prs_id slug legacy_id legacy_model prswebprefix trait_code trait_name trait_type description cohort cohort_label method gwas_source reference_label reference_url snp_count p_value pseudo_r2 brier_score mse aauc aauc_ci effect_metric top_effect_1 top_effect_1_ci top_or_1 top_or_1_ci top_effect_2 top_effect_2_ci top_or_2 top_or_2_ci top_effect_5 top_effect_5_ci top_or_5 top_or_5_ci top_effect_10 top_effect_10_ci top_or_10 top_or_10_ci top_effect_25 top_effect_25_ci top_or_25 top_or_25_ci q1_vs_q2_effect q1_vs_q2_effect_ci q1_vs_q2_p_value q1_vs_q3_effect q1_vs_q3_effect_ci q1_vs_q3_p_value q1_vs_q4_effect q1_vs_q4_effect_ci q1_vs_q4_p_value nominally_significant reversed_effect_warning underpowered_warning upload_to_portal sex cases controls genome_build tuning_parameter weights_external_url weights_url phewas_download_url exclusion_download_url last_updated prsweb-phecode174-1-20001-1002-p-5e-05-mgi-20200608 prsweb-phecode174-1-20001-1002-p-5e-05-mgi-20200608 PRSWEB_PHECODE174.1_20001-1002_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE174.1_20001-1002_P_5e-05_MGI_20200608 174.1 Cancer code, self-reported: breast cancer Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 210 1.8e-18 0.0116583 0.138 0.576 0.559-0.593 OR 1.53 0.92-2.55 1.53 0.92-2.55 1.57 1.09-2.26 1.57 1.09-2.26 1.56 1.24-1.98 1.56 1.24-1.98 1.59 1.34-1.89 1.59 1.34-1.89 1.56 1.37-1.77 1.56 1.37-1.77 1.2 0.994-1.45 0.0582 1.61 1.35-1.93 1.75e-07 1.97 1.65-2.34 2.3e-14 True False False False Female 1341 6444 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode174-1-c3-breast-3-p-5e-05-mgi-20200608 prsweb-phecode174-1-c3-breast-3-p-5e-05-mgi-20200608 PRSWEB_PHECODE174.1_C3-BREAST-3_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE174.1_C3-BREAST-3_P_5e-05_MGI_20200608 174.1 Malignant neoplasm of breast Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 233 5.4e-24 0.0118695 0.138 0.586 0.57-0.603 OR 1.82 1.13-2.93 1.82 1.13-2.93 1.78 1.25-2.53 1.78 1.25-2.53 1.73 1.38-2.18 1.73 1.38-2.18 1.89 1.6-2.23 1.89 1.6-2.23 1.69 1.49-1.92 1.69 1.49-1.92 1.45 1.2-1.75 0.000122 1.69 1.4-2.04 3.11e-08 2.33 1.95-2.78 2.46e-20 True False False False Female 1341 6444 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode174-1-c50-p-5e-05-mgi-20200608 prsweb-phecode174-1-c50-p-5e-05-mgi-20200608 PRSWEB_PHECODE174.1_C50_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE174.1_C50_P_5e-05_MGI_20200608 174.1 Diagnoses - main ICD10: C50 Malignant neoplasm of breast Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 197 3e-21 0.00971314 0.138 0.584 0.567-0.601 OR 1.77 1.08-2.9 1.77 1.08-2.9 1.47 1.02-2.13 1.47 1.02-2.13 1.44 1.13-1.83 1.44 1.13-1.83 1.54 1.3-1.84 1.54 1.3-1.84 1.64 1.44-1.86 1.64 1.44-1.86 1.4 1.15-1.7 0.000634 1.82 1.52-2.19 1.91e-10 2.29 1.92-2.74 1.26e-19 True False False False Female 1341 6444 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode174-1-d05-p-5e-05-mgi-20200608 prsweb-phecode174-1-d05-p-5e-05-mgi-20200608 PRSWEB_PHECODE174.1_D05_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE174.1_D05_P_5e-05_MGI_20200608 174.1 Diagnoses - main ICD10: D05 Carcinoma in situ of breast Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 120 0.0055 0.000697087 0.14 0.517 0.499-0.534 OR 1.16 0.667-2.02 1.16 0.667-2.02 1.12 0.742-1.69 1.12 0.742-1.69 1.15 0.887-1.48 1.15 0.887-1.48 1.15 0.948-1.38 1.15 0.948-1.38 1.11 0.965-1.27 1.11 0.965-1.27 1.02 0.855-1.21 0.849 1.19 1-1.41 0.0449 1.18 0.998-1.4 0.0533 True False False False Female 1341 6444 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode174-1-gwas-catalog-r2019-05-03-x174-1-p-5e-05-mgi-20200608 prsweb-phecode174-1-gwas-catalog-r2019-05-03-x174-1-p-5e-05-mgi-20200608 PRSWEB_PHECODE174.1_GWAS-Catalog-r2019-05-03-X174.1_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE174.1_GWAS-Catalog-r2019-05-03-X174.1_P_5e-05_MGI_20200608 174.1 Breast cancer;Breast cancer (estrogen-receptor negative);Breast Cancer in BRCA1 mutation carriers;Breast cancer in BRCA2 mutation carriers Binary 136 unique SNPs MGI Michigan Genomics Initiative Fixed threshold (5e-05) GWAS Catalog (2019-05-03) 17529967;17529973;17529974;18326623;19330027;19330030;20453838;20852631;20872241;21263130;21424380;23354978;23535729;23535733;23544012;23544013;25751625;29058716;29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=17529967+17529973+17529974+18326623+19330027+19330030+20453838+20852631+20872241+21263130+21424380+23354978+23535729+23535733+23544012+23544013+25751625+29058716+29059683 62 5.2e-37 0.0207597 0.136 0.607 0.589-0.623 OR 3.06 2.04-4.6 3.06 2.04-4.6 2.35 1.71-3.24 2.35 1.71-3.24 2.21 1.79-2.74 2.21 1.79-2.74 2.26 1.93-2.65 2.26 1.93-2.65 1.9 1.68-2.16 1.9 1.68-2.16 1.45 1.2-1.77 0.000182 1.75 1.45-2.12 9.46e-09 2.68 2.23-3.21 1.95e-26 True False False False Female 1341 6444 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode174-1-onco-icogs-er-negative-brca-p-5e-05-mgi-20200608 prsweb-phecode174-1-onco-icogs-er-negative-brca-p-5e-05-mgi-20200608 PRSWEB_PHECODE174.1_Onco-iCOGS-ER-negative-BRCA_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE174.1_Onco-iCOGS-ER-negative-BRCA_P_5e-05_MGI_20200608 174.1 Breast cancer [female]; ER negative Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). MGI Michigan Genomics Initiative Fixed threshold (5e-05) Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 392 1.8e-18 0.00931451 0.138 0.575 0.557-0.592 OR 2.15 1.37-3.39 2.15 1.37-3.39 1.82 1.3-2.56 1.82 1.3-2.56 1.79 1.43-2.24 1.79 1.43-2.24 1.67 1.41-1.98 1.67 1.41-1.98 1.56 1.37-1.78 1.56 1.37-1.78 1.27 1.05-1.53 0.0123 1.53 1.28-1.84 3.78e-06 1.98 1.66-2.35 2.38e-14 True False False False Female 1341 6444 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode174-1-onco-icogs-er-positive-brca-p-5e-05-mgi-20200608 prsweb-phecode174-1-onco-icogs-er-positive-brca-p-5e-05-mgi-20200608 PRSWEB_PHECODE174.1_Onco-iCOGS-ER-positive-BRCA_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE174.1_Onco-iCOGS-ER-positive-BRCA_P_5e-05_MGI_20200608 174.1 Breast cancer [female]; ER positive Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). MGI Michigan Genomics Initiative Fixed threshold (5e-05) Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 950 6.5e-43 0.0347636 0.136 0.618 0.602-0.635 OR 2.91 1.93-4.4 2.91 1.93-4.4 2.65 1.96-3.6 2.65 1.96-3.6 2.27 1.84-2.8 2.27 1.84-2.8 2.21 1.88-2.59 2.21 1.88-2.59 2.11 1.87-2.39 2.11 1.87-2.39 1.48 1.21-1.82 0.000126 1.84 1.52-2.24 7.24e-10 3.01 2.51-3.62 4.62e-32 True False False False Female 1341 6444 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode174-1-onco-icogs-overall-brca-p-5e-05-mgi-20200608 prsweb-phecode174-1-onco-icogs-overall-brca-p-5e-05-mgi-20200608 PRSWEB_PHECODE174.1_Onco-iCOGS-Overall-BRCA_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE174.1_Onco-iCOGS-Overall-BRCA_P_5e-05_MGI_20200608 174.1 Breast cancer [female], Overall Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). MGI Michigan Genomics Initiative Fixed threshold (5e-05) Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 1307 1.9e-52 0.0391681 0.135 0.634 0.618-0.65 OR 2.75 1.81-4.17 2.75 1.81-4.17 2.93 2.18-3.94 2.93 2.18-3.94 2.76 2.26-3.37 2.76 2.26-3.37 2.66 2.28-3.11 2.66 2.28-3.11 2.22 1.96-2.52 2.22 1.96-2.52 1.42 1.15-1.75 0.00108 2.15 1.76-2.62 3.21e-14 3.29 2.72-3.96 1.49e-35 True False False False Female 1341 6444 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode174-1-ukbb-saige-hrc-x174-1-p-5e-05-mgi-20200608 prsweb-phecode174-1-ukbb-saige-hrc-x174-1-p-5e-05-mgi-20200608 PRSWEB_PHECODE174.1_UKBB-SAIGE-HRC-X174.1_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE174.1_UKBB-SAIGE-HRC-X174.1_P_5e-05_MGI_20200608 174.1 Breast cancer [female] Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 289 3.2e-29 0.0179676 0.137 0.597 0.581-0.613 OR 1.93 1.21-3.09 1.93 1.21-3.09 2.07 1.49-2.87 2.07 1.49-2.87 1.98 1.6-2.47 1.98 1.6-2.47 1.86 1.57-2.19 1.86 1.57-2.19 1.82 1.6-2.06 1.82 1.6-2.06 1.4 1.15-1.7 0.000741 1.78 1.47-2.15 1.95e-09 2.54 2.12-3.04 2.79e-24 True False False False Female 1341 6444 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode174-1-icogs-er-negative-brca-p-5e-05-mgi-20200608 prsweb-phecode174-1-icogs-er-negative-brca-p-5e-05-mgi-20200608 PRSWEB_PHECODE174.1_iCOGS-ER-negative-BRCA_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE174.1_iCOGS-ER-negative-BRCA_P_5e-05_MGI_20200608 174.1 Breast cancer [female]; ER negative Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). MGI Michigan Genomics Initiative Fixed threshold (5e-05) Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 158 4e-04 0.00222527 0.14 0.53 0.512-0.547 OR 1.53 0.917-2.54 1.53 0.917-2.54 1.28 0.865-1.89 1.28 0.865-1.89 1.23 0.956-1.59 1.23 0.956-1.59 1.24 1.03-1.49 1.24 1.03-1.49 1.27 1.11-1.45 1.27 1.11-1.45 0.984 0.825-1.17 0.853 1.11 0.935-1.32 0.233 1.31 1.11-1.54 0.00156 True False False False Female 1341 6444 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode174-1-icogs-er-positive-brca-p-5e-05-mgi-20200608 prsweb-phecode174-1-icogs-er-positive-brca-p-5e-05-mgi-20200608 PRSWEB_PHECODE174.1_iCOGS-ER-positive-BRCA_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE174.1_iCOGS-ER-positive-BRCA_P_5e-05_MGI_20200608 174.1 Breast cancer [female]; ER positive Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). MGI Michigan Genomics Initiative Fixed threshold (5e-05) Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 423 5.7e-27 0.0216201 0.137 0.592 0.576-0.61 OR 2.41 1.56-3.71 2.41 1.56-3.71 2.4 1.75-3.28 2.4 1.75-3.28 1.96 1.58-2.44 1.96 1.58-2.44 1.79 1.52-2.12 1.79 1.52-2.12 1.82 1.61-2.07 1.82 1.61-2.07 1.27 1.05-1.54 0.012 1.47 1.22-1.77 5.3e-05 2.25 1.9-2.68 3.37e-20 True False False False Female 1341 6444 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode174-1-icogs-overall-brca-p-5e-05-mgi-20200608 prsweb-phecode174-1-icogs-overall-brca-p-5e-05-mgi-20200608 PRSWEB_PHECODE174.1_iCOGS-Overall-BRCA_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE174.1_iCOGS-Overall-BRCA_P_5e-05_MGI_20200608 174.1 Breast cancer [female], Overall Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). MGI Michigan Genomics Initiative Fixed threshold (5e-05) Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 534 8.9e-35 0.0250961 0.137 0.608 0.591-0.625 OR 2.44 1.56-3.81 2.44 1.56-3.81 1.99 1.42-2.8 1.99 1.42-2.8 1.86 1.49-2.32 1.86 1.49-2.32 1.91 1.62-2.25 1.91 1.62-2.25 1.84 1.62-2.08 1.84 1.62-2.08 1.36 1.11-1.66 0.00299 2.1 1.74-2.54 1.47e-14 2.71 2.26-3.26 1.58e-26 True False False False Female 1341 6444 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode174-1-20001-1002-p-5e-06-mgi-20200608 prsweb-phecode174-1-20001-1002-p-5e-06-mgi-20200608 PRSWEB_PHECODE174.1_20001-1002_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE174.1_20001-1002_P_5e-06_MGI_20200608 174.1 Cancer code, self-reported: breast cancer Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 62 2.9e-21 0.0126436 0.138 0.58 0.562-0.597 OR 1.72 1.06-2.79 1.72 1.06-2.79 2.09 1.51-2.9 2.09 1.51-2.9 1.84 1.47-2.3 1.84 1.47-2.3 1.68 1.42-1.99 1.68 1.42-1.99 1.72 1.52-1.95 1.72 1.52-1.95 1.23 1.02-1.48 0.0303 1.43 1.19-1.72 0.000118 2.1 1.77-2.49 3.69e-17 True False False False Female 1341 6444 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode174-1-c3-breast-3-p-5e-06-mgi-20200608 prsweb-phecode174-1-c3-breast-3-p-5e-06-mgi-20200608 PRSWEB_PHECODE174.1_C3-BREAST-3_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE174.1_C3-BREAST-3_P_5e-06_MGI_20200608 174.1 Malignant neoplasm of breast Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 88 5.6e-28 0.0139773 0.137 0.594 0.577-0.611 OR 2.03 1.28-3.23 2.03 1.28-3.23 1.77 1.25-2.52 1.77 1.25-2.52 1.87 1.49-2.33 1.87 1.49-2.33 1.67 1.4-1.98 1.67 1.4-1.98 1.73 1.53-1.97 1.73 1.53-1.97 1.3 1.07-1.58 0.00836 1.74 1.45-2.09 3.42e-09 2.31 1.94-2.76 1.8e-20 True False False False Female 1341 6444 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode174-1-c50-p-5e-06-mgi-20200608 prsweb-phecode174-1-c50-p-5e-06-mgi-20200608 PRSWEB_PHECODE174.1_C50_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE174.1_C50_P_5e-06_MGI_20200608 174.1 Diagnoses - main ICD10: C50 Malignant neoplasm of breast Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 66 4.2e-24 0.0109453 0.138 0.585 0.568-0.601 OR 2.57 1.68-3.95 2.57 1.68-3.95 2 1.43-2.78 2 1.43-2.78 1.66 1.32-2.09 1.66 1.32-2.09 1.82 1.54-2.15 1.82 1.54-2.15 1.63 1.43-1.85 1.63 1.43-1.85 1.37 1.13-1.66 0.00137 1.75 1.46-2.11 2e-09 2.24 1.87-2.68 7.64e-19 True False False False Female 1341 6444 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode174-1-d05-p-5e-06-mgi-20200608 prsweb-phecode174-1-d05-p-5e-06-mgi-20200608 PRSWEB_PHECODE174.1_D05_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE174.1_D05_P_5e-06_MGI_20200608 174.1 Diagnoses - main ICD10: D05 Carcinoma in situ of breast Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 19 0.00016 0.00134743 0.139 0.519 0.502-0.536 OR 1.46 0.87-2.46 1.46 0.87-2.46 1.25 0.843-1.84 1.25 0.843-1.84 1.1 0.849-1.43 1.1 0.849-1.43 1.33 1.11-1.59 1.33 1.11-1.59 1.22 1.07-1.39 1.22 1.07-1.39 1.04 0.868-1.23 0.7 1.2 1.01-1.43 0.0333 1.32 1.11-1.56 0.0013 True False False False Female 1341 6444 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode174-1-gwas-catalog-r2019-05-03-x174-1-p-5e-06-mgi-20200608 prsweb-phecode174-1-gwas-catalog-r2019-05-03-x174-1-p-5e-06-mgi-20200608 PRSWEB_PHECODE174.1_GWAS-Catalog-r2019-05-03-X174.1_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE174.1_GWAS-Catalog-r2019-05-03-X174.1_P_5e-06_MGI_20200608 174.1 Breast cancer;Breast cancer (estrogen-receptor negative);Breast Cancer in BRCA1 mutation carriers;Breast cancer in BRCA2 mutation carriers Binary 136 unique SNPs MGI Michigan Genomics Initiative Fixed threshold (5e-06) GWAS Catalog (2019-05-03) 17529967;17529973;17529974;18326623;19330027;19330030;20453838;20852631;20872241;21263130;21424380;23354978;23535729;23535733;23544012;23544013;25751625;29058716;29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=17529967+17529973+17529974+18326623+19330027+19330030+20453838+20852631+20872241+21263130+21424380+23354978+23535729+23535733+23544012+23544013+25751625+29058716+29059683 62 5.2e-37 0.0207597 0.136 0.607 0.589-0.623 OR 3.06 2.04-4.6 3.06 2.04-4.6 2.35 1.71-3.24 2.35 1.71-3.24 2.21 1.79-2.74 2.21 1.79-2.74 2.26 1.93-2.65 2.26 1.93-2.65 1.9 1.68-2.16 1.9 1.68-2.16 1.45 1.2-1.77 0.000182 1.75 1.45-2.12 9.46e-09 2.68 2.23-3.21 1.95e-26 True False False False Female 1341 6444 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode174-1-onco-icogs-er-negative-brca-p-5e-06-mgi-20200608 prsweb-phecode174-1-onco-icogs-er-negative-brca-p-5e-06-mgi-20200608 PRSWEB_PHECODE174.1_Onco-iCOGS-ER-negative-BRCA_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE174.1_Onco-iCOGS-ER-negative-BRCA_P_5e-06_MGI_20200608 174.1 Breast cancer [female]; ER negative Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). MGI Michigan Genomics Initiative Fixed threshold (5e-06) Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 133 1.6e-16 0.00841717 0.138 0.569 0.552-0.587 OR 2.05 1.3-3.23 2.05 1.3-3.23 1.82 1.3-2.57 1.82 1.3-2.57 1.71 1.36-2.14 1.71 1.36-2.14 1.63 1.38-1.94 1.63 1.38-1.94 1.55 1.37-1.76 1.55 1.37-1.76 1.27 1.06-1.53 0.0109 1.43 1.19-1.72 0.00011 1.89 1.59-2.24 8.47e-13 True False False False Female 1341 6444 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode174-1-onco-icogs-er-positive-brca-p-5e-06-mgi-20200608 prsweb-phecode174-1-onco-icogs-er-positive-brca-p-5e-06-mgi-20200608 PRSWEB_PHECODE174.1_Onco-iCOGS-ER-positive-BRCA_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE174.1_Onco-iCOGS-ER-positive-BRCA_P_5e-06_MGI_20200608 174.1 Breast cancer [female]; ER positive Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). MGI Michigan Genomics Initiative Fixed threshold (5e-06) Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 495 2e-39 0.032 0.136 0.613 0.596-0.629 OR 2.29 1.47-3.56 2.29 1.47-3.56 2.2 1.59-3.04 2.2 1.59-3.04 2.35 1.9-2.89 2.35 1.9-2.89 2.05 1.74-2.41 2.05 1.74-2.41 1.89 1.67-2.15 1.89 1.67-2.15 1.4 1.14-1.7 0.00108 1.94 1.61-2.35 7.03e-12 2.71 2.26-3.25 6.27e-27 True False False False Female 1341 6444 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode174-1-onco-icogs-overall-brca-p-5e-06-mgi-20200608 prsweb-phecode174-1-onco-icogs-overall-brca-p-5e-06-mgi-20200608 PRSWEB_PHECODE174.1_Onco-iCOGS-Overall-BRCA_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE174.1_Onco-iCOGS-Overall-BRCA_P_5e-06_MGI_20200608 174.1 Breast cancer [female], Overall Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). MGI Michigan Genomics Initiative Fixed threshold (5e-06) Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 712 3.8e-49 0.0387775 0.135 0.629 0.612-0.645 OR 3.06 2.04-4.59 3.06 2.04-4.59 3.39 2.55-4.5 3.39 2.55-4.5 2.57 2.09-3.15 2.57 2.09-3.15 2.24 1.91-2.63 2.24 1.91-2.63 2.07 1.83-2.35 2.07 1.83-2.35 1.43 1.16-1.77 0.000711 2.23 1.84-2.71 5.14e-16 3.19 2.64-3.85 8.07e-34 True False False False Female 1341 6444 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode174-1-ukbb-saige-hrc-x174-1-p-5e-06-mgi-20200608 prsweb-phecode174-1-ukbb-saige-hrc-x174-1-p-5e-06-mgi-20200608 PRSWEB_PHECODE174.1_UKBB-SAIGE-HRC-X174.1_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE174.1_UKBB-SAIGE-HRC-X174.1_P_5e-06_MGI_20200608 174.1 Breast cancer [female] Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 109 3.3e-34 0.0169766 0.137 0.605 0.588-0.622 OR 2.21 1.41-3.45 2.21 1.41-3.45 2.63 1.94-3.57 2.63 1.94-3.57 1.97 1.58-2.45 1.97 1.58-2.45 1.79 1.51-2.12 1.79 1.51-2.12 1.98 1.74-2.24 1.98 1.74-2.24 1.51 1.24-1.83 4.47e-05 1.76 1.45-2.13 1.02e-08 2.79 2.33-3.35 1.09e-28 True False False False Female 1341 6444 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode174-1-icogs-er-negative-brca-p-5e-06-mgi-20200608 prsweb-phecode174-1-icogs-er-negative-brca-p-5e-06-mgi-20200608 PRSWEB_PHECODE174.1_iCOGS-ER-negative-BRCA_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE174.1_iCOGS-ER-negative-BRCA_P_5e-06_MGI_20200608 174.1 Breast cancer [female]; ER negative Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). MGI Michigan Genomics Initiative Fixed threshold (5e-06) Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 35 1.8e-09 0.00404105 0.139 0.546 0.528-0.561 OR 1.99 1.25-3.18 1.99 1.25-3.18 1.81 1.28-2.55 1.81 1.28-2.55 1.48 1.16-1.87 1.48 1.16-1.87 1.37 1.14-1.64 1.37 1.14-1.64 1.32 1.16-1.5 1.32 1.16-1.5 1.14 0.95-1.37 0.16 1.41 1.18-1.68 0.000111 1.55 1.31-1.84 5.36e-07 True False False False Female 1341 6444 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode174-1-icogs-er-positive-brca-p-5e-06-mgi-20200608 prsweb-phecode174-1-icogs-er-positive-brca-p-5e-06-mgi-20200608 PRSWEB_PHECODE174.1_iCOGS-ER-positive-BRCA_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE174.1_iCOGS-ER-positive-BRCA_P_5e-06_MGI_20200608 174.1 Breast cancer [female]; ER positive Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). MGI Michigan Genomics Initiative Fixed threshold (5e-06) Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 185 3.2e-33 0.0227923 0.137 0.601 0.584-0.617 OR 2.94 1.95-4.44 2.94 1.95-4.44 2.42 1.77-3.32 2.42 1.77-3.32 1.96 1.57-2.44 1.96 1.57-2.44 1.9 1.61-2.24 1.9 1.61-2.24 1.83 1.61-2.08 1.83 1.61-2.08 1.37 1.13-1.67 0.00168 1.85 1.54-2.24 1.18e-10 2.54 2.13-3.04 2.06e-24 True False False False Female 1341 6444 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode174-1-icogs-overall-brca-p-5e-06-mgi-20200608 prsweb-phecode174-1-icogs-overall-brca-p-5e-06-mgi-20200608 PRSWEB_PHECODE174.1_iCOGS-Overall-BRCA_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE174.1_iCOGS-Overall-BRCA_P_5e-06_MGI_20200608 174.1 Breast cancer [female], Overall Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). MGI Michigan Genomics Initiative Fixed threshold (5e-06) Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 246 1.2e-40 0.0251426 0.136 0.613 0.597-0.631 OR 2.8 1.85-4.25 2.8 1.85-4.25 2.23 1.62-3.08 2.23 1.62-3.08 2.07 1.67-2.57 2.07 1.67-2.57 2.11 1.79-2.48 2.11 1.79-2.48 2.03 1.79-2.3 2.03 1.79-2.3 1.46 1.2-1.79 0.00021 1.92 1.58-2.33 3.57e-11 2.96 2.47-3.56 3.62e-31 True False False False Female 1341 6444 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode174-1-20001-1002-p-5e-07-mgi-20200608 prsweb-phecode174-1-20001-1002-p-5e-07-mgi-20200608 PRSWEB_PHECODE174.1_20001-1002_P_5e-07_MGI_20200608 P_5e-07 PRSWEB_PHECODE174.1_20001-1002_P_5e-07_MGI_20200608 174.1 Cancer code, self-reported: breast cancer Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-07) UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 33 1.2e-22 0.00955433 0.138 0.581 0.564-0.598 OR 2.17 1.38-3.42 2.17 1.38-3.42 2.32 1.69-3.18 2.32 1.69-3.18 1.91 1.53-2.38 1.91 1.53-2.38 1.59 1.34-1.89 1.59 1.34-1.89 1.61 1.42-1.83 1.61 1.42-1.83 1.24 1.02-1.5 0.0271 1.71 1.43-2.05 5.82e-09 2.12 1.78-2.53 6.17e-17 True False False False Female 1341 6444 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode174-1-c3-breast-3-p-5e-07-mgi-20200608 prsweb-phecode174-1-c3-breast-3-p-5e-07-mgi-20200608 PRSWEB_PHECODE174.1_C3-BREAST-3_P_5e-07_MGI_20200608 P_5e-07 PRSWEB_PHECODE174.1_C3-BREAST-3_P_5e-07_MGI_20200608 174.1 Malignant neoplasm of breast Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-07) UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 45 1.3e-23 0.0100018 0.138 0.585 0.568-0.602 OR 2.22 1.43-3.46 2.22 1.43-3.46 1.86 1.32-2.6 1.86 1.32-2.6 1.89 1.52-2.37 1.89 1.52-2.37 1.63 1.37-1.94 1.63 1.37-1.94 1.64 1.44-1.86 1.64 1.44-1.86 1.29 1.07-1.57 0.00892 1.75 1.46-2.1 1.46e-09 2.21 1.85-2.63 1.56e-18 True False False False Female 1341 6444 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode174-1-c50-p-5e-07-mgi-20200608 prsweb-phecode174-1-c50-p-5e-07-mgi-20200608 PRSWEB_PHECODE174.1_C50_P_5e-07_MGI_20200608 P_5e-07 PRSWEB_PHECODE174.1_C50_P_5e-07_MGI_20200608 174.1 Diagnoses - main ICD10: C50 Malignant neoplasm of breast Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-07) UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 29 4.2e-23 0.010297 0.138 0.582 0.565-0.599 OR 1.85 1.16-2.96 1.85 1.16-2.96 1.9 1.36-2.67 1.9 1.36-2.67 1.66 1.32-2.09 1.66 1.32-2.09 1.64 1.38-1.95 1.64 1.38-1.95 1.66 1.47-1.89 1.66 1.47-1.89 1.49 1.23-1.8 5.13e-05 1.74 1.44-2.09 6.84e-09 2.33 1.94-2.78 2.63e-20 True False False False Female 1341 6444 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode174-1-gwas-catalog-r2019-05-03-x174-1-p-5e-07-mgi-20200608 prsweb-phecode174-1-gwas-catalog-r2019-05-03-x174-1-p-5e-07-mgi-20200608 PRSWEB_PHECODE174.1_GWAS-Catalog-r2019-05-03-X174.1_P_5e-07_MGI_20200608 P_5e-07 PRSWEB_PHECODE174.1_GWAS-Catalog-r2019-05-03-X174.1_P_5e-07_MGI_20200608 174.1 Breast cancer;Breast cancer (estrogen-receptor negative);Breast Cancer in BRCA1 mutation carriers;Breast cancer in BRCA2 mutation carriers Binary 136 unique SNPs MGI Michigan Genomics Initiative Fixed threshold (5e-07) GWAS Catalog (2019-05-03) 17529967;17529973;17529974;18326623;19330027;19330030;20453838;20852631;20872241;21263130;21424380;23354978;23535729;23535733;23544012;23544013;25751625;29058716;29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=17529967+17529973+17529974+18326623+19330027+19330030+20453838+20852631+20872241+21263130+21424380+23354978+23535729+23535733+23544012+23544013+25751625+29058716+29059683 62 5.2e-37 0.0207597 0.136 0.607 0.589-0.623 OR 3.06 2.04-4.6 3.06 2.04-4.6 2.35 1.71-3.24 2.35 1.71-3.24 2.21 1.79-2.74 2.21 1.79-2.74 2.26 1.93-2.65 2.26 1.93-2.65 1.9 1.68-2.16 1.9 1.68-2.16 1.45 1.2-1.77 0.000182 1.75 1.45-2.12 9.46e-09 2.68 2.23-3.21 1.95e-26 True False False False Female 1341 6444 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode174-1-onco-icogs-er-negative-brca-p-5e-07-mgi-20200608 prsweb-phecode174-1-onco-icogs-er-negative-brca-p-5e-07-mgi-20200608 PRSWEB_PHECODE174.1_Onco-iCOGS-ER-negative-BRCA_P_5e-07_MGI_20200608 P_5e-07 PRSWEB_PHECODE174.1_Onco-iCOGS-ER-negative-BRCA_P_5e-07_MGI_20200608 174.1 Breast cancer [female]; ER negative Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). MGI Michigan Genomics Initiative Fixed threshold (5e-07) Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 73 6.2e-12 0.0083856 0.139 0.557 0.54-0.574 OR 1.62 0.98-2.67 1.62 0.98-2.67 1.87 1.33-2.62 1.87 1.33-2.62 1.54 1.21-1.95 1.54 1.21-1.95 1.4 1.17-1.68 1.4 1.17-1.68 1.42 1.25-1.62 1.42 1.25-1.62 1.39 1.16-1.67 0.000418 1.53 1.28-1.84 4.1e-06 1.85 1.55-2.21 7.89e-12 True False False False Female 1341 6444 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode174-1-onco-icogs-er-positive-brca-p-5e-07-mgi-20200608 prsweb-phecode174-1-onco-icogs-er-positive-brca-p-5e-07-mgi-20200608 PRSWEB_PHECODE174.1_Onco-iCOGS-ER-positive-BRCA_P_5e-07_MGI_20200608 P_5e-07 PRSWEB_PHECODE174.1_Onco-iCOGS-ER-positive-BRCA_P_5e-07_MGI_20200608 174.1 Breast cancer [female]; ER positive Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). MGI Michigan Genomics Initiative Fixed threshold (5e-07) Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 343 3.9e-39 0.0302005 0.136 0.612 0.596-0.628 OR 2.47 1.6-3.81 2.47 1.6-3.81 2.28 1.66-3.15 2.28 1.66-3.15 2.18 1.76-2.7 2.18 1.76-2.7 2.2 1.88-2.59 2.2 1.88-2.59 1.88 1.66-2.13 1.88 1.66-2.13 1.23 1.01-1.5 0.0434 1.97 1.64-2.38 1.21e-12 2.6 2.17-3.11 2.13e-25 True False False False Female 1341 6444 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode174-1-onco-icogs-overall-brca-p-5e-07-mgi-20200608 prsweb-phecode174-1-onco-icogs-overall-brca-p-5e-07-mgi-20200608 PRSWEB_PHECODE174.1_Onco-iCOGS-Overall-BRCA_P_5e-07_MGI_20200608 P_5e-07 PRSWEB_PHECODE174.1_Onco-iCOGS-Overall-BRCA_P_5e-07_MGI_20200608 174.1 Breast cancer [female], Overall Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). MGI Michigan Genomics Initiative Fixed threshold (5e-07) Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 464 8e-49 0.0384567 0.135 0.627 0.611-0.644 OR 3.38 2.28-5.02 3.38 2.28-5.02 3.08 2.3-4.14 3.08 2.3-4.14 2.6 2.12-3.19 2.6 2.12-3.19 2.16 1.84-2.54 2.16 1.84-2.54 1.98 1.74-2.24 1.98 1.74-2.24 1.49 1.21-1.84 0.000165 2.37 1.95-2.88 6.45e-18 3.15 2.6-3.81 2.35e-32 True False False False Female 1341 6444 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode174-1-ukbb-saige-hrc-x174-1-p-5e-07-mgi-20200608 prsweb-phecode174-1-ukbb-saige-hrc-x174-1-p-5e-07-mgi-20200608 PRSWEB_PHECODE174.1_UKBB-SAIGE-HRC-X174.1_P_5e-07_MGI_20200608 P_5e-07 PRSWEB_PHECODE174.1_UKBB-SAIGE-HRC-X174.1_P_5e-07_MGI_20200608 174.1 Breast cancer [female] Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative Fixed threshold (5e-07) UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 64 1e-30 0.016038 0.137 0.6 0.584-0.617 OR 2.47 1.59-3.83 2.47 1.59-3.83 1.92 1.37-2.69 1.92 1.37-2.69 1.79 1.43-2.25 1.79 1.43-2.25 1.71 1.45-2.03 1.71 1.45-2.03 1.78 1.57-2.02 1.78 1.57-2.02 1.48 1.22-1.8 9.8e-05 1.94 1.61-2.35 6.24e-12 2.62 2.18-3.14 3.58e-25 True False False False Female 1341 6444 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode174-1-icogs-er-negative-brca-p-5e-07-mgi-20200608 prsweb-phecode174-1-icogs-er-negative-brca-p-5e-07-mgi-20200608 PRSWEB_PHECODE174.1_iCOGS-ER-negative-BRCA_P_5e-07_MGI_20200608 P_5e-07 PRSWEB_PHECODE174.1_iCOGS-ER-negative-BRCA_P_5e-07_MGI_20200608 174.1 Breast cancer [female]; ER negative Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). MGI Michigan Genomics Initiative Fixed threshold (5e-07) Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 14 2.1e-13 0.00713904 0.139 0.556 0.538-0.571 OR 1.69 1.03-2.76 1.69 1.03-2.76 1.87 1.33-2.64 1.87 1.33-2.64 1.54 1.22-1.95 1.54 1.22-1.95 1.51 1.27-1.8 1.51 1.27-1.8 1.49 1.31-1.7 1.49 1.31-1.7 1.32 1.1-1.58 0.00253 1.28 1.07-1.54 0.0072 1.8 1.51-2.13 2.88e-11 True False False False Female 1341 6444 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode174-1-icogs-er-positive-brca-p-5e-07-mgi-20200608 prsweb-phecode174-1-icogs-er-positive-brca-p-5e-07-mgi-20200608 PRSWEB_PHECODE174.1_iCOGS-ER-positive-BRCA_P_5e-07_MGI_20200608 P_5e-07 PRSWEB_PHECODE174.1_iCOGS-ER-positive-BRCA_P_5e-07_MGI_20200608 174.1 Breast cancer [female]; ER positive Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). MGI Michigan Genomics Initiative Fixed threshold (5e-07) Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 113 6.1e-32 0.020021 0.137 0.599 0.583-0.615 OR 2.49 1.61-3.85 2.49 1.61-3.85 2.2 1.59-3.05 2.2 1.59-3.05 2.06 1.66-2.56 2.06 1.66-2.56 1.87 1.58-2.21 1.87 1.58-2.21 1.71 1.51-1.94 1.71 1.51-1.94 1.39 1.14-1.69 0.000926 1.93 1.6-2.33 4.51e-12 2.45 2.04-2.93 2.85e-22 True False False False Female 1341 6444 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode174-1-icogs-overall-brca-p-5e-07-mgi-20200608 prsweb-phecode174-1-icogs-overall-brca-p-5e-07-mgi-20200608 PRSWEB_PHECODE174.1_iCOGS-Overall-BRCA_P_5e-07_MGI_20200608 P_5e-07 PRSWEB_PHECODE174.1_iCOGS-Overall-BRCA_P_5e-07_MGI_20200608 174.1 Breast cancer [female], Overall Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). MGI Michigan Genomics Initiative Fixed threshold (5e-07) Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 154 1.4e-40 0.0216537 0.136 0.614 0.598-0.63 OR 2.28 1.46-3.54 2.28 1.46-3.54 2.26 1.63-3.11 2.26 1.63-3.11 2.16 1.74-2.67 2.16 1.74-2.67 2 1.7-2.35 2 1.7-2.35 1.97 1.74-2.23 1.97 1.74-2.23 1.5 1.23-1.84 8.7e-05 2.05 1.69-2.49 3.34e-13 2.96 2.46-3.56 1.21e-30 True False False False Female 1341 6444 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode174-1-20001-1002-p-5e-09-mgi-20200608 prsweb-phecode174-1-20001-1002-p-5e-09-mgi-20200608 PRSWEB_PHECODE174.1_20001-1002_P_5e-09_MGI_20200608 P_5e-09 PRSWEB_PHECODE174.1_20001-1002_P_5e-09_MGI_20200608 174.1 Cancer code, self-reported: breast cancer Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-09) UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 18 1.1e-21 0.00807385 0.138 0.58 0.563-0.597 OR 1.86 1.15-2.99 1.86 1.15-2.99 1.83 1.3-2.57 1.83 1.3-2.57 1.7 1.35-2.13 1.7 1.35-2.13 1.59 1.33-1.88 1.59 1.33-1.88 1.64 1.45-1.86 1.64 1.45-1.86 1.38 1.15-1.67 0.000729 1.62 1.34-1.94 3.77e-07 2.17 1.82-2.59 5.37e-18 True False False False Female 1341 6444 GRCh37/hg19 P<=5e-09 2020-06-08 prsweb-phecode174-1-c3-breast-3-p-5e-09-mgi-20200608 prsweb-phecode174-1-c3-breast-3-p-5e-09-mgi-20200608 PRSWEB_PHECODE174.1_C3-BREAST-3_P_5e-09_MGI_20200608 P_5e-09 PRSWEB_PHECODE174.1_C3-BREAST-3_P_5e-09_MGI_20200608 174.1 Malignant neoplasm of breast Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-09) UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 21 3.3e-20 0.00760682 0.138 0.575 0.558-0.592 OR 2.38 1.54-3.69 2.38 1.54-3.69 2.5 1.83-3.42 2.5 1.83-3.42 1.7 1.35-2.14 1.7 1.35-2.14 1.56 1.31-1.86 1.56 1.31-1.86 1.57 1.38-1.78 1.57 1.38-1.78 1.39 1.15-1.68 0.000642 1.69 1.4-2.03 2.36e-08 2.12 1.78-2.53 8.49e-17 True False False False Female 1341 6444 GRCh37/hg19 P<=5e-09 2020-06-08 prsweb-phecode174-1-c50-p-5e-09-mgi-20200608 prsweb-phecode174-1-c50-p-5e-09-mgi-20200608 PRSWEB_PHECODE174.1_C50_P_5e-09_MGI_20200608 P_5e-09 PRSWEB_PHECODE174.1_C50_P_5e-09_MGI_20200608 174.1 Diagnoses - main ICD10: C50 Malignant neoplasm of breast Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-09) UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 14 1.9e-17 0.00711794 0.138 0.568 0.551-0.585 OR 1.98 1.25-3.13 1.98 1.25-3.13 1.83 1.3-2.58 1.83 1.3-2.58 1.65 1.31-2.08 1.65 1.31-2.08 1.55 1.3-1.84 1.55 1.3-1.84 1.49 1.31-1.69 1.49 1.31-1.69 1.28 1.06-1.55 0.00933 1.66 1.39-1.99 2.84e-08 1.94 1.63-2.32 1.18e-13 True False False False Female 1341 6444 GRCh37/hg19 P<=5e-09 2020-06-08 prsweb-phecode174-1-gwas-catalog-r2019-05-03-x174-1-p-5e-09-mgi-20200608 prsweb-phecode174-1-gwas-catalog-r2019-05-03-x174-1-p-5e-09-mgi-20200608 PRSWEB_PHECODE174.1_GWAS-Catalog-r2019-05-03-X174.1_P_5e-09_MGI_20200608 P_5e-09 PRSWEB_PHECODE174.1_GWAS-Catalog-r2019-05-03-X174.1_P_5e-09_MGI_20200608 174.1 Breast cancer;Breast cancer (estrogen-receptor negative);Breast Cancer in BRCA1 mutation carriers;Breast cancer in BRCA2 mutation carriers Binary 136 unique SNPs MGI Michigan Genomics Initiative Fixed threshold (5e-09) GWAS Catalog (2019-05-03) 17529967;17529973;17529974;18326623;19330027;19330030;20453838;20852631;20872241;21263130;21424380;23354978;23535729;23535733;23544012;23544013;25751625;29058716;29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=17529967+17529973+17529974+18326623+19330027+19330030+20453838+20852631+20872241+21263130+21424380+23354978+23535729+23535733+23544012+23544013+25751625+29058716+29059683 62 5.2e-37 0.0207597 0.136 0.607 0.589-0.623 OR 3.06 2.04-4.6 3.06 2.04-4.6 2.35 1.71-3.24 2.35 1.71-3.24 2.21 1.79-2.74 2.21 1.79-2.74 2.26 1.93-2.65 2.26 1.93-2.65 1.9 1.68-2.16 1.9 1.68-2.16 1.45 1.2-1.77 0.000182 1.75 1.45-2.12 9.46e-09 2.68 2.23-3.21 1.95e-26 True False False False Female 1341 6444 GRCh37/hg19 P<=5e-09 2020-06-08 prsweb-phecode174-1-onco-icogs-er-negative-brca-p-5e-09-mgi-20200608 prsweb-phecode174-1-onco-icogs-er-negative-brca-p-5e-09-mgi-20200608 PRSWEB_PHECODE174.1_Onco-iCOGS-ER-negative-BRCA_P_5e-09_MGI_20200608 P_5e-09 PRSWEB_PHECODE174.1_Onco-iCOGS-ER-negative-BRCA_P_5e-09_MGI_20200608 174.1 Breast cancer [female]; ER negative Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). MGI Michigan Genomics Initiative Fixed threshold (5e-09) Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 31 2.8e-13 0.00812061 0.139 0.561 0.544-0.578 OR 1.62 0.984-2.68 1.62 0.984-2.68 1.72 1.21-2.44 1.72 1.21-2.44 1.59 1.26-2.01 1.59 1.26-2.01 1.56 1.31-1.86 1.56 1.31-1.86 1.5 1.32-1.7 1.5 1.32-1.7 1.17 0.974-1.41 0.093 1.42 1.19-1.7 0.00011 1.8 1.51-2.13 2.36e-11 True False False False Female 1341 6444 GRCh37/hg19 P<=5e-09 2020-06-08 prsweb-phecode174-1-onco-icogs-er-positive-brca-p-5e-09-mgi-20200608 prsweb-phecode174-1-onco-icogs-er-positive-brca-p-5e-09-mgi-20200608 PRSWEB_PHECODE174.1_Onco-iCOGS-ER-positive-BRCA_P_5e-09_MGI_20200608 P_5e-09 PRSWEB_PHECODE174.1_Onco-iCOGS-ER-positive-BRCA_P_5e-09_MGI_20200608 174.1 Breast cancer [female]; ER positive Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). MGI Michigan Genomics Initiative Fixed threshold (5e-09) Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 210 2.6e-39 0.0267071 0.136 0.612 0.596-0.628 OR 2.82 1.86-4.27 2.82 1.86-4.27 2.15 1.55-2.99 2.15 1.55-2.99 2.5 2.03-3.07 2.5 2.03-3.07 2.1 1.78-2.47 2.1 1.78-2.47 1.88 1.66-2.13 1.88 1.66-2.13 1.38 1.13-1.69 0.00153 2.02 1.67-2.44 5.19e-13 2.74 2.28-3.29 2.61e-27 True False False False Female 1341 6444 GRCh37/hg19 P<=5e-09 2020-06-08 prsweb-phecode174-1-onco-icogs-overall-brca-p-5e-09-mgi-20200608 prsweb-phecode174-1-onco-icogs-overall-brca-p-5e-09-mgi-20200608 PRSWEB_PHECODE174.1_Onco-iCOGS-Overall-BRCA_P_5e-09_MGI_20200608 P_5e-09 PRSWEB_PHECODE174.1_Onco-iCOGS-Overall-BRCA_P_5e-09_MGI_20200608 174.1 Breast cancer [female], Overall Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). MGI Michigan Genomics Initiative Fixed threshold (5e-09) Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 264 1.7e-46 0.0357747 0.136 0.624 0.608-0.64 OR 2.56 1.68-3.9 2.56 1.68-3.9 2.92 2.17-3.93 2.92 2.17-3.93 2.39 1.95-2.95 2.39 1.95-2.95 2.19 1.86-2.57 2.19 1.86-2.57 2.01 1.78-2.28 2.01 1.78-2.28 1.76 1.43-2.17 1.02e-07 2.31 1.89-2.82 2.5e-16 3.37 2.78-4.08 4.68e-35 True False False False Female 1341 6444 GRCh37/hg19 P<=5e-09 2020-06-08 prsweb-phecode174-1-ukbb-saige-hrc-x174-1-p-5e-09-mgi-20200608 prsweb-phecode174-1-ukbb-saige-hrc-x174-1-p-5e-09-mgi-20200608 PRSWEB_PHECODE174.1_UKBB-SAIGE-HRC-X174.1_P_5e-09_MGI_20200608 P_5e-09 PRSWEB_PHECODE174.1_UKBB-SAIGE-HRC-X174.1_P_5e-09_MGI_20200608 174.1 Breast cancer [female] Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative Fixed threshold (5e-09) UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 24 4e-23 0.0091182 0.138 0.583 0.566-0.601 OR 2.37 1.53-3.67 2.37 1.53-3.67 1.9 1.36-2.67 1.9 1.36-2.67 1.69 1.34-2.13 1.69 1.34-2.13 1.61 1.35-1.91 1.61 1.35-1.91 1.67 1.47-1.9 1.67 1.47-1.9 1.42 1.17-1.73 0.000375 1.83 1.52-2.21 1.62e-10 2.37 1.98-2.84 5.44e-21 True False False False Female 1341 6444 GRCh37/hg19 P<=5e-09 2020-06-08 prsweb-phecode174-1-icogs-er-negative-brca-p-5e-09-mgi-20200608 prsweb-phecode174-1-icogs-er-negative-brca-p-5e-09-mgi-20200608 PRSWEB_PHECODE174.1_iCOGS-ER-negative-BRCA_P_5e-09_MGI_20200608 P_5e-09 PRSWEB_PHECODE174.1_iCOGS-ER-negative-BRCA_P_5e-09_MGI_20200608 174.1 Breast cancer [female]; ER negative Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). MGI Michigan Genomics Initiative Fixed threshold (5e-09) Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 8 8.4e-10 0.0055352 0.139 0.543 0.525-0.56 OR 1.74 1.08-2.81 1.74 1.08-2.81 1.66 1.17-2.36 1.66 1.17-2.36 1.5 1.18-1.9 1.5 1.18-1.9 1.51 1.27-1.8 1.51 1.27-1.8 1.34 1.18-1.53 1.34 1.18-1.53 1.37 1.14-1.63 0.000628 1.34 1.11-1.6 0.00171 1.66 1.39-1.97 1.1e-08 True False False False Female 1341 6444 GRCh37/hg19 P<=5e-09 2020-06-08 prsweb-phecode174-1-icogs-er-positive-brca-p-5e-09-mgi-20200608 prsweb-phecode174-1-icogs-er-positive-brca-p-5e-09-mgi-20200608 PRSWEB_PHECODE174.1_iCOGS-ER-positive-BRCA_P_5e-09_MGI_20200608 P_5e-09 PRSWEB_PHECODE174.1_iCOGS-ER-positive-BRCA_P_5e-09_MGI_20200608 174.1 Breast cancer [female]; ER positive Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). MGI Michigan Genomics Initiative Fixed threshold (5e-09) Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 63 2.4e-28 0.0168878 0.137 0.593 0.576-0.61 OR 2.13 1.36-3.34 2.13 1.36-3.34 1.93 1.38-2.7 1.93 1.38-2.7 2.04 1.64-2.54 2.04 1.64-2.54 1.87 1.58-2.21 1.87 1.58-2.21 1.78 1.57-2.01 1.78 1.57-2.01 1.44 1.19-1.75 0.000215 1.75 1.45-2.12 4.91e-09 2.47 2.06-2.96 4.78e-23 True False False False Female 1341 6444 GRCh37/hg19 P<=5e-09 2020-06-08 prsweb-phecode174-1-icogs-overall-brca-p-5e-09-mgi-20200608 prsweb-phecode174-1-icogs-overall-brca-p-5e-09-mgi-20200608 PRSWEB_PHECODE174.1_iCOGS-Overall-BRCA_P_5e-09_MGI_20200608 P_5e-09 PRSWEB_PHECODE174.1_iCOGS-Overall-BRCA_P_5e-09_MGI_20200608 174.1 Breast cancer [female], Overall Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). MGI Michigan Genomics Initiative Fixed threshold (5e-09) Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 77 1.4e-34 0.0211168 0.137 0.603 0.587-0.62 OR 2.33 1.51-3.6 2.33 1.51-3.6 2.26 1.64-3.11 2.26 1.64-3.11 2.2 1.78-2.72 2.2 1.78-2.72 1.87 1.58-2.2 1.87 1.58-2.2 1.79 1.58-2.03 1.79 1.58-2.03 1.6 1.31-1.96 4.25e-06 2.12 1.75-2.57 2.27e-14 2.78 2.31-3.35 3.68e-27 True False False False Female 1341 6444 GRCh37/hg19 P<=5e-09 2020-06-08 prsweb-phecode174-1-20001-1002-p-5e-08-mgi-20200608 prsweb-phecode174-1-20001-1002-p-5e-08-mgi-20200608 PRSWEB_PHECODE174.1_20001-1002_P_5e-08_MGI_20200608 P_5e-08 PRSWEB_PHECODE174.1_20001-1002_P_5e-08_MGI_20200608 174.1 Cancer code, self-reported: breast cancer Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative GWAS Hits UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 22 2.3e-22 0.00810679 0.138 0.579 0.561-0.597 OR 2.32 1.49-3.61 2.32 1.49-3.61 2.23 1.62-3.08 2.23 1.62-3.08 1.87 1.5-2.34 1.87 1.5-2.34 1.81 1.53-2.14 1.81 1.53-2.14 1.66 1.46-1.89 1.66 1.46-1.89 1.29 1.07-1.56 0.00877 1.59 1.32-1.91 6.65e-07 2.14 1.8-2.55 1.32e-17 True False False True Female 1341 6444 GRCh37/hg19 P<=5e-08 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000472/ScoringFiles/ https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000472/ScoringFiles/ /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE174.1_20001-1002_P_5e-08_MGI_20200608/all.tsv /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE174.1_20001-1002_P_5e-08_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode174-1-c3-breast-3-p-5e-08-mgi-20200608 prsweb-phecode174-1-c3-breast-3-p-5e-08-mgi-20200608 PRSWEB_PHECODE174.1_C3-BREAST-3_P_5e-08_MGI_20200608 P_5e-08 PRSWEB_PHECODE174.1_C3-BREAST-3_P_5e-08_MGI_20200608 174.1 Malignant neoplasm of breast Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative GWAS Hits UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 32 2e-24 0.0103629 0.138 0.585 0.569-0.603 OR 1.97 1.24-3.14 1.97 1.24-3.14 2.19 1.59-3.02 2.19 1.59-3.02 1.75 1.39-2.19 1.75 1.39-2.19 1.55 1.3-1.85 1.55 1.3-1.85 1.62 1.42-1.84 1.62 1.42-1.84 1.4 1.15-1.69 0.000681 1.81 1.51-2.18 2.66e-10 2.24 1.88-2.68 5.94e-19 True False False True Female 1341 6444 GRCh37/hg19 P<=5e-08 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000476/ScoringFiles/ https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000476/ScoringFiles/ /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE174.1_C3-BREAST-3_P_5e-08_MGI_20200608/all.tsv /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE174.1_C3-BREAST-3_P_5e-08_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode174-1-c50-p-5e-08-mgi-20200608 prsweb-phecode174-1-c50-p-5e-08-mgi-20200608 PRSWEB_PHECODE174.1_C50_P_5e-08_MGI_20200608 P_5e-08 PRSWEB_PHECODE174.1_C50_P_5e-08_MGI_20200608 174.1 Diagnoses - main ICD10: C50 Malignant neoplasm of breast Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative GWAS Hits UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 20 6.4e-21 0.00827899 0.138 0.576 0.559-0.593 OR 1.91 1.2-3.03 1.91 1.2-3.03 1.97 1.41-2.76 1.97 1.41-2.76 1.68 1.33-2.11 1.68 1.33-2.11 1.6 1.34-1.9 1.6 1.34-1.9 1.57 1.38-1.78 1.57 1.38-1.78 1.56 1.29-1.89 3.9e-06 1.78 1.47-2.14 1.68e-09 2.26 1.88-2.7 1.07e-18 True False False True Female 1341 6444 GRCh37/hg19 P<=5e-08 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000480/ScoringFiles/ https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000480/ScoringFiles/ /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE174.1_C50_P_5e-08_MGI_20200608/all.tsv /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE174.1_C50_P_5e-08_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode174-1-gwas-catalog-r2019-05-03-x174-1-p-5e-08-mgi-20200608 prsweb-phecode174-1-gwas-catalog-r2019-05-03-x174-1-p-5e-08-mgi-20200608 PRSWEB_PHECODE174.1_GWAS-Catalog-r2019-05-03-X174.1_P_5e-08_MGI_20200608 P_5e-08 PRSWEB_PHECODE174.1_GWAS-Catalog-r2019-05-03-X174.1_P_5e-08_MGI_20200608 174.1 Breast cancer;Breast cancer (estrogen-receptor negative);Breast Cancer in BRCA1 mutation carriers;Breast cancer in BRCA2 mutation carriers Binary 136 unique SNPs MGI Michigan Genomics Initiative GWAS Hits GWAS Catalog (2019-05-03) 17529967;17529973;17529974;18326623;19330027;19330030;20453838;20852631;20872241;21263130;21424380;23354978;23535729;23535733;23544012;23544013;25751625;29058716;29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=17529967+17529973+17529974+18326623+19330027+19330030+20453838+20852631+20872241+21263130+21424380+23354978+23535729+23535733+23544012+23544013+25751625+29058716+29059683 62 5.2e-37 0.0207597 0.136 0.607 0.589-0.623 OR 3.06 2.04-4.6 3.06 2.04-4.6 2.35 1.71-3.24 2.35 1.71-3.24 2.21 1.79-2.74 2.21 1.79-2.74 2.26 1.93-2.65 2.26 1.93-2.65 1.9 1.68-2.16 1.9 1.68-2.16 1.45 1.2-1.77 0.000182 1.75 1.45-2.12 9.46e-09 2.68 2.23-3.21 1.95e-26 True False False True Female 1341 6444 GRCh37/hg19 P<=5e-08 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000485/ScoringFiles/ https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000485/ScoringFiles/ /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE174.1_GWAS-Catalog-r2019-05-03-X174.1_P_5e-08_MGI_20200608/all.tsv /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE174.1_GWAS-Catalog-r2019-05-03-X174.1_P_5e-08_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode174-1-onco-icogs-er-negative-brca-p-5e-08-mgi-20200608 prsweb-phecode174-1-onco-icogs-er-negative-brca-p-5e-08-mgi-20200608 PRSWEB_PHECODE174.1_Onco-iCOGS-ER-negative-BRCA_P_5e-08_MGI_20200608 P_5e-08 PRSWEB_PHECODE174.1_Onco-iCOGS-ER-negative-BRCA_P_5e-08_MGI_20200608 174.1 Breast cancer [female]; ER negative Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). MGI Michigan Genomics Initiative GWAS Hits Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 49 1e-13 0.00998487 0.139 0.564 0.547-0.58 OR 1.72 1.05-2.81 1.72 1.05-2.81 1.86 1.32-2.63 1.86 1.32-2.63 1.54 1.22-1.95 1.54 1.22-1.95 1.47 1.23-1.75 1.47 1.23-1.75 1.42 1.24-1.61 1.42 1.24-1.61 1.24 1.03-1.5 0.0224 1.6 1.34-1.91 2.42e-07 1.81 1.52-2.15 3.15e-11 True False False True Female 1341 6444 GRCh37/hg19 P<=5e-08 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000489/ScoringFiles/ https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000489/ScoringFiles/ /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE174.1_Onco-iCOGS-ER-negative-BRCA_P_5e-08_MGI_20200608/all.tsv /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE174.1_Onco-iCOGS-ER-negative-BRCA_P_5e-08_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode174-1-onco-icogs-er-positive-brca-p-5e-08-mgi-20200608 prsweb-phecode174-1-onco-icogs-er-positive-brca-p-5e-08-mgi-20200608 PRSWEB_PHECODE174.1_Onco-iCOGS-ER-positive-BRCA_P_5e-08_MGI_20200608 P_5e-08 PRSWEB_PHECODE174.1_Onco-iCOGS-ER-positive-BRCA_P_5e-08_MGI_20200608 174.1 Breast cancer [female]; ER positive Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). MGI Michigan Genomics Initiative GWAS Hits Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 257 2.8e-40 0.0284596 0.136 0.614 0.599-0.63 OR 2.35 1.51-3.66 2.35 1.51-3.66 2.38 1.73-3.26 2.38 1.73-3.26 2.19 1.77-2.71 2.19 1.77-2.71 2 1.69-2.35 2 1.69-2.35 1.85 1.63-2.1 1.85 1.63-2.1 1.27 1.04-1.55 0.0206 2.07 1.72-2.5 3.1e-14 2.65 2.21-3.18 5.02e-26 True False False True Female 1341 6444 GRCh37/hg19 P<=5e-08 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000497/ScoringFiles/ https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000497/ScoringFiles/ /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE174.1_Onco-iCOGS-ER-positive-BRCA_P_5e-08_MGI_20200608/all.tsv /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE174.1_Onco-iCOGS-ER-positive-BRCA_P_5e-08_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode174-1-onco-icogs-overall-brca-p-5e-08-mgi-20200608 prsweb-phecode174-1-onco-icogs-overall-brca-p-5e-08-mgi-20200608 PRSWEB_PHECODE174.1_Onco-iCOGS-Overall-BRCA_P_5e-08_MGI_20200608 P_5e-08 PRSWEB_PHECODE174.1_Onco-iCOGS-Overall-BRCA_P_5e-08_MGI_20200608 174.1 Breast cancer [female], Overall Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). MGI Michigan Genomics Initiative GWAS Hits Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 334 1.6e-47 0.0371755 0.136 0.625 0.609-0.641 OR 3.32 2.24-4.93 3.32 2.24-4.93 2.73 2.02-3.69 2.73 2.02-3.69 2.51 2.04-3.08 2.51 2.04-3.08 2.19 1.86-2.57 2.19 1.86-2.57 2.01 1.78-2.28 2.01 1.78-2.28 1.79 1.45-2.22 6.09e-08 2.5 2.05-3.07 4.81e-19 3.52 2.9-4.28 1.47e-36 True False False True Female 1341 6444 GRCh37/hg19 P<=5e-08 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000505/ScoringFiles/ https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000505/ScoringFiles/ /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE174.1_Onco-iCOGS-Overall-BRCA_P_5e-08_MGI_20200608/all.tsv /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE174.1_Onco-iCOGS-Overall-BRCA_P_5e-08_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode174-1-ukbb-saige-hrc-x174-1-p-5e-08-mgi-20200608 prsweb-phecode174-1-ukbb-saige-hrc-x174-1-p-5e-08-mgi-20200608 PRSWEB_PHECODE174.1_UKBB-SAIGE-HRC-X174.1_P_5e-08_MGI_20200608 P_5e-08 PRSWEB_PHECODE174.1_UKBB-SAIGE-HRC-X174.1_P_5e-08_MGI_20200608 174.1 Breast cancer [female] Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative GWAS Hits UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 41 3.6e-28 0.0127429 0.137 0.595 0.577-0.612 OR 1.8 1.12-2.91 1.8 1.12-2.91 1.87 1.33-2.63 1.87 1.33-2.63 1.77 1.41-2.22 1.77 1.41-2.22 1.77 1.5-2.1 1.77 1.5-2.1 1.79 1.58-2.03 1.79 1.58-2.03 1.33 1.09-1.61 0.00464 1.76 1.46-2.12 2.96e-09 2.43 2.03-2.91 1.61e-22 True False False True Female 1341 6444 GRCh37/hg19 P<=5e-08 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000513/ScoringFiles/ https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000513/ScoringFiles/ /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE174.1_UKBB-SAIGE-HRC-X174.1_P_5e-08_MGI_20200608/all.tsv /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE174.1_UKBB-SAIGE-HRC-X174.1_P_5e-08_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode174-1-icogs-er-negative-brca-p-5e-08-mgi-20200608 prsweb-phecode174-1-icogs-er-negative-brca-p-5e-08-mgi-20200608 PRSWEB_PHECODE174.1_iCOGS-ER-negative-BRCA_P_5e-08_MGI_20200608 P_5e-08 PRSWEB_PHECODE174.1_iCOGS-ER-negative-BRCA_P_5e-08_MGI_20200608 174.1 Breast cancer [female]; ER negative Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). MGI Michigan Genomics Initiative GWAS Hits Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 10 1.6e-11 0.00720804 0.139 0.55 0.533-0.566 OR 1.88 1.17-3.03 1.88 1.17-3.03 1.63 1.14-2.34 1.63 1.14-2.34 1.54 1.21-1.95 1.54 1.21-1.95 1.44 1.21-1.72 1.44 1.21-1.72 1.37 1.2-1.56 1.37 1.2-1.56 1.44 1.2-1.72 8.97e-05 1.41 1.17-1.69 0.000242 1.77 1.48-2.11 2.4e-10 True False False True Female 1341 6444 GRCh37/hg19 P<=5e-08 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000517/ScoringFiles/ https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000517/ScoringFiles/ /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE174.1_iCOGS-ER-negative-BRCA_P_5e-08_MGI_20200608/all.tsv /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE174.1_iCOGS-ER-negative-BRCA_P_5e-08_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode174-1-icogs-er-positive-brca-p-5e-08-mgi-20200608 prsweb-phecode174-1-icogs-er-positive-brca-p-5e-08-mgi-20200608 PRSWEB_PHECODE174.1_iCOGS-ER-positive-BRCA_P_5e-08_MGI_20200608 P_5e-08 PRSWEB_PHECODE174.1_iCOGS-ER-positive-BRCA_P_5e-08_MGI_20200608 174.1 Breast cancer [female]; ER positive Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). MGI Michigan Genomics Initiative GWAS Hits Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 86 1.2e-30 0.0196761 0.137 0.597 0.58-0.614 OR 2.28 1.46-3.56 2.28 1.46-3.56 2.25 1.64-3.11 2.25 1.64-3.11 1.88 1.51-2.35 1.88 1.51-2.35 2.01 1.71-2.37 2.01 1.71-2.37 1.73 1.52-1.96 1.73 1.52-1.96 1.42 1.17-1.73 0.000481 1.93 1.6-2.33 5.9e-12 2.49 2.08-2.99 4.41e-23 True False False True Female 1341 6444 GRCh37/hg19 P<=5e-08 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000525/ScoringFiles/ https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000525/ScoringFiles/ /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE174.1_iCOGS-ER-positive-BRCA_P_5e-08_MGI_20200608/all.tsv /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE174.1_iCOGS-ER-positive-BRCA_P_5e-08_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode174-1-icogs-overall-brca-p-5e-08-mgi-20200608 prsweb-phecode174-1-icogs-overall-brca-p-5e-08-mgi-20200608 PRSWEB_PHECODE174.1_iCOGS-Overall-BRCA_P_5e-08_MGI_20200608 P_5e-08 PRSWEB_PHECODE174.1_iCOGS-Overall-BRCA_P_5e-08_MGI_20200608 174.1 Breast cancer [female], Overall Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). MGI Michigan Genomics Initiative GWAS Hits Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 110 2.8e-37 0.021414 0.137 0.607 0.591-0.623 OR 2.51 1.63-3.86 2.51 1.63-3.86 2.56 1.88-3.48 2.56 1.88-3.48 2.35 1.91-2.89 2.35 1.91-2.89 1.97 1.67-2.32 1.97 1.67-2.32 1.88 1.66-2.13 1.88 1.66-2.13 1.5 1.23-1.83 6.86e-05 1.9 1.57-2.3 4.31e-11 2.74 2.28-3.29 2.97e-27 True False False True Female 1341 6444 GRCh37/hg19 P<=5e-08 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000533/ScoringFiles/ https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000533/ScoringFiles/ /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE174.1_iCOGS-Overall-BRCA_P_5e-08_MGI_20200608/all.tsv /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE174.1_iCOGS-Overall-BRCA_P_5e-08_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode174-1-20001-1002-pt-mgi-20200608 prsweb-phecode174-1-20001-1002-pt-mgi-20200608 PRSWEB_PHECODE174.1_20001-1002_PT_MGI_20200608 P&T PRSWEB_PHECODE174.1_20001-1002_PT_MGI_20200608 174.1 Cancer code, self-reported: breast cancer Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative P&T UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 68 3.2e-21 0.012988 0.138 0.58 0.563-0.597 OR 1.54 0.924-2.56 1.54 0.924-2.56 1.77 1.25-2.5 1.77 1.25-2.5 1.72 1.37-2.17 1.72 1.37-2.17 1.73 1.46-2.06 1.73 1.46-2.06 1.69 1.49-1.92 1.69 1.49-1.92 1.34 1.11-1.61 0.00244 1.51 1.26-1.82 1.04e-05 2.16 1.82-2.58 5.1e-18 True False False True Female 1341 6444 GRCh37/hg19 P<=6.31e-06 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000474/ScoringFiles/ https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000474/ScoringFiles/ /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE174.1_20001-1002_PT_MGI_20200608/all.tsv /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE174.1_20001-1002_PT_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode174-1-c3-breast-3-pt-mgi-20200608 prsweb-phecode174-1-c3-breast-3-pt-mgi-20200608 PRSWEB_PHECODE174.1_C3-BREAST-3_PT_MGI_20200608 P&T PRSWEB_PHECODE174.1_C3-BREAST-3_PT_MGI_20200608 174.1 Malignant neoplasm of breast Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative P&T UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 120 1.1e-28 0.014399 0.137 0.595 0.578-0.611 OR 2.31 1.47-3.61 2.31 1.47-3.61 2.08 1.5-2.89 2.08 1.5-2.89 1.83 1.46-2.29 1.83 1.46-2.29 1.83 1.54-2.16 1.83 1.54-2.16 1.76 1.55-2 1.76 1.55-2 1.37 1.13-1.66 0.00147 1.68 1.4-2.02 3.39e-08 2.37 1.99-2.83 1.5e-21 True False False True Female 1341 6444 GRCh37/hg19 P<=1.26e-05 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000478/ScoringFiles/ https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000478/ScoringFiles/ /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE174.1_C3-BREAST-3_PT_MGI_20200608/all.tsv /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE174.1_C3-BREAST-3_PT_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode174-1-c50-pt-mgi-20200608 prsweb-phecode174-1-c50-pt-mgi-20200608 PRSWEB_PHECODE174.1_C50_PT_MGI_20200608 P&T PRSWEB_PHECODE174.1_C50_PT_MGI_20200608 174.1 Diagnoses - main ICD10: C50 Malignant neoplasm of breast Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative P&T UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 42 1.5e-23 0.0126612 0.138 0.584 0.568-0.601 OR 1.43 0.853-2.41 1.43 0.853-2.41 1.85 1.32-2.61 1.85 1.32-2.61 1.72 1.37-2.16 1.72 1.37-2.16 1.69 1.43-2.01 1.69 1.43-2.01 1.69 1.49-1.92 1.69 1.49-1.92 1.19 0.982-1.44 0.0757 1.58 1.32-1.9 5.95e-07 2.12 1.78-2.52 2.34e-17 True False False True Female 1341 6444 GRCh37/hg19 P<=1.58e-06 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000482/ScoringFiles/ https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000482/ScoringFiles/ /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE174.1_C50_PT_MGI_20200608/all.tsv /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE174.1_C50_PT_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode174-1-d05-pt-mgi-20200608 prsweb-phecode174-1-d05-pt-mgi-20200608 PRSWEB_PHECODE174.1_D05_PT_MGI_20200608 P&T PRSWEB_PHECODE174.1_D05_PT_MGI_20200608 174.1 Diagnoses - main ICD10: D05 Carcinoma in situ of breast Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative P&T UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 25 0.00014 0.00212228 0.139 0.52 0.504-0.538 OR 1.39 0.817-2.36 1.39 0.817-2.36 1.26 0.85-1.86 1.26 0.85-1.86 1.12 0.862-1.45 1.12 0.862-1.45 1.3 1.08-1.56 1.3 1.08-1.56 1.2 1.05-1.37 1.2 1.05-1.37 1.06 0.891-1.26 0.506 1.21 1.02-1.43 0.0323 1.3 1.1-1.54 0.00217 True False False True Female 1341 6444 GRCh37/hg19 P<=7.94e-06 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000484/ScoringFiles/ https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000484/ScoringFiles/ /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE174.1_D05_PT_MGI_20200608/all.tsv /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE174.1_D05_PT_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode174-1-gwas-catalog-r2019-05-03-x174-1-pt-mgi-20200608 prsweb-phecode174-1-gwas-catalog-r2019-05-03-x174-1-pt-mgi-20200608 PRSWEB_PHECODE174.1_GWAS-Catalog-r2019-05-03-X174.1_PT_MGI_20200608 P&T PRSWEB_PHECODE174.1_GWAS-Catalog-r2019-05-03-X174.1_PT_MGI_20200608 174.1 Breast cancer;Breast cancer (estrogen-receptor negative);Breast Cancer in BRCA1 mutation carriers;Breast cancer in BRCA2 mutation carriers Binary 136 unique SNPs MGI Michigan Genomics Initiative P&T GWAS Catalog (2019-05-03) 17529967;17529973;17529974;18326623;19330027;19330030;20453838;20852631;20872241;21263130;21424380;23354978;23535729;23535733;23544012;23544013;25751625;29058716;29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=17529967+17529973+17529974+18326623+19330027+19330030+20453838+20852631+20872241+21263130+21424380+23354978+23535729+23535733+23544012+23544013+25751625+29058716+29059683 62 5.2e-37 0.0207597 0.136 0.607 0.589-0.623 OR 3.06 2.04-4.6 3.06 2.04-4.6 2.35 1.71-3.24 2.35 1.71-3.24 2.21 1.79-2.74 2.21 1.79-2.74 2.26 1.93-2.65 2.26 1.93-2.65 1.9 1.68-2.16 1.9 1.68-2.16 1.45 1.2-1.77 0.000182 1.75 1.45-2.12 9.46e-09 2.68 2.23-3.21 1.95e-26 True False False True Female 1341 6444 GRCh37/hg19 P<=3.16e-09 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000487/ScoringFiles/ https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000487/ScoringFiles/ /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE174.1_GWAS-Catalog-r2019-05-03-X174.1_PT_MGI_20200608/all.tsv /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE174.1_GWAS-Catalog-r2019-05-03-X174.1_PT_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode174-1-onco-icogs-er-negative-brca-pt-mgi-20200608 prsweb-phecode174-1-onco-icogs-er-negative-brca-pt-mgi-20200608 PRSWEB_PHECODE174.1_Onco-iCOGS-ER-negative-BRCA_PT_MGI_20200608 P&T PRSWEB_PHECODE174.1_Onco-iCOGS-ER-negative-BRCA_PT_MGI_20200608 174.1 Breast cancer [female]; ER negative Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). MGI Michigan Genomics Initiative P&T Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 217 1e-18 0.0104166 0.138 0.576 0.559-0.593 OR 1.84 1.14-2.97 1.84 1.14-2.97 1.77 1.26-2.49 1.77 1.26-2.49 1.79 1.43-2.24 1.79 1.43-2.24 1.56 1.31-1.85 1.56 1.31-1.85 1.58 1.39-1.8 1.58 1.39-1.8 1.36 1.13-1.64 0.00107 1.5 1.25-1.8 1.5e-05 2.03 1.7-2.43 3.19e-15 True False False True Female 1341 6444 GRCh37/hg19 P<=1.58e-05 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000493/ScoringFiles/ https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000493/ScoringFiles/ /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE174.1_Onco-iCOGS-ER-negative-BRCA_PT_MGI_20200608/all.tsv /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE174.1_Onco-iCOGS-ER-negative-BRCA_PT_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode174-1-onco-icogs-er-positive-brca-pt-mgi-20200608 prsweb-phecode174-1-onco-icogs-er-positive-brca-pt-mgi-20200608 PRSWEB_PHECODE174.1_Onco-iCOGS-ER-positive-BRCA_PT_MGI_20200608 P&T PRSWEB_PHECODE174.1_Onco-iCOGS-ER-positive-BRCA_PT_MGI_20200608 174.1 Breast cancer [female]; ER positive Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). MGI Michigan Genomics Initiative P&T Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 1142 8.1e-45 0.0356047 0.136 0.621 0.605-0.638 OR 2.7 1.77-4.1 2.7 1.77-4.1 2.84 2.11-3.84 2.84 2.11-3.84 2.34 1.9-2.89 2.34 1.9-2.89 2.23 1.9-2.62 2.23 1.9-2.62 2.1 1.85-2.38 2.1 1.85-2.38 1.41 1.15-1.72 0.000941 1.84 1.52-2.23 5.24e-10 2.93 2.44-3.52 4.4e-31 True False False True Female 1341 6444 GRCh37/hg19 P<=7.94e-05 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000501/ScoringFiles/ https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000501/ScoringFiles/ /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE174.1_Onco-iCOGS-ER-positive-BRCA_PT_MGI_20200608/all.tsv /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE174.1_Onco-iCOGS-ER-positive-BRCA_PT_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode174-1-onco-icogs-overall-brca-pt-mgi-20200608 prsweb-phecode174-1-onco-icogs-overall-brca-pt-mgi-20200608 PRSWEB_PHECODE174.1_Onco-iCOGS-Overall-BRCA_PT_MGI_20200608 P&T PRSWEB_PHECODE174.1_Onco-iCOGS-Overall-BRCA_PT_MGI_20200608 174.1 Breast cancer [female], Overall Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). MGI Michigan Genomics Initiative P&T Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 3038 2.2e-53 0.0410376 0.135 0.635 0.618-0.651 OR 2.84 1.88-4.28 2.84 1.88-4.28 2.69 1.99-3.65 2.69 1.99-3.65 2.63 2.15-3.23 2.63 2.15-3.23 2.58 2.2-3.01 2.58 2.2-3.01 2.24 1.98-2.54 2.24 1.98-2.54 1.24 1-1.52 0.045 2 1.65-2.43 1.99e-12 3.15 2.62-3.78 3.88e-34 True False False True Female 1341 6444 GRCh37/hg19 P<=0.000398 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000509/ScoringFiles/ https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000509/ScoringFiles/ /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE174.1_Onco-iCOGS-Overall-BRCA_PT_MGI_20200608/all.tsv /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE174.1_Onco-iCOGS-Overall-BRCA_PT_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode174-1-ukbb-saige-hrc-x174-1-pt-mgi-20200608 prsweb-phecode174-1-ukbb-saige-hrc-x174-1-pt-mgi-20200608 PRSWEB_PHECODE174.1_UKBB-SAIGE-HRC-X174.1_PT_MGI_20200608 P&T PRSWEB_PHECODE174.1_UKBB-SAIGE-HRC-X174.1_PT_MGI_20200608 174.1 Breast cancer [female] Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative P&T UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 84 2.8e-33 0.0182677 0.137 0.605 0.588-0.621 OR 2.09 1.31-3.32 2.09 1.31-3.32 2.33 1.7-3.21 2.33 1.7-3.21 1.75 1.4-2.2 1.75 1.4-2.2 1.74 1.47-2.06 1.74 1.47-2.06 1.93 1.7-2.19 1.93 1.7-2.19 1.49 1.22-1.82 0.000111 1.97 1.63-2.39 4.09e-12 2.85 2.37-3.43 5.12e-29 True False False True Female 1341 6444 GRCh37/hg19 P<=1.58e-06 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000515/ScoringFiles/ https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000515/ScoringFiles/ /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE174.1_UKBB-SAIGE-HRC-X174.1_PT_MGI_20200608/all.tsv /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE174.1_UKBB-SAIGE-HRC-X174.1_PT_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode174-1-icogs-er-negative-brca-pt-mgi-20200608 prsweb-phecode174-1-icogs-er-negative-brca-pt-mgi-20200608 PRSWEB_PHECODE174.1_iCOGS-ER-negative-BRCA_PT_MGI_20200608 P&T PRSWEB_PHECODE174.1_iCOGS-ER-negative-BRCA_PT_MGI_20200608 174.1 Breast cancer [female]; ER negative Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). MGI Michigan Genomics Initiative P&T Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 9 6.5e-11 0.00741743 0.139 0.548 0.53-0.564 OR 1.88 1.18-2.99 1.88 1.18-2.99 1.76 1.25-2.49 1.76 1.25-2.49 1.5 1.18-1.9 1.5 1.18-1.9 1.6 1.35-1.9 1.6 1.35-1.9 1.31 1.15-1.5 1.31 1.15-1.5 1.44 1.2-1.72 7.32e-05 1.4 1.17-1.68 0.000253 1.68 1.41-2 5.91e-09 True False False True Female 1341 6444 GRCh37/hg19 P<=7.94e-09 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000521/ScoringFiles/ https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000521/ScoringFiles/ /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE174.1_iCOGS-ER-negative-BRCA_PT_MGI_20200608/all.tsv /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE174.1_iCOGS-ER-negative-BRCA_PT_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode174-1-icogs-er-positive-brca-pt-mgi-20200608 prsweb-phecode174-1-icogs-er-positive-brca-pt-mgi-20200608 PRSWEB_PHECODE174.1_iCOGS-ER-positive-BRCA_PT_MGI_20200608 P&T PRSWEB_PHECODE174.1_iCOGS-ER-positive-BRCA_PT_MGI_20200608 174.1 Breast cancer [female]; ER positive Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). MGI Michigan Genomics Initiative P&T Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 310 1.2e-30 0.0240026 0.137 0.597 0.58-0.612 OR 2.98 1.98-4.47 2.98 1.98-4.47 2.46 1.81-3.35 2.46 1.81-3.35 2.38 1.93-2.93 2.38 1.93-2.93 1.99 1.69-2.35 1.99 1.69-2.35 1.77 1.56-2.01 1.77 1.56-2.01 1.4 1.16-1.7 0.00063 1.81 1.5-2.18 5.63e-10 2.47 2.06-2.95 5.58e-23 True False False True Female 1341 6444 GRCh37/hg19 P<=2.51e-05 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000529/ScoringFiles/ https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000529/ScoringFiles/ /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE174.1_iCOGS-ER-positive-BRCA_PT_MGI_20200608/all.tsv /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE174.1_iCOGS-ER-positive-BRCA_PT_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode174-1-icogs-overall-brca-pt-mgi-20200608 prsweb-phecode174-1-icogs-overall-brca-pt-mgi-20200608 PRSWEB_PHECODE174.1_iCOGS-Overall-BRCA_PT_MGI_20200608 P&T PRSWEB_PHECODE174.1_iCOGS-Overall-BRCA_PT_MGI_20200608 174.1 Breast cancer [female], Overall Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). MGI Michigan Genomics Initiative P&T Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 363 8e-38 0.0258032 0.136 0.609 0.592-0.626 OR 3.44 2.31-5.13 3.44 2.31-5.13 2.53 1.85-3.45 2.53 1.85-3.45 2.04 1.64-2.54 2.04 1.64-2.54 1.99 1.69-2.35 1.99 1.69-2.35 1.91 1.68-2.16 1.91 1.68-2.16 1.28 1.05-1.56 0.0161 1.89 1.57-2.29 2.86e-11 2.65 2.21-3.17 2.92e-26 True False False True Female 1341 6444 GRCh37/hg19 P<=2e-05 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000537/ScoringFiles/ https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000537/ScoringFiles/ /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE174.1_iCOGS-Overall-BRCA_PT_MGI_20200608/all.tsv /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE174.1_iCOGS-Overall-BRCA_PT_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode174-1-20001-1002-prs-cs-mgi-20200608 prsweb-phecode174-1-20001-1002-prs-cs-mgi-20200608 PRSWEB_PHECODE174.1_20001-1002_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE174.1_20001-1002_PRS-CS_MGI_20200608 174.1 Cancer code, self-reported: breast cancer Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative PRS-CS UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1111495 1.3e-18 0.0138568 0.138 0.576 0.56-0.592 OR 1.6 0.981-2.62 1.6 0.981-2.62 1.86 1.32-2.63 1.86 1.32-2.63 1.77 1.41-2.22 1.77 1.41-2.22 1.71 1.45-2.03 1.71 1.45-2.03 1.55 1.36-1.76 1.55 1.36-1.76 1.22 1.01-1.48 0.0345 1.54 1.29-1.85 2.14e-06 1.94 1.63-2.31 6.21e-14 True False False True Female 1341 6444 GRCh37/hg19 auto https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000473/ScoringFiles/ https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000473/ScoringFiles/ /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE174.1_20001-1002_PRS-CS_MGI_20200608/all.tsv /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE174.1_20001-1002_PRS-CS_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode174-1-c3-breast-3-prs-cs-mgi-20200608 prsweb-phecode174-1-c3-breast-3-prs-cs-mgi-20200608 PRSWEB_PHECODE174.1_C3-BREAST-3_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE174.1_C3-BREAST-3_PRS-CS_MGI_20200608 174.1 Malignant neoplasm of breast Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative PRS-CS UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1111495 3.7e-21 0.0176437 0.138 0.581 0.564-0.597 OR 2.17 1.38-3.41 2.17 1.38-3.41 2.23 1.62-3.07 2.23 1.62-3.07 1.89 1.52-2.35 1.89 1.52-2.35 1.76 1.49-2.08 1.76 1.49-2.08 1.54 1.36-1.75 1.54 1.36-1.75 1.57 1.3-1.89 2.75e-06 1.67 1.38-2.01 6.92e-08 2.19 1.83-2.62 9.38e-18 True False False True Female 1341 6444 GRCh37/hg19 auto https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000477/ScoringFiles/ https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000477/ScoringFiles/ /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE174.1_C3-BREAST-3_PRS-CS_MGI_20200608/all.tsv /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE174.1_C3-BREAST-3_PRS-CS_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode174-1-c50-prs-cs-mgi-20200608 prsweb-phecode174-1-c50-prs-cs-mgi-20200608 PRSWEB_PHECODE174.1_C50_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE174.1_C50_PRS-CS_MGI_20200608 174.1 Diagnoses - main ICD10: C50 Malignant neoplasm of breast Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative PRS-CS UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1111495 7.1e-20 0.0136922 0.138 0.578 0.56-0.596 OR 2.03 1.29-3.2 2.03 1.29-3.2 2.12 1.53-2.92 2.12 1.53-2.92 1.92 1.54-2.4 1.92 1.54-2.4 1.73 1.47-2.05 1.73 1.47-2.05 1.5 1.32-1.7 1.5 1.32-1.7 1.43 1.18-1.73 0.000227 1.8 1.5-2.16 3.58e-10 2.12 1.77-2.53 2.15e-16 True False False True Female 1341 6444 GRCh37/hg19 auto https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000481/ScoringFiles/ https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000481/ScoringFiles/ /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE174.1_C50_PRS-CS_MGI_20200608/all.tsv /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE174.1_C50_PRS-CS_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode174-1-d05-prs-cs-mgi-20200608 prsweb-phecode174-1-d05-prs-cs-mgi-20200608 PRSWEB_PHECODE174.1_D05_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE174.1_D05_PRS-CS_MGI_20200608 174.1 Diagnoses - main ICD10: D05 Carcinoma in situ of breast Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative PRS-CS UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1107790 0.073 0.00164358 0.14 0.519 0.503-0.536 OR 1.16 0.667-2.02 1.16 0.667-2.02 1.25 0.853-1.84 1.25 0.853-1.84 1.18 0.912-1.51 1.18 0.912-1.51 1.06 0.871-1.28 1.06 0.871-1.28 1.19 1.04-1.36 1.19 1.04-1.36 0.887 0.745-1.06 0.176 1.04 0.878-1.23 0.652 1.16 0.984-1.37 0.0781 False False False False Female 1341 6444 GRCh37/hg19 auto 2020-06-08 prsweb-phecode174-1-onco-icogs-er-negative-brca-prs-cs-mgi-20200608 prsweb-phecode174-1-onco-icogs-er-negative-brca-prs-cs-mgi-20200608 PRSWEB_PHECODE174.1_Onco-iCOGS-ER-negative-BRCA_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE174.1_Onco-iCOGS-ER-negative-BRCA_PRS-CS_MGI_20200608 174.1 Breast cancer [female]; ER negative Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). MGI Michigan Genomics Initiative PRS-CS Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 1119140 5e-19 0.0139296 0.138 0.578 0.56-0.594 OR 1.8 1.13-2.88 1.8 1.13-2.88 1.75 1.24-2.48 1.75 1.24-2.48 1.68 1.33-2.11 1.68 1.33-2.11 1.66 1.39-1.97 1.66 1.39-1.97 1.54 1.35-1.76 1.54 1.35-1.76 1.11 0.917-1.33 0.291 1.51 1.27-1.81 5.1e-06 1.8 1.51-2.15 5.43e-11 True False False True Female 1341 6444 GRCh37/hg19 auto https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000491/ScoringFiles/ https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000491/ScoringFiles/ /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE174.1_Onco-iCOGS-ER-negative-BRCA_PRS-CS_MGI_20200608/all.tsv /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE174.1_Onco-iCOGS-ER-negative-BRCA_PRS-CS_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode174-1-onco-icogs-er-positive-brca-prs-cs-mgi-20200608 prsweb-phecode174-1-onco-icogs-er-positive-brca-prs-cs-mgi-20200608 PRSWEB_PHECODE174.1_Onco-iCOGS-ER-positive-BRCA_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE174.1_Onco-iCOGS-ER-positive-BRCA_PRS-CS_MGI_20200608 174.1 Breast cancer [female]; ER positive Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). MGI Michigan Genomics Initiative PRS-CS Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 1119140 4.7e-59 0.044483 0.134 0.643 0.627-0.658 OR 3.71 2.52-5.47 3.71 2.52-5.47 3.22 2.41-4.31 3.22 2.41-4.31 2.81 2.3-3.45 2.81 2.3-3.45 2.71 2.32-3.17 2.71 2.32-3.17 2.36 2.08-2.68 2.36 2.08-2.68 1.4 1.14-1.72 0.00143 1.99 1.63-2.42 1.02e-11 3.38 2.81-4.07 1.41e-37 True False False True Female 1341 6444 GRCh37/hg19 auto https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000499/ScoringFiles/ https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000499/ScoringFiles/ /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE174.1_Onco-iCOGS-ER-positive-BRCA_PRS-CS_MGI_20200608/all.tsv /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE174.1_Onco-iCOGS-ER-positive-BRCA_PRS-CS_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode174-1-onco-icogs-overall-brca-prs-cs-mgi-20200608 prsweb-phecode174-1-onco-icogs-overall-brca-prs-cs-mgi-20200608 PRSWEB_PHECODE174.1_Onco-iCOGS-Overall-BRCA_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE174.1_Onco-iCOGS-Overall-BRCA_PRS-CS_MGI_20200608 174.1 Breast cancer [female], Overall Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). MGI Michigan Genomics Initiative PRS-CS Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 1119140 1e-65 0.0523367 0.133 0.651 0.635-0.666 OR 3.22 2.15-4.81 3.22 2.15-4.81 3.62 2.72-4.81 3.62 2.72-4.81 3.06 2.5-3.74 3.06 2.5-3.74 2.79 2.39-3.27 2.79 2.39-3.27 2.55 2.25-2.89 2.55 2.25-2.89 1.44 1.17-1.77 0.000634 1.91 1.57-2.33 1.79e-10 3.61 2.99-4.35 5.43e-41 True False False True Female 1341 6444 GRCh37/hg19 auto https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000507/ScoringFiles/ https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000507/ScoringFiles/ /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE174.1_Onco-iCOGS-Overall-BRCA_PRS-CS_MGI_20200608/all.tsv /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE174.1_Onco-iCOGS-Overall-BRCA_PRS-CS_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode174-1-ukbb-saige-hrc-x174-1-prs-cs-mgi-20200608 prsweb-phecode174-1-ukbb-saige-hrc-x174-1-prs-cs-mgi-20200608 PRSWEB_PHECODE174.1_UKBB-SAIGE-HRC-X174.1_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE174.1_UKBB-SAIGE-HRC-X174.1_PRS-CS_MGI_20200608 174.1 Breast cancer [female] Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative PRS-CS UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1119237 2.1e-26 0.0189124 0.137 0.59 0.573-0.607 OR 1.79 1.12-2.86 1.79 1.12-2.86 2.41 1.77-3.3 2.41 1.77-3.3 2.13 1.72-2.64 2.13 1.72-2.64 1.94 1.64-2.28 1.94 1.64-2.28 1.86 1.64-2.11 1.86 1.64-2.11 1.26 1.04-1.52 0.016 1.39 1.15-1.67 0.000588 2.25 1.89-2.67 4.05e-20 True False False True Female 1341 6444 GRCh37/hg19 auto https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000514/ScoringFiles/ https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000514/ScoringFiles/ /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE174.1_UKBB-SAIGE-HRC-X174.1_PRS-CS_MGI_20200608/all.tsv /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE174.1_UKBB-SAIGE-HRC-X174.1_PRS-CS_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode174-1-icogs-er-negative-brca-prs-cs-mgi-20200608 prsweb-phecode174-1-icogs-er-negative-brca-prs-cs-mgi-20200608 PRSWEB_PHECODE174.1_iCOGS-ER-negative-BRCA_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE174.1_iCOGS-ER-negative-BRCA_PRS-CS_MGI_20200608 174.1 Breast cancer [female]; ER negative Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). MGI Michigan Genomics Initiative PRS-CS Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 1115376 4.2e-06 0.0021514 0.139 0.539 0.52-0.556 OR 1.51 0.907-2.51 1.51 0.907-2.51 1.39 0.952-2.02 1.39 0.952-2.02 1.51 1.19-1.92 1.51 1.19-1.92 1.36 1.14-1.63 1.36 1.14-1.63 1.32 1.16-1.5 1.32 1.16-1.5 1.04 0.874-1.25 0.64 1.16 0.972-1.37 0.101 1.4 1.18-1.65 8.92e-05 True False False True Female 1341 6444 GRCh37/hg19 auto https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000519/ScoringFiles/ https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000519/ScoringFiles/ /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE174.1_iCOGS-ER-negative-BRCA_PRS-CS_MGI_20200608/all.tsv /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE174.1_iCOGS-ER-negative-BRCA_PRS-CS_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode174-1-icogs-er-positive-brca-prs-cs-mgi-20200608 prsweb-phecode174-1-icogs-er-positive-brca-prs-cs-mgi-20200608 PRSWEB_PHECODE174.1_iCOGS-ER-positive-BRCA_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE174.1_iCOGS-ER-positive-BRCA_PRS-CS_MGI_20200608 174.1 Breast cancer [female]; ER positive Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). MGI Michigan Genomics Initiative PRS-CS Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 1115436 4.2e-39 0.0285053 0.136 0.613 0.595-0.63 OR 3.75 2.55-5.51 3.75 2.55-5.51 3.19 2.39-4.26 3.19 2.39-4.26 2.51 2.04-3.08 2.51 2.04-3.08 2.25 1.92-2.64 2.25 1.92-2.64 2.04 1.8-2.31 2.04 1.8-2.31 1.2 0.982-1.46 0.0755 1.67 1.39-2.02 8.09e-08 2.63 2.2-3.14 8.17e-27 True False False True Female 1341 6444 GRCh37/hg19 auto https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000527/ScoringFiles/ https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000527/ScoringFiles/ /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE174.1_iCOGS-ER-positive-BRCA_PRS-CS_MGI_20200608/all.tsv /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE174.1_iCOGS-ER-positive-BRCA_PRS-CS_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode174-1-icogs-overall-brca-prs-cs-mgi-20200608 prsweb-phecode174-1-icogs-overall-brca-prs-cs-mgi-20200608 PRSWEB_PHECODE174.1_iCOGS-Overall-BRCA_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE174.1_iCOGS-Overall-BRCA_PRS-CS_MGI_20200608 174.1 Breast cancer [female], Overall Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). MGI Michigan Genomics Initiative PRS-CS Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 1115484 1.3e-45 0.0294967 0.135 0.622 0.605-0.638 OR 3.43 2.32-5.05 3.43 2.32-5.05 2.95 2.2-3.96 2.95 2.2-3.96 2.51 2.05-3.09 2.51 2.05-3.09 2.34 1.99-2.74 2.34 1.99-2.74 2.14 1.89-2.42 2.14 1.89-2.42 1.33 1.09-1.63 0.00609 1.9 1.57-2.31 4.88e-11 3.01 2.51-3.61 2.05e-32 True False False True Female 1341 6444 GRCh37/hg19 auto https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000535/ScoringFiles/ https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000535/ScoringFiles/ /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE174.1_iCOGS-Overall-BRCA_PRS-CS_MGI_20200608/all.tsv /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE174.1_iCOGS-Overall-BRCA_PRS-CS_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode174-1-20001-1002-lassosum-mgi-20200608 prsweb-phecode174-1-20001-1002-lassosum-mgi-20200608 PRSWEB_PHECODE174.1_20001-1002_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE174.1_20001-1002_LASSOSUM_MGI_20200608 174.1 Cancer code, self-reported: breast cancer Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative lassosum UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 30041 7.8e-22 0.0208462 0.138 0.586 0.57-0.603 OR 1.59 0.962-2.62 1.59 0.962-2.62 1.46 1.01-2.1 1.46 1.01-2.1 1.66 1.32-2.09 1.66 1.32-2.09 1.73 1.46-2.05 1.73 1.46-2.05 1.75 1.54-1.98 1.75 1.54-1.98 1.26 1.05-1.52 0.0156 1.51 1.25-1.81 1.16e-05 2.19 1.84-2.61 8.59e-19 True False False True Female 1341 6444 GRCh37/hg19 s=0.5;Lambda=0.01438 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000475/ScoringFiles/ https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000475/ScoringFiles/ /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE174.1_20001-1002_LASSOSUM_MGI_20200608/all.tsv /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE174.1_20001-1002_LASSOSUM_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode174-1-c3-breast-3-lassosum-mgi-20200608 prsweb-phecode174-1-c3-breast-3-lassosum-mgi-20200608 PRSWEB_PHECODE174.1_C3-BREAST-3_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE174.1_C3-BREAST-3_LASSOSUM_MGI_20200608 174.1 Malignant neoplasm of breast Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative lassosum UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 2267 3.4e-32 0.0241262 0.137 0.6 0.584-0.616 OR 2.37 1.54-3.65 2.37 1.54-3.65 2.08 1.5-2.88 2.08 1.5-2.88 2 1.61-2.49 2 1.61-2.49 1.84 1.56-2.18 1.84 1.56-2.18 1.95 1.72-2.21 1.95 1.72-2.21 1.27 1.04-1.54 0.0167 1.59 1.32-1.92 1.02e-06 2.5 2.09-2.97 1.61e-24 True False False True Female 1341 6444 GRCh37/hg19 s=0.5;Lambda=0.01833 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000479/ScoringFiles/ https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000479/ScoringFiles/ /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE174.1_C3-BREAST-3_LASSOSUM_MGI_20200608/all.tsv /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE174.1_C3-BREAST-3_LASSOSUM_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode174-1-c50-lassosum-mgi-20200608 prsweb-phecode174-1-c50-lassosum-mgi-20200608 PRSWEB_PHECODE174.1_C50_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE174.1_C50_LASSOSUM_MGI_20200608 174.1 Diagnoses - main ICD10: C50 Malignant neoplasm of breast Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative lassosum UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 4047 3e-28 0.0173004 0.137 0.595 0.579-0.61 OR 2.05 1.3-3.24 2.05 1.3-3.24 1.76 1.24-2.49 1.76 1.24-2.49 1.79 1.43-2.23 1.79 1.43-2.23 1.79 1.52-2.12 1.79 1.52-2.12 1.82 1.61-2.07 1.82 1.61-2.07 1.4 1.15-1.7 0.000826 1.82 1.51-2.2 4.09e-10 2.54 2.12-3.04 3.77e-24 True False False True Female 1341 6444 GRCh37/hg19 s=0.5;Lambda=0.01833 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000483/ScoringFiles/ https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000483/ScoringFiles/ /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE174.1_C50_LASSOSUM_MGI_20200608/all.tsv /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE174.1_C50_LASSOSUM_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode174-1-d05-lassosum-mgi-20200608 prsweb-phecode174-1-d05-lassosum-mgi-20200608 PRSWEB_PHECODE174.1_D05_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE174.1_D05_LASSOSUM_MGI_20200608 174.1 Diagnoses - main ICD10: D05 Carcinoma in situ of breast Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative lassosum UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 29211 0.093 0.00337863 0.14 0.515 0.498-0.532 OR 1.36 0.802-2.32 1.36 0.802-2.32 1.69 1.19-2.42 1.69 1.19-2.42 1.27 0.988-1.64 1.27 0.988-1.64 1.23 1.02-1.48 1.23 1.02-1.48 1.06 0.927-1.22 1.06 0.927-1.22 0.99 0.835-1.18 0.911 1.07 0.9-1.26 0.46 1.07 0.909-1.27 0.399 False False False False Female 1341 6444 GRCh37/hg19 s=1;Lambda=0.03793 2020-06-08 prsweb-phecode174-1-onco-icogs-er-negative-brca-lassosum-mgi-20200608 prsweb-phecode174-1-onco-icogs-er-negative-brca-lassosum-mgi-20200608 PRSWEB_PHECODE174.1_Onco-iCOGS-ER-negative-BRCA_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE174.1_Onco-iCOGS-ER-negative-BRCA_LASSOSUM_MGI_20200608 174.1 Breast cancer [female]; ER negative Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). MGI Michigan Genomics Initiative lassosum Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 18866 2.4e-17 0.0136313 0.138 0.571 0.555-0.588 OR 1.87 1.16-3.01 1.87 1.16-3.01 1.59 1.11-2.28 1.59 1.11-2.28 1.67 1.32-2.11 1.67 1.32-2.11 1.56 1.31-1.86 1.56 1.31-1.86 1.55 1.37-1.77 1.55 1.37-1.77 1.15 0.949-1.38 0.157 1.53 1.28-1.83 3.05e-06 1.91 1.61-2.28 2.69e-13 True False False True Female 1341 6444 GRCh37/hg19 s=0.5;Lambda=0.006952 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000495/ScoringFiles/ https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000495/ScoringFiles/ /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE174.1_Onco-iCOGS-ER-negative-BRCA_LASSOSUM_MGI_20200608/all.tsv /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE174.1_Onco-iCOGS-ER-negative-BRCA_LASSOSUM_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode174-1-onco-icogs-er-positive-brca-lassosum-mgi-20200608 prsweb-phecode174-1-onco-icogs-er-positive-brca-lassosum-mgi-20200608 PRSWEB_PHECODE174.1_Onco-iCOGS-ER-positive-BRCA_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE174.1_Onco-iCOGS-ER-positive-BRCA_LASSOSUM_MGI_20200608 174.1 Breast cancer [female]; ER positive Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). MGI Michigan Genomics Initiative lassosum Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 61635 5.1e-54 0.0433122 0.135 0.634 0.618-0.65 OR 4.03 2.78-5.85 4.03 2.78-5.85 3.48 2.63-4.62 3.48 2.63-4.62 2.86 2.34-3.48 2.86 2.34-3.48 2.54 2.17-2.97 2.54 2.17-2.97 2.2 1.94-2.49 2.2 1.94-2.49 1.55 1.26-1.9 2.84e-05 2 1.64-2.44 6.19e-12 3.26 2.7-3.94 4.49e-35 True False False True Female 1341 6444 GRCh37/hg19 s=0.5;Lambda=0.008859 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000503/ScoringFiles/ https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000503/ScoringFiles/ /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE174.1_Onco-iCOGS-ER-positive-BRCA_LASSOSUM_MGI_20200608/all.tsv /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE174.1_Onco-iCOGS-ER-positive-BRCA_LASSOSUM_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode174-1-onco-icogs-overall-brca-lassosum-mgi-20200608 prsweb-phecode174-1-onco-icogs-overall-brca-lassosum-mgi-20200608 PRSWEB_PHECODE174.1_Onco-iCOGS-Overall-BRCA_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE174.1_Onco-iCOGS-Overall-BRCA_LASSOSUM_MGI_20200608 174.1 Breast cancer [female], Overall Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). MGI Michigan Genomics Initiative lassosum Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 118388 1.2e-58 0.0505337 0.134 0.641 0.625-0.656 OR 2.48 1.63-3.77 2.48 1.63-3.77 2.93 2.18-3.93 2.93 2.18-3.93 3.03 2.49-3.69 3.03 2.49-3.69 2.94 2.52-3.44 2.94 2.52-3.44 2.36 2.09-2.68 2.36 2.09-2.68 1.62 1.32-1.99 5.28e-06 1.98 1.62-2.42 2.99e-11 3.49 2.89-4.22 2.71e-38 True False False True Female 1341 6444 GRCh37/hg19 s=0.5;Lambda=0.004281 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000511/ScoringFiles/ https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000511/ScoringFiles/ /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE174.1_Onco-iCOGS-Overall-BRCA_LASSOSUM_MGI_20200608/all.tsv /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE174.1_Onco-iCOGS-Overall-BRCA_LASSOSUM_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode174-1-ukbb-saige-hrc-x174-1-lassosum-mgi-20200608 prsweb-phecode174-1-ukbb-saige-hrc-x174-1-lassosum-mgi-20200608 PRSWEB_PHECODE174.1_UKBB-SAIGE-HRC-X174.1_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE174.1_UKBB-SAIGE-HRC-X174.1_LASSOSUM_MGI_20200608 174.1 Breast cancer [female] Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative lassosum UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 6977 2.4e-36 0.0260906 0.137 0.609 0.592-0.624 OR 1.94 1.21-3.11 1.94 1.21-3.11 2.04 1.47-2.83 2.04 1.47-2.83 2.02 1.63-2.5 2.02 1.63-2.5 1.99 1.69-2.34 1.99 1.69-2.34 1.96 1.73-2.23 1.96 1.73-2.23 1.29 1.06-1.58 0.0112 1.81 1.5-2.18 7.42e-10 2.69 2.24-3.22 4.77e-27 True False False True Female 1341 6444 GRCh37/hg19 s=0.5;Lambda=0.01438 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000516/ScoringFiles/ https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000516/ScoringFiles/ /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE174.1_UKBB-SAIGE-HRC-X174.1_LASSOSUM_MGI_20200608/all.tsv /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE174.1_UKBB-SAIGE-HRC-X174.1_LASSOSUM_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode174-1-icogs-er-negative-brca-lassosum-mgi-20200608 prsweb-phecode174-1-icogs-er-negative-brca-lassosum-mgi-20200608 PRSWEB_PHECODE174.1_iCOGS-ER-negative-BRCA_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE174.1_iCOGS-ER-negative-BRCA_LASSOSUM_MGI_20200608 174.1 Breast cancer [female]; ER negative Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). MGI Michigan Genomics Initiative lassosum Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 270 1.6e-11 0.00610521 0.139 0.546 0.529-0.562 OR 2.11 1.34-3.33 2.11 1.34-3.33 1.82 1.29-2.57 1.82 1.29-2.57 1.56 1.23-1.97 1.56 1.23-1.97 1.61 1.35-1.91 1.61 1.35-1.91 1.51 1.33-1.72 1.51 1.33-1.72 1.15 0.957-1.37 0.137 1.2 1-1.43 0.0479 1.69 1.42-2 1.29e-09 True False False True Female 1341 6444 GRCh37/hg19 s=0.9;Lambda=0.01129 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000523/ScoringFiles/ https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000523/ScoringFiles/ /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE174.1_iCOGS-ER-negative-BRCA_LASSOSUM_MGI_20200608/all.tsv /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE174.1_iCOGS-ER-negative-BRCA_LASSOSUM_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode174-1-icogs-er-positive-brca-lassosum-mgi-20200608 prsweb-phecode174-1-icogs-er-positive-brca-lassosum-mgi-20200608 PRSWEB_PHECODE174.1_iCOGS-ER-positive-BRCA_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE174.1_iCOGS-ER-positive-BRCA_LASSOSUM_MGI_20200608 174.1 Breast cancer [female]; ER positive Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). MGI Michigan Genomics Initiative lassosum Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 98026 2.7e-38 0.0304673 0.136 0.61 0.594-0.626 OR 2.29 1.47-3.59 2.29 1.47-3.59 2.15 1.55-2.98 2.15 1.55-2.98 2.54 2.07-3.12 2.54 2.07-3.12 2.21 1.88-2.59 2.21 1.88-2.59 2.05 1.81-2.32 2.05 1.81-2.32 1.34 1.1-1.62 0.00385 1.6 1.32-1.93 1.43e-06 2.69 2.25-3.21 1.16e-27 True False False True Female 1341 6444 GRCh37/hg19 s=0.9;Lambda=0.008859 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000531/ScoringFiles/ https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000531/ScoringFiles/ /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE174.1_iCOGS-ER-positive-BRCA_LASSOSUM_MGI_20200608/all.tsv /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE174.1_iCOGS-ER-positive-BRCA_LASSOSUM_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode174-1-icogs-overall-brca-lassosum-mgi-20200608 prsweb-phecode174-1-icogs-overall-brca-lassosum-mgi-20200608 PRSWEB_PHECODE174.1_iCOGS-Overall-BRCA_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE174.1_iCOGS-Overall-BRCA_LASSOSUM_MGI_20200608 174.1 Breast cancer [female], Overall Binary You are free to use make use of this resource in publications. If you do so, please cite Michailidou et al (2017) and please acknowledge the following: The breast cancer genome-wide association analyses were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec and grant PSR-SIIRI-701, The National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Michailidou et al (2017). MGI Michigan Genomics Initiative lassosum Michailidou K et al. 2018 29059683 https://www.ncbi.nlm.nih.gov/pubmed/?term=29059683 18356 2.7e-47 0.0336336 0.136 0.624 0.607-0.641 OR 2.49 1.61-3.84 2.49 1.61-3.84 2.8 2.08-3.78 2.8 2.08-3.78 2.61 2.14-3.2 2.61 2.14-3.2 2.22 1.89-2.6 2.22 1.89-2.6 2.14 1.89-2.42 2.14 1.89-2.42 1.54 1.25-1.89 3.62e-05 1.94 1.6-2.37 2.73e-11 3.2 2.66-3.85 1.16e-34 True False False True Female 1341 6444 GRCh37/hg19 s=0.5;Lambda=0.008859 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000539/ScoringFiles/ https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000539/ScoringFiles/ /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE174.1_iCOGS-Overall-BRCA_LASSOSUM_MGI_20200608/all.tsv /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE174.1_iCOGS-Overall-BRCA_LASSOSUM_MGI_20200608/exclusion.tsv 2020-06-08