prs_id slug legacy_id legacy_model prswebprefix trait_code trait_name trait_type description cohort cohort_label method gwas_source reference_label reference_url snp_count p_value pseudo_r2 brier_score mse aauc aauc_ci effect_metric top_effect_1 top_effect_1_ci top_or_1 top_or_1_ci top_effect_2 top_effect_2_ci top_or_2 top_or_2_ci top_effect_5 top_effect_5_ci top_or_5 top_or_5_ci top_effect_10 top_effect_10_ci top_or_10 top_or_10_ci top_effect_25 top_effect_25_ci top_or_25 top_or_25_ci q1_vs_q2_effect q1_vs_q2_effect_ci q1_vs_q2_p_value q1_vs_q3_effect q1_vs_q3_effect_ci q1_vs_q3_p_value q1_vs_q4_effect q1_vs_q4_effect_ci q1_vs_q4_p_value nominally_significant reversed_effect_warning underpowered_warning upload_to_portal sex cases controls genome_build tuning_parameter weights_external_url weights_url phewas_download_url exclusion_download_url last_updated prsweb-phecode153-20001-1020-p-5e-05-mgi-20200608 prsweb-phecode153-20001-1020-p-5e-05-mgi-20200608 PRSWEB_PHECODE153_20001-1020_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE153_20001-1020_P_5e-05_MGI_20200608 153 Cancer code, self-reported: large bowel cancer/colorectal cancer Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 99 0.46 0.000498831 0.0831 0.505 0.482-0.527 OR 1.38 0.668-2.86 1.38 0.668-2.86 0.855 0.452-1.62 0.855 0.452-1.62 1.03 0.709-1.51 1.03 0.709-1.51 0.904 0.677-1.21 0.904 0.677-1.21 1.01 0.834-1.22 1.01 0.834-1.22 1.29 1.01-1.63 0.0389 1.19 0.937-1.52 0.152 1.16 0.908-1.48 0.236 False False False False Both 607 6026 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode153-crc-huyghe-p-5e-05-mgi-20200608 prsweb-phecode153-crc-huyghe-p-5e-05-mgi-20200608 PRSWEB_PHECODE153_CRC-Huyghe_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE153_CRC-Huyghe_P_5e-05_MGI_20200608 153 Colorectal cancer Binary Supplementary Tables 11 & 15; Cases: Discovery: 34,869; Follow-up: 23,262; Controls: Discovery: 29,051; Follow-up: 38,296 controls MGI Michigan Genomics Initiative Fixed threshold (5e-05) Huyghe JR et al. 2019 30510241 https://www.ncbi.nlm.nih.gov/pubmed/?term=30510241 87 6.9e-06 0.0155196 0.0828 0.552 0.525-0.576 OR 2.39 1.33-4.27 2.39 1.33-4.27 2.48 1.64-3.74 2.48 1.64-3.74 1.61 1.17-2.21 1.61 1.17-2.21 1.47 1.16-1.88 1.47 1.16-1.88 1.54 1.29-1.84 1.54 1.29-1.84 1.06 0.823-1.36 0.662 1.06 0.824-1.36 0.655 1.6 1.27-2.02 6.71e-05 True False False False Both 607 6026 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode153-gwas-catalog-r2019-05-03-x153-p-5e-05-mgi-20200608 prsweb-phecode153-gwas-catalog-r2019-05-03-x153-p-5e-05-mgi-20200608 PRSWEB_PHECODE153_GWAS-Catalog-r2019-05-03-X153_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE153_GWAS-Catalog-r2019-05-03-X153_P_5e-05_MGI_20200608 153 Colorectal cancer Binary 37 unique SNPs MGI Michigan Genomics Initiative Fixed threshold (5e-05) GWAS Catalog (2019-05-03) 17618284;17934461;18372901;19011631;23266556;24737748;25990418;26151821;28960316 https://www.ncbi.nlm.nih.gov/pubmed/?term=17618284+17934461+18372901+19011631+23266556+24737748+25990418+26151821+28960316 27 0.095 0.00481477 0.083 0.516 0.492-0.538 OR 1.89 0.998-3.59 1.89 0.998-3.59 1.46 0.874-2.42 1.46 0.874-2.42 1.05 0.717-1.52 1.05 0.717-1.52 0.909 0.681-1.21 0.909 0.681-1.21 1.1 0.909-1.33 1.1 0.909-1.33 1.29 1.01-1.64 0.0405 1.22 0.952-1.55 0.117 1.28 1-1.63 0.0463 False False False False Both 607 6026 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode153-ukbb-saige-hrc-x153-p-5e-05-mgi-20200608 prsweb-phecode153-ukbb-saige-hrc-x153-p-5e-05-mgi-20200608 PRSWEB_PHECODE153_UKBB-SAIGE-HRC-X153_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE153_UKBB-SAIGE-HRC-X153_P_5e-05_MGI_20200608 153 Colorectal cancer Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 141 0.0034 0.0034341 0.083 0.53 0.506-0.554 OR 1.04 0.459-2.36 1.04 0.459-2.36 1.28 0.747-2.18 1.28 0.747-2.18 1.49 1.08-2.07 1.49 1.08-2.07 1.34 1.04-1.72 1.34 1.04-1.72 1.24 1.03-1.49 1.24 1.03-1.49 1.01 0.791-1.3 0.913 1.17 0.923-1.49 0.193 1.33 1.05-1.68 0.018 True False False False Both 607 6026 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode153-crc-huyghe-p-5e-06-mgi-20200608 prsweb-phecode153-crc-huyghe-p-5e-06-mgi-20200608 PRSWEB_PHECODE153_CRC-Huyghe_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE153_CRC-Huyghe_P_5e-06_MGI_20200608 153 Colorectal cancer Binary Supplementary Tables 11 & 15; Cases: Discovery: 34,869; Follow-up: 23,262; Controls: Discovery: 29,051; Follow-up: 38,296 controls MGI Michigan Genomics Initiative Fixed threshold (5e-06) Huyghe JR et al. 2019 30510241 https://www.ncbi.nlm.nih.gov/pubmed/?term=30510241 85 7e-06 0.0152008 0.0828 0.551 0.525-0.576 OR 2.72 1.56-4.73 2.72 1.56-4.73 2.48 1.64-3.75 2.48 1.64-3.75 1.61 1.17-2.22 1.61 1.17-2.22 1.39 1.09-1.79 1.39 1.09-1.79 1.47 1.23-1.76 1.47 1.23-1.76 1.09 0.848-1.4 0.507 1.11 0.863-1.42 0.424 1.57 1.24-1.98 0.000156 True False False False Both 607 6026 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode153-gwas-catalog-r2019-05-03-x153-p-5e-06-mgi-20200608 prsweb-phecode153-gwas-catalog-r2019-05-03-x153-p-5e-06-mgi-20200608 PRSWEB_PHECODE153_GWAS-Catalog-r2019-05-03-X153_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE153_GWAS-Catalog-r2019-05-03-X153_P_5e-06_MGI_20200608 153 Colorectal cancer Binary 37 unique SNPs MGI Michigan Genomics Initiative Fixed threshold (5e-06) GWAS Catalog (2019-05-03) 17618284;17934461;18372901;19011631;23266556;24737748;25990418;26151821;28960316 https://www.ncbi.nlm.nih.gov/pubmed/?term=17618284+17934461+18372901+19011631+23266556+24737748+25990418+26151821+28960316 26 0.096 0.00472419 0.083 0.515 0.491-0.538 OR 2.05 1.11-3.81 2.05 1.11-3.81 1.45 0.873-2.42 1.45 0.873-2.42 1.01 0.688-1.48 1.01 0.688-1.48 0.909 0.682-1.21 0.909 0.682-1.21 1.09 0.902-1.32 1.09 0.902-1.32 1.3 1.02-1.65 0.0358 1.21 0.951-1.55 0.119 1.27 0.998-1.62 0.0518 False False False False Both 607 6026 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode153-ukbb-saige-hrc-x153-p-5e-06-mgi-20200608 prsweb-phecode153-ukbb-saige-hrc-x153-p-5e-06-mgi-20200608 PRSWEB_PHECODE153_UKBB-SAIGE-HRC-X153_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE153_UKBB-SAIGE-HRC-X153_P_5e-06_MGI_20200608 153 Colorectal cancer Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 30 0.043 0.00560224 0.083 0.518 0.493-0.543 OR 1.55 0.778-3.11 1.55 0.778-3.11 1.45 0.869-2.41 1.45 0.869-2.41 1.46 1.05-2.03 1.46 1.05-2.03 1.22 0.941-1.58 1.22 0.941-1.58 1.14 0.946-1.38 1.14 0.946-1.38 0.88 0.688-1.13 0.309 1.14 0.902-1.44 0.274 1.14 0.907-1.44 0.256 True False False False Both 607 6026 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode153-crc-huyghe-p-5e-07-mgi-20200608 prsweb-phecode153-crc-huyghe-p-5e-07-mgi-20200608 PRSWEB_PHECODE153_CRC-Huyghe_P_5e-07_MGI_20200608 P_5e-07 PRSWEB_PHECODE153_CRC-Huyghe_P_5e-07_MGI_20200608 153 Colorectal cancer Binary Supplementary Tables 11 & 15; Cases: Discovery: 34,869; Follow-up: 23,262; Controls: Discovery: 29,051; Follow-up: 38,296 controls MGI Michigan Genomics Initiative Fixed threshold (5e-07) Huyghe JR et al. 2019 30510241 https://www.ncbi.nlm.nih.gov/pubmed/?term=30510241 81 5.4e-06 0.0156534 0.0828 0.553 0.525-0.577 OR 3.04 1.79-5.17 3.04 1.79-5.17 2.24 1.46-3.44 2.24 1.46-3.44 1.69 1.23-2.31 1.69 1.23-2.31 1.53 1.21-1.95 1.53 1.21-1.95 1.58 1.32-1.89 1.58 1.32-1.89 1.05 0.819-1.35 0.687 1.03 0.803-1.33 0.803 1.63 1.29-2.05 3.39e-05 True False False False Both 607 6026 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode153-gwas-catalog-r2019-05-03-x153-p-5e-07-mgi-20200608 prsweb-phecode153-gwas-catalog-r2019-05-03-x153-p-5e-07-mgi-20200608 PRSWEB_PHECODE153_GWAS-Catalog-r2019-05-03-X153_P_5e-07_MGI_20200608 P_5e-07 PRSWEB_PHECODE153_GWAS-Catalog-r2019-05-03-X153_P_5e-07_MGI_20200608 153 Colorectal cancer Binary 37 unique SNPs MGI Michigan Genomics Initiative Fixed threshold (5e-07) GWAS Catalog (2019-05-03) 17618284;17934461;18372901;19011631;23266556;24737748;25990418;26151821;28960316 https://www.ncbi.nlm.nih.gov/pubmed/?term=17618284+17934461+18372901+19011631+23266556+24737748+25990418+26151821+28960316 22 0.088 0.00468822 0.083 0.515 0.49-0.538 OR 2.04 1.1-3.79 2.04 1.1-3.79 1.37 0.813-2.31 1.37 0.813-2.31 1.04 0.716-1.52 1.04 0.716-1.52 1.15 0.882-1.5 1.15 0.882-1.5 1.1 0.915-1.33 1.1 0.915-1.33 1.04 0.818-1.33 0.734 1.15 0.905-1.45 0.256 1.17 0.926-1.49 0.187 False False False False Both 607 6026 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode153-ukbb-saige-hrc-x153-p-5e-07-mgi-20200608 prsweb-phecode153-ukbb-saige-hrc-x153-p-5e-07-mgi-20200608 PRSWEB_PHECODE153_UKBB-SAIGE-HRC-X153_P_5e-07_MGI_20200608 P_5e-07 PRSWEB_PHECODE153_UKBB-SAIGE-HRC-X153_P_5e-07_MGI_20200608 153 Colorectal cancer Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative Fixed threshold (5e-07) UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 10 0.0062 0.00406733 0.083 0.53 0.504-0.554 OR 1.53 0.764-3.05 1.53 0.764-3.05 1.61 0.991-2.62 1.61 0.991-2.62 1.28 0.904-1.81 1.28 0.904-1.81 1.14 0.875-1.49 1.14 0.875-1.49 1.27 1.06-1.53 1.27 1.06-1.53 1.07 0.834-1.37 0.596 1.21 0.951-1.54 0.121 1.39 1.1-1.76 0.00627 True False False False Both 607 6026 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode153-crc-huyghe-p-5e-09-mgi-20200608 prsweb-phecode153-crc-huyghe-p-5e-09-mgi-20200608 PRSWEB_PHECODE153_CRC-Huyghe_P_5e-09_MGI_20200608 P_5e-09 PRSWEB_PHECODE153_CRC-Huyghe_P_5e-09_MGI_20200608 153 Colorectal cancer Binary Supplementary Tables 11 & 15; Cases: Discovery: 34,869; Follow-up: 23,262; Controls: Discovery: 29,051; Follow-up: 38,296 controls MGI Michigan Genomics Initiative Fixed threshold (5e-09) Huyghe JR et al. 2019 30510241 https://www.ncbi.nlm.nih.gov/pubmed/?term=30510241 56 9.3e-07 0.012687 0.0827 0.559 0.532-0.584 OR 1.89 0.995-3.58 1.89 0.995-3.58 2.41 1.59-3.67 2.41 1.59-3.67 1.8 1.32-2.44 1.8 1.32-2.44 1.49 1.17-1.91 1.49 1.17-1.91 1.47 1.23-1.76 1.47 1.23-1.76 1.02 0.79-1.32 0.878 1.25 0.981-1.6 0.071 1.61 1.27-2.04 6.84e-05 True False False False Both 607 6026 GRCh37/hg19 P<=5e-09 2020-06-08 prsweb-phecode153-gwas-catalog-r2019-05-03-x153-p-5e-09-mgi-20200608 prsweb-phecode153-gwas-catalog-r2019-05-03-x153-p-5e-09-mgi-20200608 PRSWEB_PHECODE153_GWAS-Catalog-r2019-05-03-X153_P_5e-09_MGI_20200608 P_5e-09 PRSWEB_PHECODE153_GWAS-Catalog-r2019-05-03-X153_P_5e-09_MGI_20200608 153 Colorectal cancer Binary 37 unique SNPs MGI Michigan Genomics Initiative Fixed threshold (5e-09) GWAS Catalog (2019-05-03) 17618284;17934461;18372901;19011631;23266556;24737748;25990418;26151821;28960316 https://www.ncbi.nlm.nih.gov/pubmed/?term=17618284+17934461+18372901+19011631+23266556+24737748+25990418+26151821+28960316 12 0.033 0.00326916 0.083 0.521 0.496-0.544 OR 1.39 0.67-2.87 1.39 0.67-2.87 1.36 0.806-2.29 1.36 0.806-2.29 1.18 0.821-1.68 1.18 0.821-1.68 1.27 0.986-1.64 1.27 0.986-1.64 1.27 1.06-1.52 1.27 1.06-1.52 1.07 0.837-1.36 0.598 1.06 0.832-1.36 0.63 1.32 1.05-1.67 0.0188 True False False False Both 607 6026 GRCh37/hg19 P<=5e-09 2020-06-08 prsweb-phecode153-crc-huyghe-p-5e-08-mgi-20200608 prsweb-phecode153-crc-huyghe-p-5e-08-mgi-20200608 PRSWEB_PHECODE153_CRC-Huyghe_P_5e-08_MGI_20200608 P_5e-08 PRSWEB_PHECODE153_CRC-Huyghe_P_5e-08_MGI_20200608 153 Colorectal cancer Binary Supplementary Tables 11 & 15; Cases: Discovery: 34,869; Follow-up: 23,262; Controls: Discovery: 29,051; Follow-up: 38,296 controls MGI Michigan Genomics Initiative GWAS Hits Huyghe JR et al. 2019 30510241 https://www.ncbi.nlm.nih.gov/pubmed/?term=30510241 74 2.1e-05 0.0151591 0.0828 0.55 0.522-0.574 OR 2.2 1.21-4 2.2 1.21-4 2.31 1.51-3.54 2.31 1.51-3.54 1.69 1.24-2.31 1.69 1.24-2.31 1.5 1.18-1.91 1.5 1.18-1.91 1.46 1.22-1.75 1.46 1.22-1.75 0.963 0.746-1.24 0.768 1.18 0.922-1.5 0.192 1.53 1.21-1.93 0.000351 True False False True Both 607 6026 GRCh37/hg19 P<=5e-08 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000367/ScoringFiles/ https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000367/ScoringFiles/ /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE153_CRC-Huyghe_P_5e-08_MGI_20200608/all.tsv /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE153_CRC-Huyghe_P_5e-08_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode153-gwas-catalog-r2019-05-03-x153-p-5e-08-mgi-20200608 prsweb-phecode153-gwas-catalog-r2019-05-03-x153-p-5e-08-mgi-20200608 PRSWEB_PHECODE153_GWAS-Catalog-r2019-05-03-X153_P_5e-08_MGI_20200608 P_5e-08 PRSWEB_PHECODE153_GWAS-Catalog-r2019-05-03-X153_P_5e-08_MGI_20200608 153 Colorectal cancer Binary 37 unique SNPs MGI Michigan Genomics Initiative GWAS Hits GWAS Catalog (2019-05-03) 17618284;17934461;18372901;19011631;23266556;24737748;25990418;26151821;28960316 https://www.ncbi.nlm.nih.gov/pubmed/?term=17618284+17934461+18372901+19011631+23266556+24737748+25990418+26151821+28960316 18 0.058 0.00453584 0.083 0.52 0.495-0.544 OR 1.06 0.467-2.4 1.06 0.467-2.4 0.78 0.4-1.52 0.78 0.4-1.52 1.18 0.824-1.69 1.18 0.824-1.69 1.2 0.924-1.56 1.2 0.924-1.56 1.19 0.99-1.43 1.19 0.99-1.43 1.03 0.803-1.31 0.835 1.2 0.941-1.52 0.143 1.28 1.01-1.62 0.0406 False False False False Both 607 6026 GRCh37/hg19 P<=5e-08 2020-06-08 prsweb-phecode153-20001-1020-pt-mgi-20200608 prsweb-phecode153-20001-1020-pt-mgi-20200608 PRSWEB_PHECODE153_20001-1020_PT_MGI_20200608 P&T PRSWEB_PHECODE153_20001-1020_PT_MGI_20200608 153 Cancer code, self-reported: large bowel cancer/colorectal cancer Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative P&T UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 173 0.077 0.000853913 0.083 0.516 0.493-0.538 OR 1.05 0.464-2.38 1.05 0.464-2.38 1.36 0.805-2.29 1.36 0.805-2.29 1.07 0.735-1.55 1.07 0.735-1.55 1.14 0.876-1.49 1.14 0.876-1.49 1.1 0.914-1.33 1.1 0.914-1.33 1.35 1.06-1.72 0.0136 1.16 0.908-1.49 0.231 1.29 1.01-1.64 0.0416 False False False False Both 607 6026 GRCh37/hg19 P<=9.98e-05 2020-06-08 prsweb-phecode153-crc-huyghe-pt-mgi-20200608 prsweb-phecode153-crc-huyghe-pt-mgi-20200608 PRSWEB_PHECODE153_CRC-Huyghe_PT_MGI_20200608 P&T PRSWEB_PHECODE153_CRC-Huyghe_PT_MGI_20200608 153 Colorectal cancer Binary Supplementary Tables 11 & 15; Cases: Discovery: 34,869; Follow-up: 23,262; Controls: Discovery: 29,051; Follow-up: 38,296 controls MGI Michigan Genomics Initiative P&T Huyghe JR et al. 2019 30510241 https://www.ncbi.nlm.nih.gov/pubmed/?term=30510241 81 5.4e-06 0.0156534 0.0828 0.553 0.525-0.577 OR 3.04 1.79-5.17 3.04 1.79-5.17 2.24 1.46-3.44 2.24 1.46-3.44 1.69 1.23-2.31 1.69 1.23-2.31 1.53 1.21-1.95 1.53 1.21-1.95 1.58 1.32-1.89 1.58 1.32-1.89 1.05 0.819-1.35 0.687 1.03 0.803-1.33 0.803 1.63 1.29-2.05 3.39e-05 True False False True Both 607 6026 GRCh37/hg19 P<=3.98e-07 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000369/ScoringFiles/ https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000369/ScoringFiles/ /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE153_CRC-Huyghe_PT_MGI_20200608/all.tsv /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE153_CRC-Huyghe_PT_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode153-gwas-catalog-r2019-05-03-x153-pt-mgi-20200608 prsweb-phecode153-gwas-catalog-r2019-05-03-x153-pt-mgi-20200608 PRSWEB_PHECODE153_GWAS-Catalog-r2019-05-03-X153_PT_MGI_20200608 P&T PRSWEB_PHECODE153_GWAS-Catalog-r2019-05-03-X153_PT_MGI_20200608 153 Colorectal cancer Binary 37 unique SNPs MGI Michigan Genomics Initiative P&T GWAS Catalog (2019-05-03) 17618284;17934461;18372901;19011631;23266556;24737748;25990418;26151821;28960316 https://www.ncbi.nlm.nih.gov/pubmed/?term=17618284+17934461+18372901+19011631+23266556+24737748+25990418+26151821+28960316 27 0.095 0.00481477 0.083 0.516 0.492-0.538 OR 1.89 0.998-3.59 1.89 0.998-3.59 1.46 0.874-2.42 1.46 0.874-2.42 1.05 0.717-1.52 1.05 0.717-1.52 0.909 0.681-1.21 0.909 0.681-1.21 1.1 0.909-1.33 1.1 0.909-1.33 1.29 1.01-1.64 0.0405 1.22 0.952-1.55 0.117 1.28 1-1.63 0.0463 False False False False Both 607 6026 GRCh37/hg19 P<=7e-06 2020-06-08 prsweb-phecode153-ukbb-saige-hrc-x153-pt-mgi-20200608 prsweb-phecode153-ukbb-saige-hrc-x153-pt-mgi-20200608 PRSWEB_PHECODE153_UKBB-SAIGE-HRC-X153_PT_MGI_20200608 P&T PRSWEB_PHECODE153_UKBB-SAIGE-HRC-X153_PT_MGI_20200608 153 Colorectal cancer Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative P&T UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 41 0.039 0.00630203 0.083 0.517 0.493-0.541 OR 1.88 0.99-3.55 1.88 0.99-3.55 1.6 0.986-2.61 1.6 0.986-2.61 1.53 1.11-2.12 1.53 1.11-2.12 1.39 1.09-1.79 1.39 1.09-1.79 1.08 0.891-1.3 1.08 0.891-1.3 1.2 0.943-1.54 0.137 1.34 1.06-1.71 0.0162 1.27 0.993-1.61 0.0575 True False False True Both 607 6026 GRCh37/hg19 P<=7.94e-06 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000374/ScoringFiles/ https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000374/ScoringFiles/ /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE153_UKBB-SAIGE-HRC-X153_PT_MGI_20200608/all.tsv /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE153_UKBB-SAIGE-HRC-X153_PT_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode153-20001-1020-prs-cs-mgi-20200608 prsweb-phecode153-20001-1020-prs-cs-mgi-20200608 PRSWEB_PHECODE153_20001-1020_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE153_20001-1020_PRS-CS_MGI_20200608 153 Cancer code, self-reported: large bowel cancer/colorectal cancer Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative PRS-CS UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1072047 0.075 0.00091546 0.083 0.523 0.499-0.547 OR 0.717 0.273-1.88 0.717 0.273-1.88 0.855 0.452-1.62 0.855 0.452-1.62 1 0.685-1.47 1 0.685-1.47 1.12 0.854-1.46 1.12 0.854-1.46 1.17 0.969-1.41 1.17 0.969-1.41 1.23 0.961-1.57 0.101 1.24 0.972-1.58 0.0827 1.34 1.06-1.71 0.0164 False False False False Both 607 6026 GRCh37/hg19 auto 2020-06-08 prsweb-phecode153-ukbb-saige-hrc-x153-prs-cs-mgi-20200608 prsweb-phecode153-ukbb-saige-hrc-x153-prs-cs-mgi-20200608 PRSWEB_PHECODE153_UKBB-SAIGE-HRC-X153_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE153_UKBB-SAIGE-HRC-X153_PRS-CS_MGI_20200608 153 Colorectal cancer Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative PRS-CS UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1119238 5.5e-05 0.00596938 0.0829 0.548 0.523-0.572 OR 1.71 0.882-3.33 1.71 0.882-3.33 1.62 0.995-2.64 1.62 0.995-2.64 1.76 1.29-2.39 1.76 1.29-2.39 1.55 1.22-1.97 1.55 1.22-1.97 1.5 1.25-1.79 1.5 1.25-1.79 1.03 0.804-1.32 0.81 1.04 0.815-1.34 0.73 1.51 1.2-1.91 0.000402 True False False True Both 607 6026 GRCh37/hg19 auto https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000373/ScoringFiles/ https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000373/ScoringFiles/ /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE153_UKBB-SAIGE-HRC-X153_PRS-CS_MGI_20200608/all.tsv /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE153_UKBB-SAIGE-HRC-X153_PRS-CS_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode153-ukbb-saige-hrc-x153-lassosum-mgi-20200608 prsweb-phecode153-ukbb-saige-hrc-x153-lassosum-mgi-20200608 PRSWEB_PHECODE153_UKBB-SAIGE-HRC-X153_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE153_UKBB-SAIGE-HRC-X153_LASSOSUM_MGI_20200608 153 Colorectal cancer Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative lassosum UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 370 0.012 0.00380963 0.083 0.53 0.503-0.555 OR 2.76 1.59-4.81 2.76 1.59-4.81 1.91 1.21-3.02 1.91 1.21-3.02 1.57 1.14-2.17 1.57 1.14-2.17 1.27 0.986-1.64 1.27 0.986-1.64 1.3 1.09-1.56 1.3 1.09-1.56 1.01 0.787-1.28 0.965 1.06 0.831-1.35 0.64 1.33 1.06-1.68 0.0152 True False False True Both 607 6026 GRCh37/hg19 s=0.5;Lambda=0.02976 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000375/ScoringFiles/ https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000375/ScoringFiles/ /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE153_UKBB-SAIGE-HRC-X153_LASSOSUM_MGI_20200608/all.tsv /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE153_UKBB-SAIGE-HRC-X153_LASSOSUM_MGI_20200608/exclusion.tsv 2020-06-08