prs_id slug legacy_id legacy_model prswebprefix trait_code trait_name trait_type description cohort cohort_label method gwas_source reference_label reference_url snp_count p_value pseudo_r2 brier_score mse aauc aauc_ci effect_metric top_effect_1 top_effect_1_ci top_or_1 top_or_1_ci top_effect_2 top_effect_2_ci top_or_2 top_or_2_ci top_effect_5 top_effect_5_ci top_or_5 top_or_5_ci top_effect_10 top_effect_10_ci top_or_10 top_or_10_ci top_effect_25 top_effect_25_ci top_or_25 top_or_25_ci q1_vs_q2_effect q1_vs_q2_effect_ci q1_vs_q2_p_value q1_vs_q3_effect q1_vs_q3_effect_ci q1_vs_q3_p_value q1_vs_q4_effect q1_vs_q4_effect_ci q1_vs_q4_p_value nominally_significant reversed_effect_warning underpowered_warning upload_to_portal sex cases controls genome_build tuning_parameter weights_external_url weights_url phewas_download_url exclusion_download_url last_updated prsweb-phecode172-2-20001-1060-p-5e-05-mgi-20200608 prsweb-phecode172-2-20001-1060-p-5e-05-mgi-20200608 PRSWEB_PHECODE172.2_20001-1060_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE172.2_20001-1060_P_5e-05_MGI_20200608 172.2 Cancer code, self-reported: non-melanoma skin cancer Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 112 0.51 7.0793e-05 0.139 0.501 0.49-0.513 OR 0.868 0.565-1.33 0.868 0.565-1.33 0.942 0.703-1.26 0.942 0.703-1.26 0.971 0.803-1.18 0.971 0.803-1.18 0.972 0.846-1.12 0.972 0.846-1.12 1.02 0.928-1.12 1.02 0.928-1.12 1.08 0.956-1.21 0.225 1.06 0.944-1.2 0.314 1.07 0.947-1.2 0.288 False False False False Both 2954 12944 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode172-2-c3-other-skin-p-5e-05-mgi-20200608 prsweb-phecode172-2-c3-other-skin-p-5e-05-mgi-20200608 PRSWEB_PHECODE172.2_C3-OTHER-SKIN_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE172.2_C3-OTHER-SKIN_P_5e-05_MGI_20200608 172.2 Other malignant neoplasms of skin Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 446 1.6e-45 0.0246508 0.137 0.584 0.572-0.597 OR 2.7 1.99-3.66 2.7 1.99-3.66 2.31 1.84-2.89 2.31 1.84-2.89 2.02 1.73-2.36 2.02 1.73-2.36 1.9 1.69-2.14 1.9 1.69-2.14 1.73 1.58-1.89 1.73 1.58-1.89 1.2 1.05-1.37 0.00569 1.43 1.26-1.62 2.67e-08 2.1 1.86-2.37 1.79e-33 True False False False Both 2954 12944 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode172-2-c44-p-5e-05-mgi-20200608 prsweb-phecode172-2-c44-p-5e-05-mgi-20200608 PRSWEB_PHECODE172.2_C44_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE172.2_C44_P_5e-05_MGI_20200608 172.2 Diagnoses - main ICD10: C44 Other malignant neoplasms of skin Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 321 3.7e-43 0.0232486 0.137 0.581 0.569-0.593 OR 2.05 1.46-2.86 2.05 1.46-2.86 1.99 1.57-2.52 1.99 1.57-2.52 1.91 1.63-2.23 1.91 1.63-2.23 1.84 1.63-2.07 1.84 1.63-2.07 1.67 1.53-1.83 1.67 1.53-1.83 1.28 1.13-1.46 0.000173 1.52 1.34-1.73 7.94e-11 2.12 1.87-2.39 6.27e-34 True False False False Both 2954 12944 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode172-2-ukbb-saige-hrc-x172-2-p-5e-05-mgi-20200608 prsweb-phecode172-2-ukbb-saige-hrc-x172-2-p-5e-05-mgi-20200608 PRSWEB_PHECODE172.2_UKBB-SAIGE-HRC-X172.2_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE172.2_UKBB-SAIGE-HRC-X172.2_P_5e-05_MGI_20200608 172.2 Other non-epithelial cancer of skin Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 367 1.8e-51 0.0267679 0.137 0.587 0.576-0.599 OR 3 2.23-4.04 3 2.23-4.04 2.46 1.96-3.08 2.46 1.96-3.08 2.27 1.95-2.63 2.27 1.95-2.63 2.09 1.86-2.35 2.09 1.86-2.35 1.73 1.58-1.89 1.73 1.58-1.89 1.28 1.12-1.46 0.000228 1.5 1.32-1.7 4.44e-10 2.19 1.94-2.48 1.44e-36 True False False False Both 2954 12944 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode172-2-20001-1060-p-5e-06-mgi-20200608 prsweb-phecode172-2-20001-1060-p-5e-06-mgi-20200608 PRSWEB_PHECODE172.2_20001-1060_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE172.2_20001-1060_P_5e-06_MGI_20200608 172.2 Cancer code, self-reported: non-melanoma skin cancer Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 18 0.38 0.000107167 0.139 0.494 0.483-0.506 OR 1.6 1.12-2.28 1.6 1.12-2.28 1.26 0.955-1.66 1.26 0.955-1.66 1.15 0.959-1.38 1.15 0.959-1.38 0.97 0.844-1.11 0.97 0.844-1.11 1.05 0.959-1.16 1.05 0.959-1.16 1.03 0.917-1.16 0.607 1.02 0.908-1.15 0.723 1.07 0.954-1.2 0.243 False False False False Both 2954 12944 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode172-2-c3-other-skin-p-5e-06-mgi-20200608 prsweb-phecode172-2-c3-other-skin-p-5e-06-mgi-20200608 PRSWEB_PHECODE172.2_C3-OTHER-SKIN_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE172.2_C3-OTHER-SKIN_P_5e-06_MGI_20200608 172.2 Other malignant neoplasms of skin Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 207 6.4e-50 0.0228129 0.137 0.588 0.576-0.601 OR 2.63 1.93-3.59 2.63 1.93-3.59 2.27 1.8-2.86 2.27 1.8-2.86 2.11 1.81-2.45 2.11 1.81-2.45 1.95 1.73-2.19 1.95 1.73-2.19 1.77 1.62-1.93 1.77 1.62-1.93 1.33 1.17-1.52 1.63e-05 1.53 1.35-1.74 1e-10 2.29 2.02-2.58 3.05e-40 True False False False Both 2954 12944 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode172-2-c44-p-5e-06-mgi-20200608 prsweb-phecode172-2-c44-p-5e-06-mgi-20200608 PRSWEB_PHECODE172.2_C44_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE172.2_C44_P_5e-06_MGI_20200608 172.2 Diagnoses - main ICD10: C44 Other malignant neoplasms of skin Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 131 5.9e-46 0.0206722 0.137 0.582 0.569-0.594 OR 2.38 1.73-3.26 2.38 1.73-3.26 2.48 1.98-3.11 2.48 1.98-3.11 2.06 1.77-2.41 2.06 1.77-2.41 1.84 1.64-2.07 1.84 1.64-2.07 1.69 1.55-1.85 1.69 1.55-1.85 1.22 1.07-1.39 0.00308 1.47 1.29-1.66 2.13e-09 2.09 1.85-2.35 3.79e-33 True False False False Both 2954 12944 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode172-2-ukbb-saige-hrc-x172-2-p-5e-06-mgi-20200608 prsweb-phecode172-2-ukbb-saige-hrc-x172-2-p-5e-06-mgi-20200608 PRSWEB_PHECODE172.2_UKBB-SAIGE-HRC-X172.2_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE172.2_UKBB-SAIGE-HRC-X172.2_P_5e-06_MGI_20200608 172.2 Other non-epithelial cancer of skin Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 160 1.2e-55 0.0259604 0.136 0.59 0.579-0.602 OR 2.87 2.12-3.89 2.87 2.12-3.89 2.54 2.03-3.19 2.54 2.03-3.19 2.2 1.89-2.56 2.2 1.89-2.56 1.98 1.77-2.23 1.98 1.77-2.23 1.79 1.64-1.95 1.79 1.64-1.95 1.39 1.22-1.59 6.84e-07 1.46 1.28-1.66 9.31e-09 2.3 2.04-2.6 1.65e-40 True False False False Both 2954 12944 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode172-2-c3-other-skin-p-5e-07-mgi-20200608 prsweb-phecode172-2-c3-other-skin-p-5e-07-mgi-20200608 PRSWEB_PHECODE172.2_C3-OTHER-SKIN_P_5e-07_MGI_20200608 P_5e-07 PRSWEB_PHECODE172.2_C3-OTHER-SKIN_P_5e-07_MGI_20200608 172.2 Other malignant neoplasms of skin Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-07) UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 139 7.1e-50 0.0215929 0.137 0.586 0.574-0.599 OR 2.78 2.05-3.77 2.78 2.05-3.77 2.38 1.9-2.99 2.38 1.9-2.99 2.16 1.86-2.52 2.16 1.86-2.52 1.86 1.65-2.09 1.86 1.65-2.09 1.74 1.59-1.9 1.74 1.59-1.9 1.19 1.04-1.36 0.00989 1.51 1.33-1.71 2.11e-10 2.16 1.91-2.43 1.02e-35 True False False False Both 2954 12944 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode172-2-c44-p-5e-07-mgi-20200608 prsweb-phecode172-2-c44-p-5e-07-mgi-20200608 PRSWEB_PHECODE172.2_C44_P_5e-07_MGI_20200608 P_5e-07 PRSWEB_PHECODE172.2_C44_P_5e-07_MGI_20200608 172.2 Diagnoses - main ICD10: C44 Other malignant neoplasms of skin Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-07) UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 89 3.5e-46 0.0200985 0.137 0.581 0.569-0.594 OR 2.37 1.72-3.28 2.37 1.72-3.28 2.49 1.99-3.12 2.49 1.99-3.12 2.01 1.72-2.35 2.01 1.72-2.35 1.87 1.67-2.11 1.87 1.67-2.11 1.71 1.56-1.87 1.71 1.56-1.87 1.17 1.02-1.33 0.0202 1.41 1.24-1.6 9.93e-08 2.04 1.81-2.31 1.27e-31 True False False False Both 2954 12944 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode172-2-ukbb-saige-hrc-x172-2-p-5e-07-mgi-20200608 prsweb-phecode172-2-ukbb-saige-hrc-x172-2-p-5e-07-mgi-20200608 PRSWEB_PHECODE172.2_UKBB-SAIGE-HRC-X172.2_P_5e-07_MGI_20200608 P_5e-07 PRSWEB_PHECODE172.2_UKBB-SAIGE-HRC-X172.2_P_5e-07_MGI_20200608 172.2 Other non-epithelial cancer of skin Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative Fixed threshold (5e-07) UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 109 6.9e-55 0.0235709 0.136 0.589 0.577-0.601 OR 2.75 2.02-3.75 2.75 2.02-3.75 2.52 2.01-3.16 2.52 2.01-3.16 2.28 1.96-2.65 2.28 1.96-2.65 1.96 1.75-2.2 1.96 1.75-2.2 1.77 1.62-1.93 1.77 1.62-1.93 1.38 1.21-1.57 2e-06 1.55 1.36-1.76 4.38e-11 2.32 2.05-2.63 6.89e-41 True False False False Both 2954 12944 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode172-2-c3-other-skin-p-5e-09-mgi-20200608 prsweb-phecode172-2-c3-other-skin-p-5e-09-mgi-20200608 PRSWEB_PHECODE172.2_C3-OTHER-SKIN_P_5e-09_MGI_20200608 P_5e-09 PRSWEB_PHECODE172.2_C3-OTHER-SKIN_P_5e-09_MGI_20200608 172.2 Other malignant neoplasms of skin Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-09) UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 85 2.2e-48 0.0205517 0.137 0.585 0.573-0.598 OR 2.82 2.07-3.83 2.82 2.07-3.83 2.33 1.84-2.93 2.33 1.84-2.93 2.06 1.77-2.41 2.06 1.77-2.41 1.83 1.62-2.06 1.83 1.62-2.06 1.73 1.58-1.89 1.73 1.58-1.89 1.21 1.06-1.38 0.00469 1.58 1.39-1.79 1.71e-12 2.2 1.95-2.48 4.7e-37 True False False False Both 2954 12944 GRCh37/hg19 P<=5e-09 2020-06-08 prsweb-phecode172-2-c44-p-5e-09-mgi-20200608 prsweb-phecode172-2-c44-p-5e-09-mgi-20200608 PRSWEB_PHECODE172.2_C44_P_5e-09_MGI_20200608 P_5e-09 PRSWEB_PHECODE172.2_C44_P_5e-09_MGI_20200608 172.2 Diagnoses - main ICD10: C44 Other malignant neoplasms of skin Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-09) UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 51 1.5e-42 0.0177433 0.137 0.574 0.562-0.587 OR 2.07 1.48-2.89 2.07 1.48-2.89 2.24 1.77-2.84 2.24 1.77-2.84 2.1 1.8-2.45 2.1 1.8-2.45 1.73 1.53-1.95 1.73 1.53-1.95 1.65 1.51-1.8 1.65 1.51-1.8 1.28 1.12-1.46 0.00025 1.56 1.37-1.77 8.9e-12 2.1 1.86-2.38 6.25e-33 True False False False Both 2954 12944 GRCh37/hg19 P<=5e-09 2020-06-08 prsweb-phecode172-2-ukbb-saige-hrc-x172-2-p-5e-09-mgi-20200608 prsweb-phecode172-2-ukbb-saige-hrc-x172-2-p-5e-09-mgi-20200608 PRSWEB_PHECODE172.2_UKBB-SAIGE-HRC-X172.2_P_5e-09_MGI_20200608 P_5e-09 PRSWEB_PHECODE172.2_UKBB-SAIGE-HRC-X172.2_P_5e-09_MGI_20200608 172.2 Other non-epithelial cancer of skin Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative Fixed threshold (5e-09) UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 61 7.2e-53 0.020426 0.137 0.584 0.572-0.596 OR 3.09 2.28-4.19 3.09 2.28-4.19 2.68 2.14-3.34 2.68 2.14-3.34 2.21 1.9-2.57 2.21 1.9-2.57 1.96 1.75-2.2 1.96 1.75-2.2 1.75 1.6-1.91 1.75 1.6-1.91 1.25 1.09-1.42 0.00112 1.54 1.36-1.75 2.63e-11 2.23 1.97-2.51 7.63e-38 True False False False Both 2954 12944 GRCh37/hg19 P<=5e-09 2020-06-08 prsweb-phecode172-2-c3-other-skin-p-5e-08-mgi-20200608 prsweb-phecode172-2-c3-other-skin-p-5e-08-mgi-20200608 PRSWEB_PHECODE172.2_C3-OTHER-SKIN_P_5e-08_MGI_20200608 P_5e-08 PRSWEB_PHECODE172.2_C3-OTHER-SKIN_P_5e-08_MGI_20200608 172.2 Other malignant neoplasms of skin Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative GWAS Hits UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 108 1e-47 0.0199202 0.137 0.584 0.572-0.598 OR 2.73 2.01-3.72 2.73 2.01-3.72 2.54 2.02-3.19 2.54 2.02-3.19 2.01 1.72-2.35 2.01 1.72-2.35 1.91 1.69-2.14 1.91 1.69-2.14 1.68 1.54-1.84 1.68 1.54-1.84 1.19 1.04-1.35 0.0105 1.51 1.33-1.71 1.48e-10 2.09 1.85-2.36 8e-33 True False False True Both 2954 12944 GRCh37/hg19 P<=5e-08 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000433/ScoringFiles/ https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000433/ScoringFiles/ /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE172.2_C3-OTHER-SKIN_P_5e-08_MGI_20200608/all.tsv /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE172.2_C3-OTHER-SKIN_P_5e-08_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode172-2-c44-p-5e-08-mgi-20200608 prsweb-phecode172-2-c44-p-5e-08-mgi-20200608 PRSWEB_PHECODE172.2_C44_P_5e-08_MGI_20200608 P_5e-08 PRSWEB_PHECODE172.2_C44_P_5e-08_MGI_20200608 172.2 Diagnoses - main ICD10: C44 Other malignant neoplasms of skin Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative GWAS Hits UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 63 1.5e-45 0.0198259 0.137 0.579 0.566-0.592 OR 2.21 1.6-3.06 2.21 1.6-3.06 2.07 1.63-2.63 2.07 1.63-2.63 2.17 1.86-2.53 2.17 1.86-2.53 1.75 1.56-1.98 1.75 1.56-1.98 1.7 1.55-1.86 1.7 1.55-1.86 1.21 1.06-1.37 0.00544 1.49 1.32-1.69 4.8e-10 2.09 1.86-2.36 5.54e-33 True False False True Both 2954 12944 GRCh37/hg19 P<=5e-08 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000437/ScoringFiles/ https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000437/ScoringFiles/ /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE172.2_C44_P_5e-08_MGI_20200608/all.tsv /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE172.2_C44_P_5e-08_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode172-2-ukbb-saige-hrc-x172-2-p-5e-08-mgi-20200608 prsweb-phecode172-2-ukbb-saige-hrc-x172-2-p-5e-08-mgi-20200608 PRSWEB_PHECODE172.2_UKBB-SAIGE-HRC-X172.2_P_5e-08_MGI_20200608 P_5e-08 PRSWEB_PHECODE172.2_UKBB-SAIGE-HRC-X172.2_P_5e-08_MGI_20200608 172.2 Other non-epithelial cancer of skin Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative GWAS Hits UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 77 2.2e-53 0.0202603 0.136 0.586 0.574-0.599 OR 2.65 1.94-3.62 2.65 1.94-3.62 2.74 2.2-3.42 2.74 2.2-3.42 2.15 1.85-2.51 2.15 1.85-2.51 1.98 1.76-2.22 1.98 1.76-2.22 1.78 1.63-1.94 1.78 1.63-1.94 1.21 1.06-1.39 0.00418 1.54 1.36-1.75 2.2e-11 2.24 1.98-2.53 2.51e-38 True False False True Both 2954 12944 GRCh37/hg19 P<=5e-08 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000441/ScoringFiles/ https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000441/ScoringFiles/ /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE172.2_UKBB-SAIGE-HRC-X172.2_P_5e-08_MGI_20200608/all.tsv /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE172.2_UKBB-SAIGE-HRC-X172.2_P_5e-08_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode172-2-20001-1060-pt-mgi-20200608 prsweb-phecode172-2-20001-1060-pt-mgi-20200608 PRSWEB_PHECODE172.2_20001-1060_PT_MGI_20200608 P&T PRSWEB_PHECODE172.2_20001-1060_PT_MGI_20200608 172.2 Cancer code, self-reported: non-melanoma skin cancer Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative P&T UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 177 0.55 0.000765815 0.139 0.5 0.489-0.512 OR 1.12 0.756-1.65 1.12 0.756-1.65 1.05 0.786-1.4 1.05 0.786-1.4 0.979 0.807-1.19 0.979 0.807-1.19 0.928 0.805-1.07 0.928 0.805-1.07 1.05 0.951-1.15 1.05 0.951-1.15 1.11 0.986-1.25 0.0849 1.05 0.935-1.19 0.391 1.1 0.98-1.24 0.103 False False False False Both 2954 12944 GRCh37/hg19 P<=9.97e-05 2020-06-08 prsweb-phecode172-2-c3-other-skin-pt-mgi-20200608 prsweb-phecode172-2-c3-other-skin-pt-mgi-20200608 PRSWEB_PHECODE172.2_C3-OTHER-SKIN_PT_MGI_20200608 P&T PRSWEB_PHECODE172.2_C3-OTHER-SKIN_PT_MGI_20200608 172.2 Other malignant neoplasms of skin Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative P&T UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 446 1.6e-45 0.0246508 0.137 0.584 0.572-0.597 OR 2.7 1.99-3.66 2.7 1.99-3.66 2.31 1.84-2.89 2.31 1.84-2.89 2.02 1.73-2.36 2.02 1.73-2.36 1.9 1.69-2.14 1.9 1.69-2.14 1.73 1.58-1.89 1.73 1.58-1.89 1.2 1.05-1.37 0.00569 1.43 1.26-1.62 2.67e-08 2.1 1.86-2.37 1.79e-33 True False False True Both 2954 12944 GRCh37/hg19 P<=5e-05 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000435/ScoringFiles/ https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000435/ScoringFiles/ /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE172.2_C3-OTHER-SKIN_PT_MGI_20200608/all.tsv /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE172.2_C3-OTHER-SKIN_PT_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode172-2-c44-pt-mgi-20200608 prsweb-phecode172-2-c44-pt-mgi-20200608 PRSWEB_PHECODE172.2_C44_PT_MGI_20200608 P&T PRSWEB_PHECODE172.2_C44_PT_MGI_20200608 172.2 Diagnoses - main ICD10: C44 Other malignant neoplasms of skin Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative P&T UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 467 1.3e-43 0.0239255 0.137 0.583 0.57-0.595 OR 2.17 1.57-3.01 2.17 1.57-3.01 1.98 1.56-2.51 1.98 1.56-2.51 1.93 1.65-2.26 1.93 1.65-2.26 1.85 1.65-2.09 1.85 1.65-2.09 1.69 1.55-1.85 1.69 1.55-1.85 1.31 1.15-1.49 6.54e-05 1.52 1.34-1.72 1.28e-10 2.17 1.92-2.45 1.43e-35 True False False True Both 2954 12944 GRCh37/hg19 P<=9.99e-05 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000439/ScoringFiles/ https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000439/ScoringFiles/ /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE172.2_C44_PT_MGI_20200608/all.tsv /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE172.2_C44_PT_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode172-2-ukbb-saige-hrc-x172-2-pt-mgi-20200608 prsweb-phecode172-2-ukbb-saige-hrc-x172-2-pt-mgi-20200608 PRSWEB_PHECODE172.2_UKBB-SAIGE-HRC-X172.2_PT_MGI_20200608 P&T PRSWEB_PHECODE172.2_UKBB-SAIGE-HRC-X172.2_PT_MGI_20200608 172.2 Other non-epithelial cancer of skin Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative P&T UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 177 4.3e-57 0.0272869 0.136 0.591 0.579-0.603 OR 2.89 2.14-3.92 2.89 2.14-3.92 2.74 2.2-3.42 2.74 2.2-3.42 2.21 1.9-2.57 2.21 1.9-2.57 2.04 1.82-2.29 2.04 1.82-2.29 1.75 1.6-1.92 1.75 1.6-1.92 1.39 1.22-1.58 9.45e-07 1.52 1.33-1.73 2.65e-10 2.31 2.04-2.61 1.74e-40 True False False True Both 2954 12944 GRCh37/hg19 P<=7.94e-06 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000443/ScoringFiles/ https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000443/ScoringFiles/ /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE172.2_UKBB-SAIGE-HRC-X172.2_PT_MGI_20200608/all.tsv /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE172.2_UKBB-SAIGE-HRC-X172.2_PT_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode172-2-20001-1060-prs-cs-mgi-20200608 prsweb-phecode172-2-20001-1060-prs-cs-mgi-20200608 PRSWEB_PHECODE172.2_20001-1060_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE172.2_20001-1060_PRS-CS_MGI_20200608 172.2 Cancer code, self-reported: non-melanoma skin cancer Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative PRS-CS UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1075656 0.081 0.00194814 0.139 0.509 0.497-0.522 OR 1.32 0.898-1.93 1.32 0.898-1.93 1.16 0.871-1.53 1.16 0.871-1.53 1.18 0.987-1.42 1.18 0.987-1.42 1.21 1.06-1.38 1.21 1.06-1.38 1.08 0.983-1.19 1.08 0.983-1.19 1.06 0.943-1.2 0.323 1.05 0.928-1.18 0.46 1.11 0.992-1.25 0.0683 False False False False Both 2954 12944 GRCh37/hg19 auto 2020-06-08 prsweb-phecode172-2-c3-other-skin-prs-cs-mgi-20200608 prsweb-phecode172-2-c3-other-skin-prs-cs-mgi-20200608 PRSWEB_PHECODE172.2_C3-OTHER-SKIN_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE172.2_C3-OTHER-SKIN_PRS-CS_MGI_20200608 172.2 Other malignant neoplasms of skin Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative PRS-CS UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1111490 1.1e-45 0.0281502 0.137 0.586 0.573-0.598 OR 1.99 1.43-2.78 1.99 1.43-2.78 1.87 1.46-2.38 1.87 1.46-2.38 1.79 1.52-2.1 1.79 1.52-2.1 1.77 1.57-1.99 1.77 1.57-1.99 1.81 1.66-1.98 1.81 1.66-1.98 1.38 1.21-1.57 1.28e-06 1.43 1.26-1.63 4.82e-08 2.33 2.06-2.64 7.38e-42 True False False True Both 2954 12944 GRCh37/hg19 auto https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000434/ScoringFiles/ https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000434/ScoringFiles/ /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE172.2_C3-OTHER-SKIN_PRS-CS_MGI_20200608/all.tsv /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE172.2_C3-OTHER-SKIN_PRS-CS_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode172-2-c44-prs-cs-mgi-20200608 prsweb-phecode172-2-c44-prs-cs-mgi-20200608 PRSWEB_PHECODE172.2_C44_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE172.2_C44_PRS-CS_MGI_20200608 172.2 Diagnoses - main ICD10: C44 Other malignant neoplasms of skin Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative PRS-CS UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1111490 6.6e-36 0.0182478 0.137 0.575 0.562-0.587 OR 1.79 1.28-2.51 1.79 1.28-2.51 1.8 1.41-2.29 1.8 1.41-2.29 1.82 1.56-2.14 1.82 1.56-2.14 1.71 1.52-1.93 1.71 1.52-1.93 1.66 1.52-1.81 1.66 1.52-1.81 1.15 1.01-1.31 0.0346 1.4 1.23-1.59 1.63e-07 1.96 1.74-2.21 1.98e-28 True False False True Both 2954 12944 GRCh37/hg19 auto https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000438/ScoringFiles/ https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000438/ScoringFiles/ /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE172.2_C44_PRS-CS_MGI_20200608/all.tsv /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE172.2_C44_PRS-CS_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode172-2-ukbb-saige-hrc-x172-2-prs-cs-mgi-20200608 prsweb-phecode172-2-ukbb-saige-hrc-x172-2-prs-cs-mgi-20200608 PRSWEB_PHECODE172.2_UKBB-SAIGE-HRC-X172.2_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE172.2_UKBB-SAIGE-HRC-X172.2_PRS-CS_MGI_20200608 172.2 Other non-epithelial cancer of skin Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative PRS-CS UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1119238 6.7e-45 0.022207 0.137 0.584 0.572-0.595 OR 2.35 1.71-3.22 2.35 1.71-3.22 2.32 1.84-2.92 2.32 1.84-2.92 1.98 1.7-2.32 1.98 1.7-2.32 1.79 1.59-2.02 1.79 1.59-2.02 1.7 1.56-1.86 1.7 1.56-1.86 1.33 1.17-1.52 1.75e-05 1.54 1.36-1.75 3.44e-11 2.19 1.94-2.48 3.53e-36 True False False True Both 2954 12944 GRCh37/hg19 auto https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000442/ScoringFiles/ https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000442/ScoringFiles/ /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE172.2_UKBB-SAIGE-HRC-X172.2_PRS-CS_MGI_20200608/all.tsv /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE172.2_UKBB-SAIGE-HRC-X172.2_PRS-CS_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode172-2-20001-1060-lassosum-mgi-20200608 prsweb-phecode172-2-20001-1060-lassosum-mgi-20200608 PRSWEB_PHECODE172.2_20001-1060_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE172.2_20001-1060_LASSOSUM_MGI_20200608 172.2 Cancer code, self-reported: non-melanoma skin cancer Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative lassosum UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 4882215 0.17 0.00131817 0.139 0.509 0.497-0.521 OR 0.944 0.61-1.46 0.944 0.61-1.46 0.996 0.736-1.35 0.996 0.736-1.35 1.07 0.886-1.29 1.07 0.886-1.29 1.01 0.883-1.17 1.01 0.883-1.17 1.04 0.948-1.15 1.04 0.948-1.15 1.02 0.907-1.15 0.727 1.09 0.966-1.22 0.168 1.08 0.961-1.22 0.196 False False False False Both 2954 12944 GRCh37/hg19 s=1;Lambda=0.001 2020-06-08 prsweb-phecode172-2-c3-other-skin-lassosum-mgi-20200608 prsweb-phecode172-2-c3-other-skin-lassosum-mgi-20200608 PRSWEB_PHECODE172.2_C3-OTHER-SKIN_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE172.2_C3-OTHER-SKIN_LASSOSUM_MGI_20200608 172.2 Other malignant neoplasms of skin Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative lassosum UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 16626 3.2e-46 0.0257042 0.137 0.584 0.571-0.596 OR 2.22 1.61-3.06 2.22 1.61-3.06 2.15 1.7-2.71 2.15 1.7-2.71 2.08 1.78-2.43 2.08 1.78-2.43 1.98 1.76-2.23 1.98 1.76-2.23 1.71 1.56-1.87 1.71 1.56-1.87 1.19 1.05-1.36 0.00886 1.54 1.35-1.74 2.51e-11 2.11 1.87-2.38 7.04e-34 True False False True Both 2954 12944 GRCh37/hg19 s=0.2;Lambda=0.01129 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000436/ScoringFiles/ https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000436/ScoringFiles/ /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE172.2_C3-OTHER-SKIN_LASSOSUM_MGI_20200608/all.tsv /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE172.2_C3-OTHER-SKIN_LASSOSUM_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode172-2-c44-lassosum-mgi-20200608 prsweb-phecode172-2-c44-lassosum-mgi-20200608 PRSWEB_PHECODE172.2_C44_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE172.2_C44_LASSOSUM_MGI_20200608 172.2 Diagnoses - main ICD10: C44 Other malignant neoplasms of skin Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative lassosum UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 2111 1.6e-44 0.0210061 0.137 0.581 0.569-0.592 OR 2.55 1.87-3.46 2.55 1.87-3.46 2.27 1.81-2.85 2.27 1.81-2.85 2.03 1.74-2.37 2.03 1.74-2.37 1.79 1.58-2.01 1.79 1.58-2.01 1.72 1.57-1.88 1.72 1.57-1.88 1.36 1.19-1.55 3.75e-06 1.49 1.31-1.69 1.01e-09 2.22 1.96-2.51 3.32e-37 True False False True Both 2954 12944 GRCh37/hg19 s=0.2;Lambda=0.01833 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000440/ScoringFiles/ https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000440/ScoringFiles/ /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE172.2_C44_LASSOSUM_MGI_20200608/all.tsv /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE172.2_C44_LASSOSUM_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode172-2-ukbb-saige-hrc-x172-2-lassosum-mgi-20200608 prsweb-phecode172-2-ukbb-saige-hrc-x172-2-lassosum-mgi-20200608 PRSWEB_PHECODE172.2_UKBB-SAIGE-HRC-X172.2_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE172.2_UKBB-SAIGE-HRC-X172.2_LASSOSUM_MGI_20200608 172.2 Other non-epithelial cancer of skin Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative lassosum UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 7231 2.4e-54 0.0243516 0.136 0.59 0.578-0.601 OR 3.5 2.63-4.65 3.5 2.63-4.65 2.8 2.25-3.48 2.8 2.25-3.48 2.1 1.8-2.45 2.1 1.8-2.45 1.97 1.76-2.22 1.97 1.76-2.22 1.76 1.61-1.93 1.76 1.61-1.93 1.24 1.08-1.41 0.00158 1.56 1.37-1.77 8.1e-12 2.23 1.98-2.52 4.32e-38 True False False True Both 2954 12944 GRCh37/hg19 s=0.2;Lambda=0.01438 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000444/ScoringFiles/ https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000444/ScoringFiles/ /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE172.2_UKBB-SAIGE-HRC-X172.2_LASSOSUM_MGI_20200608/all.tsv /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE172.2_UKBB-SAIGE-HRC-X172.2_LASSOSUM_MGI_20200608/exclusion.tsv 2020-06-08