=0.5;Lambda=0.008859 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000539/ScoringFiles/ phewas/PRSWEB_PHECODE174.1_iCOGS-Overall-BRCA_LASSOSUM_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE174.1_iCOGS-Overall-BRCA_LASSOSUM_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode174-1-gwas-catalog-r2019-05-03-x174-1-p-5e-05-ukb-20200608 prsweb-phecode174-1-gwas-catalog-r2019-05-03-x174-1-p-5e-05-ukb-20200608 PRSWEB_PHECODE174.1_GWAS-Catalog-r2019-05-03-X174.1_P_5e-05_UKB_20200608 P_5e-05 PRSWEB_PHECODE174.1_GWAS-Catalog-r2019-05-03-X174.1_P_5e-05_UKB_20200608 174.1 Breast cancer;Breast cancer (estrogen-receptor negative);Breast Cancer in BRCA1 mutation carriers;Breast cancer in BRCA2 mutation carriers Binary 136 unique SNPs UKB UK Biobank Fixed threshold (5e-05) GWAS Catalog (2019-05-03) 17529967;17529973;17529974;18326623;19330027;19330030;20453838;20852631;20872241;21263130;21424380;23354978;23535729;23535733;23544012;23544013;25751625;29058716;29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=17529967+17529973+17529974+18326623+19330027+19330030+20453838+20852631+20872241+21263130+21424380+23354978+23535729+23535733+23544012+23544013+25751625+29058716+29059683 105 2.3e-125 0.0211669 0.0821 0.586 0.579-0.594 OR 2.24 1.86-2.7 2.24 1.86-2.7 2.08 1.81-2.39 2.08 1.81-2.39 1.92 1.75-2.11 1.92 1.75-2.11 1.8 1.68-1.93 1.8 1.68-1.93 1.72 1.63-1.82 1.72 1.63-1.82 1.31 1.2-1.42 5.02e-10 1.57 1.44-1.7 3.22e-27 2.23 2.06-2.41 1.6e-92 TRUE FALSE FALSE FALSE Female 6242 62289 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode174-1-onco-icogs-er-negative-brca-p-5e-05-ukb-20200608 prsweb-phecode174-1-onco-icogs-er-negative-brca-p-5e-05-ukb-20200608 PRSWEB_PHECODE174.1_Onco-iCOGS-ER-negative-BRCA_P_5e-05_UKB_20200608 P_5e-05 PRSWEB_PHECODE174.1_Onco-iCOGS-ER-negative-BRCA_P_5e-05_UKB_20200608 174.1 Breast cancer [female]; ER negative Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). UKB UK Biobank Fixed threshold (5e-05) Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 392 1.2e-57 0.0084719 0.0825 0.559 0.551-0.566 OR 1.75 1.42-2.15 1.75 1.42-2.15 1.64 1.41-1.91 1.64 1.41-1.91 1.6 1.44-1.76 1.6 1.44-1.76 1.57 1.46-1.7 1.57 1.46-1.7 1.46 1.38-1.54 1.46 1.38-1.54 1.14 1.06-1.24 0.000916 1.3 1.2-1.41 3.61e-11 1.68 1.56-1.81 1.82e-42 TRUE FALSE FALSE FALSE Female 6242 62289 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode174-1-onco-icogs-er-positive-brca-p-5e-05-ukb-20200608 prsweb-phecode174-1-onco-icogs-er-positive-brca-p-5e-05-ukb-20200608 PRSWEB_PHECODE174.1_Onco-iCOGS-ER-positive-BRCA_P_5e-05_UKB_20200608 P_5e-05 PRSWEB_PHECODE174.1_Onco-iCOGS-ER-positive-BRCA_P_5e-05_UKB_20200608 174.1 Breast cancer [female]; ER positive Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). UKB UK Biobank Fixed threshold (5e-05) Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 950 6.4e-226 0.0384878 0.0814 0.617 0.61-0.625 OR 3.47 2.96-4.06 3.47 2.96-4.06 2.83 2.51-3.2 2.83 2.51-3.2 2.49 2.29-2.72 2.49 2.29-2.72 2.22 2.07-2.37 2.22 2.07-2.37 2.07 1.96-2.18 2.07 1.96-2.18 1.4 1.28-1.54 1.13e-13 1.83 1.68-2 4.73e-44 2.92 2.7-3.17 4.11e-152 TRUE FALSE FALSE FALSE Female 6242 62289 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode174-1-onco-icogs-overall-brca-p-5e-05-ukb-20200608 prsweb-phecode174-1-onco-icogs-overall-brca-p-5e-05-ukb-20200608 PRSWEB_PHECODE174.1_Onco-iCOGS-Overall-BRCA_P_5e-05_UKB_20200608 P_5e-05 PRSWEB_PHECODE174.1_Onco-iCOGS-Overall-BRCA_P_5e-05_UKB_20200608 174.1 Breast cancer [female], Overall Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). UKB UK Biobank Fixed threshold (5e-05) Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 1307 7.1e-265 0.0443191 0.0812 0.627 0.62-0.634 OR 3.49 2.98-4.08 3.49 2.98-4.08 3.14 2.78-3.53 3.14 2.78-3.53 2.68 2.46-2.91 2.68 2.46-2.91 2.34 2.19-2.5 2.34 2.19-2.5 2.18 2.07-2.3 2.18 2.07-2.3 1.51 1.37-1.65 1.43e-18 1.92 1.76-2.1 8e-49 3.22 2.97-3.49 1.86e-173 TRUE FALSE FALSE FALSE Female 6242 62289 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode174-1-icogs-er-negative-brca-p-5e-05-ukb-20200608 prsweb-phecode174-1-icogs-er-negative-brca-p-5e-05-ukb-20200608 PRSWEB_PHECODE174.1_iCOGS-ER-negative-BRCA_P_5e-05_UKB_20200608 P_5e-05 PRSWEB_PHECODE174.1_iCOGS-ER-negative-BRCA_P_5e-05_UKB_20200608 174.1 Breast cancer [female]; ER negative Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). UKB UK Biobank Fixed threshold (5e-05) Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 158 3.1e-12 0.00204393 0.0827 0.526 0.518-0.533 OR 1.21 0.952-1.54 1.21 0.952-1.54 1.28 1.09-1.52 1.28 1.09-1.52 1.21 1.09-1.35 1.21 1.09-1.35 1.18 1.09-1.28 1.18 1.09-1.28 1.12 1.05-1.18 1.12 1.05-1.18 1.04 0.965-1.13 0.294 1.22 1.13-1.32 1.14e-07 1.22 1.13-1.31 2.49e-07 TRUE FALSE FALSE FALSE Female 6242 62289 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode174-1-icogs-er-positive-brca-p-5e-05-ukb-20200608 prsweb-phecode174-1-icogs-er-positive-brca-p-5e-05-ukb-20200608 PRSWEB_PHECODE174.1_iCOGS-ER-positive-BRCA_P_5e-05_UKB_20200608 P_5e-05 PRSWEB_PHECODE174.1_iCOGS-ER-positive-BRCA_P_5e-05_UKB_20200608 174.1 Breast cancer [female]; ER positive Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). UKB UK Biobank Fixed threshold (5e-05) Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 423 1.5e-150 0.0235116 0.0819 0.596 0.589-0.603 OR 2.49 2.08-2.98 2.49 2.08-2.98 2.21 1.93-2.53 2.21 1.93-2.53 2.12 1.94-2.32 2.12 1.94-2.32 1.93 1.8-2.07 1.93 1.8-2.07 1.81 1.71-1.91 1.81 1.71-1.91 1.3 1.2-1.42 1.45e-09 1.66 1.53-1.8 9.02e-34 2.39 2.21-2.58 8.46e-107 TRUE FALSE FALSE FALSE Female 6242 62289 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode174-1-icogs-overall-brca-p-5e-05-ukb-20200608 prsweb-phecode174-1-icogs-overall-brca-p-5e-05-ukb-20200608 PRSWEB_PHECODE174.1_iCOGS-Overall-BRCA_P_5e-05_UKB_20200608 P_5e-05 PRSWEB_PHECODE174.1_iCOGS-Overall-BRCA_P_5e-05_UKB_20200608 174.1 Breast cancer [female], Overall Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). UKB UK Biobank Fixed threshold (5e-05) Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 534 3e-162 0.0258641 0.0818 0.6 0.593-0.608 OR 2.86 2.41-3.39 2.86 2.41-3.39 2.58 2.27-2.93 2.58 2.27-2.93 2.08 1.9-2.28 2.08 1.9-2.28 1.96 1.83-2.1 1.96 1.83-2.1 1.8 1.7-1.9 1.8 1.7-1.9 1.33 1.22-1.45 2.08e-10 1.76 1.62-1.92 1.5e-41 2.45 2.27-2.65 3.84e-111 TRUE FALSE FALSE FALSE Female 6242 62289 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode174-1-gwas-catalog-r2019-05-03-x174-1-p-5e-06-ukb-20200608 prsweb-phecode174-1-gwas-catalog-r2019-05-03-x174-1-p-5e-06-ukb-20200608 PRSWEB_PHECODE174.1_GWAS-Catalog-r2019-05-03-X174.1_P_5e-06_UKB_20200608 P_5e-06 PRSWEB_PHECODE174.1_GWAS-Catalog-r2019-05-03-X174.1_P_5e-06_UKB_20200608 174.1 Breast cancer;Breast cancer (estrogen-receptor negative);Breast Cancer in BRCA1 mutation carriers;Breast cancer in BRCA2 mutation carriers Binary 136 unique SNPs UKB UK Biobank Fixed threshold (5e-06) GWAS Catalog (2019-05-03) 17529967;17529973;17529974;18326623;19330027;19330030;20453838;20852631;20872241;21263130;21424380;23354978;23535729;23535733;23544012;23544013;25751625;29058716;29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=17529967+17529973+17529974+18326623+19330027+19330030+20453838+20852631+20872241+21263130+21424380+23354978+23535729+23535733+23544012+23544013+25751625+29058716+29059683 102 6.3e-132 0.0230285 0.082 0.589 0.582-0.597 OR 2.26 1.88-2.72 2.26 1.88-2.72 2.08 1.81-2.39 2.08 1.81-2.39 1.97 1.8-2.16 1.97 1.8-2.16 1.83 1.71-1.97 1.83 1.71-1.97 1.74 1.64-1.83 1.74 1.64-1.83 1.38 1.27-1.51 7.66e-14 1.65 1.52-1.79 1.26e-32 2.34 2.16-2.53 6.94e-101 TRUE FALSE FALSE FALSE Female 6242 62289 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode174-1-onco-icogs-er-negative-brca-p-5e-06-ukb-20200608 prsweb-phecode174-1-onco-icogs-er-negative-brca-p-5e-06-ukb-20200608 PRSWEB_PHECODE174.1_Onco-iCOGS-ER-negative-BRCA_P_5e-06_UKB_20200608 P_5e-06 PRSWEB_PHECODE174.1_Onco-iCOGS-ER-negative-BRCA_P_5e-06_UKB_20200608 174.1 Breast cancer [female]; ER negative Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). UKB UK Biobank Fixed threshold (5e-06) Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 133 2.5e-64 0.0083826 0.0824 0.561 0.553-0.568 OR 1.81 1.48-2.22 1.81 1.48-2.22 1.82 1.57-2.1 1.82 1.57-2.1 1.67 1.51-1.84 1.67 1.51-1.84 1.48 1.37-1.6 1.48 1.37-1.6 1.38 1.31-1.46 1.38 1.31-1.46 1.2 1.11-1.3 8.03e-06 1.49 1.38-1.61 8.1e-24 1.7 1.58-1.84 4.49e-43 TRUE FALSE FALSE FALSE Female 6242 62289 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode174-1-onco-icogs-er-positive-brca-p-5e-06-ukb-20200608 prsweb-phecode174-1-onco-icogs-er-positive-brca-p-5e-06-ukb-20200608 PRSWEB_PHECODE174.1_Onco-iCOGS-ER-positive-BRCA_P_5e-06_UKB_20200608 P_5e-06 PRSWEB_PHECODE174.1_Onco-iCOGS-ER-positive-BRCA_P_5e-06_UKB_20200608 174.1 Breast cancer [female]; ER positive Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). UKB UK Biobank Fixed threshold (5e-06) Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 495 2.2e-225 0.0389156 0.0814 0.617 0.61-0.625 OR 3.06 2.6-3.61 3.06 2.6-3.61 2.74 2.42-3.11 2.74 2.42-3.11 2.45 2.25-2.67 2.45 2.25-2.67 2.27 2.12-2.43 2.27 2.12-2.43 2.05 1.94-2.16 2.05 1.94-2.16 1.45 1.33-1.59 3.4e-16 1.89 1.73-2.06 9.02e-48 2.97 2.74-3.22 3.56e-154 TRUE FALSE FALSE FALSE Female 6242 62289 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode174-1-onco-icogs-overall-brca-p-5e-06-ukb-20200608 prsweb-phecode174-1-onco-icogs-overall-brca-p-5e-06-ukb-20200608 PRSWEB_PHECODE174.1_Onco-iCOGS-Overall-BRCA_P_5e-06_UKB_20200608 P_5e-06 PRSWEB_PHECODE174.1_Onco-iCOGS-Overall-BRCA_P_5e-06_UKB_20200608 174.1 Breast cancer [female], Overall Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). UKB UK Biobank Fixed threshold (5e-06) Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 712 1.5e-271 0.0437374 0.0811 0.628 0.62-0.635 OR 3.69 3.16-4.31 3.69 3.16-4.31 3.16 2.81-3.56 3.16 2.81-3.56 2.71 2.49-2.94 2.71 2.49-2.94 2.41 2.26-2.58 2.41 2.26-2.58 2.13 2.02-2.25 2.13 2.02-2.25 1.61 1.46-1.76 8.15e-24 2.09 1.92-2.29 1.8e-60 3.34 3.07-3.63 1.99e-177 TRUE FALSE FALSE FALSE Female 6242 62289 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode174-1-icogs-er-negative-brca-p-5e-06-ukb-20200608 prsweb-phecode174-1-icogs-er-negative-brca-p-5e-06-ukb-20200608 PRSWEB_PHECODE174.1_iCOGS-ER-negative-BRCA_P_5e-06_UKB_20200608 P_5e-06 PRSWEB_PHECODE174.1_iCOGS-ER-negative-BRCA_P_5e-06_UKB_20200608 174.1 Breast cancer [female]; ER negative Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). UKB UK Biobank Fixed threshold (5e-06) Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 35 8.5e-28 0.00333191 0.0826 0.537 0.53-0.545 OR 1.39 1.11-1.74 1.39 1.11-1.74 1.51 1.29-1.76 1.51 1.29-1.76 1.42 1.28-1.57 1.42 1.28-1.57 1.33 1.23-1.43 1.33 1.23-1.43 1.27 1.2-1.34 1.27 1.2-1.34 1.16 1.07-1.25 0.000258 1.29 1.2-1.4 4.24e-11 1.46 1.35-1.57 3.81e-23 TRUE FALSE FALSE FALSE Female 6242 62289 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode174-1-icogs-er-positive-brca-p-5e-06-ukb-20200608 prsweb-phecode174-1-icogs-er-positive-brca-p-5e-06-ukb-20200608 PRSWEB_PHECODE174.1_iCOGS-ER-positive-BRCA_P_5e-06_UKB_20200608 P_5e-06 PRSWEB_PHECODE174.1_iCOGS-ER-positive-BRCA_P_5e-06_UKB_20200608 174.1 Breast cancer [female]; ER positive Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). UKB UK Biobank Fixed threshold (5e-06) Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 185 6.6e-168 0.0285405 0.0818 0.6 0.593-0.608 OR 2.74 2.31-3.26 2.74 2.31-3.26 2.41 2.11-2.74 2.41 2.11-2.74 2.04 1.86-2.23 2.04 1.86-2.23 1.92 1.79-2.06 1.92 1.79-2.06 1.93 1.83-2.04 1.93 1.83-2.04 1.41 1.29-1.54 8.62e-15 1.66 1.53-1.81 2.64e-32 2.63 2.43-2.84 6.7e-128 TRUE FALSE FALSE FALSE Female 6242 62289 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode174-1-icogs-overall-brca-p-5e-06-ukb-20200608 prsweb-phecode174-1-icogs-overall-brca-p-5e-06-ukb-20200608 PRSWEB_PHECODE174.1_iCOGS-Overall-BRCA_P_5e-06_UKB_20200608 P_5e-06 PRSWEB_PHECODE174.1_iCOGS-Overall-BRCA_P_5e-06_UKB_20200608 174.1 Breast cancer [female], Overall Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). UKB UK Biobank Fixed threshold (5e-06) Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 246 4.1e-175 0.0291108 0.0817 0.603 0.595-0.61 OR 2.87 2.43-3.4 2.87 2.43-3.4 2.46 2.16-2.8 2.46 2.16-2.8 2.29 2.1-2.5 2.29 2.1-2.5 2.01 1.88-2.15 2.01 1.88-2.15 1.9 1.8-2.01 1.9 1.8-2.01 1.34 1.23-1.47 3.38e-11 1.72 1.58-1.87 3.13e-37 2.58 2.39-2.79 1.02e-123 TRUE FALSE FALSE FALSE Female 6242 62289 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode174-1-gwas-catalog-r2019-05-03-x174-1-p-5e-07-ukb-20200608 prsweb-phecode174-1-gwas-catalog-r2019-05-03-x174-1-p-5e-07-ukb-20200608 PRSWEB_PHECODE174.1_GWAS-Catalog-r2019-05-03-X174.1_P_5e-07_UKB_20200608 P_5e-07 PRSWEB_PHECODE174.1_GWAS-Catalog-r2019-05-03-X174.1_P_5e-07_UKB_20200608 174.1 Breast cancer;Breast cancer (estrogen-receptor negative);Breast Cancer in BRCA1 mutation carriers;Breast cancer in BRCA2 mutation carriers Binary 136 unique SNPs UKB UK Biobank Fixed threshold (5e-07) GWAS Catalog (2019-05-03) 17529967;17529973;17529974;18326623;19330027;19330030;20453838;20852631;20872241;21263130;21424380;23354978;23535729;23535733;23544012;23544013;25751625;29058716;29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=17529967+17529973+17529974+18326623+19330027+19330030+20453838+20852631+20872241+21263130+21424380+23354978+23535729+23535733+23544012+23544013+25751625+29058716+29059683 93 1.7e-144 0.0248677 0.0819 0.594 0.586-0.601 OR 2.58 2.16-3.08 2.58 2.16-3.08 2.34 2.05-2.67 2.34 2.05-2.67 2.05 1.87-2.25 2.05 1.87-2.25 1.91 1.78-2.05 1.91 1.78-2.05 1.74 1.64-1.83 1.74 1.64-1.83 1.44 1.32-1.56 1.87e-16 1.76 1.62-1.92 5.22e-41 2.43 2.25-2.63 2.01e-107 TRUE FALSE FALSE FALSE Female 6242 62289 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode174-1-onco-icogs-er-negative-brca-p-5e-07-ukb-20200608 prsweb-phecode174-1-onco-icogs-er-negative-brca-p-5e-07-ukb-20200608 PRSWEB_PHECODE174.1_Onco-iCOGS-ER-negative-BRCA_P_5e-07_UKB_20200608 P_5e-07 PRSWEB_PHECODE174.1_Onco-iCOGS-ER-negative-BRCA_P_5e-07_UKB_20200608 174.1 Breast cancer [female]; ER negative Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). UKB UK Biobank Fixed threshold (5e-07) Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 73 7.7e-61 0.00809412 0.0824 0.56 0.552-0.567 OR 1.76 1.44-2.16 1.76 1.44-2.16 1.95 1.7-2.25 1.95 1.7-2.25 1.65 1.49-1.82 1.65 1.49-1.82 1.49 1.38-1.61 1.49 1.38-1.61 1.43 1.35-1.51 1.43 1.35-1.51 1.17 1.08-1.26 0.000188 1.41 1.3-1.52 5.14e-18 1.7 1.58-1.83 1.34e-43 TRUE FALSE FALSE FALSE Female 6242 62289 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode174-1-onco-icogs-er-positive-brca-p-5e-07-ukb-20200608 prsweb-phecode174-1-onco-icogs-er-positive-brca-p-5e-07-ukb-20200608 PRSWEB_PHECODE174.1_Onco-iCOGS-ER-positive-BRCA_P_5e-07_UKB_20200608 P_5e-07 PRSWEB_PHECODE174.1_Onco-iCOGS-ER-positive-BRCA_P_5e-07_UKB_20200608 174.1 Breast cancer [female]; ER positive Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). UKB UK Biobank Fixed threshold (5e-07) Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 343 3.1e-218 0.0375986 0.0815 0.615 0.607-0.622 OR 3.01 2.55-3.56 3.01 2.55-3.56 2.86 2.53-3.23 2.86 2.53-3.23 2.38 2.18-2.6 2.38 2.18-2.6 2.19 2.05-2.35 2.19 2.05-2.35 2.02 1.91-2.13 2.02 1.91-2.13 1.44 1.31-1.57 1.65e-15 1.84 1.69-2.01 1.12e-44 2.88 2.66-3.12 1.5e-147 TRUE FALSE FALSE FALSE Female 6242 62289 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode174-1-onco-icogs-overall-brca-p-5e-07-ukb-20200608 prsweb-phecode174-1-onco-icogs-overall-brca-p-5e-07-ukb-20200608 PRSWEB_PHECODE174.1_Onco-iCOGS-Overall-BRCA_P_5e-07_UKB_20200608 P_5e-07 PRSWEB_PHECODE174.1_Onco-iCOGS-Overall-BRCA_P_5e-07_UKB_20200608 174.1 Breast cancer [female], Overall Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). UKB UK Biobank Fixed threshold (5e-07) Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 464 2.3e-260 0.0434102 0.0812 0.626 0.618-0.633 OR 3.81 3.27-4.44 3.81 3.27-4.44 3.19 2.83-3.59 3.19 2.83-3.59 2.53 2.33-2.76 2.53 2.33-2.76 2.4 2.24-2.56 2.4 2.24-2.56 2.14 2.03-2.26 2.14 2.03-2.26 1.55 1.41-1.7 6.18e-21 1.98 1.82-2.16 7.21e-53 3.23 2.98-3.51 1.65e-172 TRUE FALSE FALSE FALSE Female 6242 62289 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode174-1-icogs-er-negative-brca-p-5e-07-ukb-20200608 prsweb-phecode174-1-icogs-er-negative-brca-p-5e-07-ukb-20200608 PRSWEB_PHECODE174.1_iCOGS-ER-negative-BRCA_P_5e-07_UKB_20200608 P_5e-07 PRSWEB_PHECODE174.1_iCOGS-ER-negative-BRCA_P_5e-07_UKB_20200608 174.1 Breast cancer [female]; ER negative Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). UKB UK Biobank Fixed threshold (5e-07) Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 14 2.2e-44 0.00581917 0.0825 0.547 0.54-0.555 OR 1.73 1.41-2.13 1.73 1.41-2.13 1.63 1.4-1.89 1.63 1.4-1.89 1.51 1.36-1.67 1.51 1.36-1.67 1.39 1.29-1.5 1.39 1.29-1.5 1.38 1.3-1.46 1.38 1.3-1.46 1.2 1.1-1.29 1.11e-05 1.35 1.25-1.46 6.02e-14 1.63 1.51-1.76 3.48e-37 TRUE FALSE FALSE FALSE Female 6242 62289 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode174-1-icogs-er-positive-brca-p-5e-07-ukb-20200608 prsweb-phecode174-1-icogs-er-positive-brca-p-5e-07-ukb-20200608 PRSWEB_PHECODE174.1_iCOGS-ER-positive-BRCA_P_5e-07_UKB_20200608 P_5e-07 PRSWEB_PHECODE174.1_iCOGS-ER-positive-BRCA_P_5e-07_UKB_20200608 174.1 Breast cancer [female]; ER positive Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). UKB UK Biobank Fixed threshold (5e-07) Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 113 2.7e-162 0.027191 0.0818 0.597 0.59-0.604 OR 2.71 2.28-3.22 2.71 2.28-3.22 2.46 2.16-2.8 2.46 2.16-2.8 2.1 1.92-2.3 2.1 1.92-2.3 1.97 1.83-2.11 1.97 1.83-2.11 1.82 1.72-1.92 1.82 1.72-1.92 1.34 1.23-1.46 5.84e-11 1.74 1.61-1.89 1.13e-39 2.48 2.29-2.68 6.35e-114 TRUE FALSE FALSE FALSE Female 6242 62289 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode174-1-icogs-overall-brca-p-5e-07-ukb-20200608 prsweb-phecode174-1-icogs-overall-brca-p-5e-07-ukb-20200608 PRSWEB_PHECODE174.1_iCOGS-Overall-BRCA_P_5e-07_UKB_20200608 P_5e-07 PRSWEB_PHECODE174.1_iCOGS-Overall-BRCA_P_5e-07_UKB_20200608 174.1 Breast cancer [female], Overall Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). UKB UK Biobank Fixed threshold (5e-07) Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 154 6.6e-176 0.0295653 0.0818 0.603 0.595-0.61 OR 2.65 2.22-3.15 2.65 2.22-3.15 2.27 1.99-2.6 2.27 1.99-2.6 2.19 2-2.39 2.19 2-2.39 1.99 1.85-2.13 1.99 1.85-2.13 1.94 1.84-2.04 1.94 1.84-2.04 1.3 1.19-1.42 3.12e-09 1.67 1.54-1.82 1.25e-33 2.57 2.38-2.78 3.55e-124 TRUE FALSE FALSE FALSE Female 6242 62289 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode174-1-gwas-catalog-r2019-05-03-x174-1-p-5e-09-ukb-20200608 prsweb-phecode174-1-gwas-catalog-r2019-05-03-x174-1-p-5e-09-ukb-20200608 PRSWEB_PHECODE174.1_GWAS-Catalog-r2019-05-03-X174.1_P_5e-09_UKB_20200608 P_5e-09 PRSWEB_PHECODE174.1_GWAS-Catalog-r2019-05-03-X174.1_P_5e-09_UKB_20200608 174.1 Breast cancer;Breast cancer (estrogen-receptor negative);Breast Cancer in BRCA1 mutation carriers;Breast cancer in BRCA2 mutation carriers Binary 136 unique SNPs UKB UK Biobank Fixed threshold (5e-09) GWAS Catalog (2019-05-03) 17529967;17529973;17529974;18326623;19330027;19330030;20453838;20852631;20872241;21263130;21424380;23354978;23535729;23535733;23544012;23544013;25751625;29058716;29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=17529967+17529973+17529974+18326623+19330027+19330030+20453838+20852631+20872241+21263130+21424380+23354978+23535729+23535733+23544012+23544013+25751625+29058716+29059683 64 1.2e-146 0.0254827 0.0819 0.595 0.588-0.602 OR 2.44 2.04-2.92 2.44 2.04-2.92 2.33 2.04-2.66 2.33 2.04-2.66 2.1 1.92-2.3 2.1 1.92-2.3 1.93 1.8-2.07 1.93 1.8-2.07 1.79 1.69-1.89 1.79 1.69-1.89 1.33 1.22-1.45 4.62e-11 1.69 1.55-1.83 1.18e-35 2.39 2.21-2.59 1.66e-106 TRUE FALSE FALSE FALSE Female 6242 62289 GRCh37/hg19 P<=5e-09 2020-06-08 prsweb-phecode174-1-onco-icogs-er-negative-brca-p-5e-09-ukb-20200608 prsweb-phecode174-1-onco-icogs-er-negative-brca-p-5e-09-ukb-20200608 PRSWEB_PHECODE174.1_Onco-iCOGS-ER-negative-BRCA_P_5e-09_UKB_20200608 P_5e-09 PRSWEB_PHECODE174.1_Onco-iCOGS-ER-negative-BRCA_P_5e-09_UKB_20200608 174.1 Breast cancer [female]; ER negative Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). UKB UK Biobank Fixed threshold (5e-09) Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 31 1.3e-56 0.00782901 0.0825 0.556 0.548-0.564 OR 1.95 1.6-2.37 1.95 1.6-2.37 1.8 1.56-2.08 1.8 1.56-2.08 1.73 1.57-1.9 1.73 1.57-1.9 1.53 1.42-1.65 1.53 1.42-1.65 1.44 1.36-1.52 1.44 1.36-1.52 1.22 1.12-1.32 1.49e-06 1.33 1.23-1.44 1.46e-12 1.7 1.58-1.83 1.08e-43 TRUE FALSE FALSE FALSE Female 6242 62289 GRCh37/hg19 P<=5e-09 2020-06-08 prsweb-phecode174-1-onco-icogs-er-positive-brca-p-5e-09-ukb-20200608 prsweb-phecode174-1-onco-icogs-er-positive-brca-p-5e-09-ukb-20200608 PRSWEB_PHECODE174.1_Onco-iCOGS-ER-positive-BRCA_P_5e-09_UKB_20200608 P_5e-09 PRSWEB_PHECODE174.1_Onco-iCOGS-ER-positive-BRCA_P_5e-09_UKB_20200608 174.1 Breast cancer [female]; ER positive Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). UKB UK Biobank Fixed threshold (5e-09) Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 210 1.6e-200 0.0339286 0.0816 0.61 0.603-0.617 OR 2.7 2.27-3.21 2.7 2.27-3.21 2.53 2.23-2.87 2.53 2.23-2.87 2.35 2.16-2.57 2.35 2.16-2.57 2.17 2.03-2.33 2.17 2.03-2.33 1.99 1.89-2.1 1.99 1.89-2.1 1.36 1.25-1.49 7.17e-12 1.79 1.64-1.95 1.57e-41 2.75 2.54-2.98 1.76e-138 TRUE FALSE FALSE FALSE Female 6242 62289 GRCh37/hg19 P<=5e-09 2020-06-08 prsweb-phecode174-1-onco-icogs-overall-brca-p-5e-09-ukb-20200608 prsweb-phecode174-1-onco-icogs-overall-brca-p-5e-09-ukb-20200608 PRSWEB_PHECODE174.1_Onco-iCOGS-Overall-BRCA_P_5e-09_UKB_20200608 P_5e-09 PRSWEB_PHECODE174.1_Onco-iCOGS-Overall-BRCA_P_5e-09_UKB_20200608 174.1 Breast cancer [female], Overall Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). UKB UK Biobank Fixed threshold (5e-09) Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 264 1.4e-236 0.0390059 0.0813 0.62 0.612-0.627 OR 3.28 2.79-3.86 3.28 2.79-3.86 2.92 2.59-3.3 2.92 2.59-3.3 2.57 2.36-2.79 2.57 2.36-2.79 2.28 2.14-2.44 2.28 2.14-2.44 2.09 1.98-2.21 2.09 1.98-2.21 1.44 1.31-1.57 2.77e-15 1.89 1.73-2.06 1.73e-47 3.02 2.78-3.27 1.49e-158 TRUE FALSE FALSE FALSE Female 6242 62289 GRCh37/hg19 P<=5e-09 2020-06-08 prsweb-phecode174-1-icogs-er-negative-brca-p-5e-09-ukb-20200608 prsweb-phecode174-1-icogs-er-negative-brca-p-5e-09-ukb-20200608 PRSWEB_PHECODE174.1_iCOGS-ER-negative-BRCA_P_5e-09_UKB_20200608 P_5e-09 PRSWEB_PHECODE174.1_iCOGS-ER-negative-BRCA_P_5e-09_UKB_20200608 174.1 Breast cancer [female]; ER negative Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). UKB UK Biobank Fixed threshold (5e-09) Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 8 5e-31 0.00425293 0.0826 0.536 0.528-0.544 OR 1.77 1.44-2.17 1.77 1.44-2.17 1.57 1.35-1.83 1.57 1.35-1.83 1.31 1.18-1.46 1.31 1.18-1.46 1.26 1.16-1.37 1.26 1.16-1.37 1.32 1.25-1.4 1.32 1.25-1.4 1.19 1.1-1.28 1.75e-05 1.25 1.16-1.35 1.21e-08 1.52 1.41-1.63 4.77e-28 TRUE FALSE FALSE FALSE Female 6242 62289 GRCh37/hg19 P<=5e-09 2020-06-08 prsweb-phecode174-1-icogs-er-positive-brca-p-5e-09-ukb-20200608 prsweb-phecode174-1-icogs-er-positive-brca-p-5e-09-ukb-20200608 PRSWEB_PHECODE174.1_iCOGS-ER-positive-BRCA_P_5e-09_UKB_20200608 P_5e-09 PRSWEB_PHECODE174.1_iCOGS-ER-positive-BRCA_P_5e-09_UKB_20200608 174.1 Breast cancer [female]; ER positive Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). UKB UK Biobank Fixed threshold (5e-09) Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 63 6e-150 0.0272888 0.0819 0.593 0.586-0.6 OR 2.76 2.33-3.28 2.76 2.33-3.28 2.31 2.02-2.63 2.31 2.02-2.63 2.04 1.86-2.24 2.04 1.86-2.24 1.95 1.82-2.09 1.95 1.82-2.09 1.79 1.69-1.89 1.79 1.69-1.89 1.31 1.2-1.42 1.13e-09 1.67 1.54-1.81 2.33e-34 2.37 2.19-2.56 1.89e-104 TRUE FALSE FALSE FALSE Female 6242 62289 GRCh37/hg19 P<=5e-09 2020-06-08 prsweb-phecode174-1-icogs-overall-brca-p-5e-09-ukb-20200608 prsweb-phecode174-1-icogs-overall-brca-p-5e-09-ukb-20200608 PRSWEB_PHECODE174.1_iCOGS-Overall-BRCA_P_5e-09_UKB_20200608 P_5e-09 PRSWEB_PHECODE174.1_iCOGS-Overall-BRCA_P_5e-09_UKB_20200608 174.1 Breast cancer [female], Overall Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). UKB UK Biobank Fixed threshold (5e-09) Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 77 2e-168 0.0298674 0.0818 0.6 0.593-0.607 OR 2.58 2.16-3.08 2.58 2.16-3.08 2.4 2.11-2.74 2.4 2.11-2.74 2.13 1.94-2.33 2.13 1.94-2.33 1.99 1.86-2.13 1.99 1.86-2.13 1.86 1.77-1.97 1.86 1.77-1.97 1.26 1.16-1.38 1.72e-07 1.71 1.57-1.85 2.63e-37 2.47 2.28-2.67 1.92e-114 TRUE FALSE FALSE FALSE Female 6242 62289 GRCh37/hg19 P<=5e-09 2020-06-08 prsweb-phecode174-1-gwas-catalog-r2019-05-03-x174-1-p-5e-08-ukb-20200608 prsweb-phecode174-1-gwas-catalog-r2019-05-03-x174-1-p-5e-08-ukb-20200608 PRSWEB_PHECODE174.1_GWAS-Catalog-r2019-05-03-X174.1_P_5e-08_UKB_20200608 P_5e-08 PRSWEB_PHECODE174.1_GWAS-Catalog-r2019-05-03-X174.1_P_5e-08_UKB_20200608 174.1 Breast cancer;Breast cancer (estrogen-receptor negative);Breast Cancer in BRCA1 mutation carriers;Breast cancer in BRCA2 mutation carriers Binary 136 unique SNPs UKB UK Biobank GWAS Hits GWAS Catalog (2019-05-03) 17529967;17529973;17529974;18326623;19330027;19330030;20453838;20852631;20872241;21263130;21424380;23354978;23535729;23535733;23544012;23544013;25751625;29058716;29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=17529967+17529973+17529974+18326623+19330027+19330030+20453838+20852631+20872241+21263130+21424380+23354978+23535729+23535733+23544012+23544013+25751625+29058716+29059683 86 3.9e-139 0.0244675 0.082 0.592 0.585-0.6 OR 2.58 2.16-3.07 2.58 2.16-3.07 2.37 2.08-2.7 2.37 2.08-2.7 2.04 1.87-2.24 2.04 1.87-2.24 1.85 1.72-1.98 1.85 1.72-1.98 1.72 1.63-1.82 1.72 1.63-1.82 1.42 1.3-1.54 1.99e-15 1.76 1.62-1.91 6.72e-41 2.4 2.22-2.59 1.05e-104 TRUE FALSE FALSE TRUE Female 6242 62289 GRCh37/hg19 P<=5e-08 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000486/ScoringFiles/ phewas/PRSWEB_PHECODE174.1_GWAS-Catalog-r2019-05-03-X174.1_P_5e-08_UKB_20200608/all.tsv phewas/PRSWEB_PHECODE174.1_GWAS-Catalog-r2019-05-03-X174.1_P_5e-08_UKB_20200608/exclusion.tsv 2020-06-08 prsweb-phecode174-1-onco-icogs-er-negative-brca-p-5e-08-ukb-20200608 prsweb-phecode174-1-onco-icogs-er-negative-brca-p-5e-08-ukb-20200608 PRSWEB_PHECODE174.1_Onco-iCOGS-ER-negative-BRCA_P_5e-08_UKB_20200608 P_5e-08 PRSWEB_PHECODE174.1_Onco-iCOGS-ER-negative-BRCA_P_5e-08_UKB_20200608 174.1 Breast cancer [female]; ER negative Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). UKB UK Biobank GWAS Hits Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 49 8.9e-63 0.00912193 0.0824 0.559 0.551-0.566 OR 2.03 1.67-2.46 2.03 1.67-2.46 1.98 1.72-2.28 1.98 1.72-2.28 1.63 1.48-1.8 1.63 1.48-1.8 1.59 1.47-1.71 1.59 1.47-1.71 1.45 1.38-1.54 1.45 1.38-1.54 1.26 1.16-1.36 2.24e-08 1.37 1.27-1.49 3.23e-15 1.76 1.63-1.9 7.25e-49 TRUE FALSE FALSE TRUE Female 6242 62289 GRCh37/hg19 P<=5e-08 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000490/ScoringFiles/ phewas/PRSWEB_PHECODE174.1_Onco-iCOGS-ER-negative-BRCA_P_5e-08_UKB_20200608/all.tsv phewas/PRSWEB_PHECODE174.1_Onco-iCOGS-ER-negative-BRCA_P_5e-08_UKB_20200608/exclusion.tsv 2020-06-08 prsweb-phecode174-1-onco-icogs-er-positive-brca-p-5e-08-ukb-20200608 prsweb-phecode174-1-onco-icogs-er-positive-brca-p-5e-08-ukb-20200608 PRSWEB_PHECODE174.1_Onco-iCOGS-ER-positive-BRCA_P_5e-08_UKB_20200608 P_5e-08 PRSWEB_PHECODE174.1_Onco-iCOGS-ER-positive-BRCA_P_5e-08_UKB_20200608 174.1 Breast cancer [female]; ER positive Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). UKB UK Biobank GWAS Hits Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 257 1.8e-212 0.0361392 0.0815 0.613 0.606-0.621 OR 2.71 2.28-3.23 2.71 2.28-3.23 2.61 2.3-2.96 2.61 2.3-2.96 2.41 2.21-2.63 2.41 2.21-2.63 2.25 2.1-2.41 2.25 2.1-2.41 2 1.9-2.11 2 1.9-2.11 1.43 1.31-1.57 2.45e-15 1.87 1.72-2.03 7.66e-47 2.87 2.65-3.11 2.87e-146 TRUE FALSE FALSE TRUE Female 6242 62289 GRCh37/hg19 P<=5e-08 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000498/ScoringFiles/ phewas/PRSWEB_PHECODE174.1_Onco-iCOGS-ER-positive-BRCA_P_5e-08_UKB_20200608/all.tsv phewas/PRSWEB_PHECODE174.1_Onco-iCOGS-ER-positive-BRCA_P_5e-08_UKB_20200608/exclusion.tsv 2020-06-08 prsweb-phecode174-1-onco-icogs-overall-brca-p-5e-08-ukb-20200608 prsweb-phecode174-1-onco-icogs-overall-brca-p-5e-08-ukb-20200608 PRSWEB_PHECODE174.1_Onco-iCOGS-Overall-BRCA_P_5e-08_UKB_20200608 P_5e-08 PRSWEB_PHECODE174.1_Onco-iCOGS-Overall-BRCA_P_5e-08_UKB_20200608 174.1 Breast cancer [female], Overall Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). UKB UK Biobank GWAS Hits Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 334 2.5e-245 0.0408759 0.0813 0.622 0.615-0.63 OR 3.69 3.16-4.31 3.69 3.16-4.31 2.94 2.6-3.32 2.94 2.6-3.32 2.49 2.28-2.71 2.49 2.28-2.71 2.26 2.11-2.42 2.26 2.11-2.42 2.09 1.98-2.21 2.09 1.98-2.21 1.51 1.38-1.66 5.03e-19 1.96 1.8-2.14 3.8e-52 3.12 2.87-3.38 2.94e-164 TRUE FALSE FALSE TRUE Female 6242 62289 GRCh37/hg19 P<=5e-08 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000506/ScoringFiles/ phewas/PRSWEB_PHECODE174.1_Onco-iCOGS-Overall-BRCA_P_5e-08_UKB_20200608/all.tsv phewas/PRSWEB_PHECODE174.1_Onco-iCOGS-Overall-BRCA_P_5e-08_UKB_20200608/exclusion.tsv 2020-06-08 prsweb-phecode174-1-icogs-er-negative-brca-p-5e-08-ukb-20200608 prsweb-phecode174-1-icogs-er-negative-brca-p-5e-08-ukb-20200608 PRSWEB_PHECODE174.1_iCOGS-ER-negative-BRCA_P_5e-08_UKB_20200608 P_5e-08 PRSWEB_PHECODE174.1_iCOGS-ER-negative-BRCA_P_5e-08_UKB_20200608 174.1 Breast cancer [female]; ER negative Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). UKB UK Biobank GWAS Hits Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 10 1.8e-36 0.0048623 0.0826 0.542 0.534-0.55 OR 1.49 1.2-1.86 1.49 1.2-1.86 1.43 1.22-1.68 1.43 1.22-1.68 1.42 1.28-1.57 1.42 1.28-1.57 1.32 1.22-1.42 1.32 1.22-1.42 1.33 1.25-1.4 1.33 1.25-1.4 1.16 1.07-1.25 0.000277 1.31 1.21-1.42 5.25e-12 1.53 1.42-1.65 3.22e-29 TRUE FALSE FALSE TRUE Female 6242 62289 GRCh37/hg19 P<=5e-08 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000518/ScoringFiles/ phewas/PRSWEB_PHECODE174.1_iCOGS-ER-negative-BRCA_P_5e-08_UKB_20200608/all.tsv phewas/PRSWEB_PHECODE174.1_iCOGS-ER-negative-BRCA_P_5e-08_UKB_20200608/exclusion.tsv 2020-06-08 prsweb-phecode174-1-icogs-er-positive-brca-p-5e-08-ukb-20200608 prsweb-phecode174-1-icogs-er-positive-brca-p-5e-08-ukb-20200608 PRSWEB_PHECODE174.1_iCOGS-ER-positive-BRCA_P_5e-08_UKB_20200608 P_5e-08 PRSWEB_PHECODE174.1_iCOGS-ER-positive-BRCA_P_5e-08_UKB_20200608 174.1 Breast cancer [female]; ER positive Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). UKB UK Biobank GWAS Hits Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 86 1.1e-157 0.027687 0.0819 0.597 0.59-0.604 OR 2.68 2.25-3.19 2.68 2.25-3.19 2.3 2.01-2.62 2.3 2.01-2.62 2.06 1.88-2.25 2.06 1.88-2.25 1.98 1.85-2.13 1.98 1.85-2.13 1.8 1.71-1.9 1.8 1.71-1.9 1.22 1.11-1.32 9.65e-06 1.66 1.53-1.8 1.83e-34 2.33 2.16-2.52 2.18e-102 TRUE FALSE FALSE TRUE Female 6242 62289 GRCh37/hg19 P<=5e-08 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000526/ScoringFiles/ phewas/PRSWEB_PHECODE174.1_iCOGS-ER-positive-BRCA_P_5e-08_UKB_20200608/all.tsv phewas/PRSWEB_PHECODE174.1_iCOGS-ER-positive-BRCA_P_5e-08_UKB_20200608/exclusion.tsv 2020-06-08 prsweb-phecode174-1-icogs-overall-brca-p-5e-08-ukb-20200608 prsweb-phecode174-1-icogs-overall-brca-p-5e-08-ukb-20200608 PRSWEB_PHECODE174.1_iCOGS-Overall-BRCA_P_5e-08_UKB_20200608 P_5e-08 PRSWEB_PHECODE174.1_iCOGS-Overall-BRCA_P_5e-08_UKB_20200608 174.1 Breast cancer [female], Overall Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). UKB UK Biobank GWAS Hits Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 110 3.8e-170 0.0299344 0.0818 0.601 0.594-0.608 OR 2.5 2.09-2.99 2.5 2.09-2.99 2.38 2.09-2.72 2.38 2.09-2.72 2.12 1.94-2.32 2.12 1.94-2.32 2.04 1.9-2.18 2.04 1.9-2.18 1.87 1.77-1.98 1.87 1.77-1.98 1.27 1.17-1.39 5.04e-08 1.72 1.59-1.87 3.06e-38 2.49 2.3-2.69 2.23e-116 TRUE FALSE FALSE TRUE Female 6242 62289 GRCh37/hg19 P<=5e-08 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000534/ScoringFiles/ phewas/PRSWEB_PHECODE174.1_iCOGS-Overall-BRCA_P_5e-08_UKB_20200608/all.tsv phewas/PRSWEB_PHECODE174.1_iCOGS-Overall-BRCA_P_5e-08_UKB_20200608/exclusion.tsv 2020-06-08 prsweb-phecode174-1-gwas-catalog-r2019-05-03-x174-1-pt-ukb-20200608 prsweb-phecode174-1-gwas-catalog-r2019-05-03-x174-1-pt-ukb-20200608 PRSWEB_PHECODE174.1_GWAS-Catalog-r2019-05-03-X174.1_PT_UKB_20200608 P&T PRSWEB_PHECODE174.1_GWAS-Catalog-r2019-05-03-X174.1_PT_UKB_20200608 174.1 Breast cancer;Breast cancer (estrogen-receptor negative);Breast Cancer in BRCA1 mutation carriers;Breast cancer in BRCA2 mutation carriers Binary 136 unique SNPs UKB UK Biobank P&T GWAS Catalog (2019-05-03) 17529967;17529973;17529974;18326623;19330027;19330030;20453838;20852631;20872241;21263130;21424380;23354978;23535729;23535733;23544012;23544013;25751625;29058716;29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=17529967+17529973+17529974+18326623+19330027+19330030+20453838+20852631+20872241+21263130+21424380+23354978+23535729+23535733+23544012+23544013+25751625+29058716+29059683 79 5.7e-155 0.0279805 0.0819 0.598 0.59-0.605 OR 2.68 2.25-3.18 2.68 2.25-3.18 2.3 2.01-2.62 2.3 2.01-2.62 2.09 1.91-2.28 2.09 1.91-2.28 1.93 1.8-2.07 1.93 1.8-2.07 1.83 1.74-1.93 1.83 1.74-1.93 1.4 1.29-1.53 1.51e-14 1.69 1.56-1.84 3.07e-35 2.5 2.31-2.71 8.13e-116 TRUE FALSE FALSE TRUE Female 6242 62289 GRCh37/hg19 P<=2.51e-08 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000488/ScoringFiles/ phewas/PRSWEB_PHECODE174.1_GWAS-Catalog-r2019-05-03-X174.1_PT_UKB_20200608/all.tsv phewas/PRSWEB_PHECODE174.1_GWAS-Catalog-r2019-05-03-X174.1_PT_UKB_20200608/exclusion.tsv 2020-06-08 prsweb-phecode174-1-onco-icogs-er-negative-brca-pt-ukb-20200608 prsweb-phecode174-1-onco-icogs-er-negative-brca-pt-ukb-20200608 PRSWEB_PHECODE174.1_Onco-iCOGS-ER-negative-BRCA_PT_UKB_20200608 P&T PRSWEB_PHECODE174.1_Onco-iCOGS-ER-negative-BRCA_PT_UKB_20200608 174.1 Breast cancer [female]; ER negative Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). UKB UK Biobank P&T Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 49 8.9e-63 0.00912193 0.0824 0.559 0.551-0.566 OR 2.03 1.67-2.46 2.03 1.67-2.46 1.98 1.72-2.28 1.98 1.72-2.28 1.63 1.48-1.8 1.63 1.48-1.8 1.59 1.47-1.71 1.59 1.47-1.71 1.45 1.38-1.54 1.45 1.38-1.54 1.26 1.16-1.36 2.24e-08 1.37 1.27-1.49 3.23e-15 1.76 1.63-1.9 7.25e-49 TRUE FALSE FALSE TRUE Female 6242 62289 GRCh37/hg19 P<=5e-08 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000494/ScoringFiles/ phewas/PRSWEB_PHECODE174.1_Onco-iCOGS-ER-negative-BRCA_PT_UKB_20200608/all.tsv phewas/PRSWEB_PHECODE174.1_Onco-iCOGS-ER-negative-BRCA_PT_UKB_20200608/exclusion.tsv 2020-06-08 prsweb-phecode174-1-onco-icogs-er-positive-brca-pt-ukb-20200608 prsweb-phecode174-1-onco-icogs-er-positive-brca-pt-ukb-20200608 PRSWEB_PHECODE174.1_Onco-iCOGS-ER-positive-BRCA_PT_UKB_20200608 P&T PRSWEB_PHECODE174.1_Onco-iCOGS-ER-positive-BRCA_PT_UKB_20200608 174.1 Breast cancer [female]; ER positive Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). UKB UK Biobank P&T Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 747 1.1e-235 0.0394014 0.0814 0.621 0.614-0.628 OR 3.36 2.87-3.95 3.36 2.87-3.95 2.9 2.56-3.27 2.9 2.56-3.27 2.46 2.26-2.68 2.46 2.26-2.68 2.26 2.11-2.42 2.26 2.11-2.42 2.08 1.97-2.2 2.08 1.97-2.2 1.34 1.23-1.47 1.26e-10 1.88 1.72-2.04 1.17e-47 2.93 2.71-3.17 4.27e-153 TRUE FALSE FALSE TRUE Female 6242 62289 GRCh37/hg19 P<=2.51e-05 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000502/ScoringFiles/ phewas/PRSWEB_PHECODE174.1_Onco-iCOGS-ER-positive-BRCA_PT_UKB_20200608/all.tsv phewas/PRSWEB_PHECODE174.1_Onco-iCOGS-ER-positive-BRCA_PT_UKB_20200608/exclusion.tsv 2020-06-08 prsweb-phecode174-1-onco-icogs-overall-brca-pt-ukb-20200608 prsweb-phecode174-1-onco-icogs-overall-brca-pt-ukb-20200608 PRSWEB_PHECODE174.1_Onco-iCOGS-Overall-BRCA_PT_UKB_20200608 P&T PRSWEB_PHECODE174.1_Onco-iCOGS-Overall-BRCA_PT_UKB_20200608 174.1 Breast cancer [female], Overall Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). UKB UK Biobank P&T Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 1682 2.5e-270 0.0454844 0.0811 0.63 0.623-0.637 OR 3.32 2.83-3.9 3.32 2.83-3.9 2.96 2.62-3.34 2.96 2.62-3.34 2.57 2.36-2.8 2.57 2.36-2.8 2.44 2.29-2.61 2.44 2.29-2.61 2.18 2.07-2.3 2.18 2.07-2.3 1.58 1.44-1.74 1.2e-22 2.01 1.84-2.2 1.95e-54 3.34 3.08-3.63 5.69e-180 TRUE FALSE FALSE TRUE Female 6242 62289 GRCh37/hg19 P<=1e-04 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000510/ScoringFiles/ phewas/PRSWEB_PHECODE174.1_Onco-iCOGS-Overall-BRCA_PT_UKB_20200608/all.tsv phewas/PRSWEB_PHECODE174.1_Onco-iCOGS-Overall-BRCA_PT_UKB_20200608/exclusion.tsv 2020-06-08 prsweb-phecode174-1-icogs-er-negative-brca-pt-ukb-20200608 prsweb-phecode174-1-icogs-er-negative-brca-pt-ukb-20200608 PRSWEB_PHECODE174.1_iCOGS-ER-negative-BRCA_PT_UKB_20200608 P&T PRSWEB_PHECODE174.1_iCOGS-ER-negative-BRCA_PT_UKB_20200608 174.1 Breast cancer [female]; ER negative Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). UKB UK Biobank P&T Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 14 2.2e-44 0.00581917 0.0825 0.547 0.54-0.555 OR 1.73 1.41-2.13 1.73 1.41-2.13 1.63 1.4-1.89 1.63 1.4-1.89 1.51 1.36-1.67 1.51 1.36-1.67 1.39 1.29-1.5 1.39 1.29-1.5 1.38 1.3-1.46 1.38 1.3-1.46 1.2 1.1-1.29 1.11e-05 1.35 1.25-1.46 6.02e-14 1.63 1.51-1.76 3.48e-37 TRUE FALSE FALSE TRUE Female 6242 62289 GRCh37/hg19 P<=3.16e-07 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000522/ScoringFiles/ phewas/PRSWEB_PHECODE174.1_iCOGS-ER-negative-BRCA_PT_UKB_20200608/all.tsv phewas/PRSWEB_PHECODE174.1_iCOGS-ER-negative-BRCA_PT_UKB_20200608/exclusion.tsv 2020-06-08 prsweb-phecode174-1-icogs-er-positive-brca-pt-ukb-20200608 prsweb-phecode174-1-icogs-er-positive-brca-pt-ukb-20200608 PRSWEB_PHECODE174.1_iCOGS-ER-positive-BRCA_PT_UKB_20200608 P&T PRSWEB_PHECODE174.1_iCOGS-ER-positive-BRCA_PT_UKB_20200608 174.1 Breast cancer [female]; ER positive Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). UKB UK Biobank P&T Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 174 3.6e-169 0.0287248 0.0818 0.6 0.593-0.608 OR 2.92 2.47-3.46 2.92 2.47-3.46 2.4 2.11-2.73 2.4 2.11-2.73 2.03 1.86-2.23 2.03 1.86-2.23 1.98 1.85-2.13 1.98 1.85-2.13 1.93 1.82-2.03 1.93 1.82-2.03 1.35 1.24-1.48 8.26e-12 1.64 1.51-1.78 3.22e-31 2.57 2.37-2.77 1.54e-123 TRUE FALSE FALSE TRUE Female 6242 62289 GRCh37/hg19 P<=3.98e-06 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000530/ScoringFiles/ phewas/PRSWEB_PHECODE174.1_iCOGS-ER-positive-BRCA_PT_UKB_20200608/all.tsv phewas/PRSWEB_PHECODE174.1_iCOGS-ER-positive-BRCA_PT_UKB_20200608/exclusion.tsv 2020-06-08 prsweb-phecode174-1-icogs-overall-brca-pt-ukb-20200608 prsweb-phecode174-1-icogs-overall-brca-pt-ukb-20200608 PRSWEB_PHECODE174.1_iCOGS-Overall-BRCA_PT_UKB_20200608 P&T PRSWEB_PHECODE174.1_iCOGS-Overall-BRCA_PT_UKB_20200608 174.1 Breast cancer [female], Overall Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). UKB UK Biobank P&T Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 85 9.6e-173 0.0305568 0.0818 0.602 0.594-0.609 OR 2.78 2.34-3.3 2.78 2.34-3.3 2.45 2.15-2.78 2.45 2.15-2.78 2.09 1.91-2.28 2.09 1.91-2.28 2.03 1.89-2.17 2.03 1.89-2.17 1.88 1.78-1.99 1.88 1.78-1.99 1.29 1.18-1.4 1.77e-08 1.75 1.61-1.9 6.5e-40 2.53 2.34-2.74 8.44e-120 TRUE FALSE FALSE TRUE Female 6242 62289 GRCh37/hg19 P<=1e-08 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000538/ScoringFiles/ phewas/PRSWEB_PHECODE174.1_iCOGS-Overall-BRCA_PT_UKB_20200608/all.tsv phewas/PRSWEB_PHECODE174.1_iCOGS-Overall-BRCA_PT_UKB_20200608/exclusion.tsv 2020-06-08 prsweb-phecode174-1-onco-icogs-er-negative-brca-prs-cs-ukb-20200608 prsweb-phecode174-1-onco-icogs-er-negative-brca-prs-cs-ukb-20200608 PRSWEB_PHECODE174.1_Onco-iCOGS-ER-negative-BRCA_PRS-CS_UKB_20200608 PRS-CS PRSWEB_PHECODE174.1_Onco-iCOGS-ER-negative-BRCA_PRS-CS_UKB_20200608 174.1 Breast cancer [female]; ER negative Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). UKB UK Biobank PRS-CS Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 1120410 6e-101 0.0127814 0.0822 0.579 0.572-0.586 OR 2.34 1.95-2.82 2.34 1.95-2.82 2.13 1.86-2.45 2.13 1.86-2.45 1.84 1.67-2.02 1.84 1.67-2.02 1.72 1.6-1.85 1.72 1.6-1.85 1.65 1.56-1.74 1.65 1.56-1.74 1.25 1.15-1.35 2.15e-07 1.49 1.37-1.61 4.35e-22 2.05 1.9-2.22 1.45e-76 TRUE FALSE FALSE TRUE Female 6242 62289 GRCh37/hg19 auto https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000492/ScoringFiles/ phewas/PRSWEB_PHECODE174.1_Onco-iCOGS-ER-negative-BRCA_PRS-CS_UKB_20200608/all.tsv phewas/PRSWEB_PHECODE174.1_Onco-iCOGS-ER-negative-BRCA_PRS-CS_UKB_20200608/exclusion.tsv 2020-06-08 prsweb-phecode174-1-onco-icogs-er-positive-brca-prs-cs-ukb-20200608 prsweb-phecode174-1-onco-icogs-er-positive-brca-prs-cs-ukb-20200608 PRSWEB_PHECODE174.1_Onco-iCOGS-ER-positive-BRCA_PRS-CS_UKB_20200608 PRS-CS PRSWEB_PHECODE174.1_Onco-iCOGS-ER-positive-BRCA_PRS-CS_UKB_20200608 174.1 Breast cancer [female]; ER positive Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). UKB UK Biobank PRS-CS Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 1120410 1.1225369292536e-308 0.0496967 0.0809 0.64 0.634-0.647 OR 3.64 3.12-4.25 3.64 3.12-4.25 3.32 2.96-3.73 3.32 2.96-3.73 2.82 2.6-3.07 2.82 2.6-3.07 2.52 2.36-2.69 2.52 2.36-2.69 2.32 2.2-2.44 2.32 2.2-2.44 1.62 1.47-1.78 2.11e-23 2.21 2.02-2.41 2.6e-66 3.72 3.42-4.05 1.86e-203 TRUE FALSE FALSE TRUE Female 6242 62289 GRCh37/hg19 auto https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000500/ScoringFiles/ phewas/PRSWEB_PHECODE174.1_Onco-iCOGS-ER-positive-BRCA_PRS-CS_UKB_20200608/all.tsv phewas/PRSWEB_PHECODE174.1_Onco-iCOGS-ER-positive-BRCA_PRS-CS_UKB_20200608/exclusion.tsv 2020-06-08 prsweb-phecode174-1-onco-icogs-overall-brca-prs-cs-ukb-20200608 prsweb-phecode174-1-onco-icogs-overall-brca-prs-cs-ukb-20200608 PRSWEB_PHECODE174.1_Onco-iCOGS-Overall-BRCA_PRS-CS_UKB_20200608 PRS-CS PRSWEB_PHECODE174.1_Onco-iCOGS-Overall-BRCA_PRS-CS_UKB_20200608 174.1 Breast cancer [female], Overall Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). UKB UK Biobank PRS-CS Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 1120410 2.1e-364 0.0559815 0.0805 0.652 0.645-0.658 OR 4.38 3.79-5.07 4.38 3.79-5.07 3.53 3.15-3.95 3.53 3.15-3.95 3.08 2.84-3.33 3.08 2.84-3.33 2.86 2.68-3.04 2.86 2.68-3.04 2.42 2.29-2.55 2.42 2.29-2.55 1.66 1.51-1.83 1.68e-24 2.37 2.16-2.6 7.59e-76 4.05 3.71-4.41 5.72e-221 TRUE FALSE FALSE TRUE Female 6242 62289 GRCh37/hg19 auto https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000508/ScoringFiles/ phewas/PRSWEB_PHECODE174.1_Onco-iCOGS-Overall-BRCA_PRS-CS_UKB_20200608/all.tsv phewas/PRSWEB_PHECODE174.1_Onco-iCOGS-Overall-BRCA_PRS-CS_UKB_20200608/exclusion.tsv 2020-06-08 prsweb-phecode174-1-icogs-er-negative-brca-prs-cs-ukb-20200608 prsweb-phecode174-1-icogs-er-negative-brca-prs-cs-ukb-20200608 PRSWEB_PHECODE174.1_iCOGS-ER-negative-BRCA_PRS-CS_UKB_20200608 PRS-CS PRSWEB_PHECODE174.1_iCOGS-ER-negative-BRCA_PRS-CS_UKB_20200608 174.1 Breast cancer [female]; ER negative Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). UKB UK Biobank PRS-CS Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 1116435 2.1e-38 0.00307076 0.0826 0.549 0.542-0.556 OR 1.82 1.48-2.22 1.82 1.48-2.22 1.66 1.43-1.93 1.66 1.43-1.93 1.43 1.29-1.58 1.43 1.29-1.58 1.43 1.32-1.54 1.43 1.32-1.54 1.34 1.27-1.42 1.34 1.27-1.42 1.21 1.12-1.31 2.41e-06 1.28 1.18-1.38 8.44e-10 1.56 1.45-1.68 2.23e-31 TRUE FALSE FALSE TRUE Female 6242 62289 GRCh37/hg19 auto https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000520/ScoringFiles/ phewas/PRSWEB_PHECODE174.1_iCOGS-ER-negative-BRCA_PRS-CS_UKB_20200608/all.tsv phewas/PRSWEB_PHECODE174.1_iCOGS-ER-negative-BRCA_PRS-CS_UKB_20200608/exclusion.tsv 2020-06-08 prsweb-phecode174-1-icogs-er-positive-brca-prs-cs-ukb-20200608 prsweb-phecode174-1-icogs-er-positive-brca-prs-cs-ukb-20200608 PRSWEB_PHECODE174.1_iCOGS-ER-positive-BRCA_PRS-CS_UKB_20200608 PRS-CS PRSWEB_PHECODE174.1_iCOGS-ER-positive-BRCA_PRS-CS_UKB_20200608 174.1 Breast cancer [female]; ER positive Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). UKB UK Biobank PRS-CS Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 1116495 3.3e-205 0.0308854 0.0816 0.614 0.607-0.62 OR 2.98 2.52-3.52 2.98 2.52-3.52 2.68 2.37-3.04 2.68 2.37-3.04 2.3 2.11-2.51 2.3 2.11-2.51 2.11 1.97-2.26 2.11 1.97-2.26 1.96 1.86-2.07 1.96 1.86-2.07 1.4 1.28-1.53 2.28e-13 1.89 1.74-2.06 1.93e-49 2.8 2.58-3.03 8.95e-140 TRUE FALSE FALSE TRUE Female 6242 62289 GRCh37/hg19 auto https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000528/ScoringFiles/ phewas/PRSWEB_PHECODE174.1_iCOGS-ER-positive-BRCA_PRS-CS_UKB_20200608/all.tsv phewas/PRSWEB_PHECODE174.1_iCOGS-ER-positive-BRCA_PRS-CS_UKB_20200608/exclusion.tsv 2020-06-08 prsweb-phecode174-1-icogs-overall-brca-prs-cs-ukb-20200608 prsweb-phecode174-1-icogs-overall-brca-prs-cs-ukb-20200608 PRSWEB_PHECODE174.1_iCOGS-Overall-BRCA_PRS-CS_UKB_20200608 PRS-CS PRSWEB_PHECODE174.1_iCOGS-Overall-BRCA_PRS-CS_UKB_20200608 174.1 Breast cancer [female], Overall Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). UKB UK Biobank PRS-CS Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 1116546 5.8e-243 0.0371435 0.0813 0.623 0.615-0.63 OR 3.54 3.02-4.14 3.54 3.02-4.14 3.09 2.74-3.48 3.09 2.74-3.48 2.52 2.31-2.74 2.52 2.31-2.74 2.31 2.16-2.47 2.31 2.16-2.47 2.07 1.96-2.18 2.07 1.96-2.18 1.5 1.37-1.64 3.16e-18 1.95 1.79-2.13 4.77e-52 3.07 2.83-3.33 1.03e-160 TRUE FALSE FALSE TRUE Female 6242 62289 GRCh37/hg19 auto https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000536/ScoringFiles/ phewas/PRSWEB_PHECODE174.1_iCOGS-Overall-BRCA_PRS-CS_UKB_20200608/all.tsv phewas/PRSWEB_PHECODE174.1_iCOGS-Overall-BRCA_PRS-CS_UKB_20200608/exclusion.tsv 2020-06-08 prsweb-phecode174-1-onco-icogs-er-negative-brca-lassosum-ukb-20200608 prsweb-phecode174-1-onco-icogs-er-negative-brca-lassosum-ukb-20200608 PRSWEB_PHECODE174.1_Onco-iCOGS-ER-negative-BRCA_LASSOSUM_UKB_20200608 Lassosum PRSWEB_PHECODE174.1_Onco-iCOGS-ER-negative-BRCA_LASSOSUM_UKB_20200608 174.1 Breast cancer [female]; ER negative Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). UKB UK Biobank lassosum Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 41744 3e-98 0.0129908 0.0822 0.576 0.568-0.583 OR 2.25 1.86-2.71 2.25 1.86-2.71 2.1 1.83-2.41 2.1 1.83-2.41 1.92 1.75-2.11 1.92 1.75-2.11 1.69 1.58-1.82 1.69 1.58-1.82 1.59 1.5-1.68 1.59 1.5-1.68 1.28 1.18-1.39 7.35e-09 1.54 1.42-1.67 6.88e-26 2.02 1.87-2.18 3.72e-72 TRUE FALSE FALSE TRUE Female 6242 62289 GRCh37/hg19 s=0.9;Lambda=0.006952 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000496/ScoringFiles/ phewas/PRSWEB_PHECODE174.1_Onco-iCOGS-ER-negative-BRCA_LASSOSUM_UKB_20200608/all.tsv phewas/PRSWEB_PHECODE174.1_Onco-iCOGS-ER-negative-BRCA_LASSOSUM_UKB_20200608/exclusion.tsv 2020-06-08 prsweb-phecode174-1-onco-icogs-er-positive-brca-lassosum-ukb-20200608 prsweb-phecode174-1-onco-icogs-er-positive-brca-lassosum-ukb-20200608 PRSWEB_PHECODE174.1_Onco-iCOGS-ER-positive-BRCA_LASSOSUM_UKB_20200608 Lassosum PRSWEB_PHECODE174.1_Onco-iCOGS-ER-positive-BRCA_LASSOSUM_UKB_20200608 174.1 Breast cancer [female]; ER positive Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). UKB UK Biobank lassosum Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 148560 1.4e-274 0.044924 0.0811 0.631 0.624-0.638 OR 3.86 3.31-4.5 3.86 3.31-4.5 3.22 2.87-3.63 3.22 2.87-3.63 2.67 2.45-2.9 2.67 2.45-2.9 2.46 2.3-2.62 2.46 2.3-2.62 2.2 2.09-2.32 2.2 2.09-2.32 1.56 1.43-1.72 2.04e-21 2.04 1.86-2.22 5.17e-56 3.37 3.1-3.66 4.89e-182 TRUE FALSE FALSE TRUE Female 6242 62289 GRCh37/hg19 s=0.9;Lambda=0.008859 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000504/ScoringFiles/ phewas/PRSWEB_PHECODE174.1_Onco-iCOGS-ER-positive-BRCA_LASSOSUM_UKB_20200608/all.tsv phewas/PRSWEB_PHECODE174.1_Onco-iCOGS-ER-positive-BRCA_LASSOSUM_UKB_20200608/exclusion.tsv 2020-06-08 prsweb-phecode174-1-onco-icogs-overall-brca-lassosum-ukb-20200608 prsweb-phecode174-1-onco-icogs-overall-brca-lassosum-ukb-20200608 PRSWEB_PHECODE174.1_Onco-iCOGS-Overall-BRCA_LASSOSUM_UKB_20200608 Lassosum PRSWEB_PHECODE174.1_Onco-iCOGS-Overall-BRCA_LASSOSUM_UKB_20200608 174.1 Breast cancer [female], Overall Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). UKB UK Biobank lassosum Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 286144 2.91e-325 0.0514329 0.0807 0.643 0.637-0.65 OR 4.02 3.46-4.67 4.02 3.46-4.67 3.44 3.07-3.86 3.44 3.07-3.86 2.86 2.63-3.1 2.86 2.63-3.1 2.7 2.53-2.88 2.7 2.53-2.88 2.36 2.24-2.49 2.36 2.24-2.49 1.6 1.46-1.76 2.22e-22 2.16 1.98-2.37 7.26e-63 3.75 3.45-4.08 4.69e-207 TRUE FALSE FALSE TRUE Female 6242 62289 GRCh37/hg19 s=0.9;Lambda=0.004281 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000512/ScoringFiles/ phewas/PRSWEB_PHECODE174.1_Onco-iCOGS-Overall-BRCA_LASSOSUM_UKB_20200608/all.tsv phewas/PRSWEB_PHECODE174.1_Onco-iCOGS-Overall-BRCA_LASSOSUM_UKB_20200608/exclusion.tsv 2020-06-08 prsweb-phecode174-1-icogs-er-negative-brca-lassosum-ukb-20200608 prsweb-phecode174-1-icogs-er-negative-brca-lassosum-ukb-20200608 PRSWEB_PHECODE174.1_iCOGS-ER-negative-BRCA_LASSOSUM_UKB_20200608 Lassosum PRSWEB_PHECODE174.1_iCOGS-ER-negative-BRCA_LASSOSUM_UKB_20200608 174.1 Breast cancer [female]; ER negative Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). UKB UK Biobank lassosum Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 2708 9.9e-44 0.00547943 0.0825 0.547 0.54-0.555 OR 1.72 1.4-2.11 1.72 1.4-2.11 1.67 1.44-1.94 1.67 1.44-1.94 1.54 1.39-1.71 1.54 1.39-1.71 1.42 1.31-1.53 1.42 1.31-1.53 1.37 1.3-1.45 1.37 1.3-1.45 1.14 1.05-1.23 0.00156 1.31 1.21-1.41 7.04e-12 1.58 1.47-1.7 2.92e-33 TRUE FALSE FALSE TRUE Female 6242 62289 GRCh37/hg19 s=0.9;Lambda=0.008859 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000524/ScoringFiles/ phewas/PRSWEB_PHECODE174.1_iCOGS-ER-negative-BRCA_LASSOSUM_UKB_20200608/all.tsv phewas/PRSWEB_PHECODE174.1_iCOGS-ER-negative-BRCA_LASSOSUM_UKB_20200608/exclusion.tsv 2020-06-08 prsweb-phecode174-1-icogs-er-positive-brca-lassosum-ukb-20200608 prsweb-phecode174-1-icogs-er-positive-brca-lassosum-ukb-20200608 PRSWEB_PHECODE174.1_iCOGS-ER-positive-BRCA_LASSOSUM_UKB_20200608 Lassosum PRSWEB_PHECODE174.1_iCOGS-ER-positive-BRCA_LASSOSUM_UKB_20200608 174.1 Breast cancer [female]; ER positive Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). UKB UK Biobank lassosum Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 12277 1.3e-194 0.0339124 0.0816 0.608 0.601-0.615 OR 3 2.54-3.54 3 2.54-3.54 2.8 2.47-3.17 2.8 2.47-3.17 2.44 2.24-2.66 2.44 2.24-2.66 2.1 1.96-2.25 2.1 1.96-2.25 1.93 1.83-2.03 1.93 1.83-2.03 1.4 1.28-1.53 5.75e-14 1.8 1.66-1.96 1.23e-42 2.7 2.49-2.92 2.61e-132 TRUE FALSE FALSE TRUE Female 6242 62289 GRCh37/hg19 s=0.5;Lambda=0.01129 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000532/ScoringFiles/ phewas/PRSWEB_PHECODE174.1_iCOGS-ER-positive-BRCA_LASSOSUM_UKB_20200608/all.tsv phewas/PRSWEB_PHECODE174.1_iCOGS-ER-positive-BRCA_LASSOSUM_UKB_20200608/exclusion.tsv 2020-06-08 prsweb-phecode174-1-icogs-overall-brca-lassosum-ukb-20200608 prsweb-phecode174-1-icogs-overall-brca-lassosum-ukb-20200608 PRSWEB_PHECODE174.1_iCOGS-Overall-BRCA_LASSOSUM_UKB_20200608 Lassosum PRSWEB_PHECODE174.1_iCOGS-Overall-BRCA_LASSOSUM_UKB_20200608 174.1 Breast cancer [female], Overall Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). UKB UK Biobank lassosum Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 7118 4.8e-220 0.037025 0.0814 0.615 0.607-0.622 OR 3.55 3.04-4.16 3.55 3.04-4.16 2.99 2.65-3.37 2.99 2.65-3.37 2.54 2.34-2.77 2.54 2.34-2.77 2.23 2.08-2.38 2.23 2.08-2.38 1.98 1.88-2.09 1.98 1.88-2.09 1.47 1.35-1.61 2.16e-17 1.93 1.77-2.1 5.14e-51 2.9 2.68-3.15 2.33e-147 TRUE FALSE FALSE TRUE Female 6242 62289 GRCh37/hg19 s=0.5;Lambda=0.006952 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000540/ScoringFiles/ phewas/PRSWEB_PHECODE174.1_iCOGS-Overall-BRCA_LASSOSUM_UKB_20200608/all.tsv phewas/PRSWEB_PHECODE174.1_iCOGS-Overall-BRCA_LASSOSUM_UKB_20200608/exclusion.tsv 2020-06-08 prsweb-phecode180-ukbb-saige-hrc-x180-prs-cs-mgi-20200608 prsweb-phecode180-ukbb-saige-hrc-x180-prs-cs-mgi-20200608 PRSWEB_PHECODE180_UKBB-SAIGE-HRC-X180_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE180_UKBB-SAIGE-HRC-X180_PRS-CS_MGI_20200608 180 Cervical cancer and dysplasia Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative PRS-CS UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1119236 0.074 0.000309439 0.0908 0.525 0.501-0.55 OR 0.767 0.289-2.03 0.767 0.289-2.03 0.643 0.304-1.36 0.643 0.304-1.36 1.08 0.737-1.58 1.08 0.737-1.58 1.09 0.825-1.43 1.09 0.825-1.43 1.17 0.97-1.42 1.17 0.97-1.42 0.938 0.726-1.21 0.624 1.23 0.968-1.57 0.0896 1.24 0.971-1.57 0.0852 FALSE FALSE FALSE FALSE Female 585 5192 GRCh37/hg19 auto 2020-06-08 prsweb-phecode180-ukbb-saige-hrc-x180-lassosum-mgi-20200608 prsweb-phecode180-ukbb-saige-hrc-x180-lassosum-mgi-20200608 PRSWEB_PHECODE180_UKBB-SAIGE-HRC-X180_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE180_UKBB-SAIGE-HRC-X180_LASSOSUM_MGI_20200608 180 Cervical cancer and dysplasia Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative lassosum UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 80 0.66 0.00209601 0.0909 0.476 0.453-0.498 OR 1.1 0.483-2.52 1.1 0.483-2.52 1.24 0.712-2.17 1.24 0.712-2.17 1.12 0.768-1.63 1.12 0.768-1.63 0.888 0.66-1.2 0.888 0.66-1.2 1.01 0.832-1.23 1.01 0.832-1.23 1.06 0.831-1.36 0.628 1.16 0.911-1.48 0.228 1.08 0.849-1.39 0.515 FALSE FALSE FALSE FALSE Female 585 5192 GRCh37/hg19 s=1;Lambda=0.03793 2020-06-08 prsweb-phecode180-1-20001-1041-p-5e-05-mgi-20200608 prsweb-phecode180-1-20001-1041-p-5e-05-mgi-20200608 PRSWEB_PHECODE180.1_20001-1041_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE180.1_20001-1041_P_5e-05_MGI_20200608 180.1 Cancer code, self-reported: cervical cancer Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 127 0.35 4.55985e-05 0.0826 0.511 0.468-0.553 OR 2.42 0.933-6.3 2.42 0.933-6.3 1.69 0.766-3.73 1.69 0.766-3.73 2.03 1.25-3.29 2.03 1.25-3.29 1.59 1.07-2.35 1.59 1.07-2.35 1.19 0.877-1.62 1.19 0.877-1.62 1.28 0.869-1.88 0.212 0.932 0.617-1.41 0.739 1.23 0.835-1.81 0.295 FALSE FALSE FALSE FALSE Female 223 2230 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode180-1-c3-cervix-uteri-p-5e-05-mgi-20200608 prsweb-phecode180-1-c3-cervix-uteri-p-5e-05-mgi-20200608 PRSWEB_PHECODE180.1_C3-CERVIX-UTERI_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE180.1_C3-CERVIX-UTERI_P_5e-05_MGI_20200608 180.1 Malignant neoplasm of cervix uteri Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 70 0.68 0.00132243 0.0826 0.501 0.461-0.542 OR 1.05 0.276-3.98 1.05 0.276-3.98 1.42 0.614-3.29 1.42 0.614-3.29 1.3 0.74-2.29 1.3 0.74-2.29 1.11 0.714-1.73 1.11 0.714-1.73 1.01 0.736-1.38 1.01 0.736-1.38 1.13 0.771-1.65 0.532 0.979 0.658-1.46 0.917 1.04 0.705-1.54 0.841 FALSE FALSE FALSE FALSE Female 223 2230 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode180-1-d06-p-5e-05-mgi-20200608 prsweb-phecode180-1-d06-p-5e-05-mgi-20200608 PRSWEB_PHECODE180.1_D06_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE180.1_D06_P_5e-05_MGI_20200608 180.1 Diagnoses - main ICD10: D06 Carcinoma in situ of cervix uteri Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 93 0.36 0.000189253 0.0826 0.515 0.477-0.551 OR 1.51 0.478-4.77 1.51 0.478-4.77 1.24 0.501-3.05 1.24 0.501-3.05 1.42 0.818-2.46 1.42 0.818-2.46 1.16 0.754-1.8 1.16 0.754-1.8 1.11 0.817-1.52 1.11 0.817-1.52 1.46 0.985-2.18 0.0593 1.22 0.808-1.84 0.344 1.36 0.912-2.04 0.13 FALSE FALSE FALSE FALSE Female 223 2230 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode180-1-20001-1041-p-5e-06-mgi-20200608 prsweb-phecode180-1-20001-1041-p-5e-06-mgi-20200608 PRSWEB_PHECODE180.1_20001-1041_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE180.1_20001-1041_P_5e-06_MGI_20200608 180.1 Cancer code, self-reported: cervical cancer Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 17 0.29 0.00193216 0.0826 0.511 0.471-0.549 OR 1.51 0.479-4.78 1.51 0.479-4.78 2.15 1.05-4.4 2.15 1.05-4.4 1.7 1.02-2.83 1.7 1.02-2.83 1.43 0.95-2.14 1.43 0.95-2.14 0.992 0.722-1.36 0.992 0.722-1.36 0.868 0.582-1.29 0.488 1.15 0.788-1.67 0.474 0.975 0.662-1.43 0.896 FALSE FALSE FALSE FALSE Female 223 2230 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode180-1-c3-cervix-uteri-p-5e-06-mgi-20200608 prsweb-phecode180-1-c3-cervix-uteri-p-5e-06-mgi-20200608 PRSWEB_PHECODE180.1_C3-CERVIX-UTERI_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE180.1_C3-CERVIX-UTERI_P_5e-06_MGI_20200608 180.1 Malignant neoplasm of cervix uteri Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 9 0.73 0.00135353 0.0826 0.491 0.45-0.529 OR 1.07 0.282-4.06 1.07 0.282-4.06 1.45 0.626-3.36 1.45 0.626-3.36 1.41 0.814-2.45 1.41 0.814-2.45 1.16 0.752-1.79 1.16 0.752-1.79 1.02 0.741-1.39 1.02 0.741-1.39 0.926 0.624-1.37 0.702 1.14 0.782-1.67 0.489 1 0.68-1.47 0.998 FALSE FALSE FALSE FALSE Female 223 2230 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode180-1-ukbb-saige-hrc-x180-1-p-5e-06-mgi-20200608 prsweb-phecode180-1-ukbb-saige-hrc-x180-1-p-5e-06-mgi-20200608 PRSWEB_PHECODE180.1_UKBB-SAIGE-HRC-X180.1_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE180.1_UKBB-SAIGE-HRC-X180.1_P_5e-06_MGI_20200608 180.1 Cervical cancer Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 12 0.69 0.000249693 0.0826 0.491 0.454-0.53 OR 1.04 0.273-3.93 1.04 0.273-3.93 2.58 1.32-5.04 2.58 1.32-5.04 1.29 0.734-2.28 1.29 0.734-2.28 1 0.635-1.58 1 0.635-1.58 0.985 0.717-1.35 0.985 0.717-1.35 0.968 0.655-1.43 0.872 1.11 0.756-1.62 0.601 1 0.681-1.48 0.989 FALSE FALSE FALSE FALSE Female 223 2230 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode180-1-20001-1041-p-5e-07-mgi-20200608 prsweb-phecode180-1-20001-1041-p-5e-07-mgi-20200608 PRSWEB_PHECODE180.1_20001-1041_P_5e-07_MGI_20200608 P_5e-07 PRSWEB_PHECODE180.1_20001-1041_P_5e-07_MGI_20200608 180.1 Cancer code, self-reported: cervical cancer Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-07) UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 5 0.15 0.00366029 0.0825 0.519 0.483-0.555 OR 1.52 0.48-4.8 1.52 0.48-4.8 1.67 0.756-3.68 1.67 0.756-3.68 1.42 0.817-2.46 1.42 0.817-2.46 1.01 0.641-1.6 1.01 0.641-1.6 1.25 0.92-1.69 1.25 0.92-1.69 0.891 0.598-1.33 0.57 0.971 0.657-1.43 0.882 1.19 0.816-1.73 0.368 FALSE FALSE FALSE FALSE Female 223 2230 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode180-1-20001-1041-pt-mgi-20200608 prsweb-phecode180-1-20001-1041-pt-mgi-20200608 PRSWEB_PHECODE180.1_20001-1041_PT_MGI_20200608 P&T PRSWEB_PHECODE180.1_20001-1041_PT_MGI_20200608 180.1 Cancer code, self-reported: cervical cancer Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative P&T UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 5 0.15 0.00366029 0.0825 0.519 0.483-0.555 OR 1.52 0.48-4.8 1.52 0.48-4.8 1.67 0.756-3.68 1.67 0.756-3.68 1.42 0.817-2.46 1.42 0.817-2.46 1.01 0.641-1.6 1.01 0.641-1.6 1.25 0.92-1.69 1.25 0.92-1.69 0.891 0.598-1.33 0.57 0.971 0.657-1.43 0.882 1.19 0.816-1.73 0.368 FALSE FALSE FALSE FALSE Female 223 2230 GRCh37/hg19 P<=3.16e-07 2020-06-08 prsweb-phecode180-1-c3-cervix-uteri-pt-mgi-20200608 prsweb-phecode180-1-c3-cervix-uteri-pt-mgi-20200608 PRSWEB_PHECODE180.1_C3-CERVIX-UTERI_PT_MGI_20200608 P&T PRSWEB_PHECODE180.1_C3-CERVIX-UTERI_PT_MGI_20200608 180.1 Malignant neoplasm of cervix uteri Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative P&T UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 105 0.29 0.00258711 0.0826 0.519 0.477-0.56 OR 0.622 0.116-3.34 0.622 0.116-3.34 0.757 0.251-2.28 0.757 0.251-2.28 1.3 0.736-2.28 1.3 0.736-2.28 1.26 0.827-1.92 1.26 0.827-1.92 1.24 0.915-1.68 1.24 0.915-1.68 0.927 0.618-1.39 0.714 1.11 0.75-1.64 0.605 1.26 0.865-1.85 0.226 FALSE FALSE FALSE FALSE Female 223 2230 GRCh37/hg19 P<=7.94e-05 2020-06-08 prsweb-phecode180-1-ukbb-saige-hrc-x180-1-pt-mgi-20200608 prsweb-phecode180-1-ukbb-saige-hrc-x180-1-pt-mgi-20200608 PRSWEB_PHECODE180.1_UKBB-SAIGE-HRC-X180.1_PT_MGI_20200608 P&T PRSWEB_PHECODE180.1_UKBB-SAIGE-HRC-X180.1_PT_MGI_20200608 180.1 Cervical cancer Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative P&T UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 5 0.46 0.00150093 0.0826 0.492 0.454-0.531 OR 1.04 0.273-3.95 1.04 0.273-3.95 1.19 0.484-2.94 1.19 0.484-2.94 0.926 0.484-1.77 0.926 0.484-1.77 1.46 0.981-2.19 1.46 0.981-2.19 1.06 0.776-1.45 1.06 0.776-1.45 1.15 0.777-1.7 0.486 1.12 0.757-1.67 0.566 1.16 0.785-1.72 0.454 FALSE FALSE FALSE FALSE Female 223 2230 GRCh37/hg19 P<=2.51e-06 2020-06-08 prsweb-phecode180-1-20001-1041-prs-cs-mgi-20200608 prsweb-phecode180-1-20001-1041-prs-cs-mgi-20200608 PRSWEB_PHECODE180.1_20001-1041_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE180.1_20001-1041_PRS-CS_MGI_20200608 180.1 Cancer code, self-reported: cervical cancer Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative PRS-CS UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1107375 0.97 6.7582e-05 0.0826 0.502 0.466-0.541 OR 1.46 0.46-4.6 1.46 0.46-4.6 1.87 0.881-3.96 1.87 0.881-3.96 1.1 0.605-2.01 1.1 0.605-2.01 0.807 0.492-1.32 0.807 0.492-1.32 0.958 0.696-1.32 0.958 0.696-1.32 1.15 0.785-1.69 0.472 1 0.677-1.48 0.993 0.967 0.652-1.43 0.868 FALSE FALSE FALSE FALSE Female 223 2230 GRCh37/hg19 auto 2020-06-08 prsweb-phecode180-1-c3-cervix-uteri-prs-cs-mgi-20200608 prsweb-phecode180-1-c3-cervix-uteri-prs-cs-mgi-20200608 PRSWEB_PHECODE180.1_C3-CERVIX-UTERI_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE180.1_C3-CERVIX-UTERI_PRS-CS_MGI_20200608 180.1 Malignant neoplasm of cervix uteri Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative PRS-CS UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1049464 0.74 0.00193584 0.0826 0.501 0.46-0.543 OR 1.48 0.469-4.69 1.48 0.469-4.69 2.11 1.03-4.32 2.11 1.03-4.32 1.48 0.867-2.54 1.48 0.867-2.54 1.36 0.901-2.05 1.36 0.901-2.05 1.03 0.752-1.41 1.03 0.752-1.41 0.816 0.554-1.2 0.305 0.9 0.616-1.32 0.588 0.925 0.633-1.35 0.686 FALSE FALSE FALSE FALSE Female 223 2230 GRCh37/hg19 auto 2020-06-08 prsweb-phecode180-1-c53-prs-cs-mgi-20200608 prsweb-phecode180-1-c53-prs-cs-mgi-20200608 PRSWEB_PHECODE180.1_C53_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE180.1_C53_PRS-CS_MGI_20200608 180.1 Diagnoses - main ICD10: C53 Malignant neoplasm of cervix uteri Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative PRS-CS UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 978092 0.87 0.00168684 0.0826 0.502 0.465-0.539 OR 1.06 0.278-4.01 1.06 0.278-4.01 1.21 0.49-2.98 1.21 0.49-2.98 0.924 0.483-1.77 0.924 0.483-1.77 1.05 0.673-1.65 1.05 0.673-1.65 0.983 0.716-1.35 0.983 0.716-1.35 1.18 0.792-1.76 0.415 1.28 0.871-1.89 0.206 1.13 0.758-1.68 0.551 FALSE FALSE FALSE FALSE Female 223 2230 GRCh37/hg19 auto 2020-06-08 prsweb-phecode180-1-d06-prs-cs-mgi-20200608 prsweb-phecode180-1-d06-prs-cs-mgi-20200608 PRSWEB_PHECODE180.1_D06_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE180.1_D06_PRS-CS_MGI_20200608 180.1 Diagnoses - main ICD10: D06 Carcinoma in situ of cervix uteri Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative PRS-CS UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1067182 0.33 0.000765554 0.0826 0.521 0.479-0.564 OR 1.07 0.282-4.08 1.07 0.282-4.08 1.21 0.489-2.98 1.21 0.489-2.98 1.2 0.672-2.16 1.2 0.672-2.16 1.41 0.939-2.11 1.41 0.939-2.11 1.29 0.958-1.75 1.29 0.958-1.75 1.25 0.845-1.86 0.261 1.01 0.667-1.52 0.976 1.37 0.934-2.02 0.107 FALSE FALSE FALSE FALSE Female 223 2230 GRCh37/hg19 auto 2020-06-08 prsweb-phecode180-1-ukbb-saige-hrc-x180-1-prs-cs-mgi-20200608 prsweb-phecode180-1-ukbb-saige-hrc-x180-1-prs-cs-mgi-20200608 PRSWEB_PHECODE180.1_UKBB-SAIGE-HRC-X180.1_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE180.1_UKBB-SAIGE-HRC-X180.1_PRS-CS_MGI_20200608 180.1 Cervical cancer Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative PRS-CS UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1119236 0.44 0.000443433 0.0826 0.51 0.471-0.548 OR 3.78 1.68-8.53 3.78 1.68-8.53 1.93 0.909-4.1 1.93 0.909-4.1 1.03 0.55-1.92 1.03 0.55-1.92 1.16 0.75-1.79 1.16 0.75-1.79 1.01 0.739-1.39 1.01 0.739-1.39 0.988 0.669-1.46 0.953 1.09 0.744-1.6 0.656 1.04 0.706-1.53 0.842 FALSE FALSE FALSE FALSE Female 223 2230 GRCh37/hg19 auto 2020-06-08 prsweb-phecode180-1-c3-cervix-uteri-lassosum-mgi-20200608 prsweb-phecode180-1-c3-cervix-uteri-lassosum-mgi-20200608 PRSWEB_PHECODE180.1_C3-CERVIX-UTERI_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE180.1_C3-CERVIX-UTERI_LASSOSUM_MGI_20200608 180.1 Malignant neoplasm of cervix uteri Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative lassosum UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 243546 0.069 0.00202466 0.0825 0.538 0.498-0.578 OR 1.05 0.278-4 1.05 0.278-4 0.989 0.37-2.65 0.989 0.37-2.65 1.21 0.674-2.16 1.21 0.674-2.16 1.35 0.898-2.04 1.35 0.898-2.04 1.49 1.11-2 1.49 1.11-2 1.01 0.669-1.51 0.978 1.02 0.682-1.54 0.911 1.5 1.03-2.19 0.035 FALSE FALSE FALSE FALSE Female 223 2230 GRCh37/hg19 s=0.2;Lambda=0.02336 2020-06-08 prsweb-phecode180-3-20001-1072-p-5e-05-mgi-20200608 prsweb-phecode180-3-20001-1072-p-5e-05-mgi-20200608 PRSWEB_PHECODE180.3_20001-1072_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE180.3_20001-1072_P_5e-05_MGI_20200608 180.3 Cancer code, self-reported: cin/pre-cancer cells cervix Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 132 0.084 0.000217336 0.0885 0.519 0.49-0.548 OR 1.25 0.504-3.09 1.25 0.504-3.09 1.21 0.628-2.33 1.21 0.628-2.33 0.844 0.518-1.38 0.844 0.518-1.38 1.19 0.872-1.63 1.19 0.872-1.63 1.13 0.905-1.42 1.13 0.905-1.42 1.13 0.84-1.51 0.429 1.24 0.931-1.65 0.141 1.25 0.941-1.67 0.122 FALSE FALSE FALSE FALSE Female 430 3939 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode180-3-20001-1072-p-5e-06-mgi-20200608 prsweb-phecode180-3-20001-1072-p-5e-06-mgi-20200608 PRSWEB_PHECODE180.3_20001-1072_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE180.3_20001-1072_P_5e-06_MGI_20200608 180.3 Cancer code, self-reported: cin/pre-cancer cells cervix Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 28 0.27 0.000156027 0.0885 0.503 0.475-0.533 OR 0.739 0.244-2.24 0.739 0.244-2.24 0.728 0.324-1.63 0.728 0.324-1.63 1.13 0.733-1.74 1.13 0.733-1.74 1.13 0.826-1.56 1.13 0.826-1.56 1.09 0.868-1.36 1.09 0.868-1.36 1.04 0.781-1.4 0.768 1.17 0.885-1.55 0.267 1.17 0.879-1.55 0.286 FALSE FALSE FALSE FALSE Female 430 3939 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode180-3-20001-1072-p-5e-07-mgi-20200608 prsweb-phecode180-3-20001-1072-p-5e-07-mgi-20200608 PRSWEB_PHECODE180.3_20001-1072_P_5e-07_MGI_20200608 P_5e-07 PRSWEB_PHECODE180.3_20001-1072_P_5e-07_MGI_20200608 180.3 Cancer code, self-reported: cin/pre-cancer cells cervix Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-07) UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 5 0.04 0.000575173 0.0885 0.514 0.486-0.543 OR 0.777 0.257-2.35 0.777 0.257-2.35 1.22 0.635-2.35 1.22 0.635-2.35 0.942 0.591-1.5 0.942 0.591-1.5 0.959 0.685-1.34 0.959 0.685-1.34 1.38 1.11-1.71 1.38 1.11-1.71 1.23 0.912-1.66 0.175 1.22 0.904-1.64 0.196 1.59 1.19-2.11 0.00148 TRUE FALSE FALSE FALSE Female 430 3939 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode180-3-20001-1072-pt-mgi-20200608 prsweb-phecode180-3-20001-1072-pt-mgi-20200608 PRSWEB_PHECODE180.3_20001-1072_PT_MGI_20200608 P&T PRSWEB_PHECODE180.3_20001-1072_PT_MGI_20200608 180.3 Cancer code, self-reported: cin/pre-cancer cells cervix Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative P&T UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 10 0.35 0.000792041 0.0885 0.493 0.465-0.522 OR 1.73 0.784-3.84 1.73 0.784-3.84 1.11 0.56-2.2 1.11 0.56-2.2 1.1 0.709-1.71 1.1 0.709-1.71 0.965 0.689-1.35 0.965 0.689-1.35 1.07 0.857-1.35 1.07 0.857-1.35 0.908 0.679-1.22 0.517 1.14 0.862-1.5 0.361 1.09 0.826-1.45 0.535 FALSE FALSE FALSE FALSE Female 430 3939 GRCh37/hg19 P<=1e-06 2020-06-08 prsweb-phecode180-3-20001-1072-prs-cs-mgi-20200608 prsweb-phecode180-3-20001-1072-prs-cs-mgi-20200608 PRSWEB_PHECODE180.3_20001-1072_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE180.3_20001-1072_PRS-CS_MGI_20200608 180.3 Cancer code, self-reported: cin/pre-cancer cells cervix Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative PRS-CS UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1105412 0.2 0.00389388 0.0885 0.525 0.498-0.553 OR 0.536 0.147-1.95 0.536 0.147-1.95 1.2 0.624-2.31 1.2 0.624-2.31 1.36 0.904-2.04 1.36 0.904-2.04 1.14 0.832-1.57 1.14 0.832-1.57 1.1 0.882-1.38 1.1 0.882-1.38 0.964 0.72-1.29 0.804 1.18 0.887-1.56 0.261 1.16 0.873-1.53 0.311 FALSE FALSE FALSE FALSE Female 430 3939 GRCh37/hg19 auto 2020-06-08 prsweb-phecode180-3-20001-1072-lassosum-mgi-20200608 prsweb-phecode180-3-20001-1072-lassosum-mgi-20200608 PRSWEB_PHECODE180.3_20001-1072_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE180.3_20001-1072_LASSOSUM_MGI_20200608 180.3 Cancer code, self-reported: cin/pre-cancer cells cervix Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative lassosum UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 5850633 0.17 0.00486203 0.0885 0.525 0.496-0.555 OR 0.801 0.265-2.43 0.801 0.265-2.43 1.22 0.634-2.35 1.22 0.634-2.35 1.15 0.747-1.77 1.15 0.747-1.77 1.31 0.967-1.77 1.31 0.967-1.77 1.2 0.961-1.5 1.2 0.961-1.5 0.974 0.73-1.3 0.861 1.03 0.771-1.37 0.86 1.21 0.918-1.6 0.176 FALSE FALSE FALSE FALSE Female 430 3939 GRCh37/hg19 s=1;Lambda=0.001 2020-06-08 prsweb-phecode180-3-ukbb-saige-hrc-x180-3-lassosum-mgi-20200608 prsweb-phecode180-3-ukbb-saige-hrc-x180-3-lassosum-mgi-20200608 PRSWEB_PHECODE180.3_UKBB-SAIGE-HRC-X180.3_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE180.3_UKBB-SAIGE-HRC-X180.3_LASSOSUM_MGI_20200608 180.3 Cervical intraepithelial neoplasia [CIN] [Cervical dysplasia] Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative lassosum UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 38 0.99 0.00379566 0.0886 0.519 0.49-0.549 OR 0.334 0.0641-1.74 0.334 0.0641-1.74 0.521 0.2-1.36 0.521 0.2-1.36 0.718 0.424-1.22 0.718 0.424-1.22 0.898 0.634-1.27 0.898 0.634-1.27 0.92 0.728-1.16 0.92 0.728-1.16 0.937 0.703-1.25 0.653 1.15 0.878-1.52 0.303 0.953 0.716-1.27 0.741 FALSE FALSE FALSE FALSE Female 430 3939 GRCh37/hg19 s=0.5;Lambda=0.04833 2020-06-08 prsweb-phecode182-20001-1040-p-5e-05-mgi-20200608 prsweb-phecode182-20001-1040-p-5e-05-mgi-20200608 PRSWEB_PHECODE182_20001-1040_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE182_20001-1040_P_5e-05_MGI_20200608 182 Cancer code, self-reported: uterine/endometrial cancer Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 115 0.42 0.00144011 0.0832 0.511 0.478-0.544 OR 0.722 0.196-2.66 0.722 0.196-2.66 0.516 0.174-1.53 0.516 0.174-1.53 1.07 0.647-1.78 1.07 0.647-1.78 0.92 0.624-1.36 0.92 0.624-1.36 1.11 0.859-1.43 1.11 0.859-1.43 0.945 0.678-1.32 0.736 1.12 0.817-1.54 0.474 1.12 0.814-1.54 0.488 FALSE FALSE FALSE FALSE Female 327 3240 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode182-c3-corpus-uteri-p-5e-05-mgi-20200608 prsweb-phecode182-c3-corpus-uteri-p-5e-05-mgi-20200608 PRSWEB_PHECODE182_C3-CORPUS-UTERI_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE182_C3-CORPUS-UTERI_P_5e-05_MGI_20200608 182 Malignant neoplasm of corpus uteri Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 134 0.68 0.00016901 0.0832 0.498 0.465-0.529 OR 1.32 0.484-3.59 1.32 0.484-3.59 1.13 0.522-2.43 1.13 0.522-2.43 1.47 0.938-2.3 1.47 0.938-2.3 1.2 0.842-1.71 1.2 0.842-1.71 0.948 0.727-1.24 0.948 0.727-1.24 0.969 0.701-1.34 0.848 1.08 0.789-1.48 0.628 0.959 0.694-1.32 0.799 FALSE FALSE FALSE FALSE Female 327 3240 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode182-c54-p-5e-05-mgi-20200608 prsweb-phecode182-c54-p-5e-05-mgi-20200608 PRSWEB_PHECODE182_C54_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE182_C54_P_5e-05_MGI_20200608 182 Diagnoses - main ICD10: C54 Malignant neoplasm of corpus uteri Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 123 0.21 0.000125805 0.0832 0.514 0.485-0.547 OR 0.739 0.2-2.72 0.739 0.2-2.72 1.14 0.527-2.45 1.14 0.527-2.45 1.27 0.789-2.04 1.27 0.789-2.04 1.24 0.872-1.76 1.24 0.872-1.76 1.16 0.903-1.5 1.16 0.903-1.5 1.42 1.03-1.96 0.0317 0.999 0.707-1.41 0.994 1.32 0.951-1.83 0.0974 FALSE FALSE FALSE FALSE Female 327 3240 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode182-gwas-catalog-r2019-05-03-x182-p-5e-05-mgi-20200608 prsweb-phecode182-gwas-catalog-r2019-05-03-x182-p-5e-05-mgi-20200608 PRSWEB_PHECODE182_GWAS-Catalog-r2019-05-03-X182_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE182_GWAS-Catalog-r2019-05-03-X182_P_5e-05_MGI_20200608 182 Endometrial cancer;Endometrial cancer (endometrioid histology);Endometrial endometrioid carcinoma;Endometrial cancer (Non-endometrioid histology) Binary 37 unique SNPs MGI Michigan Genomics Initiative Fixed threshold (5e-05) GWAS Catalog (2019-05-03) 21499250;27135401;30093612 https://www.ncbi.nlm.nih.gov/pubmed/?term=21499250+27135401+30093612 34 0.13 0.00191496 0.0832 0.516 0.482-0.547 OR 1.04 0.339-3.19 1.04 0.339-3.19 1.45 0.722-2.89 1.45 0.722-2.89 1.19 0.734-1.94 1.19 0.734-1.94 1.37 0.974-1.92 1.37 0.974-1.92 1.06 0.816-1.37 1.06 0.816-1.37 1.26 0.912-1.74 0.16 1.1 0.793-1.54 0.559 1.17 0.846-1.63 0.337 FALSE FALSE FALSE FALSE Female 327 3240 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode182-c3-corpus-uteri-p-5e-06-mgi-20200608 prsweb-phecode182-c3-corpus-uteri-p-5e-06-mgi-20200608 PRSWEB_PHECODE182_C3-CORPUS-UTERI_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE182_C3-CORPUS-UTERI_P_5e-06_MGI_20200608 182 Malignant neoplasm of corpus uteri Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 17 0.71 5.96881e-05 0.0832 0.48 0.449-0.511 OR 0.444 0.0845-2.33 0.444 0.0845-2.33 1.3 0.626-2.68 1.3 0.626-2.68 1.13 0.688-1.85 1.13 0.688-1.85 0.859 0.575-1.28 0.859 0.575-1.28 1.03 0.792-1.33 1.03 0.792-1.33 1.23 0.893-1.7 0.204 1.14 0.822-1.59 0.429 1.17 0.842-1.62 0.351 FALSE FALSE FALSE FALSE Female 327 3240 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode182-c54-p-5e-06-mgi-20200608 prsweb-phecode182-c54-p-5e-06-mgi-20200608 PRSWEB_PHECODE182_C54_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE182_C54_P_5e-06_MGI_20200608 182 Diagnoses - main ICD10: C54 Malignant neoplasm of corpus uteri Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 20 0.69 0.00195113 0.0832 0.493 0.461-0.524 OR 1.64 0.654-4.11 1.64 0.654-4.11 1.29 0.625-2.67 1.29 0.625-2.67 1.01 0.602-1.7 1.01 0.602-1.7 0.763 0.501-1.16 0.763 0.501-1.16 1.03 0.794-1.34 1.03 0.794-1.34 0.863 0.621-1.2 0.378 1.07 0.785-1.47 0.652 1.01 0.737-1.39 0.936 FALSE FALSE FALSE FALSE Female 327 3240 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode182-gwas-catalog-r2019-05-03-x182-p-5e-06-mgi-20200608 prsweb-phecode182-gwas-catalog-r2019-05-03-x182-p-5e-06-mgi-20200608 PRSWEB_PHECODE182_GWAS-Catalog-r2019-05-03-X182_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE182_GWAS-Catalog-r2019-05-03-X182_P_5e-06_MGI_20200608 182 Endometrial cancer;Endometrial cancer (endometrioid histology);Endometrial endometrioid carcinoma;Endometrial cancer (Non-endometrioid histology) Binary 37 unique SNPs MGI Michigan Genomics Initiative Fixed threshold (5e-06) GWAS Catalog (2019-05-03) 21499250;27135401;30093612 https://www.ncbi.nlm.nih.gov/pubmed/?term=21499250+27135401+30093612 34 0.13 0.00191496 0.0832 0.516 0.482-0.547 OR 1.04 0.339-3.19 1.04 0.339-3.19 1.45 0.722-2.89 1.45 0.722-2.89 1.19 0.734-1.94 1.19 0.734-1.94 1.37 0.974-1.92 1.37 0.974-1.92 1.06 0.816-1.37 1.06 0.816-1.37 1.26 0.912-1.74 0.16 1.1 0.793-1.54 0.559 1.17 0.846-1.63 0.337 FALSE FALSE FALSE FALSE Female 327 3240 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode182-ukbb-saige-hrc-x182-p-5e-06-mgi-20200608 prsweb-phecode182-ukbb-saige-hrc-x182-p-5e-06-mgi-20200608 PRSWEB_PHECODE182_UKBB-SAIGE-HRC-X182_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE182_UKBB-SAIGE-HRC-X182_P_5e-06_MGI_20200608 182 Malignant neoplasm of uterus Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 10 0.4 0.000801517 0.0832 0.51 0.478-0.542 OR 0.736 0.2-2.71 0.736 0.2-2.71 0.679 0.259-1.78 0.679 0.259-1.78 0.945 0.554-1.61 0.945 0.554-1.61 0.995 0.68-1.45 0.995 0.68-1.45 1.1 0.849-1.42 1.1 0.849-1.42 1.06 0.76-1.47 0.741 1.17 0.847-1.61 0.342 1.16 0.838-1.6 0.373 FALSE FALSE FALSE FALSE Female 327 3240 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode182-gwas-catalog-r2019-05-03-x182-p-5e-07-mgi-20200608 prsweb-phecode182-gwas-catalog-r2019-05-03-x182-p-5e-07-mgi-20200608 PRSWEB_PHECODE182_GWAS-Catalog-r2019-05-03-X182_P_5e-07_MGI_20200608 P_5e-07 PRSWEB_PHECODE182_GWAS-Catalog-r2019-05-03-X182_P_5e-07_MGI_20200608 182 Endometrial cancer;Endometrial cancer (endometrioid histology);Endometrial endometrioid carcinoma;Endometrial cancer (Non-endometrioid histology) Binary 37 unique SNPs MGI Michigan Genomics Initiative Fixed threshold (5e-07) GWAS Catalog (2019-05-03) 21499250;27135401;30093612 https://www.ncbi.nlm.nih.gov/pubmed/?term=21499250+27135401+30093612 28 0.1 0.00343738 0.0832 0.523 0.49-0.556 OR 1.96 0.831-4.63 1.96 0.831-4.63 1.6 0.822-3.11 1.6 0.822-3.11 1.25 0.78-2.02 1.25 0.78-2.02 1.06 0.73-1.53 1.06 0.73-1.53 1.16 0.9-1.5 1.16 0.9-1.5 1.12 0.804-1.57 0.498 1.2 0.868-1.67 0.266 1.28 0.922-1.77 0.141 FALSE FALSE FALSE FALSE Female 327 3240 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode182-gwas-catalog-r2019-05-03-x182-p-5e-09-mgi-20200608 prsweb-phecode182-gwas-catalog-r2019-05-03-x182-p-5e-09-mgi-20200608 PRSWEB_PHECODE182_GWAS-Catalog-r2019-05-03-X182_P_5e-09_MGI_20200608 P_5e-09 PRSWEB_PHECODE182_GWAS-Catalog-r2019-05-03-X182_P_5e-09_MGI_20200608 182 Endometrial cancer;Endometrial cancer (endometrioid histology);Endometrial endometrioid carcinoma;Endometrial cancer (Non-endometrioid histology) Binary 37 unique SNPs MGI Michigan Genomics Initiative Fixed threshold (5e-09) GWAS Catalog (2019-05-03) 21499250;27135401;30093612 https://www.ncbi.nlm.nih.gov/pubmed/?term=21499250+27135401+30093612 11 0.03 0.00251128 0.0831 0.532 0.501-0.565 OR 1.33 0.49-3.63 1.33 0.49-3.63 1.14 0.53-2.46 1.14 0.53-2.46 2.03 1.36-3.04 2.03 1.36-3.04 1.42 1.01-1.99 1.42 1.01-1.99 1.15 0.888-1.48 1.15 0.888-1.48 1.29 0.917-1.8 0.145 1.35 0.97-1.89 0.0753 1.38 0.991-1.93 0.0564 TRUE FALSE FALSE FALSE Female 327 3240 GRCh37/hg19 P<=5e-09 2020-06-08 prsweb-phecode182-gwas-catalog-r2019-05-03-x182-p-5e-08-mgi-20200608 prsweb-phecode182-gwas-catalog-r2019-05-03-x182-p-5e-08-mgi-20200608 PRSWEB_PHECODE182_GWAS-Catalog-r2019-05-03-X182_P_5e-08_MGI_20200608 P_5e-08 PRSWEB_PHECODE182_GWAS-Catalog-r2019-05-03-X182_P_5e-08_MGI_20200608 182 Endometrial cancer;Endometrial cancer (endometrioid histology);Endometrial endometrioid carcinoma;Endometrial cancer (Non-endometrioid histology) Binary 37 unique SNPs MGI Michigan Genomics Initiative GWAS Hits GWAS Catalog (2019-05-03) 21499250;27135401;30093612 https://www.ncbi.nlm.nih.gov/pubmed/?term=21499250+27135401+30093612 18 0.061 0.0026884 0.0832 0.531 0.497-0.564 OR 1.94 0.823-4.57 1.94 0.823-4.57 1.13 0.525-2.44 1.13 0.525-2.44 1.33 0.837-2.12 1.33 0.837-2.12 1.16 0.812-1.67 1.16 0.812-1.67 1.22 0.946-1.57 1.22 0.946-1.57 1.35 0.962-1.89 0.0831 1.33 0.951-1.87 0.0957 1.5 1.07-2.09 0.0179 FALSE FALSE FALSE FALSE Female 327 3240 GRCh37/hg19 P<=5e-08 2020-06-08 prsweb-phecode182-20001-1040-pt-mgi-20200608 prsweb-phecode182-20001-1040-pt-mgi-20200608 PRSWEB_PHECODE182_20001-1040_PT_MGI_20200608 P&T PRSWEB_PHECODE182_20001-1040_PT_MGI_20200608 182 Cancer code, self-reported: uterine/endometrial cancer Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative P&T UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 115 0.42 0.00144011 0.0832 0.511 0.478-0.544 OR 0.722 0.196-2.66 0.722 0.196-2.66 0.516 0.174-1.53 0.516 0.174-1.53 1.07 0.647-1.78 1.07 0.647-1.78 0.92 0.624-1.36 0.92 0.624-1.36 1.11 0.859-1.43 1.11 0.859-1.43 0.945 0.678-1.32 0.736 1.12 0.817-1.54 0.474 1.12 0.814-1.54 0.488 FALSE FALSE FALSE FALSE Female 327 3240 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode182-c54-pt-mgi-20200608 prsweb-phecode182-c54-pt-mgi-20200608 PRSWEB_PHECODE182_C54_PT_MGI_20200608 P&T PRSWEB_PHECODE182_C54_PT_MGI_20200608 182 Diagnoses - main ICD10: C54 Malignant neoplasm of corpus uteri Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative P&T UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 20 0.69 0.00195113 0.0832 0.493 0.461-0.524 OR 1.64 0.654-4.11 1.64 0.654-4.11 1.29 0.625-2.67 1.29 0.625-2.67 1.01 0.602-1.7 1.01 0.602-1.7 0.763 0.501-1.16 0.763 0.501-1.16 1.03 0.794-1.34 1.03 0.794-1.34 0.863 0.621-1.2 0.378 1.07 0.785-1.47 0.652 1.01 0.737-1.39 0.936 FALSE FALSE FALSE FALSE Female 327 3240 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode182-gwas-catalog-r2019-05-03-x182-pt-mgi-20200608 prsweb-phecode182-gwas-catalog-r2019-05-03-x182-pt-mgi-20200608 PRSWEB_PHECODE182_GWAS-Catalog-r2019-05-03-X182_PT_MGI_20200608 P&T PRSWEB_PHECODE182_GWAS-Catalog-r2019-05-03-X182_PT_MGI_20200608 182 Endometrial cancer;Endometrial cancer (endometrioid histology);Endometrial endometrioid carcinoma;Endometrial cancer (Non-endometrioid histology) Binary 37 unique SNPs MGI Michigan Genomics Initiative P&T GWAS Catalog (2019-05-03) 21499250;27135401;30093612 https://www.ncbi.nlm.nih.gov/pubmed/?term=21499250+27135401+30093612 31 0.081 0.00485782 0.0832 0.521 0.49-0.551 OR 1.04 0.34-3.19 1.04 0.34-3.19 1.31 0.631-2.7 1.31 0.631-2.7 1.32 0.828-2.1 1.32 0.828-2.1 1.16 0.811-1.66 1.16 0.811-1.66 1.04 0.801-1.35 1.04 0.801-1.35 1.24 0.884-1.73 0.215 1.41 1.02-1.96 0.0378 1.27 0.911-1.78 0.157 FALSE FALSE FALSE FALSE Female 327 3240 GRCh37/hg19 P<=6.31e-07 2020-06-08 prsweb-phecode182-ukbb-saige-hrc-x182-pt-mgi-20200608 prsweb-phecode182-ukbb-saige-hrc-x182-pt-mgi-20200608 PRSWEB_PHECODE182_UKBB-SAIGE-HRC-X182_PT_MGI_20200608 P&T PRSWEB_PHECODE182_UKBB-SAIGE-HRC-X182_PT_MGI_20200608 182 Malignant neoplasm of uterus Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative P&T UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 28 0.82 0.00429245 0.0832 0.49 0.458-0.522 OR 0.729 0.198-2.69 0.729 0.198-2.69 0.986 0.435-2.23 0.986 0.435-2.23 0.944 0.553-1.61 0.944 0.553-1.61 0.994 0.68-1.45 0.994 0.68-1.45 0.916 0.701-1.2 0.916 0.701-1.2 1.07 0.772-1.48 0.686 1.23 0.899-1.69 0.193 1.01 0.726-1.41 0.951 FALSE FALSE FALSE FALSE Female 327 3240 GRCh37/hg19 P<=1.26e-05 2020-06-08 prsweb-phecode182-20001-1040-prs-cs-mgi-20200608 prsweb-phecode182-20001-1040-prs-cs-mgi-20200608 PRSWEB_PHECODE182_20001-1040_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE182_20001-1040_PRS-CS_MGI_20200608 182 Cancer code, self-reported: uterine/endometrial cancer Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative PRS-CS UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1097611 0.49 1.53475e-05 0.0832 0.508 0.475-0.539 OR 1.03 0.335-3.14 1.03 0.335-3.14 0.832 0.344-2.01 0.832 0.344-2.01 1.2 0.738-1.94 1.2 0.738-1.94 1.19 0.837-1.7 1.19 0.837-1.7 0.978 0.751-1.27 0.978 0.751-1.27 1.02 0.736-1.41 0.91 1.16 0.847-1.6 0.35 1.04 0.75-1.44 0.823 FALSE FALSE FALSE FALSE Female 327 3240 GRCh37/hg19 auto 2020-06-08 prsweb-phecode182-c3-corpus-uteri-prs-cs-mgi-20200608 prsweb-phecode182-c3-corpus-uteri-prs-cs-mgi-20200608 PRSWEB_PHECODE182_C3-CORPUS-UTERI_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE182_C3-CORPUS-UTERI_PRS-CS_MGI_20200608 182 Malignant neoplasm of corpus uteri Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative PRS-CS UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1104808 0.64 0.000147022 0.0832 0.506 0.472-0.537 OR 0.733 0.199-2.7 0.733 0.199-2.7 0.521 0.176-1.54 0.521 0.176-1.54 0.684 0.372-1.26 0.684 0.372-1.26 0.786 0.52-1.19 0.786 0.52-1.19 0.993 0.764-1.29 0.993 0.764-1.29 1.02 0.739-1.41 0.896 1.1 0.799-1.51 0.562 1.02 0.736-1.4 0.922 FALSE FALSE FALSE FALSE Female 327 3240 GRCh37/hg19 auto 2020-06-08 prsweb-phecode182-c54-prs-cs-mgi-20200608 prsweb-phecode182-c54-prs-cs-mgi-20200608 PRSWEB_PHECODE182_C54_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE182_C54_PRS-CS_MGI_20200608 182 Diagnoses - main ICD10: C54 Malignant neoplasm of corpus uteri Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative PRS-CS UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1101394 0.27 0.000370966 0.0832 0.516 0.482-0.543 OR 0.727 0.197-2.68 0.727 0.197-2.68 0.817 0.339-1.97 0.817 0.339-1.97 1 0.594-1.68 1 0.594-1.68 0.956 0.651-1.4 0.956 0.651-1.4 0.977 0.751-1.27 0.977 0.751-1.27 1.36 0.975-1.89 0.0701 1.42 1.02-1.98 0.0359 1.24 0.882-1.74 0.217 FALSE FALSE FALSE FALSE Female 327 3240 GRCh37/hg19 auto 2020-06-08 prsweb-phecode182-ukbb-saige-hrc-x182-prs-cs-mgi-20200608 prsweb-phecode182-ukbb-saige-hrc-x182-prs-cs-mgi-20200608 PRSWEB_PHECODE182_UKBB-SAIGE-HRC-X182_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE182_UKBB-SAIGE-HRC-X182_PRS-CS_MGI_20200608 182 Malignant neoplasm of uterus Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative PRS-CS UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1119236 0.24 0.00138704 0.0832 0.514 0.48-0.547 OR 1.32 0.484-3.59 1.32 0.484-3.59 1.59 0.816-3.08 1.59 0.816-3.08 1.06 0.64-1.76 1.06 0.64-1.76 0.952 0.648-1.4 0.952 0.648-1.4 1.13 0.872-1.45 1.13 0.872-1.45 1.06 0.764-1.46 0.742 1.02 0.736-1.41 0.906 1.16 0.841-1.59 0.373 FALSE FALSE FALSE FALSE Female 327 3240 GRCh37/hg19 auto 2020-06-08 prsweb-phecode182-c54-lassosum-mgi-20200608 prsweb-phecode182-c54-lassosum-mgi-20200608 PRSWEB_PHECODE182_C54_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE182_C54_LASSOSUM_MGI_20200608 182 Diagnoses - main ICD10: C54 Malignant neoplasm of corpus uteri Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative lassosum UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 2360050 0.5 0.0033204 0.0832 0.511 0.478-0.543 OR 0.73 0.198-2.69 0.73 0.198-2.69 0.678 0.258-1.78 0.678 0.258-1.78 1.01 0.599-1.69 1.01 0.599-1.69 1.02 0.702-1.49 1.02 0.702-1.49 1.01 0.778-1.31 1.01 0.778-1.31 1.3 0.942-1.79 0.111 1.1 0.79-1.53 0.575 1.16 0.831-1.61 0.389 FALSE FALSE FALSE FALSE Female 327 3240 GRCh37/hg19 s=0.9;Lambda=0.006952 2020-06-08 prsweb-phecode182-ukbb-saige-hrc-x182-lassosum-mgi-20200608 prsweb-phecode182-ukbb-saige-hrc-x182-lassosum-mgi-20200608 PRSWEB_PHECODE182_UKBB-SAIGE-HRC-X182_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE182_UKBB-SAIGE-HRC-X182_LASSOSUM_MGI_20200608 182 Malignant neoplasm of uterus Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative lassosum UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 333485 0.54 0.00492731 0.0832 0.513 0.48-0.543 OR 0.729 0.198-2.69 0.729 0.198-2.69 0.979 0.432-2.22 0.979 0.432-2.22 0.691 0.376-1.27 0.691 0.376-1.27 0.924 0.626-1.36 0.924 0.626-1.36 0.915 0.7-1.2 0.915 0.7-1.2 1.41 1.02-1.97 0.0397 1.45 1.04-2.01 0.0268 1.16 0.823-1.63 0.398 FALSE FALSE FALSE FALSE Female 327 3240 GRCh37/hg19 s=0.2;Lambda=0.01438 2020-06-08 prsweb-phecode182-gwas-catalog-r2019-05-03-x182-p-5e-05-ukb-20200608 prsweb-phecode182-gwas-catalog-r2019-05-03-x182-p-5e-05-ukb-20200608 PRSWEB_PHECODE182_GWAS-Catalog-r2019-05-03-X182_P_5e-05_UKB_20200608 P_5e-05 PRSWEB_PHECODE182_GWAS-Catalog-r2019-05-03-X182_P_5e-05_UKB_20200608 182 Endometrial cancer;Endometrial cancer (endometrioid histology);Endometrial endometrioid carcinoma;Endometrial cancer (Non-endometrioid histology) Binary 37 unique SNPs UKB UK Biobank Fixed threshold (5e-05) GWAS Catalog (2019-05-03) 21499250;27135401;30093612 https://www.ncbi.nlm.nih.gov/pubmed/?term=21499250+27135401+30093612 34 1.2e-07 0.00389231 0.0822 0.559 0.535-0.581 OR 1.64 0.846-3.17 1.64 0.846-3.17 1.37 0.827-2.28 1.37 0.827-2.28 1.29 0.921-1.81 1.29 0.921-1.81 1.25 0.972-1.61 1.25 0.972-1.61 1.36 1.14-1.63 1.36 1.14-1.63 1.43 1.1-1.86 0.00697 1.83 1.43-2.35 2.11e-06 1.94 1.51-2.49 1.58e-07 TRUE FALSE FALSE FALSE Female 634 6353 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode182-gwas-catalog-r2019-05-03-x182-p-5e-06-ukb-20200608 prsweb-phecode182-gwas-catalog-r2019-05-03-x182-p-5e-06-ukb-20200608 PRSWEB_PHECODE182_GWAS-Catalog-r2019-05-03-X182_P_5e-06_UKB_20200608 P_5e-06 PRSWEB_PHECODE182_GWAS-Catalog-r2019-05-03-X182_P_5e-06_UKB_20200608 182 Endometrial cancer;Endometrial cancer (endometrioid histology);Endometrial endometrioid carcinoma;Endometrial cancer (Non-endometrioid histology) Binary 37 unique SNPs UKB UK Biobank Fixed threshold (5e-06) GWAS Catalog (2019-05-03) 21499250;27135401;30093612 https://www.ncbi.nlm.nih.gov/pubmed/?term=21499250+27135401+30093612 34 1.2e-07 0.00389231 0.0822 0.559 0.535-0.581 OR 1.64 0.846-3.17 1.64 0.846-3.17 1.37 0.827-2.28 1.37 0.827-2.28 1.29 0.921-1.81 1.29 0.921-1.81 1.25 0.972-1.61 1.25 0.972-1.61 1.36 1.14-1.63 1.36 1.14-1.63 1.43 1.1-1.86 0.00697 1.83 1.43-2.35 2.11e-06 1.94 1.51-2.49 1.58e-07 TRUE FALSE FALSE FALSE Female 634 6353 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode182-gwas-catalog-r2019-05-03-x182-p-5e-07-ukb-20200608 prsweb-phecode182-gwas-catalog-r2019-05-03-x182-p-5e-07-ukb-20200608 PRSWEB_PHECODE182_GWAS-Catalog-r2019-05-03-X182_P_5e-07_UKB_20200608 P_5e-07 PRSWEB_PHECODE182_GWAS-Catalog-r2019-05-03-X182_P_5e-07_UKB_20200608 182 Endometrial cancer;Endometrial cancer (endometrioid histology);Endometrial endometrioid carcinoma;Endometrial cancer (Non-endometrioid histology) Binary 37 unique SNPs UKB UK Biobank Fixed threshold (5e-07) GWAS Catalog (2019-05-03) 21499250;27135401;30093612 https://www.ncbi.nlm.nih.gov/pubmed/?term=21499250+27135401+30093612 28 2e-08 0.00635508 0.0822 0.562 0.539-0.585 OR 1.32 0.641-2.73 1.32 0.641-2.73 1.21 0.71-2.07 1.21 0.71-2.07 1.39 1-1.94 1.39 1-1.94 1.3 1.02-1.67 1.3 1.02-1.67 1.41 1.19-1.69 1.41 1.19-1.69 1.49 1.15-1.93 0.0023 1.68 1.31-2.17 5.08e-05 1.97 1.54-2.52 6.95e-08 TRUE FALSE FALSE FALSE Female 634 6353 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode182-gwas-catalog-r2019-05-03-x182-p-5e-09-ukb-20200608 prsweb-phecode182-gwas-catalog-r2019-05-03-x182-p-5e-09-ukb-20200608 PRSWEB_PHECODE182_GWAS-Catalog-r2019-05-03-X182_P_5e-09_UKB_20200608 P_5e-09 PRSWEB_PHECODE182_GWAS-Catalog-r2019-05-03-X182_P_5e-09_UKB_20200608 182 Endometrial cancer;Endometrial cancer (endometrioid histology);Endometrial endometrioid carcinoma;Endometrial cancer (Non-endometrioid histology) Binary 37 unique SNPs UKB UK Biobank Fixed threshold (5e-09) GWAS Catalog (2019-05-03) 21499250;27135401;30093612 https://www.ncbi.nlm.nih.gov/pubmed/?term=21499250+27135401+30093612 11 1.5e-10 0.00801603 0.082 0.577 0.552-0.601 OR 1.32 0.64-2.72 1.32 0.64-2.72 1.29 0.767-2.17 1.29 0.767-2.17 1.74 1.29-2.36 1.74 1.29-2.36 1.63 1.3-2.06 1.63 1.3-2.06 1.56 1.31-1.86 1.56 1.31-1.86 1.54 1.19-2 0.00116 1.69 1.3-2.18 7.02e-05 2.22 1.73-2.84 2.81e-10 TRUE FALSE FALSE FALSE Female 634 6353 GRCh37/hg19 P<=5e-09 2020-06-08 prsweb-phecode182-gwas-catalog-r2019-05-03-x182-p-5e-08-ukb-20200608 prsweb-phecode182-gwas-catalog-r2019-05-03-x182-p-5e-08-ukb-20200608 PRSWEB_PHECODE182_GWAS-Catalog-r2019-05-03-X182_P_5e-08_UKB_20200608 P_5e-08 PRSWEB_PHECODE182_GWAS-Catalog-r2019-05-03-X182_P_5e-08_UKB_20200608 182 Endometrial cancer;Endometrial cancer (endometrioid histology);Endometrial endometrioid carcinoma;Endometrial cancer (Non-endometrioid histology) Binary 37 unique SNPs UKB UK Biobank GWAS Hits GWAS Catalog (2019-05-03) 21499250;27135401;30093612 https://www.ncbi.nlm.nih.gov/pubmed/?term=21499250+27135401+30093612 18 6.9e-11 0.00819174 0.082 0.576 0.553-0.6 OR 2.12 1.17-3.84 2.12 1.17-3.84 1.53 0.945-2.49 1.53 0.945-2.49 1.53 1.12-2.11 1.53 1.12-2.11 1.53 1.21-1.94 1.53 1.21-1.94 1.65 1.39-1.96 1.65 1.39-1.96 1.36 1.04-1.77 0.0224 1.64 1.27-2.11 0.000148 2.21 1.73-2.81 1.82e-10 TRUE FALSE FALSE TRUE Female 634 6353 GRCh37/hg19 P<=5e-08 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000541/ScoringFiles/ phewas/PRSWEB_PHECODE182_GWAS-Catalog-r2019-05-03-X182_P_5e-08_UKB_20200608/all.tsv phewas/PRSWEB_PHECODE182_GWAS-Catalog-r2019-05-03-X182_P_5e-08_UKB_20200608/exclusion.tsv 2020-06-08 prsweb-phecode182-gwas-catalog-r2019-05-03-x182-pt-ukb-20200608 prsweb-phecode182-gwas-catalog-r2019-05-03-x182-pt-ukb-20200608 PRSWEB_PHECODE182_GWAS-Catalog-r2019-05-03-X182_PT_UKB_20200608 P&T PRSWEB_PHECODE182_GWAS-Catalog-r2019-05-03-X182_PT_UKB_20200608 182 Endometrial cancer;Endometrial cancer (endometrioid histology);Endometrial endometrioid carcinoma;Endometrial cancer (Non-endometrioid histology) Binary 37 unique SNPs UKB UK Biobank P&T GWAS Catalog (2019-05-03) 21499250;27135401;30093612 https://www.ncbi.nlm.nih.gov/pubmed/?term=21499250+27135401+30093612 20 2.3e-10 0.00840184 0.082 0.572 0.549-0.596 OR 2.6 1.5-4.51 2.6 1.5-4.51 1.62 1.01-2.6 1.62 1.01-2.6 1.6 1.17-2.19 1.6 1.17-2.19 1.38 1.08-1.76 1.38 1.08-1.76 1.54 1.29-1.83 1.54 1.29-1.83 1.39 1.07-1.8 0.0131 1.6 1.24-2.06 0.000262 2.04 1.6-2.6 7.84e-09 TRUE FALSE FALSE TRUE Female 634 6353 GRCh37/hg19 P<=1e-07 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000542/ScoringFiles/ phewas/PRSWEB_PHECODE182_GWAS-Catalog-r2019-05-03-X182_PT_UKB_20200608/all.tsv phewas/PRSWEB_PHECODE182_GWAS-Catalog-r2019-05-03-X182_PT_UKB_20200608/exclusion.tsv 2020-06-08 prsweb-phecode184-c3-female-genital-p-5e-05-mgi-20200608 prsweb-phecode184-c3-female-genital-p-5e-05-mgi-20200608 PRSWEB_PHECODE184_C3-FEMALE-GENITAL_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE184_C3-FEMALE-GENITAL_P_5e-05_MGI_20200608 184 malignant neoplasm of female genital organs Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 105 0.64 0.000360099 0.0837 0.507 0.479-0.537 OR 0.76 0.253-2.29 0.76 0.253-2.29 1.15 0.602-2.2 1.15 0.602-2.2 0.85 0.53-1.37 0.85 0.53-1.37 0.979 0.708-1.35 0.979 0.708-1.35 1.03 0.822-1.28 1.03 0.822-1.28 1.02 0.771-1.35 0.89 1.2 0.914-1.57 0.191 1.1 0.836-1.45 0.489 FALSE FALSE FALSE FALSE Female 453 4452 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode184-c3-female-genital-p-5e-06-mgi-20200608 prsweb-phecode184-c3-female-genital-p-5e-06-mgi-20200608 PRSWEB_PHECODE184_C3-FEMALE-GENITAL_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE184_C3-FEMALE-GENITAL_P_5e-06_MGI_20200608 184 malignant neoplasm of female genital organs Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 11 0.0049 0.000118494 0.0836 0.517 0.488-0.544 OR 2.09 1.03-4.27 2.09 1.03-4.27 1.38 0.755-2.52 1.38 0.755-2.52 1.56 1.07-2.26 1.56 1.07-2.26 1.43 1.08-1.9 1.43 1.08-1.9 1.24 1-1.53 1.24 1-1.53 1.18 0.885-1.57 0.26 1.29 0.969-1.71 0.082 1.42 1.08-1.87 0.0133 TRUE FALSE FALSE FALSE Female 453 4452 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode184-c3-female-genital-pt-mgi-20200608 prsweb-phecode184-c3-female-genital-pt-mgi-20200608 PRSWEB_PHECODE184_C3-FEMALE-GENITAL_PT_MGI_20200608 P&T PRSWEB_PHECODE184_C3-FEMALE-GENITAL_PT_MGI_20200608 184 malignant neoplasm of female genital organs Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative P&T UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 8 0.0043 0.00127792 0.0836 0.51 0.483-0.537 OR 1.63 0.743-3.57 1.63 0.743-3.57 1.7 0.979-2.94 1.7 0.979-2.94 1.56 1.08-2.27 1.56 1.08-2.27 1.49 1.12-1.97 1.49 1.12-1.97 1.22 0.988-1.51 1.22 0.988-1.51 1.06 0.792-1.42 0.688 1.39 1.05-1.84 0.0195 1.41 1.07-1.86 0.0144 TRUE FALSE FALSE TRUE Female 453 4452 GRCh37/hg19 P<=2e-06 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000543/ScoringFiles/ phewas/PRSWEB_PHECODE184_C3-FEMALE-GENITAL_PT_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE184_C3-FEMALE-GENITAL_PT_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode184-c3-female-genital-prs-cs-mgi-20200608 prsweb-phecode184-c3-female-genital-prs-cs-mgi-20200608 PRSWEB_PHECODE184_C3-FEMALE-GENITAL_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE184_C3-FEMALE-GENITAL_PRS-CS_MGI_20200608 184 malignant neoplasm of female genital organs Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative PRS-CS UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1111495 0.81 3.06796e-05 0.0837 0.507 0.479-0.533 OR 0.545 0.15-1.97 0.545 0.15-1.97 0.703 0.315-1.57 0.703 0.315-1.57 0.934 0.594-1.47 0.934 0.594-1.47 0.988 0.717-1.36 0.988 0.717-1.36 1.17 0.944-1.45 1.17 0.944-1.45 0.905 0.687-1.19 0.479 0.911 0.692-1.2 0.508 1.09 0.836-1.42 0.526 FALSE FALSE FALSE FALSE Female 453 4452 GRCh37/hg19 auto 2020-06-08 prsweb-phecode184-c3-female-genital-lassosum-mgi-20200608 prsweb-phecode184-c3-female-genital-lassosum-mgi-20200608 PRSWEB_PHECODE184_C3-FEMALE-GENITAL_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE184_C3-FEMALE-GENITAL_LASSOSUM_MGI_20200608 184 malignant neoplasm of female genital organs Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. Quartile analysis was unavailable in the source output. MGI Michigan Genomics Initiative lassosum UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 6 0.1 0.0016906 0.0837 0.464 0.44-0.491 OR 1.65 0.753-3.62 1.65 0.753-3.62 1.35 0.758-2.41 1.35 0.758-2.41 1.33 0.892-1.97 1.33 0.892-1.97 1.1 0.817-1.48 1.1 0.817-1.48 1.19 0.958-1.47 1.19 0.958-1.47 FALSE FALSE FALSE FALSE Female 453 4452 GRCh37/hg19 s=0.2;Lambda=0.04833 2020-06-08 prsweb-phecode184-11-20001-1039-p-5e-05-mgi-20200608 prsweb-phecode184-11-20001-1039-p-5e-05-mgi-20200608 PRSWEB_PHECODE184.11_20001-1039_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE184.11_20001-1039_P_5e-05_MGI_20200608 184.11 Cancer code, self-reported: ovarian cancer Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 100 0.36 0.00192304 0.0829 0.514 0.466-0.558 OR 2.36 0.813-6.87 2.36 0.813-6.87 2.11 0.936-4.75 2.11 0.936-4.75 1.54 0.847-2.79 1.54 0.847-2.79 1.26 0.779-2.02 1.26 0.779-2.02 1.12 0.787-1.58 1.12 0.787-1.58 0.907 0.576-1.43 0.675 1.08 0.703-1.67 0.714 1.11 0.719-1.7 0.647 FALSE FALSE FALSE FALSE Female 174 1730 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode184-11-c56-p-5e-05-mgi-20200608 prsweb-phecode184-11-c56-p-5e-05-mgi-20200608 PRSWEB_PHECODE184.11_C56_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE184.11_C56_P_5e-05_MGI_20200608 184.11 Diagnoses - main ICD10: C56 Malignant neoplasm of ovary Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 101 0.49 4.73552e-05 0.0829 0.505 0.459-0.551 OR 1.35 0.347-5.26 1.35 0.347-5.26 1.28 0.47-3.5 1.28 0.47-3.5 1.71 0.959-3.06 1.71 0.959-3.06 1.2 0.741-1.96 1.2 0.741-1.96 1.02 0.716-1.46 1.02 0.716-1.46 0.987 0.636-1.53 0.953 1.02 0.66-1.58 0.928 1 0.649-1.55 0.984 FALSE FALSE FALSE FALSE Female 174 1730 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode184-11-gwas-catalog-r2019-05-03-x184-11-p-5e-05-mgi-20200608 prsweb-phecode184-11-gwas-catalog-r2019-05-03-x184-11-p-5e-05-mgi-20200608 PRSWEB_PHECODE184.11_GWAS-Catalog-r2019-05-03-X184.11_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE184.11_GWAS-Catalog-r2019-05-03-X184.11_P_5e-05_MGI_20200608 184.11 Epithelial ovarian cancer;High-grade serous ovarian cancer;Serous invasive ovarian cancer;Invasive epithelial ovarian cancer;Mucinous ovarian carcinoma;Low-grade serous and serous borderline ovarian cancer;Serous borderline ovarian cancer;Ovarian cancer in BRCA1 mutation carriers;Ovarian cancer;Ovarian clear cell cancer Binary 32 unique SNPs MGI Michigan Genomics Initiative Fixed threshold (5e-05) GWAS Catalog (2019-05-03) 19648919;21964575;23544013;25581431;28346442 https://www.ncbi.nlm.nih.gov/pubmed/?term=19648919+21964575+23544013+25581431+28346442 25 0.15 0.00181869 0.0828 0.532 0.484-0.58 OR 1.37 0.351-5.35 1.37 0.351-5.35 1.29 0.473-3.52 1.29 0.473-3.52 1.2 0.619-2.33 1.2 0.619-2.33 0.879 0.51-1.51 0.879 0.51-1.51 1.19 0.843-1.68 1.19 0.843-1.68 1.16 0.727-1.85 0.535 1.36 0.864-2.13 0.185 1.4 0.898-2.19 0.137 FALSE FALSE FALSE FALSE Female 174 1730 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode184-11-phelan-hsoc-p-5e-05-mgi-20200608 prsweb-phecode184-11-phelan-hsoc-p-5e-05-mgi-20200608 PRSWEB_PHECODE184.11_Phelan-HSOC_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE184.11_Phelan-HSOC_P_5e-05_MGI_20200608 184.11 High-grade serous ovarian cancer Binary High-grade serous ovarian cancer MGI Michigan Genomics Initiative Fixed threshold (5e-05) Phelan CM et al. 2017 28346442 https://www.ncbi.nlm.nih.gov/pubmed/?term=28346442 116 0.31 0.000774043 0.0829 0.513 0.473-0.557 OR 1.86 0.571-6.04 1.86 0.571-6.04 1.55 0.616-3.89 1.55 0.616-3.89 1.2 0.621-2.33 1.2 0.621-2.33 1.12 0.683-1.84 1.12 0.683-1.84 0.958 0.668-1.37 0.958 0.668-1.37 1.04 0.671-1.62 0.858 1.11 0.718-1.71 0.642 1.01 0.648-1.57 0.969 FALSE FALSE FALSE FALSE Female 174 1730 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode184-11-phelan-ieoc-p-5e-05-mgi-20200608 prsweb-phecode184-11-phelan-ieoc-p-5e-05-mgi-20200608 PRSWEB_PHECODE184.11_Phelan-IEOC_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE184.11_Phelan-IEOC_P_5e-05_MGI_20200608 184.11 Invasive epithelial ovarian cancer Binary Invasive epithelial ovarian cancer MGI Michigan Genomics Initiative Fixed threshold (5e-05) Phelan CM et al. 2017 28346442 https://www.ncbi.nlm.nih.gov/pubmed/?term=28346442 219 0.4 1.94556e-05 0.0829 0.527 0.488-0.57 OR 0.814 0.148-4.49 0.814 0.148-4.49 0.71 0.193-2.61 0.71 0.193-2.61 0.844 0.393-1.81 0.844 0.393-1.81 0.945 0.556-1.61 0.945 0.556-1.61 0.991 0.693-1.42 0.991 0.693-1.42 1.2 0.754-1.9 0.447 1.52 0.979-2.37 0.0623 1.22 0.771-1.94 0.392 FALSE FALSE FALSE FALSE Female 174 1730 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode184-11-phelan-mcoc-p-5e-05-mgi-20200608 prsweb-phecode184-11-phelan-mcoc-p-5e-05-mgi-20200608 PRSWEB_PHECODE184.11_Phelan-MCOC_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE184.11_Phelan-MCOC_P_5e-05_MGI_20200608 184.11 Mucinous ovarian carcinoma Binary Mucinous ovarian carcinoma MGI Michigan Genomics Initiative Fixed threshold (5e-05) Phelan CM et al. 2017 28346442 https://www.ncbi.nlm.nih.gov/pubmed/?term=28346442 131 0.13 0.000695458 0.0828 0.529 0.487-0.571 OR 1.81 0.556-5.91 1.81 0.556-5.91 1.25 0.458-3.42 1.25 0.458-3.42 1.3 0.686-2.46 1.3 0.686-2.46 1.37 0.864-2.18 1.37 0.864-2.18 1.2 0.852-1.7 1.2 0.852-1.7 1.57 1-2.46 0.0497 1.16 0.722-1.87 0.534 1.49 0.947-2.34 0.0848 FALSE FALSE FALSE FALSE Female 174 1730 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode184-11-phelan-sioc-p-5e-05-mgi-20200608 prsweb-phecode184-11-phelan-sioc-p-5e-05-mgi-20200608 PRSWEB_PHECODE184.11_Phelan-SIOC_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE184.11_Phelan-SIOC_P_5e-05_MGI_20200608 184.11 Serous invasive ovarian cancer Binary Serous invasive ovarian cancer MGI Michigan Genomics Initiative Fixed threshold (5e-05) Phelan CM et al. 2017 28346442 https://www.ncbi.nlm.nih.gov/pubmed/?term=28346442 207 0.095 0.00273239 0.0828 0.552 0.506-0.59 OR 0.797 0.145-4.4 0.797 0.145-4.4 0.699 0.19-2.57 0.699 0.19-2.57 0.853 0.398-1.83 0.853 0.398-1.83 0.755 0.425-1.34 0.755 0.425-1.34 1.39 0.994-1.94 1.39 0.994-1.94 0.989 0.605-1.62 0.966 1.62 1.03-2.54 0.0358 1.66 1.07-2.6 0.025 FALSE FALSE FALSE FALSE Female 174 1730 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode184-11-20001-1039-p-5e-06-mgi-20200608 prsweb-phecode184-11-20001-1039-p-5e-06-mgi-20200608 PRSWEB_PHECODE184.11_20001-1039_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE184.11_20001-1039_P_5e-06_MGI_20200608 184.11 Cancer code, self-reported: ovarian cancer Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 18 0.28 0.00168378 0.0829 0.503 0.46-0.549 OR 2.36 0.812-6.85 2.36 0.812-6.85 2.09 0.927-4.7 2.09 0.927-4.7 1.54 0.848-2.8 1.54 0.848-2.8 1.17 0.722-1.91 1.17 0.722-1.91 0.953 0.664-1.37 0.953 0.664-1.37 1.38 0.873-2.18 0.168 1.41 0.904-2.21 0.129 1.17 0.735-1.87 0.504 FALSE FALSE FALSE FALSE Female 174 1730 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode184-11-c56-p-5e-06-mgi-20200608 prsweb-phecode184-11-c56-p-5e-06-mgi-20200608 PRSWEB_PHECODE184.11_C56_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE184.11_C56_P_5e-06_MGI_20200608 184.11 Diagnoses - main ICD10: C56 Malignant neoplasm of ovary Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 10 0.52 0.0007011 0.0829 0.496 0.449-0.541 OR 1.41 0.36-5.49 1.41 0.36-5.49 0.714 0.194-2.63 0.714 0.194-2.63 1.59 0.872-2.88 1.59 0.872-2.88 1.53 0.975-2.39 1.53 0.975-2.39 1.11 0.782-1.57 1.11 0.782-1.57 0.512 0.316-0.829 0.00643 0.945 0.629-1.42 0.787 0.896 0.593-1.35 0.603 FALSE FALSE FALSE FALSE Female 174 1730 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode184-11-gwas-catalog-r2019-05-03-x184-11-p-5e-06-mgi-20200608 prsweb-phecode184-11-gwas-catalog-r2019-05-03-x184-11-p-5e-06-mgi-20200608 PRSWEB_PHECODE184.11_GWAS-Catalog-r2019-05-03-X184.11_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE184.11_GWAS-Catalog-r2019-05-03-X184.11_P_5e-06_MGI_20200608 184.11 Epithelial ovarian cancer;High-grade serous ovarian cancer;Serous invasive ovarian cancer;Invasive epithelial ovarian cancer;Mucinous ovarian carcinoma;Low-grade serous and serous borderline ovarian cancer;Serous borderline ovarian cancer;Ovarian cancer in BRCA1 mutation carriers;Ovarian cancer;Ovarian clear cell cancer Binary 32 unique SNPs MGI Michigan Genomics Initiative Fixed threshold (5e-06) GWAS Catalog (2019-05-03) 19648919;21964575;23544013;25581431;28346442 https://www.ncbi.nlm.nih.gov/pubmed/?term=19648919+21964575+23544013+25581431+28346442 25 0.15 0.00181869 0.0828 0.532 0.484-0.58 OR 1.37 0.351-5.35 1.37 0.351-5.35 1.29 0.473-3.52 1.29 0.473-3.52 1.2 0.619-2.33 1.2 0.619-2.33 0.879 0.51-1.51 0.879 0.51-1.51 1.19 0.843-1.68 1.19 0.843-1.68 1.16 0.727-1.85 0.535 1.36 0.864-2.13 0.185 1.4 0.898-2.19 0.137 FALSE FALSE FALSE FALSE Female 174 1730 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode184-11-phelan-epoc-p-5e-06-mgi-20200608 prsweb-phecode184-11-phelan-epoc-p-5e-06-mgi-20200608 PRSWEB_PHECODE184.11_Phelan-EPOC_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE184.11_Phelan-EPOC_P_5e-06_MGI_20200608 184.11 Epithelial ovarian cancer Binary Epithelial ovarian cancer MGI Michigan Genomics Initiative Fixed threshold (5e-06) Phelan CM et al. 2017 28346442 https://www.ncbi.nlm.nih.gov/pubmed/?term=28346442 26 0.44 0.000436443 0.0829 0.525 0.481-0.57 OR 1.34 0.343-5.22 1.34 0.343-5.22 0.967 0.316-2.96 0.967 0.316-2.96 0.831 0.388-1.78 0.831 0.388-1.78 1.18 0.726-1.92 1.18 0.726-1.92 1.24 0.882-1.75 1.24 0.882-1.75 0.879 0.555-1.39 0.584 1.1 0.712-1.71 0.662 1.26 0.819-1.93 0.295 FALSE FALSE FALSE FALSE Female 174 1730 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode184-11-phelan-hsoc-p-5e-06-mgi-20200608 prsweb-phecode184-11-phelan-hsoc-p-5e-06-mgi-20200608 PRSWEB_PHECODE184.11_Phelan-HSOC_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE184.11_Phelan-HSOC_P_5e-06_MGI_20200608 184.11 High-grade serous ovarian cancer Binary High-grade serous ovarian cancer MGI Michigan Genomics Initiative Fixed threshold (5e-06) Phelan CM et al. 2017 28346442 https://www.ncbi.nlm.nih.gov/pubmed/?term=28346442 14 0.36 0.000809453 0.0829 0.514 0.472-0.558 OR 0 0-0 0 0-0 0.688 0.187-2.53 0.688 0.187-2.53 1.2 0.621-2.33 1.2 0.621-2.33 1.26 0.781-2.03 1.26 0.781-2.03 1.18 0.835-1.67 1.18 0.835-1.67 1.1 0.71-1.71 0.663 0.938 0.597-1.47 0.781 1.19 0.771-1.83 0.436 FALSE FALSE FALSE FALSE Female 174 1730 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode184-11-phelan-ieoc-p-5e-06-mgi-20200608 prsweb-phecode184-11-phelan-ieoc-p-5e-06-mgi-20200608 PRSWEB_PHECODE184.11_Phelan-IEOC_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE184.11_Phelan-IEOC_P_5e-06_MGI_20200608 184.11 Invasive epithelial ovarian cancer Binary Invasive epithelial ovarian cancer MGI Michigan Genomics Initiative Fixed threshold (5e-06) Phelan CM et al. 2017 28346442 https://www.ncbi.nlm.nih.gov/pubmed/?term=28346442 54 0.03 0.000383676 0.0827 0.554 0.509-0.595 OR 0.806 0.146-4.44 0.806 0.146-4.44 0.99 0.323-3.03 0.99 0.323-3.03 0.847 0.395-1.82 0.847 0.395-1.82 1.24 0.772-2 1.24 0.772-2 1.11 0.782-1.57 1.11 0.782-1.57 2.17 1.34-3.52 0.00172 1.9 1.16-3.11 0.0107 1.81 1.11-2.97 0.0183 TRUE FALSE FALSE FALSE Female 174 1730 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode184-11-phelan-lsasboc-p-5e-06-mgi-20200608 prsweb-phecode184-11-phelan-lsasboc-p-5e-06-mgi-20200608 PRSWEB_PHECODE184.11_Phelan-LSASBOC_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE184.11_Phelan-LSASBOC_P_5e-06_MGI_20200608 184.11 Low-grade serous and serous borderline ovarian cancer Binary Low-grade serous and serous borderline ovarian cancer MGI Michigan Genomics Initiative Fixed threshold (5e-06) Phelan CM et al. 2017 28346442 https://www.ncbi.nlm.nih.gov/pubmed/?term=28346442 28 0.84 0.00757031 0.0829 0.51 0.466-0.555 OR 0 0-0 0 0-0 0.135 0.00815-2.25 0.135 0.00815-2.25 0.486 0.186-1.27 0.486 0.186-1.27 0.926 0.546-1.57 0.926 0.546-1.57 1.15 0.813-1.63 1.15 0.813-1.63 0.788 0.503-1.24 0.299 0.953 0.62-1.46 0.827 1.03 0.679-1.58 0.874 FALSE FALSE FALSE FALSE Female 174 1730 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode184-11-phelan-mcoc-p-5e-06-mgi-20200608 prsweb-phecode184-11-phelan-mcoc-p-5e-06-mgi-20200608 PRSWEB_PHECODE184.11_Phelan-MCOC_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE184.11_Phelan-MCOC_P_5e-06_MGI_20200608 184.11 Mucinous ovarian carcinoma Binary Mucinous ovarian carcinoma MGI Michigan Genomics Initiative Fixed threshold (5e-06) Phelan CM et al. 2017 28346442 https://www.ncbi.nlm.nih.gov/pubmed/?term=28346442 27 0.23 0.00203756 0.0829 0.525 0.484-0.57 OR 1.36 0.349-5.28 1.36 0.349-5.28 1.83 0.775-4.33 1.83 0.775-4.33 1.08 0.544-2.16 1.08 0.544-2.16 1.2 0.734-1.95 1.2 0.734-1.95 1.18 0.835-1.67 1.18 0.835-1.67 1.21 0.771-1.91 0.402 1.23 0.783-1.94 0.369 1.37 0.877-2.14 0.166 FALSE FALSE FALSE FALSE Female 174 1730 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode184-11-phelan-occc-p-5e-06-mgi-20200608 prsweb-phecode184-11-phelan-occc-p-5e-06-mgi-20200608 PRSWEB_PHECODE184.11_Phelan-OCCC_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE184.11_Phelan-OCCC_P_5e-06_MGI_20200608 184.11 Ovarian clear cell cancer Binary Ovarian clear cell cancer MGI Michigan Genomics Initiative Fixed threshold (5e-06) Phelan CM et al. 2017 28346442 https://www.ncbi.nlm.nih.gov/pubmed/?term=28346442 12 0.31 0.000512137 0.0829 0.528 0.482-0.573 OR 3.59 1.42-9.08 3.59 1.42-9.08 3.36 1.68-6.69 3.36 1.68-6.69 1.73 0.968-3.09 1.73 0.968-3.09 1.21 0.743-1.97 1.21 0.743-1.97 1.07 0.748-1.52 1.07 0.748-1.52 1.02 0.657-1.6 0.916 1.13 0.728-1.74 0.592 1.13 0.73-1.76 0.575 FALSE FALSE FALSE FALSE Female 174 1730 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode184-11-phelan-sioc-p-5e-06-mgi-20200608 prsweb-phecode184-11-phelan-sioc-p-5e-06-mgi-20200608 PRSWEB_PHECODE184.11_Phelan-SIOC_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE184.11_Phelan-SIOC_P_5e-06_MGI_20200608 184.11 Serous invasive ovarian cancer Binary Serous invasive ovarian cancer MGI Michigan Genomics Initiative Fixed threshold (5e-06) Phelan CM et al. 2017 28346442 https://www.ncbi.nlm.nih.gov/pubmed/?term=28346442 58 0.17 0.00147602 0.0829 0.535 0.491-0.577 OR 0 0-0 0 0-0 1.26 0.461-3.42 1.26 0.461-3.42 0.956 0.464-1.97 0.956 0.464-1.97 0.987 0.588-1.66 0.987 0.588-1.66 1.15 0.81-1.62 1.15 0.81-1.62 1.35 0.841-2.17 0.213 1.59 1.01-2.52 0.0457 1.5 0.947-2.38 0.0843 FALSE FALSE FALSE FALSE Female 174 1730 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode184-11-gwas-catalog-r2019-05-03-x184-11-p-5e-07-mgi-20200608 prsweb-phecode184-11-gwas-catalog-r2019-05-03-x184-11-p-5e-07-mgi-20200608 PRSWEB_PHECODE184.11_GWAS-Catalog-r2019-05-03-X184.11_P_5e-07_MGI_20200608 P_5e-07 PRSWEB_PHECODE184.11_GWAS-Catalog-r2019-05-03-X184.11_P_5e-07_MGI_20200608 184.11 Epithelial ovarian cancer;High-grade serous ovarian cancer;Serous invasive ovarian cancer;Invasive epithelial ovarian cancer;Mucinous ovarian carcinoma;Low-grade serous and serous borderline ovarian cancer;Serous borderline ovarian cancer;Ovarian cancer in BRCA1 mutation carriers;Ovarian cancer;Ovarian clear cell cancer Binary 32 unique SNPs MGI Michigan Genomics Initiative Fixed threshold (5e-07) GWAS Catalog (2019-05-03) 19648919;21964575;23544013;25581431;28346442 https://www.ncbi.nlm.nih.gov/pubmed/?term=19648919+21964575+23544013+25581431+28346442 23 0.16 0.00155655 0.0828 0.531 0.481-0.578 OR 1.36 0.35-5.32 1.36 0.35-5.32 1.28 0.471-3.5 1.28 0.471-3.5 1.2 0.62-2.33 1.2 0.62-2.33 1.01 0.599-1.69 1.01 0.599-1.69 1.16 0.817-1.64 1.16 0.817-1.64 0.953 0.594-1.53 0.843 1.37 0.884-2.12 0.159 1.31 0.844-2.05 0.227 FALSE FALSE FALSE FALSE Female 174 1730 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode184-11-phelan-epoc-p-5e-07-mgi-20200608 prsweb-phecode184-11-phelan-epoc-p-5e-07-mgi-20200608 PRSWEB_PHECODE184.11_Phelan-EPOC_P_5e-07_MGI_20200608 P_5e-07 PRSWEB_PHECODE184.11_Phelan-EPOC_P_5e-07_MGI_20200608 184.11 Epithelial ovarian cancer Binary Epithelial ovarian cancer MGI Michigan Genomics Initiative Fixed threshold (5e-07) Phelan CM et al. 2017 28346442 https://www.ncbi.nlm.nih.gov/pubmed/?term=28346442 7 0.94 0.000912008 0.0829 0.5 0.456-0.548 OR 1.33 0.343-5.18 1.33 0.343-5.18 1.26 0.462-3.43 1.26 0.462-3.43 1.42 0.766-2.63 1.42 0.766-2.63 1.45 0.919-2.28 1.45 0.919-2.28 1.05 0.735-1.49 1.05 0.735-1.49 1.07 0.699-1.64 0.75 0.905 0.578-1.42 0.663 1.01 0.656-1.55 0.963 FALSE FALSE FALSE FALSE Female 174 1730 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode184-11-phelan-ieoc-p-5e-07-mgi-20200608 prsweb-phecode184-11-phelan-ieoc-p-5e-07-mgi-20200608 PRSWEB_PHECODE184.11_Phelan-IEOC_P_5e-07_MGI_20200608 P_5e-07 PRSWEB_PHECODE184.11_Phelan-IEOC_P_5e-07_MGI_20200608 184.11 Invasive epithelial ovarian cancer Binary Invasive epithelial ovarian cancer MGI Michigan Genomics Initiative Fixed threshold (5e-07) Phelan CM et al. 2017 28346442 https://www.ncbi.nlm.nih.gov/pubmed/?term=28346442 23 0.064 0.000652689 0.0828 0.545 0.504-0.589 OR 0 0-0 0 0-0 0.991 0.323-3.04 0.991 0.323-3.04 0.849 0.396-1.82 0.849 0.396-1.82 1.2 0.738-1.95 1.2 0.738-1.95 1.43 1.02-2 1.43 1.02-2 1.27 0.795-2.03 0.317 1.26 0.79-2.01 0.331 1.68 1.07-2.61 0.0227 FALSE FALSE FALSE FALSE Female 174 1730 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode184-11-phelan-lsasboc-p-5e-07-mgi-20200608 prsweb-phecode184-11-phelan-lsasboc-p-5e-07-mgi-20200608 PRSWEB_PHECODE184.11_Phelan-LSASBOC_P_5e-07_MGI_20200608 P_5e-07 PRSWEB_PHECODE184.11_Phelan-LSASBOC_P_5e-07_MGI_20200608 184.11 Low-grade serous and serous borderline ovarian cancer Binary Low-grade serous and serous borderline ovarian cancer MGI Michigan Genomics Initiative Fixed threshold (5e-07) Phelan CM et al. 2017 28346442 https://www.ncbi.nlm.nih.gov/pubmed/?term=28346442 13 0.82 0.00474436 0.0829 0.511 0.462-0.556 OR 0.804 0.146-4.43 0.804 0.146-4.43 0.692 0.188-2.54 0.692 0.188-2.54 0.964 0.468-1.98 0.964 0.468-1.98 0.872 0.507-1.5 0.872 0.507-1.5 1.31 0.933-1.84 1.31 0.933-1.84 0.956 0.619-1.48 0.839 0.765 0.481-1.22 0.257 1.15 0.762-1.75 0.499 FALSE FALSE FALSE FALSE Female 174 1730 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode184-11-phelan-mcoc-p-5e-07-mgi-20200608 prsweb-phecode184-11-phelan-mcoc-p-5e-07-mgi-20200608 PRSWEB_PHECODE184.11_Phelan-MCOC_P_5e-07_MGI_20200608 P_5e-07 PRSWEB_PHECODE184.11_Phelan-MCOC_P_5e-07_MGI_20200608 184.11 Mucinous ovarian carcinoma Binary Mucinous ovarian carcinoma MGI Michigan Genomics Initiative Fixed threshold (5e-07) Phelan CM et al. 2017 28346442 https://www.ncbi.nlm.nih.gov/pubmed/?term=28346442 8 0.17 0.00117828 0.0829 0.532 0.487-0.578 OR 2.43 0.84-7.05 2.43 0.84-7.05 2.14 0.95-4.81 2.14 0.95-4.81 1.45 0.782-2.68 1.45 0.782-2.68 0.936 0.551-1.59 0.936 0.551-1.59 1.18 0.835-1.67 1.18 0.835-1.67 1.12 0.711-1.78 0.617 1.27 0.81-1.99 0.298 1.31 0.842-2.04 0.23 FALSE FALSE FALSE FALSE Female 174 1730 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode184-11-phelan-sioc-p-5e-07-mgi-20200608 prsweb-phecode184-11-phelan-sioc-p-5e-07-mgi-20200608 PRSWEB_PHECODE184.11_Phelan-SIOC_P_5e-07_MGI_20200608 P_5e-07 PRSWEB_PHECODE184.11_Phelan-SIOC_P_5e-07_MGI_20200608 184.11 Serous invasive ovarian cancer Binary Serous invasive ovarian cancer MGI Michigan Genomics Initiative Fixed threshold (5e-07) Phelan CM et al. 2017 28346442 https://www.ncbi.nlm.nih.gov/pubmed/?term=28346442 31 0.033 0.000451538 0.0827 0.548 0.506-0.592 OR 0.801 0.145-4.43 0.801 0.145-4.43 0.976 0.319-2.99 0.976 0.319-2.99 0.951 0.461-1.96 0.951 0.461-1.96 1.38 0.872-2.2 1.38 0.872-2.2 1.38 0.99-1.94 1.38 0.99-1.94 1.61 1-2.58 0.0501 1.42 0.873-2.3 0.159 1.88 1.18-2.98 0.00742 TRUE FALSE FALSE FALSE Female 174 1730 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode184-11-gwas-catalog-r2019-05-03-x184-11-p-5e-09-mgi-20200608 prsweb-phecode184-11-gwas-catalog-r2019-05-03-x184-11-p-5e-09-mgi-20200608 PRSWEB_PHECODE184.11_GWAS-Catalog-r2019-05-03-X184.11_P_5e-09_MGI_20200608 P_5e-09 PRSWEB_PHECODE184.11_GWAS-Catalog-r2019-05-03-X184.11_P_5e-09_MGI_20200608 184.11 Epithelial ovarian cancer;High-grade serous ovarian cancer;Serous invasive ovarian cancer;Invasive epithelial ovarian cancer;Mucinous ovarian carcinoma;Low-grade serous and serous borderline ovarian cancer;Serous borderline ovarian cancer;Ovarian cancer in BRCA1 mutation carriers;Ovarian cancer;Ovarian clear cell cancer Binary 32 unique SNPs MGI Michigan Genomics Initiative Fixed threshold (5e-09) GWAS Catalog (2019-05-03) 19648919;21964575;23544013;25581431;28346442 https://www.ncbi.nlm.nih.gov/pubmed/?term=19648919+21964575+23544013+25581431+28346442 14 0.27 0.0042369 0.0829 0.526 0.481-0.571 OR 0.803 0.145-4.43 0.803 0.145-4.43 0.688 0.187-2.53 0.688 0.187-2.53 0.84 0.391-1.8 0.84 0.391-1.8 0.994 0.592-1.67 0.994 0.592-1.67 1.15 0.816-1.63 1.15 0.816-1.63 1.76 1.1-2.83 0.0192 1.69 1.05-2.72 0.031 1.7 1.06-2.74 0.0292 FALSE FALSE FALSE FALSE Female 174 1730 GRCh37/hg19 P<=5e-09 2020-06-08 prsweb-phecode184-11-phelan-epoc-p-5e-09-mgi-20200608 prsweb-phecode184-11-phelan-epoc-p-5e-09-mgi-20200608 PRSWEB_PHECODE184.11_Phelan-EPOC_P_5e-09_MGI_20200608 P_5e-09 PRSWEB_PHECODE184.11_Phelan-EPOC_P_5e-09_MGI_20200608 184.11 Epithelial ovarian cancer Binary Epithelial ovarian cancer MGI Michigan Genomics Initiative Fixed threshold (5e-09) Phelan CM et al. 2017 28346442 https://www.ncbi.nlm.nih.gov/pubmed/?term=28346442 5 0.75 0.00770036 0.0829 0.504 0.46-0.551 OR 1.9 0.582-6.23 1.9 0.582-6.23 1.26 0.459-3.46 1.26 0.459-3.46 1.16 0.599-2.25 1.16 0.599-2.25 1.39 0.874-2.2 1.39 0.874-2.2 1.05 0.737-1.5 1.05 0.737-1.5 0.85 0.549-1.32 0.467 0.891 0.578-1.37 0.599 0.939 0.614-1.44 0.773 FALSE FALSE FALSE FALSE Female 174 1730 GRCh37/hg19 P<=5e-09 2020-06-08 prsweb-phecode184-11-phelan-ieoc-p-5e-09-mgi-20200608 prsweb-phecode184-11-phelan-ieoc-p-5e-09-mgi-20200608 PRSWEB_PHECODE184.11_Phelan-IEOC_P_5e-09_MGI_20200608 P_5e-09 PRSWEB_PHECODE184.11_Phelan-IEOC_P_5e-09_MGI_20200608 184.11 Invasive epithelial ovarian cancer Binary Invasive epithelial ovarian cancer MGI Michigan Genomics Initiative Fixed threshold (5e-09) Phelan CM et al. 2017 28346442 https://www.ncbi.nlm.nih.gov/pubmed/?term=28346442 13 0.053 0.000627797 0.0828 0.545 0.5-0.592 OR 1.31 0.337-5.12 1.31 0.337-5.12 0.682 0.185-2.51 0.682 0.185-2.51 1.08 0.539-2.14 1.08 0.539-2.14 1.46 0.928-2.3 1.46 0.928-2.3 1.36 0.971-1.91 1.36 0.971-1.91 1.25 0.785-2 0.343 1.33 0.837-2.12 0.227 1.62 1.04-2.54 0.0338 FALSE FALSE FALSE FALSE Female 174 1730 GRCh37/hg19 P<=5e-09 2020-06-08 prsweb-phecode184-11-phelan-sioc-p-5e-09-mgi-20200608 prsweb-phecode184-11-phelan-sioc-p-5e-09-mgi-20200608 PRSWEB_PHECODE184.11_Phelan-SIOC_P_5e-09_MGI_20200608 P_5e-09 PRSWEB_PHECODE184.11_Phelan-SIOC_P_5e-09_MGI_20200608 184.11 Serous invasive ovarian cancer Binary Serous invasive ovarian cancer MGI Michigan Genomics Initiative Fixed threshold (5e-09) Phelan CM et al. 2017 28346442 https://www.ncbi.nlm.nih.gov/pubmed/?term=28346442 19 0.029 0.000547148 0.0827 0.552 0.506-0.595 OR 1.36 0.349-5.29 1.36 0.349-5.29 1.27 0.467-3.47 1.27 0.467-3.47 1.44 0.776-2.66 1.44 0.776-2.66 1.54 0.982-2.41 1.54 0.982-2.41 1.56 1.12-2.17 1.56 1.12-2.17 1.73 1.08-2.77 0.0222 1.17 0.707-1.93 0.544 2 1.26-3.15 0.00308 TRUE FALSE FALSE FALSE Female 174 1730 GRCh37/hg19 P<=5e-09 2020-06-08 prsweb-phecode184-11-gwas-catalog-r2019-05-03-x184-11-p-5e-08-mgi-20200608 prsweb-phecode184-11-gwas-catalog-r2019-05-03-x184-11-p-5e-08-mgi-20200608 PRSWEB_PHECODE184.11_GWAS-Catalog-r2019-05-03-X184.11_P_5e-08_MGI_20200608 P_5e-08 PRSWEB_PHECODE184.11_GWAS-Catalog-r2019-05-03-X184.11_P_5e-08_MGI_20200608 184.11 Epithelial ovarian cancer;High-grade serous ovarian cancer;Serous invasive ovarian cancer;Invasive epithelial ovarian cancer;Mucinous ovarian carcinoma;Low-grade serous and serous borderline ovarian cancer;Serous borderline ovarian cancer;Ovarian cancer in BRCA1 mutation carriers;Ovarian cancer;Ovarian clear cell cancer Binary 32 unique SNPs MGI Michigan Genomics Initiative GWAS Hits GWAS Catalog (2019-05-03) 19648919;21964575;23544013;25581431;28346442 https://www.ncbi.nlm.nih.gov/pubmed/?term=19648919+21964575+23544013+25581431+28346442 21 0.17 0.00277694 0.0829 0.533 0.485-0.58 OR 1.37 0.351-5.34 1.37 0.351-5.34 0.997 0.325-3.06 0.997 0.325-3.06 1.09 0.547-2.17 1.09 0.547-2.17 1.08 0.648-1.79 1.08 0.648-1.79 1.36 0.974-1.91 1.36 0.974-1.91 0.88 0.541-1.43 0.607 1.37 0.876-2.13 0.168 1.5 0.972-2.33 0.0666 FALSE FALSE FALSE FALSE Female 174 1730 GRCh37/hg19 P<=5e-08 2020-06-08 prsweb-phecode184-11-phelan-epoc-p-5e-08-mgi-20200608 prsweb-phecode184-11-phelan-epoc-p-5e-08-mgi-20200608 PRSWEB_PHECODE184.11_Phelan-EPOC_P_5e-08_MGI_20200608 P_5e-08 PRSWEB_PHECODE184.11_Phelan-EPOC_P_5e-08_MGI_20200608 184.11 Epithelial ovarian cancer Binary Epithelial ovarian cancer MGI Michigan Genomics Initiative GWAS Hits Phelan CM et al. 2017 28346442 https://www.ncbi.nlm.nih.gov/pubmed/?term=28346442 6 0.79 0.00365518 0.0829 0.506 0.461-0.551 OR 1.87 0.571-6.13 1.87 0.571-6.13 1.21 0.442-3.29 1.21 0.442-3.29 1.42 0.763-2.62 1.42 0.763-2.62 1.11 0.677-1.83 1.11 0.677-1.83 1.15 0.809-1.62 1.15 0.809-1.62 1.23 0.8-1.9 0.342 0.938 0.592-1.49 0.786 1.17 0.757-1.8 0.483 FALSE FALSE FALSE FALSE Female 174 1730 GRCh37/hg19 P<=5e-08 2020-06-08 prsweb-phecode184-11-phelan-ieoc-p-5e-08-mgi-20200608 prsweb-phecode184-11-phelan-ieoc-p-5e-08-mgi-20200608 PRSWEB_PHECODE184.11_Phelan-IEOC_P_5e-08_MGI_20200608 P_5e-08 PRSWEB_PHECODE184.11_Phelan-IEOC_P_5e-08_MGI_20200608 184.11 Invasive epithelial ovarian cancer Binary Invasive epithelial ovarian cancer MGI Michigan Genomics Initiative GWAS Hits Phelan CM et al. 2017 28346442 https://www.ncbi.nlm.nih.gov/pubmed/?term=28346442 16 0.079 0.00036208 0.0828 0.542 0.495-0.587 OR 0.787 0.143-4.35 0.787 0.143-4.35 0.691 0.188-2.55 0.691 0.188-2.55 1.46 0.787-2.7 1.46 0.787-2.7 1.32 0.826-2.11 1.32 0.826-2.11 1.51 1.08-2.1 1.51 1.08-2.1 1.26 0.796-2 0.323 1.08 0.674-1.73 0.751 1.61 1.04-2.49 0.0318 FALSE FALSE FALSE FALSE Female 174 1730 GRCh37/hg19 P<=5e-08 2020-06-08 prsweb-phecode184-11-phelan-lsasboc-p-5e-08-mgi-20200608 prsweb-phecode184-11-phelan-lsasboc-p-5e-08-mgi-20200608 PRSWEB_PHECODE184.11_Phelan-LSASBOC_P_5e-08_MGI_20200608 P_5e-08 PRSWEB_PHECODE184.11_Phelan-LSASBOC_P_5e-08_MGI_20200608 184.11 Low-grade serous and serous borderline ovarian cancer Binary Low-grade serous and serous borderline ovarian cancer MGI Michigan Genomics Initiative GWAS Hits Phelan CM et al. 2017 28346442 https://www.ncbi.nlm.nih.gov/pubmed/?term=28346442 10 0.67 0.00636302 0.0829 0.517 0.467-0.562 OR 0.802 0.145-4.42 0.802 0.145-4.42 0.419 0.0802-2.19 0.419 0.0802-2.19 1.07 0.539-2.14 1.07 0.539-2.14 1.25 0.778-2.02 1.25 0.778-2.02 1.29 0.915-1.81 1.29 0.915-1.81 0.734 0.468-1.15 0.178 0.816 0.527-1.26 0.362 1.08 0.716-1.63 0.715 FALSE FALSE FALSE FALSE Female 174 1730 GRCh37/hg19 P<=5e-08 2020-06-08 prsweb-phecode184-11-phelan-mcoc-p-5e-08-mgi-20200608 prsweb-phecode184-11-phelan-mcoc-p-5e-08-mgi-20200608 PRSWEB_PHECODE184.11_Phelan-MCOC_P_5e-08_MGI_20200608 P_5e-08 PRSWEB_PHECODE184.11_Phelan-MCOC_P_5e-08_MGI_20200608 184.11 Mucinous ovarian carcinoma Binary Mucinous ovarian carcinoma MGI Michigan Genomics Initiative GWAS Hits Phelan CM et al. 2017 28346442 https://www.ncbi.nlm.nih.gov/pubmed/?term=28346442 5 0.27 0.000700944 0.0829 0.522 0.474-0.567 OR 2.46 0.848-7.13 2.46 0.848-7.13 1.86 0.785-4.39 1.86 0.785-4.39 1.83 1.04-3.21 1.83 1.04-3.21 1.6 1.03-2.49 1.6 1.03-2.49 1.24 0.883-1.75 1.24 0.883-1.75 1.23 0.784-1.93 0.366 1.13 0.712-1.79 0.61 1.35 0.867-2.09 0.185 FALSE FALSE FALSE FALSE Female 174 1730 GRCh37/hg19 P<=5e-08 2020-06-08 prsweb-phecode184-11-phelan-sioc-p-5e-08-mgi-20200608 prsweb-phecode184-11-phelan-sioc-p-5e-08-mgi-20200608 PRSWEB_PHECODE184.11_Phelan-SIOC_P_5e-08_MGI_20200608 P_5e-08 PRSWEB_PHECODE184.11_Phelan-SIOC_P_5e-08_MGI_20200608 184.11 Serous invasive ovarian cancer Binary Serous invasive ovarian cancer MGI Michigan Genomics Initiative GWAS Hits Phelan CM et al. 2017 28346442 https://www.ncbi.nlm.nih.gov/pubmed/?term=28346442 21 0.031 0.000215534 0.0827 0.554 0.509-0.597 OR 0.784 0.142-4.32 0.784 0.142-4.32 0.969 0.316-2.97 0.969 0.316-2.97 1.2 0.617-2.31 1.2 0.617-2.31 1.75 1.14-2.7 1.75 1.14-2.7 1.55 1.11-2.16 1.55 1.11-2.16 1.73 1.08-2.77 0.0215 1.16 0.701-1.91 0.569 2.02 1.28-3.2 0.00259 TRUE FALSE FALSE TRUE Female 174 1730 GRCh37/hg19 P<=5e-08 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000559/ScoringFiles/ phewas/PRSWEB_PHECODE184.11_Phelan-SIOC_P_5e-08_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE184.11_Phelan-SIOC_P_5e-08_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode184-11-20001-1039-pt-mgi-20200608 prsweb-phecode184-11-20001-1039-pt-mgi-20200608 PRSWEB_PHECODE184.11_20001-1039_PT_MGI_20200608 P&T PRSWEB_PHECODE184.11_20001-1039_PT_MGI_20200608 184.11 Cancer code, self-reported: ovarian cancer Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative P&T UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 34 0.22 0.00373365 0.0829 0.518 0.473-0.562 OR 1.3 0.334-5.07 1.3 0.334-5.07 1.78 0.754-4.22 1.78 0.754-4.22 1.41 0.757-2.61 1.41 0.757-2.61 1.23 0.762-1.99 1.23 0.762-1.99 1.18 0.833-1.66 1.18 0.833-1.66 0.852 0.535-1.36 0.5 1.21 0.788-1.87 0.38 1.21 0.784-1.86 0.39 FALSE FALSE FALSE FALSE Female 174 1730 GRCh37/hg19 P<=1.58e-05 2020-06-08 prsweb-phecode184-11-c3-ovary-pt-mgi-20200608 prsweb-phecode184-11-c3-ovary-pt-mgi-20200608 PRSWEB_PHECODE184.11_C3-OVARY_PT_MGI_20200608 P&T PRSWEB_PHECODE184.11_C3-OVARY_PT_MGI_20200608 184.11 Malignant neoplasm of ovary Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative P&T UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 193 0.53 0.000915249 0.0829 0.513 0.469-0.556 OR 0.826 0.15-4.56 0.826 0.15-4.56 0.993 0.325-3.04 0.993 0.325-3.04 0.958 0.465-1.97 0.958 0.465-1.97 0.99 0.59-1.66 0.99 0.59-1.66 1.09 0.765-1.54 1.09 0.765-1.54 1.11 0.71-1.73 0.652 1.15 0.737-1.79 0.542 1.18 0.756-1.83 0.472 FALSE FALSE FALSE FALSE Female 174 1730 GRCh37/hg19 P<=9.99e-05 2020-06-08 prsweb-phecode184-11-c56-pt-mgi-20200608 prsweb-phecode184-11-c56-pt-mgi-20200608 PRSWEB_PHECODE184.11_C56_PT_MGI_20200608 P&T PRSWEB_PHECODE184.11_C56_PT_MGI_20200608 184.11 Diagnoses - main ICD10: C56 Malignant neoplasm of ovary Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative P&T UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 14 0.18 0.00163533 0.0828 0.519 0.475-0.563 OR 1.91 0.587-6.22 1.91 0.587-6.22 1.28 0.469-3.49 1.28 0.469-3.49 1.35 0.713-2.55 1.35 0.713-2.55 1.25 0.778-2.02 1.25 0.778-2.02 1.18 0.834-1.66 1.18 0.834-1.66 0.918 0.571-1.48 0.726 1.45 0.936-2.24 0.0967 1.33 0.856-2.07 0.204 FALSE FALSE FALSE FALSE Female 174 1730 GRCh37/hg19 P<=7.94e-06 2020-06-08 prsweb-phecode184-11-gwas-catalog-r2019-05-03-x184-11-pt-mgi-20200608 prsweb-phecode184-11-gwas-catalog-r2019-05-03-x184-11-pt-mgi-20200608 PRSWEB_PHECODE184.11_GWAS-Catalog-r2019-05-03-X184.11_PT_MGI_20200608 P&T PRSWEB_PHECODE184.11_GWAS-Catalog-r2019-05-03-X184.11_PT_MGI_20200608 184.11 Epithelial ovarian cancer;High-grade serous ovarian cancer;Serous invasive ovarian cancer;Invasive epithelial ovarian cancer;Mucinous ovarian carcinoma;Low-grade serous and serous borderline ovarian cancer;Serous borderline ovarian cancer;Ovarian cancer in BRCA1 mutation carriers;Ovarian cancer;Ovarian clear cell cancer Binary 32 unique SNPs MGI Michigan Genomics Initiative P&T GWAS Catalog (2019-05-03) 19648919;21964575;23544013;25581431;28346442 https://www.ncbi.nlm.nih.gov/pubmed/?term=19648919+21964575+23544013+25581431+28346442 10 0.6 0.00611158 0.0829 0.505 0.459-0.549 OR 0.799 0.145-4.41 0.799 0.145-4.41 0.69 0.187-2.54 0.69 0.187-2.54 1.19 0.613-2.3 1.19 0.613-2.3 1.13 0.689-1.86 1.13 0.689-1.86 0.991 0.692-1.42 0.991 0.692-1.42 1.4 0.891-2.21 0.144 1.43 0.907-2.24 0.124 1.26 0.791-1.99 0.335 FALSE FALSE FALSE FALSE Female 174 1730 GRCh37/hg19 P<=5e-10 2020-06-08 prsweb-phecode184-11-phelan-epoc-pt-mgi-20200608 prsweb-phecode184-11-phelan-epoc-pt-mgi-20200608 PRSWEB_PHECODE184.11_Phelan-EPOC_PT_MGI_20200608 P&T PRSWEB_PHECODE184.11_Phelan-EPOC_PT_MGI_20200608 184.11 Epithelial ovarian cancer Binary Epithelial ovarian cancer MGI Michigan Genomics Initiative P&T Phelan CM et al. 2017 28346442 https://www.ncbi.nlm.nih.gov/pubmed/?term=28346442 5 0.75 0.00770036 0.0829 0.504 0.46-0.551 OR 1.9 0.582-6.23 1.9 0.582-6.23 1.26 0.459-3.46 1.26 0.459-3.46 1.16 0.599-2.25 1.16 0.599-2.25 1.39 0.874-2.2 1.39 0.874-2.2 1.05 0.737-1.5 1.05 0.737-1.5 0.85 0.549-1.32 0.467 0.891 0.578-1.37 0.599 0.939 0.614-1.44 0.773 FALSE FALSE FALSE FALSE Female 174 1730 GRCh37/hg19 P<=2e-10 2020-06-08 prsweb-phecode184-11-phelan-hsoc-pt-mgi-20200608 prsweb-phecode184-11-phelan-hsoc-pt-mgi-20200608 PRSWEB_PHECODE184.11_Phelan-HSOC_PT_MGI_20200608 P&T PRSWEB_PHECODE184.11_Phelan-HSOC_PT_MGI_20200608 184.11 High-grade serous ovarian cancer Binary High-grade serous ovarian cancer MGI Michigan Genomics Initiative P&T Phelan CM et al. 2017 28346442 https://www.ncbi.nlm.nih.gov/pubmed/?term=28346442 9 0.38 0.0014091 0.0829 0.52 0.48-0.56 OR 0.774 0.14-4.27 0.774 0.14-4.27 0.957 0.313-2.93 0.957 0.313-2.93 0.606 0.252-1.45 0.606 0.252-1.45 0.937 0.552-1.59 0.937 0.552-1.59 1.24 0.884-1.75 1.24 0.884-1.75 1.38 0.898-2.12 0.141 0.777 0.479-1.26 0.306 1.27 0.819-1.96 0.289 FALSE FALSE FALSE FALSE Female 174 1730 GRCh37/hg19 P<=3.98e-06 2020-06-08 prsweb-phecode184-11-phelan-ieoc-pt-mgi-20200608 prsweb-phecode184-11-phelan-ieoc-pt-mgi-20200608 PRSWEB_PHECODE184.11_Phelan-IEOC_PT_MGI_20200608 P&T PRSWEB_PHECODE184.11_Phelan-IEOC_PT_MGI_20200608 184.11 Invasive epithelial ovarian cancer Binary Invasive epithelial ovarian cancer MGI Michigan Genomics Initiative P&T Phelan CM et al. 2017 28346442 https://www.ncbi.nlm.nih.gov/pubmed/?term=28346442 144 0.28 0.00147311 0.0829 0.535 0.495-0.577 OR 0 0-0 0 0-0 0.137 0.00818-2.29 0.137 0.00818-2.29 0.5 0.191-1.31 0.5 0.191-1.31 0.693 0.382-1.26 0.693 0.382-1.26 1.25 0.886-1.76 1.25 0.886-1.76 1.37 0.869-2.16 0.176 1.22 0.77-1.95 0.393 1.48 0.949-2.32 0.0837 FALSE FALSE FALSE FALSE Female 174 1730 GRCh37/hg19 P<=2.51e-05 2020-06-08 prsweb-phecode184-11-phelan-lsasboc-pt-mgi-20200608 prsweb-phecode184-11-phelan-lsasboc-pt-mgi-20200608 PRSWEB_PHECODE184.11_Phelan-LSASBOC_PT_MGI_20200608 P&T PRSWEB_PHECODE184.11_Phelan-LSASBOC_PT_MGI_20200608 184.11 Low-grade serous and serous borderline ovarian cancer Binary Low-grade serous and serous borderline ovarian cancer MGI Michigan Genomics Initiative P&T Phelan CM et al. 2017 28346442 https://www.ncbi.nlm.nih.gov/pubmed/?term=28346442 34 0.31 0.00952796 0.0829 0.527 0.485-0.569 OR 0 0-0 0 0-0 0.41 0.0786-2.14 0.41 0.0786-2.14 0.607 0.253-1.45 0.607 0.253-1.45 1.06 0.637-1.75 1.06 0.637-1.75 1.15 0.814-1.63 1.15 0.814-1.63 1.02 0.652-1.6 0.929 1.13 0.725-1.75 0.594 1.19 0.769-1.83 0.439 FALSE FALSE FALSE FALSE Female 174 1730 GRCh37/hg19 P<=6.31e-06 2020-06-08 prsweb-phecode184-11-phelan-lsoc-pt-mgi-20200608 prsweb-phecode184-11-phelan-lsoc-pt-mgi-20200608 PRSWEB_PHECODE184.11_Phelan-LSOC_PT_MGI_20200608 P&T PRSWEB_PHECODE184.11_Phelan-LSOC_PT_MGI_20200608 184.11 Low-grade serous ovarian cancer Binary Low-grade serous ovarian cancer MGI Michigan Genomics Initiative P&T Phelan CM et al. 2017 28346442 https://www.ncbi.nlm.nih.gov/pubmed/?term=28346442 176 0.58 0.00208921 0.0829 0.521 0.475-0.565 OR 0.792 0.143-4.38 0.792 0.143-4.38 0.688 0.187-2.53 0.688 0.187-2.53 0.829 0.387-1.78 0.829 0.387-1.78 0.921 0.542-1.57 0.921 0.542-1.57 1.2 0.854-1.7 1.2 0.854-1.7 1.14 0.729-1.79 0.56 1.14 0.726-1.78 0.573 1.25 0.807-1.94 0.315 FALSE FALSE FALSE FALSE Female 174 1730 GRCh37/hg19 P<=9.99e-05 2020-06-08 prsweb-phecode184-11-phelan-mcoc-pt-mgi-20200608 prsweb-phecode184-11-phelan-mcoc-pt-mgi-20200608 PRSWEB_PHECODE184.11_Phelan-MCOC_PT_MGI_20200608 P&T PRSWEB_PHECODE184.11_Phelan-MCOC_PT_MGI_20200608 184.11 Mucinous ovarian carcinoma Binary Mucinous ovarian carcinoma MGI Michigan Genomics Initiative P&T Phelan CM et al. 2017 28346442 https://www.ncbi.nlm.nih.gov/pubmed/?term=28346442 254 0.72 0.00541796 0.0829 0.509 0.463-0.554 OR 1.84 0.564-5.98 1.84 0.564-5.98 1.53 0.608-3.84 1.53 0.608-3.84 1.3 0.69-2.46 1.3 0.69-2.46 1.18 0.725-1.92 1.18 0.725-1.92 1.08 0.76-1.54 1.08 0.76-1.54 0.857 0.548-1.34 0.498 0.98 0.636-1.51 0.925 1.02 0.664-1.56 0.934 FALSE FALSE FALSE FALSE Female 174 1730 GRCh37/hg19 P<=1e-04 2020-06-08 prsweb-phecode184-11-phelan-sioc-pt-mgi-20200608 prsweb-phecode184-11-phelan-sioc-pt-mgi-20200608 PRSWEB_PHECODE184.11_Phelan-SIOC_PT_MGI_20200608 P&T PRSWEB_PHECODE184.11_Phelan-SIOC_PT_MGI_20200608 184.11 Serous invasive ovarian cancer Binary Serous invasive ovarian cancer MGI Michigan Genomics Initiative P&T Phelan CM et al. 2017 28346442 https://www.ncbi.nlm.nih.gov/pubmed/?term=28346442 104 0.28 0.00678385 0.0829 0.528 0.486-0.569 OR 0.783 0.142-4.32 0.783 0.142-4.32 0.677 0.184-2.5 0.677 0.184-2.5 0.606 0.253-1.46 0.606 0.253-1.46 0.939 0.553-1.59 0.939 0.553-1.59 1.06 0.746-1.51 1.06 0.746-1.51 1.22 0.774-1.94 0.387 1.4 0.897-2.19 0.138 1.29 0.818-2.04 0.273 FALSE FALSE FALSE FALSE Female 174 1730 GRCh37/hg19 P<=1.58e-05 2020-06-08 prsweb-phecode184-11-20001-1039-prs-cs-mgi-20200608 prsweb-phecode184-11-20001-1039-prs-cs-mgi-20200608 PRSWEB_PHECODE184.11_20001-1039_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE184.11_20001-1039_PRS-CS_MGI_20200608 184.11 Cancer code, self-reported: ovarian cancer Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative PRS-CS UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1082696 0.22 0.000358723 0.0829 0.529 0.483-0.57 OR 0.737 0.133-4.07 0.737 0.133-4.07 0.924 0.301-2.83 0.924 0.301-2.83 1.05 0.524-2.09 1.05 0.524-2.09 1.24 0.772-2.01 1.24 0.772-2.01 1.24 0.88-1.74 1.24 0.88-1.74 1.05 0.671-1.66 0.82 1.03 0.657-1.61 0.903 1.27 0.828-1.95 0.271 FALSE FALSE FALSE FALSE Female 174 1730 GRCh37/hg19 auto 2020-06-08 prsweb-phecode184-11-c3-ovary-prs-cs-mgi-20200608 prsweb-phecode184-11-c3-ovary-prs-cs-mgi-20200608 PRSWEB_PHECODE184.11_C3-OVARY_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE184.11_C3-OVARY_PRS-CS_MGI_20200608 184.11 Malignant neoplasm of ovary Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative PRS-CS UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1095247 0.4 0.00274019 0.0829 0.525 0.478-0.568 OR 1.26 0.323-4.94 1.26 0.323-4.94 1.21 0.444-3.32 1.21 0.444-3.32 1.43 0.775-2.66 1.43 0.775-2.66 1.12 0.685-1.85 1.12 0.685-1.85 1.25 0.89-1.76 1.25 0.89-1.76 1.03 0.657-1.61 0.898 1.04 0.664-1.63 0.868 1.25 0.81-1.92 0.317 FALSE FALSE FALSE FALSE Female 174 1730 GRCh37/hg19 auto 2020-06-08 prsweb-phecode184-11-c56-prs-cs-mgi-20200608 prsweb-phecode184-11-c56-prs-cs-mgi-20200608 PRSWEB_PHECODE184.11_C56_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE184.11_C56_PRS-CS_MGI_20200608 184.11 Diagnoses - main ICD10: C56 Malignant neoplasm of ovary Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative PRS-CS UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1091510 0.57 6.33438e-05 0.0829 0.518 0.474-0.56 OR 3.09 1.15-8.29 3.09 1.15-8.29 1.57 0.624-3.93 1.57 0.624-3.93 0.84 0.392-1.8 0.84 0.392-1.8 0.631 0.341-1.17 0.631 0.341-1.17 1.15 0.811-1.62 1.15 0.811-1.62 1.37 0.867-2.16 0.178 1.37 0.858-2.17 0.189 1.4 0.888-2.21 0.147 FALSE FALSE FALSE FALSE Female 174 1730 GRCh37/hg19 auto 2020-06-08 prsweb-phecode184-11-phelan-enoc-prs-cs-mgi-20200608 prsweb-phecode184-11-phelan-enoc-prs-cs-mgi-20200608 PRSWEB_PHECODE184.11_Phelan-ENOC_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE184.11_Phelan-ENOC_PRS-CS_MGI_20200608 184.11 Endometrioid ovarian cancer Binary Endometrioid ovarian cancer MGI Michigan Genomics Initiative PRS-CS Phelan CM et al. 2017 28346442 https://www.ncbi.nlm.nih.gov/pubmed/?term=28346442 1114056 0.41 3.26737e-06 0.0829 0.523 0.479-0.573 OR 2.49 0.858-7.24 2.49 0.858-7.24 1.6 0.635-4.03 1.6 0.635-4.03 1.57 0.864-2.85 1.57 0.864-2.85 1.13 0.688-1.85 1.13 0.688-1.85 1.15 0.812-1.63 1.15 0.812-1.63 0.773 0.485-1.23 0.277 1.12 0.729-1.71 0.61 1.1 0.718-1.69 0.658 FALSE FALSE FALSE FALSE Female 174 1730 GRCh37/hg19 auto 2020-06-08 prsweb-phecode184-11-phelan-ieoc-prs-cs-mgi-20200608 prsweb-phecode184-11-phelan-ieoc-prs-cs-mgi-20200608 PRSWEB_PHECODE184.11_Phelan-IEOC_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE184.11_Phelan-IEOC_PRS-CS_MGI_20200608 184.11 Invasive epithelial ovarian cancer Binary Invasive epithelial ovarian cancer MGI Michigan Genomics Initiative PRS-CS Phelan CM et al. 2017 28346442 https://www.ncbi.nlm.nih.gov/pubmed/?term=28346442 1114056 0.14 0.00196861 0.0828 0.537 0.494-0.582 OR 1.87 0.576-6.07 1.87 0.576-6.07 0.973 0.318-2.98 0.973 0.318-2.98 1.45 0.785-2.69 1.45 0.785-2.69 0.939 0.553-1.6 0.939 0.553-1.6 1.22 0.863-1.71 1.22 0.863-1.71 1.15 0.729-1.82 0.543 1.25 0.793-1.96 0.338 1.38 0.888-2.15 0.152 FALSE FALSE FALSE FALSE Female 174 1730 GRCh37/hg19 auto 2020-06-08 prsweb-phecode184-11-phelan-lsasboc-prs-cs-mgi-20200608 prsweb-phecode184-11-phelan-lsasboc-prs-cs-mgi-20200608 PRSWEB_PHECODE184.11_Phelan-LSASBOC_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE184.11_Phelan-LSASBOC_PRS-CS_MGI_20200608 184.11 Low-grade serous and serous borderline ovarian cancer Binary Low-grade serous and serous borderline ovarian cancer MGI Michigan Genomics Initiative PRS-CS Phelan CM et al. 2017 28346442 https://www.ncbi.nlm.nih.gov/pubmed/?term=28346442 1114056 0.36 0.000388824 0.0829 0.528 0.482-0.572 OR 1.36 0.348-5.29 1.36 0.348-5.29 0.701 0.191-2.58 0.701 0.191-2.58 0.716 0.318-1.61 0.716 0.318-1.61 0.985 0.587-1.65 0.985 0.587-1.65 1 0.703-1.44 1 0.703-1.44 1.15 0.723-1.84 0.551 1.46 0.947-2.27 0.0866 1.19 0.753-1.87 0.459 FALSE FALSE FALSE FALSE Female 174 1730 GRCh37/hg19 auto 2020-06-08 prsweb-phecode184-11-phelan-lsoc-prs-cs-mgi-20200608 prsweb-phecode184-11-phelan-lsoc-prs-cs-mgi-20200608 PRSWEB_PHECODE184.11_Phelan-LSOC_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE184.11_Phelan-LSOC_PRS-CS_MGI_20200608 184.11 Low-grade serous ovarian cancer Binary Low-grade serous ovarian cancer MGI Michigan Genomics Initiative PRS-CS Phelan CM et al. 2017 28346442 https://www.ncbi.nlm.nih.gov/pubmed/?term=28346442 1114046 0.71 0.000316528 0.0829 0.51 0.467-0.558 OR 2.38 0.819-6.89 2.38 0.819-6.89 1.25 0.458-3.4 1.25 0.458-3.4 1.07 0.536-2.13 1.07 0.536-2.13 0.746 0.419-1.33 0.746 0.419-1.33 0.958 0.668-1.38 0.958 0.668-1.38 0.964 0.612-1.52 0.874 1.32 0.86-2.02 0.205 1.04 0.663-1.62 0.873 FALSE FALSE FALSE FALSE Female 174 1730 GRCh37/hg19 auto 2020-06-08 prsweb-phecode184-11-phelan-mcoc-prs-cs-mgi-20200608 prsweb-phecode184-11-phelan-mcoc-prs-cs-mgi-20200608 PRSWEB_PHECODE184.11_Phelan-MCOC_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE184.11_Phelan-MCOC_PRS-CS_MGI_20200608 184.11 Mucinous ovarian carcinoma Binary Mucinous ovarian carcinoma MGI Michigan Genomics Initiative PRS-CS Phelan CM et al. 2017 28346442 https://www.ncbi.nlm.nih.gov/pubmed/?term=28346442 1114056 0.7 6.51556e-05 0.0829 0.507 0.462-0.553 OR 1.3 0.333-5.07 1.3 0.333-5.07 0.938 0.305-2.88 0.938 0.305-2.88 1.16 0.599-2.26 1.16 0.599-2.26 1.37 0.865-2.18 1.37 0.865-2.18 0.893 0.619-1.29 0.893 0.619-1.29 1.34 0.866-2.07 0.19 1.19 0.762-1.87 0.441 1.02 0.647-1.62 0.925 FALSE FALSE FALSE FALSE Female 174 1730 GRCh37/hg19 auto 2020-06-08 prsweb-phecode184-11-phelan-sioc-prs-cs-mgi-20200608 prsweb-phecode184-11-phelan-sioc-prs-cs-mgi-20200608 PRSWEB_PHECODE184.11_Phelan-SIOC_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE184.11_Phelan-SIOC_PRS-CS_MGI_20200608 184.11 Serous invasive ovarian cancer Binary Serous invasive ovarian cancer MGI Michigan Genomics Initiative PRS-CS Phelan CM et al. 2017 28346442 https://www.ncbi.nlm.nih.gov/pubmed/?term=28346442 1114056 0.036 0.00189205 0.0827 0.552 0.513-0.598 OR 0 0-0 0 0-0 0.69 0.187-2.54 0.69 0.187-2.54 1.69 0.949-3.02 1.69 0.949-3.02 1.33 0.829-2.12 1.33 0.829-2.12 1.42 1.02-1.98 1.42 1.02-1.98 1.36 0.853-2.18 0.196 1.28 0.798-2.06 0.304 1.72 1.1-2.7 0.0177 TRUE FALSE FALSE TRUE Female 174 1730 GRCh37/hg19 auto https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000561/ScoringFiles/ phewas/PRSWEB_PHECODE184.11_Phelan-SIOC_PRS-CS_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE184.11_Phelan-SIOC_PRS-CS_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode184-11-20001-1039-lassosum-mgi-20200608 prsweb-phecode184-11-20001-1039-lassosum-mgi-20200608 PRSWEB_PHECODE184.11_20001-1039_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE184.11_20001-1039_LASSOSUM_MGI_20200608 184.11 Cancer code, self-reported: ovarian cancer Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative lassosum UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 214 0.17 0.00181022 0.0829 0.531 0.485-0.573 OR 4.14 1.72-9.98 4.14 1.72-9.98 2.76 1.32-5.8 2.76 1.32-5.8 1.31 0.693-2.48 1.31 0.693-2.48 1.12 0.683-1.84 1.12 0.683-1.84 1.02 0.716-1.46 1.02 0.716-1.46 1.33 0.835-2.11 0.231 1.63 1.04-2.56 0.0343 1.35 0.847-2.15 0.207 FALSE FALSE FALSE FALSE Female 174 1730 GRCh37/hg19 s=0.2;Lambda=0.07848 2020-06-08 prsweb-phecode184-11-c56-lassosum-mgi-20200608 prsweb-phecode184-11-c56-lassosum-mgi-20200608 PRSWEB_PHECODE184.11_C56_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE184.11_C56_LASSOSUM_MGI_20200608 184.11 Diagnoses - main ICD10: C56 Malignant neoplasm of ovary Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative lassosum UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 49464 0.94 0.000902898 0.0829 0.499 0.457-0.54 OR 0.82 0.148-4.54 0.82 0.148-4.54 0.422 0.0805-2.21 0.422 0.0805-2.21 0.967 0.469-1.99 0.967 0.469-1.99 0.875 0.508-1.51 0.875 0.508-1.51 0.876 0.605-1.27 0.876 0.605-1.27 1.5 0.972-2.31 0.0673 1.18 0.746-1.85 0.485 1.04 0.652-1.64 0.882 FALSE FALSE FALSE FALSE Female 174 1730 GRCh37/hg19 s=0.2;Lambda=0.03793 2020-06-08 prsweb-phecode184-11-phelan-epoc-lassosum-mgi-20200608 prsweb-phecode184-11-phelan-epoc-lassosum-mgi-20200608 PRSWEB_PHECODE184.11_Phelan-EPOC_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE184.11_Phelan-EPOC_LASSOSUM_MGI_20200608 184.11 Epithelial ovarian cancer Binary Epithelial ovarian cancer MGI Michigan Genomics Initiative lassosum Phelan CM et al. 2017 28346442 https://www.ncbi.nlm.nih.gov/pubmed/?term=28346442 59 0.36 0.00562222 0.0829 0.552 0.511-0.593 OR 0 0-0 0 0-0 0.412 0.0787-2.16 0.412 0.0787-2.16 0.834 0.388-1.79 0.834 0.388-1.79 1.05 0.636-1.75 1.05 0.636-1.75 1.18 0.839-1.67 1.18 0.839-1.67 1.13 0.721-1.78 0.592 1.13 0.719-1.77 0.596 1.3 0.836-2.02 0.246 FALSE FALSE FALSE FALSE Female 174 1730 GRCh37/hg19 s=1;Lambda=0.02336 2020-06-08 prsweb-phecode184-11-phelan-hsoc-lassosum-mgi-20200608 prsweb-phecode184-11-phelan-hsoc-lassosum-mgi-20200608 PRSWEB_PHECODE184.11_Phelan-HSOC_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE184.11_Phelan-HSOC_LASSOSUM_MGI_20200608 184.11 High-grade serous ovarian cancer Binary High-grade serous ovarian cancer MGI Michigan Genomics Initiative lassosum Phelan CM et al. 2017 28346442 https://www.ncbi.nlm.nih.gov/pubmed/?term=28346442 20012 0.42 0.00490468 0.0829 0.516 0.475-0.56 OR 0.824 0.149-4.55 0.824 0.149-4.55 0.693 0.189-2.55 0.693 0.189-2.55 0.723 0.321-1.63 0.723 0.321-1.63 0.812 0.465-1.42 0.812 0.465-1.42 0.815 0.56-1.19 0.815 0.56-1.19 1.67 1.06-2.64 0.0269 1.67 1.05-2.63 0.0287 1.18 0.726-1.92 0.502 FALSE FALSE FALSE FALSE Female 174 1730 GRCh37/hg19 s=0.9;Lambda=0.01438 2020-06-08 prsweb-phecode184-11-phelan-lsasboc-lassosum-mgi-20200608 prsweb-phecode184-11-phelan-lsasboc-lassosum-mgi-20200608 PRSWEB_PHECODE184.11_Phelan-LSASBOC_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE184.11_Phelan-LSASBOC_LASSOSUM_MGI_20200608 184.11 Low-grade serous and serous borderline ovarian cancer Binary Low-grade serous and serous borderline ovarian cancer MGI Michigan Genomics Initiative lassosum Phelan CM et al. 2017 28346442 https://www.ncbi.nlm.nih.gov/pubmed/?term=28346442 5328 0.061 0.00907415 0.0827 0.544 0.497-0.589 OR 2.32 0.796-6.76 2.32 0.796-6.76 2.05 0.908-4.64 2.05 0.908-4.64 1.07 0.536-2.12 1.07 0.536-2.12 1.13 0.688-1.85 1.13 0.688-1.85 1.25 0.89-1.77 1.25 0.89-1.77 1.13 0.707-1.8 0.615 1.38 0.881-2.17 0.159 1.39 0.892-2.18 0.145 FALSE FALSE FALSE FALSE Female 174 1730 GRCh37/hg19 s=0.5;Lambda=0.02976 2020-06-08 prsweb-phecode184-11-phelan-occc-lassosum-mgi-20200608 prsweb-phecode184-11-phelan-occc-lassosum-mgi-20200608 PRSWEB_PHECODE184.11_Phelan-OCCC_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE184.11_Phelan-OCCC_LASSOSUM_MGI_20200608 184.11 Ovarian clear cell cancer Binary Ovarian clear cell cancer MGI Michigan Genomics Initiative lassosum Phelan CM et al. 2017 28346442 https://www.ncbi.nlm.nih.gov/pubmed/?term=28346442 3387 0.074 0.00683928 0.0828 0.539 0.495-0.586 OR 3.04 1.13-8.13 3.04 1.13-8.13 2.46 1.14-5.34 2.46 1.14-5.34 1.6 0.882-2.92 1.6 0.882-2.92 1.57 1-2.46 1.57 1-2.46 1.33 0.946-1.86 1.33 0.946-1.86 0.783 0.481-1.28 0.326 1.36 0.881-2.09 0.166 1.37 0.893-2.11 0.148 FALSE FALSE FALSE FALSE Female 174 1730 GRCh37/hg19 s=1;Lambda=0.04833 2020-06-08 prsweb-phecode184-11-gwas-catalog-r2019-05-03-x184-11-p-5e-05-ukb-20200608 prsweb-phecode184-11-gwas-catalog-r2019-05-03-x184-11-p-5e-05-ukb-20200608 PRSWEB_PHECODE184.11_GWAS-Catalog-r2019-05-03-X184.11_P_5e-05_UKB_20200608 P_5e-05 PRSWEB_PHECODE184.11_GWAS-Catalog-r2019-05-03-X184.11_P_5e-05_UKB_20200608 184.11 Epithelial ovarian cancer;High-grade serous ovarian cancer;Serous invasive ovarian cancer;Invasive epithelial ovarian cancer;Mucinous ovarian carcinoma;Low-grade serous and serous borderline ovarian cancer;Serous borderline ovarian cancer;Ovarian cancer in BRCA1 mutation carriers;Ovarian cancer;Ovarian clear cell cancer Binary 32 unique SNPs UKB UK Biobank Fixed threshold (5e-05) GWAS Catalog (2019-05-03) 19648919;21964575;23544013;25581431;28346442 https://www.ncbi.nlm.nih.gov/pubmed/?term=19648919+21964575+23544013+25581431+28346442 25 0.014 0.00071299 0.0827 0.532 0.504-0.561 OR 1.34 0.584-3.07 1.34 0.584-3.07 1.1 0.575-2.09 1.1 0.575-2.09 1.12 0.74-1.69 1.12 0.74-1.69 1.24 0.926-1.66 1.24 0.926-1.66 1.23 0.994-1.51 1.23 0.994-1.51 0.971 0.728-1.29 0.838 1.36 1.04-1.77 0.0261 1.34 1.03-1.75 0.0322 TRUE FALSE FALSE FALSE Female 473 4723 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode184-11-phelan-enoc-p-5e-05-ukb-20200608 prsweb-phecode184-11-phelan-enoc-p-5e-05-ukb-20200608 PRSWEB_PHECODE184.11_Phelan-ENOC_P_5e-05_UKB_20200608 P_5e-05 PRSWEB_PHECODE184.11_Phelan-ENOC_P_5e-05_UKB_20200608 184.11 Endometrioid ovarian cancer Binary Endometrioid ovarian cancer UKB UK Biobank Fixed threshold (5e-05) Phelan CM et al. 2017 28346442 https://www.ncbi.nlm.nih.gov/pubmed/?term=28346442 98 0.74 3.99076e-05 0.0827 0.508 0.483-0.533 OR 0.716 0.239-2.15 0.716 0.239-2.15 0.569 0.239-1.35 0.569 0.239-1.35 0.681 0.409-1.13 0.681 0.409-1.13 1.05 0.768-1.43 1.05 0.768-1.43 0.944 0.757-1.18 0.944 0.757-1.18 1.11 0.846-1.45 0.455 1.21 0.929-1.58 0.157 1.05 0.796-1.38 0.742 FALSE FALSE FALSE FALSE Female 473 4723 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode184-11-phelan-epoc-p-5e-05-ukb-20200608 prsweb-phecode184-11-phelan-epoc-p-5e-05-ukb-20200608 PRSWEB_PHECODE184.11_Phelan-EPOC_P_5e-05_UKB_20200608 P_5e-05 PRSWEB_PHECODE184.11_Phelan-EPOC_P_5e-05_UKB_20200608 184.11 Epithelial ovarian cancer Binary Epithelial ovarian cancer UKB UK Biobank Fixed threshold (5e-05) Phelan CM et al. 2017 28346442 https://www.ncbi.nlm.nih.gov/pubmed/?term=28346442 111 0.96 0.00295605 0.0827 0.5 0.472-0.529 OR 1.13 0.463-2.76 1.13 0.463-2.76 1.1 0.575-2.09 1.1 0.575-2.09 1.21 0.809-1.8 1.21 0.809-1.8 1.14 0.846-1.54 1.14 0.846-1.54 1.08 0.872-1.34 1.08 0.872-1.34 0.941 0.722-1.22 0.65 0.858 0.655-1.12 0.266 1.01 0.779-1.31 0.94 FALSE FALSE FALSE FALSE Female 473 4723 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode184-11-phelan-hsoc-p-5e-05-ukb-20200608 prsweb-phecode184-11-phelan-hsoc-p-5e-05-ukb-20200608 PRSWEB_PHECODE184.11_Phelan-HSOC_P_5e-05_UKB_20200608 P_5e-05 PRSWEB_PHECODE184.11_Phelan-HSOC_P_5e-05_UKB_20200608 184.11 High-grade serous ovarian cancer Binary High-grade serous ovarian cancer UKB UK Biobank Fixed threshold (5e-05) Phelan CM et al. 2017 28346442 https://www.ncbi.nlm.nih.gov/pubmed/?term=28346442 116 0.00094 0.000753451 0.0826 0.543 0.516-0.57 OR 0.923 0.347-2.45 0.923 0.347-2.45 1.31 0.72-2.39 1.31 0.72-2.39 1.39 0.951-2.03 1.39 0.951-2.03 1.47 1.11-1.93 1.47 1.11-1.93 1.32 1.07-1.62 1.32 1.07-1.62 1.35 1.02-1.78 0.0369 1.23 0.926-1.64 0.152 1.58 1.2-2.08 0.001 TRUE FALSE FALSE FALSE Female 473 4723 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode184-11-phelan-ieoc-p-5e-05-ukb-20200608 prsweb-phecode184-11-phelan-ieoc-p-5e-05-ukb-20200608 PRSWEB_PHECODE184.11_Phelan-IEOC_P_5e-05_UKB_20200608 P_5e-05 PRSWEB_PHECODE184.11_Phelan-IEOC_P_5e-05_UKB_20200608 184.11 Invasive epithelial ovarian cancer Binary Invasive epithelial ovarian cancer UKB UK Biobank Fixed threshold (5e-05) Phelan CM et al. 2017 28346442 https://www.ncbi.nlm.nih.gov/pubmed/?term=28346442 219 0.016 0.00385697 0.0826 0.532 0.506-0.559 OR 2.39 1.24-4.61 2.39 1.24-4.61 1.64 0.946-2.83 1.64 0.946-2.83 1.3 0.879-1.92 1.3 0.879-1.92 1.24 0.926-1.66 1.24 0.926-1.66 1.3 1.06-1.6 1.3 1.06-1.6 1.12 0.846-1.48 0.427 1.2 0.907-1.58 0.204 1.44 1.11-1.89 0.00704 TRUE FALSE FALSE FALSE Female 473 4723 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode184-11-phelan-lsasboc-p-5e-05-ukb-20200608 prsweb-phecode184-11-phelan-lsasboc-p-5e-05-ukb-20200608 PRSWEB_PHECODE184.11_Phelan-LSASBOC_P_5e-05_UKB_20200608 P_5e-05 PRSWEB_PHECODE184.11_Phelan-LSASBOC_P_5e-05_UKB_20200608 184.11 Low-grade serous and serous borderline ovarian cancer Binary Low-grade serous and serous borderline ovarian cancer UKB UK Biobank Fixed threshold (5e-05) Phelan CM et al. 2017 28346442 https://www.ncbi.nlm.nih.gov/pubmed/?term=28346442 146 0.79 0.00164366 0.0827 0.51 0.483-0.538 OR 0.717 0.239-2.15 0.717 0.239-2.15 0.779 0.367-1.65 0.779 0.367-1.65 0.941 0.604-1.47 0.941 0.604-1.47 1.14 0.847-1.54 1.14 0.847-1.54 1.18 0.952-1.45 1.18 0.952-1.45 1.07 0.82-1.4 0.609 0.949 0.721-1.25 0.71 1.19 0.912-1.54 0.203 FALSE FALSE FALSE FALSE Female 473 4723 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode184-11-phelan-occc-p-5e-05-ukb-20200608 prsweb-phecode184-11-phelan-occc-p-5e-05-ukb-20200608 PRSWEB_PHECODE184.11_Phelan-OCCC_P_5e-05_UKB_20200608 P_5e-05 PRSWEB_PHECODE184.11_Phelan-OCCC_P_5e-05_UKB_20200608 184.11 Ovarian clear cell cancer Binary Ovarian clear cell cancer UKB UK Biobank Fixed threshold (5e-05) Phelan CM et al. 2017 28346442 https://www.ncbi.nlm.nih.gov/pubmed/?term=28346442 100 0.14 0.0015819 0.0827 0.518 0.491-0.546 OR 1.34 0.584-3.07 1.34 0.584-3.07 1.2 0.647-2.24 1.2 0.647-2.24 1.48 1.02-2.15 1.48 1.02-2.15 1.29 0.966-1.72 1.29 0.966-1.72 1.06 0.852-1.31 1.06 0.852-1.31 1.34 1.02-1.76 0.033 1.15 0.868-1.51 0.334 1.24 0.939-1.63 0.13 FALSE FALSE FALSE FALSE Female 473 4723 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode184-11-phelan-sioc-p-5e-05-ukb-20200608 prsweb-phecode184-11-phelan-sioc-p-5e-05-ukb-20200608 PRSWEB_PHECODE184.11_Phelan-SIOC_P_5e-05_UKB_20200608 P_5e-05 PRSWEB_PHECODE184.11_Phelan-SIOC_P_5e-05_UKB_20200608 184.11 Serous invasive ovarian cancer Binary Serous invasive ovarian cancer UKB UK Biobank Fixed threshold (5e-05) Phelan CM et al. 2017 28346442 https://www.ncbi.nlm.nih.gov/pubmed/?term=28346442 207 0.0016 0.0031182 0.0826 0.539 0.512-0.565 OR 1.97 0.971-3.99 1.97 0.971-3.99 1.31 0.72-2.39 1.31 0.72-2.39 1.81 1.28-2.55 1.81 1.28-2.55 1.75 1.35-2.28 1.75 1.35-2.28 1.29 1.05-1.58 1.29 1.05-1.58 0.959 0.723-1.27 0.773 1.19 0.908-1.56 0.206 1.34 1.03-1.75 0.0289 TRUE FALSE FALSE FALSE Female 473 4723 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode184-11-gwas-catalog-r2019-05-03-x184-11-p-5e-06-ukb-20200608 prsweb-phecode184-11-gwas-catalog-r2019-05-03-x184-11-p-5e-06-ukb-20200608 PRSWEB_PHECODE184.11_GWAS-Catalog-r2019-05-03-X184.11_P_5e-06_UKB_20200608 P_5e-06 PRSWEB_PHECODE184.11_GWAS-Catalog-r2019-05-03-X184.11_P_5e-06_UKB_20200608 184.11 Epithelial ovarian cancer;High-grade serous ovarian cancer;Serous invasive ovarian cancer;Invasive epithelial ovarian cancer;Mucinous ovarian carcinoma;Low-grade serous and serous borderline ovarian cancer;Serous borderline ovarian cancer;Ovarian cancer in BRCA1 mutation carriers;Ovarian cancer;Ovarian clear cell cancer Binary 32 unique SNPs UKB UK Biobank Fixed threshold (5e-06) GWAS Catalog (2019-05-03) 19648919;21964575;23544013;25581431;28346442 https://www.ncbi.nlm.nih.gov/pubmed/?term=19648919+21964575+23544013+25581431+28346442 25 0.014 0.00071299 0.0827 0.532 0.504-0.561 OR 1.34 0.584-3.07 1.34 0.584-3.07 1.1 0.575-2.09 1.1 0.575-2.09 1.12 0.74-1.69 1.12 0.74-1.69 1.24 0.926-1.66 1.24 0.926-1.66 1.23 0.994-1.51 1.23 0.994-1.51 0.971 0.728-1.29 0.838 1.36 1.04-1.77 0.0261 1.34 1.03-1.75 0.0322 TRUE FALSE FALSE FALSE Female 473 4723 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode184-11-phelan-epoc-p-5e-06-ukb-20200608 prsweb-phecode184-11-phelan-epoc-p-5e-06-ukb-20200608 PRSWEB_PHECODE184.11_Phelan-EPOC_P_5e-06_UKB_20200608 P_5e-06 PRSWEB_PHECODE184.11_Phelan-EPOC_P_5e-06_UKB_20200608 184.11 Epithelial ovarian cancer Binary Epithelial ovarian cancer UKB UK Biobank Fixed threshold (5e-06) Phelan CM et al. 2017 28346442 https://www.ncbi.nlm.nih.gov/pubmed/?term=28346442 26 0.1 0.00357338 0.0827 0.532 0.506-0.557 OR 0.716 0.239-2.14 0.716 0.239-2.14 0.885 0.435-1.8 0.885 0.435-1.8 0.942 0.605-1.47 0.942 0.605-1.47 1.02 0.749-1.4 1.02 0.749-1.4 1.23 0.994-1.51 1.23 0.994-1.51 1.07 0.809-1.42 0.624 1.28 0.974-1.68 0.0766 1.37 1.05-1.8 0.021 FALSE FALSE FALSE FALSE Female 473 4723 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode184-11-phelan-ieoc-p-5e-06-ukb-20200608 prsweb-phecode184-11-phelan-ieoc-p-5e-06-ukb-20200608 PRSWEB_PHECODE184.11_Phelan-IEOC_P_5e-06_UKB_20200608 P_5e-06 PRSWEB_PHECODE184.11_Phelan-IEOC_P_5e-06_UKB_20200608 184.11 Invasive epithelial ovarian cancer Binary Invasive epithelial ovarian cancer UKB UK Biobank Fixed threshold (5e-06) Phelan CM et al. 2017 28346442 https://www.ncbi.nlm.nih.gov/pubmed/?term=28346442 54 3.8e-06 0.00257925 0.0824 0.566 0.538-0.594 OR 1.34 0.583-3.07 1.34 0.583-3.07 1.31 0.721-2.39 1.31 0.721-2.39 1.77 1.25-2.5 1.77 1.25-2.5 1.81 1.4-2.34 1.81 1.4-2.34 1.52 1.24-1.86 1.52 1.24-1.86 1.03 0.767-1.39 0.833 1.41 1.07-1.86 0.0162 1.74 1.33-2.28 5.45e-05 TRUE FALSE FALSE FALSE Female 473 4723 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode184-11-phelan-lsasboc-p-5e-06-ukb-20200608 prsweb-phecode184-11-phelan-lsasboc-p-5e-06-ukb-20200608 PRSWEB_PHECODE184.11_Phelan-LSASBOC_P_5e-06_UKB_20200608 P_5e-06 PRSWEB_PHECODE184.11_Phelan-LSASBOC_P_5e-06_UKB_20200608 184.11 Low-grade serous and serous borderline ovarian cancer Binary Low-grade serous and serous borderline ovarian cancer UKB UK Biobank Fixed threshold (5e-06) Phelan CM et al. 2017 28346442 https://www.ncbi.nlm.nih.gov/pubmed/?term=28346442 28 0.0054 0.00264586 0.0826 0.54 0.513-0.567 OR 1.97 0.971-4 1.97 0.971-4 2.19 1.34-3.57 2.19 1.34-3.57 1.62 1.13-2.32 1.62 1.13-2.32 1.41 1.07-1.87 1.41 1.07-1.87 1.24 1-1.52 1.24 1-1.52 1.14 0.861-1.5 0.365 1.17 0.884-1.54 0.277 1.36 1.04-1.78 0.0242 TRUE FALSE FALSE FALSE Female 473 4723 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode184-11-phelan-lsoc-p-5e-06-ukb-20200608 prsweb-phecode184-11-phelan-lsoc-p-5e-06-ukb-20200608 PRSWEB_PHECODE184.11_Phelan-LSOC_P_5e-06_UKB_20200608 P_5e-06 PRSWEB_PHECODE184.11_Phelan-LSOC_P_5e-06_UKB_20200608 184.11 Low-grade serous ovarian cancer Binary Low-grade serous ovarian cancer UKB UK Biobank Fixed threshold (5e-06) Phelan CM et al. 2017 28346442 https://www.ncbi.nlm.nih.gov/pubmed/?term=28346442 15 0.094 0.000114221 0.0827 0.521 0.493-0.547 OR 0.717 0.239-2.15 0.717 0.239-2.15 1.1 0.576-2.1 1.1 0.576-2.1 1.39 0.951-2.03 1.39 0.951-2.03 1.29 0.966-1.72 1.29 0.966-1.72 1.2 0.973-1.48 1.2 0.973-1.48 0.85 0.644-1.12 0.25 1.03 0.793-1.35 0.802 1.15 0.885-1.49 0.3 FALSE FALSE FALSE FALSE Female 473 4723 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode184-11-phelan-mcoc-p-5e-06-ukb-20200608 prsweb-phecode184-11-phelan-mcoc-p-5e-06-ukb-20200608 PRSWEB_PHECODE184.11_Phelan-MCOC_P_5e-06_UKB_20200608 P_5e-06 PRSWEB_PHECODE184.11_Phelan-MCOC_P_5e-06_UKB_20200608 184.11 Mucinous ovarian carcinoma Binary Mucinous ovarian carcinoma UKB UK Biobank Fixed threshold (5e-06) Phelan CM et al. 2017 28346442 https://www.ncbi.nlm.nih.gov/pubmed/?term=28346442 27 0.89 0.00336535 0.0827 0.503 0.477-0.528 OR 1.76 0.839-3.7 1.76 0.839-3.7 1.53 0.871-2.69 1.53 0.871-2.69 1.21 0.809-1.8 1.21 0.809-1.8 0.884 0.636-1.23 0.884 0.636-1.23 0.955 0.766-1.19 0.955 0.766-1.19 0.979 0.75-1.28 0.877 1.03 0.789-1.34 0.841 0.959 0.733-1.25 0.76 FALSE FALSE FALSE FALSE Female 473 4723 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode184-11-phelan-sioc-p-5e-06-ukb-20200608 prsweb-phecode184-11-phelan-sioc-p-5e-06-ukb-20200608 PRSWEB_PHECODE184.11_Phelan-SIOC_P_5e-06_UKB_20200608 P_5e-06 PRSWEB_PHECODE184.11_Phelan-SIOC_P_5e-06_UKB_20200608 184.11 Serous invasive ovarian cancer Binary Serous invasive ovarian cancer UKB UK Biobank Fixed threshold (5e-06) Phelan CM et al. 2017 28346442 https://www.ncbi.nlm.nih.gov/pubmed/?term=28346442 58 2.6e-05 0.00323656 0.0825 0.556 0.529-0.584 OR 1.55 0.709-3.38 1.55 0.709-3.38 1.97 1.18-3.27 1.97 1.18-3.27 1.62 1.13-2.32 1.62 1.13-2.32 1.36 1.03-1.81 1.36 1.03-1.81 1.4 1.14-1.71 1.4 1.14-1.71 1.03 0.765-1.38 0.852 1.48 1.12-1.95 0.00539 1.63 1.24-2.14 0.000408 TRUE FALSE FALSE FALSE Female 473 4723 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode184-11-gwas-catalog-r2019-05-03-x184-11-p-5e-07-ukb-20200608 prsweb-phecode184-11-gwas-catalog-r2019-05-03-x184-11-p-5e-07-ukb-20200608 PRSWEB_PHECODE184.11_GWAS-Catalog-r2019-05-03-X184.11_P_5e-07_UKB_20200608 P_5e-07 PRSWEB_PHECODE184.11_GWAS-Catalog-r2019-05-03-X184.11_P_5e-07_UKB_20200608 184.11 Epithelial ovarian cancer;High-grade serous ovarian cancer;Serous invasive ovarian cancer;Invasive epithelial ovarian cancer;Mucinous ovarian carcinoma;Low-grade serous and serous borderline ovarian cancer;Serous borderline ovarian cancer;Ovarian cancer in BRCA1 mutation carriers;Ovarian cancer;Ovarian clear cell cancer Binary 32 unique SNPs UKB UK Biobank Fixed threshold (5e-07) GWAS Catalog (2019-05-03) 19648919;21964575;23544013;25581431;28346442 https://www.ncbi.nlm.nih.gov/pubmed/?term=19648919+21964575+23544013+25581431+28346442 23 0.018 0.000777744 0.0827 0.531 0.502-0.559 OR 1.55 0.709-3.38 1.55 0.709-3.38 0.991 0.504-1.95 0.991 0.504-1.95 1.07 0.706-1.63 1.07 0.706-1.63 1.26 0.946-1.69 1.26 0.946-1.69 1.24 1.01-1.52 1.24 1.01-1.52 0.929 0.697-1.24 0.617 1.29 0.992-1.69 0.0574 1.31 1.01-1.71 0.0451 TRUE FALSE FALSE FALSE Female 473 4723 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode184-11-phelan-epoc-p-5e-07-ukb-20200608 prsweb-phecode184-11-phelan-epoc-p-5e-07-ukb-20200608 PRSWEB_PHECODE184.11_Phelan-EPOC_P_5e-07_UKB_20200608 P_5e-07 PRSWEB_PHECODE184.11_Phelan-EPOC_P_5e-07_UKB_20200608 184.11 Epithelial ovarian cancer Binary Epithelial ovarian cancer UKB UK Biobank Fixed threshold (5e-07) Phelan CM et al. 2017 28346442 https://www.ncbi.nlm.nih.gov/pubmed/?term=28346442 7 0.0084 0.00482005 0.0826 0.535 0.509-0.563 OR 1.29 0.562-2.94 1.29 0.562-2.94 1.42 0.813-2.49 1.42 0.813-2.49 1.45 1-2.1 1.45 1-2.1 1.36 1.03-1.8 1.36 1.03-1.8 1.24 1.01-1.53 1.24 1.01-1.53 1.26 0.959-1.65 0.0971 1.27 0.964-1.69 0.0891 1.46 1.12-1.91 0.00502 TRUE FALSE FALSE FALSE Female 473 4723 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode184-11-phelan-ieoc-p-5e-07-ukb-20200608 prsweb-phecode184-11-phelan-ieoc-p-5e-07-ukb-20200608 PRSWEB_PHECODE184.11_Phelan-IEOC_P_5e-07_UKB_20200608 P_5e-07 PRSWEB_PHECODE184.11_Phelan-IEOC_P_5e-07_UKB_20200608 184.11 Invasive epithelial ovarian cancer Binary Invasive epithelial ovarian cancer UKB UK Biobank Fixed threshold (5e-07) Phelan CM et al. 2017 28346442 https://www.ncbi.nlm.nih.gov/pubmed/?term=28346442 23 7e-07 0.00383211 0.0823 0.567 0.539-0.595 OR 1.97 0.971-4 1.97 0.971-4 1.53 0.872-2.69 1.53 0.872-2.69 1.62 1.13-2.32 1.62 1.13-2.32 1.78 1.37-2.31 1.78 1.37-2.31 1.46 1.2-1.79 1.46 1.2-1.79 1.29 0.963-1.74 0.0875 1.51 1.14-2.02 0.00456 1.88 1.42-2.48 8.34e-06 TRUE FALSE FALSE FALSE Female 473 4723 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode184-11-phelan-lsasboc-p-5e-07-ukb-20200608 prsweb-phecode184-11-phelan-lsasboc-p-5e-07-ukb-20200608 PRSWEB_PHECODE184.11_Phelan-LSASBOC_P_5e-07_UKB_20200608 P_5e-07 PRSWEB_PHECODE184.11_Phelan-LSASBOC_P_5e-07_UKB_20200608 184.11 Low-grade serous and serous borderline ovarian cancer Binary Low-grade serous and serous borderline ovarian cancer UKB UK Biobank Fixed threshold (5e-07) Phelan CM et al. 2017 28346442 https://www.ncbi.nlm.nih.gov/pubmed/?term=28346442 13 0.0056 0.00546495 0.0826 0.542 0.516-0.569 OR 2.82 1.53-5.22 2.82 1.53-5.22 2.08 1.26-3.42 2.08 1.26-3.42 1.57 1.1-2.26 1.57 1.1-2.26 1.29 0.966-1.72 1.29 0.966-1.72 1.15 0.932-1.42 1.15 0.932-1.42 1.17 0.885-1.56 0.268 1.37 1.04-1.8 0.0236 1.37 1.04-1.8 0.0241 TRUE FALSE FALSE FALSE Female 473 4723 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode184-11-phelan-sioc-p-5e-07-ukb-20200608 prsweb-phecode184-11-phelan-sioc-p-5e-07-ukb-20200608 PRSWEB_PHECODE184.11_Phelan-SIOC_P_5e-07_UKB_20200608 P_5e-07 PRSWEB_PHECODE184.11_Phelan-SIOC_P_5e-07_UKB_20200608 184.11 Serous invasive ovarian cancer Binary Serous invasive ovarian cancer UKB UK Biobank Fixed threshold (5e-07) Phelan CM et al. 2017 28346442 https://www.ncbi.nlm.nih.gov/pubmed/?term=28346442 31 4.5e-05 0.00399038 0.0825 0.547 0.518-0.575 OR 1.76 0.838-3.69 1.76 0.838-3.69 1.64 0.947-2.83 1.64 0.947-2.83 1.39 0.952-2.03 1.39 0.952-2.03 1.49 1.13-1.96 1.49 1.13-1.96 1.41 1.15-1.73 1.41 1.15-1.73 1.13 0.85-1.51 0.396 1.28 0.966-1.69 0.0862 1.61 1.23-2.1 0.000551 TRUE FALSE FALSE FALSE Female 473 4723 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode184-11-gwas-catalog-r2019-05-03-x184-11-p-5e-09-ukb-20200608 prsweb-phecode184-11-gwas-catalog-r2019-05-03-x184-11-p-5e-09-ukb-20200608 PRSWEB_PHECODE184.11_GWAS-Catalog-r2019-05-03-X184.11_P_5e-09_UKB_20200608 P_5e-09 PRSWEB_PHECODE184.11_GWAS-Catalog-r2019-05-03-X184.11_P_5e-09_UKB_20200608 184.11 Epithelial ovarian cancer;High-grade serous ovarian cancer;Serous invasive ovarian cancer;Invasive epithelial ovarian cancer;Mucinous ovarian carcinoma;Low-grade serous and serous borderline ovarian cancer;Serous borderline ovarian cancer;Ovarian cancer in BRCA1 mutation carriers;Ovarian cancer;Ovarian clear cell cancer Binary 32 unique SNPs UKB UK Biobank Fixed threshold (5e-09) GWAS Catalog (2019-05-03) 19648919;21964575;23544013;25581431;28346442 https://www.ncbi.nlm.nih.gov/pubmed/?term=19648919+21964575+23544013+25581431+28346442 14 0.0042 0.000390947 0.0826 0.535 0.508-0.562 OR 1.13 0.463-2.77 1.13 0.463-2.77 0.99 0.504-1.95 0.99 0.504-1.95 1.25 0.844-1.86 1.25 0.844-1.86 1.26 0.946-1.69 1.26 0.946-1.69 1.21 0.984-1.49 1.21 0.984-1.49 1.18 0.885-1.57 0.26 1.47 1.11-1.93 0.0063 1.47 1.12-1.94 0.0059 TRUE FALSE FALSE FALSE Female 473 4723 GRCh37/hg19 P<=5e-09 2020-06-08 prsweb-phecode184-11-phelan-epoc-p-5e-09-ukb-20200608 prsweb-phecode184-11-phelan-epoc-p-5e-09-ukb-20200608 PRSWEB_PHECODE184.11_Phelan-EPOC_P_5e-09_UKB_20200608 P_5e-09 PRSWEB_PHECODE184.11_Phelan-EPOC_P_5e-09_UKB_20200608 184.11 Epithelial ovarian cancer Binary Epithelial ovarian cancer UKB UK Biobank Fixed threshold (5e-09) Phelan CM et al. 2017 28346442 https://www.ncbi.nlm.nih.gov/pubmed/?term=28346442 5 0.0012 0.00222167 0.0826 0.544 0.516-0.572 OR 1.18 0.547-2.54 1.18 0.547-2.54 0.884 0.435-1.8 0.884 0.435-1.8 1.24 0.837-1.84 1.24 0.837-1.84 1.35 1.04-1.76 1.35 1.04-1.76 1.34 1.09-1.65 1.34 1.09-1.65 1.14 0.86-1.5 0.368 1.28 0.976-1.68 0.0741 1.52 1.18-1.96 0.00139 TRUE FALSE FALSE FALSE Female 473 4723 GRCh37/hg19 P<=5e-09 2020-06-08 prsweb-phecode184-11-phelan-ieoc-p-5e-09-ukb-20200608 prsweb-phecode184-11-phelan-ieoc-p-5e-09-ukb-20200608 PRSWEB_PHECODE184.11_Phelan-IEOC_P_5e-09_UKB_20200608 P_5e-09 PRSWEB_PHECODE184.11_Phelan-IEOC_P_5e-09_UKB_20200608 184.11 Invasive epithelial ovarian cancer Binary Invasive epithelial ovarian cancer UKB UK Biobank Fixed threshold (5e-09) Phelan CM et al. 2017 28346442 https://www.ncbi.nlm.nih.gov/pubmed/?term=28346442 13 2e-06 0.00600953 0.0824 0.561 0.533-0.589 OR 1.34 0.585-3.08 1.34 0.585-3.08 1.42 0.796-2.54 1.42 0.796-2.54 1.53 1.06-2.21 1.53 1.06-2.21 1.57 1.2-2.06 1.57 1.2-2.06 1.51 1.23-1.84 1.51 1.23-1.84 1.09 0.813-1.47 0.554 1.42 1.07-1.89 0.0139 1.78 1.36-2.34 2.93e-05 TRUE FALSE FALSE FALSE Female 473 4723 GRCh37/hg19 P<=5e-09 2020-06-08 prsweb-phecode184-11-phelan-sioc-p-5e-09-ukb-20200608 prsweb-phecode184-11-phelan-sioc-p-5e-09-ukb-20200608 PRSWEB_PHECODE184.11_Phelan-SIOC_P_5e-09_UKB_20200608 P_5e-09 PRSWEB_PHECODE184.11_Phelan-SIOC_P_5e-09_UKB_20200608 184.11 Serous invasive ovarian cancer Binary Serous invasive ovarian cancer UKB UK Biobank Fixed threshold (5e-09) Phelan CM et al. 2017 28346442 https://www.ncbi.nlm.nih.gov/pubmed/?term=28346442 19 1.5e-05 0.00442788 0.0824 0.549 0.52-0.579 OR 1.55 0.709-3.38 1.55 0.709-3.38 1.97 1.18-3.27 1.97 1.18-3.27 1.48 1.02-2.15 1.48 1.02-2.15 1.68 1.29-2.18 1.68 1.29-2.18 1.48 1.21-1.81 1.48 1.21-1.81 1.14 0.854-1.51 0.382 1.2 0.905-1.59 0.205 1.64 1.26-2.15 0.000257 TRUE FALSE FALSE FALSE Female 473 4723 GRCh37/hg19 P<=5e-09 2020-06-08 prsweb-phecode184-11-gwas-catalog-r2019-05-03-x184-11-p-5e-08-ukb-20200608 prsweb-phecode184-11-gwas-catalog-r2019-05-03-x184-11-p-5e-08-ukb-20200608 PRSWEB_PHECODE184.11_GWAS-Catalog-r2019-05-03-X184.11_P_5e-08_UKB_20200608 P_5e-08 PRSWEB_PHECODE184.11_GWAS-Catalog-r2019-05-03-X184.11_P_5e-08_UKB_20200608 184.11 Epithelial ovarian cancer;High-grade serous ovarian cancer;Serous invasive ovarian cancer;Invasive epithelial ovarian cancer;Mucinous ovarian carcinoma;Low-grade serous and serous borderline ovarian cancer;Serous borderline ovarian cancer;Ovarian cancer in BRCA1 mutation carriers;Ovarian cancer;Ovarian clear cell cancer Binary 32 unique SNPs UKB UK Biobank GWAS Hits GWAS Catalog (2019-05-03) 19648919;21964575;23544013;25581431;28346442 https://www.ncbi.nlm.nih.gov/pubmed/?term=19648919+21964575+23544013+25581431+28346442 21 0.017 0.00101702 0.0827 0.532 0.506-0.559 OR 0.923 0.347-2.45 0.923 0.347-2.45 0.99 0.504-1.95 0.99 0.504-1.95 1.07 0.706-1.63 1.07 0.706-1.63 1.12 0.827-1.51 1.12 0.827-1.51 1.15 0.932-1.42 1.15 0.932-1.42 1.04 0.784-1.39 0.776 1.38 1.05-1.8 0.019 1.29 0.987-1.7 0.0624 TRUE FALSE FALSE TRUE Female 473 4723 GRCh37/hg19 P<=5e-08 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000544/ScoringFiles/ phewas/PRSWEB_PHECODE184.11_GWAS-Catalog-r2019-05-03-X184.11_P_5e-08_UKB_20200608/all.tsv phewas/PRSWEB_PHECODE184.11_GWAS-Catalog-r2019-05-03-X184.11_P_5e-08_UKB_20200608/exclusion.tsv 2020-06-08 prsweb-phecode184-11-phelan-epoc-p-5e-08-ukb-20200608 prsweb-phecode184-11-phelan-epoc-p-5e-08-ukb-20200608 PRSWEB_PHECODE184.11_Phelan-EPOC_P_5e-08_UKB_20200608 P_5e-08 PRSWEB_PHECODE184.11_Phelan-EPOC_P_5e-08_UKB_20200608 184.11 Epithelial ovarian cancer Binary Epithelial ovarian cancer UKB UK Biobank GWAS Hits Phelan CM et al. 2017 28346442 https://www.ncbi.nlm.nih.gov/pubmed/?term=28346442 6 0.0027 0.00348298 0.0826 0.544 0.517-0.573 OR 0.922 0.347-2.45 0.922 0.347-2.45 1.41 0.868-2.29 1.41 0.868-2.29 1.34 0.915-1.97 1.34 0.915-1.97 1.26 0.942-1.68 1.26 0.942-1.68 1.26 1.03-1.55 1.26 1.03-1.55 1.07 0.803-1.42 0.653 1.3 0.993-1.71 0.0564 1.54 1.17-2.03 0.00185 TRUE FALSE FALSE TRUE Female 473 4723 GRCh37/hg19 P<=5e-08 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000547/ScoringFiles/ phewas/PRSWEB_PHECODE184.11_Phelan-EPOC_P_5e-08_UKB_20200608/all.tsv phewas/PRSWEB_PHECODE184.11_Phelan-EPOC_P_5e-08_UKB_20200608/exclusion.tsv 2020-06-08 prsweb-phecode184-11-phelan-ieoc-p-5e-08-ukb-20200608 prsweb-phecode184-11-phelan-ieoc-p-5e-08-ukb-20200608 PRSWEB_PHECODE184.11_Phelan-IEOC_P_5e-08_UKB_20200608 P_5e-08 PRSWEB_PHECODE184.11_Phelan-IEOC_P_5e-08_UKB_20200608 184.11 Invasive epithelial ovarian cancer Binary Invasive epithelial ovarian cancer UKB UK Biobank GWAS Hits Phelan CM et al. 2017 28346442 https://www.ncbi.nlm.nih.gov/pubmed/?term=28346442 16 1.1e-06 0.00558958 0.0824 0.567 0.539-0.595 OR 1.76 0.839-3.69 1.76 0.839-3.69 1.86 1.1-3.13 1.86 1.1-3.13 1.58 1.1-2.26 1.58 1.1-2.26 1.65 1.26-2.15 1.65 1.26-2.15 1.49 1.22-1.82 1.49 1.22-1.82 1.24 0.921-1.67 0.158 1.51 1.13-2.01 0.00473 1.86 1.41-2.46 9.74e-06 TRUE FALSE FALSE TRUE Female 473 4723 GRCh37/hg19 P<=5e-08 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000549/ScoringFiles/ phewas/PRSWEB_PHECODE184.11_Phelan-IEOC_P_5e-08_UKB_20200608/all.tsv phewas/PRSWEB_PHECODE184.11_Phelan-IEOC_P_5e-08_UKB_20200608/exclusion.tsv 2020-06-08 prsweb-phecode184-11-phelan-lsasboc-p-5e-08-ukb-20200608 prsweb-phecode184-11-phelan-lsasboc-p-5e-08-ukb-20200608 PRSWEB_PHECODE184.11_Phelan-LSASBOC_P_5e-08_UKB_20200608 P_5e-08 PRSWEB_PHECODE184.11_Phelan-LSASBOC_P_5e-08_UKB_20200608 184.11 Low-grade serous and serous borderline ovarian cancer Binary Low-grade serous and serous borderline ovarian cancer UKB UK Biobank GWAS Hits Phelan CM et al. 2017 28346442 https://www.ncbi.nlm.nih.gov/pubmed/?term=28346442 10 0.00044 0.0036141 0.0825 0.556 0.53-0.584 OR 1.76 0.839-3.69 1.76 0.839-3.69 1.86 1.1-3.13 1.86 1.1-3.13 1.44 0.987-2.09 1.44 0.987-2.09 1.52 1.15-1.99 1.52 1.15-1.99 1.48 1.21-1.81 1.48 1.21-1.81 1.27 0.957-1.69 0.0968 1.24 0.934-1.66 0.136 1.71 1.31-2.25 9.9e-05 TRUE FALSE FALSE TRUE Female 473 4723 GRCh37/hg19 P<=5e-08 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000553/ScoringFiles/ phewas/PRSWEB_PHECODE184.11_Phelan-LSASBOC_P_5e-08_UKB_20200608/all.tsv phewas/PRSWEB_PHECODE184.11_Phelan-LSASBOC_P_5e-08_UKB_20200608/exclusion.tsv 2020-06-08 prsweb-phecode184-11-phelan-sioc-p-5e-08-ukb-20200608 prsweb-phecode184-11-phelan-sioc-p-5e-08-ukb-20200608 PRSWEB_PHECODE184.11_Phelan-SIOC_P_5e-08_UKB_20200608 P_5e-08 PRSWEB_PHECODE184.11_Phelan-SIOC_P_5e-08_UKB_20200608 184.11 Serous invasive ovarian cancer Binary Serous invasive ovarian cancer UKB UK Biobank GWAS Hits Phelan CM et al. 2017 28346442 https://www.ncbi.nlm.nih.gov/pubmed/?term=28346442 21 8.4e-06 0.00501366 0.0824 0.552 0.523-0.581 OR 1.76 0.839-3.69 1.76 0.839-3.69 1.75 1.03-2.98 1.75 1.03-2.98 1.86 1.32-2.62 1.86 1.32-2.62 1.73 1.33-2.25 1.73 1.33-2.25 1.46 1.2-1.79 1.46 1.2-1.79 1.02 0.765-1.37 0.882 1.24 0.939-1.64 0.13 1.59 1.22-2.08 0.000581 TRUE FALSE FALSE TRUE Female 473 4723 GRCh37/hg19 P<=5e-08 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000560/ScoringFiles/ phewas/PRSWEB_PHECODE184.11_Phelan-SIOC_P_5e-08_UKB_20200608/all.tsv phewas/PRSWEB_PHECODE184.11_Phelan-SIOC_P_5e-08_UKB_20200608/exclusion.tsv 2020-06-08 prsweb-phecode184-11-gwas-catalog-r2019-05-03-x184-11-pt-ukb-20200608 prsweb-phecode184-11-gwas-catalog-r2019-05-03-x184-11-pt-ukb-20200608 PRSWEB_PHECODE184.11_GWAS-Catalog-r2019-05-03-X184.11_PT_UKB_20200608 P&T PRSWEB_PHECODE184.11_GWAS-Catalog-r2019-05-03-X184.11_PT_UKB_20200608 184.11 Epithelial ovarian cancer;High-grade serous ovarian cancer;Serous invasive ovarian cancer;Invasive epithelial ovarian cancer;Mucinous ovarian carcinoma;Low-grade serous and serous borderline ovarian cancer;Serous borderline ovarian cancer;Ovarian cancer in BRCA1 mutation carriers;Ovarian cancer;Ovarian clear cell cancer Binary 32 unique SNPs UKB UK Biobank P&T GWAS Catalog (2019-05-03) 19648919;21964575;23544013;25581431;28346442 https://www.ncbi.nlm.nih.gov/pubmed/?term=19648919+21964575+23544013+25581431+28346442 21 0.017 0.00101702 0.0827 0.532 0.506-0.559 OR 0.923 0.347-2.45 0.923 0.347-2.45 0.99 0.504-1.95 0.99 0.504-1.95 1.07 0.706-1.63 1.07 0.706-1.63 1.12 0.827-1.51 1.12 0.827-1.51 1.15 0.932-1.42 1.15 0.932-1.42 1.04 0.784-1.39 0.776 1.38 1.05-1.8 0.019 1.29 0.987-1.7 0.0624 TRUE FALSE FALSE TRUE Female 473 4723 GRCh37/hg19 P<=5e-08 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000545/ScoringFiles/ phewas/PRSWEB_PHECODE184.11_GWAS-Catalog-r2019-05-03-X184.11_PT_UKB_20200608/all.tsv phewas/PRSWEB_PHECODE184.11_GWAS-Catalog-r2019-05-03-X184.11_PT_UKB_20200608/exclusion.tsv 2020-06-08 prsweb-phecode184-11-phelan-epoc-pt-ukb-20200608 prsweb-phecode184-11-phelan-epoc-pt-ukb-20200608 PRSWEB_PHECODE184.11_Phelan-EPOC_PT_UKB_20200608 P&T PRSWEB_PHECODE184.11_Phelan-EPOC_PT_UKB_20200608 184.11 Epithelial ovarian cancer Binary Epithelial ovarian cancer UKB UK Biobank P&T Phelan CM et al. 2017 28346442 https://www.ncbi.nlm.nih.gov/pubmed/?term=28346442 40 0.1 0.00482326 0.0827 0.526 0.5-0.554 OR 1.34 0.584-3.07 1.34 0.584-3.07 1.2 0.647-2.24 1.2 0.647-2.24 1.21 0.809-1.8 1.21 0.809-1.8 1.14 0.846-1.54 1.14 0.846-1.54 1.37 1.11-1.68 1.37 1.11-1.68 0.897 0.678-1.19 0.447 1.01 0.771-1.33 0.934 1.33 1.03-1.72 0.0315 FALSE FALSE FALSE FALSE Female 473 4723 GRCh37/hg19 P<=1e-05 2020-06-08 prsweb-phecode184-11-phelan-hsoc-pt-ukb-20200608 prsweb-phecode184-11-phelan-hsoc-pt-ukb-20200608 PRSWEB_PHECODE184.11_Phelan-HSOC_PT_UKB_20200608 P&T PRSWEB_PHECODE184.11_Phelan-HSOC_PT_UKB_20200608 184.11 High-grade serous ovarian cancer Binary High-grade serous ovarian cancer UKB UK Biobank P&T Phelan CM et al. 2017 28346442 https://www.ncbi.nlm.nih.gov/pubmed/?term=28346442 88 0.086 0.00192282 0.0827 0.523 0.494-0.551 OR 0.924 0.348-2.46 0.924 0.348-2.46 0.99 0.504-1.95 0.99 0.504-1.95 1.16 0.774-1.75 1.16 0.774-1.75 1.12 0.827-1.51 1.12 0.827-1.51 1.12 0.902-1.38 1.12 0.902-1.38 1.06 0.801-1.39 0.699 1.2 0.916-1.57 0.187 1.22 0.931-1.59 0.151 FALSE FALSE FALSE FALSE Female 473 4723 GRCh37/hg19 P<=3.98e-05 2020-06-08 prsweb-phecode184-11-phelan-ieoc-pt-ukb-20200608 prsweb-phecode184-11-phelan-ieoc-pt-ukb-20200608 PRSWEB_PHECODE184.11_Phelan-IEOC_PT_UKB_20200608 P&T PRSWEB_PHECODE184.11_Phelan-IEOC_PT_UKB_20200608 184.11 Invasive epithelial ovarian cancer Binary Invasive epithelial ovarian cancer UKB UK Biobank P&T Phelan CM et al. 2017 28346442 https://www.ncbi.nlm.nih.gov/pubmed/?term=28346442 12 8.6e-06 0.00654083 0.0824 0.558 0.53-0.586 OR 1.55 0.71-3.38 1.55 0.71-3.38 1.2 0.648-2.24 1.2 0.648-2.24 1.48 1.02-2.15 1.48 1.02-2.15 1.47 1.11-1.93 1.47 1.11-1.93 1.41 1.15-1.73 1.41 1.15-1.73 1.61 1.2-2.18 0.00172 1.72 1.28-2.31 0.000333 2.05 1.54-2.73 1.06e-06 TRUE FALSE FALSE TRUE Female 473 4723 GRCh37/hg19 P<=1.26e-09 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000551/ScoringFiles/ phewas/PRSWEB_PHECODE184.11_Phelan-IEOC_PT_UKB_20200608/all.tsv phewas/PRSWEB_PHECODE184.11_Phelan-IEOC_PT_UKB_20200608/exclusion.tsv 2020-06-08 prsweb-phecode184-11-phelan-lsasboc-pt-ukb-20200608 prsweb-phecode184-11-phelan-lsasboc-pt-ukb-20200608 PRSWEB_PHECODE184.11_Phelan-LSASBOC_PT_UKB_20200608 P&T PRSWEB_PHECODE184.11_Phelan-LSASBOC_PT_UKB_20200608 184.11 Low-grade serous and serous borderline ovarian cancer Binary Low-grade serous and serous borderline ovarian cancer UKB UK Biobank P&T Phelan CM et al. 2017 28346442 https://www.ncbi.nlm.nih.gov/pubmed/?term=28346442 15 0.0099 0.00655237 0.0826 0.539 0.513-0.568 OR 2.18 1.11-4.3 2.18 1.11-4.3 2.08 1.26-3.42 2.08 1.26-3.42 1.77 1.25-2.5 1.77 1.25-2.5 1.39 1.05-1.84 1.39 1.05-1.84 1.21 0.984-1.49 1.21 0.984-1.49 1.13 0.849-1.49 0.408 1.31 0.993-1.72 0.0563 1.39 1.06-1.82 0.0172 TRUE FALSE FALSE TRUE Female 473 4723 GRCh37/hg19 P<=1.58e-06 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000555/ScoringFiles/ phewas/PRSWEB_PHECODE184.11_Phelan-LSASBOC_PT_UKB_20200608/all.tsv phewas/PRSWEB_PHECODE184.11_Phelan-LSASBOC_PT_UKB_20200608/exclusion.tsv 2020-06-08 prsweb-phecode184-11-phelan-lsoc-pt-ukb-20200608 prsweb-phecode184-11-phelan-lsoc-pt-ukb-20200608 PRSWEB_PHECODE184.11_Phelan-LSOC_PT_UKB_20200608 P&T PRSWEB_PHECODE184.11_Phelan-LSOC_PT_UKB_20200608 184.11 Low-grade serous ovarian cancer Binary Low-grade serous ovarian cancer UKB UK Biobank P&T Phelan CM et al. 2017 28346442 https://www.ncbi.nlm.nih.gov/pubmed/?term=28346442 29 0.75 0.000711259 0.0827 0.503 0.475-0.531 OR 0.924 0.348-2.46 0.924 0.348-2.46 0.569 0.239-1.35 0.569 0.239-1.35 0.985 0.638-1.52 0.985 0.638-1.52 1 0.73-1.37 1 0.73-1.37 1.21 0.984-1.49 1.21 0.984-1.49 0.824 0.63-1.08 0.157 0.8 0.61-1.05 0.107 1.06 0.826-1.37 0.627 FALSE FALSE FALSE FALSE Female 473 4723 GRCh37/hg19 P<=1e-05 2020-06-08 prsweb-phecode184-11-phelan-mcoc-pt-ukb-20200608 prsweb-phecode184-11-phelan-mcoc-pt-ukb-20200608 PRSWEB_PHECODE184.11_Phelan-MCOC_PT_UKB_20200608 P&T PRSWEB_PHECODE184.11_Phelan-MCOC_PT_UKB_20200608 184.11 Mucinous ovarian carcinoma Binary Mucinous ovarian carcinoma UKB UK Biobank P&T Phelan CM et al. 2017 28346442 https://www.ncbi.nlm.nih.gov/pubmed/?term=28346442 45 0.51 0.00531703 0.0827 0.51 0.481-0.538 OR 0.924 0.348-2.46 0.924 0.348-2.46 0.778 0.367-1.65 0.778 0.367-1.65 0.941 0.604-1.47 0.941 0.604-1.47 1.02 0.749-1.4 1.02 0.749-1.4 1.09 0.881-1.35 1.09 0.881-1.35 1.1 0.838-1.43 0.502 1.03 0.781-1.35 0.857 1.12 0.861-1.47 0.389 FALSE FALSE FALSE FALSE Female 473 4723 GRCh37/hg19 P<=1e-05 2020-06-08 prsweb-phecode184-11-phelan-occc-pt-ukb-20200608 prsweb-phecode184-11-phelan-occc-pt-ukb-20200608 PRSWEB_PHECODE184.11_Phelan-OCCC_PT_UKB_20200608 P&T PRSWEB_PHECODE184.11_Phelan-OCCC_PT_UKB_20200608 184.11 Ovarian clear cell cancer Binary Ovarian clear cell cancer UKB UK Biobank P&T Phelan CM et al. 2017 28346442 https://www.ncbi.nlm.nih.gov/pubmed/?term=28346442 84 0.45 0.00276851 0.0827 0.51 0.482-0.538 OR 1.76 0.839-3.7 1.76 0.839-3.7 1.31 0.721-2.39 1.31 0.721-2.39 1.48 1.02-2.15 1.48 1.02-2.15 1.26 0.946-1.69 1.26 0.946-1.69 1.1 0.891-1.37 1.1 0.891-1.37 1.15 0.88-1.51 0.304 1.07 0.816-1.41 0.612 1.19 0.912-1.56 0.199 FALSE FALSE FALSE FALSE Female 473 4723 GRCh37/hg19 P<=3.98e-05 2020-06-08 prsweb-phecode184-11-phelan-sioc-pt-ukb-20200608 prsweb-phecode184-11-phelan-sioc-pt-ukb-20200608 PRSWEB_PHECODE184.11_Phelan-SIOC_PT_UKB_20200608 P&T PRSWEB_PHECODE184.11_Phelan-SIOC_PT_UKB_20200608 184.11 Serous invasive ovarian cancer Binary Serous invasive ovarian cancer UKB UK Biobank P&T Phelan CM et al. 2017 28346442 https://www.ncbi.nlm.nih.gov/pubmed/?term=28346442 12 0.00023 0.00626094 0.0826 0.547 0.52-0.574 OR 0.511 0.142-1.84 0.511 0.142-1.84 1.31 0.721-2.39 1.31 0.721-2.39 1.25 0.845-1.86 1.25 0.845-1.86 1.29 0.966-1.72 1.29 0.966-1.72 1.37 1.11-1.68 1.37 1.11-1.68 1.55 1.15-2.07 0.00355 1.56 1.16-2.08 0.00303 1.86 1.4-2.47 1.69e-05 TRUE FALSE FALSE TRUE Female 473 4723 GRCh37/hg19 P<=6.31e-11 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000563/ScoringFiles/ phewas/PRSWEB_PHECODE184.11_Phelan-SIOC_PT_UKB_20200608/all.tsv phewas/PRSWEB_PHECODE184.11_Phelan-SIOC_PT_UKB_20200608/exclusion.tsv 2020-06-08 prsweb-phecode184-11-phelan-enoc-prs-cs-ukb-20200608 prsweb-phecode184-11-phelan-enoc-prs-cs-ukb-20200608 PRSWEB_PHECODE184.11_Phelan-ENOC_PRS-CS_UKB_20200608 PRS-CS PRSWEB_PHECODE184.11_Phelan-ENOC_PRS-CS_UKB_20200608 184.11 Endometrioid ovarian cancer Binary Endometrioid ovarian cancer UKB UK Biobank PRS-CS Phelan CM et al. 2017 28346442 https://www.ncbi.nlm.nih.gov/pubmed/?term=28346442 1115189 0.022 0.000440588 0.0827 0.526 0.498-0.554 OR 1.97 0.973-4 1.97 0.973-4 1.31 0.721-2.39 1.31 0.721-2.39 1.3 0.88-1.92 1.3 0.88-1.92 1.21 0.906-1.63 1.21 0.906-1.63 1.3 1.06-1.6 1.3 1.06-1.6 0.938 0.714-1.23 0.649 0.932 0.709-1.23 0.616 1.24 0.961-1.61 0.0974 TRUE FALSE FALSE TRUE Female 473 4723 GRCh37/hg19 auto https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000546/ScoringFiles/ phewas/PRSWEB_PHECODE184.11_Phelan-ENOC_PRS-CS_UKB_20200608/all.tsv phewas/PRSWEB_PHECODE184.11_Phelan-ENOC_PRS-CS_UKB_20200608/exclusion.tsv 2020-06-08 prsweb-phecode184-11-phelan-epoc-prs-cs-ukb-20200608 prsweb-phecode184-11-phelan-epoc-prs-cs-ukb-20200608 PRSWEB_PHECODE184.11_Phelan-EPOC_PRS-CS_UKB_20200608 PRS-CS PRSWEB_PHECODE184.11_Phelan-EPOC_PRS-CS_UKB_20200608 184.11 Epithelial ovarian cancer Binary Epithelial ovarian cancer UKB UK Biobank PRS-CS Phelan CM et al. 2017 28346442 https://www.ncbi.nlm.nih.gov/pubmed/?term=28346442 1115189 0.14 0.000555401 0.0827 0.516 0.488-0.546 OR 2.4 1.25-4.62 2.4 1.25-4.62 2.3 1.43-3.72 2.3 1.43-3.72 1.62 1.13-2.32 1.62 1.13-2.32 1.24 0.926-1.66 1.24 0.926-1.66 1.18 0.952-1.45 1.18 0.952-1.45 0.956 0.73-1.25 0.743 0.951 0.726-1.25 0.718 1.12 0.864-1.45 0.39 FALSE FALSE FALSE FALSE Female 473 4723 GRCh37/hg19 auto 2020-06-08 prsweb-phecode184-11-phelan-hsoc-prs-cs-ukb-20200608 prsweb-phecode184-11-phelan-hsoc-prs-cs-ukb-20200608 PRSWEB_PHECODE184.11_Phelan-HSOC_PRS-CS_UKB_20200608 PRS-CS PRSWEB_PHECODE184.11_Phelan-HSOC_PRS-CS_UKB_20200608 184.11 High-grade serous ovarian cancer Binary High-grade serous ovarian cancer UKB UK Biobank PRS-CS Phelan CM et al. 2017 28346442 https://www.ncbi.nlm.nih.gov/pubmed/?term=28346442 1115189 0.92 0.000338134 0.0827 0.503 0.475-0.532 OR 1.13 0.464-2.77 1.13 0.464-2.77 1.21 0.648-2.25 1.21 0.648-2.25 1.03 0.672-1.58 1.03 0.672-1.58 1.05 0.769-1.43 1.05 0.769-1.43 1.06 0.852-1.31 1.06 0.852-1.31 0.846 0.644-1.11 0.226 0.995 0.766-1.29 0.972 1.01 0.774-1.31 0.967 FALSE FALSE FALSE FALSE Female 473 4723 GRCh37/hg19 auto 2020-06-08 prsweb-phecode184-11-phelan-ieoc-prs-cs-ukb-20200608 prsweb-phecode184-11-phelan-ieoc-prs-cs-ukb-20200608 PRSWEB_PHECODE184.11_Phelan-IEOC_PRS-CS_UKB_20200608 PRS-CS PRSWEB_PHECODE184.11_Phelan-IEOC_PRS-CS_UKB_20200608 184.11 Invasive epithelial ovarian cancer Binary Invasive epithelial ovarian cancer UKB UK Biobank PRS-CS Phelan CM et al. 2017 28346442 https://www.ncbi.nlm.nih.gov/pubmed/?term=28346442 1115189 2.3e-07 0.0119391 0.0823 0.568 0.542-0.595 OR 1.76 0.838-3.7 1.76 0.838-3.7 2.19 1.34-3.57 2.19 1.34-3.57 2.05 1.48-2.85 2.05 1.48-2.85 1.81 1.4-2.34 1.81 1.4-2.34 1.35 1.1-1.66 1.35 1.1-1.66 1.41 1.05-1.91 0.023 1.77 1.33-2.36 9.76e-05 1.88 1.42-2.5 1.35e-05 TRUE FALSE FALSE TRUE Female 473 4723 GRCh37/hg19 auto https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000550/ScoringFiles/ phewas/PRSWEB_PHECODE184.11_Phelan-IEOC_PRS-CS_UKB_20200608/all.tsv phewas/PRSWEB_PHECODE184.11_Phelan-IEOC_PRS-CS_UKB_20200608/exclusion.tsv 2020-06-08 prsweb-phecode184-11-phelan-lsasboc-prs-cs-ukb-20200608 prsweb-phecode184-11-phelan-lsasboc-prs-cs-ukb-20200608 PRSWEB_PHECODE184.11_Phelan-LSASBOC_PRS-CS_UKB_20200608 PRS-CS PRSWEB_PHECODE184.11_Phelan-LSASBOC_PRS-CS_UKB_20200608 184.11 Low-grade serous and serous borderline ovarian cancer Binary Low-grade serous and serous borderline ovarian cancer UKB UK Biobank PRS-CS Phelan CM et al. 2017 28346442 https://www.ncbi.nlm.nih.gov/pubmed/?term=28346442 1115189 0.032 0.00139645 0.0827 0.522 0.491-0.548 OR 3.92 2.27-6.79 3.92 2.27-6.79 2.65 1.68-4.18 2.65 1.68-4.18 1.44 0.988-2.09 1.44 0.988-2.09 1.21 0.906-1.63 1.21 0.906-1.63 1.14 0.922-1.41 1.14 0.922-1.41 0.987 0.751-1.3 0.925 1.05 0.803-1.37 0.718 1.15 0.88-1.49 0.312 TRUE FALSE FALSE TRUE Female 473 4723 GRCh37/hg19 auto https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000554/ScoringFiles/ phewas/PRSWEB_PHECODE184.11_Phelan-LSASBOC_PRS-CS_UKB_20200608/all.tsv phewas/PRSWEB_PHECODE184.11_Phelan-LSASBOC_PRS-CS_UKB_20200608/exclusion.tsv 2020-06-08 prsweb-phecode184-11-phelan-lsoc-prs-cs-ukb-20200608 prsweb-phecode184-11-phelan-lsoc-prs-cs-ukb-20200608 PRSWEB_PHECODE184.11_Phelan-LSOC_PRS-CS_UKB_20200608 PRS-CS PRSWEB_PHECODE184.11_Phelan-LSOC_PRS-CS_UKB_20200608 184.11 Low-grade serous ovarian cancer Binary Low-grade serous ovarian cancer UKB UK Biobank PRS-CS Phelan CM et al. 2017 28346442 https://www.ncbi.nlm.nih.gov/pubmed/?term=28346442 1115179 0.26 0.00169979 0.0827 0.504 0.477-0.533 OR 1.97 0.971-4 1.97 0.971-4 1.1 0.575-2.1 1.1 0.575-2.1 1.21 0.809-1.8 1.21 0.809-1.8 1.09 0.807-1.48 1.09 0.807-1.48 0.966 0.775-1.2 0.966 0.775-1.2 1.03 0.788-1.34 0.833 1.07 0.821-1.39 0.618 0.989 0.756-1.29 0.937 FALSE FALSE FALSE FALSE Female 473 4723 GRCh37/hg19 auto 2020-06-08 prsweb-phecode184-11-phelan-mcoc-prs-cs-ukb-20200608 prsweb-phecode184-11-phelan-mcoc-prs-cs-ukb-20200608 PRSWEB_PHECODE184.11_Phelan-MCOC_PRS-CS_UKB_20200608 PRS-CS PRSWEB_PHECODE184.11_Phelan-MCOC_PRS-CS_UKB_20200608 184.11 Mucinous ovarian carcinoma Binary Mucinous ovarian carcinoma UKB UK Biobank PRS-CS Phelan CM et al. 2017 28346442 https://www.ncbi.nlm.nih.gov/pubmed/?term=28346442 1115189 0.26 0.000772542 0.0827 0.509 0.483-0.536 OR 2.4 1.25-4.63 2.4 1.25-4.63 1.75 1.03-2.99 1.75 1.03-2.99 1.25 0.845-1.86 1.25 0.845-1.86 1.19 0.886-1.6 1.19 0.886-1.6 1.15 0.932-1.42 1.15 0.932-1.42 0.898 0.687-1.17 0.431 0.867 0.662-1.14 0.3 1.05 0.808-1.35 0.735 FALSE FALSE FALSE FALSE Female 473 4723 GRCh37/hg19 auto 2020-06-08 prsweb-phecode184-11-phelan-occc-prs-cs-ukb-20200608 prsweb-phecode184-11-phelan-occc-prs-cs-ukb-20200608 PRSWEB_PHECODE184.11_Phelan-OCCC_PRS-CS_UKB_20200608 PRS-CS PRSWEB_PHECODE184.11_Phelan-OCCC_PRS-CS_UKB_20200608 184.11 Ovarian clear cell cancer Binary Ovarian clear cell cancer UKB UK Biobank PRS-CS Phelan CM et al. 2017 28346442 https://www.ncbi.nlm.nih.gov/pubmed/?term=28346442 1115187 0.0039 0.00346787 0.0826 0.534 0.508-0.562 OR 1.55 0.71-3.38 1.55 0.71-3.38 1.75 1.03-2.98 1.75 1.03-2.98 1.53 1.06-2.2 1.53 1.06-2.2 1.39 1.05-1.84 1.39 1.05-1.84 1.38 1.13-1.7 1.38 1.13-1.7 0.975 0.736-1.29 0.859 1.08 0.822-1.43 0.571 1.41 1.09-1.83 0.00997 TRUE FALSE FALSE TRUE Female 473 4723 GRCh37/hg19 auto https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000557/ScoringFiles/ phewas/PRSWEB_PHECODE184.11_Phelan-OCCC_PRS-CS_UKB_20200608/all.tsv phewas/PRSWEB_PHECODE184.11_Phelan-OCCC_PRS-CS_UKB_20200608/exclusion.tsv 2020-06-08 prsweb-phecode184-11-phelan-sioc-prs-cs-ukb-20200608 prsweb-phecode184-11-phelan-sioc-prs-cs-ukb-20200608 PRSWEB_PHECODE184.11_Phelan-SIOC_PRS-CS_UKB_20200608 PRS-CS PRSWEB_PHECODE184.11_Phelan-SIOC_PRS-CS_UKB_20200608 184.11 Serous invasive ovarian cancer Binary Serous invasive ovarian cancer UKB UK Biobank PRS-CS Phelan CM et al. 2017 28346442 https://www.ncbi.nlm.nih.gov/pubmed/?term=28346442 1115189 8.9e-05 0.0158094 0.0825 0.552 0.526-0.58 OR 1.55 0.708-3.38 1.55 0.708-3.38 1.64 0.947-2.83 1.64 0.947-2.83 1.72 1.21-2.44 1.72 1.21-2.44 1.75 1.35-2.28 1.75 1.35-2.28 1.54 1.26-1.88 1.54 1.26-1.88 1.04 0.784-1.38 0.779 1.1 0.831-1.46 0.502 1.6 1.23-2.08 0.000444 TRUE FALSE FALSE TRUE Female 473 4723 GRCh37/hg19 auto https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000562/ScoringFiles/ phewas/PRSWEB_PHECODE184.11_Phelan-SIOC_PRS-CS_UKB_20200608/all.tsv phewas/PRSWEB_PHECODE184.11_Phelan-SIOC_PRS-CS_UKB_20200608/exclusion.tsv 2020-06-08 prsweb-phecode184-11-phelan-epoc-lassosum-ukb-20200608 prsweb-phecode184-11-phelan-epoc-lassosum-ukb-20200608 PRSWEB_PHECODE184.11_Phelan-EPOC_LASSOSUM_UKB_20200608 Lassosum PRSWEB_PHECODE184.11_Phelan-EPOC_LASSOSUM_UKB_20200608 184.11 Epithelial ovarian cancer Binary Epithelial ovarian cancer UKB UK Biobank lassosum Phelan CM et al. 2017 28346442 https://www.ncbi.nlm.nih.gov/pubmed/?term=28346442 1441 0.01 0.00393675 0.0826 0.538 0.512-0.565 OR 1.13 0.463-2.77 1.13 0.463-2.77 1.1 0.576-2.1 1.1 0.576-2.1 1.34 0.915-1.97 1.34 0.915-1.97 1.31 0.987-1.75 1.31 0.987-1.75 1.24 1.01-1.52 1.24 1.01-1.52 1.06 0.796-1.4 0.705 1.28 0.977-1.68 0.0729 1.38 1.05-1.8 0.0194 TRUE FALSE FALSE TRUE Female 473 4723 GRCh37/hg19 s=0.5;Lambda=0.01438 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000548/ScoringFiles/ phewas/PRSWEB_PHECODE184.11_Phelan-EPOC_LASSOSUM_UKB_20200608/all.tsv phewas/PRSWEB_PHECODE184.11_Phelan-EPOC_LASSOSUM_UKB_20200608/exclusion.tsv 2020-06-08 prsweb-phecode184-11-phelan-hsoc-lassosum-ukb-20200608 prsweb-phecode184-11-phelan-hsoc-lassosum-ukb-20200608 PRSWEB_PHECODE184.11_Phelan-HSOC_LASSOSUM_UKB_20200608 Lassosum PRSWEB_PHECODE184.11_Phelan-HSOC_LASSOSUM_UKB_20200608 184.11 High-grade serous ovarian cancer Binary High-grade serous ovarian cancer UKB UK Biobank lassosum Phelan CM et al. 2017 28346442 https://www.ncbi.nlm.nih.gov/pubmed/?term=28346442 37433 0.35 0.00184855 0.0827 0.514 0.487-0.54 OR 0.923 0.347-2.45 0.923 0.347-2.45 1.1 0.574-2.09 1.1 0.574-2.09 1.21 0.81-1.8 1.21 0.81-1.8 1.22 0.906-1.63 1.22 0.906-1.63 1.07 0.862-1.32 1.07 0.862-1.32 1.07 0.817-1.41 0.617 1.1 0.838-1.44 0.499 1.13 0.861-1.47 0.388 FALSE FALSE FALSE FALSE Female 473 4723 GRCh37/hg19 s=1;Lambda=0.01438 2020-06-08 prsweb-phecode184-11-phelan-ieoc-lassosum-ukb-20200608 prsweb-phecode184-11-phelan-ieoc-lassosum-ukb-20200608 PRSWEB_PHECODE184.11_Phelan-IEOC_LASSOSUM_UKB_20200608 Lassosum PRSWEB_PHECODE184.11_Phelan-IEOC_LASSOSUM_UKB_20200608 184.11 Invasive epithelial ovarian cancer Binary Invasive epithelial ovarian cancer UKB UK Biobank lassosum Phelan CM et al. 2017 28346442 https://www.ncbi.nlm.nih.gov/pubmed/?term=28346442 41269 0.00028 0.0118842 0.0825 0.552 0.523-0.58 OR 1.97 0.97-3.99 1.97 0.97-3.99 1.75 1.02-2.98 1.75 1.02-2.98 1.48 1.02-2.15 1.48 1.02-2.15 1.44 1.09-1.9 1.44 1.09-1.9 1.4 1.14-1.71 1.4 1.14-1.71 1.09 0.815-1.45 0.573 1.26 0.954-1.66 0.103 1.6 1.22-2.09 0.000634 TRUE FALSE FALSE TRUE Female 473 4723 GRCh37/hg19 s=0.9;Lambda=0.01129 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000552/ScoringFiles/ phewas/PRSWEB_PHECODE184.11_Phelan-IEOC_LASSOSUM_UKB_20200608/all.tsv phewas/PRSWEB_PHECODE184.11_Phelan-IEOC_LASSOSUM_UKB_20200608/exclusion.tsv 2020-06-08 prsweb-phecode184-11-phelan-lsasboc-lassosum-ukb-20200608 prsweb-phecode184-11-phelan-lsasboc-lassosum-ukb-20200608 PRSWEB_PHECODE184.11_Phelan-LSASBOC_LASSOSUM_UKB_20200608 Lassosum PRSWEB_PHECODE184.11_Phelan-LSASBOC_LASSOSUM_UKB_20200608 184.11 Low-grade serous and serous borderline ovarian cancer Binary Low-grade serous and serous borderline ovarian cancer UKB UK Biobank lassosum Phelan CM et al. 2017 28346442 https://www.ncbi.nlm.nih.gov/pubmed/?term=28346442 486841 0.016 0.00512977 0.0826 0.516 0.489-0.544 OR 2.4 1.24-4.62 2.4 1.24-4.62 1.21 0.648-2.24 1.21 0.648-2.24 1.12 0.74-1.69 1.12 0.74-1.69 1.12 0.827-1.51 1.12 0.827-1.51 1.13 0.912-1.39 1.13 0.912-1.39 1.11 0.843-1.45 0.469 1.07 0.818-1.41 0.605 1.19 0.907-1.55 0.212 TRUE FALSE FALSE TRUE Female 473 4723 GRCh37/hg19 s=0.2;Lambda=0.008859 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000556/ScoringFiles/ phewas/PRSWEB_PHECODE184.11_Phelan-LSASBOC_LASSOSUM_UKB_20200608/all.tsv phewas/PRSWEB_PHECODE184.11_Phelan-LSASBOC_LASSOSUM_UKB_20200608/exclusion.tsv 2020-06-08 prsweb-phecode184-11-phelan-lsoc-lassosum-ukb-20200608 prsweb-phecode184-11-phelan-lsoc-lassosum-ukb-20200608 PRSWEB_PHECODE184.11_Phelan-LSOC_LASSOSUM_UKB_20200608 Lassosum PRSWEB_PHECODE184.11_Phelan-LSOC_LASSOSUM_UKB_20200608 184.11 Low-grade serous ovarian cancer Binary Low-grade serous ovarian cancer UKB UK Biobank lassosum Phelan CM et al. 2017 28346442 https://www.ncbi.nlm.nih.gov/pubmed/?term=28346442 1635861 0.03 0.00399895 0.0826 0.498 0.471-0.527 OR 2.83 1.53-5.23 2.83 1.53-5.23 1.86 1.1-3.13 1.86 1.1-3.13 1.07 0.705-1.63 1.07 0.705-1.63 1.05 0.768-1.43 1.05 0.768-1.43 0.955 0.766-1.19 0.955 0.766-1.19 1.19 0.912-1.55 0.201 1.07 0.819-1.41 0.611 1.03 0.781-1.35 0.856 TRUE FALSE FALSE FALSE Female 473 4723 GRCh37/hg19 s=0.2;Lambda=0.005456 phewas/PRSWEB_PHECODE184.11_Phelan-LSOC_LASSOSUM_UKB_20200608/all.tsv phewas/PRSWEB_PHECODE184.11_Phelan-LSOC_LASSOSUM_UKB_20200608/exclusion.tsv 2020-06-08 prsweb-phecode184-11-phelan-mcoc-lassosum-ukb-20200608 prsweb-phecode184-11-phelan-mcoc-lassosum-ukb-20200608 PRSWEB_PHECODE184.11_Phelan-MCOC_LASSOSUM_UKB_20200608 Lassosum PRSWEB_PHECODE184.11_Phelan-MCOC_LASSOSUM_UKB_20200608 184.11 Mucinous ovarian carcinoma Binary Mucinous ovarian carcinoma UKB UK Biobank lassosum Phelan CM et al. 2017 28346442 https://www.ncbi.nlm.nih.gov/pubmed/?term=28346442 1467601 0.43 0.0027751 0.0827 0.507 0.48-0.534 OR 1.13 0.464-2.77 1.13 0.464-2.77 0.779 0.368-1.65 0.779 0.368-1.65 0.985 0.638-1.52 0.985 0.638-1.52 0.953 0.692-1.31 0.953 0.692-1.31 1.13 0.912-1.39 1.13 0.912-1.39 1.06 0.814-1.38 0.667 0.875 0.663-1.15 0.343 1.09 0.836-1.41 0.534 FALSE FALSE FALSE FALSE Female 473 4723 GRCh37/hg19 s=0.5;Lambda=0.006952 2020-06-08 prsweb-phecode184-11-phelan-occc-lassosum-ukb-20200608 prsweb-phecode184-11-phelan-occc-lassosum-ukb-20200608 PRSWEB_PHECODE184.11_Phelan-OCCC_LASSOSUM_UKB_20200608 Lassosum PRSWEB_PHECODE184.11_Phelan-OCCC_LASSOSUM_UKB_20200608 184.11 Ovarian clear cell cancer Binary Ovarian clear cell cancer UKB UK Biobank lassosum Phelan CM et al. 2017 28346442 https://www.ncbi.nlm.nih.gov/pubmed/?term=28346442 1098236 5e-05 0.00981931 0.0824 0.546 0.52-0.574 OR 1.76 0.839-3.69 1.76 0.839-3.69 1.31 0.72-2.39 1.31 0.72-2.39 1.48 1.02-2.15 1.48 1.02-2.15 1.39 1.05-1.84 1.39 1.05-1.84 1.26 1.03-1.55 1.26 1.03-1.55 1.06 0.796-1.41 0.687 1.37 1.05-1.8 0.0225 1.45 1.1-1.89 0.00746 TRUE FALSE FALSE TRUE Female 473 4723 GRCh37/hg19 s=0.2;Lambda=0.006952 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000558/ScoringFiles/ phewas/PRSWEB_PHECODE184.11_Phelan-OCCC_LASSOSUM_UKB_20200608/all.tsv phewas/PRSWEB_PHECODE184.11_Phelan-OCCC_LASSOSUM_UKB_20200608/exclusion.tsv 2020-06-08 prsweb-phecode184-11-phelan-sioc-lassosum-ukb-20200608 prsweb-phecode184-11-phelan-sioc-lassosum-ukb-20200608 PRSWEB_PHECODE184.11_Phelan-SIOC_LASSOSUM_UKB_20200608 Lassosum PRSWEB_PHECODE184.11_Phelan-SIOC_LASSOSUM_UKB_20200608 184.11 Serous invasive ovarian cancer Binary Serous invasive ovarian cancer UKB UK Biobank lassosum Phelan CM et al. 2017 28346442 https://www.ncbi.nlm.nih.gov/pubmed/?term=28346442 110710 4.9e-05 0.0151106 0.0825 0.556 0.529-0.583 OR 1.76 0.839-3.69 1.76 0.839-3.69 1.64 0.949-2.84 1.64 0.949-2.84 1.48 1.02-2.15 1.48 1.02-2.15 1.73 1.33-2.25 1.73 1.33-2.25 1.42 1.16-1.74 1.42 1.16-1.74 1.23 0.922-1.63 0.161 1.3 0.978-1.73 0.0707 1.68 1.28-2.2 0.000181 TRUE FALSE FALSE TRUE Female 473 4723 GRCh37/hg19 s=0.9;Lambda=0.01129 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000564/ScoringFiles/ phewas/PRSWEB_PHECODE184.11_Phelan-SIOC_LASSOSUM_UKB_20200608/all.tsv phewas/PRSWEB_PHECODE184.11_Phelan-SIOC_LASSOSUM_UKB_20200608/exclusion.tsv 2020-06-08 prsweb-phecode185-20001-1044-p-5e-05-mgi-20200608 prsweb-phecode185-20001-1044-p-5e-05-mgi-20200608 PRSWEB_PHECODE185_20001-1044_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE185_20001-1044_P_5e-05_MGI_20200608 185 Cancer code, self-reported: prostate cancer Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 203 1.3e-22 0.0295084 0.152 0.591 0.573-0.611 OR 1.82 1.07-3.11 1.82 1.07-3.11 1.39 0.907-2.12 1.39 0.907-2.12 1.95 1.52-2.51 1.95 1.52-2.51 1.85 1.53-2.24 1.85 1.53-2.24 1.73 1.5-1.99 1.73 1.5-1.99 1.72 1.38-2.14 1.25e-06 1.91 1.54-2.36 2.47e-09 2.62 2.14-3.21 1.57e-20 TRUE FALSE FALSE FALSE Male 1190 4417 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode185-c3-prostate-p-5e-05-mgi-20200608 prsweb-phecode185-c3-prostate-p-5e-05-mgi-20200608 PRSWEB_PHECODE185_C3-PROSTATE_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE185_C3-PROSTATE_P_5e-05_MGI_20200608 185 Malignant neoplasm of prostate Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 290 7.7e-38 0.0604999 0.149 0.626 0.607-0.644 OR 2.41 1.45-4.01 2.41 1.45-4.01 2.53 1.77-3.62 2.53 1.77-3.62 2.26 1.77-2.89 2.26 1.77-2.89 2.14 1.78-2.58 2.14 1.78-2.58 2.21 1.92-2.54 2.21 1.92-2.54 1.12 0.886-1.41 0.351 1.95 1.58-2.41 5.79e-10 2.99 2.44-3.66 1.85e-26 TRUE FALSE FALSE FALSE Male 1190 4417 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode185-c61-p-5e-05-mgi-20200608 prsweb-phecode185-c61-p-5e-05-mgi-20200608 PRSWEB_PHECODE185_C61_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE185_C61_P_5e-05_MGI_20200608 185 Diagnoses - main ICD10: C61 Malignant neoplasm of prostate Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 256 6.9e-31 0.0475713 0.15 0.61 0.591-0.629 OR 2.22 1.36-3.63 2.22 1.36-3.63 2.96 2.1-4.17 2.96 2.1-4.17 2.33 1.83-2.97 2.33 1.83-2.97 2.18 1.81-2.62 2.18 1.81-2.62 1.93 1.67-2.22 1.93 1.67-2.22 1.47 1.18-1.83 0.000644 1.87 1.51-2.32 7.19e-09 2.77 2.26-3.39 7.65e-23 TRUE FALSE FALSE FALSE Male 1190 4417 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode185-gwas-catalog-r2019-05-03-x185-p-5e-05-mgi-20200608 prsweb-phecode185-gwas-catalog-r2019-05-03-x185-p-5e-05-mgi-20200608 PRSWEB_PHECODE185_GWAS-Catalog-r2019-05-03-X185_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE185_GWAS-Catalog-r2019-05-03-X185_P_5e-05_MGI_20200608 185 Prostate cancer;Prostate cancer (early onset) Binary 157 unique SNPs MGI Michigan Genomics Initiative Fixed threshold (5e-05) GWAS Catalog (2019-05-03) 17401363;17401366;17603485;18264096;18264097;18264098;19117981;19767754;21743057;21743467;23104005;23535732;24740154;25939597;27262462;29892016;30410027 https://www.ncbi.nlm.nih.gov/pubmed/?term=17401363+17401366+17603485+18264096+18264097+18264098+19117981+19767754+21743057+21743467+23104005+23535732+24740154+25939597+27262462+29892016+30410027 124 3.6e-53 0.0666721 0.147 0.646 0.627-0.664 OR 3.41 2.17-5.35 3.41 2.17-5.35 3.39 2.43-4.73 3.39 2.43-4.73 2.74 2.17-3.45 2.74 2.17-3.45 2.73 2.29-3.27 2.73 2.29-3.27 2.5 2.17-2.87 2.5 2.17-2.87 1.62 1.27-2.05 8.09e-05 2.38 1.9-2.99 4.88e-14 4.08 3.3-5.06 5.87e-38 TRUE FALSE FALSE FALSE Male 1190 4417 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode185-pca-practical-p-5e-05-mgi-20200608 prsweb-phecode185-pca-practical-p-5e-05-mgi-20200608 PRSWEB_PHECODE185_Pca-PRACTICAL_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE185_Pca-PRACTICAL_P_5e-05_MGI_20200608 185 Prostate cancer Binary "Meta analysis summary data Meta summary association statistics for overall Prostate Cancer, as described in Schumacher, Al Olama, Berndt, et al. 2018 are provided. Acknowledgements When using these data, please cite: Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci. Schumacher, Al Olama, Berndt, et al. Nature Genetics 2018, acknowledge “The PRACTICAL consortium, CRUK, BPC3, CAPS, PEGASUS”, and include the following: The Prostate cancer genome-wide association analyses are supported by the Canadian Institutes of Health Research, European Commission’s Seventh Framework Programme grant agreement n° 223175 (HEALTH-F2-2009-223175), Cancer Research UK Grants C5047/A7357, C1287/A10118, C1287/A16563, C5047/A3354, C5047/A10692, C16913/A6135, and The National Institute of Health (NIH) Cancer Post-Cancer GWAS initiative grant: No. 1 U19 CA 148537-01 (the GAME-ON initiative). We would also like to thank the following for funding support: The Institute of Cancer Research and The Everyman Campaign, The Prostate Cancer Research Foundation, Prostate Research Campaign UK (now Prostate Action), The Orchid Cancer Appeal, The National Cancer Research Network UK, The National Cancer Research Institute (NCRI) UK. We are grateful for support of NIHR funding to the NIHR Biomedical Research Centre at The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust. The Prostate Cancer Program of Cancer Council Victoria also acknowledge grant support from The National Health and Medical Research Council, Australia (126402, 209057, 251533, , 396414, 450104, 504700, 504702, 504715, 623204, 940394, 614296,), VicHealth, Cancer Council Victoria, The Prostate Cancer Foundation of Australia, The Whitten Foundation, PricewaterhouseCoopers, and Tattersall’s. EAO, DMK, and EMK acknowledge the Intramural Program of the National Human Genome Research Institute for their support. Genotyping of the OncoArray was funded by the US National Institutes of Health (NIH) [U19 CA 148537 for ELucidating Loci Involved in Prostate cancer SuscEptibility (ELLIPSE) project and X01HG007492 to the Center for Inherited Disease Research (CIDR) under contract number HHSN268201200008I] and by Cancer Research UK grant A8197/A16565. Additional analytic support was provided by NIH NCI U01 CA188392 (PI: Schumacher). Funding for the iCOGS infrastructure came from: the European Community’s Seventh Framework Programme under grant agreement n° 223175 (HEALTH-F2-2009-223175) (COGS), Cancer Research UK (C1287/A10118, C1287/A 10710, C12292/A11174, C1281/A12014, C5047/A8384, C5047/A15007, C5047/A10692, C8197/A16565), the National Institutes of Health (CA128978) and Post-Cancer GWAS initiative (1U19 CA148537, 1U19 CA148065 and 1U19 CA148112 – the GAME-ON initiative), the Department of Defence (W81XWH-10-1-0341), the Canadian Institutes of Health Research (CIHR) for the CIHR Team in Familial Risks of Breast Cancer, Komen Foundation for the Cure, the Breast Cancer Research Foundation, and the Ovarian Cancer Research Fund. The BPC3 was supported by the U.S. National Institutes of Health, National Cancer Institute (cooperative agreements U01-CA98233 to D.J.H., U01-CA98710 to S.M.G., U01-CA98216 toE.R., and U01-CA98758 to B.E.H., and Intramural Research Program of NIH/National Cancer Institute, Division of Cancer Epidemiology and Genetics). CAPS GWAS study was supported by the Swedish Cancer Foundation (grant no 09-0677, 11-484, 12-823), the Cancer Risk Prediction Center (CRisP; www.crispcenter.org), a Linneus Centre (Contract ID 70867902) financed by the Swedish Research Council, Swedish Research Council (grant no K2010-70X-20430-04-3, 2014-2269) PEGASUS was supported by the Intramural Research Program, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health. Kindly send a copy of any publication that results from these data to PRACTICAL@icr.ac.uk Terms of use The nature of the data provided should not allow identification of individual subjects. By downloading these data, you agree not to attempt to identify individual subjects, or repost these data to a third party website without permission." MGI Michigan Genomics Initiative Fixed threshold (5e-05) Schumacher FR et al. 2019 29892016 https://www.ncbi.nlm.nih.gov/pubmed/?term=29892016 1223 9.1e-65 0.0891174 0.145 0.668 0.651-0.685 OR 3.62 2.27-5.76 3.62 2.27-5.76 3.24 2.3-4.55 3.24 2.3-4.55 2.99 2.38-3.75 2.99 2.38-3.75 2.78 2.33-3.32 2.78 2.33-3.32 3.06 2.66-3.52 3.06 2.66-3.52 1.8 1.41-2.31 3.1e-06 2.44 1.92-3.1 2.54e-13 5.25 4.2-6.57 5.1e-48 TRUE FALSE FALSE FALSE Male 1190 4417 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode185-ukbb-saige-hrc-x185-p-5e-05-mgi-20200608 prsweb-phecode185-ukbb-saige-hrc-x185-p-5e-05-mgi-20200608 PRSWEB_PHECODE185_UKBB-SAIGE-HRC-X185_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE185_UKBB-SAIGE-HRC-X185_P_5e-05_MGI_20200608 185 Cancer of prostate Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 243 7.5e-35 0.0526162 0.15 0.616 0.598-0.634 OR 2.9 1.79-4.7 2.9 1.79-4.7 2.35 1.64-3.39 2.35 1.64-3.39 2.4 1.89-3.06 2.4 1.89-3.06 2.17 1.81-2.61 2.17 1.81-2.61 2.1 1.83-2.42 2.1 1.83-2.42 1.36 1.09-1.71 0.00746 1.83 1.48-2.27 2.23e-08 2.95 2.41-3.61 1.23e-25 TRUE FALSE FALSE FALSE Male 1190 4417 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode185-20001-1044-p-5e-06-mgi-20200608 prsweb-phecode185-20001-1044-p-5e-06-mgi-20200608 PRSWEB_PHECODE185_20001-1044_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE185_20001-1044_P_5e-06_MGI_20200608 185 Cancer code, self-reported: prostate cancer Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 56 2e-31 0.0397989 0.15 0.609 0.591-0.628 OR 3.37 2.14-5.3 3.37 2.14-5.3 3.05 2.18-4.28 3.05 2.18-4.28 2.31 1.82-2.94 2.31 1.82-2.94 2.17 1.81-2.61 2.17 1.81-2.61 1.85 1.6-2.13 1.85 1.6-2.13 1.6 1.28-2 3.07e-05 2.12 1.71-2.63 6.92e-12 2.9 2.36-3.57 1.03e-23 TRUE FALSE FALSE FALSE Male 1190 4417 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode185-c3-prostate-p-5e-06-mgi-20200608 prsweb-phecode185-c3-prostate-p-5e-06-mgi-20200608 PRSWEB_PHECODE185_C3-PROSTATE_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE185_C3-PROSTATE_P_5e-06_MGI_20200608 185 Malignant neoplasm of prostate Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 118 1.6e-44 0.0639707 0.148 0.633 0.615-0.651 OR 3.22 2.03-5.09 3.22 2.03-5.09 3.06 2.19-4.29 3.06 2.19-4.29 2.97 2.37-3.73 2.97 2.37-3.73 2.54 2.12-3.04 2.54 2.12-3.04 2.19 1.9-2.52 2.19 1.9-2.52 1.61 1.28-2.03 5.61e-05 2.23 1.79-2.79 1.22e-12 3.52 2.85-4.34 1.83e-31 TRUE FALSE FALSE FALSE Male 1190 4417 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode185-c61-p-5e-06-mgi-20200608 prsweb-phecode185-c61-p-5e-06-mgi-20200608 PRSWEB_PHECODE185_C61_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE185_C61_P_5e-06_MGI_20200608 185 Diagnoses - main ICD10: C61 Malignant neoplasm of prostate Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 80 2.6e-38 0.0566154 0.149 0.621 0.603-0.64 OR 2.65 1.63-4.3 2.65 1.63-4.3 2.88 2.04-4.08 2.88 2.04-4.08 2.59 2.05-3.27 2.59 2.05-3.27 2.41 2.01-2.89 2.41 2.01-2.89 2.02 1.75-2.32 2.02 1.75-2.32 1.44 1.15-1.8 0.00161 2.06 1.66-2.54 3.95e-11 3.02 2.46-3.72 9.37e-26 TRUE FALSE FALSE FALSE Male 1190 4417 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode185-gwas-catalog-r2019-05-03-x185-p-5e-06-mgi-20200608 prsweb-phecode185-gwas-catalog-r2019-05-03-x185-p-5e-06-mgi-20200608 PRSWEB_PHECODE185_GWAS-Catalog-r2019-05-03-X185_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE185_GWAS-Catalog-r2019-05-03-X185_P_5e-06_MGI_20200608 185 Prostate cancer;Prostate cancer (early onset) Binary 157 unique SNPs MGI Michigan Genomics Initiative Fixed threshold (5e-06) GWAS Catalog (2019-05-03) 17401363;17401366;17603485;18264096;18264097;18264098;19117981;19767754;21743057;21743467;23104005;23535732;24740154;25939597;27262462;29892016;30410027 https://www.ncbi.nlm.nih.gov/pubmed/?term=17401363+17401366+17603485+18264096+18264097+18264098+19117981+19767754+21743057+21743467+23104005+23535732+24740154+25939597+27262462+29892016+30410027 124 3.6e-53 0.0666721 0.147 0.646 0.627-0.664 OR 3.41 2.17-5.35 3.41 2.17-5.35 3.39 2.43-4.73 3.39 2.43-4.73 2.74 2.17-3.45 2.74 2.17-3.45 2.73 2.29-3.27 2.73 2.29-3.27 2.5 2.17-2.87 2.5 2.17-2.87 1.62 1.27-2.05 8.09e-05 2.38 1.9-2.99 4.88e-14 4.08 3.3-5.06 5.87e-38 TRUE FALSE FALSE FALSE Male 1190 4417 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode185-pca-practical-p-5e-06-mgi-20200608 prsweb-phecode185-pca-practical-p-5e-06-mgi-20200608 PRSWEB_PHECODE185_Pca-PRACTICAL_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE185_Pca-PRACTICAL_P_5e-06_MGI_20200608 185 Prostate cancer Binary "Meta analysis summary data Meta summary association statistics for overall Prostate Cancer, as described in Schumacher, Al Olama, Berndt, et al. 2018 are provided. Acknowledgements When using these data, please cite: Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci. Schumacher, Al Olama, Berndt, et al. Nature Genetics 2018, acknowledge “The PRACTICAL consortium, CRUK, BPC3, CAPS, PEGASUS”, and include the following: The Prostate cancer genome-wide association analyses are supported by the Canadian Institutes of Health Research, European Commission’s Seventh Framework Programme grant agreement n° 223175 (HEALTH-F2-2009-223175), Cancer Research UK Grants C5047/A7357, C1287/A10118, C1287/A16563, C5047/A3354, C5047/A10692, C16913/A6135, and The National Institute of Health (NIH) Cancer Post-Cancer GWAS initiative grant: No. 1 U19 CA 148537-01 (the GAME-ON initiative). We would also like to thank the following for funding support: The Institute of Cancer Research and The Everyman Campaign, The Prostate Cancer Research Foundation, Prostate Research Campaign UK (now Prostate Action), The Orchid Cancer Appeal, The National Cancer Research Network UK, The National Cancer Research Institute (NCRI) UK. We are grateful for support of NIHR funding to the NIHR Biomedical Research Centre at The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust. The Prostate Cancer Program of Cancer Council Victoria also acknowledge grant support from The National Health and Medical Research Council, Australia (126402, 209057, 251533, , 396414, 450104, 504700, 504702, 504715, 623204, 940394, 614296,), VicHealth, Cancer Council Victoria, The Prostate Cancer Foundation of Australia, The Whitten Foundation, PricewaterhouseCoopers, and Tattersall’s. EAO, DMK, and EMK acknowledge the Intramural Program of the National Human Genome Research Institute for their support. Genotyping of the OncoArray was funded by the US National Institutes of Health (NIH) [U19 CA 148537 for ELucidating Loci Involved in Prostate cancer SuscEptibility (ELLIPSE) project and X01HG007492 to the Center for Inherited Disease Research (CIDR) under contract number HHSN268201200008I] and by Cancer Research UK grant A8197/A16565. Additional analytic support was provided by NIH NCI U01 CA188392 (PI: Schumacher). Funding for the iCOGS infrastructure came from: the European Community’s Seventh Framework Programme under grant agreement n° 223175 (HEALTH-F2-2009-223175) (COGS), Cancer Research UK (C1287/A10118, C1287/A 10710, C12292/A11174, C1281/A12014, C5047/A8384, C5047/A15007, C5047/A10692, C8197/A16565), the National Institutes of Health (CA128978) and Post-Cancer GWAS initiative (1U19 CA148537, 1U19 CA148065 and 1U19 CA148112 – the GAME-ON initiative), the Department of Defence (W81XWH-10-1-0341), the Canadian Institutes of Health Research (CIHR) for the CIHR Team in Familial Risks of Breast Cancer, Komen Foundation for the Cure, the Breast Cancer Research Foundation, and the Ovarian Cancer Research Fund. The BPC3 was supported by the U.S. National Institutes of Health, National Cancer Institute (cooperative agreements U01-CA98233 to D.J.H., U01-CA98710 to S.M.G., U01-CA98216 toE.R., and U01-CA98758 to B.E.H., and Intramural Research Program of NIH/National Cancer Institute, Division of Cancer Epidemiology and Genetics). CAPS GWAS study was supported by the Swedish Cancer Foundation (grant no 09-0677, 11-484, 12-823), the Cancer Risk Prediction Center (CRisP; www.crispcenter.org), a Linneus Centre (Contract ID 70867902) financed by the Swedish Research Council, Swedish Research Council (grant no K2010-70X-20430-04-3, 2014-2269) PEGASUS was supported by the Intramural Research Program, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health. Kindly send a copy of any publication that results from these data to PRACTICAL@icr.ac.uk Terms of use The nature of the data provided should not allow identification of individual subjects. By downloading these data, you agree not to attempt to identify individual subjects, or repost these data to a third party website without permission." MGI Michigan Genomics Initiative Fixed threshold (5e-06) Schumacher FR et al. 2019 29892016 https://www.ncbi.nlm.nih.gov/pubmed/?term=29892016 691 3.1e-63 0.0849946 0.145 0.666 0.649-0.683 OR 4.51 2.94-6.94 4.51 2.94-6.94 4.3 3.12-5.92 4.3 3.12-5.92 2.81 2.24-3.54 2.81 2.24-3.54 2.79 2.34-3.33 2.79 2.34-3.33 2.9 2.52-3.34 2.9 2.52-3.34 1.6 1.25-2.05 0.000188 2.56 2.03-3.24 3.46e-15 4.9 3.93-6.1 1.35e-45 TRUE FALSE FALSE FALSE Male 1190 4417 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode185-ukbb-saige-hrc-x185-p-5e-06-mgi-20200608 prsweb-phecode185-ukbb-saige-hrc-x185-p-5e-06-mgi-20200608 PRSWEB_PHECODE185_UKBB-SAIGE-HRC-X185_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE185_UKBB-SAIGE-HRC-X185_P_5e-06_MGI_20200608 185 Cancer of prostate Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 110 3e-41 0.0592476 0.149 0.628 0.61-0.647 OR 3.55 2.26-5.58 3.55 2.26-5.58 2.79 1.97-3.94 2.79 1.97-3.94 2.78 2.2-3.51 2.78 2.2-3.51 2.51 2.1-3 2.51 2.1-3 2.16 1.88-2.49 2.16 1.88-2.49 1.39 1.1-1.76 0.00578 2.16 1.75-2.68 1.7e-12 3.24 2.63-3.98 5.8e-29 TRUE FALSE FALSE FALSE Male 1190 4417 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode185-20001-1044-p-5e-07-mgi-20200608 prsweb-phecode185-20001-1044-p-5e-07-mgi-20200608 PRSWEB_PHECODE185_20001-1044_P_5e-07_MGI_20200608 P_5e-07 PRSWEB_PHECODE185_20001-1044_P_5e-07_MGI_20200608 185 Cancer code, self-reported: prostate cancer Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-07) UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 32 7.3e-29 0.0374154 0.151 0.607 0.59-0.626 OR 2.83 1.76-4.53 2.83 1.76-4.53 2.48 1.73-3.55 2.48 1.73-3.55 1.98 1.54-2.54 1.98 1.54-2.54 1.87 1.55-2.26 1.87 1.55-2.26 1.73 1.5-2 1.73 1.5-2 1.43 1.14-1.79 0.00175 2.25 1.82-2.77 3.01e-14 2.71 2.2-3.33 2.84e-21 TRUE FALSE FALSE FALSE Male 1190 4417 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode185-c3-prostate-p-5e-07-mgi-20200608 prsweb-phecode185-c3-prostate-p-5e-07-mgi-20200608 PRSWEB_PHECODE185_C3-PROSTATE_P_5e-07_MGI_20200608 P_5e-07 PRSWEB_PHECODE185_C3-PROSTATE_P_5e-07_MGI_20200608 185 Malignant neoplasm of prostate Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-07) UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 67 1.8e-47 0.0614117 0.148 0.638 0.62-0.656 OR 3.69 2.36-5.75 3.69 2.36-5.75 2.71 1.92-3.83 2.71 1.92-3.83 2.98 2.37-3.75 2.98 2.37-3.75 2.6 2.17-3.11 2.6 2.17-3.11 2.43 2.11-2.8 2.43 2.11-2.8 1.5 1.19-1.89 0.000563 1.99 1.6-2.48 8.2e-10 3.61 2.93-4.45 1.62e-33 TRUE FALSE FALSE FALSE Male 1190 4417 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode185-c61-p-5e-07-mgi-20200608 prsweb-phecode185-c61-p-5e-07-mgi-20200608 PRSWEB_PHECODE185_C61_P_5e-07_MGI_20200608 P_5e-07 PRSWEB_PHECODE185_C61_P_5e-07_MGI_20200608 185 Diagnoses - main ICD10: C61 Malignant neoplasm of prostate Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-07) UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 47 5e-37 0.0626774 0.149 0.619 0.601-0.637 OR 3.1 1.96-4.92 3.1 1.96-4.92 2.88 2.04-4.06 2.88 2.04-4.06 2.59 2.05-3.27 2.59 2.05-3.27 2.18 1.82-2.62 2.18 1.82-2.62 1.95 1.69-2.24 1.95 1.69-2.24 1.56 1.24-1.95 0.000138 2.24 1.81-2.77 1.63e-13 3.11 2.53-3.83 8.39e-27 TRUE FALSE FALSE FALSE Male 1190 4417 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode185-gwas-catalog-r2019-05-03-x185-p-5e-07-mgi-20200608 prsweb-phecode185-gwas-catalog-r2019-05-03-x185-p-5e-07-mgi-20200608 PRSWEB_PHECODE185_GWAS-Catalog-r2019-05-03-X185_P_5e-07_MGI_20200608 P_5e-07 PRSWEB_PHECODE185_GWAS-Catalog-r2019-05-03-X185_P_5e-07_MGI_20200608 185 Prostate cancer;Prostate cancer (early onset) Binary 157 unique SNPs MGI Michigan Genomics Initiative Fixed threshold (5e-07) GWAS Catalog (2019-05-03) 17401363;17401366;17603485;18264096;18264097;18264098;19117981;19767754;21743057;21743467;23104005;23535732;24740154;25939597;27262462;29892016;30410027 https://www.ncbi.nlm.nih.gov/pubmed/?term=17401363+17401366+17603485+18264096+18264097+18264098+19117981+19767754+21743057+21743467+23104005+23535732+24740154+25939597+27262462+29892016+30410027 123 7e-53 0.066706 0.147 0.646 0.627-0.663 OR 3.64 2.33-5.68 3.64 2.33-5.68 3.44 2.47-4.81 3.44 2.47-4.81 2.68 2.12-3.38 2.68 2.12-3.38 2.69 2.25-3.22 2.69 2.25-3.22 2.52 2.19-2.9 2.52 2.19-2.9 1.68 1.33-2.14 1.82e-05 2.38 1.89-2.99 9.14e-14 4.17 3.36-5.17 9.7e-39 TRUE FALSE FALSE FALSE Male 1190 4417 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode185-pca-practical-p-5e-07-mgi-20200608 prsweb-phecode185-pca-practical-p-5e-07-mgi-20200608 PRSWEB_PHECODE185_Pca-PRACTICAL_P_5e-07_MGI_20200608 P_5e-07 PRSWEB_PHECODE185_Pca-PRACTICAL_P_5e-07_MGI_20200608 185 Prostate cancer Binary "Meta analysis summary data Meta summary association statistics for overall Prostate Cancer, as described in Schumacher, Al Olama, Berndt, et al. 2018 are provided. Acknowledgements When using these data, please cite: Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci. Schumacher, Al Olama, Berndt, et al. Nature Genetics 2018, acknowledge “The PRACTICAL consortium, CRUK, BPC3, CAPS, PEGASUS”, and include the following: The Prostate cancer genome-wide association analyses are supported by the Canadian Institutes of Health Research, European Commission’s Seventh Framework Programme grant agreement n° 223175 (HEALTH-F2-2009-223175), Cancer Research UK Grants C5047/A7357, C1287/A10118, C1287/A16563, C5047/A3354, C5047/A10692, C16913/A6135, and The National Institute of Health (NIH) Cancer Post-Cancer GWAS initiative grant: No. 1 U19 CA 148537-01 (the GAME-ON initiative). We would also like to thank the following for funding support: The Institute of Cancer Research and The Everyman Campaign, The Prostate Cancer Research Foundation, Prostate Research Campaign UK (now Prostate Action), The Orchid Cancer Appeal, The National Cancer Research Network UK, The National Cancer Research Institute (NCRI) UK. We are grateful for support of NIHR funding to the NIHR Biomedical Research Centre at The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust. The Prostate Cancer Program of Cancer Council Victoria also acknowledge grant support from The National Health and Medical Research Council, Australia (126402, 209057, 251533, , 396414, 450104, 504700, 504702, 504715, 623204, 940394, 614296,), VicHealth, Cancer Council Victoria, The Prostate Cancer Foundation of Australia, The Whitten Foundation, PricewaterhouseCoopers, and Tattersall’s. EAO, DMK, and EMK acknowledge the Intramural Program of the National Human Genome Research Institute for their support. Genotyping of the OncoArray was funded by the US National Institutes of Health (NIH) [U19 CA 148537 for ELucidating Loci Involved in Prostate cancer SuscEptibility (ELLIPSE) project and X01HG007492 to the Center for Inherited Disease Research (CIDR) under contract number HHSN268201200008I] and by Cancer Research UK grant A8197/A16565. Additional analytic support was provided by NIH NCI U01 CA188392 (PI: Schumacher). Funding for the iCOGS infrastructure came from: the European Community’s Seventh Framework Programme under grant agreement n° 223175 (HEALTH-F2-2009-223175) (COGS), Cancer Research UK (C1287/A10118, C1287/A 10710, C12292/A11174, C1281/A12014, C5047/A8384, C5047/A15007, C5047/A10692, C8197/A16565), the National Institutes of Health (CA128978) and Post-Cancer GWAS initiative (1U19 CA148537, 1U19 CA148065 and 1U19 CA148112 – the GAME-ON initiative), the Department of Defence (W81XWH-10-1-0341), the Canadian Institutes of Health Research (CIHR) for the CIHR Team in Familial Risks of Breast Cancer, Komen Foundation for the Cure, the Breast Cancer Research Foundation, and the Ovarian Cancer Research Fund. The BPC3 was supported by the U.S. National Institutes of Health, National Cancer Institute (cooperative agreements U01-CA98233 to D.J.H., U01-CA98710 to S.M.G., U01-CA98216 toE.R., and U01-CA98758 to B.E.H., and Intramural Research Program of NIH/National Cancer Institute, Division of Cancer Epidemiology and Genetics). CAPS GWAS study was supported by the Swedish Cancer Foundation (grant no 09-0677, 11-484, 12-823), the Cancer Risk Prediction Center (CRisP; www.crispcenter.org), a Linneus Centre (Contract ID 70867902) financed by the Swedish Research Council, Swedish Research Council (grant no K2010-70X-20430-04-3, 2014-2269) PEGASUS was supported by the Intramural Research Program, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health. Kindly send a copy of any publication that results from these data to PRACTICAL@icr.ac.uk Terms of use The nature of the data provided should not allow identification of individual subjects. By downloading these data, you agree not to attempt to identify individual subjects, or repost these data to a third party website without permission." MGI Michigan Genomics Initiative Fixed threshold (5e-07) Schumacher FR et al. 2019 29892016 https://www.ncbi.nlm.nih.gov/pubmed/?term=29892016 492 2e-56 0.0877555 0.146 0.653 0.636-0.673 OR 4.62 2.99-7.13 4.62 2.99-7.13 3.47 2.49-4.82 3.47 2.49-4.82 2.76 2.19-3.48 2.76 2.19-3.48 2.68 2.24-3.2 2.68 2.24-3.2 2.67 2.32-3.07 2.67 2.32-3.07 1.79 1.41-2.28 1.82e-06 2.34 1.85-2.95 1.2e-12 4.5 3.61-5.59 1.82e-41 TRUE FALSE FALSE FALSE Male 1190 4417 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode185-ukbb-saige-hrc-x185-p-5e-07-mgi-20200608 prsweb-phecode185-ukbb-saige-hrc-x185-p-5e-07-mgi-20200608 PRSWEB_PHECODE185_UKBB-SAIGE-HRC-X185_P_5e-07_MGI_20200608 P_5e-07 PRSWEB_PHECODE185_UKBB-SAIGE-HRC-X185_P_5e-07_MGI_20200608 185 Cancer of prostate Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative Fixed threshold (5e-07) UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 64 2.6e-43 0.0576157 0.148 0.631 0.612-0.649 OR 3.8 2.44-5.92 3.8 2.44-5.92 3.87 2.8-5.35 3.87 2.8-5.35 2.94 2.33-3.7 2.94 2.33-3.7 2.36 1.97-2.83 2.36 1.97-2.83 2.15 1.87-2.47 2.15 1.87-2.47 1.22 0.972-1.54 0.0867 2.08 1.68-2.57 1.22e-11 3.09 2.52-3.79 2.46e-27 TRUE FALSE FALSE FALSE Male 1190 4417 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode185-20001-1044-p-5e-09-mgi-20200608 prsweb-phecode185-20001-1044-p-5e-09-mgi-20200608 PRSWEB_PHECODE185_20001-1044_P_5e-09_MGI_20200608 P_5e-09 PRSWEB_PHECODE185_20001-1044_P_5e-09_MGI_20200608 185 Cancer code, self-reported: prostate cancer Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-09) UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 14 3.7e-24 0.0350443 0.151 0.591 0.573-0.61 OR 1.67 0.971-2.87 1.67 0.971-2.87 2.47 1.72-3.55 2.47 1.72-3.55 2.08 1.62-2.68 2.08 1.62-2.68 1.75 1.44-2.13 1.75 1.44-2.13 1.8 1.56-2.07 1.8 1.56-2.07 1.38 1.11-1.71 0.00347 1.74 1.41-2.14 2.01e-07 2.49 2.03-3.05 1.08e-18 TRUE FALSE FALSE FALSE Male 1190 4417 GRCh37/hg19 P<=5e-09 2020-06-08 prsweb-phecode185-c3-prostate-p-5e-09-mgi-20200608 prsweb-phecode185-c3-prostate-p-5e-09-mgi-20200608 PRSWEB_PHECODE185_C3-PROSTATE_P_5e-09_MGI_20200608 P_5e-09 PRSWEB_PHECODE185_C3-PROSTATE_P_5e-09_MGI_20200608 185 Malignant neoplasm of prostate Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-09) UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 43 2.1e-39 0.0561884 0.149 0.624 0.605-0.642 OR 3.06 1.93-4.85 3.06 1.93-4.85 2.96 2.1-4.19 2.96 2.1-4.19 2.53 1.99-3.2 2.53 1.99-3.2 2.42 2.02-2.89 2.42 2.02-2.89 2.03 1.76-2.34 2.03 1.76-2.34 1.48 1.18-1.85 0.00066 2.06 1.66-2.55 3.25e-11 3.08 2.5-3.78 1.02e-26 TRUE FALSE FALSE FALSE Male 1190 4417 GRCh37/hg19 P<=5e-09 2020-06-08 prsweb-phecode185-c61-p-5e-09-mgi-20200608 prsweb-phecode185-c61-p-5e-09-mgi-20200608 PRSWEB_PHECODE185_C61_P_5e-09_MGI_20200608 P_5e-09 PRSWEB_PHECODE185_C61_P_5e-09_MGI_20200608 185 Diagnoses - main ICD10: C61 Malignant neoplasm of prostate Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-09) UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 21 2.1e-33 0.0466292 0.15 0.61 0.591-0.628 OR 2.64 1.63-4.27 2.64 1.63-4.27 2.55 1.78-3.64 2.55 1.78-3.64 2.54 2-3.22 2.54 2-3.22 2.22 1.85-2.67 2.22 1.85-2.67 1.93 1.67-2.22 1.93 1.67-2.22 1.55 1.25-1.92 7.69e-05 1.78 1.44-2.2 9.36e-08 2.84 2.31-3.47 8.89e-24 TRUE FALSE FALSE FALSE Male 1190 4417 GRCh37/hg19 P<=5e-09 2020-06-08 prsweb-phecode185-gwas-catalog-r2019-05-03-x185-p-5e-09-mgi-20200608 prsweb-phecode185-gwas-catalog-r2019-05-03-x185-p-5e-09-mgi-20200608 PRSWEB_PHECODE185_GWAS-Catalog-r2019-05-03-X185_P_5e-09_MGI_20200608 P_5e-09 PRSWEB_PHECODE185_GWAS-Catalog-r2019-05-03-X185_P_5e-09_MGI_20200608 185 Prostate cancer;Prostate cancer (early onset) Binary 157 unique SNPs MGI Michigan Genomics Initiative Fixed threshold (5e-09) GWAS Catalog (2019-05-03) 17401363;17401366;17603485;18264096;18264097;18264098;19117981;19767754;21743057;21743467;23104005;23535732;24740154;25939597;27262462;29892016;30410027 https://www.ncbi.nlm.nih.gov/pubmed/?term=17401363+17401366+17603485+18264096+18264097+18264098+19117981+19767754+21743057+21743467+23104005+23535732+24740154+25939597+27262462+29892016+30410027 86 4.3e-51 0.0563016 0.147 0.643 0.625-0.661 OR 2.97 1.85-4.75 2.97 1.85-4.75 3.11 2.22-4.35 3.11 2.22-4.35 2.62 2.08-3.3 2.62 2.08-3.3 2.55 2.13-3.05 2.55 2.13-3.05 2.43 2.11-2.8 2.43 2.11-2.8 1.6 1.26-2.03 0.000131 2.4 1.92-3.01 1.79e-14 4.07 3.27-5.05 9.39e-37 TRUE FALSE FALSE FALSE Male 1190 4417 GRCh37/hg19 P<=5e-09 2020-06-08 prsweb-phecode185-pca-practical-p-5e-09-mgi-20200608 prsweb-phecode185-pca-practical-p-5e-09-mgi-20200608 PRSWEB_PHECODE185_Pca-PRACTICAL_P_5e-09_MGI_20200608 P_5e-09 PRSWEB_PHECODE185_Pca-PRACTICAL_P_5e-09_MGI_20200608 185 Prostate cancer Binary "Meta analysis summary data Meta summary association statistics for overall Prostate Cancer, as described in Schumacher, Al Olama, Berndt, et al. 2018 are provided. Acknowledgements When using these data, please cite: Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci. Schumacher, Al Olama, Berndt, et al. Nature Genetics 2018, acknowledge “The PRACTICAL consortium, CRUK, BPC3, CAPS, PEGASUS”, and include the following: The Prostate cancer genome-wide association analyses are supported by the Canadian Institutes of Health Research, European Commission’s Seventh Framework Programme grant agreement n° 223175 (HEALTH-F2-2009-223175), Cancer Research UK Grants C5047/A7357, C1287/A10118, C1287/A16563, C5047/A3354, C5047/A10692, C16913/A6135, and The National Institute of Health (NIH) Cancer Post-Cancer GWAS initiative grant: No. 1 U19 CA 148537-01 (the GAME-ON initiative). We would also like to thank the following for funding support: The Institute of Cancer Research and The Everyman Campaign, The Prostate Cancer Research Foundation, Prostate Research Campaign UK (now Prostate Action), The Orchid Cancer Appeal, The National Cancer Research Network UK, The National Cancer Research Institute (NCRI) UK. We are grateful for support of NIHR funding to the NIHR Biomedical Research Centre at The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust. The Prostate Cancer Program of Cancer Council Victoria also acknowledge grant support from The National Health and Medical Research Council, Australia (126402, 209057, 251533, , 396414, 450104, 504700, 504702, 504715, 623204, 940394, 614296,), VicHealth, Cancer Council Victoria, The Prostate Cancer Foundation of Australia, The Whitten Foundation, PricewaterhouseCoopers, and Tattersall’s. EAO, DMK, and EMK acknowledge the Intramural Program of the National Human Genome Research Institute for their support. Genotyping of the OncoArray was funded by the US National Institutes of Health (NIH) [U19 CA 148537 for ELucidating Loci Involved in Prostate cancer SuscEptibility (ELLIPSE) project and X01HG007492 to the Center for Inherited Disease Research (CIDR) under contract number HHSN268201200008I] and by Cancer Research UK grant A8197/A16565. Additional analytic support was provided by NIH NCI U01 CA188392 (PI: Schumacher). Funding for the iCOGS infrastructure came from: the European Community’s Seventh Framework Programme under grant agreement n° 223175 (HEALTH-F2-2009-223175) (COGS), Cancer Research UK (C1287/A10118, C1287/A 10710, C12292/A11174, C1281/A12014, C5047/A8384, C5047/A15007, C5047/A10692, C8197/A16565), the National Institutes of Health (CA128978) and Post-Cancer GWAS initiative (1U19 CA148537, 1U19 CA148065 and 1U19 CA148112 – the GAME-ON initiative), the Department of Defence (W81XWH-10-1-0341), the Canadian Institutes of Health Research (CIHR) for the CIHR Team in Familial Risks of Breast Cancer, Komen Foundation for the Cure, the Breast Cancer Research Foundation, and the Ovarian Cancer Research Fund. The BPC3 was supported by the U.S. National Institutes of Health, National Cancer Institute (cooperative agreements U01-CA98233 to D.J.H., U01-CA98710 to S.M.G., U01-CA98216 toE.R., and U01-CA98758 to B.E.H., and Intramural Research Program of NIH/National Cancer Institute, Division of Cancer Epidemiology and Genetics). CAPS GWAS study was supported by the Swedish Cancer Foundation (grant no 09-0677, 11-484, 12-823), the Cancer Risk Prediction Center (CRisP; www.crispcenter.org), a Linneus Centre (Contract ID 70867902) financed by the Swedish Research Council, Swedish Research Council (grant no K2010-70X-20430-04-3, 2014-2269) PEGASUS was supported by the Intramural Research Program, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health. Kindly send a copy of any publication that results from these data to PRACTICAL@icr.ac.uk Terms of use The nature of the data provided should not allow identification of individual subjects. By downloading these data, you agree not to attempt to identify individual subjects, or repost these data to a third party website without permission." MGI Michigan Genomics Initiative Fixed threshold (5e-09) Schumacher FR et al. 2019 29892016 https://www.ncbi.nlm.nih.gov/pubmed/?term=29892016 293 1.4e-54 0.0817148 0.146 0.648 0.63-0.665 OR 3.99 2.57-6.21 3.99 2.57-6.21 3.24 2.31-4.54 3.24 2.31-4.54 3.06 2.44-3.84 3.06 2.44-3.84 2.73 2.29-3.26 2.73 2.29-3.26 2.63 2.28-3.03 2.63 2.28-3.03 1.92 1.51-2.44 8.25e-08 2.27 1.79-2.87 8.14e-12 4.52 3.62-5.64 8.75e-41 TRUE FALSE FALSE FALSE Male 1190 4417 GRCh37/hg19 P<=5e-09 2020-06-08 prsweb-phecode185-ukbb-saige-hrc-x185-p-5e-09-mgi-20200608 prsweb-phecode185-ukbb-saige-hrc-x185-p-5e-09-mgi-20200608 PRSWEB_PHECODE185_UKBB-SAIGE-HRC-X185_P_5e-09_MGI_20200608 P_5e-09 PRSWEB_PHECODE185_UKBB-SAIGE-HRC-X185_P_5e-09_MGI_20200608 185 Cancer of prostate Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative Fixed threshold (5e-09) UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 32 1e-40 0.0519668 0.149 0.627 0.609-0.644 OR 2.51 1.54-4.07 2.51 1.54-4.07 2.93 2.08-4.12 2.93 2.08-4.12 2.52 1.99-3.2 2.52 1.99-3.2 2.31 1.93-2.78 2.31 1.93-2.78 2.12 1.84-2.44 2.12 1.84-2.44 1.37 1.09-1.73 0.00683 2.19 1.77-2.71 6e-13 3.23 2.62-3.97 1.24e-28 TRUE FALSE FALSE FALSE Male 1190 4417 GRCh37/hg19 P<=5e-09 2020-06-08 prsweb-phecode185-20001-1044-p-5e-08-mgi-20200608 prsweb-phecode185-20001-1044-p-5e-08-mgi-20200608 PRSWEB_PHECODE185_20001-1044_P_5e-08_MGI_20200608 P_5e-08 PRSWEB_PHECODE185_20001-1044_P_5e-08_MGI_20200608 185 Cancer code, self-reported: prostate cancer Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative GWAS Hits UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 21 3.3e-23 0.0330165 0.151 0.596 0.579-0.615 OR 2.39 1.41-4.03 2.39 1.41-4.03 2.83 1.99-4.04 2.83 1.99-4.04 2.06 1.61-2.65 2.06 1.61-2.65 1.85 1.53-2.25 1.85 1.53-2.25 1.73 1.5-2 1.73 1.5-2 1.46 1.18-1.81 0.000516 1.78 1.44-2.18 5.49e-08 2.45 2-3 2.54e-18 TRUE FALSE FALSE TRUE Male 1190 4417 GRCh37/hg19 P<=5e-08 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000565/ScoringFiles/ phewas/PRSWEB_PHECODE185_20001-1044_P_5e-08_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE185_20001-1044_P_5e-08_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode185-c3-prostate-p-5e-08-mgi-20200608 prsweb-phecode185-c3-prostate-p-5e-08-mgi-20200608 PRSWEB_PHECODE185_C3-PROSTATE_P_5e-08_MGI_20200608 P_5e-08 PRSWEB_PHECODE185_C3-PROSTATE_P_5e-08_MGI_20200608 185 Malignant neoplasm of prostate Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative GWAS Hits UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 49 3.5e-43 0.0562038 0.148 0.63 0.613-0.648 OR 2.86 1.79-4.57 2.86 1.79-4.57 3.35 2.39-4.69 3.35 2.39-4.69 2.8 2.22-3.53 2.8 2.22-3.53 2.49 2.08-2.98 2.49 2.08-2.98 2.17 1.88-2.5 2.17 1.88-2.5 1.42 1.13-1.79 0.00241 1.99 1.61-2.47 3.06e-10 3.18 2.59-3.9 2.14e-28 TRUE FALSE FALSE TRUE Male 1190 4417 GRCh37/hg19 P<=5e-08 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000569/ScoringFiles/ phewas/PRSWEB_PHECODE185_C3-PROSTATE_P_5e-08_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE185_C3-PROSTATE_P_5e-08_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode185-c61-p-5e-08-mgi-20200608 prsweb-phecode185-c61-p-5e-08-mgi-20200608 PRSWEB_PHECODE185_C61_P_5e-08_MGI_20200608 P_5e-08 PRSWEB_PHECODE185_C61_P_5e-08_MGI_20200608 185 Diagnoses - main ICD10: C61 Malignant neoplasm of prostate Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative GWAS Hits UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 31 2.6e-40 0.054533 0.149 0.622 0.603-0.641 OR 2.93 1.83-4.7 2.93 1.83-4.7 3.01 2.14-4.22 3.01 2.14-4.22 2.97 2.36-3.72 2.97 2.36-3.72 2.39 2-2.87 2.39 2-2.87 2.07 1.8-2.39 2.07 1.8-2.39 1.34 1.07-1.67 0.0106 1.86 1.51-2.3 7.99e-09 2.94 2.4-3.6 1.71e-25 TRUE FALSE FALSE TRUE Male 1190 4417 GRCh37/hg19 P<=5e-08 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000573/ScoringFiles/ phewas/PRSWEB_PHECODE185_C61_P_5e-08_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE185_C61_P_5e-08_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode185-gwas-catalog-r2019-05-03-x185-p-5e-08-mgi-20200608 prsweb-phecode185-gwas-catalog-r2019-05-03-x185-p-5e-08-mgi-20200608 PRSWEB_PHECODE185_GWAS-Catalog-r2019-05-03-X185_P_5e-08_MGI_20200608 P_5e-08 PRSWEB_PHECODE185_GWAS-Catalog-r2019-05-03-X185_P_5e-08_MGI_20200608 185 Prostate cancer;Prostate cancer (early onset) Binary 157 unique SNPs MGI Michigan Genomics Initiative GWAS Hits GWAS Catalog (2019-05-03) 17401363;17401366;17603485;18264096;18264097;18264098;19117981;19767754;21743057;21743467;23104005;23535732;24740154;25939597;27262462;29892016;30410027 https://www.ncbi.nlm.nih.gov/pubmed/?term=17401363+17401366+17603485+18264096+18264097+18264098+19117981+19767754+21743057+21743467+23104005+23535732+24740154+25939597+27262462+29892016+30410027 117 1.9e-53 0.062802 0.147 0.646 0.627-0.665 OR 3.57 2.29-5.57 3.57 2.29-5.57 2.91 2.06-4.1 2.91 2.06-4.1 2.97 2.36-3.73 2.97 2.36-3.73 2.75 2.3-3.29 2.75 2.3-3.29 2.66 2.31-3.06 2.66 2.31-3.06 1.39 1.1-1.76 0.00637 2.1 1.68-2.62 5.67e-11 3.92 3.18-4.83 1.01e-37 TRUE FALSE FALSE TRUE Male 1190 4417 GRCh37/hg19 P<=5e-08 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000577/ScoringFiles/ phewas/PRSWEB_PHECODE185_GWAS-Catalog-r2019-05-03-X185_P_5e-08_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE185_GWAS-Catalog-r2019-05-03-X185_P_5e-08_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode185-pca-practical-p-5e-08-mgi-20200608 prsweb-phecode185-pca-practical-p-5e-08-mgi-20200608 PRSWEB_PHECODE185_Pca-PRACTICAL_P_5e-08_MGI_20200608 P_5e-08 PRSWEB_PHECODE185_Pca-PRACTICAL_P_5e-08_MGI_20200608 185 Prostate cancer Binary "Meta analysis summary data Meta summary association statistics for overall Prostate Cancer, as described in Schumacher, Al Olama, Berndt, et al. 2018 are provided. Acknowledgements When using these data, please cite: Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci. Schumacher, Al Olama, Berndt, et al. Nature Genetics 2018, acknowledge “The PRACTICAL consortium, CRUK, BPC3, CAPS, PEGASUS”, and include the following: The Prostate cancer genome-wide association analyses are supported by the Canadian Institutes of Health Research, European Commission’s Seventh Framework Programme grant agreement n° 223175 (HEALTH-F2-2009-223175), Cancer Research UK Grants C5047/A7357, C1287/A10118, C1287/A16563, C5047/A3354, C5047/A10692, C16913/A6135, and The National Institute of Health (NIH) Cancer Post-Cancer GWAS initiative grant: No. 1 U19 CA 148537-01 (the GAME-ON initiative). We would also like to thank the following for funding support: The Institute of Cancer Research and The Everyman Campaign, The Prostate Cancer Research Foundation, Prostate Research Campaign UK (now Prostate Action), The Orchid Cancer Appeal, The National Cancer Research Network UK, The National Cancer Research Institute (NCRI) UK. We are grateful for support of NIHR funding to the NIHR Biomedical Research Centre at The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust. The Prostate Cancer Program of Cancer Council Victoria also acknowledge grant support from The National Health and Medical Research Council, Australia (126402, 209057, 251533, , 396414, 450104, 504700, 504702, 504715, 623204, 940394, 614296,), VicHealth, Cancer Council Victoria, The Prostate Cancer Foundation of Australia, The Whitten Foundation, PricewaterhouseCoopers, and Tattersall’s. EAO, DMK, and EMK acknowledge the Intramural Program of the National Human Genome Research Institute for their support. Genotyping of the OncoArray was funded by the US National Institutes of Health (NIH) [U19 CA 148537 for ELucidating Loci Involved in Prostate cancer SuscEptibility (ELLIPSE) project and X01HG007492 to the Center for Inherited Disease Research (CIDR) under contract number HHSN268201200008I] and by Cancer Research UK grant A8197/A16565. Additional analytic support was provided by NIH NCI U01 CA188392 (PI: Schumacher). Funding for the iCOGS infrastructure came from: the European Community’s Seventh Framework Programme under grant agreement n° 223175 (HEALTH-F2-2009-223175) (COGS), Cancer Research UK (C1287/A10118, C1287/A 10710, C12292/A11174, C1281/A12014, C5047/A8384, C5047/A15007, C5047/A10692, C8197/A16565), the National Institutes of Health (CA128978) and Post-Cancer GWAS initiative (1U19 CA148537, 1U19 CA148065 and 1U19 CA148112 – the GAME-ON initiative), the Department of Defence (W81XWH-10-1-0341), the Canadian Institutes of Health Research (CIHR) for the CIHR Team in Familial Risks of Breast Cancer, Komen Foundation for the Cure, the Breast Cancer Research Foundation, and the Ovarian Cancer Research Fund. The BPC3 was supported by the U.S. National Institutes of Health, National Cancer Institute (cooperative agreements U01-CA98233 to D.J.H., U01-CA98710 to S.M.G., U01-CA98216 toE.R., and U01-CA98758 to B.E.H., and Intramural Research Program of NIH/National Cancer Institute, Division of Cancer Epidemiology and Genetics). CAPS GWAS study was supported by the Swedish Cancer Foundation (grant no 09-0677, 11-484, 12-823), the Cancer Risk Prediction Center (CRisP; www.crispcenter.org), a Linneus Centre (Contract ID 70867902) financed by the Swedish Research Council, Swedish Research Council (grant no K2010-70X-20430-04-3, 2014-2269) PEGASUS was supported by the Intramural Research Program, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health. Kindly send a copy of any publication that results from these data to PRACTICAL@icr.ac.uk Terms of use The nature of the data provided should not allow identification of individual subjects. By downloading these data, you agree not to attempt to identify individual subjects, or repost these data to a third party website without permission." MGI Michigan Genomics Initiative GWAS Hits Schumacher FR et al. 2019 29892016 https://www.ncbi.nlm.nih.gov/pubmed/?term=29892016 377 1.8e-55 0.0888129 0.146 0.651 0.634-0.669 OR 4.44 2.87-6.87 4.44 2.87-6.87 3.3 2.36-4.61 3.3 2.36-4.61 3.02 2.4-3.8 3.02 2.4-3.8 2.72 2.27-3.25 2.72 2.27-3.25 2.65 2.3-3.05 2.65 2.3-3.05 1.8 1.42-2.29 1.34e-06 2.28 1.81-2.88 4.69e-12 4.45 3.57-5.54 1.53e-40 TRUE FALSE FALSE TRUE Male 1190 4417 GRCh37/hg19 P<=5e-08 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000581/ScoringFiles/ phewas/PRSWEB_PHECODE185_Pca-PRACTICAL_P_5e-08_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE185_Pca-PRACTICAL_P_5e-08_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode185-ukbb-saige-hrc-x185-p-5e-08-mgi-20200608 prsweb-phecode185-ukbb-saige-hrc-x185-p-5e-08-mgi-20200608 PRSWEB_PHECODE185_UKBB-SAIGE-HRC-X185_P_5e-08_MGI_20200608 P_5e-08 PRSWEB_PHECODE185_UKBB-SAIGE-HRC-X185_P_5e-08_MGI_20200608 185 Cancer of prostate Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative GWAS Hits UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 42 5.8e-43 0.05481 0.148 0.63 0.612-0.648 OR 3.14 1.99-4.96 3.14 1.99-4.96 3.06 2.17-4.31 3.06 2.17-4.31 2.68 2.12-3.38 2.68 2.12-3.38 2.34 1.95-2.8 2.34 1.95-2.8 2.11 1.83-2.43 2.11 1.83-2.43 1.32 1.05-1.66 0.0192 2.31 1.86-2.87 2.72e-14 3.26 2.65-4.01 9.64e-29 TRUE FALSE FALSE TRUE Male 1190 4417 GRCh37/hg19 P<=5e-08 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000589/ScoringFiles/ phewas/PRSWEB_PHECODE185_UKBB-SAIGE-HRC-X185_P_5e-08_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE185_UKBB-SAIGE-HRC-X185_P_5e-08_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode185-20001-1044-pt-mgi-20200608 prsweb-phecode185-20001-1044-pt-mgi-20200608 PRSWEB_PHECODE185_20001-1044_PT_MGI_20200608 P&T PRSWEB_PHECODE185_20001-1044_PT_MGI_20200608 185 Cancer code, self-reported: prostate cancer Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative P&T UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 78 9e-31 0.0409883 0.15 0.608 0.59-0.628 OR 3.17 1.98-5.06 3.17 1.98-5.06 3.34 2.39-4.65 3.34 2.39-4.65 2.65 2.1-3.35 2.65 2.1-3.35 2.12 1.76-2.55 2.12 1.76-2.55 1.86 1.61-2.14 1.86 1.61-2.14 1.58 1.26-1.97 6.09e-05 2.09 1.69-2.59 9.84e-12 2.84 2.32-3.49 1.46e-23 TRUE FALSE FALSE TRUE Male 1190 4417 GRCh37/hg19 P<=1e-05 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000567/ScoringFiles/ phewas/PRSWEB_PHECODE185_20001-1044_PT_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE185_20001-1044_PT_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode185-c3-prostate-pt-mgi-20200608 prsweb-phecode185-c3-prostate-pt-mgi-20200608 PRSWEB_PHECODE185_C3-PROSTATE_PT_MGI_20200608 P&T PRSWEB_PHECODE185_C3-PROSTATE_PT_MGI_20200608 185 Malignant neoplasm of prostate Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative P&T UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 100 2.3e-45 0.0656138 0.148 0.634 0.617-0.653 OR 2.96 1.85-4.74 2.96 1.85-4.74 3 2.13-4.22 3 2.13-4.22 2.73 2.16-3.44 2.73 2.16-3.44 2.46 2.05-2.94 2.46 2.05-2.94 2.32 2.02-2.68 2.32 2.02-2.68 1.62 1.28-2.04 4.6e-05 2.17 1.74-2.71 9.85e-12 3.7 2.99-4.57 9.18e-34 TRUE FALSE FALSE TRUE Male 1190 4417 GRCh37/hg19 P<=2.51e-06 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000571/ScoringFiles/ phewas/PRSWEB_PHECODE185_C3-PROSTATE_PT_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE185_C3-PROSTATE_PT_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode185-c61-pt-mgi-20200608 prsweb-phecode185-c61-pt-mgi-20200608 PRSWEB_PHECODE185_C61_PT_MGI_20200608 P&T PRSWEB_PHECODE185_C61_PT_MGI_20200608 185 Diagnoses - main ICD10: C61 Malignant neoplasm of prostate Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative P&T UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 47 5e-37 0.0626774 0.149 0.619 0.601-0.637 OR 3.1 1.96-4.92 3.1 1.96-4.92 2.88 2.04-4.06 2.88 2.04-4.06 2.59 2.05-3.27 2.59 2.05-3.27 2.18 1.82-2.62 2.18 1.82-2.62 1.95 1.69-2.24 1.95 1.69-2.24 1.56 1.24-1.95 0.000138 2.24 1.81-2.77 1.63e-13 3.11 2.53-3.83 8.39e-27 TRUE FALSE FALSE TRUE Male 1190 4417 GRCh37/hg19 P<=5e-07 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000575/ScoringFiles/ phewas/PRSWEB_PHECODE185_C61_PT_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE185_C61_PT_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode185-gwas-catalog-r2019-05-03-x185-pt-mgi-20200608 prsweb-phecode185-gwas-catalog-r2019-05-03-x185-pt-mgi-20200608 PRSWEB_PHECODE185_GWAS-Catalog-r2019-05-03-X185_PT_MGI_20200608 P&T PRSWEB_PHECODE185_GWAS-Catalog-r2019-05-03-X185_PT_MGI_20200608 185 Prostate cancer;Prostate cancer (early onset) Binary 157 unique SNPs MGI Michigan Genomics Initiative P&T GWAS Catalog (2019-05-03) 17401363;17401366;17603485;18264096;18264097;18264098;19117981;19767754;21743057;21743467;23104005;23535732;24740154;25939597;27262462;29892016;30410027 https://www.ncbi.nlm.nih.gov/pubmed/?term=17401363+17401366+17603485+18264096+18264097+18264098+19117981+19767754+21743057+21743467+23104005+23535732+24740154+25939597+27262462+29892016+30410027 122 7.2e-53 0.0667357 0.147 0.646 0.627-0.664 OR 3.53 2.26-5.51 3.53 2.26-5.51 3.59 2.58-4.99 3.59 2.58-4.99 2.74 2.17-3.46 2.74 2.17-3.46 2.71 2.27-3.24 2.71 2.27-3.24 2.45 2.13-2.82 2.45 2.13-2.82 1.59 1.25-2.02 0.000136 2.43 1.94-3.05 1.28e-14 4.02 3.25-4.98 3e-37 TRUE FALSE FALSE TRUE Male 1190 4417 GRCh37/hg19 P<=2.51e-07 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000579/ScoringFiles/ phewas/PRSWEB_PHECODE185_GWAS-Catalog-r2019-05-03-X185_PT_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE185_GWAS-Catalog-r2019-05-03-X185_PT_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode185-pca-practical-pt-mgi-20200608 prsweb-phecode185-pca-practical-pt-mgi-20200608 PRSWEB_PHECODE185_Pca-PRACTICAL_PT_MGI_20200608 P&T PRSWEB_PHECODE185_Pca-PRACTICAL_PT_MGI_20200608 185 Prostate cancer Binary "Meta analysis summary data Meta summary association statistics for overall Prostate Cancer, as described in Schumacher, Al Olama, Berndt, et al. 2018 are provided. Acknowledgements When using these data, please cite: Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci. Schumacher, Al Olama, Berndt, et al. Nature Genetics 2018, acknowledge “The PRACTICAL consortium, CRUK, BPC3, CAPS, PEGASUS”, and include the following: The Prostate cancer genome-wide association analyses are supported by the Canadian Institutes of Health Research, European Commission’s Seventh Framework Programme grant agreement n° 223175 (HEALTH-F2-2009-223175), Cancer Research UK Grants C5047/A7357, C1287/A10118, C1287/A16563, C5047/A3354, C5047/A10692, C16913/A6135, and The National Institute of Health (NIH) Cancer Post-Cancer GWAS initiative grant: No. 1 U19 CA 148537-01 (the GAME-ON initiative). We would also like to thank the following for funding support: The Institute of Cancer Research and The Everyman Campaign, The Prostate Cancer Research Foundation, Prostate Research Campaign UK (now Prostate Action), The Orchid Cancer Appeal, The National Cancer Research Network UK, The National Cancer Research Institute (NCRI) UK. We are grateful for support of NIHR funding to the NIHR Biomedical Research Centre at The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust. The Prostate Cancer Program of Cancer Council Victoria also acknowledge grant support from The National Health and Medical Research Council, Australia (126402, 209057, 251533, , 396414, 450104, 504700, 504702, 504715, 623204, 940394, 614296,), VicHealth, Cancer Council Victoria, The Prostate Cancer Foundation of Australia, The Whitten Foundation, PricewaterhouseCoopers, and Tattersall’s. EAO, DMK, and EMK acknowledge the Intramural Program of the National Human Genome Research Institute for their support. Genotyping of the OncoArray was funded by the US National Institutes of Health (NIH) [U19 CA 148537 for ELucidating Loci Involved in Prostate cancer SuscEptibility (ELLIPSE) project and X01HG007492 to the Center for Inherited Disease Research (CIDR) under contract number HHSN268201200008I] and by Cancer Research UK grant A8197/A16565. Additional analytic support was provided by NIH NCI U01 CA188392 (PI: Schumacher). Funding for the iCOGS infrastructure came from: the European Community’s Seventh Framework Programme under grant agreement n° 223175 (HEALTH-F2-2009-223175) (COGS), Cancer Research UK (C1287/A10118, C1287/A 10710, C12292/A11174, C1281/A12014, C5047/A8384, C5047/A15007, C5047/A10692, C8197/A16565), the National Institutes of Health (CA128978) and Post-Cancer GWAS initiative (1U19 CA148537, 1U19 CA148065 and 1U19 CA148112 – the GAME-ON initiative), the Department of Defence (W81XWH-10-1-0341), the Canadian Institutes of Health Research (CIHR) for the CIHR Team in Familial Risks of Breast Cancer, Komen Foundation for the Cure, the Breast Cancer Research Foundation, and the Ovarian Cancer Research Fund. The BPC3 was supported by the U.S. National Institutes of Health, National Cancer Institute (cooperative agreements U01-CA98233 to D.J.H., U01-CA98710 to S.M.G., U01-CA98216 toE.R., and U01-CA98758 to B.E.H., and Intramural Research Program of NIH/National Cancer Institute, Division of Cancer Epidemiology and Genetics). CAPS GWAS study was supported by the Swedish Cancer Foundation (grant no 09-0677, 11-484, 12-823), the Cancer Risk Prediction Center (CRisP; www.crispcenter.org), a Linneus Centre (Contract ID 70867902) financed by the Swedish Research Council, Swedish Research Council (grant no K2010-70X-20430-04-3, 2014-2269) PEGASUS was supported by the Intramural Research Program, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health. Kindly send a copy of any publication that results from these data to PRACTICAL@icr.ac.uk Terms of use The nature of the data provided should not allow identification of individual subjects. By downloading these data, you agree not to attempt to identify individual subjects, or repost these data to a third party website without permission." MGI Michigan Genomics Initiative P&T Schumacher FR et al. 2019 29892016 https://www.ncbi.nlm.nih.gov/pubmed/?term=29892016 1301 1.6e-65 0.0897595 0.145 0.67 0.652-0.688 OR 3.3 2.06-5.29 3.3 2.06-5.29 2.96 2.08-4.2 2.96 2.08-4.2 3.01 2.39-3.78 3.01 2.39-3.78 2.85 2.39-3.4 2.85 2.39-3.4 3.07 2.67-3.53 3.07 2.67-3.53 1.92 1.49-2.46 3.79e-07 2.61 2.05-3.33 1.22e-14 5.6 4.45-7.04 3.14e-49 TRUE FALSE FALSE TRUE Male 1190 4417 GRCh37/hg19 P<=6.31e-05 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000585/ScoringFiles/ phewas/PRSWEB_PHECODE185_Pca-PRACTICAL_PT_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE185_Pca-PRACTICAL_PT_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode185-ukbb-saige-hrc-x185-pt-mgi-20200608 prsweb-phecode185-ukbb-saige-hrc-x185-pt-mgi-20200608 PRSWEB_PHECODE185_UKBB-SAIGE-HRC-X185_PT_MGI_20200608 P&T PRSWEB_PHECODE185_UKBB-SAIGE-HRC-X185_PT_MGI_20200608 185 Cancer of prostate Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative P&T UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 80 5.9e-40 0.0595594 0.149 0.627 0.608-0.645 OR 3.18 2.01-5.02 3.18 2.01-5.02 3.57 2.57-4.95 3.57 2.57-4.95 2.85 2.26-3.58 2.85 2.26-3.58 2.21 1.84-2.66 2.21 1.84-2.66 2.13 1.85-2.45 2.13 1.85-2.45 1.46 1.17-1.84 0.00106 2.09 1.69-2.6 2.26e-11 3.21 2.61-3.94 1.4e-28 TRUE FALSE FALSE TRUE Male 1190 4417 GRCh37/hg19 P<=1.26e-06 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000591/ScoringFiles/ phewas/PRSWEB_PHECODE185_UKBB-SAIGE-HRC-X185_PT_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE185_UKBB-SAIGE-HRC-X185_PT_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode185-20001-1044-prs-cs-mgi-20200608 prsweb-phecode185-20001-1044-prs-cs-mgi-20200608 PRSWEB_PHECODE185_20001-1044_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE185_20001-1044_PRS-CS_MGI_20200608 185 Cancer code, self-reported: prostate cancer Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative PRS-CS UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1111494 4.8e-21 0.0209629 0.152 0.591 0.573-0.609 OR 2.85 1.76-4.62 2.85 1.76-4.62 2.43 1.68-3.5 2.43 1.68-3.5 1.88 1.45-2.43 1.88 1.45-2.43 1.59 1.31-1.95 1.59 1.31-1.95 1.74 1.51-2.01 1.74 1.51-2.01 1.11 0.898-1.37 0.335 1.66 1.36-2.04 8.27e-07 2.17 1.79-2.64 5.76e-15 TRUE FALSE FALSE TRUE Male 1190 4417 GRCh37/hg19 auto https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000566/ScoringFiles/ phewas/PRSWEB_PHECODE185_20001-1044_PRS-CS_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE185_20001-1044_PRS-CS_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode185-c3-prostate-prs-cs-mgi-20200608 prsweb-phecode185-c3-prostate-prs-cs-mgi-20200608 PRSWEB_PHECODE185_C3-PROSTATE_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE185_C3-PROSTATE_PRS-CS_MGI_20200608 185 Malignant neoplasm of prostate Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative PRS-CS UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1111493 2e-36 0.0413552 0.149 0.622 0.604-0.639 OR 2.66 1.63-4.34 2.66 1.63-4.34 2.61 1.82-3.74 2.61 1.82-3.74 2.21 1.72-2.83 2.21 1.72-2.83 2.15 1.79-2.6 2.15 1.79-2.6 2.06 1.79-2.37 2.06 1.79-2.37 1.36 1.09-1.71 0.00687 1.99 1.6-2.46 2.94e-10 2.96 2.42-3.64 1.7e-25 TRUE FALSE FALSE TRUE Male 1190 4417 GRCh37/hg19 auto https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000570/ScoringFiles/ phewas/PRSWEB_PHECODE185_C3-PROSTATE_PRS-CS_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE185_C3-PROSTATE_PRS-CS_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode185-c61-prs-cs-mgi-20200608 prsweb-phecode185-c61-prs-cs-mgi-20200608 PRSWEB_PHECODE185_C61_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE185_C61_PRS-CS_MGI_20200608 185 Diagnoses - main ICD10: C61 Malignant neoplasm of prostate Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative PRS-CS UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1111493 2.3e-31 0.0256089 0.15 0.612 0.593-0.63 OR 2.09 1.24-3.52 2.09 1.24-3.52 2.55 1.79-3.63 2.55 1.79-3.63 2.54 2-3.21 2.54 2-3.21 2.21 1.84-2.66 2.21 1.84-2.66 1.95 1.69-2.25 1.95 1.69-2.25 1.42 1.14-1.77 0.00186 1.87 1.52-2.31 5.48e-09 2.78 2.27-3.4 3.33e-23 TRUE FALSE FALSE TRUE Male 1190 4417 GRCh37/hg19 auto https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000574/ScoringFiles/ phewas/PRSWEB_PHECODE185_C61_PRS-CS_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE185_C61_PRS-CS_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode185-pca-practical-prs-cs-mgi-20200608 prsweb-phecode185-pca-practical-prs-cs-mgi-20200608 PRSWEB_PHECODE185_Pca-PRACTICAL_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE185_Pca-PRACTICAL_PRS-CS_MGI_20200608 185 Prostate cancer Binary "Meta analysis summary data Meta summary association statistics for overall Prostate Cancer, as described in Schumacher, Al Olama, Berndt, et al. 2018 are provided. Acknowledgements When using these data, please cite: Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci. Schumacher, Al Olama, Berndt, et al. Nature Genetics 2018, acknowledge “The PRACTICAL consortium, CRUK, BPC3, CAPS, PEGASUS”, and include the following: The Prostate cancer genome-wide association analyses are supported by the Canadian Institutes of Health Research, European Commission’s Seventh Framework Programme grant agreement n° 223175 (HEALTH-F2-2009-223175), Cancer Research UK Grants C5047/A7357, C1287/A10118, C1287/A16563, C5047/A3354, C5047/A10692, C16913/A6135, and The National Institute of Health (NIH) Cancer Post-Cancer GWAS initiative grant: No. 1 U19 CA 148537-01 (the GAME-ON initiative). We would also like to thank the following for funding support: The Institute of Cancer Research and The Everyman Campaign, The Prostate Cancer Research Foundation, Prostate Research Campaign UK (now Prostate Action), The Orchid Cancer Appeal, The National Cancer Research Network UK, The National Cancer Research Institute (NCRI) UK. We are grateful for support of NIHR funding to the NIHR Biomedical Research Centre at The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust. The Prostate Cancer Program of Cancer Council Victoria also acknowledge grant support from The National Health and Medical Research Council, Australia (126402, 209057, 251533, , 396414, 450104, 504700, 504702, 504715, 623204, 940394, 614296,), VicHealth, Cancer Council Victoria, The Prostate Cancer Foundation of Australia, The Whitten Foundation, PricewaterhouseCoopers, and Tattersall’s. EAO, DMK, and EMK acknowledge the Intramural Program of the National Human Genome Research Institute for their support. Genotyping of the OncoArray was funded by the US National Institutes of Health (NIH) [U19 CA 148537 for ELucidating Loci Involved in Prostate cancer SuscEptibility (ELLIPSE) project and X01HG007492 to the Center for Inherited Disease Research (CIDR) under contract number HHSN268201200008I] and by Cancer Research UK grant A8197/A16565. Additional analytic support was provided by NIH NCI U01 CA188392 (PI: Schumacher). Funding for the iCOGS infrastructure came from: the European Community’s Seventh Framework Programme under grant agreement n° 223175 (HEALTH-F2-2009-223175) (COGS), Cancer Research UK (C1287/A10118, C1287/A 10710, C12292/A11174, C1281/A12014, C5047/A8384, C5047/A15007, C5047/A10692, C8197/A16565), the National Institutes of Health (CA128978) and Post-Cancer GWAS initiative (1U19 CA148537, 1U19 CA148065 and 1U19 CA148112 – the GAME-ON initiative), the Department of Defence (W81XWH-10-1-0341), the Canadian Institutes of Health Research (CIHR) for the CIHR Team in Familial Risks of Breast Cancer, Komen Foundation for the Cure, the Breast Cancer Research Foundation, and the Ovarian Cancer Research Fund. The BPC3 was supported by the U.S. National Institutes of Health, National Cancer Institute (cooperative agreements U01-CA98233 to D.J.H., U01-CA98710 to S.M.G., U01-CA98216 toE.R., and U01-CA98758 to B.E.H., and Intramural Research Program of NIH/National Cancer Institute, Division of Cancer Epidemiology and Genetics). CAPS GWAS study was supported by the Swedish Cancer Foundation (grant no 09-0677, 11-484, 12-823), the Cancer Risk Prediction Center (CRisP; www.crispcenter.org), a Linneus Centre (Contract ID 70867902) financed by the Swedish Research Council, Swedish Research Council (grant no K2010-70X-20430-04-3, 2014-2269) PEGASUS was supported by the Intramural Research Program, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health. Kindly send a copy of any publication that results from these data to PRACTICAL@icr.ac.uk Terms of use The nature of the data provided should not allow identification of individual subjects. By downloading these data, you agree not to attempt to identify individual subjects, or repost these data to a third party website without permission." MGI Michigan Genomics Initiative PRS-CS Schumacher FR et al. 2019 29892016 https://www.ncbi.nlm.nih.gov/pubmed/?term=29892016 1119311 6.9e-67 0.0898146 0.145 0.668 0.651-0.687 OR 3.61 2.28-5.72 3.61 2.28-5.72 3.95 2.86-5.45 3.95 2.86-5.45 3.79 3.04-4.73 3.79 3.04-4.73 3.16 2.65-3.76 3.16 2.65-3.76 2.66 2.31-3.06 2.66 2.31-3.06 2.26 1.74-2.93 1.13e-09 3.53 2.75-4.54 5.68e-23 5.96 4.68-7.58 1.15e-47 TRUE FALSE FALSE TRUE Male 1190 4417 GRCh37/hg19 auto https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000583/ScoringFiles/ phewas/PRSWEB_PHECODE185_Pca-PRACTICAL_PRS-CS_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE185_Pca-PRACTICAL_PRS-CS_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode185-ukbb-saige-hrc-x185-prs-cs-mgi-20200608 prsweb-phecode185-ukbb-saige-hrc-x185-prs-cs-mgi-20200608 PRSWEB_PHECODE185_UKBB-SAIGE-HRC-X185_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE185_UKBB-SAIGE-HRC-X185_PRS-CS_MGI_20200608 185 Cancer of prostate Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative PRS-CS UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1119236 3.8e-32 0.0350197 0.15 0.614 0.595-0.633 OR 2.32 1.42-3.78 2.32 1.42-3.78 2.46 1.72-3.53 2.46 1.72-3.53 2.56 2.02-3.26 2.56 2.02-3.26 2.11 1.75-2.55 2.11 1.75-2.55 1.85 1.61-2.13 1.85 1.61-2.13 1.65 1.32-2.06 1.02e-05 2.1 1.69-2.61 1.65e-11 2.89 2.35-3.56 9.25e-24 TRUE FALSE FALSE TRUE Male 1190 4417 GRCh37/hg19 auto https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000590/ScoringFiles/ phewas/PRSWEB_PHECODE185_UKBB-SAIGE-HRC-X185_PRS-CS_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE185_UKBB-SAIGE-HRC-X185_PRS-CS_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode185-20001-1044-lassosum-mgi-20200608 prsweb-phecode185-20001-1044-lassosum-mgi-20200608 PRSWEB_PHECODE185_20001-1044_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE185_20001-1044_LASSOSUM_MGI_20200608 185 Cancer code, self-reported: prostate cancer Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative lassosum UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1401 3.5e-24 0.0398312 0.151 0.595 0.577-0.614 OR 1.53 0.88-2.66 1.53 0.88-2.66 2.03 1.39-2.97 2.03 1.39-2.97 1.99 1.54-2.55 1.99 1.54-2.55 1.98 1.64-2.39 1.98 1.64-2.39 1.67 1.45-1.93 1.67 1.45-1.93 1.29 1.04-1.61 0.0208 2 1.63-2.45 2.6e-11 2.41 1.97-2.95 1.32e-17 TRUE FALSE FALSE TRUE Male 1190 4417 GRCh37/hg19 s=0.9;Lambda=0.03793 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000568/ScoringFiles/ phewas/PRSWEB_PHECODE185_20001-1044_LASSOSUM_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE185_20001-1044_LASSOSUM_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode185-c3-prostate-lassosum-mgi-20200608 prsweb-phecode185-c3-prostate-lassosum-mgi-20200608 PRSWEB_PHECODE185_C3-PROSTATE_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE185_C3-PROSTATE_LASSOSUM_MGI_20200608 185 Malignant neoplasm of prostate Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative lassosum UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1809 3.2e-33 0.0527929 0.15 0.616 0.597-0.636 OR 4.03 2.59-6.28 4.03 2.59-6.28 2.87 2.03-4.05 2.87 2.03-4.05 2.26 1.77-2.87 2.26 1.77-2.87 1.93 1.6-2.33 1.93 1.6-2.33 1.91 1.65-2.2 1.91 1.65-2.2 1.33 1.06-1.66 0.0134 2.08 1.68-2.57 1.37e-11 2.78 2.26-3.4 8.33e-23 TRUE FALSE FALSE TRUE Male 1190 4417 GRCh37/hg19 s=0.5;Lambda=0.02336 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000572/ScoringFiles/ phewas/PRSWEB_PHECODE185_C3-PROSTATE_LASSOSUM_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE185_C3-PROSTATE_LASSOSUM_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode185-c61-lassosum-mgi-20200608 prsweb-phecode185-c61-lassosum-mgi-20200608 PRSWEB_PHECODE185_C61_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE185_C61_LASSOSUM_MGI_20200608 185 Diagnoses - main ICD10: C61 Malignant neoplasm of prostate Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative lassosum UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 905 1.6e-29 0.0489243 0.151 0.607 0.589-0.627 OR 2.46 1.5-4.01 2.46 1.5-4.01 2.13 1.48-3.07 2.13 1.48-3.07 2.2 1.73-2.81 2.2 1.73-2.81 2 1.66-2.4 2 1.66-2.4 1.85 1.6-2.13 1.85 1.6-2.13 1.49 1.2-1.86 0.00037 2.07 1.67-2.56 2.4e-11 2.77 2.26-3.4 7.85e-23 TRUE FALSE FALSE TRUE Male 1190 4417 GRCh37/hg19 s=0.5;Lambda=0.02976 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000576/ScoringFiles/ phewas/PRSWEB_PHECODE185_C61_LASSOSUM_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE185_C61_LASSOSUM_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode185-pca-practical-lassosum-mgi-20200608 prsweb-phecode185-pca-practical-lassosum-mgi-20200608 PRSWEB_PHECODE185_Pca-PRACTICAL_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE185_Pca-PRACTICAL_LASSOSUM_MGI_20200608 185 Prostate cancer Binary "Meta analysis summary data Meta summary association statistics for overall Prostate Cancer, as described in Schumacher, Al Olama, Berndt, et al. 2018 are provided. Acknowledgements When using these data, please cite: Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci. Schumacher, Al Olama, Berndt, et al. Nature Genetics 2018, acknowledge “The PRACTICAL consortium, CRUK, BPC3, CAPS, PEGASUS”, and include the following: The Prostate cancer genome-wide association analyses are supported by the Canadian Institutes of Health Research, European Commission’s Seventh Framework Programme grant agreement n° 223175 (HEALTH-F2-2009-223175), Cancer Research UK Grants C5047/A7357, C1287/A10118, C1287/A16563, C5047/A3354, C5047/A10692, C16913/A6135, and The National Institute of Health (NIH) Cancer Post-Cancer GWAS initiative grant: No. 1 U19 CA 148537-01 (the GAME-ON initiative). We would also like to thank the following for funding support: The Institute of Cancer Research and The Everyman Campaign, The Prostate Cancer Research Foundation, Prostate Research Campaign UK (now Prostate Action), The Orchid Cancer Appeal, The National Cancer Research Network UK, The National Cancer Research Institute (NCRI) UK. We are grateful for support of NIHR funding to the NIHR Biomedical Research Centre at The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust. The Prostate Cancer Program of Cancer Council Victoria also acknowledge grant support from The National Health and Medical Research Council, Australia (126402, 209057, 251533, , 396414, 450104, 504700, 504702, 504715, 623204, 940394, 614296,), VicHealth, Cancer Council Victoria, The Prostate Cancer Foundation of Australia, The Whitten Foundation, PricewaterhouseCoopers, and Tattersall’s. EAO, DMK, and EMK acknowledge the Intramural Program of the National Human Genome Research Institute for their support. Genotyping of the OncoArray was funded by the US National Institutes of Health (NIH) [U19 CA 148537 for ELucidating Loci Involved in Prostate cancer SuscEptibility (ELLIPSE) project and X01HG007492 to the Center for Inherited Disease Research (CIDR) under contract number HHSN268201200008I] and by Cancer Research UK grant A8197/A16565. Additional analytic support was provided by NIH NCI U01 CA188392 (PI: Schumacher). Funding for the iCOGS infrastructure came from: the European Community’s Seventh Framework Programme under grant agreement n° 223175 (HEALTH-F2-2009-223175) (COGS), Cancer Research UK (C1287/A10118, C1287/A 10710, C12292/A11174, C1281/A12014, C5047/A8384, C5047/A15007, C5047/A10692, C8197/A16565), the National Institutes of Health (CA128978) and Post-Cancer GWAS initiative (1U19 CA148537, 1U19 CA148065 and 1U19 CA148112 – the GAME-ON initiative), the Department of Defence (W81XWH-10-1-0341), the Canadian Institutes of Health Research (CIHR) for the CIHR Team in Familial Risks of Breast Cancer, Komen Foundation for the Cure, the Breast Cancer Research Foundation, and the Ovarian Cancer Research Fund. The BPC3 was supported by the U.S. National Institutes of Health, National Cancer Institute (cooperative agreements U01-CA98233 to D.J.H., U01-CA98710 to S.M.G., U01-CA98216 toE.R., and U01-CA98758 to B.E.H., and Intramural Research Program of NIH/National Cancer Institute, Division of Cancer Epidemiology and Genetics). CAPS GWAS study was supported by the Swedish Cancer Foundation (grant no 09-0677, 11-484, 12-823), the Cancer Risk Prediction Center (CRisP; www.crispcenter.org), a Linneus Centre (Contract ID 70867902) financed by the Swedish Research Council, Swedish Research Council (grant no K2010-70X-20430-04-3, 2014-2269) PEGASUS was supported by the Intramural Research Program, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health. Kindly send a copy of any publication that results from these data to PRACTICAL@icr.ac.uk Terms of use The nature of the data provided should not allow identification of individual subjects. By downloading these data, you agree not to attempt to identify individual subjects, or repost these data to a third party website without permission." MGI Michigan Genomics Initiative lassosum Schumacher FR et al. 2019 29892016 https://www.ncbi.nlm.nih.gov/pubmed/?term=29892016 26418 3.3e-66 0.0919723 0.145 0.665 0.647-0.684 OR 4.92 3.21-7.55 4.92 3.21-7.55 3.98 2.88-5.5 3.98 2.88-5.5 3.26 2.6-4.08 3.26 2.6-4.08 2.98 2.5-3.56 2.98 2.5-3.56 2.78 2.41-3.2 2.78 2.41-3.2 1.94 1.51-2.49 2.37e-07 2.83 2.23-3.6 2.21e-17 5.35 4.25-6.73 1.21e-46 TRUE FALSE FALSE TRUE Male 1190 4417 GRCh37/hg19 s=0.5;Lambda=0.006952 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000587/ScoringFiles/ phewas/PRSWEB_PHECODE185_Pca-PRACTICAL_LASSOSUM_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE185_Pca-PRACTICAL_LASSOSUM_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode185-ukbb-saige-hrc-x185-lassosum-mgi-20200608 prsweb-phecode185-ukbb-saige-hrc-x185-lassosum-mgi-20200608 PRSWEB_PHECODE185_UKBB-SAIGE-HRC-X185_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE185_UKBB-SAIGE-HRC-X185_LASSOSUM_MGI_20200608 185 Cancer of prostate Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative lassosum UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1334 2.5e-33 0.0503 0.15 0.616 0.598-0.635 OR 2.55 1.55-4.2 2.55 1.55-4.2 2.33 1.6-3.38 2.33 1.6-3.38 2.28 1.79-2.9 2.28 1.79-2.9 2 1.66-2.42 2 1.66-2.42 1.88 1.63-2.17 1.88 1.63-2.17 1.53 1.22-1.92 0.00025 2.3 1.85-2.84 2.29e-14 3.01 2.44-3.71 2.89e-25 TRUE FALSE FALSE TRUE Male 1190 4417 GRCh37/hg19 s=0.5;Lambda=0.02336 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000592/ScoringFiles/ phewas/PRSWEB_PHECODE185_UKBB-SAIGE-HRC-X185_LASSOSUM_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE185_UKBB-SAIGE-HRC-X185_LASSOSUM_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode185-gwas-catalog-r2019-05-03-x185-p-5e-05-ukb-20200608 prsweb-phecode185-gwas-catalog-r2019-05-03-x185-p-5e-05-ukb-20200608 PRSWEB_PHECODE185_GWAS-Catalog-r2019-05-03-X185_P_5e-05_UKB_20200608 P_5e-05 PRSWEB_PHECODE185_GWAS-Catalog-r2019-05-03-X185_P_5e-05_UKB_20200608 185 Prostate cancer;Prostate cancer (early onset) Binary 157 unique SNPs UKB UK Biobank Fixed threshold (5e-05) GWAS Catalog (2019-05-03) 17401363;17401366;17603485;18264096;18264097;18264098;19117981;19767754;21743057;21743467;23104005;23535732;24740154;25939597;27262462;29892016;30410027 https://www.ncbi.nlm.nih.gov/pubmed/?term=17401363+17401366+17603485+18264096+18264097+18264098+19117981+19767754+21743057+21743467+23104005+23535732+24740154+25939597+27262462+29892016+30410027 124 6.1e-181 0.0571946 0.0813 0.65 0.64-0.661 OR 3.8 3.05-4.75 3.8 3.05-4.75 3.29 2.78-3.89 3.29 2.78-3.89 3.15 2.81-3.54 3.15 2.81-3.54 2.79 2.55-3.06 2.79 2.55-3.06 2.6 2.41-2.81 2.6 2.41-2.81 1.41 1.23-1.62 1.25e-06 2.11 1.86-2.41 1.48e-29 3.93 3.48-4.43 1.32e-109 TRUE FALSE FALSE FALSE Male 3012 29652 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode185-pca-practical-p-5e-05-ukb-20200608 prsweb-phecode185-pca-practical-p-5e-05-ukb-20200608 PRSWEB_PHECODE185_Pca-PRACTICAL_P_5e-05_UKB_20200608 P_5e-05 PRSWEB_PHECODE185_Pca-PRACTICAL_P_5e-05_UKB_20200608 185 Prostate cancer Binary "Meta analysis summary data Meta summary association statistics for overall Prostate Cancer, as described in Schumacher, Al Olama, Berndt, et al. 2018 are provided. Acknowledgements When using these data, please cite: Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci. Schumacher, Al Olama, Berndt, et al. Nature Genetics 2018, acknowledge “The PRACTICAL consortium, CRUK, BPC3, CAPS, PEGASUS”, and include the following: The Prostate cancer genome-wide association analyses are supported by the Canadian Institutes of Health Research, European Commission’s Seventh Framework Programme grant agreement n° 223175 (HEALTH-F2-2009-223175), Cancer Research UK Grants C5047/A7357, C1287/A10118, C1287/A16563, C5047/A3354, C5047/A10692, C16913/A6135, and The National Institute of Health (NIH) Cancer Post-Cancer GWAS initiative grant: No. 1 U19 CA 148537-01 (the GAME-ON initiative). We would also like to thank the following for funding support: The Institute of Cancer Research and The Everyman Campaign, The Prostate Cancer Research Foundation, Prostate Research Campaign UK (now Prostate Action), The Orchid Cancer Appeal, The National Cancer Research Network UK, The National Cancer Research Institute (NCRI) UK. We are grateful for support of NIHR funding to the NIHR Biomedical Research Centre at The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust. The Prostate Cancer Program of Cancer Council Victoria also acknowledge grant support from The National Health and Medical Research Council, Australia (126402, 209057, 251533, , 396414, 450104, 504700, 504702, 504715, 623204, 940394, 614296,), VicHealth, Cancer Council Victoria, The Prostate Cancer Foundation of Australia, The Whitten Foundation, PricewaterhouseCoopers, and Tattersall’s. EAO, DMK, and EMK acknowledge the Intramural Program of the National Human Genome Research Institute for their support. Genotyping of the OncoArray was funded by the US National Institutes of Health (NIH) [U19 CA 148537 for ELucidating Loci Involved in Prostate cancer SuscEptibility (ELLIPSE) project and X01HG007492 to the Center for Inherited Disease Research (CIDR) under contract number HHSN268201200008I] and by Cancer Research UK grant A8197/A16565. Additional analytic support was provided by NIH NCI U01 CA188392 (PI: Schumacher). Funding for the iCOGS infrastructure came from: the European Community’s Seventh Framework Programme under grant agreement n° 223175 (HEALTH-F2-2009-223175) (COGS), Cancer Research UK (C1287/A10118, C1287/A 10710, C12292/A11174, C1281/A12014, C5047/A8384, C5047/A15007, C5047/A10692, C8197/A16565), the National Institutes of Health (CA128978) and Post-Cancer GWAS initiative (1U19 CA148537, 1U19 CA148065 and 1U19 CA148112 – the GAME-ON initiative), the Department of Defence (W81XWH-10-1-0341), the Canadian Institutes of Health Research (CIHR) for the CIHR Team in Familial Risks of Breast Cancer, Komen Foundation for the Cure, the Breast Cancer Research Foundation, and the Ovarian Cancer Research Fund. The BPC3 was supported by the U.S. National Institutes of Health, National Cancer Institute (cooperative agreements U01-CA98233 to D.J.H., U01-CA98710 to S.M.G., U01-CA98216 toE.R., and U01-CA98758 to B.E.H., and Intramural Research Program of NIH/National Cancer Institute, Division of Cancer Epidemiology and Genetics). CAPS GWAS study was supported by the Swedish Cancer Foundation (grant no 09-0677, 11-484, 12-823), the Cancer Risk Prediction Center (CRisP; www.crispcenter.org), a Linneus Centre (Contract ID 70867902) financed by the Swedish Research Council, Swedish Research Council (grant no K2010-70X-20430-04-3, 2014-2269) PEGASUS was supported by the Intramural Research Program, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health. Kindly send a copy of any publication that results from these data to PRACTICAL@icr.ac.uk Terms of use The nature of the data provided should not allow identification of individual subjects. By downloading these data, you agree not to attempt to identify individual subjects, or repost these data to a third party website without permission." UKB UK Biobank Fixed threshold (5e-05) Schumacher FR et al. 2019 29892016 https://www.ncbi.nlm.nih.gov/pubmed/?term=29892016 1223 2.9e-263 0.0792795 0.0799 0.688 0.678-0.698 OR 5.51 4.52-6.71 5.51 4.52-6.71 4.72 4.06-5.48 4.72 4.06-5.48 4.05 3.64-4.51 4.05 3.64-4.51 3.63 3.33-3.97 3.63 3.33-3.97 3.12 2.89-3.37 3.12 2.89-3.37 1.79 1.54-2.09 1.19e-13 2.84 2.46-3.28 1e-45 5.86 5.12-6.7 8.96e-146 TRUE FALSE FALSE FALSE Male 3012 29652 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode185-gwas-catalog-r2019-05-03-x185-p-5e-06-ukb-20200608 prsweb-phecode185-gwas-catalog-r2019-05-03-x185-p-5e-06-ukb-20200608 PRSWEB_PHECODE185_GWAS-Catalog-r2019-05-03-X185_P_5e-06_UKB_20200608 P_5e-06 PRSWEB_PHECODE185_GWAS-Catalog-r2019-05-03-X185_P_5e-06_UKB_20200608 185 Prostate cancer;Prostate cancer (early onset) Binary 157 unique SNPs UKB UK Biobank Fixed threshold (5e-06) GWAS Catalog (2019-05-03) 17401363;17401366;17603485;18264096;18264097;18264098;19117981;19767754;21743057;21743467;23104005;23535732;24740154;25939597;27262462;29892016;30410027 https://www.ncbi.nlm.nih.gov/pubmed/?term=17401363+17401366+17603485+18264096+18264097+18264098+19117981+19767754+21743057+21743467+23104005+23535732+24740154+25939597+27262462+29892016+30410027 124 6.1e-181 0.0571946 0.0813 0.65 0.64-0.661 OR 3.8 3.05-4.75 3.8 3.05-4.75 3.29 2.78-3.89 3.29 2.78-3.89 3.15 2.81-3.54 3.15 2.81-3.54 2.79 2.55-3.06 2.79 2.55-3.06 2.6 2.41-2.81 2.6 2.41-2.81 1.41 1.23-1.62 1.25e-06 2.11 1.86-2.41 1.48e-29 3.93 3.48-4.43 1.32e-109 TRUE FALSE FALSE FALSE Male 3012 29652 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode185-pca-practical-p-5e-06-ukb-20200608 prsweb-phecode185-pca-practical-p-5e-06-ukb-20200608 PRSWEB_PHECODE185_Pca-PRACTICAL_P_5e-06_UKB_20200608 P_5e-06 PRSWEB_PHECODE185_Pca-PRACTICAL_P_5e-06_UKB_20200608 185 Prostate cancer Binary "Meta analysis summary data Meta summary association statistics for overall Prostate Cancer, as described in Schumacher, Al Olama, Berndt, et al. 2018 are provided. Acknowledgements When using these data, please cite: Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci. Schumacher, Al Olama, Berndt, et al. Nature Genetics 2018, acknowledge “The PRACTICAL consortium, CRUK, BPC3, CAPS, PEGASUS”, and include the following: The Prostate cancer genome-wide association analyses are supported by the Canadian Institutes of Health Research, European Commission’s Seventh Framework Programme grant agreement n° 223175 (HEALTH-F2-2009-223175), Cancer Research UK Grants C5047/A7357, C1287/A10118, C1287/A16563, C5047/A3354, C5047/A10692, C16913/A6135, and The National Institute of Health (NIH) Cancer Post-Cancer GWAS initiative grant: No. 1 U19 CA 148537-01 (the GAME-ON initiative). We would also like to thank the following for funding support: The Institute of Cancer Research and The Everyman Campaign, The Prostate Cancer Research Foundation, Prostate Research Campaign UK (now Prostate Action), The Orchid Cancer Appeal, The National Cancer Research Network UK, The National Cancer Research Institute (NCRI) UK. We are grateful for support of NIHR funding to the NIHR Biomedical Research Centre at The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust. The Prostate Cancer Program of Cancer Council Victoria also acknowledge grant support from The National Health and Medical Research Council, Australia (126402, 209057, 251533, , 396414, 450104, 504700, 504702, 504715, 623204, 940394, 614296,), VicHealth, Cancer Council Victoria, The Prostate Cancer Foundation of Australia, The Whitten Foundation, PricewaterhouseCoopers, and Tattersall’s. EAO, DMK, and EMK acknowledge the Intramural Program of the National Human Genome Research Institute for their support. Genotyping of the OncoArray was funded by the US National Institutes of Health (NIH) [U19 CA 148537 for ELucidating Loci Involved in Prostate cancer SuscEptibility (ELLIPSE) project and X01HG007492 to the Center for Inherited Disease Research (CIDR) under contract number HHSN268201200008I] and by Cancer Research UK grant A8197/A16565. Additional analytic support was provided by NIH NCI U01 CA188392 (PI: Schumacher). Funding for the iCOGS infrastructure came from: the European Community’s Seventh Framework Programme under grant agreement n° 223175 (HEALTH-F2-2009-223175) (COGS), Cancer Research UK (C1287/A10118, C1287/A 10710, C12292/A11174, C1281/A12014, C5047/A8384, C5047/A15007, C5047/A10692, C8197/A16565), the National Institutes of Health (CA128978) and Post-Cancer GWAS initiative (1U19 CA148537, 1U19 CA148065 and 1U19 CA148112 – the GAME-ON initiative), the Department of Defence (W81XWH-10-1-0341), the Canadian Institutes of Health Research (CIHR) for the CIHR Team in Familial Risks of Breast Cancer, Komen Foundation for the Cure, the Breast Cancer Research Foundation, and the Ovarian Cancer Research Fund. The BPC3 was supported by the U.S. National Institutes of Health, National Cancer Institute (cooperative agreements U01-CA98233 to D.J.H., U01-CA98710 to S.M.G., U01-CA98216 toE.R., and U01-CA98758 to B.E.H., and Intramural Research Program of NIH/National Cancer Institute, Division of Cancer Epidemiology and Genetics). CAPS GWAS study was supported by the Swedish Cancer Foundation (grant no 09-0677, 11-484, 12-823), the Cancer Risk Prediction Center (CRisP; www.crispcenter.org), a Linneus Centre (Contract ID 70867902) financed by the Swedish Research Council, Swedish Research Council (grant no K2010-70X-20430-04-3, 2014-2269) PEGASUS was supported by the Intramural Research Program, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health. Kindly send a copy of any publication that results from these data to PRACTICAL@icr.ac.uk Terms of use The nature of the data provided should not allow identification of individual subjects. By downloading these data, you agree not to attempt to identify individual subjects, or repost these data to a third party website without permission." UKB UK Biobank Fixed threshold (5e-06) Schumacher FR et al. 2019 29892016 https://www.ncbi.nlm.nih.gov/pubmed/?term=29892016 691 3.1e-257 0.0772015 0.0801 0.686 0.676-0.696 OR 5.01 4.1-6.14 5.01 4.1-6.14 4.22 3.61-4.92 4.22 3.61-4.92 3.92 3.52-4.37 3.92 3.52-4.37 3.59 3.28-3.92 3.59 3.28-3.92 3.05 2.83-3.29 3.05 2.83-3.29 1.58 1.35-1.84 4.78e-09 2.73 2.37-3.14 8.42e-45 5.39 4.73-6.14 4.18e-140 TRUE FALSE FALSE FALSE Male 3012 29652 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode185-gwas-catalog-r2019-05-03-x185-p-5e-07-ukb-20200608 prsweb-phecode185-gwas-catalog-r2019-05-03-x185-p-5e-07-ukb-20200608 PRSWEB_PHECODE185_GWAS-Catalog-r2019-05-03-X185_P_5e-07_UKB_20200608 P_5e-07 PRSWEB_PHECODE185_GWAS-Catalog-r2019-05-03-X185_P_5e-07_UKB_20200608 185 Prostate cancer;Prostate cancer (early onset) Binary 157 unique SNPs UKB UK Biobank Fixed threshold (5e-07) GWAS Catalog (2019-05-03) 17401363;17401366;17603485;18264096;18264097;18264098;19117981;19767754;21743057;21743467;23104005;23535732;24740154;25939597;27262462;29892016;30410027 https://www.ncbi.nlm.nih.gov/pubmed/?term=17401363+17401366+17603485+18264096+18264097+18264098+19117981+19767754+21743057+21743467+23104005+23535732+24740154+25939597+27262462+29892016+30410027 123 7.5e-181 0.0571079 0.0813 0.65 0.64-0.66 OR 3.77 3.02-4.7 3.77 3.02-4.7 3.36 2.84-3.97 3.36 2.84-3.97 3.2 2.86-3.59 3.2 2.86-3.59 2.82 2.57-3.09 2.82 2.57-3.09 2.55 2.36-2.75 2.55 2.36-2.75 1.42 1.24-1.64 7.39e-07 2.17 1.91-2.47 1.23e-31 3.91 3.46-4.41 4.21e-108 TRUE FALSE FALSE FALSE Male 3012 29652 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode185-pca-practical-p-5e-07-ukb-20200608 prsweb-phecode185-pca-practical-p-5e-07-ukb-20200608 PRSWEB_PHECODE185_Pca-PRACTICAL_P_5e-07_UKB_20200608 P_5e-07 PRSWEB_PHECODE185_Pca-PRACTICAL_P_5e-07_UKB_20200608 185 Prostate cancer Binary "Meta analysis summary data Meta summary association statistics for overall Prostate Cancer, as described in Schumacher, Al Olama, Berndt, et al. 2018 are provided. Acknowledgements When using these data, please cite: Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci. Schumacher, Al Olama, Berndt, et al. Nature Genetics 2018, acknowledge “The PRACTICAL consortium, CRUK, BPC3, CAPS, PEGASUS”, and include the following: The Prostate cancer genome-wide association analyses are supported by the Canadian Institutes of Health Research, European Commission’s Seventh Framework Programme grant agreement n° 223175 (HEALTH-F2-2009-223175), Cancer Research UK Grants C5047/A7357, C1287/A10118, C1287/A16563, C5047/A3354, C5047/A10692, C16913/A6135, and The National Institute of Health (NIH) Cancer Post-Cancer GWAS initiative grant: No. 1 U19 CA 148537-01 (the GAME-ON initiative). We would also like to thank the following for funding support: The Institute of Cancer Research and The Everyman Campaign, The Prostate Cancer Research Foundation, Prostate Research Campaign UK (now Prostate Action), The Orchid Cancer Appeal, The National Cancer Research Network UK, The National Cancer Research Institute (NCRI) UK. We are grateful for support of NIHR funding to the NIHR Biomedical Research Centre at The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust. The Prostate Cancer Program of Cancer Council Victoria also acknowledge grant support from The National Health and Medical Research Council, Australia (126402, 209057, 251533, , 396414, 450104, 504700, 504702, 504715, 623204, 940394, 614296,), VicHealth, Cancer Council Victoria, The Prostate Cancer Foundation of Australia, The Whitten Foundation, PricewaterhouseCoopers, and Tattersall’s. EAO, DMK, and EMK acknowledge the Intramural Program of the National Human Genome Research Institute for their support. Genotyping of the OncoArray was funded by the US National Institutes of Health (NIH) [U19 CA 148537 for ELucidating Loci Involved in Prostate cancer SuscEptibility (ELLIPSE) project and X01HG007492 to the Center for Inherited Disease Research (CIDR) under contract number HHSN268201200008I] and by Cancer Research UK grant A8197/A16565. Additional analytic support was provided by NIH NCI U01 CA188392 (PI: Schumacher). Funding for the iCOGS infrastructure came from: the European Community’s Seventh Framework Programme under grant agreement n° 223175 (HEALTH-F2-2009-223175) (COGS), Cancer Research UK (C1287/A10118, C1287/A 10710, C12292/A11174, C1281/A12014, C5047/A8384, C5047/A15007, C5047/A10692, C8197/A16565), the National Institutes of Health (CA128978) and Post-Cancer GWAS initiative (1U19 CA148537, 1U19 CA148065 and 1U19 CA148112 – the GAME-ON initiative), the Department of Defence (W81XWH-10-1-0341), the Canadian Institutes of Health Research (CIHR) for the CIHR Team in Familial Risks of Breast Cancer, Komen Foundation for the Cure, the Breast Cancer Research Foundation, and the Ovarian Cancer Research Fund. The BPC3 was supported by the U.S. National Institutes of Health, National Cancer Institute (cooperative agreements U01-CA98233 to D.J.H., U01-CA98710 to S.M.G., U01-CA98216 toE.R., and U01-CA98758 to B.E.H., and Intramural Research Program of NIH/National Cancer Institute, Division of Cancer Epidemiology and Genetics). CAPS GWAS study was supported by the Swedish Cancer Foundation (grant no 09-0677, 11-484, 12-823), the Cancer Risk Prediction Center (CRisP; www.crispcenter.org), a Linneus Centre (Contract ID 70867902) financed by the Swedish Research Council, Swedish Research Council (grant no K2010-70X-20430-04-3, 2014-2269) PEGASUS was supported by the Intramural Research Program, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health. Kindly send a copy of any publication that results from these data to PRACTICAL@icr.ac.uk Terms of use The nature of the data provided should not allow identification of individual subjects. By downloading these data, you agree not to attempt to identify individual subjects, or repost these data to a third party website without permission." UKB UK Biobank Fixed threshold (5e-07) Schumacher FR et al. 2019 29892016 https://www.ncbi.nlm.nih.gov/pubmed/?term=29892016 492 5.8e-250 0.0759608 0.0802 0.683 0.674-0.693 OR 4.81 3.92-5.91 4.81 3.92-5.91 4.37 3.75-5.1 4.37 3.75-5.1 3.81 3.42-4.25 3.81 3.42-4.25 3.43 3.14-3.75 3.43 3.14-3.75 3.05 2.82-3.29 3.05 2.82-3.29 1.6 1.37-1.86 1.13e-09 2.6 2.26-2.98 5.43e-41 5.27 4.63-6 1.1e-138 TRUE FALSE FALSE FALSE Male 3012 29652 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode185-gwas-catalog-r2019-05-03-x185-p-5e-09-ukb-20200608 prsweb-phecode185-gwas-catalog-r2019-05-03-x185-p-5e-09-ukb-20200608 PRSWEB_PHECODE185_GWAS-Catalog-r2019-05-03-X185_P_5e-09_UKB_20200608 P_5e-09 PRSWEB_PHECODE185_GWAS-Catalog-r2019-05-03-X185_P_5e-09_UKB_20200608 185 Prostate cancer;Prostate cancer (early onset) Binary 157 unique SNPs UKB UK Biobank Fixed threshold (5e-09) GWAS Catalog (2019-05-03) 17401363;17401366;17603485;18264096;18264097;18264098;19117981;19767754;21743057;21743467;23104005;23535732;24740154;25939597;27262462;29892016;30410027 https://www.ncbi.nlm.nih.gov/pubmed/?term=17401363+17401366+17603485+18264096+18264097+18264098+19117981+19767754+21743057+21743467+23104005+23535732+24740154+25939597+27262462+29892016+30410027 86 1e-178 0.0578342 0.0813 0.649 0.638-0.659 OR 4.3 3.48-5.32 4.3 3.48-5.32 3.45 2.93-4.07 3.45 2.93-4.07 3.17 2.83-3.55 3.17 2.83-3.55 2.73 2.49-2.99 2.73 2.49-2.99 2.57 2.38-2.77 2.57 2.38-2.77 1.51 1.31-1.73 7e-09 2.13 1.87-2.43 7.35e-30 3.96 3.51-4.47 2.48e-109 TRUE FALSE FALSE FALSE Male 3012 29652 GRCh37/hg19 P<=5e-09 2020-06-08 prsweb-phecode185-pca-practical-p-5e-09-ukb-20200608 prsweb-phecode185-pca-practical-p-5e-09-ukb-20200608 PRSWEB_PHECODE185_Pca-PRACTICAL_P_5e-09_UKB_20200608 P_5e-09 PRSWEB_PHECODE185_Pca-PRACTICAL_P_5e-09_UKB_20200608 185 Prostate cancer Binary "Meta analysis summary data Meta summary association statistics for overall Prostate Cancer, as described in Schumacher, Al Olama, Berndt, et al. 2018 are provided. Acknowledgements When using these data, please cite: Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci. Schumacher, Al Olama, Berndt, et al. Nature Genetics 2018, acknowledge “The PRACTICAL consortium, CRUK, BPC3, CAPS, PEGASUS”, and include the following: The Prostate cancer genome-wide association analyses are supported by the Canadian Institutes of Health Research, European Commission’s Seventh Framework Programme grant agreement n° 223175 (HEALTH-F2-2009-223175), Cancer Research UK Grants C5047/A7357, C1287/A10118, C1287/A16563, C5047/A3354, C5047/A10692, C16913/A6135, and The National Institute of Health (NIH) Cancer Post-Cancer GWAS initiative grant: No. 1 U19 CA 148537-01 (the GAME-ON initiative). We would also like to thank the following for funding support: The Institute of Cancer Research and The Everyman Campaign, The Prostate Cancer Research Foundation, Prostate Research Campaign UK (now Prostate Action), The Orchid Cancer Appeal, The National Cancer Research Network UK, The National Cancer Research Institute (NCRI) UK. We are grateful for support of NIHR funding to the NIHR Biomedical Research Centre at The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust. The Prostate Cancer Program of Cancer Council Victoria also acknowledge grant support from The National Health and Medical Research Council, Australia (126402, 209057, 251533, , 396414, 450104, 504700, 504702, 504715, 623204, 940394, 614296,), VicHealth, Cancer Council Victoria, The Prostate Cancer Foundation of Australia, The Whitten Foundation, PricewaterhouseCoopers, and Tattersall’s. EAO, DMK, and EMK acknowledge the Intramural Program of the National Human Genome Research Institute for their support. Genotyping of the OncoArray was funded by the US National Institutes of Health (NIH) [U19 CA 148537 for ELucidating Loci Involved in Prostate cancer SuscEptibility (ELLIPSE) project and X01HG007492 to the Center for Inherited Disease Research (CIDR) under contract number HHSN268201200008I] and by Cancer Research UK grant A8197/A16565. Additional analytic support was provided by NIH NCI U01 CA188392 (PI: Schumacher). Funding for the iCOGS infrastructure came from: the European Community’s Seventh Framework Programme under grant agreement n° 223175 (HEALTH-F2-2009-223175) (COGS), Cancer Research UK (C1287/A10118, C1287/A 10710, C12292/A11174, C1281/A12014, C5047/A8384, C5047/A15007, C5047/A10692, C8197/A16565), the National Institutes of Health (CA128978) and Post-Cancer GWAS initiative (1U19 CA148537, 1U19 CA148065 and 1U19 CA148112 – the GAME-ON initiative), the Department of Defence (W81XWH-10-1-0341), the Canadian Institutes of Health Research (CIHR) for the CIHR Team in Familial Risks of Breast Cancer, Komen Foundation for the Cure, the Breast Cancer Research Foundation, and the Ovarian Cancer Research Fund. The BPC3 was supported by the U.S. National Institutes of Health, National Cancer Institute (cooperative agreements U01-CA98233 to D.J.H., U01-CA98710 to S.M.G., U01-CA98216 toE.R., and U01-CA98758 to B.E.H., and Intramural Research Program of NIH/National Cancer Institute, Division of Cancer Epidemiology and Genetics). CAPS GWAS study was supported by the Swedish Cancer Foundation (grant no 09-0677, 11-484, 12-823), the Cancer Risk Prediction Center (CRisP; www.crispcenter.org), a Linneus Centre (Contract ID 70867902) financed by the Swedish Research Council, Swedish Research Council (grant no K2010-70X-20430-04-3, 2014-2269) PEGASUS was supported by the Intramural Research Program, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health. Kindly send a copy of any publication that results from these data to PRACTICAL@icr.ac.uk Terms of use The nature of the data provided should not allow identification of individual subjects. By downloading these data, you agree not to attempt to identify individual subjects, or repost these data to a third party website without permission." UKB UK Biobank Fixed threshold (5e-09) Schumacher FR et al. 2019 29892016 https://www.ncbi.nlm.nih.gov/pubmed/?term=29892016 293 2.2e-239 0.0711127 0.0804 0.678 0.668-0.688 OR 4.51 3.66-5.56 4.51 3.66-5.56 4.21 3.6-4.92 4.21 3.6-4.92 3.64 3.26-4.07 3.64 3.26-4.07 3.36 3.08-3.67 3.36 3.08-3.67 3.06 2.84-3.3 3.06 2.84-3.3 1.62 1.4-1.88 1.87e-10 2.42 2.11-2.78 1.1e-35 5.14 4.52-5.84 1.62e-137 TRUE FALSE FALSE FALSE Male 3012 29652 GRCh37/hg19 P<=5e-09 2020-06-08 prsweb-phecode185-gwas-catalog-r2019-05-03-x185-p-5e-08-ukb-20200608 prsweb-phecode185-gwas-catalog-r2019-05-03-x185-p-5e-08-ukb-20200608 PRSWEB_PHECODE185_GWAS-Catalog-r2019-05-03-X185_P_5e-08_UKB_20200608 P_5e-08 PRSWEB_PHECODE185_GWAS-Catalog-r2019-05-03-X185_P_5e-08_UKB_20200608 185 Prostate cancer;Prostate cancer (early onset) Binary 157 unique SNPs UKB UK Biobank GWAS Hits GWAS Catalog (2019-05-03) 17401363;17401366;17603485;18264096;18264097;18264098;19117981;19767754;21743057;21743467;23104005;23535732;24740154;25939597;27262462;29892016;30410027 https://www.ncbi.nlm.nih.gov/pubmed/?term=17401363+17401366+17603485+18264096+18264097+18264098+19117981+19767754+21743057+21743467+23104005+23535732+24740154+25939597+27262462+29892016+30410027 117 5.5e-185 0.0584744 0.0813 0.653 0.642-0.662 OR 4.31 3.48-5.33 4.31 3.48-5.33 3.81 3.25-4.47 3.81 3.25-4.47 3.14 2.8-3.52 3.14 2.8-3.52 2.88 2.63-3.16 2.88 2.63-3.16 2.61 2.42-2.82 2.61 2.42-2.82 1.65 1.43-1.9 3.66e-12 2.28 1.99-2.6 1.55e-33 4.28 3.78-4.85 5.53e-116 TRUE FALSE FALSE TRUE Male 3012 29652 GRCh37/hg19 P<=5e-08 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000578/ScoringFiles/ phewas/PRSWEB_PHECODE185_GWAS-Catalog-r2019-05-03-X185_P_5e-08_UKB_20200608/all.tsv phewas/PRSWEB_PHECODE185_GWAS-Catalog-r2019-05-03-X185_P_5e-08_UKB_20200608/exclusion.tsv 2020-06-08 prsweb-phecode185-pca-practical-p-5e-08-ukb-20200608 prsweb-phecode185-pca-practical-p-5e-08-ukb-20200608 PRSWEB_PHECODE185_Pca-PRACTICAL_P_5e-08_UKB_20200608 P_5e-08 PRSWEB_PHECODE185_Pca-PRACTICAL_P_5e-08_UKB_20200608 185 Prostate cancer Binary "Meta analysis summary data Meta summary association statistics for overall Prostate Cancer, as described in Schumacher, Al Olama, Berndt, et al. 2018 are provided. Acknowledgements When using these data, please cite: Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci. Schumacher, Al Olama, Berndt, et al. Nature Genetics 2018, acknowledge “The PRACTICAL consortium, CRUK, BPC3, CAPS, PEGASUS”, and include the following: The Prostate cancer genome-wide association analyses are supported by the Canadian Institutes of Health Research, European Commission’s Seventh Framework Programme grant agreement n° 223175 (HEALTH-F2-2009-223175), Cancer Research UK Grants C5047/A7357, C1287/A10118, C1287/A16563, C5047/A3354, C5047/A10692, C16913/A6135, and The National Institute of Health (NIH) Cancer Post-Cancer GWAS initiative grant: No. 1 U19 CA 148537-01 (the GAME-ON initiative). We would also like to thank the following for funding support: The Institute of Cancer Research and The Everyman Campaign, The Prostate Cancer Research Foundation, Prostate Research Campaign UK (now Prostate Action), The Orchid Cancer Appeal, The National Cancer Research Network UK, The National Cancer Research Institute (NCRI) UK. We are grateful for support of NIHR funding to the NIHR Biomedical Research Centre at The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust. The Prostate Cancer Program of Cancer Council Victoria also acknowledge grant support from The National Health and Medical Research Council, Australia (126402, 209057, 251533, , 396414, 450104, 504700, 504702, 504715, 623204, 940394, 614296,), VicHealth, Cancer Council Victoria, The Prostate Cancer Foundation of Australia, The Whitten Foundation, PricewaterhouseCoopers, and Tattersall’s. EAO, DMK, and EMK acknowledge the Intramural Program of the National Human Genome Research Institute for their support. Genotyping of the OncoArray was funded by the US National Institutes of Health (NIH) [U19 CA 148537 for ELucidating Loci Involved in Prostate cancer SuscEptibility (ELLIPSE) project and X01HG007492 to the Center for Inherited Disease Research (CIDR) under contract number HHSN268201200008I] and by Cancer Research UK grant A8197/A16565. Additional analytic support was provided by NIH NCI U01 CA188392 (PI: Schumacher). Funding for the iCOGS infrastructure came from: the European Community’s Seventh Framework Programme under grant agreement n° 223175 (HEALTH-F2-2009-223175) (COGS), Cancer Research UK (C1287/A10118, C1287/A 10710, C12292/A11174, C1281/A12014, C5047/A8384, C5047/A15007, C5047/A10692, C8197/A16565), the National Institutes of Health (CA128978) and Post-Cancer GWAS initiative (1U19 CA148537, 1U19 CA148065 and 1U19 CA148112 – the GAME-ON initiative), the Department of Defence (W81XWH-10-1-0341), the Canadian Institutes of Health Research (CIHR) for the CIHR Team in Familial Risks of Breast Cancer, Komen Foundation for the Cure, the Breast Cancer Research Foundation, and the Ovarian Cancer Research Fund. The BPC3 was supported by the U.S. National Institutes of Health, National Cancer Institute (cooperative agreements U01-CA98233 to D.J.H., U01-CA98710 to S.M.G., U01-CA98216 toE.R., and U01-CA98758 to B.E.H., and Intramural Research Program of NIH/National Cancer Institute, Division of Cancer Epidemiology and Genetics). CAPS GWAS study was supported by the Swedish Cancer Foundation (grant no 09-0677, 11-484, 12-823), the Cancer Risk Prediction Center (CRisP; www.crispcenter.org), a Linneus Centre (Contract ID 70867902) financed by the Swedish Research Council, Swedish Research Council (grant no K2010-70X-20430-04-3, 2014-2269) PEGASUS was supported by the Intramural Research Program, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health. Kindly send a copy of any publication that results from these data to PRACTICAL@icr.ac.uk Terms of use The nature of the data provided should not allow identification of individual subjects. By downloading these data, you agree not to attempt to identify individual subjects, or repost these data to a third party website without permission." UKB UK Biobank GWAS Hits Schumacher FR et al. 2019 29892016 https://www.ncbi.nlm.nih.gov/pubmed/?term=29892016 377 8.8e-246 0.0746154 0.0803 0.681 0.671-0.692 OR 4.85 3.95-5.95 4.85 3.95-5.95 4.07 3.48-4.76 4.07 3.48-4.76 3.79 3.4-4.23 3.79 3.4-4.23 3.5 3.21-3.83 3.5 3.21-3.83 3.05 2.83-3.3 3.05 2.83-3.3 1.74 1.5-2.03 6.33e-13 2.67 2.32-3.07 6.52e-42 5.51 4.82-6.28 2.51e-141 TRUE FALSE FALSE TRUE Male 3012 29652 GRCh37/hg19 P<=5e-08 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000582/ScoringFiles/ phewas/PRSWEB_PHECODE185_Pca-PRACTICAL_P_5e-08_UKB_20200608/all.tsv phewas/PRSWEB_PHECODE185_Pca-PRACTICAL_P_5e-08_UKB_20200608/exclusion.tsv 2020-06-08 prsweb-phecode185-gwas-catalog-r2019-05-03-x185-pt-ukb-20200608 prsweb-phecode185-gwas-catalog-r2019-05-03-x185-pt-ukb-20200608 PRSWEB_PHECODE185_GWAS-Catalog-r2019-05-03-X185_PT_UKB_20200608 P&T PRSWEB_PHECODE185_GWAS-Catalog-r2019-05-03-X185_PT_UKB_20200608 185 Prostate cancer;Prostate cancer (early onset) Binary 157 unique SNPs UKB UK Biobank P&T GWAS Catalog (2019-05-03) 17401363;17401366;17603485;18264096;18264097;18264098;19117981;19767754;21743057;21743467;23104005;23535732;24740154;25939597;27262462;29892016;30410027 https://www.ncbi.nlm.nih.gov/pubmed/?term=17401363+17401366+17603485+18264096+18264097+18264098+19117981+19767754+21743057+21743467+23104005+23535732+24740154+25939597+27262462+29892016+30410027 118 6.6e-186 0.0588082 0.0813 0.653 0.643-0.663 OR 4.34 3.51-5.37 4.34 3.51-5.37 3.87 3.3-4.54 3.87 3.3-4.54 3.08 2.74-3.45 3.08 2.74-3.45 2.87 2.62-3.14 2.87 2.62-3.14 2.63 2.44-2.84 2.63 2.44-2.84 1.57 1.36-1.81 3.07e-10 2.22 1.95-2.54 3.6e-32 4.2 3.71-4.75 6.13e-115 TRUE FALSE FALSE TRUE Male 3012 29652 GRCh37/hg19 P<=7.94e-08 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000580/ScoringFiles/ phewas/PRSWEB_PHECODE185_GWAS-Catalog-r2019-05-03-X185_PT_UKB_20200608/all.tsv phewas/PRSWEB_PHECODE185_GWAS-Catalog-r2019-05-03-X185_PT_UKB_20200608/exclusion.tsv 2020-06-08 prsweb-phecode185-pca-practical-pt-ukb-20200608 prsweb-phecode185-pca-practical-pt-ukb-20200608 PRSWEB_PHECODE185_Pca-PRACTICAL_PT_UKB_20200608 P&T PRSWEB_PHECODE185_Pca-PRACTICAL_PT_UKB_20200608 185 Prostate cancer Binary "Meta analysis summary data Meta summary association statistics for overall Prostate Cancer, as described in Schumacher, Al Olama, Berndt, et al. 2018 are provided. Acknowledgements When using these data, please cite: Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci. Schumacher, Al Olama, Berndt, et al. Nature Genetics 2018, acknowledge “The PRACTICAL consortium, CRUK, BPC3, CAPS, PEGASUS”, and include the following: The Prostate cancer genome-wide association analyses are supported by the Canadian Institutes of Health Research, European Commission’s Seventh Framework Programme grant agreement n° 223175 (HEALTH-F2-2009-223175), Cancer Research UK Grants C5047/A7357, C1287/A10118, C1287/A16563, C5047/A3354, C5047/A10692, C16913/A6135, and The National Institute of Health (NIH) Cancer Post-Cancer GWAS initiative grant: No. 1 U19 CA 148537-01 (the GAME-ON initiative). We would also like to thank the following for funding support: The Institute of Cancer Research and The Everyman Campaign, The Prostate Cancer Research Foundation, Prostate Research Campaign UK (now Prostate Action), The Orchid Cancer Appeal, The National Cancer Research Network UK, The National Cancer Research Institute (NCRI) UK. We are grateful for support of NIHR funding to the NIHR Biomedical Research Centre at The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust. The Prostate Cancer Program of Cancer Council Victoria also acknowledge grant support from The National Health and Medical Research Council, Australia (126402, 209057, 251533, , 396414, 450104, 504700, 504702, 504715, 623204, 940394, 614296,), VicHealth, Cancer Council Victoria, The Prostate Cancer Foundation of Australia, The Whitten Foundation, PricewaterhouseCoopers, and Tattersall’s. EAO, DMK, and EMK acknowledge the Intramural Program of the National Human Genome Research Institute for their support. Genotyping of the OncoArray was funded by the US National Institutes of Health (NIH) [U19 CA 148537 for ELucidating Loci Involved in Prostate cancer SuscEptibility (ELLIPSE) project and X01HG007492 to the Center for Inherited Disease Research (CIDR) under contract number HHSN268201200008I] and by Cancer Research UK grant A8197/A16565. Additional analytic support was provided by NIH NCI U01 CA188392 (PI: Schumacher). Funding for the iCOGS infrastructure came from: the European Community’s Seventh Framework Programme under grant agreement n° 223175 (HEALTH-F2-2009-223175) (COGS), Cancer Research UK (C1287/A10118, C1287/A 10710, C12292/A11174, C1281/A12014, C5047/A8384, C5047/A15007, C5047/A10692, C8197/A16565), the National Institutes of Health (CA128978) and Post-Cancer GWAS initiative (1U19 CA148537, 1U19 CA148065 and 1U19 CA148112 – the GAME-ON initiative), the Department of Defence (W81XWH-10-1-0341), the Canadian Institutes of Health Research (CIHR) for the CIHR Team in Familial Risks of Breast Cancer, Komen Foundation for the Cure, the Breast Cancer Research Foundation, and the Ovarian Cancer Research Fund. The BPC3 was supported by the U.S. National Institutes of Health, National Cancer Institute (cooperative agreements U01-CA98233 to D.J.H., U01-CA98710 to S.M.G., U01-CA98216 toE.R., and U01-CA98758 to B.E.H., and Intramural Research Program of NIH/National Cancer Institute, Division of Cancer Epidemiology and Genetics). CAPS GWAS study was supported by the Swedish Cancer Foundation (grant no 09-0677, 11-484, 12-823), the Cancer Risk Prediction Center (CRisP; www.crispcenter.org), a Linneus Centre (Contract ID 70867902) financed by the Swedish Research Council, Swedish Research Council (grant no K2010-70X-20430-04-3, 2014-2269) PEGASUS was supported by the Intramural Research Program, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health. Kindly send a copy of any publication that results from these data to PRACTICAL@icr.ac.uk Terms of use The nature of the data provided should not allow identification of individual subjects. By downloading these data, you agree not to attempt to identify individual subjects, or repost these data to a third party website without permission." UKB UK Biobank P&T Schumacher FR et al. 2019 29892016 https://www.ncbi.nlm.nih.gov/pubmed/?term=29892016 1023 6.7e-263 0.0802484 0.0799 0.687 0.678-0.698 OR 5.88 4.84-7.13 5.88 4.84-7.13 4.91 4.24-5.7 4.91 4.24-5.7 4.2 3.78-4.68 4.2 3.78-4.68 3.57 3.27-3.9 3.57 3.27-3.9 3.12 2.89-3.36 3.12 2.89-3.36 1.74 1.49-2.02 1.34e-12 2.73 2.37-3.15 2.42e-43 5.67 4.97-6.48 5e-144 TRUE FALSE FALSE TRUE Male 3012 29652 GRCh37/hg19 P<=2.51e-05 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000586/ScoringFiles/ phewas/PRSWEB_PHECODE185_Pca-PRACTICAL_PT_UKB_20200608/all.tsv phewas/PRSWEB_PHECODE185_Pca-PRACTICAL_PT_UKB_20200608/exclusion.tsv 2020-06-08 prsweb-phecode185-pca-practical-prs-cs-ukb-20200608 prsweb-phecode185-pca-practical-prs-cs-ukb-20200608 PRSWEB_PHECODE185_Pca-PRACTICAL_PRS-CS_UKB_20200608 PRS-CS PRSWEB_PHECODE185_Pca-PRACTICAL_PRS-CS_UKB_20200608 185 Prostate cancer Binary "Meta analysis summary data Meta summary association statistics for overall Prostate Cancer, as described in Schumacher, Al Olama, Berndt, et al. 2018 are provided. Acknowledgements When using these data, please cite: Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci. Schumacher, Al Olama, Berndt, et al. Nature Genetics 2018, acknowledge “The PRACTICAL consortium, CRUK, BPC3, CAPS, PEGASUS”, and include the following: The Prostate cancer genome-wide association analyses are supported by the Canadian Institutes of Health Research, European Commission’s Seventh Framework Programme grant agreement n° 223175 (HEALTH-F2-2009-223175), Cancer Research UK Grants C5047/A7357, C1287/A10118, C1287/A16563, C5047/A3354, C5047/A10692, C16913/A6135, and The National Institute of Health (NIH) Cancer Post-Cancer GWAS initiative grant: No. 1 U19 CA 148537-01 (the GAME-ON initiative). We would also like to thank the following for funding support: The Institute of Cancer Research and The Everyman Campaign, The Prostate Cancer Research Foundation, Prostate Research Campaign UK (now Prostate Action), The Orchid Cancer Appeal, The National Cancer Research Network UK, The National Cancer Research Institute (NCRI) UK. We are grateful for support of NIHR funding to the NIHR Biomedical Research Centre at The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust. The Prostate Cancer Program of Cancer Council Victoria also acknowledge grant support from The National Health and Medical Research Council, Australia (126402, 209057, 251533, , 396414, 450104, 504700, 504702, 504715, 623204, 940394, 614296,), VicHealth, Cancer Council Victoria, The Prostate Cancer Foundation of Australia, The Whitten Foundation, PricewaterhouseCoopers, and Tattersall’s. EAO, DMK, and EMK acknowledge the Intramural Program of the National Human Genome Research Institute for their support. Genotyping of the OncoArray was funded by the US National Institutes of Health (NIH) [U19 CA 148537 for ELucidating Loci Involved in Prostate cancer SuscEptibility (ELLIPSE) project and X01HG007492 to the Center for Inherited Disease Research (CIDR) under contract number HHSN268201200008I] and by Cancer Research UK grant A8197/A16565. Additional analytic support was provided by NIH NCI U01 CA188392 (PI: Schumacher). Funding for the iCOGS infrastructure came from: the European Community’s Seventh Framework Programme under grant agreement n° 223175 (HEALTH-F2-2009-223175) (COGS), Cancer Research UK (C1287/A10118, C1287/A 10710, C12292/A11174, C1281/A12014, C5047/A8384, C5047/A15007, C5047/A10692, C8197/A16565), the National Institutes of Health (CA128978) and Post-Cancer GWAS initiative (1U19 CA148537, 1U19 CA148065 and 1U19 CA148112 – the GAME-ON initiative), the Department of Defence (W81XWH-10-1-0341), the Canadian Institutes of Health Research (CIHR) for the CIHR Team in Familial Risks of Breast Cancer, Komen Foundation for the Cure, the Breast Cancer Research Foundation, and the Ovarian Cancer Research Fund. The BPC3 was supported by the U.S. National Institutes of Health, National Cancer Institute (cooperative agreements U01-CA98233 to D.J.H., U01-CA98710 to S.M.G., U01-CA98216 toE.R., and U01-CA98758 to B.E.H., and Intramural Research Program of NIH/National Cancer Institute, Division of Cancer Epidemiology and Genetics). CAPS GWAS study was supported by the Swedish Cancer Foundation (grant no 09-0677, 11-484, 12-823), the Cancer Risk Prediction Center (CRisP; www.crispcenter.org), a Linneus Centre (Contract ID 70867902) financed by the Swedish Research Council, Swedish Research Council (grant no K2010-70X-20430-04-3, 2014-2269) PEGASUS was supported by the Intramural Research Program, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health. Kindly send a copy of any publication that results from these data to PRACTICAL@icr.ac.uk Terms of use The nature of the data provided should not allow identification of individual subjects. By downloading these data, you agree not to attempt to identify individual subjects, or repost these data to a third party website without permission." UKB UK Biobank PRS-CS Schumacher FR et al. 2019 29892016 https://www.ncbi.nlm.nih.gov/pubmed/?term=29892016 1120596 1.1485369292536e-308 0.0927567 0.0791 0.705 0.695-0.715 OR 5.58 4.58-6.78 5.58 4.58-6.78 5.11 4.41-5.92 5.11 4.41-5.92 4.55 4.09-5.05 4.55 4.09-5.05 4.05 3.72-4.41 4.05 3.72-4.41 3.47 3.22-3.75 3.47 3.22-3.75 1.77 1.51-2.08 2.36e-12 2.93 2.53-3.4 8.44e-46 6.58 5.73-7.56 7.84e-158 TRUE FALSE FALSE TRUE Male 3012 29652 GRCh37/hg19 auto https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000584/ScoringFiles/ phewas/PRSWEB_PHECODE185_Pca-PRACTICAL_PRS-CS_UKB_20200608/all.tsv phewas/PRSWEB_PHECODE185_Pca-PRACTICAL_PRS-CS_UKB_20200608/exclusion.tsv 2020-06-08 prsweb-phecode185-pca-practical-lassosum-ukb-20200608 prsweb-phecode185-pca-practical-lassosum-ukb-20200608 PRSWEB_PHECODE185_Pca-PRACTICAL_LASSOSUM_UKB_20200608 Lassosum PRSWEB_PHECODE185_Pca-PRACTICAL_LASSOSUM_UKB_20200608 185 Prostate cancer Binary "Meta analysis summary data Meta summary association statistics for overall Prostate Cancer, as described in Schumacher, Al Olama, Berndt, et al. 2018 are provided. Acknowledgements When using these data, please cite: Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci. Schumacher, Al Olama, Berndt, et al. Nature Genetics 2018, acknowledge “The PRACTICAL consortium, CRUK, BPC3, CAPS, PEGASUS”, and include the following: The Prostate cancer genome-wide association analyses are supported by the Canadian Institutes of Health Research, European Commission’s Seventh Framework Programme grant agreement n° 223175 (HEALTH-F2-2009-223175), Cancer Research UK Grants C5047/A7357, C1287/A10118, C1287/A16563, C5047/A3354, C5047/A10692, C16913/A6135, and The National Institute of Health (NIH) Cancer Post-Cancer GWAS initiative grant: No. 1 U19 CA 148537-01 (the GAME-ON initiative). We would also like to thank the following for funding support: The Institute of Cancer Research and The Everyman Campaign, The Prostate Cancer Research Foundation, Prostate Research Campaign UK (now Prostate Action), The Orchid Cancer Appeal, The National Cancer Research Network UK, The National Cancer Research Institute (NCRI) UK. We are grateful for support of NIHR funding to the NIHR Biomedical Research Centre at The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust. The Prostate Cancer Program of Cancer Council Victoria also acknowledge grant support from The National Health and Medical Research Council, Australia (126402, 209057, 251533, , 396414, 450104, 504700, 504702, 504715, 623204, 940394, 614296,), VicHealth, Cancer Council Victoria, The Prostate Cancer Foundation of Australia, The Whitten Foundation, PricewaterhouseCoopers, and Tattersall’s. EAO, DMK, and EMK acknowledge the Intramural Program of the National Human Genome Research Institute for their support. Genotyping of the OncoArray was funded by the US National Institutes of Health (NIH) [U19 CA 148537 for ELucidating Loci Involved in Prostate cancer SuscEptibility (ELLIPSE) project and X01HG007492 to the Center for Inherited Disease Research (CIDR) under contract number HHSN268201200008I] and by Cancer Research UK grant A8197/A16565. Additional analytic support was provided by NIH NCI U01 CA188392 (PI: Schumacher). Funding for the iCOGS infrastructure came from: the European Community’s Seventh Framework Programme under grant agreement n° 223175 (HEALTH-F2-2009-223175) (COGS), Cancer Research UK (C1287/A10118, C1287/A 10710, C12292/A11174, C1281/A12014, C5047/A8384, C5047/A15007, C5047/A10692, C8197/A16565), the National Institutes of Health (CA128978) and Post-Cancer GWAS initiative (1U19 CA148537, 1U19 CA148065 and 1U19 CA148112 – the GAME-ON initiative), the Department of Defence (W81XWH-10-1-0341), the Canadian Institutes of Health Research (CIHR) for the CIHR Team in Familial Risks of Breast Cancer, Komen Foundation for the Cure, the Breast Cancer Research Foundation, and the Ovarian Cancer Research Fund. The BPC3 was supported by the U.S. National Institutes of Health, National Cancer Institute (cooperative agreements U01-CA98233 to D.J.H., U01-CA98710 to S.M.G., U01-CA98216 toE.R., and U01-CA98758 to B.E.H., and Intramural Research Program of NIH/National Cancer Institute, Division of Cancer Epidemiology and Genetics). CAPS GWAS study was supported by the Swedish Cancer Foundation (grant no 09-0677, 11-484, 12-823), the Cancer Risk Prediction Center (CRisP; www.crispcenter.org), a Linneus Centre (Contract ID 70867902) financed by the Swedish Research Council, Swedish Research Council (grant no K2010-70X-20430-04-3, 2014-2269) PEGASUS was supported by the Intramural Research Program, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health. Kindly send a copy of any publication that results from these data to PRACTICAL@icr.ac.uk Terms of use The nature of the data provided should not allow identification of individual subjects. By downloading these data, you agree not to attempt to identify individual subjects, or repost these data to a third party website without permission." UKB UK Biobank lassosum Schumacher FR et al. 2019 29892016 https://www.ncbi.nlm.nih.gov/pubmed/?term=29892016 178259 1.2e-292 0.0915226 0.0794 0.699 0.69-0.71 OR 5.88 4.85-7.14 5.88 4.85-7.14 4.81 4.14-5.58 4.81 4.14-5.58 4.4 3.96-4.89 4.4 3.96-4.89 3.89 3.57-4.25 3.89 3.57-4.25 3.35 3.11-3.62 3.35 3.11-3.62 1.66 1.42-1.94 2.12e-10 2.8 2.42-3.23 3.9e-44 6.07 5.31-6.95 6.19e-152 TRUE FALSE FALSE TRUE Male 3012 29652 GRCh37/hg19 s=0.9;Lambda=0.005456 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000588/ScoringFiles/ phewas/PRSWEB_PHECODE185_Pca-PRACTICAL_LASSOSUM_UKB_20200608/all.tsv phewas/PRSWEB_PHECODE185_Pca-PRACTICAL_LASSOSUM_UKB_20200608/exclusion.tsv 2020-06-08 prsweb-phecode187-c3-male-genital-p-5e-05-mgi-20200608 prsweb-phecode187-c3-male-genital-p-5e-05-mgi-20200608 PRSWEB_PHECODE187_C3-MALE-GENITAL_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE187_C3-MALE-GENITAL_P_5e-05_MGI_20200608 187 malignant neoplasm of male genital organs Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 276 0.13 0.000719868 0.0832 0.539 0.485-0.591 OR 1 0.175-5.71 1 0.175-5.71 0.514 0.0966-2.73 0.514 0.0966-2.73 1.09 0.503-2.38 1.09 0.503-2.38 1.21 0.704-2.09 1.21 0.704-2.09 1.35 0.92-1.97 1.35 0.92-1.97 0.631 0.367-1.08 0.0958 1.05 0.649-1.7 0.838 1.21 0.757-1.94 0.424 FALSE FALSE FALSE FALSE Male 137 1353 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode187-c3-male-genital-p-5e-06-mgi-20200608 prsweb-phecode187-c3-male-genital-p-5e-06-mgi-20200608 PRSWEB_PHECODE187_C3-MALE-GENITAL_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE187_C3-MALE-GENITAL_P_5e-06_MGI_20200608 187 malignant neoplasm of male genital organs Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 101 0.046 0.00295111 0.0831 0.551 0.5-0.599 OR 1.04 0.181-5.92 1.04 0.181-5.92 1.25 0.4-3.9 1.25 0.4-3.9 1.39 0.686-2.81 1.39 0.686-2.81 1.21 0.705-2.09 1.21 0.705-2.09 1.47 1.01-2.14 1.47 1.01-2.14 1.17 0.683-2.01 0.562 1.38 0.823-2.31 0.223 1.71 1.03-2.81 0.0363 TRUE FALSE FALSE FALSE Male 137 1353 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode187-c3-male-genital-p-5e-07-mgi-20200608 prsweb-phecode187-c3-male-genital-p-5e-07-mgi-20200608 PRSWEB_PHECODE187_C3-MALE-GENITAL_P_5e-07_MGI_20200608 P_5e-07 PRSWEB_PHECODE187_C3-MALE-GENITAL_P_5e-07_MGI_20200608 187 malignant neoplasm of male genital organs Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-07) UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 64 0.033 0.00107578 0.083 0.555 0.503-0.604 OR 1.03 0.181-5.88 1.03 0.181-5.88 0.852 0.228-3.19 0.852 0.228-3.19 1.25 0.598-2.61 1.25 0.598-2.61 1.29 0.759-2.2 1.29 0.759-2.2 1.62 1.12-2.35 1.62 1.12-2.35 0.866 0.511-1.47 0.592 0.99 0.594-1.65 0.969 1.55 0.965-2.48 0.0698 TRUE FALSE FALSE FALSE Male 137 1353 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode187-c3-male-genital-p-5e-09-mgi-20200608 prsweb-phecode187-c3-male-genital-p-5e-09-mgi-20200608 PRSWEB_PHECODE187_C3-MALE-GENITAL_P_5e-09_MGI_20200608 P_5e-09 PRSWEB_PHECODE187_C3-MALE-GENITAL_P_5e-09_MGI_20200608 187 malignant neoplasm of male genital organs Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-09) UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 36 0.14 0.000322193 0.0832 0.536 0.482-0.587 OR 2.31 0.684-7.82 2.31 0.684-7.82 1.19 0.382-3.73 1.19 0.382-3.73 0.939 0.411-2.14 0.939 0.411-2.14 1.2 0.696-2.06 1.2 0.696-2.06 1.38 0.942-2.01 1.38 0.942-2.01 0.987 0.59-1.65 0.961 1.06 0.642-1.76 0.814 1.38 0.85-2.23 0.194 FALSE FALSE FALSE FALSE Male 137 1353 GRCh37/hg19 P<=5e-09 2020-06-08 prsweb-phecode187-c3-male-genital-p-5e-08-mgi-20200608 prsweb-phecode187-c3-male-genital-p-5e-08-mgi-20200608 PRSWEB_PHECODE187_C3-MALE-GENITAL_P_5e-08_MGI_20200608 P_5e-08 PRSWEB_PHECODE187_C3-MALE-GENITAL_P_5e-08_MGI_20200608 187 malignant neoplasm of male genital organs Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative GWAS Hits UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 45 0.047 0.000268263 0.0831 0.551 0.5-0.6 OR 1.01 0.177-5.76 1.01 0.177-5.76 0.846 0.226-3.17 0.846 0.226-3.17 1.39 0.687-2.81 1.39 0.687-2.81 1.28 0.751-2.18 1.28 0.751-2.18 1.47 1.01-2.14 1.47 1.01-2.14 1.01 0.59-1.72 0.976 1.3 0.783-2.17 0.309 1.59 0.974-2.6 0.0636 TRUE FALSE FALSE TRUE Male 137 1353 GRCh37/hg19 P<=5e-08 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000593/ScoringFiles/ phewas/PRSWEB_PHECODE187_C3-MALE-GENITAL_P_5e-08_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE187_C3-MALE-GENITAL_P_5e-08_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode187-c3-male-genital-pt-mgi-20200608 prsweb-phecode187-c3-male-genital-pt-mgi-20200608 PRSWEB_PHECODE187_C3-MALE-GENITAL_PT_MGI_20200608 P&T PRSWEB_PHECODE187_C3-MALE-GENITAL_PT_MGI_20200608 187 malignant neoplasm of male genital organs Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative P&T UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 97 0.023 0.00316843 0.083 0.558 0.506-0.606 OR 1.04 0.183-5.95 1.04 0.183-5.95 1.23 0.395-3.85 1.23 0.395-3.85 1.68 0.875-3.24 1.68 0.875-3.24 1.21 0.705-2.09 1.21 0.705-2.09 1.47 1.01-2.13 1.47 1.01-2.13 1.32 0.771-2.28 0.309 1.5 0.883-2.53 0.134 1.87 1.12-3.11 0.0167 TRUE FALSE FALSE TRUE Male 137 1353 GRCh37/hg19 P<=3.98e-06 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000594/ScoringFiles/ phewas/PRSWEB_PHECODE187_C3-MALE-GENITAL_PT_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE187_C3-MALE-GENITAL_PT_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode187-c3-male-genital-prs-cs-mgi-20200608 prsweb-phecode187-c3-male-genital-prs-cs-mgi-20200608 PRSWEB_PHECODE187_C3-MALE-GENITAL_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE187_C3-MALE-GENITAL_PRS-CS_MGI_20200608 187 malignant neoplasm of male genital organs Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative PRS-CS UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1111493 0.46 0.00137582 0.0833 0.519 0.47-0.57 OR 1.67 0.416-6.72 1.67 0.416-6.72 1.56 0.56-4.32 1.56 0.56-4.32 1.21 0.577-2.52 1.21 0.577-2.52 0.954 0.53-1.72 0.954 0.53-1.72 0.947 0.631-1.42 0.947 0.631-1.42 1.17 0.697-1.95 0.557 1.53 0.934-2.5 0.0911 1.17 0.697-1.96 0.555 FALSE FALSE FALSE FALSE Male 137 1353 GRCh37/hg19 auto 2020-06-08 prsweb-phecode187-2-20001-1045-p-5e-05-mgi-20200608 prsweb-phecode187-2-20001-1045-p-5e-05-mgi-20200608 PRSWEB_PHECODE187.2_20001-1045_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE187.2_20001-1045_P_5e-05_MGI_20200608 187.2 Cancer code, self-reported: testicular cancer Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 135 0.0031 0.00244323 0.0846 0.608 0.539-0.676 OR 3.42 0.74-15.8 3.42 0.74-15.8 3.3 1.08-10.1 3.3 1.08-10.1 1.9 0.782-4.61 1.9 0.782-4.61 2.2 1.17-4.14 2.2 1.17-4.14 1.77 1.07-2.92 1.77 1.07-2.92 1.34 0.618-2.92 0.456 1.64 0.779-3.46 0.193 2.34 1.14-4.84 0.0212 TRUE FALSE FALSE FALSE Male 73 682 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode187-2-c3-testis-p-5e-05-mgi-20200608 prsweb-phecode187-2-c3-testis-p-5e-05-mgi-20200608 PRSWEB_PHECODE187.2_C3-TESTIS_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE187.2_C3-TESTIS_P_5e-05_MGI_20200608 187.2 Malignant neoplasm of testis Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 113 0.0024 0.0162497 0.0846 0.606 0.526-0.682 OR 0 0-0 0 0-0 2.88 0.937-8.86 2.88 0.937-8.86 4.27 2.17-8.41 4.27 2.17-8.41 3.16 1.76-5.66 3.16 1.76-5.66 2.1 1.28-3.44 2.1 1.28-3.44 1.32 0.625-2.8 0.466 1.07 0.493-2.34 0.859 2.31 1.16-4.58 0.0167 TRUE FALSE FALSE FALSE Male 73 682 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode187-2-c62-p-5e-05-mgi-20200608 prsweb-phecode187-2-c62-p-5e-05-mgi-20200608 PRSWEB_PHECODE187.2_C62_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE187.2_C62_P_5e-05_MGI_20200608 187.2 Diagnoses - main ICD10: C62 Malignant neoplasm of testis Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 76 0.38 0.000264435 0.086 0.532 0.459-0.598 OR 0 0-0 0 0-0 0.32 0.0178-5.75 0.32 0.0178-5.75 0.835 0.267-2.62 0.835 0.267-2.62 0.918 0.412-2.05 0.918 0.412-2.05 1.02 0.594-1.77 1.02 0.594-1.77 0.855 0.404-1.81 0.683 1.66 0.859-3.22 0.131 1.23 0.611-2.47 0.565 FALSE FALSE FALSE FALSE Male 73 682 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode187-2-gwas-catalog-r2019-05-03-x187-2-p-5e-05-mgi-20200608 prsweb-phecode187-2-gwas-catalog-r2019-05-03-x187-2-p-5e-05-mgi-20200608 PRSWEB_PHECODE187.2_GWAS-Catalog-r2019-05-03-X187.2_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE187.2_GWAS-Catalog-r2019-05-03-X187.2_P_5e-05_MGI_20200608 187.2 Testicular germ cell tumor;Testicular germ cell cancer Binary 51 unique SNPs MGI Michigan Genomics Initiative Fixed threshold (5e-05) GWAS Catalog (2019-05-03) 19483681;20543847;23666239;23666240;25877299;26503584;28604728;28604732 https://www.ncbi.nlm.nih.gov/pubmed/?term=19483681+20543847+23666239+23666240+25877299+26503584+28604728+28604732 46 0.0033 0.0115383 0.0851 0.599 0.529-0.67 OR 0 0-0 0 0-0 2.41 0.705-8.22 2.41 0.705-8.22 2.99 1.42-6.31 2.99 1.42-6.31 2.56 1.39-4.7 2.56 1.39-4.7 1.81 1.1-2.99 1.81 1.1-2.99 1.1 0.519-2.35 0.797 1.35 0.65-2.81 0.42 1.93 0.973-3.83 0.0599 TRUE FALSE FALSE FALSE Male 73 682 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode187-2-ukbb-saige-hrc-x187-2-p-5e-05-mgi-20200608 prsweb-phecode187-2-ukbb-saige-hrc-x187-2-p-5e-05-mgi-20200608 PRSWEB_PHECODE187.2_UKBB-SAIGE-HRC-X187.2_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE187.2_UKBB-SAIGE-HRC-X187.2_P_5e-05_MGI_20200608 187.2 Malignant neoplasm of testis Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 155 0.27 0.000104252 0.086 0.552 0.48-0.618 OR 0 0-0 0 0-0 1.4 0.33-5.92 1.4 0.33-5.92 1.11 0.395-3.12 1.11 0.395-3.12 1.26 0.61-2.62 1.26 0.61-2.62 1.28 0.756-2.16 1.28 0.756-2.16 0.901 0.42-1.93 0.788 1.73 0.875-3.42 0.115 1.37 0.688-2.75 0.368 FALSE FALSE FALSE FALSE Male 73 682 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode187-2-20001-1045-p-5e-06-mgi-20200608 prsweb-phecode187-2-20001-1045-p-5e-06-mgi-20200608 PRSWEB_PHECODE187.2_20001-1045_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE187.2_20001-1045_P_5e-06_MGI_20200608 187.2 Cancer code, self-reported: testicular cancer Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 27 6e-05 0.0182087 0.0836 0.643 0.574-0.713 OR 3.44 0.735-16.1 3.44 0.735-16.1 2.2 0.632-7.69 2.2 0.632-7.69 2.7 1.24-5.87 2.7 1.24-5.87 3.22 1.8-5.75 3.22 1.8-5.75 2.61 1.6-4.25 2.61 1.6-4.25 2.54 1.07-6.02 0.0337 1.92 0.793-4.63 0.149 4.46 1.99-9.98 0.000272 TRUE FALSE FALSE FALSE Male 73 682 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode187-2-c3-testis-p-5e-06-mgi-20200608 prsweb-phecode187-2-c3-testis-p-5e-06-mgi-20200608 PRSWEB_PHECODE187.2_C3-TESTIS_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE187.2_C3-TESTIS_P_5e-06_MGI_20200608 187.2 Malignant neoplasm of testis Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 22 0.00012 0.0306466 0.0845 0.636 0.571-0.7 OR 2.24 0.344-14.6 2.24 0.344-14.6 2.09 0.6-7.26 2.09 0.6-7.26 3.1 1.49-6.43 3.1 1.49-6.43 2.62 1.44-4.77 2.62 1.44-4.77 2.63 1.62-4.29 2.63 1.62-4.29 1.58 0.712-3.52 0.26 1.33 0.576-3.07 0.504 3.13 1.53-6.38 0.00172 TRUE FALSE FALSE FALSE Male 73 682 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode187-2-c62-p-5e-06-mgi-20200608 prsweb-phecode187-2-c62-p-5e-06-mgi-20200608 PRSWEB_PHECODE187.2_C62_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE187.2_C62_P_5e-06_MGI_20200608 187.2 Diagnoses - main ICD10: C62 Malignant neoplasm of testis Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 13 0.4 0.000755363 0.086 0.534 0.468-0.604 OR 1.53 0.217-10.8 1.53 0.217-10.8 0.832 0.141-4.9 0.832 0.141-4.9 0.583 0.156-2.18 0.583 0.156-2.18 0.962 0.433-2.14 0.962 0.433-2.14 0.976 0.562-1.7 0.976 0.562-1.7 0.964 0.452-2.06 0.925 1.95 1.01-3.76 0.0464 1.16 0.557-2.41 0.695 FALSE FALSE FALSE FALSE Male 73 682 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode187-2-gwas-catalog-r2019-05-03-x187-2-p-5e-06-mgi-20200608 prsweb-phecode187-2-gwas-catalog-r2019-05-03-x187-2-p-5e-06-mgi-20200608 PRSWEB_PHECODE187.2_GWAS-Catalog-r2019-05-03-X187.2_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE187.2_GWAS-Catalog-r2019-05-03-X187.2_P_5e-06_MGI_20200608 187.2 Testicular germ cell tumor;Testicular germ cell cancer Binary 51 unique SNPs MGI Michigan Genomics Initiative Fixed threshold (5e-06) GWAS Catalog (2019-05-03) 19483681;20543847;23666239;23666240;25877299;26503584;28604728;28604732 https://www.ncbi.nlm.nih.gov/pubmed/?term=19483681+20543847+23666239+23666240+25877299+26503584+28604728+28604732 44 0.0041 0.0104803 0.085 0.594 0.526-0.666 OR 0 0-0 0 0-0 2.83 0.909-8.81 2.83 0.909-8.81 3.39 1.64-7.01 3.39 1.64-7.01 2.92 1.62-5.26 2.92 1.62-5.26 1.92 1.17-3.16 1.92 1.17-3.16 1.17 0.543-2.51 0.692 1.25 0.598-2.62 0.551 2.03 1.02-4.02 0.0423 TRUE FALSE FALSE FALSE Male 73 682 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode187-2-ukbb-saige-hrc-x187-2-p-5e-06-mgi-20200608 prsweb-phecode187-2-ukbb-saige-hrc-x187-2-p-5e-06-mgi-20200608 PRSWEB_PHECODE187.2_UKBB-SAIGE-HRC-X187.2_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE187.2_UKBB-SAIGE-HRC-X187.2_P_5e-06_MGI_20200608 187.2 Malignant neoplasm of testis Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 41 0.52 0.00296752 0.0861 0.525 0.461-0.588 OR 0 0-0 0 0-0 0.905 0.157-5.21 0.905 0.157-5.21 0.639 0.172-2.37 0.639 0.172-2.37 0.587 0.219-1.57 0.587 0.219-1.57 1.13 0.649-1.95 1.13 0.649-1.95 1.27 0.624-2.58 0.511 1.42 0.712-2.85 0.318 1.4 0.681-2.88 0.359 FALSE FALSE FALSE FALSE Male 73 682 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode187-2-20001-1045-p-5e-07-mgi-20200608 prsweb-phecode187-2-20001-1045-p-5e-07-mgi-20200608 PRSWEB_PHECODE187.2_20001-1045_P_5e-07_MGI_20200608 P_5e-07 PRSWEB_PHECODE187.2_20001-1045_P_5e-07_MGI_20200608 187.2 Cancer code, self-reported: testicular cancer Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-07) UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 13 2.7e-05 0.0193501 0.0835 0.663 0.594-0.729 OR 1.9 0.288-12.5 1.9 0.288-12.5 1.92 0.541-6.84 1.92 0.541-6.84 2.13 0.939-4.84 2.13 0.939-4.84 3.39 1.92-5.98 3.39 1.92-5.98 2.93 1.8-4.77 2.93 1.8-4.77 1.05 0.447-2.45 0.917 1.48 0.669-3.3 0.332 3.37 1.66-6.84 0.000797 TRUE FALSE FALSE FALSE Male 73 682 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode187-2-c3-testis-p-5e-07-mgi-20200608 prsweb-phecode187-2-c3-testis-p-5e-07-mgi-20200608 PRSWEB_PHECODE187.2_C3-TESTIS_P_5e-07_MGI_20200608 P_5e-07 PRSWEB_PHECODE187.2_C3-TESTIS_P_5e-07_MGI_20200608 187.2 Malignant neoplasm of testis Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-07) UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 8 0.0026 0.0229326 0.0849 0.618 0.553-0.684 OR 2.66 0.549-12.9 2.66 0.549-12.9 2.01 0.57-7.11 2.01 0.57-7.11 1.97 0.846-4.57 1.97 0.846-4.57 1.73 0.883-3.37 1.73 0.883-3.37 1.76 1.07-2.91 1.76 1.07-2.91 0.902 0.396-2.05 0.805 1.97 0.957-4.05 0.0656 2.29 1.12-4.65 0.0224 TRUE FALSE FALSE FALSE Male 73 682 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode187-2-c62-p-5e-07-mgi-20200608 prsweb-phecode187-2-c62-p-5e-07-mgi-20200608 PRSWEB_PHECODE187.2_C62_P_5e-07_MGI_20200608 P_5e-07 PRSWEB_PHECODE187.2_C62_P_5e-07_MGI_20200608 187.2 Diagnoses - main ICD10: C62 Malignant neoplasm of testis Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-07) UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 5 0.36 0.00165989 0.086 0.529 0.461-0.601 OR 0 0-0 0 0-0 0.951 0.166-5.44 0.951 0.166-5.44 1.23 0.469-3.24 1.23 0.469-3.24 0.654 0.262-1.63 0.654 0.262-1.63 1.18 0.697-2.01 1.18 0.697-2.01 1.54 0.765-3.1 0.227 1.29 0.636-2.62 0.478 1.41 0.699-2.84 0.337 FALSE FALSE FALSE FALSE Male 73 682 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode187-2-gwas-catalog-r2019-05-03-x187-2-p-5e-07-mgi-20200608 prsweb-phecode187-2-gwas-catalog-r2019-05-03-x187-2-p-5e-07-mgi-20200608 PRSWEB_PHECODE187.2_GWAS-Catalog-r2019-05-03-X187.2_P_5e-07_MGI_20200608 P_5e-07 PRSWEB_PHECODE187.2_GWAS-Catalog-r2019-05-03-X187.2_P_5e-07_MGI_20200608 187.2 Testicular germ cell tumor;Testicular germ cell cancer Binary 51 unique SNPs MGI Michigan Genomics Initiative Fixed threshold (5e-07) GWAS Catalog (2019-05-03) 19483681;20543847;23666239;23666240;25877299;26503584;28604728;28604732 https://www.ncbi.nlm.nih.gov/pubmed/?term=19483681+20543847+23666239+23666240+25877299+26503584+28604728+28604732 42 0.0057 0.0095665 0.0851 0.59 0.521-0.665 OR 0 0-0 0 0-0 3.17 1.03-9.73 3.17 1.03-9.73 3.68 1.82-7.48 3.68 1.82-7.48 2.31 1.24-4.28 2.31 1.24-4.28 1.85 1.12-3.06 1.85 1.12-3.06 1.03 0.477-2.23 0.939 1.44 0.697-2.97 0.325 2.05 1.03-4.08 0.0412 TRUE FALSE FALSE FALSE Male 73 682 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode187-2-ukbb-saige-hrc-x187-2-p-5e-07-mgi-20200608 prsweb-phecode187-2-ukbb-saige-hrc-x187-2-p-5e-07-mgi-20200608 PRSWEB_PHECODE187.2_UKBB-SAIGE-HRC-X187.2_P_5e-07_MGI_20200608 P_5e-07 PRSWEB_PHECODE187.2_UKBB-SAIGE-HRC-X187.2_P_5e-07_MGI_20200608 187.2 Malignant neoplasm of testis Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative Fixed threshold (5e-07) UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 22 0.66 0.00188642 0.0862 0.505 0.441-0.566 OR 0 0-0 0 0-0 0.885 0.154-5.07 0.885 0.154-5.07 0.878 0.282-2.73 0.878 0.282-2.73 0.982 0.443-2.18 0.982 0.443-2.18 0.794 0.442-1.43 0.794 0.442-1.43 1.72 0.881-3.37 0.112 1.29 0.634-2.62 0.483 1.02 0.474-2.18 0.965 FALSE FALSE FALSE FALSE Male 73 682 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode187-2-20001-1045-p-5e-09-mgi-20200608 prsweb-phecode187-2-20001-1045-p-5e-09-mgi-20200608 PRSWEB_PHECODE187.2_20001-1045_P_5e-09_MGI_20200608 P_5e-09 PRSWEB_PHECODE187.2_20001-1045_P_5e-09_MGI_20200608 187.2 Cancer code, self-reported: testicular cancer Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-09) UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 7 0.00012 0.0262156 0.0841 0.65 0.587-0.713 OR 4.93 1.29-18.8 4.93 1.29-18.8 4.2 1.5-11.7 4.2 1.5-11.7 2.57 1.18-5.6 2.57 1.18-5.6 1.74 0.894-3.37 1.74 0.894-3.37 2.52 1.55-4.11 2.52 1.55-4.11 1.81 0.755-4.32 0.184 2.45 1.05-5.7 0.0376 4.48 2-10 0.000266 TRUE FALSE FALSE FALSE Male 73 682 GRCh37/hg19 P<=5e-09 2020-06-08 prsweb-phecode187-2-c3-testis-p-5e-09-mgi-20200608 prsweb-phecode187-2-c3-testis-p-5e-09-mgi-20200608 PRSWEB_PHECODE187.2_C3-TESTIS_P_5e-09_MGI_20200608 P_5e-09 PRSWEB_PHECODE187.2_C3-TESTIS_P_5e-09_MGI_20200608 187.2 Malignant neoplasm of testis Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-09) UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 5 0.00018 0.031599 0.0839 0.651 0.585-0.715 OR 4.29 1.1-16.8 4.29 1.1-16.8 2.91 0.948-8.95 2.91 0.948-8.95 2.45 1.12-5.36 2.45 1.12-5.36 2.83 1.57-5.1 2.83 1.57-5.1 2.5 1.53-4.08 2.5 1.53-4.08 1.24 0.533-2.9 0.616 2.04 0.926-4.51 0.0769 3.28 1.56-6.88 0.00169 TRUE FALSE FALSE FALSE Male 73 682 GRCh37/hg19 P<=5e-09 2020-06-08 prsweb-phecode187-2-gwas-catalog-r2019-05-03-x187-2-p-5e-09-mgi-20200608 prsweb-phecode187-2-gwas-catalog-r2019-05-03-x187-2-p-5e-09-mgi-20200608 PRSWEB_PHECODE187.2_GWAS-Catalog-r2019-05-03-X187.2_P_5e-09_MGI_20200608 P_5e-09 PRSWEB_PHECODE187.2_GWAS-Catalog-r2019-05-03-X187.2_P_5e-09_MGI_20200608 187.2 Testicular germ cell tumor;Testicular germ cell cancer Binary 51 unique SNPs MGI Michigan Genomics Initiative Fixed threshold (5e-09) GWAS Catalog (2019-05-03) 19483681;20543847;23666239;23666240;25877299;26503584;28604728;28604732 https://www.ncbi.nlm.nih.gov/pubmed/?term=19483681+20543847+23666239+23666240+25877299+26503584+28604728+28604732 31 0.00072 0.0108001 0.0844 0.606 0.533-0.679 OR 4.83 1.23-18.9 4.83 1.23-18.9 4.83 1.8-13 4.83 1.8-13 3.73 1.83-7.61 3.73 1.83-7.61 2.68 1.47-4.86 2.68 1.47-4.86 1.97 1.2-3.24 1.97 1.2-3.24 1.71 0.806-3.61 0.163 1.25 0.571-2.74 0.577 2.56 1.25-5.25 0.0104 TRUE FALSE FALSE FALSE Male 73 682 GRCh37/hg19 P<=5e-09 2020-06-08 prsweb-phecode187-2-20001-1045-p-5e-08-mgi-20200608 prsweb-phecode187-2-20001-1045-p-5e-08-mgi-20200608 PRSWEB_PHECODE187.2_20001-1045_P_5e-08_MGI_20200608 P_5e-08 PRSWEB_PHECODE187.2_20001-1045_P_5e-08_MGI_20200608 187.2 Cancer code, self-reported: testicular cancer Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative GWAS Hits UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 9 3.1e-05 0.0241313 0.0838 0.658 0.594-0.719 OR 2.64 0.535-13 2.64 0.535-13 3.41 1.17-9.99 3.41 1.17-9.99 2.56 1.17-5.59 2.56 1.17-5.59 2.11 1.12-3.97 2.11 1.12-3.97 2.51 1.55-4.09 2.51 1.55-4.09 1.64 0.697-3.87 0.257 2.06 0.911-4.65 0.0827 3.96 1.84-8.53 0.000445 TRUE FALSE FALSE TRUE Male 73 682 GRCh37/hg19 P<=5e-08 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000595/ScoringFiles/ phewas/PRSWEB_PHECODE187.2_20001-1045_P_5e-08_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE187.2_20001-1045_P_5e-08_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode187-2-c3-testis-p-5e-08-mgi-20200608 prsweb-phecode187-2-c3-testis-p-5e-08-mgi-20200608 PRSWEB_PHECODE187.2_C3-TESTIS_P_5e-08_MGI_20200608 P_5e-08 PRSWEB_PHECODE187.2_C3-TESTIS_P_5e-08_MGI_20200608 187.2 Malignant neoplasm of testis Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative GWAS Hits UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 6 2e-04 0.028776 0.0841 0.648 0.581-0.712 OR 3.85 0.942-15.7 3.85 0.942-15.7 2.65 0.828-8.45 2.65 0.828-8.45 2.86 1.34-6.12 2.86 1.34-6.12 2.06 1.09-3.88 2.06 1.09-3.88 2.68 1.65-4.36 2.68 1.65-4.36 0.976 0.42-2.27 0.954 1.59 0.738-3.45 0.235 3.19 1.56-6.51 0.00149 TRUE FALSE FALSE TRUE Male 73 682 GRCh37/hg19 P<=5e-08 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000598/ScoringFiles/ phewas/PRSWEB_PHECODE187.2_C3-TESTIS_P_5e-08_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE187.2_C3-TESTIS_P_5e-08_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode187-2-gwas-catalog-r2019-05-03-x187-2-p-5e-08-mgi-20200608 prsweb-phecode187-2-gwas-catalog-r2019-05-03-x187-2-p-5e-08-mgi-20200608 PRSWEB_PHECODE187.2_GWAS-Catalog-r2019-05-03-X187.2_P_5e-08_MGI_20200608 P_5e-08 PRSWEB_PHECODE187.2_GWAS-Catalog-r2019-05-03-X187.2_P_5e-08_MGI_20200608 187.2 Testicular germ cell tumor;Testicular germ cell cancer Binary 51 unique SNPs MGI Michigan Genomics Initiative GWAS Hits GWAS Catalog (2019-05-03) 19483681;20543847;23666239;23666240;25877299;26503584;28604728;28604732 https://www.ncbi.nlm.nih.gov/pubmed/?term=19483681+20543847+23666239+23666240+25877299+26503584+28604728+28604732 40 0.003 0.00908486 0.085 0.598 0.526-0.672 OR 0 0-0 0 0-0 1.69 0.416-6.86 1.69 0.416-6.86 4.03 2.01-8.05 4.03 2.01-8.05 2.69 1.48-4.88 2.69 1.48-4.88 1.86 1.13-3.07 1.86 1.13-3.07 0.858 0.391-1.88 0.703 1.15 0.57-2.33 0.691 1.73 0.892-3.35 0.105 TRUE FALSE FALSE TRUE Male 73 682 GRCh37/hg19 P<=5e-08 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000601/ScoringFiles/ phewas/PRSWEB_PHECODE187.2_GWAS-Catalog-r2019-05-03-X187.2_P_5e-08_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE187.2_GWAS-Catalog-r2019-05-03-X187.2_P_5e-08_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode187-2-20001-1045-pt-mgi-20200608 prsweb-phecode187-2-20001-1045-pt-mgi-20200608 PRSWEB_PHECODE187.2_20001-1045_PT_MGI_20200608 P&T PRSWEB_PHECODE187.2_20001-1045_PT_MGI_20200608 187.2 Cancer code, self-reported: testicular cancer Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative P&T UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 5 0.00019 0.0308642 0.0841 0.649 0.586-0.714 OR 3.49 0.816-14.9 3.49 0.816-14.9 1.89 0.524-6.82 1.89 0.524-6.82 2.1 0.922-4.8 2.1 0.922-4.8 2.97 1.66-5.33 2.97 1.66-5.33 1.7 1.03-2.81 1.7 1.03-2.81 0.864 0.362-2.06 0.743 2.67 1.29-5.56 0.00834 2.49 1.19-5.19 0.0152 TRUE FALSE FALSE TRUE Male 73 682 GRCh37/hg19 P<=5.01e-11 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000596/ScoringFiles/ phewas/PRSWEB_PHECODE187.2_20001-1045_PT_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE187.2_20001-1045_PT_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode187-2-c3-testis-pt-mgi-20200608 prsweb-phecode187-2-c3-testis-pt-mgi-20200608 PRSWEB_PHECODE187.2_C3-TESTIS_PT_MGI_20200608 P&T PRSWEB_PHECODE187.2_C3-TESTIS_PT_MGI_20200608 187.2 Malignant neoplasm of testis Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative P&T UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 31 6.9e-05 0.0375784 0.0844 0.637 0.568-0.703 OR 4.35 1.08-17.5 4.35 1.08-17.5 3.58 1.23-10.4 3.58 1.23-10.4 2.83 1.34-5.98 2.83 1.34-5.98 2.84 1.58-5.11 2.84 1.58-5.11 2.41 1.48-3.93 2.41 1.48-3.93 1.66 0.729-3.79 0.228 1.72 0.764-3.89 0.19 3.4 1.62-7.14 0.00124 TRUE FALSE FALSE TRUE Male 73 682 GRCh37/hg19 P<=1e-05 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000599/ScoringFiles/ phewas/PRSWEB_PHECODE187.2_C3-TESTIS_PT_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE187.2_C3-TESTIS_PT_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode187-2-c62-pt-mgi-20200608 prsweb-phecode187-2-c62-pt-mgi-20200608 PRSWEB_PHECODE187.2_C62_PT_MGI_20200608 P&T PRSWEB_PHECODE187.2_C62_PT_MGI_20200608 187.2 Diagnoses - main ICD10: C62 Malignant neoplasm of testis Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative P&T UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 10 0.38 0.00242253 0.086 0.528 0.459-0.597 OR 1.68 0.25-11.2 1.68 0.25-11.2 0.901 0.156-5.19 0.901 0.156-5.19 1.09 0.391-3.07 1.09 0.391-3.07 0.691 0.28-1.71 0.691 0.28-1.71 1.27 0.753-2.15 1.27 0.753-2.15 0.722 0.344-1.51 0.388 1.27 0.662-2.45 0.47 1.15 0.59-2.24 0.682 FALSE FALSE FALSE FALSE Male 73 682 GRCh37/hg19 P<=3.16e-06 2020-06-08 prsweb-phecode187-2-gwas-catalog-r2019-05-03-x187-2-pt-mgi-20200608 prsweb-phecode187-2-gwas-catalog-r2019-05-03-x187-2-pt-mgi-20200608 PRSWEB_PHECODE187.2_GWAS-Catalog-r2019-05-03-X187.2_PT_MGI_20200608 P&T PRSWEB_PHECODE187.2_GWAS-Catalog-r2019-05-03-X187.2_PT_MGI_20200608 187.2 Testicular germ cell tumor;Testicular germ cell cancer Binary 51 unique SNPs MGI Michigan Genomics Initiative P&T GWAS Catalog (2019-05-03) 19483681;20543847;23666239;23666240;25877299;26503584;28604728;28604732 https://www.ncbi.nlm.nih.gov/pubmed/?term=19483681+20543847+23666239+23666240+25877299+26503584+28604728+28604732 22 0.00012 0.0136253 0.084 0.625 0.557-0.693 OR 6.05 1.73-21.2 6.05 1.73-21.2 5.18 1.98-13.5 5.18 1.98-13.5 4.14 2.07-8.28 4.14 2.07-8.28 2.96 1.64-5.32 2.96 1.64-5.32 2.17 1.32-3.55 2.17 1.32-3.55 1.98 0.893-4.38 0.0929 1.69 0.75-3.82 0.205 3.19 1.49-6.86 0.0029 TRUE FALSE FALSE TRUE Male 73 682 GRCh37/hg19 P<=2.51e-11 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000603/ScoringFiles/ phewas/PRSWEB_PHECODE187.2_GWAS-Catalog-r2019-05-03-X187.2_PT_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE187.2_GWAS-Catalog-r2019-05-03-X187.2_PT_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode187-2-ukbb-saige-hrc-x187-2-pt-mgi-20200608 prsweb-phecode187-2-ukbb-saige-hrc-x187-2-pt-mgi-20200608 PRSWEB_PHECODE187.2_UKBB-SAIGE-HRC-X187.2_PT_MGI_20200608 P&T PRSWEB_PHECODE187.2_UKBB-SAIGE-HRC-X187.2_PT_MGI_20200608 187.2 Malignant neoplasm of testis Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative P&T UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 48 0.8 0.00426687 0.0862 0.512 0.447-0.574 OR 0 0-0 0 0-0 1.39 0.335-5.77 1.39 0.335-5.77 0.868 0.279-2.71 0.868 0.279-2.71 0.444 0.148-1.33 0.444 0.148-1.33 1.46 0.86-2.47 1.46 0.86-2.47 0.973 0.486-1.95 0.939 0.837 0.409-1.71 0.627 1.23 0.633-2.38 0.544 FALSE FALSE FALSE FALSE Male 73 682 GRCh37/hg19 P<=6.31e-06 2020-06-08 prsweb-phecode187-2-20001-1045-prs-cs-mgi-20200608 prsweb-phecode187-2-20001-1045-prs-cs-mgi-20200608 PRSWEB_PHECODE187.2_20001-1045_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE187.2_20001-1045_PRS-CS_MGI_20200608 187.2 Cancer code, self-reported: testicular cancer Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative PRS-CS UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1084569 0.29 0.00765996 0.0859 0.539 0.462-0.614 OR 0 0-0 0 0-0 1.68 0.41-6.91 1.68 0.41-6.91 2.16 0.932-5.01 2.16 0.932-5.01 1.49 0.736-3 1.49 0.736-3 1.53 0.922-2.55 1.53 0.922-2.55 0.991 0.494-1.99 0.981 1.03 0.51-2.07 0.938 1.44 0.739-2.8 0.285 FALSE FALSE FALSE FALSE Male 73 682 GRCh37/hg19 auto 2020-06-08 prsweb-phecode187-2-c3-testis-prs-cs-mgi-20200608 prsweb-phecode187-2-c3-testis-prs-cs-mgi-20200608 PRSWEB_PHECODE187.2_C3-TESTIS_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE187.2_C3-TESTIS_PRS-CS_MGI_20200608 187.2 Malignant neoplasm of testis Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative PRS-CS UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1061611 0.4 0.00899134 0.0861 0.531 0.468-0.594 OR 0 0-0 0 0-0 0.998 0.175-5.67 0.998 0.175-5.67 1.19 0.43-3.3 1.19 0.43-3.3 1.01 0.454-2.24 1.01 0.454-2.24 1.13 0.656-1.93 1.13 0.656-1.93 1.03 0.511-2.06 0.943 1.17 0.592-2.3 0.656 1.13 0.565-2.28 0.724 FALSE FALSE FALSE FALSE Male 73 682 GRCh37/hg19 auto 2020-06-08 prsweb-phecode187-2-20001-1045-lassosum-mgi-20200608 prsweb-phecode187-2-20001-1045-lassosum-mgi-20200608 PRSWEB_PHECODE187.2_20001-1045_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE187.2_20001-1045_LASSOSUM_MGI_20200608 187.2 Cancer code, self-reported: testicular cancer Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative lassosum UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 771 6.7e-05 0.0505392 0.084 0.656 0.593-0.717 OR 2.72 0.568-13.1 2.72 0.568-13.1 1.33 0.317-5.59 1.33 0.317-5.59 2.11 0.93-4.78 2.11 0.93-4.78 2.46 1.34-4.51 2.46 1.34-4.51 2.07 1.27-3.4 2.07 1.27-3.4 2.55 1.05-6.21 0.0389 3.02 1.25-7.28 0.0138 4.64 1.98-10.9 0.00042 TRUE FALSE FALSE TRUE Male 73 682 GRCh37/hg19 s=0.9;Lambda=0.07848 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000597/ScoringFiles/ phewas/PRSWEB_PHECODE187.2_20001-1045_LASSOSUM_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE187.2_20001-1045_LASSOSUM_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode187-2-c3-testis-lassosum-mgi-20200608 prsweb-phecode187-2-c3-testis-lassosum-mgi-20200608 PRSWEB_PHECODE187.2_C3-TESTIS_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE187.2_C3-TESTIS_LASSOSUM_MGI_20200608 187.2 Malignant neoplasm of testis Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative lassosum UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 250 0.00011 0.0530666 0.0839 0.636 0.565-0.698 OR 6.35 1.81-22.3 6.35 1.81-22.3 3.18 1.07-9.47 3.18 1.07-9.47 3.53 1.73-7.2 3.53 1.73-7.2 3.03 1.7-5.41 3.03 1.7-5.41 1.91 1.16-3.14 1.91 1.16-3.14 3.02 1.3-7.04 0.0105 2.42 1.03-5.73 0.0437 3.92 1.72-8.9 0.00113 TRUE FALSE FALSE TRUE Male 73 682 GRCh37/hg19 s=0.9;Lambda=0.1 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000600/ScoringFiles/ phewas/PRSWEB_PHECODE187.2_C3-TESTIS_LASSOSUM_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE187.2_C3-TESTIS_LASSOSUM_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode187-2-c62-lassosum-mgi-20200608 prsweb-phecode187-2-c62-lassosum-mgi-20200608 PRSWEB_PHECODE187.2_C62_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE187.2_C62_LASSOSUM_MGI_20200608 187.2 Diagnoses - main ICD10: C62 Malignant neoplasm of testis Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative lassosum UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 2944812 0.42 0.00411796 0.0861 0.527 0.461-0.599 OR 0 0-0 0 0-0 0.32 0.0177-5.77 0.32 0.0177-5.77 2.08 0.901-4.79 2.08 0.901-4.79 1.78 0.918-3.44 1.78 0.918-3.44 1.13 0.657-1.93 1.13 0.657-1.93 1.43 0.735-2.79 0.291 1.07 0.521-2.19 0.856 1.34 0.672-2.66 0.408 FALSE FALSE FALSE FALSE Male 73 682 GRCh37/hg19 s=0.2;Lambda=0.001 2020-06-08 prsweb-phecode187-2-gwas-catalog-r2019-05-03-x187-2-p-5e-05-ukb-20200608 prsweb-phecode187-2-gwas-catalog-r2019-05-03-x187-2-p-5e-05-ukb-20200608 PRSWEB_PHECODE187.2_GWAS-Catalog-r2019-05-03-X187.2_P_5e-05_UKB_20200608 P_5e-05 PRSWEB_PHECODE187.2_GWAS-Catalog-r2019-05-03-X187.2_P_5e-05_UKB_20200608 187.2 Testicular germ cell tumor;Testicular germ cell cancer Binary 51 unique SNPs UKB UK Biobank Fixed threshold (5e-05) GWAS Catalog (2019-05-03) 19483681;20543847;23666239;23666240;25877299;26503584;28604728;28604732 https://www.ncbi.nlm.nih.gov/pubmed/?term=19483681+20543847+23666239+23666240+25877299+26503584+28604728+28604732 46 5e-13 0.0504752 0.0794 0.697 0.652-0.74 OR 4.6 1.75-12.1 4.6 1.75-12.1 4.82 2.39-9.7 4.82 2.39-9.7 3.69 2.21-6.18 3.69 2.21-6.18 2.37 1.51-3.72 2.37 1.51-3.72 2.87 2.01-4.1 2.87 2.01-4.1 2.36 1.1-5.07 0.0278 4.45 2.19-9.08 3.93e-05 7.01 3.53-13.9 2.69e-08 TRUE FALSE FALSE FALSE Male 135 1349 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode187-2-gwas-catalog-r2019-05-03-x187-2-p-5e-06-ukb-20200608 prsweb-phecode187-2-gwas-catalog-r2019-05-03-x187-2-p-5e-06-ukb-20200608 PRSWEB_PHECODE187.2_GWAS-Catalog-r2019-05-03-X187.2_P_5e-06_UKB_20200608 P_5e-06 PRSWEB_PHECODE187.2_GWAS-Catalog-r2019-05-03-X187.2_P_5e-06_UKB_20200608 187.2 Testicular germ cell tumor;Testicular germ cell cancer Binary 51 unique SNPs UKB UK Biobank Fixed threshold (5e-06) GWAS Catalog (2019-05-03) 19483681;20543847;23666239;23666240;25877299;26503584;28604728;28604732 https://www.ncbi.nlm.nih.gov/pubmed/?term=19483681+20543847+23666239+23666240+25877299+26503584+28604728+28604732 44 1.3e-13 0.0526684 0.0793 0.703 0.659-0.745 OR 4.6 1.75-12.1 4.6 1.75-12.1 3.6 1.67-7.78 3.6 1.67-7.78 3.69 2.2-6.18 3.69 2.2-6.18 2.37 1.51-3.72 2.37 1.51-3.72 3.04 2.13-4.34 3.04 2.13-4.34 2.27 1.06-4.87 0.0344 4.2 2.06-8.58 8.08e-05 7.19 3.63-14.3 1.65e-08 TRUE FALSE FALSE FALSE Male 135 1349 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode187-2-gwas-catalog-r2019-05-03-x187-2-p-5e-07-ukb-20200608 prsweb-phecode187-2-gwas-catalog-r2019-05-03-x187-2-p-5e-07-ukb-20200608 PRSWEB_PHECODE187.2_GWAS-Catalog-r2019-05-03-X187.2_P_5e-07_UKB_20200608 P_5e-07 PRSWEB_PHECODE187.2_GWAS-Catalog-r2019-05-03-X187.2_P_5e-07_UKB_20200608 187.2 Testicular germ cell tumor;Testicular germ cell cancer Binary 51 unique SNPs UKB UK Biobank Fixed threshold (5e-07) GWAS Catalog (2019-05-03) 19483681;20543847;23666239;23666240;25877299;26503584;28604728;28604732 https://www.ncbi.nlm.nih.gov/pubmed/?term=19483681+20543847+23666239+23666240+25877299+26503584+28604728+28604732 42 3.9e-13 0.0515957 0.0795 0.699 0.656-0.742 OR 5.34 2.12-13.4 5.34 2.12-13.4 4.01 1.91-8.43 4.01 1.91-8.43 3.12 1.82-5.36 3.12 1.82-5.36 2.48 1.59-3.87 2.48 1.59-3.87 3.22 2.25-4.59 3.22 2.25-4.59 2.57 1.17-5.67 0.019 4.45 2.12-9.34 8.03e-05 8.24 4.03-16.9 8e-09 TRUE FALSE FALSE FALSE Male 135 1349 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode187-2-gwas-catalog-r2019-05-03-x187-2-p-5e-09-ukb-20200608 prsweb-phecode187-2-gwas-catalog-r2019-05-03-x187-2-p-5e-09-ukb-20200608 PRSWEB_PHECODE187.2_GWAS-Catalog-r2019-05-03-X187.2_P_5e-09_UKB_20200608 P_5e-09 PRSWEB_PHECODE187.2_GWAS-Catalog-r2019-05-03-X187.2_P_5e-09_UKB_20200608 187.2 Testicular germ cell tumor;Testicular germ cell cancer Binary 51 unique SNPs UKB UK Biobank Fixed threshold (5e-09) GWAS Catalog (2019-05-03) 19483681;20543847;23666239;23666240;25877299;26503584;28604728;28604732 https://www.ncbi.nlm.nih.gov/pubmed/?term=19483681+20543847+23666239+23666240+25877299+26503584+28604728+28604732 31 1.2e-11 0.0450324 0.08 0.681 0.634-0.723 OR 5.36 2.13-13.5 5.36 2.13-13.5 4.03 1.91-8.5 4.03 1.91-8.5 2.75 1.57-4.8 2.75 1.57-4.8 2.37 1.51-3.72 2.37 1.51-3.72 2.54 1.78-3.63 2.54 1.78-3.63 2.3 1.08-4.88 0.0305 4.58 2.27-9.24 2.23e-05 6.66 3.34-13.3 6.91e-08 TRUE FALSE FALSE FALSE Male 135 1349 GRCh37/hg19 P<=5e-09 2020-06-08 prsweb-phecode187-2-gwas-catalog-r2019-05-03-x187-2-p-5e-08-ukb-20200608 prsweb-phecode187-2-gwas-catalog-r2019-05-03-x187-2-p-5e-08-ukb-20200608 PRSWEB_PHECODE187.2_GWAS-Catalog-r2019-05-03-X187.2_P_5e-08_UKB_20200608 P_5e-08 PRSWEB_PHECODE187.2_GWAS-Catalog-r2019-05-03-X187.2_P_5e-08_UKB_20200608 187.2 Testicular germ cell tumor;Testicular germ cell cancer Binary 51 unique SNPs UKB UK Biobank GWAS Hits GWAS Catalog (2019-05-03) 19483681;20543847;23666239;23666240;25877299;26503584;28604728;28604732 https://www.ncbi.nlm.nih.gov/pubmed/?term=19483681+20543847+23666239+23666240+25877299+26503584+28604728+28604732 40 4.1e-13 0.0511444 0.0795 0.698 0.656-0.74 OR 4.6 1.75-12.1 4.6 1.75-12.1 3.6 1.67-7.77 3.6 1.67-7.77 3.31 1.95-5.63 3.31 1.95-5.63 2.7 1.75-4.18 2.7 1.75-4.18 3.22 2.25-4.61 3.22 2.25-4.61 3.03 1.34-6.87 0.00777 5.01 2.3-10.9 4.86e-05 9.43 4.42-20.1 6.12e-09 TRUE FALSE FALSE TRUE Male 135 1349 GRCh37/hg19 P<=5e-08 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000602/ScoringFiles/ phewas/PRSWEB_PHECODE187.2_GWAS-Catalog-r2019-05-03-X187.2_P_5e-08_UKB_20200608/all.tsv phewas/PRSWEB_PHECODE187.2_GWAS-Catalog-r2019-05-03-X187.2_P_5e-08_UKB_20200608/exclusion.tsv 2020-06-08 prsweb-phecode187-2-gwas-catalog-r2019-05-03-x187-2-pt-ukb-20200608 prsweb-phecode187-2-gwas-catalog-r2019-05-03-x187-2-pt-ukb-20200608 PRSWEB_PHECODE187.2_GWAS-Catalog-r2019-05-03-X187.2_PT_UKB_20200608 P&T PRSWEB_PHECODE187.2_GWAS-Catalog-r2019-05-03-X187.2_PT_UKB_20200608 187.2 Testicular germ cell tumor;Testicular germ cell cancer Binary 51 unique SNPs UKB UK Biobank P&T GWAS Catalog (2019-05-03) 19483681;20543847;23666239;23666240;25877299;26503584;28604728;28604732 https://www.ncbi.nlm.nih.gov/pubmed/?term=19483681+20543847+23666239+23666240+25877299+26503584+28604728+28604732 44 1.3e-13 0.0526684 0.0793 0.703 0.659-0.745 OR 4.6 1.75-12.1 4.6 1.75-12.1 3.6 1.67-7.78 3.6 1.67-7.78 3.69 2.2-6.18 3.69 2.2-6.18 2.37 1.51-3.72 2.37 1.51-3.72 3.04 2.13-4.34 3.04 2.13-4.34 2.27 1.06-4.87 0.0344 4.2 2.06-8.58 8.08e-05 7.19 3.63-14.3 1.65e-08 TRUE FALSE FALSE TRUE Male 135 1349 GRCh37/hg19 P<=5e-06 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000604/ScoringFiles/ phewas/PRSWEB_PHECODE187.2_GWAS-Catalog-r2019-05-03-X187.2_PT_UKB_20200608/all.tsv phewas/PRSWEB_PHECODE187.2_GWAS-Catalog-r2019-05-03-X187.2_PT_UKB_20200608/exclusion.tsv 2020-06-08 prsweb-phecode189-c3-urinary-tract-p-5e-05-mgi-20200608 prsweb-phecode189-c3-urinary-tract-p-5e-05-mgi-20200608 PRSWEB_PHECODE189_C3-URINARY-TRACT_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE189_C3-URINARY-TRACT_P_5e-05_MGI_20200608 189 Malignant neoplasm of urinary organs Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 122 0.26 0.000103933 0.0975 0.502 0.485-0.519 OR 1.23 0.712-2.11 1.23 0.712-2.11 0.896 0.576-1.39 0.896 0.576-1.39 1.14 0.879-1.47 1.14 0.879-1.47 1.11 0.916-1.33 1.11 0.916-1.33 1.09 0.955-1.25 1.09 0.955-1.25 1.12 0.946-1.32 0.192 0.989 0.835-1.17 0.9 1.13 0.957-1.33 0.15 FALSE FALSE FALSE FALSE Both 1276 10225 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode189-c3-urinary-tract-p-5e-06-mgi-20200608 prsweb-phecode189-c3-urinary-tract-p-5e-06-mgi-20200608 PRSWEB_PHECODE189_C3-URINARY-TRACT_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE189_C3-URINARY-TRACT_P_5e-06_MGI_20200608 189 Malignant neoplasm of urinary organs Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 12 0.019 0.000101778 0.0974 0.489 0.473-0.505 OR 1.41 0.845-2.37 1.41 0.845-2.37 1.43 0.994-2.06 1.43 0.994-2.06 1.38 1.09-1.75 1.38 1.09-1.75 1.08 0.893-1.31 1.08 0.893-1.31 1.09 0.951-1.24 1.09 0.951-1.24 1.02 0.859-1.2 0.852 1.09 0.925-1.29 0.3 1.12 0.948-1.32 0.184 TRUE FALSE FALSE FALSE Both 1276 10225 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode189-c3-urinary-tract-pt-mgi-20200608 prsweb-phecode189-c3-urinary-tract-pt-mgi-20200608 PRSWEB_PHECODE189_C3-URINARY-TRACT_PT_MGI_20200608 P&T PRSWEB_PHECODE189_C3-URINARY-TRACT_PT_MGI_20200608 189 Malignant neoplasm of urinary organs Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative P&T UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 77 0.23 0.000333183 0.0975 0.5 0.483-0.518 OR 0.992 0.558-1.77 0.992 0.558-1.77 1.09 0.732-1.63 1.09 0.732-1.63 1.2 0.935-1.54 1.2 0.935-1.54 1.1 0.911-1.33 1.1 0.911-1.33 1.03 0.904-1.18 1.03 0.904-1.18 1.09 0.923-1.29 0.312 1.07 0.901-1.26 0.458 1.09 0.924-1.29 0.302 FALSE FALSE FALSE FALSE Both 1276 10225 GRCh37/hg19 P<=2.51e-05 2020-06-08 prsweb-phecode189-c3-urinary-tract-prs-cs-mgi-20200608 prsweb-phecode189-c3-urinary-tract-prs-cs-mgi-20200608 PRSWEB_PHECODE189_C3-URINARY-TRACT_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE189_C3-URINARY-TRACT_PRS-CS_MGI_20200608 189 Malignant neoplasm of urinary organs Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative PRS-CS UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1109848 0.063 9.02388e-05 0.0975 0.513 0.498-0.53 OR 1.14 0.653-1.99 1.14 0.653-1.99 0.963 0.629-1.47 0.963 0.629-1.47 1.17 0.904-1.5 1.17 0.904-1.5 1.12 0.924-1.35 1.12 0.924-1.35 1 0.877-1.15 1 0.877-1.15 1.09 0.917-1.29 0.339 1.21 1.02-1.42 0.0268 1.1 0.931-1.3 0.26 FALSE FALSE FALSE FALSE Both 1276 10225 GRCh37/hg19 auto 2020-06-08 prsweb-phecode189-1-ukbb-saige-hrc-x189-1-p-5e-05-mgi-20200608 prsweb-phecode189-1-ukbb-saige-hrc-x189-1-p-5e-05-mgi-20200608 PRSWEB_PHECODE189.1_UKBB-SAIGE-HRC-X189.1_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE189.1_UKBB-SAIGE-HRC-X189.1_P_5e-05_MGI_20200608 189.1 Cancer of kidney and renal pelvis Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 83 0.82 0.000319841 0.0827 0.495 0.473-0.517 OR 0.868 0.36-2.09 0.868 0.36-2.09 0.915 0.497-1.69 0.915 0.497-1.69 0.874 0.586-1.3 0.874 0.586-1.3 0.807 0.6-1.09 0.807 0.6-1.09 1.06 0.882-1.28 1.06 0.882-1.28 1.04 0.824-1.31 0.749 0.97 0.766-1.23 0.798 1.06 0.843-1.34 0.611 FALSE FALSE FALSE FALSE Both 625 6237 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode189-1-ukbb-saige-hrc-x189-1-p-5e-06-mgi-20200608 prsweb-phecode189-1-ukbb-saige-hrc-x189-1-p-5e-06-mgi-20200608 PRSWEB_PHECODE189.1_UKBB-SAIGE-HRC-X189.1_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE189.1_UKBB-SAIGE-HRC-X189.1_P_5e-06_MGI_20200608 189.1 Cancer of kidney and renal pelvis Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 9 0.17 1.51832e-05 0.0827 0.488 0.464-0.512 OR 1.84 0.973-3.49 1.84 0.973-3.49 1.83 1.16-2.89 1.83 1.16-2.89 1.46 1.05-2.02 1.46 1.05-2.02 1.2 0.929-1.55 1.2 0.929-1.55 1.11 0.924-1.34 1.11 0.924-1.34 1.05 0.832-1.33 0.674 1.03 0.817-1.31 0.777 1.14 0.906-1.44 0.263 FALSE FALSE FALSE FALSE Both 625 6237 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode189-1-ukbb-saige-hrc-x189-1-pt-mgi-20200608 prsweb-phecode189-1-ukbb-saige-hrc-x189-1-pt-mgi-20200608 PRSWEB_PHECODE189.1_UKBB-SAIGE-HRC-X189.1_PT_MGI_20200608 P&T PRSWEB_PHECODE189.1_UKBB-SAIGE-HRC-X189.1_PT_MGI_20200608 189.1 Cancer of kidney and renal pelvis Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative P&T UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 162 0.58 0.000431957 0.0827 0.501 0.478-0.523 OR 1.04 0.461-2.36 1.04 0.461-2.36 1.08 0.611-1.91 1.08 0.611-1.91 0.91 0.615-1.35 0.91 0.615-1.35 1.07 0.819-1.4 1.07 0.819-1.4 0.984 0.813-1.19 0.984 0.813-1.19 0.98 0.774-1.24 0.866 1.13 0.902-1.43 0.281 1.02 0.805-1.29 0.884 FALSE FALSE FALSE FALSE Both 625 6237 GRCh37/hg19 P<=9.86e-05 2020-06-08 prsweb-phecode189-1-ukbb-saige-hrc-x189-1-prs-cs-mgi-20200608 prsweb-phecode189-1-ukbb-saige-hrc-x189-1-prs-cs-mgi-20200608 PRSWEB_PHECODE189.1_UKBB-SAIGE-HRC-X189.1_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE189.1_UKBB-SAIGE-HRC-X189.1_PRS-CS_MGI_20200608 189.1 Cancer of kidney and renal pelvis Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative PRS-CS UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1119238 0.72 0.000197021 0.0827 0.503 0.479-0.526 OR 0.692 0.264-1.82 0.692 0.264-1.82 0.983 0.545-1.77 0.983 0.545-1.77 1.06 0.738-1.54 1.06 0.738-1.54 1.04 0.798-1.37 1.04 0.798-1.37 1.05 0.867-1.26 1.05 0.867-1.26 0.911 0.721-1.15 0.435 0.954 0.757-1.2 0.691 0.983 0.781-1.24 0.882 FALSE FALSE FALSE FALSE Both 625 6237 GRCh37/hg19 auto 2020-06-08 prsweb-phecode189-11-c3-kidney-notrenalpelvis-p-5e-05-mgi-20200608 prsweb-phecode189-11-c3-kidney-notrenalpelvis-p-5e-05-mgi-20200608 PRSWEB_PHECODE189.11_C3-KIDNEY-NOTRENALPELVIS_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE189.11_C3-KIDNEY-NOTRENALPELVIS_P_5e-05_MGI_20200608 189.11 Malignant neoplasm of kidney, except renal pelvis Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 132 0.28 1.80826e-07 0.0827 0.511 0.485-0.536 OR 1.03 0.425-2.51 1.03 0.425-2.51 0.97 0.511-1.84 0.97 0.511-1.84 0.907 0.594-1.39 0.907 0.594-1.39 1.01 0.755-1.36 1.01 0.755-1.36 1.12 0.92-1.37 1.12 0.92-1.37 0.938 0.723-1.22 0.627 1.11 0.863-1.42 0.421 1.14 0.887-1.46 0.312 FALSE FALSE FALSE FALSE Both 536 5353 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode189-11-gwas-catalog-r2019-05-03-x189-11-p-5e-05-mgi-20200608 prsweb-phecode189-11-gwas-catalog-r2019-05-03-x189-11-p-5e-05-mgi-20200608 PRSWEB_PHECODE189.11_GWAS-Catalog-r2019-05-03-X189.11_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE189.11_GWAS-Catalog-r2019-05-03-X189.11_P_5e-05_MGI_20200608 189.11 Renal cell carcinoma;Wilms tumor Binary 15 unique SNPs MGI Michigan Genomics Initiative Fixed threshold (5e-05) GWAS Catalog (2019-05-03) 22544364;28598434 https://www.ncbi.nlm.nih.gov/pubmed/?term=22544364+28598434 13 0.17 0.000695805 0.0827 0.492 0.466-0.516 OR 1.78 0.882-3.59 1.78 0.882-3.59 1.15 0.634-2.08 1.15 0.634-2.08 1.49 1.06-2.11 1.49 1.06-2.11 1.24 0.946-1.64 1.24 0.946-1.64 1.06 0.864-1.29 1.06 0.864-1.29 1.11 0.863-1.43 0.415 1.06 0.821-1.37 0.651 1.12 0.872-1.45 0.368 FALSE FALSE FALSE FALSE Both 536 5353 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode189-11-ukbb-saige-hrc-x189-11-p-5e-05-mgi-20200608 prsweb-phecode189-11-ukbb-saige-hrc-x189-11-p-5e-05-mgi-20200608 PRSWEB_PHECODE189.11_UKBB-SAIGE-HRC-X189.11_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE189.11_UKBB-SAIGE-HRC-X189.11_P_5e-05_MGI_20200608 189.11 Malignant neoplasm of kidney, except pelvis Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 81 0.11 4.18219e-05 0.0827 0.508 0.481-0.533 OR 1.74 0.864-3.5 1.74 0.864-3.5 1.53 0.905-2.6 1.53 0.905-2.6 1.18 0.805-1.72 1.18 0.805-1.72 1.2 0.911-1.58 1.2 0.911-1.58 1.17 0.958-1.42 1.17 0.958-1.42 1.17 0.905-1.51 0.232 1.1 0.846-1.42 0.482 1.27 0.984-1.63 0.067 FALSE FALSE FALSE FALSE Both 536 5353 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode189-11-20001-1034-p-5e-06-mgi-20200608 prsweb-phecode189-11-20001-1034-p-5e-06-mgi-20200608 PRSWEB_PHECODE189.11_20001-1034_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE189.11_20001-1034_P_5e-06_MGI_20200608 189.11 Cancer code, self-reported: kidney/renal cell cancer Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 13 0.36 0.000173975 0.0827 0.491 0.466-0.518 OR 2.32 1.24-4.33 2.32 1.24-4.33 1.62 0.97-2.72 1.62 0.97-2.72 1.59 1.13-2.24 1.59 1.13-2.24 1.23 0.931-1.61 1.23 0.931-1.61 0.981 0.798-1.2 0.981 0.798-1.2 1.03 0.805-1.32 0.811 0.943 0.733-1.21 0.645 0.966 0.752-1.24 0.787 FALSE FALSE FALSE FALSE Both 536 5353 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode189-11-c3-kidney-notrenalpelvis-p-5e-06-mgi-20200608 prsweb-phecode189-11-c3-kidney-notrenalpelvis-p-5e-06-mgi-20200608 PRSWEB_PHECODE189.11_C3-KIDNEY-NOTRENALPELVIS_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE189.11_C3-KIDNEY-NOTRENALPELVIS_P_5e-06_MGI_20200608 189.11 Malignant neoplasm of kidney, except renal pelvis Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 21 0.75 8.722e-05 0.0827 0.494 0.471-0.519 OR 1.4 0.645-3.03 1.4 0.645-3.03 0.967 0.509-1.84 0.967 0.509-1.84 1.07 0.717-1.59 1.07 0.717-1.59 1.02 0.758-1.36 1.02 0.758-1.36 0.961 0.782-1.18 0.961 0.782-1.18 1.07 0.831-1.38 0.596 1.15 0.892-1.47 0.286 1.03 0.8-1.33 0.805 FALSE FALSE FALSE FALSE Both 536 5353 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode189-11-c64-p-5e-06-mgi-20200608 prsweb-phecode189-11-c64-p-5e-06-mgi-20200608 PRSWEB_PHECODE189.11_C64_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE189.11_C64_P_5e-06_MGI_20200608 189.11 Diagnoses - main ICD10: C64 Malignant neoplasm of kidney, except renal pelvis Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 24 0.89 0.000274342 0.0827 0.486 0.462-0.515 OR 1.56 0.75-3.25 1.56 0.75-3.25 1.34 0.765-2.33 1.34 0.765-2.33 1.06 0.713-1.58 1.06 0.713-1.58 1.01 0.754-1.36 1.01 0.754-1.36 1.08 0.879-1.32 1.08 0.879-1.32 1.17 0.912-1.5 0.215 0.993 0.766-1.29 0.955 1.12 0.87-1.44 0.378 FALSE FALSE FALSE FALSE Both 536 5353 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode189-11-gwas-catalog-r2019-05-03-x189-11-p-5e-06-mgi-20200608 prsweb-phecode189-11-gwas-catalog-r2019-05-03-x189-11-p-5e-06-mgi-20200608 PRSWEB_PHECODE189.11_GWAS-Catalog-r2019-05-03-X189.11_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE189.11_GWAS-Catalog-r2019-05-03-X189.11_P_5e-06_MGI_20200608 189.11 Renal cell carcinoma;Wilms tumor Binary 15 unique SNPs MGI Michigan Genomics Initiative Fixed threshold (5e-06) GWAS Catalog (2019-05-03) 22544364;28598434 https://www.ncbi.nlm.nih.gov/pubmed/?term=22544364+28598434 13 0.17 0.000695805 0.0827 0.492 0.466-0.516 OR 1.78 0.882-3.59 1.78 0.882-3.59 1.15 0.634-2.08 1.15 0.634-2.08 1.49 1.06-2.11 1.49 1.06-2.11 1.24 0.946-1.64 1.24 0.946-1.64 1.06 0.864-1.29 1.06 0.864-1.29 1.11 0.863-1.43 0.415 1.06 0.821-1.37 0.651 1.12 0.872-1.45 0.368 FALSE FALSE FALSE FALSE Both 536 5353 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode189-11-ukbb-saige-hrc-x189-11-p-5e-06-mgi-20200608 prsweb-phecode189-11-ukbb-saige-hrc-x189-11-p-5e-06-mgi-20200608 PRSWEB_PHECODE189.11_UKBB-SAIGE-HRC-X189.11_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE189.11_UKBB-SAIGE-HRC-X189.11_P_5e-06_MGI_20200608 189.11 Malignant neoplasm of kidney, except pelvis Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 13 0.23 0.000891007 0.0827 0.489 0.463-0.513 OR 1.01 0.417-2.46 1.01 0.417-2.46 1.45 0.845-2.5 1.45 0.845-2.5 1.55 1.1-2.18 1.55 1.1-2.18 1.27 0.971-1.67 1.27 0.971-1.67 1.05 0.861-1.29 1.05 0.861-1.29 0.851 0.656-1.11 0.227 1.15 0.902-1.47 0.259 1.06 0.825-1.36 0.659 FALSE FALSE FALSE FALSE Both 536 5353 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode189-11-gwas-catalog-r2019-05-03-x189-11-p-5e-07-mgi-20200608 prsweb-phecode189-11-gwas-catalog-r2019-05-03-x189-11-p-5e-07-mgi-20200608 PRSWEB_PHECODE189.11_GWAS-Catalog-r2019-05-03-X189.11_P_5e-07_MGI_20200608 P_5e-07 PRSWEB_PHECODE189.11_GWAS-Catalog-r2019-05-03-X189.11_P_5e-07_MGI_20200608 189.11 Renal cell carcinoma;Wilms tumor Binary 15 unique SNPs MGI Michigan Genomics Initiative Fixed threshold (5e-07) GWAS Catalog (2019-05-03) 22544364;28598434 https://www.ncbi.nlm.nih.gov/pubmed/?term=22544364+28598434 13 0.17 0.000695805 0.0827 0.492 0.466-0.516 OR 1.78 0.882-3.59 1.78 0.882-3.59 1.15 0.634-2.08 1.15 0.634-2.08 1.49 1.06-2.11 1.49 1.06-2.11 1.24 0.946-1.64 1.24 0.946-1.64 1.06 0.864-1.29 1.06 0.864-1.29 1.11 0.863-1.43 0.415 1.06 0.821-1.37 0.651 1.12 0.872-1.45 0.368 FALSE FALSE FALSE FALSE Both 536 5353 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode189-11-gwas-catalog-r2019-05-03-x189-11-p-5e-09-mgi-20200608 prsweb-phecode189-11-gwas-catalog-r2019-05-03-x189-11-p-5e-09-mgi-20200608 PRSWEB_PHECODE189.11_GWAS-Catalog-r2019-05-03-X189.11_P_5e-09_MGI_20200608 P_5e-09 PRSWEB_PHECODE189.11_GWAS-Catalog-r2019-05-03-X189.11_P_5e-09_MGI_20200608 189.11 Renal cell carcinoma;Wilms tumor Binary 15 unique SNPs MGI Michigan Genomics Initiative Fixed threshold (5e-09) GWAS Catalog (2019-05-03) 22544364;28598434 https://www.ncbi.nlm.nih.gov/pubmed/?term=22544364+28598434 8 0.2 0.000357801 0.0827 0.489 0.464-0.514 OR 1.57 0.752-3.27 1.57 0.752-3.27 1.44 0.835-2.47 1.44 0.835-2.47 1.33 0.927-1.91 1.33 0.927-1.91 1.22 0.927-1.61 1.22 0.927-1.61 1.11 0.906-1.35 1.11 0.906-1.35 0.998 0.772-1.29 0.988 0.986 0.762-1.28 0.914 1.1 0.851-1.41 0.475 FALSE FALSE FALSE FALSE Both 536 5353 GRCh37/hg19 P<=5e-09 2020-06-08 prsweb-phecode189-11-gwas-catalog-r2019-05-03-x189-11-p-5e-08-mgi-20200608 prsweb-phecode189-11-gwas-catalog-r2019-05-03-x189-11-p-5e-08-mgi-20200608 PRSWEB_PHECODE189.11_GWAS-Catalog-r2019-05-03-X189.11_P_5e-08_MGI_20200608 P_5e-08 PRSWEB_PHECODE189.11_GWAS-Catalog-r2019-05-03-X189.11_P_5e-08_MGI_20200608 189.11 Renal cell carcinoma;Wilms tumor Binary 15 unique SNPs MGI Michigan Genomics Initiative GWAS Hits GWAS Catalog (2019-05-03) 22544364;28598434 https://www.ncbi.nlm.nih.gov/pubmed/?term=22544364+28598434 12 0.15 0.000756919 0.0827 0.493 0.467-0.517 OR 1.58 0.758-3.3 1.58 0.758-3.3 1.43 0.834-2.47 1.43 0.834-2.47 1.45 1.02-2.06 1.45 1.02-2.06 1.18 0.89-1.55 1.18 0.89-1.55 1.07 0.873-1.31 1.07 0.873-1.31 1.14 0.881-1.47 0.324 1.11 0.859-1.44 0.422 1.16 0.903-1.5 0.239 FALSE FALSE FALSE FALSE Both 536 5353 GRCh37/hg19 P<=5e-08 2020-06-08 prsweb-phecode189-11-20001-1034-pt-mgi-20200608 prsweb-phecode189-11-20001-1034-pt-mgi-20200608 PRSWEB_PHECODE189.11_20001-1034_PT_MGI_20200608 P&T PRSWEB_PHECODE189.11_20001-1034_PT_MGI_20200608 189.11 Cancer code, self-reported: kidney/renal cell cancer Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative P&T UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 17 0.27 0.000290807 0.0827 0.496 0.471-0.523 OR 1.74 0.863-3.5 1.74 0.863-3.5 1.24 0.7-2.21 1.24 0.7-2.21 1.38 0.967-1.98 1.38 0.967-1.98 1.32 1.01-1.72 1.32 1.01-1.72 1.09 0.894-1.34 1.09 0.894-1.34 1.38 1.07-1.78 0.0125 1.11 0.854-1.45 0.431 1.26 0.972-1.62 0.0814 FALSE FALSE FALSE FALSE Both 536 5353 GRCh37/hg19 P<=7.94e-06 2020-06-08 prsweb-phecode189-11-c3-kidney-notrenalpelvis-pt-mgi-20200608 prsweb-phecode189-11-c3-kidney-notrenalpelvis-pt-mgi-20200608 PRSWEB_PHECODE189.11_C3-KIDNEY-NOTRENALPELVIS_PT_MGI_20200608 P&T PRSWEB_PHECODE189.11_C3-KIDNEY-NOTRENALPELVIS_PT_MGI_20200608 189.11 Malignant neoplasm of kidney, except renal pelvis Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative P&T UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 11 0.71 0.000505883 0.0827 0.486 0.463-0.511 OR 0.46 0.128-1.65 0.46 0.128-1.65 1.26 0.707-2.23 1.26 0.707-2.23 0.981 0.652-1.48 0.981 0.652-1.48 1.08 0.808-1.44 1.08 0.808-1.44 1.03 0.837-1.26 1.03 0.837-1.26 0.99 0.769-1.27 0.94 1.03 0.802-1.32 0.817 1.04 0.808-1.33 0.771 FALSE FALSE FALSE FALSE Both 536 5353 GRCh37/hg19 P<=2.51e-06 2020-06-08 prsweb-phecode189-11-c64-pt-mgi-20200608 prsweb-phecode189-11-c64-pt-mgi-20200608 PRSWEB_PHECODE189.11_C64_PT_MGI_20200608 P&T PRSWEB_PHECODE189.11_C64_PT_MGI_20200608 189.11 Diagnoses - main ICD10: C64 Malignant neoplasm of kidney, except renal pelvis Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative P&T UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 24 0.89 0.000274342 0.0827 0.486 0.462-0.515 OR 1.56 0.75-3.25 1.56 0.75-3.25 1.34 0.765-2.33 1.34 0.765-2.33 1.06 0.713-1.58 1.06 0.713-1.58 1.01 0.754-1.36 1.01 0.754-1.36 1.08 0.879-1.32 1.08 0.879-1.32 1.17 0.912-1.5 0.215 0.993 0.766-1.29 0.955 1.12 0.87-1.44 0.378 FALSE FALSE FALSE FALSE Both 536 5353 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode189-11-gwas-catalog-r2019-05-03-x189-11-pt-mgi-20200608 prsweb-phecode189-11-gwas-catalog-r2019-05-03-x189-11-pt-mgi-20200608 PRSWEB_PHECODE189.11_GWAS-Catalog-r2019-05-03-X189.11_PT_MGI_20200608 P&T PRSWEB_PHECODE189.11_GWAS-Catalog-r2019-05-03-X189.11_PT_MGI_20200608 189.11 Renal cell carcinoma;Wilms tumor Binary 15 unique SNPs MGI Michigan Genomics Initiative P&T GWAS Catalog (2019-05-03) 22544364;28598434 https://www.ncbi.nlm.nih.gov/pubmed/?term=22544364+28598434 12 0.15 0.000756919 0.0827 0.493 0.467-0.517 OR 1.58 0.758-3.3 1.58 0.758-3.3 1.43 0.834-2.47 1.43 0.834-2.47 1.45 1.02-2.06 1.45 1.02-2.06 1.18 0.89-1.55 1.18 0.89-1.55 1.07 0.873-1.31 1.07 0.873-1.31 1.14 0.881-1.47 0.324 1.11 0.859-1.44 0.422 1.16 0.903-1.5 0.239 FALSE FALSE FALSE FALSE Both 536 5353 GRCh37/hg19 P<=5e-08 2020-06-08 prsweb-phecode189-11-ukbb-saige-hrc-x189-11-pt-mgi-20200608 prsweb-phecode189-11-ukbb-saige-hrc-x189-11-pt-mgi-20200608 PRSWEB_PHECODE189.11_UKBB-SAIGE-HRC-X189.11_PT_MGI_20200608 P&T PRSWEB_PHECODE189.11_UKBB-SAIGE-HRC-X189.11_PT_MGI_20200608 189.11 Malignant neoplasm of kidney, except pelvis Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative P&T UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 11 0.097 0.00127437 0.0827 0.495 0.47-0.518 OR 1.95 0.998-3.82 1.95 0.998-3.82 1.72 1.04-2.85 1.72 1.04-2.85 1.34 0.934-1.93 1.34 0.934-1.93 1.18 0.897-1.56 1.18 0.897-1.56 1.04 0.851-1.28 1.04 0.851-1.28 0.92 0.71-1.19 0.527 1.16 0.909-1.49 0.23 1.07 0.834-1.38 0.588 FALSE FALSE FALSE FALSE Both 536 5353 GRCh37/hg19 P<=3.98e-06 2020-06-08 prsweb-phecode189-11-20001-1034-prs-cs-mgi-20200608 prsweb-phecode189-11-20001-1034-prs-cs-mgi-20200608 PRSWEB_PHECODE189.11_20001-1034_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE189.11_20001-1034_PRS-CS_MGI_20200608 189.11 Cancer code, self-reported: kidney/renal cell cancer Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative PRS-CS UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1067434 0.19 0.000976903 0.0827 0.513 0.487-0.542 OR 1.58 0.757-3.28 1.58 0.757-3.28 1.53 0.903-2.59 1.53 0.903-2.59 1.42 0.996-2.02 1.42 0.996-2.02 1.4 1.08-1.82 1.4 1.08-1.82 1.18 0.972-1.44 1.18 0.972-1.44 1.04 0.809-1.33 0.765 0.875 0.674-1.13 0.313 1.14 0.894-1.46 0.29 FALSE FALSE FALSE FALSE Both 536 5353 GRCh37/hg19 auto 2020-06-08 prsweb-phecode189-11-c3-kidney-notrenalpelvis-prs-cs-mgi-20200608 prsweb-phecode189-11-c3-kidney-notrenalpelvis-prs-cs-mgi-20200608 PRSWEB_PHECODE189.11_C3-KIDNEY-NOTRENALPELVIS_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE189.11_C3-KIDNEY-NOTRENALPELVIS_PRS-CS_MGI_20200608 189.11 Malignant neoplasm of kidney, except renal pelvis Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative PRS-CS UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1096344 0.054 1.63935e-05 0.0826 0.525 0.502-0.549 OR 1.56 0.751-3.26 1.56 0.751-3.26 1.05 0.569-1.95 1.05 0.569-1.95 0.98 0.651-1.48 0.98 0.651-1.48 0.954 0.706-1.29 0.954 0.706-1.29 1.08 0.885-1.32 1.08 0.885-1.32 1.18 0.905-1.53 0.225 1.33 1.03-1.72 0.029 1.27 0.981-1.64 0.0697 FALSE FALSE FALSE FALSE Both 536 5353 GRCh37/hg19 auto 2020-06-08 prsweb-phecode189-11-c64-prs-cs-mgi-20200608 prsweb-phecode189-11-c64-prs-cs-mgi-20200608 PRSWEB_PHECODE189.11_C64_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE189.11_C64_PRS-CS_MGI_20200608 189.11 Diagnoses - main ICD10: C64 Malignant neoplasm of kidney, except renal pelvis Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative PRS-CS UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1092593 0.33 5.84998e-05 0.0827 0.514 0.489-0.538 OR 1.58 0.76-3.3 1.58 0.76-3.3 1.35 0.772-2.35 1.35 0.772-2.35 0.904 0.592-1.38 0.904 0.592-1.38 0.969 0.719-1.31 0.969 0.719-1.31 0.998 0.813-1.22 0.998 0.813-1.22 0.901 0.694-1.17 0.436 1.24 0.971-1.58 0.085 1.03 0.803-1.33 0.797 FALSE FALSE FALSE FALSE Both 536 5353 GRCh37/hg19 auto 2020-06-08 prsweb-phecode189-11-ukbb-saige-hrc-x189-11-prs-cs-mgi-20200608 prsweb-phecode189-11-ukbb-saige-hrc-x189-11-prs-cs-mgi-20200608 PRSWEB_PHECODE189.11_UKBB-SAIGE-HRC-X189.11_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE189.11_UKBB-SAIGE-HRC-X189.11_PRS-CS_MGI_20200608 189.11 Malignant neoplasm of kidney, except pelvis Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative PRS-CS UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1119238 0.22 1.08162e-05 0.0827 0.515 0.489-0.536 OR 1.18 0.518-2.69 1.18 0.518-2.69 1.53 0.902-2.59 1.53 0.902-2.59 1.34 0.933-1.93 1.34 0.933-1.93 1.14 0.86-1.51 1.14 0.86-1.51 0.951 0.773-1.17 0.951 0.773-1.17 1.01 0.777-1.31 0.94 1.38 1.08-1.77 0.00957 1.07 0.826-1.39 0.607 FALSE FALSE FALSE FALSE Both 536 5353 GRCh37/hg19 auto 2020-06-08 prsweb-phecode189-11-20001-1034-lassosum-mgi-20200608 prsweb-phecode189-11-20001-1034-lassosum-mgi-20200608 PRSWEB_PHECODE189.11_20001-1034_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE189.11_20001-1034_LASSOSUM_MGI_20200608 189.11 Cancer code, self-reported: kidney/renal cell cancer Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative lassosum UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 4720259 0.16 0.00101437 0.0827 0.512 0.486-0.538 OR 1.2 0.528-2.75 1.2 0.528-2.75 1.36 0.777-2.37 1.36 0.777-2.37 1.81 1.31-2.5 1.81 1.31-2.5 1.36 1.04-1.78 1.36 1.04-1.78 1.18 0.967-1.44 1.18 0.967-1.44 1.08 0.843-1.39 0.534 0.889 0.684-1.15 0.376 1.16 0.91-1.49 0.228 FALSE FALSE FALSE FALSE Both 536 5353 GRCh37/hg19 s=1;Lambda=0.001 2020-06-08 prsweb-phecode189-11-c3-kidney-notrenalpelvis-lassosum-mgi-20200608 prsweb-phecode189-11-c3-kidney-notrenalpelvis-lassosum-mgi-20200608 PRSWEB_PHECODE189.11_C3-KIDNEY-NOTRENALPELVIS_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE189.11_C3-KIDNEY-NOTRENALPELVIS_LASSOSUM_MGI_20200608 189.11 Malignant neoplasm of kidney, except renal pelvis Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative lassosum UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 37 0.83 0.00116802 0.0827 0.503 0.482-0.53 OR 1.17 0.515-2.68 1.17 0.515-2.68 1.23 0.689-2.18 1.23 0.689-2.18 0.892 0.583-1.36 0.892 0.583-1.36 1.01 0.75-1.35 1.01 0.75-1.35 1.04 0.845-1.27 1.04 0.845-1.27 1.07 0.827-1.38 0.608 1.19 0.928-1.53 0.168 1.12 0.867-1.44 0.392 FALSE FALSE FALSE FALSE Both 536 5353 GRCh37/hg19 s=1;Lambda=0.07848 2020-06-08 prsweb-phecode189-11-gwas-catalog-r2019-05-03-x189-11-p-5e-05-ukb-20200608 prsweb-phecode189-11-gwas-catalog-r2019-05-03-x189-11-p-5e-05-ukb-20200608 PRSWEB_PHECODE189.11_GWAS-Catalog-r2019-05-03-X189.11_P_5e-05_UKB_20200608 P_5e-05 PRSWEB_PHECODE189.11_GWAS-Catalog-r2019-05-03-X189.11_P_5e-05_UKB_20200608 189.11 Renal cell carcinoma;Wilms tumor Binary 15 unique SNPs UKB UK Biobank Fixed threshold (5e-05) GWAS Catalog (2019-05-03) 22544364;28598434 https://www.ncbi.nlm.nih.gov/pubmed/?term=22544364+28598434 13 0.0032 0.000538324 0.0825 0.511 0.486-0.535 OR 2.17 1.13-4.14 2.17 1.13-4.14 1.56 0.921-2.65 1.56 0.921-2.65 1.36 0.945-1.95 1.36 0.945-1.95 1.38 1.06-1.8 1.38 1.06-1.8 1.28 1.05-1.56 1.28 1.05-1.56 1.14 0.881-1.48 0.315 1.05 0.807-1.37 0.716 1.37 1.07-1.76 0.0136 TRUE FALSE FALSE FALSE Both 529 5289 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode189-11-gwas-catalog-r2019-05-03-x189-11-p-5e-06-ukb-20200608 prsweb-phecode189-11-gwas-catalog-r2019-05-03-x189-11-p-5e-06-ukb-20200608 PRSWEB_PHECODE189.11_GWAS-Catalog-r2019-05-03-X189.11_P_5e-06_UKB_20200608 P_5e-06 PRSWEB_PHECODE189.11_GWAS-Catalog-r2019-05-03-X189.11_P_5e-06_UKB_20200608 189.11 Renal cell carcinoma;Wilms tumor Binary 15 unique SNPs UKB UK Biobank Fixed threshold (5e-06) GWAS Catalog (2019-05-03) 22544364;28598434 https://www.ncbi.nlm.nih.gov/pubmed/?term=22544364+28598434 13 0.0032 0.000538324 0.0825 0.511 0.486-0.535 OR 2.17 1.13-4.14 2.17 1.13-4.14 1.56 0.921-2.65 1.56 0.921-2.65 1.36 0.945-1.95 1.36 0.945-1.95 1.38 1.06-1.8 1.38 1.06-1.8 1.28 1.05-1.56 1.28 1.05-1.56 1.14 0.881-1.48 0.315 1.05 0.807-1.37 0.716 1.37 1.07-1.76 0.0136 TRUE FALSE FALSE FALSE Both 529 5289 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode189-11-gwas-catalog-r2019-05-03-x189-11-p-5e-07-ukb-20200608 prsweb-phecode189-11-gwas-catalog-r2019-05-03-x189-11-p-5e-07-ukb-20200608 PRSWEB_PHECODE189.11_GWAS-Catalog-r2019-05-03-X189.11_P_5e-07_UKB_20200608 P_5e-07 PRSWEB_PHECODE189.11_GWAS-Catalog-r2019-05-03-X189.11_P_5e-07_UKB_20200608 189.11 Renal cell carcinoma;Wilms tumor Binary 15 unique SNPs UKB UK Biobank Fixed threshold (5e-07) GWAS Catalog (2019-05-03) 22544364;28598434 https://www.ncbi.nlm.nih.gov/pubmed/?term=22544364+28598434 13 0.0032 0.000538324 0.0825 0.511 0.486-0.535 OR 2.17 1.13-4.14 2.17 1.13-4.14 1.56 0.921-2.65 1.56 0.921-2.65 1.36 0.945-1.95 1.36 0.945-1.95 1.38 1.06-1.8 1.38 1.06-1.8 1.28 1.05-1.56 1.28 1.05-1.56 1.14 0.881-1.48 0.315 1.05 0.807-1.37 0.716 1.37 1.07-1.76 0.0136 TRUE FALSE FALSE FALSE Both 529 5289 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode189-11-gwas-catalog-r2019-05-03-x189-11-p-5e-09-ukb-20200608 prsweb-phecode189-11-gwas-catalog-r2019-05-03-x189-11-p-5e-09-ukb-20200608 PRSWEB_PHECODE189.11_GWAS-Catalog-r2019-05-03-X189.11_P_5e-09_UKB_20200608 P_5e-09 PRSWEB_PHECODE189.11_GWAS-Catalog-r2019-05-03-X189.11_P_5e-09_UKB_20200608 189.11 Renal cell carcinoma;Wilms tumor Binary 15 unique SNPs UKB UK Biobank Fixed threshold (5e-09) GWAS Catalog (2019-05-03) 22544364;28598434 https://www.ncbi.nlm.nih.gov/pubmed/?term=22544364+28598434 8 0.0017 3.12774e-05 0.0825 0.513 0.49-0.537 OR 2.36 1.26-4.41 2.36 1.26-4.41 1.74 1.05-2.88 1.74 1.05-2.88 1.19 0.81-1.74 1.19 0.81-1.74 1.11 0.835-1.48 1.11 0.835-1.48 1.33 1.1-1.61 1.33 1.1-1.61 1.18 0.914-1.53 0.201 1.07 0.816-1.41 0.619 1.41 1.1-1.82 0.00748 TRUE FALSE FALSE FALSE Both 529 5289 GRCh37/hg19 P<=5e-09 2020-06-08 prsweb-phecode189-11-gwas-catalog-r2019-05-03-x189-11-p-5e-08-ukb-20200608 prsweb-phecode189-11-gwas-catalog-r2019-05-03-x189-11-p-5e-08-ukb-20200608 PRSWEB_PHECODE189.11_GWAS-Catalog-r2019-05-03-X189.11_P_5e-08_UKB_20200608 P_5e-08 PRSWEB_PHECODE189.11_GWAS-Catalog-r2019-05-03-X189.11_P_5e-08_UKB_20200608 189.11 Renal cell carcinoma;Wilms tumor Binary 15 unique SNPs UKB UK Biobank GWAS Hits GWAS Catalog (2019-05-03) 22544364;28598434 https://www.ncbi.nlm.nih.gov/pubmed/?term=22544364+28598434 12 0.00077 0.000683427 0.0825 0.517 0.492-0.54 OR 2.17 1.13-4.14 2.17 1.13-4.14 1.86 1.13-3.04 1.86 1.13-3.04 1.28 0.88-1.85 1.28 0.88-1.85 1.29 0.979-1.69 1.29 0.979-1.69 1.31 1.08-1.6 1.31 1.08-1.6 1.13 0.871-1.47 0.356 1.06 0.811-1.38 0.685 1.43 1.11-1.84 0.00528 TRUE FALSE FALSE TRUE Both 529 5289 GRCh37/hg19 P<=5e-08 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000605/ScoringFiles/ phewas/PRSWEB_PHECODE189.11_GWAS-Catalog-r2019-05-03-X189.11_P_5e-08_UKB_20200608/all.tsv phewas/PRSWEB_PHECODE189.11_GWAS-Catalog-r2019-05-03-X189.11_P_5e-08_UKB_20200608/exclusion.tsv 2020-06-08 prsweb-phecode189-11-gwas-catalog-r2019-05-03-x189-11-pt-ukb-20200608 prsweb-phecode189-11-gwas-catalog-r2019-05-03-x189-11-pt-ukb-20200608 PRSWEB_PHECODE189.11_GWAS-Catalog-r2019-05-03-X189.11_PT_UKB_20200608 P&T PRSWEB_PHECODE189.11_GWAS-Catalog-r2019-05-03-X189.11_PT_UKB_20200608 189.11 Renal cell carcinoma;Wilms tumor Binary 15 unique SNPs UKB UK Biobank P&T GWAS Catalog (2019-05-03) 22544364;28598434 https://www.ncbi.nlm.nih.gov/pubmed/?term=22544364+28598434 12 0.00077 0.000683427 0.0825 0.517 0.492-0.54 OR 2.17 1.13-4.14 2.17 1.13-4.14 1.86 1.13-3.04 1.86 1.13-3.04 1.28 0.88-1.85 1.28 0.88-1.85 1.29 0.979-1.69 1.29 0.979-1.69 1.31 1.08-1.6 1.31 1.08-1.6 1.13 0.871-1.47 0.356 1.06 0.811-1.38 0.685 1.43 1.11-1.84 0.00528 TRUE FALSE FALSE TRUE Both 529 5289 GRCh37/hg19 P<=5e-08 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000606/ScoringFiles/ phewas/PRSWEB_PHECODE189.11_GWAS-Catalog-r2019-05-03-X189.11_PT_UKB_20200608/all.tsv phewas/PRSWEB_PHECODE189.11_GWAS-Catalog-r2019-05-03-X189.11_PT_UKB_20200608/exclusion.tsv 2020-06-08 prsweb-phecode189-2-20001-1035-p-5e-05-mgi-20200608 prsweb-phecode189-2-20001-1035-p-5e-05-mgi-20200608 PRSWEB_PHECODE189.2_20001-1035_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE189.2_20001-1035_P_5e-05_MGI_20200608 189.2 Cancer code, self-reported: bladder cancer Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 131 0.28 0.00197139 0.0923 0.51 0.491-0.529 OR 0.799 0.354-1.8 0.799 0.354-1.8 0.886 0.512-1.53 0.886 0.512-1.53 1.02 0.729-1.43 1.02 0.729-1.43 1.11 0.872-1.4 1.11 0.872-1.4 1.06 0.9-1.26 1.06 0.9-1.26 1.22 0.989-1.51 0.0632 1.1 0.885-1.36 0.396 1.17 0.95-1.45 0.137 FALSE FALSE FALSE FALSE Both 789 6833 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode189-2-c3-bladder-p-5e-05-mgi-20200608 prsweb-phecode189-2-c3-bladder-p-5e-05-mgi-20200608 PRSWEB_PHECODE189.2_C3-BLADDER_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE189.2_C3-BLADDER_P_5e-05_MGI_20200608 189.2 Malignant neoplasm of bladder Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 125 0.51 8.38031e-06 0.0923 0.502 0.481-0.523 OR 1.01 0.489-2.07 1.01 0.489-2.07 1 0.598-1.69 1 0.598-1.69 1.01 0.723-1.41 1.01 0.723-1.41 0.938 0.729-1.21 0.938 0.729-1.21 1.03 0.873-1.22 1.03 0.873-1.22 0.993 0.805-1.22 0.945 1.02 0.829-1.26 0.845 1.04 0.846-1.28 0.703 FALSE FALSE FALSE FALSE Both 789 6833 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode189-2-c67-p-5e-05-mgi-20200608 prsweb-phecode189-2-c67-p-5e-05-mgi-20200608 PRSWEB_PHECODE189.2_C67_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE189.2_C67_P_5e-05_MGI_20200608 189.2 Diagnoses - main ICD10: C67 Malignant neoplasm of bladder Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 147 0.24 3.00924e-05 0.0922 0.504 0.483-0.525 OR 1.03 0.499-2.11 1.03 0.499-2.11 1.01 0.6-1.69 1.01 0.6-1.69 1.17 0.85-1.6 1.17 0.85-1.6 1.21 0.961-1.52 1.21 0.961-1.52 0.996 0.84-1.18 0.996 0.84-1.18 0.92 0.743-1.14 0.443 1.1 0.899-1.35 0.349 1 0.814-1.24 0.982 FALSE FALSE FALSE FALSE Both 789 6833 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode189-2-gwas-catalog-r2019-05-03-x189-2-p-5e-05-mgi-20200608 prsweb-phecode189-2-gwas-catalog-r2019-05-03-x189-2-p-5e-05-mgi-20200608 PRSWEB_PHECODE189.2_GWAS-Catalog-r2019-05-03-X189.2_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE189.2_GWAS-Catalog-r2019-05-03-X189.2_P_5e-05_MGI_20200608 189.2 Bladder cancer;Urinary bladder cancer Binary 18 unique SNPs MGI Michigan Genomics Initiative Fixed threshold (5e-05) GWAS Catalog (2019-05-03) 18794855;19648920;20348956;20972438;21750109;24163127;24861552 https://www.ncbi.nlm.nih.gov/pubmed/?term=18794855+19648920+20348956+20972438+21750109+24163127+24861552 15 1.9e-11 0.00344644 0.0917 0.572 0.55-0.594 OR 2.12 1.22-3.66 2.12 1.22-3.66 1.8 1.19-2.72 1.8 1.19-2.72 1.68 1.27-2.21 1.68 1.27-2.21 1.63 1.32-2.01 1.63 1.32-2.01 1.63 1.39-1.9 1.63 1.39-1.9 1.24 0.983-1.57 0.0694 1.43 1.14-1.79 0.00201 1.99 1.61-2.47 2.85e-10 TRUE FALSE FALSE FALSE Both 789 6833 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode189-2-ukbb-saige-hrc-x189-2-p-5e-05-mgi-20200608 prsweb-phecode189-2-ukbb-saige-hrc-x189-2-p-5e-05-mgi-20200608 PRSWEB_PHECODE189.2_UKBB-SAIGE-HRC-X189.2_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE189.2_UKBB-SAIGE-HRC-X189.2_P_5e-05_MGI_20200608 189.2 Cancer of bladder Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 130 0.019 0.00192876 0.0922 0.519 0.499-0.541 OR 1.59 0.876-2.87 1.59 0.876-2.87 1.49 0.96-2.31 1.49 0.96-2.31 1.2 0.878-1.64 1.2 0.878-1.64 1.2 0.955-1.51 1.2 0.955-1.51 1.16 0.981-1.37 1.16 0.981-1.37 1.09 0.88-1.34 0.444 0.978 0.789-1.21 0.843 1.17 0.95-1.44 0.139 TRUE FALSE FALSE FALSE Both 789 6833 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode189-2-20001-1035-p-5e-06-mgi-20200608 prsweb-phecode189-2-20001-1035-p-5e-06-mgi-20200608 PRSWEB_PHECODE189.2_20001-1035_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE189.2_20001-1035_P_5e-06_MGI_20200608 189.2 Cancer code, self-reported: bladder cancer Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 17 0.024 2.94001e-06 0.0922 0.505 0.484-0.525 OR 1.41 0.75-2.66 1.41 0.75-2.66 1.32 0.822-2.12 1.32 0.822-2.12 0.935 0.661-1.32 0.935 0.661-1.32 1.16 0.916-1.46 1.16 0.916-1.46 1.14 0.969-1.35 1.14 0.969-1.35 1.24 0.997-1.54 0.0527 1.31 1.05-1.62 0.0154 1.35 1.09-1.68 0.0054 TRUE FALSE FALSE FALSE Both 789 6833 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode189-2-c67-p-5e-06-mgi-20200608 prsweb-phecode189-2-c67-p-5e-06-mgi-20200608 PRSWEB_PHECODE189.2_C67_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE189.2_C67_P_5e-06_MGI_20200608 189.2 Diagnoses - main ICD10: C67 Malignant neoplasm of bladder Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 28 0.68 0.000431496 0.0923 0.497 0.476-0.517 OR 0.43 0.146-1.27 0.43 0.146-1.27 0.595 0.306-1.16 0.595 0.306-1.16 0.911 0.642-1.29 0.911 0.642-1.29 0.968 0.754-1.24 0.968 0.754-1.24 1.01 0.85-1.19 1.01 0.85-1.19 1.08 0.875-1.34 0.469 1.14 0.926-1.41 0.216 1.07 0.866-1.32 0.527 FALSE FALSE FALSE FALSE Both 789 6833 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode189-2-gwas-catalog-r2019-05-03-x189-2-p-5e-06-mgi-20200608 prsweb-phecode189-2-gwas-catalog-r2019-05-03-x189-2-p-5e-06-mgi-20200608 PRSWEB_PHECODE189.2_GWAS-Catalog-r2019-05-03-X189.2_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE189.2_GWAS-Catalog-r2019-05-03-X189.2_P_5e-06_MGI_20200608 189.2 Bladder cancer;Urinary bladder cancer Binary 18 unique SNPs MGI Michigan Genomics Initiative Fixed threshold (5e-06) GWAS Catalog (2019-05-03) 18794855;19648920;20348956;20972438;21750109;24163127;24861552 https://www.ncbi.nlm.nih.gov/pubmed/?term=18794855+19648920+20348956+20972438+21750109+24163127+24861552 15 1.9e-11 0.00344644 0.0917 0.572 0.55-0.594 OR 2.12 1.22-3.66 2.12 1.22-3.66 1.8 1.19-2.72 1.8 1.19-2.72 1.68 1.27-2.21 1.68 1.27-2.21 1.63 1.32-2.01 1.63 1.32-2.01 1.63 1.39-1.9 1.63 1.39-1.9 1.24 0.983-1.57 0.0694 1.43 1.14-1.79 0.00201 1.99 1.61-2.47 2.85e-10 TRUE FALSE FALSE FALSE Both 789 6833 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode189-2-ukbb-saige-hrc-x189-2-p-5e-06-mgi-20200608 prsweb-phecode189-2-ukbb-saige-hrc-x189-2-p-5e-06-mgi-20200608 PRSWEB_PHECODE189.2_UKBB-SAIGE-HRC-X189.2_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE189.2_UKBB-SAIGE-HRC-X189.2_P_5e-06_MGI_20200608 189.2 Cancer of bladder Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 21 0.00011 0.000818731 0.0921 0.537 0.515-0.558 OR 1.08 0.526-2.23 1.08 0.526-2.23 1.16 0.708-1.9 1.16 0.708-1.9 1.41 1.05-1.9 1.41 1.05-1.9 1.36 1.09-1.7 1.36 1.09-1.7 1.29 1.1-1.52 1.29 1.1-1.52 1.27 1.02-1.59 0.0345 1.28 1.03-1.6 0.0264 1.56 1.26-1.93 4.6e-05 TRUE FALSE FALSE FALSE Both 789 6833 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode189-2-c67-p-5e-07-mgi-20200608 prsweb-phecode189-2-c67-p-5e-07-mgi-20200608 PRSWEB_PHECODE189.2_C67_P_5e-07_MGI_20200608 P_5e-07 PRSWEB_PHECODE189.2_C67_P_5e-07_MGI_20200608 189.2 Diagnoses - main ICD10: C67 Malignant neoplasm of bladder Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-07) UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 7 0.02 3.66687e-05 0.0922 0.512 0.492-0.53 OR 0.578 0.221-1.51 0.578 0.221-1.51 0.929 0.536-1.61 0.929 0.536-1.61 0.987 0.701-1.39 0.987 0.701-1.39 1.17 0.931-1.48 1.17 0.931-1.48 1.14 0.969-1.35 1.14 0.969-1.35 1.1 0.886-1.38 0.378 1.32 1.07-1.63 0.00984 1.3 1.05-1.61 0.0155 TRUE FALSE FALSE FALSE Both 789 6833 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode189-2-gwas-catalog-r2019-05-03-x189-2-p-5e-07-mgi-20200608 prsweb-phecode189-2-gwas-catalog-r2019-05-03-x189-2-p-5e-07-mgi-20200608 PRSWEB_PHECODE189.2_GWAS-Catalog-r2019-05-03-X189.2_P_5e-07_MGI_20200608 P_5e-07 PRSWEB_PHECODE189.2_GWAS-Catalog-r2019-05-03-X189.2_P_5e-07_MGI_20200608 189.2 Bladder cancer;Urinary bladder cancer Binary 18 unique SNPs MGI Michigan Genomics Initiative Fixed threshold (5e-07) GWAS Catalog (2019-05-03) 18794855;19648920;20348956;20972438;21750109;24163127;24861552 https://www.ncbi.nlm.nih.gov/pubmed/?term=18794855+19648920+20348956+20972438+21750109+24163127+24861552 14 1.6e-11 0.00314591 0.0917 0.571 0.55-0.594 OR 1.32 0.684-2.56 1.32 0.684-2.56 2.1 1.43-3.1 2.1 1.43-3.1 1.69 1.28-2.22 1.69 1.28-2.22 1.72 1.4-2.11 1.72 1.4-2.11 1.63 1.39-1.9 1.63 1.39-1.9 1.28 1.02-1.62 0.0338 1.39 1.1-1.74 0.005 1.99 1.6-2.46 3.22e-10 TRUE FALSE FALSE FALSE Both 789 6833 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode189-2-ukbb-saige-hrc-x189-2-p-5e-07-mgi-20200608 prsweb-phecode189-2-ukbb-saige-hrc-x189-2-p-5e-07-mgi-20200608 PRSWEB_PHECODE189.2_UKBB-SAIGE-HRC-X189.2_P_5e-07_MGI_20200608 P_5e-07 PRSWEB_PHECODE189.2_UKBB-SAIGE-HRC-X189.2_P_5e-07_MGI_20200608 189.2 Cancer of bladder Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative Fixed threshold (5e-07) UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 8 5.1e-07 0.00107835 0.0919 0.548 0.526-0.569 OR 1.68 0.929-3.04 1.68 0.929-3.04 1.26 0.787-2.02 1.26 0.787-2.02 1.41 1.05-1.89 1.41 1.05-1.89 1.34 1.07-1.67 1.34 1.07-1.67 1.38 1.17-1.62 1.38 1.17-1.62 1.32 1.05-1.65 0.017 1.38 1.11-1.73 0.00441 1.69 1.37-2.1 1.49e-06 TRUE FALSE FALSE FALSE Both 789 6833 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode189-2-gwas-catalog-r2019-05-03-x189-2-p-5e-09-mgi-20200608 prsweb-phecode189-2-gwas-catalog-r2019-05-03-x189-2-p-5e-09-mgi-20200608 PRSWEB_PHECODE189.2_GWAS-Catalog-r2019-05-03-X189.2_P_5e-09_MGI_20200608 P_5e-09 PRSWEB_PHECODE189.2_GWAS-Catalog-r2019-05-03-X189.2_P_5e-09_MGI_20200608 189.2 Bladder cancer;Urinary bladder cancer Binary 18 unique SNPs MGI Michigan Genomics Initiative Fixed threshold (5e-09) GWAS Catalog (2019-05-03) 18794855;19648920;20348956;20972438;21750109;24163127;24861552 https://www.ncbi.nlm.nih.gov/pubmed/?term=18794855+19648920+20348956+20972438+21750109+24163127+24861552 12 2.5e-12 0.00330397 0.0916 0.574 0.552-0.596 OR 1.95 1.11-3.42 1.95 1.11-3.42 2.18 1.49-3.2 2.18 1.49-3.2 1.78 1.36-2.34 1.78 1.36-2.34 1.58 1.28-1.95 1.58 1.28-1.95 1.53 1.31-1.79 1.53 1.31-1.79 1.24 0.982-1.57 0.0711 1.55 1.24-1.94 0.000139 1.93 1.56-2.4 2.31e-09 TRUE FALSE FALSE FALSE Both 789 6833 GRCh37/hg19 P<=5e-09 2020-06-08 prsweb-phecode189-2-gwas-catalog-r2019-05-03-x189-2-p-5e-08-mgi-20200608 prsweb-phecode189-2-gwas-catalog-r2019-05-03-x189-2-p-5e-08-mgi-20200608 PRSWEB_PHECODE189.2_GWAS-Catalog-r2019-05-03-X189.2_P_5e-08_MGI_20200608 P_5e-08 PRSWEB_PHECODE189.2_GWAS-Catalog-r2019-05-03-X189.2_P_5e-08_MGI_20200608 189.2 Bladder cancer;Urinary bladder cancer Binary 18 unique SNPs MGI Michigan Genomics Initiative GWAS Hits GWAS Catalog (2019-05-03) 18794855;19648920;20348956;20972438;21750109;24163127;24861552 https://www.ncbi.nlm.nih.gov/pubmed/?term=18794855+19648920+20348956+20972438+21750109+24163127+24861552 13 8.1e-12 0.00358481 0.0917 0.572 0.55-0.594 OR 1.47 0.779-2.77 1.47 0.779-2.77 1.99 1.34-2.96 1.99 1.34-2.96 1.75 1.33-2.3 1.75 1.33-2.3 1.52 1.23-1.88 1.52 1.23-1.88 1.66 1.42-1.94 1.66 1.42-1.94 1.13 0.898-1.43 0.292 1.36 1.08-1.7 0.00764 1.94 1.57-2.39 8.27e-10 TRUE FALSE FALSE TRUE Both 789 6833 GRCh37/hg19 P<=5e-08 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000610/ScoringFiles/ phewas/PRSWEB_PHECODE189.2_GWAS-Catalog-r2019-05-03-X189.2_P_5e-08_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE189.2_GWAS-Catalog-r2019-05-03-X189.2_P_5e-08_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode189-2-20001-1035-pt-mgi-20200608 prsweb-phecode189-2-20001-1035-pt-mgi-20200608 PRSWEB_PHECODE189.2_20001-1035_PT_MGI_20200608 P&T PRSWEB_PHECODE189.2_20001-1035_PT_MGI_20200608 189.2 Cancer code, self-reported: bladder cancer Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative P&T UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 155 0.44 0.00212147 0.0923 0.507 0.488-0.527 OR 0.549 0.21-1.44 0.549 0.21-1.44 0.896 0.518-1.55 0.896 0.518-1.55 0.823 0.572-1.18 0.823 0.572-1.18 0.946 0.736-1.21 0.946 0.736-1.21 1.04 0.878-1.23 1.04 0.878-1.23 1.33 1.07-1.64 0.00884 1.15 0.924-1.42 0.215 1.19 0.963-1.48 0.106 FALSE FALSE FALSE FALSE Both 789 6833 GRCh37/hg19 P<=6.31e-05 2020-06-08 prsweb-phecode189-2-c3-bladder-pt-mgi-20200608 prsweb-phecode189-2-c3-bladder-pt-mgi-20200608 PRSWEB_PHECODE189.2_C3-BLADDER_PT_MGI_20200608 P&T PRSWEB_PHECODE189.2_C3-BLADDER_PT_MGI_20200608 189.2 Malignant neoplasm of bladder Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative P&T UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 5 0.51 0.00065475 0.0923 0.468 0.449-0.487 OR 0.767 0.34-1.73 0.767 0.34-1.73 0.82 0.465-1.44 0.82 0.465-1.44 0.863 0.603-1.24 0.863 0.603-1.24 1.02 0.802-1.3 1.02 0.802-1.3 1.12 0.951-1.33 1.12 0.951-1.33 0.929 0.742-1.16 0.524 1 0.803-1.25 0.984 1.11 0.895-1.38 0.337 FALSE FALSE FALSE FALSE Both 789 6833 GRCh37/hg19 P<=7.94e-07 2020-06-08 prsweb-phecode189-2-c67-pt-mgi-20200608 prsweb-phecode189-2-c67-pt-mgi-20200608 PRSWEB_PHECODE189.2_C67_PT_MGI_20200608 P&T PRSWEB_PHECODE189.2_C67_PT_MGI_20200608 189.2 Diagnoses - main ICD10: C67 Malignant neoplasm of bladder Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative P&T UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 10 0.12 0.000600238 0.0922 0.504 0.483-0.524 OR 1.1 0.534-2.26 1.1 0.534-2.26 0.672 0.357-1.27 0.672 0.357-1.27 0.945 0.668-1.34 0.945 0.668-1.34 1.1 0.868-1.4 1.1 0.868-1.4 1.07 0.903-1.26 1.07 0.903-1.26 0.946 0.763-1.17 0.618 1.16 0.942-1.43 0.162 1.11 0.897-1.36 0.346 FALSE FALSE FALSE FALSE Both 789 6833 GRCh37/hg19 P<=1.58e-06 2020-06-08 prsweb-phecode189-2-gwas-catalog-r2019-05-03-x189-2-pt-mgi-20200608 prsweb-phecode189-2-gwas-catalog-r2019-05-03-x189-2-pt-mgi-20200608 PRSWEB_PHECODE189.2_GWAS-Catalog-r2019-05-03-X189.2_PT_MGI_20200608 P&T PRSWEB_PHECODE189.2_GWAS-Catalog-r2019-05-03-X189.2_PT_MGI_20200608 189.2 Bladder cancer;Urinary bladder cancer Binary 18 unique SNPs MGI Michigan Genomics Initiative P&T GWAS Catalog (2019-05-03) 18794855;19648920;20348956;20972438;21750109;24163127;24861552 https://www.ncbi.nlm.nih.gov/pubmed/?term=18794855+19648920+20348956+20972438+21750109+24163127+24861552 13 8.1e-12 0.00358481 0.0917 0.572 0.55-0.594 OR 1.47 0.779-2.77 1.47 0.779-2.77 1.99 1.34-2.96 1.99 1.34-2.96 1.75 1.33-2.3 1.75 1.33-2.3 1.52 1.23-1.88 1.52 1.23-1.88 1.66 1.42-1.94 1.66 1.42-1.94 1.13 0.898-1.43 0.292 1.36 1.08-1.7 0.00764 1.94 1.57-2.39 8.27e-10 TRUE FALSE FALSE TRUE Both 789 6833 GRCh37/hg19 P<=5e-08 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000612/ScoringFiles/ phewas/PRSWEB_PHECODE189.2_GWAS-Catalog-r2019-05-03-X189.2_PT_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE189.2_GWAS-Catalog-r2019-05-03-X189.2_PT_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode189-2-ukbb-saige-hrc-x189-2-pt-mgi-20200608 prsweb-phecode189-2-ukbb-saige-hrc-x189-2-pt-mgi-20200608 PRSWEB_PHECODE189.2_UKBB-SAIGE-HRC-X189.2_PT_MGI_20200608 P&T PRSWEB_PHECODE189.2_UKBB-SAIGE-HRC-X189.2_PT_MGI_20200608 189.2 Cancer of bladder Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative P&T UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 106 0.032 0.00245224 0.0922 0.519 0.498-0.541 OR 0.788 0.35-1.78 0.788 0.35-1.78 1.18 0.73-1.92 1.18 0.73-1.92 1.27 0.935-1.73 1.27 0.935-1.73 1.12 0.889-1.42 1.12 0.889-1.42 1.13 0.957-1.33 1.13 0.957-1.33 1.13 0.913-1.4 0.263 1.14 0.921-1.41 0.227 1.22 0.99-1.51 0.0625 TRUE FALSE FALSE TRUE Both 789 6833 GRCh37/hg19 P<=3.98e-05 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000615/ScoringFiles/ phewas/PRSWEB_PHECODE189.2_UKBB-SAIGE-HRC-X189.2_PT_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE189.2_UKBB-SAIGE-HRC-X189.2_PT_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode189-2-20001-1035-prs-cs-mgi-20200608 prsweb-phecode189-2-20001-1035-prs-cs-mgi-20200608 PRSWEB_PHECODE189.2_20001-1035_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE189.2_20001-1035_PRS-CS_MGI_20200608 189.2 Cancer code, self-reported: bladder cancer Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative PRS-CS UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1095241 0.015 0.000762339 0.0922 0.531 0.509-0.551 OR 0.671 0.279-1.61 0.671 0.279-1.61 0.889 0.513-1.54 0.889 0.513-1.54 1.12 0.81-1.55 1.12 0.81-1.55 1.22 0.966-1.53 1.22 0.966-1.53 1.16 0.985-1.37 1.16 0.985-1.37 0.995 0.799-1.24 0.966 1.25 1.02-1.54 0.035 1.26 1.02-1.55 0.0317 TRUE FALSE FALSE TRUE Both 789 6833 GRCh37/hg19 auto https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000607/ScoringFiles/ phewas/PRSWEB_PHECODE189.2_20001-1035_PRS-CS_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE189.2_20001-1035_PRS-CS_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode189-2-c3-bladder-prs-cs-mgi-20200608 prsweb-phecode189-2-c3-bladder-prs-cs-mgi-20200608 PRSWEB_PHECODE189.2_C3-BLADDER_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE189.2_C3-BLADDER_PRS-CS_MGI_20200608 189.2 Malignant neoplasm of bladder Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative PRS-CS UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1097063 0.033 8.08514e-05 0.0922 0.521 0.499-0.541 OR 1.53 0.832-2.83 1.53 0.832-2.83 1.37 0.86-2.17 1.37 0.86-2.17 1.33 0.986-1.8 1.33 0.986-1.8 1.26 1-1.58 1.26 1-1.58 1.13 0.957-1.33 1.13 0.957-1.33 1.14 0.918-1.41 0.241 1.11 0.892-1.37 0.359 1.22 0.988-1.5 0.0641 TRUE FALSE FALSE TRUE Both 789 6833 GRCh37/hg19 auto https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000608/ScoringFiles/ phewas/PRSWEB_PHECODE189.2_C3-BLADDER_PRS-CS_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE189.2_C3-BLADDER_PRS-CS_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode189-2-c67-prs-cs-mgi-20200608 prsweb-phecode189-2-c67-prs-cs-mgi-20200608 PRSWEB_PHECODE189.2_C67_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE189.2_C67_PRS-CS_MGI_20200608 189.2 Diagnoses - main ICD10: C67 Malignant neoplasm of bladder Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative PRS-CS UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1109663 0.081 0.00181871 0.0922 0.517 0.495-0.539 OR 1.52 0.806-2.87 1.52 0.806-2.87 1.35 0.841-2.16 1.35 0.841-2.16 1.06 0.758-1.47 1.06 0.758-1.47 1.3 1.04-1.62 1.3 1.04-1.62 1.1 0.929-1.3 1.1 0.929-1.3 1.05 0.854-1.3 0.624 1.02 0.828-1.27 0.827 1.13 0.916-1.39 0.258 FALSE FALSE FALSE FALSE Both 789 6833 GRCh37/hg19 auto 2020-06-08 prsweb-phecode189-2-ukbb-saige-hrc-x189-2-prs-cs-mgi-20200608 prsweb-phecode189-2-ukbb-saige-hrc-x189-2-prs-cs-mgi-20200608 PRSWEB_PHECODE189.2_UKBB-SAIGE-HRC-X189.2_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE189.2_UKBB-SAIGE-HRC-X189.2_PRS-CS_MGI_20200608 189.2 Cancer of bladder Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative PRS-CS UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1119238 0.027 0.00161079 0.0922 0.525 0.503-0.547 OR 0.675 0.28-1.62 0.675 0.28-1.62 0.862 0.489-1.52 0.862 0.489-1.52 1.03 0.736-1.44 1.03 0.736-1.44 1.31 1.04-1.64 1.31 1.04-1.64 1.15 0.978-1.36 1.15 0.978-1.36 1.12 0.9-1.39 0.312 1.18 0.955-1.46 0.124 1.27 1.03-1.56 0.0278 TRUE FALSE FALSE TRUE Both 789 6833 GRCh37/hg19 auto https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000614/ScoringFiles/ phewas/PRSWEB_PHECODE189.2_UKBB-SAIGE-HRC-X189.2_PRS-CS_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE189.2_UKBB-SAIGE-HRC-X189.2_PRS-CS_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode189-2-20001-1035-lassosum-mgi-20200608 prsweb-phecode189-2-20001-1035-lassosum-mgi-20200608 PRSWEB_PHECODE189.2_20001-1035_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE189.2_20001-1035_LASSOSUM_MGI_20200608 189.2 Cancer code, self-reported: bladder cancer Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative lassosum UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 29094 0.12 0.00201186 0.0922 0.516 0.497-0.536 OR 0.943 0.439-2.02 0.943 0.439-2.02 1.12 0.673-1.85 1.12 0.673-1.85 1.26 0.926-1.72 1.26 0.926-1.72 1.01 0.792-1.29 1.01 0.792-1.29 0.974 0.821-1.16 0.974 0.821-1.16 1.19 0.962-1.47 0.109 1.24 1.01-1.53 0.0442 1.11 0.892-1.37 0.355 FALSE FALSE FALSE FALSE Both 789 6833 GRCh37/hg19 s=1;Lambda=0.04833 2020-06-08 prsweb-phecode189-2-c67-lassosum-mgi-20200608 prsweb-phecode189-2-c67-lassosum-mgi-20200608 PRSWEB_PHECODE189.2_C67_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE189.2_C67_LASSOSUM_MGI_20200608 189.2 Diagnoses - main ICD10: C67 Malignant neoplasm of bladder Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative lassosum UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1130 0.0074 0.00275366 0.0922 0.528 0.508-0.549 OR 1.69 0.934-3.06 1.69 0.934-3.06 1.22 0.754-1.98 1.22 0.754-1.98 1.23 0.906-1.68 1.23 0.906-1.68 1.18 0.937-1.49 1.18 0.937-1.49 1.08 0.916-1.28 1.08 0.916-1.28 1.23 0.986-1.52 0.0662 1.33 1.07-1.65 0.0091 1.28 1.03-1.58 0.026 TRUE FALSE FALSE TRUE Both 789 6833 GRCh37/hg19 s=1;Lambda=0.04833 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000609/ScoringFiles/ phewas/PRSWEB_PHECODE189.2_C67_LASSOSUM_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE189.2_C67_LASSOSUM_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode189-2-ukbb-saige-hrc-x189-2-lassosum-mgi-20200608 prsweb-phecode189-2-ukbb-saige-hrc-x189-2-lassosum-mgi-20200608 PRSWEB_PHECODE189.2_UKBB-SAIGE-HRC-X189.2_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE189.2_UKBB-SAIGE-HRC-X189.2_LASSOSUM_MGI_20200608 189.2 Cancer of bladder Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative lassosum UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 24359 0.00059 0.00365252 0.0921 0.538 0.517-0.557 OR 0.983 0.459-2.11 0.983 0.459-2.11 1.05 0.623-1.76 1.05 0.623-1.76 1.11 0.807-1.54 1.11 0.807-1.54 1.04 0.819-1.33 1.04 0.819-1.33 1.16 0.986-1.37 1.16 0.986-1.37 1.31 1.05-1.64 0.0176 1.46 1.17-1.81 0.000666 1.47 1.18-1.82 0.00057 TRUE FALSE FALSE TRUE Both 789 6833 GRCh37/hg19 s=1;Lambda=0.02976 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000616/ScoringFiles/ phewas/PRSWEB_PHECODE189.2_UKBB-SAIGE-HRC-X189.2_LASSOSUM_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE189.2_UKBB-SAIGE-HRC-X189.2_LASSOSUM_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode189-2-gwas-catalog-r2019-05-03-x189-2-p-5e-05-ukb-20200608 prsweb-phecode189-2-gwas-catalog-r2019-05-03-x189-2-p-5e-05-ukb-20200608 PRSWEB_PHECODE189.2_GWAS-Catalog-r2019-05-03-X189.2_P_5e-05_UKB_20200608 P_5e-05 PRSWEB_PHECODE189.2_GWAS-Catalog-r2019-05-03-X189.2_P_5e-05_UKB_20200608 189.2 Bladder cancer;Urinary bladder cancer Binary 18 unique SNPs UKB UK Biobank Fixed threshold (5e-05) GWAS Catalog (2019-05-03) 18794855;19648920;20348956;20972438;21750109;24163127;24861552 https://www.ncbi.nlm.nih.gov/pubmed/?term=18794855+19648920+20348956+20972438+21750109+24163127+24861552 15 1.4e-18 0.0151919 0.0821 0.571 0.555-0.588 OR 2.91 1.99-4.24 2.91 1.99-4.24 2.7 2.04-3.57 2.7 2.04-3.57 2.12 1.73-2.59 2.12 1.73-2.59 1.6 1.35-1.89 1.6 1.35-1.89 1.51 1.33-1.71 1.51 1.33-1.71 1.09 0.904-1.31 0.374 1.46 1.23-1.74 1.78e-05 1.79 1.51-2.12 1.43e-11 TRUE FALSE FALSE FALSE Both 1229 12301 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode189-2-gwas-catalog-r2019-05-03-x189-2-p-5e-06-ukb-20200608 prsweb-phecode189-2-gwas-catalog-r2019-05-03-x189-2-p-5e-06-ukb-20200608 PRSWEB_PHECODE189.2_GWAS-Catalog-r2019-05-03-X189.2_P_5e-06_UKB_20200608 P_5e-06 PRSWEB_PHECODE189.2_GWAS-Catalog-r2019-05-03-X189.2_P_5e-06_UKB_20200608 189.2 Bladder cancer;Urinary bladder cancer Binary 18 unique SNPs UKB UK Biobank Fixed threshold (5e-06) GWAS Catalog (2019-05-03) 18794855;19648920;20348956;20972438;21750109;24163127;24861552 https://www.ncbi.nlm.nih.gov/pubmed/?term=18794855+19648920+20348956+20972438+21750109+24163127+24861552 15 1.4e-18 0.0151919 0.0821 0.571 0.555-0.588 OR 2.91 1.99-4.24 2.91 1.99-4.24 2.7 2.04-3.57 2.7 2.04-3.57 2.12 1.73-2.59 2.12 1.73-2.59 1.6 1.35-1.89 1.6 1.35-1.89 1.51 1.33-1.71 1.51 1.33-1.71 1.09 0.904-1.31 0.374 1.46 1.23-1.74 1.78e-05 1.79 1.51-2.12 1.43e-11 TRUE FALSE FALSE FALSE Both 1229 12301 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode189-2-gwas-catalog-r2019-05-03-x189-2-p-5e-07-ukb-20200608 prsweb-phecode189-2-gwas-catalog-r2019-05-03-x189-2-p-5e-07-ukb-20200608 PRSWEB_PHECODE189.2_GWAS-Catalog-r2019-05-03-X189.2_P_5e-07_UKB_20200608 P_5e-07 PRSWEB_PHECODE189.2_GWAS-Catalog-r2019-05-03-X189.2_P_5e-07_UKB_20200608 189.2 Bladder cancer;Urinary bladder cancer Binary 18 unique SNPs UKB UK Biobank Fixed threshold (5e-07) GWAS Catalog (2019-05-03) 18794855;19648920;20348956;20972438;21750109;24163127;24861552 https://www.ncbi.nlm.nih.gov/pubmed/?term=18794855+19648920+20348956+20972438+21750109+24163127+24861552 14 1.1e-17 0.0146094 0.0821 0.569 0.553-0.586 OR 3.07 2.12-4.46 3.07 2.12-4.46 2.61 1.96-3.46 2.61 1.96-3.46 2.04 1.66-2.51 2.04 1.66-2.51 1.67 1.42-1.97 1.67 1.42-1.97 1.51 1.33-1.71 1.51 1.33-1.71 1.15 0.959-1.39 0.129 1.43 1.2-1.71 6.21e-05 1.8 1.52-2.14 8.27e-12 TRUE FALSE FALSE FALSE Both 1229 12301 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode189-2-gwas-catalog-r2019-05-03-x189-2-p-5e-09-ukb-20200608 prsweb-phecode189-2-gwas-catalog-r2019-05-03-x189-2-p-5e-09-ukb-20200608 PRSWEB_PHECODE189.2_GWAS-Catalog-r2019-05-03-X189.2_P_5e-09_UKB_20200608 P_5e-09 PRSWEB_PHECODE189.2_GWAS-Catalog-r2019-05-03-X189.2_P_5e-09_UKB_20200608 189.2 Bladder cancer;Urinary bladder cancer Binary 18 unique SNPs UKB UK Biobank Fixed threshold (5e-09) GWAS Catalog (2019-05-03) 18794855;19648920;20348956;20972438;21750109;24163127;24861552 https://www.ncbi.nlm.nih.gov/pubmed/?term=18794855+19648920+20348956+20972438+21750109+24163127+24861552 12 1.7e-17 0.0132367 0.0821 0.569 0.552-0.586 OR 2.74 1.86-4.03 2.74 1.86-4.03 2.37 1.77-3.18 2.37 1.77-3.18 1.99 1.61-2.44 1.99 1.61-2.44 1.78 1.52-2.1 1.78 1.52-2.1 1.53 1.35-1.73 1.53 1.35-1.73 1.17 0.973-1.4 0.0952 1.41 1.18-1.68 0.000152 1.82 1.54-2.16 3.64e-12 TRUE FALSE FALSE FALSE Both 1229 12301 GRCh37/hg19 P<=5e-09 2020-06-08 prsweb-phecode189-2-gwas-catalog-r2019-05-03-x189-2-p-5e-08-ukb-20200608 prsweb-phecode189-2-gwas-catalog-r2019-05-03-x189-2-p-5e-08-ukb-20200608 PRSWEB_PHECODE189.2_GWAS-Catalog-r2019-05-03-X189.2_P_5e-08_UKB_20200608 P_5e-08 PRSWEB_PHECODE189.2_GWAS-Catalog-r2019-05-03-X189.2_P_5e-08_UKB_20200608 189.2 Bladder cancer;Urinary bladder cancer Binary 18 unique SNPs UKB UK Biobank GWAS Hits GWAS Catalog (2019-05-03) 18794855;19648920;20348956;20972438;21750109;24163127;24861552 https://www.ncbi.nlm.nih.gov/pubmed/?term=18794855+19648920+20348956+20972438+21750109+24163127+24861552 13 5.1e-17 0.0145512 0.0821 0.567 0.551-0.584 OR 2.66 1.79-3.93 2.66 1.79-3.93 2.35 1.75-3.15 2.35 1.75-3.15 2.02 1.64-2.48 2.02 1.64-2.48 1.65 1.4-1.94 1.65 1.4-1.94 1.51 1.33-1.71 1.51 1.33-1.71 1.2 0.998-1.44 0.0523 1.41 1.18-1.69 0.000127 1.81 1.53-2.14 6.56e-12 TRUE FALSE FALSE TRUE Both 1229 12301 GRCh37/hg19 P<=5e-08 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000611/ScoringFiles/ phewas/PRSWEB_PHECODE189.2_GWAS-Catalog-r2019-05-03-X189.2_P_5e-08_UKB_20200608/all.tsv phewas/PRSWEB_PHECODE189.2_GWAS-Catalog-r2019-05-03-X189.2_P_5e-08_UKB_20200608/exclusion.tsv 2020-06-08 prsweb-phecode189-2-gwas-catalog-r2019-05-03-x189-2-pt-ukb-20200608 prsweb-phecode189-2-gwas-catalog-r2019-05-03-x189-2-pt-ukb-20200608 PRSWEB_PHECODE189.2_GWAS-Catalog-r2019-05-03-X189.2_PT_UKB_20200608 P&T PRSWEB_PHECODE189.2_GWAS-Catalog-r2019-05-03-X189.2_PT_UKB_20200608 189.2 Bladder cancer;Urinary bladder cancer Binary 18 unique SNPs UKB UK Biobank P&T GWAS Catalog (2019-05-03) 18794855;19648920;20348956;20972438;21750109;24163127;24861552 https://www.ncbi.nlm.nih.gov/pubmed/?term=18794855+19648920+20348956+20972438+21750109+24163127+24861552 15 1.4e-18 0.0151919 0.0821 0.571 0.555-0.588 OR 2.91 1.99-4.24 2.91 1.99-4.24 2.7 2.04-3.57 2.7 2.04-3.57 2.12 1.73-2.59 2.12 1.73-2.59 1.6 1.35-1.89 1.6 1.35-1.89 1.51 1.33-1.71 1.51 1.33-1.71 1.09 0.904-1.31 0.374 1.46 1.23-1.74 1.78e-05 1.79 1.51-2.12 1.43e-11 TRUE FALSE FALSE TRUE Both 1229 12301 GRCh37/hg19 P<=7e-07 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000613/ScoringFiles/ phewas/PRSWEB_PHECODE189.2_GWAS-Catalog-r2019-05-03-X189.2_PT_UKB_20200608/all.tsv phewas/PRSWEB_PHECODE189.2_GWAS-Catalog-r2019-05-03-X189.2_PT_UKB_20200608/exclusion.tsv 2020-06-08 prsweb-phecode190-20001-1030-p-5e-05-mgi-20200608 prsweb-phecode190-20001-1030-p-5e-05-mgi-20200608 PRSWEB_PHECODE190_20001-1030_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE190_20001-1030_P_5e-05_MGI_20200608 190 Cancer code, self-reported: eye and/or adnexal cancer Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 34 0.75 0.00725005 0.0837 0.492 0.414-0.565 OR 3.29 0.71-15.3 3.29 0.71-15.3 1.81 0.442-7.42 1.81 0.442-7.42 1.76 0.678-4.58 1.76 0.678-4.58 1.21 0.545-2.7 1.21 0.545-2.7 1.05 0.587-1.89 1.05 0.587-1.89 0.679 0.33-1.4 0.294 0.778 0.385-1.57 0.483 0.837 0.423-1.66 0.611 FALSE FALSE FALSE FALSE Both 62 610 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode190-c3-eye-adnexa-p-5e-05-mgi-20200608 prsweb-phecode190-c3-eye-adnexa-p-5e-05-mgi-20200608 PRSWEB_PHECODE190_C3-EYE-ADNEXA_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE190_C3-EYE-ADNEXA_P_5e-05_MGI_20200608 190 Malignant neoplasm of eye and adnexa Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 49 0.77 0.0070403 0.0837 0.501 0.425-0.577 OR 1.93 0.299-12.4 1.93 0.299-12.4 1.79 0.432-7.38 1.79 0.432-7.38 1.71 0.656-4.48 1.71 0.656-4.48 1.37 0.636-2.95 1.37 0.636-2.95 1.23 0.695-2.16 1.23 0.695-2.16 1.11 0.558-2.2 0.768 0.567 0.251-1.28 0.172 1.06 0.53-2.11 0.874 FALSE FALSE FALSE FALSE Both 62 610 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode190-c69-p-5e-05-mgi-20200608 prsweb-phecode190-c69-p-5e-05-mgi-20200608 PRSWEB_PHECODE190_C69_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE190_C69_P_5e-05_MGI_20200608 190 Diagnoses - main ICD10: C69 Malignant neoplasm of eye and adnexa Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 35 0.35 0.0029501 0.0837 0.534 0.464-0.611 OR 0 0-0 0 0-0 1.8 0.438-7.38 1.8 0.438-7.38 1.73 0.671-4.47 1.73 0.671-4.47 1.01 0.433-2.36 1.01 0.433-2.36 1.23 0.694-2.18 1.23 0.694-2.18 0.951 0.439-2.06 0.898 1.31 0.635-2.68 0.468 1.29 0.62-2.68 0.496 FALSE FALSE FALSE FALSE Both 62 610 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode190-ukbb-saige-hrc-x190-p-5e-05-mgi-20200608 prsweb-phecode190-ukbb-saige-hrc-x190-p-5e-05-mgi-20200608 PRSWEB_PHECODE190_UKBB-SAIGE-HRC-X190_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE190_UKBB-SAIGE-HRC-X190_P_5e-05_MGI_20200608 190 Cancer of eye Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 71 0.88 0.000952131 0.0837 0.486 0.403-0.56 OR 0 0-0 0 0-0 1.78 0.432-7.31 1.78 0.432-7.31 2.09 0.844-5.18 2.09 0.844-5.18 1.76 0.859-3.6 1.76 0.859-3.6 1.06 0.589-1.89 1.06 0.589-1.89 0.874 0.43-1.78 0.71 0.832 0.408-1.69 0.611 0.926 0.46-1.86 0.829 FALSE FALSE FALSE FALSE Both 62 610 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode190-c3-eye-adnexa-p-5e-06-mgi-20200608 prsweb-phecode190-c3-eye-adnexa-p-5e-06-mgi-20200608 PRSWEB_PHECODE190_C3-EYE-ADNEXA_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE190_C3-EYE-ADNEXA_P_5e-06_MGI_20200608 190 Malignant neoplasm of eye and adnexa Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 7 0.93 0.00213657 0.0837 0.496 0.417-0.571 OR 1.86 0.286-12.1 1.86 0.286-12.1 1.04 0.182-5.95 1.04 0.182-5.95 1.41 0.506-3.95 1.41 0.506-3.95 1.02 0.436-2.37 1.02 0.436-2.37 0.97 0.536-1.76 0.97 0.536-1.76 1.73 0.823-3.62 0.149 1.37 0.632-2.98 0.423 1.39 0.637-3.05 0.406 FALSE FALSE FALSE FALSE Both 62 610 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode190-c3-eye-adnexa-pt-mgi-20200608 prsweb-phecode190-c3-eye-adnexa-pt-mgi-20200608 PRSWEB_PHECODE190_C3-EYE-ADNEXA_PT_MGI_20200608 P&T PRSWEB_PHECODE190_C3-EYE-ADNEXA_PT_MGI_20200608 190 Malignant neoplasm of eye and adnexa Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative P&T UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 49 0.77 0.0070403 0.0837 0.501 0.425-0.577 OR 1.93 0.299-12.4 1.93 0.299-12.4 1.79 0.432-7.38 1.79 0.432-7.38 1.71 0.656-4.48 1.71 0.656-4.48 1.37 0.636-2.95 1.37 0.636-2.95 1.23 0.695-2.16 1.23 0.695-2.16 1.11 0.558-2.2 0.768 0.567 0.251-1.28 0.172 1.06 0.53-2.11 0.874 FALSE FALSE FALSE FALSE Both 62 610 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode190-20001-1030-prs-cs-mgi-20200608 prsweb-phecode190-20001-1030-prs-cs-mgi-20200608 PRSWEB_PHECODE190_20001-1030_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE190_20001-1030_PRS-CS_MGI_20200608 190 Cancer code, self-reported: eye and/or adnexal cancer Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative PRS-CS UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 834009 0.027 0.00347171 0.0831 0.586 0.508-0.658 OR 4.74 1.2-18.7 4.74 1.2-18.7 3.39 1.1-10.5 3.39 1.1-10.5 1.75 0.679-4.54 1.75 0.679-4.54 1.8 0.884-3.69 1.8 0.884-3.69 1.67 0.971-2.87 1.67 0.971-2.87 1.5 0.644-3.52 0.346 2.13 0.95-4.76 0.0665 2.6 1.17-5.77 0.0191 TRUE FALSE FALSE TRUE Both 62 610 GRCh37/hg19 auto https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000617/ScoringFiles/ phewas/PRSWEB_PHECODE190_20001-1030_PRS-CS_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE190_20001-1030_PRS-CS_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode190-c3-eye-adnexa-prs-cs-mgi-20200608 prsweb-phecode190-c3-eye-adnexa-prs-cs-mgi-20200608 PRSWEB_PHECODE190_C3-EYE-ADNEXA_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE190_C3-EYE-ADNEXA_PRS-CS_MGI_20200608 190 Malignant neoplasm of eye and adnexa Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative PRS-CS UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 849853 0.3 6.45946e-05 0.0836 0.546 0.47-0.622 OR 1.99 0.308-12.8 1.99 0.308-12.8 1.1 0.193-6.3 1.1 0.193-6.3 1.41 0.506-3.95 1.41 0.506-3.95 1.03 0.441-2.39 1.03 0.441-2.39 1.43 0.827-2.48 1.43 0.827-2.48 1.03 0.473-2.25 0.939 1.33 0.624-2.82 0.462 1.65 0.803-3.39 0.173 FALSE FALSE FALSE FALSE Both 62 610 GRCh37/hg19 auto 2020-06-08 prsweb-phecode190-c69-prs-cs-mgi-20200608 prsweb-phecode190-c69-prs-cs-mgi-20200608 PRSWEB_PHECODE190_C69_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE190_C69_PRS-CS_MGI_20200608 190 Diagnoses - main ICD10: C69 Malignant neoplasm of eye and adnexa Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative PRS-CS UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 911547 0.13 0.00109888 0.0834 0.545 0.47-0.613 OR 4.58 1.17-17.9 4.58 1.17-17.9 3.36 1.09-10.4 3.36 1.09-10.4 2.12 0.869-5.19 2.12 0.869-5.19 1.76 0.868-3.58 1.76 0.868-3.58 1.24 0.702-2.17 1.24 0.702-2.17 1.35 0.643-2.83 0.429 1.29 0.598-2.78 0.518 1.48 0.712-3.09 0.292 FALSE FALSE FALSE FALSE Both 62 610 GRCh37/hg19 auto 2020-06-08 prsweb-phecode190-ukbb-saige-hrc-x190-prs-cs-mgi-20200608 prsweb-phecode190-ukbb-saige-hrc-x190-prs-cs-mgi-20200608 PRSWEB_PHECODE190_UKBB-SAIGE-HRC-X190_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE190_UKBB-SAIGE-HRC-X190_PRS-CS_MGI_20200608 190 Cancer of eye Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative PRS-CS UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1119238 0.47 0.000165598 0.0837 0.53 0.459-0.603 OR 1.88 0.29-12.1 1.88 0.29-12.1 1.03 0.179-5.95 1.03 0.179-5.95 1.07 0.344-3.33 1.07 0.344-3.33 0.852 0.344-2.11 0.852 0.344-2.11 1.06 0.588-1.9 1.06 0.588-1.9 1.55 0.705-3.42 0.274 1.78 0.831-3.83 0.138 1.62 0.736-3.56 0.23 FALSE FALSE FALSE FALSE Both 62 610 GRCh37/hg19 auto 2020-06-08 prsweb-phecode190-20001-1030-lassosum-mgi-20200608 prsweb-phecode190-20001-1030-lassosum-mgi-20200608 PRSWEB_PHECODE190_20001-1030_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE190_20001-1030_LASSOSUM_MGI_20200608 190 Cancer code, self-reported: eye and/or adnexal cancer Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative lassosum UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 19193 0.15 0.00467078 0.0835 0.561 0.485-0.636 OR 0 0-0 0 0-0 1.88 0.458-7.75 1.88 0.458-7.75 1.43 0.512-3.97 1.43 0.512-3.97 1.21 0.545-2.71 1.21 0.545-2.71 1.44 0.829-2.5 1.44 0.829-2.5 0.667 0.295-1.5 0.329 1.47 0.716-3.01 0.295 1.39 0.696-2.78 0.35 FALSE FALSE FALSE FALSE Both 62 610 GRCh37/hg19 s=0.2;Lambda=0.1 2020-06-08 prsweb-phecode190-c3-eye-adnexa-lassosum-mgi-20200608 prsweb-phecode190-c3-eye-adnexa-lassosum-mgi-20200608 PRSWEB_PHECODE190_C3-EYE-ADNEXA_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE190_C3-EYE-ADNEXA_LASSOSUM_MGI_20200608 190 Malignant neoplasm of eye and adnexa Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative lassosum UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 195920 0.37 0.0146436 0.0837 0.534 0.456-0.608 OR 1.91 0.296-12.4 1.91 0.296-12.4 1.78 0.432-7.3 1.78 0.432-7.3 1.05 0.334-3.3 1.05 0.334-3.3 1.01 0.432-2.36 1.01 0.432-2.36 1.24 0.702-2.18 1.24 0.702-2.18 1.86 0.879-3.94 0.104 1.1 0.488-2.49 0.816 1.6 0.752-3.4 0.223 FALSE FALSE FALSE FALSE Both 62 610 GRCh37/hg19 s=0.5;Lambda=0.04833 2020-06-08 prsweb-phecode190-c69-lassosum-mgi-20200608 prsweb-phecode190-c69-lassosum-mgi-20200608 PRSWEB_PHECODE190_C69_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE190_C69_LASSOSUM_MGI_20200608 190 Diagnoses - main ICD10: C69 Malignant neoplasm of eye and adnexa Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative lassosum UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1496730 0.28 0.013048 0.0836 0.54 0.461-0.621 OR 1.82 0.268-12.4 1.82 0.268-12.4 1.76 0.412-7.5 1.76 0.412-7.5 2.14 0.863-5.33 2.14 0.863-5.33 2.01 1-4.04 2.01 1-4.04 1.65 0.96-2.84 1.65 0.96-2.84 0.835 0.406-1.72 0.623 0.528 0.238-1.17 0.116 1.31 0.679-2.51 0.424 FALSE FALSE FALSE FALSE Both 62 610 GRCh37/hg19 s=0.2;Lambda=0.004281 2020-06-08 prsweb-phecode190-ukbb-saige-hrc-x190-lassosum-mgi-20200608 prsweb-phecode190-ukbb-saige-hrc-x190-lassosum-mgi-20200608 PRSWEB_PHECODE190_UKBB-SAIGE-HRC-X190_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE190_UKBB-SAIGE-HRC-X190_LASSOSUM_MGI_20200608 190 Cancer of eye Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative lassosum UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 2397847 0.12 0.0110053 0.0834 0.547 0.473-0.62 OR 1.93 0.297-12.5 1.93 0.297-12.5 1.8 0.437-7.4 1.8 0.437-7.4 2.5 1.06-5.89 2.5 1.06-5.89 2.03 1.01-4.08 2.03 1.01-4.08 1.25 0.708-2.21 1.25 0.708-2.21 1.76 0.832-3.71 0.14 1.29 0.592-2.8 0.523 1.54 0.72-3.27 0.267 FALSE FALSE FALSE FALSE Both 62 610 GRCh37/hg19 s=0.5;Lambda=0.008859 2020-06-08 prsweb-phecode191-1-c3-eye-brain-neuro-p-5e-05-mgi-20200608 prsweb-phecode191-1-c3-eye-brain-neuro-p-5e-05-mgi-20200608 PRSWEB_PHECODE191.1_C3-EYE-BRAIN-NEURO_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE191.1_C3-EYE-BRAIN-NEURO_P_5e-05_MGI_20200608 191.1 Malignant neoplasm of eye, brain and central nervous system Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 105 0.086 0.000102431 0.0826 0.526 0.488-0.561 OR 1.22 0.394-3.79 1.22 0.394-3.79 0.989 0.406-2.41 0.989 0.406-2.41 0.978 0.551-1.73 0.978 0.551-1.73 1.29 0.883-1.88 1.29 0.883-1.88 1.24 0.944-1.63 1.24 0.944-1.63 1.06 0.738-1.53 0.749 1.15 0.805-1.65 0.438 1.34 0.944-1.89 0.102 FALSE FALSE FALSE FALSE Both 274 2740 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode191-1-gwas-catalog-r2019-05-03-x191-1-p-5e-05-mgi-20200608 prsweb-phecode191-1-gwas-catalog-r2019-05-03-x191-1-p-5e-05-mgi-20200608 PRSWEB_PHECODE191.1_GWAS-Catalog-r2019-05-03-X191.1_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE191.1_GWAS-Catalog-r2019-05-03-X191.1_P_5e-05_MGI_20200608 191.1 Glioma;Non-glioblastoma glioma;Glioma (high-grade) Binary 36 unique SNPs MGI Michigan Genomics Initiative Fixed threshold (5e-05) GWAS Catalog (2019-05-03) 19578366;19578367;21531791;22886559;24908248;26424050;28346443 https://www.ncbi.nlm.nih.gov/pubmed/?term=19578366+19578367+21531791+22886559+24908248+26424050+28346443 28 0.34 0.00725184 0.0826 0.51 0.474-0.545 OR 0.875 0.235-3.26 0.875 0.235-3.26 0.991 0.407-2.41 0.991 0.407-2.41 0.678 0.347-1.32 0.678 0.347-1.32 1.08 0.722-1.61 1.08 0.722-1.61 1.26 0.961-1.66 1.26 0.961-1.66 0.949 0.664-1.36 0.776 0.958 0.67-1.37 0.813 1.21 0.864-1.71 0.264 FALSE FALSE FALSE FALSE Both 274 2740 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode191-1-ukbb-saige-hrc-x191-1-p-5e-05-mgi-20200608 prsweb-phecode191-1-ukbb-saige-hrc-x191-1-p-5e-05-mgi-20200608 PRSWEB_PHECODE191.1_UKBB-SAIGE-HRC-X191.1_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE191.1_UKBB-SAIGE-HRC-X191.1_P_5e-05_MGI_20200608 191.1 Cancer of brain and nervous system Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 114 0.46 0.00301187 0.0826 0.506 0.472-0.54 OR 2.31 0.967-5.53 2.31 0.967-5.53 1.36 0.625-2.95 1.36 0.625-2.95 1.06 0.606-1.84 1.06 0.606-1.84 1.16 0.788-1.72 1.16 0.788-1.72 1.04 0.78-1.37 1.04 0.78-1.37 1.11 0.777-1.57 0.578 1.11 0.779-1.58 0.567 1.09 0.768-1.55 0.627 FALSE FALSE FALSE FALSE Both 274 2740 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode191-1-gwas-catalog-r2019-05-03-x191-1-p-5e-06-mgi-20200608 prsweb-phecode191-1-gwas-catalog-r2019-05-03-x191-1-p-5e-06-mgi-20200608 PRSWEB_PHECODE191.1_GWAS-Catalog-r2019-05-03-X191.1_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE191.1_GWAS-Catalog-r2019-05-03-X191.1_P_5e-06_MGI_20200608 191.1 Glioma;Non-glioblastoma glioma;Glioma (high-grade) Binary 36 unique SNPs MGI Michigan Genomics Initiative Fixed threshold (5e-06) GWAS Catalog (2019-05-03) 19578366;19578367;21531791;22886559;24908248;26424050;28346443 https://www.ncbi.nlm.nih.gov/pubmed/?term=19578366+19578367+21531791+22886559+24908248+26424050+28346443 28 0.34 0.00725184 0.0826 0.51 0.474-0.545 OR 0.875 0.235-3.26 0.875 0.235-3.26 0.991 0.407-2.41 0.991 0.407-2.41 0.678 0.347-1.32 0.678 0.347-1.32 1.08 0.722-1.61 1.08 0.722-1.61 1.26 0.961-1.66 1.26 0.961-1.66 0.949 0.664-1.36 0.776 0.958 0.67-1.37 0.813 1.21 0.864-1.71 0.264 FALSE FALSE FALSE FALSE Both 274 2740 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode191-1-ukbb-saige-hrc-x191-1-p-5e-06-mgi-20200608 prsweb-phecode191-1-ukbb-saige-hrc-x191-1-p-5e-06-mgi-20200608 PRSWEB_PHECODE191.1_UKBB-SAIGE-HRC-X191.1_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE191.1_UKBB-SAIGE-HRC-X191.1_P_5e-06_MGI_20200608 191.1 Cancer of brain and nervous system Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 17 0.015 0.000227147 0.0825 0.53 0.495-0.563 OR 1.22 0.393-3.78 1.22 0.393-3.78 1.17 0.514-2.68 1.17 0.514-2.68 1.37 0.827-2.26 1.37 0.827-2.26 1.12 0.753-1.66 1.12 0.753-1.66 1.26 0.963-1.66 1.26 0.963-1.66 1.05 0.718-1.53 0.812 1.41 0.985-2.01 0.0603 1.45 1.02-2.06 0.041 TRUE FALSE FALSE FALSE Both 274 2740 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode191-1-gwas-catalog-r2019-05-03-x191-1-p-5e-07-mgi-20200608 prsweb-phecode191-1-gwas-catalog-r2019-05-03-x191-1-p-5e-07-mgi-20200608 PRSWEB_PHECODE191.1_GWAS-Catalog-r2019-05-03-X191.1_P_5e-07_MGI_20200608 P_5e-07 PRSWEB_PHECODE191.1_GWAS-Catalog-r2019-05-03-X191.1_P_5e-07_MGI_20200608 191.1 Glioma;Non-glioblastoma glioma;Glioma (high-grade) Binary 36 unique SNPs MGI Michigan Genomics Initiative Fixed threshold (5e-07) GWAS Catalog (2019-05-03) 19578366;19578367;21531791;22886559;24908248;26424050;28346443 https://www.ncbi.nlm.nih.gov/pubmed/?term=19578366+19578367+21531791+22886559+24908248+26424050+28346443 25 0.3 0.00709871 0.0826 0.51 0.474-0.544 OR 1.23 0.397-3.81 1.23 0.397-3.81 0.99 0.407-2.41 0.99 0.407-2.41 0.679 0.348-1.33 0.679 0.348-1.33 1.16 0.785-1.72 1.16 0.785-1.72 1.24 0.943-1.63 1.24 0.943-1.63 1.01 0.715-1.44 0.934 0.88 0.612-1.26 0.488 1.2 0.851-1.68 0.302 FALSE FALSE FALSE FALSE Both 274 2740 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode191-1-gwas-catalog-r2019-05-03-x191-1-p-5e-09-mgi-20200608 prsweb-phecode191-1-gwas-catalog-r2019-05-03-x191-1-p-5e-09-mgi-20200608 PRSWEB_PHECODE191.1_GWAS-Catalog-r2019-05-03-X191.1_P_5e-09_MGI_20200608 P_5e-09 PRSWEB_PHECODE191.1_GWAS-Catalog-r2019-05-03-X191.1_P_5e-09_MGI_20200608 191.1 Glioma;Non-glioblastoma glioma;Glioma (high-grade) Binary 36 unique SNPs MGI Michigan Genomics Initiative Fixed threshold (5e-09) GWAS Catalog (2019-05-03) 19578366;19578367;21531791;22886559;24908248;26424050;28346443 https://www.ncbi.nlm.nih.gov/pubmed/?term=19578366+19578367+21531791+22886559+24908248+26424050+28346443 20 0.58 0.00473546 0.0826 0.501 0.465-0.535 OR 0.873 0.234-3.25 0.873 0.234-3.25 1.17 0.511-2.67 1.17 0.511-2.67 0.976 0.55-1.73 0.976 0.55-1.73 1.12 0.753-1.66 1.12 0.753-1.66 1.07 0.809-1.42 1.07 0.809-1.42 0.75 0.524-1.07 0.115 0.92 0.653-1.29 0.631 0.965 0.688-1.35 0.839 FALSE FALSE FALSE FALSE Both 274 2740 GRCh37/hg19 P<=5e-09 2020-06-08 prsweb-phecode191-1-gwas-catalog-r2019-05-03-x191-1-p-5e-08-mgi-20200608 prsweb-phecode191-1-gwas-catalog-r2019-05-03-x191-1-p-5e-08-mgi-20200608 PRSWEB_PHECODE191.1_GWAS-Catalog-r2019-05-03-X191.1_P_5e-08_MGI_20200608 P_5e-08 PRSWEB_PHECODE191.1_GWAS-Catalog-r2019-05-03-X191.1_P_5e-08_MGI_20200608 191.1 Glioma;Non-glioblastoma glioma;Glioma (high-grade) Binary 36 unique SNPs MGI Michigan Genomics Initiative GWAS Hits GWAS Catalog (2019-05-03) 19578366;19578367;21531791;22886559;24908248;26424050;28346443 https://www.ncbi.nlm.nih.gov/pubmed/?term=19578366+19578367+21531791+22886559+24908248+26424050+28346443 23 0.28 0.00579417 0.0826 0.511 0.476-0.546 OR 0.872 0.234-3.25 0.872 0.234-3.25 0.993 0.408-2.41 0.993 0.408-2.41 0.903 0.499-1.63 0.903 0.499-1.63 1.12 0.752-1.66 1.12 0.752-1.66 1.13 0.857-1.5 1.13 0.857-1.5 1.09 0.767-1.55 0.627 1.01 0.706-1.45 0.956 1.17 0.824-1.66 0.383 FALSE FALSE FALSE FALSE Both 274 2740 GRCh37/hg19 P<=5e-08 2020-06-08 prsweb-phecode191-1-c3-eye-brain-neuro-pt-mgi-20200608 prsweb-phecode191-1-c3-eye-brain-neuro-pt-mgi-20200608 PRSWEB_PHECODE191.1_C3-EYE-BRAIN-NEURO_PT_MGI_20200608 P&T PRSWEB_PHECODE191.1_C3-EYE-BRAIN-NEURO_PT_MGI_20200608 191.1 Malignant neoplasm of eye, brain and central nervous system Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative P&T UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 36 0.38 0.000490337 0.0826 0.508 0.47-0.543 OR 0 0-0 0 0-0 0.623 0.209-1.86 0.623 0.209-1.86 1.29 0.77-2.15 1.29 0.77-2.15 1.33 0.917-1.94 1.33 0.917-1.94 1.16 0.878-1.53 1.16 0.878-1.53 0.802 0.564-1.14 0.219 0.836 0.59-1.18 0.313 1 0.718-1.4 0.985 FALSE FALSE FALSE FALSE Both 274 2740 GRCh37/hg19 P<=1.26e-05 2020-06-08 prsweb-phecode191-1-gwas-catalog-r2019-05-03-x191-1-pt-mgi-20200608 prsweb-phecode191-1-gwas-catalog-r2019-05-03-x191-1-pt-mgi-20200608 PRSWEB_PHECODE191.1_GWAS-Catalog-r2019-05-03-X191.1_PT_MGI_20200608 P&T PRSWEB_PHECODE191.1_GWAS-Catalog-r2019-05-03-X191.1_PT_MGI_20200608 191.1 Glioma;Non-glioblastoma glioma;Glioma (high-grade) Binary 36 unique SNPs MGI Michigan Genomics Initiative P&T GWAS Catalog (2019-05-03) 19578366;19578367;21531791;22886559;24908248;26424050;28346443 https://www.ncbi.nlm.nih.gov/pubmed/?term=19578366+19578367+21531791+22886559+24908248+26424050+28346443 28 0.34 0.00725184 0.0826 0.51 0.474-0.545 OR 0.875 0.235-3.26 0.875 0.235-3.26 0.991 0.407-2.41 0.991 0.407-2.41 0.678 0.347-1.32 0.678 0.347-1.32 1.08 0.722-1.61 1.08 0.722-1.61 1.26 0.961-1.66 1.26 0.961-1.66 0.949 0.664-1.36 0.776 0.958 0.67-1.37 0.813 1.21 0.864-1.71 0.264 FALSE FALSE FALSE FALSE Both 274 2740 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode191-1-c3-eye-brain-neuro-prs-cs-mgi-20200608 prsweb-phecode191-1-c3-eye-brain-neuro-prs-cs-mgi-20200608 PRSWEB_PHECODE191.1_C3-EYE-BRAIN-NEURO_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE191.1_C3-EYE-BRAIN-NEURO_PRS-CS_MGI_20200608 191.1 Malignant neoplasm of eye, brain and central nervous system Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative PRS-CS UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1072894 0.22 0.000842839 0.0826 0.526 0.49-0.562 OR 0.876 0.235-3.27 0.876 0.235-3.27 0.996 0.409-2.43 0.996 0.409-2.43 1.22 0.718-2.06 1.22 0.718-2.06 0.962 0.633-1.46 0.962 0.633-1.46 1.1 0.829-1.45 1.1 0.829-1.45 1.23 0.854-1.76 0.268 1.31 0.914-1.87 0.142 1.29 0.899-1.84 0.167 FALSE FALSE FALSE FALSE Both 274 2740 GRCh37/hg19 auto 2020-06-08 prsweb-phecode191-1-ukbb-saige-hrc-x191-1-lassosum-mgi-20200608 prsweb-phecode191-1-ukbb-saige-hrc-x191-1-lassosum-mgi-20200608 PRSWEB_PHECODE191.1_UKBB-SAIGE-HRC-X191.1_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE191.1_UKBB-SAIGE-HRC-X191.1_LASSOSUM_MGI_20200608 191.1 Cancer of brain and nervous system Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative lassosum UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 43 0.28 0.00796085 0.0826 0.506 0.47-0.538 OR 1.23 0.396-3.8 1.23 0.396-3.8 1.17 0.512-2.67 1.17 0.512-2.67 1.44 0.88-2.35 1.44 0.88-2.35 1.29 0.882-1.88 1.29 0.882-1.88 0.993 0.746-1.32 0.993 0.746-1.32 1.26 0.885-1.8 0.199 1.19 0.834-1.7 0.338 1.13 0.788-1.62 0.507 FALSE FALSE FALSE FALSE Both 274 2740 GRCh37/hg19 s=0.5;Lambda=0.1 2020-06-08 prsweb-phecode191-1-gwas-catalog-r2019-05-03-x191-1-p-5e-05-ukb-20200608 prsweb-phecode191-1-gwas-catalog-r2019-05-03-x191-1-p-5e-05-ukb-20200608 PRSWEB_PHECODE191.1_GWAS-Catalog-r2019-05-03-X191.1_P_5e-05_UKB_20200608 P_5e-05 PRSWEB_PHECODE191.1_GWAS-Catalog-r2019-05-03-X191.1_P_5e-05_UKB_20200608 191.1 Glioma;Non-glioblastoma glioma;Glioma (high-grade) Binary 36 unique SNPs UKB UK Biobank Fixed threshold (5e-05) GWAS Catalog (2019-05-03) 19578366;19578367;21531791;22886559;24908248;26424050;28346443 https://www.ncbi.nlm.nih.gov/pubmed/?term=19578366+19578367+21531791+22886559+24908248+26424050+28346443 28 5.6e-15 0.0257529 0.0811 0.625 0.592-0.656 OR 3.65 1.77-7.56 3.65 1.77-7.56 2.6 1.43-4.71 2.6 1.43-4.71 2.35 1.56-3.53 2.35 1.56-3.53 2.69 1.99-3.64 2.69 1.99-3.64 2.15 1.67-2.76 2.15 1.67-2.76 1.83 1.17-2.87 0.00812 2.68 1.75-4.1 5.98e-06 3.87 2.57-5.83 8.85e-11 TRUE FALSE FALSE FALSE Both 283 2827 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode191-1-gwas-catalog-r2019-05-03-x191-1-p-5e-06-ukb-20200608 prsweb-phecode191-1-gwas-catalog-r2019-05-03-x191-1-p-5e-06-ukb-20200608 PRSWEB_PHECODE191.1_GWAS-Catalog-r2019-05-03-X191.1_P_5e-06_UKB_20200608 P_5e-06 PRSWEB_PHECODE191.1_GWAS-Catalog-r2019-05-03-X191.1_P_5e-06_UKB_20200608 191.1 Glioma;Non-glioblastoma glioma;Glioma (high-grade) Binary 36 unique SNPs UKB UK Biobank Fixed threshold (5e-06) GWAS Catalog (2019-05-03) 19578366;19578367;21531791;22886559;24908248;26424050;28346443 https://www.ncbi.nlm.nih.gov/pubmed/?term=19578366+19578367+21531791+22886559+24908248+26424050+28346443 28 5.6e-15 0.0257529 0.0811 0.625 0.592-0.656 OR 3.65 1.77-7.56 3.65 1.77-7.56 2.6 1.43-4.71 2.6 1.43-4.71 2.35 1.56-3.53 2.35 1.56-3.53 2.69 1.99-3.64 2.69 1.99-3.64 2.15 1.67-2.76 2.15 1.67-2.76 1.83 1.17-2.87 0.00812 2.68 1.75-4.1 5.98e-06 3.87 2.57-5.83 8.85e-11 TRUE FALSE FALSE FALSE Both 283 2827 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode191-1-gwas-catalog-r2019-05-03-x191-1-p-5e-07-ukb-20200608 prsweb-phecode191-1-gwas-catalog-r2019-05-03-x191-1-p-5e-07-ukb-20200608 PRSWEB_PHECODE191.1_GWAS-Catalog-r2019-05-03-X191.1_P_5e-07_UKB_20200608 P_5e-07 PRSWEB_PHECODE191.1_GWAS-Catalog-r2019-05-03-X191.1_P_5e-07_UKB_20200608 191.1 Glioma;Non-glioblastoma glioma;Glioma (high-grade) Binary 36 unique SNPs UKB UK Biobank Fixed threshold (5e-07) GWAS Catalog (2019-05-03) 19578366;19578367;21531791;22886559;24908248;26424050;28346443 https://www.ncbi.nlm.nih.gov/pubmed/?term=19578366+19578367+21531791+22886559+24908248+26424050+28346443 25 2.9e-15 0.0274932 0.0811 0.628 0.595-0.659 OR 3.29 1.55-6.99 3.29 1.55-6.99 2.22 1.18-4.17 2.22 1.18-4.17 2.69 1.82-3.97 2.69 1.82-3.97 2.32 1.7-3.18 2.32 1.7-3.18 2.27 1.77-2.92 2.27 1.77-2.92 1.91 1.22-2.98 0.0043 2.43 1.58-3.74 5.15e-05 3.97 2.64-5.96 3.33e-11 TRUE FALSE FALSE FALSE Both 283 2827 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode191-1-gwas-catalog-r2019-05-03-x191-1-p-5e-09-ukb-20200608 prsweb-phecode191-1-gwas-catalog-r2019-05-03-x191-1-p-5e-09-ukb-20200608 PRSWEB_PHECODE191.1_GWAS-Catalog-r2019-05-03-X191.1_P_5e-09_UKB_20200608 P_5e-09 PRSWEB_PHECODE191.1_GWAS-Catalog-r2019-05-03-X191.1_P_5e-09_UKB_20200608 191.1 Glioma;Non-glioblastoma glioma;Glioma (high-grade) Binary 36 unique SNPs UKB UK Biobank Fixed threshold (5e-09) GWAS Catalog (2019-05-03) 19578366;19578367;21531791;22886559;24908248;26424050;28346443 https://www.ncbi.nlm.nih.gov/pubmed/?term=19578366+19578367+21531791+22886559+24908248+26424050+28346443 20 3.8e-14 0.0308939 0.0812 0.619 0.586-0.65 OR 3.64 1.76-7.52 3.64 1.76-7.52 2.6 1.43-4.7 2.6 1.43-4.7 2.52 1.69-3.76 2.52 1.69-3.76 2.23 1.62-3.06 2.23 1.62-3.06 2.09 1.62-2.68 2.09 1.62-2.68 1.84 1.18-2.86 0.00684 2.55 1.67-3.89 1.42e-05 3.66 2.44-5.49 3.35e-10 TRUE FALSE FALSE FALSE Both 283 2827 GRCh37/hg19 P<=5e-09 2020-06-08 prsweb-phecode191-1-gwas-catalog-r2019-05-03-x191-1-p-5e-08-ukb-20200608 prsweb-phecode191-1-gwas-catalog-r2019-05-03-x191-1-p-5e-08-ukb-20200608 PRSWEB_PHECODE191.1_GWAS-Catalog-r2019-05-03-X191.1_P_5e-08_UKB_20200608 P_5e-08 PRSWEB_PHECODE191.1_GWAS-Catalog-r2019-05-03-X191.1_P_5e-08_UKB_20200608 191.1 Glioma;Non-glioblastoma glioma;Glioma (high-grade) Binary 36 unique SNPs UKB UK Biobank GWAS Hits GWAS Catalog (2019-05-03) 19578366;19578367;21531791;22886559;24908248;26424050;28346443 https://www.ncbi.nlm.nih.gov/pubmed/?term=19578366+19578367+21531791+22886559+24908248+26424050+28346443 23 1.4e-14 0.0276336 0.0812 0.623 0.592-0.656 OR 3.64 1.76-7.53 3.64 1.76-7.53 2.41 1.31-4.44 2.41 1.31-4.44 2.86 1.95-4.2 2.86 1.95-4.2 2.23 1.62-3.06 2.23 1.62-3.06 2.05 1.6-2.64 2.05 1.6-2.64 1.4 0.903-2.17 0.133 2.38 1.59-3.56 2.39e-05 3.3 2.24-4.87 1.77e-09 TRUE FALSE FALSE TRUE Both 283 2827 GRCh37/hg19 P<=5e-08 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000618/ScoringFiles/ phewas/PRSWEB_PHECODE191.1_GWAS-Catalog-r2019-05-03-X191.1_P_5e-08_UKB_20200608/all.tsv phewas/PRSWEB_PHECODE191.1_GWAS-Catalog-r2019-05-03-X191.1_P_5e-08_UKB_20200608/exclusion.tsv 2020-06-08 prsweb-phecode191-1-gwas-catalog-r2019-05-03-x191-1-pt-ukb-20200608 prsweb-phecode191-1-gwas-catalog-r2019-05-03-x191-1-pt-ukb-20200608 PRSWEB_PHECODE191.1_GWAS-Catalog-r2019-05-03-X191.1_PT_UKB_20200608 P&T PRSWEB_PHECODE191.1_GWAS-Catalog-r2019-05-03-X191.1_PT_UKB_20200608 191.1 Glioma;Non-glioblastoma glioma;Glioma (high-grade) Binary 36 unique SNPs UKB UK Biobank P&T GWAS Catalog (2019-05-03) 19578366;19578367;21531791;22886559;24908248;26424050;28346443 https://www.ncbi.nlm.nih.gov/pubmed/?term=19578366+19578367+21531791+22886559+24908248+26424050+28346443 19 1.3e-14 0.0314623 0.0812 0.622 0.59-0.653 OR 2.93 1.34-6.41 2.93 1.34-6.41 2.04 1.06-3.9 2.04 1.06-3.9 2.35 1.56-3.54 2.35 1.56-3.54 2.18 1.59-3 2.18 1.59-3 2.18 1.7-2.8 2.18 1.7-2.8 2.14 1.38-3.32 0.000687 2.34 1.52-3.62 0.000118 3.85 2.56-5.8 9.92e-11 TRUE FALSE FALSE TRUE Both 283 2827 GRCh37/hg19 P<=3.16e-09 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000619/ScoringFiles/ phewas/PRSWEB_PHECODE191.1_GWAS-Catalog-r2019-05-03-X191.1_PT_UKB_20200608/all.tsv phewas/PRSWEB_PHECODE191.1_GWAS-Catalog-r2019-05-03-X191.1_PT_UKB_20200608/exclusion.tsv 2020-06-08 prsweb-phecode191-11-20001-1032-p-5e-05-mgi-20200608 prsweb-phecode191-11-20001-1032-p-5e-05-mgi-20200608 PRSWEB_PHECODE191.11_20001-1032_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE191.11_20001-1032_P_5e-05_MGI_20200608 191.11 Cancer code, self-reported: brain cancer / primary malignant brain tumour Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 47 0.69 4.51008e-05 0.0826 0.509 0.469-0.549 OR 0 0-0 0 0-0 0.924 0.346-2.47 0.924 0.346-2.47 1.05 0.579-1.92 1.05 0.579-1.92 1.24 0.821-1.88 1.24 0.821-1.88 1.14 0.84-1.53 1.14 0.84-1.53 0.967 0.654-1.43 0.866 1.11 0.763-1.63 0.575 1.16 0.794-1.69 0.448 FALSE FALSE FALSE FALSE Both 233 2330 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode191-11-c71-p-5e-05-mgi-20200608 prsweb-phecode191-11-c71-p-5e-05-mgi-20200608 PRSWEB_PHECODE191.11_C71_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE191.11_C71_P_5e-05_MGI_20200608 191.11 Diagnoses - main ICD10: C71 Malignant neoplasm of brain Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 89 0.094 0.000450366 0.0825 0.522 0.481-0.559 OR 2.62 1.08-6.39 2.62 1.08-6.39 1.79 0.845-3.78 1.79 0.845-3.78 1.99 1.24-3.19 1.99 1.24-3.19 1.45 0.975-2.15 1.45 0.975-2.15 1.12 0.827-1.51 1.12 0.827-1.51 1.05 0.713-1.54 0.816 1.06 0.72-1.55 0.782 1.15 0.791-1.68 0.461 FALSE FALSE FALSE FALSE Both 233 2330 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode191-11-gwas-catalog-r2019-05-03-x191-11-p-5e-05-mgi-20200608 prsweb-phecode191-11-gwas-catalog-r2019-05-03-x191-11-p-5e-05-mgi-20200608 PRSWEB_PHECODE191.11_GWAS-Catalog-r2019-05-03-X191.11_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE191.11_GWAS-Catalog-r2019-05-03-X191.11_P_5e-05_MGI_20200608 191.11 Glioblastoma Binary 15 unique SNPs MGI Michigan Genomics Initiative Fixed threshold (5e-05) GWAS Catalog (2019-05-03) 22472174;26424050;28346443 https://www.ncbi.nlm.nih.gov/pubmed/?term=22472174+26424050+28346443 15 0.062 0.002808 0.0825 0.532 0.494-0.57 OR 1.01 0.268-3.8 1.01 0.268-3.8 0.724 0.242-2.17 0.724 0.242-2.17 1.33 0.772-2.31 1.33 0.772-2.31 1.3 0.863-1.95 1.3 0.863-1.95 1.19 0.884-1.61 1.19 0.884-1.61 1.16 0.783-1.73 0.454 1.28 0.864-1.88 0.22 1.36 0.923-2 0.121 FALSE FALSE FALSE FALSE Both 233 2330 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode191-11-ukbb-saige-hrc-x191-11-p-5e-05-mgi-20200608 prsweb-phecode191-11-ukbb-saige-hrc-x191-11-p-5e-05-mgi-20200608 PRSWEB_PHECODE191.11_UKBB-SAIGE-HRC-X191.11_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE191.11_UKBB-SAIGE-HRC-X191.11_P_5e-05_MGI_20200608 191.11 Cancer of brain Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 94 0.39 0.00160506 0.0826 0.513 0.474-0.55 OR 1.01 0.269-3.82 1.01 0.269-3.82 1.58 0.721-3.48 1.58 0.721-3.48 1.06 0.581-1.93 1.06 0.581-1.93 0.948 0.601-1.49 0.948 0.601-1.49 1.09 0.803-1.48 1.09 0.803-1.48 1.4 0.944-2.09 0.0935 1.48 0.995-2.2 0.0528 1.36 0.914-2.03 0.129 FALSE FALSE FALSE FALSE Both 233 2330 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode191-11-20001-1032-p-5e-06-mgi-20200608 prsweb-phecode191-11-20001-1032-p-5e-06-mgi-20200608 PRSWEB_PHECODE191.11_20001-1032_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE191.11_20001-1032_P_5e-06_MGI_20200608 191.11 Cancer code, self-reported: brain cancer / primary malignant brain tumour Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 7 0.79 7.02745e-05 0.0826 0.503 0.461-0.542 OR 0.978 0.258-3.7 0.978 0.258-3.7 1.12 0.454-2.76 1.12 0.454-2.76 0.955 0.512-1.78 0.955 0.512-1.78 1.04 0.67-1.61 1.04 0.67-1.61 1.11 0.818-1.5 1.11 0.818-1.5 1.14 0.772-1.68 0.511 1.14 0.771-1.67 0.52 1.2 0.816-1.76 0.358 FALSE FALSE FALSE FALSE Both 233 2330 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode191-11-c3-brain-p-5e-06-mgi-20200608 prsweb-phecode191-11-c3-brain-p-5e-06-mgi-20200608 PRSWEB_PHECODE191.11_C3-BRAIN_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE191.11_C3-BRAIN_P_5e-06_MGI_20200608 191.11 Malignant neoplasm of brain Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 16 0.82 0.000111995 0.0826 0.498 0.461-0.536 OR 0 0-0 0 0-0 0.102 0.00624-1.67 0.102 0.00624-1.67 0.703 0.346-1.43 0.703 0.346-1.43 0.861 0.537-1.38 0.861 0.537-1.38 0.997 0.732-1.36 0.997 0.732-1.36 1 0.686-1.47 0.984 1.06 0.725-1.54 0.772 1.01 0.692-1.48 0.952 FALSE FALSE FALSE FALSE Both 233 2330 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode191-11-c71-p-5e-06-mgi-20200608 prsweb-phecode191-11-c71-p-5e-06-mgi-20200608 PRSWEB_PHECODE191.11_C71_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE191.11_C71_P_5e-06_MGI_20200608 191.11 Diagnoses - main ICD10: C71 Malignant neoplasm of brain Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 15 0.0097 0.00131584 0.0824 0.541 0.5-0.582 OR 3.56 1.59-7.96 3.56 1.59-7.96 2.05 1-4.19 2.05 1-4.19 1.15 0.643-2.05 1.15 0.643-2.05 1.88 1.3-2.7 1.88 1.3-2.7 1.27 0.944-1.7 1.27 0.944-1.7 1.22 0.817-1.81 0.334 1.27 0.859-1.89 0.23 1.5 1.02-2.2 0.0394 TRUE FALSE FALSE FALSE Both 233 2330 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode191-11-gwas-catalog-r2019-05-03-x191-11-p-5e-06-mgi-20200608 prsweb-phecode191-11-gwas-catalog-r2019-05-03-x191-11-p-5e-06-mgi-20200608 PRSWEB_PHECODE191.11_GWAS-Catalog-r2019-05-03-X191.11_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE191.11_GWAS-Catalog-r2019-05-03-X191.11_P_5e-06_MGI_20200608 191.11 Glioblastoma Binary 15 unique SNPs MGI Michigan Genomics Initiative Fixed threshold (5e-06) GWAS Catalog (2019-05-03) 22472174;26424050;28346443 https://www.ncbi.nlm.nih.gov/pubmed/?term=22472174+26424050+28346443 14 0.062 0.00340651 0.0825 0.532 0.494-0.57 OR 0.599 0.112-3.2 0.599 0.112-3.2 0.515 0.143-1.86 0.515 0.143-1.86 1.52 0.903-2.56 1.52 0.903-2.56 1.25 0.824-1.89 1.25 0.824-1.89 1.19 0.884-1.61 1.19 0.884-1.61 1.19 0.796-1.77 0.401 1.32 0.891-1.95 0.168 1.4 0.949-2.06 0.09 FALSE FALSE FALSE FALSE Both 233 2330 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode191-11-ukbb-saige-hrc-x191-11-p-5e-06-mgi-20200608 prsweb-phecode191-11-ukbb-saige-hrc-x191-11-p-5e-06-mgi-20200608 PRSWEB_PHECODE191.11_UKBB-SAIGE-HRC-X191.11_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE191.11_UKBB-SAIGE-HRC-X191.11_P_5e-06_MGI_20200608 191.11 Cancer of brain Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 14 0.016 0.00337569 0.0824 0.534 0.495-0.574 OR 1.41 0.45-4.44 1.41 0.45-4.44 1.81 0.857-3.82 1.81 0.857-3.82 1.33 0.771-2.3 1.33 0.771-2.3 1.09 0.711-1.69 1.09 0.711-1.69 1.43 1.07-1.91 1.43 1.07-1.91 0.837 0.559-1.25 0.386 1.02 0.694-1.49 0.926 1.36 0.947-1.96 0.0961 TRUE FALSE FALSE FALSE Both 233 2330 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode191-11-c3-brain-p-5e-07-mgi-20200608 prsweb-phecode191-11-c3-brain-p-5e-07-mgi-20200608 PRSWEB_PHECODE191.11_C3-BRAIN_P_5e-07_MGI_20200608 P_5e-07 PRSWEB_PHECODE191.11_C3-BRAIN_P_5e-07_MGI_20200608 191.11 Malignant neoplasm of brain Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-07) UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 6 0.084 0.000256754 0.0825 0.534 0.497-0.572 OR 1.01 0.268-3.82 1.01 0.268-3.82 0.721 0.24-2.16 0.721 0.24-2.16 0.707 0.348-1.44 0.707 0.348-1.44 0.903 0.568-1.44 0.903 0.568-1.44 1.34 1-1.8 1.34 1-1.8 1.29 0.869-1.92 0.204 1.21 0.81-1.81 0.351 1.56 1.06-2.29 0.0233 FALSE FALSE FALSE FALSE Both 233 2330 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode191-11-gwas-catalog-r2019-05-03-x191-11-p-5e-07-mgi-20200608 prsweb-phecode191-11-gwas-catalog-r2019-05-03-x191-11-p-5e-07-mgi-20200608 PRSWEB_PHECODE191.11_GWAS-Catalog-r2019-05-03-X191.11_P_5e-07_MGI_20200608 P_5e-07 PRSWEB_PHECODE191.11_GWAS-Catalog-r2019-05-03-X191.11_P_5e-07_MGI_20200608 191.11 Glioblastoma Binary 15 unique SNPs MGI Michigan Genomics Initiative Fixed threshold (5e-07) GWAS Catalog (2019-05-03) 22472174;26424050;28346443 https://www.ncbi.nlm.nih.gov/pubmed/?term=22472174+26424050+28346443 12 0.03 0.00340919 0.0825 0.54 0.503-0.579 OR 1.02 0.271-3.86 1.02 0.271-3.86 1.36 0.59-3.14 1.36 0.59-3.14 1.34 0.773-2.31 1.34 0.773-2.31 1.5 1.02-2.22 1.5 1.02-2.22 1.14 0.845-1.54 1.14 0.845-1.54 0.965 0.639-1.46 0.865 1.49 1.02-2.17 0.0382 1.28 0.87-1.88 0.209 TRUE FALSE FALSE FALSE Both 233 2330 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode191-11-gwas-catalog-r2019-05-03-x191-11-p-5e-09-mgi-20200608 prsweb-phecode191-11-gwas-catalog-r2019-05-03-x191-11-p-5e-09-mgi-20200608 PRSWEB_PHECODE191.11_GWAS-Catalog-r2019-05-03-X191.11_P_5e-09_MGI_20200608 P_5e-09 PRSWEB_PHECODE191.11_GWAS-Catalog-r2019-05-03-X191.11_P_5e-09_MGI_20200608 191.11 Glioblastoma Binary 15 unique SNPs MGI Michigan Genomics Initiative Fixed threshold (5e-09) GWAS Catalog (2019-05-03) 22472174;26424050;28346443 https://www.ncbi.nlm.nih.gov/pubmed/?term=22472174+26424050+28346443 11 0.035 0.00344775 0.0825 0.538 0.501-0.577 OR 0.602 0.113-3.22 0.602 0.113-3.22 0.935 0.351-2.49 0.935 0.351-2.49 1.24 0.707-2.18 1.24 0.707-2.18 1.3 0.862-1.95 1.3 0.862-1.95 1.29 0.964-1.73 1.29 0.964-1.73 0.957 0.639-1.43 0.833 1.24 0.848-1.82 0.266 1.34 0.918-1.95 0.131 TRUE FALSE FALSE FALSE Both 233 2330 GRCh37/hg19 P<=5e-09 2020-06-08 prsweb-phecode191-11-gwas-catalog-r2019-05-03-x191-11-p-5e-08-mgi-20200608 prsweb-phecode191-11-gwas-catalog-r2019-05-03-x191-11-p-5e-08-mgi-20200608 PRSWEB_PHECODE191.11_GWAS-Catalog-r2019-05-03-X191.11_P_5e-08_MGI_20200608 P_5e-08 PRSWEB_PHECODE191.11_GWAS-Catalog-r2019-05-03-X191.11_P_5e-08_MGI_20200608 191.11 Glioblastoma Binary 15 unique SNPs MGI Michigan Genomics Initiative GWAS Hits GWAS Catalog (2019-05-03) 22472174;26424050;28346443 https://www.ncbi.nlm.nih.gov/pubmed/?term=22472174+26424050+28346443 12 0.03 0.00340919 0.0825 0.54 0.503-0.579 OR 1.02 0.271-3.86 1.02 0.271-3.86 1.36 0.59-3.14 1.36 0.59-3.14 1.34 0.773-2.31 1.34 0.773-2.31 1.5 1.02-2.22 1.5 1.02-2.22 1.14 0.845-1.54 1.14 0.845-1.54 0.965 0.639-1.46 0.865 1.49 1.02-2.17 0.0382 1.28 0.87-1.88 0.209 TRUE FALSE FALSE TRUE Both 233 2330 GRCh37/hg19 P<=5e-08 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000621/ScoringFiles/ phewas/PRSWEB_PHECODE191.11_GWAS-Catalog-r2019-05-03-X191.11_P_5e-08_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE191.11_GWAS-Catalog-r2019-05-03-X191.11_P_5e-08_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode191-11-20001-1032-pt-mgi-20200608 prsweb-phecode191-11-20001-1032-pt-mgi-20200608 PRSWEB_PHECODE191.11_20001-1032_PT_MGI_20200608 P&T PRSWEB_PHECODE191.11_20001-1032_PT_MGI_20200608 191.11 Cancer code, self-reported: brain cancer / primary malignant brain tumour Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative P&T UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 82 0.46 0.000524096 0.0826 0.512 0.473-0.55 OR 0.603 0.113-3.22 0.603 0.113-3.22 1.58 0.72-3.47 1.58 0.72-3.47 1.51 0.899-2.55 1.51 0.899-2.55 1.14 0.746-1.75 1.14 0.746-1.75 1.21 0.9-1.63 1.21 0.9-1.63 0.941 0.639-1.39 0.76 0.968 0.66-1.42 0.867 1.18 0.818-1.71 0.374 FALSE FALSE FALSE FALSE Both 233 2330 GRCh37/hg19 P<=7.94e-05 2020-06-08 prsweb-phecode191-11-c71-pt-mgi-20200608 prsweb-phecode191-11-c71-pt-mgi-20200608 PRSWEB_PHECODE191.11_C71_PT_MGI_20200608 P&T PRSWEB_PHECODE191.11_C71_PT_MGI_20200608 191.11 Diagnoses - main ICD10: C71 Malignant neoplasm of brain Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative P&T UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 29 0.12 0.00332215 0.0825 0.528 0.486-0.571 OR 2.26 0.875-5.84 2.26 0.875-5.84 1.8 0.852-3.81 1.8 0.852-3.81 0.971 0.521-1.81 0.971 0.521-1.81 1.05 0.677-1.63 1.05 0.677-1.63 1.22 0.903-1.64 1.22 0.903-1.64 0.788 0.525-1.18 0.252 1.16 0.801-1.68 0.429 1.2 0.827-1.74 0.34 FALSE FALSE FALSE FALSE Both 233 2330 GRCh37/hg19 P<=1.26e-05 2020-06-08 prsweb-phecode191-11-gwas-catalog-r2019-05-03-x191-11-pt-mgi-20200608 prsweb-phecode191-11-gwas-catalog-r2019-05-03-x191-11-pt-mgi-20200608 PRSWEB_PHECODE191.11_GWAS-Catalog-r2019-05-03-X191.11_PT_MGI_20200608 P&T PRSWEB_PHECODE191.11_GWAS-Catalog-r2019-05-03-X191.11_PT_MGI_20200608 191.11 Glioblastoma Binary 15 unique SNPs MGI Michigan Genomics Initiative P&T GWAS Catalog (2019-05-03) 22472174;26424050;28346443 https://www.ncbi.nlm.nih.gov/pubmed/?term=22472174+26424050+28346443 11 0.035 0.00344775 0.0825 0.538 0.501-0.577 OR 0.602 0.113-3.22 0.602 0.113-3.22 0.935 0.351-2.49 0.935 0.351-2.49 1.24 0.707-2.18 1.24 0.707-2.18 1.3 0.862-1.95 1.3 0.862-1.95 1.29 0.964-1.73 1.29 0.964-1.73 0.957 0.639-1.43 0.833 1.24 0.848-1.82 0.266 1.34 0.918-1.95 0.131 TRUE FALSE FALSE TRUE Both 233 2330 GRCh37/hg19 P<=3.16e-09 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000623/ScoringFiles/ phewas/PRSWEB_PHECODE191.11_GWAS-Catalog-r2019-05-03-X191.11_PT_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE191.11_GWAS-Catalog-r2019-05-03-X191.11_PT_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode191-11-ukbb-saige-hrc-x191-11-pt-mgi-20200608 prsweb-phecode191-11-ukbb-saige-hrc-x191-11-pt-mgi-20200608 PRSWEB_PHECODE191.11_UKBB-SAIGE-HRC-X191.11_PT_MGI_20200608 P&T PRSWEB_PHECODE191.11_UKBB-SAIGE-HRC-X191.11_PT_MGI_20200608 191.11 Cancer of brain Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative P&T UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 11 0.043 0.00566359 0.0825 0.53 0.492-0.57 OR 2.28 0.88-5.88 2.28 0.88-5.88 1.81 0.855-3.81 1.81 0.855-3.81 1.34 0.773-2.31 1.34 0.773-2.31 1.05 0.676-1.63 1.05 0.676-1.63 1.3 0.966-1.74 1.3 0.966-1.74 0.91 0.604-1.37 0.651 1.27 0.87-1.86 0.215 1.37 0.944-2 0.0971 TRUE FALSE FALSE TRUE Both 233 2330 GRCh37/hg19 P<=2.51e-06 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000625/ScoringFiles/ phewas/PRSWEB_PHECODE191.11_UKBB-SAIGE-HRC-X191.11_PT_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE191.11_UKBB-SAIGE-HRC-X191.11_PT_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode191-11-c3-brain-prs-cs-mgi-20200608 prsweb-phecode191-11-c3-brain-prs-cs-mgi-20200608 PRSWEB_PHECODE191.11_C3-BRAIN_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE191.11_C3-BRAIN_PRS-CS_MGI_20200608 191.11 Malignant neoplasm of brain Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative PRS-CS UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1050964 0.39 0.000407059 0.0826 0.508 0.471-0.549 OR 1.43 0.454-4.49 1.43 0.454-4.49 1.59 0.724-3.5 1.59 0.724-3.5 1.43 0.838-2.44 1.43 0.838-2.44 1.35 0.9-2.02 1.35 0.9-2.02 0.954 0.698-1.3 0.954 0.698-1.3 0.882 0.601-1.29 0.521 1.06 0.734-1.53 0.76 0.936 0.642-1.37 0.732 FALSE FALSE FALSE FALSE Both 233 2330 GRCh37/hg19 auto 2020-06-08 prsweb-phecode191-11-c71-prs-cs-mgi-20200608 prsweb-phecode191-11-c71-prs-cs-mgi-20200608 PRSWEB_PHECODE191.11_C71_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE191.11_C71_PRS-CS_MGI_20200608 191.11 Diagnoses - main ICD10: C71 Malignant neoplasm of brain Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative PRS-CS UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1055124 0.49 0.00021369 0.0826 0.514 0.476-0.556 OR 0.607 0.113-3.25 0.607 0.113-3.25 1.16 0.473-2.85 1.16 0.473-2.85 0.981 0.527-1.83 0.981 0.527-1.83 1.05 0.68-1.64 1.05 0.68-1.64 1.02 0.751-1.39 1.02 0.751-1.39 1.34 0.911-1.98 0.137 1.21 0.823-1.79 0.329 1.17 0.791-1.74 0.43 FALSE FALSE FALSE FALSE Both 233 2330 GRCh37/hg19 auto 2020-06-08 prsweb-phecode191-11-ukbb-saige-hrc-x191-11-prs-cs-mgi-20200608 prsweb-phecode191-11-ukbb-saige-hrc-x191-11-prs-cs-mgi-20200608 PRSWEB_PHECODE191.11_UKBB-SAIGE-HRC-X191.11_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE191.11_UKBB-SAIGE-HRC-X191.11_PRS-CS_MGI_20200608 191.11 Cancer of brain Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative PRS-CS UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1119238 0.11 0.000581856 0.0825 0.527 0.487-0.567 OR 1.04 0.274-3.91 1.04 0.274-3.91 1.39 0.603-3.21 1.39 0.603-3.21 1.25 0.71-2.19 1.25 0.71-2.19 1.15 0.749-1.75 1.15 0.749-1.75 1.15 0.848-1.55 1.15 0.848-1.55 1.52 1.02-2.26 0.0387 1.38 0.924-2.07 0.115 1.5 1.01-2.24 0.0458 FALSE FALSE FALSE FALSE Both 233 2330 GRCh37/hg19 auto 2020-06-08 prsweb-phecode191-11-20001-1032-lassosum-mgi-20200608 prsweb-phecode191-11-20001-1032-lassosum-mgi-20200608 PRSWEB_PHECODE191.11_20001-1032_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE191.11_20001-1032_LASSOSUM_MGI_20200608 191.11 Cancer code, self-reported: brain cancer / primary malignant brain tumour Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative lassosum UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 24094 0.6 0.00233931 0.0826 0.509 0.474-0.55 OR 3.13 1.35-7.28 3.13 1.35-7.28 1.83 0.865-3.86 1.83 0.865-3.86 1.07 0.585-1.94 1.07 0.585-1.94 1.1 0.716-1.7 1.1 0.716-1.7 1.05 0.771-1.43 1.05 0.771-1.43 0.719 0.486-1.06 0.0993 1.01 0.699-1.45 0.972 0.912 0.629-1.32 0.627 FALSE FALSE FALSE FALSE Both 233 2330 GRCh37/hg19 s=0.2;Lambda=0.07848 2020-06-08 prsweb-phecode191-11-c3-brain-lassosum-mgi-20200608 prsweb-phecode191-11-c3-brain-lassosum-mgi-20200608 PRSWEB_PHECODE191.11_C3-BRAIN_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE191.11_C3-BRAIN_LASSOSUM_MGI_20200608 191.11 Malignant neoplasm of brain Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative lassosum UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 3656328 0.49 0.000529995 0.0826 0.51 0.473-0.545 OR 1.84 0.658-5.17 1.84 0.658-5.17 1.15 0.469-2.83 1.15 0.469-2.83 0.883 0.463-1.69 0.883 0.463-1.69 0.863 0.538-1.38 0.863 0.538-1.38 0.845 0.612-1.17 0.845 0.612-1.17 1.32 0.887-1.95 0.173 1.6 1.09-2.34 0.0158 1.12 0.744-1.69 0.584 FALSE FALSE FALSE FALSE Both 233 2330 GRCh37/hg19 s=0.9;Lambda=0.002069 2020-06-08 prsweb-phecode191-11-c71-lassosum-mgi-20200608 prsweb-phecode191-11-c71-lassosum-mgi-20200608 PRSWEB_PHECODE191.11_C71_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE191.11_C71_LASSOSUM_MGI_20200608 191.11 Diagnoses - main ICD10: C71 Malignant neoplasm of brain Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative lassosum UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 522 0.0092 0.00158244 0.0824 0.546 0.504-0.587 OR 1.42 0.453-4.47 1.42 0.453-4.47 1.37 0.595-3.17 1.37 0.595-3.17 1.07 0.587-1.95 1.07 0.587-1.95 1.56 1.06-2.29 1.56 1.06-2.29 1.46 1.09-1.94 1.46 1.09-1.94 1.23 0.824-1.83 0.313 1.18 0.79-1.77 0.414 1.65 1.13-2.41 0.0102 TRUE FALSE FALSE TRUE Both 233 2330 GRCh37/hg19 s=0.9;Lambda=0.1 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000620/ScoringFiles/ phewas/PRSWEB_PHECODE191.11_C71_LASSOSUM_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE191.11_C71_LASSOSUM_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode191-11-ukbb-saige-hrc-x191-11-lassosum-mgi-20200608 prsweb-phecode191-11-ukbb-saige-hrc-x191-11-lassosum-mgi-20200608 PRSWEB_PHECODE191.11_UKBB-SAIGE-HRC-X191.11_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE191.11_UKBB-SAIGE-HRC-X191.11_LASSOSUM_MGI_20200608 191.11 Cancer of brain Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative lassosum UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1621 0.12 0.00312641 0.0826 0.538 0.501-0.576 OR 1.01 0.268-3.82 1.01 0.268-3.82 0.516 0.143-1.87 0.516 0.143-1.87 0.799 0.407-1.57 0.799 0.407-1.57 0.911 0.573-1.45 0.911 0.573-1.45 1.3 0.966-1.74 1.3 0.966-1.74 1.35 0.907-2.01 0.138 1.29 0.861-1.93 0.217 1.55 1.05-2.3 0.0281 FALSE FALSE FALSE FALSE Both 233 2330 GRCh37/hg19 s=0.5;Lambda=0.07848 2020-06-08 prsweb-phecode191-11-gwas-catalog-r2019-05-03-x191-11-p-5e-05-ukb-20200608 prsweb-phecode191-11-gwas-catalog-r2019-05-03-x191-11-p-5e-05-ukb-20200608 PRSWEB_PHECODE191.11_GWAS-Catalog-r2019-05-03-X191.11_P_5e-05_UKB_20200608 P_5e-05 PRSWEB_PHECODE191.11_GWAS-Catalog-r2019-05-03-X191.11_P_5e-05_UKB_20200608 191.11 Glioblastoma Binary 15 unique SNPs UKB UK Biobank Fixed threshold (5e-05) GWAS Catalog (2019-05-03) 22472174;26424050;28346443 https://www.ncbi.nlm.nih.gov/pubmed/?term=22472174+26424050+28346443 15 2.3e-12 0.0465402 0.0812 0.618 0.582-0.652 OR 3.76 1.82-7.79 3.76 1.82-7.79 3.27 1.88-5.7 3.27 1.88-5.7 2.17 1.42-3.31 2.17 1.42-3.31 2.68 1.97-3.64 2.68 1.97-3.64 2.42 1.88-3.11 2.42 1.88-3.11 1.12 0.744-1.68 0.593 1.18 0.792-1.77 0.412 2.64 1.86-3.75 6.39e-08 TRUE FALSE FALSE FALSE Both 275 2745 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode191-11-gwas-catalog-r2019-05-03-x191-11-p-5e-06-ukb-20200608 prsweb-phecode191-11-gwas-catalog-r2019-05-03-x191-11-p-5e-06-ukb-20200608 PRSWEB_PHECODE191.11_GWAS-Catalog-r2019-05-03-X191.11_P_5e-06_UKB_20200608 P_5e-06 PRSWEB_PHECODE191.11_GWAS-Catalog-r2019-05-03-X191.11_P_5e-06_UKB_20200608 191.11 Glioblastoma Binary 15 unique SNPs UKB UK Biobank Fixed threshold (5e-06) GWAS Catalog (2019-05-03) 22472174;26424050;28346443 https://www.ncbi.nlm.nih.gov/pubmed/?term=22472174+26424050+28346443 14 7.1e-12 0.0442931 0.0813 0.616 0.581-0.649 OR 3.03 1.38-6.65 3.03 1.38-6.65 3.07 1.74-5.42 3.07 1.74-5.42 2 1.29-3.09 2 1.29-3.09 2.47 1.8-3.37 2.47 1.8-3.37 2.35 1.83-3.03 2.35 1.83-3.03 1.3 0.862-1.96 0.211 1.36 0.909-2.05 0.133 2.81 1.96-4.04 2.29e-08 TRUE FALSE FALSE FALSE Both 275 2745 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode191-11-gwas-catalog-r2019-05-03-x191-11-p-5e-07-ukb-20200608 prsweb-phecode191-11-gwas-catalog-r2019-05-03-x191-11-p-5e-07-ukb-20200608 PRSWEB_PHECODE191.11_GWAS-Catalog-r2019-05-03-X191.11_P_5e-07_UKB_20200608 P_5e-07 PRSWEB_PHECODE191.11_GWAS-Catalog-r2019-05-03-X191.11_P_5e-07_UKB_20200608 191.11 Glioblastoma Binary 15 unique SNPs UKB UK Biobank Fixed threshold (5e-07) GWAS Catalog (2019-05-03) 22472174;26424050;28346443 https://www.ncbi.nlm.nih.gov/pubmed/?term=22472174+26424050+28346443 12 2.2e-10 0.0500178 0.0815 0.605 0.569-0.639 OR 3.38 1.59-7.2 3.38 1.59-7.2 3.28 1.88-5.72 3.28 1.88-5.72 2.6 1.74-3.88 2.6 1.74-3.88 2.06 1.48-2.85 2.06 1.48-2.85 2.22 1.72-2.86 2.22 1.72-2.86 1.51 1-2.28 0.0484 1.51 1-2.28 0.0491 2.96 2.04-4.31 1.18e-08 TRUE FALSE FALSE FALSE Both 275 2745 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode191-11-gwas-catalog-r2019-05-03-x191-11-p-5e-09-ukb-20200608 prsweb-phecode191-11-gwas-catalog-r2019-05-03-x191-11-p-5e-09-ukb-20200608 PRSWEB_PHECODE191.11_GWAS-Catalog-r2019-05-03-X191.11_P_5e-09_UKB_20200608 P_5e-09 PRSWEB_PHECODE191.11_GWAS-Catalog-r2019-05-03-X191.11_P_5e-09_UKB_20200608 191.11 Glioblastoma Binary 15 unique SNPs UKB UK Biobank Fixed threshold (5e-09) GWAS Catalog (2019-05-03) 22472174;26424050;28346443 https://www.ncbi.nlm.nih.gov/pubmed/?term=22472174+26424050+28346443 11 2.4e-10 0.0480838 0.0815 0.605 0.57-0.639 OR 3.02 1.37-6.64 3.02 1.37-6.64 3.28 1.88-5.72 3.28 1.88-5.72 2.51 1.67-3.76 2.51 1.67-3.76 1.91 1.37-2.67 1.91 1.37-2.67 2.06 1.6-2.65 2.06 1.6-2.65 1.55 1.03-2.34 0.0363 1.62 1.08-2.42 0.0205 2.84 1.95-4.14 4.78e-08 TRUE FALSE FALSE FALSE Both 275 2745 GRCh37/hg19 P<=5e-09 2020-06-08 prsweb-phecode191-11-gwas-catalog-r2019-05-03-x191-11-p-5e-08-ukb-20200608 prsweb-phecode191-11-gwas-catalog-r2019-05-03-x191-11-p-5e-08-ukb-20200608 PRSWEB_PHECODE191.11_GWAS-Catalog-r2019-05-03-X191.11_P_5e-08_UKB_20200608 P_5e-08 PRSWEB_PHECODE191.11_GWAS-Catalog-r2019-05-03-X191.11_P_5e-08_UKB_20200608 191.11 Glioblastoma Binary 15 unique SNPs UKB UK Biobank GWAS Hits GWAS Catalog (2019-05-03) 22472174;26424050;28346443 https://www.ncbi.nlm.nih.gov/pubmed/?term=22472174+26424050+28346443 12 2.2e-10 0.0500178 0.0815 0.605 0.569-0.639 OR 3.38 1.59-7.2 3.38 1.59-7.2 3.28 1.88-5.72 3.28 1.88-5.72 2.6 1.74-3.88 2.6 1.74-3.88 2.06 1.48-2.85 2.06 1.48-2.85 2.22 1.72-2.86 2.22 1.72-2.86 1.51 1-2.28 0.0484 1.51 1-2.28 0.0491 2.96 2.04-4.31 1.18e-08 TRUE FALSE FALSE TRUE Both 275 2745 GRCh37/hg19 P<=5e-08 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000622/ScoringFiles/ phewas/PRSWEB_PHECODE191.11_GWAS-Catalog-r2019-05-03-X191.11_P_5e-08_UKB_20200608/all.tsv phewas/PRSWEB_PHECODE191.11_GWAS-Catalog-r2019-05-03-X191.11_P_5e-08_UKB_20200608/exclusion.tsv 2020-06-08 prsweb-phecode191-11-gwas-catalog-r2019-05-03-x191-11-pt-ukb-20200608 prsweb-phecode191-11-gwas-catalog-r2019-05-03-x191-11-pt-ukb-20200608 PRSWEB_PHECODE191.11_GWAS-Catalog-r2019-05-03-X191.11_PT_UKB_20200608 P&T PRSWEB_PHECODE191.11_GWAS-Catalog-r2019-05-03-X191.11_PT_UKB_20200608 191.11 Glioblastoma Binary 15 unique SNPs UKB UK Biobank P&T GWAS Catalog (2019-05-03) 22472174;26424050;28346443 https://www.ncbi.nlm.nih.gov/pubmed/?term=22472174+26424050+28346443 5 1.1e-11 0.0529333 0.0813 0.606 0.568-0.642 OR 4.15 2.04-8.41 4.15 2.04-8.41 3.56 2.11-5.99 3.56 2.11-5.99 2.44 1.68-3.55 2.44 1.68-3.55 2.11 1.55-2.89 2.11 1.55-2.89 2.01 1.56-2.59 2.01 1.56-2.59 1.4 0.931-2.1 0.106 1.96 1.32-2.91 0.000806 3.1 2.09-4.59 1.54e-08 TRUE FALSE FALSE TRUE Both 275 2745 GRCh37/hg19 P<=5.01e-29 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000624/ScoringFiles/ phewas/PRSWEB_PHECODE191.11_GWAS-Catalog-r2019-05-03-X191.11_PT_UKB_20200608/all.tsv phewas/PRSWEB_PHECODE191.11_GWAS-Catalog-r2019-05-03-X191.11_PT_UKB_20200608/exclusion.tsv 2020-06-08 prsweb-phecode193-20001-1065-p-5e-05-mgi-20200608 prsweb-phecode193-20001-1065-p-5e-05-mgi-20200608 PRSWEB_PHECODE193_20001-1065_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE193_20001-1065_P_5e-05_MGI_20200608 193 Cancer code, self-reported: thyroid cancer Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 69 0.0068 0.0019543 0.0827 0.534 0.505-0.565 OR 1.13 0.42-3.04 1.13 0.42-3.04 0.948 0.444-2.02 0.948 0.444-2.02 1.31 0.858-2.02 1.31 0.858-2.02 1.33 0.972-1.82 1.33 0.972-1.82 1.21 0.962-1.53 1.21 0.962-1.53 1.02 0.752-1.4 0.878 1.22 0.907-1.65 0.187 1.32 0.981-1.77 0.0674 TRUE FALSE FALSE FALSE Both 389 3881 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode193-c3-thyroid-gland-p-5e-05-mgi-20200608 prsweb-phecode193-c3-thyroid-gland-p-5e-05-mgi-20200608 PRSWEB_PHECODE193_C3-THYROID-GLAND_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE193_C3-THYROID-GLAND_P_5e-05_MGI_20200608 193 Malignant neoplasm of thyroid gland Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 96 0.016 0.00422867 0.0827 0.532 0.503-0.561 OR 1.65 0.708-3.83 1.65 0.708-3.83 1.34 0.696-2.58 1.34 0.696-2.58 1.49 0.988-2.23 1.49 0.988-2.23 1.46 1.07-1.98 1.46 1.07-1.98 1.17 0.928-1.48 1.17 0.928-1.48 1.1 0.808-1.5 0.538 1.35 0.998-1.81 0.0517 1.35 0.997-1.82 0.0526 TRUE FALSE FALSE FALSE Both 389 3881 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode193-c73-p-5e-05-mgi-20200608 prsweb-phecode193-c73-p-5e-05-mgi-20200608 PRSWEB_PHECODE193_C73_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE193_C73_P_5e-05_MGI_20200608 193 Diagnoses - main ICD10: C73 Malignant neoplasm of thyroid gland Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 76 0.054 0.00674073 0.0827 0.527 0.494-0.558 OR 1.13 0.42-3.04 1.13 0.42-3.04 1.34 0.694-2.57 1.34 0.694-2.57 1.26 0.817-1.95 1.26 0.817-1.95 1.64 1.23-2.2 1.64 1.23-2.2 1.4 1.12-1.76 1.4 1.12-1.76 0.937 0.692-1.27 0.671 0.879 0.647-1.19 0.408 1.3 0.984-1.73 0.0642 FALSE FALSE FALSE FALSE Both 389 3881 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode193-gwas-catalog-r2019-05-03-x193-p-5e-05-mgi-20200608 prsweb-phecode193-gwas-catalog-r2019-05-03-x193-p-5e-05-mgi-20200608 PRSWEB_PHECODE193_GWAS-Catalog-r2019-05-03-X193_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE193_GWAS-Catalog-r2019-05-03-X193_P_5e-05_MGI_20200608 193 Thyroid cancer Binary 19 unique SNPs MGI Michigan Genomics Initiative Fixed threshold (5e-05) GWAS Catalog (2019-05-03) 19198613;22267200;23894154;25855579;28195142 https://www.ncbi.nlm.nih.gov/pubmed/?term=19198613+22267200+23894154+25855579+28195142 11 2.3e-19 0.0387304 0.0811 0.63 0.601-0.658 OR 3.26 1.69-6.26 3.26 1.69-6.26 3.12 1.94-5.02 3.12 1.94-5.02 2.68 1.92-3.74 2.68 1.92-3.74 2.63 2.03-3.41 2.63 2.03-3.41 2.33 1.88-2.88 2.33 1.88-2.88 1.45 1.01-2.1 0.0448 1.9 1.34-2.69 0.000338 3.41 2.46-4.72 1.55e-13 TRUE FALSE FALSE FALSE Both 389 3881 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode193-ukbb-saige-hrc-x193-p-5e-05-mgi-20200608 prsweb-phecode193-ukbb-saige-hrc-x193-p-5e-05-mgi-20200608 PRSWEB_PHECODE193_UKBB-SAIGE-HRC-X193_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE193_UKBB-SAIGE-HRC-X193_P_5e-05_MGI_20200608 193 Thyroid cancer Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 86 0.0076 0.00253866 0.0827 0.529 0.498-0.558 OR 1.92 0.865-4.24 1.92 0.865-4.24 1.6 0.873-2.94 1.6 0.873-2.94 1.72 1.16-2.53 1.72 1.16-2.53 1.49 1.1-2.01 1.49 1.1-2.01 1.21 0.963-1.53 1.21 0.963-1.53 1.25 0.916-1.7 0.16 1.29 0.951-1.76 0.101 1.41 1.04-1.9 0.0269 TRUE FALSE FALSE FALSE Both 389 3881 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode193-20001-1065-p-5e-06-mgi-20200608 prsweb-phecode193-20001-1065-p-5e-06-mgi-20200608 PRSWEB_PHECODE193_20001-1065_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE193_20001-1065_P_5e-06_MGI_20200608 193 Cancer code, self-reported: thyroid cancer Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 8 0.0041 0.00738545 0.0826 0.529 0.496-0.559 OR 2.44 1.18-5.02 2.44 1.18-5.02 1.74 0.964-3.13 1.74 0.964-3.13 1.71 1.16-2.52 1.71 1.16-2.52 1.49 1.1-2.01 1.49 1.1-2.01 1.32 1.05-1.66 1.32 1.05-1.66 1.1 0.801-1.5 0.566 1.28 0.943-1.73 0.114 1.48 1.1-1.99 0.00902 TRUE FALSE FALSE FALSE Both 389 3881 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode193-c3-thyroid-gland-p-5e-06-mgi-20200608 prsweb-phecode193-c3-thyroid-gland-p-5e-06-mgi-20200608 PRSWEB_PHECODE193_C3-THYROID-GLAND_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE193_C3-THYROID-GLAND_P_5e-06_MGI_20200608 193 Malignant neoplasm of thyroid gland Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 11 3.4e-06 0.0171123 0.0824 0.56 0.53-0.59 OR 2.42 1.17-4.98 2.42 1.17-4.98 1.73 0.96-3.12 1.73 0.96-3.12 1.48 0.987-2.23 1.48 0.987-2.23 1.58 1.18-2.13 1.58 1.18-2.13 1.39 1.11-1.74 1.39 1.11-1.74 1.33 0.959-1.85 0.0873 1.69 1.23-2.31 0.00107 1.85 1.36-2.52 9.79e-05 TRUE FALSE FALSE FALSE Both 389 3881 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode193-c73-p-5e-06-mgi-20200608 prsweb-phecode193-c73-p-5e-06-mgi-20200608 PRSWEB_PHECODE193_C73_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE193_C73_P_5e-06_MGI_20200608 193 Diagnoses - main ICD10: C73 Malignant neoplasm of thyroid gland Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 15 0.093 0.00796019 0.0827 0.514 0.483-0.546 OR 2.42 1.17-4.98 2.42 1.17-4.98 1.73 0.957-3.12 1.73 0.957-3.12 1.42 0.94-2.16 1.42 0.94-2.16 1.21 0.875-1.67 1.21 0.875-1.67 1.24 0.988-1.56 1.24 0.988-1.56 1.15 0.851-1.55 0.368 1.01 0.741-1.37 0.964 1.31 0.981-1.76 0.0666 FALSE FALSE FALSE FALSE Both 389 3881 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode193-gwas-catalog-r2019-05-03-x193-p-5e-06-mgi-20200608 prsweb-phecode193-gwas-catalog-r2019-05-03-x193-p-5e-06-mgi-20200608 PRSWEB_PHECODE193_GWAS-Catalog-r2019-05-03-X193_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE193_GWAS-Catalog-r2019-05-03-X193_P_5e-06_MGI_20200608 193 Thyroid cancer Binary 19 unique SNPs MGI Michigan Genomics Initiative Fixed threshold (5e-06) GWAS Catalog (2019-05-03) 19198613;22267200;23894154;25855579;28195142 https://www.ncbi.nlm.nih.gov/pubmed/?term=19198613+22267200+23894154+25855579+28195142 11 2.3e-19 0.0387304 0.0811 0.63 0.601-0.658 OR 3.26 1.69-6.26 3.26 1.69-6.26 3.12 1.94-5.02 3.12 1.94-5.02 2.68 1.92-3.74 2.68 1.92-3.74 2.63 2.03-3.41 2.63 2.03-3.41 2.33 1.88-2.88 2.33 1.88-2.88 1.45 1.01-2.1 0.0448 1.9 1.34-2.69 0.000338 3.41 2.46-4.72 1.55e-13 TRUE FALSE FALSE FALSE Both 389 3881 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode193-ukbb-saige-hrc-x193-p-5e-06-mgi-20200608 prsweb-phecode193-ukbb-saige-hrc-x193-p-5e-06-mgi-20200608 PRSWEB_PHECODE193_UKBB-SAIGE-HRC-X193_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE193_UKBB-SAIGE-HRC-X193_P_5e-06_MGI_20200608 193 Thyroid cancer Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 11 0.00033 0.00733806 0.0825 0.54 0.509-0.568 OR 1.89 0.854-4.19 1.89 0.854-4.19 2 1.14-3.49 2 1.14-3.49 1.59 1.07-2.37 1.59 1.07-2.37 1.33 0.974-1.82 1.33 0.974-1.82 1.34 1.07-1.68 1.34 1.07-1.68 1.34 0.971-1.85 0.0746 1.57 1.15-2.14 0.0048 1.73 1.27-2.35 0.000479 TRUE FALSE FALSE FALSE Both 389 3881 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode193-c3-thyroid-gland-p-5e-07-mgi-20200608 prsweb-phecode193-c3-thyroid-gland-p-5e-07-mgi-20200608 PRSWEB_PHECODE193_C3-THYROID-GLAND_P_5e-07_MGI_20200608 P_5e-07 PRSWEB_PHECODE193_C3-THYROID-GLAND_P_5e-07_MGI_20200608 193 Malignant neoplasm of thyroid gland Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-07) UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 5 6.1e-05 0.00966258 0.0825 0.549 0.518-0.58 OR 1.39 0.562-3.44 1.39 0.562-3.44 1.34 0.695-2.58 1.34 0.695-2.58 1.54 1.03-2.3 1.54 1.03-2.3 1.65 1.23-2.21 1.65 1.23-2.21 1.47 1.18-1.84 1.47 1.18-1.84 1.05 0.753-1.46 0.777 1.56 1.15-2.12 0.00459 1.76 1.31-2.38 0.000214 TRUE FALSE FALSE FALSE Both 389 3881 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode193-gwas-catalog-r2019-05-03-x193-p-5e-07-mgi-20200608 prsweb-phecode193-gwas-catalog-r2019-05-03-x193-p-5e-07-mgi-20200608 PRSWEB_PHECODE193_GWAS-Catalog-r2019-05-03-X193_P_5e-07_MGI_20200608 P_5e-07 PRSWEB_PHECODE193_GWAS-Catalog-r2019-05-03-X193_P_5e-07_MGI_20200608 193 Thyroid cancer Binary 19 unique SNPs MGI Michigan Genomics Initiative Fixed threshold (5e-07) GWAS Catalog (2019-05-03) 19198613;22267200;23894154;25855579;28195142 https://www.ncbi.nlm.nih.gov/pubmed/?term=19198613+22267200+23894154+25855579+28195142 11 2.3e-19 0.0387304 0.0811 0.63 0.601-0.658 OR 3.26 1.69-6.26 3.26 1.69-6.26 3.12 1.94-5.02 3.12 1.94-5.02 2.68 1.92-3.74 2.68 1.92-3.74 2.63 2.03-3.41 2.63 2.03-3.41 2.33 1.88-2.88 2.33 1.88-2.88 1.45 1.01-2.1 0.0448 1.9 1.34-2.69 0.000338 3.41 2.46-4.72 1.55e-13 TRUE FALSE FALSE FALSE Both 389 3881 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode193-gwas-catalog-r2019-05-03-x193-p-5e-09-mgi-20200608 prsweb-phecode193-gwas-catalog-r2019-05-03-x193-p-5e-09-mgi-20200608 PRSWEB_PHECODE193_GWAS-Catalog-r2019-05-03-X193_P_5e-09_MGI_20200608 P_5e-09 PRSWEB_PHECODE193_GWAS-Catalog-r2019-05-03-X193_P_5e-09_MGI_20200608 193 Thyroid cancer Binary 19 unique SNPs MGI Michigan Genomics Initiative Fixed threshold (5e-09) GWAS Catalog (2019-05-03) 19198613;22267200;23894154;25855579;28195142 https://www.ncbi.nlm.nih.gov/pubmed/?term=19198613+22267200+23894154+25855579+28195142 9 1.4e-17 0.0386535 0.0812 0.62 0.591-0.649 OR 4.04 2.21-7.39 4.04 2.21-7.39 3.83 2.46-5.98 3.83 2.46-5.98 2.74 1.97-3.82 2.74 1.97-3.82 2.48 1.91-3.22 2.48 1.91-3.22 2.1 1.69-2.6 2.1 1.69-2.6 1.35 0.94-1.93 0.105 1.87 1.33-2.62 0.000297 2.94 2.14-4.05 3.12e-11 TRUE FALSE FALSE FALSE Both 389 3881 GRCh37/hg19 P<=5e-09 2020-06-08 prsweb-phecode193-gwas-catalog-r2019-05-03-x193-p-5e-08-mgi-20200608 prsweb-phecode193-gwas-catalog-r2019-05-03-x193-p-5e-08-mgi-20200608 PRSWEB_PHECODE193_GWAS-Catalog-r2019-05-03-X193_P_5e-08_MGI_20200608 P_5e-08 PRSWEB_PHECODE193_GWAS-Catalog-r2019-05-03-X193_P_5e-08_MGI_20200608 193 Thyroid cancer Binary 19 unique SNPs MGI Michigan Genomics Initiative GWAS Hits GWAS Catalog (2019-05-03) 19198613;22267200;23894154;25855579;28195142 https://www.ncbi.nlm.nih.gov/pubmed/?term=19198613+22267200+23894154+25855579+28195142 10 2e-18 0.0374073 0.0811 0.626 0.597-0.655 OR 3.53 1.87-6.66 3.53 1.87-6.66 2.7 1.64-4.46 2.7 1.64-4.46 2.81 2.02-3.9 2.81 2.02-3.9 2.48 1.91-3.22 2.48 1.91-3.22 2.24 1.81-2.77 2.24 1.81-2.77 1.46 1.02-2.11 0.0412 1.96 1.39-2.78 0.000142 3.34 2.41-4.63 4.81e-13 TRUE FALSE FALSE TRUE Both 389 3881 GRCh37/hg19 P<=5e-08 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000630/ScoringFiles/ phewas/PRSWEB_PHECODE193_GWAS-Catalog-r2019-05-03-X193_P_5e-08_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE193_GWAS-Catalog-r2019-05-03-X193_P_5e-08_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode193-20001-1065-pt-mgi-20200608 prsweb-phecode193-20001-1065-pt-mgi-20200608 PRSWEB_PHECODE193_20001-1065_PT_MGI_20200608 P&T PRSWEB_PHECODE193_20001-1065_PT_MGI_20200608 193 Cancer code, self-reported: thyroid cancer Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative P&T UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 8 0.0041 0.00738545 0.0826 0.529 0.496-0.559 OR 2.44 1.18-5.02 2.44 1.18-5.02 1.74 0.964-3.13 1.74 0.964-3.13 1.71 1.16-2.52 1.71 1.16-2.52 1.49 1.1-2.01 1.49 1.1-2.01 1.32 1.05-1.66 1.32 1.05-1.66 1.1 0.801-1.5 0.566 1.28 0.943-1.73 0.114 1.48 1.1-1.99 0.00902 TRUE FALSE FALSE TRUE Both 389 3881 GRCh37/hg19 P<=3.98e-06 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000626/ScoringFiles/ phewas/PRSWEB_PHECODE193_20001-1065_PT_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE193_20001-1065_PT_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode193-c3-thyroid-gland-pt-mgi-20200608 prsweb-phecode193-c3-thyroid-gland-pt-mgi-20200608 PRSWEB_PHECODE193_C3-THYROID-GLAND_PT_MGI_20200608 P&T PRSWEB_PHECODE193_C3-THYROID-GLAND_PT_MGI_20200608 193 Malignant neoplasm of thyroid gland Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative P&T UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 11 3.4e-06 0.0171123 0.0824 0.56 0.53-0.59 OR 2.42 1.17-4.98 2.42 1.17-4.98 1.73 0.96-3.12 1.73 0.96-3.12 1.48 0.987-2.23 1.48 0.987-2.23 1.58 1.18-2.13 1.58 1.18-2.13 1.39 1.11-1.74 1.39 1.11-1.74 1.33 0.959-1.85 0.0873 1.69 1.23-2.31 0.00107 1.85 1.36-2.52 9.79e-05 TRUE FALSE FALSE TRUE Both 389 3881 GRCh37/hg19 P<=5e-06 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000627/ScoringFiles/ phewas/PRSWEB_PHECODE193_C3-THYROID-GLAND_PT_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE193_C3-THYROID-GLAND_PT_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode193-c73-pt-mgi-20200608 prsweb-phecode193-c73-pt-mgi-20200608 PRSWEB_PHECODE193_C73_PT_MGI_20200608 P&T PRSWEB_PHECODE193_C73_PT_MGI_20200608 193 Diagnoses - main ICD10: C73 Malignant neoplasm of thyroid gland Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative P&T UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 8 0.027 0.00999042 0.0827 0.52 0.488-0.55 OR 2.15 1.01-4.59 2.15 1.01-4.59 1.73 0.956-3.12 1.73 0.956-3.12 1.77 1.2-2.59 1.77 1.2-2.59 1.49 1.1-2.01 1.49 1.1-2.01 1.18 0.938-1.49 1.18 0.938-1.49 1.05 0.77-1.42 0.769 1.22 0.906-1.64 0.189 1.29 0.961-1.74 0.0902 TRUE FALSE FALSE TRUE Both 389 3881 GRCh37/hg19 P<=1.26e-06 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000629/ScoringFiles/ phewas/PRSWEB_PHECODE193_C73_PT_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE193_C73_PT_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode193-gwas-catalog-r2019-05-03-x193-pt-mgi-20200608 prsweb-phecode193-gwas-catalog-r2019-05-03-x193-pt-mgi-20200608 PRSWEB_PHECODE193_GWAS-Catalog-r2019-05-03-X193_PT_MGI_20200608 P&T PRSWEB_PHECODE193_GWAS-Catalog-r2019-05-03-X193_PT_MGI_20200608 193 Thyroid cancer Binary 19 unique SNPs MGI Michigan Genomics Initiative P&T GWAS Catalog (2019-05-03) 19198613;22267200;23894154;25855579;28195142 https://www.ncbi.nlm.nih.gov/pubmed/?term=19198613+22267200+23894154+25855579+28195142 8 2.9e-17 0.0417495 0.0812 0.618 0.587-0.647 OR 5.14 2.94-8.99 5.14 2.94-8.99 3.54 2.25-5.59 3.54 2.25-5.59 3.06 2.22-4.22 3.06 2.22-4.22 2.44 1.87-3.17 2.44 1.87-3.17 2.07 1.67-2.57 2.07 1.67-2.57 1.37 0.956-1.96 0.0869 1.89 1.34-2.64 0.000241 2.9 2.1-3.98 6.48e-11 TRUE FALSE FALSE TRUE Both 389 3881 GRCh37/hg19 P<=3.16e-10 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000632/ScoringFiles/ phewas/PRSWEB_PHECODE193_GWAS-Catalog-r2019-05-03-X193_PT_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE193_GWAS-Catalog-r2019-05-03-X193_PT_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode193-ukbb-saige-hrc-x193-pt-mgi-20200608 prsweb-phecode193-ukbb-saige-hrc-x193-pt-mgi-20200608 PRSWEB_PHECODE193_UKBB-SAIGE-HRC-X193_PT_MGI_20200608 P&T PRSWEB_PHECODE193_UKBB-SAIGE-HRC-X193_PT_MGI_20200608 193 Thyroid cancer Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative P&T UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 5 2.7e-08 0.0157305 0.0822 0.569 0.538-0.598 OR 1.65 0.708-3.83 1.65 0.708-3.83 1.6 0.871-2.94 1.6 0.871-2.94 1.77 1.21-2.6 1.77 1.21-2.6 1.91 1.44-2.53 1.91 1.44-2.53 1.58 1.26-1.97 1.58 1.26-1.97 1.3 0.924-1.83 0.132 1.69 1.23-2.34 0.00142 2.09 1.53-2.86 4.17e-06 TRUE FALSE FALSE TRUE Both 389 3881 GRCh37/hg19 P<=2e-06 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000635/ScoringFiles/ phewas/PRSWEB_PHECODE193_UKBB-SAIGE-HRC-X193_PT_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE193_UKBB-SAIGE-HRC-X193_PT_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode193-20001-1065-prs-cs-mgi-20200608 prsweb-phecode193-20001-1065-prs-cs-mgi-20200608 PRSWEB_PHECODE193_20001-1065_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE193_20001-1065_PRS-CS_MGI_20200608 193 Cancer code, self-reported: thyroid cancer Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative PRS-CS UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1042118 0.11 0.000177902 0.0827 0.526 0.497-0.558 OR 2.16 1.01-4.6 2.16 1.01-4.6 1.6 0.869-2.93 1.6 0.869-2.93 1.43 0.943-2.16 1.43 0.943-2.16 1.09 0.782-1.53 1.09 0.782-1.53 1.23 0.975-1.54 1.23 0.975-1.54 1.09 0.807-1.47 0.574 1.04 0.769-1.41 0.789 1.29 0.966-1.73 0.0838 FALSE FALSE FALSE FALSE Both 389 3881 GRCh37/hg19 auto 2020-06-08 prsweb-phecode193-c3-thyroid-gland-prs-cs-mgi-20200608 prsweb-phecode193-c3-thyroid-gland-prs-cs-mgi-20200608 PRSWEB_PHECODE193_C3-THYROID-GLAND_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE193_C3-THYROID-GLAND_PRS-CS_MGI_20200608 193 Malignant neoplasm of thyroid gland Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative PRS-CS UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1054932 0.24 0.000454599 0.0828 0.52 0.49-0.549 OR 1.65 0.708-3.83 1.65 0.708-3.83 1.08 0.526-2.21 1.08 0.526-2.21 1.32 0.859-2.02 1.32 0.859-2.02 1.15 0.83-1.6 1.15 0.83-1.6 0.999 0.785-1.27 0.999 0.785-1.27 1.27 0.932-1.72 0.131 1.46 1.08-1.96 0.014 1.24 0.913-1.7 0.166 FALSE FALSE FALSE FALSE Both 389 3881 GRCh37/hg19 auto 2020-06-08 prsweb-phecode193-c73-prs-cs-mgi-20200608 prsweb-phecode193-c73-prs-cs-mgi-20200608 PRSWEB_PHECODE193_C73_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE193_C73_PRS-CS_MGI_20200608 193 Diagnoses - main ICD10: C73 Malignant neoplasm of thyroid gland Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative PRS-CS UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1027375 0.13 0.000138231 0.0828 0.527 0.498-0.558 OR 0.377 0.0725-1.96 0.377 0.0725-1.96 0.695 0.29-1.67 0.695 0.29-1.67 1.48 0.987-2.23 1.48 0.987-2.23 1.42 1.05-1.93 1.42 1.05-1.93 1.21 0.965-1.53 1.21 0.965-1.53 1.31 0.964-1.77 0.0846 1.16 0.851-1.58 0.346 1.41 1.04-1.89 0.0255 FALSE FALSE FALSE FALSE Both 389 3881 GRCh37/hg19 auto 2020-06-08 prsweb-phecode193-ukbb-saige-hrc-x193-prs-cs-mgi-20200608 prsweb-phecode193-ukbb-saige-hrc-x193-prs-cs-mgi-20200608 PRSWEB_PHECODE193_UKBB-SAIGE-HRC-X193_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE193_UKBB-SAIGE-HRC-X193_PRS-CS_MGI_20200608 193 Thyroid cancer Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative PRS-CS UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1119238 0.035 0.000208927 0.0827 0.535 0.504-0.567 OR 1.39 0.562-3.45 1.39 0.562-3.45 1.34 0.696-2.58 1.34 0.696-2.58 1.32 0.86-2.02 1.32 0.86-2.02 1.27 0.926-1.75 1.27 0.926-1.75 1.21 0.964-1.53 1.21 0.964-1.53 1.06 0.779-1.45 0.707 1.24 0.917-1.67 0.163 1.34 0.994-1.79 0.0549 TRUE FALSE FALSE TRUE Both 389 3881 GRCh37/hg19 auto https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000634/ScoringFiles/ phewas/PRSWEB_PHECODE193_UKBB-SAIGE-HRC-X193_PRS-CS_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE193_UKBB-SAIGE-HRC-X193_PRS-CS_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode193-20001-1065-lassosum-mgi-20200608 prsweb-phecode193-20001-1065-lassosum-mgi-20200608 PRSWEB_PHECODE193_20001-1065_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE193_20001-1065_LASSOSUM_MGI_20200608 193 Cancer code, self-reported: thyroid cancer Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative lassosum UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1515 0.14 0.00230821 0.0828 0.518 0.488-0.549 OR 1.39 0.559-3.43 1.39 0.559-3.43 1.6 0.871-2.94 1.6 0.871-2.94 1.04 0.654-1.67 1.04 0.654-1.67 1.01 0.715-1.42 1.01 0.715-1.42 1.2 0.952-1.51 1.2 0.952-1.51 1.19 0.876-1.61 0.268 1.17 0.865-1.59 0.305 1.33 0.985-1.78 0.0629 FALSE FALSE FALSE FALSE Both 389 3881 GRCh37/hg19 s=1;Lambda=0.1 2020-06-08 prsweb-phecode193-c3-thyroid-gland-lassosum-mgi-20200608 prsweb-phecode193-c3-thyroid-gland-lassosum-mgi-20200608 PRSWEB_PHECODE193_C3-THYROID-GLAND_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE193_C3-THYROID-GLAND_LASSOSUM_MGI_20200608 193 Malignant neoplasm of thyroid gland Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative lassosum UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 656 1.7e-06 0.0110299 0.0823 0.565 0.535-0.595 OR 1.91 0.861-4.22 1.91 0.861-4.22 1.74 0.964-3.13 1.74 0.964-3.13 1.6 1.08-2.38 1.6 1.08-2.38 1.62 1.2-2.17 1.62 1.2-2.17 1.42 1.14-1.78 1.42 1.14-1.78 1.22 0.878-1.7 0.236 1.64 1.2-2.24 0.00196 1.83 1.35-2.49 0.00011 TRUE FALSE FALSE TRUE Both 389 3881 GRCh37/hg19 s=1;Lambda=0.1 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000628/ScoringFiles/ phewas/PRSWEB_PHECODE193_C3-THYROID-GLAND_LASSOSUM_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE193_C3-THYROID-GLAND_LASSOSUM_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode193-c73-lassosum-mgi-20200608 prsweb-phecode193-c73-lassosum-mgi-20200608 PRSWEB_PHECODE193_C73_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE193_C73_LASSOSUM_MGI_20200608 193 Diagnoses - main ICD10: C73 Malignant neoplasm of thyroid gland Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative lassosum UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 3017 0.12 0.00378028 0.0828 0.523 0.491-0.556 OR 1.14 0.422-3.05 1.14 0.422-3.05 1.08 0.527-2.21 1.08 0.527-2.21 1.15 0.736-1.81 1.15 0.736-1.81 1.04 0.737-1.46 1.04 0.737-1.46 1.23 0.975-1.54 1.23 0.975-1.54 1.05 0.771-1.42 0.767 1.15 0.85-1.55 0.368 1.33 0.994-1.79 0.0545 FALSE FALSE FALSE FALSE Both 389 3881 GRCh37/hg19 s=0.9;Lambda=0.1 2020-06-08 prsweb-phecode193-ukbb-saige-hrc-x193-lassosum-mgi-20200608 prsweb-phecode193-ukbb-saige-hrc-x193-lassosum-mgi-20200608 PRSWEB_PHECODE193_UKBB-SAIGE-HRC-X193_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE193_UKBB-SAIGE-HRC-X193_LASSOSUM_MGI_20200608 193 Thyroid cancer Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative lassosum UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 954 1.3e-10 0.0135905 0.0819 0.578 0.548-0.607 OR 3.21 1.67-6.15 3.21 1.67-6.15 2.96 1.82-4.79 2.96 1.82-4.79 2.12 1.48-3.04 2.12 1.48-3.04 2.08 1.58-2.74 2.08 1.58-2.74 1.63 1.31-2.03 1.63 1.31-2.03 1.44 1.03-2.02 0.0352 1.75 1.27-2.43 0.000741 2.27 1.66-3.1 3.17e-07 TRUE FALSE FALSE TRUE Both 389 3881 GRCh37/hg19 s=1;Lambda=0.1 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000636/ScoringFiles/ phewas/PRSWEB_PHECODE193_UKBB-SAIGE-HRC-X193_LASSOSUM_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE193_UKBB-SAIGE-HRC-X193_LASSOSUM_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode193-gwas-catalog-r2019-05-03-x193-p-5e-05-ukb-20200608 prsweb-phecode193-gwas-catalog-r2019-05-03-x193-p-5e-05-ukb-20200608 PRSWEB_PHECODE193_GWAS-Catalog-r2019-05-03-X193_P_5e-05_UKB_20200608 P_5e-05 PRSWEB_PHECODE193_GWAS-Catalog-r2019-05-03-X193_P_5e-05_UKB_20200608 193 Thyroid cancer Binary 19 unique SNPs UKB UK Biobank Fixed threshold (5e-05) GWAS Catalog (2019-05-03) 19198613;22267200;23894154;25855579;28195142 https://www.ncbi.nlm.nih.gov/pubmed/?term=19198613+22267200+23894154+25855579+28195142 11 3.1e-10 0.0531724 0.0803 0.639 0.592-0.682 OR 4.41 1.81-10.7 4.41 1.81-10.7 3.64 1.81-7.31 3.64 1.81-7.31 2.74 1.63-4.59 2.74 1.63-4.59 2.33 1.54-3.52 2.33 1.54-3.52 2.42 1.74-3.35 2.42 1.74-3.35 1.6 0.892-2.88 0.115 2.2 1.26-3.84 0.00534 3.95 2.34-6.67 2.62e-07 TRUE FALSE FALSE FALSE Both 161 1617 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode193-gwas-catalog-r2019-05-03-x193-p-5e-06-ukb-20200608 prsweb-phecode193-gwas-catalog-r2019-05-03-x193-p-5e-06-ukb-20200608 PRSWEB_PHECODE193_GWAS-Catalog-r2019-05-03-X193_P_5e-06_UKB_20200608 P_5e-06 PRSWEB_PHECODE193_GWAS-Catalog-r2019-05-03-X193_P_5e-06_UKB_20200608 193 Thyroid cancer Binary 19 unique SNPs UKB UK Biobank Fixed threshold (5e-06) GWAS Catalog (2019-05-03) 19198613;22267200;23894154;25855579;28195142 https://www.ncbi.nlm.nih.gov/pubmed/?term=19198613+22267200+23894154+25855579+28195142 11 3.1e-10 0.0531724 0.0803 0.639 0.592-0.682 OR 4.41 1.81-10.7 4.41 1.81-10.7 3.64 1.81-7.31 3.64 1.81-7.31 2.74 1.63-4.59 2.74 1.63-4.59 2.33 1.54-3.52 2.33 1.54-3.52 2.42 1.74-3.35 2.42 1.74-3.35 1.6 0.892-2.88 0.115 2.2 1.26-3.84 0.00534 3.95 2.34-6.67 2.62e-07 TRUE FALSE FALSE FALSE Both 161 1617 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode193-gwas-catalog-r2019-05-03-x193-p-5e-07-ukb-20200608 prsweb-phecode193-gwas-catalog-r2019-05-03-x193-p-5e-07-ukb-20200608 PRSWEB_PHECODE193_GWAS-Catalog-r2019-05-03-X193_P_5e-07_UKB_20200608 P_5e-07 PRSWEB_PHECODE193_GWAS-Catalog-r2019-05-03-X193_P_5e-07_UKB_20200608 193 Thyroid cancer Binary 19 unique SNPs UKB UK Biobank Fixed threshold (5e-07) GWAS Catalog (2019-05-03) 19198613;22267200;23894154;25855579;28195142 https://www.ncbi.nlm.nih.gov/pubmed/?term=19198613+22267200+23894154+25855579+28195142 11 3.1e-10 0.0531724 0.0803 0.639 0.592-0.682 OR 4.41 1.81-10.7 4.41 1.81-10.7 3.64 1.81-7.31 3.64 1.81-7.31 2.74 1.63-4.59 2.74 1.63-4.59 2.33 1.54-3.52 2.33 1.54-3.52 2.42 1.74-3.35 2.42 1.74-3.35 1.6 0.892-2.88 0.115 2.2 1.26-3.84 0.00534 3.95 2.34-6.67 2.62e-07 TRUE FALSE FALSE FALSE Both 161 1617 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode193-gwas-catalog-r2019-05-03-x193-p-5e-09-ukb-20200608 prsweb-phecode193-gwas-catalog-r2019-05-03-x193-p-5e-09-ukb-20200608 PRSWEB_PHECODE193_GWAS-Catalog-r2019-05-03-X193_P_5e-09_UKB_20200608 P_5e-09 PRSWEB_PHECODE193_GWAS-Catalog-r2019-05-03-X193_P_5e-09_UKB_20200608 193 Thyroid cancer Binary 19 unique SNPs UKB UK Biobank Fixed threshold (5e-09) GWAS Catalog (2019-05-03) 19198613;22267200;23894154;25855579;28195142 https://www.ncbi.nlm.nih.gov/pubmed/?term=19198613+22267200+23894154+25855579+28195142 9 2.6e-10 0.0517251 0.0802 0.634 0.586-0.679 OR 5.04 2.15-11.8 5.04 2.15-11.8 3.6 1.79-7.22 3.6 1.79-7.22 3.7 2.3-5.95 3.7 2.3-5.95 2.98 2.02-4.41 2.98 2.02-4.41 2.24 1.61-3.12 2.24 1.61-3.12 1.22 0.691-2.15 0.497 1.84 1.09-3.1 0.0218 3.12 1.91-5.09 5.6e-06 TRUE FALSE FALSE FALSE Both 161 1617 GRCh37/hg19 P<=5e-09 2020-06-08 prsweb-phecode193-gwas-catalog-r2019-05-03-x193-p-5e-08-ukb-20200608 prsweb-phecode193-gwas-catalog-r2019-05-03-x193-p-5e-08-ukb-20200608 PRSWEB_PHECODE193_GWAS-Catalog-r2019-05-03-X193_P_5e-08_UKB_20200608 P_5e-08 PRSWEB_PHECODE193_GWAS-Catalog-r2019-05-03-X193_P_5e-08_UKB_20200608 193 Thyroid cancer Binary 19 unique SNPs UKB UK Biobank GWAS Hits GWAS Catalog (2019-05-03) 19198613;22267200;23894154;25855579;28195142 https://www.ncbi.nlm.nih.gov/pubmed/?term=19198613+22267200+23894154+25855579+28195142 10 5.1e-10 0.0530277 0.0803 0.636 0.589-0.682 OR 4.4 1.81-10.7 4.4 1.81-10.7 2.95 1.4-6.22 2.95 1.4-6.22 3.54 2.19-5.73 3.54 2.19-5.73 2.69 1.81-4.02 2.69 1.81-4.02 2.19 1.57-3.04 2.19 1.57-3.04 2.05 1.13-3.72 0.0178 2.71 1.53-4.8 0.000609 4.1 2.37-7.09 4.45e-07 TRUE FALSE FALSE TRUE Both 161 1617 GRCh37/hg19 P<=5e-08 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000631/ScoringFiles/ phewas/PRSWEB_PHECODE193_GWAS-Catalog-r2019-05-03-X193_P_5e-08_UKB_20200608/all.tsv phewas/PRSWEB_PHECODE193_GWAS-Catalog-r2019-05-03-X193_P_5e-08_UKB_20200608/exclusion.tsv 2020-06-08 prsweb-phecode193-gwas-catalog-r2019-05-03-x193-pt-ukb-20200608 prsweb-phecode193-gwas-catalog-r2019-05-03-x193-pt-ukb-20200608 PRSWEB_PHECODE193_GWAS-Catalog-r2019-05-03-X193_PT_UKB_20200608 P&T PRSWEB_PHECODE193_GWAS-Catalog-r2019-05-03-X193_PT_UKB_20200608 193 Thyroid cancer Binary 19 unique SNPs UKB UK Biobank P&T GWAS Catalog (2019-05-03) 19198613;22267200;23894154;25855579;28195142 https://www.ncbi.nlm.nih.gov/pubmed/?term=19198613+22267200+23894154+25855579+28195142 5 1.3e-09 0.0580561 0.0804 0.628 0.582-0.675 OR 4.41 1.81-10.7 4.41 1.81-10.7 3.26 1.58-6.69 3.26 1.58-6.69 3.48 2.16-5.62 3.48 2.16-5.62 2.89 1.95-4.29 2.89 1.95-4.29 2.23 1.6-3.09 2.23 1.6-3.09 2.25 1.23-4.12 0.0086 2.92 1.63-5.21 0.000296 4.4 2.52-7.7 2.04e-07 TRUE FALSE FALSE TRUE Both 161 1617 GRCh37/hg19 P<=1e-16 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000633/ScoringFiles/ phewas/PRSWEB_PHECODE193_GWAS-Catalog-r2019-05-03-X193_PT_UKB_20200608/all.tsv phewas/PRSWEB_PHECODE193_GWAS-Catalog-r2019-05-03-X193_PT_UKB_20200608/exclusion.tsv 2020-06-08 prsweb-phecode194-c3-endocrine-p-5e-05-mgi-20200608 prsweb-phecode194-c3-endocrine-p-5e-05-mgi-20200608 PRSWEB_PHECODE194_C3-ENDOCRINE_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE194_C3-ENDOCRINE_P_5e-05_MGI_20200608 194 Malignant neoplasm of endocrine gland Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 82 0.39 0.000347428 0.0827 0.507 0.447-0.567 OR 4.01 1.27-12.6 4.01 1.27-12.6 2.93 1.18-7.27 2.93 1.18-7.27 2.15 1.1-4.19 2.15 1.1-4.19 1.34 0.745-2.4 1.34 0.745-2.4 1.12 0.726-1.74 1.12 0.726-1.74 0.492 0.27-0.895 0.0202 0.878 0.528-1.46 0.618 0.879 0.527-1.46 0.62 FALSE FALSE FALSE FALSE Both 110 1097 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode194-c3-endocrine-p-5e-06-mgi-20200608 prsweb-phecode194-c3-endocrine-p-5e-06-mgi-20200608 PRSWEB_PHECODE194_C3-ENDOCRINE_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE194_C3-ENDOCRINE_P_5e-06_MGI_20200608 194 Malignant neoplasm of endocrine gland Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 19 0.81 0.000536991 0.0828 0.497 0.445-0.553 OR 1.31 0.222-7.69 1.31 0.222-7.69 2.02 0.709-5.78 2.02 0.709-5.78 1.15 0.499-2.66 1.15 0.499-2.66 1.02 0.538-1.93 1.02 0.538-1.93 1.03 0.66-1.61 1.03 0.66-1.61 1.41 0.807-2.45 0.229 1.22 0.687-2.15 0.504 1.29 0.726-2.28 0.388 FALSE FALSE FALSE FALSE Both 110 1097 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode194-c3-endocrine-p-5e-07-mgi-20200608 prsweb-phecode194-c3-endocrine-p-5e-07-mgi-20200608 PRSWEB_PHECODE194_C3-ENDOCRINE_P_5e-07_MGI_20200608 P_5e-07 PRSWEB_PHECODE194_C3-ENDOCRINE_P_5e-07_MGI_20200608 194 Malignant neoplasm of endocrine gland Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-07) UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 5 0.81 0.00102994 0.0828 0.487 0.434-0.538 OR 1.29 0.219-7.63 1.29 0.219-7.63 1.53 0.476-4.9 1.53 0.476-4.9 0.959 0.389-2.37 0.959 0.389-2.37 0.829 0.416-1.65 0.829 0.416-1.65 1.08 0.695-1.67 1.08 0.695-1.67 1.32 0.763-2.27 0.323 1.09 0.615-1.93 0.769 1.26 0.723-2.2 0.412 FALSE FALSE FALSE FALSE Both 110 1097 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode194-c3-endocrine-pt-mgi-20200608 prsweb-phecode194-c3-endocrine-pt-mgi-20200608 PRSWEB_PHECODE194_C3-ENDOCRINE_PT_MGI_20200608 P&T PRSWEB_PHECODE194_C3-ENDOCRINE_PT_MGI_20200608 194 Malignant neoplasm of endocrine gland Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative P&T UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 123 0.42 0.00443278 0.0828 0.519 0.46-0.579 OR 1.3 0.223-7.59 1.3 0.223-7.59 1.12 0.294-4.25 1.12 0.294-4.25 1.95 0.976-3.89 1.95 0.976-3.89 1.44 0.814-2.54 1.44 0.814-2.54 1.23 0.802-1.89 1.23 0.802-1.89 0.949 0.543-1.66 0.855 1.04 0.596-1.81 0.895 1.18 0.693-2.02 0.538 FALSE FALSE FALSE FALSE Both 110 1097 GRCh37/hg19 P<=7.94e-05 2020-06-08 prsweb-phecode194-c3-endocrine-prs-cs-mgi-20200608 prsweb-phecode194-c3-endocrine-prs-cs-mgi-20200608 PRSWEB_PHECODE194_C3-ENDOCRINE_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE194_C3-ENDOCRINE_PRS-CS_MGI_20200608 194 Malignant neoplasm of endocrine gland Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative PRS-CS UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1061061 0.23 0.00163277 0.0827 0.538 0.484-0.586 OR 0 0-0 0 0-0 0.648 0.12-3.51 0.648 0.12-3.51 0.969 0.394-2.38 0.969 0.394-2.38 1.34 0.745-2.4 1.34 0.745-2.4 0.89 0.563-1.41 0.89 0.563-1.41 1.47 0.814-2.66 0.201 1.96 1.11-3.44 0.0202 1.4 0.764-2.56 0.277 FALSE FALSE FALSE FALSE Both 110 1097 GRCh37/hg19 auto 2020-06-08 prsweb-phecode194-c3-endocrine-lassosum-mgi-20200608 prsweb-phecode194-c3-endocrine-lassosum-mgi-20200608 PRSWEB_PHECODE194_C3-ENDOCRINE_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE194_C3-ENDOCRINE_LASSOSUM_MGI_20200608 194 Malignant neoplasm of endocrine gland Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative lassosum UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 11722 0.46 0.005579 0.0828 0.514 0.458-0.566 OR 2.18 0.522-9.12 2.18 0.522-9.12 1.57 0.492-4.99 1.57 0.492-4.99 1.56 0.737-3.31 1.56 0.737-3.31 1.13 0.611-2.11 1.13 0.611-2.11 1.12 0.728-1.74 1.12 0.728-1.74 0.768 0.444-1.33 0.347 0.831 0.484-1.43 0.503 0.972 0.577-1.64 0.916 FALSE FALSE FALSE FALSE Both 110 1097 GRCh37/hg19 s=0.2;Lambda=0.06158 2020-06-08 prsweb-phecode199-4-ukbb-saige-hrc-x199-4-p-5e-05-mgi-20200608 prsweb-phecode199-4-ukbb-saige-hrc-x199-4-p-5e-05-mgi-20200608 PRSWEB_PHECODE199.4_UKBB-SAIGE-HRC-X199.4_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE199.4_UKBB-SAIGE-HRC-X199.4_P_5e-05_MGI_20200608 199.4 Neurofibromatosis Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 59 0.099 0.000161275 0.082 0.546 0.437-0.652 OR 5.49 0.98-30.8 5.49 0.98-30.8 5.53 1.59-19.3 5.53 1.59-19.3 4.16 1.63-10.6 4.16 1.63-10.6 3.02 1.39-6.57 3.02 1.39-6.57 1.62 0.822-3.19 1.62 0.822-3.19 0.947 0.389-2.31 0.905 0.724 0.273-1.92 0.517 1.24 0.534-2.87 0.618 FALSE FALSE FALSE FALSE Both 40 400 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode199-4-ukbb-saige-hrc-x199-4-p-5e-06-mgi-20200608 prsweb-phecode199-4-ukbb-saige-hrc-x199-4-p-5e-06-mgi-20200608 PRSWEB_PHECODE199.4_UKBB-SAIGE-HRC-X199.4_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE199.4_UKBB-SAIGE-HRC-X199.4_P_5e-06_MGI_20200608 199.4 Neurofibromatosis Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 5 0.12 0.0180792 0.0822 0.519 0.433-0.622 OR 3.4 0.421-27.4 3.4 0.421-27.4 3.06 0.641-14.6 3.06 0.641-14.6 1.72 0.523-5.68 1.72 0.523-5.68 1.7 0.687-4.19 1.7 0.687-4.19 1.65 0.839-3.23 1.65 0.839-3.23 0.824 0.318-2.14 0.691 0.967 0.388-2.41 0.943 1.63 0.686-3.88 0.269 FALSE FALSE FALSE FALSE Both 40 400 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode199-4-ukbb-saige-hrc-x199-4-pt-mgi-20200608 prsweb-phecode199-4-ukbb-saige-hrc-x199-4-pt-mgi-20200608 PRSWEB_PHECODE199.4_UKBB-SAIGE-HRC-X199.4_PT_MGI_20200608 P&T PRSWEB_PHECODE199.4_UKBB-SAIGE-HRC-X199.4_PT_MGI_20200608 199.4 Neurofibromatosis Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative P&T UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 5 0.12 0.0180792 0.0822 0.519 0.433-0.622 OR 3.4 0.421-27.4 3.4 0.421-27.4 3.06 0.641-14.6 3.06 0.641-14.6 1.72 0.523-5.68 1.72 0.523-5.68 1.7 0.687-4.19 1.7 0.687-4.19 1.65 0.839-3.23 1.65 0.839-3.23 0.824 0.318-2.14 0.691 0.967 0.388-2.41 0.943 1.63 0.686-3.88 0.269 FALSE FALSE FALSE FALSE Both 40 400 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode200-ukbb-saige-hrc-x200-p-5e-06-mgi-20200608 prsweb-phecode200-ukbb-saige-hrc-x200-p-5e-06-mgi-20200608 PRSWEB_PHECODE200_UKBB-SAIGE-HRC-X200_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE200_UKBB-SAIGE-HRC-X200_P_5e-06_MGI_20200608 200 Myeloproliferative disease Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 19 0.67 0.00160497 0.0826 0.491 0.465-0.517 OR 1.47 0.637-3.39 1.47 0.637-3.39 1.07 0.544-2.12 1.07 0.544-2.12 1.16 0.76-1.77 1.16 0.76-1.77 1.06 0.768-1.45 1.06 0.768-1.45 1.04 0.83-1.3 1.04 0.83-1.3 0.805 0.607-1.07 0.133 0.99 0.756-1.29 0.94 0.975 0.744-1.28 0.853 FALSE FALSE FALSE FALSE Both 440 4400 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode200-ukbb-saige-hrc-x200-p-5e-07-mgi-20200608 prsweb-phecode200-ukbb-saige-hrc-x200-p-5e-07-mgi-20200608 PRSWEB_PHECODE200_UKBB-SAIGE-HRC-X200_P_5e-07_MGI_20200608 P_5e-07 PRSWEB_PHECODE200_UKBB-SAIGE-HRC-X200_P_5e-07_MGI_20200608 200 Myeloproliferative disease Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative Fixed threshold (5e-07) UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 5 0.46 0.000408673 0.0826 0.493 0.464-0.521 OR 1.46 0.632-3.36 1.46 0.632-3.36 1.42 0.776-2.59 1.42 0.776-2.59 1.41 0.952-2.09 1.41 0.952-2.09 1.19 0.877-1.62 1.19 0.877-1.62 1.09 0.871-1.36 1.09 0.871-1.36 0.971 0.729-1.29 0.84 0.827 0.619-1.11 0.199 0.951 0.719-1.26 0.725 FALSE FALSE FALSE FALSE Both 440 4400 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode200-ukbb-saige-hrc-x200-pt-mgi-20200608 prsweb-phecode200-ukbb-saige-hrc-x200-pt-mgi-20200608 PRSWEB_PHECODE200_UKBB-SAIGE-HRC-X200_PT_MGI_20200608 P&T PRSWEB_PHECODE200_UKBB-SAIGE-HRC-X200_PT_MGI_20200608 200 Myeloproliferative disease Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative P&T UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 25 0.67 0.0019281 0.0826 0.493 0.466-0.519 OR 1.24 0.504-3.05 1.24 0.504-3.05 1.3 0.695-2.42 1.3 0.695-2.42 1.11 0.724-1.71 1.11 0.724-1.71 0.933 0.668-1.3 0.933 0.668-1.3 0.998 0.796-1.25 0.998 0.796-1.25 1.03 0.781-1.36 0.83 1.05 0.798-1.39 0.721 1.03 0.777-1.35 0.858 FALSE FALSE FALSE FALSE Both 440 4400 GRCh37/hg19 P<=7.94e-06 2020-06-08 prsweb-phecode200-1-ukbb-saige-hrc-x200-1-p-5e-05-mgi-20200608 prsweb-phecode200-1-ukbb-saige-hrc-x200-1-p-5e-05-mgi-20200608 PRSWEB_PHECODE200.1_UKBB-SAIGE-HRC-X200.1_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE200.1_UKBB-SAIGE-HRC-X200.1_P_5e-05_MGI_20200608 200.1 Polycythemia vera Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 95 0.89 0.00121692 0.0826 0.501 0.436-0.567 OR 0 0-0 0 0-0 1.31 0.335-5.12 1.31 0.335-5.12 1.27 0.51-3.18 1.27 0.51-3.18 1.24 0.63-2.46 1.24 0.63-2.46 0.986 0.593-1.64 0.986 0.593-1.64 0.712 0.371-1.37 0.308 1.15 0.64-2.08 0.632 0.981 0.531-1.81 0.951 FALSE FALSE FALSE FALSE Both 86 860 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode200-1-ukbb-saige-hrc-x200-1-p-5e-06-mgi-20200608 prsweb-phecode200-1-ukbb-saige-hrc-x200-1-p-5e-06-mgi-20200608 PRSWEB_PHECODE200.1_UKBB-SAIGE-HRC-X200.1_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE200.1_UKBB-SAIGE-HRC-X200.1_P_5e-06_MGI_20200608 200.1 Polycythemia vera Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 19 0.43 6.52746e-05 0.0826 0.513 0.453-0.577 OR 1.58 0.256-9.73 1.58 0.256-9.73 0.786 0.143-4.31 0.786 0.143-4.31 0.549 0.151-2 0.549 0.151-2 0.838 0.385-1.82 0.838 0.385-1.82 1.04 0.632-1.72 1.04 0.632-1.72 1.33 0.666-2.65 0.419 1.9 1.01-3.58 0.0463 1.47 0.761-2.84 0.252 FALSE FALSE FALSE FALSE Both 86 860 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode200-1-ukbb-saige-hrc-x200-1-pt-mgi-20200608 prsweb-phecode200-1-ukbb-saige-hrc-x200-1-pt-mgi-20200608 PRSWEB_PHECODE200.1_UKBB-SAIGE-HRC-X200.1_PT_MGI_20200608 P&T PRSWEB_PHECODE200.1_UKBB-SAIGE-HRC-X200.1_PT_MGI_20200608 200.1 Polycythemia vera Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative P&T UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 95 0.89 0.00121692 0.0826 0.501 0.436-0.567 OR 0 0-0 0 0-0 1.31 0.335-5.12 1.31 0.335-5.12 1.27 0.51-3.18 1.27 0.51-3.18 1.24 0.63-2.46 1.24 0.63-2.46 0.986 0.593-1.64 0.986 0.593-1.64 0.712 0.371-1.37 0.308 1.15 0.64-2.08 0.632 0.981 0.531-1.81 0.951 FALSE FALSE FALSE FALSE Both 86 860 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode201-20001-1052-p-5e-05-mgi-20200608 prsweb-phecode201-20001-1052-p-5e-05-mgi-20200608 PRSWEB_PHECODE201_20001-1052_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE201_20001-1052_P_5e-05_MGI_20200608 201 Cancer code, self-reported: hodgkins lymphoma / hodgkins disease Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 82 0.26 0.0105522 0.083 0.528 0.456-0.601 OR 4.08 1.07-15.5 4.08 1.07-15.5 2.22 0.651-7.58 2.22 0.651-7.58 1.5 0.584-3.85 1.5 0.584-3.85 1.33 0.642-2.75 1.33 0.642-2.75 1.39 0.819-2.35 1.39 0.819-2.35 1.06 0.522-2.15 0.875 1.16 0.572-2.36 0.68 1.44 0.734-2.83 0.287 FALSE FALSE FALSE FALSE Both 71 704 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode201-gwas-catalog-r2019-05-03-x201-p-5e-05-mgi-20200608 prsweb-phecode201-gwas-catalog-r2019-05-03-x201-p-5e-05-mgi-20200608 PRSWEB_PHECODE201_GWAS-Catalog-r2019-05-03-X201_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE201_GWAS-Catalog-r2019-05-03-X201_P_5e-05_MGI_20200608 201 Hodgkin's lymphoma;Nodular sclerosis Hodgkin lymphoma Binary 22 unique SNPs MGI Michigan Genomics Initiative Fixed threshold (5e-05) GWAS Catalog (2019-05-03) 21037568;24149102;24920014;29196614;30194254 https://www.ncbi.nlm.nih.gov/pubmed/?term=21037568+24149102+24920014+29196614+30194254 20 0.0019 0.00760792 0.0821 0.62 0.559-0.688 OR 2.64 0.572-12.2 2.64 0.572-12.2 1.47 0.361-5.96 1.47 0.361-5.96 1.19 0.432-3.29 1.19 0.432-3.29 1.51 0.75-3.03 1.51 0.75-3.03 1.94 1.18-3.19 1.94 1.18-3.19 0.99 0.44-2.22 0.98 1.91 0.916-3.96 0.0845 2.4 1.19-4.85 0.0146 TRUE FALSE FALSE FALSE Both 71 704 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode201-ukbb-saige-hrc-x201-p-5e-05-mgi-20200608 prsweb-phecode201-ukbb-saige-hrc-x201-p-5e-05-mgi-20200608 PRSWEB_PHECODE201_UKBB-SAIGE-HRC-X201_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE201_UKBB-SAIGE-HRC-X201_P_5e-05_MGI_20200608 201 Hodgkin's disease Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 96 0.075 0.00253616 0.0828 0.562 0.489-0.632 OR 1.81 0.285-11.4 1.81 0.285-11.4 1.59 0.396-6.41 1.59 0.396-6.41 1.79 0.741-4.32 1.79 0.741-4.32 1.66 0.844-3.27 1.66 0.844-3.27 1.62 0.971-2.7 1.62 0.971-2.7 1.01 0.484-2.1 0.981 1.35 0.664-2.73 0.409 1.74 0.89-3.41 0.105 FALSE FALSE FALSE FALSE Both 71 704 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode201-20001-1052-p-5e-06-mgi-20200608 prsweb-phecode201-20001-1052-p-5e-06-mgi-20200608 PRSWEB_PHECODE201_20001-1052_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE201_20001-1052_P_5e-06_MGI_20200608 201 Cancer code, self-reported: hodgkins lymphoma / hodgkins disease Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 15 0.0021 0.0133812 0.0823 0.616 0.555-0.68 OR 1.7 0.27-10.7 1.7 0.27-10.7 2.24 0.651-7.71 2.24 0.651-7.71 2.11 0.906-4.92 2.11 0.906-4.92 1.82 0.931-3.54 1.82 0.931-3.54 1.94 1.18-3.21 1.94 1.18-3.21 1.85 0.829-4.12 0.133 2.05 0.917-4.59 0.0803 2.77 1.31-5.87 0.00779 TRUE FALSE FALSE FALSE Both 71 704 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode201-c-hodgkin-lymphoma-p-5e-06-mgi-20200608 prsweb-phecode201-c-hodgkin-lymphoma-p-5e-06-mgi-20200608 PRSWEB_PHECODE201_C-HODGKIN-LYMPHOMA_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE201_C-HODGKIN-LYMPHOMA_P_5e-06_MGI_20200608 201 Hodgkin lymphoma Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 10 0.71 8.78115e-05 0.0831 0.508 0.443-0.573 OR 0 0-0 0 0-0 0.304 0.0173-5.35 0.304 0.0173-5.35 0.641 0.175-2.35 0.641 0.175-2.35 0.727 0.298-1.78 0.727 0.298-1.78 1.03 0.597-1.79 1.03 0.597-1.79 1.17 0.579-2.37 0.658 1.56 0.783-3.1 0.207 1.28 0.631-2.59 0.494 FALSE FALSE FALSE FALSE Both 71 704 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode201-gwas-catalog-r2019-05-03-x201-p-5e-06-mgi-20200608 prsweb-phecode201-gwas-catalog-r2019-05-03-x201-p-5e-06-mgi-20200608 PRSWEB_PHECODE201_GWAS-Catalog-r2019-05-03-X201_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE201_GWAS-Catalog-r2019-05-03-X201_P_5e-06_MGI_20200608 201 Hodgkin's lymphoma;Nodular sclerosis Hodgkin lymphoma Binary 22 unique SNPs MGI Michigan Genomics Initiative Fixed threshold (5e-06) GWAS Catalog (2019-05-03) 21037568;24149102;24920014;29196614;30194254 https://www.ncbi.nlm.nih.gov/pubmed/?term=21037568+24149102+24920014+29196614+30194254 20 0.0019 0.00760792 0.0821 0.62 0.559-0.688 OR 2.64 0.572-12.2 2.64 0.572-12.2 1.47 0.361-5.96 1.47 0.361-5.96 1.19 0.432-3.29 1.19 0.432-3.29 1.51 0.75-3.03 1.51 0.75-3.03 1.94 1.18-3.19 1.94 1.18-3.19 0.99 0.44-2.22 0.98 1.91 0.916-3.96 0.0845 2.4 1.19-4.85 0.0146 TRUE FALSE FALSE FALSE Both 71 704 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode201-ukbb-saige-hrc-x201-p-5e-06-mgi-20200608 prsweb-phecode201-ukbb-saige-hrc-x201-p-5e-06-mgi-20200608 PRSWEB_PHECODE201_UKBB-SAIGE-HRC-X201_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE201_UKBB-SAIGE-HRC-X201_P_5e-06_MGI_20200608 201 Hodgkin's disease Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 7 0.093 0.00182398 0.0828 0.508 0.434-0.589 OR 6.71 2.12-21.2 6.71 2.12-21.2 3.66 1.31-10.3 3.66 1.31-10.3 1.82 0.755-4.37 1.82 0.755-4.37 1.2 0.562-2.55 1.2 0.562-2.55 1.18 0.69-2.01 1.18 0.69-2.01 0.527 0.241-1.15 0.11 1.14 0.598-2.17 0.69 1.02 0.536-1.94 0.951 FALSE FALSE FALSE FALSE Both 71 704 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode201-gwas-catalog-r2019-05-03-x201-p-5e-07-mgi-20200608 prsweb-phecode201-gwas-catalog-r2019-05-03-x201-p-5e-07-mgi-20200608 PRSWEB_PHECODE201_GWAS-Catalog-r2019-05-03-X201_P_5e-07_MGI_20200608 P_5e-07 PRSWEB_PHECODE201_GWAS-Catalog-r2019-05-03-X201_P_5e-07_MGI_20200608 201 Hodgkin's lymphoma;Nodular sclerosis Hodgkin lymphoma Binary 22 unique SNPs MGI Michigan Genomics Initiative Fixed threshold (5e-07) GWAS Catalog (2019-05-03) 21037568;24149102;24920014;29196614;30194254 https://www.ncbi.nlm.nih.gov/pubmed/?term=21037568+24149102+24920014+29196614+30194254 19 0.0031 0.00379941 0.0821 0.618 0.552-0.687 OR 2.69 0.587-12.3 2.69 0.587-12.3 1.48 0.366-5.96 1.48 0.366-5.96 2.07 0.897-4.77 2.07 0.897-4.77 1.68 0.851-3.31 1.68 0.851-3.31 2.42 1.48-3.96 2.42 1.48-3.96 0.881 0.391-1.98 0.76 1.45 0.698-3.03 0.318 2.57 1.31-5.04 0.00607 TRUE FALSE FALSE FALSE Both 71 704 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode201-gwas-catalog-r2019-05-03-x201-p-5e-09-mgi-20200608 prsweb-phecode201-gwas-catalog-r2019-05-03-x201-p-5e-09-mgi-20200608 PRSWEB_PHECODE201_GWAS-Catalog-r2019-05-03-X201_P_5e-09_MGI_20200608 P_5e-09 PRSWEB_PHECODE201_GWAS-Catalog-r2019-05-03-X201_P_5e-09_MGI_20200608 201 Hodgkin's lymphoma;Nodular sclerosis Hodgkin lymphoma Binary 22 unique SNPs MGI Michigan Genomics Initiative Fixed threshold (5e-09) GWAS Catalog (2019-05-03) 21037568;24149102;24920014;29196614;30194254 https://www.ncbi.nlm.nih.gov/pubmed/?term=21037568+24149102+24920014+29196614+30194254 10 0.0021 0.000105868 0.0819 0.611 0.541-0.682 OR 2.86 0.629-13 2.86 0.629-13 2.17 0.637-7.37 2.17 0.637-7.37 1.5 0.587-3.81 1.5 0.587-3.81 1.84 0.957-3.56 1.84 0.957-3.56 2.06 1.25-3.38 2.06 1.25-3.38 0.522 0.216-1.26 0.149 1.86 0.917-3.78 0.0855 2.17 1.11-4.25 0.0242 TRUE FALSE FALSE FALSE Both 71 704 GRCh37/hg19 P<=5e-09 2020-06-08 prsweb-phecode201-gwas-catalog-r2019-05-03-x201-p-5e-08-mgi-20200608 prsweb-phecode201-gwas-catalog-r2019-05-03-x201-p-5e-08-mgi-20200608 PRSWEB_PHECODE201_GWAS-Catalog-r2019-05-03-X201_P_5e-08_MGI_20200608 P_5e-08 PRSWEB_PHECODE201_GWAS-Catalog-r2019-05-03-X201_P_5e-08_MGI_20200608 201 Hodgkin's lymphoma;Nodular sclerosis Hodgkin lymphoma Binary 22 unique SNPs MGI Michigan Genomics Initiative GWAS Hits GWAS Catalog (2019-05-03) 21037568;24149102;24920014;29196614;30194254 https://www.ncbi.nlm.nih.gov/pubmed/?term=21037568+24149102+24920014+29196614+30194254 16 0.0099 0.00186079 0.0824 0.601 0.535-0.671 OR 1.62 0.258-10.1 1.62 0.258-10.1 1.53 0.382-6.13 1.53 0.382-6.13 1.45 0.568-3.72 1.45 0.568-3.72 1.17 0.552-2.48 1.17 0.552-2.48 2.16 1.32-3.54 2.16 1.32-3.54 0.905 0.398-2.06 0.812 1.6 0.777-3.31 0.202 2.39 1.21-4.71 0.0118 TRUE FALSE FALSE TRUE Both 71 704 GRCh37/hg19 P<=5e-08 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000638/ScoringFiles/ phewas/PRSWEB_PHECODE201_GWAS-Catalog-r2019-05-03-X201_P_5e-08_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE201_GWAS-Catalog-r2019-05-03-X201_P_5e-08_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode201-20001-1052-pt-mgi-20200608 prsweb-phecode201-20001-1052-pt-mgi-20200608 PRSWEB_PHECODE201_20001-1052_PT_MGI_20200608 P&T PRSWEB_PHECODE201_20001-1052_PT_MGI_20200608 201 Cancer code, self-reported: hodgkins lymphoma / hodgkins disease Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative P&T UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 65 0.21 0.0196122 0.083 0.533 0.461-0.608 OR 2.79 0.62-12.6 2.79 0.62-12.6 2.25 0.665-7.63 2.25 0.665-7.63 1.17 0.42-3.27 1.17 0.42-3.27 1.52 0.751-3.07 1.52 0.751-3.07 1.57 0.933-2.63 1.57 0.933-2.63 1.15 0.57-2.32 0.696 0.983 0.467-2.07 0.963 1.64 0.841-3.2 0.146 FALSE FALSE FALSE FALSE Both 71 704 GRCh37/hg19 P<=3.98e-05 2020-06-08 prsweb-phecode201-c-hodgkin-lymphoma-pt-mgi-20200608 prsweb-phecode201-c-hodgkin-lymphoma-pt-mgi-20200608 PRSWEB_PHECODE201_C-HODGKIN-LYMPHOMA_PT_MGI_20200608 P&T PRSWEB_PHECODE201_C-HODGKIN-LYMPHOMA_PT_MGI_20200608 201 Hodgkin lymphoma Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative P&T UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 117 0.38 0.0176841 0.083 0.526 0.455-0.593 OR 0 0-0 0 0-0 1.58 0.395-6.31 1.58 0.395-6.31 2.11 0.92-4.82 2.11 0.92-4.82 1.18 0.554-2.5 1.18 0.554-2.5 1.11 0.643-1.9 1.11 0.643-1.9 2.29 1.12-4.67 0.0233 1.37 0.639-2.95 0.417 1.65 0.787-3.45 0.186 FALSE FALSE FALSE FALSE Both 71 704 GRCh37/hg19 P<=9.83e-05 2020-06-08 prsweb-phecode201-gwas-catalog-r2019-05-03-x201-pt-mgi-20200608 prsweb-phecode201-gwas-catalog-r2019-05-03-x201-pt-mgi-20200608 PRSWEB_PHECODE201_GWAS-Catalog-r2019-05-03-X201_PT_MGI_20200608 P&T PRSWEB_PHECODE201_GWAS-Catalog-r2019-05-03-X201_PT_MGI_20200608 201 Hodgkin's lymphoma;Nodular sclerosis Hodgkin lymphoma Binary 22 unique SNPs MGI Michigan Genomics Initiative P&T GWAS Catalog (2019-05-03) 21037568;24149102;24920014;29196614;30194254 https://www.ncbi.nlm.nih.gov/pubmed/?term=21037568+24149102+24920014+29196614+30194254 20 0.0019 0.00760792 0.0821 0.62 0.559-0.688 OR 2.64 0.572-12.2 2.64 0.572-12.2 1.47 0.361-5.96 1.47 0.361-5.96 1.19 0.432-3.29 1.19 0.432-3.29 1.51 0.75-3.03 1.51 0.75-3.03 1.94 1.18-3.19 1.94 1.18-3.19 0.99 0.44-2.22 0.98 1.91 0.916-3.96 0.0845 2.4 1.19-4.85 0.0146 TRUE FALSE FALSE TRUE Both 71 704 GRCh37/hg19 P<=1e-06 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000639/ScoringFiles/ phewas/PRSWEB_PHECODE201_GWAS-Catalog-r2019-05-03-X201_PT_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE201_GWAS-Catalog-r2019-05-03-X201_PT_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode201-ukbb-saige-hrc-x201-pt-mgi-20200608 prsweb-phecode201-ukbb-saige-hrc-x201-pt-mgi-20200608 PRSWEB_PHECODE201_UKBB-SAIGE-HRC-X201_PT_MGI_20200608 P&T PRSWEB_PHECODE201_UKBB-SAIGE-HRC-X201_PT_MGI_20200608 201 Hodgkin's disease Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative P&T UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 17 0.83 0.00759288 0.0831 0.477 0.402-0.546 OR 1.71 0.27-10.8 1.71 0.27-10.8 2.94 0.975-8.86 2.94 0.975-8.86 1.49 0.582-3.79 1.49 0.582-3.79 1.35 0.655-2.79 1.35 0.655-2.79 1.2 0.702-2.05 1.2 0.702-2.05 0.91 0.482-1.72 0.773 0.538 0.26-1.12 0.0956 0.925 0.491-1.74 0.808 FALSE FALSE FALSE FALSE Both 71 704 GRCh37/hg19 P<=7.94e-06 2020-06-08 prsweb-phecode201-20001-1052-prs-cs-mgi-20200608 prsweb-phecode201-20001-1052-prs-cs-mgi-20200608 PRSWEB_PHECODE201_20001-1052_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE201_20001-1052_PRS-CS_MGI_20200608 201 Cancer code, self-reported: hodgkins lymphoma / hodgkins disease Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative PRS-CS UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1047511 0.032 0.012502 0.0826 0.574 0.501-0.642 OR 1.67 0.264-10.5 1.67 0.264-10.5 0.924 0.165-5.19 0.924 0.165-5.19 1.51 0.59-3.85 1.51 0.59-3.85 2.03 1.07-3.84 2.03 1.07-3.84 1.45 0.86-2.43 1.45 0.86-2.43 1.11 0.533-2.32 0.78 1.5 0.746-3.03 0.254 1.66 0.829-3.32 0.152 TRUE FALSE FALSE TRUE Both 71 704 GRCh37/hg19 auto https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000637/ScoringFiles/ phewas/PRSWEB_PHECODE201_20001-1052_PRS-CS_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE201_20001-1052_PRS-CS_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode201-c-hodgkin-lymphoma-prs-cs-mgi-20200608 prsweb-phecode201-c-hodgkin-lymphoma-prs-cs-mgi-20200608 PRSWEB_PHECODE201_C-HODGKIN-LYMPHOMA_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE201_C-HODGKIN-LYMPHOMA_PRS-CS_MGI_20200608 201 Hodgkin lymphoma Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative PRS-CS UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1007370 0.14 0.00233717 0.0828 0.57 0.493-0.644 OR 3.02 0.674-13.5 3.02 0.674-13.5 2.93 0.972-8.81 2.93 0.972-8.81 2.38 1.08-5.27 2.38 1.08-5.27 2.4 1.29-4.44 2.4 1.29-4.44 1.63 0.975-2.71 1.63 0.975-2.71 1.21 0.582-2.51 0.612 1.21 0.585-2.51 0.605 1.83 0.919-3.66 0.0854 FALSE FALSE FALSE FALSE Both 71 704 GRCh37/hg19 auto 2020-06-08 prsweb-phecode201-c81-prs-cs-mgi-20200608 prsweb-phecode201-c81-prs-cs-mgi-20200608 PRSWEB_PHECODE201_C81_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE201_C81_PRS-CS_MGI_20200608 201 Diagnoses - main ICD10: C81 Hodgkin's disease Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative PRS-CS UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 945902 0.3 0.000849859 0.083 0.528 0.451-0.603 OR 4.03 1.07-15.2 4.03 1.07-15.2 2.91 0.958-8.87 2.91 0.958-8.87 2.1 0.915-4.81 2.1 0.915-4.81 1.85 0.96-3.58 1.85 0.96-3.58 1.27 0.749-2.16 1.27 0.749-2.16 1.11 0.56-2.2 0.765 0.949 0.472-1.91 0.884 1.24 0.637-2.4 0.531 FALSE FALSE FALSE FALSE Both 71 704 GRCh37/hg19 auto 2020-06-08 prsweb-phecode201-ukbb-saige-hrc-x201-prs-cs-mgi-20200608 prsweb-phecode201-ukbb-saige-hrc-x201-prs-cs-mgi-20200608 PRSWEB_PHECODE201_UKBB-SAIGE-HRC-X201_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE201_UKBB-SAIGE-HRC-X201_PRS-CS_MGI_20200608 201 Hodgkin's disease Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative PRS-CS UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1119238 0.13 0.00530074 0.0829 0.554 0.485-0.622 OR 0 0-0 0 0-0 0.956 0.17-5.37 0.956 0.17-5.37 0.932 0.303-2.86 0.932 0.303-2.86 1.02 0.462-2.24 1.02 0.462-2.24 1.39 0.822-2.34 1.39 0.822-2.34 2.32 1.08-5 0.0311 1.87 0.832-4.18 0.13 2.97 1.34-6.59 0.00723 FALSE FALSE FALSE FALSE Both 71 704 GRCh37/hg19 auto 2020-06-08 prsweb-phecode201-20001-1052-lassosum-mgi-20200608 prsweb-phecode201-20001-1052-lassosum-mgi-20200608 PRSWEB_PHECODE201_20001-1052_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE201_20001-1052_LASSOSUM_MGI_20200608 201 Cancer code, self-reported: hodgkins lymphoma / hodgkins disease Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative lassosum UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 304734 0.3 0.016509 0.083 0.55 0.475-0.617 OR 2.94 0.645-13.4 2.94 0.645-13.4 1.58 0.394-6.38 1.58 0.394-6.38 1.21 0.441-3.34 1.21 0.441-3.34 1.02 0.464-2.26 1.02 0.464-2.26 1.46 0.87-2.46 1.46 0.87-2.46 0.802 0.391-1.65 0.547 1.04 0.521-2.07 0.915 1.37 0.712-2.65 0.343 FALSE FALSE FALSE FALSE Both 71 704 GRCh37/hg19 s=1;Lambda=0.04833 2020-06-08 prsweb-phecode201-c-hodgkin-lymphoma-lassosum-mgi-20200608 prsweb-phecode201-c-hodgkin-lymphoma-lassosum-mgi-20200608 PRSWEB_PHECODE201_C-HODGKIN-LYMPHOMA_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE201_C-HODGKIN-LYMPHOMA_LASSOSUM_MGI_20200608 201 Hodgkin lymphoma Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative lassosum UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 4599 0.061 0.0159504 0.0827 0.563 0.494-0.633 OR 1.6 0.249-10.2 1.6 0.249-10.2 2.85 0.93-8.72 2.85 0.93-8.72 1.5 0.589-3.84 1.5 0.589-3.84 1.67 0.847-3.3 1.67 0.847-3.3 1.72 1.04-2.85 1.72 1.04-2.85 0.828 0.398-1.72 0.612 0.973 0.484-1.96 0.94 1.69 0.888-3.22 0.11 FALSE FALSE FALSE FALSE Both 71 704 GRCh37/hg19 s=0.9;Lambda=0.1 2020-06-08 prsweb-phecode201-c81-lassosum-mgi-20200608 prsweb-phecode201-c81-lassosum-mgi-20200608 PRSWEB_PHECODE201_C81_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE201_C81_LASSOSUM_MGI_20200608 201 Diagnoses - main ICD10: C81 Hodgkin's disease Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative lassosum UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 31680 0.37 0.0107261 0.0831 0.521 0.455-0.59 OR 1.82 0.289-11.5 1.82 0.289-11.5 1.61 0.402-6.44 1.61 0.402-6.44 0.946 0.307-2.91 0.946 0.307-2.91 1.02 0.466-2.25 1.02 0.466-2.25 1.12 0.654-1.93 1.12 0.654-1.93 1.19 0.607-2.33 0.614 1.06 0.522-2.14 0.877 1.28 0.646-2.55 0.475 FALSE FALSE FALSE FALSE Both 71 704 GRCh37/hg19 s=0.2;Lambda=0.07848 2020-06-08 prsweb-phecode201-ukbb-saige-hrc-x201-lassosum-mgi-20200608 prsweb-phecode201-ukbb-saige-hrc-x201-lassosum-mgi-20200608 PRSWEB_PHECODE201_UKBB-SAIGE-HRC-X201_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE201_UKBB-SAIGE-HRC-X201_LASSOSUM_MGI_20200608 201 Hodgkin's disease Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative lassosum UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1119335 0.04 0.0116363 0.0828 0.569 0.501-0.634 OR 1.64 0.261-10.3 1.64 0.261-10.3 0.898 0.161-5.03 0.898 0.161-5.03 1.24 0.451-3.41 1.24 0.451-3.41 1.54 0.766-3.08 1.54 0.766-3.08 1.67 1.01-2.78 1.67 1.01-2.78 1.99 0.944-4.21 0.0704 1.39 0.629-3.08 0.414 2.6 1.24-5.48 0.0117 TRUE FALSE FALSE TRUE Both 71 704 GRCh37/hg19 s=0.9;Lambda=0.02976 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000640/ScoringFiles/ phewas/PRSWEB_PHECODE201_UKBB-SAIGE-HRC-X201_LASSOSUM_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE201_UKBB-SAIGE-HRC-X201_LASSOSUM_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode201-gwas-catalog-r2019-05-03-x201-p-5e-05-ukb-20200608 prsweb-phecode201-gwas-catalog-r2019-05-03-x201-p-5e-05-ukb-20200608 PRSWEB_PHECODE201_GWAS-Catalog-r2019-05-03-X201_P_5e-05_UKB_20200608 P_5e-05 PRSWEB_PHECODE201_GWAS-Catalog-r2019-05-03-X201_P_5e-05_UKB_20200608 201 Hodgkin's lymphoma;Nodular sclerosis Hodgkin lymphoma Binary 22 unique SNPs UKB UK Biobank Fixed threshold (5e-05) GWAS Catalog (2019-05-03) 21037568;24149102;24920014;29196614;30194254 https://www.ncbi.nlm.nih.gov/pubmed/?term=21037568+24149102+24920014+29196614+30194254 20 0.069 0.0539718 0.0819 0.533 0.476-0.59 OR 2.67 0.783-9.08 2.67 0.783-9.08 2.54 1.04-6.18 2.54 1.04-6.18 2.05 1.08-3.87 2.05 1.08-3.87 1.82 1.11-3 1.82 1.11-3 1.39 0.942-2.06 1.39 0.942-2.06 1.04 0.617-1.75 0.889 0.942 0.552-1.61 0.826 1.35 0.824-2.22 0.233 FALSE FALSE FALSE FALSE Both 126 1270 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode201-gwas-catalog-r2019-05-03-x201-p-5e-06-ukb-20200608 prsweb-phecode201-gwas-catalog-r2019-05-03-x201-p-5e-06-ukb-20200608 PRSWEB_PHECODE201_GWAS-Catalog-r2019-05-03-X201_P_5e-06_UKB_20200608 P_5e-06 PRSWEB_PHECODE201_GWAS-Catalog-r2019-05-03-X201_P_5e-06_UKB_20200608 201 Hodgkin's lymphoma;Nodular sclerosis Hodgkin lymphoma Binary 22 unique SNPs UKB UK Biobank Fixed threshold (5e-06) GWAS Catalog (2019-05-03) 21037568;24149102;24920014;29196614;30194254 https://www.ncbi.nlm.nih.gov/pubmed/?term=21037568+24149102+24920014+29196614+30194254 20 0.069 0.0539718 0.0819 0.533 0.476-0.59 OR 2.67 0.783-9.08 2.67 0.783-9.08 2.54 1.04-6.18 2.54 1.04-6.18 2.05 1.08-3.87 2.05 1.08-3.87 1.82 1.11-3 1.82 1.11-3 1.39 0.942-2.06 1.39 0.942-2.06 1.04 0.617-1.75 0.889 0.942 0.552-1.61 0.826 1.35 0.824-2.22 0.233 FALSE FALSE FALSE FALSE Both 126 1270 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode201-gwas-catalog-r2019-05-03-x201-p-5e-07-ukb-20200608 prsweb-phecode201-gwas-catalog-r2019-05-03-x201-p-5e-07-ukb-20200608 PRSWEB_PHECODE201_GWAS-Catalog-r2019-05-03-X201_P_5e-07_UKB_20200608 P_5e-07 PRSWEB_PHECODE201_GWAS-Catalog-r2019-05-03-X201_P_5e-07_UKB_20200608 201 Hodgkin's lymphoma;Nodular sclerosis Hodgkin lymphoma Binary 22 unique SNPs UKB UK Biobank Fixed threshold (5e-07) GWAS Catalog (2019-05-03) 21037568;24149102;24920014;29196614;30194254 https://www.ncbi.nlm.nih.gov/pubmed/?term=21037568+24149102+24920014+29196614+30194254 19 0.16 0.0483484 0.082 0.522 0.466-0.58 OR 2.67 0.784-9.09 2.67 0.784-9.09 2.13 0.827-5.51 2.13 0.827-5.51 1.68 0.851-3.31 1.68 0.851-3.31 1.72 1.04-2.85 1.72 1.04-2.85 1.5 1.02-2.2 1.5 1.02-2.2 1.28 0.775-2.11 0.334 0.622 0.345-1.12 0.115 1.41 0.864-2.31 0.169 FALSE FALSE FALSE FALSE Both 126 1270 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode201-gwas-catalog-r2019-05-03-x201-p-5e-09-ukb-20200608 prsweb-phecode201-gwas-catalog-r2019-05-03-x201-p-5e-09-ukb-20200608 PRSWEB_PHECODE201_GWAS-Catalog-r2019-05-03-X201_P_5e-09_UKB_20200608 P_5e-09 PRSWEB_PHECODE201_GWAS-Catalog-r2019-05-03-X201_P_5e-09_UKB_20200608 201 Hodgkin's lymphoma;Nodular sclerosis Hodgkin lymphoma Binary 22 unique SNPs UKB UK Biobank Fixed threshold (5e-09) GWAS Catalog (2019-05-03) 21037568;24149102;24920014;29196614;30194254 https://www.ncbi.nlm.nih.gov/pubmed/?term=21037568+24149102+24920014+29196614+30194254 10 0.65 0.0327515 0.0821 0.504 0.453-0.56 OR 1.88 0.463-7.64 1.88 0.463-7.64 1.34 0.426-4.2 1.34 0.426-4.2 0.686 0.26-1.81 0.686 0.26-1.81 1.24 0.711-2.18 1.24 0.711-2.18 1.11 0.738-1.67 1.11 0.738-1.67 0.862 0.515-1.44 0.571 0.936 0.566-1.55 0.798 1.01 0.617-1.65 0.968 FALSE FALSE FALSE FALSE Both 126 1270 GRCh37/hg19 P<=5e-09 2020-06-08 prsweb-phecode201-gwas-catalog-r2019-05-03-x201-p-5e-08-ukb-20200608 prsweb-phecode201-gwas-catalog-r2019-05-03-x201-p-5e-08-ukb-20200608 PRSWEB_PHECODE201_GWAS-Catalog-r2019-05-03-X201_P_5e-08_UKB_20200608 P_5e-08 PRSWEB_PHECODE201_GWAS-Catalog-r2019-05-03-X201_P_5e-08_UKB_20200608 201 Hodgkin's lymphoma;Nodular sclerosis Hodgkin lymphoma Binary 22 unique SNPs UKB UK Biobank GWAS Hits GWAS Catalog (2019-05-03) 21037568;24149102;24920014;29196614;30194254 https://www.ncbi.nlm.nih.gov/pubmed/?term=21037568+24149102+24920014+29196614+30194254 16 0.44 0.0453375 0.0821 0.507 0.449-0.56 OR 1.88 0.464-7.64 1.88 0.464-7.64 1.33 0.425-4.18 1.33 0.425-4.18 1.01 0.441-2.3 1.01 0.441-2.3 1.43 0.838-2.44 1.43 0.838-2.44 1.2 0.804-1.8 1.2 0.804-1.8 0.872 0.523-1.45 0.6 0.837 0.5-1.4 0.499 1.09 0.668-1.78 0.731 FALSE FALSE FALSE FALSE Both 126 1270 GRCh37/hg19 P<=5e-08 2020-06-08 prsweb-phecode201-gwas-catalog-r2019-05-03-x201-pt-ukb-20200608 prsweb-phecode201-gwas-catalog-r2019-05-03-x201-pt-ukb-20200608 PRSWEB_PHECODE201_GWAS-Catalog-r2019-05-03-X201_PT_UKB_20200608 P&T PRSWEB_PHECODE201_GWAS-Catalog-r2019-05-03-X201_PT_UKB_20200608 201 Hodgkin's lymphoma;Nodular sclerosis Hodgkin lymphoma Binary 22 unique SNPs UKB UK Biobank P&T GWAS Catalog (2019-05-03) 21037568;24149102;24920014;29196614;30194254 https://www.ncbi.nlm.nih.gov/pubmed/?term=21037568+24149102+24920014+29196614+30194254 20 0.069 0.0539718 0.0819 0.533 0.476-0.59 OR 2.67 0.783-9.08 2.67 0.783-9.08 2.54 1.04-6.18 2.54 1.04-6.18 2.05 1.08-3.87 2.05 1.08-3.87 1.82 1.11-3 1.82 1.11-3 1.39 0.942-2.06 1.39 0.942-2.06 1.04 0.617-1.75 0.889 0.942 0.552-1.61 0.826 1.35 0.824-2.22 0.233 FALSE FALSE FALSE FALSE Both 126 1270 GRCh37/hg19 P<=1e-06 2020-06-08 prsweb-phecode202-c-lymphoma-p-5e-05-mgi-20200608 prsweb-phecode202-c-lymphoma-p-5e-05-mgi-20200608 PRSWEB_PHECODE202_C-LYMPHOMA_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE202_C-LYMPHOMA_P_5e-05_MGI_20200608 202 Lymphomas Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 140 0.14 0.000805521 0.0827 0.511 0.489-0.534 OR 0.835 0.347-2.01 0.835 0.347-2.01 0.962 0.534-1.73 0.962 0.534-1.73 1.3 0.932-1.82 1.3 0.932-1.82 1.19 0.928-1.54 1.19 0.928-1.54 1.16 0.967-1.39 1.16 0.967-1.39 1.06 0.838-1.33 0.645 0.984 0.778-1.24 0.894 1.17 0.937-1.47 0.162 FALSE FALSE FALSE FALSE Both 643 6422 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode202-c-nonfollicular-lymphoma-p-5e-05-mgi-20200608 prsweb-phecode202-c-nonfollicular-lymphoma-p-5e-05-mgi-20200608 PRSWEB_PHECODE202_C-NONFOLLICULAR-LYMPHOMA_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE202_C-NONFOLLICULAR-LYMPHOMA_P_5e-05_MGI_20200608 202 Non-follicular lymphoma Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 123 0.16 0.00040313 0.0827 0.512 0.489-0.535 OR 0.826 0.343-1.99 0.826 0.343-1.99 1.36 0.818-2.25 1.36 0.818-2.25 1.04 0.72-1.5 1.04 0.72-1.5 1 0.763-1.31 1 0.763-1.31 1.05 0.876-1.27 1.05 0.876-1.27 1.16 0.922-1.47 0.201 1.17 0.925-1.47 0.193 1.17 0.927-1.48 0.185 FALSE FALSE FALSE FALSE Both 643 6422 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode202-c-tnk-lymphoma-p-5e-05-mgi-20200608 prsweb-phecode202-c-tnk-lymphoma-p-5e-05-mgi-20200608 PRSWEB_PHECODE202_C-TNK-LYMPHOMA_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE202_C-TNK-LYMPHOMA_P_5e-05_MGI_20200608 202 Mature T/NK-cell lymphomas Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 50 0.24 0.000405439 0.0827 0.512 0.487-0.535 OR 1.14 0.53-2.44 1.14 0.53-2.44 1.43 0.872-2.35 1.43 0.872-2.35 1.43 1.04-1.98 1.43 1.04-1.98 1.22 0.953-1.57 1.22 0.953-1.57 1.26 1.05-1.5 1.26 1.05-1.5 0.801 0.632-1.02 0.0667 0.909 0.722-1.14 0.413 1.14 0.917-1.42 0.237 FALSE FALSE FALSE FALSE Both 643 6422 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode202-gwas-catalog-r2019-05-03-x202-p-5e-05-mgi-20200608 prsweb-phecode202-gwas-catalog-r2019-05-03-x202-p-5e-05-mgi-20200608 PRSWEB_PHECODE202_GWAS-Catalog-r2019-05-03-X202_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE202_GWAS-Catalog-r2019-05-03-X202_P_5e-05_MGI_20200608 202 Marginal zone lymphoma;Waldenström macroglobulinemia / lymphoplasmacytic lymphoma Binary 7 unique SNPs MGI Michigan Genomics Initiative Fixed threshold (5e-05) GWAS Catalog (2019-05-03) 25569183;30305637 https://www.ncbi.nlm.nih.gov/pubmed/?term=25569183+30305637 7 0.43 0.000432702 0.0827 0.46 0.441-0.48 OR 1.78 0.943-3.36 1.78 0.943-3.36 1.6 0.997-2.57 1.6 0.997-2.57 1.3 0.93-1.81 1.3 0.93-1.81 1.01 0.775-1.32 1.01 0.775-1.32 1 0.832-1.21 1 0.832-1.21 0.913 0.668-1.25 0.568 0.994 0.73-1.35 0.969 0.971 0.712-1.33 0.855 FALSE FALSE FALSE FALSE Both 643 6422 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode202-ukbb-saige-hrc-x202-p-5e-05-mgi-20200608 prsweb-phecode202-ukbb-saige-hrc-x202-p-5e-05-mgi-20200608 PRSWEB_PHECODE202_UKBB-SAIGE-HRC-X202_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE202_UKBB-SAIGE-HRC-X202_P_5e-05_MGI_20200608 202 Cancer of other lymphoid, histiocytic tissue Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 111 0.67 1.22362e-05 0.0827 0.502 0.479-0.526 OR 0.987 0.437-2.23 0.987 0.437-2.23 1.19 0.7-2.04 1.19 0.7-2.04 1.13 0.793-1.6 1.13 0.793-1.6 1.22 0.948-1.57 1.22 0.948-1.57 1.05 0.872-1.26 1.05 0.872-1.26 0.865 0.686-1.09 0.217 0.954 0.761-1.2 0.681 0.984 0.787-1.23 0.89 FALSE FALSE FALSE FALSE Both 643 6422 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode202-c-lymphoma-p-5e-06-mgi-20200608 prsweb-phecode202-c-lymphoma-p-5e-06-mgi-20200608 PRSWEB_PHECODE202_C-LYMPHOMA_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE202_C-LYMPHOMA_P_5e-06_MGI_20200608 202 Lymphomas Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 30 0.071 0.00033857 0.0827 0.509 0.489-0.533 OR 0.836 0.347-2.01 0.836 0.347-2.01 1.04 0.588-1.83 1.04 0.588-1.83 0.94 0.643-1.38 0.94 0.643-1.38 1.09 0.837-1.41 1.09 0.837-1.41 1.17 0.973-1.4 1.17 0.973-1.4 1.07 0.846-1.36 0.566 1.13 0.897-1.43 0.296 1.25 0.997-1.58 0.0532 FALSE FALSE FALSE FALSE Both 643 6422 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode202-c-nonfollicular-lymphoma-p-5e-06-mgi-20200608 prsweb-phecode202-c-nonfollicular-lymphoma-p-5e-06-mgi-20200608 PRSWEB_PHECODE202_C-NONFOLLICULAR-LYMPHOMA_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE202_C-NONFOLLICULAR-LYMPHOMA_P_5e-06_MGI_20200608 202 Non-follicular lymphoma Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 18 0.51 0.000982517 0.0827 0.495 0.472-0.519 OR 0.675 0.257-1.77 0.675 0.257-1.77 1.27 0.757-2.14 1.27 0.757-2.14 1.07 0.749-1.54 1.07 0.749-1.54 1.04 0.794-1.35 1.04 0.794-1.35 1.05 0.876-1.27 1.05 0.876-1.27 1.15 0.911-1.44 0.244 1.04 0.824-1.32 0.736 1.11 0.883-1.4 0.367 FALSE FALSE FALSE FALSE Both 643 6422 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode202-c-primary-lymphoid-hematopoietic-p-5e-06-mgi-20200608 prsweb-phecode202-c-primary-lymphoid-hematopoietic-p-5e-06-mgi-20200608 PRSWEB_PHECODE202_C-PRIMARY-LYMPHOID-HEMATOPOIETIC_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE202_C-PRIMARY-LYMPHOID-HEMATOPOIETIC_P_5e-06_MGI_20200608 202 Primary_lymphoid and hematopoietic malignant neoplasms Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 19 0.55 8.622e-06 0.0827 0.487 0.464-0.509 OR 0.838 0.348-2.02 0.838 0.348-2.02 0.805 0.426-1.52 0.805 0.426-1.52 0.91 0.619-1.34 0.91 0.619-1.34 0.913 0.691-1.21 0.913 0.691-1.21 0.976 0.809-1.18 0.976 0.809-1.18 1.35 1.07-1.71 0.0126 1.31 1.04-1.66 0.0235 1.19 0.936-1.51 0.155 FALSE FALSE FALSE FALSE Both 643 6422 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode202-c-tnk-lymphoma-p-5e-06-mgi-20200608 prsweb-phecode202-c-tnk-lymphoma-p-5e-06-mgi-20200608 PRSWEB_PHECODE202_C-TNK-LYMPHOMA_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE202_C-TNK-LYMPHOMA_P_5e-06_MGI_20200608 202 Mature T/NK-cell lymphomas Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 10 0.35 3.74868e-05 0.0827 0.502 0.479-0.526 OR 1.31 0.636-2.7 1.31 0.636-2.7 1.2 0.703-2.05 1.2 0.703-2.05 1.17 0.825-1.66 1.17 0.825-1.66 1.25 0.972-1.6 1.25 0.972-1.6 1.15 0.959-1.38 1.15 0.959-1.38 0.95 0.755-1.2 0.664 0.894 0.708-1.13 0.345 1.09 0.872-1.36 0.453 FALSE FALSE FALSE FALSE Both 643 6422 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode202-gwas-catalog-r2019-05-03-x202-p-5e-06-mgi-20200608 prsweb-phecode202-gwas-catalog-r2019-05-03-x202-p-5e-06-mgi-20200608 PRSWEB_PHECODE202_GWAS-Catalog-r2019-05-03-X202_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE202_GWAS-Catalog-r2019-05-03-X202_P_5e-06_MGI_20200608 202 Marginal zone lymphoma;Waldenström macroglobulinemia / lymphoplasmacytic lymphoma Binary 7 unique SNPs MGI Michigan Genomics Initiative Fixed threshold (5e-06) GWAS Catalog (2019-05-03) 25569183;30305637 https://www.ncbi.nlm.nih.gov/pubmed/?term=25569183+30305637 7 0.43 0.000432702 0.0827 0.46 0.441-0.48 OR 1.78 0.943-3.36 1.78 0.943-3.36 1.6 0.997-2.57 1.6 0.997-2.57 1.3 0.93-1.81 1.3 0.93-1.81 1.01 0.775-1.32 1.01 0.775-1.32 1 0.832-1.21 1 0.832-1.21 0.913 0.668-1.25 0.568 0.994 0.73-1.35 0.969 0.971 0.712-1.33 0.855 FALSE FALSE FALSE FALSE Both 643 6422 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode202-ukbb-saige-hrc-x202-p-5e-06-mgi-20200608 prsweb-phecode202-ukbb-saige-hrc-x202-p-5e-06-mgi-20200608 PRSWEB_PHECODE202_UKBB-SAIGE-HRC-X202_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE202_UKBB-SAIGE-HRC-X202_P_5e-06_MGI_20200608 202 Cancer of other lymphoid, histiocytic tissue Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 17 0.24 0.000139769 0.0827 0.51 0.486-0.533 OR 0.982 0.435-2.22 0.982 0.435-2.22 0.873 0.475-1.61 0.873 0.475-1.61 0.999 0.69-1.45 0.999 0.69-1.45 0.945 0.718-1.24 0.945 0.718-1.24 1.1 0.913-1.32 1.1 0.913-1.32 1.22 0.963-1.54 0.1 1.15 0.911-1.46 0.237 1.23 0.973-1.55 0.0839 FALSE FALSE FALSE FALSE Both 643 6422 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode202-c-lymphoma-p-5e-07-mgi-20200608 prsweb-phecode202-c-lymphoma-p-5e-07-mgi-20200608 PRSWEB_PHECODE202_C-LYMPHOMA_P_5e-07_MGI_20200608 P_5e-07 PRSWEB_PHECODE202_C-LYMPHOMA_P_5e-07_MGI_20200608 202 Lymphomas Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-07) UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 8 0.3 0.000959855 0.0827 0.493 0.47-0.515 OR 1.14 0.532-2.45 1.14 0.532-2.45 1.28 0.759-2.15 1.28 0.759-2.15 1.1 0.773-1.58 1.1 0.773-1.58 1.03 0.793-1.35 1.03 0.793-1.35 0.977 0.81-1.18 0.977 0.81-1.18 1.32 1.05-1.67 0.0194 1.25 0.985-1.58 0.0659 1.14 0.9-1.45 0.272 FALSE FALSE FALSE FALSE Both 643 6422 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode202-c-primary-lymphoid-hematopoietic-p-5e-07-mgi-20200608 prsweb-phecode202-c-primary-lymphoid-hematopoietic-p-5e-07-mgi-20200608 PRSWEB_PHECODE202_C-PRIMARY-LYMPHOID-HEMATOPOIETIC_P_5e-07_MGI_20200608 P_5e-07 PRSWEB_PHECODE202_C-PRIMARY-LYMPHOID-HEMATOPOIETIC_P_5e-07_MGI_20200608 202 Primary_lymphoid and hematopoietic malignant neoplasms Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-07) UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 8 0.6 0.000144789 0.0827 0.477 0.456-0.497 OR 0.686 0.261-1.8 0.686 0.261-1.8 0.965 0.536-1.74 0.965 0.536-1.74 1.01 0.695-1.46 1.01 0.695-1.46 0.932 0.707-1.23 0.932 0.707-1.23 1.03 0.853-1.24 1.03 0.853-1.24 1 0.787-1.27 0.998 1.11 0.876-1.4 0.392 1.07 0.842-1.35 0.592 FALSE FALSE FALSE FALSE Both 643 6422 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode202-gwas-catalog-r2019-05-03-x202-p-5e-07-mgi-20200608 prsweb-phecode202-gwas-catalog-r2019-05-03-x202-p-5e-07-mgi-20200608 PRSWEB_PHECODE202_GWAS-Catalog-r2019-05-03-X202_P_5e-07_MGI_20200608 P_5e-07 PRSWEB_PHECODE202_GWAS-Catalog-r2019-05-03-X202_P_5e-07_MGI_20200608 202 Marginal zone lymphoma;Waldenström macroglobulinemia / lymphoplasmacytic lymphoma Binary 7 unique SNPs MGI Michigan Genomics Initiative Fixed threshold (5e-07) GWAS Catalog (2019-05-03) 25569183;30305637 https://www.ncbi.nlm.nih.gov/pubmed/?term=25569183+30305637 5 0.43 0.000323159 0.0827 0.456 0.438-0.476 OR 1.94 1.05-3.58 1.94 1.05-3.58 1.6 0.997-2.57 1.6 0.997-2.57 1.29 0.922-1.8 1.29 0.922-1.8 1.07 0.82-1.39 1.07 0.82-1.39 1 0.833-1.21 1 0.833-1.21 1.12 0.757-1.66 0.567 1.12 0.746-1.67 0.588 1.17 0.783-1.74 0.449 FALSE FALSE FALSE FALSE Both 643 6422 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode202-ukbb-saige-hrc-x202-p-5e-07-mgi-20200608 prsweb-phecode202-ukbb-saige-hrc-x202-p-5e-07-mgi-20200608 PRSWEB_PHECODE202_UKBB-SAIGE-HRC-X202_P_5e-07_MGI_20200608 P_5e-07 PRSWEB_PHECODE202_UKBB-SAIGE-HRC-X202_P_5e-07_MGI_20200608 202 Cancer of other lymphoid, histiocytic tissue Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative Fixed threshold (5e-07) UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 6 0.056 7.28541e-05 0.0827 0.511 0.489-0.537 OR 0.996 0.441-2.25 0.996 0.441-2.25 1.04 0.592-1.84 1.04 0.592-1.84 1.07 0.748-1.54 1.07 0.748-1.54 1.09 0.836-1.41 1.09 0.836-1.41 1.19 0.991-1.42 1.19 0.991-1.42 1.22 0.957-1.55 0.108 1.23 0.968-1.57 0.0901 1.37 1.09-1.74 0.00801 FALSE FALSE FALSE FALSE Both 643 6422 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode202-c-lymphoma-pt-mgi-20200608 prsweb-phecode202-c-lymphoma-pt-mgi-20200608 PRSWEB_PHECODE202_C-LYMPHOMA_PT_MGI_20200608 P&T PRSWEB_PHECODE202_C-LYMPHOMA_PT_MGI_20200608 202 Lymphomas Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative P&T UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 14 0.19 0.00170198 0.0827 0.496 0.474-0.52 OR 0.982 0.435-2.22 0.982 0.435-2.22 1.04 0.589-1.83 1.04 0.589-1.83 1.3 0.931-1.82 1.3 0.931-1.82 1.02 0.777-1.33 1.02 0.777-1.33 0.992 0.823-1.2 0.992 0.823-1.2 1.14 0.903-1.44 0.269 1.23 0.978-1.55 0.0773 1.11 0.879-1.41 0.378 FALSE FALSE FALSE FALSE Both 643 6422 GRCh37/hg19 P<=1e-06 2020-06-08 prsweb-phecode202-c-nonfollicular-lymphoma-pt-mgi-20200608 prsweb-phecode202-c-nonfollicular-lymphoma-pt-mgi-20200608 PRSWEB_PHECODE202_C-NONFOLLICULAR-LYMPHOMA_PT_MGI_20200608 P&T PRSWEB_PHECODE202_C-NONFOLLICULAR-LYMPHOMA_PT_MGI_20200608 202 Non-follicular lymphoma Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative P&T UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 12 0.45 0.00172789 0.0827 0.496 0.472-0.52 OR 1.59 0.824-3.09 1.59 0.824-3.09 1.75 1.11-2.77 1.75 1.11-2.77 1.2 0.853-1.7 1.2 0.853-1.7 0.983 0.749-1.29 0.983 0.749-1.29 1.05 0.87-1.26 1.05 0.87-1.26 0.846 0.669-1.07 0.165 1.06 0.844-1.32 0.637 1.01 0.808-1.27 0.909 FALSE FALSE FALSE FALSE Both 643 6422 GRCh37/hg19 P<=3.16e-06 2020-06-08 prsweb-phecode202-c-tnk-lymphoma-pt-mgi-20200608 prsweb-phecode202-c-tnk-lymphoma-pt-mgi-20200608 PRSWEB_PHECODE202_C-TNK-LYMPHOMA_PT_MGI_20200608 P&T PRSWEB_PHECODE202_C-TNK-LYMPHOMA_PT_MGI_20200608 202 Mature T/NK-cell lymphomas Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative P&T UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 80 0.91 0.000994522 0.0827 0.498 0.474-0.52 OR 1.13 0.527-2.43 1.13 0.527-2.43 1.59 0.988-2.55 1.59 0.988-2.55 1.23 0.877-1.73 1.23 0.877-1.73 1.15 0.894-1.49 1.15 0.894-1.49 1.04 0.867-1.25 1.04 0.867-1.25 0.859 0.684-1.08 0.195 0.883 0.704-1.11 0.285 0.956 0.765-1.19 0.692 FALSE FALSE FALSE FALSE Both 643 6422 GRCh37/hg19 P<=9.78e-05 2020-06-08 prsweb-phecode202-gwas-catalog-r2019-05-03-x202-pt-mgi-20200608 prsweb-phecode202-gwas-catalog-r2019-05-03-x202-pt-mgi-20200608 PRSWEB_PHECODE202_GWAS-Catalog-r2019-05-03-X202_PT_MGI_20200608 P&T PRSWEB_PHECODE202_GWAS-Catalog-r2019-05-03-X202_PT_MGI_20200608 202 Marginal zone lymphoma;Waldenström macroglobulinemia / lymphoplasmacytic lymphoma Binary 7 unique SNPs MGI Michigan Genomics Initiative P&T GWAS Catalog (2019-05-03) 25569183;30305637 https://www.ncbi.nlm.nih.gov/pubmed/?term=25569183+30305637 7 0.43 0.000432702 0.0827 0.46 0.441-0.48 OR 1.78 0.943-3.36 1.78 0.943-3.36 1.6 0.997-2.57 1.6 0.997-2.57 1.3 0.93-1.81 1.3 0.93-1.81 1.01 0.775-1.32 1.01 0.775-1.32 1 0.832-1.21 1 0.832-1.21 0.913 0.668-1.25 0.568 0.994 0.73-1.35 0.969 0.971 0.712-1.33 0.855 FALSE FALSE FALSE FALSE Both 643 6422 GRCh37/hg19 P<=3e-06 2020-06-08 prsweb-phecode202-ukbb-saige-hrc-x202-pt-mgi-20200608 prsweb-phecode202-ukbb-saige-hrc-x202-pt-mgi-20200608 PRSWEB_PHECODE202_UKBB-SAIGE-HRC-X202_PT_MGI_20200608 P&T PRSWEB_PHECODE202_UKBB-SAIGE-HRC-X202_PT_MGI_20200608 202 Cancer of other lymphoid, histiocytic tissue Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative P&T UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 10 0.1 0.000407644 0.0827 0.51 0.487-0.533 OR 1.28 0.623-2.65 1.28 0.623-2.65 1.11 0.641-1.93 1.11 0.641-1.93 1.09 0.766-1.56 1.09 0.766-1.56 0.978 0.746-1.28 0.978 0.746-1.28 0.969 0.803-1.17 0.969 0.803-1.17 1.02 0.797-1.29 0.903 1.47 1.17-1.84 0.000879 1.12 0.885-1.42 0.342 FALSE FALSE FALSE FALSE Both 643 6422 GRCh37/hg19 P<=2e-06 2020-06-08 prsweb-phecode202-c-lymphoma-prs-cs-mgi-20200608 prsweb-phecode202-c-lymphoma-prs-cs-mgi-20200608 PRSWEB_PHECODE202_C-LYMPHOMA_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE202_C-LYMPHOMA_PRS-CS_MGI_20200608 202 Lymphomas Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative PRS-CS UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1109478 0.55 0.000250168 0.0827 0.505 0.482-0.527 OR 1.16 0.539-2.49 1.16 0.539-2.49 1.28 0.762-2.15 1.28 0.762-2.15 1.07 0.749-1.54 1.07 0.749-1.54 1.02 0.779-1.33 1.02 0.779-1.33 1 0.833-1.21 1 0.833-1.21 1.21 0.958-1.52 0.111 1.18 0.932-1.49 0.172 1.14 0.898-1.44 0.289 FALSE FALSE FALSE FALSE Both 643 6422 GRCh37/hg19 auto 2020-06-08 prsweb-phecode202-ukbb-saige-hrc-x202-prs-cs-mgi-20200608 prsweb-phecode202-ukbb-saige-hrc-x202-prs-cs-mgi-20200608 PRSWEB_PHECODE202_UKBB-SAIGE-HRC-X202_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE202_UKBB-SAIGE-HRC-X202_PRS-CS_MGI_20200608 202 Cancer of other lymphoid, histiocytic tissue Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative PRS-CS UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1119238 0.56 0.000140408 0.0827 0.51 0.487-0.531 OR 1.31 0.635-2.7 1.31 0.635-2.7 0.883 0.48-1.62 0.883 0.48-1.62 0.873 0.59-1.29 0.873 0.59-1.29 1.05 0.806-1.37 1.05 0.806-1.37 1.09 0.906-1.31 1.09 0.906-1.31 1.03 0.817-1.3 0.794 1.08 0.859-1.36 0.504 1.13 0.9-1.42 0.292 FALSE FALSE FALSE FALSE Both 643 6422 GRCh37/hg19 auto 2020-06-08 prsweb-phecode202-c-lymphoma-lassosum-mgi-20200608 prsweb-phecode202-c-lymphoma-lassosum-mgi-20200608 PRSWEB_PHECODE202_C-LYMPHOMA_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE202_C-LYMPHOMA_LASSOSUM_MGI_20200608 202 Lymphomas Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative lassosum UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 215 0.43 0.000456261 0.0827 0.478 0.458-0.501 OR 0.993 0.44-2.24 0.993 0.44-2.24 0.882 0.479-1.62 0.882 0.479-1.62 1.11 0.774-1.58 1.11 0.774-1.58 1.14 0.884-1.48 1.14 0.884-1.48 0.998 0.828-1.2 0.998 0.828-1.2 1.17 0.924-1.47 0.196 1.2 0.955-1.52 0.116 1.13 0.891-1.43 0.318 FALSE FALSE FALSE FALSE Both 643 6422 GRCh37/hg19 s=0.2;Lambda=0.04833 2020-06-08 prsweb-phecode202-c-nonfollicular-lymphoma-lassosum-mgi-20200608 prsweb-phecode202-c-nonfollicular-lymphoma-lassosum-mgi-20200608 PRSWEB_PHECODE202_C-NONFOLLICULAR-LYMPHOMA_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE202_C-NONFOLLICULAR-LYMPHOMA_LASSOSUM_MGI_20200608 202 Non-follicular lymphoma Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative lassosum UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 238 0.33 0.000889991 0.0827 0.495 0.472-0.519 OR 0.989 0.438-2.23 0.989 0.438-2.23 1.19 0.698-2.03 1.19 0.698-2.03 1.3 0.929-1.81 1.3 0.929-1.81 1.23 0.955-1.58 1.23 0.955-1.58 1.06 0.882-1.28 1.06 0.882-1.28 1.09 0.864-1.36 0.478 0.98 0.776-1.24 0.866 1.09 0.864-1.36 0.48 FALSE FALSE FALSE FALSE Both 643 6422 GRCh37/hg19 s=0.9;Lambda=0.07848 2020-06-08 prsweb-phecode202-ukbb-saige-hrc-x202-lassosum-mgi-20200608 prsweb-phecode202-ukbb-saige-hrc-x202-lassosum-mgi-20200608 PRSWEB_PHECODE202_UKBB-SAIGE-HRC-X202_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE202_UKBB-SAIGE-HRC-X202_LASSOSUM_MGI_20200608 202 Cancer of other lymphoid, histiocytic tissue Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative lassosum UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 39308 0.36 0.000876834 0.0827 0.509 0.484-0.535 OR 2.41 1.37-4.24 2.41 1.37-4.24 1.6 0.996-2.57 1.6 0.996-2.57 1.31 0.935-1.82 1.31 0.935-1.82 1.25 0.972-1.6 1.25 0.972-1.6 1.13 0.943-1.36 1.13 0.943-1.36 0.913 0.723-1.15 0.445 1.01 0.803-1.27 0.937 1.09 0.874-1.37 0.433 FALSE FALSE FALSE FALSE Both 643 6422 GRCh37/hg19 s=0.2;Lambda=0.02336 2020-06-08 prsweb-phecode202-gwas-catalog-r2019-05-03-x202-p-5e-05-ukb-20200608 prsweb-phecode202-gwas-catalog-r2019-05-03-x202-p-5e-05-ukb-20200608 PRSWEB_PHECODE202_GWAS-Catalog-r2019-05-03-X202_P_5e-05_UKB_20200608 P_5e-05 PRSWEB_PHECODE202_GWAS-Catalog-r2019-05-03-X202_P_5e-05_UKB_20200608 202 Marginal zone lymphoma;Waldenström macroglobulinemia / lymphoplasmacytic lymphoma Binary 7 unique SNPs Quartile analysis was unavailable in the source output. UKB UK Biobank Fixed threshold (5e-05) GWAS Catalog (2019-05-03) 25569183;30305637 https://www.ncbi.nlm.nih.gov/pubmed/?term=25569183+30305637 7 1.8e-07 0.0010617 0.0822 0.493 0.479-0.508 OR 2.13 1.38-3.28 2.13 1.38-3.28 1.88 1.35-2.63 1.88 1.35-2.63 1.43 1.13-1.81 1.43 1.13-1.81 1.34 1.13-1.6 1.34 1.13-1.6 1.3 1.14-1.48 1.3 1.14-1.48 TRUE FALSE FALSE FALSE Both 1143 11478 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode202-gwas-catalog-r2019-05-03-x202-p-5e-06-ukb-20200608 prsweb-phecode202-gwas-catalog-r2019-05-03-x202-p-5e-06-ukb-20200608 PRSWEB_PHECODE202_GWAS-Catalog-r2019-05-03-X202_P_5e-06_UKB_20200608 P_5e-06 PRSWEB_PHECODE202_GWAS-Catalog-r2019-05-03-X202_P_5e-06_UKB_20200608 202 Marginal zone lymphoma;Waldenström macroglobulinemia / lymphoplasmacytic lymphoma Binary 7 unique SNPs Quartile analysis was unavailable in the source output. UKB UK Biobank Fixed threshold (5e-06) GWAS Catalog (2019-05-03) 25569183;30305637 https://www.ncbi.nlm.nih.gov/pubmed/?term=25569183+30305637 7 1.8e-07 0.0010617 0.0822 0.493 0.479-0.508 OR 2.13 1.38-3.28 2.13 1.38-3.28 1.88 1.35-2.63 1.88 1.35-2.63 1.43 1.13-1.81 1.43 1.13-1.81 1.34 1.13-1.6 1.34 1.13-1.6 1.3 1.14-1.48 1.3 1.14-1.48 TRUE FALSE FALSE FALSE Both 1143 11478 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode202-gwas-catalog-r2019-05-03-x202-p-5e-07-ukb-20200608 prsweb-phecode202-gwas-catalog-r2019-05-03-x202-p-5e-07-ukb-20200608 PRSWEB_PHECODE202_GWAS-Catalog-r2019-05-03-X202_P_5e-07_UKB_20200608 P_5e-07 PRSWEB_PHECODE202_GWAS-Catalog-r2019-05-03-X202_P_5e-07_UKB_20200608 202 Marginal zone lymphoma;Waldenström macroglobulinemia / lymphoplasmacytic lymphoma Binary 7 unique SNPs Quartile analysis was unavailable in the source output. UKB UK Biobank Fixed threshold (5e-07) GWAS Catalog (2019-05-03) 25569183;30305637 https://www.ncbi.nlm.nih.gov/pubmed/?term=25569183+30305637 5 1.7e-07 0.00107956 0.0822 0.49 0.476-0.505 OR 1.97 1.25-3.12 1.97 1.25-3.12 1.73 1.28-2.34 1.73 1.28-2.34 1.46 1.15-1.85 1.46 1.15-1.85 1.35 1.13-1.62 1.35 1.13-1.62 1.34 1.17-1.52 1.34 1.17-1.52 TRUE FALSE FALSE FALSE Both 1143 11478 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode202-gwas-catalog-r2019-05-03-x202-pt-ukb-20200608 prsweb-phecode202-gwas-catalog-r2019-05-03-x202-pt-ukb-20200608 PRSWEB_PHECODE202_GWAS-Catalog-r2019-05-03-X202_PT_UKB_20200608 P&T PRSWEB_PHECODE202_GWAS-Catalog-r2019-05-03-X202_PT_UKB_20200608 202 Marginal zone lymphoma;Waldenström macroglobulinemia / lymphoplasmacytic lymphoma Binary 7 unique SNPs Quartile analysis was unavailable in the source output. UKB UK Biobank P&T GWAS Catalog (2019-05-03) 25569183;30305637 https://www.ncbi.nlm.nih.gov/pubmed/?term=25569183+30305637 5 1.7e-07 0.00107956 0.0822 0.49 0.476-0.505 OR 1.97 1.25-3.12 1.97 1.25-3.12 1.73 1.28-2.34 1.73 1.28-2.34 1.46 1.15-1.85 1.46 1.15-1.85 1.35 1.13-1.62 1.35 1.13-1.62 1.34 1.17-1.52 1.34 1.17-1.52 TRUE FALSE FALSE FALSE Both 1143 11478 GRCh37/hg19 P<=5e-07 phewas/PRSWEB_PHECODE202_GWAS-Catalog-r2019-05-03-X202_PT_UKB_20200608/all.tsv phewas/PRSWEB_PHECODE202_GWAS-Catalog-r2019-05-03-X202_PT_UKB_20200608/exclusion.tsv 2020-06-08 prsweb-phecode202-2-c-nonhodgkin-nas-p-5e-05-mgi-20200608 prsweb-phecode202-2-c-nonhodgkin-nas-p-5e-05-mgi-20200608 PRSWEB_PHECODE202.2_C-NONHODGKIN-NAS_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE202.2_C-NONHODGKIN-NAS_P_5e-05_MGI_20200608 202.2 Other and unspecified types of non-Hodgkin lymphoma Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 80 0.52 6.12134e-05 0.0827 0.505 0.48-0.53 OR 0.747 0.284-1.97 0.747 0.284-1.97 0.793 0.406-1.55 0.793 0.406-1.55 1.01 0.682-1.48 1.01 0.682-1.48 1.14 0.868-1.49 1.14 0.868-1.49 1.08 0.893-1.31 1.08 0.893-1.31 1.08 0.844-1.37 0.555 1.07 0.836-1.36 0.604 1.12 0.877-1.42 0.37 FALSE FALSE FALSE FALSE Both 581 5803 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode202-2-c83-p-5e-05-mgi-20200608 prsweb-phecode202-2-c83-p-5e-05-mgi-20200608 PRSWEB_PHECODE202.2_C83_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE202.2_C83_P_5e-05_MGI_20200608 202.2 Diagnoses - main ICD10: C83 Diffuse non-Hodgkin's lymphoma Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 119 0.19 0.00197129 0.0827 0.513 0.488-0.539 OR 1.26 0.584-2.72 1.26 0.584-2.72 1.41 0.837-2.38 1.41 0.837-2.38 1.31 0.92-1.86 1.31 0.92-1.86 1.24 0.955-1.62 1.24 0.955-1.62 1.18 0.979-1.43 1.18 0.979-1.43 0.876 0.682-1.13 0.304 1.09 0.856-1.38 0.492 1.16 0.919-1.47 0.207 FALSE FALSE FALSE FALSE Both 581 5803 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode202-2-gwas-catalog-r2019-05-03-x202-2-p-5e-05-mgi-20200608 prsweb-phecode202-2-gwas-catalog-r2019-05-03-x202-2-p-5e-05-mgi-20200608 PRSWEB_PHECODE202.2_GWAS-Catalog-r2019-05-03-X202.2_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE202.2_GWAS-Catalog-r2019-05-03-X202.2_P_5e-05_MGI_20200608 202.2 Diffuse large B cell lymphoma;Follicular lymphoma Binary 19 unique SNPs MGI Michigan Genomics Initiative Fixed threshold (5e-05) GWAS Catalog (2019-05-03) 19620980;20639881;21533074;25261932;25279986 https://www.ncbi.nlm.nih.gov/pubmed/?term=19620980+20639881+21533074+25261932+25279986 18 0.34 0.00570966 0.0827 0.504 0.48-0.527 OR 1.58 0.787-3.16 1.58 0.787-3.16 1.48 0.89-2.48 1.48 0.89-2.48 1.22 0.853-1.75 1.22 0.853-1.75 1.02 0.769-1.35 1.02 0.769-1.35 1.03 0.851-1.26 1.03 0.851-1.26 1.04 0.813-1.32 0.776 1.03 0.808-1.31 0.808 1.07 0.843-1.37 0.567 FALSE FALSE FALSE FALSE Both 581 5803 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode202-2-c83-p-5e-06-mgi-20200608 prsweb-phecode202-2-c83-p-5e-06-mgi-20200608 PRSWEB_PHECODE202.2_C83_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE202.2_C83_P_5e-06_MGI_20200608 202.2 Diagnoses - main ICD10: C83 Diffuse non-Hodgkin's lymphoma Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 18 0.33 0.000542874 0.0827 0.496 0.473-0.521 OR 1.26 0.585-2.73 1.26 0.585-2.73 1.24 0.713-2.16 1.24 0.713-2.16 0.905 0.602-1.36 0.905 0.602-1.36 1.11 0.84-1.45 1.11 0.84-1.45 1.05 0.864-1.27 1.05 0.864-1.27 1.13 0.887-1.44 0.321 1.1 0.861-1.4 0.445 1.13 0.884-1.44 0.332 FALSE FALSE FALSE FALSE Both 581 5803 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode202-2-gwas-catalog-r2019-05-03-x202-2-p-5e-06-mgi-20200608 prsweb-phecode202-2-gwas-catalog-r2019-05-03-x202-2-p-5e-06-mgi-20200608 PRSWEB_PHECODE202.2_GWAS-Catalog-r2019-05-03-X202.2_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE202.2_GWAS-Catalog-r2019-05-03-X202.2_P_5e-06_MGI_20200608 202.2 Diffuse large B cell lymphoma;Follicular lymphoma Binary 19 unique SNPs MGI Michigan Genomics Initiative Fixed threshold (5e-06) GWAS Catalog (2019-05-03) 19620980;20639881;21533074;25261932;25279986 https://www.ncbi.nlm.nih.gov/pubmed/?term=19620980+20639881+21533074+25261932+25279986 16 0.63 0.00497357 0.0827 0.494 0.471-0.519 OR 1.58 0.79-3.17 1.58 0.79-3.17 1.22 0.701-2.13 1.22 0.701-2.13 1.19 0.825-1.71 1.19 0.825-1.71 1.08 0.819-1.42 1.08 0.819-1.42 1.04 0.859-1.27 1.04 0.859-1.27 0.921 0.725-1.17 0.498 0.888 0.697-1.13 0.334 0.982 0.775-1.24 0.877 FALSE FALSE FALSE FALSE Both 581 5803 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode202-2-gwas-catalog-r2019-05-03-x202-2-p-5e-07-mgi-20200608 prsweb-phecode202-2-gwas-catalog-r2019-05-03-x202-2-p-5e-07-mgi-20200608 PRSWEB_PHECODE202.2_GWAS-Catalog-r2019-05-03-X202.2_P_5e-07_MGI_20200608 P_5e-07 PRSWEB_PHECODE202.2_GWAS-Catalog-r2019-05-03-X202.2_P_5e-07_MGI_20200608 202.2 Diffuse large B cell lymphoma;Follicular lymphoma Binary 19 unique SNPs MGI Michigan Genomics Initiative Fixed threshold (5e-07) GWAS Catalog (2019-05-03) 19620980;20639881;21533074;25261932;25279986 https://www.ncbi.nlm.nih.gov/pubmed/?term=19620980+20639881+21533074+25261932+25279986 16 0.63 0.00497357 0.0827 0.494 0.471-0.519 OR 1.58 0.79-3.17 1.58 0.79-3.17 1.22 0.701-2.13 1.22 0.701-2.13 1.19 0.825-1.71 1.19 0.825-1.71 1.08 0.819-1.42 1.08 0.819-1.42 1.04 0.859-1.27 1.04 0.859-1.27 0.921 0.725-1.17 0.498 0.888 0.697-1.13 0.334 0.982 0.775-1.24 0.877 FALSE FALSE FALSE FALSE Both 581 5803 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode202-2-gwas-catalog-r2019-05-03-x202-2-p-5e-09-mgi-20200608 prsweb-phecode202-2-gwas-catalog-r2019-05-03-x202-2-p-5e-09-mgi-20200608 PRSWEB_PHECODE202.2_GWAS-Catalog-r2019-05-03-X202.2_P_5e-09_MGI_20200608 P_5e-09 PRSWEB_PHECODE202.2_GWAS-Catalog-r2019-05-03-X202.2_P_5e-09_MGI_20200608 202.2 Diffuse large B cell lymphoma;Follicular lymphoma Binary 19 unique SNPs MGI Michigan Genomics Initiative Fixed threshold (5e-09) GWAS Catalog (2019-05-03) 19620980;20639881;21533074;25261932;25279986 https://www.ncbi.nlm.nih.gov/pubmed/?term=19620980+20639881+21533074+25261932+25279986 11 0.47 0.00513519 0.0827 0.498 0.476-0.522 OR 0.912 0.377-2.21 0.912 0.377-2.21 1.05 0.583-1.9 1.05 0.583-1.9 1.04 0.711-1.53 1.04 0.711-1.53 1.16 0.885-1.52 1.16 0.885-1.52 1.11 0.917-1.35 1.11 0.917-1.35 1.03 0.813-1.32 0.781 0.961 0.752-1.23 0.749 1.12 0.88-1.42 0.363 FALSE FALSE FALSE FALSE Both 581 5803 GRCh37/hg19 P<=5e-09 2020-06-08 prsweb-phecode202-2-gwas-catalog-r2019-05-03-x202-2-p-5e-08-mgi-20200608 prsweb-phecode202-2-gwas-catalog-r2019-05-03-x202-2-p-5e-08-mgi-20200608 PRSWEB_PHECODE202.2_GWAS-Catalog-r2019-05-03-X202.2_P_5e-08_MGI_20200608 P_5e-08 PRSWEB_PHECODE202.2_GWAS-Catalog-r2019-05-03-X202.2_P_5e-08_MGI_20200608 202.2 Diffuse large B cell lymphoma;Follicular lymphoma Binary 19 unique SNPs MGI Michigan Genomics Initiative GWAS Hits GWAS Catalog (2019-05-03) 19620980;20639881;21533074;25261932;25279986 https://www.ncbi.nlm.nih.gov/pubmed/?term=19620980+20639881+21533074+25261932+25279986 12 0.54 0.00468697 0.0827 0.496 0.474-0.52 OR 1.08 0.474-2.44 1.08 0.474-2.44 1.14 0.643-2.02 1.14 0.643-2.02 1.08 0.739-1.57 1.08 0.739-1.57 1.12 0.852-1.47 1.12 0.852-1.47 1.05 0.867-1.28 1.05 0.867-1.28 1.07 0.839-1.35 0.605 0.944 0.739-1.21 0.647 1.06 0.837-1.35 0.612 FALSE FALSE FALSE FALSE Both 581 5803 GRCh37/hg19 P<=5e-08 2020-06-08 prsweb-phecode202-2-c83-pt-mgi-20200608 prsweb-phecode202-2-c83-pt-mgi-20200608 PRSWEB_PHECODE202.2_C83_PT_MGI_20200608 P&T PRSWEB_PHECODE202.2_C83_PT_MGI_20200608 202.2 Diagnoses - main ICD10: C83 Diffuse non-Hodgkin's lymphoma Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative P&T UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 134 0.2 0.00259074 0.0827 0.512 0.487-0.539 OR 1.09 0.482-2.48 1.09 0.482-2.48 1.15 0.65-2.04 1.15 0.65-2.04 1.42 1.01-1.99 1.42 1.01-1.99 1.22 0.938-1.59 1.22 0.938-1.59 1.24 1.02-1.49 1.24 1.02-1.49 0.798 0.621-1.03 0.0778 0.963 0.758-1.22 0.759 1.14 0.905-1.44 0.265 FALSE FALSE FALSE FALSE Both 581 5803 GRCh37/hg19 P<=6.31e-05 2020-06-08 prsweb-phecode202-2-c85-pt-mgi-20200608 prsweb-phecode202-2-c85-pt-mgi-20200608 PRSWEB_PHECODE202.2_C85_PT_MGI_20200608 P&T PRSWEB_PHECODE202.2_C85_PT_MGI_20200608 202.2 Diagnoses - main ICD10: C85 Other and unspecified types of non-Hodgkin's lymphoma Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative P&T UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 38 0.79 0.00619516 0.0827 0.492 0.469-0.516 OR 1.26 0.585-2.72 1.26 0.585-2.72 1.24 0.711-2.15 1.24 0.711-2.15 1.05 0.715-1.54 1.05 0.715-1.54 0.837 0.618-1.13 0.837 0.618-1.13 1.04 0.854-1.26 1.04 0.854-1.26 1.1 0.866-1.41 0.425 1.13 0.884-1.44 0.332 1.12 0.879-1.43 0.355 FALSE FALSE FALSE FALSE Both 581 5803 GRCh37/hg19 P<=1.58e-05 2020-06-08 prsweb-phecode202-2-gwas-catalog-r2019-05-03-x202-2-pt-mgi-20200608 prsweb-phecode202-2-gwas-catalog-r2019-05-03-x202-2-pt-mgi-20200608 PRSWEB_PHECODE202.2_GWAS-Catalog-r2019-05-03-X202.2_PT_MGI_20200608 P&T PRSWEB_PHECODE202.2_GWAS-Catalog-r2019-05-03-X202.2_PT_MGI_20200608 202.2 Diffuse large B cell lymphoma;Follicular lymphoma Binary 19 unique SNPs MGI Michigan Genomics Initiative P&T GWAS Catalog (2019-05-03) 19620980;20639881;21533074;25261932;25279986 https://www.ncbi.nlm.nih.gov/pubmed/?term=19620980+20639881+21533074+25261932+25279986 10 0.25 0.00741414 0.0827 0.505 0.483-0.528 OR 1.41 0.68-2.92 1.41 0.68-2.92 1.06 0.585-1.91 1.06 0.585-1.91 1.08 0.739-1.57 1.08 0.739-1.57 1.06 0.801-1.4 1.06 0.801-1.4 1.05 0.867-1.28 1.05 0.867-1.28 1.2 0.936-1.53 0.153 1.14 0.892-1.46 0.294 1.17 0.912-1.49 0.219 FALSE FALSE FALSE FALSE Both 581 5803 GRCh37/hg19 P<=1e-09 2020-06-08 prsweb-phecode202-2-c-nonhodgkin-nas-prs-cs-mgi-20200608 prsweb-phecode202-2-c-nonhodgkin-nas-prs-cs-mgi-20200608 PRSWEB_PHECODE202.2_C-NONHODGKIN-NAS_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE202.2_C-NONHODGKIN-NAS_PRS-CS_MGI_20200608 202.2 Other and unspecified types of non-Hodgkin lymphoma Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative PRS-CS UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1054742 0.44 2.17699e-06 0.0827 0.505 0.481-0.529 OR 1.95 1.02-3.7 1.95 1.02-3.7 1.6 0.97-2.64 1.6 0.97-2.64 1.16 0.803-1.68 1.16 0.803-1.68 1.2 0.921-1.57 1.2 0.921-1.57 0.985 0.808-1.2 0.985 0.808-1.2 1.01 0.797-1.29 0.911 1.04 0.817-1.32 0.757 0.995 0.781-1.27 0.968 FALSE FALSE FALSE FALSE Both 581 5803 GRCh37/hg19 auto 2020-06-08 prsweb-phecode202-2-c83-prs-cs-mgi-20200608 prsweb-phecode202-2-c83-prs-cs-mgi-20200608 PRSWEB_PHECODE202.2_C83_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE202.2_C83_PRS-CS_MGI_20200608 202.2 Diagnoses - main ICD10: C83 Diffuse non-Hodgkin's lymphoma Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative PRS-CS UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1087052 0.64 0.00258312 0.0827 0.508 0.484-0.533 OR 0.75 0.285-1.98 0.75 0.285-1.98 0.719 0.356-1.45 0.719 0.356-1.45 1.01 0.684-1.49 1.01 0.684-1.49 1.02 0.772-1.36 1.02 0.772-1.36 1.03 0.846-1.25 1.03 0.846-1.25 1.01 0.792-1.29 0.924 1.12 0.88-1.42 0.357 1.06 0.83-1.35 0.652 FALSE FALSE FALSE FALSE Both 581 5803 GRCh37/hg19 auto 2020-06-08 prsweb-phecode202-2-c-nonhodgkin-nas-lassosum-mgi-20200608 prsweb-phecode202-2-c-nonhodgkin-nas-lassosum-mgi-20200608 PRSWEB_PHECODE202.2_C-NONHODGKIN-NAS_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE202.2_C-NONHODGKIN-NAS_LASSOSUM_MGI_20200608 202.2 Other and unspecified types of non-Hodgkin lymphoma Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative lassosum UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1314 0.7 0.000418548 0.0827 0.451 0.431-0.474 OR 1.44 0.693-2.97 1.44 0.693-2.97 1.33 0.777-2.28 1.33 0.777-2.28 1.15 0.799-1.67 1.15 0.799-1.67 1.1 0.838-1.45 1.1 0.838-1.45 0.985 0.808-1.2 0.985 0.808-1.2 1.01 0.795-1.28 0.929 0.989 0.778-1.26 0.93 0.997 0.783-1.27 0.984 FALSE FALSE FALSE FALSE Both 581 5803 GRCh37/hg19 s=1;Lambda=0.1 2020-06-08 prsweb-phecode202-2-c83-lassosum-mgi-20200608 prsweb-phecode202-2-c83-lassosum-mgi-20200608 PRSWEB_PHECODE202.2_C83_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE202.2_C83_LASSOSUM_MGI_20200608 202.2 Diagnoses - main ICD10: C83 Diffuse non-Hodgkin's lymphoma Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative lassosum UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 363554 0.63 0.00444035 0.0827 0.502 0.476-0.528 OR 1.26 0.584-2.72 1.26 0.584-2.72 1.24 0.712-2.16 1.24 0.712-2.16 1.26 0.886-1.81 1.26 0.886-1.81 1.42 1.11-1.83 1.42 1.11-1.83 1.14 0.945-1.39 1.14 0.945-1.39 0.925 0.73-1.17 0.521 0.799 0.624-1.02 0.0746 1.02 0.811-1.29 0.846 FALSE FALSE FALSE FALSE Both 581 5803 GRCh37/hg19 s=1;Lambda=0.03793 2020-06-08 prsweb-phecode202-2-c85-lassosum-mgi-20200608 prsweb-phecode202-2-c85-lassosum-mgi-20200608 PRSWEB_PHECODE202.2_C85_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE202.2_C85_LASSOSUM_MGI_20200608 202.2 Diagnoses - main ICD10: C85 Other and unspecified types of non-Hodgkin's lymphoma Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative lassosum UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 48 0.71 0.0041736 0.0827 0.488 0.465-0.512 OR 0.753 0.286-1.98 0.753 0.286-1.98 0.804 0.412-1.57 0.804 0.412-1.57 1.24 0.864-1.78 1.24 0.864-1.78 0.972 0.729-1.3 0.972 0.729-1.3 1 0.823-1.22 1 0.823-1.22 1.08 0.849-1.38 0.528 1.09 0.852-1.38 0.506 1.04 0.817-1.33 0.74 FALSE FALSE FALSE FALSE Both 581 5803 GRCh37/hg19 s=0.2;Lambda=0.07848 2020-06-08 prsweb-phecode202-2-gwas-catalog-r2019-05-03-x202-2-p-5e-05-ukb-20200608 prsweb-phecode202-2-gwas-catalog-r2019-05-03-x202-2-p-5e-05-ukb-20200608 PRSWEB_PHECODE202.2_GWAS-Catalog-r2019-05-03-X202.2_P_5e-05_UKB_20200608 P_5e-05 PRSWEB_PHECODE202.2_GWAS-Catalog-r2019-05-03-X202.2_P_5e-05_UKB_20200608 202.2 Diffuse large B cell lymphoma;Follicular lymphoma Binary 19 unique SNPs UKB UK Biobank Fixed threshold (5e-05) GWAS Catalog (2019-05-03) 19620980;20639881;21533074;25261932;25279986 https://www.ncbi.nlm.nih.gov/pubmed/?term=19620980+20639881+21533074+25261932+25279986 18 6.4e-09 0.00659474 0.082 0.55 0.53-0.571 OR 2.28 1.4-3.7 2.28 1.4-3.7 1.76 1.2-2.59 1.76 1.2-2.59 1.58 1.22-2.06 1.58 1.22-2.06 1.57 1.29-1.91 1.57 1.29-1.91 1.35 1.17-1.57 1.35 1.17-1.57 1.14 0.927-1.41 0.21 1.38 1.13-1.69 0.00164 1.59 1.31-1.94 3.46e-06 TRUE FALSE FALSE FALSE Both 901 9051 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode202-2-gwas-catalog-r2019-05-03-x202-2-p-5e-06-ukb-20200608 prsweb-phecode202-2-gwas-catalog-r2019-05-03-x202-2-p-5e-06-ukb-20200608 PRSWEB_PHECODE202.2_GWAS-Catalog-r2019-05-03-X202.2_P_5e-06_UKB_20200608 P_5e-06 PRSWEB_PHECODE202.2_GWAS-Catalog-r2019-05-03-X202.2_P_5e-06_UKB_20200608 202.2 Diffuse large B cell lymphoma;Follicular lymphoma Binary 19 unique SNPs UKB UK Biobank Fixed threshold (5e-06) GWAS Catalog (2019-05-03) 19620980;20639881;21533074;25261932;25279986 https://www.ncbi.nlm.nih.gov/pubmed/?term=19620980+20639881+21533074+25261932+25279986 16 2.5e-07 0.00584255 0.0821 0.539 0.519-0.559 OR 1.6 0.913-2.8 1.6 0.913-2.8 1.93 1.33-2.8 1.93 1.33-2.8 1.73 1.34-2.23 1.73 1.34-2.23 1.49 1.22-1.82 1.49 1.22-1.82 1.28 1.11-1.49 1.28 1.11-1.49 1.2 0.98-1.48 0.0778 1.32 1.08-1.62 0.00678 1.51 1.24-1.83 4.66e-05 TRUE FALSE FALSE FALSE Both 901 9051 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode202-2-gwas-catalog-r2019-05-03-x202-2-p-5e-07-ukb-20200608 prsweb-phecode202-2-gwas-catalog-r2019-05-03-x202-2-p-5e-07-ukb-20200608 PRSWEB_PHECODE202.2_GWAS-Catalog-r2019-05-03-X202.2_P_5e-07_UKB_20200608 P_5e-07 PRSWEB_PHECODE202.2_GWAS-Catalog-r2019-05-03-X202.2_P_5e-07_UKB_20200608 202.2 Diffuse large B cell lymphoma;Follicular lymphoma Binary 19 unique SNPs UKB UK Biobank Fixed threshold (5e-07) GWAS Catalog (2019-05-03) 19620980;20639881;21533074;25261932;25279986 https://www.ncbi.nlm.nih.gov/pubmed/?term=19620980+20639881+21533074+25261932+25279986 16 2.5e-07 0.00584255 0.0821 0.539 0.519-0.559 OR 1.6 0.913-2.8 1.6 0.913-2.8 1.93 1.33-2.8 1.93 1.33-2.8 1.73 1.34-2.23 1.73 1.34-2.23 1.49 1.22-1.82 1.49 1.22-1.82 1.28 1.11-1.49 1.28 1.11-1.49 1.2 0.98-1.48 0.0778 1.32 1.08-1.62 0.00678 1.51 1.24-1.83 4.66e-05 TRUE FALSE FALSE FALSE Both 901 9051 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode202-2-gwas-catalog-r2019-05-03-x202-2-p-5e-09-ukb-20200608 prsweb-phecode202-2-gwas-catalog-r2019-05-03-x202-2-p-5e-09-ukb-20200608 PRSWEB_PHECODE202.2_GWAS-Catalog-r2019-05-03-X202.2_P_5e-09_UKB_20200608 P_5e-09 PRSWEB_PHECODE202.2_GWAS-Catalog-r2019-05-03-X202.2_P_5e-09_UKB_20200608 202.2 Diffuse large B cell lymphoma;Follicular lymphoma Binary 19 unique SNPs UKB UK Biobank Fixed threshold (5e-09) GWAS Catalog (2019-05-03) 19620980;20639881;21533074;25261932;25279986 https://www.ncbi.nlm.nih.gov/pubmed/?term=19620980+20639881+21533074+25261932+25279986 11 2.9e-08 0.0058778 0.0821 0.54 0.52-0.56 OR 1.6 0.914-2.8 1.6 0.914-2.8 1.92 1.33-2.79 1.92 1.33-2.79 1.83 1.43-2.34 1.83 1.43-2.34 1.6 1.32-1.95 1.6 1.32-1.95 1.35 1.17-1.57 1.35 1.17-1.57 1.05 0.853-1.29 0.656 1.21 0.995-1.48 0.0563 1.48 1.22-1.79 7.11e-05 TRUE FALSE FALSE FALSE Both 901 9051 GRCh37/hg19 P<=5e-09 2020-06-08 prsweb-phecode202-2-gwas-catalog-r2019-05-03-x202-2-p-5e-08-ukb-20200608 prsweb-phecode202-2-gwas-catalog-r2019-05-03-x202-2-p-5e-08-ukb-20200608 PRSWEB_PHECODE202.2_GWAS-Catalog-r2019-05-03-X202.2_P_5e-08_UKB_20200608 P_5e-08 PRSWEB_PHECODE202.2_GWAS-Catalog-r2019-05-03-X202.2_P_5e-08_UKB_20200608 202.2 Diffuse large B cell lymphoma;Follicular lymphoma Binary 19 unique SNPs UKB UK Biobank GWAS Hits GWAS Catalog (2019-05-03) 19620980;20639881;21533074;25261932;25279986 https://www.ncbi.nlm.nih.gov/pubmed/?term=19620980+20639881+21533074+25261932+25279986 12 1.9e-08 0.00556011 0.0821 0.541 0.521-0.561 OR 2.05 1.24-3.4 2.05 1.24-3.4 2.11 1.47-3.02 2.11 1.47-3.02 1.83 1.43-2.35 1.83 1.43-2.35 1.56 1.28-1.9 1.56 1.28-1.9 1.27 1.09-1.48 1.27 1.09-1.48 1.23 1-1.51 0.0478 1.3 1.07-1.6 0.0101 1.5 1.23-1.82 6.08e-05 TRUE FALSE FALSE TRUE Both 901 9051 GRCh37/hg19 P<=5e-08 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000641/ScoringFiles/ phewas/PRSWEB_PHECODE202.2_GWAS-Catalog-r2019-05-03-X202.2_P_5e-08_UKB_20200608/all.tsv phewas/PRSWEB_PHECODE202.2_GWAS-Catalog-r2019-05-03-X202.2_P_5e-08_UKB_20200608/exclusion.tsv 2020-06-08 prsweb-phecode202-2-gwas-catalog-r2019-05-03-x202-2-pt-ukb-20200608 prsweb-phecode202-2-gwas-catalog-r2019-05-03-x202-2-pt-ukb-20200608 PRSWEB_PHECODE202.2_GWAS-Catalog-r2019-05-03-X202.2_PT_UKB_20200608 P&T PRSWEB_PHECODE202.2_GWAS-Catalog-r2019-05-03-X202.2_PT_UKB_20200608 202.2 Diffuse large B cell lymphoma;Follicular lymphoma Binary 19 unique SNPs UKB UK Biobank P&T GWAS Catalog (2019-05-03) 19620980;20639881;21533074;25261932;25279986 https://www.ncbi.nlm.nih.gov/pubmed/?term=19620980+20639881+21533074+25261932+25279986 10 2e-10 0.00816398 0.082 0.547 0.527-0.566 OR 2.05 1.24-3.4 2.05 1.24-3.4 1.9 1.31-2.75 1.9 1.31-2.75 2.05 1.62-2.61 2.05 1.62-2.61 1.65 1.36-2 1.65 1.36-2 1.51 1.31-1.75 1.51 1.31-1.75 0.93 0.753-1.15 0.501 1.19 0.977-1.46 0.0826 1.58 1.31-1.91 2.22e-06 TRUE FALSE FALSE TRUE Both 901 9051 GRCh37/hg19 P<=1e-09 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000642/ScoringFiles/ phewas/PRSWEB_PHECODE202.2_GWAS-Catalog-r2019-05-03-X202.2_PT_UKB_20200608/all.tsv phewas/PRSWEB_PHECODE202.2_GWAS-Catalog-r2019-05-03-X202.2_PT_UKB_20200608/exclusion.tsv 2020-06-08 prsweb-phecode202-21-c-follicular-lymphoma-p-5e-05-mgi-20200608 prsweb-phecode202-21-c-follicular-lymphoma-p-5e-05-mgi-20200608 PRSWEB_PHECODE202.21_C-FOLLICULAR-LYMPHOMA_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE202.21_C-FOLLICULAR-LYMPHOMA_P_5e-05_MGI_20200608 202.21 Follicular lymphoma Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 103 0.39 9.89205e-05 0.0826 0.502 0.47-0.535 OR 2.16 0.908-5.13 2.16 0.908-5.13 1.41 0.68-2.93 1.41 0.68-2.93 0.976 0.561-1.7 0.976 0.561-1.7 1.15 0.785-1.67 1.15 0.785-1.67 1.1 0.837-1.43 1.1 0.837-1.43 1.07 0.758-1.51 0.703 1.15 0.815-1.61 0.432 1.17 0.834-1.64 0.365 FALSE FALSE FALSE FALSE Both 296 2960 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode202-21-c82-p-5e-05-mgi-20200608 prsweb-phecode202-21-c82-p-5e-05-mgi-20200608 PRSWEB_PHECODE202.21_C82_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE202.21_C82_P_5e-05_MGI_20200608 202.21 Diagnoses - main ICD10: C82 Follicular [nodular] non-Hodgkin's lymphoma Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 91 0.085 0.00016326 0.0826 0.518 0.486-0.553 OR 1.47 0.537-4.04 1.47 0.537-4.04 1.24 0.574-2.68 1.24 0.574-2.68 0.972 0.559-1.69 0.972 0.559-1.69 1.18 0.813-1.72 1.18 0.813-1.72 1.19 0.916-1.56 1.19 0.916-1.56 0.899 0.625-1.29 0.565 1.31 0.937-1.83 0.115 1.3 0.926-1.82 0.131 FALSE FALSE FALSE FALSE Both 296 2960 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode202-21-ukbb-saige-hrc-x202-21-p-5e-05-mgi-20200608 prsweb-phecode202-21-ukbb-saige-hrc-x202-21-p-5e-05-mgi-20200608 PRSWEB_PHECODE202.21_UKBB-SAIGE-HRC-X202.21_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE202.21_UKBB-SAIGE-HRC-X202.21_P_5e-05_MGI_20200608 202.21 Nodular lymphoma Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 116 0.055 0.000672577 0.0826 0.52 0.488-0.55 OR 1.14 0.371-3.53 1.14 0.371-3.53 0.738 0.28-1.95 0.738 0.28-1.95 0.978 0.562-1.7 0.978 0.562-1.7 1.07 0.727-1.58 1.07 0.727-1.58 1.04 0.794-1.37 1.04 0.794-1.37 1.04 0.715-1.51 0.836 1.85 1.32-2.59 0.000383 1.38 0.967-1.98 0.0757 FALSE FALSE FALSE FALSE Both 296 2960 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode202-21-c-follicular-lymphoma-p-5e-06-mgi-20200608 prsweb-phecode202-21-c-follicular-lymphoma-p-5e-06-mgi-20200608 PRSWEB_PHECODE202.21_C-FOLLICULAR-LYMPHOMA_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE202.21_C-FOLLICULAR-LYMPHOMA_P_5e-06_MGI_20200608 202.21 Follicular lymphoma Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 26 0.036 0.000162445 0.0825 0.506 0.474-0.54 OR 1.82 0.72-4.61 1.82 0.72-4.61 1.41 0.678-2.93 1.41 0.678-2.93 1.48 0.926-2.37 1.48 0.926-2.37 1.34 0.936-1.92 1.34 0.936-1.92 1.27 0.98-1.65 1.27 0.98-1.65 0.869 0.611-1.24 0.438 1.05 0.75-1.47 0.775 1.25 0.905-1.74 0.174 TRUE FALSE FALSE FALSE Both 296 2960 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode202-21-c82-p-5e-06-mgi-20200608 prsweb-phecode202-21-c82-p-5e-06-mgi-20200608 PRSWEB_PHECODE202.21_C82_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE202.21_C82_P_5e-06_MGI_20200608 202.21 Diagnoses - main ICD10: C82 Follicular [nodular] non-Hodgkin's lymphoma Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 17 0.32 0.00013419 0.0826 0.484 0.453-0.516 OR 0.816 0.22-3.02 0.816 0.22-3.02 1.07 0.471-2.43 1.07 0.471-2.43 1.12 0.664-1.89 1.12 0.664-1.89 1.3 0.907-1.87 1.3 0.907-1.87 1.13 0.868-1.48 1.13 0.868-1.48 0.914 0.648-1.29 0.608 0.992 0.71-1.39 0.962 1.11 0.797-1.54 0.543 FALSE FALSE FALSE FALSE Both 296 2960 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode202-21-ukbb-saige-hrc-x202-21-p-5e-06-mgi-20200608 prsweb-phecode202-21-ukbb-saige-hrc-x202-21-p-5e-06-mgi-20200608 PRSWEB_PHECODE202.21_UKBB-SAIGE-HRC-X202.21_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE202.21_UKBB-SAIGE-HRC-X202.21_P_5e-06_MGI_20200608 202.21 Nodular lymphoma Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 24 0.19 0.000658985 0.0826 0.492 0.459-0.524 OR 1.15 0.374-3.56 1.15 0.374-3.56 1.08 0.473-2.45 1.08 0.473-2.45 1.12 0.663-1.89 1.12 0.663-1.89 1.3 0.908-1.87 1.3 0.908-1.87 1.21 0.931-1.58 1.21 0.931-1.58 1.38 0.968-1.96 0.0755 1.3 0.911-1.86 0.148 1.5 1.06-2.12 0.0227 FALSE FALSE FALSE FALSE Both 296 2960 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode202-21-c-follicular-lymphoma-p-5e-07-mgi-20200608 prsweb-phecode202-21-c-follicular-lymphoma-p-5e-07-mgi-20200608 PRSWEB_PHECODE202.21_C-FOLLICULAR-LYMPHOMA_P_5e-07_MGI_20200608 P_5e-07 PRSWEB_PHECODE202.21_C-FOLLICULAR-LYMPHOMA_P_5e-07_MGI_20200608 202.21 Follicular lymphoma Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-07) UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 10 0.056 0.000332802 0.0825 0.493 0.462-0.526 OR 1.48 0.54-4.06 1.48 0.54-4.06 1.76 0.903-3.45 1.76 0.903-3.45 1.48 0.928-2.37 1.48 0.928-2.37 1.19 0.816-1.72 1.19 0.816-1.72 1.17 0.9-1.53 1.17 0.9-1.53 1.05 0.736-1.49 0.804 1.22 0.867-1.71 0.254 1.28 0.916-1.8 0.146 FALSE FALSE FALSE FALSE Both 296 2960 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode202-21-c82-p-5e-07-mgi-20200608 prsweb-phecode202-21-c82-p-5e-07-mgi-20200608 PRSWEB_PHECODE202.21_C82_P_5e-07_MGI_20200608 P_5e-07 PRSWEB_PHECODE202.21_C82_P_5e-07_MGI_20200608 202.21 Diagnoses - main ICD10: C82 Follicular [nodular] non-Hodgkin's lymphoma Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-07) UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 10 0.18 9.79752e-05 0.0826 0.479 0.447-0.511 OR 1.14 0.371-3.53 1.14 0.371-3.53 1.58 0.786-3.18 1.58 0.786-3.18 1.12 0.663-1.89 1.12 0.663-1.89 1.27 0.877-1.83 1.27 0.877-1.83 1.17 0.9-1.53 1.17 0.9-1.53 1.03 0.733-1.46 0.848 1.03 0.732-1.45 0.858 1.21 0.865-1.69 0.268 FALSE FALSE FALSE FALSE Both 296 2960 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode202-21-ukbb-saige-hrc-x202-21-p-5e-07-mgi-20200608 prsweb-phecode202-21-ukbb-saige-hrc-x202-21-p-5e-07-mgi-20200608 PRSWEB_PHECODE202.21_UKBB-SAIGE-HRC-X202.21_P_5e-07_MGI_20200608 P_5e-07 PRSWEB_PHECODE202.21_UKBB-SAIGE-HRC-X202.21_P_5e-07_MGI_20200608 202.21 Nodular lymphoma Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative Fixed threshold (5e-07) UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 10 0.25 0.000596648 0.0826 0.478 0.446-0.51 OR 1.81 0.715-4.57 1.81 0.715-4.57 1.24 0.573-2.68 1.24 0.573-2.68 1.19 0.717-1.99 1.19 0.717-1.99 0.962 0.642-1.44 0.962 0.642-1.44 1.23 0.949-1.61 1.23 0.949-1.61 0.991 0.703-1.4 0.959 0.986 0.699-1.39 0.937 1.25 0.899-1.74 0.185 FALSE FALSE FALSE FALSE Both 296 2960 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode202-21-c-follicular-lymphoma-p-5e-09-mgi-20200608 prsweb-phecode202-21-c-follicular-lymphoma-p-5e-09-mgi-20200608 PRSWEB_PHECODE202.21_C-FOLLICULAR-LYMPHOMA_P_5e-09_MGI_20200608 P_5e-09 PRSWEB_PHECODE202.21_C-FOLLICULAR-LYMPHOMA_P_5e-09_MGI_20200608 202.21 Follicular lymphoma Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-09) UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 5 0.097 0.000105966 0.0826 0.474 0.442-0.506 OR 1.81 0.716-4.58 1.81 0.716-4.58 1.58 0.787-3.18 1.58 0.787-3.18 1.56 0.985-2.48 1.56 0.985-2.48 1.23 0.849-1.78 1.23 0.849-1.78 1.17 0.9-1.53 1.17 0.9-1.53 1.38 0.963-1.97 0.0794 1.45 1.02-2.06 0.0401 1.52 1.07-2.16 0.0206 FALSE FALSE FALSE FALSE Both 296 2960 GRCh37/hg19 P<=5e-09 2020-06-08 prsweb-phecode202-21-c82-p-5e-09-mgi-20200608 prsweb-phecode202-21-c82-p-5e-09-mgi-20200608 PRSWEB_PHECODE202.21_C82_P_5e-09_MGI_20200608 P_5e-09 PRSWEB_PHECODE202.21_C82_P_5e-09_MGI_20200608 202.21 Diagnoses - main ICD10: C82 Follicular [nodular] non-Hodgkin's lymphoma Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-09) UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 6 0.14 0.000186128 0.0826 0.477 0.447-0.509 OR 1.81 0.715-4.56 1.81 0.715-4.56 1.41 0.678-2.93 1.41 0.678-2.93 0.767 0.416-1.41 0.767 0.416-1.41 1.03 0.698-1.53 1.03 0.698-1.53 1.21 0.933-1.58 1.21 0.933-1.58 1.51 1.02-2.24 0.0402 1.36 0.916-2.03 0.127 1.58 1.07-2.33 0.0224 FALSE FALSE FALSE FALSE Both 296 2960 GRCh37/hg19 P<=5e-09 2020-06-08 prsweb-phecode202-21-ukbb-saige-hrc-x202-21-p-5e-09-mgi-20200608 prsweb-phecode202-21-ukbb-saige-hrc-x202-21-p-5e-09-mgi-20200608 PRSWEB_PHECODE202.21_UKBB-SAIGE-HRC-X202.21_P_5e-09_MGI_20200608 P_5e-09 PRSWEB_PHECODE202.21_UKBB-SAIGE-HRC-X202.21_P_5e-09_MGI_20200608 202.21 Nodular lymphoma Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative Fixed threshold (5e-09) UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 7 0.14 0.0002615 0.0826 0.475 0.443-0.509 OR 1.48 0.539-4.05 1.48 0.539-4.05 1.75 0.898-3.43 1.75 0.898-3.43 1.27 0.77-2.09 1.27 0.77-2.09 1.27 0.881-1.83 1.27 0.881-1.83 1.12 0.853-1.46 1.12 0.853-1.46 0.856 0.605-1.21 0.378 1.05 0.756-1.47 0.759 1.1 0.792-1.53 0.565 FALSE FALSE FALSE FALSE Both 296 2960 GRCh37/hg19 P<=5e-09 2020-06-08 prsweb-phecode202-21-c-follicular-lymphoma-p-5e-08-mgi-20200608 prsweb-phecode202-21-c-follicular-lymphoma-p-5e-08-mgi-20200608 PRSWEB_PHECODE202.21_C-FOLLICULAR-LYMPHOMA_P_5e-08_MGI_20200608 P_5e-08 PRSWEB_PHECODE202.21_C-FOLLICULAR-LYMPHOMA_P_5e-08_MGI_20200608 202.21 Follicular lymphoma Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative GWAS Hits UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 6 0.13 0.000195783 0.0826 0.476 0.444-0.508 OR 1.82 0.719-4.59 1.82 0.719-4.59 1.41 0.68-2.94 1.41 0.68-2.94 1.2 0.717-1.99 1.2 0.717-1.99 1.15 0.787-1.68 1.15 0.787-1.68 1.12 0.853-1.46 1.12 0.853-1.46 1.38 0.971-1.96 0.0722 1.37 0.962-1.95 0.0813 1.42 0.997-2.02 0.0522 FALSE FALSE FALSE FALSE Both 296 2960 GRCh37/hg19 P<=5e-08 2020-06-08 prsweb-phecode202-21-c82-p-5e-08-mgi-20200608 prsweb-phecode202-21-c82-p-5e-08-mgi-20200608 PRSWEB_PHECODE202.21_C82_P_5e-08_MGI_20200608 P_5e-08 PRSWEB_PHECODE202.21_C82_P_5e-08_MGI_20200608 202.21 Diagnoses - main ICD10: C82 Follicular [nodular] non-Hodgkin's lymphoma Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative GWAS Hits UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 6 0.14 0.000186128 0.0826 0.477 0.447-0.509 OR 1.81 0.715-4.56 1.81 0.715-4.56 1.41 0.678-2.93 1.41 0.678-2.93 0.767 0.416-1.41 0.767 0.416-1.41 1.03 0.698-1.53 1.03 0.698-1.53 1.21 0.933-1.58 1.21 0.933-1.58 1.51 1.02-2.24 0.0402 1.36 0.916-2.03 0.127 1.58 1.07-2.33 0.0224 FALSE FALSE FALSE FALSE Both 296 2960 GRCh37/hg19 P<=5e-08 2020-06-08 prsweb-phecode202-21-ukbb-saige-hrc-x202-21-p-5e-08-mgi-20200608 prsweb-phecode202-21-ukbb-saige-hrc-x202-21-p-5e-08-mgi-20200608 PRSWEB_PHECODE202.21_UKBB-SAIGE-HRC-X202.21_P_5e-08_MGI_20200608 P_5e-08 PRSWEB_PHECODE202.21_UKBB-SAIGE-HRC-X202.21_P_5e-08_MGI_20200608 202.21 Nodular lymphoma Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative GWAS Hits UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 8 0.24 0.000426049 0.0826 0.474 0.442-0.506 OR 1.81 0.715-4.57 1.81 0.715-4.57 1.41 0.679-2.93 1.41 0.679-2.93 1.12 0.664-1.89 1.12 0.664-1.89 0.962 0.642-1.44 0.962 0.642-1.44 1.21 0.931-1.58 1.21 0.931-1.58 0.938 0.665-1.32 0.713 0.972 0.69-1.37 0.872 1.21 0.869-1.68 0.261 FALSE FALSE FALSE FALSE Both 296 2960 GRCh37/hg19 P<=5e-08 2020-06-08 prsweb-phecode202-21-c-follicular-lymphoma-pt-mgi-20200608 prsweb-phecode202-21-c-follicular-lymphoma-pt-mgi-20200608 PRSWEB_PHECODE202.21_C-FOLLICULAR-LYMPHOMA_PT_MGI_20200608 P&T PRSWEB_PHECODE202.21_C-FOLLICULAR-LYMPHOMA_PT_MGI_20200608 202.21 Follicular lymphoma Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative P&T UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 169 0.82 0.00073104 0.0826 0.491 0.458-0.525 OR 2.15 0.906-5.11 2.15 0.906-5.11 1.92 1.01-3.67 1.92 1.01-3.67 1.33 0.818-2.17 1.33 0.818-2.17 1.07 0.725-1.58 1.07 0.725-1.58 0.968 0.734-1.28 0.968 0.734-1.28 1.17 0.846-1.63 0.336 0.936 0.663-1.32 0.707 1 0.715-1.41 0.981 FALSE FALSE FALSE FALSE Both 296 2960 GRCh37/hg19 P<=9.98e-05 2020-06-08 prsweb-phecode202-21-c82-pt-mgi-20200608 prsweb-phecode202-21-c82-pt-mgi-20200608 PRSWEB_PHECODE202.21_C82_PT_MGI_20200608 P&T PRSWEB_PHECODE202.21_C82_PT_MGI_20200608 202.21 Diagnoses - main ICD10: C82 Follicular [nodular] non-Hodgkin's lymphoma Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative P&T UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 5 0.28 0.00042835 0.0826 0.467 0.436-0.501 OR 1.8 0.712-4.55 1.8 0.712-4.55 1.24 0.574-2.68 1.24 0.574-2.68 0.964 0.555-1.68 0.964 0.555-1.68 1.07 0.728-1.58 1.07 0.728-1.58 1.13 0.862-1.47 1.13 0.862-1.47 1.03 0.642-1.66 0.892 0.87 0.537-1.41 0.569 1.06 0.661-1.7 0.806 FALSE FALSE FALSE FALSE Both 296 2960 GRCh37/hg19 P<=3.98e-10 2020-06-08 prsweb-phecode202-21-ukbb-saige-hrc-x202-21-pt-mgi-20200608 prsweb-phecode202-21-ukbb-saige-hrc-x202-21-pt-mgi-20200608 PRSWEB_PHECODE202.21_UKBB-SAIGE-HRC-X202.21_PT_MGI_20200608 P&T PRSWEB_PHECODE202.21_UKBB-SAIGE-HRC-X202.21_PT_MGI_20200608 202.21 Nodular lymphoma Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative P&T UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 207 0.12 0.00184003 0.0826 0.518 0.483-0.55 OR 0.814 0.22-3.02 0.814 0.22-3.02 0.74 0.281-1.95 0.74 0.281-1.95 0.976 0.562-1.7 0.976 0.562-1.7 0.884 0.583-1.34 0.884 0.583-1.34 1.11 0.852-1.46 1.11 0.852-1.46 1.05 0.733-1.52 0.776 1.54 1.09-2.16 0.0133 1.36 0.961-1.93 0.0821 FALSE FALSE FALSE FALSE Both 296 2960 GRCh37/hg19 P<=9.98e-05 2020-06-08 prsweb-phecode202-21-c-follicular-lymphoma-prs-cs-mgi-20200608 prsweb-phecode202-21-c-follicular-lymphoma-prs-cs-mgi-20200608 PRSWEB_PHECODE202.21_C-FOLLICULAR-LYMPHOMA_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE202.21_C-FOLLICULAR-LYMPHOMA_PRS-CS_MGI_20200608 202.21 Follicular lymphoma Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative PRS-CS UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1048780 0.041 6.12604e-06 0.0825 0.532 0.497-0.568 OR 2.49 1.1-5.65 2.49 1.1-5.65 1.93 1.01-3.68 1.93 1.01-3.68 0.972 0.559-1.69 0.972 0.559-1.69 1.38 0.966-1.97 1.38 0.966-1.97 1.31 1.01-1.7 1.31 1.01-1.7 1.1 0.777-1.55 0.599 0.997 0.701-1.42 0.989 1.36 0.977-1.9 0.068 TRUE FALSE FALSE TRUE Both 296 2960 GRCh37/hg19 auto https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000643/ScoringFiles/ phewas/PRSWEB_PHECODE202.21_C-FOLLICULAR-LYMPHOMA_PRS-CS_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE202.21_C-FOLLICULAR-LYMPHOMA_PRS-CS_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode202-21-c82-prs-cs-mgi-20200608 prsweb-phecode202-21-c82-prs-cs-mgi-20200608 PRSWEB_PHECODE202.21_C82_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE202.21_C82_PRS-CS_MGI_20200608 202.21 Diagnoses - main ICD10: C82 Follicular [nodular] non-Hodgkin's lymphoma Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative PRS-CS UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1047514 0.89 2.45655e-05 0.0826 0.502 0.467-0.536 OR 0.814 0.219-3.02 0.814 0.219-3.02 0.9 0.371-2.18 0.9 0.371-2.18 0.969 0.558-1.69 0.969 0.558-1.69 1.03 0.694-1.52 1.03 0.694-1.52 1 0.762-1.32 1 0.762-1.32 1.01 0.716-1.41 0.977 1.04 0.746-1.46 0.804 1.04 0.744-1.46 0.808 FALSE FALSE FALSE FALSE Both 296 2960 GRCh37/hg19 auto 2020-06-08 prsweb-phecode202-21-ukbb-saige-hrc-x202-21-prs-cs-mgi-20200608 prsweb-phecode202-21-ukbb-saige-hrc-x202-21-prs-cs-mgi-20200608 PRSWEB_PHECODE202.21_UKBB-SAIGE-HRC-X202.21_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE202.21_UKBB-SAIGE-HRC-X202.21_PRS-CS_MGI_20200608 202.21 Nodular lymphoma Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative PRS-CS UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1119238 0.5 1.06733e-09 0.0826 0.508 0.473-0.542 OR 0.485 0.092-2.56 0.485 0.092-2.56 1.24 0.572-2.68 1.24 0.572-2.68 1.04 0.606-1.77 1.04 0.606-1.77 1.21 0.838-1.76 1.21 0.838-1.76 1.29 0.993-1.67 1.29 0.993-1.67 0.995 0.716-1.38 0.979 0.671 0.465-0.967 0.0325 1.16 0.839-1.59 0.374 FALSE FALSE FALSE FALSE Both 296 2960 GRCh37/hg19 auto 2020-06-08 prsweb-phecode202-21-c-follicular-lymphoma-lassosum-mgi-20200608 prsweb-phecode202-21-c-follicular-lymphoma-lassosum-mgi-20200608 PRSWEB_PHECODE202.21_C-FOLLICULAR-LYMPHOMA_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE202.21_C-FOLLICULAR-LYMPHOMA_LASSOSUM_MGI_20200608 202.21 Follicular lymphoma Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative lassosum UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 2209179 0.022 0.00142981 0.0825 0.538 0.504-0.573 OR 1.48 0.538-4.05 1.48 0.538-4.05 1.42 0.682-2.94 1.42 0.682-2.94 1.04 0.609-1.79 1.04 0.609-1.79 1.3 0.905-1.87 1.3 0.905-1.87 1.38 1.07-1.79 1.38 1.07-1.79 1.37 0.968-1.95 0.0755 1.12 0.78-1.62 0.535 1.57 1.12-2.21 0.00936 TRUE FALSE FALSE TRUE Both 296 2960 GRCh37/hg19 s=1;Lambda=0.01833 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000644/ScoringFiles/ phewas/PRSWEB_PHECODE202.21_C-FOLLICULAR-LYMPHOMA_LASSOSUM_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE202.21_C-FOLLICULAR-LYMPHOMA_LASSOSUM_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode202-21-c82-lassosum-mgi-20200608 prsweb-phecode202-21-c82-lassosum-mgi-20200608 PRSWEB_PHECODE202.21_C82_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE202.21_C82_LASSOSUM_MGI_20200608 202.21 Diagnoses - main ICD10: C82 Follicular [nodular] non-Hodgkin's lymphoma Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative lassosum UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 137530 0.074 0.00032768 0.0826 0.506 0.473-0.539 OR 1.82 0.722-4.61 1.82 0.722-4.61 1.25 0.577-2.7 1.25 0.577-2.7 0.98 0.564-1.7 0.98 0.564-1.7 1.15 0.787-1.68 1.15 0.787-1.68 1.34 1.03-1.74 1.34 1.03-1.74 0.985 0.694-1.4 0.933 1.03 0.731-1.46 0.847 1.36 0.98-1.89 0.066 FALSE FALSE FALSE FALSE Both 296 2960 GRCh37/hg19 s=1;Lambda=0.06158 2020-06-08 prsweb-phecode202-21-ukbb-saige-hrc-x202-21-lassosum-mgi-20200608 prsweb-phecode202-21-ukbb-saige-hrc-x202-21-lassosum-mgi-20200608 PRSWEB_PHECODE202.21_UKBB-SAIGE-HRC-X202.21_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE202.21_UKBB-SAIGE-HRC-X202.21_LASSOSUM_MGI_20200608 202.21 Nodular lymphoma Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative lassosum UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 6090866 0.73 0.000854137 0.0826 0.502 0.468-0.536 OR 0.819 0.221-3.04 0.819 0.221-3.04 0.909 0.375-2.2 0.909 0.375-2.2 1.41 0.875-2.28 1.41 0.875-2.28 1.3 0.906-1.87 1.3 0.906-1.87 1.04 0.792-1.36 1.04 0.792-1.36 1 0.717-1.4 0.999 0.918 0.653-1.29 0.621 1.01 0.722-1.4 0.967 FALSE FALSE FALSE FALSE Both 296 2960 GRCh37/hg19 s=1;Lambda=0.001 2020-06-08 prsweb-phecode202-24-ukbb-saige-hrc-x202-24-p-5e-06-mgi-20200608 prsweb-phecode202-24-ukbb-saige-hrc-x202-24-p-5e-06-mgi-20200608 PRSWEB_PHECODE202.24_UKBB-SAIGE-HRC-X202.24_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE202.24_UKBB-SAIGE-HRC-X202.24_P_5e-06_MGI_20200608 202.24 Large cell lymphoma Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 11 0.64 0.0183925 0.0832 0.505 0.442-0.572 OR 1.98 0.307-12.8 1.98 0.307-12.8 1.71 0.423-6.9 1.71 0.423-6.9 1.02 0.33-3.17 1.02 0.33-3.17 0.64 0.24-1.71 0.64 0.24-1.71 0.903 0.5-1.63 0.903 0.5-1.63 2.01 0.974-4.15 0.0589 1.46 0.68-3.13 0.332 1.31 0.601-2.84 0.5 FALSE FALSE FALSE FALSE Both 66 655 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode202-24-ukbb-saige-hrc-x202-24-pt-mgi-20200608 prsweb-phecode202-24-ukbb-saige-hrc-x202-24-pt-mgi-20200608 PRSWEB_PHECODE202.24_UKBB-SAIGE-HRC-X202.24_PT_MGI_20200608 P&T PRSWEB_PHECODE202.24_UKBB-SAIGE-HRC-X202.24_PT_MGI_20200608 202.24 Large cell lymphoma Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative P&T UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 7 0.11 0.0328413 0.0829 0.548 0.485-0.616 OR 2 0.305-13.1 2 0.305-13.1 2.46 0.719-8.45 2.46 0.719-8.45 1.35 0.484-3.78 1.35 0.484-3.78 1.47 0.707-3.05 1.47 0.707-3.05 1.23 0.712-2.14 1.23 0.712-2.14 1.58 0.706-3.54 0.266 1.98 0.928-4.21 0.0773 2.1 0.968-4.58 0.0603 FALSE FALSE FALSE FALSE Both 66 655 GRCh37/hg19 P<=2.51e-06 2020-06-08 prsweb-phecode204-ukbb-saige-hrc-x204-p-5e-05-mgi-20200608 prsweb-phecode204-ukbb-saige-hrc-x204-p-5e-05-mgi-20200608 PRSWEB_PHECODE204_UKBB-SAIGE-HRC-X204_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE204_UKBB-SAIGE-HRC-X204_P_5e-05_MGI_20200608 204 Leukemia Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 129 0.096 0.00066718 0.0825 0.528 0.492-0.566 OR 1.23 0.397-3.82 1.23 0.397-3.82 1.32 0.608-2.87 1.32 0.608-2.87 1.19 0.705-2.02 1.19 0.705-2.02 1.27 0.873-1.86 1.27 0.873-1.86 1.22 0.929-1.6 1.22 0.929-1.6 0.917 0.635-1.32 0.644 1.16 0.817-1.64 0.412 1.26 0.892-1.77 0.19 FALSE FALSE FALSE FALSE Both 277 2770 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode204-ukbb-saige-hrc-x204-p-5e-06-mgi-20200608 prsweb-phecode204-ukbb-saige-hrc-x204-p-5e-06-mgi-20200608 PRSWEB_PHECODE204_UKBB-SAIGE-HRC-X204_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE204_UKBB-SAIGE-HRC-X204_P_5e-06_MGI_20200608 204 Leukemia Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 14 0.67 0.000712274 0.0826 0.503 0.47-0.538 OR 0.531 0.1-2.81 0.531 0.1-2.81 0.441 0.123-1.58 0.441 0.123-1.58 0.596 0.295-1.2 0.596 0.295-1.2 0.991 0.656-1.5 0.991 0.656-1.5 0.948 0.711-1.26 0.948 0.711-1.26 1.29 0.897-1.86 0.169 1.53 1.08-2.18 0.017 1.21 0.831-1.75 0.324 FALSE FALSE FALSE FALSE Both 277 2770 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode204-ukbb-saige-hrc-x204-pt-mgi-20200608 prsweb-phecode204-ukbb-saige-hrc-x204-pt-mgi-20200608 PRSWEB_PHECODE204_UKBB-SAIGE-HRC-X204_PT_MGI_20200608 P&T PRSWEB_PHECODE204_UKBB-SAIGE-HRC-X204_PT_MGI_20200608 204 Leukemia Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative P&T UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 11 0.23 0.00160209 0.0826 0.515 0.483-0.549 OR 0 0-0 0 0-0 0.261 0.051-1.33 0.261 0.051-1.33 1.04 0.598-1.82 1.04 0.598-1.82 0.997 0.66-1.51 0.997 0.66-1.51 1.12 0.852-1.48 1.12 0.852-1.48 1.11 0.777-1.6 0.556 1.25 0.881-1.78 0.211 1.24 0.873-1.77 0.227 FALSE FALSE FALSE FALSE Both 277 2770 GRCh37/hg19 P<=3.16e-06 2020-06-08 prsweb-phecode204-20001-1048-prs-cs-mgi-20200608 prsweb-phecode204-20001-1048-prs-cs-mgi-20200608 PRSWEB_PHECODE204_20001-1048_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE204_20001-1048_PRS-CS_MGI_20200608 204 Cancer code, self-reported: leukaemia Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative PRS-CS UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 943472 0.9 0.00145612 0.0826 0.501 0.467-0.537 OR 0.876 0.235-3.26 0.876 0.235-3.26 2.07 1.08-3.97 2.07 1.08-3.97 1.19 0.704-2.01 1.19 0.704-2.01 1.11 0.745-1.64 1.11 0.745-1.64 1.02 0.766-1.35 1.02 0.766-1.35 1.2 0.85-1.69 0.3 0.999 0.699-1.43 0.997 1.08 0.762-1.54 0.66 FALSE FALSE FALSE FALSE Both 277 2770 GRCh37/hg19 auto 2020-06-08 prsweb-phecode204-ukbb-saige-hrc-x204-prs-cs-mgi-20200608 prsweb-phecode204-ukbb-saige-hrc-x204-prs-cs-mgi-20200608 PRSWEB_PHECODE204_UKBB-SAIGE-HRC-X204_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE204_UKBB-SAIGE-HRC-X204_PRS-CS_MGI_20200608 204 Leukemia Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative PRS-CS UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1119238 0.068 0.00123352 0.0825 0.532 0.494-0.567 OR 2.02 0.793-5.15 2.02 0.793-5.15 1.75 0.864-3.53 1.75 0.864-3.53 1.9 1.22-2.96 1.9 1.22-2.96 1.85 1.32-2.59 1.85 1.32-2.59 1.22 0.927-1.6 1.22 0.927-1.6 0.851 0.592-1.22 0.383 1.04 0.739-1.48 0.805 1.15 0.818-1.61 0.427 FALSE FALSE FALSE FALSE Both 277 2770 GRCh37/hg19 auto 2020-06-08 prsweb-phecode204-20001-1048-lassosum-mgi-20200608 prsweb-phecode204-20001-1048-lassosum-mgi-20200608 PRSWEB_PHECODE204_20001-1048_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE204_20001-1048_LASSOSUM_MGI_20200608 204 Cancer code, self-reported: leukaemia Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative lassosum UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 349179 0.92 0.00137955 0.0826 0.505 0.469-0.541 OR 1.25 0.401-3.86 1.25 0.401-3.86 1.17 0.511-2.66 1.17 0.511-2.66 1.19 0.703-2.01 1.19 0.703-2.01 1.11 0.745-1.64 1.11 0.745-1.64 0.962 0.723-1.28 0.962 0.723-1.28 0.943 0.665-1.34 0.743 1.05 0.748-1.48 0.77 0.964 0.68-1.36 0.835 FALSE FALSE FALSE FALSE Both 277 2770 GRCh37/hg19 s=0.9;Lambda=0.04833 2020-06-08 prsweb-phecode204-ukbb-saige-hrc-x204-lassosum-mgi-20200608 prsweb-phecode204-ukbb-saige-hrc-x204-lassosum-mgi-20200608 PRSWEB_PHECODE204_UKBB-SAIGE-HRC-X204_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE204_UKBB-SAIGE-HRC-X204_LASSOSUM_MGI_20200608 204 Leukemia Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative lassosum UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 35027 0.095 0.00268568 0.0825 0.523 0.49-0.558 OR 2.3 0.959-5.51 2.3 0.959-5.51 2.84 1.59-5.07 2.84 1.59-5.07 1.91 1.23-2.97 1.91 1.23-2.97 1.64 1.15-2.32 1.64 1.15-2.32 1.07 0.804-1.41 1.07 0.804-1.41 1.1 0.767-1.57 0.61 1.25 0.884-1.78 0.204 1.22 0.857-1.75 0.266 FALSE FALSE FALSE FALSE Both 277 2770 GRCh37/hg19 s=0.5;Lambda=0.02976 2020-06-08 prsweb-phecode204-1-c91-p-5e-05-mgi-20200608 prsweb-phecode204-1-c91-p-5e-05-mgi-20200608 PRSWEB_PHECODE204.1_C91_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE204.1_C91_P_5e-05_MGI_20200608 204.1 Diagnoses - main ICD10: C91 Lymphoid leukaemia Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 91 0.82 8.98411e-07 0.0826 0.495 0.434-0.552 OR 2.64 0.604-11.5 2.64 0.604-11.5 3.66 1.43-9.42 3.66 1.43-9.42 1.73 0.765-3.9 1.73 0.765-3.9 1.21 0.61-2.4 1.21 0.61-2.4 0.903 0.539-1.51 0.903 0.539-1.51 1.1 0.604-2.02 0.747 1.11 0.605-2.03 0.738 0.882 0.472-1.65 0.695 FALSE FALSE FALSE FALSE Both 87 870 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode204-1-ukbb-saige-hrc-x204-1-p-5e-05-mgi-20200608 prsweb-phecode204-1-ukbb-saige-hrc-x204-1-p-5e-05-mgi-20200608 PRSWEB_PHECODE204.1_UKBB-SAIGE-HRC-X204.1_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE204.1_UKBB-SAIGE-HRC-X204.1_P_5e-05_MGI_20200608 204.1 Lymphoid leukemia Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 113 0.37 0.0050686 0.0825 0.523 0.452-0.591 OR 5.09 1.53-16.9 5.09 1.53-16.9 3.15 1.15-8.59 3.15 1.15-8.59 1.52 0.642-3.58 1.52 0.642-3.58 1.22 0.622-2.41 1.22 0.622-2.41 1.44 0.901-2.3 1.44 0.901-2.3 0.768 0.41-1.44 0.408 0.821 0.438-1.54 0.54 1.2 0.675-2.12 0.539 FALSE FALSE FALSE FALSE Both 87 870 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode204-1-c-lymphoid-leukaemia-p-5e-06-mgi-20200608 prsweb-phecode204-1-c-lymphoid-leukaemia-p-5e-06-mgi-20200608 PRSWEB_PHECODE204.1_C-LYMPHOID-LEUKAEMIA_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE204.1_C-LYMPHOID-LEUKAEMIA_P_5e-06_MGI_20200608 204.1 Lymphoid leukaemia Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 20 0.61 0.00369312 0.0826 0.511 0.45-0.58 OR 0 0-0 0 0-0 0.803 0.147-4.39 0.803 0.147-4.39 1 0.371-2.72 1 0.371-2.72 1.21 0.61-2.38 1.21 0.61-2.38 0.85 0.505-1.43 0.85 0.505-1.43 0.689 0.352-1.35 0.277 1.52 0.861-2.7 0.148 0.907 0.483-1.7 0.762 FALSE FALSE FALSE FALSE Both 87 870 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode204-1-c91-p-5e-06-mgi-20200608 prsweb-phecode204-1-c91-p-5e-06-mgi-20200608 PRSWEB_PHECODE204.1_C91_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE204.1_C91_P_5e-06_MGI_20200608 204.1 Diagnoses - main ICD10: C91 Lymphoid leukaemia Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 21 0.31 0.000109791 0.0825 0.521 0.453-0.588 OR 1.51 0.247-9.27 1.51 0.247-9.27 1.9 0.581-6.23 1.9 0.581-6.23 1.73 0.768-3.89 1.73 0.768-3.89 1.35 0.7-2.61 1.35 0.7-2.61 1.21 0.749-1.97 1.21 0.749-1.97 0.735 0.372-1.45 0.375 1.19 0.653-2.17 0.568 1.23 0.674-2.25 0.497 FALSE FALSE FALSE FALSE Both 87 870 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode204-1-ukbb-saige-hrc-x204-1-p-5e-06-mgi-20200608 prsweb-phecode204-1-ukbb-saige-hrc-x204-1-p-5e-06-mgi-20200608 PRSWEB_PHECODE204.1_UKBB-SAIGE-HRC-X204.1_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE204.1_UKBB-SAIGE-HRC-X204.1_P_5e-06_MGI_20200608 204.1 Lymphoid leukemia Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 25 0.13 0.00793421 0.0824 0.528 0.463-0.593 OR 1.59 0.259-9.81 1.59 0.259-9.81 2.54 0.862-7.48 2.54 0.862-7.48 1.24 0.497-3.1 1.24 0.497-3.1 1.35 0.699-2.6 1.35 0.699-2.6 1.28 0.797-2.07 1.28 0.797-2.07 0.743 0.387-1.43 0.371 1.03 0.567-1.88 0.921 1.16 0.647-2.07 0.621 FALSE FALSE FALSE FALSE Both 87 870 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode204-1-ukbb-saige-hrc-x204-1-p-5e-07-mgi-20200608 prsweb-phecode204-1-ukbb-saige-hrc-x204-1-p-5e-07-mgi-20200608 PRSWEB_PHECODE204.1_UKBB-SAIGE-HRC-X204.1_P_5e-07_MGI_20200608 P_5e-07 PRSWEB_PHECODE204.1_UKBB-SAIGE-HRC-X204.1_P_5e-07_MGI_20200608 204.1 Lymphoid leukemia Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative Fixed threshold (5e-07) UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 5 0.028 0.0152043 0.0823 0.557 0.506-0.614 OR 0 0-0 0 0-0 1.93 0.591-6.34 1.93 0.591-6.34 1.51 0.641-3.56 1.51 0.641-3.56 1.24 0.625-2.44 1.24 0.625-2.44 1.36 0.846-2.17 1.36 0.846-2.17 2.22 1.1-4.48 0.0257 1.99 0.98-4.04 0.057 2.32 1.16-4.64 0.0178 TRUE FALSE FALSE FALSE Both 87 870 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode204-1-c-lymphoid-leukaemia-pt-mgi-20200608 prsweb-phecode204-1-c-lymphoid-leukaemia-pt-mgi-20200608 PRSWEB_PHECODE204.1_C-LYMPHOID-LEUKAEMIA_PT_MGI_20200608 P&T PRSWEB_PHECODE204.1_C-LYMPHOID-LEUKAEMIA_PT_MGI_20200608 204.1 Lymphoid leukaemia Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative P&T UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 6 0.0026 0.0154783 0.0819 0.578 0.517-0.642 OR 3.69 1.01-13.4 3.69 1.01-13.4 2.53 0.864-7.44 2.53 0.864-7.44 1.99 0.919-4.31 1.99 0.919-4.31 1.78 0.968-3.27 1.78 0.968-3.27 1.66 1.05-2.63 1.66 1.05-2.63 1.55 0.773-3.11 0.216 1.75 0.885-3.47 0.108 2.38 1.24-4.57 0.00934 TRUE FALSE FALSE TRUE Both 87 870 GRCh37/hg19 P<=1e-06 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000645/ScoringFiles/ phewas/PRSWEB_PHECODE204.1_C-LYMPHOID-LEUKAEMIA_PT_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE204.1_C-LYMPHOID-LEUKAEMIA_PT_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode204-1-c91-pt-mgi-20200608 prsweb-phecode204-1-c91-pt-mgi-20200608 PRSWEB_PHECODE204.1_C91_PT_MGI_20200608 P&T PRSWEB_PHECODE204.1_C91_PT_MGI_20200608 204.1 Diagnoses - main ICD10: C91 Lymphoid leukaemia Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative P&T UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 6 0.18 0.00100075 0.0825 0.512 0.448-0.573 OR 1.57 0.256-9.68 1.57 0.256-9.68 1.36 0.347-5.35 1.36 0.347-5.35 1.77 0.783-4 1.77 0.783-4 1.66 0.889-3.08 1.66 0.889-3.08 1.03 0.625-1.7 1.03 0.625-1.7 1.98 1.03-3.81 0.0409 1.64 0.849-3.18 0.14 1.5 0.766-2.93 0.237 FALSE FALSE FALSE FALSE Both 87 870 GRCh37/hg19 P<=1.26e-06 2020-06-08 prsweb-phecode204-1-ukbb-saige-hrc-x204-1-pt-mgi-20200608 prsweb-phecode204-1-ukbb-saige-hrc-x204-1-pt-mgi-20200608 PRSWEB_PHECODE204.1_UKBB-SAIGE-HRC-X204.1_PT_MGI_20200608 P&T PRSWEB_PHECODE204.1_UKBB-SAIGE-HRC-X204.1_PT_MGI_20200608 204.1 Lymphoid leukemia Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative P&T UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 10 0.45 0.0177568 0.0826 0.498 0.442-0.561 OR 1.57 0.256-9.66 1.57 0.256-9.66 1.87 0.573-6.12 1.87 0.573-6.12 1.24 0.497-3.1 1.24 0.497-3.1 0.958 0.458-2 0.958 0.458-2 0.799 0.471-1.36 0.799 0.471-1.36 1.4 0.742-2.64 0.299 1.6 0.863-2.95 0.136 1.06 0.547-2.05 0.868 FALSE FALSE FALSE FALSE Both 87 870 GRCh37/hg19 P<=1.58e-06 2020-06-08 prsweb-phecode204-1-ukbb-saige-hrc-x204-1-prs-cs-mgi-20200608 prsweb-phecode204-1-ukbb-saige-hrc-x204-1-prs-cs-mgi-20200608 PRSWEB_PHECODE204.1_UKBB-SAIGE-HRC-X204.1_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE204.1_UKBB-SAIGE-HRC-X204.1_PRS-CS_MGI_20200608 204.1 Lymphoid leukemia Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative PRS-CS UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1119238 0.16 0.000591521 0.0824 0.532 0.466-0.601 OR 3.82 1.02-14.3 3.82 1.02-14.3 1.91 0.578-6.33 1.91 0.578-6.33 2.25 1.07-4.74 2.25 1.07-4.74 1.63 0.873-3.03 1.63 0.873-3.03 1.28 0.795-2.06 1.28 0.795-2.06 1.21 0.643-2.29 0.549 1.18 0.619-2.23 0.62 1.44 0.775-2.66 0.25 FALSE FALSE FALSE FALSE Both 87 870 GRCh37/hg19 auto 2020-06-08 prsweb-phecode204-1-c91-lassosum-mgi-20200608 prsweb-phecode204-1-c91-lassosum-mgi-20200608 PRSWEB_PHECODE204.1_C91_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE204.1_C91_LASSOSUM_MGI_20200608 204.1 Diagnoses - main ICD10: C91 Lymphoid leukaemia Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative lassosum UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 11436 0.88 0.00462042 0.0826 0.504 0.445-0.565 OR 1.58 0.259-9.59 1.58 0.259-9.59 0.795 0.145-4.37 0.795 0.145-4.37 1.24 0.497-3.11 1.24 0.497-3.11 0.956 0.457-2 0.956 0.457-2 0.847 0.504-1.43 0.847 0.504-1.43 1.09 0.578-2.05 0.792 1.41 0.778-2.56 0.256 0.985 0.518-1.87 0.964 FALSE FALSE FALSE FALSE Both 87 870 GRCh37/hg19 s=0.9;Lambda=0.07848 2020-06-08 prsweb-phecode204-1-ukbb-saige-hrc-x204-1-lassosum-mgi-20200608 prsweb-phecode204-1-ukbb-saige-hrc-x204-1-lassosum-mgi-20200608 PRSWEB_PHECODE204.1_UKBB-SAIGE-HRC-X204.1_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE204.1_UKBB-SAIGE-HRC-X204.1_LASSOSUM_MGI_20200608 204.1 Lymphoid leukemia Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative lassosum UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 14079 0.81 0.0118882 0.0826 0.502 0.432-0.566 OR 2.68 0.615-11.7 2.68 0.615-11.7 1.94 0.592-6.37 1.94 0.592-6.37 2.01 0.926-4.37 2.01 0.926-4.37 1.22 0.617-2.41 1.22 0.617-2.41 1.35 0.843-2.17 1.35 0.843-2.17 0.605 0.323-1.14 0.118 0.621 0.335-1.15 0.131 0.97 0.556-1.69 0.914 FALSE FALSE FALSE FALSE Both 87 870 GRCh37/hg19 s=0.9;Lambda=0.06158 2020-06-08 prsweb-phecode204-11-gwas-catalog-r2019-05-03-x204-11-p-5e-05-mgi-20200608 prsweb-phecode204-11-gwas-catalog-r2019-05-03-x204-11-p-5e-05-mgi-20200608 PRSWEB_PHECODE204.11_GWAS-Catalog-r2019-05-03-X204.11_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE204.11_GWAS-Catalog-r2019-05-03-X204.11_P_5e-05_MGI_20200608 204.11 Acute lymphoblastic leukemia (childhood);Acute lymphoblastic leukemia (B-cell precursor);Acute lymphoblastic leukemia in childhood (B cell precursor) Binary 31 unique SNPs MGI Michigan Genomics Initiative Fixed threshold (5e-05) GWAS Catalog (2019-05-03) 19684603;19684604;22076464;23996088;25310577;29296818 https://www.ncbi.nlm.nih.gov/pubmed/?term=19684603+19684604+22076464+23996088+25310577+29296818 25 0.16 0.00525151 0.0824 0.581 0.478-0.679 OR 0 0-0 0 0-0 0.588 0.0279-12.4 0.588 0.0279-12.4 0.773 0.131-4.56 0.773 0.131-4.56 1 0.306-3.29 1 0.306-3.29 0.83 0.352-1.96 0.83 0.352-1.96 1.4 0.474-4.12 0.544 2.72 0.995-7.44 0.0512 1.37 0.442-4.23 0.588 FALSE FALSE FALSE FALSE Both 33 330 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode204-11-gwas-catalog-r2019-05-03-x204-11-p-5e-06-mgi-20200608 prsweb-phecode204-11-gwas-catalog-r2019-05-03-x204-11-p-5e-06-mgi-20200608 PRSWEB_PHECODE204.11_GWAS-Catalog-r2019-05-03-X204.11_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE204.11_GWAS-Catalog-r2019-05-03-X204.11_P_5e-06_MGI_20200608 204.11 Acute lymphoblastic leukemia (childhood);Acute lymphoblastic leukemia (B-cell precursor);Acute lymphoblastic leukemia in childhood (B cell precursor) Binary 31 unique SNPs MGI Michigan Genomics Initiative Fixed threshold (5e-06) GWAS Catalog (2019-05-03) 19684603;19684604;22076464;23996088;25310577;29296818 https://www.ncbi.nlm.nih.gov/pubmed/?term=19684603+19684604+22076464+23996088+25310577+29296818 17 0.58 0.00591395 0.0827 0.54 0.448-0.633 OR 0 0-0 0 0-0 0.645 0.0327-12.7 0.645 0.0327-12.7 0.245 0.0148-4.06 0.245 0.0148-4.06 0.389 0.0737-2.05 0.389 0.0737-2.05 0.836 0.354-1.97 0.836 0.354-1.97 1.87 0.616-5.65 0.27 2.78 0.948-8.13 0.0626 1.34 0.409-4.39 0.629 FALSE FALSE FALSE FALSE Both 33 330 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode204-11-ukbb-saige-hrc-x204-11-p-5e-06-mgi-20200608 prsweb-phecode204-11-ukbb-saige-hrc-x204-11-p-5e-06-mgi-20200608 PRSWEB_PHECODE204.11_UKBB-SAIGE-HRC-X204.11_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE204.11_UKBB-SAIGE-HRC-X204.11_P_5e-06_MGI_20200608 204.11 Lymphoid leukemia, acute Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 7 0.99 0.00717079 0.0827 0.482 0.382-0.578 OR 0 0-0 0 0-0 0.614 0.0288-13.1 0.614 0.0288-13.1 0.261 0.0155-4.4 0.261 0.0155-4.4 1.01 0.32-3.19 1.01 0.32-3.19 1.3 0.605-2.77 1.3 0.605-2.77 0.698 0.26-1.88 0.476 0.932 0.365-2.38 0.884 0.975 0.383-2.48 0.957 FALSE FALSE FALSE FALSE Both 33 330 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode204-11-gwas-catalog-r2019-05-03-x204-11-p-5e-07-mgi-20200608 prsweb-phecode204-11-gwas-catalog-r2019-05-03-x204-11-p-5e-07-mgi-20200608 PRSWEB_PHECODE204.11_GWAS-Catalog-r2019-05-03-X204.11_P_5e-07_MGI_20200608 P_5e-07 PRSWEB_PHECODE204.11_GWAS-Catalog-r2019-05-03-X204.11_P_5e-07_MGI_20200608 204.11 Acute lymphoblastic leukemia (childhood);Acute lymphoblastic leukemia (B-cell precursor);Acute lymphoblastic leukemia in childhood (B cell precursor) Binary 31 unique SNPs MGI Michigan Genomics Initiative Fixed threshold (5e-07) GWAS Catalog (2019-05-03) 19684603;19684604;22076464;23996088;25310577;29296818 https://www.ncbi.nlm.nih.gov/pubmed/?term=19684603+19684604+22076464+23996088+25310577+29296818 10 0.51 0.00238562 0.0827 0.543 0.451-0.632 OR 0 0-0 0 0-0 0.657 0.0332-13 0.657 0.0332-13 0.264 0.0172-4.06 0.264 0.0172-4.06 0.687 0.183-2.57 0.687 0.183-2.57 1.35 0.621-2.92 1.35 0.621-2.92 1.23 0.379-4 0.73 2.82 0.967-8.22 0.0577 2.13 0.691-6.6 0.188 FALSE FALSE FALSE FALSE Both 33 330 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode204-11-gwas-catalog-r2019-05-03-x204-11-p-5e-09-mgi-20200608 prsweb-phecode204-11-gwas-catalog-r2019-05-03-x204-11-p-5e-09-mgi-20200608 PRSWEB_PHECODE204.11_GWAS-Catalog-r2019-05-03-X204.11_P_5e-09_MGI_20200608 P_5e-09 PRSWEB_PHECODE204.11_GWAS-Catalog-r2019-05-03-X204.11_P_5e-09_MGI_20200608 204.11 Acute lymphoblastic leukemia (childhood);Acute lymphoblastic leukemia (B-cell precursor);Acute lymphoblastic leukemia in childhood (B cell precursor) Binary 31 unique SNPs MGI Michigan Genomics Initiative Fixed threshold (5e-09) GWAS Catalog (2019-05-03) 19684603;19684604;22076464;23996088;25310577;29296818 https://www.ncbi.nlm.nih.gov/pubmed/?term=19684603+19684604+22076464+23996088+25310577+29296818 5 0.37 0.00530996 0.0826 0.534 0.426-0.65 OR 2.64 0.348-20 2.64 0.348-20 1.96 0.291-13.2 1.96 0.291-13.2 1.41 0.353-5.59 1.41 0.353-5.59 0.699 0.189-2.59 0.699 0.189-2.59 1.53 0.723-3.22 1.53 0.723-3.22 0.306 0.0891-1.05 0.0598 1.08 0.431-2.71 0.867 1.28 0.519-3.15 0.594 FALSE FALSE FALSE FALSE Both 33 330 GRCh37/hg19 P<=5e-09 2020-06-08 prsweb-phecode204-11-gwas-catalog-r2019-05-03-x204-11-p-5e-08-mgi-20200608 prsweb-phecode204-11-gwas-catalog-r2019-05-03-x204-11-p-5e-08-mgi-20200608 PRSWEB_PHECODE204.11_GWAS-Catalog-r2019-05-03-X204.11_P_5e-08_MGI_20200608 P_5e-08 PRSWEB_PHECODE204.11_GWAS-Catalog-r2019-05-03-X204.11_P_5e-08_MGI_20200608 204.11 Acute lymphoblastic leukemia (childhood);Acute lymphoblastic leukemia (B-cell precursor);Acute lymphoblastic leukemia in childhood (B cell precursor) Binary 31 unique SNPs MGI Michigan Genomics Initiative GWAS Hits GWAS Catalog (2019-05-03) 19684603;19684604;22076464;23996088;25310577;29296818 https://www.ncbi.nlm.nih.gov/pubmed/?term=19684603+19684604+22076464+23996088+25310577+29296818 7 0.24 0.00219108 0.0824 0.558 0.451-0.662 OR 3.64 0.441-30.1 3.64 0.441-30.1 2.02 0.304-13.4 2.02 0.304-13.4 1.44 0.356-5.83 1.44 0.356-5.83 1.68 0.622-4.53 1.68 0.622-4.53 1.13 0.517-2.48 1.13 0.517-2.48 0.677 0.214-2.14 0.507 2.21 0.855-5.73 0.102 1.5 0.534-4.23 0.44 FALSE FALSE FALSE FALSE Both 33 330 GRCh37/hg19 P<=5e-08 2020-06-08 prsweb-phecode204-11-gwas-catalog-r2019-05-03-x204-11-pt-mgi-20200608 prsweb-phecode204-11-gwas-catalog-r2019-05-03-x204-11-pt-mgi-20200608 PRSWEB_PHECODE204.11_GWAS-Catalog-r2019-05-03-X204.11_PT_MGI_20200608 P&T PRSWEB_PHECODE204.11_GWAS-Catalog-r2019-05-03-X204.11_PT_MGI_20200608 204.11 Acute lymphoblastic leukemia (childhood);Acute lymphoblastic leukemia (B-cell precursor);Acute lymphoblastic leukemia in childhood (B cell precursor) Binary 31 unique SNPs MGI Michigan Genomics Initiative P&T GWAS Catalog (2019-05-03) 19684603;19684604;22076464;23996088;25310577;29296818 https://www.ncbi.nlm.nih.gov/pubmed/?term=19684603+19684604+22076464+23996088+25310577+29296818 21 0.4 0.00917179 0.0826 0.559 0.461-0.657 OR 0 0-0 0 0-0 0.591 0.0282-12.4 0.591 0.0282-12.4 0.254 0.0154-4.2 0.254 0.0154-4.2 0.674 0.174-2.62 0.674 0.174-2.62 1.35 0.618-2.94 1.35 0.618-2.94 1.39 0.433-4.44 0.583 2.99 0.995-8.98 0.051 1.91 0.601-6.08 0.272 FALSE FALSE FALSE FALSE Both 33 330 GRCh37/hg19 P<=7.94e-06 2020-06-08 prsweb-phecode204-11-gwas-catalog-r2019-05-03-x204-11-p-5e-09-ukb-20200608 prsweb-phecode204-11-gwas-catalog-r2019-05-03-x204-11-p-5e-09-ukb-20200608 PRSWEB_PHECODE204.11_GWAS-Catalog-r2019-05-03-X204.11_P_5e-09_UKB_20200608 P_5e-09 PRSWEB_PHECODE204.11_GWAS-Catalog-r2019-05-03-X204.11_P_5e-09_UKB_20200608 204.11 Acute lymphoblastic leukemia (childhood);Acute lymphoblastic leukemia (B-cell precursor);Acute lymphoblastic leukemia in childhood (B cell precursor) Binary 31 unique SNPs UKB UK Biobank Fixed threshold (5e-09) GWAS Catalog (2019-05-03) 19684603;19684604;22076464;23996088;25310577;29296818 https://www.ncbi.nlm.nih.gov/pubmed/?term=19684603+19684604+22076464+23996088+25310577+29296818 5 0.91 0.00135749 0.0828 0.476 0.355-0.605 OR 0 0-0 0 0-0 0.85 0.037-19.5 0.85 0.037-19.5 1.88 0.445-7.93 1.88 0.445-7.93 1.63 0.55-4.84 1.63 0.55-4.84 1.19 0.496-2.85 1.19 0.496-2.85 0.967 0.352-2.66 0.948 0.468 0.138-1.59 0.224 0.943 0.343-2.59 0.91 FALSE FALSE FALSE FALSE Both 25 250 GRCh37/hg19 P<=5e-09 2020-06-08 prsweb-phecode204-12-gwas-catalog-r2019-05-03-x204-12-p-5e-05-mgi-20200608 prsweb-phecode204-12-gwas-catalog-r2019-05-03-x204-12-p-5e-05-mgi-20200608 PRSWEB_PHECODE204.12_GWAS-Catalog-r2019-05-03-X204.12_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE204.12_GWAS-Catalog-r2019-05-03-X204.12_P_5e-05_MGI_20200608 204.12 Chronic lymphocytic leukemia Binary 66 unique SNPs MGI Michigan Genomics Initiative Fixed threshold (5e-05) GWAS Catalog (2019-05-03) 18758461;21131588;22700719;23770605;24292274;26956414;28165464 https://www.ncbi.nlm.nih.gov/pubmed/?term=18758461+21131588+22700719+23770605+24292274+26956414+28165464 44 6.1e-09 0.0557503 0.0776 0.696 0.621-0.764 OR 12.9 4.45-37.6 12.9 4.45-37.6 8.85 3.66-21.4 8.85 3.66-21.4 6.28 3.27-12.1 6.28 3.27-12.1 4.57 2.61-8 4.57 2.61-8 2.9 1.77-4.75 2.9 1.77-4.75 1.36 0.536-3.43 0.521 2.51 1.09-5.79 0.0307 4.37 1.96-9.71 3e-04 TRUE FALSE FALSE FALSE Both 69 687 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode204-12-ukbb-saige-hrc-x204-12-p-5e-05-mgi-20200608 prsweb-phecode204-12-ukbb-saige-hrc-x204-12-p-5e-05-mgi-20200608 PRSWEB_PHECODE204.12_UKBB-SAIGE-HRC-X204.12_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE204.12_UKBB-SAIGE-HRC-X204.12_P_5e-05_MGI_20200608 204.12 Lymphoid leukemia, chronic Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 125 0.14 7.19398e-05 0.0827 0.546 0.476-0.615 OR 3.51 0.747-16.5 3.51 0.747-16.5 1.75 0.431-7.12 1.75 0.431-7.12 1.92 0.791-4.66 1.92 0.791-4.66 1.59 0.787-3.22 1.59 0.787-3.22 1.43 0.843-2.42 1.43 0.843-2.42 0.984 0.482-2.01 0.964 1.1 0.542-2.22 0.8 1.41 0.72-2.76 0.317 FALSE FALSE FALSE FALSE Both 69 687 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode204-12-gwas-catalog-r2019-05-03-x204-12-p-5e-06-mgi-20200608 prsweb-phecode204-12-gwas-catalog-r2019-05-03-x204-12-p-5e-06-mgi-20200608 PRSWEB_PHECODE204.12_GWAS-Catalog-r2019-05-03-X204.12_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE204.12_GWAS-Catalog-r2019-05-03-X204.12_P_5e-06_MGI_20200608 204.12 Chronic lymphocytic leukemia Binary 66 unique SNPs MGI Michigan Genomics Initiative Fixed threshold (5e-06) GWAS Catalog (2019-05-03) 18758461;21131588;22700719;23770605;24292274;26956414;28165464 https://www.ncbi.nlm.nih.gov/pubmed/?term=18758461+21131588+22700719+23770605+24292274+26956414+28165464 43 4.7e-09 0.0544729 0.0775 0.698 0.623-0.766 OR 15.2 5.32-43.4 15.2 5.32-43.4 8.85 3.66-21.4 8.85 3.66-21.4 6.77 3.55-12.9 6.77 3.55-12.9 4.26 2.42-7.48 4.26 2.42-7.48 3.06 1.87-5.03 3.06 1.87-5.03 1.22 0.473-3.14 0.682 2.43 1.05-5.6 0.0376 4.59 2.07-10.2 0.000177 TRUE FALSE FALSE FALSE Both 69 687 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode204-12-ukbb-saige-hrc-x204-12-p-5e-06-mgi-20200608 prsweb-phecode204-12-ukbb-saige-hrc-x204-12-p-5e-06-mgi-20200608 PRSWEB_PHECODE204.12_UKBB-SAIGE-HRC-X204.12_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE204.12_UKBB-SAIGE-HRC-X204.12_P_5e-06_MGI_20200608 204.12 Lymphoid leukemia, chronic Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 24 0.31 0.000154583 0.0828 0.521 0.447-0.598 OR 1.96 0.299-12.8 1.96 0.299-12.8 1.73 0.424-7.09 1.73 0.424-7.09 1.89 0.777-4.57 1.89 0.777-4.57 1.57 0.777-3.18 1.57 0.777-3.18 1.61 0.961-2.7 1.61 0.961-2.7 0.973 0.486-1.95 0.939 0.802 0.381-1.69 0.563 1.42 0.739-2.72 0.294 FALSE FALSE FALSE FALSE Both 69 687 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode204-12-gwas-catalog-r2019-05-03-x204-12-p-5e-07-mgi-20200608 prsweb-phecode204-12-gwas-catalog-r2019-05-03-x204-12-p-5e-07-mgi-20200608 PRSWEB_PHECODE204.12_GWAS-Catalog-r2019-05-03-X204.12_P_5e-07_MGI_20200608 P_5e-07 PRSWEB_PHECODE204.12_GWAS-Catalog-r2019-05-03-X204.12_P_5e-07_MGI_20200608 204.12 Chronic lymphocytic leukemia Binary 66 unique SNPs MGI Michigan Genomics Initiative Fixed threshold (5e-07) GWAS Catalog (2019-05-03) 18758461;21131588;22700719;23770605;24292274;26956414;28165464 https://www.ncbi.nlm.nih.gov/pubmed/?term=18758461+21131588+22700719+23770605+24292274+26956414+28165464 40 7.6e-09 0.055405 0.0778 0.698 0.624-0.768 OR 12.5 4.36-36.1 12.5 4.36-36.1 6.53 2.61-16.3 6.53 2.61-16.3 6.29 3.27-12.1 6.29 3.27-12.1 4.82 2.77-8.39 4.82 2.77-8.39 3.26 1.98-5.35 3.26 1.98-5.35 0.79 0.3-2.08 0.632 2.18 0.977-4.89 0.0571 4.15 1.95-8.86 0.000233 TRUE FALSE FALSE FALSE Both 69 687 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode204-12-ukbb-saige-hrc-x204-12-p-5e-07-mgi-20200608 prsweb-phecode204-12-ukbb-saige-hrc-x204-12-p-5e-07-mgi-20200608 PRSWEB_PHECODE204.12_UKBB-SAIGE-HRC-X204.12_P_5e-07_MGI_20200608 P_5e-07 PRSWEB_PHECODE204.12_UKBB-SAIGE-HRC-X204.12_P_5e-07_MGI_20200608 204.12 Lymphoid leukemia, chronic Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative Fixed threshold (5e-07) UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 6 0.0054 0.0173877 0.0822 0.577 0.511-0.645 OR 2 0.308-13 2 0.308-13 2.47 0.725-8.43 2.47 0.725-8.43 2.53 1.14-5.6 2.53 1.14-5.6 1.57 0.781-3.15 1.57 0.781-3.15 1.23 0.722-2.11 1.23 0.722-2.11 1.7 0.702-4.12 0.239 3.96 1.77-8.86 0.000809 2.84 1.22-6.58 0.015 TRUE FALSE FALSE FALSE Both 69 687 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode204-12-gwas-catalog-r2019-05-03-x204-12-p-5e-09-mgi-20200608 prsweb-phecode204-12-gwas-catalog-r2019-05-03-x204-12-p-5e-09-mgi-20200608 PRSWEB_PHECODE204.12_GWAS-Catalog-r2019-05-03-X204.12_P_5e-09_MGI_20200608 P_5e-09 PRSWEB_PHECODE204.12_GWAS-Catalog-r2019-05-03-X204.12_P_5e-09_MGI_20200608 204.12 Chronic lymphocytic leukemia Binary 66 unique SNPs MGI Michigan Genomics Initiative Fixed threshold (5e-09) GWAS Catalog (2019-05-03) 18758461;21131588;22700719;23770605;24292274;26956414;28165464 https://www.ncbi.nlm.nih.gov/pubmed/?term=18758461+21131588+22700719+23770605+24292274+26956414+28165464 23 5.1e-08 0.0371243 0.0784 0.688 0.618-0.758 OR 11.1 3.68-33.4 11.1 3.68-33.4 6.49 2.58-16.3 6.49 2.58-16.3 6.86 3.58-13.1 6.86 3.58-13.1 4.67 2.66-8.22 4.67 2.66-8.22 2.78 1.69-4.58 2.78 1.69-4.58 1.16 0.454-2.99 0.752 2.87 1.25-6.6 0.0132 4.37 1.96-9.76 0.000316 TRUE FALSE FALSE FALSE Both 69 687 GRCh37/hg19 P<=5e-09 2020-06-08 prsweb-phecode204-12-gwas-catalog-r2019-05-03-x204-12-p-5e-08-mgi-20200608 prsweb-phecode204-12-gwas-catalog-r2019-05-03-x204-12-p-5e-08-mgi-20200608 PRSWEB_PHECODE204.12_GWAS-Catalog-r2019-05-03-X204.12_P_5e-08_MGI_20200608 P_5e-08 PRSWEB_PHECODE204.12_GWAS-Catalog-r2019-05-03-X204.12_P_5e-08_MGI_20200608 204.12 Chronic lymphocytic leukemia Binary 66 unique SNPs MGI Michigan Genomics Initiative GWAS Hits GWAS Catalog (2019-05-03) 18758461;21131588;22700719;23770605;24292274;26956414;28165464 https://www.ncbi.nlm.nih.gov/pubmed/?term=18758461+21131588+22700719+23770605+24292274+26956414+28165464 32 1.3e-08 0.0457519 0.0779 0.696 0.628-0.765 OR 11.3 3.76-33.9 11.3 3.76-33.9 8.41 3.51-20.1 8.41 3.51-20.1 6.81 3.57-13 6.81 3.57-13 4.45 2.51-7.9 4.45 2.51-7.9 2.9 1.77-4.75 2.9 1.77-4.75 1.28 0.515-3.18 0.594 2.42 1.05-5.61 0.0385 4.3 1.94-9.52 0.00033 TRUE FALSE FALSE TRUE Both 69 687 GRCh37/hg19 P<=5e-08 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000646/ScoringFiles/ phewas/PRSWEB_PHECODE204.12_GWAS-Catalog-r2019-05-03-X204.12_P_5e-08_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE204.12_GWAS-Catalog-r2019-05-03-X204.12_P_5e-08_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode204-12-20001-1055-pt-mgi-20200608 prsweb-phecode204-12-20001-1055-pt-mgi-20200608 PRSWEB_PHECODE204.12_20001-1055_PT_MGI_20200608 P&T PRSWEB_PHECODE204.12_20001-1055_PT_MGI_20200608 204.12 Cancer code, self-reported: chronic lymphocytic Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative P&T UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 7 0.22 0.00150579 0.0828 0.522 0.452-0.593 OR 1.93 0.295-12.6 1.93 0.295-12.6 3.24 1.05-10 3.24 1.05-10 1.26 0.457-3.46 1.26 0.457-3.46 1.56 0.779-3.14 1.56 0.779-3.14 1.24 0.725-2.12 1.24 0.725-2.12 1.22 0.605-2.47 0.574 1.22 0.59-2.51 0.595 1.4 0.7-2.79 0.343 FALSE FALSE FALSE FALSE Both 69 687 GRCh37/hg19 P<=1.58e-06 2020-06-08 prsweb-phecode204-12-gwas-catalog-r2019-05-03-x204-12-pt-mgi-20200608 prsweb-phecode204-12-gwas-catalog-r2019-05-03-x204-12-pt-mgi-20200608 PRSWEB_PHECODE204.12_GWAS-Catalog-r2019-05-03-X204.12_PT_MGI_20200608 P&T PRSWEB_PHECODE204.12_GWAS-Catalog-r2019-05-03-X204.12_PT_MGI_20200608 204.12 Chronic lymphocytic leukemia Binary 66 unique SNPs MGI Michigan Genomics Initiative P&T GWAS Catalog (2019-05-03) 18758461;21131588;22700719;23770605;24292274;26956414;28165464 https://www.ncbi.nlm.nih.gov/pubmed/?term=18758461+21131588+22700719+23770605+24292274+26956414+28165464 44 6.1e-09 0.0557503 0.0776 0.696 0.621-0.764 OR 12.9 4.45-37.6 12.9 4.45-37.6 8.85 3.66-21.4 8.85 3.66-21.4 6.28 3.27-12.1 6.28 3.27-12.1 4.57 2.61-8 4.57 2.61-8 2.9 1.77-4.75 2.9 1.77-4.75 1.36 0.536-3.43 0.521 2.51 1.09-5.79 0.0307 4.37 1.96-9.71 3e-04 TRUE FALSE FALSE TRUE Both 69 687 GRCh37/hg19 P<=7e-06 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000648/ScoringFiles/ phewas/PRSWEB_PHECODE204.12_GWAS-Catalog-r2019-05-03-X204.12_PT_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE204.12_GWAS-Catalog-r2019-05-03-X204.12_PT_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode204-12-ukbb-saige-hrc-x204-12-pt-mgi-20200608 prsweb-phecode204-12-ukbb-saige-hrc-x204-12-pt-mgi-20200608 PRSWEB_PHECODE204.12_UKBB-SAIGE-HRC-X204.12_PT_MGI_20200608 P&T PRSWEB_PHECODE204.12_UKBB-SAIGE-HRC-X204.12_PT_MGI_20200608 204.12 Lymphoid leukemia, chronic Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative P&T UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 6 0.0054 0.0173877 0.0822 0.577 0.511-0.645 OR 2 0.308-13 2 0.308-13 2.47 0.725-8.43 2.47 0.725-8.43 2.53 1.14-5.6 2.53 1.14-5.6 1.57 0.781-3.15 1.57 0.781-3.15 1.23 0.722-2.11 1.23 0.722-2.11 1.7 0.702-4.12 0.239 3.96 1.77-8.86 0.000809 2.84 1.22-6.58 0.015 TRUE FALSE FALSE TRUE Both 69 687 GRCh37/hg19 P<=3.98e-07 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000650/ScoringFiles/ phewas/PRSWEB_PHECODE204.12_UKBB-SAIGE-HRC-X204.12_PT_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE204.12_UKBB-SAIGE-HRC-X204.12_PT_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode204-12-ukbb-saige-hrc-x204-12-prs-cs-mgi-20200608 prsweb-phecode204-12-ukbb-saige-hrc-x204-12-prs-cs-mgi-20200608 PRSWEB_PHECODE204.12_UKBB-SAIGE-HRC-X204.12_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE204.12_UKBB-SAIGE-HRC-X204.12_PRS-CS_MGI_20200608 204.12 Lymphoid leukemia, chronic Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative PRS-CS UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1119238 0.16 6.53567e-06 0.0826 0.557 0.482-0.634 OR 1.91 0.294-12.5 1.91 0.294-12.5 1 0.178-5.66 1 0.178-5.66 2.18 0.946-5.01 2.18 0.946-5.01 1.93 0.997-3.72 1.93 0.997-3.72 1.73 1.04-2.89 1.73 1.04-2.89 1.05 0.519-2.14 0.884 0.92 0.436-1.94 0.827 1.69 0.873-3.26 0.12 FALSE FALSE FALSE FALSE Both 69 687 GRCh37/hg19 auto 2020-06-08 prsweb-phecode204-12-20001-1055-lassosum-mgi-20200608 prsweb-phecode204-12-20001-1055-lassosum-mgi-20200608 PRSWEB_PHECODE204.12_20001-1055_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE204.12_20001-1055_LASSOSUM_MGI_20200608 204.12 Cancer code, self-reported: chronic lymphocytic Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative lassosum UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 3533 0.88 0.00735335 0.0829 0.498 0.423-0.565 OR 0 0-0 0 0-0 0.334 0.0188-5.93 0.334 0.0188-5.93 1.25 0.454-3.46 1.25 0.454-3.46 1.58 0.784-3.19 1.58 0.784-3.19 1.08 0.619-1.88 1.08 0.619-1.88 1.12 0.575-2.17 0.742 0.929 0.46-1.88 0.837 1.09 0.552-2.17 0.796 FALSE FALSE FALSE FALSE Both 69 687 GRCh37/hg19 s=0.5;Lambda=0.1 2020-06-08 prsweb-phecode204-12-ukbb-saige-hrc-x204-12-lassosum-mgi-20200608 prsweb-phecode204-12-ukbb-saige-hrc-x204-12-lassosum-mgi-20200608 PRSWEB_PHECODE204.12_UKBB-SAIGE-HRC-X204.12_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE204.12_UKBB-SAIGE-HRC-X204.12_LASSOSUM_MGI_20200608 204.12 Lymphoid leukemia, chronic Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative lassosum UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 76 0.022 0.00431619 0.0823 0.573 0.503-0.644 OR 4.84 1.23-19 4.84 1.23-19 2.47 0.722-8.45 2.47 0.722-8.45 2.23 0.963-5.16 2.23 0.963-5.16 2.15 1.12-4.1 2.15 1.12-4.1 1.24 0.723-2.13 1.24 0.723-2.13 1.06 0.477-2.34 0.893 2.33 1.13-4.78 0.0217 1.7 0.807-3.57 0.163 TRUE FALSE FALSE TRUE Both 69 687 GRCh37/hg19 s=0.5;Lambda=0.1 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000651/ScoringFiles/ phewas/PRSWEB_PHECODE204.12_UKBB-SAIGE-HRC-X204.12_LASSOSUM_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE204.12_UKBB-SAIGE-HRC-X204.12_LASSOSUM_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode204-12-gwas-catalog-r2019-05-03-x204-12-p-5e-05-ukb-20200608 prsweb-phecode204-12-gwas-catalog-r2019-05-03-x204-12-p-5e-05-ukb-20200608 PRSWEB_PHECODE204.12_GWAS-Catalog-r2019-05-03-X204.12_P_5e-05_UKB_20200608 P_5e-05 PRSWEB_PHECODE204.12_GWAS-Catalog-r2019-05-03-X204.12_P_5e-05_UKB_20200608 204.12 Chronic lymphocytic leukemia Binary 66 unique SNPs UKB UK Biobank Fixed threshold (5e-05) GWAS Catalog (2019-05-03) 18758461;21131588;22700719;23770605;24292274;26956414;28165464 https://www.ncbi.nlm.nih.gov/pubmed/?term=18758461+21131588+22700719+23770605+24292274+26956414+28165464 44 5.4e-22 0.0948333 0.0794 0.691 0.659-0.721 OR 2.5 1.03-6.06 2.5 1.03-6.06 2.74 1.47-5.09 2.74 1.47-5.09 2.92 1.94-4.38 2.92 1.94-4.38 3.01 2.19-4.12 3.01 2.19-4.12 3.32 2.55-4.32 3.32 2.55-4.32 1.94 1.11-3.39 0.0207 3.53 2.1-5.93 1.98e-06 7.13 4.34-11.7 7.79e-15 TRUE FALSE FALSE FALSE Both 249 2509 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode204-12-gwas-catalog-r2019-05-03-x204-12-p-5e-06-ukb-20200608 prsweb-phecode204-12-gwas-catalog-r2019-05-03-x204-12-p-5e-06-ukb-20200608 PRSWEB_PHECODE204.12_GWAS-Catalog-r2019-05-03-X204.12_P_5e-06_UKB_20200608 P_5e-06 PRSWEB_PHECODE204.12_GWAS-Catalog-r2019-05-03-X204.12_P_5e-06_UKB_20200608 204.12 Chronic lymphocytic leukemia Binary 66 unique SNPs UKB UK Biobank Fixed threshold (5e-06) GWAS Catalog (2019-05-03) 18758461;21131588;22700719;23770605;24292274;26956414;28165464 https://www.ncbi.nlm.nih.gov/pubmed/?term=18758461+21131588+22700719+23770605+24292274+26956414+28165464 43 7e-22 0.0943223 0.0794 0.689 0.657-0.72 OR 2.5 1.03-6.06 2.5 1.03-6.06 2.74 1.47-5.08 2.74 1.47-5.08 2.91 1.94-4.37 2.91 1.94-4.37 2.88 2.09-3.95 2.88 2.09-3.95 3.37 2.59-4.39 3.37 2.59-4.39 2.21 1.26-3.89 0.00577 3.56 2.09-6.06 3.04e-06 7.62 4.59-12.6 4.18e-15 TRUE FALSE FALSE FALSE Both 249 2509 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode204-12-gwas-catalog-r2019-05-03-x204-12-p-5e-07-ukb-20200608 prsweb-phecode204-12-gwas-catalog-r2019-05-03-x204-12-p-5e-07-ukb-20200608 PRSWEB_PHECODE204.12_GWAS-Catalog-r2019-05-03-X204.12_P_5e-07_UKB_20200608 P_5e-07 PRSWEB_PHECODE204.12_GWAS-Catalog-r2019-05-03-X204.12_P_5e-07_UKB_20200608 204.12 Chronic lymphocytic leukemia Binary 66 unique SNPs UKB UK Biobank Fixed threshold (5e-07) GWAS Catalog (2019-05-03) 18758461;21131588;22700719;23770605;24292274;26956414;28165464 https://www.ncbi.nlm.nih.gov/pubmed/?term=18758461+21131588+22700719+23770605+24292274+26956414+28165464 40 3.1e-21 0.094938 0.0795 0.684 0.652-0.714 OR 2.51 1.04-6.07 2.51 1.04-6.07 2.95 1.61-5.4 2.95 1.61-5.4 3.23 2.17-4.79 3.23 2.17-4.79 2.75 1.99-3.79 2.75 1.99-3.79 2.97 2.29-3.87 2.97 2.29-3.87 1.95 1.13-3.37 0.0158 3.48 2.1-5.79 1.47e-06 6.39 3.93-10.4 7.2e-14 TRUE FALSE FALSE FALSE Both 249 2509 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode204-12-gwas-catalog-r2019-05-03-x204-12-p-5e-09-ukb-20200608 prsweb-phecode204-12-gwas-catalog-r2019-05-03-x204-12-p-5e-09-ukb-20200608 PRSWEB_PHECODE204.12_GWAS-Catalog-r2019-05-03-X204.12_P_5e-09_UKB_20200608 P_5e-09 PRSWEB_PHECODE204.12_GWAS-Catalog-r2019-05-03-X204.12_P_5e-09_UKB_20200608 204.12 Chronic lymphocytic leukemia Binary 66 unique SNPs UKB UK Biobank Fixed threshold (5e-09) GWAS Catalog (2019-05-03) 18758461;21131588;22700719;23770605;24292274;26956414;28165464 https://www.ncbi.nlm.nih.gov/pubmed/?term=18758461+21131588+22700719+23770605+24292274+26956414+28165464 23 3.2e-18 0.0910057 0.0798 0.667 0.632-0.699 OR 2.52 1.04-6.09 2.52 1.04-6.09 2.95 1.61-5.39 2.95 1.61-5.39 2.82 1.87-4.24 2.82 1.87-4.24 3.12 2.28-4.26 3.12 2.28-4.26 2.57 1.97-3.34 2.57 1.97-3.34 2 1.21-3.3 0.00672 2.8 1.73-4.51 2.54e-05 4.88 3.11-7.68 6.66e-12 TRUE FALSE FALSE FALSE Both 249 2509 GRCh37/hg19 P<=5e-09 2020-06-08 prsweb-phecode204-12-gwas-catalog-r2019-05-03-x204-12-p-5e-08-ukb-20200608 prsweb-phecode204-12-gwas-catalog-r2019-05-03-x204-12-p-5e-08-ukb-20200608 PRSWEB_PHECODE204.12_GWAS-Catalog-r2019-05-03-X204.12_P_5e-08_UKB_20200608 P_5e-08 PRSWEB_PHECODE204.12_GWAS-Catalog-r2019-05-03-X204.12_P_5e-08_UKB_20200608 204.12 Chronic lymphocytic leukemia Binary 66 unique SNPs UKB UK Biobank GWAS Hits GWAS Catalog (2019-05-03) 18758461;21131588;22700719;23770605;24292274;26956414;28165464 https://www.ncbi.nlm.nih.gov/pubmed/?term=18758461+21131588+22700719+23770605+24292274+26956414+28165464 32 4.6e-20 0.0997934 0.0795 0.675 0.64-0.707 OR 4.11 1.97-8.6 4.11 1.97-8.6 3.38 1.9-6.01 3.38 1.9-6.01 3.43 2.33-5.05 3.43 2.33-5.05 3.12 2.29-4.27 3.12 2.29-4.27 2.78 2.14-3.62 2.78 2.14-3.62 2.02 1.2-3.39 0.00779 3.07 1.88-5.02 8.09e-06 5.55 3.48-8.86 6.93e-13 TRUE FALSE FALSE TRUE Both 249 2509 GRCh37/hg19 P<=5e-08 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000647/ScoringFiles/ phewas/PRSWEB_PHECODE204.12_GWAS-Catalog-r2019-05-03-X204.12_P_5e-08_UKB_20200608/all.tsv phewas/PRSWEB_PHECODE204.12_GWAS-Catalog-r2019-05-03-X204.12_P_5e-08_UKB_20200608/exclusion.tsv 2020-06-08 prsweb-phecode204-12-gwas-catalog-r2019-05-03-x204-12-pt-ukb-20200608 prsweb-phecode204-12-gwas-catalog-r2019-05-03-x204-12-pt-ukb-20200608 PRSWEB_PHECODE204.12_GWAS-Catalog-r2019-05-03-X204.12_PT_UKB_20200608 P&T PRSWEB_PHECODE204.12_GWAS-Catalog-r2019-05-03-X204.12_PT_UKB_20200608 204.12 Chronic lymphocytic leukemia Binary 66 unique SNPs UKB UK Biobank P&T GWAS Catalog (2019-05-03) 18758461;21131588;22700719;23770605;24292274;26956414;28165464 https://www.ncbi.nlm.nih.gov/pubmed/?term=18758461+21131588+22700719+23770605+24292274+26956414+28165464 27 1.7e-19 0.102095 0.0796 0.672 0.637-0.703 OR 2.52 1.04-6.08 2.52 1.04-6.08 2.95 1.62-5.4 2.95 1.62-5.4 3.32 2.25-4.91 3.32 2.25-4.91 3.06 2.24-4.19 3.06 2.24-4.19 2.57 1.97-3.34 2.57 1.97-3.34 1.93 1.16-3.22 0.012 3.08 1.9-4.98 4.72e-06 5.08 3.2-8.05 4.83e-12 TRUE FALSE FALSE TRUE Both 249 2509 GRCh37/hg19 P<=2.51e-08 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000649/ScoringFiles/ phewas/PRSWEB_PHECODE204.12_GWAS-Catalog-r2019-05-03-X204.12_PT_UKB_20200608/all.tsv phewas/PRSWEB_PHECODE204.12_GWAS-Catalog-r2019-05-03-X204.12_PT_UKB_20200608/exclusion.tsv 2020-06-08 prsweb-phecode204-2-c-myeloid-leukaemia-p-5e-05-mgi-20200608 prsweb-phecode204-2-c-myeloid-leukaemia-p-5e-05-mgi-20200608 PRSWEB_PHECODE204.2_C-MYELOID-LEUKAEMIA_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE204.2_C-MYELOID-LEUKAEMIA_P_5e-05_MGI_20200608 204.2 Myeloid leukaemia Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 74 0.66 0.000327014 0.0826 0.497 0.443-0.553 OR 3.05 0.856-10.8 3.05 0.856-10.8 1.99 0.69-5.77 1.99 0.69-5.77 1.54 0.721-3.29 1.54 0.721-3.29 0.934 0.481-1.81 0.934 0.481-1.81 0.995 0.635-1.56 0.995 0.635-1.56 1.21 0.701-2.09 0.494 1.07 0.609-1.88 0.814 1.03 0.586-1.82 0.913 FALSE FALSE FALSE FALSE Both 109 1090 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode204-2-c-myeloid-leukaemia-p-5e-06-mgi-20200608 prsweb-phecode204-2-c-myeloid-leukaemia-p-5e-06-mgi-20200608 PRSWEB_PHECODE204.2_C-MYELOID-LEUKAEMIA_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE204.2_C-MYELOID-LEUKAEMIA_P_5e-06_MGI_20200608 204.2 Myeloid leukaemia Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 8 0.93 0.00766208 0.0826 0.5 0.445-0.549 OR 1.28 0.217-7.59 1.28 0.217-7.59 1.56 0.488-4.97 1.56 0.488-4.97 0.794 0.298-2.12 0.794 0.298-2.12 0.562 0.25-1.27 0.562 0.25-1.27 0.604 0.362-1.01 0.604 0.362-1.01 0.761 0.411-1.41 0.385 2.03 1.22-3.39 0.00634 0.761 0.41-1.41 0.385 FALSE FALSE FALSE FALSE Both 109 1090 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode204-2-c92-p-5e-06-mgi-20200608 prsweb-phecode204-2-c92-p-5e-06-mgi-20200608 PRSWEB_PHECODE204.2_C92_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE204.2_C92_P_5e-06_MGI_20200608 204.2 Diagnoses - main ICD10: C92 Myeloid leukaemia Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 9 0.45 0.00740633 0.0826 0.51 0.454-0.572 OR 3.04 0.866-10.7 3.04 0.866-10.7 1.54 0.481-4.95 1.54 0.481-4.95 1.35 0.612-2.98 1.35 0.612-2.98 1.68 0.974-2.9 1.68 0.974-2.9 1.25 0.814-1.92 1.25 0.814-1.92 0.788 0.446-1.39 0.413 0.94 0.546-1.62 0.825 1.06 0.625-1.78 0.84 FALSE FALSE FALSE FALSE Both 109 1090 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode204-2-c92-pt-mgi-20200608 prsweb-phecode204-2-c92-pt-mgi-20200608 PRSWEB_PHECODE204.2_C92_PT_MGI_20200608 P&T PRSWEB_PHECODE204.2_C92_PT_MGI_20200608 204.2 Diagnoses - main ICD10: C92 Myeloid leukaemia Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative P&T UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 8 0.4 0.0110299 0.0826 0.514 0.458-0.576 OR 0 0-0 0 0-0 1.53 0.478-4.9 1.53 0.478-4.9 1.55 0.732-3.29 1.55 0.732-3.29 1.14 0.616-2.12 1.14 0.616-2.12 1.42 0.932-2.16 1.42 0.932-2.16 1 0.569-1.77 0.99 0.925 0.52-1.65 0.791 1.34 0.789-2.29 0.276 FALSE FALSE FALSE FALSE Both 109 1090 GRCh37/hg19 P<=3.16e-06 2020-06-08 prsweb-phecode204-2-c-myeloid-leukaemia-prs-cs-mgi-20200608 prsweb-phecode204-2-c-myeloid-leukaemia-prs-cs-mgi-20200608 PRSWEB_PHECODE204.2_C-MYELOID-LEUKAEMIA_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE204.2_C-MYELOID-LEUKAEMIA_PRS-CS_MGI_20200608 204.2 Myeloid leukaemia Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative PRS-CS UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1034666 1 0.000349307 0.0826 0.505 0.448-0.557 OR 0 0-0 0 0-0 0.216 0.0126-3.69 0.216 0.0126-3.69 0.437 0.121-1.57 0.437 0.121-1.57 0.757 0.367-1.56 0.757 0.367-1.56 1.05 0.673-1.64 1.05 0.673-1.64 1.23 0.707-2.14 0.464 1.17 0.67-2.05 0.578 1.15 0.656-2 0.632 FALSE FALSE FALSE FALSE Both 109 1090 GRCh37/hg19 auto 2020-06-08 prsweb-phecode204-21-ukbb-saige-hrc-x204-21-pt-mgi-20200608 prsweb-phecode204-21-ukbb-saige-hrc-x204-21-pt-mgi-20200608 PRSWEB_PHECODE204.21_UKBB-SAIGE-HRC-X204.21_PT_MGI_20200608 P&T PRSWEB_PHECODE204.21_UKBB-SAIGE-HRC-X204.21_PT_MGI_20200608 204.21 Myeloid leukemia, acute Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative P&T UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 23 0.96 0.014772 0.0826 0.487 0.415-0.554 OR 0 0-0 0 0-0 2.68 0.765-9.4 2.68 0.765-9.4 1.09 0.35-3.41 1.09 0.35-3.41 0.845 0.341-2.09 0.845 0.341-2.09 0.891 0.485-1.64 0.891 0.485-1.64 1.02 0.488-2.14 0.955 1.29 0.641-2.59 0.476 0.836 0.393-1.78 0.641 FALSE FALSE FALSE FALSE Both 62 620 GRCh37/hg19 P<=1.26e-05 2020-06-08 prsweb-phecode204-21-ukbb-saige-hrc-x204-21-lassosum-mgi-20200608 prsweb-phecode204-21-ukbb-saige-hrc-x204-21-lassosum-mgi-20200608 PRSWEB_PHECODE204.21_UKBB-SAIGE-HRC-X204.21_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE204.21_UKBB-SAIGE-HRC-X204.21_LASSOSUM_MGI_20200608 204.21 Myeloid leukemia, acute Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative lassosum UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 40976 0.96 0.0147375 0.0826 0.502 0.431-0.565 OR 1.89 0.292-12.3 1.89 0.292-12.3 1.07 0.187-6.16 1.07 0.187-6.16 0.442 0.0848-2.31 0.442 0.0848-2.31 0.518 0.173-1.55 0.518 0.173-1.55 0.668 0.347-1.29 0.668 0.347-1.29 1.33 0.615-2.87 0.468 2.2 1.06-4.53 0.0332 1.01 0.448-2.28 0.978 FALSE FALSE FALSE FALSE Both 62 620 GRCh37/hg19 s=0.2;Lambda=0.06158 2020-06-08 prsweb-phecode204-22-ukbb-saige-hrc-x204-22-p-5e-05-mgi-20200608 prsweb-phecode204-22-ukbb-saige-hrc-x204-22-p-5e-05-mgi-20200608 PRSWEB_PHECODE204.22_UKBB-SAIGE-HRC-X204.22_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE204.22_UKBB-SAIGE-HRC-X204.22_P_5e-05_MGI_20200608 204.22 Myeloid leukemia, chronic Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 72 0.49 0.00617516 0.0825 0.53 0.423-0.642 OR 4.48 0.473-42.5 4.48 0.473-42.5 2.35 0.341-16.2 2.35 0.341-16.2 1.68 0.409-6.89 1.68 0.409-6.89 1.16 0.358-3.73 1.16 0.358-3.73 1.79 0.83-3.86 1.79 0.83-3.86 1.88 0.648-5.44 0.246 0.767 0.232-2.53 0.664 2.2 0.775-6.23 0.139 FALSE FALSE FALSE FALSE Both 30 300 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode204-22-ukbb-saige-hrc-x204-22-p-5e-06-mgi-20200608 prsweb-phecode204-22-ukbb-saige-hrc-x204-22-p-5e-06-mgi-20200608 PRSWEB_PHECODE204.22_UKBB-SAIGE-HRC-X204.22_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE204.22_UKBB-SAIGE-HRC-X204.22_P_5e-06_MGI_20200608 204.22 Myeloid leukemia, chronic Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 9 0.062 0.00596889 0.0818 0.552 0.443-0.671 OR 4.32 0.481-38.8 4.32 0.481-38.8 3.83 0.772-19 3.83 0.772-19 3.09 0.983-9.71 3.09 0.983-9.71 1.51 0.522-4.35 1.51 0.522-4.35 1.53 0.708-3.32 1.53 0.708-3.32 1.26 0.413-3.86 0.681 1.72 0.607-4.88 0.307 2.11 0.742-6.02 0.161 FALSE FALSE FALSE FALSE Both 30 300 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode204-22-ukbb-saige-hrc-x204-22-pt-mgi-20200608 prsweb-phecode204-22-ukbb-saige-hrc-x204-22-pt-mgi-20200608 PRSWEB_PHECODE204.22_UKBB-SAIGE-HRC-X204.22_PT_MGI_20200608 P&T PRSWEB_PHECODE204.22_UKBB-SAIGE-HRC-X204.22_PT_MGI_20200608 204.22 Myeloid leukemia, chronic Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative P&T UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 62 0.39 0.0247243 0.0825 0.538 0.433-0.645 OR 4.58 0.489-42.8 4.58 0.489-42.8 2.34 0.338-16.2 2.34 0.338-16.2 1.68 0.405-6.93 1.68 0.405-6.93 0.796 0.211-3 0.796 0.211-3 1.78 0.821-3.84 1.78 0.821-3.84 1.36 0.452-4.11 0.583 1.4 0.463-4.25 0.55 2.14 0.763-6.01 0.148 FALSE FALSE FALSE FALSE Both 30 300 GRCh37/hg19 P<=3.98e-05 2020-06-08 prsweb-phecode204-4-c-multiple-myeloma-plasma-cell-p-5e-05-mgi-20200608 prsweb-phecode204-4-c-multiple-myeloma-plasma-cell-p-5e-05-mgi-20200608 PRSWEB_PHECODE204.4_C-MULTIPLE-MYELOMA-PLASMA-CELL_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE204.4_C-MULTIPLE-MYELOMA-PLASMA-CELL_P_5e-05_MGI_20200608 204.4 Multiple myeloma and malignant plasma cell neoplasms Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 85 0.11 0.0002392 0.0825 0.548 0.481-0.609 OR 0 0-0 0 0-0 0.802 0.143-4.49 0.802 0.143-4.49 1.03 0.376-2.83 1.03 0.376-2.83 1.74 0.93-3.26 1.74 0.93-3.26 1.52 0.946-2.46 1.52 0.946-2.46 1.44 0.744-2.8 0.277 0.889 0.439-1.8 0.744 1.74 0.927-3.26 0.0846 FALSE FALSE FALSE FALSE Both 83 825 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode204-4-c90-p-5e-05-mgi-20200608 prsweb-phecode204-4-c90-p-5e-05-mgi-20200608 PRSWEB_PHECODE204.4_C90_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE204.4_C90_P_5e-05_MGI_20200608 204.4 Diagnoses - main ICD10: C90 Multiple myeloma and malignant plasma cell neoplasms Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 107 0.21 0.000125465 0.0826 0.535 0.475-0.598 OR 2.69 0.615-11.7 2.69 0.615-11.7 1.51 0.381-5.97 1.51 0.381-5.97 1.63 0.686-3.85 1.63 0.686-3.85 1.18 0.581-2.41 1.18 0.581-2.41 1.17 0.707-1.92 1.17 0.707-1.92 1.39 0.714-2.7 0.334 1.52 0.786-2.94 0.214 1.49 0.765-2.91 0.241 FALSE FALSE FALSE FALSE Both 83 825 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode204-4-gwas-catalog-r2019-05-03-x204-4-p-5e-05-mgi-20200608 prsweb-phecode204-4-gwas-catalog-r2019-05-03-x204-4-p-5e-05-mgi-20200608 PRSWEB_PHECODE204.4_GWAS-Catalog-r2019-05-03-X204.4_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE204.4_GWAS-Catalog-r2019-05-03-X204.4_P_5e-05_MGI_20200608 204.4 Multiple myeloma (hyperdiploidy);Multiple myeloma (IgH translocation);Multiple myeloma;Multiple myeloma and monoclonal gammopathy Binary 70 unique SNPs MGI Michigan Genomics Initiative Fixed threshold (5e-05) GWAS Catalog (2019-05-03) 22120009;23502783;23955597;26007630;27363682;30213928 https://www.ncbi.nlm.nih.gov/pubmed/?term=22120009+23502783+23955597+26007630+27363682+30213928 54 0.54 0.0108481 0.0827 0.509 0.436-0.58 OR 1.23 0.194-7.84 1.23 0.194-7.84 2.27 0.753-6.85 2.27 0.753-6.85 1.96 0.894-4.28 1.96 0.894-4.28 1.5 0.787-2.85 1.5 0.787-2.85 1.27 0.776-2.08 1.27 0.776-2.08 0.358 0.172-0.743 0.00581 0.75 0.414-1.36 0.342 0.883 0.496-1.57 0.671 FALSE FALSE FALSE FALSE Both 83 825 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode204-4-20001-1050-p-5e-06-mgi-20200608 prsweb-phecode204-4-20001-1050-p-5e-06-mgi-20200608 PRSWEB_PHECODE204.4_20001-1050_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE204.4_20001-1050_P_5e-06_MGI_20200608 204.4 Cancer code, self-reported: multiple myeloma Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 5 0.099 0.00511081 0.0824 0.539 0.467-0.61 OR 2.28 0.515-10.1 2.28 0.515-10.1 1.33 0.335-5.26 1.33 0.335-5.26 1.49 0.627-3.53 1.49 0.627-3.53 1.33 0.679-2.59 1.33 0.679-2.59 1.27 0.776-2.06 1.27 0.776-2.06 0.744 0.37-1.49 0.405 1.23 0.667-2.28 0.502 1.28 0.688-2.37 0.438 FALSE FALSE FALSE FALSE Both 83 825 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode204-4-c-multiple-myeloma-plasma-cell-p-5e-06-mgi-20200608 prsweb-phecode204-4-c-multiple-myeloma-plasma-cell-p-5e-06-mgi-20200608 PRSWEB_PHECODE204.4_C-MULTIPLE-MYELOMA-PLASMA-CELL_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE204.4_C-MULTIPLE-MYELOMA-PLASMA-CELL_P_5e-06_MGI_20200608 204.4 Multiple myeloma and malignant plasma cell neoplasms Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 11 0.028 0.000659298 0.0822 0.559 0.498-0.617 OR 2.61 0.598-11.4 2.61 0.598-11.4 1.42 0.359-5.6 1.42 0.359-5.6 1.34 0.533-3.39 1.34 0.533-3.39 1.43 0.736-2.78 1.43 0.736-2.78 1.54 0.954-2.47 1.54 0.954-2.47 0.792 0.385-1.63 0.525 1.41 0.748-2.65 0.289 1.6 0.865-2.95 0.134 TRUE FALSE FALSE FALSE Both 83 825 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode204-4-c90-p-5e-06-mgi-20200608 prsweb-phecode204-4-c90-p-5e-06-mgi-20200608 PRSWEB_PHECODE204.4_C90_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE204.4_C90_P_5e-06_MGI_20200608 204.4 Diagnoses - main ICD10: C90 Multiple myeloma and malignant plasma cell neoplasms Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 19 0.17 0.000368938 0.0826 0.534 0.469-0.598 OR 1.52 0.247-9.34 1.52 0.247-9.34 1.4 0.356-5.53 1.4 0.356-5.53 1.3 0.518-3.27 1.3 0.518-3.27 1.39 0.718-2.69 1.39 0.718-2.69 1.35 0.835-2.2 1.35 0.835-2.2 0.84 0.416-1.7 0.628 1.39 0.747-2.6 0.298 1.47 0.792-2.73 0.222 FALSE FALSE FALSE FALSE Both 83 825 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode204-4-gwas-catalog-r2019-05-03-x204-4-p-5e-06-mgi-20200608 prsweb-phecode204-4-gwas-catalog-r2019-05-03-x204-4-p-5e-06-mgi-20200608 PRSWEB_PHECODE204.4_GWAS-Catalog-r2019-05-03-X204.4_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE204.4_GWAS-Catalog-r2019-05-03-X204.4_P_5e-06_MGI_20200608 204.4 Multiple myeloma (hyperdiploidy);Multiple myeloma (IgH translocation);Multiple myeloma;Multiple myeloma and monoclonal gammopathy Binary 70 unique SNPs MGI Michigan Genomics Initiative Fixed threshold (5e-06) GWAS Catalog (2019-05-03) 22120009;23502783;23955597;26007630;27363682;30213928 https://www.ncbi.nlm.nih.gov/pubmed/?term=22120009+23502783+23955597+26007630+27363682+30213928 45 0.51 0.0241372 0.0827 0.516 0.443-0.583 OR 0 0-0 0 0-0 0.232 0.0135-4 0.232 0.0135-4 1.2 0.474-3.02 1.2 0.474-3.02 1.45 0.757-2.77 1.45 0.757-2.77 1.35 0.83-2.18 1.35 0.83-2.18 0.568 0.29-1.11 0.099 0.778 0.419-1.44 0.425 1.09 0.612-1.95 0.764 FALSE FALSE FALSE FALSE Both 83 825 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode204-4-ukbb-saige-hrc-x204-4-p-5e-06-mgi-20200608 prsweb-phecode204-4-ukbb-saige-hrc-x204-4-p-5e-06-mgi-20200608 PRSWEB_PHECODE204.4_UKBB-SAIGE-HRC-X204.4_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE204.4_UKBB-SAIGE-HRC-X204.4_P_5e-06_MGI_20200608 204.4 Multiple myeloma Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 10 0.81 0.00459676 0.0827 0.499 0.439-0.56 OR 0 0-0 0 0-0 0.278 0.016-4.85 0.278 0.016-4.85 0.785 0.257-2.39 0.785 0.257-2.39 0.635 0.261-1.54 0.635 0.261-1.54 1.03 0.616-1.73 1.03 0.616-1.73 0.793 0.414-1.52 0.483 1.19 0.646-2.18 0.583 0.977 0.521-1.83 0.943 FALSE FALSE FALSE FALSE Both 83 825 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode204-4-gwas-catalog-r2019-05-03-x204-4-p-5e-07-mgi-20200608 prsweb-phecode204-4-gwas-catalog-r2019-05-03-x204-4-p-5e-07-mgi-20200608 PRSWEB_PHECODE204.4_GWAS-Catalog-r2019-05-03-X204.4_P_5e-07_MGI_20200608 P_5e-07 PRSWEB_PHECODE204.4_GWAS-Catalog-r2019-05-03-X204.4_P_5e-07_MGI_20200608 204.4 Multiple myeloma (hyperdiploidy);Multiple myeloma (IgH translocation);Multiple myeloma;Multiple myeloma and monoclonal gammopathy Binary 70 unique SNPs MGI Michigan Genomics Initiative Fixed threshold (5e-07) GWAS Catalog (2019-05-03) 22120009;23502783;23955597;26007630;27363682;30213928 https://www.ncbi.nlm.nih.gov/pubmed/?term=22120009+23502783+23955597+26007630+27363682+30213928 28 0.28 0.0135146 0.0826 0.519 0.453-0.583 OR 3.79 1.01-14.2 3.79 1.01-14.2 2.69 0.892-8.13 2.69 0.892-8.13 2.09 0.949-4.59 2.09 0.949-4.59 1.5 0.789-2.86 1.5 0.789-2.86 1.39 0.853-2.25 1.39 0.853-2.25 1.05 0.569-1.95 0.869 0.665 0.336-1.31 0.241 1.27 0.696-2.31 0.44 FALSE FALSE FALSE FALSE Both 83 825 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode204-4-gwas-catalog-r2019-05-03-x204-4-p-5e-09-mgi-20200608 prsweb-phecode204-4-gwas-catalog-r2019-05-03-x204-4-p-5e-09-mgi-20200608 PRSWEB_PHECODE204.4_GWAS-Catalog-r2019-05-03-X204.4_P_5e-09_MGI_20200608 P_5e-09 PRSWEB_PHECODE204.4_GWAS-Catalog-r2019-05-03-X204.4_P_5e-09_MGI_20200608 204.4 Multiple myeloma (hyperdiploidy);Multiple myeloma (IgH translocation);Multiple myeloma;Multiple myeloma and monoclonal gammopathy Binary 70 unique SNPs MGI Michigan Genomics Initiative Fixed threshold (5e-09) GWAS Catalog (2019-05-03) 22120009;23502783;23955597;26007630;27363682;30213928 https://www.ncbi.nlm.nih.gov/pubmed/?term=22120009+23502783+23955597+26007630+27363682+30213928 15 0.31 0.0059964 0.0826 0.524 0.46-0.584 OR 3.7 1-13.6 3.7 1-13.6 3.25 1.17-9.02 3.25 1.17-9.02 1.25 0.496-3.15 1.25 0.496-3.15 0.857 0.392-1.87 0.857 0.392-1.87 1.26 0.766-2.06 1.26 0.766-2.06 1.49 0.792-2.81 0.215 0.972 0.492-1.92 0.935 1.45 0.763-2.74 0.258 FALSE FALSE FALSE FALSE Both 83 825 GRCh37/hg19 P<=5e-09 2020-06-08 prsweb-phecode204-4-gwas-catalog-r2019-05-03-x204-4-p-5e-08-mgi-20200608 prsweb-phecode204-4-gwas-catalog-r2019-05-03-x204-4-p-5e-08-mgi-20200608 PRSWEB_PHECODE204.4_GWAS-Catalog-r2019-05-03-X204.4_P_5e-08_MGI_20200608 P_5e-08 PRSWEB_PHECODE204.4_GWAS-Catalog-r2019-05-03-X204.4_P_5e-08_MGI_20200608 204.4 Multiple myeloma (hyperdiploidy);Multiple myeloma (IgH translocation);Multiple myeloma;Multiple myeloma and monoclonal gammopathy Binary 70 unique SNPs MGI Michigan Genomics Initiative GWAS Hits GWAS Catalog (2019-05-03) 22120009;23502783;23955597;26007630;27363682;30213928 https://www.ncbi.nlm.nih.gov/pubmed/?term=22120009+23502783+23955597+26007630+27363682+30213928 22 0.15 0.00813378 0.0826 0.536 0.473-0.598 OR 4.92 1.48-16.4 4.92 1.48-16.4 3.32 1.2-9.21 3.32 1.2-9.21 1.75 0.768-3.97 1.75 0.768-3.97 1.28 0.645-2.54 1.28 0.645-2.54 1.17 0.709-1.92 1.17 0.709-1.92 1.4 0.718-2.74 0.323 1.65 0.848-3.21 0.141 1.62 0.835-3.14 0.154 FALSE FALSE FALSE FALSE Both 83 825 GRCh37/hg19 P<=5e-08 2020-06-08 prsweb-phecode204-4-c-multiple-myeloma-plasma-cell-pt-mgi-20200608 prsweb-phecode204-4-c-multiple-myeloma-plasma-cell-pt-mgi-20200608 PRSWEB_PHECODE204.4_C-MULTIPLE-MYELOMA-PLASMA-CELL_PT_MGI_20200608 P&T PRSWEB_PHECODE204.4_C-MULTIPLE-MYELOMA-PLASMA-CELL_PT_MGI_20200608 204.4 Multiple myeloma and malignant plasma cell neoplasms Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative P&T UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 32 0.24 0.00188238 0.0826 0.523 0.461-0.587 OR 0 0-0 0 0-0 2.07 0.626-6.82 2.07 0.626-6.82 1.83 0.81-4.14 1.83 0.81-4.14 1.41 0.724-2.73 1.41 0.724-2.73 1.09 0.661-1.81 1.09 0.661-1.81 1.11 0.579-2.12 0.758 1.27 0.671-2.4 0.464 1.18 0.629-2.22 0.604 FALSE FALSE FALSE FALSE Both 83 825 GRCh37/hg19 P<=1.58e-05 2020-06-08 prsweb-phecode204-4-c90-pt-mgi-20200608 prsweb-phecode204-4-c90-pt-mgi-20200608 PRSWEB_PHECODE204.4_C90_PT_MGI_20200608 P&T PRSWEB_PHECODE204.4_C90_PT_MGI_20200608 204.4 Diagnoses - main ICD10: C90 Multiple myeloma and malignant plasma cell neoplasms Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative P&T UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 27 0.044 0.0013006 0.0823 0.547 0.479-0.613 OR 2.6 0.593-11.4 2.6 0.593-11.4 1.95 0.588-6.45 1.95 0.588-6.45 1.49 0.631-3.53 1.49 0.631-3.53 1.52 0.8-2.88 1.52 0.8-2.88 1.77 1.11-2.83 1.77 1.11-2.83 1.16 0.593-2.26 0.668 0.965 0.487-1.91 0.919 1.83 0.996-3.37 0.0516 TRUE FALSE FALSE TRUE Both 83 825 GRCh37/hg19 P<=7.94e-06 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000652/ScoringFiles/ phewas/PRSWEB_PHECODE204.4_C90_PT_MGI_20200608/all.tsv phewas/PRSWEB_PHECODE204.4_C90_PT_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode204-4-gwas-catalog-r2019-05-03-x204-4-pt-mgi-20200608 prsweb-phecode204-4-gwas-catalog-r2019-05-03-x204-4-pt-mgi-20200608 PRSWEB_PHECODE204.4_GWAS-Catalog-r2019-05-03-X204.4_PT_MGI_20200608 P&T PRSWEB_PHECODE204.4_GWAS-Catalog-r2019-05-03-X204.4_PT_MGI_20200608 204.4 Multiple myeloma (hyperdiploidy);Multiple myeloma (IgH translocation);Multiple myeloma;Multiple myeloma and monoclonal gammopathy Binary 70 unique SNPs MGI Michigan Genomics Initiative P&T GWAS Catalog (2019-05-03) 22120009;23502783;23955597;26007630;27363682;30213928 https://www.ncbi.nlm.nih.gov/pubmed/?term=22120009+23502783+23955597+26007630+27363682+30213928 45 0.51 0.0241372 0.0827 0.516 0.443-0.583 OR 0 0-0 0 0-0 0.232 0.0135-4 0.232 0.0135-4 1.2 0.474-3.02 1.2 0.474-3.02 1.45 0.757-2.77 1.45 0.757-2.77 1.35 0.83-2.18 1.35 0.83-2.18 0.568 0.29-1.11 0.099 0.778 0.419-1.44 0.425 1.09 0.612-1.95 0.764 FALSE FALSE FALSE FALSE Both 83 825 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode204-4-ukbb-saige-hrc-x204-4-pt-mgi-20200608 prsweb-phecode204-4-ukbb-saige-hrc-x204-4-pt-mgi-20200608 PRSWEB_PHECODE204.4_UKBB-SAIGE-HRC-X204.4_PT_MGI_20200608 P&T PRSWEB_PHECODE204.4_UKBB-SAIGE-HRC-X204.4_PT_MGI_20200608 204.4 Multiple myeloma Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative P&T UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 10 0.81 0.00459676 0.0827 0.499 0.439-0.56 OR 0 0-0 0 0-0 0.278 0.016-4.85 0.278 0.016-4.85 0.785 0.257-2.39 0.785 0.257-2.39 0.635 0.261-1.54 0.635 0.261-1.54 1.03 0.616-1.73 1.03 0.616-1.73 0.793 0.414-1.52 0.483 1.19 0.646-2.18 0.583 0.977 0.521-1.83 0.943 FALSE FALSE FALSE FALSE Both 83 825 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode204-4-20001-1050-prs-cs-mgi-20200608 prsweb-phecode204-4-20001-1050-prs-cs-mgi-20200608 PRSWEB_PHECODE204.4_20001-1050_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE204.4_20001-1050_PRS-CS_MGI_20200608 204.4 Cancer code, self-reported: multiple myeloma Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative PRS-CS UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 872863 0.54 0.00213323 0.0827 0.513 0.448-0.579 OR 0 0-0 0 0-0 1.84 0.555-6.11 1.84 0.555-6.11 1.28 0.508-3.2 1.28 0.508-3.2 1.56 0.822-2.96 1.56 0.822-2.96 1.16 0.706-1.91 1.16 0.706-1.91 0.938 0.5-1.76 0.841 0.957 0.506-1.81 0.892 1.09 0.596-2 0.776 FALSE FALSE FALSE FALSE Both 83 825 GRCh37/hg19 auto 2020-06-08 prsweb-phecode204-4-c-multiple-myeloma-plasma-cell-prs-cs-mgi-20200608 prsweb-phecode204-4-c-multiple-myeloma-plasma-cell-prs-cs-mgi-20200608 PRSWEB_PHECODE204.4_C-MULTIPLE-MYELOMA-PLASMA-CELL_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE204.4_C-MULTIPLE-MYELOMA-PLASMA-CELL_PRS-CS_MGI_20200608 204.4 Multiple myeloma and malignant plasma cell neoplasms Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative PRS-CS UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1060905 0.42 0.000595922 0.0827 0.531 0.47-0.596 OR 1.5 0.243-9.19 1.5 0.243-9.19 1.44 0.363-5.7 1.44 0.363-5.7 1.26 0.501-3.16 1.26 0.501-3.16 1.25 0.633-2.47 1.25 0.633-2.47 0.901 0.533-1.52 0.901 0.533-1.52 1.03 0.528-1.99 0.94 1.52 0.82-2.81 0.184 1.07 0.556-2.06 0.841 FALSE FALSE FALSE FALSE Both 83 825 GRCh37/hg19 auto 2020-06-08 prsweb-phecode204-4-c90-prs-cs-mgi-20200608 prsweb-phecode204-4-c90-prs-cs-mgi-20200608 PRSWEB_PHECODE204.4_C90_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE204.4_C90_PRS-CS_MGI_20200608 204.4 Diagnoses - main ICD10: C90 Multiple myeloma and malignant plasma cell neoplasms Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative PRS-CS UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1064537 0.15 0.000154242 0.0826 0.554 0.489-0.616 OR 2.51 0.571-11 2.51 0.571-11 1.4 0.354-5.51 1.4 0.354-5.51 1.22 0.482-3.08 1.22 0.482-3.08 1.06 0.522-2.17 1.06 0.522-2.17 1.4 0.866-2.28 1.4 0.866-2.28 1.81 0.894-3.65 0.0991 1.49 0.742-2.97 0.263 2.01 1.03-3.92 0.0409 FALSE FALSE FALSE FALSE Both 83 825 GRCh37/hg19 auto 2020-06-08 prsweb-phecode204-4-ukbb-saige-hrc-x204-4-prs-cs-mgi-20200608 prsweb-phecode204-4-ukbb-saige-hrc-x204-4-prs-cs-mgi-20200608 PRSWEB_PHECODE204.4_UKBB-SAIGE-HRC-X204.4_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE204.4_UKBB-SAIGE-HRC-X204.4_PRS-CS_MGI_20200608 204.4 Multiple myeloma Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative PRS-CS UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1119238 0.43 4.09017e-05 0.0827 0.532 0.467-0.599 OR 1.52 0.25-9.32 1.52 0.25-9.32 1.33 0.337-5.24 1.33 0.337-5.24 0.997 0.367-2.71 0.997 0.367-2.71 1.09 0.537-2.22 1.09 0.537-2.22 1.28 0.786-2.08 1.28 0.786-2.08 1.31 0.679-2.51 0.423 1.28 0.653-2.53 0.468 1.47 0.771-2.79 0.243 FALSE FALSE FALSE FALSE Both 83 825 GRCh37/hg19 auto 2020-06-08 prsweb-phecode204-4-20001-1050-lassosum-mgi-20200608 prsweb-phecode204-4-20001-1050-lassosum-mgi-20200608 PRSWEB_PHECODE204.4_20001-1050_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE204.4_20001-1050_LASSOSUM_MGI_20200608 204.4 Cancer code, self-reported: multiple myeloma Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative lassosum UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 37583 0.69 0.000952588 0.0827 0.518 0.455-0.578 OR 0 0-0 0 0-0 0.864 0.158-4.74 0.864 0.158-4.74 0.815 0.268-2.48 0.815 0.268-2.48 0.747 0.327-1.7 0.747 0.327-1.7 1.09 0.66-1.81 1.09 0.66-1.81 1.13 0.585-2.19 0.714 1.4 0.743-2.62 0.301 1.2 0.637-2.27 0.57 FALSE FALSE FALSE FALSE Both 83 825 GRCh37/hg19 s=0.2;Lambda=0.07848 2020-06-08 prsweb-phecode204-4-c-multiple-myeloma-plasma-cell-lassosum-mgi-20200608 prsweb-phecode204-4-c-multiple-myeloma-plasma-cell-lassosum-mgi-20200608 PRSWEB_PHECODE204.4_C-MULTIPLE-MYELOMA-PLASMA-CELL_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE204.4_C-MULTIPLE-MYELOMA-PLASMA-CELL_LASSOSUM_MGI_20200608 204.4 Multiple myeloma and malignant plasma cell neoplasms Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative lassosum UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 31983 0.17 0.00597942 0.0826 0.544 0.477-0.618 OR 1.55 0.252-9.5 1.55 0.252-9.5 0.732 0.131-4.08 0.732 0.131-4.08 1.77 0.783-4 1.77 0.783-4 1.7 0.915-3.18 1.7 0.915-3.18 1.51 0.936-2.43 1.51 0.936-2.43 1.13 0.58-2.21 0.715 1.05 0.539-2.05 0.882 1.73 0.928-3.24 0.0842 FALSE FALSE FALSE FALSE Both 83 825 GRCh37/hg19 s=0.9;Lambda=0.06158 2020-06-08 prsweb-phecode204-4-c90-lassosum-mgi-20200608 prsweb-phecode204-4-c90-lassosum-mgi-20200608 PRSWEB_PHECODE204.4_C90_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE204.4_C90_LASSOSUM_MGI_20200608 204.4 Diagnoses - main ICD10: C90 Multiple myeloma and malignant plasma cell neoplasms Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative lassosum UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 68757 0.7 0.00253686 0.0827 0.501 0.432-0.581 OR 3.83 1.04-14.1 3.83 1.04-14.1 3.19 1.16-8.77 3.19 1.16-8.77 2.46 1.16-5.2 2.46 1.16-5.2 2.16 1.2-3.86 2.16 1.2-3.86 1.36 0.84-2.21 1.36 0.84-2.21 0.734 0.388-1.39 0.341 0.61 0.317-1.17 0.137 1.03 0.576-1.83 0.932 FALSE FALSE FALSE FALSE Both 83 825 GRCh37/hg19 s=1;Lambda=0.06158 2020-06-08 prsweb-phecode204-4-ukbb-saige-hrc-x204-4-lassosum-mgi-20200608 prsweb-phecode204-4-ukbb-saige-hrc-x204-4-lassosum-mgi-20200608 PRSWEB_PHECODE204.4_UKBB-SAIGE-HRC-X204.4_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE204.4_UKBB-SAIGE-HRC-X204.4_LASSOSUM_MGI_20200608 204.4 Multiple myeloma Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative lassosum UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 614225 0.27 0.00481423 0.0826 0.539 0.473-0.603 OR 1.52 0.247-9.42 1.52 0.247-9.42 1.35 0.342-5.34 1.35 0.342-5.34 1.23 0.491-3.1 1.23 0.491-3.1 1.12 0.55-2.27 1.12 0.55-2.27 1.17 0.714-1.93 1.17 0.714-1.93 0.864 0.435-1.71 0.676 1.38 0.744-2.55 0.308 1.28 0.685-2.4 0.436 FALSE FALSE FALSE FALSE Both 83 825 GRCh37/hg19 s=0.2;Lambda=0.01438 2020-06-08 prsweb-phecode204-4-gwas-catalog-r2019-05-03-x204-4-p-5e-05-ukb-20200608 prsweb-phecode204-4-gwas-catalog-r2019-05-03-x204-4-p-5e-05-ukb-20200608 PRSWEB_PHECODE204.4_GWAS-Catalog-r2019-05-03-X204.4_P_5e-05_UKB_20200608 P_5e-05 PRSWEB_PHECODE204.4_GWAS-Catalog-r2019-05-03-X204.4_P_5e-05_UKB_20200608 204.4 Multiple myeloma (hyperdiploidy);Multiple myeloma (IgH translocation);Multiple myeloma;Multiple myeloma and monoclonal gammopathy Binary 70 unique SNPs UKB UK Biobank Fixed threshold (5e-05) GWAS Catalog (2019-05-03) 22120009;23502783;23955597;26007630;27363682;30213928 https://www.ncbi.nlm.nih.gov/pubmed/?term=22120009+23502783+23955597+26007630+27363682+30213928 54 0.12 0.00635651 0.0823 0.521 0.483-0.562 OR 2.18 0.848-5.6 2.18 0.848-5.6 1.71 0.812-3.59 1.71 0.812-3.59 1.51 0.912-2.51 1.51 0.912-2.51 1.59 1.1-2.31 1.59 1.1-2.31 1.14 0.849-1.52 1.14 0.849-1.52 0.924 0.633-1.35 0.685 1.12 0.778-1.61 0.544 1.13 0.788-1.63 0.503 FALSE FALSE FALSE FALSE Both 248 2490 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode204-4-gwas-catalog-r2019-05-03-x204-4-p-5e-06-ukb-20200608 prsweb-phecode204-4-gwas-catalog-r2019-05-03-x204-4-p-5e-06-ukb-20200608 PRSWEB_PHECODE204.4_GWAS-Catalog-r2019-05-03-X204.4_P_5e-06_UKB_20200608 P_5e-06 PRSWEB_PHECODE204.4_GWAS-Catalog-r2019-05-03-X204.4_P_5e-06_UKB_20200608 204.4 Multiple myeloma (hyperdiploidy);Multiple myeloma (IgH translocation);Multiple myeloma;Multiple myeloma and monoclonal gammopathy Binary 70 unique SNPs UKB UK Biobank Fixed threshold (5e-06) GWAS Catalog (2019-05-03) 22120009;23502783;23955597;26007630;27363682;30213928 https://www.ncbi.nlm.nih.gov/pubmed/?term=22120009+23502783+23955597+26007630+27363682+30213928 45 0.002 0.0110867 0.0821 0.554 0.515-0.595 OR 3 1.3-6.93 3 1.3-6.93 1.92 0.943-3.91 1.92 0.943-3.91 1.16 0.665-2.04 1.16 0.665-2.04 1.45 0.986-2.12 1.45 0.986-2.12 1.71 1.3-2.24 1.71 1.3-2.24 1.26 0.856-1.85 0.242 0.952 0.632-1.43 0.812 1.81 1.26-2.59 0.00134 TRUE FALSE FALSE FALSE Both 248 2490 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode204-4-gwas-catalog-r2019-05-03-x204-4-p-5e-07-ukb-20200608 prsweb-phecode204-4-gwas-catalog-r2019-05-03-x204-4-p-5e-07-ukb-20200608 PRSWEB_PHECODE204.4_GWAS-Catalog-r2019-05-03-X204.4_P_5e-07_UKB_20200608 P_5e-07 PRSWEB_PHECODE204.4_GWAS-Catalog-r2019-05-03-X204.4_P_5e-07_UKB_20200608 204.4 Multiple myeloma (hyperdiploidy);Multiple myeloma (IgH translocation);Multiple myeloma;Multiple myeloma and monoclonal gammopathy Binary 70 unique SNPs UKB UK Biobank Fixed threshold (5e-07) GWAS Catalog (2019-05-03) 22120009;23502783;23955597;26007630;27363682;30213928 https://www.ncbi.nlm.nih.gov/pubmed/?term=22120009+23502783+23955597+26007630+27363682+30213928 28 8.8e-05 0.0217727 0.0819 0.573 0.532-0.611 OR 1.78 0.639-4.98 1.78 0.639-4.98 1.72 0.815-3.61 1.72 0.815-3.61 1.79 1.11-2.88 1.79 1.11-2.88 2.17 1.55-3.05 2.17 1.55-3.05 1.56 1.19-2.06 1.56 1.19-2.06 1.31 0.873-1.97 0.193 1.46 0.984-2.18 0.0601 1.98 1.35-2.89 0.000436 TRUE FALSE FALSE FALSE Both 248 2490 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode204-4-gwas-catalog-r2019-05-03-x204-4-p-5e-09-ukb-20200608 prsweb-phecode204-4-gwas-catalog-r2019-05-03-x204-4-p-5e-09-ukb-20200608 PRSWEB_PHECODE204.4_GWAS-Catalog-r2019-05-03-X204.4_P_5e-09_UKB_20200608 P_5e-09 PRSWEB_PHECODE204.4_GWAS-Catalog-r2019-05-03-X204.4_P_5e-09_UKB_20200608 204.4 Multiple myeloma (hyperdiploidy);Multiple myeloma (IgH translocation);Multiple myeloma;Multiple myeloma and monoclonal gammopathy Binary 70 unique SNPs UKB UK Biobank Fixed threshold (5e-09) GWAS Catalog (2019-05-03) 22120009;23502783;23955597;26007630;27363682;30213928 https://www.ncbi.nlm.nih.gov/pubmed/?term=22120009+23502783+23955597+26007630+27363682+30213928 15 0.00012 0.0222079 0.0819 0.571 0.532-0.61 OR 2.61 1.08-6.33 2.61 1.08-6.33 2.57 1.36-4.86 2.57 1.36-4.86 1.52 0.914-2.52 1.52 0.914-2.52 1.6 1.1-2.31 1.6 1.1-2.31 1.43 1.08-1.89 1.43 1.08-1.89 1.3 0.866-1.95 0.207 1.55 1.05-2.28 0.0289 1.78 1.22-2.61 0.00289 TRUE FALSE FALSE FALSE Both 248 2490 GRCh37/hg19 P<=5e-09 2020-06-08 prsweb-phecode204-4-gwas-catalog-r2019-05-03-x204-4-p-5e-08-ukb-20200608 prsweb-phecode204-4-gwas-catalog-r2019-05-03-x204-4-p-5e-08-ukb-20200608 PRSWEB_PHECODE204.4_GWAS-Catalog-r2019-05-03-X204.4_P_5e-08_UKB_20200608 P_5e-08 PRSWEB_PHECODE204.4_GWAS-Catalog-r2019-05-03-X204.4_P_5e-08_UKB_20200608 204.4 Multiple myeloma (hyperdiploidy);Multiple myeloma (IgH translocation);Multiple myeloma;Multiple myeloma and monoclonal gammopathy Binary 70 unique SNPs UKB UK Biobank GWAS Hits GWAS Catalog (2019-05-03) 22120009;23502783;23955597;26007630;27363682;30213928 https://www.ncbi.nlm.nih.gov/pubmed/?term=22120009+23502783+23955597+26007630+27363682+30213928 22 2e-05 0.0268105 0.0818 0.577 0.537-0.617 OR 2.2 0.855-5.66 2.2 0.855-5.66 3.01 1.64-5.51 3.01 1.64-5.51 1.6 0.977-2.64 1.6 0.977-2.64 1.85 1.3-2.64 1.85 1.3-2.64 1.68 1.28-2.21 1.68 1.28-2.21 1.36 0.907-2.03 0.137 1.34 0.896-2.01 0.154 2.05 1.41-2.99 0.000185 TRUE FALSE FALSE TRUE Both 248 2490 GRCh37/hg19 P<=5e-08 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000653/ScoringFiles/ phewas/PRSWEB_PHECODE204.4_GWAS-Catalog-r2019-05-03-X204.4_P_5e-08_UKB_20200608/all.tsv phewas/PRSWEB_PHECODE204.4_GWAS-Catalog-r2019-05-03-X204.4_P_5e-08_UKB_20200608/exclusion.tsv 2020-06-08 prsweb-phecode204-4-gwas-catalog-r2019-05-03-x204-4-pt-ukb-20200608 prsweb-phecode204-4-gwas-catalog-r2019-05-03-x204-4-pt-ukb-20200608 PRSWEB_PHECODE204.4_GWAS-Catalog-r2019-05-03-X204.4_PT_UKB_20200608 P&T PRSWEB_PHECODE204.4_GWAS-Catalog-r2019-05-03-X204.4_PT_UKB_20200608 204.4 Multiple myeloma (hyperdiploidy);Multiple myeloma (IgH translocation);Multiple myeloma;Multiple myeloma and monoclonal gammopathy Binary 70 unique SNPs UKB UK Biobank P&T GWAS Catalog (2019-05-03) 22120009;23502783;23955597;26007630;27363682;30213928 https://www.ncbi.nlm.nih.gov/pubmed/?term=22120009+23502783+23955597+26007630+27363682+30213928 21 3.4e-05 0.0277321 0.0818 0.576 0.536-0.616 OR 2.2 0.854-5.66 2.2 0.854-5.66 2.78 1.49-5.17 2.78 1.49-5.17 1.52 0.913-2.52 1.52 0.913-2.52 1.59 1.1-2.31 1.59 1.1-2.31 1.65 1.26-2.17 1.65 1.26-2.17 1.22 0.821-1.81 0.325 1.19 0.801-1.78 0.384 1.84 1.28-2.67 0.00111 TRUE FALSE FALSE TRUE Both 248 2490 GRCh37/hg19 P<=2.51e-08 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000654/ScoringFiles/ phewas/PRSWEB_PHECODE204.4_GWAS-Catalog-r2019-05-03-X204.4_PT_UKB_20200608/all.tsv phewas/PRSWEB_PHECODE204.4_GWAS-Catalog-r2019-05-03-X204.4_PT_UKB_20200608/exclusion.tsv 2020-06-08 prsweb-phecode209-gwas-catalog-r2019-05-03-x209-p-5e-05-mgi-20200608 prsweb-phecode209-gwas-catalog-r2019-05-03-x209-p-5e-05-mgi-20200608 PRSWEB_PHECODE209_GWAS-Catalog-r2019-05-03-X209_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE209_GWAS-Catalog-r2019-05-03-X209_P_5e-05_MGI_20200608 209 Neuroblastoma;Neuroblastoma (high-risk);Sporadic neuroblastoma;Neuroblastoma (11q deletion) Binary 16 unique SNPs MGI Michigan Genomics Initiative Fixed threshold (5e-05) GWAS Catalog (2019-05-03) 18463370;19412175;22941191;28545128;28924153 https://www.ncbi.nlm.nih.gov/pubmed/?term=18463370+19412175+22941191+28545128+28924153 10 0.36 0.000435075 0.0826 0.517 0.459-0.572 OR 1.18 0.204-6.85 1.18 0.204-6.85 1.06 0.278-4.02 1.06 0.278-4.02 1.15 0.499-2.66 1.15 0.499-2.66 1.33 0.745-2.39 1.33 0.745-2.39 1.22 0.799-1.88 1.22 0.799-1.88 1.15 0.654-2.01 0.633 1.16 0.662-2.03 0.605 1.3 0.755-2.24 0.343 FALSE FALSE FALSE FALSE Both 111 1110 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode209-gwas-catalog-r2019-05-03-x209-p-5e-06-mgi-20200608 prsweb-phecode209-gwas-catalog-r2019-05-03-x209-p-5e-06-mgi-20200608 PRSWEB_PHECODE209_GWAS-Catalog-r2019-05-03-X209_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE209_GWAS-Catalog-r2019-05-03-X209_P_5e-06_MGI_20200608 209 Neuroblastoma;Neuroblastoma (high-risk);Sporadic neuroblastoma;Neuroblastoma (11q deletion) Binary 16 unique SNPs MGI Michigan Genomics Initiative Fixed threshold (5e-06) GWAS Catalog (2019-05-03) 18463370;19412175;22941191;28545128;28924153 https://www.ncbi.nlm.nih.gov/pubmed/?term=18463370+19412175+22941191+28545128+28924153 10 0.36 0.000435075 0.0826 0.517 0.459-0.572 OR 1.18 0.204-6.85 1.18 0.204-6.85 1.06 0.278-4.02 1.06 0.278-4.02 1.15 0.499-2.66 1.15 0.499-2.66 1.33 0.745-2.39 1.33 0.745-2.39 1.22 0.799-1.88 1.22 0.799-1.88 1.15 0.654-2.01 0.633 1.16 0.662-2.03 0.605 1.3 0.755-2.24 0.343 FALSE FALSE FALSE FALSE Both 111 1110 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode209-gwas-catalog-r2019-05-03-x209-p-5e-07-mgi-20200608 prsweb-phecode209-gwas-catalog-r2019-05-03-x209-p-5e-07-mgi-20200608 PRSWEB_PHECODE209_GWAS-Catalog-r2019-05-03-X209_P_5e-07_MGI_20200608 P_5e-07 PRSWEB_PHECODE209_GWAS-Catalog-r2019-05-03-X209_P_5e-07_MGI_20200608 209 Neuroblastoma;Neuroblastoma (high-risk);Sporadic neuroblastoma;Neuroblastoma (11q deletion) Binary 16 unique SNPs MGI Michigan Genomics Initiative Fixed threshold (5e-07) GWAS Catalog (2019-05-03) 18463370;19412175;22941191;28545128;28924153 https://www.ncbi.nlm.nih.gov/pubmed/?term=18463370+19412175+22941191+28545128+28924153 10 0.36 0.000435075 0.0826 0.517 0.459-0.572 OR 1.18 0.204-6.85 1.18 0.204-6.85 1.06 0.278-4.02 1.06 0.278-4.02 1.15 0.499-2.66 1.15 0.499-2.66 1.33 0.745-2.39 1.33 0.745-2.39 1.22 0.799-1.88 1.22 0.799-1.88 1.15 0.654-2.01 0.633 1.16 0.662-2.03 0.605 1.3 0.755-2.24 0.343 FALSE FALSE FALSE FALSE Both 111 1110 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode209-gwas-catalog-r2019-05-03-x209-p-5e-09-mgi-20200608 prsweb-phecode209-gwas-catalog-r2019-05-03-x209-p-5e-09-mgi-20200608 PRSWEB_PHECODE209_GWAS-Catalog-r2019-05-03-X209_P_5e-09_MGI_20200608 P_5e-09 PRSWEB_PHECODE209_GWAS-Catalog-r2019-05-03-X209_P_5e-09_MGI_20200608 209 Neuroblastoma;Neuroblastoma (high-risk);Sporadic neuroblastoma;Neuroblastoma (11q deletion) Binary 16 unique SNPs MGI Michigan Genomics Initiative Fixed threshold (5e-09) GWAS Catalog (2019-05-03) 18463370;19412175;22941191;28545128;28924153 https://www.ncbi.nlm.nih.gov/pubmed/?term=18463370+19412175+22941191+28545128+28924153 7 0.6 0.000552389 0.0826 0.507 0.452-0.56 OR 0 0-0 0 0-0 1.06 0.278-4.03 1.06 0.278-4.03 1.34 0.611-2.96 1.34 0.611-2.96 1.23 0.677-2.24 1.23 0.677-2.24 0.973 0.622-1.52 0.973 0.622-1.52 1.52 0.862-2.7 0.148 1.67 0.945-2.96 0.0776 1.34 0.748-2.41 0.323 FALSE FALSE FALSE FALSE Both 111 1110 GRCh37/hg19 P<=5e-09 2020-06-08 prsweb-phecode209-gwas-catalog-r2019-05-03-x209-p-5e-08-mgi-20200608 prsweb-phecode209-gwas-catalog-r2019-05-03-x209-p-5e-08-mgi-20200608 PRSWEB_PHECODE209_GWAS-Catalog-r2019-05-03-X209_P_5e-08_MGI_20200608 P_5e-08 PRSWEB_PHECODE209_GWAS-Catalog-r2019-05-03-X209_P_5e-08_MGI_20200608 209 Neuroblastoma;Neuroblastoma (high-risk);Sporadic neuroblastoma;Neuroblastoma (11q deletion) Binary 16 unique SNPs MGI Michigan Genomics Initiative GWAS Hits GWAS Catalog (2019-05-03) 18463370;19412175;22941191;28545128;28924153 https://www.ncbi.nlm.nih.gov/pubmed/?term=18463370+19412175+22941191+28545128+28924153 10 0.36 0.000435075 0.0826 0.517 0.459-0.572 OR 1.18 0.204-6.85 1.18 0.204-6.85 1.06 0.278-4.02 1.06 0.278-4.02 1.15 0.499-2.66 1.15 0.499-2.66 1.33 0.745-2.39 1.33 0.745-2.39 1.22 0.799-1.88 1.22 0.799-1.88 1.15 0.654-2.01 0.633 1.16 0.662-2.03 0.605 1.3 0.755-2.24 0.343 FALSE FALSE FALSE FALSE Both 111 1110 GRCh37/hg19 P<=5e-08 2020-06-08 prsweb-phecode209-gwas-catalog-r2019-05-03-x209-pt-mgi-20200608 prsweb-phecode209-gwas-catalog-r2019-05-03-x209-pt-mgi-20200608 PRSWEB_PHECODE209_GWAS-Catalog-r2019-05-03-X209_PT_MGI_20200608 P&T PRSWEB_PHECODE209_GWAS-Catalog-r2019-05-03-X209_PT_MGI_20200608 209 Neuroblastoma;Neuroblastoma (high-risk);Sporadic neuroblastoma;Neuroblastoma (11q deletion) Binary 16 unique SNPs MGI Michigan Genomics Initiative P&T GWAS Catalog (2019-05-03) 18463370;19412175;22941191;28545128;28924153 https://www.ncbi.nlm.nih.gov/pubmed/?term=18463370+19412175+22941191+28545128+28924153 7 0.6 0.000552389 0.0826 0.507 0.452-0.56 OR 0 0-0 0 0-0 1.06 0.278-4.03 1.06 0.278-4.03 1.34 0.611-2.96 1.34 0.611-2.96 1.23 0.677-2.24 1.23 0.677-2.24 0.973 0.622-1.52 0.973 0.622-1.52 1.52 0.862-2.7 0.148 1.67 0.945-2.96 0.0776 1.34 0.748-2.41 0.323 FALSE FALSE FALSE FALSE Both 111 1110 GRCh37/hg19 P<=3.16e-10 2020-06-08