prs_id slug legacy_id legacy_model prswebprefix trait_code trait_name trait_type description cohort cohort_label method gwas_source reference_label reference_url snp_count p_value pseudo_r2 brier_score mse aauc aauc_ci effect_metric top_effect_1 top_effect_1_ci top_or_1 top_or_1_ci top_effect_2 top_effect_2_ci top_or_2 top_or_2_ci top_effect_5 top_effect_5_ci top_or_5 top_or_5_ci top_effect_10 top_effect_10_ci top_or_10 top_or_10_ci top_effect_25 top_effect_25_ci top_or_25 top_or_25_ci q1_vs_q2_effect q1_vs_q2_effect_ci q1_vs_q2_p_value q1_vs_q3_effect q1_vs_q3_effect_ci q1_vs_q3_p_value q1_vs_q4_effect q1_vs_q4_effect_ci q1_vs_q4_p_value nominally_significant reversed_effect_warning underpowered_warning upload_to_portal sex cases controls genome_build tuning_parameter weights_external_url weights_url phewas_download_url exclusion_download_url last_updated prsweb-phecode191-11-20001-1032-p-5e-05-mgi-20200608 prsweb-phecode191-11-20001-1032-p-5e-05-mgi-20200608 PRSWEB_PHECODE191.11_20001-1032_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE191.11_20001-1032_P_5e-05_MGI_20200608 191.11 Cancer code, self-reported: brain cancer / primary malignant brain tumour Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 47 0.69 4.51008e-05 0.0826 0.509 0.469-0.549 OR 0 0-0 0 0-0 0.924 0.346-2.47 0.924 0.346-2.47 1.05 0.579-1.92 1.05 0.579-1.92 1.24 0.821-1.88 1.24 0.821-1.88 1.14 0.84-1.53 1.14 0.84-1.53 0.967 0.654-1.43 0.866 1.11 0.763-1.63 0.575 1.16 0.794-1.69 0.448 False False False False Both 233 2330 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode191-11-c71-p-5e-05-mgi-20200608 prsweb-phecode191-11-c71-p-5e-05-mgi-20200608 PRSWEB_PHECODE191.11_C71_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE191.11_C71_P_5e-05_MGI_20200608 191.11 Diagnoses - main ICD10: C71 Malignant neoplasm of brain Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 89 0.094 0.000450366 0.0825 0.522 0.481-0.559 OR 2.62 1.08-6.39 2.62 1.08-6.39 1.79 0.845-3.78 1.79 0.845-3.78 1.99 1.24-3.19 1.99 1.24-3.19 1.45 0.975-2.15 1.45 0.975-2.15 1.12 0.827-1.51 1.12 0.827-1.51 1.05 0.713-1.54 0.816 1.06 0.72-1.55 0.782 1.15 0.791-1.68 0.461 False False False False Both 233 2330 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode191-11-gwas-catalog-r2019-05-03-x191-11-p-5e-05-mgi-20200608 prsweb-phecode191-11-gwas-catalog-r2019-05-03-x191-11-p-5e-05-mgi-20200608 PRSWEB_PHECODE191.11_GWAS-Catalog-r2019-05-03-X191.11_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE191.11_GWAS-Catalog-r2019-05-03-X191.11_P_5e-05_MGI_20200608 191.11 Glioblastoma Binary 15 unique SNPs MGI Michigan Genomics Initiative Fixed threshold (5e-05) GWAS Catalog (2019-05-03) 22472174;26424050;28346443 https://www.ncbi.nlm.nih.gov/pubmed/?term=22472174+26424050+28346443 15 0.062 0.002808 0.0825 0.532 0.494-0.57 OR 1.01 0.268-3.8 1.01 0.268-3.8 0.724 0.242-2.17 0.724 0.242-2.17 1.33 0.772-2.31 1.33 0.772-2.31 1.3 0.863-1.95 1.3 0.863-1.95 1.19 0.884-1.61 1.19 0.884-1.61 1.16 0.783-1.73 0.454 1.28 0.864-1.88 0.22 1.36 0.923-2 0.121 False False False False Both 233 2330 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode191-11-ukbb-saige-hrc-x191-11-p-5e-05-mgi-20200608 prsweb-phecode191-11-ukbb-saige-hrc-x191-11-p-5e-05-mgi-20200608 PRSWEB_PHECODE191.11_UKBB-SAIGE-HRC-X191.11_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE191.11_UKBB-SAIGE-HRC-X191.11_P_5e-05_MGI_20200608 191.11 Cancer of brain Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 94 0.39 0.00160506 0.0826 0.513 0.474-0.55 OR 1.01 0.269-3.82 1.01 0.269-3.82 1.58 0.721-3.48 1.58 0.721-3.48 1.06 0.581-1.93 1.06 0.581-1.93 0.948 0.601-1.49 0.948 0.601-1.49 1.09 0.803-1.48 1.09 0.803-1.48 1.4 0.944-2.09 0.0935 1.48 0.995-2.2 0.0528 1.36 0.914-2.03 0.129 False False False False Both 233 2330 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode191-11-20001-1032-p-5e-06-mgi-20200608 prsweb-phecode191-11-20001-1032-p-5e-06-mgi-20200608 PRSWEB_PHECODE191.11_20001-1032_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE191.11_20001-1032_P_5e-06_MGI_20200608 191.11 Cancer code, self-reported: brain cancer / primary malignant brain tumour Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 7 0.79 7.02745e-05 0.0826 0.503 0.461-0.542 OR 0.978 0.258-3.7 0.978 0.258-3.7 1.12 0.454-2.76 1.12 0.454-2.76 0.955 0.512-1.78 0.955 0.512-1.78 1.04 0.67-1.61 1.04 0.67-1.61 1.11 0.818-1.5 1.11 0.818-1.5 1.14 0.772-1.68 0.511 1.14 0.771-1.67 0.52 1.2 0.816-1.76 0.358 False False False False Both 233 2330 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode191-11-c3-brain-p-5e-06-mgi-20200608 prsweb-phecode191-11-c3-brain-p-5e-06-mgi-20200608 PRSWEB_PHECODE191.11_C3-BRAIN_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE191.11_C3-BRAIN_P_5e-06_MGI_20200608 191.11 Malignant neoplasm of brain Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 16 0.82 0.000111995 0.0826 0.498 0.461-0.536 OR 0 0-0 0 0-0 0.102 0.00624-1.67 0.102 0.00624-1.67 0.703 0.346-1.43 0.703 0.346-1.43 0.861 0.537-1.38 0.861 0.537-1.38 0.997 0.732-1.36 0.997 0.732-1.36 1 0.686-1.47 0.984 1.06 0.725-1.54 0.772 1.01 0.692-1.48 0.952 False False False False Both 233 2330 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode191-11-c71-p-5e-06-mgi-20200608 prsweb-phecode191-11-c71-p-5e-06-mgi-20200608 PRSWEB_PHECODE191.11_C71_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE191.11_C71_P_5e-06_MGI_20200608 191.11 Diagnoses - main ICD10: C71 Malignant neoplasm of brain Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 15 0.0097 0.00131584 0.0824 0.541 0.5-0.582 OR 3.56 1.59-7.96 3.56 1.59-7.96 2.05 1-4.19 2.05 1-4.19 1.15 0.643-2.05 1.15 0.643-2.05 1.88 1.3-2.7 1.88 1.3-2.7 1.27 0.944-1.7 1.27 0.944-1.7 1.22 0.817-1.81 0.334 1.27 0.859-1.89 0.23 1.5 1.02-2.2 0.0394 True False False False Both 233 2330 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode191-11-gwas-catalog-r2019-05-03-x191-11-p-5e-06-mgi-20200608 prsweb-phecode191-11-gwas-catalog-r2019-05-03-x191-11-p-5e-06-mgi-20200608 PRSWEB_PHECODE191.11_GWAS-Catalog-r2019-05-03-X191.11_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE191.11_GWAS-Catalog-r2019-05-03-X191.11_P_5e-06_MGI_20200608 191.11 Glioblastoma Binary 15 unique SNPs MGI Michigan Genomics Initiative Fixed threshold (5e-06) GWAS Catalog (2019-05-03) 22472174;26424050;28346443 https://www.ncbi.nlm.nih.gov/pubmed/?term=22472174+26424050+28346443 14 0.062 0.00340651 0.0825 0.532 0.494-0.57 OR 0.599 0.112-3.2 0.599 0.112-3.2 0.515 0.143-1.86 0.515 0.143-1.86 1.52 0.903-2.56 1.52 0.903-2.56 1.25 0.824-1.89 1.25 0.824-1.89 1.19 0.884-1.61 1.19 0.884-1.61 1.19 0.796-1.77 0.401 1.32 0.891-1.95 0.168 1.4 0.949-2.06 0.09 False False False False Both 233 2330 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode191-11-ukbb-saige-hrc-x191-11-p-5e-06-mgi-20200608 prsweb-phecode191-11-ukbb-saige-hrc-x191-11-p-5e-06-mgi-20200608 PRSWEB_PHECODE191.11_UKBB-SAIGE-HRC-X191.11_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE191.11_UKBB-SAIGE-HRC-X191.11_P_5e-06_MGI_20200608 191.11 Cancer of brain Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 14 0.016 0.00337569 0.0824 0.534 0.495-0.574 OR 1.41 0.45-4.44 1.41 0.45-4.44 1.81 0.857-3.82 1.81 0.857-3.82 1.33 0.771-2.3 1.33 0.771-2.3 1.09 0.711-1.69 1.09 0.711-1.69 1.43 1.07-1.91 1.43 1.07-1.91 0.837 0.559-1.25 0.386 1.02 0.694-1.49 0.926 1.36 0.947-1.96 0.0961 True False False False Both 233 2330 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode191-11-c3-brain-p-5e-07-mgi-20200608 prsweb-phecode191-11-c3-brain-p-5e-07-mgi-20200608 PRSWEB_PHECODE191.11_C3-BRAIN_P_5e-07_MGI_20200608 P_5e-07 PRSWEB_PHECODE191.11_C3-BRAIN_P_5e-07_MGI_20200608 191.11 Malignant neoplasm of brain Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-07) UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 6 0.084 0.000256754 0.0825 0.534 0.497-0.572 OR 1.01 0.268-3.82 1.01 0.268-3.82 0.721 0.24-2.16 0.721 0.24-2.16 0.707 0.348-1.44 0.707 0.348-1.44 0.903 0.568-1.44 0.903 0.568-1.44 1.34 1-1.8 1.34 1-1.8 1.29 0.869-1.92 0.204 1.21 0.81-1.81 0.351 1.56 1.06-2.29 0.0233 False False False False Both 233 2330 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode191-11-gwas-catalog-r2019-05-03-x191-11-p-5e-07-mgi-20200608 prsweb-phecode191-11-gwas-catalog-r2019-05-03-x191-11-p-5e-07-mgi-20200608 PRSWEB_PHECODE191.11_GWAS-Catalog-r2019-05-03-X191.11_P_5e-07_MGI_20200608 P_5e-07 PRSWEB_PHECODE191.11_GWAS-Catalog-r2019-05-03-X191.11_P_5e-07_MGI_20200608 191.11 Glioblastoma Binary 15 unique SNPs MGI Michigan Genomics Initiative Fixed threshold (5e-07) GWAS Catalog (2019-05-03) 22472174;26424050;28346443 https://www.ncbi.nlm.nih.gov/pubmed/?term=22472174+26424050+28346443 12 0.03 0.00340919 0.0825 0.54 0.503-0.579 OR 1.02 0.271-3.86 1.02 0.271-3.86 1.36 0.59-3.14 1.36 0.59-3.14 1.34 0.773-2.31 1.34 0.773-2.31 1.5 1.02-2.22 1.5 1.02-2.22 1.14 0.845-1.54 1.14 0.845-1.54 0.965 0.639-1.46 0.865 1.49 1.02-2.17 0.0382 1.28 0.87-1.88 0.209 True False False False Both 233 2330 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode191-11-gwas-catalog-r2019-05-03-x191-11-p-5e-09-mgi-20200608 prsweb-phecode191-11-gwas-catalog-r2019-05-03-x191-11-p-5e-09-mgi-20200608 PRSWEB_PHECODE191.11_GWAS-Catalog-r2019-05-03-X191.11_P_5e-09_MGI_20200608 P_5e-09 PRSWEB_PHECODE191.11_GWAS-Catalog-r2019-05-03-X191.11_P_5e-09_MGI_20200608 191.11 Glioblastoma Binary 15 unique SNPs MGI Michigan Genomics Initiative Fixed threshold (5e-09) GWAS Catalog (2019-05-03) 22472174;26424050;28346443 https://www.ncbi.nlm.nih.gov/pubmed/?term=22472174+26424050+28346443 11 0.035 0.00344775 0.0825 0.538 0.501-0.577 OR 0.602 0.113-3.22 0.602 0.113-3.22 0.935 0.351-2.49 0.935 0.351-2.49 1.24 0.707-2.18 1.24 0.707-2.18 1.3 0.862-1.95 1.3 0.862-1.95 1.29 0.964-1.73 1.29 0.964-1.73 0.957 0.639-1.43 0.833 1.24 0.848-1.82 0.266 1.34 0.918-1.95 0.131 True False False False Both 233 2330 GRCh37/hg19 P<=5e-09 2020-06-08 prsweb-phecode191-11-gwas-catalog-r2019-05-03-x191-11-p-5e-08-mgi-20200608 prsweb-phecode191-11-gwas-catalog-r2019-05-03-x191-11-p-5e-08-mgi-20200608 PRSWEB_PHECODE191.11_GWAS-Catalog-r2019-05-03-X191.11_P_5e-08_MGI_20200608 P_5e-08 PRSWEB_PHECODE191.11_GWAS-Catalog-r2019-05-03-X191.11_P_5e-08_MGI_20200608 191.11 Glioblastoma Binary 15 unique SNPs MGI Michigan Genomics Initiative GWAS Hits GWAS Catalog (2019-05-03) 22472174;26424050;28346443 https://www.ncbi.nlm.nih.gov/pubmed/?term=22472174+26424050+28346443 12 0.03 0.00340919 0.0825 0.54 0.503-0.579 OR 1.02 0.271-3.86 1.02 0.271-3.86 1.36 0.59-3.14 1.36 0.59-3.14 1.34 0.773-2.31 1.34 0.773-2.31 1.5 1.02-2.22 1.5 1.02-2.22 1.14 0.845-1.54 1.14 0.845-1.54 0.965 0.639-1.46 0.865 1.49 1.02-2.17 0.0382 1.28 0.87-1.88 0.209 True False False True Both 233 2330 GRCh37/hg19 P<=5e-08 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000621/ScoringFiles/ https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000621/ScoringFiles/ /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE191.11_GWAS-Catalog-r2019-05-03-X191.11_P_5e-08_MGI_20200608/all.tsv /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE191.11_GWAS-Catalog-r2019-05-03-X191.11_P_5e-08_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode191-11-20001-1032-pt-mgi-20200608 prsweb-phecode191-11-20001-1032-pt-mgi-20200608 PRSWEB_PHECODE191.11_20001-1032_PT_MGI_20200608 P&T PRSWEB_PHECODE191.11_20001-1032_PT_MGI_20200608 191.11 Cancer code, self-reported: brain cancer / primary malignant brain tumour Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative P&T UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 82 0.46 0.000524096 0.0826 0.512 0.473-0.55 OR 0.603 0.113-3.22 0.603 0.113-3.22 1.58 0.72-3.47 1.58 0.72-3.47 1.51 0.899-2.55 1.51 0.899-2.55 1.14 0.746-1.75 1.14 0.746-1.75 1.21 0.9-1.63 1.21 0.9-1.63 0.941 0.639-1.39 0.76 0.968 0.66-1.42 0.867 1.18 0.818-1.71 0.374 False False False False Both 233 2330 GRCh37/hg19 P<=7.94e-05 2020-06-08 prsweb-phecode191-11-c71-pt-mgi-20200608 prsweb-phecode191-11-c71-pt-mgi-20200608 PRSWEB_PHECODE191.11_C71_PT_MGI_20200608 P&T PRSWEB_PHECODE191.11_C71_PT_MGI_20200608 191.11 Diagnoses - main ICD10: C71 Malignant neoplasm of brain Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative P&T UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 29 0.12 0.00332215 0.0825 0.528 0.486-0.571 OR 2.26 0.875-5.84 2.26 0.875-5.84 1.8 0.852-3.81 1.8 0.852-3.81 0.971 0.521-1.81 0.971 0.521-1.81 1.05 0.677-1.63 1.05 0.677-1.63 1.22 0.903-1.64 1.22 0.903-1.64 0.788 0.525-1.18 0.252 1.16 0.801-1.68 0.429 1.2 0.827-1.74 0.34 False False False False Both 233 2330 GRCh37/hg19 P<=1.26e-05 2020-06-08 prsweb-phecode191-11-gwas-catalog-r2019-05-03-x191-11-pt-mgi-20200608 prsweb-phecode191-11-gwas-catalog-r2019-05-03-x191-11-pt-mgi-20200608 PRSWEB_PHECODE191.11_GWAS-Catalog-r2019-05-03-X191.11_PT_MGI_20200608 P&T PRSWEB_PHECODE191.11_GWAS-Catalog-r2019-05-03-X191.11_PT_MGI_20200608 191.11 Glioblastoma Binary 15 unique SNPs MGI Michigan Genomics Initiative P&T GWAS Catalog (2019-05-03) 22472174;26424050;28346443 https://www.ncbi.nlm.nih.gov/pubmed/?term=22472174+26424050+28346443 11 0.035 0.00344775 0.0825 0.538 0.501-0.577 OR 0.602 0.113-3.22 0.602 0.113-3.22 0.935 0.351-2.49 0.935 0.351-2.49 1.24 0.707-2.18 1.24 0.707-2.18 1.3 0.862-1.95 1.3 0.862-1.95 1.29 0.964-1.73 1.29 0.964-1.73 0.957 0.639-1.43 0.833 1.24 0.848-1.82 0.266 1.34 0.918-1.95 0.131 True False False True Both 233 2330 GRCh37/hg19 P<=3.16e-09 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000623/ScoringFiles/ https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000623/ScoringFiles/ /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE191.11_GWAS-Catalog-r2019-05-03-X191.11_PT_MGI_20200608/all.tsv /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE191.11_GWAS-Catalog-r2019-05-03-X191.11_PT_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode191-11-ukbb-saige-hrc-x191-11-pt-mgi-20200608 prsweb-phecode191-11-ukbb-saige-hrc-x191-11-pt-mgi-20200608 PRSWEB_PHECODE191.11_UKBB-SAIGE-HRC-X191.11_PT_MGI_20200608 P&T PRSWEB_PHECODE191.11_UKBB-SAIGE-HRC-X191.11_PT_MGI_20200608 191.11 Cancer of brain Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative P&T UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 11 0.043 0.00566359 0.0825 0.53 0.492-0.57 OR 2.28 0.88-5.88 2.28 0.88-5.88 1.81 0.855-3.81 1.81 0.855-3.81 1.34 0.773-2.31 1.34 0.773-2.31 1.05 0.676-1.63 1.05 0.676-1.63 1.3 0.966-1.74 1.3 0.966-1.74 0.91 0.604-1.37 0.651 1.27 0.87-1.86 0.215 1.37 0.944-2 0.0971 True False False True Both 233 2330 GRCh37/hg19 P<=2.51e-06 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000625/ScoringFiles/ https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000625/ScoringFiles/ /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE191.11_UKBB-SAIGE-HRC-X191.11_PT_MGI_20200608/all.tsv /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE191.11_UKBB-SAIGE-HRC-X191.11_PT_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode191-11-c3-brain-prs-cs-mgi-20200608 prsweb-phecode191-11-c3-brain-prs-cs-mgi-20200608 PRSWEB_PHECODE191.11_C3-BRAIN_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE191.11_C3-BRAIN_PRS-CS_MGI_20200608 191.11 Malignant neoplasm of brain Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative PRS-CS UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1050964 0.39 0.000407059 0.0826 0.508 0.471-0.549 OR 1.43 0.454-4.49 1.43 0.454-4.49 1.59 0.724-3.5 1.59 0.724-3.5 1.43 0.838-2.44 1.43 0.838-2.44 1.35 0.9-2.02 1.35 0.9-2.02 0.954 0.698-1.3 0.954 0.698-1.3 0.882 0.601-1.29 0.521 1.06 0.734-1.53 0.76 0.936 0.642-1.37 0.732 False False False False Both 233 2330 GRCh37/hg19 auto 2020-06-08 prsweb-phecode191-11-c71-prs-cs-mgi-20200608 prsweb-phecode191-11-c71-prs-cs-mgi-20200608 PRSWEB_PHECODE191.11_C71_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE191.11_C71_PRS-CS_MGI_20200608 191.11 Diagnoses - main ICD10: C71 Malignant neoplasm of brain Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative PRS-CS UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1055124 0.49 0.00021369 0.0826 0.514 0.476-0.556 OR 0.607 0.113-3.25 0.607 0.113-3.25 1.16 0.473-2.85 1.16 0.473-2.85 0.981 0.527-1.83 0.981 0.527-1.83 1.05 0.68-1.64 1.05 0.68-1.64 1.02 0.751-1.39 1.02 0.751-1.39 1.34 0.911-1.98 0.137 1.21 0.823-1.79 0.329 1.17 0.791-1.74 0.43 False False False False Both 233 2330 GRCh37/hg19 auto 2020-06-08 prsweb-phecode191-11-ukbb-saige-hrc-x191-11-prs-cs-mgi-20200608 prsweb-phecode191-11-ukbb-saige-hrc-x191-11-prs-cs-mgi-20200608 PRSWEB_PHECODE191.11_UKBB-SAIGE-HRC-X191.11_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE191.11_UKBB-SAIGE-HRC-X191.11_PRS-CS_MGI_20200608 191.11 Cancer of brain Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative PRS-CS UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1119238 0.11 0.000581856 0.0825 0.527 0.487-0.567 OR 1.04 0.274-3.91 1.04 0.274-3.91 1.39 0.603-3.21 1.39 0.603-3.21 1.25 0.71-2.19 1.25 0.71-2.19 1.15 0.749-1.75 1.15 0.749-1.75 1.15 0.848-1.55 1.15 0.848-1.55 1.52 1.02-2.26 0.0387 1.38 0.924-2.07 0.115 1.5 1.01-2.24 0.0458 False False False False Both 233 2330 GRCh37/hg19 auto 2020-06-08 prsweb-phecode191-11-20001-1032-lassosum-mgi-20200608 prsweb-phecode191-11-20001-1032-lassosum-mgi-20200608 PRSWEB_PHECODE191.11_20001-1032_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE191.11_20001-1032_LASSOSUM_MGI_20200608 191.11 Cancer code, self-reported: brain cancer / primary malignant brain tumour Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative lassosum UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 24094 0.6 0.00233931 0.0826 0.509 0.474-0.55 OR 3.13 1.35-7.28 3.13 1.35-7.28 1.83 0.865-3.86 1.83 0.865-3.86 1.07 0.585-1.94 1.07 0.585-1.94 1.1 0.716-1.7 1.1 0.716-1.7 1.05 0.771-1.43 1.05 0.771-1.43 0.719 0.486-1.06 0.0993 1.01 0.699-1.45 0.972 0.912 0.629-1.32 0.627 False False False False Both 233 2330 GRCh37/hg19 s=0.2;Lambda=0.07848 2020-06-08 prsweb-phecode191-11-c3-brain-lassosum-mgi-20200608 prsweb-phecode191-11-c3-brain-lassosum-mgi-20200608 PRSWEB_PHECODE191.11_C3-BRAIN_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE191.11_C3-BRAIN_LASSOSUM_MGI_20200608 191.11 Malignant neoplasm of brain Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative lassosum UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 3656328 0.49 0.000529995 0.0826 0.51 0.473-0.545 OR 1.84 0.658-5.17 1.84 0.658-5.17 1.15 0.469-2.83 1.15 0.469-2.83 0.883 0.463-1.69 0.883 0.463-1.69 0.863 0.538-1.38 0.863 0.538-1.38 0.845 0.612-1.17 0.845 0.612-1.17 1.32 0.887-1.95 0.173 1.6 1.09-2.34 0.0158 1.12 0.744-1.69 0.584 False False False False Both 233 2330 GRCh37/hg19 s=0.9;Lambda=0.002069 2020-06-08 prsweb-phecode191-11-c71-lassosum-mgi-20200608 prsweb-phecode191-11-c71-lassosum-mgi-20200608 PRSWEB_PHECODE191.11_C71_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE191.11_C71_LASSOSUM_MGI_20200608 191.11 Diagnoses - main ICD10: C71 Malignant neoplasm of brain Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative lassosum UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 522 0.0092 0.00158244 0.0824 0.546 0.504-0.587 OR 1.42 0.453-4.47 1.42 0.453-4.47 1.37 0.595-3.17 1.37 0.595-3.17 1.07 0.587-1.95 1.07 0.587-1.95 1.56 1.06-2.29 1.56 1.06-2.29 1.46 1.09-1.94 1.46 1.09-1.94 1.23 0.824-1.83 0.313 1.18 0.79-1.77 0.414 1.65 1.13-2.41 0.0102 True False False True Both 233 2330 GRCh37/hg19 s=0.9;Lambda=0.1 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000620/ScoringFiles/ https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000620/ScoringFiles/ /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE191.11_C71_LASSOSUM_MGI_20200608/all.tsv /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE191.11_C71_LASSOSUM_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode191-11-ukbb-saige-hrc-x191-11-lassosum-mgi-20200608 prsweb-phecode191-11-ukbb-saige-hrc-x191-11-lassosum-mgi-20200608 PRSWEB_PHECODE191.11_UKBB-SAIGE-HRC-X191.11_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE191.11_UKBB-SAIGE-HRC-X191.11_LASSOSUM_MGI_20200608 191.11 Cancer of brain Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative lassosum UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1621 0.12 0.00312641 0.0826 0.538 0.501-0.576 OR 1.01 0.268-3.82 1.01 0.268-3.82 0.516 0.143-1.87 0.516 0.143-1.87 0.799 0.407-1.57 0.799 0.407-1.57 0.911 0.573-1.45 0.911 0.573-1.45 1.3 0.966-1.74 1.3 0.966-1.74 1.35 0.907-2.01 0.138 1.29 0.861-1.93 0.217 1.55 1.05-2.3 0.0281 False False False False Both 233 2330 GRCh37/hg19 s=0.5;Lambda=0.07848 2020-06-08