prs_id slug legacy_id legacy_model prswebprefix trait_code trait_name trait_type description cohort cohort_label method gwas_source reference_label reference_url snp_count p_value pseudo_r2 brier_score mse aauc aauc_ci effect_metric top_effect_1 top_effect_1_ci top_or_1 top_or_1_ci top_effect_2 top_effect_2_ci top_or_2 top_or_2_ci top_effect_5 top_effect_5_ci top_or_5 top_or_5_ci top_effect_10 top_effect_10_ci top_or_10 top_or_10_ci top_effect_25 top_effect_25_ci top_or_25 top_or_25_ci q1_vs_q2_effect q1_vs_q2_effect_ci q1_vs_q2_p_value q1_vs_q3_effect q1_vs_q3_effect_ci q1_vs_q3_p_value q1_vs_q4_effect q1_vs_q4_effect_ci q1_vs_q4_p_value nominally_significant reversed_effect_warning underpowered_warning upload_to_portal sex cases controls genome_build tuning_parameter weights_external_url weights_url phewas_download_url exclusion_download_url last_updated prsweb-phecode204-4-c-multiple-myeloma-plasma-cell-p-5e-05-mgi-20200608 prsweb-phecode204-4-c-multiple-myeloma-plasma-cell-p-5e-05-mgi-20200608 PRSWEB_PHECODE204.4_C-MULTIPLE-MYELOMA-PLASMA-CELL_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE204.4_C-MULTIPLE-MYELOMA-PLASMA-CELL_P_5e-05_MGI_20200608 204.4 Multiple myeloma and malignant plasma cell neoplasms Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 85 0.11 0.0002392 0.0825 0.548 0.481-0.609 OR 0 0-0 0 0-0 0.802 0.143-4.49 0.802 0.143-4.49 1.03 0.376-2.83 1.03 0.376-2.83 1.74 0.93-3.26 1.74 0.93-3.26 1.52 0.946-2.46 1.52 0.946-2.46 1.44 0.744-2.8 0.277 0.889 0.439-1.8 0.744 1.74 0.927-3.26 0.0846 False False False False Both 83 825 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode204-4-c90-p-5e-05-mgi-20200608 prsweb-phecode204-4-c90-p-5e-05-mgi-20200608 PRSWEB_PHECODE204.4_C90_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE204.4_C90_P_5e-05_MGI_20200608 204.4 Diagnoses - main ICD10: C90 Multiple myeloma and malignant plasma cell neoplasms Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-05) UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 107 0.21 0.000125465 0.0826 0.535 0.475-0.598 OR 2.69 0.615-11.7 2.69 0.615-11.7 1.51 0.381-5.97 1.51 0.381-5.97 1.63 0.686-3.85 1.63 0.686-3.85 1.18 0.581-2.41 1.18 0.581-2.41 1.17 0.707-1.92 1.17 0.707-1.92 1.39 0.714-2.7 0.334 1.52 0.786-2.94 0.214 1.49 0.765-2.91 0.241 False False False False Both 83 825 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode204-4-gwas-catalog-r2019-05-03-x204-4-p-5e-05-mgi-20200608 prsweb-phecode204-4-gwas-catalog-r2019-05-03-x204-4-p-5e-05-mgi-20200608 PRSWEB_PHECODE204.4_GWAS-Catalog-r2019-05-03-X204.4_P_5e-05_MGI_20200608 P_5e-05 PRSWEB_PHECODE204.4_GWAS-Catalog-r2019-05-03-X204.4_P_5e-05_MGI_20200608 204.4 Multiple myeloma (hyperdiploidy);Multiple myeloma (IgH translocation);Multiple myeloma;Multiple myeloma and monoclonal gammopathy Binary 70 unique SNPs MGI Michigan Genomics Initiative Fixed threshold (5e-05) GWAS Catalog (2019-05-03) 22120009;23502783;23955597;26007630;27363682;30213928 https://www.ncbi.nlm.nih.gov/pubmed/?term=22120009+23502783+23955597+26007630+27363682+30213928 54 0.54 0.0108481 0.0827 0.509 0.436-0.58 OR 1.23 0.194-7.84 1.23 0.194-7.84 2.27 0.753-6.85 2.27 0.753-6.85 1.96 0.894-4.28 1.96 0.894-4.28 1.5 0.787-2.85 1.5 0.787-2.85 1.27 0.776-2.08 1.27 0.776-2.08 0.358 0.172-0.743 0.00581 0.75 0.414-1.36 0.342 0.883 0.496-1.57 0.671 False False False False Both 83 825 GRCh37/hg19 P<=5e-05 2020-06-08 prsweb-phecode204-4-20001-1050-p-5e-06-mgi-20200608 prsweb-phecode204-4-20001-1050-p-5e-06-mgi-20200608 PRSWEB_PHECODE204.4_20001-1050_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE204.4_20001-1050_P_5e-06_MGI_20200608 204.4 Cancer code, self-reported: multiple myeloma Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 5 0.099 0.00511081 0.0824 0.539 0.467-0.61 OR 2.28 0.515-10.1 2.28 0.515-10.1 1.33 0.335-5.26 1.33 0.335-5.26 1.49 0.627-3.53 1.49 0.627-3.53 1.33 0.679-2.59 1.33 0.679-2.59 1.27 0.776-2.06 1.27 0.776-2.06 0.744 0.37-1.49 0.405 1.23 0.667-2.28 0.502 1.28 0.688-2.37 0.438 False False False False Both 83 825 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode204-4-c-multiple-myeloma-plasma-cell-p-5e-06-mgi-20200608 prsweb-phecode204-4-c-multiple-myeloma-plasma-cell-p-5e-06-mgi-20200608 PRSWEB_PHECODE204.4_C-MULTIPLE-MYELOMA-PLASMA-CELL_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE204.4_C-MULTIPLE-MYELOMA-PLASMA-CELL_P_5e-06_MGI_20200608 204.4 Multiple myeloma and malignant plasma cell neoplasms Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 11 0.028 0.000659298 0.0822 0.559 0.498-0.617 OR 2.61 0.598-11.4 2.61 0.598-11.4 1.42 0.359-5.6 1.42 0.359-5.6 1.34 0.533-3.39 1.34 0.533-3.39 1.43 0.736-2.78 1.43 0.736-2.78 1.54 0.954-2.47 1.54 0.954-2.47 0.792 0.385-1.63 0.525 1.41 0.748-2.65 0.289 1.6 0.865-2.95 0.134 True False False False Both 83 825 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode204-4-c90-p-5e-06-mgi-20200608 prsweb-phecode204-4-c90-p-5e-06-mgi-20200608 PRSWEB_PHECODE204.4_C90_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE204.4_C90_P_5e-06_MGI_20200608 204.4 Diagnoses - main ICD10: C90 Multiple myeloma and malignant plasma cell neoplasms Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 19 0.17 0.000368938 0.0826 0.534 0.469-0.598 OR 1.52 0.247-9.34 1.52 0.247-9.34 1.4 0.356-5.53 1.4 0.356-5.53 1.3 0.518-3.27 1.3 0.518-3.27 1.39 0.718-2.69 1.39 0.718-2.69 1.35 0.835-2.2 1.35 0.835-2.2 0.84 0.416-1.7 0.628 1.39 0.747-2.6 0.298 1.47 0.792-2.73 0.222 False False False False Both 83 825 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode204-4-gwas-catalog-r2019-05-03-x204-4-p-5e-06-mgi-20200608 prsweb-phecode204-4-gwas-catalog-r2019-05-03-x204-4-p-5e-06-mgi-20200608 PRSWEB_PHECODE204.4_GWAS-Catalog-r2019-05-03-X204.4_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE204.4_GWAS-Catalog-r2019-05-03-X204.4_P_5e-06_MGI_20200608 204.4 Multiple myeloma (hyperdiploidy);Multiple myeloma (IgH translocation);Multiple myeloma;Multiple myeloma and monoclonal gammopathy Binary 70 unique SNPs MGI Michigan Genomics Initiative Fixed threshold (5e-06) GWAS Catalog (2019-05-03) 22120009;23502783;23955597;26007630;27363682;30213928 https://www.ncbi.nlm.nih.gov/pubmed/?term=22120009+23502783+23955597+26007630+27363682+30213928 45 0.51 0.0241372 0.0827 0.516 0.443-0.583 OR 0 0-0 0 0-0 0.232 0.0135-4 0.232 0.0135-4 1.2 0.474-3.02 1.2 0.474-3.02 1.45 0.757-2.77 1.45 0.757-2.77 1.35 0.83-2.18 1.35 0.83-2.18 0.568 0.29-1.11 0.099 0.778 0.419-1.44 0.425 1.09 0.612-1.95 0.764 False False False False Both 83 825 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode204-4-ukbb-saige-hrc-x204-4-p-5e-06-mgi-20200608 prsweb-phecode204-4-ukbb-saige-hrc-x204-4-p-5e-06-mgi-20200608 PRSWEB_PHECODE204.4_UKBB-SAIGE-HRC-X204.4_P_5e-06_MGI_20200608 P_5e-06 PRSWEB_PHECODE204.4_UKBB-SAIGE-HRC-X204.4_P_5e-06_MGI_20200608 204.4 Multiple myeloma Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative Fixed threshold (5e-06) UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 10 0.81 0.00459676 0.0827 0.499 0.439-0.56 OR 0 0-0 0 0-0 0.278 0.016-4.85 0.278 0.016-4.85 0.785 0.257-2.39 0.785 0.257-2.39 0.635 0.261-1.54 0.635 0.261-1.54 1.03 0.616-1.73 1.03 0.616-1.73 0.793 0.414-1.52 0.483 1.19 0.646-2.18 0.583 0.977 0.521-1.83 0.943 False False False False Both 83 825 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode204-4-gwas-catalog-r2019-05-03-x204-4-p-5e-07-mgi-20200608 prsweb-phecode204-4-gwas-catalog-r2019-05-03-x204-4-p-5e-07-mgi-20200608 PRSWEB_PHECODE204.4_GWAS-Catalog-r2019-05-03-X204.4_P_5e-07_MGI_20200608 P_5e-07 PRSWEB_PHECODE204.4_GWAS-Catalog-r2019-05-03-X204.4_P_5e-07_MGI_20200608 204.4 Multiple myeloma (hyperdiploidy);Multiple myeloma (IgH translocation);Multiple myeloma;Multiple myeloma and monoclonal gammopathy Binary 70 unique SNPs MGI Michigan Genomics Initiative Fixed threshold (5e-07) GWAS Catalog (2019-05-03) 22120009;23502783;23955597;26007630;27363682;30213928 https://www.ncbi.nlm.nih.gov/pubmed/?term=22120009+23502783+23955597+26007630+27363682+30213928 28 0.28 0.0135146 0.0826 0.519 0.453-0.583 OR 3.79 1.01-14.2 3.79 1.01-14.2 2.69 0.892-8.13 2.69 0.892-8.13 2.09 0.949-4.59 2.09 0.949-4.59 1.5 0.789-2.86 1.5 0.789-2.86 1.39 0.853-2.25 1.39 0.853-2.25 1.05 0.569-1.95 0.869 0.665 0.336-1.31 0.241 1.27 0.696-2.31 0.44 False False False False Both 83 825 GRCh37/hg19 P<=5e-07 2020-06-08 prsweb-phecode204-4-gwas-catalog-r2019-05-03-x204-4-p-5e-09-mgi-20200608 prsweb-phecode204-4-gwas-catalog-r2019-05-03-x204-4-p-5e-09-mgi-20200608 PRSWEB_PHECODE204.4_GWAS-Catalog-r2019-05-03-X204.4_P_5e-09_MGI_20200608 P_5e-09 PRSWEB_PHECODE204.4_GWAS-Catalog-r2019-05-03-X204.4_P_5e-09_MGI_20200608 204.4 Multiple myeloma (hyperdiploidy);Multiple myeloma (IgH translocation);Multiple myeloma;Multiple myeloma and monoclonal gammopathy Binary 70 unique SNPs MGI Michigan Genomics Initiative Fixed threshold (5e-09) GWAS Catalog (2019-05-03) 22120009;23502783;23955597;26007630;27363682;30213928 https://www.ncbi.nlm.nih.gov/pubmed/?term=22120009+23502783+23955597+26007630+27363682+30213928 15 0.31 0.0059964 0.0826 0.524 0.46-0.584 OR 3.7 1-13.6 3.7 1-13.6 3.25 1.17-9.02 3.25 1.17-9.02 1.25 0.496-3.15 1.25 0.496-3.15 0.857 0.392-1.87 0.857 0.392-1.87 1.26 0.766-2.06 1.26 0.766-2.06 1.49 0.792-2.81 0.215 0.972 0.492-1.92 0.935 1.45 0.763-2.74 0.258 False False False False Both 83 825 GRCh37/hg19 P<=5e-09 2020-06-08 prsweb-phecode204-4-gwas-catalog-r2019-05-03-x204-4-p-5e-08-mgi-20200608 prsweb-phecode204-4-gwas-catalog-r2019-05-03-x204-4-p-5e-08-mgi-20200608 PRSWEB_PHECODE204.4_GWAS-Catalog-r2019-05-03-X204.4_P_5e-08_MGI_20200608 P_5e-08 PRSWEB_PHECODE204.4_GWAS-Catalog-r2019-05-03-X204.4_P_5e-08_MGI_20200608 204.4 Multiple myeloma (hyperdiploidy);Multiple myeloma (IgH translocation);Multiple myeloma;Multiple myeloma and monoclonal gammopathy Binary 70 unique SNPs MGI Michigan Genomics Initiative GWAS Hits GWAS Catalog (2019-05-03) 22120009;23502783;23955597;26007630;27363682;30213928 https://www.ncbi.nlm.nih.gov/pubmed/?term=22120009+23502783+23955597+26007630+27363682+30213928 22 0.15 0.00813378 0.0826 0.536 0.473-0.598 OR 4.92 1.48-16.4 4.92 1.48-16.4 3.32 1.2-9.21 3.32 1.2-9.21 1.75 0.768-3.97 1.75 0.768-3.97 1.28 0.645-2.54 1.28 0.645-2.54 1.17 0.709-1.92 1.17 0.709-1.92 1.4 0.718-2.74 0.323 1.65 0.848-3.21 0.141 1.62 0.835-3.14 0.154 False False False False Both 83 825 GRCh37/hg19 P<=5e-08 2020-06-08 prsweb-phecode204-4-c-multiple-myeloma-plasma-cell-pt-mgi-20200608 prsweb-phecode204-4-c-multiple-myeloma-plasma-cell-pt-mgi-20200608 PRSWEB_PHECODE204.4_C-MULTIPLE-MYELOMA-PLASMA-CELL_PT_MGI_20200608 P&T PRSWEB_PHECODE204.4_C-MULTIPLE-MYELOMA-PLASMA-CELL_PT_MGI_20200608 204.4 Multiple myeloma and malignant plasma cell neoplasms Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative P&T UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 32 0.24 0.00188238 0.0826 0.523 0.461-0.587 OR 0 0-0 0 0-0 2.07 0.626-6.82 2.07 0.626-6.82 1.83 0.81-4.14 1.83 0.81-4.14 1.41 0.724-2.73 1.41 0.724-2.73 1.09 0.661-1.81 1.09 0.661-1.81 1.11 0.579-2.12 0.758 1.27 0.671-2.4 0.464 1.18 0.629-2.22 0.604 False False False False Both 83 825 GRCh37/hg19 P<=1.58e-05 2020-06-08 prsweb-phecode204-4-c90-pt-mgi-20200608 prsweb-phecode204-4-c90-pt-mgi-20200608 PRSWEB_PHECODE204.4_C90_PT_MGI_20200608 P&T PRSWEB_PHECODE204.4_C90_PT_MGI_20200608 204.4 Diagnoses - main ICD10: C90 Multiple myeloma and malignant plasma cell neoplasms Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative P&T UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 27 0.044 0.0013006 0.0823 0.547 0.479-0.613 OR 2.6 0.593-11.4 2.6 0.593-11.4 1.95 0.588-6.45 1.95 0.588-6.45 1.49 0.631-3.53 1.49 0.631-3.53 1.52 0.8-2.88 1.52 0.8-2.88 1.77 1.11-2.83 1.77 1.11-2.83 1.16 0.593-2.26 0.668 0.965 0.487-1.91 0.919 1.83 0.996-3.37 0.0516 True False False True Both 83 825 GRCh37/hg19 P<=7.94e-06 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000652/ScoringFiles/ https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000652/ScoringFiles/ /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE204.4_C90_PT_MGI_20200608/all.tsv /larsf/prsweb-data/cancerprsweb/releases/cancerprsweb_20200608/phewas/PRSWEB_PHECODE204.4_C90_PT_MGI_20200608/exclusion.tsv 2020-06-08 prsweb-phecode204-4-gwas-catalog-r2019-05-03-x204-4-pt-mgi-20200608 prsweb-phecode204-4-gwas-catalog-r2019-05-03-x204-4-pt-mgi-20200608 PRSWEB_PHECODE204.4_GWAS-Catalog-r2019-05-03-X204.4_PT_MGI_20200608 P&T PRSWEB_PHECODE204.4_GWAS-Catalog-r2019-05-03-X204.4_PT_MGI_20200608 204.4 Multiple myeloma (hyperdiploidy);Multiple myeloma (IgH translocation);Multiple myeloma;Multiple myeloma and monoclonal gammopathy Binary 70 unique SNPs MGI Michigan Genomics Initiative P&T GWAS Catalog (2019-05-03) 22120009;23502783;23955597;26007630;27363682;30213928 https://www.ncbi.nlm.nih.gov/pubmed/?term=22120009+23502783+23955597+26007630+27363682+30213928 45 0.51 0.0241372 0.0827 0.516 0.443-0.583 OR 0 0-0 0 0-0 0.232 0.0135-4 0.232 0.0135-4 1.2 0.474-3.02 1.2 0.474-3.02 1.45 0.757-2.77 1.45 0.757-2.77 1.35 0.83-2.18 1.35 0.83-2.18 0.568 0.29-1.11 0.099 0.778 0.419-1.44 0.425 1.09 0.612-1.95 0.764 False False False False Both 83 825 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode204-4-ukbb-saige-hrc-x204-4-pt-mgi-20200608 prsweb-phecode204-4-ukbb-saige-hrc-x204-4-pt-mgi-20200608 PRSWEB_PHECODE204.4_UKBB-SAIGE-HRC-X204.4_PT_MGI_20200608 P&T PRSWEB_PHECODE204.4_UKBB-SAIGE-HRC-X204.4_PT_MGI_20200608 204.4 Multiple myeloma Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative P&T UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 10 0.81 0.00459676 0.0827 0.499 0.439-0.56 OR 0 0-0 0 0-0 0.278 0.016-4.85 0.278 0.016-4.85 0.785 0.257-2.39 0.785 0.257-2.39 0.635 0.261-1.54 0.635 0.261-1.54 1.03 0.616-1.73 1.03 0.616-1.73 0.793 0.414-1.52 0.483 1.19 0.646-2.18 0.583 0.977 0.521-1.83 0.943 False False False False Both 83 825 GRCh37/hg19 P<=5e-06 2020-06-08 prsweb-phecode204-4-20001-1050-prs-cs-mgi-20200608 prsweb-phecode204-4-20001-1050-prs-cs-mgi-20200608 PRSWEB_PHECODE204.4_20001-1050_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE204.4_20001-1050_PRS-CS_MGI_20200608 204.4 Cancer code, self-reported: multiple myeloma Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative PRS-CS UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 872863 0.54 0.00213323 0.0827 0.513 0.448-0.579 OR 0 0-0 0 0-0 1.84 0.555-6.11 1.84 0.555-6.11 1.28 0.508-3.2 1.28 0.508-3.2 1.56 0.822-2.96 1.56 0.822-2.96 1.16 0.706-1.91 1.16 0.706-1.91 0.938 0.5-1.76 0.841 0.957 0.506-1.81 0.892 1.09 0.596-2 0.776 False False False False Both 83 825 GRCh37/hg19 auto 2020-06-08 prsweb-phecode204-4-c-multiple-myeloma-plasma-cell-prs-cs-mgi-20200608 prsweb-phecode204-4-c-multiple-myeloma-plasma-cell-prs-cs-mgi-20200608 PRSWEB_PHECODE204.4_C-MULTIPLE-MYELOMA-PLASMA-CELL_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE204.4_C-MULTIPLE-MYELOMA-PLASMA-CELL_PRS-CS_MGI_20200608 204.4 Multiple myeloma and malignant plasma cell neoplasms Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative PRS-CS UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1060905 0.42 0.000595922 0.0827 0.531 0.47-0.596 OR 1.5 0.243-9.19 1.5 0.243-9.19 1.44 0.363-5.7 1.44 0.363-5.7 1.26 0.501-3.16 1.26 0.501-3.16 1.25 0.633-2.47 1.25 0.633-2.47 0.901 0.533-1.52 0.901 0.533-1.52 1.03 0.528-1.99 0.94 1.52 0.82-2.81 0.184 1.07 0.556-2.06 0.841 False False False False Both 83 825 GRCh37/hg19 auto 2020-06-08 prsweb-phecode204-4-c90-prs-cs-mgi-20200608 prsweb-phecode204-4-c90-prs-cs-mgi-20200608 PRSWEB_PHECODE204.4_C90_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE204.4_C90_PRS-CS_MGI_20200608 204.4 Diagnoses - main ICD10: C90 Multiple myeloma and malignant plasma cell neoplasms Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative PRS-CS UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1064537 0.15 0.000154242 0.0826 0.554 0.489-0.616 OR 2.51 0.571-11 2.51 0.571-11 1.4 0.354-5.51 1.4 0.354-5.51 1.22 0.482-3.08 1.22 0.482-3.08 1.06 0.522-2.17 1.06 0.522-2.17 1.4 0.866-2.28 1.4 0.866-2.28 1.81 0.894-3.65 0.0991 1.49 0.742-2.97 0.263 2.01 1.03-3.92 0.0409 False False False False Both 83 825 GRCh37/hg19 auto 2020-06-08 prsweb-phecode204-4-ukbb-saige-hrc-x204-4-prs-cs-mgi-20200608 prsweb-phecode204-4-ukbb-saige-hrc-x204-4-prs-cs-mgi-20200608 PRSWEB_PHECODE204.4_UKBB-SAIGE-HRC-X204.4_PRS-CS_MGI_20200608 PRS-CS PRSWEB_PHECODE204.4_UKBB-SAIGE-HRC-X204.4_PRS-CS_MGI_20200608 204.4 Multiple myeloma Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative PRS-CS UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 1119238 0.43 4.09017e-05 0.0827 0.532 0.467-0.599 OR 1.52 0.25-9.32 1.52 0.25-9.32 1.33 0.337-5.24 1.33 0.337-5.24 0.997 0.367-2.71 0.997 0.367-2.71 1.09 0.537-2.22 1.09 0.537-2.22 1.28 0.786-2.08 1.28 0.786-2.08 1.31 0.679-2.51 0.423 1.28 0.653-2.53 0.468 1.47 0.771-2.79 0.243 False False False False Both 83 825 GRCh37/hg19 auto 2020-06-08 prsweb-phecode204-4-20001-1050-lassosum-mgi-20200608 prsweb-phecode204-4-20001-1050-lassosum-mgi-20200608 PRSWEB_PHECODE204.4_20001-1050_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE204.4_20001-1050_LASSOSUM_MGI_20200608 204.4 Cancer code, self-reported: multiple myeloma Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative lassosum UKB GWAS (PHESANT) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 37583 0.69 0.000952588 0.0827 0.518 0.455-0.578 OR 0 0-0 0 0-0 0.864 0.158-4.74 0.864 0.158-4.74 0.815 0.268-2.48 0.815 0.268-2.48 0.747 0.327-1.7 0.747 0.327-1.7 1.09 0.66-1.81 1.09 0.66-1.81 1.13 0.585-2.19 0.714 1.4 0.743-2.62 0.301 1.2 0.637-2.27 0.57 False False False False Both 83 825 GRCh37/hg19 s=0.2;Lambda=0.07848 2020-06-08 prsweb-phecode204-4-c-multiple-myeloma-plasma-cell-lassosum-mgi-20200608 prsweb-phecode204-4-c-multiple-myeloma-plasma-cell-lassosum-mgi-20200608 PRSWEB_PHECODE204.4_C-MULTIPLE-MYELOMA-PLASMA-CELL_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE204.4_C-MULTIPLE-MYELOMA-PLASMA-CELL_LASSOSUM_MGI_20200608 204.4 Multiple myeloma and malignant plasma cell neoplasms Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative lassosum UKB GWAS (FINNGEN) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 31983 0.17 0.00597942 0.0826 0.544 0.477-0.618 OR 1.55 0.252-9.5 1.55 0.252-9.5 0.732 0.131-4.08 0.732 0.131-4.08 1.77 0.783-4 1.77 0.783-4 1.7 0.915-3.18 1.7 0.915-3.18 1.51 0.936-2.43 1.51 0.936-2.43 1.13 0.58-2.21 0.715 1.05 0.539-2.05 0.882 1.73 0.928-3.24 0.0842 False False False False Both 83 825 GRCh37/hg19 s=0.9;Lambda=0.06158 2020-06-08 prsweb-phecode204-4-c90-lassosum-mgi-20200608 prsweb-phecode204-4-c90-lassosum-mgi-20200608 PRSWEB_PHECODE204.4_C90_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE204.4_C90_LASSOSUM_MGI_20200608 204.4 Diagnoses - main ICD10: C90 Multiple myeloma and malignant plasma cell neoplasms Binary GWAS round 2: Results shared 1st August 2018. Imputed genotypes from HRC plus UK10K & 1000 Genomes reference panels as released by UK Biobank in March 2018. MGI Michigan Genomics Initiative lassosum UKB GWAS (ICD10) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 68757 0.7 0.00253686 0.0827 0.501 0.432-0.581 OR 3.83 1.04-14.1 3.83 1.04-14.1 3.19 1.16-8.77 3.19 1.16-8.77 2.46 1.16-5.2 2.46 1.16-5.2 2.16 1.2-3.86 2.16 1.2-3.86 1.36 0.84-2.21 1.36 0.84-2.21 0.734 0.388-1.39 0.341 0.61 0.317-1.17 0.137 1.03 0.576-1.83 0.932 False False False False Both 83 825 GRCh37/hg19 s=1;Lambda=0.06158 2020-06-08 prsweb-phecode204-4-ukbb-saige-hrc-x204-4-lassosum-mgi-20200608 prsweb-phecode204-4-ukbb-saige-hrc-x204-4-lassosum-mgi-20200608 PRSWEB_PHECODE204.4_UKBB-SAIGE-HRC-X204.4_LASSOSUM_MGI_20200608 Lassosum PRSWEB_PHECODE204.4_UKBB-SAIGE-HRC-X204.4_LASSOSUM_MGI_20200608 204.4 Multiple myeloma Binary ICD9 and ICD10 based PheWAS codes MGI Michigan Genomics Initiative lassosum UKB GWAS (PheCode) UKB_GWAS https://www.ncbi.nlm.nih.gov/pubmed/?term=30104761 614225 0.27 0.00481423 0.0826 0.539 0.473-0.603 OR 1.52 0.247-9.42 1.52 0.247-9.42 1.35 0.342-5.34 1.35 0.342-5.34 1.23 0.491-3.1 1.23 0.491-3.1 1.12 0.55-2.27 1.12 0.55-2.27 1.17 0.714-1.93 1.17 0.714-1.93 0.864 0.435-1.71 0.676 1.38 0.744-2.55 0.308 1.28 0.685-2.4 0.436 False False False False Both 83 825 GRCh37/hg19 s=0.2;Lambda=0.01438 2020-06-08