prs_id slug legacy_id legacy_model prswebprefix trait_code trait_name trait_type description cohort cohort_label method gwas_source reference_label reference_url snp_count p_value pseudo_r2 brier_score mse aauc aauc_ci effect_metric top_effect_1 top_effect_1_ci top_or_1 top_or_1_ci top_effect_2 top_effect_2_ci top_or_2 top_or_2_ci top_effect_5 top_effect_5_ci top_or_5 top_or_5_ci top_effect_10 top_effect_10_ci top_or_10 top_or_10_ci top_effect_25 top_effect_25_ci top_or_25 top_or_25_ci q1_vs_q2_effect q1_vs_q2_effect_ci q1_vs_q2_p_value q1_vs_q3_effect q1_vs_q3_effect_ci q1_vs_q3_p_value q1_vs_q4_effect q1_vs_q4_effect_ci q1_vs_q4_p_value nominally_significant reversed_effect_warning underpowered_warning upload_to_portal sex cases controls genome_build tuning_parameter weights_external_url weights_url phewas_download_url exclusion_download_url last_updated prsweb-phecode153-3-c19-p-5e-05-mgi-20200608 prsweb-phecode153-3-c19-p-5e-05-mgi-20200608 PRSWEB_PHECODE153.3_C19_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE153.3_C19_P_5e-05_MGI_20200608 153.3 Diagnoses - main ICD10: C19 Malignant neoplasm of rectosigmoid junction Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 102 0.17 0.000648642 0.0829 0.522 0.49-0.555 OR 1.33 0.49-3.63 1.33 0.49-3.63 1.3 0.629-2.69 1.3 0.629-2.69 1.01 0.602-1.7 1.01 0.602-1.7 1.06 0.733-1.54 1.06 0.733-1.54 1.18 0.919-1.52 1.18 0.919-1.52 1.26 0.902-1.75 0.177 1.17 0.838-1.64 0.356 1.34 0.966-1.85 0.08 False False False False Both 325 3232 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode153-3-c21-p-5e-05-mgi-20200608 prsweb-phecode153-3-c21-p-5e-05-mgi-20200608 PRSWEB_PHECODE153.3_C21_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE153.3_C21_P_5e-05_MGI_20200608 153.3 Diagnoses - main ICD10: C21 Malignant neoplasm of anus and anal canal Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 64 0.44 0.00261431 0.083 0.509 0.475-0.544 OR 1.05 0.343-3.22 1.05 0.343-3.22 0.997 0.44-2.26 0.997 0.44-2.26 0.826 0.468-1.46 0.826 0.468-1.46 1.14 0.792-1.63 1.14 0.792-1.63 1.02 0.785-1.33 1.02 0.785-1.33 0.868 0.622-1.21 0.402 1.17 0.854-1.59 0.331 1.01 0.735-1.4 0.935 False False False False Both 325 3232 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode153-3-c3-anus-analcanal-p-5e-05-mgi-20200608 prsweb-phecode153-3-c3-anus-analcanal-p-5e-05-mgi-20200608 PRSWEB_PHECODE153.3_C3-ANUS-ANALCANAL_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE153.3_C3-ANUS-ANALCANAL_P_5e-05_MGI_20200608 153.3 Malignant neoplasm of anus and anal canal Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 70 0.74 0.00073509 0.083 0.496 0.465-0.53 OR 1.34 0.491-3.64 1.34 0.491-3.64 1.46 0.728-2.91 1.46 0.728-2.91 1.08 0.65-1.79 1.08 0.65-1.79 0.926 0.627-1.37 0.926 0.627-1.37 1.04 0.798-1.34 1.04 0.798-1.34 1.1 0.792-1.53 0.567 1.19 0.863-1.65 0.284 1.13 0.816-1.57 0.458 False False False False Both 325 3232 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode153-3-c3-rectum-p-5e-05-mgi-20200608 prsweb-phecode153-3-c3-rectum-p-5e-05-mgi-20200608 PRSWEB_PHECODE153.3_C3-RECTUM_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE153.3_C3-RECTUM_P_5e-05_MGI_20200608 153.3 Malignant neoplasm of rectum Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 155 0.72 0.000150999 0.083 0.504 0.475-0.537 OR 0.434 0.0827-2.28 0.434 0.0827-2.28 0.969 0.428-2.2 0.969 0.428-2.2 0.997 0.593-1.68 0.997 0.593-1.68 1.16 0.811-1.66 1.16 0.811-1.66 0.919 0.703-1.2 0.919 0.703-1.2 0.988 0.712-1.37 0.944 1.2 0.881-1.65 0.244 0.971 0.7-1.35 0.859 False False False False Both 325 3232 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode153-3-c20-p-5e-06-mgi-20200608 prsweb-phecode153-3-c20-p-5e-06-mgi-20200608 PRSWEB_PHECODE153.3_C20_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE153.3_C20_P_5e-06_MGI_20200608 153.3 Diagnoses - main ICD10: C20 Malignant neoplasm of rectum Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 19 0.93 0.000504886 0.083 0.49 0.459-0.522 OR 1.05 0.343-3.22 1.05 0.343-3.22 0.827 0.343-2 0.827 0.343-2 0.934 0.547-1.59 0.934 0.547-1.59 0.924 0.626-1.36 0.924 0.626-1.36 1.09 0.839-1.41 1.09 0.839-1.41 1.08 0.781-1.49 0.644 1.05 0.754-1.45 0.786 1.12 0.811-1.54 0.495 False False False False Both 325 3232 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode153-3-c21-p-5e-06-mgi-20200608 prsweb-phecode153-3-c21-p-5e-06-mgi-20200608 PRSWEB_PHECODE153.3_C21_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE153.3_C21_P_5e-06_MGI_20200608 153.3 Diagnoses - main ICD10: C21 Malignant neoplasm of anus and anal canal Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 16 0.52 0.00267936 0.083 0.499 0.467-0.535 OR 0.444 0.0847-2.33 0.444 0.0847-2.33 1.61 0.83-3.14 1.61 0.83-3.14 0.818 0.464-1.44 0.818 0.464-1.44 0.828 0.552-1.24 0.828 0.552-1.24 1.14 0.882-1.47 1.14 0.882-1.47 1.12 0.81-1.56 0.486 1.1 0.79-1.53 0.573 1.21 0.878-1.67 0.243 False False False False Both 325 3232 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode153-3-c3-rectum-p-5e-06-mgi-20200608 prsweb-phecode153-3-c3-rectum-p-5e-06-mgi-20200608 PRSWEB_PHECODE153.3_C3-RECTUM_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE153.3_C3-RECTUM_P_5e-06_MGI_20200608 153.3 Malignant neoplasm of rectum Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 19 0.36 1.46023e-05 0.083 0.493 0.462-0.526 OR 1.65 0.66-4.15 1.65 0.66-4.15 1.3 0.63-2.7 1.3 0.63-2.7 1.35 0.847-2.15 1.35 0.847-2.15 1.03 0.709-1.5 1.03 0.709-1.5 1.02 0.784-1.32 1.02 0.784-1.32 0.94 0.675-1.31 0.717 1.2 0.875-1.65 0.257 1.06 0.77-1.47 0.705 False False False False Both 325 3232 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode153-3-ukbb-saige-hrc-x153-3-p-5e-06-mgi-20200608 prsweb-phecode153-3-ukbb-saige-hrc-x153-3-p-5e-06-mgi-20200608 PRSWEB_PHECODE153.3_UKBB-SAIGE-HRC-X153.3_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE153.3_UKBB-SAIGE-HRC-X153.3_P_5e-06_MGI_20200608 153.3 Malignant neoplasm of rectum, rectosigmoid junction, and anus Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 17 0.45 0.000994186 0.083 0.502 0.466-0.533 OR 1.63 0.651-4.09 1.63 0.651-4.09 1.29 0.621-2.66 1.29 0.621-2.66 1.07 0.644-1.78 1.07 0.644-1.78 1.24 0.871-1.76 1.24 0.871-1.76 1.05 0.813-1.37 1.05 0.813-1.37 1.16 0.836-1.61 0.375 1.16 0.835-1.6 0.383 1.15 0.828-1.59 0.405 False False False False Both 325 3232 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode153-3-c21-p-5e-07-mgi-20200608 prsweb-phecode153-3-c21-p-5e-07-mgi-20200608 PRSWEB_PHECODE153.3_C21_P_5e-07_MGI_20200608 P_5e-07 PRSWEB_PHECODE153.3_C21_P_5e-07_MGI_20200608 153.3 Diagnoses - main ICD10: C21 Malignant neoplasm of anus and anal canal Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-07) UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 8 0.94 0.00180693 0.083 0.484 0.452-0.518 OR 1.04 0.341-3.2 1.04 0.341-3.2 0.988 0.436-2.24 0.988 0.436-2.24 0.821 0.466-1.45 0.821 0.466-1.45 0.996 0.681-1.46 0.996 0.681-1.46 1.05 0.813-1.37 1.05 0.813-1.37 1.02 0.74-1.41 0.899 1.02 0.741-1.41 0.889 1.06 0.769-1.46 0.724 False False False False Both 325 3232 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode153-3-c20-pt-mgi-20200608 prsweb-phecode153-3-c20-pt-mgi-20200608 PRSWEB_PHECODE153.3_C20_PT_MGI_20200608 P&T PRSWEB_PHECODE153.3_C20_PT_MGI_20200608 153.3 Diagnoses - main ICD10: C20 Malignant neoplasm of rectum Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative P&T UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 16 0.8 0.000759142 0.083 0.488 0.457-0.521 OR 1.04 0.34-3.19 1.04 0.34-3.19 0.986 0.435-2.23 0.986 0.435-2.23 0.943 0.553-1.61 0.943 0.553-1.61 1.09 0.759-1.58 1.09 0.759-1.58 1.04 0.798-1.34 1.04 0.798-1.34 1.11 0.805-1.54 0.517 1.13 0.815-1.56 0.467 1.12 0.808-1.55 0.498 False False False False Both 325 3232 GRCh37/hg19 P<=3.16e-06 2020-06-08 prsweb-phecode153-3-c21-pt-mgi-20200608 prsweb-phecode153-3-c21-pt-mgi-20200608 PRSWEB_PHECODE153.3_C21_PT_MGI_20200608 P&T PRSWEB_PHECODE153.3_C21_PT_MGI_20200608 153.3 Diagnoses - main ICD10: C21 Malignant neoplasm of anus and anal canal Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative P&T UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 46 0.34 0.00380837 0.083 0.512 0.477-0.547 OR 1.34 0.493-3.65 1.34 0.493-3.65 1.14 0.528-2.45 1.14 0.528-2.45 0.946 0.554-1.61 0.946 0.554-1.61 0.966 0.658-1.42 0.966 0.658-1.42 1.07 0.827-1.39 1.07 0.827-1.39 1.13 0.814-1.58 0.457 1.3 0.938-1.8 0.115 1.19 0.858-1.66 0.294 False False False False Both 325 3232 GRCh37/hg19 P<=3.16e-05 2020-06-08 prsweb-phecode153-3-c3-rectoisigmoid-junction-pt-mgi-20200608 prsweb-phecode153-3-c3-rectoisigmoid-junction-pt-mgi-20200608 PRSWEB_PHECODE153.3_C3-RECTOISIGMOID-JUNCTION_PT_MGI_20200608 P&T PRSWEB_PHECODE153.3_C3-RECTOISIGMOID-JUNCTION_PT_MGI_20200608 153.3 Malignant neoplasm of rectosigmoid junction Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative P&T UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 21 0.9 0.000835021 0.083 0.493 0.462-0.526 OR 0.731 0.199-2.69 0.731 0.199-2.69 0.827 0.343-2 0.827 0.343-2 1.21 0.747-1.97 1.21 0.747-1.97 1.27 0.895-1.8 1.27 0.895-1.8 1.05 0.806-1.36 1.05 0.806-1.36 1.01 0.734-1.39 0.952 0.93 0.671-1.29 0.661 1.02 0.742-1.41 0.895 False False False False Both 325 3232 GRCh37/hg19 P<=7.94e-06 2020-06-08 prsweb-phecode153-3-c3-rectum-pt-mgi-20200608 prsweb-phecode153-3-c3-rectum-pt-mgi-20200608 PRSWEB_PHECODE153.3_C3-RECTUM_PT_MGI_20200608 P&T PRSWEB_PHECODE153.3_C3-RECTUM_PT_MGI_20200608 153.3 Malignant neoplasm of rectum Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative P&T UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 110 0.84 0.000754129 0.083 0.5 0.47-0.533 OR 1.03 0.337-3.16 1.03 0.337-3.16 1.13 0.523-2.43 1.13 0.523-2.43 0.748 0.416-1.35 0.748 0.416-1.35 0.924 0.626-1.36 0.924 0.626-1.36 0.997 0.767-1.3 0.997 0.767-1.3 1.07 0.775-1.48 0.682 1.09 0.789-1.51 0.601 1.05 0.759-1.45 0.771 False False False False Both 325 3232 GRCh37/hg19 P<=3.16e-05 2020-06-08 prsweb-phecode153-3-ukbb-saige-hrc-x153-3-pt-mgi-20200608 prsweb-phecode153-3-ukbb-saige-hrc-x153-3-pt-mgi-20200608 PRSWEB_PHECODE153.3_UKBB-SAIGE-HRC-X153.3_PT_MGI_20200608 P&T PRSWEB_PHECODE153.3_UKBB-SAIGE-HRC-X153.3_PT_MGI_20200608 153.3 Malignant neoplasm of rectum, rectosigmoid junction, and anus Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative P&T UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 13 0.64 0.00171408 0.083 0.498 0.466-0.531 OR 2.28 1.01-5.12 2.28 1.01-5.12 1.15 0.533-2.47 1.15 0.533-2.47 0.947 0.556-1.62 0.947 0.556-1.62 0.999 0.683-1.46 0.999 0.683-1.46 1.12 0.869-1.45 1.12 0.869-1.45 1.15 0.83-1.59 0.405 1.02 0.735-1.42 0.898 1.16 0.844-1.61 0.354 False False False False Both 325 3232 GRCh37/hg19 P<=3.98e-06 2020-06-08 prsweb-phecode153-3-20001-1023-prs-cs-mgi-20200608 prsweb-phecode153-3-20001-1023-prs-cs-mgi-20200608 PRSWEB_PHECODE153.3_20001-1023_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE153.3_20001-1023_PRS-CS_MGI_20200608 153.3 Cancer code, self-reported: rectal cancer Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative PRS-CS UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1018916 0.61 0.000172588 0.083 0.507 0.475-0.54 OR 1.35 0.494-3.67 1.35 0.494-3.67 1.14 0.53-2.46 1.14 0.53-2.46 0.945 0.554-1.61 0.945 0.554-1.61 1.13 0.786-1.62 1.13 0.786-1.62 1.07 0.822-1.38 1.07 0.822-1.38 1.21 0.878-1.66 0.248 0.968 0.693-1.35 0.846 1.12 0.81-1.54 0.501 False False False False Both 325 3232 GRCh37/hg19 auto 2020-06-08 prsweb-phecode153-3-c19-prs-cs-mgi-20200608 prsweb-phecode153-3-c19-prs-cs-mgi-20200608 PRSWEB_PHECODE153.3_C19_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE153.3_C19_PRS-CS_MGI_20200608 153.3 Diagnoses - main ICD10: C19 Malignant neoplasm of rectosigmoid junction Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative PRS-CS UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1078799 0.04 0.000195485 0.0829 0.533 0.5-0.567 OR 1.34 0.491-3.65 1.34 0.491-3.65 1.76 0.929-3.34 1.76 0.929-3.34 1.6 1.04-2.48 1.6 1.04-2.48 1.39 0.988-1.95 1.39 0.988-1.95 1.26 0.984-1.62 1.26 0.984-1.62 1.23 0.885-1.71 0.218 1.05 0.747-1.47 0.782 1.39 1.01-1.92 0.0447 True False False True Both 325 3232 GRCh37/hg19 auto https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000383/ScoringFiles/ https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000383/ScoringFiles/ /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE153.3_C19_PRS-CS_MGI_20200608/all.tsv /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE153.3_C19_PRS-CS_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode153-3-c20-prs-cs-mgi-20200608 prsweb-phecode153-3-c20-prs-cs-mgi-20200608 PRSWEB_PHECODE153.3_C20_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE153.3_C20_PRS-CS_MGI_20200608 153.3 Diagnoses - main ICD10: C20 Malignant neoplasm of rectum Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative PRS-CS UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1104940 0.34 0.000138122 0.083 0.521 0.488-0.553 OR 0 0-0 0 0-0 0.377 0.106-1.35 0.377 0.106-1.35 0.563 0.29-1.09 0.563 0.29-1.09 1.12 0.781-1.61 1.12 0.781-1.61 1.13 0.877-1.46 1.13 0.877-1.46 1.08 0.773-1.5 0.66 1.19 0.855-1.64 0.307 1.25 0.904-1.73 0.177 False False False False Both 325 3232 GRCh37/hg19 auto 2020-06-08 prsweb-phecode153-3-c21-prs-cs-mgi-20200608 prsweb-phecode153-3-c21-prs-cs-mgi-20200608 PRSWEB_PHECODE153.3_C21_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE153.3_C21_PRS-CS_MGI_20200608 153.3 Diagnoses - main ICD10: C21 Malignant neoplasm of anus and anal canal Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative PRS-CS UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 923679 0.19 0.000109097 0.0829 0.528 0.493-0.564 OR 1.65 0.658-4.13 1.65 0.658-4.13 1.44 0.72-2.88 1.44 0.72-2.88 1.2 0.739-1.95 1.2 0.739-1.95 1.2 0.84-1.71 1.2 0.84-1.71 1.44 1.12-1.84 1.44 1.12-1.84 0.817 0.582-1.15 0.242 0.937 0.675-1.3 0.695 1.31 0.968-1.78 0.0794 False False False False Both 325 3232 GRCh37/hg19 auto 2020-06-08 prsweb-phecode153-3-c3-anus-analcanal-prs-cs-mgi-20200608 prsweb-phecode153-3-c3-anus-analcanal-prs-cs-mgi-20200608 PRSWEB_PHECODE153.3_C3-ANUS-ANALCANAL_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE153.3_C3-ANUS-ANALCANAL_PRS-CS_MGI_20200608 153.3 Malignant neoplasm of anus and anal canal Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative PRS-CS UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 877060 0.12 0.000647598 0.0829 0.528 0.495-0.562 OR 1.33 0.487-3.61 1.33 0.487-3.61 1.29 0.625-2.68 1.29 0.625-2.68 1.33 0.835-2.12 1.33 0.835-2.12 1.3 0.921-1.84 1.3 0.921-1.84 1.3 1.01-1.67 1.3 1.01-1.67 1.08 0.779-1.51 0.635 1.03 0.736-1.43 0.877 1.34 0.974-1.83 0.072 False False False False Both 325 3232 GRCh37/hg19 auto 2020-06-08 prsweb-phecode153-3-c3-rectoisigmoid-junction-prs-cs-mgi-20200608 prsweb-phecode153-3-c3-rectoisigmoid-junction-prs-cs-mgi-20200608 PRSWEB_PHECODE153.3_C3-RECTOISIGMOID-JUNCTION_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE153.3_C3-RECTOISIGMOID-JUNCTION_PRS-CS_MGI_20200608 153.3 Malignant neoplasm of rectosigmoid junction Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative PRS-CS UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1040423 0.097 0.000407518 0.0829 0.533 0.503-0.565 OR 0.441 0.0841-2.31 0.441 0.0841-2.31 0.982 0.434-2.22 0.982 0.434-2.22 0.943 0.553-1.61 0.943 0.553-1.61 1.06 0.73-1.53 1.06 0.73-1.53 1.18 0.917-1.52 1.18 0.917-1.52 1.15 0.822-1.61 0.411 1.31 0.942-1.83 0.108 1.34 0.965-1.85 0.0812 False False False False Both 325 3232 GRCh37/hg19 auto 2020-06-08 prsweb-phecode153-3-c3-rectum-prs-cs-mgi-20200608 prsweb-phecode153-3-c3-rectum-prs-cs-mgi-20200608 PRSWEB_PHECODE153.3_C3-RECTUM_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE153.3_C3-RECTUM_PRS-CS_MGI_20200608 153.3 Malignant neoplasm of rectum Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative PRS-CS UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1104018 0.048 0.000530638 0.0829 0.531 0.495-0.563 OR 1.02 0.334-3.14 1.02 0.334-3.14 1.12 0.521-2.42 1.12 0.521-2.42 1.19 0.73-1.93 1.19 0.73-1.93 1.33 0.945-1.87 1.33 0.945-1.87 1.22 0.946-1.57 1.22 0.946-1.57 0.978 0.693-1.38 0.898 1.32 0.953-1.82 0.0946 1.35 0.98-1.87 0.0659 True False False True Both 325 3232 GRCh37/hg19 auto https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000384/ScoringFiles/ https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000384/ScoringFiles/ /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE153.3_C3-RECTUM_PRS-CS_MGI_20200608/all.tsv /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE153.3_C3-RECTUM_PRS-CS_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode153-3-ukbb-saige-hrc-x153-3-prs-cs-mgi-20200608 prsweb-phecode153-3-ukbb-saige-hrc-x153-3-prs-cs-mgi-20200608 PRSWEB_PHECODE153.3_UKBB-SAIGE-HRC-X153.3_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE153.3_UKBB-SAIGE-HRC-X153.3_PRS-CS_MGI_20200608 153.3 Malignant neoplasm of rectum, rectosigmoid junction, and anus Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative PRS-CS UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1119238 0.074 0.000569835 0.0829 0.536 0.501-0.569 OR 0.737 0.2-2.72 0.737 0.2-2.72 0.983 0.435-2.23 0.983 0.435-2.23 1.47 0.939-2.3 1.47 0.939-2.3 1.21 0.846-1.72 1.21 0.846-1.72 1.28 1-1.65 1.28 1-1.65 0.813 0.575-1.15 0.244 1.18 0.854-1.62 0.32 1.3 0.945-1.78 0.107 False False False False Both 325 3232 GRCh37/hg19 auto 2020-06-08 prsweb-phecode153-3-20001-1023-lassosum-mgi-20200608 prsweb-phecode153-3-20001-1023-lassosum-mgi-20200608 PRSWEB_PHECODE153.3_20001-1023_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE153.3_20001-1023_LASSOSUM_MGI_20200608 153.3 Cancer code, self-reported: rectal cancer Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative lassosum UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 183063 0.59 0.000963595 0.083 0.507 0.47-0.541 OR 0.742 0.201-2.73 0.742 0.201-2.73 1.27 0.615-2.64 1.27 0.615-2.64 1.26 0.783-2.02 1.26 0.783-2.02 1.41 1.01-1.98 1.41 1.01-1.98 1.17 0.908-1.51 1.17 0.908-1.51 0.818 0.594-1.13 0.216 0.731 0.528-1.01 0.0599 0.987 0.728-1.34 0.933 False False False False Both 325 3232 GRCh37/hg19 s=1;Lambda=0.06158 2020-06-08 prsweb-phecode153-3-c19-lassosum-mgi-20200608 prsweb-phecode153-3-c19-lassosum-mgi-20200608 PRSWEB_PHECODE153.3_C19_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE153.3_C19_LASSOSUM_MGI_20200608 153.3 Diagnoses - main ICD10: C19 Malignant neoplasm of rectosigmoid junction Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative lassosum UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 2154790 0.081 0.000669785 0.0829 0.53 0.498-0.563 OR 0.441 0.0841-2.31 0.441 0.0841-2.31 0.974 0.43-2.21 0.974 0.43-2.21 1.47 0.935-2.3 1.47 0.935-2.3 1.24 0.869-1.76 1.24 0.869-1.76 1.26 0.979-1.62 1.26 0.979-1.62 1.13 0.808-1.58 0.477 1.17 0.841-1.64 0.346 1.38 0.997-1.91 0.0519 False False False False Both 325 3232 GRCh37/hg19 s=0.2;Lambda=0.002637 2020-06-08 prsweb-phecode153-3-c20-lassosum-mgi-20200608 prsweb-phecode153-3-c20-lassosum-mgi-20200608 PRSWEB_PHECODE153.3_C20_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE153.3_C20_LASSOSUM_MGI_20200608 153.3 Diagnoses - main ICD10: C20 Malignant neoplasm of rectum Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative lassosum UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 4790230 0.28 0.00158146 0.083 0.524 0.493-0.557 OR 0 0-0 0 0-0 0.825 0.342-1.99 0.825 0.342-1.99 1.01 0.598-1.69 1.01 0.598-1.69 1.09 0.757-1.58 1.09 0.757-1.58 1.12 0.866-1.45 1.12 0.866-1.45 1 0.715-1.4 0.995 1.24 0.901-1.71 0.186 1.2 0.865-1.65 0.28 False False False False Both 325 3232 GRCh37/hg19 s=1;Lambda=0.004281 2020-06-08 prsweb-phecode153-3-c21-lassosum-mgi-20200608 prsweb-phecode153-3-c21-lassosum-mgi-20200608 PRSWEB_PHECODE153.3_C21_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE153.3_C21_LASSOSUM_MGI_20200608 153.3 Diagnoses - main ICD10: C21 Malignant neoplasm of anus and anal canal Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative lassosum UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 67145 0.36 0.00218349 0.083 0.521 0.488-0.555 OR 1.06 0.345-3.25 1.06 0.345-3.25 0.837 0.347-2.02 0.837 0.347-2.02 0.759 0.422-1.37 0.759 0.422-1.37 0.895 0.604-1.33 0.895 0.604-1.33 1.05 0.811-1.36 1.05 0.811-1.36 1.16 0.827-1.62 0.396 1.36 0.985-1.89 0.0616 1.24 0.892-1.73 0.199 False False False False Both 325 3232 GRCh37/hg19 s=1;Lambda=0.1 2020-06-08 prsweb-phecode153-3-c3-anus-analcanal-lassosum-mgi-20200608 prsweb-phecode153-3-c3-anus-analcanal-lassosum-mgi-20200608 PRSWEB_PHECODE153.3_C3-ANUS-ANALCANAL_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE153.3_C3-ANUS-ANALCANAL_LASSOSUM_MGI_20200608 153.3 Malignant neoplasm of anus and anal canal Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative lassosum UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 79687 0.43 0.00181689 0.083 0.527 0.493-0.558 OR 1.34 0.493-3.65 1.34 0.493-3.65 0.834 0.346-2.01 0.834 0.346-2.01 0.886 0.512-1.54 0.886 0.512-1.54 1.03 0.705-1.49 1.03 0.705-1.49 1 0.769-1.3 1 0.769-1.3 0.958 0.681-1.35 0.804 1.41 1.03-1.93 0.0331 1.12 0.807-1.56 0.494 False False False False Both 325 3232 GRCh37/hg19 s=1;Lambda=0.1 2020-06-08 prsweb-phecode153-3-c3-rectoisigmoid-junction-lassosum-mgi-20200608 prsweb-phecode153-3-c3-rectoisigmoid-junction-lassosum-mgi-20200608 PRSWEB_PHECODE153.3_C3-RECTOISIGMOID-JUNCTION_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE153.3_C3-RECTOISIGMOID-JUNCTION_LASSOSUM_MGI_20200608 153.3 Malignant neoplasm of rectosigmoid junction Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative lassosum UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 592740 0.23 0.00102663 0.0829 0.526 0.496-0.561 OR 1.01 0.331-3.1 1.01 0.331-3.1 1.13 0.523-2.43 1.13 0.523-2.43 1.14 0.693-1.86 1.14 0.693-1.86 1.09 0.758-1.58 1.09 0.758-1.58 1.17 0.906-1.51 1.17 0.906-1.51 1.25 0.904-1.74 0.175 1.07 0.768-1.51 0.674 1.3 0.941-1.81 0.11 False False False False Both 325 3232 GRCh37/hg19 s=0.9;Lambda=0.02976 2020-06-08 prsweb-phecode153-3-c3-rectum-lassosum-mgi-20200608 prsweb-phecode153-3-c3-rectum-lassosum-mgi-20200608 PRSWEB_PHECODE153.3_C3-RECTUM_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE153.3_C3-RECTUM_LASSOSUM_MGI_20200608 153.3 Malignant neoplasm of rectum Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative lassosum UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1249593 0.45 0.000666083 0.083 0.508 0.473-0.541 OR 1.34 0.493-3.66 1.34 0.493-3.66 1.62 0.835-3.16 1.62 0.835-3.16 1.41 0.89-2.22 1.41 0.89-2.22 1.09 0.756-1.57 1.09 0.756-1.57 1.03 0.795-1.34 1.03 0.795-1.34 0.895 0.646-1.24 0.507 1.03 0.754-1.42 0.833 1.01 0.73-1.38 0.974 False False False False Both 325 3232 GRCh37/hg19 s=0.5;Lambda=0.006952 2020-06-08 prsweb-phecode153-3-ukbb-saige-hrc-x153-3-lassosum-mgi-20200608 prsweb-phecode153-3-ukbb-saige-hrc-x153-3-lassosum-mgi-20200608 PRSWEB_PHECODE153.3_UKBB-SAIGE-HRC-X153.3_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE153.3_UKBB-SAIGE-HRC-X153.3_LASSOSUM_MGI_20200608 153.3 Malignant neoplasm of rectum, rectosigmoid junction, and anus Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative lassosum UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 68 0.078 0.00140425 0.0829 0.525 0.492-0.556 OR 2.25 1-5.06 2.25 1-5.06 1.92 1.03-3.56 1.92 1.03-3.56 1.87 1.24-2.82 1.87 1.24-2.82 1.46 1.04-2.03 1.46 1.04-2.03 1.34 1.05-1.72 1.34 1.05-1.72 1.15 0.83-1.6 0.398 0.989 0.703-1.39 0.95 1.38 1-1.89 0.0485 False False False False Both 325 3232 GRCh37/hg19 s=0.5;Lambda=0.04833 2020-06-08