phewas_code phewas_string sex MatchedCases MatchedControls groupnum group color N N_Q1 N_Q2 N_Q3 N_Q4 PRS_BETA PRS_SEBETA PRS_P PRS_LOG10P PRS_OR PRS_CI1 PRS_CI2 Q1Q2_BETA Q1Q2_SEBETA Q1Q2_P Q1Q2_LOG10P Q1Q2_OR Q1Q2_CI1 Q1Q2_CI2 Q1Q3_BETA Q1Q3_SEBETA Q1Q3_P Q1Q3_LOG10P Q1Q3_OR Q1Q3_CI1 Q1Q3_CI2 Q1Q4_BETA Q1Q4_SEBETA Q1Q4_P Q1Q4_LOG10P Q1Q4_OR Q1Q4_CI1 Q1Q4_CI2 predictor exclude 008 Intestinal infection Both 179 806 1 infectious diseases blue 806, 179 125, 28 266, 57 136, 25 202, 44 -0.0821 0.087 0.345 0.462 0.921 0.765 1.08 -0.0155 0.263 0.953 0.021 0.985 0.593 1.67 -0.152 0.299 0.612 0.213 0.859 0.475 1.55 -0.0642 0.272 0.813 0.09 0.938 0.552 1.61 PRS_PLINK_1.99526231496888e.08 FALSE 008.5 Bacterial enteritis Both 57 348 1 infectious diseases blue 348, 57 50, 6 94, 14 81, 15 86, 16 0.0967 0.117 0.41 0.388 1.1 0.863 1.36 0.115 0.497 0.818 0.087 1.12 0.427 3.22 0.271 0.499 0.587 0.232 1.31 0.501 3.76 0.278 0.507 0.583 0.234 1.32 0.498 3.85 PRS_PLINK_1.99526231496888e.08 FALSE 008.52 Intestinal infection due to C. difficile Both 40 258 1 infectious diseases blue 258, 40 38, 5 74, 10 55, 9 64, 12 0.153 0.138 0.267 0.573 1.16 0.884 1.5 0.0988 0.583 0.866 0.063 1.1 0.358 3.79 -0.052 0.592 0.93 0.032 0.949 0.295 3.21 0.206 0.561 0.713 0.147 1.23 0.418 3.97 PRS_PLINK_1.99526231496888e.08 TRUE 008.6 Viral Enteritis Both 70 261 1 infectious diseases blue 261, 70 46, 8 65, 20 65, 16 65, 18 -0.00545 0.173 0.975 0.011 0.995 0.687 1.36 0.619 0.482 0.199 0.702 1.86 0.749 5.01 0.373 0.487 0.443 0.353 1.45 0.57 3.9 0.352 0.467 0.451 0.346 1.42 0.585 3.67 PRS_PLINK_1.99526231496888e.08 FALSE 010 Tuberculosis Both 14 58 1 infectious diseases blue 58, 14 9, 2 14, 4 14, 2 15, 5 0.281 0.397 0.479 0.32 1.32 0.607 2.72 0.442 1.12 0.693 0.159 1.56 0.202 1.78 -0.622 1.53 0.685 0.164 0.537 0.00785 11.7 -1.11 1.43 0.439 0.358 0.33 0.00586 4.3 PRS_PLINK_1.99526231496888e.08 TRUE 031 Diseases due to other mycobacteria Both 2 16 1 infectious diseases blue 16, 2 1, 0 4, 0 4, 1 4, 1 0.035 295 1 0 1.04 0.829 1.54 0.489 8240 1 0 1.63 0.342 2.67 -0.27 15700 1 0 0.764 0.131 2.67 PRS_PLINK_1.99526231496888e.08 TRUE 038 Septicemia Both 85 492 1 infectious diseases blue 492, 85 73, 11 174, 33 74, 12 121, 19 -0.0251 0.126 0.842 0.075 0.975 0.737 1.22 0.266 0.374 0.478 0.321 1.3 0.643 2.82 0.153 0.441 0.728 0.138 1.17 0.488 2.82 0.0318 0.416 0.939 0.027 1.03 0.459 2.41 PRS_PLINK_1.99526231496888e.08 FALSE 038.1 Gram negative septicemia Both 22 114 1 infectious diseases blue 114, 22 21, 6 31, 6 24, 4 27, 2 -0.666 0.309 0.0313 1.505 0.514 0.274 0.952 -0.167 0.707 0.813 0.09 0.846 0.216 3.36 -0.354 0.701 0.613 0.212 0.702 0.173 2.72 -0.801 0.858 0.351 0.455 0.449 0.0709 2.43 PRS_PLINK_1.99526231496888e.08 TRUE 038.2 Gram positive septicemia Both 6 49 1 infectious diseases blue 49, 6 8, 1 12, 2 12, 0 12, 2 0.0442 0.594 0.941 0.027 1.05 0.329 3.83 0.942 1.46 0.519 0.285 2.57 0.183 390 -0.984 1.44 0.496 0.305 0.374 0.00438 7.27 -0.476 1.87 0.799 0.098 0.621 0.000714 121 PRS_PLINK_1.99526231496888e.08 TRUE 038.3 Bacteremia Both 39 227 1 infectious diseases blue 227, 39 39, 9 77, 11 36, 10 57, 8 0.2 0.136 0.141 0.851 1.22 0.922 1.55 -0.317 0.504 0.529 0.276 0.728 0.274 1.99 0.0326 0.511 0.949 0.023 1.03 0.38 2.81 -0.163 0.57 0.775 0.111 0.85 0.277 2.71 PRS_PLINK_1.99526231496888e.08 TRUE 041 Bacterial infection NOS Both 226 998 1 infectious diseases blue 998, 226 142, 25 332, 83 166, 38 250, 59 -2.47e-05 0.0731 1 0 1 0.858 1.14 0.314 0.25 0.208 0.681 1.37 0.849 2.27 0.3 0.282 0.288 0.541 1.35 0.78 2.37 0.258 0.26 0.321 0.493 1.29 0.784 2.19 PRS_PLINK_1.99526231496888e.08 FALSE 041.1 Staphylococcus infections Both 55 364 1 infectious diseases blue 364, 55 53, 5 116, 24 66, 8 91, 14 0.013 0.119 0.913 0.04 1.01 0.78 1.25 0.732 0.516 0.156 0.807 2.08 0.796 6.42 0.338 0.559 0.545 0.263 1.4 0.457 4.67 0.333 0.536 0.535 0.272 1.39 0.494 4.42 PRS_PLINK_1.99526231496888e.08 FALSE 041.11 Methicillin sensitive Staphylococcus aureus Both 29 192 1 infectious diseases blue 192, 29 34, 4 57, 13 36, 2 48, 8 -0.134 0.194 0.489 0.311 0.874 0.615 1.3 0.595 0.601 0.323 0.491 1.81 0.592 6.5 -0.517 0.843 0.54 0.268 0.596 0.089 3.4 0.0976 0.69 0.888 0.052 1.1 0.271 4.77 PRS_PLINK_1.99526231496888e.08 TRUE 041.12 Methicillin resistant Staphylococcus aureus Both 28 174 1 infectious diseases blue 174, 28 31, 4 48, 13 39, 3 43, 5 -0.086 0.178 0.628 0.202 0.918 0.628 1.27 0.346 0.616 0.575 0.241 1.41 0.444 5.07 -0.308 0.735 0.675 0.171 0.735 0.158 3.36 -0.704 0.739 0.341 0.467 0.495 0.0971 2.19 PRS_PLINK_1.99526231496888e.08 TRUE 041.2 Streptococcus infection Both 61 350 1 infectious diseases blue 350, 61 51, 7 118, 21 57, 9 86, 14 -0.182 0.158 0.25 0.602 0.833 0.587 1.11 0.31 0.465 0.505 0.297 1.36 0.569 3.6 0.632 0.566 0.264 0.578 1.88 0.633 6.08 0.116 0.504 0.817 0.088 1.12 0.42 3.23 PRS_PLINK_1.99526231496888e.08 FALSE 041.21 Rheumatic fever / chorea Both 7 49 1 infectious diseases blue 49, 7 6, 2 12, 3 12, 0 12, 1 -0.0412 0.412 0.92 0.036 0.96 0.205 1.81 -1.68 1.45 0.247 0.607 0.187 0.00339 2.16 -2.03 2.4 0.399 0.399 0.132 0.000178 6.33 -0.202 1.36 0.882 0.055 0.817 0.0224 15.9 PRS_PLINK_1.99526231496888e.08 TRUE 041.4 E. coli Both 45 283 1 infectious diseases blue 283, 45 43, 5 88, 15 52, 8 71, 13 0.0187 0.136 0.891 0.05 1.02 0.712 1.27 0.267 0.538 0.619 0.208 1.31 0.474 4.05 0.423 0.588 0.472 0.326 1.53 0.487 5.19 0.384 0.556 0.49 0.31 1.47 0.509 4.79 PRS_PLINK_1.99526231496888e.08 TRUE 041.8 H. pylori Both 11 75 1 infectious diseases blue 75, 11 10, 1 20, 0 17, 7 19, 2 0.114 0.373 0.759 0.12 1.12 0.539 2.44 -1.36 1.44 0.343 0.464 0.256 0.000571 6.57 0.328 1.1 0.765 0.116 1.39 0.194 17.8 -0.821 1.32 0.533 0.273 0.44 0.0238 8.87 PRS_PLINK_1.99526231496888e.08 TRUE 041.9 Infection with drug-resistant microorganisms Both 12 90 1 infectious diseases blue 90, 12 17, 2 27, 3 16, 2 23, 4 0.139 0.232 0.548 0.261 1.15 0.783 2 0.0316 1.02 0.975 0.011 1.03 0.122 10.2 0.0894 0.917 0.922 0.035 1.09 0.179 6.97 0.216 1.59 0.892 0.049 1.24 0.00594 329 PRS_PLINK_1.99526231496888e.08 TRUE 053 Herpes zoster Both 89 246 1 infectious diseases blue 246, 89 37, 10 78, 33 45, 13 61, 28 0.195 0.173 0.261 0.584 1.21 0.869 1.71 0.226 0.429 0.599 0.223 1.25 0.557 2.96 0.0415 0.494 0.933 0.03 1.04 0.401 2.73 0.653 0.47 0.165 0.783 1.92 0.795 4.92 PRS_PLINK_1.99526231496888e.08 FALSE 053.1 Herpes zoster with nervous system complications Both 7 42 1 infectious diseases blue 42, 7 6, 3 10, 2 10, 2 11, 0 0.0979 0.544 0.857 0.067 1.1 0.382 3.55 0.392 1.43 0.784 0.105 1.48 0.109 61.4 -0.568 1.35 0.674 0.171 0.566 0.000787 7.26 -1.82 2.29 0.425 0.371 0.162 0.00128 142 PRS_PLINK_1.99526231496888e.08 TRUE 054 Herpes simplex Both 109 356 1 infectious diseases blue 356, 109 48, 15 110, 39 70, 17 87, 25 0.0705 0.103 0.495 0.305 1.07 0.871 1.3 0.0259 0.354 0.942 0.026 1.03 0.523 2.08 -0.365 0.415 0.379 0.421 0.694 0.307 1.56 -0.0568 0.391 0.885 0.053 0.945 0.446 2.05 PRS_PLINK_1.99526231496888e.08 FALSE 070 Viral hepatitis Both 23 112 1 infectious diseases blue 112, 23 16, 3 42, 9 15, 3 27, 8 0.415 0.312 0.184 0.734 1.51 0.835 2.88 0.502 0.88 0.568 0.245 1.65 0.329 13.3 0.311 1.08 0.773 0.112 1.36 0.172 23.1 0.317 0.804 0.693 0.159 1.37 0.322 6.98 PRS_PLINK_1.99526231496888e.08 TRUE 070.1 Viral hepatitis A Both 4 9 1 infectious diseases blue 9, 4 1, 2 2, 2 2, 0 2, 0 -0.89 3.37 0.792 0.101 0.411 0.00214 219 0.0202 179 1 0 1.02 0.239 5.33 -5.65 851 0.995 0.002 0.00353 1.35e-09 19900 0.103 2550 1 0 1.11 0.361 3.44 PRS_PLINK_1.99526231496888e.08 TRUE 070.2 Viral hepatitis B Both 7 22 1 infectious diseases blue 22, 7 2, 0 5, 1 5, 1 6, 5 1.17 0.779 0.134 0.872 3.21 0.905 28.3 -0.142 9160000 1 0 0.867 0.00118 104 1.31 851 0.999 0.001 3.71 7.82e-11 4.25e+13 1.2 2.94 0.682 0.166 3.33 0.0419 8120 PRS_PLINK_1.99526231496888e.08 TRUE 070.3 Viral hepatitis C Both 12 66 1 infectious diseases blue 66, 12 12, 2 15, 1 16, 3 17, 6 0.805 0.48 0.0931 1.031 2.24 0.907 6.87 -1.04 1.34 0.436 0.361 0.353 0.00944 4.34 -0.449 1.11 0.685 0.164 0.638 0.0286 5.29 0.0802 1.19 0.946 0.024 1.08 0.11 11.6 PRS_PLINK_1.99526231496888e.08 TRUE 070.4 Chronic hepatitis Both 10 30 1 infectious diseases blue 30, 10 6, 2 10, 4 4, 1 8, 3 -0.104 0.388 0.787 0.104 0.901 0.375 1.82 1.39 1.46 0.34 0.469 4.03 0.3 66.2 0.428 3.62 0.906 0.043 1.53 1.61e-05 1370 0.864 1.69 0.609 0.216 2.37 0.0141 160 PRS_PLINK_1.99526231496888e.08 TRUE 070.9 Hepatitis NOS Both 34 130 1 infectious diseases blue 130, 34 22, 4 37, 9 27, 7 33, 11 0.0235 0.255 0.927 0.033 1.02 0.625 1.71 0.000486 0.657 0.999 0 1 0.284 3.78 0.44 0.731 0.547 0.262 1.55 0.394 6.67 0.551 0.723 0.446 0.351 1.74 0.455 7.87 PRS_PLINK_1.99526231496888e.08 TRUE 071 Human immunodeficiency virus [HIV] disease Both 11 25 1 infectious diseases blue 25, 11 5, 1 7, 1 4, 3 6, 4 0.0384 0.612 0.95 0.022 1.04 0.337 3.1 0.42 2.23 0.851 0.07 1.52 0.0439 604 0.215 2.23 0.923 0.035 1.24 0.0279 599 1.45 1.82 0.426 0.37 4.27 0.35 2250 PRS_PLINK_1.99526231496888e.08 TRUE 071.1 HIV infection, symptomatic Both 8 19 1 infectious diseases blue 19, 8 2, 0 6, 1 3, 3 5, 2 -0.166 0.669 0.804 0.095 0.847 0.231 2.75 -0.95 22.6 0.966 0.015 0.387 0.364 0.411 0.122 157 0.999 0 1.13 0.723 2.98 -0.907 33.7 0.979 0.009 0.404 0.0934 0.0941 PRS_PLINK_1.99526231496888e.08 TRUE 078 Viral warts & HPV Both 235 577 1 infectious diseases blue 577, 235 82, 23 182, 87 104, 37 142, 65 0.106 0.0809 0.191 0.719 1.11 0.949 1.3 0.486 0.274 0.0761 1.119 1.63 0.965 2.81 0.228 0.308 0.46 0.337 1.26 0.694 2.31 0.444 0.282 0.115 0.938 1.56 0.912 2.73 PRS_PLINK_1.99526231496888e.08 FALSE 079 Viral infection Both 449 612 1 infectious diseases blue 612, 449 87, 53 195, 170 109, 74 153, 107 0.0341 0.0661 0.606 0.217 1.03 0.91 1.18 0.39 0.212 0.0658 1.181 1.48 0.981 2.24 0.0957 0.235 0.684 0.165 1.1 0.699 1.74 0.217 0.223 0.331 0.48 1.24 0.808 1.92 PRS_PLINK_1.99526231496888e.08 FALSE 079.1 Varicella infection Both 253 581 1 infectious diseases blue 581, 253 84, 34 187, 95 102, 47 144, 56 -0.0449 0.0944 0.634 0.198 0.956 0.792 1.15 0.262 0.254 0.302 0.519 1.3 0.798 2.15 0.119 0.276 0.667 0.176 1.13 0.661 1.93 0.0194 0.268 0.942 0.026 1.02 0.608 1.73 PRS_PLINK_1.99526231496888e.08 FALSE 079.2 Infectious mononucleosis Both 20 58 1 infectious diseases blue 58, 20 9, 1 16, 8 12, 2 15, 8 0.235 0.226 0.299 0.524 1.26 0.871 2.03 0.755 1.45 0.603 0.219 2.13 0.117 217 -0.328 1.7 0.847 0.072 0.72 0.02 70.7 3.28 2.35 0.163 0.789 26.7 0.809 663000 PRS_PLINK_1.99526231496888e.08 TRUE 079.9 Viremia, NOS Both 65 177 1 infectious diseases blue 177, 65 23, 4 56, 23 32, 10 44, 24 0.252 0.179 0.16 0.797 1.29 0.929 1.88 0.809 0.595 0.174 0.76 2.25 0.76 7.93 0.938 0.747 0.209 0.679 2.55 0.64 12 0.973 0.616 0.114 0.942 2.65 0.851 9.74 PRS_PLINK_1.99526231496888e.08 FALSE 080 Postoperative infection Both 94 692 1 infectious diseases blue 692, 94 98, 17 239, 36 105, 13 172, 18 -0.243 0.137 0.0757 1.121 0.784 0.593 1.02 -0.187 0.324 0.565 0.248 0.83 0.443 1.6 -0.511 0.401 0.203 0.693 0.6 0.267 1.31 -0.624 0.365 0.0873 1.059 0.536 0.258 1.11 PRS_PLINK_1.99526231496888e.08 FALSE 081 Infection/inflammation of internal prosthetic device; implant; and graft Both 54 331 1 infectious diseases blue 331, 54 42, 7 85, 11 80, 17 83, 15 0.0685 0.149 0.645 0.19 1.07 0.769 1.39 -0.114 0.521 0.827 0.082 0.892 0.324 2.59 0.283 0.505 0.575 0.241 1.33 0.51 3.76 0.0802 0.484 0.868 0.061 1.08 0.43 2.94 PRS_PLINK_1.99526231496888e.08 FALSE 090 Sexually transmitted infections (not HIV or hepatitis) Both 78 406 1 infectious diseases blue 406, 78 60, 9 136, 26 64, 12 102, 20 0.0121 0.154 0.937 0.028 1.01 0.74 1.36 0.0927 0.414 0.823 0.085 1.1 0.496 2.58 0.207 0.465 0.656 0.183 1.23 0.495 3.13 0.25 0.439 0.569 0.245 1.28 0.545 3.19 PRS_PLINK_1.99526231496888e.08 FALSE 110 Dermatophytosis / Dermatomycosis Both 206 601 1 infectious diseases blue 601, 206 84, 29 189, 87 111, 26 150, 44 -0.0468 0.0872 0.591 0.228 0.954 0.796 1.12 0.234 0.258 0.363 0.44 1.26 0.773 2.1 -0.543 0.326 0.0958 1.018 0.581 0.307 1.09 -0.159 0.279 0.569 0.245 0.853 0.497 1.48 PRS_PLINK_1.99526231496888e.08 FALSE 110.1 Dermatophytosis Both 186 527 1 infectious diseases blue 527, 186 69, 22 174, 82 89, 20 132, 42 -0.0404 0.0894 0.652 0.186 0.96 0.796 1.13 0.292 0.285 0.305 0.515 1.34 0.779 2.36 -0.447 0.363 0.218 0.662 0.639 0.314 1.29 -0.0629 0.306 0.837 0.077 0.939 0.521 1.72 PRS_PLINK_1.99526231496888e.08 FALSE 110.11 Dermatophytosis of nail Both 106 293 1 infectious diseases blue 293, 106 41, 17 100, 49 45, 9 73, 22 -0.102 0.132 0.443 0.354 0.903 0.671 1.14 0.125 0.347 0.72 0.143 1.13 0.587 2.24 -0.759 0.513 0.139 0.858 0.468 0.169 1.23 -0.243 0.383 0.525 0.28 0.784 0.377 1.65 PRS_PLINK_1.99526231496888e.08 FALSE 110.12 Althete's foot Both 54 159 1 infectious diseases blue 159, 54 17, 5 55, 29 24, 6 40, 9 -0.12 0.184 0.515 0.288 0.887 0.594 1.23 0.346 0.563 0.539 0.268 1.41 0.504 4.44 0.0128 0.751 0.986 0.006 1.01 0.236 4.55 -0.58 0.697 0.405 0.392 0.56 0.145 2.13 PRS_PLINK_1.99526231496888e.08 FALSE 110.13 Dermatophytosis of the body Both 57 168 1 infectious diseases blue 168, 57 24, 6 57, 23 27, 7 42, 14 0.0698 0.133 0.599 0.223 1.07 0.813 1.36 0.555 0.545 0.308 0.511 1.74 0.642 5.21 0.0333 0.676 0.961 0.017 1.03 0.283 3.94 0.0806 0.658 0.902 0.045 1.08 0.297 4.07 PRS_PLINK_1.99526231496888e.08 FALSE 110.2 Dermatomycoses Both 35 102 1 infectious diseases blue 102, 35 14, 5 33, 14 18, 3 25, 11 0.0814 0.151 0.59 0.229 1.08 0.818 1.43 -0.412 0.702 0.557 0.254 0.662 0.172 2.63 -0.738 0.873 0.398 0.4 0.478 0.0835 2.31 0.0888 0.663 0.893 0.049 1.09 0.319 3.91 PRS_PLINK_1.99526231496888e.08 TRUE 112 Candidiasis Both 255 756 1 infectious diseases blue 756, 255 102, 29 241, 99 140, 36 185, 70 0.0499 0.0711 0.483 0.316 1.05 0.913 1.2 0.356 0.25 0.154 0.813 1.43 0.886 2.35 -0.16 0.286 0.576 0.239 0.852 0.49 1.49 0.261 0.256 0.309 0.511 1.3 0.795 2.16 PRS_PLINK_1.99526231496888e.08 FALSE 112.3 Candidiasis of skin and nails Both 39 174 1 infectious diseases blue 174, 39 26, 7 50, 14 36, 5 44, 9 -0.0484 0.195 0.804 0.095 0.953 0.613 1.34 -0.206 0.539 0.702 0.153 0.814 0.291 2.36 -0.335 0.697 0.631 0.2 0.715 0.18 2.77 -0.287 0.562 0.61 0.214 0.751 0.248 2.25 PRS_PLINK_1.99526231496888e.08 TRUE 117 Mycoses Both 36 126 1 infectious diseases blue 126, 36 21, 8 42, 15 19, 3 32, 8 -0.0618 0.273 0.821 0.086 0.94 0.556 1.6 0.153 0.56 0.785 0.105 1.17 0.412 3.5 -0.0283 0.874 0.974 0.011 0.972 0.172 5.3 0.416 0.705 0.555 0.256 1.52 0.418 6.31 PRS_PLINK_1.99526231496888e.08 TRUE 117.1 Histoplasmosis Both 4 15 1 infectious diseases blue 15, 4 2, 3 4, 1 3, 0 4, 0 0.228 1.04 0.827 0.083 1.26 0.0888 22.3 -1.49 4.28 0.727 0.138 0.224 0.198 0.269 -0.00291 3950 1 0 0.997 0.362 3.61 -1.07 2450 1 0 0.343 0.102 2.26 PRS_PLINK_1.99526231496888e.08 TRUE 117.4 Aspergillosis Both 8 22 1 infectious diseases blue 22, 8 5, 3 5, 4 5, 0 6, 1 0.0473 0.952 0.96 0.018 1.05 0.165 8.96 0.728 1.26 0.564 0.249 2.07 0.266 52.4 -0.276 1.99 0.89 0.051 0.759 0.0169 48.1 -0.071 2.18 0.974 0.011 0.931 0.0122 33.1 PRS_PLINK_1.99526231496888e.08 TRUE 130 Spirochetal infection Both 9 39 1 infectious diseases blue 39, 9 5, 0 12, 4 7, 0 10, 3 0.0755 0.698 0.914 0.039 1.08 0.246 5.01 1.39 1.88 0.459 0.338 4.02 0.184 733 0.402 1.93 0.835 0.078 1.49 0.0142 2840 PRS_PLINK_1.99526231496888e.08 TRUE 130.1 Lyme disease Both 7 29 1 infectious diseases blue 29, 7 5, 0 8, 4 6, 1 7, 2 0.192 0.768 0.803 0.096 1.21 0.25 6.01 3.89 3.83 0.309 0.51 49.1 0.165 19600000 0.352 2.67 0.895 0.048 1.42 0.0216 879 0.585 1.92 0.76 0.119 1.8 0.0596 73.5 PRS_PLINK_1.99526231496888e.08 TRUE 131 Protozoan infection Both 9 34 1 infectious diseases blue 34, 9 7, 2 11, 5 5, 0 9, 2 -0.0569 0.633 0.928 0.032 0.945 0.262 3.33 -0.213 1.11 0.848 0.072 0.808 0.0947 6.39 -1.6 1.79 0.37 0.432 0.201 0.00192 2.95 -0.663 1.2 0.582 0.235 0.515 0.0595 3.98 PRS_PLINK_1.99526231496888e.08 TRUE 132 Infestation (lice, mites) Both 13 52 1 infectious diseases blue 52, 13 8, 2 15, 2 11, 4 13, 4 0.00607 0.446 0.989 0.005 1.01 0.427 2.41 -0.923 1.11 0.405 0.393 0.397 0.0304 2.92 -0.22 1.09 0.841 0.075 0.802 0.113 6.55 0.247 1.07 0.817 0.088 1.28 0.194 10.1 PRS_PLINK_1.99526231496888e.08 TRUE 134 Helminthiases Both 3 22 1 infectious diseases blue 22, 3 3, 1 6, 0 4, 0 6, 2 1.04 1.03 0.312 0.505 2.83 0.448 1490 -0.936 2.9 0.747 0.127 0.392 0.00405 33.4 0.479 1350 1 0 1.61 0.121 14.8 -0.379 2.36 0.872 0.059 0.684 0.0143 33 PRS_PLINK_1.99526231496888e.08 TRUE 134.1 Intestinal helminthiases Both 2 11 1 infectious diseases blue 11, 2 2, 1 2, 0 2, 0 3, 1 1.22 2.39 0.608 0.216 3.4 0.0969 454 -0.0776 7970 1 0 0.925 0.206 2.31 -0.129 8560 1 0 0.879 0.8 3.75 -0.12 42.2 0.998 0.001 0.887 0.562 1.5 PRS_PLINK_1.99526231496888e.08 TRUE 136 Other infectious and parasitic diseases Both 182 876 1 infectious diseases blue 876, 182 122, 21 295, 65 145, 33 215, 45 0.0718 0.0722 0.32 0.495 1.07 0.927 1.23 0.259 0.275 0.347 0.46 1.3 0.765 2.27 0.244 0.301 0.419 0.378 1.28 0.71 2.33 0.166 0.287 0.564 0.249 1.18 0.676 2.11 PRS_PLINK_1.99526231496888e.08 FALSE 145 Cancer of mouth Both 16 237 2 neoplasms darkcyan 237, 16 41, 3 84, 2 33, 4 59, 4 -0.165 0.297 0.579 0.237 0.848 0.431 1.48 -1.12 0.786 0.154 0.812 0.326 0.0504 1.79 0.466 0.777 0.549 0.261 1.59 0.325 9.03 -0.269 0.697 0.699 0.155 0.764 0.172 3.54 PRS_PLINK_1.99526231496888e.08 TRUE 145.1 Cancer of lip Both 2 15 2 neoplasms darkcyan 15, 2 1, 0 5, 1 2, 0 4, 1 0.411 0.95 0.666 0.177 1.51 0.272 11.1 0.393 3000 1 0 1.48 0.000581 104 -0.0181 929 1 0 0.982 0.949 2.61 PRS_PLINK_1.99526231496888e.08 TRUE 145.2 Cancer of tongue Both 6 106 2 neoplasms darkcyan 106, 6 20, 2 36, 0 15, 1 27, 1 -1.39 0.659 0.0348 1.459 0.249 0.0357 0.918 -3.13 1.66 0.0597 1.224 0.0437 4.84e-05 1.16 -0.647 1.55 0.676 0.17 0.524 0.00177 23.8 -0.538 1.05 0.609 0.215 0.584 0.0499 5.83 PRS_PLINK_1.99526231496888e.08 TRUE 145.3 Cancer of major salivary glands Both 5 68 2 neoplasms darkcyan 68, 5 14, 1 19, 0 14, 3 17, 0 0.775 0.514 0.132 0.881 2.17 0.406 8.26 -1.1 1.25 0.382 0.418 0.334 0.0016 37.6 1.51 1.4 0.279 0.554 4.53 0.405 607 -1.12 1.35 0.41 0.388 0.327 0.000506 5.17 PRS_PLINK_1.99526231496888e.08 TRUE 145.4 Cancer of the gums Both 1 27 2 neoplasms darkcyan 27, 1 5, 0 9, 1 4, 0 7, 0 0.232 0.913 0.799 0.097 1.26 0.136 47 -0.0682 2.01 0.973 0.012 0.934 0.00435 76.3 PRS_PLINK_1.99526231496888e.08 TRUE 145.5 Cancer of the mouth floor Both 1 30 2 neoplasms darkcyan 30, 1 7, 0 9, 0 5, 1 8, 0 0.134 1.14 0.906 0.043 1.14 0.0264 69.2 0.676 2.46 0.783 0.106 1.97 0.0148 1630 PRS_PLINK_1.99526231496888e.08 TRUE 149 Cancer of larynx, pharynx, nasal cavities Both 16 218 2 neoplasms darkcyan 218, 16 39, 3 75, 4 34, 3 54, 4 -0.432 0.325 0.184 0.734 0.649 0.321 1.25 -0.254 0.689 0.713 0.147 0.776 0.179 3.59 -0.485 0.882 0.582 0.235 0.616 0.0815 3.81 0.0346 0.721 0.962 0.017 1.04 0.228 5.17 PRS_PLINK_1.99526231496888e.08 TRUE 149.1 Cancer of oropharynx Both 1 45 2 neoplasms darkcyan 45, 1 10, 1 12, 0 9, 0 11, 0 0.0812 0.42 0.846 0.072 1.08 0.0168 9.68 -0.905 1.42 0.524 0.28 0.404 0.00122 10.4 -0.708 1.48 0.633 0.199 0.493 0.00136 61.8 -1.62 1.6 0.311 0.507 0.197 0.000915 3.4 PRS_PLINK_1.99526231496888e.08 TRUE 149.2 Cancer of nasopharynx Both 7 33 2 neoplasms darkcyan 33, 7 6, 0 9, 2 7, 1 8, 2 -0.555 0.541 0.305 0.515 0.574 0.188 1.53 1.42 1.64 0.387 0.412 4.14 0.205 3810 -0.00321 1.82 0.999 0.001 0.997 0.0083 212 2.06 1.93 0.286 0.544 7.81 0.315 5260 PRS_PLINK_1.99526231496888e.08 TRUE 149.3 Cancer of hypopharynx Both 0 12 2 neoplasms darkcyan 12, 0 3 4 3 2 PRS_PLINK_1.99526231496888e.08 TRUE 149.4 Cancer of larynx Both 1 68 2 neoplasms darkcyan 68, 1 11, 0 21, 1 13, 0 17, 0 0.238 0.395 0.547 0.262 1.27 0.0797 3.05 0.298 1.36 0.827 0.083 1.35 0.0295 278 PRS_PLINK_1.99526231496888e.08 TRUE 149.5 Hx of malignant neoplasm of oral cavity and pharynx Both 7 90 2 neoplasms darkcyan 90, 7 17, 2 30, 1 14, 3 23, 1 -0.0749 0.37 0.839 0.076 0.928 0.273 1.72 -1.16 1.07 0.276 0.558 0.313 0.0208 2.7 0.11 0.956 0.908 0.042 1.12 0.146 7.44 -0.702 0.997 0.482 0.317 0.496 0.0402 4.38 PRS_PLINK_1.99526231496888e.08 TRUE 149.9 Cancer of of nasal cavities Both 2 51 2 neoplasms darkcyan 51, 2 9, 1 17, 0 8, 0 13, 1 0.0717 0.39 0.854 0.068 1.07 0.0272 2.21 -1.15 1.66 0.49 0.31 0.317 0.000406 7.98 0.385 2.11 0.855 0.068 1.47 0.000574 480 0.174 1.77 0.922 0.035 1.19 0.00397 207 PRS_PLINK_1.99526231496888e.08 TRUE 150 Cancer of esophagus Both 2 42 2 neoplasms darkcyan 42, 2 9, 1 15, 0 5, 0 11, 0 -0.097 0.775 0.9 0.046 0.908 0.0689 7.24 -0.264 1.6 0.869 0.061 0.768 0.00729 449 0.365 1.64 0.824 0.084 1.44 0.0243 122 -0.0569 1.73 0.974 0.012 0.945 0.00768 558 PRS_PLINK_1.99526231496888e.08 TRUE 151 Cancer of stomach Both 4 57 2 neoplasms darkcyan 57, 4 10, 3 20, 1 8, 0 14, 0 -0.791 0.599 0.187 0.728 0.454 0.104 1.5 -2.48 1.49 0.0972 1.012 0.0839 0.000739 1.23 -1.37 2.08 0.51 0.292 0.255 0.00154 8.92 -2.03 1.5 0.175 0.757 0.131 0.000769 1.7 PRS_PLINK_1.99526231496888e.08 TRUE 153 Colorectal cancer Both 33 208 2 neoplasms darkcyan 208, 33 27, 3 70, 15 34, 6 52, 4 -0.209 0.225 0.352 0.454 0.811 0.505 1.23 0.531 0.639 0.406 0.392 1.7 0.527 7.03 0.918 0.853 0.282 0.55 2.5 0.502 18.2 -0.0937 0.739 0.899 0.046 0.911 0.203 4.49 PRS_PLINK_1.99526231496888e.08 TRUE 153.2 Colon cancer Both 24 158 2 neoplasms darkcyan 158, 24 23, 4 49, 9 29, 3 40, 3 -0.359 0.271 0.185 0.733 0.698 0.396 1.18 0.0271 0.638 0.966 0.015 1.03 0.306 3.85 -0.152 0.811 0.851 0.07 0.859 0.158 4.94 -0.347 0.767 0.651 0.186 0.707 0.146 3.45 PRS_PLINK_1.99526231496888e.08 TRUE 153.3 Malignant neoplasm of rectum, rectosigmoid junction, and anus Both 16 134 2 neoplasms darkcyan 134, 16 19, 0 47, 11 19, 3 34, 2 0.121 0.244 0.62 0.207 1.13 0.632 1.71 1.94 1.32 0.143 0.846 6.95 0.816 870 3.1 1.91 0.105 0.98 22.2 0.744 172000 1.68 1.62 0.301 0.522 5.37 0.252 679000 PRS_PLINK_1.99526231496888e.08 TRUE 155 Cancer of liver and intrahepatic bile duct Both 6 70 2 neoplasms darkcyan 70, 6 12, 1 23, 2 10, 1 18, 2 1.61 0.901 0.0737 1.133 5.01 0.941 64.1 -0.0293 1.19 0.98 0.009 0.971 0.087 12 -1.36 2.25 0.546 0.263 0.257 2.09e-05 165 -0.505 1.26 0.689 0.162 0.603 0.00313 15 PRS_PLINK_1.99526231496888e.08 TRUE 155.1 Malignant neoplasm of liver, primary Both 5 53 2 neoplasms darkcyan 53, 5 9, 0 15, 2 11, 1 13, 2 1.42 0.886 0.108 0.965 4.15 0.833 46.5 1.71 1.87 0.36 0.443 5.54 0.27 8140 -0.556 1.92 0.773 0.112 0.574 0.000499 115 0.472 1.49 0.751 0.124 1.6 0.0339 159 PRS_PLINK_1.99526231496888e.08 TRUE 157 Pancreatic cancer Both 5 71 2 neoplasms darkcyan 71, 5 10, 0 19, 1 16, 4 18, 0 -0.26 0.684 0.704 0.153 0.771 0.135 3.82 0.458 1.56 0.768 0.114 1.58 0.00724 561 0.983 1.64 0.548 0.261 2.67 0.156 1080 PRS_PLINK_1.99526231496888e.08 TRUE 158 Neoplasm of unspecified nature of digestive system Both 56 263 2 neoplasms darkcyan 263, 56 37, 8 90, 20 41, 11 66, 13 0.0428 0.152 0.778 0.109 1.04 0.752 1.37 0.0392 0.477 0.935 0.029 1.04 0.419 2.75 0.371 0.547 0.498 0.303 1.45 0.515 4.27 -0.148 0.501 0.769 0.114 0.863 0.326 2.35 PRS_PLINK_1.99526231496888e.08 FALSE 159 Malignant neoplasm of other and ill-defined sites within the digestive organs and peritoneum Both 40 267 2 neoplasms darkcyan 267, 40 45, 6 92, 16 42, 7 66, 6 -0.14 0.179 0.434 0.362 0.869 0.552 1.16 0.0634 0.512 0.901 0.045 1.07 0.394 3.12 0.346 0.603 0.567 0.247 1.41 0.426 4.77 -0.0872 0.571 0.879 0.056 0.916 0.287 2.97 PRS_PLINK_1.99526231496888e.08 TRUE 159.2 Malignant neoplasm of small intestine, including duodenum Both 5 32 2 neoplasms darkcyan 32, 5 3, 1 8, 1 8, 2 8, 1 0.261 0.561 0.641 0.193 1.3 0.453 4.22 -1.82 2.33 0.433 0.364 0.161 0.134 4.26 -0.159 2.24 0.943 0.025 0.853 0.0406 1.07 1.79 3.12 0.565 0.248 6.01 0.0838 7.14 PRS_PLINK_1.99526231496888e.08 TRUE 159.3 Malignant neoplasm of gallbladder and extrahepatic bile ducts Both 2 13 2 neoplasms darkcyan 13, 2 2, 1 3, 1 3, 0 3, 0 -1.06 1.24 0.392 0.407 0.345 0.0169 2.75 -0.0197 7250000 1 0 0.98 0.00092 589 0.385 1420 1 0 1.47 0.103 15.5 -0.0163 1950 1 0 0.984 0.675 2.26 PRS_PLINK_1.99526231496888e.08 TRUE 159.4 Malignant neoplasm of retroperitoneum and peritoneum Both 7 62 2 neoplasms darkcyan 62, 7 11, 2 15, 3 15, 1 16, 0 -0.37 0.494 0.454 0.343 0.691 0.234 1.85 0.583 1.08 0.591 0.229 1.79 0.262 21.7 -0.665 1.2 0.579 0.237 0.514 0.00569 5.99 -0.486 1.22 0.691 0.161 0.615 0.03 9.94 PRS_PLINK_1.99526231496888e.08 TRUE 164 Cancer of intrathoracic organs Both 4 36 2 neoplasms darkcyan 36, 4 7, 0 14, 0 3, 3 9, 0 0.47 0.758 0.535 0.272 1.6 0.325 9.91 -0.225 2.36 0.924 0.034 0.798 0.00644 48.9 PRS_PLINK_1.99526231496888e.08 TRUE 165 Cancer within the respiratory system Both 14 226 2 neoplasms darkcyan 226, 14 37, 1 69, 4 44, 1 55, 4 -0.346 0.317 0.276 0.56 0.708 0.361 1.38 0.319 0.825 0.699 0.155 1.38 0.258 12.5 -0.526 0.972 0.588 0.23 0.591 0.0463 6.36 0.341 0.87 0.695 0.158 1.41 0.236 15.1 PRS_PLINK_1.99526231496888e.08 TRUE 165.1 Cancer of bronchus; lung Both 12 181 2 neoplasms darkcyan 181, 12 28, 1 58, 3 32, 0 45, 4 -0.352 0.345 0.308 0.512 0.703 0.336 1.45 -0.113 0.91 0.901 0.045 0.893 0.127 8.96 -1.43 1.24 0.252 0.598 0.24 0.00199 5.71 0.239 0.839 0.776 0.11 1.27 0.232 10.8 PRS_PLINK_1.99526231496888e.08 TRUE 170 Cancer of bone and connective tissue Both 32 341 2 neoplasms darkcyan 341, 32 43, 2 114, 13 55, 7 84, 7 0.107 0.15 0.475 0.323 1.11 0.751 1.42 0.538 0.687 0.434 0.363 1.71 0.467 9.14 0.872 0.723 0.228 0.641 2.39 0.576 14 0.308 0.733 0.675 0.171 1.36 0.305 7.95 PRS_PLINK_1.99526231496888e.08 TRUE 170.1 Bone cancer Both 15 151 2 neoplasms darkcyan 151, 15 16, 2 53, 7 23, 1 37, 5 0.144 0.258 0.576 0.239 1.15 0.609 1.8 0.0645 0.921 0.944 0.025 1.07 0.19 8.5 0.246 1.19 0.835 0.078 1.28 0.0924 93 -0.163 0.875 0.852 0.07 0.849 0.143 5.6 PRS_PLINK_1.99526231496888e.08 TRUE 170.2 Cancer of connective tissue Both 22 236 2 neoplasms darkcyan 236, 22 24, 0 61, 4 61, 11 55, 4 0.252 0.273 0.355 0.45 1.29 0.745 2.3 0.541 1.23 0.66 0.18 1.72 0.162 192 1.99 1.32 0.132 0.88 7.33 0.879 936 1.81 1.44 0.209 0.68 6.12 0.438 8380 PRS_PLINK_1.99526231496888e.08 TRUE 172 Skin cancer Both 134 884 2 neoplasms darkcyan 884, 134 126, 20 281, 59 159, 19 218, 24 -0.156 0.122 0.2 0.699 0.855 0.666 1.08 0.126 0.294 0.668 0.175 1.13 0.645 2.05 -0.22 0.361 0.541 0.267 0.802 0.392 1.64 -0.542 0.34 0.11 0.958 0.581 0.295 1.14 PRS_PLINK_1.99526231496888e.08 FALSE 172.1 Melanomas of skin, dx or hx Both 88 712 2 neoplasms darkcyan 712, 88 108, 16 220, 33 131, 12 177, 20 -0.0412 0.143 0.773 0.112 0.96 0.715 1.26 -0.077 0.334 0.818 0.087 0.926 0.486 1.81 -0.399 0.408 0.328 0.484 0.671 0.292 1.5 -0.321 0.36 0.372 0.429 0.725 0.356 1.49 PRS_PLINK_1.99526231496888e.08 FALSE 172.11 Melanomas of skin Both 38 526 2 neoplasms darkcyan 526, 38 78, 6 170, 15 91, 5 132, 10 0.188 0.184 0.308 0.511 1.21 0.8 1.69 0.137 0.49 0.78 0.108 1.15 0.447 3.25 -0.196 0.578 0.734 0.134 0.822 0.233 2.76 0.0187 0.523 0.971 0.013 1.02 0.353 3.08 PRS_PLINK_1.99526231496888e.08 TRUE 172.2 Other non-epithelial cancer of skin Both 118 726 2 neoplasms darkcyan 726, 118 100, 14 233, 52 128, 17 182, 24 -0.135 0.134 0.312 0.506 0.873 0.668 1.13 0.259 0.332 0.435 0.361 1.3 0.687 2.56 0.0249 0.401 0.951 0.022 1.03 0.466 2.28 -0.274 0.374 0.464 0.333 0.761 0.364 1.62 PRS_PLINK_1.99526231496888e.08 FALSE 172.21 Basal cell carcinoma Both 71 441 2 neoplasms darkcyan 441, 71 66, 12 140, 30 81, 9 109, 12 -0.246 0.171 0.151 0.82 0.782 0.554 1.09 0.0976 0.374 0.794 0.1 1.1 0.538 2.37 -0.378 0.47 0.421 0.376 0.685 0.266 1.72 -0.723 0.449 0.107 0.97 0.486 0.196 1.18 PRS_PLINK_1.99526231496888e.08 FALSE 172.22 Squamous cell carcinoma Both 35 242 2 neoplasms darkcyan 242, 35 35, 4 85, 18 35, 4 61, 8 -0.0958 0.243 0.693 0.159 0.909 0.561 1.48 0.491 0.569 0.388 0.411 1.63 0.571 5.64 -0.144 0.729 0.844 0.074 0.866 0.19 4.03 -0.0825 0.598 0.89 0.051 0.921 0.283 3.3 PRS_PLINK_1.99526231496888e.08 TRUE 172.3 Carcinoma in situ of skin Both 28 213 2 neoplasms darkcyan 213, 28 34, 3 72, 15 34, 3 53, 6 0.0837 0.284 0.768 0.114 1.09 0.617 1.95 0.524 0.626 0.403 0.395 1.69 0.518 7 0.00185 0.81 0.998 0.001 1 0.167 5.83 -0.0668 0.696 0.924 0.035 0.935 0.23 4.35 PRS_PLINK_1.99526231496888e.08 TRUE 173 Neoplasm of uncertain behavior of skin Both 103 450 2 neoplasms darkcyan 450, 103 68, 18 133, 35 90, 23 112, 22 0.0992 0.104 0.342 0.466 1.1 0.89 1.34 -0.0318 0.332 0.924 0.034 0.969 0.51 1.88 -0.0664 0.355 0.852 0.07 0.936 0.469 1.89 -0.331 0.356 0.352 0.453 0.718 0.358 1.45 PRS_PLINK_1.99526231496888e.08 FALSE 174 Breast cancer Both 141 466 2 neoplasms darkcyan 466, 141 69, 24 162, 40 70, 25 117, 32 0.0218 0.111 0.845 0.073 1.02 0.808 1.25 -0.298 0.322 0.353 0.452 0.742 0.398 1.4 0.127 0.393 0.747 0.126 1.13 0.527 2.46 -0.166 0.341 0.628 0.202 0.847 0.437 1.66 PRS_PLINK_1.99526231496888e.08 FALSE 174.1 Breast cancer [female] Female 135 459 2 neoplasms darkcyan 459, 135 68, 23 156, 39 73, 23 115, 31 0.0321 0.113 0.776 0.11 1.03 0.813 1.27 -0.264 0.327 0.419 0.378 0.768 0.408 1.47 0.108 0.406 0.79 0.102 1.11 0.504 2.48 -0.136 0.349 0.697 0.156 0.873 0.443 1.74 PRS_PLINK_1.99526231496888e.08 FALSE 174.11 Malignant neoplasm of female breast Female 132 451 2 neoplasms darkcyan 451, 132 72, 23 149, 37 72, 23 113, 30 0.0288 0.115 0.803 0.095 1.03 0.805 1.27 -0.201 0.327 0.538 0.269 0.818 0.435 1.56 0.234 0.415 0.573 0.242 1.26 0.562 2.87 -0.151 0.351 0.667 0.176 0.86 0.434 1.71 PRS_PLINK_1.99526231496888e.08 FALSE 174.3 Neoplasm of uncertain behavior of breast Both 21 50 2 neoplasms darkcyan 50, 21 10, 4 11, 6 12, 3 13, 4 -0.463 0.413 0.262 0.582 0.629 0.276 1.34 -0.936 1.4 0.503 0.298 0.392 0.000177 4.96 -1.93 1.38 0.164 0.786 0.146 0.00222 1.58 -0.719 1.08 0.506 0.296 0.487 0.0819 3.51 PRS_PLINK_1.99526231496888e.08 TRUE 175 Acquired absence of breast Female 63 202 2 neoplasms darkcyan 202, 63 26, 6 50, 16 50, 19 51, 10 0.0822 0.129 0.523 0.282 1.09 0.839 1.38 0.434 0.622 0.485 0.314 1.54 0.485 5.42 0.775 0.566 0.171 0.766 2.17 0.767 6.96 -0.436 0.634 0.491 0.309 0.646 0.187 2.28 PRS_PLINK_1.99526231496888e.08 FALSE 180 Cervical cancer and dysplasia Female 104 319 2 neoplasms darkcyan 319, 104 38, 12 106, 33 54, 15 79, 29 -0.0876 0.143 0.54 0.268 0.916 0.691 1.21 -0.0559 0.398 0.888 0.051 0.946 0.442 2.1 -0.134 0.465 0.773 0.112 0.874 0.349 2.19 -0.00425 0.411 0.992 0.004 0.996 0.453 2.25 PRS_PLINK_1.99526231496888e.08 FALSE 180.1 Cervical cancer Female 14 103 2 neoplasms darkcyan 103, 14 12, 4 35, 3 16, 3 26, 2 -0.414 0.397 0.297 0.528 0.661 0.285 1.45 -1.1 0.907 0.224 0.65 0.332 0.0545 1.91 -0.679 1.02 0.505 0.297 0.507 0.0561 4.01 -1.73 1.19 0.144 0.841 0.177 0.00797 1.56 PRS_PLINK_1.99526231496888e.08 TRUE 180.3 Cervical intraepithelial neoplasia [CIN] [Cervical dysplasia] Female 97 281 2 neoplasms darkcyan 281, 97 35, 12 88, 31 51, 12 70, 27 -0.164 0.148 0.267 0.573 0.848 0.633 1.13 0.0348 0.407 0.932 0.031 1.04 0.479 2.32 -0.249 0.489 0.611 0.214 0.779 0.297 2.02 -0.155 0.429 0.717 0.144 0.856 0.373 2 PRS_PLINK_1.99526231496888e.08 FALSE 182 Malignant neoplasm of uterus Female 18 113 2 neoplasms darkcyan 113, 18 14, 3 29, 3 27, 5 28, 5 -0.188 0.358 0.601 0.221 0.829 0.397 1.77 -0.822 0.814 0.312 0.505 0.439 0.0776 2.34 -0.263 0.793 0.741 0.13 0.769 0.166 3.84 -0.391 0.832 0.639 0.195 0.677 0.0928 3.7 PRS_PLINK_1.99526231496888e.08 TRUE 184 Cancer of other female genital organs Female 60 324 2 neoplasms darkcyan 324, 60 50, 10 109, 21 54, 13 79, 11 0.051 0.17 0.765 0.116 1.05 0.741 1.45 0.0967 0.438 0.825 0.083 1.1 0.478 2.69 0.118 0.467 0.8 0.097 1.13 0.454 2.83 -0.185 0.495 0.709 0.149 0.831 0.313 2.24 PRS_PLINK_1.99526231496888e.08 FALSE 184.1 Malignant neoplasm of ovary and other uterine adnexa Female 23 152 2 neoplasms darkcyan 152, 23 24, 6 46, 7 31, 4 37, 4 -0.346 0.306 0.258 0.589 0.707 0.382 1.3 -0.284 0.654 0.664 0.178 0.753 0.215 2.81 -0.649 0.694 0.35 0.456 0.522 0.123 1.99 -0.36 0.702 0.608 0.216 0.698 0.171 2.82 PRS_PLINK_1.99526231496888e.08 TRUE 184.11 Malignant neoplasm of ovary Female 18 128 2 neoplasms darkcyan 128, 18 22, 4 33, 5 30, 3 32, 4 -0.288 0.343 0.401 0.396 0.75 0.377 1.48 0.251 0.789 0.751 0.125 1.28 0.284 6.67 -0.606 0.842 0.472 0.326 0.546 0.0836 2.9 0.0967 0.756 0.898 0.047 1.1 0.254 5.25 PRS_PLINK_1.99526231496888e.08 TRUE 184.2 Cancer of other female genital organs (excluding uterus and ovary) Female 40 165 2 neoplasms darkcyan 165, 40 22, 6 55, 13 26, 11 41, 7 0.179 0.189 0.344 0.463 1.2 0.836 1.73 -0.163 0.601 0.786 0.105 0.85 0.276 2.83 0.362 0.603 0.548 0.261 1.44 0.474 4.58 -0.132 0.728 0.857 0.067 0.877 0.216 3.81 PRS_PLINK_1.99526231496888e.08 TRUE 185 Cancer of prostate Male 22 68 2 neoplasms darkcyan 68, 22 14, 4 22, 6 12, 3 17, 6 -0.593 0.424 0.162 0.791 0.552 0.228 1.22 -0.724 0.945 0.443 0.353 0.485 0.0654 3 -0.377 1.25 0.763 0.118 0.686 0.0284 6.62 -1.01 1.11 0.366 0.437 0.366 0.0294 2.99 PRS_PLINK_1.99526231496888e.08 TRUE 187 Cancer of other male genital organs Male 9 32 2 neoplasms darkcyan 32, 9 5, 3 8, 0 8, 2 8, 2 0.128 0.322 0.692 0.16 1.14 0.646 2.26 -0.123 2.13 0.954 0.02 0.884 0.0342 106 -0.543 1.59 0.733 0.135 0.581 0.0196 10.8 -0.109 1.63 0.946 0.024 0.896 0.17 42.8 PRS_PLINK_1.99526231496888e.08 TRUE 187.1 Malignant neoplasm of unspecified male genital organ Male 2 8 2 neoplasms darkcyan 8, 2 1, 0 2, 1 2, 0 2, 1 0.12 1.04 0.908 0.042 1.13 1.03 1.37 -0.217 31400 1 0 0.805 0.537 2.05 0.697 6060 1 0 2.01 0.259 6.28 PRS_PLINK_1.99526231496888e.08 TRUE 187.2 Malignant neoplasm of testis Male 7 16 2 neoplasms darkcyan 16, 7 3, 2 4, 0 4, 1 4, 2 -0.0631 0.407 0.877 0.057 0.939 0.252 2.36 -3.98 75.1 0.958 0.019 0.0186 0.0145 0.0241 1.21 3.55 0.733 0.135 3.34 0.0112 537 0.466 3.33 0.889 0.051 1.59 0.005 402 PRS_PLINK_1.99526231496888e.08 TRUE 187.8 Neoplasm of uncertain behavior of male genital organs Male 1 5 2 neoplasms darkcyan 5, 1 0.0271 98.5 1 0 1.03 0.765 2.04 PRS_PLINK_1.99526231496888e.08 TRUE 189 Cancer of urinary organs (incl. kidney and bladder) Both 37 387 2 neoplasms darkcyan 387, 37 58, 8 134, 14 58, 1 97, 13 0.17 0.229 0.457 0.34 1.19 0.753 1.9 -0.278 0.456 0.542 0.266 0.757 0.31 1.95 -1.5 0.821 0.0667 1.176 0.222 0.0236 1.03 -0.244 0.478 0.61 0.215 0.784 0.305 2.08 PRS_PLINK_1.99526231496888e.08 TRUE 189.1 Cancer of kidney and renal pelvis Both 23 236 2 neoplasms darkcyan 236, 23 33, 4 77, 9 40, 0 59, 9 0.15 0.282 0.594 0.226 1.16 0.662 2.09 -0.254 0.616 0.68 0.167 0.776 0.227 2.93 -1.81 1.18 0.126 0.9 0.164 0.000201 1.55 0.225 0.636 0.724 0.14 1.25 0.37 4.72 PRS_PLINK_1.99526231496888e.08 TRUE 189.11 Malignant neoplasm of kidney, except pelvis Both 19 215 2 neoplasms darkcyan 215, 19 28, 1 72, 8 35, 0 54, 9 0.473 0.319 0.137 0.862 1.61 0.855 3.19 0.68 0.864 0.431 0.365 1.97 0.399 19.3 -1.11 1.13 0.328 0.484 0.331 0.00374 5.19 1.07 0.855 0.209 0.679 2.93 0.604 28 PRS_PLINK_1.99526231496888e.08 TRUE 189.12 Malignant neoplasm of renal pelvis Both 4 27 2 neoplasms darkcyan 27, 4 6, 1 7, 1 6, 0 7, 2 0.884 1.54 0.567 0.247 2.42 0.0272 421000 1.52 3.07 0.621 0.207 4.56 0.0462 609000 -0.781 2.67 0.77 0.114 0.458 0.00127 67.2 0.019 2 0.992 0.003 1.02 0.0146 447 PRS_PLINK_1.99526231496888e.08 TRUE 189.2 Cancer of bladder Both 18 212 2 neoplasms darkcyan 212, 18 32, 2 71, 10 33, 1 53, 5 0.219 0.32 0.493 0.307 1.24 0.658 2.45 0.728 0.713 0.307 0.513 2.07 0.552 11.1 -0.64 1.21 0.597 0.224 0.527 0.00178 10.9 -0.288 0.845 0.733 0.135 0.75 0.133 4.87 PRS_PLINK_1.99526231496888e.08 TRUE 189.21 Malignant neoplasm of bladder Both 13 186 2 neoplasms darkcyan 186, 13 29, 2 45, 7 46, 2 47, 2 -0.0565 0.347 0.871 0.06 0.945 0.459 1.98 0.665 0.739 0.368 0.434 1.94 0.478 10.9 0.505 1.14 0.657 0.182 1.66 0.119 48.6 -1.15 1.05 0.272 0.566 0.317 0.00897 2.86 PRS_PLINK_1.99526231496888e.08 TRUE 189.4 Malignant neoplasm of other urinary organs Both 7 82 2 neoplasms darkcyan 82, 7 16, 1 21, 2 19, 0 21, 4 0.565 0.516 0.274 0.562 1.76 0.646 6.41 0.999 1.34 0.456 0.341 2.71 0.198 465 -1.26 1.36 0.353 0.452 0.284 0.00701 9.46 -0.26 1.64 0.874 0.059 0.771 3.22e-05 7000 PRS_PLINK_1.99526231496888e.08 TRUE 190 Cancer of eye Both 2 13 2 neoplasms darkcyan 13, 2 3, 0 3, 2 3, 0 3, 0 -0.0735 1.45 0.96 0.018 0.929 0.04 27.3 0.316 1030 1 0 1.37 0.142 83.6 PRS_PLINK_1.99526231496888e.08 TRUE 191 Manlignant and unknown neoplasms of brain and nervous system Both 18 256 2 neoplasms darkcyan 256, 18 29, 5 86, 8 43, 1 63, 3 -0.253 0.304 0.406 0.391 0.777 0.413 1.45 -0.507 0.665 0.446 0.351 0.602 0.165 2.39 -1.5 0.876 0.0871 1.06 0.223 0.0219 1.23 -1.69 0.808 0.0363 1.441 0.184 0.0254 0.941 PRS_PLINK_1.99526231496888e.08 TRUE 191.1 Cancer of brain and nervous system Both 12 156 2 neoplasms darkcyan 156, 12 16, 4 58, 4 20, 1 39, 2 -0.0599 0.358 0.867 0.062 0.942 0.453 1.99 -0.934 0.803 0.245 0.611 0.393 0.0752 2 -1.99 1.43 0.165 0.783 0.136 5.94e-05 1.97 -1.21 0.911 0.185 0.733 0.299 0.0392 1.72 PRS_PLINK_1.99526231496888e.08 TRUE 191.11 Cancer of brain Both 9 131 2 neoplasms darkcyan 131, 9 15, 4 46, 2 19, 1 33, 1 -0.285 0.409 0.486 0.314 0.752 0.316 1.75 -1.04 0.893 0.246 0.608 0.355 0.049 2.03 -1.38 1.34 0.301 0.522 0.251 0.000995 3.31 -1.69 1.05 0.106 0.973 0.184 0.145 1.13 PRS_PLINK_1.99526231496888e.08 TRUE 193 Thyroid cancer Both 31 310 2 neoplasms darkcyan 310, 31 40, 7 95, 7 57, 6 78, 8 -0.134 0.216 0.537 0.27 0.875 0.548 1.32 -0.825 0.592 0.163 0.787 0.438 0.131 1.47 -0.693 0.593 0.243 0.615 0.5 0.149 1.59 -0.441 0.528 0.404 0.393 0.644 0.223 1.89 PRS_PLINK_1.99526231496888e.08 TRUE 194 Cancer of other endocrine glands Both 24 157 2 neoplasms darkcyan 157, 24 22, 2 40, 8 37, 8 39, 5 0.0037 0.288 0.99 0.004 1 0.57 1.79 0.77 0.859 0.37 0.431 2.16 0.441 15.1 0.61 0.848 0.472 0.327 1.84 0.38 11.7 0.575 0.807 0.476 0.322 1.78 0.383 12 PRS_PLINK_1.99526231496888e.08 TRUE 195 Cancer, suspected or other Both 362 752 2 neoplasms darkcyan 752, 362 104, 49 248, 127 129, 56 187, 91 -0.0123 0.0776 0.874 0.058 0.988 0.842 1.14 -0.129 0.227 0.569 0.245 0.879 0.565 1.37 -0.224 0.258 0.386 0.414 0.8 0.483 1.32 -0.0851 0.236 0.718 0.144 0.918 0.58 1.46 PRS_PLINK_1.99526231496888e.08 FALSE 195.1 Malignant neoplasm, other Both 358 753 2 neoplasms darkcyan 753, 358 105, 50 247, 124 129, 56 188, 90 -0.00683 0.0774 0.93 0.032 0.993 0.847 1.15 -0.146 0.226 0.518 0.286 0.864 0.556 1.35 -0.227 0.258 0.379 0.421 0.797 0.482 1.32 -0.102 0.235 0.664 0.178 0.903 0.571 1.43 PRS_PLINK_1.99526231496888e.08 FALSE 195.3 Malignant neoplasm of head, face, and neck Both 10 130 2 neoplasms darkcyan 130, 10 24, 2 39, 0 23, 2 33, 5 0.19 0.404 0.639 0.194 1.21 0.531 3.01 -2.81 1.44 0.0512 1.291 0.0599 3.48e-05 1.03 -1.29 1.13 0.254 0.595 0.274 0.0155 4.94 0.142 0.774 0.854 0.068 1.15 0.254 6.67 PRS_PLINK_1.99526231496888e.08 TRUE 196 Radiotherapy Both 89 355 2 neoplasms darkcyan 355, 89 54, 18 110, 21 67, 17 88, 23 0.0944 0.124 0.447 0.35 1.1 0.841 1.37 -0.53 0.39 0.174 0.76 0.588 0.273 1.27 -0.277 0.426 0.516 0.287 0.758 0.329 1.74 -0.0112 0.395 0.977 0.01 0.989 0.461 2.15 PRS_PLINK_1.99526231496888e.08 FALSE 197 Chemotherapy Both 144 652 2 neoplasms darkcyan 652, 144 89, 21 213, 43 113, 25 163, 36 0.148 0.0886 0.0951 1.022 1.16 0.973 1.37 -0.169 0.304 0.577 0.239 0.844 0.47 1.55 -0.191 0.337 0.571 0.244 0.826 0.426 1.61 -0.0323 0.312 0.918 0.037 0.968 0.528 1.81 PRS_PLINK_1.99526231496888e.08 FALSE 198 Secondary malignant neoplasm Both 113 650 2 neoplasms darkcyan 650, 113 92, 19 212, 31 109, 19 163, 30 0.0659 0.11 0.548 0.261 1.07 0.843 1.3 -0.328 0.328 0.317 0.499 0.72 0.381 1.39 -0.331 0.373 0.375 0.426 0.718 0.344 1.49 -0.101 0.333 0.761 0.119 0.904 0.473 1.75 PRS_PLINK_1.99526231496888e.08 FALSE 198.1 Secondary malignancy of lymph nodes Both 74 575 2 neoplasms darkcyan 575, 74 80, 14 186, 14 102, 13 143, 26 0.195 0.112 0.0814 1.089 1.22 0.977 1.51 -0.788 0.401 0.0491 1.309 0.455 0.205 1.01 -0.425 0.431 0.325 0.489 0.654 0.276 1.53 0.0382 0.363 0.916 0.038 1.04 0.514 2.16 PRS_PLINK_1.99526231496888e.08 FALSE 198.2 Secondary malignancy of respiratory organs Both 21 177 2 neoplasms darkcyan 177, 21 29, 5 50, 8 38, 4 44, 3 -0.132 0.291 0.651 0.186 0.876 0.49 1.58 -0.0382 0.623 0.951 0.022 0.963 0.292 3.38 -0.627 0.719 0.383 0.417 0.534 0.116 2.2 -1.21 0.756 0.109 0.964 0.297 0.0551 1.3 PRS_PLINK_1.99526231496888e.08 TRUE 198.3 Secondary malignant neoplasm of digestive systems Both 13 157 2 neoplasms darkcyan 157, 13 24, 3 52, 5 25, 1 39, 3 -0.154 0.344 0.655 0.184 0.858 0.424 1.75 -0.407 0.75 0.588 0.231 0.666 0.148 3.27 -0.589 0.915 0.52 0.284 0.555 0.0565 3.65 -0.578 0.788 0.464 0.334 0.561 0.0992 2.93 PRS_PLINK_1.99526231496888e.08 TRUE 198.4 Secondary malignant neoplasm of liver Both 18 121 2 neoplasms darkcyan 121, 18 18, 4 41, 6 18, 3 30, 4 0.0586 0.319 0.854 0.068 1.06 0.566 2.03 -0.345 0.708 0.627 0.203 0.708 0.172 3.09 -0.152 0.822 0.854 0.069 0.859 0.163 4.85 -0.833 0.823 0.312 0.506 0.435 0.082 2.33 PRS_PLINK_1.99526231496888e.08 TRUE 198.5 Secondary malignancy of brain/spine Both 13 110 2 neoplasms darkcyan 110, 13 15, 4 36, 4 17, 2 28, 2 -0.0459 0.369 0.901 0.045 0.955 0.452 2.04 -0.28 0.768 0.715 0.146 0.756 0.172 3.63 -1.23 1.25 0.326 0.486 0.293 0.00395 3.48 -1.07 1.03 0.299 0.524 0.342 0.0322 2.82 PRS_PLINK_1.99526231496888e.08 TRUE 198.6 Secondary malignancy of bone Both 21 131 2 neoplasms darkcyan 131, 21 23, 3 36, 9 28, 4 33, 4 -0.152 0.318 0.633 0.199 0.859 0.458 1.64 0.443 0.724 0.54 0.267 1.56 0.4 7.27 0.502 0.866 0.562 0.25 1.65 0.315 11.6 -0.0553 0.812 0.946 0.024 0.946 0.186 5.42 PRS_PLINK_1.99526231496888e.08 TRUE 198.7 Secondary malignant neoplasm of skin Both 13 52 2 neoplasms darkcyan 52, 13 6, 5 15, 3 12, 2 12, 2 -0.0572 0.409 0.889 0.051 0.944 0.424 2.1 -0.651 0.967 0.5 0.301 0.521 0.0885 2.9 -1.44 1.3 0.269 0.571 0.238 0.0141 0.278 -1.74 1.22 0.156 0.808 0.176 0.0117 1.42 PRS_PLINK_1.99526231496888e.08 TRUE 199 Neoplasm of uncertain behavior Both 228 736 2 neoplasms darkcyan 736, 228 102, 43 244, 81 124, 35 184, 55 -0.0142 0.0902 0.875 0.058 0.986 0.82 1.17 -0.353 0.238 0.138 0.86 0.703 0.443 1.12 -0.478 0.28 0.0877 1.057 0.62 0.357 1.07 -0.461 0.254 0.0694 1.159 0.63 0.384 1.03 PRS_PLINK_1.99526231496888e.08 FALSE 199.4 Neurofibromatosis Both 2 26 2 neoplasms darkcyan 26, 2 5, 0 9, 0 3, 1 7, 1 0.179 1.01 0.86 0.066 1.2 0.149 383 -0.0617 25.6 0.998 0.001 0.94 0.255 1 1.18 2.6 0.65 0.187 3.26 0.0726 789 PRS_PLINK_1.99526231496888e.08 TRUE 200 Myeloproliferative disease Both 39 239 2 neoplasms darkcyan 239, 39 38, 7 60, 9 59, 8 60, 10 -0.128 0.232 0.582 0.235 0.88 0.556 1.4 -0.0322 0.558 0.954 0.02 0.968 0.324 3.03 -0.328 0.555 0.555 0.256 0.721 0.238 2.24 0.0314 0.553 0.955 0.02 1.03 0.351 3.22 PRS_PLINK_1.99526231496888e.08 TRUE 200.1 Polycythemia vera Both 8 35 2 neoplasms darkcyan 35, 8 6, 3 9, 3 8, 1 9, 0 -2.36 1.18 0.0455 1.342 0.0945 8.66e-06 0.76 0.5 1.34 0.709 0.149 1.65 0.0934 78 -1.58 2.09 0.449 0.347 0.206 2.31e-08 6.14 -1.13 1.58 0.475 0.324 0.324 0.0139 4.76 PRS_PLINK_1.99526231496888e.08 TRUE 201 Hodgkin's disease Both 5 38 2 neoplasms darkcyan 38, 5 8, 2 8, 1 9, 0 10, 1 -0.829 0.565 0.142 0.847 0.437 0.126 1.21 -0.624 1.48 0.674 0.171 0.536 0.00487 7.1 -1.16 1.63 0.477 0.322 0.313 2.93e-05 4.96 -0.692 1.27 0.585 0.233 0.501 0.0415 10.5 PRS_PLINK_1.99526231496888e.08 TRUE 202 Cancer of other lymphoid, histiocytic tissue Both 50 327 2 neoplasms darkcyan 327, 50 43, 14 114, 11 49, 7 82, 13 -0.143 0.188 0.447 0.35 0.867 0.588 1.24 -1.12 0.44 0.0105 1.978 0.325 0.135 0.765 -0.85 0.516 0.0994 1.003 0.427 0.148 1.12 -0.574 0.447 0.199 0.702 0.563 0.234 1.35 PRS_PLINK_1.99526231496888e.08 TRUE 202.2 Non-Hodgkins lymphoma Both 45 280 2 neoplasms darkcyan 280, 45 38, 12 96, 9 50, 6 64, 13 -0.0403 0.209 0.847 0.072 0.961 0.636 1.46 -1.18 0.495 0.0177 1.752 0.309 0.114 0.811 -0.954 0.552 0.0839 1.076 0.385 0.121 1.1 -0.229 0.474 0.63 0.201 0.796 0.318 2.03 PRS_PLINK_1.99526231496888e.08 TRUE 202.21 Nodular lymphoma Both 34 162 2 neoplasms darkcyan 162, 34 24, 8 55, 5 24, 5 41, 11 -0.0167 0.252 0.947 0.024 0.983 0.599 1.62 -0.955 0.613 0.119 0.923 0.385 0.109 1.28 -0.496 0.687 0.471 0.327 0.609 0.154 2.17 0.0465 0.575 0.935 0.029 1.05 0.352 3.3 PRS_PLINK_1.99526231496888e.08 TRUE 202.22 Reticulosarcoma Both 0 27 2 neoplasms darkcyan 27, 0 3 7 6 7 PRS_PLINK_1.99526231496888e.08 TRUE 202.24 Large cell lymphoma Both 0 22 2 neoplasms darkcyan 22, 0 3 5 5 6 PRS_PLINK_1.99526231496888e.08 TRUE 204 Leukemia Both 25 130 2 neoplasms darkcyan 130, 25 22, 0 40, 13 24, 4 32, 6 0.246 0.205 0.229 0.64 1.28 0.907 2.07 2.53 1.27 0.0466 1.332 12.6 1.59 1610 1.74 1.16 0.132 0.878 5.7 0.624 581 2.27 1.32 0.0866 1.062 9.68 0.953 2130 PRS_PLINK_1.99526231496888e.08 TRUE 204.1 Lymphoid leukemia Both 7 33 2 neoplasms darkcyan 33, 7 7, 1 8, 3 8, 1 8, 2 0.594 0.679 0.382 0.418 1.81 0.554 8.99 1.3 1.68 0.44 0.357 3.65 0.168 797 -0.0537 1.74 0.975 0.011 0.948 0.00173 97 1.65 2.31 0.475 0.323 5.22 0.0504 36700 PRS_PLINK_1.99526231496888e.08 TRUE 204.11 Lymphoid leukemia, acute Both 7 18 2 neoplasms darkcyan 18, 7 2, 0 6, 3 2, 2 5, 2 0.758 0.711 0.286 0.543 2.13 0.68 12.4 0.483 2.58 0.852 0.07 1.62 0.0316 611 0.679 1270 1 0 1.97 0.0943 50.7 0.201 114 0.999 0.001 1.22 0.621 12.4 PRS_PLINK_1.99526231496888e.08 TRUE 204.12 Lymphoid leukemia, chronic Both 1 19 2 neoplasms darkcyan 19, 1 5, 0 5, 1 4, 0 5, 0 -0.227 1.66 0.891 0.05 0.797 0.000594 76.6 0.687 2.44 0.779 0.109 1.99 0.0245 452 PRS_PLINK_1.99526231496888e.08 TRUE 204.2 Myeloid leukemia Both 12 62 2 neoplasms darkcyan 62, 12 12, 0 15, 7 15, 1 16, 3 -0.029 0.42 0.945 0.025 0.971 0.432 2.29 3 1.83 0.1 0.999 20.1 0.963 2310000 0.231 1.72 0.893 0.049 1.26 0.00459 1550 0.494 1.32 0.709 0.149 1.64 0.0541 166 PRS_PLINK_1.99526231496888e.08 TRUE 204.21 Myeloid leukemia, acute Both 6 39 2 neoplasms darkcyan 39, 6 6, 0 10, 3 9, 1 10, 2 0.219 0.629 0.728 0.138 1.24 0.31 5.9 0.485 1.89 0.797 0.098 1.62 0.00359 787 0.8 1.75 0.647 0.189 2.23 0.0404 378 1.12 2.07 0.588 0.231 3.07 0.0247 1120 PRS_PLINK_1.99526231496888e.08 TRUE 204.22 Myeloid leukemia, chronic Both 3 14 2 neoplasms darkcyan 14, 3 4, 0 3, 1 3, 0 4, 1 -0.499 1.23 0.685 0.164 0.607 0.0374 5.61 0.254 412 1 0 1.29 0.000114 53300 0.0938 2.84 0.974 0.012 1.1 1.08 1.13 PRS_PLINK_1.99526231496888e.08 TRUE 204.4 Multiple myeloma Both 8 35 2 neoplasms darkcyan 35, 8 3, 0 13, 5 4, 0 9, 2 -0.0166 0.602 0.978 0.01 0.984 0.308 3.74 0.653 2.18 0.765 0.117 1.92 0.052 858 2.16 4.88 0.658 0.182 8.7 0.000386 2.65e+11 PRS_PLINK_1.99526231496888e.08 TRUE 208 Benign neoplasm of colon Both 397 838 2 neoplasms darkcyan 838, 397 125, 49 270, 148 146, 58 210, 100 -0.0584 0.0719 0.416 0.38 0.943 0.814 1.08 0.252 0.218 0.248 0.606 1.29 0.845 1.98 0.00883 0.251 0.972 0.012 1.01 0.619 1.65 0.147 0.226 0.516 0.288 1.16 0.748 1.8 PRS_PLINK_1.99526231496888e.08 FALSE 209 Neuroendocrine tumors Both 6 52 2 neoplasms darkcyan 52, 6 6, 1 13, 3 13, 0 13, 2 0.225 0.536 0.674 0.172 1.25 0.43 3.87 -0.941 1.93 0.626 0.203 0.39 0.00361 12.7 -1.01 2.13 0.637 0.196 0.365 0.000936 32.3 -0.207 2.06 0.92 0.036 0.813 0.017 29.1 PRS_PLINK_1.99526231496888e.08 TRUE 210 Benign neoplasm of lip, oral cavity, and pharynx Both 44 459 2 neoplasms darkcyan 459, 44 67, 8 160, 11 70, 11 114, 11 0.00124 0.146 0.993 0.003 1 0.697 1.28 -0.899 0.494 0.0689 1.162 0.407 0.147 1.13 -0.218 0.511 0.669 0.175 0.804 0.29 2.23 -0.331 0.484 0.494 0.306 0.718 0.27 1.95 PRS_PLINK_1.99526231496888e.08 TRUE 211 Benign neoplasm of other parts of digestive system Both 364 861 2 neoplasms darkcyan 861, 364 140, 63 273, 111 155, 59 213, 81 -0.0985 0.0697 0.158 0.802 0.906 0.785 1.03 -0.166 0.194 0.392 0.407 0.847 0.581 1.24 -0.114 0.22 0.605 0.218 0.892 0.581 1.37 -0.232 0.207 0.262 0.583 0.793 0.53 1.19 PRS_PLINK_1.99526231496888e.08 FALSE 212 Benign neoplasm of respiratory and intrathoracic organs Both 39 396 2 neoplasms darkcyan 396, 39 56, 3 109, 9 88, 9 99, 12 0.146 0.186 0.434 0.363 1.16 0.776 1.63 0.409 0.672 0.543 0.265 1.51 0.42 6.7 0.283 0.678 0.676 0.17 1.33 0.351 6.06 0.815 0.648 0.208 0.681 2.26 0.658 9.74 PRS_PLINK_1.99526231496888e.08 TRUE 213 Benign neoplasm of bone and articular cartilage Both 42 171 2 neoplasms darkcyan 171, 42 30, 4 54, 16 31, 5 43, 12 0.162 0.233 0.489 0.311 1.18 0.743 1.84 0.775 0.616 0.208 0.681 2.17 0.706 8.07 0.18 0.801 0.822 0.085 1.2 0.241 6.57 0.749 0.658 0.254 0.594 2.12 0.629 8.5 PRS_PLINK_1.99526231496888e.08 TRUE 214 Lipoma Both 81 340 2 neoplasms darkcyan 340, 81 50, 8 110, 31 59, 13 85, 20 -0.0268 0.13 0.837 0.078 0.974 0.728 1.23 0.407 0.437 0.352 0.453 1.5 0.663 3.7 0.207 0.495 0.675 0.17 1.23 0.471 3.33 0.311 0.457 0.495 0.305 1.37 0.571 3.48 PRS_PLINK_1.99526231496888e.08 FALSE 214.1 Lipoma of skin and subcutaneous tissue Both 46 216 2 neoplasms darkcyan 216, 46 31, 6 70, 17 38, 6 54, 11 -0.0786 0.189 0.678 0.169 0.924 0.599 1.3 -0.0298 0.545 0.956 0.019 0.971 0.342 2.97 -0.192 0.64 0.764 0.117 0.825 0.227 2.95 -0.0806 0.55 0.883 0.054 0.923 0.317 2.83 PRS_PLINK_1.99526231496888e.08 TRUE 215 Other benign neoplasm of connective and other soft tissue Both 183 983 2 neoplasms darkcyan 983, 183 137, 22 333, 69 160, 25 244, 50 0.0142 0.0831 0.864 0.064 1.01 0.85 1.18 0.259 0.275 0.345 0.462 1.3 0.767 2.26 -0.077 0.318 0.809 0.092 0.926 0.495 1.74 0.217 0.28 0.439 0.358 1.24 0.723 2.19 PRS_PLINK_1.99526231496888e.08 FALSE 216 Benign neoplasm of skin Both 593 664 2 neoplasms darkcyan 664, 593 95, 71 215, 220 112, 96 166, 149 0.0475 0.0585 0.417 0.38 1.05 0.937 1.18 0.275 0.198 0.164 0.786 1.32 0.897 1.94 0.122 0.218 0.578 0.238 1.13 0.741 1.72 0.189 0.201 0.345 0.463 1.21 0.82 1.79 PRS_PLINK_1.99526231496888e.08 FALSE 216.1 Screening for malignant neoplasms of the skin Both 20 35 2 neoplasms darkcyan 35, 20 5, 3 9, 1 8, 5 9, 8 0.109 0.409 0.79 0.102 1.11 0.532 2.37 -3.27 2.24 0.144 0.841 0.038 1.02e-05 1.09 -0.397 2.06 0.848 0.072 0.673 0.0201 22.6 -0.776 1.67 0.643 0.192 0.46 0.00889 6.32 PRS_PLINK_1.99526231496888e.08 TRUE 217 Vascular hamartomas and non-neoplastic nevi Both 88 281 2 neoplasms darkcyan 281, 88 41, 12 85, 29 55, 11 70, 27 0.0957 0.167 0.567 0.246 1.1 0.796 1.53 0.177 0.399 0.658 0.182 1.19 0.559 2.65 -0.327 0.502 0.515 0.288 0.721 0.271 1.92 0.246 0.414 0.553 0.257 1.28 0.583 2.91 PRS_PLINK_1.99526231496888e.08 FALSE 217.1 Nevus, non-neoplastic Both 82 257 2 neoplasms darkcyan 257, 82 35, 8 83, 30 47, 10 62, 25 0.122 0.172 0.479 0.32 1.13 0.81 1.58 0.531 0.461 0.249 0.604 1.7 0.717 4.41 0.327 0.601 0.586 0.232 1.39 0.447 4.61 0.583 0.491 0.235 0.629 1.79 0.715 4.84 PRS_PLINK_1.99526231496888e.08 FALSE 218 Benign neoplasm of uterus Female 470 408 2 neoplasms darkcyan 408, 470 57, 73 131, 153 69, 69 102, 130 -0.0538 0.0715 0.452 0.345 0.948 0.821 1.08 -0.116 0.226 0.608 0.216 0.89 0.573 1.38 -0.255 0.258 0.323 0.491 0.775 0.47 1.27 -0.0881 0.233 0.706 0.151 0.916 0.582 1.44 PRS_PLINK_1.99526231496888e.08 FALSE 218.1 Uterine leiomyoma Female 195 377 2 neoplasms darkcyan 377, 195 48, 25 122, 56 67, 36 93, 59 0.00191 0.0887 0.983 0.008 1 0.833 1.18 -0.0593 0.324 0.855 0.068 0.942 0.505 1.79 -0.0623 0.342 0.855 0.068 0.94 0.486 1.82 0.128 0.324 0.694 0.159 1.14 0.609 2.15 PRS_PLINK_1.99526231496888e.08 FALSE 218.2 Other benign neoplasm of uterus Female 397 405 2 neoplasms darkcyan 405, 397 54, 65 135, 137 68, 53 100, 104 -0.0736 0.0756 0.33 0.481 0.929 0.796 1.07 -0.206 0.235 0.38 0.42 0.814 0.515 1.28 -0.433 0.272 0.111 0.954 0.648 0.382 1.09 -0.234 0.246 0.342 0.466 0.792 0.491 1.27 PRS_PLINK_1.99526231496888e.08 FALSE 220 Benign neoplasm of ovary Female 79 198 2 neoplasms darkcyan 198, 79 25, 12 69, 26 28, 10 50, 19 -0.0966 0.179 0.589 0.23 0.908 0.641 1.29 -0.244 0.431 0.572 0.243 0.784 0.347 1.81 -0.232 0.561 0.679 0.168 0.793 0.27 2.31 -0.334 0.464 0.472 0.326 0.716 0.294 1.76 PRS_PLINK_1.99526231496888e.08 FALSE 221 Benign neoplasm of other female genital organs Female 152 329 2 neoplasms darkcyan 329, 152 45, 24 109, 52 56, 28 81, 32 -0.117 0.12 0.33 0.481 0.89 0.695 1.11 -0.122 0.322 0.703 0.153 0.885 0.478 1.66 -0.239 0.356 0.502 0.299 0.788 0.396 1.56 -0.385 0.344 0.263 0.581 0.681 0.35 1.32 PRS_PLINK_1.99526231496888e.08 FALSE 222 Benign neoplasm of male genital organs Male 29 91 2 neoplasms darkcyan 91, 29 16, 5 33, 6 13, 4 22, 9 0.000186 0.282 0.999 0 1 0.583 1.73 -0.244 0.693 0.724 0.14 0.783 0.207 3.07 -0.114 0.857 0.894 0.049 0.892 0.164 4.6 0.504 0.677 0.457 0.34 1.65 0.487 6.32 PRS_PLINK_1.99526231496888e.08 TRUE 223 Benign neoplasm of kidney and other urinary organs Both 20 114 2 neoplasms darkcyan 114, 20 18, 4 38, 6 18, 4 29, 5 0.588 0.249 0.0183 1.738 1.8 1.22 3.63 -0.521 0.768 0.498 0.303 0.594 0.128 2.78 0.187 0.887 0.833 0.079 1.21 0.211 6.81 -0.211 0.861 0.806 0.093 0.81 0.147 4.58 PRS_PLINK_1.99526231496888e.08 TRUE 224 Benign neoplasm of eye Both 34 128 2 neoplasms darkcyan 128, 34 25, 6 33, 7 30, 7 32, 10 -0.174 0.211 0.408 0.389 0.84 0.506 1.19 -0.216 0.745 0.772 0.112 0.806 0.177 3.43 -0.196 0.703 0.781 0.107 0.822 0.204 3.12 -0.114 0.724 0.874 0.058 0.892 0.202 3.7 PRS_PLINK_1.99526231496888e.08 TRUE 224.1 Benign neoplasm of eye, uveal Both 31 117 2 neoplasms darkcyan 117, 31 23, 5 33, 7 25, 6 28, 9 -0.146 0.203 0.472 0.326 0.864 0.528 1.21 -0.0477 0.731 0.948 0.023 0.953 0.225 4.23 0.0437 0.769 0.955 0.02 1.04 0.225 4.56 0.299 0.758 0.693 0.159 1.35 0.323 6.41 PRS_PLINK_1.99526231496888e.08 TRUE 225 Benign neoplasm of brain and other parts of nervous system Both 27 296 2 neoplasms darkcyan 296, 27 37, 4 98, 11 48, 2 74, 10 0.224 0.158 0.156 0.808 1.25 0.847 1.63 -0.25 0.626 0.69 0.161 0.779 0.232 2.96 -0.67 0.865 0.438 0.358 0.511 0.0324 6.76 0.225 0.625 0.718 0.144 1.25 0.377 4.82 PRS_PLINK_1.99526231496888e.08 TRUE 225.1 Benign neoplasm of brain, cranial nerves, meninges Both 16 236 2 neoplasms darkcyan 236, 16 20, 1 89, 8 29, 2 59, 5 0.208 0.181 0.25 0.602 1.23 0.692 1.63 -0.105 0.94 0.911 0.04 0.901 0.158 9.31 -0.0596 1.06 0.955 0.02 0.942 0.0765 17.3 0.394 1.07 0.712 0.147 1.48 0.196 24.9 PRS_PLINK_1.99526231496888e.08 TRUE 225.2 Benign neoplasm of spinal cord, meninges Both 11 78 2 neoplasms darkcyan 78, 11 13, 2 23, 4 15, 1 20, 4 0.842 0.509 0.0981 1.008 2.32 0.88 7.84 -0.183 0.983 0.853 0.069 0.833 0.121 6.45 -0.628 1.49 0.673 0.172 0.534 0.00494 23.5 0.845 1.06 0.427 0.369 2.33 0.357 39.8 PRS_PLINK_1.99526231496888e.08 TRUE 226 Benign neoplasm of thyroid glands Both 45 403 2 neoplasms darkcyan 403, 45 52, 6 131, 16 73, 11 98, 7 -0.0792 0.184 0.666 0.177 0.924 0.629 1.31 -0.0654 0.503 0.896 0.047 0.937 0.357 2.73 0.309 0.514 0.548 0.261 1.36 0.496 4.04 -0.323 0.538 0.549 0.26 0.724 0.239 2.25 PRS_PLINK_1.99526231496888e.08 TRUE 227 Benign neoplasm of other endocrine glands and related structures Both 66 432 2 neoplasms darkcyan 432, 66 62, 7 107, 19 106, 20 107, 16 0.0305 0.137 0.824 0.084 1.03 0.761 1.32 0.327 0.481 0.496 0.304 1.39 0.554 3.79 0.423 0.472 0.371 0.431 1.53 0.622 4.08 0.0435 0.517 0.933 0.03 1.04 0.384 3.04 PRS_PLINK_1.99526231496888e.08 FALSE 227.1 Benign neoplasm of adrenal gland Both 22 112 2 neoplasms darkcyan 112, 22 14, 1 34, 9 22, 3 28, 8 0.146 0.23 0.527 0.279 1.16 0.739 1.78 2.06 1.35 0.128 0.894 7.81 0.764 266 -1.66 1.5 0.27 0.569 0.191 3.16e-06 4.56 0.677 1.04 0.517 0.287 1.97 0.307 31.4 PRS_PLINK_1.99526231496888e.08 TRUE 227.2 Benign neoplasm of parathyroid gland Both 19 187 2 neoplasms darkcyan 187, 19 23, 2 67, 9 26, 2 47, 4 -0.158 0.297 0.595 0.225 0.854 0.468 1.57 -0.0353 0.844 0.967 0.015 0.965 0.202 6.45 -0.625 0.971 0.52 0.284 0.535 0.0153 4.04 -0.476 0.874 0.586 0.232 0.621 0.098 4.13 PRS_PLINK_1.99526231496888e.08 TRUE 227.3 Benign neoplasm of pituitary gland and craniopharyngeal duct (pouch) Both 29 128 2 neoplasms darkcyan 128, 29 15, 3 36, 8 28, 11 32, 6 0.034 0.185 0.854 0.068 1.03 0.661 1.41 0.14 0.76 0.854 0.069 1.15 0.29 5.42 0.363 0.785 0.644 0.191 1.44 0.347 7.06 0.271 0.869 0.755 0.122 1.31 0.262 7.52 PRS_PLINK_1.99526231496888e.08 TRUE 228 Hemangioma and lymphangioma, any site Both 99 506 2 neoplasms darkcyan 506, 99 78, 15 165, 29 87, 18 127, 23 -0.147 0.13 0.26 0.586 0.863 0.653 1.1 -0.0131 0.357 0.971 0.013 0.987 0.495 2.03 0.212 0.405 0.601 0.221 1.24 0.563 2.77 -0.0708 0.368 0.847 0.072 0.932 0.455 1.95 PRS_PLINK_1.99526231496888e.08 FALSE 228.1 Hemangioma of skin and subcutaneous tissue Both 76 300 2 neoplasms darkcyan 300, 76 46, 8 90, 24 60, 15 75, 16 -0.211 0.155 0.175 0.757 0.81 0.581 1.08 0.47 0.457 0.303 0.519 1.6 0.673 4.13 0.563 0.521 0.281 0.552 1.76 0.653 5.07 0.205 0.471 0.663 0.178 1.23 0.5 3.23 PRS_PLINK_1.99526231496888e.08 FALSE 229 Benign neoplasm of unspecified sites Both 171 1003 2 neoplasms darkcyan 1003, 171 146, 23 334, 59 166, 31 248, 39 0.00816 0.0894 0.927 0.033 1.01 0.835 1.19 0.2 0.272 0.463 0.335 1.22 0.724 2.12 0.143 0.299 0.631 0.2 1.15 0.642 2.1 -0.042 0.287 0.884 0.054 0.959 0.547 1.71 PRS_PLINK_1.99526231496888e.08 FALSE 229.1 Benign neoplasm of lymph nodes Both 96 928 2 neoplasms darkcyan 928, 96 142, 13 303, 33 158, 15 228, 21 -0.106 0.125 0.394 0.404 0.899 0.69 1.14 0.271 0.344 0.432 0.365 1.31 0.676 2.69 0.036 0.379 0.924 0.034 1.04 0.482 2.26 -0.00122 0.359 0.997 0.001 0.999 0.491 2.1 PRS_PLINK_1.99526231496888e.08 FALSE 240 Simple and unspecified goiter Both 74 340 3 endocrine/metabolic brown 340, 74 51, 16 113, 19 56, 17 85, 14 0.023 0.109 0.833 0.079 1.02 0.816 1.25 -0.698 0.392 0.0751 1.124 0.498 0.231 1.07 -0.0986 0.407 0.809 0.092 0.906 0.411 1.99 -0.641 0.415 0.123 0.911 0.527 0.231 1.18 PRS_PLINK_1.99526231496888e.08 FALSE 241 Nontoxic nodular goiter Both 135 676 3 endocrine/metabolic brown 676, 135 103, 33 225, 33 110, 29 169, 25 -0.112 0.111 0.312 0.505 0.894 0.707 1.1 -0.952 0.287 0.000901 3.045 0.386 0.219 0.676 -0.239 0.297 0.422 0.375 0.788 0.44 1.4 -0.921 0.306 0.00259 2.586 0.398 0.216 0.721 PRS_PLINK_1.99526231496888e.08 FALSE 241.1 Nontoxic uninodular goiter Both 111 588 3 endocrine/metabolic brown 588, 111 91, 21 202, 29 90, 24 147, 25 -0.000896 0.118 0.994 0.003 0.999 0.782 1.24 -0.583 0.323 0.0715 1.145 0.558 0.295 1.06 0.0618 0.338 0.855 0.068 1.06 0.549 2.07 -0.439 0.333 0.187 0.728 0.644 0.334 1.24 PRS_PLINK_1.99526231496888e.08 FALSE 241.2 Nontoxic multinodular goiter Both 62 373 3 endocrine/metabolic brown 373, 62 58, 13 123, 17 63, 11 93, 12 -0.111 0.161 0.49 0.31 0.895 0.633 1.2 -0.7 0.422 0.0971 1.013 0.497 0.215 1.15 -0.155 0.445 0.727 0.138 0.856 0.354 2.06 -0.84 0.456 0.0656 1.183 0.432 0.171 1.05 PRS_PLINK_1.99526231496888e.08 FALSE 242 Thyrotoxicosis with or without goiter Both 73 400 3 endocrine/metabolic brown 400, 73 58, 13 136, 19 64, 13 100, 24 0.0968 0.127 0.445 0.351 1.1 0.845 1.39 -0.503 0.392 0.199 0.701 0.605 0.281 1.33 0.0274 0.452 0.952 0.021 1.03 0.423 2.5 0.0295 0.386 0.939 0.027 1.03 0.49 2.23 PRS_PLINK_1.99526231496888e.08 FALSE 242.1 Graves' disease Both 26 172 3 endocrine/metabolic brown 172, 26 24, 5 56, 7 30, 4 43, 9 0.0779 0.161 0.628 0.202 1.08 0.675 1.39 -0.79 0.646 0.221 0.655 0.454 0.124 1.65 -0.37 0.742 0.618 0.209 0.69 0.149 2.99 -0.542 0.662 0.413 0.384 0.582 0.157 2.12 PRS_PLINK_1.99526231496888e.08 TRUE 242.2 Toxic multinodular goiter Both 12 30 3 endocrine/metabolic brown 30, 12 4, 5 8, 2 6, 1 8, 3 0.152 0.763 0.842 0.075 1.16 0.29 5.01 -2.27 1.67 0.173 0.761 0.103 1.49e-05 1.29 -0.901 1.72 0.6 0.222 0.406 0.00349 7.37 -1.92 1.59 0.227 0.645 0.146 0.00268 1.6 PRS_PLINK_1.99526231496888e.08 TRUE 242.3 Exophthalmos Both 10 78 3 endocrine/metabolic brown 78, 10 16, 3 22, 1 16, 3 20, 3 0.157 0.201 0.436 0.361 1.17 0.511 1.61 -2.52 1.58 0.111 0.953 0.0806 8.97e-05 1.57 -0.336 1.12 0.764 0.117 0.715 0.0347 14.1 -0.544 1.15 0.636 0.196 0.58 0.0424 5.54 PRS_PLINK_1.99526231496888e.08 TRUE 242.31 Thyrotoxic exophthalmos Both 6 47 3 endocrine/metabolic brown 47, 6 7, 1 17, 1 6, 1 12, 3 0.00587 0.631 0.993 0.003 1.01 0.241 4.56 -0.993 1.48 0.502 0.299 0.37 0.00356 6.4 -0.674 1.79 0.706 0.151 0.51 0.000326 51.4 -0.371 1.33 0.78 0.108 0.69 0.00013 9.01 PRS_PLINK_1.99526231496888e.08 TRUE 244 Hypothyroidism Both 309 810 3 endocrine/metabolic brown 810, 309 121, 51 274, 89 128, 51 201, 86 0.0786 0.0657 0.232 0.635 1.08 0.952 1.23 -0.251 0.218 0.249 0.603 0.778 0.51 1.19 -0.088 0.248 0.723 0.141 0.916 0.565 1.48 0.0362 0.221 0.87 0.061 1.04 0.677 1.6 PRS_PLINK_1.99526231496888e.08 FALSE 244.1 Secondary hypothyroidism Both 65 488 3 endocrine/metabolic brown 488, 65 77, 12 165, 12 78, 13 120, 21 0.116 0.116 0.318 0.498 1.12 0.863 1.37 -0.686 0.451 0.128 0.893 0.504 0.204 1.25 -0.042 0.446 0.925 0.034 0.959 0.397 2.32 0.185 0.401 0.645 0.191 1.2 0.554 2.71 PRS_PLINK_1.99526231496888e.08 FALSE 244.2 Acquired hypothyroidism Both 96 357 3 endocrine/metabolic brown 357, 96 48, 18 117, 27 61, 13 89, 27 0.0237 0.0962 0.805 0.094 1.02 0.834 1.22 -0.429 0.365 0.239 0.621 0.651 0.323 1.33 -0.556 0.417 0.183 0.738 0.574 0.251 1.28 -0.238 0.363 0.512 0.291 0.789 0.393 1.6 PRS_PLINK_1.99526231496888e.08 FALSE 244.4 Hypothyroidism NOS Both 293 803 3 endocrine/metabolic brown 803, 293 120, 48 274, 86 123, 46 200, 83 0.0753 0.0666 0.259 0.587 1.08 0.947 1.23 -0.226 0.222 0.309 0.511 0.797 0.519 1.23 -0.12 0.258 0.643 0.192 0.887 0.537 1.46 0.0396 0.225 0.86 0.065 1.04 0.674 1.62 PRS_PLINK_1.99526231496888e.08 FALSE 245 Thyroiditis Both 61 305 3 endocrine/metabolic brown 305, 61 37, 8 104, 17 49, 14 75, 12 -0.0748 0.141 0.595 0.225 0.928 0.682 1.19 -0.425 0.491 0.387 0.413 0.654 0.253 1.77 0.17 0.492 0.73 0.137 1.19 0.464 3.17 -0.241 0.485 0.619 0.208 0.786 0.304 2.11 PRS_PLINK_1.99526231496888e.08 FALSE 245.2 Chronic thyroiditis Both 50 271 3 endocrine/metabolic brown 271, 50 29, 7 96, 13 40, 7 67, 14 -0.0047 0.154 0.976 0.011 0.995 0.719 1.32 -0.76 0.553 0.169 0.772 0.468 0.158 1.42 -0.419 0.579 0.47 0.328 0.658 0.208 2.02 -0.0976 0.52 0.851 0.07 0.907 0.335 2.6 PRS_PLINK_1.99526231496888e.08 TRUE 245.21 Chronic lymphocytic thyroiditis Both 50 266 3 endocrine/metabolic brown 266, 50 30, 7 96, 13 36, 7 67, 14 -0.0183 0.138 0.895 0.048 0.982 0.709 1.24 -0.781 0.55 0.156 0.807 0.458 0.156 1.39 -0.192 0.564 0.733 0.135 0.825 0.275 2.46 -0.137 0.518 0.792 0.101 0.872 0.324 2.49 PRS_PLINK_1.99526231496888e.08 TRUE 246 Other disorders of thyroid Both 218 777 3 endocrine/metabolic brown 777, 218 115, 32 263, 73 122, 38 194, 53 0.0872 0.0732 0.234 0.631 1.09 0.943 1.25 -0.0256 0.248 0.918 0.037 0.975 0.604 1.6 0.0326 0.29 0.91 0.041 1.03 0.587 1.82 -0.0349 0.258 0.893 0.049 0.966 0.586 1.61 PRS_PLINK_1.99526231496888e.08 FALSE 246.2 Thyroid cyst Both 4 27 3 endocrine/metabolic brown 27, 4 3, 0 7, 1 6, 1 7, 1 0.147 0.471 0.755 0.122 1.16 0.418 6.55 4.3 5.82 0.459 0.338 74 0.039 24500000 1.33 301 0.996 0.002 3.77 0.00267 11600 -0.554 8.86 0.95 0.022 0.574 1.12e-07 433000 PRS_PLINK_1.99526231496888e.08 TRUE 246.7 Abnormal results of function study of thyroid Both 53 246 3 endocrine/metabolic brown 246, 53 37, 10 88, 13 33, 9 62, 15 -0.0197 0.132 0.881 0.055 0.98 0.711 1.22 -0.576 0.472 0.222 0.654 0.562 0.224 1.44 0.0666 0.524 0.899 0.046 1.07 0.389 2.91 -0.0949 0.462 0.837 0.077 0.909 0.373 2.28 PRS_PLINK_1.99526231496888e.08 FALSE 249 Secondary diabetes mellitus Both 43 102 3 endocrine/metabolic brown 102, 43 20, 5 29, 16 21, 8 26, 10 -0.0126 0.194 0.948 0.023 0.988 0.709 1.5 0.472 0.617 0.444 0.353 1.6 0.522 5.39 0.39 0.693 0.573 0.242 1.48 0.415 5.62 -0.128 0.69 0.853 0.069 0.88 0.234 3.27 PRS_PLINK_1.99526231496888e.08 TRUE 250 Diabetes mellitus Both 501 759 3 endocrine/metabolic brown 759, 501 108, 70 243, 183 139, 78 187, 119 -0.0618 0.0693 0.373 0.428 0.94 0.819 1.07 0.065 0.212 0.759 0.119 1.07 0.707 1.62 -0.229 0.241 0.342 0.465 0.796 0.497 1.27 -0.0633 0.218 0.772 0.113 0.939 0.614 1.44 PRS_PLINK_1.99526231496888e.08 FALSE 250.1 Type 1 diabetes Both 115 185 3 endocrine/metabolic brown 185, 115 30, 15 60, 44 32, 15 46, 32 0.0451 0.18 0.802 0.096 1.05 0.765 1.56 0.472 0.473 0.319 0.497 1.6 0.656 4.18 -0.211 0.655 0.747 0.126 0.81 0.204 3.05 0.374 0.537 0.486 0.313 1.45 0.516 4.31 PRS_PLINK_1.99526231496888e.08 FALSE 250.11 Type 1 diabetes with ketoacidosis Both 21 21 3 endocrine/metabolic brown 21, 21 4, 2 6, 5 4, 5 5, 6 -0.162 0.524 0.757 0.121 0.85 0.316 2.18 0.00742 151 1 0 1.01 0.845 1.57 0.153 1.98 0.938 0.028 1.17 0.00459 526 -1.1 2.21 0.619 0.208 0.333 0.000589 144 PRS_PLINK_1.99526231496888e.08 TRUE 250.12 Type 1 diabetes with renal manifestations Both 25 53 3 endocrine/metabolic brown 53, 25 11, 5 21, 8 5, 2 13, 7 -0.0339 0.43 0.937 0.028 0.967 0.417 2.2 -0.321 0.844 0.704 0.153 0.725 0.128 3.69 0.374 1.86 0.84 0.076 1.45 0.00262 3640 -0.0265 1.06 0.98 0.009 0.974 0.122 8.11 PRS_PLINK_1.99526231496888e.08 TRUE 250.13 Type 1 diabetes with ophthalmic manifestations Both 44 67 3 endocrine/metabolic brown 67, 44 13, 8 21, 14 13, 4 16, 15 0.0265 0.199 0.894 0.049 1.03 0.754 1.74 0.146 0.668 0.828 0.082 1.16 0.332 4.25 0.000171 1.08 1 0 1 0.129 11.5 -0.105 0.943 0.912 0.04 0.901 0.106 6.98 PRS_PLINK_1.99526231496888e.08 TRUE 250.14 Type 1 diabetes with neurological manifestations Both 33 54 3 endocrine/metabolic brown 54, 33 10, 7 18, 12 8, 3 14, 9 0.0679 0.412 0.869 0.061 1.07 0.492 2.38 0.347 0.857 0.686 0.164 1.41 0.288 7.87 -0.112 1.23 0.927 0.033 0.894 0.00292 28.5 0.528 1.07 0.622 0.206 1.7 0.242 20 PRS_PLINK_1.99526231496888e.08 TRUE 250.15 Diabetes type 1 with peripheral circulatory disorders Both 8 12 3 endocrine/metabolic brown 12, 8 3, 1 3, 1 3, 1 3, 4 -2.04 1.63 0.212 0.673 0.13 0.102 1.36 -0.0691 3020 1 0 0.933 0.916 1.65 0.308 1600 1 0 1.36 0.0547 5.94 -0.341 1.9 0.858 0.067 0.711 0.0307 10.8 PRS_PLINK_1.99526231496888e.08 TRUE 250.2 Type 2 diabetes Both 297 687 3 endocrine/metabolic brown 687, 297 101, 45 214, 108 132, 43 168, 70 -0.103 0.0887 0.248 0.606 0.903 0.758 1.07 0.171 0.262 0.514 0.289 1.19 0.717 1.99 -0.275 0.309 0.374 0.427 0.76 0.413 1.39 -0.00452 0.276 0.987 0.006 0.995 0.582 1.72 PRS_PLINK_1.99526231496888e.08 FALSE 250.21 Type 2 diabetes with ketoacidosis Both 24 30 3 endocrine/metabolic brown 30, 24 5, 3 8, 7 7, 1 7, 12 -0.0719 0.478 0.881 0.055 0.931 0.365 2.27 0.407 1.13 0.718 0.144 1.5 0.211 12.9 -0.63 1.82 0.73 0.137 0.533 0.00399 27.3 0.322 1.19 0.787 0.104 1.38 0.143 18.4 PRS_PLINK_1.99526231496888e.08 TRUE 250.22 Type 2 diabetes with renal manifestations Both 61 154 3 endocrine/metabolic brown 154, 61 27, 7 45, 25 30, 9 39, 15 0.0143 0.175 0.935 0.029 1.01 0.739 1.45 0.62 0.577 0.283 0.549 1.86 0.63 6.01 0.25 0.732 0.733 0.135 1.28 0.299 6.01 0.356 0.63 0.573 0.242 1.43 0.43 5.21 PRS_PLINK_1.99526231496888e.08 FALSE 250.23 Type 2 diabetes with ophthalmic manifestations Both 79 122 3 endocrine/metabolic brown 122, 79 17, 10 34, 27 27, 14 30, 22 -0.00647 0.223 0.977 0.01 0.994 0.643 1.54 0.524 0.596 0.38 0.421 1.69 0.552 5.64 0.373 0.756 0.622 0.206 1.45 0.34 7.41 0.0929 0.65 0.886 0.052 1.1 0.315 4.05 PRS_PLINK_1.99526231496888e.08 FALSE 250.24 Type 2 diabetes with neurological manifestations Both 91 211 3 endocrine/metabolic brown 211, 91 36, 16 68, 36 38, 12 52, 19 -0.0624 0.138 0.651 0.186 0.94 0.722 1.23 0.176 0.468 0.707 0.151 1.19 0.486 3.05 0.068 0.577 0.906 0.043 1.07 0.347 3.44 -0.123 0.536 0.819 0.087 0.885 0.309 2.58 PRS_PLINK_1.99526231496888e.08 FALSE 250.25 Diabetes type 2 with peripheral circulatory disorders Both 23 50 3 endocrine/metabolic brown 50, 23 8, 3 17, 9 7, 3 13, 5 -0.126 0.285 0.658 0.182 0.881 0.394 1.35 0.364 0.896 0.685 0.165 1.44 0.301 8.42 0.278 1.41 0.844 0.074 1.32 0.1 20.6 -1.43 1.26 0.257 0.589 0.239 0.00719 1.97 PRS_PLINK_1.99526231496888e.08 TRUE 250.3 Insulin pump user Both 140 338 3 endocrine/metabolic brown 338, 140 55, 18 100, 51 66, 22 84, 37 -0.0347 0.118 0.77 0.114 0.966 0.775 1.23 0.46 0.392 0.242 0.617 1.58 0.749 3.52 0.0759 0.483 0.875 0.058 1.08 0.411 2.92 0.186 0.437 0.669 0.174 1.2 0.518 2.9 PRS_PLINK_1.99526231496888e.08 FALSE 250.4 Abnormal glucose Both 413 730 3 endocrine/metabolic brown 730, 413 109, 67 226, 144 137, 63 179, 99 -0.0552 0.0721 0.445 0.352 0.946 0.819 1.09 0.0148 0.218 0.946 0.024 1.01 0.665 1.56 -0.289 0.245 0.238 0.623 0.749 0.464 1.21 -0.12 0.225 0.594 0.226 0.887 0.573 1.38 PRS_PLINK_1.99526231496888e.08 FALSE 250.41 Impaired fasting glucose Both 105 311 3 endocrine/metabolic brown 311, 105 47, 13 100, 37 53, 11 78, 35 0.174 0.156 0.265 0.576 1.19 0.88 1.62 0.339 0.401 0.398 0.401 1.4 0.66 3.14 -0.202 0.467 0.665 0.177 0.817 0.326 2.03 0.361 0.4 0.367 0.436 1.43 0.669 3.18 PRS_PLINK_1.99526231496888e.08 FALSE 250.42 Other abnormal glucose Both 361 707 3 endocrine/metabolic brown 707, 361 98, 55 225, 132 128, 54 177, 88 -0.0428 0.0751 0.568 0.245 0.958 0.824 1.11 0.0137 0.235 0.953 0.021 1.01 0.644 1.61 -0.315 0.269 0.242 0.616 0.73 0.431 1.23 -0.147 0.244 0.547 0.262 0.863 0.537 1.39 PRS_PLINK_1.99526231496888e.08 FALSE 250.5 Glycosuria or Acetonuria Both 6 36 3 endocrine/metabolic brown 36, 6 4, 0 10, 2 8, 2 9, 1 -0.467 0.859 0.587 0.232 0.627 0.00461 3.49 -0.0872 2.12 0.967 0.014 0.916 0.00297 399 -0.0601 1.92 0.975 0.011 0.942 0.0278 199 0.547 2.26 0.809 0.092 1.73 0.00646 425 PRS_PLINK_1.99526231496888e.08 TRUE 250.6 Polyneuropathy in diabetes Both 79 166 3 endocrine/metabolic brown 166, 79 32, 13 44, 30 34, 11 42, 18 0.00411 0.165 0.98 0.009 1 0.742 1.41 0.373 0.498 0.455 0.342 1.45 0.558 3.91 0.287 0.612 0.639 0.194 1.33 0.411 4.63 -0.249 0.61 0.683 0.165 0.78 0.224 2.61 PRS_PLINK_1.99526231496888e.08 FALSE 250.7 Diabetic retinopathy Both 81 174 3 endocrine/metabolic brown 174, 81 22, 11 59, 29 27, 11 44, 24 0.0469 0.164 0.775 0.111 1.05 0.753 1.42 -0.0807 0.466 0.863 0.064 0.922 0.383 2.28 -0.297 0.584 0.612 0.213 0.743 0.242 2.23 0.286 0.537 0.595 0.226 1.33 0.484 3.85 PRS_PLINK_1.99526231496888e.08 FALSE 251 Other disorders of pancreatic internal secretion Both 52 159 3 endocrine/metabolic brown 159, 52 23, 6 49, 18 30, 11 40, 14 -0.0134 0.161 0.934 0.03 0.987 0.694 1.31 0.198 0.536 0.712 0.148 1.22 0.456 3.57 0.307 0.68 0.652 0.186 1.36 0.391 5.16 0.245 0.584 0.675 0.171 1.28 0.437 4.1 PRS_PLINK_1.99526231496888e.08 FALSE 251.1 Hypoglycemia Both 66 154 3 endocrine/metabolic brown 154, 66 22, 9 49, 24 27, 9 39, 18 -0.0561 0.182 0.758 0.12 0.945 0.64 1.3 0.303 0.538 0.573 0.242 1.35 0.498 3.9 -0.539 0.755 0.475 0.323 0.583 0.118 2.52 0.475 0.601 0.429 0.367 1.61 0.528 5.21 PRS_PLINK_1.99526231496888e.08 FALSE 252 Disorders of parathyroid gland Both 83 371 3 endocrine/metabolic brown 371, 83 60, 10 120, 27 66, 14 92, 23 -0.0281 0.142 0.844 0.074 0.972 0.72 1.26 0.356 0.413 0.388 0.411 1.43 0.653 3.33 0.221 0.458 0.628 0.202 1.25 0.51 3.12 0.341 0.431 0.428 0.368 1.41 0.617 3.38 PRS_PLINK_1.99526231496888e.08 FALSE 252.1 Hyperparathyroidism Both 75 333 3 endocrine/metabolic brown 333, 75 53, 8 102, 27 65, 14 82, 17 -0.0967 0.151 0.522 0.282 0.908 0.661 1.2 0.628 0.443 0.157 0.805 1.87 0.816 4.72 0.343 0.489 0.483 0.316 1.41 0.545 3.83 0.29 0.468 0.535 0.272 1.34 0.547 3.49 PRS_PLINK_1.99526231496888e.08 FALSE 252.2 Hypoparathyroidism Both 17 85 3 endocrine/metabolic brown 85, 17 16, 2 29, 8 13, 1 21, 5 0.294 0.378 0.437 0.36 1.34 0.652 2.85 1.04 0.938 0.266 0.575 2.84 0.511 27.8 1.34 1.45 0.354 0.451 3.83 0.208 433 0.639 0.889 0.472 0.326 1.89 0.37 11.9 PRS_PLINK_1.99526231496888e.08 TRUE 253 Disorders of the pituitary gland and its hypothalamic control Both 84 146 3 endocrine/metabolic brown 146, 84 17, 9 47, 33 25, 15 37, 21 0.0068 0.103 0.947 0.024 1.01 0.818 1.21 -0.028 0.525 0.957 0.019 0.972 0.363 2.68 0.163 0.586 0.781 0.107 1.18 0.399 3.57 -0.349 0.555 0.529 0.277 0.705 0.246 2.01 PRS_PLINK_1.99526231496888e.08 FALSE 253.1 Pituitary hyperfunction Both 30 51 3 endocrine/metabolic brown 51, 30 5, 1 13, 10 12, 9 13, 6 0.0318 0.189 0.867 0.062 1.03 0.721 1.45 1.05 1.23 0.397 0.401 2.85 0.394 43.3 1.76 1.53 0.251 0.601 5.81 0.371 208 0.777 1.26 0.537 0.27 2.18 0.279 30.6 PRS_PLINK_1.99526231496888e.08 TRUE 253.11 Acromegaly and gigantism Both 3 11 3 endocrine/metabolic brown 11, 3 3, 0 2, 3 3, 0 3, 0 -0.291 1.63 0.859 0.066 0.748 0.0478 9.22 PRS_PLINK_1.99526231496888e.08 TRUE 253.2 Pituitary hypofunction Both 21 43 3 endocrine/metabolic brown 43, 21 5, 0 11, 11 10, 7 11, 3 0.142 0.234 0.545 0.263 1.15 0.797 2.04 1.42 1.54 0.357 0.448 4.15 0.383 540 1.82 1.62 0.262 0.582 6.17 0.32 4780 1.58 1.88 0.401 0.396 4.84 0.219 453 PRS_PLINK_1.99526231496888e.08 TRUE 253.3 Diabetes insipidus Both 7 17 3 endocrine/metabolic brown 17, 7 4, 1 4, 5 4, 0 4, 1 0.438 0.899 0.626 0.203 1.55 0.307 13.6 1.34 1.96 0.494 0.306 3.82 0.163 1080 0.116 2.03 0.954 0.02 1.12 0.0341 67 0.757 2.47 0.759 0.12 2.13 0.0595 705 PRS_PLINK_1.99526231496888e.08 TRUE 253.4 Anterior pituitary disorders Both 22 14 3 endocrine/metabolic brown 14, 22 4, 3 4, 6 2, 6 4, 7 0.0154 0.311 0.961 0.017 1.02 0.636 3.13 0.482 1.39 0.728 0.138 1.62 0.161 34.4 1.12 2.45 0.648 0.188 3.06 0.065 348 2.43 2.1 0.246 0.608 11.4 0.537 4320 PRS_PLINK_1.99526231496888e.08 TRUE 253.7 Other disorders of neurohypophysis Both 2 8 3 endocrine/metabolic brown 8, 2 -0.326 0.442 0.461 0.337 0.722 0.113 1.3 PRS_PLINK_1.99526231496888e.08 TRUE 255 Disorders of adrenal glands Both 98 260 3 endocrine/metabolic brown 260, 98 34, 11 92, 36 39, 19 64, 22 0.0447 0.0895 0.617 0.209 1.05 0.873 1.23 0.113 0.403 0.78 0.108 1.12 0.526 2.5 0.428 0.505 0.397 0.401 1.53 0.591 4.12 -0.114 0.442 0.796 0.099 0.892 0.383 2.14 PRS_PLINK_1.99526231496888e.08 FALSE 255.1 Adrenal hyperfunction Both 40 80 3 endocrine/metabolic brown 80, 40 9, 3 22, 10 18, 16 20, 8 0.108 0.154 0.482 0.317 1.11 0.833 1.48 -0.123 0.861 0.886 0.053 0.884 0.184 4.72 0.644 0.817 0.43 0.366 1.9 0.439 9.99 -0.233 0.863 0.787 0.104 0.792 0.164 4.02 PRS_PLINK_1.99526231496888e.08 TRUE 255.11 Cushing's syndrome Both 27 52 3 endocrine/metabolic brown 52, 27 8, 3 17, 10 9, 5 13, 6 -0.174 0.24 0.47 0.328 0.84 0.466 1.23 0.313 0.865 0.717 0.144 1.37 0.292 7.44 0.591 1.08 0.586 0.232 1.81 0.269 17.8 -0.292 0.977 0.765 0.116 0.747 0.118 4.34 PRS_PLINK_1.99526231496888e.08 TRUE 255.12 Hyperaldosteronism Both 3 25 3 endocrine/metabolic brown 25, 3 5, 0 6, 1 6, 1 6, 1 0.48 0.361 0.184 0.736 1.62 0.891 5.47 1.5 2.41 0.534 0.272 4.48 0.117 779 -0.245 3.26 0.94 0.027 0.783 0.000347 1060 -0.175 2.67 0.948 0.023 0.839 0.00116 314 PRS_PLINK_1.99526231496888e.08 TRUE 255.2 Adrenal hypofunction Both 57 126 3 endocrine/metabolic brown 126, 57 19, 6 41, 23 21, 10 32, 13 0.0265 0.128 0.836 0.078 1.03 0.792 1.28 0.456 0.557 0.412 0.385 1.58 0.572 4.8 0.477 0.742 0.521 0.283 1.61 0.415 7.59 0.302 0.653 0.643 0.191 1.35 0.398 4.96 PRS_PLINK_1.99526231496888e.08 FALSE 255.21 Glucocorticoid deficiency Both 55 103 3 endocrine/metabolic brown 103, 55 16, 8 31, 20 20, 9 26, 13 0.0122 0.13 0.925 0.034 1.01 0.773 1.26 0.175 0.567 0.758 0.121 1.19 0.419 3.56 -0.112 0.695 0.872 0.06 0.894 0.248 3.27 -0.158 0.646 0.807 0.093 0.854 0.246 2.93 PRS_PLINK_1.99526231496888e.08 FALSE 256 Ovarian dysfunction Female 269 410 3 endocrine/metabolic brown 410, 269 63, 30 142, 91 62, 38 101, 76 0.0519 0.0739 0.483 0.316 1.05 0.915 1.22 0.325 0.269 0.227 0.644 1.38 0.827 2.35 0.25 0.307 0.415 0.382 1.28 0.714 2.32 0.491 0.277 0.0768 1.115 1.63 0.963 2.81 PRS_PLINK_1.99526231496888e.08 FALSE 256.4 Polycystic ovaries Female 166 324 3 endocrine/metabolic brown 324, 166 42, 18 86, 40 76, 35 81, 50 0.134 0.0919 0.146 0.835 1.14 0.963 1.38 0.113 0.353 0.748 0.126 1.12 0.573 2.24 0.1 0.354 0.776 0.11 1.11 0.567 2.2 0.314 0.342 0.359 0.444 1.37 0.717 2.67 PRS_PLINK_1.99526231496888e.08 FALSE 257 Testicular dysfunction Male 137 36 3 endocrine/metabolic brown 36, 137 5, 22 9, 23 9, 41 9, 39 0.0806 0.21 0.701 0.154 1.08 0.763 1.8 -0.535 0.677 0.429 0.367 0.586 0.149 2.1 0.0808 0.609 0.895 0.048 1.08 0.315 3.45 0.0518 0.651 0.937 0.028 1.05 0.283 3.69 PRS_PLINK_1.99526231496888e.08 FALSE 257.1 Testicular hypofunction Male 135 36 3 endocrine/metabolic brown 36, 135 5, 18 10, 27 8, 35 9, 44 0.127 0.23 0.581 0.236 1.14 0.771 1.94 -0.202 0.637 0.751 0.124 0.817 0.229 2.7 0.266 0.633 0.674 0.171 1.31 0.375 4.33 0.311 0.674 0.644 0.191 1.37 0.349 5 PRS_PLINK_1.99526231496888e.08 FALSE 258 Iatrogenic endocrine disorders Both 4 14 3 endocrine/metabolic brown 14, 4 4, 0 4, 1 2, 2 4, 1 1.06 1.25 0.396 0.403 2.89 0.383 163 1.84 40.1 0.963 0.016 6.3 12.1 12.6 0.0366 105 1 0 1.04 0.829 1.43 0.106 37.4 0.998 0.001 1.11 1.25 1.2 PRS_PLINK_1.99526231496888e.08 TRUE 258.1 Postablative ovarian failure Female 15 47 3 endocrine/metabolic brown 47, 15 10, 4 15, 4 8, 4 12, 3 -0.196 0.418 0.638 0.195 0.822 0.357 1.79 -0.415 0.949 0.662 0.179 0.661 0.0801 4.14 -0.852 1.21 0.482 0.317 0.426 0.0189 3.43 -0.938 1.14 0.409 0.388 0.391 0.00822 3.12 PRS_PLINK_1.99526231496888e.08 TRUE 259 Other endocrine disorders Both 124 201 3 endocrine/metabolic brown 201, 124 31, 12 68, 46 32, 23 50, 25 -0.113 0.126 0.371 0.431 0.893 0.676 1.11 0.585 0.426 0.17 0.77 1.8 0.813 4.16 0.771 0.503 0.125 0.903 2.16 0.857 5.83 0.353 0.494 0.475 0.324 1.42 0.56 3.8 PRS_PLINK_1.99526231496888e.08 FALSE 260 Protein-calorie malnutrition Both 66 426 3 endocrine/metabolic brown 426, 66 60, 10 156, 23 55, 6 107, 18 0.144 0.138 0.298 0.526 1.16 0.876 1.5 -0.0771 0.401 0.848 0.072 0.926 0.43 2.11 -0.512 0.564 0.363 0.44 0.599 0.181 1.79 -0.0273 0.425 0.949 0.023 0.973 0.429 2.29 PRS_PLINK_1.99526231496888e.08 FALSE 260.1 Cachexia Both 6 35 3 endocrine/metabolic brown 35, 6 1, 0 9, 2 8, 3 9, 1 2.04 1.34 0.126 0.901 7.73 0.73 405 0.504 2.76 0.855 0.068 1.65 0.0372 333 1.65 3.1 0.594 0.226 5.21 0.0581 1420 5.72 30.1 0.849 0.071 305 3.3e-16 2.23e+21 PRS_PLINK_1.99526231496888e.08 TRUE 260.2 severe protein-calorie malnutrition Both 25 258 3 endocrine/metabolic brown 258, 25 37, 5 65, 10 62, 3 65, 4 -0.401 0.273 0.142 0.847 0.67 0.384 1.15 0.536 0.644 0.405 0.393 1.71 0.508 7.05 -0.643 0.724 0.374 0.427 0.526 0.111 2.3 -0.489 0.654 0.454 0.343 0.613 0.157 2.37 PRS_PLINK_1.99526231496888e.08 TRUE 260.22 Nutritional marasmus Both 9 98 3 endocrine/metabolic brown 98, 9 10, 0 25, 3 23, 4 25, 1 -0.111 0.427 0.795 0.1 0.895 0.368 2.2 1.37 1.59 0.389 0.411 3.93 0.0848 694 1.23 1.38 0.374 0.427 3.41 0.334 429 1.21 1.69 0.474 0.324 3.35 0.15 419000 PRS_PLINK_1.99526231496888e.08 TRUE 260.3 Adult failure to thrive Both 10 93 3 endocrine/metabolic brown 93, 10 12, 1 35, 5 11, 0 23, 2 -0.433 0.428 0.312 0.506 0.649 0.258 1.55 0.745 1.15 0.516 0.287 2.11 0.267 31.7 -1.1 1.5 0.462 0.335 0.332 2.89e-05 7.83 -0.512 1.14 0.652 0.186 0.599 0.0476 7.43 PRS_PLINK_1.99526231496888e.08 TRUE 260.6 Anorexia Both 35 141 3 endocrine/metabolic brown 141, 35 19, 2 56, 14 14, 6 35, 11 0.249 0.184 0.177 0.751 1.28 0.956 2.07 0.822 0.733 0.262 0.581 2.27 0.623 12 1.24 0.858 0.147 0.832 3.47 0.772 20.9 0.876 0.732 0.232 0.635 2.4 0.635 13.1 PRS_PLINK_1.99526231496888e.08 TRUE 260.7 Polyphagia Both 6 29 3 endocrine/metabolic brown 29, 6 4, 0 7, 1 7, 4 7, 1 0.445 0.709 0.53 0.275 1.56 0.425 9.49 2.71 18.4 0.883 0.054 15 1.54e-08 1.79e+09 3.58 2.37 0.131 0.884 35.8 1.09 106000 -0.0962 2.28 0.966 0.015 0.908 0.00831 232 PRS_PLINK_1.99526231496888e.08 TRUE 261 Vitamin deficiency Both 502 675 3 endocrine/metabolic brown 675, 502 95, 62 238, 169 98, 75 166, 149 0.154 0.065 0.0181 1.743 1.17 1.03 1.33 0.145 0.201 0.471 0.327 1.16 0.784 1.72 0.188 0.233 0.421 0.376 1.21 0.769 1.9 0.354 0.206 0.0863 1.064 1.42 0.957 2.13 PRS_PLINK_1.99526231496888e.08 FALSE 261.1 Vitamin A deficiency Both 5 20 3 endocrine/metabolic brown 20, 5 4, 2 6, 1 4, 2 5, 0 -0.761 0.918 0.407 0.39 0.467 0.376 3.76 0.0288 1.68 0.986 0.006 1.03 0.943 1.21 -0.0422 2.07 0.984 0.007 0.959 0.877 1.32 0.0125 1.95 0.995 0.002 1.01 0.0302 162 PRS_PLINK_1.99526231496888e.08 TRUE 261.2 Vitamin B-complex deficiencies Both 50 174 3 endocrine/metabolic brown 174, 50 29, 8 67, 16 17, 5 44, 14 0.0397 0.223 0.859 0.066 1.04 0.675 1.61 0.125 0.54 0.817 0.088 1.13 0.409 3.34 0.317 0.697 0.649 0.188 1.37 0.357 5.42 0.101 0.539 0.851 0.07 1.11 0.396 3.22 PRS_PLINK_1.99526231496888e.08 TRUE 261.4 Vitamin D deficiency Both 487 674 3 endocrine/metabolic brown 674, 487 95, 61 237, 161 98, 73 166, 145 0.15 0.065 0.0206 1.685 1.16 1.03 1.33 0.12 0.203 0.554 0.256 1.13 0.762 1.68 0.176 0.235 0.452 0.345 1.19 0.758 1.88 0.344 0.208 0.0976 1.011 1.41 0.945 2.12 PRS_PLINK_1.99526231496888e.08 FALSE 261.41 Rickets or osteomalacia Both 5 11 3 endocrine/metabolic brown 11, 5 3, 0 3, 1 2, 1 3, 3 1.77 1.83 0.334 0.476 5.85 0.42 386 0.341 125 0.998 0.001 1.41 0.498 0.596 -0.0616 800 1 0 0.94 0.621 1.43 -1.25 225 0.996 0.002 0.288 0.44 8.44 PRS_PLINK_1.99526231496888e.08 TRUE 262 Mineral deficiency NEC Both 87 295 3 endocrine/metabolic brown 295, 87 37, 13 107, 32 41, 7 73, 26 0.119 0.101 0.238 0.623 1.13 0.927 1.37 0.000579 0.4 0.999 0.001 1 0.472 2.21 -0.82 0.552 0.138 0.861 0.441 0.144 1.25 0.0809 0.429 0.851 0.07 1.08 0.48 2.52 PRS_PLINK_1.99526231496888e.08 FALSE 263 Other nutritional deficiency Both 92 333 3 endocrine/metabolic brown 333, 92 45, 9 111, 25 56, 19 82, 28 0.152 0.134 0.254 0.595 1.16 0.905 1.52 -0.0126 0.425 0.976 0.01 0.988 0.441 2.36 0.578 0.475 0.224 0.65 1.78 0.727 4.59 0.443 0.43 0.303 0.519 1.56 0.691 3.75 PRS_PLINK_1.99526231496888e.08 FALSE 264 Lack of normal physiological development Both 9 40 3 endocrine/metabolic brown 40, 9 4, 0 10, 1 10, 4 10, 4 0.175 0.353 0.62 0.208 1.19 0.694 6.48 -1.05 3.09 0.733 0.135 0.349 3.01e-05 690 2.06 2.21 0.351 0.455 7.86 0.263 2380 1.44 2.17 0.507 0.295 4.22 0.129 9910 PRS_PLINK_1.99526231496888e.08 TRUE 264.2 Failure to thrive (childhood) Both 3 31 3 endocrine/metabolic brown 31, 3 5, 0 8, 2 7, 0 8, 1 0.183 0.405 0.652 0.186 1.2 0.302 3.25 0.458 1.91 0.811 0.091 1.58 0.031 4810 0.245 2.27 0.914 0.039 1.28 0.0162 760 PRS_PLINK_1.99526231496888e.08 TRUE 264.9 Lack of normal physiological development, unspecified Both 6 14 3 endocrine/metabolic brown 14, 6 1, 1 4, 2 2, 0 4, 3 2.29 1.74 0.187 0.729 9.88 0.602 41100 5.24 16 0.743 0.129 189 8.62e-06 258 -0.933 26300000 1 0 0.393 4.67e-05 25400 4 9.89 0.685 0.164 54.9 11.9 3770 PRS_PLINK_1.99526231496888e.08 TRUE 269 Proteinuria Both 81 344 3 endocrine/metabolic brown 344, 81 53, 11 123, 29 50, 14 84, 19 0.0622 0.104 0.551 0.259 1.06 0.861 1.29 0.146 0.399 0.715 0.146 1.16 0.543 2.59 0.408 0.462 0.378 0.423 1.5 0.621 3.76 -0.000927 0.434 0.998 0.001 0.999 0.432 2.36 PRS_PLINK_1.99526231496888e.08 FALSE 270 Disorders of protein plasma/amino-acid transport and metabolism Both 35 213 3 endocrine/metabolic brown 213, 35 22, 4 56, 10 50, 4 53, 12 0.00914 0.186 0.961 0.017 1.01 0.649 1.39 -0.181 0.657 0.783 0.106 0.835 0.239 3.28 -1.42 0.804 0.0782 1.107 0.243 0.04 1.18 -0.106 0.653 0.872 0.06 0.9 0.257 3.47 PRS_PLINK_1.99526231496888e.08 TRUE 270.1 Disturbances of amino-acid transport Both 8 61 3 endocrine/metabolic brown 61, 8 9, 1 19, 1 12, 1 14, 2 -0.258 0.454 0.57 0.244 0.772 0.314 1.92 -1.12 1.83 0.54 0.268 0.325 0.00014 20.5 0.383 1.31 0.769 0.114 1.47 0.124 19.6 1.56 1.66 0.346 0.46 4.75 0.0923 85100 PRS_PLINK_1.99526231496888e.08 TRUE 270.11 Disturbances of sulphur-bearing amino-acid metabolism Both 7 55 3 endocrine/metabolic brown 55, 7 8, 1 18, 1 9, 0 14, 3 -0.247 0.495 0.617 0.21 0.781 0.289 2.03 -0.638 80.4 0.994 0.003 0.528 0.039 4.05 -0.687 1.77 0.698 0.156 0.503 0.000125 8.53 0.689 404 0.999 0.001 1.99 1.27 2.67 PRS_PLINK_1.99526231496888e.08 TRUE 270.2 Disorders of amino-acid metabolism Both 6 33 3 endocrine/metabolic brown 33, 6 6, 2 13, 1 3, 1 8, 2 -0.0801 0.628 0.898 0.046 0.923 0.261 2.82 -1.62 1.72 0.345 0.462 0.197 2.73e-05 3.6 2.43 2.3 0.29 0.538 11.4 0.453 1460 -0.999 1.48 0.5 0.301 0.368 0.000228 4.78 PRS_PLINK_1.99526231496888e.08 TRUE 270.3 Disorders of plasma protein metabolism Both 24 138 3 endocrine/metabolic brown 138, 24 16, 3 35, 8 33, 3 35, 7 -0.0322 0.215 0.881 0.055 0.968 0.548 1.38 -0.0547 0.74 0.941 0.026 0.947 0.241 4.3 -1.28 1.01 0.208 0.683 0.279 0.0231 1.98 -0.267 0.755 0.724 0.14 0.766 0.18 3.55 PRS_PLINK_1.99526231496888e.08 TRUE 270.32 Paraproteinemia Both 13 58 3 endocrine/metabolic brown 58, 13 7, 1 15, 5 13, 1 15, 3 -0.356 0.442 0.42 0.377 0.7 0.277 1.66 0.596 1.34 0.656 0.183 1.81 0.127 47 0.894 1.75 0.609 0.215 2.45 0.123 225 0.32 1.38 0.816 0.088 1.38 0.0464 166 PRS_PLINK_1.99526231496888e.08 TRUE 270.33 Amyloidosis Both 0 15 3 endocrine/metabolic brown 15, 0 1 4 3 4 PRS_PLINK_1.99526231496888e.08 TRUE 270.34 Alpha-1-antitrypsin deficiency Both 5 13 3 endocrine/metabolic brown 13, 5 2, 0 4, 2 2, 3 3, 0 0.751 0.947 0.428 0.369 2.12 0.449 200 -0.217 29600000 1 0 0.805 1.62e-06 86 -0.185 7170 1 0 0.831 0.657 1.93 PRS_PLINK_1.99526231496888e.08 TRUE 270.38 Other specified disorders of plasma protein metabolism Both 9 61 3 endocrine/metabolic brown 61, 9 12, 2 17, 2 13, 2 15, 3 -0.0264 0.241 0.913 0.04 0.974 0.448 1.44 -0.451 1.36 0.74 0.131 0.637 0.0281 53.5 -0.666 1.17 0.569 0.245 0.514 0.0424 4.61 -0.385 1.12 0.732 0.136 0.681 0.0696 5.65 PRS_PLINK_1.99526231496888e.08 TRUE 271 Disorders of carbohydrate transport and metabolism Both 167 630 3 endocrine/metabolic brown 630, 167 93, 24 197, 62 116, 26 157, 36 -0.0286 0.0911 0.754 0.123 0.972 0.8 1.15 0.172 0.278 0.536 0.271 1.19 0.698 2.07 -0.124 0.318 0.696 0.158 0.883 0.474 1.65 -0.153 0.302 0.611 0.214 0.858 0.477 1.56 PRS_PLINK_1.99526231496888e.08 FALSE 271.3 Intestinal disaccharidase deficiencies and disaccharide malabsorption Both 159 605 3 endocrine/metabolic brown 605, 159 89, 23 190, 58 111, 24 150, 35 -0.00391 0.1 0.969 0.014 0.996 0.808 1.2 0.143 0.286 0.617 0.21 1.15 0.668 2.04 -0.176 0.328 0.592 0.228 0.839 0.44 1.6 -0.112 0.309 0.718 0.144 0.894 0.491 1.65 PRS_PLINK_1.99526231496888e.08 FALSE 271.9 Other disorders of carbohydrate transport and metabolism Both 13 32 3 endocrine/metabolic brown 32, 13 4, 3 9, 5 7, 2 8, 2 -0.23 0.24 0.339 0.469 0.795 0.166 1.09 -2.2 1.98 0.269 0.571 0.111 9.66e-05 3.32 -0.212 1.84 0.908 0.042 0.809 0.717 0.935 -3.46 2.74 0.208 0.682 0.0316 8.94e-07 3.61 PRS_PLINK_1.99526231496888e.08 TRUE 272 Disorders of lipoid metabolism Both 513 741 3 endocrine/metabolic brown 741, 513 108, 63 237, 187 132, 76 185, 132 -0.0578 0.0674 0.391 0.408 0.944 0.825 1.07 0.314 0.224 0.162 0.791 1.37 0.886 2.13 0.00901 0.256 0.972 0.012 1.01 0.613 1.66 0.204 0.23 0.375 0.426 1.23 0.785 1.93 PRS_PLINK_1.99526231496888e.08 FALSE 272.1 Hyperlipidemia Both 510 741 3 endocrine/metabolic brown 741, 510 108, 63 237, 186 132, 76 185, 130 -0.0628 0.0678 0.354 0.451 0.939 0.82 1.07 0.307 0.224 0.17 0.769 1.36 0.881 2.12 0.00901 0.256 0.972 0.012 1.01 0.613 1.66 0.181 0.231 0.433 0.363 1.2 0.765 1.89 PRS_PLINK_1.99526231496888e.08 FALSE 272.11 Hypercholesterolemia Both 176 461 3 endocrine/metabolic brown 461, 176 69, 22 143, 64 87, 23 115, 48 -0.0263 0.106 0.803 0.095 0.974 0.776 1.18 0.33 0.351 0.347 0.46 1.39 0.711 2.8 -0.0156 0.416 0.97 0.013 0.984 0.437 2.24 0.205 0.353 0.561 0.251 1.23 0.621 2.48 PRS_PLINK_1.99526231496888e.08 FALSE 272.12 Hyperglyceridemia Both 64 201 3 endocrine/metabolic brown 201, 64 28, 8 62, 20 39, 8 48, 19 0.0209 0.141 0.882 0.055 1.02 0.747 1.31 0.102 0.522 0.846 0.073 1.11 0.415 3.12 -0.0123 0.626 0.984 0.007 0.988 0.294 3.49 0.39 0.566 0.49 0.309 1.48 0.507 4.58 PRS_PLINK_1.99526231496888e.08 FALSE 272.13 Mixed hyperlipidemia Both 147 328 3 endocrine/metabolic brown 328, 147 49, 14 105, 51 59, 16 82, 51 0.0609 0.108 0.572 0.242 1.06 0.854 1.3 0.772 0.402 0.0548 1.261 2.16 1.02 4.89 0.261 0.493 0.597 0.224 1.3 0.502 3.48 0.915 0.406 0.0242 1.616 2.5 1.16 5.67 PRS_PLINK_1.99526231496888e.08 FALSE 272.9 Unspecified disorder of lipoid metabolism Both 14 44 3 endocrine/metabolic brown 44, 14 7, 2 12, 4 10, 3 11, 3 0.0385 0.558 0.945 0.025 1.04 0.338 3.22 -1.44 1.46 0.322 0.492 0.236 0.000461 2.89 -1.17 1.46 0.422 0.374 0.309 0.00185 4.31 -0.024 1.36 0.986 0.006 0.976 0.0897 1150 PRS_PLINK_1.99526231496888e.08 TRUE 274 Gout and other crystal arthropathies Both 60 338 3 endocrine/metabolic brown 338, 60 48, 11 113, 20 54, 5 85, 20 0.254 0.149 0.0881 1.055 1.29 0.969 1.73 -0.462 0.432 0.285 0.545 0.63 0.273 1.49 -0.977 0.575 0.0893 1.049 0.376 0.111 1.13 -0.00414 0.423 0.992 0.003 0.996 0.442 2.32 PRS_PLINK_1.99526231496888e.08 FALSE 274.1 Gout Both 58 319 3 endocrine/metabolic brown 319, 58 47, 11 105, 20 53, 5 80, 18 0.218 0.151 0.149 0.826 1.24 0.922 1.66 -0.443 0.434 0.307 0.512 0.642 0.277 1.52 -0.816 0.555 0.142 0.848 0.442 0.136 1.28 -0.0769 0.435 0.86 0.066 0.926 0.4 2.2 PRS_PLINK_1.99526231496888e.08 FALSE 274.11 Gouty arthropathy Both 42 156 3 endocrine/metabolic brown 156, 42 24, 8 51, 14 26, 4 39, 13 -0.00376 0.231 0.987 0.006 0.996 0.638 1.57 -0.237 0.575 0.68 0.168 0.789 0.261 2.47 -0.675 0.687 0.326 0.487 0.509 0.125 1.84 0.181 0.541 0.738 0.132 1.2 0.44 3.45 PRS_PLINK_1.99526231496888e.08 TRUE 274.2 Crystal arthropathies Both 3 24 3 endocrine/metabolic brown 24, 3 3, 0 6, 1 6, 1 6, 1 0.478 0.822 0.561 0.251 1.61 0.305 44.8 2.2 73.3 0.976 0.01 8.98 1.03e-10 7.86e+11 -1.26 11.2 0.911 0.041 0.283 0.255 0.318 1.1 3.05 0.719 0.143 2.99 0.754 3.61 PRS_PLINK_1.99526231496888e.08 TRUE 274.21 Chondrocalcinosis Both 3 18 3 endocrine/metabolic brown 18, 3 3, 0 4, 1 4, 1 5, 1 0.565 0.857 0.51 0.292 1.76 0.331 97 -0.845 406 0.998 0.001 0.43 0.00309 0.168 0.971 382 0.998 0.001 2.64 1.14 8.06 1.1 3.05 0.719 0.143 2.99 0.0316 3.61 PRS_PLINK_1.99526231496888e.08 TRUE 275 Disorders of mineral metabolism Both 151 904 3 endocrine/metabolic brown 904, 151 129, 20 313, 56 141, 26 222, 42 0.167 0.0848 0.0483 1.316 1.18 1 1.39 0.0949 0.282 0.737 0.133 1.1 0.641 1.95 0.146 0.323 0.65 0.187 1.16 0.614 2.2 0.196 0.292 0.502 0.299 1.22 0.691 2.2 PRS_PLINK_1.99526231496888e.08 FALSE 275.1 Disorders of iron metabolism Both 12 48 4 hematopoietic darkorange1 48, 12 6, 0 12, 4 12, 3 12, 3 -0.0793 0.258 0.759 0.12 0.924 0.602 1.7 1.26 2.59 0.627 0.203 3.52 0.0592 4.15e+09 0.24 1.67 0.886 0.053 1.27 0.000143 583000 0.123 1.95 0.95 0.022 1.13 0.0299 188 PRS_PLINK_1.99526231496888e.08 TRUE 275.11 Hereditary hemochromatosis Both 6 19 4 hematopoietic darkorange1 19, 6 3, 0 5, 3 4, 1 5, 2 -0.226 0.451 0.616 0.21 0.798 0.203 1.74 6.8 13.6 0.616 0.211 900 1.92e-07 4.02e+11 -0.125 734 1 0 0.882 0.415 15.2 -0.111 822 1 0 0.895 0.464 1.41 PRS_PLINK_1.99526231496888e.08 TRUE 275.2 Disorders of copper metabolism Both 2 14 3 endocrine/metabolic brown 14, 2 4, 0 3, 2 3, 0 4, 0 -0.707 1.58 0.655 0.184 0.493 2.69e-06 6.83 0.167 190 0.999 0 1.18 1.32 12.3 PRS_PLINK_1.99526231496888e.08 TRUE 275.3 Disorders of magnesium metabolism Both 34 258 3 endocrine/metabolic brown 258, 34 36, 5 72, 11 55, 9 65, 8 0.127 0.132 0.334 0.476 1.14 0.859 1.43 0.447 0.614 0.467 0.331 1.56 0.492 5.85 0.289 0.595 0.627 0.202 1.33 0.422 4.6 0.099 0.62 0.873 0.059 1.1 0.327 4.12 PRS_PLINK_1.99526231496888e.08 TRUE 275.5 Disorders of calcium/phosphorus metabolism Both 115 759 3 endocrine/metabolic brown 759, 115 103, 16 264, 40 117, 22 187, 33 0.112 0.108 0.298 0.526 1.12 0.895 1.37 -0.0558 0.322 0.862 0.064 0.946 0.51 1.82 0.173 0.352 0.623 0.206 1.19 0.597 2.41 0.107 0.328 0.745 0.128 1.11 0.589 2.17 PRS_PLINK_1.99526231496888e.08 FALSE 275.51 Hypocalcemia Both 32 263 3 endocrine/metabolic brown 263, 32 35, 4 89, 12 42, 3 66, 13 0.432 0.249 0.083 1.081 1.54 0.947 2.59 0.11 0.624 0.861 0.065 1.12 0.34 4.46 -0.418 0.703 0.553 0.258 0.659 0.143 2.79 0.564 0.593 0.342 0.467 1.76 0.577 6.36 PRS_PLINK_1.99526231496888e.08 TRUE 275.53 Disorders of phosphorus metabolism Both 39 288 3 endocrine/metabolic brown 288, 39 36, 5 80, 11 62, 12 72, 9 0.066 0.166 0.69 0.161 1.07 0.71 1.41 -0.121 0.552 0.826 0.083 0.886 0.305 2.84 0.216 0.553 0.696 0.157 1.24 0.432 3.95 -0.127 0.596 0.831 0.08 0.88 0.273 3.04 PRS_PLINK_1.99526231496888e.08 TRUE 275.6 Hypercalcemia Both 59 325 3 endocrine/metabolic brown 325, 59 52, 13 110, 18 54, 8 78, 18 0.0697 0.15 0.643 0.192 1.07 0.766 1.39 -0.411 0.408 0.314 0.504 0.663 0.3 1.49 -0.555 0.495 0.262 0.581 0.574 0.209 1.5 -0.0669 0.406 0.869 0.061 0.935 0.426 2.09 PRS_PLINK_1.99526231496888e.08 FALSE 276 Disorders of fluid, electrolyte, and acid-base balance Both 319 933 3 endocrine/metabolic brown 933, 319 130, 47 305, 120 162, 52 232, 71 -0.0277 0.0672 0.68 0.167 0.973 0.847 1.1 0.0432 0.207 0.835 0.078 1.04 0.7 1.57 -0.0973 0.238 0.683 0.165 0.907 0.57 1.45 -0.206 0.221 0.353 0.452 0.814 0.53 1.26 PRS_PLINK_1.99526231496888e.08 FALSE 276.1 Electrolyte imbalance Both 208 828 3 endocrine/metabolic brown 828, 208 110, 30 276, 76 138, 33 207, 51 -0.0575 0.0877 0.512 0.29 0.944 0.788 1.11 -0.00344 0.249 0.989 0.005 0.997 0.619 1.63 -0.133 0.289 0.646 0.19 0.876 0.498 1.54 -0.132 0.261 0.612 0.213 0.876 0.529 1.47 PRS_PLINK_1.99526231496888e.08 FALSE 276.11 Hyperosmolality and/or hypernatremia Both 11 93 3 endocrine/metabolic brown 93, 11 18, 4 30, 4 15, 0 23, 2 -0.795 0.431 0.0651 1.186 0.452 0.184 1.05 -0.373 0.734 0.611 0.214 0.688 0.166 2.88 -0.91 1.37 0.507 0.295 0.402 0.00419 8.3 -0.679 0.965 0.482 0.317 0.507 0.0593 3.7 PRS_PLINK_1.99526231496888e.08 TRUE 276.12 Hyposmolality and/or hyponatremia Both 70 383 3 endocrine/metabolic brown 383, 70 55, 11 125, 24 68, 15 93, 12 -0.13 0.15 0.384 0.416 0.878 0.641 1.16 -0.0817 0.399 0.838 0.077 0.922 0.43 2.06 0.199 0.447 0.656 0.183 1.22 0.515 2.99 -0.484 0.451 0.283 0.548 0.616 0.251 1.51 PRS_PLINK_1.99526231496888e.08 FALSE 276.13 Hyperpotassemia Both 93 461 3 endocrine/metabolic brown 461, 93 69, 15 144, 31 84, 18 115, 21 -0.0714 0.125 0.568 0.245 0.931 0.71 1.17 0.00913 0.349 0.979 0.009 1.01 0.516 2.04 -0.0312 0.394 0.937 0.028 0.969 0.446 2.12 -0.118 0.369 0.75 0.125 0.889 0.434 1.86 PRS_PLINK_1.99526231496888e.08 FALSE 276.14 Hypopotassemia Both 99 494 3 endocrine/metabolic brown 494, 99 68, 18 173, 26 73, 16 124, 28 -0.0166 0.121 0.891 0.05 0.984 0.757 1.23 -0.493 0.343 0.15 0.823 0.611 0.314 1.21 -0.274 0.385 0.477 0.322 0.76 0.355 1.61 -0.184 0.35 0.599 0.223 0.832 0.424 1.66 PRS_PLINK_1.99526231496888e.08 FALSE 276.4 Acid-base balance disorder Both 62 406 3 endocrine/metabolic brown 406, 62 57, 7 143, 26 58, 12 102, 13 -0.023 0.148 0.876 0.057 0.977 0.701 1.27 0.297 0.438 0.497 0.304 1.35 0.589 3.42 0.499 0.483 0.301 0.521 1.65 0.644 4.48 0.0533 0.474 0.911 0.041 1.05 0.419 2.84 PRS_PLINK_1.99526231496888e.08 FALSE 276.41 Acidosis Both 53 358 3 endocrine/metabolic brown 358, 53 50, 4 125, 25 55, 11 88, 9 -0.0758 0.165 0.646 0.19 0.927 0.641 1.24 0.761 0.525 0.147 0.833 2.14 0.814 6.98 0.856 0.562 0.128 0.894 2.35 0.803 8.09 0.178 0.58 0.759 0.12 1.19 0.385 4.24 PRS_PLINK_1.99526231496888e.08 FALSE 276.42 Alkalosis Both 15 91 3 endocrine/metabolic brown 91, 15 18, 4 23, 3 22, 3 23, 4 -0.0125 0.378 0.974 0.012 0.988 0.474 2.12 -0.119 0.93 0.898 0.047 0.888 0.119 5.75 -0.357 0.961 0.71 0.149 0.7 0.0959 4.24 -0.625 0.978 0.523 0.281 0.535 0.0519 3.31 PRS_PLINK_1.99526231496888e.08 TRUE 276.5 Hypovolemia Both 190 841 3 endocrine/metabolic brown 841, 190 115, 29 279, 76 140, 28 210, 38 -0.046 0.0838 0.583 0.235 0.955 0.802 1.12 0.0991 0.25 0.692 0.16 1.1 0.683 1.82 -0.198 0.293 0.499 0.302 0.82 0.461 1.46 -0.298 0.272 0.273 0.563 0.742 0.437 1.27 PRS_PLINK_1.99526231496888e.08 FALSE 276.6 Fluid overload Both 40 216 3 endocrine/metabolic brown 216, 40 24, 4 70, 17 38, 5 53, 11 0.213 0.217 0.326 0.487 1.24 0.812 1.92 0.577 0.651 0.376 0.425 1.78 0.542 7.21 -0.156 0.758 0.837 0.077 0.856 0.182 3.94 0.144 0.645 0.824 0.084 1.15 0.347 4.39 PRS_PLINK_1.99526231496888e.08 TRUE 276.8 Polydipsia Both 15 36 3 endocrine/metabolic brown 36, 15 5, 0 9, 1 9, 3 9, 10 0.673 0.341 0.0482 1.317 1.96 1.19 8.39 0.243 194 0.999 0 1.28 0.819 1.8 1.17 1.63 0.471 0.327 3.24 0.182 477 1.31 1.65 0.428 0.369 3.71 0.262 472 PRS_PLINK_1.99526231496888e.08 TRUE 277 Other disorders of metabolism Both 234 892 3 endocrine/metabolic brown 892, 234 130, 29 289, 77 153, 40 223, 62 -0.0123 0.0736 0.867 0.062 0.988 0.848 1.13 0.18 0.248 0.468 0.33 1.2 0.745 1.96 0.199 0.28 0.477 0.321 1.22 0.708 2.12 0.18 0.255 0.479 0.319 1.2 0.732 1.99 PRS_PLINK_1.99526231496888e.08 FALSE 277.2 Other disorders of purine and pyrimidine metabolism Both 15 81 3 endocrine/metabolic brown 81, 15 14, 2 20, 5 20, 1 20, 3 -0.696 0.374 0.0627 1.203 0.498 0.231 1.07 0.567 0.94 0.546 0.263 1.76 0.322 15.1 -2.59 1.91 0.175 0.756 0.0748 2.54e-08 2.68 0.241 1.01 0.812 0.09 1.27 0.186 10.5 PRS_PLINK_1.99526231496888e.08 TRUE 277.4 Disorders of bilirubin excretion Both 26 126 3 endocrine/metabolic brown 126, 26 18, 2 37, 10 26, 3 31, 6 -0.119 0.241 0.622 0.206 0.888 0.498 1.33 0.201 0.835 0.81 0.092 1.22 0.256 7.4 0.389 0.974 0.689 0.162 1.48 0.208 12.4 0.495 0.826 0.549 0.261 1.64 0.352 10.1 PRS_PLINK_1.99526231496888e.08 TRUE 277.5 Other disorders of lipoid metabolism Both 51 239 3 endocrine/metabolic brown 239, 51 37, 8 72, 17 47, 9 60, 13 0.127 0.119 0.285 0.544 1.14 0.878 1.4 -0.0964 0.485 0.843 0.074 0.908 0.361 2.39 -0.107 0.536 0.842 0.075 0.899 0.314 2.6 -0.107 0.51 0.834 0.079 0.899 0.332 2.55 PRS_PLINK_1.99526231496888e.08 FALSE 277.51 Lipoprotein disorders Both 42 194 3 endocrine/metabolic brown 194, 42 30, 6 59, 13 38, 8 48, 12 0.147 0.12 0.219 0.66 1.16 0.904 1.44 -0.0135 0.557 0.981 0.008 0.987 0.345 3.04 0.0572 0.607 0.925 0.034 1.06 0.325 3.54 0.0737 0.564 0.896 0.048 1.08 0.364 3.43 PRS_PLINK_1.99526231496888e.08 TRUE 277.7 Dysmetabolic syndrome X Both 95 263 3 endocrine/metabolic brown 263, 95 45, 8 83, 39 47, 14 65, 29 0.132 0.11 0.23 0.638 1.14 0.915 1.4 0.932 0.452 0.039 1.409 2.54 1.1 6.49 0.514 0.521 0.324 0.489 1.67 0.617 4.82 0.828 0.462 0.0734 1.134 2.29 0.965 5.89 PRS_PLINK_1.99526231496888e.08 FALSE 278 Overweight, obesity and other hyperalimentation Both 716 553 3 endocrine/metabolic brown 553, 716 80, 98 191, 237 84, 85 138, 222 -0.00436 0.0576 0.94 0.027 0.996 0.891 1.11 -0.00891 0.186 0.962 0.017 0.991 0.689 1.42 -0.183 0.223 0.41 0.387 0.832 0.541 1.28 0.223 0.19 0.241 0.618 1.25 0.863 1.81 PRS_PLINK_1.99526231496888e.08 FALSE 278.1 Obesity Both 603 553 3 endocrine/metabolic brown 553, 603 80, 83 191, 202 84, 69 138, 190 0.00784 0.0593 0.895 0.048 1.01 0.899 1.13 0.0126 0.196 0.949 0.023 1.01 0.692 1.48 -0.194 0.235 0.408 0.389 0.824 0.523 1.29 0.262 0.199 0.187 0.728 1.3 0.884 1.91 PRS_PLINK_1.99526231496888e.08 FALSE 278.11 Morbid obesity Both 361 548 3 endocrine/metabolic brown 548, 361 77, 44 193, 133 82, 41 136, 105 -0.0413 0.0687 0.548 0.261 0.96 0.836 1.09 0.158 0.229 0.49 0.31 1.17 0.754 1.83 -0.216 0.283 0.444 0.353 0.805 0.465 1.39 0.257 0.233 0.271 0.567 1.29 0.825 2.04 PRS_PLINK_1.99526231496888e.08 FALSE 278.3 Localized adiposity Both 16 102 3 endocrine/metabolic brown 102, 16 13, 1 27, 7 23, 3 26, 3 -0.0441 0.176 0.803 0.095 0.957 0.45 1.25 0.834 1.27 0.51 0.292 2.3 0.171 291 1.35 1.45 0.353 0.452 3.86 0.276 928 0.332 1.2 0.782 0.107 1.39 0.168 22.9 PRS_PLINK_1.99526231496888e.08 TRUE 278.4 Abnormal weight gain Both 201 480 3 endocrine/metabolic brown 480, 201 72, 29 168, 71 70, 19 119, 65 0.0439 0.0793 0.58 0.237 1.04 0.89 1.21 0.0718 0.272 0.792 0.101 1.07 0.639 1.84 -0.275 0.343 0.423 0.374 0.76 0.388 1.47 0.25 0.28 0.372 0.429 1.28 0.751 2.22 PRS_PLINK_1.99526231496888e.08 FALSE 279 Disorders involving the immune mechanism Both 130 707 3 endocrine/metabolic brown 707, 130 114, 22 234, 45 114, 14 176, 37 -0.00494 0.11 0.964 0.016 0.995 0.794 1.22 -0.118 0.289 0.683 0.165 0.889 0.508 1.59 -0.62 0.373 0.0967 1.014 0.538 0.251 1.11 0.093 0.297 0.754 0.122 1.1 0.616 1.99 PRS_PLINK_1.99526231496888e.08 FALSE 279.1 Immunity deficiency Both 57 269 3 endocrine/metabolic brown 269, 57 34, 5 69, 18 65, 11 67, 17 0.0764 0.163 0.64 0.194 1.08 0.771 1.46 0.561 0.536 0.295 0.53 1.75 0.652 5.48 0.0225 0.571 0.969 0.014 1.02 0.339 3.39 0.795 0.574 0.166 0.779 2.21 0.764 7.66 PRS_PLINK_1.99526231496888e.08 FALSE 279.11 Deficiency of humoral immunity Both 18 83 3 endocrine/metabolic brown 83, 18 14, 3 28, 7 13, 2 21, 5 -0.183 0.347 0.599 0.223 0.833 0.423 1.64 -0.24 0.843 0.776 0.11 0.787 0.151 4.3 -0.735 1.12 0.511 0.291 0.479 0.0553 3.53 0.235 0.887 0.791 0.102 1.27 0.236 7.48 PRS_PLINK_1.99526231496888e.08 TRUE 279.2 Autoimmune disease NEC Both 53 254 3 endocrine/metabolic brown 254, 53 37, 10 86, 19 40, 7 63, 11 -0.134 0.181 0.457 0.34 0.874 0.595 1.22 -0.317 0.472 0.502 0.3 0.728 0.29 1.87 -0.775 0.63 0.219 0.66 0.461 0.122 1.58 -0.471 0.547 0.389 0.41 0.624 0.215 1.85 PRS_PLINK_1.99526231496888e.08 FALSE 279.7 Other immunological findings Both 297 853 3 endocrine/metabolic brown 853, 297 124, 36 276, 106 149, 47 210, 78 0.0785 0.0652 0.229 0.64 1.08 0.949 1.22 0.206 0.228 0.365 0.438 1.23 0.794 1.93 0.00645 0.258 0.98 0.009 1.01 0.61 1.67 0.245 0.236 0.3 0.523 1.28 0.812 2.04 PRS_PLINK_1.99526231496888e.08 FALSE 279.8 Other specified disorders involving the immune mechanism Both 43 205 3 endocrine/metabolic brown 205, 43 32, 7 71, 13 31, 6 51, 11 -0.0518 0.181 0.775 0.111 0.949 0.643 1.32 -0.554 0.538 0.303 0.518 0.575 0.198 1.7 -0.304 0.646 0.638 0.195 0.738 0.199 2.61 -0.232 0.562 0.679 0.168 0.793 0.266 2.45 PRS_PLINK_1.99526231496888e.08 TRUE 280 Iron deficiency anemias Both 250 694 4 hematopoietic darkorange1 694, 250 107, 50 219, 79 124, 27 172, 68 0.0419 0.0748 0.575 0.241 1.04 0.897 1.2 -0.261 0.225 0.245 0.611 0.77 0.498 1.2 -0.73 0.278 0.00858 2.067 0.482 0.278 0.822 -0.162 0.228 0.477 0.322 0.85 0.546 1.33 PRS_PLINK_1.99526231496888e.08 FALSE 280.1 Iron deficiency anemias, unspecified or not due to blood loss Both 245 693 4 hematopoietic darkorange1 693, 245 107, 49 218, 77 124, 27 172, 66 0.0386 0.0752 0.608 0.216 1.04 0.893 1.2 -0.266 0.227 0.242 0.617 0.767 0.494 1.2 -0.712 0.278 0.0105 1.977 0.491 0.282 0.839 -0.162 0.23 0.48 0.319 0.85 0.544 1.33 PRS_PLINK_1.99526231496888e.08 FALSE 280.2 Iron deficiency anemia secondary to blood loss (chronic) Both 88 386 4 hematopoietic darkorange1 386, 88 54, 18 117, 33 74, 4 97, 24 -0.0383 0.122 0.753 0.123 0.962 0.738 1.2 -0.204 0.353 0.563 0.25 0.815 0.414 1.64 -1.73 0.553 0.00177 2.751 0.177 0.0512 0.5 -0.412 0.367 0.261 0.583 0.662 0.325 1.35 PRS_PLINK_1.99526231496888e.08 FALSE 281 Other deficiency anemia Both 25 115 4 hematopoietic darkorange1 115, 25 15, 4 41, 4 16, 3 29, 9 0.317 0.212 0.134 0.872 1.37 0.943 2.12 -1.17 0.805 0.146 0.836 0.31 0.053 1.52 -0.977 0.974 0.316 0.501 0.376 0.0381 2.3 0.15 0.709 0.833 0.08 1.16 0.312 4.74 PRS_PLINK_1.99526231496888e.08 TRUE 281.1 Megaloblastic anemia Both 19 69 4 hematopoietic darkorange1 69, 19 8, 3 18, 3 16, 4 17, 6 0.248 0.187 0.185 0.732 1.28 0.909 2.14 -1.03 1.19 0.388 0.411 0.358 0.016 3.13 -0.667 1.02 0.514 0.289 0.513 0.0584 3.21 -1.38 1.28 0.282 0.55 0.251 0.0114 2.39 PRS_PLINK_1.99526231496888e.08 TRUE 281.11 Pernicious anemia Both 13 33 4 hematopoietic darkorange1 33, 13 6, 4 10, 0 6, 2 8, 6 0.502 0.539 0.352 0.453 1.65 0.635 4.73 -1.56 1.64 0.339 0.47 0.209 0.00209 3.87 -0.271 1.31 0.837 0.077 0.763 0.0106 15.2 0.55 1.13 0.625 0.204 1.73 0.256 16.1 PRS_PLINK_1.99526231496888e.08 TRUE 281.12 Other vitamin B12 deficiency anemia Both 13 53 4 hematopoietic darkorange1 53, 13 5, 2 16, 2 10, 2 13, 4 0.214 0.257 0.406 0.391 1.24 0.799 2.05 -1.94 1.6 0.225 0.648 0.143 5.66e-05 2.92 -2 1.8 0.268 0.573 0.136 0.000347 1.85 -0.824 1.45 0.571 0.244 0.439 0.0244 5.6 PRS_PLINK_1.99526231496888e.08 TRUE 281.9 Deficiency anemias Both 8 51 4 hematopoietic darkorange1 51, 8 6, 0 18, 2 7, 1 13, 3 0.15 0.547 0.784 0.106 1.16 0.391 4.03 -0.117 1.47 0.937 0.028 0.89 0.0411 2600000 2 2.86 0.485 0.314 7.36 0.0877 3490 0.47 2.07 0.82 0.086 1.6 0.0444 195 PRS_PLINK_1.99526231496888e.08 TRUE 282 Hereditary hemolytic anemias Both 16 53 4 hematopoietic darkorange1 53, 16 7, 2 13, 2 12, 1 13, 8 0.203 0.233 0.385 0.415 1.22 0.834 2.06 -0.235 1.17 0.841 0.075 0.791 0.0477 8.2 -0.641 1.21 0.596 0.225 0.527 0.0365 4.35 0.788 1.1 0.475 0.324 2.2 0.311 23 PRS_PLINK_1.99526231496888e.08 TRUE 282.8 Other hemoglobinopathies Both 13 33 4 hematopoietic darkorange1 33, 13 6, 2 9, 2 7, 2 8, 4 -0.134 0.396 0.734 0.134 0.874 0.351 1.69 -0.0369 1.53 0.981 0.008 0.964 0.041 19.6 -1.3 1.68 0.437 0.359 0.272 0.000188 3.09 -1.64 2.61 0.529 0.276 0.193 0.000256 48.8 PRS_PLINK_1.99526231496888e.08 TRUE 282.9 Other hereditary hemolytic anemias Both 9 27 4 hematopoietic darkorange1 27, 9 4, 2 7, 0 6, 1 7, 3 -1.04 0.767 0.177 0.752 0.355 0.0516 1.26 -1.16 1.89 0.538 0.269 0.312 0.00276 6.52 -2.24 2.29 0.328 0.484 0.106 0.00102 3.44 0.0903 1.34 0.946 0.024 1.09 0.13 12.1 PRS_PLINK_1.99526231496888e.08 TRUE 283 Acquired hemolytic anemias Both 4 38 4 hematopoietic darkorange1 38, 4 4, 0 10, 1 8, 1 10, 2 1.38 0.969 0.153 0.815 3.99 0.647 3270000 0.00436 2.13 0.998 0.001 1 0.0129 1650 1.59 2.24 0.48 0.319 4.88 0.161 1070 0.9 1.81 0.619 0.208 2.46 0.0973 406 PRS_PLINK_1.99526231496888e.08 TRUE 283.1 Autoimmune hemolytic anemias Both 2 12 4 hematopoietic darkorange1 12, 2 3, 0 4, 1 2, 1 3, 0 0.715 1.06 0.499 0.302 2.04 0.424 19.5 PRS_PLINK_1.99526231496888e.08 TRUE 284 Aplastic anemia Both 27 139 4 hematopoietic darkorange1 139, 27 17, 2 42, 9 26, 6 35, 8 0.255 0.16 0.11 0.957 1.29 0.958 1.74 1.4 1.03 0.174 0.76 4.07 0.649 55.3 0.619 0.929 0.505 0.296 1.86 0.335 18.6 0.949 0.865 0.272 0.565 2.58 0.543 17.7 PRS_PLINK_1.99526231496888e.08 TRUE 284.1 Pancytopenia Both 23 121 4 hematopoietic darkorange1 121, 23 13, 2 42, 7 18, 5 30, 7 0.0902 0.222 0.685 0.164 1.09 0.673 1.62 0.212 1.02 0.836 0.078 1.24 0.18 16 1.03 1.19 0.387 0.412 2.79 0.283 58.1 0.691 0.952 0.468 0.33 2 0.359 15 PRS_PLINK_1.99526231496888e.08 TRUE 285 Other anemias Both 471 733 4 hematopoietic darkorange1 733, 471 113, 81 227, 155 134, 69 183, 114 -0.0145 0.0615 0.814 0.089 0.986 0.872 1.11 -0.0946 0.185 0.61 0.215 0.91 0.634 1.31 -0.307 0.213 0.151 0.821 0.736 0.486 1.11 -0.143 0.192 0.457 0.34 0.867 0.597 1.26 PRS_PLINK_1.99526231496888e.08 FALSE 285.1 Acute posthemorrhagic anemia Both 102 535 4 hematopoietic darkorange1 535, 102 79, 14 180, 34 85, 13 133, 30 0.108 0.0959 0.262 0.581 1.11 0.916 1.33 0.0298 0.346 0.931 0.031 1.03 0.53 2.08 -0.117 0.418 0.779 0.109 0.889 0.387 2.03 0.291 0.356 0.414 0.382 1.34 0.675 2.76 PRS_PLINK_1.99526231496888e.08 FALSE 285.2 Anemia of chronic disease Both 56 337 4 hematopoietic darkorange1 337, 56 52, 8 109, 19 56, 8 84, 14 0.0589 0.127 0.642 0.193 1.06 0.803 1.33 0.136 0.45 0.762 0.118 1.15 0.485 2.91 0.023 0.542 0.966 0.015 1.02 0.346 3.05 0.0932 0.474 0.844 0.074 1.1 0.436 2.91 PRS_PLINK_1.99526231496888e.08 FALSE 285.21 Anemia in chronic kidney disease Both 23 145 4 hematopoietic darkorange1 145, 23 20, 2 52, 7 20, 5 36, 5 -0.06 0.242 0.805 0.094 0.942 0.506 1.38 0.276 0.801 0.73 0.137 1.32 0.298 8.06 0.826 0.855 0.334 0.477 2.29 0.469 18.2 0.492 0.945 0.602 0.22 1.64 0.256 17.4 PRS_PLINK_1.99526231496888e.08 TRUE 285.22 Anemia in neoplastic disease Both 20 116 4 hematopoietic darkorange1 116, 20 11, 2 30, 6 29, 5 28, 4 -0.0989 0.322 0.759 0.12 0.906 0.478 1.72 0.387 1.07 0.718 0.144 1.47 0.221 16.4 -0.142 1.07 0.894 0.048 0.868 0.0944 7.73 -0.0571 1.09 0.958 0.019 0.944 0.122 8.17 PRS_PLINK_1.99526231496888e.08 TRUE 286 Coagulation defects Both 143 826 4 hematopoietic darkorange1 826, 143 119, 17 284, 44 129, 26 205, 42 0.173 0.075 0.021 1.678 1.19 1.03 1.37 0.159 0.314 0.614 0.212 1.17 0.642 2.23 0.248 0.336 0.462 0.335 1.28 0.665 2.51 0.331 0.31 0.286 0.544 1.39 0.766 2.62 PRS_PLINK_1.99526231496888e.08 FALSE 286.1 Congenital coagulation defects Both 13 74 4 hematopoietic darkorange1 74, 13 15, 3 22, 2 13, 4 19, 3 0.273 0.48 0.569 0.245 1.31 0.512 3.62 -1.51 1.09 0.166 0.78 0.222 0.0111 1.66 -0.451 0.995 0.65 0.187 0.637 0.0916 3.98 -1.07 1.14 0.35 0.456 0.344 0.0214 3 PRS_PLINK_1.99526231496888e.08 TRUE 286.11 Von willebrand's disease Both 4 28 4 hematopoietic darkorange1 28, 4 3, 0 7, 1 7, 1 7, 2 0.853 0.806 0.29 0.538 2.35 0.514 15.2 0.0983 5.12 0.985 0.007 1.1 6.14e-06 4610 0.833 2.45 0.734 0.134 2.3 0.0601 2.69 0.656 2.59 0.8 0.097 1.93 0.0163 11400 PRS_PLINK_1.99526231496888e.08 TRUE 286.12 Congenital deficiency of other clotting factors (including factor VII) Both 7 35 4 hematopoietic darkorange1 35, 7 9, 2 9, 2 8, 2 9, 0 -1.16 0.828 0.163 0.787 0.315 0.0343 1.41 -1.67 2.06 0.419 0.377 0.189 1.31e-05 25.2 -0.395 1.52 0.795 0.099 0.674 0.0163 11.2 -1.11 1.76 0.527 0.278 0.328 0.000443 11.9 PRS_PLINK_1.99526231496888e.08 TRUE 286.2 Encounter for long-term (current) use of anticoagulants Both 90 483 4 hematopoietic darkorange1 483, 90 72, 16 169, 27 71, 13 120, 25 0.0461 0.155 0.767 0.115 1.05 0.773 1.43 -0.395 0.352 0.261 0.584 0.673 0.341 1.36 -0.242 0.417 0.561 0.251 0.785 0.345 1.76 -0.0988 0.357 0.782 0.107 0.906 0.453 1.85 PRS_PLINK_1.99526231496888e.08 FALSE 286.3 Coagulation defects complicating pregnancy or postpartum Female 24 79 4 hematopoietic darkorange1 79, 24 13, 3 20, 6 19, 7 20, 5 -0.0911 0.332 0.783 0.106 0.913 0.48 1.72 0.412 0.858 0.631 0.2 1.51 0.32 9.32 0.24 0.906 0.792 0.102 1.27 0.229 8.79 -0.157 0.889 0.86 0.066 0.855 0.159 4.8 PRS_PLINK_1.99526231496888e.08 TRUE 286.4 Acquired coagulation factor deficiency Both 4 53 4 hematopoietic darkorange1 53, 4 5, 0 16, 3 10, 0 13, 1 0.238 0.513 0.642 0.192 1.27 0.445 4.29 -1.06 2.28 0.641 0.193 0.345 0.00223 311 0.848 1.61 0.599 0.223 2.33 0.182 89.7 PRS_PLINK_1.99526231496888e.08 TRUE 286.5 Hemorrhagic disorder due to intrinsic circulating anticoagulants Both 6 20 4 hematopoietic darkorange1 20, 6 3, 2 7, 3 3, 0 5, 1 0.154 0.841 0.854 0.068 1.17 0.249 10.8 -0.588 2.05 0.775 0.111 0.555 0.00561 17.3 0.0114 23 1 0 1.01 0.933 1.07 0.0708 2.23 0.975 0.011 1.07 0.987 95.6 PRS_PLINK_1.99526231496888e.08 TRUE 286.6 Defibrination syndrome Both 95 597 4 hematopoietic darkorange1 597, 95 85, 14 204, 28 96, 17 146, 26 0.133 0.0974 0.171 0.768 1.14 0.934 1.36 -0.289 0.358 0.419 0.378 0.749 0.374 1.54 0.052 0.389 0.894 0.049 1.05 0.493 2.28 -0.034 0.355 0.924 0.034 0.967 0.487 1.98 PRS_PLINK_1.99526231496888e.08 FALSE 286.7 Other and unspecified coagulation defects Both 118 704 4 hematopoietic darkorange1 704, 118 102, 15 246, 36 108, 22 174, 34 0.171 0.0909 0.06 1.222 1.19 0.992 1.41 -0.0361 0.331 0.913 0.039 0.965 0.51 1.9 0.252 0.363 0.488 0.312 1.29 0.636 2.65 0.251 0.328 0.445 0.352 1.28 0.683 2.51 PRS_PLINK_1.99526231496888e.08 FALSE 286.8 Hypercoagulable state Both 53 230 4 hematopoietic darkorange1 230, 53 33, 10 82, 13 32, 6 58, 17 0.124 0.207 0.548 0.261 1.13 0.757 1.71 -0.8 0.497 0.108 0.967 0.449 0.166 1.22 -0.429 0.586 0.464 0.333 0.651 0.198 1.97 0.0244 0.454 0.957 0.019 1.02 0.433 2.51 PRS_PLINK_1.99526231496888e.08 FALSE 286.81 Primary hypercoagulable state Both 51 230 4 hematopoietic darkorange1 230, 51 39, 10 75, 12 37, 6 58, 16 0.0177 0.214 0.934 0.03 1.02 0.669 1.56 -0.516 0.497 0.299 0.524 0.597 0.223 1.64 -0.515 0.592 0.385 0.414 0.598 0.177 1.87 0.118 0.455 0.796 0.099 1.13 0.471 2.78 PRS_PLINK_1.99526231496888e.08 FALSE 286.9 Abnormal coagulation profile Both 44 204 4 hematopoietic darkorange1 204, 44 21, 6 70, 12 32, 7 51, 11 0.124 0.165 0.451 0.345 1.13 0.812 1.54 -0.247 0.6 0.681 0.167 0.781 0.252 2.67 -0.396 0.744 0.594 0.226 0.673 0.152 2.85 -0.316 0.603 0.6 0.222 0.729 0.226 2.42 PRS_PLINK_1.99526231496888e.08 TRUE 287 Purpura and other hemorrhagic conditions Both 101 601 4 hematopoietic darkorange1 601, 101 92, 19 204, 27 95, 17 148, 27 -0.0193 0.126 0.878 0.057 0.981 0.757 1.24 -0.508 0.334 0.128 0.892 0.602 0.312 1.17 -0.275 0.373 0.462 0.335 0.76 0.361 1.58 -0.171 0.331 0.605 0.218 0.843 0.442 1.63 PRS_PLINK_1.99526231496888e.08 FALSE 287.1 Spontaneous ecchymoses Both 9 67 4 hematopoietic darkorange1 67, 9 8, 1 21, 2 12, 2 17, 3 0.263 0.498 0.598 0.223 1.3 0.482 4 -0.153 1.32 0.908 0.042 0.858 0.00934 13.3 -0.313 1.54 0.839 0.076 0.731 0.0267 12.4 -0.16 1.45 0.912 0.04 0.852 0.0339 19 PRS_PLINK_1.99526231496888e.08 TRUE 287.3 Thrombocytopenia Both 91 537 4 hematopoietic darkorange1 537, 91 82, 18 178, 22 89, 17 134, 24 -0.0513 0.132 0.696 0.157 0.95 0.723 1.22 -0.636 0.355 0.073 1.137 0.529 0.262 1.07 -0.265 0.384 0.49 0.31 0.767 0.357 1.62 -0.288 0.347 0.405 0.392 0.749 0.38 1.49 PRS_PLINK_1.99526231496888e.08 FALSE 287.31 Primary thrombocytopenia Both 17 135 4 hematopoietic darkorange1 135, 17 28, 4 31, 2 33, 4 34, 4 -0.3 0.337 0.373 0.428 0.741 0.382 1.45 -0.64 0.895 0.474 0.324 0.527 0.0704 3.44 -0.176 0.748 0.814 0.089 0.839 0.179 3.91 -0.334 0.766 0.663 0.178 0.716 0.139 3.46 PRS_PLINK_1.99526231496888e.08 TRUE 287.32 Secondary thrombocytopenia Both 18 118 4 hematopoietic darkorange1 118, 18 10, 4 32, 3 25, 5 30, 4 -0.072 0.241 0.766 0.116 0.931 0.483 1.36 -0.236 0.941 0.802 0.096 0.79 0.135 6.13 -0.234 0.932 0.802 0.096 0.791 0.137 5.27 -1.12 0.935 0.231 0.637 0.326 0.0473 1.85 PRS_PLINK_1.99526231496888e.08 TRUE 287.4 Qualitative platelet defects Both 3 28 4 hematopoietic darkorange1 28, 3 7, 0 7, 0 7, 3 7, 0 1.47 0.973 0.132 0.88 4.33 0.868 212 PRS_PLINK_1.99526231496888e.08 TRUE 288 Diseases of white blood cells Both 187 872 4 hematopoietic darkorange1 872, 187 122, 35 273, 68 162, 31 217, 37 0.0487 0.0772 0.528 0.277 1.05 0.893 1.21 -0.164 0.244 0.5 0.301 0.848 0.53 1.37 -0.529 0.282 0.0604 1.219 0.589 0.337 1.02 -0.509 0.265 0.0551 1.259 0.601 0.357 1.01 PRS_PLINK_1.99526231496888e.08 FALSE 288.1 Decreased white blood cell count Both 59 331 4 hematopoietic darkorange1 331, 59 49, 7 109, 22 57, 10 82, 15 0.219 0.14 0.118 0.929 1.24 0.985 1.73 0.476 0.487 0.328 0.484 1.61 0.645 4.4 0.223 0.517 0.667 0.176 1.25 0.449 3.67 0.3 0.514 0.559 0.253 1.35 0.5 3.94 PRS_PLINK_1.99526231496888e.08 FALSE 288.11 Neutropenia Both 41 227 4 hematopoietic darkorange1 227, 41 31, 4 71, 14 41, 8 57, 11 0.245 0.162 0.13 0.885 1.28 0.993 1.98 0.977 0.666 0.143 0.846 2.66 0.785 11.4 0.164 0.632 0.795 0.1 1.18 0.345 4.34 0.296 0.655 0.652 0.186 1.34 0.388 5.45 PRS_PLINK_1.99526231496888e.08 TRUE 288.2 Elevated white blood cell count Both 154 800 4 hematopoietic darkorange1 800, 154 115, 29 255, 61 142, 23 200, 29 0.00523 0.0934 0.955 0.02 1.01 0.825 1.19 -0.0491 0.262 0.851 0.07 0.952 0.575 1.6 -0.518 0.312 0.0968 1.014 0.596 0.319 1.09 -0.528 0.29 0.068 1.168 0.59 0.333 1.04 PRS_PLINK_1.99526231496888e.08 FALSE 288.3 Eosinophilia Both 6 39 4 hematopoietic darkorange1 39, 6 5, 1 13, 2 6, 3 10, 0 0.0107 0.667 0.987 0.006 1.01 0.176 5.17 -1.23 2.76 0.655 0.183 0.291 8.9e-06 78.7 0.83 1.85 0.653 0.185 2.29 0.0737 223 -0.569 1.61 0.723 0.141 0.566 0.00273 20.6 PRS_PLINK_1.99526231496888e.08 TRUE 289 Other diseases of blood and blood-forming organs Both 98 416 4 hematopoietic darkorange1 416, 98 53, 16 131, 33 79, 13 102, 23 -0.255 0.14 0.0673 1.172 0.775 0.588 1.02 -0.243 0.359 0.498 0.302 0.784 0.394 1.6 -0.511 0.417 0.221 0.655 0.6 0.262 1.36 -0.368 0.383 0.337 0.472 0.692 0.329 1.47 PRS_PLINK_1.99526231496888e.08 FALSE 289.3 Personal history of diseases of blood and blood-forming organs Both 64 247 4 hematopoietic darkorange1 247, 64 38, 13 75, 21 48, 6 62, 15 -0.45 0.186 0.0156 1.808 0.638 0.441 0.914 -0.283 0.429 0.509 0.293 0.753 0.329 1.75 -1.18 0.552 0.0333 1.478 0.309 0.0946 0.888 -0.372 0.445 0.403 0.395 0.689 0.29 1.64 PRS_PLINK_1.99526231496888e.08 FALSE 289.4 Lymphadenitis Both 196 816 4 hematopoietic darkorange1 816, 196 119, 34 256, 69 149, 27 204, 48 0.02 0.0842 0.812 0.09 1.02 0.857 1.19 -0.0712 0.25 0.775 0.11 0.931 0.575 1.53 -0.508 0.286 0.0755 1.122 0.602 0.341 1.05 -0.172 0.26 0.508 0.294 0.842 0.508 1.41 PRS_PLINK_1.99526231496888e.08 FALSE 289.5 Diseases of spleen Both 13 96 4 hematopoietic darkorange1 96, 13 12, 2 26, 3 22, 3 24, 3 -0.385 0.436 0.378 0.423 0.681 0.272 1.62 -0.23 1.09 0.833 0.08 0.795 0.086 9.88 1.03 1.46 0.478 0.32 2.81 0.2 5480 -0.0825 1.13 0.942 0.026 0.921 0.0827 10.2 PRS_PLINK_1.99526231496888e.08 TRUE 289.8 Polycythemia, secondary Both 10 46 4 hematopoietic darkorange1 46, 10 10, 2 13, 4 9, 1 12, 2 -2.07 1.04 0.0467 1.33 0.126 0.00295 0.803 0.491 1.22 0.686 0.164 1.63 0.139 45.4 -0.268 1.64 0.871 0.06 0.765 0.0126 31.2 -0.362 1.13 0.749 0.126 0.696 0.071 7.55 PRS_PLINK_1.99526231496888e.08 TRUE 289.9 Abnormality of red blood cells Both 21 76 4 hematopoietic darkorange1 76, 21 7, 0 28, 8 10, 4 19, 7 0.261 0.352 0.459 0.338 1.3 0.668 2.59 0.0695 1.57 0.965 0.016 1.07 0.0636 742 0.666 1.61 0.679 0.168 1.95 0.0791 2060 1.84 1.82 0.312 0.506 6.27 0.328 1660000 PRS_PLINK_1.99526231496888e.08 TRUE 290 Delirium dementia and amnestic and other cognitive disorders Both 22 152 5 mental disorders magenta 152, 22 21, 4 58, 8 18, 3 38, 6 -0.0473 0.301 0.875 0.058 0.954 0.524 1.76 -0.215 0.647 0.74 0.131 0.807 0.238 3.12 -0.561 0.851 0.51 0.293 0.571 0.0931 2.8 -0.415 0.705 0.556 0.255 0.66 0.159 2.74 PRS_PLINK_1.99526231496888e.08 TRUE 290.1 Dementias Both 13 49 5 mental disorders magenta 49, 13 8, 3 15, 5 9, 2 12, 3 -1.01 0.614 0.101 0.996 0.365 0.096 1.13 -0.294 0.962 0.76 0.119 0.745 0.127 4.09 -1.6 1.63 0.328 0.484 0.202 0.00246 3.3 -0.732 1.27 0.564 0.249 0.481 0.0252 5.09 PRS_PLINK_1.99526231496888e.08 TRUE 290.11 Alzheimer's disease Both 3 17 5 mental disorders magenta 17, 3 6, 3 3, 0 4, 0 3, 0 -1.94 1.73 0.261 0.583 0.143 1.23e-05 2.78 0.00521 2.71 0.998 0.001 1.01 0.000922 157 -0.536 1.91 0.779 0.109 0.585 0.48 12.4 -0.602 2.3 0.793 0.101 0.548 0.00134 26.9 PRS_PLINK_1.99526231496888e.08 TRUE 290.12 Dementia with cerebral degenerations Both 4 4 5 mental disorders magenta 4, 4 1, 1 2, 2 0, 1 1, 0 -0.0262 751 1 0 0.974 0.681 1.15 0.269 1550 1 0 1.31 0.468 4.87 -0.00707 47.7 1 0 0.993 0.925 1.06 0.0373 40.2 0.999 0 1.04 0.904 1.18 PRS_PLINK_1.99526231496888e.08 TRUE 290.13 Senile dementia Both 8 28 5 mental disorders magenta 28, 8 8, 4 5, 2 7, 1 7, 1 -1.39 1.01 0.168 0.775 0.249 0.00865 1.92 0.526 1.53 0.732 0.136 1.69 0.0824 45.2 -0.14 1.69 0.934 0.03 0.87 0.00272 19.2 -1.68 1.81 0.353 0.452 0.187 0.000133 3.69 PRS_PLINK_1.99526231496888e.08 TRUE 290.16 Vascular dementia Both 3 5 5 mental disorders magenta 5, 3 2, 1 1, 0 1, 1 1, 1 0.119 424 1 0 1.13 0.663 2.22 -0.147 7790 1 0 0.863 0.121 1.64 -0.309 15500 1 0 0.734 0.158 2.9 0.00135 273 1 0 1 0.882 1.15 PRS_PLINK_1.99526231496888e.08 TRUE 290.2 Delirium due to conditions classified elsewhere Both 12 111 5 mental disorders magenta 111, 12 16, 2 44, 4 11, 0 28, 5 0.0856 0.366 0.815 0.089 1.09 0.52 2.37 -0.398 0.833 0.632 0.199 0.671 0.129 4.42 -1.32 1.37 0.335 0.475 0.267 0.000538 3.31 0.308 0.842 0.715 0.146 1.36 0.27 8.78 PRS_PLINK_1.99526231496888e.08 TRUE 290.3 Other persistent mental disorders due to conditions classified elsewhere Both 40 175 5 mental disorders magenta 175, 40 28, 9 54, 10 32, 8 44, 10 0.0954 0.148 0.519 0.285 1.1 0.817 1.44 -0.524 0.533 0.326 0.487 0.592 0.209 1.68 -0.754 0.683 0.27 0.569 0.47 0.115 1.73 -0.417 0.554 0.451 0.346 0.659 0.219 1.94 PRS_PLINK_1.99526231496888e.08 TRUE 291 Other specified nonpsychotic and/or transient mental disorders Both 132 619 5 mental disorders magenta 619, 132 80, 21 210, 30 99, 23 155, 39 0.0678 0.0842 0.421 0.376 1.07 0.901 1.25 -0.604 0.316 0.0557 1.254 0.547 0.295 1.02 -0.122 0.347 0.725 0.14 0.885 0.449 1.75 -0.0611 0.308 0.843 0.074 0.941 0.519 1.74 PRS_PLINK_1.99526231496888e.08 FALSE 291.1 Transient mental disorders due to conditions classified elsewhere Both 31 121 5 mental disorders magenta 121, 31 19, 4 36, 7 24, 7 30, 10 0.0583 0.215 0.786 0.105 1.06 0.676 1.56 0.0722 0.705 0.918 0.037 1.07 0.28 4.57 0.834 0.827 0.313 0.504 2.3 0.493 12.5 0.487 0.72 0.499 0.302 1.63 0.425 7.05 PRS_PLINK_1.99526231496888e.08 TRUE 291.4 Specific nonpsychotic mental disorders due to brain damage Both 18 122 5 mental disorders magenta 122, 18 22, 4 36, 0 24, 5 31, 6 0.212 0.171 0.214 0.669 1.24 0.897 1.7 -2.39 1.17 0.0404 1.394 0.0914 0.00104 0.887 -0.0137 0.869 0.987 0.006 0.986 0.172 6.19 0.364 0.808 0.652 0.185 1.44 0.29 7.52 PRS_PLINK_1.99526231496888e.08 TRUE 291.8 Alteration of consciousness Both 94 438 5 mental disorders magenta 438, 94 59, 15 143, 24 77, 15 108, 23 -0.0794 0.113 0.482 0.317 0.924 0.721 1.13 -0.468 0.37 0.207 0.684 0.627 0.306 1.31 -0.128 0.42 0.76 0.119 0.88 0.386 2.01 -0.247 0.372 0.507 0.295 0.781 0.378 1.64 PRS_PLINK_1.99526231496888e.08 FALSE 292 Neurological disorders Both 213 930 5 mental disorders magenta 930, 213 129, 22 311, 85 153, 36 233, 52 0.0446 0.0757 0.556 0.255 1.05 0.894 1.2 0.39 0.266 0.143 0.845 1.48 0.889 2.53 0.295 0.299 0.324 0.489 1.34 0.752 2.44 0.212 0.284 0.456 0.341 1.24 0.714 2.19 PRS_PLINK_1.99526231496888e.08 FALSE 292.1 Aphasia/speech disturbance Both 50 374 5 mental disorders magenta 374, 50 52, 7 95, 16 90, 14 94, 10 0.108 0.116 0.348 0.459 1.11 0.861 1.36 0.254 0.488 0.603 0.22 1.29 0.503 3.57 0.203 0.501 0.684 0.165 1.23 0.463 3.57 -0.315 0.516 0.542 0.266 0.73 0.254 2.14 PRS_PLINK_1.99526231496888e.08 TRUE 292.11 Aphasia Both 13 132 5 mental disorders magenta 132, 13 17, 1 35, 1 31, 3 33, 6 0.336 0.244 0.169 0.771 1.4 0.966 3.3 -1.2 1.35 0.375 0.426 0.301 0.00213 8.13 2.52 2.02 0.212 0.674 12.4 0.0761 92800 3.9 2.06 0.0578 1.238 49.5 1.37 728000 PRS_PLINK_1.99526231496888e.08 TRUE 292.12 Symbolic dysfunction Both 12 32 5 mental disorders magenta 32, 12 3, 1 11, 5 5, 2 8, 4 0.358 0.318 0.261 0.584 1.43 0.898 5.18 2.41 2.16 0.265 0.577 11.2 0.49 6120 -0.678 2.56 0.791 0.102 0.508 0.000577 68.8 1.45 2.71 0.594 0.226 4.24 0.0362 5730 PRS_PLINK_1.99526231496888e.08 TRUE 292.2 Mild cognitive impairment Both 12 53 5 mental disorders magenta 53, 12 6, 2 18, 6 8, 0 13, 3 0.0115 0.443 0.979 0.009 1.01 0.424 2.41 0.184 1.08 0.865 0.063 1.2 0.178 9.91 -1.54 2.04 0.45 0.346 0.215 6.76e-06 8.06 0.374 1.29 0.772 0.112 1.45 0.154 36.9 PRS_PLINK_1.99526231496888e.08 TRUE 292.3 Memory loss Both 93 359 5 mental disorders magenta 359, 93 50, 12 120, 33 58, 15 90, 28 0.106 0.141 0.452 0.344 1.11 0.842 1.46 -0.0642 0.387 0.868 0.061 0.938 0.449 2.04 -0.00412 0.433 0.992 0.003 0.996 0.425 2.35 0.152 0.405 0.707 0.151 1.16 0.535 2.63 PRS_PLINK_1.99526231496888e.08 FALSE 292.4 Altered mental status Both 69 405 5 mental disorders magenta 405, 69 56, 8 139, 25 62, 11 101, 20 0.0913 0.134 0.495 0.305 1.1 0.827 1.4 0.196 0.434 0.651 0.186 1.22 0.534 3.01 0.239 0.49 0.626 0.203 1.27 0.485 3.44 0.283 0.445 0.524 0.281 1.33 0.565 3.34 PRS_PLINK_1.99526231496888e.08 FALSE 292.5 Transient alteration of awareness Both 16 105 5 mental disorders magenta 105, 16 22, 1 36, 8 16, 2 26, 3 -0.162 0.263 0.538 0.269 0.851 0.393 1.29 1.21 0.887 0.174 0.759 3.34 0.645 33.9 1.33 1.26 0.293 0.534 3.78 0.282 3530 0.31 1 0.757 0.121 1.36 0.188 14.5 PRS_PLINK_1.99526231496888e.08 TRUE 292.6 Hallucinations Both 6 56 5 mental disorders magenta 56, 6 9, 2 16, 3 12, 0 14, 1 -0.489 0.529 0.355 0.45 0.613 0.187 1.91 -0.0861 1.05 0.935 0.029 0.917 0.132 7.31 -0.709 1.42 0.617 0.21 0.492 0.000155 6.62 -0.724 1.19 0.542 0.266 0.485 0.00177 4.36 PRS_PLINK_1.99526231496888e.08 TRUE 293 Symptoms involving head and neck Both 28 113 5 mental disorders magenta 113, 28 17, 6 35, 10 22, 2 27, 8 -0.103 0.221 0.641 0.193 0.902 0.503 1.28 0.0566 0.637 0.929 0.032 1.06 0.331 3.68 -1.9 1.28 0.137 0.862 0.15 0.00222 1.65 -0.227 0.676 0.737 0.132 0.797 0.218 2.99 PRS_PLINK_1.99526231496888e.08 TRUE 293.1 Swelling, mass, or lump in head and neck [Space-occupying lesion, intracranial NOS] Both 197 958 5 mental disorders magenta 958, 197 141, 35 318, 61 161, 25 238, 57 0.0125 0.0768 0.871 0.06 1.01 0.861 1.17 -0.342 0.244 0.161 0.794 0.71 0.442 1.15 -0.525 0.289 0.0691 1.161 0.592 0.333 1.04 -0.0168 0.245 0.946 0.024 0.983 0.611 1.6 PRS_PLINK_1.99526231496888e.08 FALSE 295 Schizophrenia and other psychotic disorders Both 32 88 5 mental disorders magenta 88, 32 11, 7 27, 12 17, 6 21, 5 -0.284 0.259 0.272 0.566 0.753 0.417 1.16 -0.469 0.661 0.477 0.321 0.625 0.181 2.12 -1.21 0.856 0.156 0.808 0.297 0.0545 1.27 -1.1 0.804 0.17 0.77 0.332 0.0684 1.38 PRS_PLINK_1.99526231496888e.08 TRUE 295.1 Schizophrenia Both 5 20 5 mental disorders magenta 20, 5 2, 0 5, 2 5, 2 5, 1 -1.25 1.21 0.3 0.523 0.285 5.79e-06 2.26 0.153 4.73 0.974 0.011 1.17 0.000622 1710 2.5 3110000 1 0 12.2 1.31 314 0.0021 261 1 0 1 0.0129 8.76 PRS_PLINK_1.99526231496888e.08 TRUE 295.2 Paranoid disorders Both 6 21 5 mental disorders magenta 21, 6 3, 1 7, 2 3, 1 5, 2 0.177 0.576 0.758 0.12 1.19 0.438 3.83 -3.44 11.3 0.762 0.118 0.0322 6.01e-11 38300000 4.61 121 0.97 0.013 101 0.0741 161000 -1.49 3.31 0.652 0.186 0.225 0.19 0.334 PRS_PLINK_1.99526231496888e.08 TRUE 295.3 Psychosis Both 28 76 5 mental disorders magenta 76, 28 10, 8 23, 8 15, 4 19, 6 -0.216 0.248 0.383 0.417 0.806 0.424 1.19 -0.678 0.707 0.337 0.472 0.508 0.133 1.84 -1.46 1.18 0.215 0.667 0.231 0.0188 1.82 -1.12 0.795 0.161 0.794 0.328 0.0644 1.35 PRS_PLINK_1.99526231496888e.08 TRUE 296 Mood disorders Both 687 263 5 mental disorders magenta 263, 687 35, 105 80, 226 51, 121 65, 166 0.00821 0.0754 0.913 0.039 1.01 0.875 1.17 -0.173 0.241 0.473 0.325 0.841 0.521 1.34 -0.28 0.268 0.297 0.528 0.756 0.446 1.27 -0.206 0.249 0.409 0.388 0.814 0.498 1.32 PRS_PLINK_1.99526231496888e.08 FALSE 296.1 Bipolar Both 84 218 5 mental disorders magenta 218, 84 26, 11 73, 31 36, 4 54, 26 -0.0862 0.14 0.538 0.27 0.917 0.687 1.18 -0.186 0.454 0.681 0.167 0.83 0.351 2.02 -1.32 0.687 0.0552 1.258 0.268 0.0615 0.955 -0.0707 0.473 0.881 0.055 0.932 0.377 2.34 PRS_PLINK_1.99526231496888e.08 FALSE 296.2 Depression Both 666 263 5 mental disorders magenta 263, 666 35, 102 80, 220 51, 116 65, 162 0.016 0.076 0.833 0.079 1.02 0.881 1.18 -0.146 0.243 0.547 0.262 0.864 0.534 1.38 -0.293 0.27 0.278 0.556 0.746 0.439 1.26 -0.194 0.251 0.439 0.358 0.823 0.502 1.33 PRS_PLINK_1.99526231496888e.08 FALSE 296.22 Major depressive disorder Both 623 263 5 mental disorders magenta 263, 623 35, 92 80, 209 51, 106 65, 152 -0.00247 0.0792 0.975 0.011 0.998 0.859 1.17 -0.0883 0.245 0.718 0.144 0.915 0.564 1.46 -0.281 0.274 0.304 0.518 0.755 0.442 1.28 -0.149 0.255 0.56 0.252 0.862 0.522 1.41 PRS_PLINK_1.99526231496888e.08 FALSE 297 Suicidal ideation or attempt Both 56 180 5 mental disorders magenta 180, 56 26, 11 60, 21 30, 6 45, 12 -0.197 0.179 0.27 0.568 0.821 0.558 1.13 -0.255 0.485 0.598 0.223 0.775 0.309 1.99 -1.14 0.641 0.0752 1.124 0.32 0.0819 1.02 -0.558 0.538 0.299 0.524 0.572 0.201 1.59 PRS_PLINK_1.99526231496888e.08 FALSE 297.1 Suicidal ideation Both 46 146 5 mental disorders magenta 146, 46 22, 8 50, 15 22, 6 37, 11 -0.192 0.224 0.391 0.408 0.825 0.533 1.27 -0.253 0.56 0.652 0.186 0.777 0.269 2.31 -0.806 0.729 0.269 0.571 0.446 0.097 1.69 -0.421 0.595 0.48 0.319 0.657 0.206 2.04 PRS_PLINK_1.99526231496888e.08 TRUE 297.2 Suicide or self-inflicted injury Both 15 66 5 mental disorders magenta 66, 15 9, 2 17, 8 16, 0 16, 4 -0.0667 0.355 0.851 0.07 0.935 0.465 1.93 0.479 0.949 0.614 0.212 1.61 0.305 11 -0.729 1.29 0.572 0.243 0.482 0.00668 10.1 -0.119 1.13 0.915 0.038 0.887 0.0938 7.31 PRS_PLINK_1.99526231496888e.08 TRUE 300 Anxiety disorders Both 740 263 5 mental disorders magenta 263, 740 35, 119 80, 230 51, 134 65, 172 -0.0109 0.0692 0.874 0.058 0.989 0.868 1.14 -0.225 0.237 0.341 0.467 0.798 0.499 1.26 -0.266 0.259 0.303 0.518 0.766 0.461 1.26 -0.283 0.246 0.25 0.602 0.754 0.464 1.21 PRS_PLINK_1.99526231496888e.08 FALSE 300.1 Anxiety disorder Both 693 263 5 mental disorders magenta 263, 693 35, 112 80, 213 51, 123 65, 164 -0.0073 0.0691 0.916 0.038 0.993 0.872 1.14 -0.243 0.239 0.31 0.509 0.784 0.488 1.24 -0.305 0.262 0.244 0.612 0.737 0.44 1.22 -0.283 0.249 0.255 0.594 0.753 0.461 1.22 PRS_PLINK_1.99526231496888e.08 FALSE 300.11 Generalized anxiety disorder Both 368 263 5 mental disorders magenta 263, 368 35, 61 80, 107 51, 57 65, 98 0.0318 0.0749 0.671 0.173 1.03 0.896 1.2 -0.264 0.269 0.326 0.486 0.768 0.455 1.29 -0.519 0.307 0.091 1.041 0.595 0.328 1.07 -0.238 0.281 0.397 0.401 0.788 0.456 1.35 PRS_PLINK_1.99526231496888e.08 FALSE 300.12 Agorophobia, social phobia, and panic disorder Both 99 217 5 mental disorders magenta 217, 99 27, 19 71, 33 37, 12 54, 23 0.0363 0.118 0.758 0.121 1.04 0.814 1.28 -0.172 0.408 0.672 0.172 0.842 0.389 1.85 -1.02 0.502 0.0426 1.37 0.362 0.134 0.911 -0.376 0.431 0.383 0.416 0.687 0.302 1.56 PRS_PLINK_1.99526231496888e.08 FALSE 300.13 Phobia Both 65 157 5 mental disorders magenta 157, 65 24, 10 47, 24 31, 7 38, 18 -0.00727 0.205 0.972 0.012 0.993 0.669 1.48 0.245 0.502 0.626 0.204 1.28 0.505 3.38 -0.679 0.658 0.302 0.52 0.507 0.14 1.71 0.114 0.554 0.837 0.077 1.12 0.389 3.28 PRS_PLINK_1.99526231496888e.08 FALSE 300.3 Obsessive-compulsive disorders Both 31 80 5 mental disorders magenta 80, 31 13, 8 23, 10 17, 4 20, 7 -0.135 0.219 0.536 0.271 0.873 0.524 1.26 -0.298 0.639 0.641 0.193 0.742 0.223 2.45 -1.02 0.901 0.26 0.586 0.362 0.058 2.27 -0.963 0.806 0.232 0.634 0.382 0.0625 1.68 PRS_PLINK_1.99526231496888e.08 TRUE 300.4 Dysthymic disorder Both 175 243 5 mental disorders magenta 243, 175 30, 30 78, 60 43, 23 61, 44 0.0726 0.0965 0.452 0.345 1.08 0.896 1.3 -0.375 0.333 0.26 0.585 0.687 0.362 1.3 -0.684 0.402 0.0886 1.053 0.504 0.231 1.07 -0.361 0.344 0.293 0.533 0.697 0.36 1.34 PRS_PLINK_1.99526231496888e.08 FALSE 300.8 Acute reaction to stress Both 37 85 5 mental disorders magenta 85, 37 15, 7 23, 9 19, 9 21, 5 -0.237 0.246 0.335 0.475 0.789 0.459 1.2 0.459 0.716 0.521 0.283 1.58 0.437 6.68 -0.913 0.851 0.284 0.547 0.401 0.0636 1.84 -0.0973 0.815 0.905 0.043 0.907 0.187 4.53 PRS_PLINK_1.99526231496888e.08 TRUE 300.9 Posttraumatic stress disorder Both 56 169 5 mental disorders magenta 169, 56 27, 10 59, 20 23, 9 42, 12 -0.0289 0.183 0.874 0.058 0.972 0.651 1.34 -0.0947 0.484 0.845 0.073 0.91 0.365 2.36 -0.168 0.659 0.799 0.098 0.845 0.233 2.92 -0.205 0.54 0.704 0.153 0.814 0.262 2.33 PRS_PLINK_1.99526231496888e.08 FALSE 301 Personality disorders Both 41 113 5 mental disorders magenta 113, 41 15, 9 37, 13 19, 4 28, 12 -0.134 0.2 0.502 0.299 0.875 0.56 1.23 -0.917 0.639 0.151 0.821 0.4 0.115 1.31 -1.11 0.943 0.24 0.62 0.33 0.0456 1.82 -1.06 0.665 0.111 0.953 0.347 0.0898 1.19 PRS_PLINK_1.99526231496888e.08 TRUE 301.2 Antisocial/borderline personality disorder Both 26 73 5 mental disorders magenta 73, 26 11, 6 22, 9 14, 1 18, 7 -0.284 0.285 0.319 0.496 0.753 0.429 1.3 -0.603 0.791 0.446 0.351 0.547 0.112 2.36 -2.86 2 0.152 0.818 0.0573 6.44e-06 2.01 -0.96 0.81 0.236 0.627 0.383 0.0733 1.65 PRS_PLINK_1.99526231496888e.08 TRUE 302 Sexual and gender identity disorders Both 217 151 5 mental disorders magenta 151, 217 21, 34 48, 75 28, 39 37, 48 -0.121 0.141 0.388 0.411 0.886 0.673 1.16 -0.237 0.379 0.532 0.274 0.789 0.377 1.62 -0.435 0.434 0.316 0.5 0.647 0.276 1.47 -0.411 0.385 0.286 0.543 0.663 0.313 1.37 PRS_PLINK_1.99526231496888e.08 FALSE 302.1 Decreased libido Both 80 67 5 mental disorders magenta 67, 80 13, 18 21, 23 12, 15 17, 19 -0.335 0.281 0.233 0.633 0.716 0.411 1.22 -0.0404 0.591 0.945 0.024 0.96 0.309 2.99 -0.621 0.743 0.403 0.394 0.538 0.123 2.08 -0.521 0.604 0.388 0.411 0.594 0.178 1.82 PRS_PLINK_1.99526231496888e.08 FALSE 303 Psychogenic and somatoform disorders Both 325 258 5 mental disorders magenta 258, 325 35, 48 78, 119 49, 58 65, 73 0.0455 0.0873 0.602 0.22 1.05 0.885 1.24 -0.115 0.299 0.701 0.154 0.891 0.497 1.58 -0.221 0.319 0.489 0.311 0.802 0.431 1.48 -0.338 0.308 0.273 0.564 0.713 0.391 1.29 PRS_PLINK_1.99526231496888e.08 FALSE 303.1 Dissociative disorder Both 8 37 5 mental disorders magenta 37, 8 6, 4 10, 2 10, 0 7, 2 0.273 0.347 0.431 0.365 1.31 0.275 4.04 -0.428 1.16 0.711 0.148 0.652 0.07 63.7 0.0588 2.1 0.978 0.01 1.06 0.000182 1080 0.552 1.54 0.72 0.143 1.74 0.00218 116 PRS_PLINK_1.99526231496888e.08 TRUE 303.3 Psychogenic disorder Both 305 259 5 mental disorders magenta 259, 305 35, 47 79, 109 49, 52 65, 70 0.0682 0.0886 0.442 0.355 1.07 0.903 1.27 -0.253 0.309 0.412 0.385 0.776 0.424 1.4 -0.32 0.328 0.33 0.482 0.726 0.384 1.36 -0.32 0.31 0.303 0.518 0.727 0.397 1.32 PRS_PLINK_1.99526231496888e.08 FALSE 303.31 Gastrointestinal malfunction arising from mental factors Both 29 63 5 mental disorders magenta 63, 29 12, 7 18, 6 12, 4 16, 10 0.338 0.319 0.291 0.537 1.4 0.776 2.62 -0.555 0.811 0.493 0.307 0.574 0.11 2.58 -1.01 0.959 0.29 0.537 0.363 0.0484 1.88 0.834 0.856 0.33 0.482 2.3 0.484 13.2 PRS_PLINK_1.99526231496888e.08 TRUE 303.4 Somatoform disorder Both 65 202 5 mental disorders magenta 202, 65 26, 12 61, 23 39, 11 51, 15 -0.0896 0.174 0.606 0.218 0.914 0.632 1.25 -0.171 0.48 0.722 0.142 0.843 0.338 2.16 -0.382 0.512 0.455 0.342 0.682 0.252 1.8 -0.482 0.529 0.362 0.441 0.617 0.216 1.71 PRS_PLINK_1.99526231496888e.08 FALSE 304 Adjustment reaction Both 244 261 5 mental disorders magenta 261, 244 35, 38 79, 79 50, 46 65, 59 0.0413 0.0946 0.663 0.179 1.04 0.867 1.25 0.0327 0.302 0.914 0.039 1.03 0.579 1.85 -0.186 0.341 0.586 0.232 0.831 0.431 1.6 -0.206 0.313 0.51 0.293 0.814 0.445 1.48 PRS_PLINK_1.99526231496888e.08 FALSE 305.2 Eating disorder Both 81 180 5 mental disorders magenta 180, 81 28, 16 58, 27 33, 14 44, 16 0.0044 0.131 0.973 0.012 1 0.77 1.28 -0.0905 0.438 0.836 0.078 0.914 0.4 2.14 0.0418 0.495 0.933 0.03 1.04 0.408 2.7 -0.487 0.461 0.291 0.537 0.615 0.255 1.46 PRS_PLINK_1.99526231496888e.08 FALSE 306 Other mental disorder Both 151 237 5 mental disorders magenta 237, 151 30, 19 75, 51 43, 31 59, 36 0.137 0.0979 0.162 0.791 1.15 0.958 1.4 -0.0978 0.369 0.791 0.102 0.907 0.449 1.85 0.141 0.397 0.723 0.141 1.15 0.544 2.47 -0.117 0.378 0.757 0.121 0.89 0.435 1.84 PRS_PLINK_1.99526231496888e.08 FALSE 306.1 Mental disorders durring/after pregnancy Female 128 158 5 mental disorders magenta 158, 128 22, 29 49, 28 30, 24 39, 32 -0.0225 0.114 0.843 0.074 0.978 0.785 1.21 -1.08 0.405 0.00763 2.118 0.339 0.153 0.725 -0.738 0.46 0.109 0.964 0.478 0.192 1.14 -0.653 0.398 0.101 0.997 0.521 0.241 1.1 PRS_PLINK_1.99526231496888e.08 FALSE 306.9 Tension headache Both 73 156 5 mental disorders magenta 156, 73 23, 18 43, 18 37, 14 37, 17 0.115 0.117 0.325 0.487 1.12 0.898 1.4 -0.688 0.467 0.141 0.85 0.503 0.204 1.22 -0.653 0.484 0.177 0.752 0.52 0.207 1.29 -0.728 0.516 0.158 0.801 0.483 0.176 1.26 PRS_PLINK_1.99526231496888e.08 FALSE 312 Conduct disorders Both 17 53 5 mental disorders magenta 53, 17 5, 4 13, 8 14, 0 12, 2 -0.788 0.419 0.06 1.222 0.455 0.187 0.974 -0.612 1.01 0.544 0.264 0.542 0.0298 3.29 -2.52 1.63 0.122 0.913 0.0808 1.07e-05 1.12 -2.89 1.69 0.087 1.06 0.0556 0.000101 0.799 PRS_PLINK_1.99526231496888e.08 TRUE 312.3 Impulse control disorder Both 8 23 5 mental disorders magenta 23, 8 3, 2 6, 5 5, 0 6, 1 -2.01 1.45 0.168 0.776 0.134 0.000765 1.63 2.31 2.52 0.359 0.444 10.1 0.267 2630 0.198 5.92 0.973 0.012 1.22 1.58e-06 24600 0.696 3.89 0.858 0.066 2.01 8.31e-05 4220 PRS_PLINK_1.99526231496888e.08 TRUE 313 Pervasive developmental disorders Both 107 488 5 mental disorders magenta 488, 107 72, 12 157, 37 85, 17 122, 25 -0.082 0.112 0.463 0.334 0.921 0.726 1.13 0.344 0.365 0.345 0.462 1.41 0.705 2.98 0.0825 0.428 0.847 0.072 1.09 0.472 2.55 0.208 0.39 0.593 0.227 1.23 0.58 2.72 PRS_PLINK_1.99526231496888e.08 FALSE 313.1 Attention deficit hyperactivity disorder Both 99 449 5 mental disorders magenta 449, 99 68, 12 145, 32 76, 15 112, 25 -0.0568 0.111 0.609 0.216 0.945 0.746 1.16 0.169 0.375 0.653 0.185 1.18 0.578 2.54 0.05 0.448 0.911 0.04 1.05 0.439 2.56 0.152 0.394 0.699 0.156 1.16 0.544 2.59 PRS_PLINK_1.99526231496888e.08 FALSE 313.2 Tics and stuttering Both 3 19 5 mental disorders magenta 19, 3 3, 0 5, 0 4, 2 5, 0 -1.08 1.09 0.322 0.492 0.339 8.6e-06 2.48 0.378 10.6 0.972 0.013 1.46 2.4 2.39 PRS_PLINK_1.99526231496888e.08 TRUE 313.3 Autism Both 7 7 5 mental disorders magenta 7, 7 2, 2 2, 2 1, 3 2, 0 -2.25 2.6 0.387 0.412 0.105 5.22e-09 4.14 2.58 129 0.984 0.007 13.2 2.26 1010 -0.00867 631 1 0 0.991 0.264 1.46 -0.212 1670 1 0 0.809 0.739 2.19 PRS_PLINK_1.99526231496888e.08 TRUE 315 Develomental delays and disorders Both 22 160 5 mental disorders magenta 160, 22 20, 2 47, 5 33, 8 40, 5 0.0983 0.29 0.735 0.134 1.1 0.59 1.96 -0.977 0.887 0.27 0.568 0.376 0.039 2.44 0.317 0.801 0.692 0.16 1.37 0.291 8.05 -0.0431 0.773 0.955 0.02 0.958 0.21 5.28 PRS_PLINK_1.99526231496888e.08 TRUE 315.1 Learning disorder Both 1 28 5 mental disorders magenta 28, 1 3, 0 7, 1 7, 0 7, 0 -0.0464 0.776 0.952 0.021 0.955 0.104 7.69 -1.23e-15 3.47 1 0 1 0.00359 276 PRS_PLINK_1.99526231496888e.08 TRUE 315.2 Speech and language disorder Both 4 73 5 mental disorders magenta 73, 4 5, 0 18, 0 18, 1 18, 2 0.371 0.54 0.492 0.308 1.45 0.432 5.77 -1.41 2.85 0.619 0.208 0.243 2.13e-05 172 1.08 1.81 0.552 0.258 2.94 0.044 646 PRS_PLINK_1.99526231496888e.08 TRUE 316 Substance addiction and disorders Both 145 861 5 mental disorders magenta 861, 145 132, 21 289, 43 137, 25 214, 44 0.0911 0.0793 0.251 0.601 1.1 0.929 1.27 -0.0797 0.29 0.783 0.106 0.923 0.526 1.66 0.198 0.326 0.543 0.265 1.22 0.642 2.34 0.21 0.291 0.471 0.327 1.23 0.701 2.22 PRS_PLINK_1.99526231496888e.08 FALSE 316.1 Polyneuropathy due to drugs Both 21 169 5 mental disorders magenta 169, 21 23, 5 62, 6 23, 3 41, 3 -0.2 0.27 0.458 0.339 0.818 0.449 1.33 -0.613 0.63 0.33 0.481 0.541 0.159 1.93 -0.284 0.796 0.721 0.142 0.752 0.15 3.57 -0.992 0.747 0.184 0.735 0.371 0.0783 1.56 PRS_PLINK_1.99526231496888e.08 TRUE 317 Alcohol-related disorders Both 62 470 5 mental disorders magenta 470, 62 77, 6 147, 17 85, 17 118, 13 -0.123 0.168 0.464 0.333 0.884 0.626 1.23 0.263 0.46 0.568 0.246 1.3 0.529 3.58 1.16 0.504 0.0208 1.681 3.2 1.22 9.43 -0.0121 0.49 0.98 0.009 0.988 0.37 2.83 PRS_PLINK_1.99526231496888e.08 FALSE 317.1 Alcoholism Both 50 383 5 mental disorders magenta 383, 50 59, 4 123, 15 68, 14 95, 11 -0.0343 0.181 0.85 0.071 0.966 0.664 1.37 0.438 0.526 0.405 0.393 1.55 0.554 5.21 1.36 0.586 0.02 1.698 3.91 1.29 14.4 0.0717 0.564 0.899 0.046 1.07 0.343 3.79 PRS_PLINK_1.99526231496888e.08 TRUE 317.11 Alcoholic liver damage Both 4 65 5 mental disorders magenta 65, 4 11, 1 20, 0 12, 2 16, 1 0.0659 0.341 0.847 0.072 1.07 0.27 1.89 -1.12 1.27 0.378 0.422 0.325 0.00675 4.74 0.35 1.27 0.783 0.106 1.42 0.0957 32.4 -0.164 1.37 0.905 0.043 0.849 0.0462 751 PRS_PLINK_1.99526231496888e.08 TRUE 318 Tobacco use disorder Both 227 914 5 mental disorders magenta 914, 227 136, 38 306, 70 145, 37 229, 59 0.000576 0.0776 0.994 0.003 1 0.851 1.16 -0.253 0.235 0.282 0.55 0.777 0.492 1.24 -0.107 0.264 0.687 0.163 0.899 0.536 1.51 -0.0663 0.24 0.782 0.107 0.936 0.587 1.5 PRS_PLINK_1.99526231496888e.08 FALSE 320 Meningitis Both 12 107 6 neurological darkblue 107, 12 13, 0 28, 4 24, 3 27, 2 0.0953 0.205 0.642 0.193 1.1 0.47 1.48 2.53 1.96 0.198 0.704 12.6 0.439 81400 0.708 1.44 0.624 0.205 2.03 0.119 573 0.53 1.21 0.662 0.179 1.7 0.163 116 PRS_PLINK_1.99526231496888e.08 TRUE 323 Encephalitis Both 15 49 6 neurological darkblue 49, 15 8, 0 15, 3 9, 1 12, 9 0.624 0.443 0.159 0.799 1.87 0.835 4.77 1.43 1.84 0.436 0.36 4.18 0.1 85200 1.76 2.12 0.407 0.39 5.81 0.168 8490000 2.43 1.55 0.119 0.926 11.3 0.873 2760 PRS_PLINK_1.99526231496888e.08 TRUE 323.8 Encephalitis, non-infectious Both 14 41 6 neurological darkblue 41, 14 7, 0 13, 3 7, 1 10, 8 0.665 0.475 0.162 0.792 1.94 0.834 5.32 0.913 1.79 0.61 0.215 2.49 0.0926 1990 0.903 1.89 0.633 0.198 2.47 0.118 618 2.72 1.62 0.0938 1.028 15.2 0.986 2470 PRS_PLINK_1.99526231496888e.08 TRUE 324 Other CNS infection and poliomyelitis Both 4 53 6 neurological darkblue 53, 4 10, 0 18, 2 8, 0 13, 2 -0.337 0.795 0.672 0.173 0.714 0.118 3.94 0.374 1.31 0.776 0.11 1.45 0.104 57.4 -0.326 2.31 0.888 0.052 0.722 0.000835 55900000 PRS_PLINK_1.99526231496888e.08 TRUE 325 Phlebitis and thrombophlebitis of intracranial venous sinuses Both 1 15 6 neurological darkblue 15, 1 1, 0 4, 1 3, 0 4, 0 -1.03 1.88 0.584 0.234 0.357 0.324 6.63 0.0912 1210 1 0 1.1 0.859 1.53 PRS_PLINK_1.99526231496888e.08 TRUE 327 Sleep disorders Both 580 684 6 neurological darkblue 684, 580 102, 76 227, 198 115, 77 171, 164 0.0465 0.0584 0.426 0.37 1.05 0.935 1.17 0.0637 0.192 0.739 0.131 1.07 0.735 1.55 -0.132 0.234 0.572 0.242 0.876 0.556 1.38 0.209 0.201 0.298 0.526 1.23 0.836 1.82 PRS_PLINK_1.99526231496888e.08 FALSE 327.1 Hypersomnia Both 143 442 6 neurological darkblue 442, 143 66, 19 149, 53 70, 15 110, 43 0.124 0.09 0.167 0.776 1.13 0.951 1.35 0.161 0.322 0.616 0.21 1.17 0.638 2.22 -0.335 0.413 0.417 0.38 0.715 0.315 1.59 0.454 0.343 0.186 0.73 1.57 0.823 3.11 PRS_PLINK_1.99526231496888e.08 FALSE 327.3 Sleep apnea Both 375 680 6 neurological darkblue 680, 375 103, 51 225, 130 115, 45 169, 107 0.06 0.0678 0.376 0.425 1.06 0.928 1.21 0.0446 0.227 0.844 0.074 1.05 0.675 1.63 -0.164 0.28 0.558 0.253 0.848 0.491 1.46 0.24 0.237 0.311 0.508 1.27 0.805 2.02 PRS_PLINK_1.99526231496888e.08 FALSE 327.31 Central/nonobstroctive sleep apnea Both 15 53 6 neurological darkblue 53, 15 7, 3 16, 4 10, 3 13, 4 -0.0799 0.26 0.758 0.12 0.923 0.503 1.4 -0.19 1.1 0.862 0.064 0.827 0.104 7.07 -0.0476 1.63 0.977 0.01 0.953 0.0167 70.1 -1.29 1.8 0.475 0.323 0.276 4.12e-06 6.24 PRS_PLINK_1.99526231496888e.08 TRUE 327.32 Obstructive sleep apnea Both 331 660 6 neurological darkblue 660, 331 98, 48 221, 114 109, 40 164, 94 0.072 0.0699 0.303 0.519 1.07 0.936 1.23 -0.0391 0.235 0.868 0.062 0.962 0.611 1.52 -0.231 0.29 0.427 0.37 0.794 0.45 1.39 0.172 0.245 0.481 0.318 1.19 0.742 1.92 PRS_PLINK_1.99526231496888e.08 FALSE 327.4 Insomnia Both 311 680 6 neurological darkblue 680, 311 102, 36 227, 106 113, 49 169, 87 0.0879 0.067 0.19 0.722 1.09 0.958 1.24 0.215 0.239 0.367 0.435 1.24 0.784 1.99 0.194 0.279 0.485 0.314 1.21 0.709 2.09 0.346 0.25 0.166 0.779 1.41 0.874 2.31 PRS_PLINK_1.99526231496888e.08 FALSE 327.41 Organic or persistent insomnia Both 79 248 6 neurological darkblue 248, 79 33, 9 65, 17 59, 15 62, 27 0.168 0.139 0.228 0.642 1.18 0.918 1.58 -0.128 0.518 0.804 0.095 0.88 0.323 2.47 -0.0577 0.49 0.906 0.043 0.944 0.371 2.49 0.325 0.501 0.516 0.287 1.38 0.535 3.76 PRS_PLINK_1.99526231496888e.08 FALSE 327.5 Parasomnia Both 35 96 6 neurological darkblue 96, 35 12, 7 26, 5 22, 14 24, 5 0.059 0.222 0.791 0.102 1.06 0.652 1.56 -2.41 1.18 0.0408 1.389 0.0899 0.000437 0.745 0.135 0.714 0.85 0.071 1.15 0.306 4.7 -0.837 0.814 0.304 0.517 0.433 0.0791 1.96 PRS_PLINK_1.99526231496888e.08 TRUE 327.6 Circadian rhythm sleep disorder Both 19 80 6 neurological darkblue 80, 19 10, 1 20, 5 20, 1 20, 10 0.284 0.326 0.385 0.415 1.33 0.788 3.14 1.03 1.45 0.479 0.32 2.8 0.199 85.5 -0.626 1.35 0.643 0.192 0.534 0.00505 18.5 0.37 1.26 0.77 0.114 1.45 0.137 25.2 PRS_PLINK_1.99526231496888e.08 TRUE 327.7 Sleep related movement disorders Both 90 363 6 neurological darkblue 363, 90 56, 11 129, 30 49, 11 91, 27 0.029 0.112 0.796 0.099 1.03 0.805 1.25 0.0464 0.392 0.906 0.043 1.05 0.496 2.33 0.0682 0.486 0.888 0.051 1.07 0.407 2.77 0.329 0.398 0.408 0.389 1.39 0.651 3.11 PRS_PLINK_1.99526231496888e.08 FALSE 327.71 Restless legs syndrome Both 73 328 6 neurological darkblue 328, 73 50, 10 83, 18 82, 15 81, 23 0.062 0.14 0.658 0.182 1.06 0.796 1.38 -0.106 0.436 0.807 0.093 0.899 0.387 2.16 -0.209 0.458 0.648 0.188 0.811 0.332 2.02 0.248 0.422 0.557 0.254 1.28 0.573 3 PRS_PLINK_1.99526231496888e.08 FALSE 327.72 Sleep related leg cramps Both 2 13 6 neurological darkblue 13, 2 2, 0 3, 2 3, 0 3, 0 -0.124 1.16 0.915 0.039 0.883 0.108 6.65 0.0219 5410 1 0 1.02 0.543 2.58 PRS_PLINK_1.99526231496888e.08 TRUE 331 Other cerebral degenerations Both 19 110 6 neurological darkblue 110, 19 17, 1 38, 10 15, 4 28, 3 0.143 0.185 0.441 0.355 1.15 0.756 1.6 0.934 0.942 0.322 0.492 2.54 0.495 24.1 1.15 1.13 0.311 0.507 3.14 0.154 110 0.796 1.01 0.431 0.366 2.22 0.336 35.7 PRS_PLINK_1.99526231496888e.08 TRUE 331.1 Hydrocephalus Both 4 47 6 neurological darkblue 47, 4 10, 0 14, 1 8, 1 12, 2 1.35 0.899 0.133 0.877 3.87 0.484 217 -0.123 1.41 0.931 0.031 0.884 0.00016 1610 0.815 1.37 0.553 0.257 2.26 0.205 4440 1.32 1.46 0.366 0.436 3.74 0.258 816 PRS_PLINK_1.99526231496888e.08 TRUE 331.9 Cerebral degeneration, unspecified Both 15 47 6 neurological darkblue 47, 15 5, 2 16, 8 8, 4 11, 0 0.0108 0.269 0.968 0.014 1.01 0.49 1.55 0.145 1.05 0.89 0.05 1.16 0.19 8.67 -0.302 1.5 0.84 0.076 0.739 0.0305 16.9 -0.782 1.72 0.649 0.188 0.457 0.00364 81.7 PRS_PLINK_1.99526231496888e.08 TRUE 332 Parkinson's disease Both 4 47 6 neurological darkblue 47, 4 8, 0 15, 1 8, 2 12, 1 1.32 0.872 0.131 0.884 3.74 0.671 269 -0.178 1.82 0.922 0.035 0.837 0.00514 82.6 1.18 1.56 0.451 0.346 3.24 0.253 17900 -0.13 2.02 0.949 0.023 0.878 0.00162 996 PRS_PLINK_1.99526231496888e.08 TRUE 333 Extrapyramidal disease and abnormal movement disorders Both 126 642 6 neurological darkblue 642, 126 95, 16 206, 41 112, 18 159, 42 0.156 0.0913 0.0875 1.058 1.17 0.974 1.39 0.0564 0.322 0.861 0.065 1.06 0.568 2.04 -0.03 0.379 0.937 0.028 0.97 0.46 2.06 0.345 0.323 0.286 0.544 1.41 0.758 2.72 PRS_PLINK_1.99526231496888e.08 FALSE 333.1 Essential tremor Both 17 108 6 neurological darkblue 108, 17 15, 2 26, 3 27, 6 27, 6 0.355 0.374 0.343 0.465 1.43 0.687 3.15 -0.0971 0.965 0.92 0.036 0.907 0.0999 7.11 0.211 0.797 0.791 0.102 1.23 0.275 6.79 0.178 0.893 0.842 0.075 1.19 0.211 8.56 PRS_PLINK_1.99526231496888e.08 TRUE 333.2 Myoclonus Both 6 40 6 neurological darkblue 40, 6 2, 0 10, 2 10, 1 10, 3 0.851 0.693 0.219 0.659 2.34 0.659 13.2 0.35 3.15 0.911 0.04 1.42 0.0161 76700000 0.356 2.93 0.903 0.044 1.43 0.00276 19800 0.751 2.74 0.784 0.106 2.12 0.0186 454 PRS_PLINK_1.99526231496888e.08 TRUE 333.4 Torsion dystonia Both 17 83 6 neurological darkblue 83, 17 17, 3 22, 4 19, 1 21, 7 0.0822 0.303 0.786 0.104 1.09 0.591 1.93 0.27 0.88 0.759 0.12 1.31 0.253 8.55 -1.59 1.2 0.186 0.731 0.204 0.000759 2.01 0.328 0.778 0.673 0.172 1.39 0.342 6.41 PRS_PLINK_1.99526231496888e.08 TRUE 333.8 Other degenerative diseases of the basal ganglia Both 1 14 6 neurological darkblue 14, 1 4, 0 1, 0 3, 0 4, 1 0.137 1.82 0.94 0.027 1.15 0.00383 683 -0.24 2920 1 0 0.787 0.161 277 PRS_PLINK_1.99526231496888e.08 TRUE 334 Degenerative disease of the spinal cord Both 33 174 6 neurological darkblue 174, 33 29, 4 43, 6 42, 8 43, 11 0.0595 0.234 0.799 0.097 1.06 0.665 1.67 0.282 0.73 0.699 0.155 1.33 0.31 6.5 0.236 0.622 0.704 0.152 1.27 0.38 4.72 0.978 0.715 0.172 0.766 2.66 0.693 13.7 PRS_PLINK_1.99526231496888e.08 TRUE 334.1 Spinocerebellar disease Both 0 17 6 neurological darkblue 17, 0 3 4 4 4 PRS_PLINK_1.99526231496888e.08 TRUE 334.2 Anterior horn cell disease Both 1 16 6 neurological darkblue 16, 1 2, 0 4, 0 4, 0 4, 0 -0.181 1.23 0.884 0.054 0.835 0.00973 22.1 PRS_PLINK_1.99526231496888e.08 TRUE 334.21 Amyotrophic Lateral Sclerosis Both 1 11 6 neurological darkblue 11, 1 2, 0 3, 0 2, 0 3, 0 0.0875 2.18 0.968 0.014 1.09 0.0184 66.8 PRS_PLINK_1.99526231496888e.08 TRUE 335 Multiple sclerosis Both 20 120 6 neurological darkblue 120, 20 16, 3 31, 7 29, 3 30, 5 -0.0719 0.331 0.828 0.082 0.931 0.483 1.81 -0.0936 0.778 0.904 0.044 0.911 0.219 4.4 -0.311 0.962 0.746 0.127 0.732 0.0947 6.99 -0.172 0.796 0.829 0.081 0.842 0.186 4.09 PRS_PLINK_1.99526231496888e.08 TRUE 337 Disorders of the autonomic nervous system Both 37 191 6 neurological darkblue 191, 37 30, 5 47, 7 47, 9 48, 11 -0.0406 0.206 0.844 0.074 0.96 0.576 1.34 -0.406 0.631 0.52 0.284 0.666 0.181 2.38 0.372 0.612 0.543 0.265 1.45 0.455 5.11 0.199 0.603 0.741 0.13 1.22 0.38 4.22 PRS_PLINK_1.99526231496888e.08 TRUE 337.1 Peripheral autonomic neuropathy Both 20 82 6 neurological darkblue 82, 20 15, 4 24, 6 15, 2 21, 6 0.000243 0.224 0.999 0 1 0.462 1.38 -0.376 0.782 0.631 0.2 0.687 0.139 3.08 -0.344 1.02 0.737 0.132 0.709 0.0539 10.1 -0.182 0.943 0.847 0.072 0.834 0.123 5.52 PRS_PLINK_1.99526231496888e.08 TRUE 338 Pain Both 690 579 6 neurological darkblue 579, 690 93, 93 192, 228 97, 96 144, 192 0.0703 0.0583 0.228 0.642 1.07 0.96 1.2 0.0532 0.186 0.775 0.111 1.05 0.735 1.51 -0.00426 0.217 0.984 0.007 0.996 0.654 1.52 0.222 0.189 0.239 0.622 1.25 0.866 1.8 PRS_PLINK_1.99526231496888e.08 FALSE 338.1 Acute pain Both 489 577 6 neurological darkblue 577, 489 93, 63 191, 166 96, 71 144, 132 0.0501 0.0738 0.497 0.304 1.05 0.911 1.21 0.116 0.206 0.571 0.243 1.12 0.754 1.68 0.0969 0.238 0.684 0.165 1.1 0.694 1.75 0.208 0.21 0.321 0.493 1.23 0.821 1.85 PRS_PLINK_1.99526231496888e.08 FALSE 338.2 Chronic pain Both 481 576 6 neurological darkblue 576, 481 93, 68 191, 159 95, 61 144, 139 0.0818 0.0624 0.19 0.722 1.09 0.963 1.23 0.00663 0.204 0.974 0.011 1.01 0.678 1.5 -0.0915 0.245 0.709 0.149 0.913 0.567 1.47 0.211 0.207 0.307 0.513 1.23 0.828 1.85 PRS_PLINK_1.99526231496888e.08 FALSE 339 Other headache syndromes Both 534 633 6 neurological darkblue 633, 534 102, 58 155, 126 157, 139 158, 150 0.0867 0.0613 0.157 0.803 1.09 0.97 1.23 0.305 0.215 0.157 0.805 1.36 0.895 2.07 0.43 0.206 0.037 1.431 1.54 1.03 2.3 0.504 0.209 0.016 1.795 1.65 1.11 2.49 PRS_PLINK_1.99526231496888e.08 FALSE 340 Migraine Both 414 606 6 neurological darkblue 606, 414 98, 41 147, 85 151, 109 150, 129 0.145 0.0648 0.0256 1.592 1.16 1.02 1.32 0.257 0.246 0.298 0.526 1.29 0.803 2.1 0.561 0.231 0.0154 1.812 1.75 1.12 2.76 0.745 0.232 0.00129 2.888 2.11 1.35 3.33 PRS_PLINK_1.99526231496888e.08 FALSE 340.1 Migrain with aura Both 233 546 6 neurological darkblue 546, 233 85, 24 135, 52 134, 57 136, 75 0.207 0.073 0.00462 2.336 1.23 1.07 1.43 0.375 0.3 0.211 0.676 1.46 0.818 2.65 0.438 0.283 0.122 0.913 1.55 0.902 2.72 0.716 0.282 0.011 1.958 2.05 1.2 3.59 PRS_PLINK_1.99526231496888e.08 FALSE 341 Other demyelinating diseases of central nervous system Both 7 39 6 neurological darkblue 39, 7 6, 0 10, 2 9, 1 10, 2 0.117 0.547 0.831 0.08 1.12 0.402 3.47 0.893 1.64 0.585 0.233 2.44 0.000879 285 0.96 2.17 0.658 0.182 2.61 2.18 2.89 0.855 1.81 0.636 0.196 2.35 0.0793 573 PRS_PLINK_1.99526231496888e.08 TRUE 342 Hemiplegia Both 16 99 6 neurological darkblue 99, 16 15, 2 32, 6 18, 2 24, 5 0.158 0.4 0.693 0.16 1.17 0.526 2.68 -0.412 0.885 0.641 0.193 0.662 0.107 4.27 -0.417 1.03 0.686 0.164 0.659 0.0357 4.66 0.0467 0.854 0.956 0.019 1.05 0.204 6.27 PRS_PLINK_1.99526231496888e.08 TRUE 343 Infantile cerebral palsy Both 2 22 6 neurological darkblue 22, 2 5, 0 8, 0 2, 1 6, 1 1.65 1.31 0.206 0.686 5.22 0.479 949 0.028 731 1 0 1.03 0.599 1.3 -0.371 2.08 0.859 0.066 0.69 0.00024 107 PRS_PLINK_1.99526231496888e.08 TRUE 344 Other paralytic syndromes Both 23 121 6 neurological darkblue 121, 23 20, 1 40, 9 20, 1 30, 9 0.0571 0.328 0.862 0.065 1.06 0.56 2.05 2.93 1.6 0.067 1.174 18.8 1.24 3830 0.906 1.24 0.463 0.334 2.47 0.153 440 1.42 0.956 0.138 0.859 4.12 0.769 44.9 PRS_PLINK_1.99526231496888e.08 TRUE 345 Epilepsy, recurrent seizures, convulsions Both 91 685 6 neurological darkblue 685, 91 98, 11 229, 29 112, 17 170, 27 0.0962 0.0882 0.275 0.56 1.1 0.911 1.29 -0.016 0.371 0.966 0.015 0.984 0.48 2.13 0.251 0.397 0.528 0.277 1.28 0.584 2.92 0.363 0.369 0.325 0.489 1.44 0.704 3.11 PRS_PLINK_1.99526231496888e.08 FALSE 345.1 Epilepsy Both 21 184 6 neurological darkblue 184, 21 23, 0 61, 7 31, 4 46, 10 0.941 0.328 0.00409 2.388 2.56 1.4 5.6 1.99 1.39 0.152 0.819 7.32 0.687 2440 1.67 1.18 0.158 0.802 5.33 0.564 481 2.36 1.33 0.0769 1.114 10.5 1.16 2980 PRS_PLINK_1.99526231496888e.08 TRUE 345.11 Generalized convulsive epilepsy Both 8 67 6 neurological darkblue 67, 8 8, 0 17, 3 16, 4 17, 1 0.757 0.551 0.17 0.77 2.13 0.746 10.3 2.95 2.76 0.285 0.546 19.1 0.159 3.4e+11 0.833 1.59 0.601 0.221 2.3 0.128 316 -0.132 1.73 0.939 0.027 0.877 0.00426 227 PRS_PLINK_1.99526231496888e.08 TRUE 345.12 Partial epilepsy Both 16 130 6 neurological darkblue 130, 16 16, 0 39, 2 25, 5 33, 9 1.19 0.419 0.00457 2.34 3.28 1.46 8.84 1.08 1.41 0.447 0.35 2.93 0.116 37900 2.91 1.81 0.109 0.964 18.3 0.6 43200 1.56 1.19 0.191 0.72 4.76 0.547 382 PRS_PLINK_1.99526231496888e.08 TRUE 345.3 Convulsions Both 85 633 6 neurological darkblue 633, 85 91, 12 211, 27 106, 16 157, 24 0.0937 0.0941 0.319 0.496 1.1 0.893 1.3 -0.151 0.367 0.682 0.166 0.86 0.421 1.84 0.0906 0.399 0.82 0.086 1.09 0.495 2.47 0.168 0.369 0.65 0.187 1.18 0.575 2.54 PRS_PLINK_1.99526231496888e.08 FALSE 346 Abnormal findings on study of brain and/or nervous system Both 6 31 6 neurological darkblue 31, 6 3, 1 8, 2 7, 0 8, 3 0.331 0.649 0.609 0.215 1.39 0.434 5.32 -0.424 1.79 0.813 0.09 0.654 0.00114 41.5 -1.32 6.87 0.848 0.072 0.267 3.78e-05 411 1.16 1.81 0.521 0.283 3.19 0.201 10100 PRS_PLINK_1.99526231496888e.08 TRUE 346.1 Nonspecific abnormal findings on radiological and other examination of skull and head Both 60 286 6 neurological darkblue 286, 60 40, 10 88, 22 55, 10 71, 13 -0.119 0.161 0.457 0.34 0.887 0.616 1.18 -0.174 0.448 0.699 0.156 0.841 0.355 2.06 -0.435 0.503 0.388 0.411 0.647 0.237 1.73 -0.431 0.47 0.359 0.445 0.65 0.257 1.65 PRS_PLINK_1.99526231496888e.08 FALSE 346.2 Nonspecific abnormal results of function study of brain and central nervous system Both 4 22 6 neurological darkblue 22, 4 3, 1 5, 1 5, 0 6, 2 0.513 0.833 0.538 0.269 1.67 0.396 8.48 -0.358 4.85 0.941 0.026 0.699 0.631 0.763 -0.593 74.2 0.994 0.003 0.553 4.23e-05 4250 1.49 1.9 0.434 0.363 4.42 0.326 2280 PRS_PLINK_1.99526231496888e.08 TRUE 346.3 Nonspecific abnormal findings in cerebrospinal fluid Both 5 21 6 neurological darkblue 21, 5 5, 0 5, 3 5, 1 5, 1 1.11 1.18 0.346 0.46 3.03 0.0326 69.3 -0.23 2.21 0.917 0.038 0.794 0.00997 43.8 1.22 2.41 0.614 0.212 3.38 0.117 1300 1.62 3.14 0.606 0.217 5.04 0.0177 3520 PRS_PLINK_1.99526231496888e.08 TRUE 347 Cataplexy and narcolepsy Both 5 39 6 neurological darkblue 39, 5 6, 0 11, 1 8, 1 10, 3 0.0574 0.273 0.833 0.079 1.06 0.534 1.8 0.116 1.68 0.945 0.025 1.12 0.0193 62 0.549 700 0.999 0 1.73 0.422 11.9 0.711 1.71 0.678 0.169 2.04 0.0096 235 PRS_PLINK_1.99526231496888e.08 TRUE 348 Other conditions of brain Both 47 418 6 neurological darkblue 418, 47 69, 5 141, 18 63, 3 105, 14 -0.054 0.156 0.729 0.137 0.947 0.641 1.23 0.443 0.502 0.378 0.422 1.56 0.592 4.74 -0.45 0.654 0.491 0.309 0.637 0.142 2.52 0.63 0.515 0.222 0.655 1.88 0.689 5.83 PRS_PLINK_1.99526231496888e.08 TRUE 348.2 Cerebral edema and compression of brain Both 22 225 6 neurological darkblue 225, 22 24, 4 82, 6 30, 1 56, 8 0.0667 0.156 0.668 0.175 1.07 0.687 1.37 -0.651 0.706 0.356 0.448 0.521 0.128 2.27 -1.03 0.845 0.221 0.655 0.356 0.0395 1.88 0.213 0.632 0.736 0.133 1.24 0.371 4.62 PRS_PLINK_1.99526231496888e.08 TRUE 348.4 Cerebral cysts Both 13 61 6 neurological darkblue 61, 13 8, 1 16, 5 15, 1 14, 4 0.0346 0.183 0.85 0.071 1.04 0.584 1.35 0.538 1.26 0.671 0.173 1.71 0.17 36.8 -0.187 1.44 0.897 0.047 0.83 0.0241 22.7 1.35 1.62 0.402 0.396 3.88 0.186 2530 PRS_PLINK_1.99526231496888e.08 TRUE 348.7 Coma Both 10 49 6 neurological darkblue 49, 10 7, 1 12, 1 12, 3 12, 2 -0.547 0.504 0.278 0.557 0.578 0.205 1.48 -0.809 1.89 0.668 0.175 0.445 7.4e-05 17.9 -0.522 2.04 0.798 0.098 0.594 0.00788 33.5 0.745 1.65 0.651 0.187 2.11 0.118 96.3 PRS_PLINK_1.99526231496888e.08 TRUE 348.8 Encephalopathy, not elsewhere classified Both 16 192 6 neurological darkblue 192, 16 29, 2 66, 6 30, 1 48, 4 -0.0665 0.312 0.831 0.08 0.936 0.489 1.81 0.156 0.719 0.828 0.082 1.17 0.29 6.34 -1.2 1.02 0.241 0.617 0.301 0.00983 2.39 0.368 0.779 0.636 0.196 1.45 0.302 9.09 PRS_PLINK_1.99526231496888e.08 TRUE 348.9 Other conditions of brain, NOS Both 74 512 6 neurological darkblue 512, 74 68, 13 167, 29 89, 11 128, 14 -0.0366 0.142 0.797 0.099 0.964 0.704 1.25 -0.157 0.38 0.679 0.168 0.855 0.413 1.84 -0.0998 0.462 0.829 0.081 0.905 0.365 2.26 -0.483 0.433 0.265 0.576 0.617 0.262 1.47 PRS_PLINK_1.99526231496888e.08 FALSE 349 Other and unspecified disorders of the nervous system Both 37 231 6 neurological darkblue 231, 37 42, 4 73, 12 40, 3 57, 10 -0.157 0.204 0.441 0.356 0.854 0.515 1.19 0.588 0.59 0.32 0.495 1.8 0.595 6.54 0.435 0.759 0.566 0.247 1.55 0.313 7.91 0.54 0.602 0.37 0.432 1.72 0.533 6.41 PRS_PLINK_1.99526231496888e.08 TRUE 350 Abnormal movement Both 255 981 6 neurological darkblue 981, 255 136, 21 337, 99 155, 33 242, 81 0.112 0.0675 0.097 1.013 1.12 0.977 1.27 0.583 0.267 0.029 1.538 1.79 1.08 3.09 0.309 0.325 0.343 0.465 1.36 0.726 2.61 0.644 0.272 0.018 1.745 1.9 1.13 3.32 PRS_PLINK_1.99526231496888e.08 FALSE 350.1 Abnormal involuntary movements Both 149 697 6 neurological darkblue 697, 149 102, 16 238, 55 109, 15 171, 53 0.176 0.0899 0.0501 1.3 1.19 0.999 1.42 0.315 0.306 0.304 0.517 1.37 0.764 2.56 -0.153 0.387 0.692 0.16 0.858 0.395 1.85 0.507 0.313 0.105 0.977 1.66 0.911 3.15 PRS_PLINK_1.99526231496888e.08 FALSE 350.2 Abnormality of gait Both 128 619 6 neurological darkblue 619, 128 87, 12 212, 49 96, 21 155, 38 0.138 0.105 0.189 0.723 1.15 0.931 1.4 0.49 0.35 0.162 0.79 1.63 0.843 3.36 0.392 0.412 0.342 0.466 1.48 0.666 3.4 0.493 0.362 0.174 0.761 1.64 0.82 3.45 PRS_PLINK_1.99526231496888e.08 FALSE 350.3 Lack of coordination Both 50 241 6 neurological darkblue 241, 50 38, 8 69, 16 50, 7 60, 15 0.206 0.167 0.218 0.662 1.23 0.89 1.71 0.138 0.482 0.774 0.111 1.15 0.459 3.05 -0.821 0.601 0.172 0.764 0.44 0.121 1.41 0.127 0.485 0.794 0.1 1.14 0.446 3.02 PRS_PLINK_1.99526231496888e.08 TRUE 350.5 Abnormal reflex Both 7 37 6 neurological darkblue 37, 7 4, 1 9, 2 9, 1 9, 1 -1.06 0.601 0.0787 1.104 0.347 0.0802 1.02 -0.0269 1.76 0.988 0.005 0.973 0.0173 114 -0.741 2.06 0.719 0.143 0.477 0.000111 18.5 -0.958 2.52 0.704 0.152 0.384 0.00154 32.6 PRS_PLINK_1.99526231496888e.08 TRUE 350.6 Disturbances of sensation of smell and taste Both 14 110 6 neurological darkblue 110, 14 18, 2 37, 5 17, 2 28, 3 0.228 0.381 0.55 0.26 1.26 0.584 2.87 -0.264 0.849 0.756 0.121 0.768 0.143 4.66 0.255 1.16 0.826 0.083 1.29 0.101 17.5 0.821 0.986 0.405 0.392 2.27 0.328 27.1 PRS_PLINK_1.99526231496888e.08 TRUE 351 Other peripheral nerve disorders Both 344 786 6 neurological darkblue 786, 344 120, 37 260, 120 132, 55 195, 97 0.155 0.0687 0.0245 1.612 1.17 1.02 1.34 0.279 0.228 0.221 0.656 1.32 0.853 2.08 0.311 0.264 0.239 0.622 1.36 0.82 2.29 0.436 0.235 0.0636 1.197 1.55 0.985 2.46 PRS_PLINK_1.99526231496888e.08 FALSE 352 Disorders of other cranial nerves Both 60 380 6 neurological darkblue 380, 60 62, 9 123, 21 66, 7 93, 15 0.122 0.143 0.393 0.406 1.13 0.846 1.48 0.141 0.43 0.743 0.129 1.15 0.504 2.8 -0.228 0.527 0.665 0.177 0.796 0.269 2.31 0.135 0.453 0.766 0.116 1.14 0.473 2.9 PRS_PLINK_1.99526231496888e.08 FALSE 352.1 Trigeminal nerve disorders [CN5] Both 29 141 6 neurological darkblue 141, 29 21, 2 51, 13 19, 0 35, 9 0.148 0.173 0.394 0.404 1.16 0.856 1.66 0.711 0.759 0.349 0.457 2.04 0.509 11.3 -1.25 1.2 0.298 0.526 0.286 0.00253 3.18 0.716 0.778 0.358 0.447 2.05 0.492 11.2 PRS_PLINK_1.99526231496888e.08 TRUE 352.2 Facial nerve disorders [CN7] Both 23 164 6 neurological darkblue 164, 23 25, 4 42, 3 40, 7 41, 6 -0.0327 0.289 0.91 0.041 0.968 0.546 1.74 -0.0856 0.774 0.912 0.04 0.918 0.185 4.83 0.302 0.732 0.679 0.168 1.35 0.338 6.76 0.225 0.715 0.753 0.123 1.25 0.316 5.67 PRS_PLINK_1.99526231496888e.08 TRUE 353 Nerve root and plexus disorders Both 177 739 6 neurological darkblue 739, 177 110, 13 245, 60 125, 30 184, 48 0.114 0.0916 0.214 0.67 1.12 0.932 1.33 0.638 0.33 0.0531 1.275 1.89 1.01 3.75 0.717 0.373 0.0542 1.266 2.05 1 4.38 0.713 0.352 0.0428 1.368 2.04 1.04 4.22 PRS_PLINK_1.99526231496888e.08 FALSE 353.1 Nerve plexus lesions Both 16 96 6 neurological darkblue 96, 16 16, 2 24, 6 26, 2 22, 3 -0.696 0.407 0.0873 1.059 0.499 0.209 1.09 0.374 1.05 0.721 0.142 1.45 0.14 20.2 -0.226 1.17 0.847 0.072 0.797 0.0218 10.4 0.306 1.02 0.763 0.117 1.36 0.188 11.6 PRS_PLINK_1.99526231496888e.08 TRUE 353.2 Nerve root lesions Both 8 27 6 neurological darkblue 27, 8 3, 0 7, 4 6, 2 7, 2 0.826 0.806 0.306 0.515 2.28 0.529 50 0.511 2.76 0.853 0.069 1.67 0.0301 1310 0.0325 2.88 0.991 0.004 1.03 0.899 1.1 0.24 2.39 0.92 0.036 1.27 0.895 1.87 PRS_PLINK_1.99526231496888e.08 TRUE 355 Complex regional/central pain syndrome Both 28 155 6 neurological darkblue 155, 28 16, 2 40, 6 37, 11 39, 6 0.151 0.272 0.578 0.238 1.16 0.683 2.02 -0.624 0.887 0.482 0.317 0.536 0.0852 4.1 0.702 0.809 0.385 0.414 2.02 0.479 12.3 -0.652 0.857 0.447 0.35 0.521 0.0974 3.34 PRS_PLINK_1.99526231496888e.08 TRUE 355.1 Chronic pain syndrome Both 53 210 6 neurological darkblue 210, 53 25, 6 70, 20 34, 7 53, 17 0.243 0.172 0.158 0.802 1.27 0.945 1.87 -0.106 0.545 0.846 0.073 0.9 0.32 2.75 0.34 0.79 0.667 0.176 1.4 0.3 7.9 0.0373 0.565 0.947 0.024 1.04 0.36 3.25 PRS_PLINK_1.99526231496888e.08 FALSE 356 Hereditary and idiopathic peripheral neuropathy Both 90 401 6 neurological darkblue 401, 90 58, 9 100, 23 104, 30 96, 22 0.185 0.124 0.137 0.863 1.2 0.946 1.53 0.213 0.446 0.633 0.199 1.24 0.53 3.06 0.598 0.422 0.156 0.807 1.82 0.823 4.34 0.278 0.423 0.512 0.291 1.32 0.588 3.15 PRS_PLINK_1.99526231496888e.08 FALSE 357 Inflammatory and toxic neuropathy Both 116 589 6 neurological darkblue 589, 116 86, 9 148, 29 147, 32 146, 33 0.227 0.0931 0.0149 1.828 1.25 1.06 1.52 0.49 0.405 0.226 0.645 1.63 0.754 3.82 0.646 0.399 0.106 0.976 1.91 0.898 4.4 0.767 0.392 0.0505 1.297 2.15 1.02 4.92 PRS_PLINK_1.99526231496888e.08 FALSE 358 Myoneural disorders Both 51 265 6 neurological darkblue 265, 51 35, 1 65, 15 66, 13 66, 18 0.214 0.168 0.202 0.694 1.24 0.895 1.73 1.56 0.817 0.057 1.244 4.74 1.08 44.2 1.21 0.806 0.132 0.878 3.36 0.782 30.4 1.72 0.842 0.0408 1.389 5.6 1.3 52.8 PRS_PLINK_1.99526231496888e.08 FALSE 358.1 Myasthenia gravis Both 1 17 6 neurological darkblue 17, 1 5, 1 3, 0 5, 0 3, 0 0.572 1.21 0.637 0.196 1.77 0.183 363 12 113 0.915 0.039 162000 77800 342000 -0.534 2.42 0.826 0.083 0.586 0.0249 77.5 1.46 14 0.917 0.038 4.33 3.92 4.75 PRS_PLINK_1.99526231496888e.08 TRUE 359 Muscular dystrophies and other myopathies Both 59 308 6 neurological darkblue 308, 59 46, 4 111, 21 42, 13 77, 15 0.107 0.12 0.373 0.428 1.11 0.872 1.39 0.623 0.567 0.272 0.565 1.86 0.648 6.49 1.26 0.613 0.0392 1.407 3.54 1.1 13.9 0.925 0.629 0.142 0.849 2.52 0.75 10.1 PRS_PLINK_1.99526231496888e.08 FALSE 359.1 Muscular dystrophies Both 1 16 6 neurological darkblue 16, 1 4, 0 5, 1 3, 0 4, 0 0.184 1.71 0.914 0.039 1.2 0.0428 704 1.44 2.76 0.602 0.221 4.22 0.138 4.59 PRS_PLINK_1.99526231496888e.08 TRUE 359.2 Myopathy Both 58 300 6 neurological darkblue 300, 58 43, 4 105, 20 43, 13 75, 15 0.107 0.12 0.371 0.431 1.11 0.875 1.39 0.529 0.565 0.349 0.457 1.7 0.588 5.9 1.23 0.627 0.05 1.301 3.42 1.03 13.4 0.907 0.635 0.154 0.813 2.48 0.733 9.9 PRS_PLINK_1.99526231496888e.08 FALSE 360 Disorders of the globe Both 10 27 7 sense organs darkseagreen4 27, 10 6, 1 10, 2 3, 2 7, 4 0.00373 0.316 0.991 0.004 1 0.565 5.61 -0.581 1.66 0.726 0.139 0.559 0.00183 33.2 0.326 2.23 0.884 0.054 1.39 0.00873 2030 1.38 2.18 0.526 0.279 3.98 0.056 8100 PRS_PLINK_1.99526231496888e.08 TRUE 360.2 Progressive myopia Both 5 17 7 sense organs darkseagreen4 17, 5 4, 0 4, 1 4, 0 4, 4 1.9 1.36 0.161 0.792 6.71 0.722 5110 0.327 3040000 1 0 1.39 0.189 5.59 1.53 2.75 0.577 0.239 4.64 0.0784 630 PRS_PLINK_1.99526231496888e.08 TRUE 361 Retinal detachments and defects Both 30 119 7 sense organs darkseagreen4 119, 30 19, 6 39, 8 20, 3 30, 11 0.0777 0.274 0.777 0.11 1.08 0.637 1.86 -0.418 0.648 0.519 0.285 0.658 0.188 2.35 -1.16 0.923 0.211 0.676 0.315 0.0321 1.76 0.0964 0.675 0.886 0.052 1.1 0.317 4.03 PRS_PLINK_1.99526231496888e.08 TRUE 361.1 Retinal detachment with retinal defect Both 13 56 7 sense organs darkseagreen4 56, 13 6, 2 14, 4 14, 2 14, 4 -0.1 0.403 0.804 0.095 0.905 0.41 2.02 0.205 1.32 0.877 0.057 1.23 0.0132 30.4 -0.553 1.33 0.677 0.17 0.575 0.00716 117 0.495 1.35 0.714 0.146 1.64 0.149 30.1 PRS_PLINK_1.99526231496888e.08 TRUE 362 Other retinal disorders Both 131 364 7 sense organs darkseagreen4 364, 131 44, 15 91, 44 91, 27 91, 33 0.091 0.105 0.385 0.415 1.1 0.896 1.34 0.197 0.366 0.591 0.228 1.22 0.608 2.51 -0.321 0.391 0.412 0.385 0.725 0.341 1.56 -0.153 0.381 0.687 0.163 0.858 0.411 1.82 PRS_PLINK_1.99526231496888e.08 FALSE 362.2 Degeneration of macula and posterior pole of retina Both 75 201 7 sense organs darkseagreen4 201, 75 27, 10 52, 26 48, 13 50, 20 -0.116 0.188 0.537 0.27 0.89 0.617 1.28 0.251 0.47 0.593 0.227 1.29 0.529 3.27 -0.198 0.513 0.7 0.155 0.82 0.307 2.24 -0.197 0.478 0.681 0.167 0.821 0.331 2.09 PRS_PLINK_1.99526231496888e.08 FALSE 362.21 Macular degeneration, dry Both 17 22 7 sense organs darkseagreen4 22, 17 4, 0 5, 5 5, 7 6, 2 -0.341 0.671 0.611 0.214 0.711 0.178 2.47 -0.0483 2.95 0.987 0.006 0.953 0.000195 241 1.92 1.8 0.289 0.54 6.79 0.499 3820 -2.39 3.89 0.539 0.269 0.0917 5.09e-06 16.5 PRS_PLINK_1.99526231496888e.08 TRUE 362.22 Macular degeneration, wet Both 4 8 7 sense organs darkseagreen4 8, 4 1, 0 2, 1 2, 1 2, 2 2.67 4.04 0.509 0.294 14.5 0.048 16.2 1.28 23400 1 0 3.61 0.00528 4320 0.2 38500 1 0 1.22 0.226 72.7 0.0253 1980 1 0 1.03 0.736 1.48 PRS_PLINK_1.99526231496888e.08 TRUE 362.23 Cystoid macular degeneration of retina Both 13 46 7 sense organs darkseagreen4 46, 13 8, 2 11, 3 11, 2 12, 5 0.0257 0.475 0.957 0.019 1.03 0.413 2.66 -0.756 1.27 0.553 0.257 0.47 0.0103 4.56 -1.02 1.53 0.504 0.297 0.36 0.00879 6.16 -0.249 1.2 0.836 0.078 0.78 0.0755 6.69 PRS_PLINK_1.99526231496888e.08 TRUE 362.26 Macular puckering of retina Both 34 118 7 sense organs darkseagreen4 118, 34 19, 8 34, 10 24, 4 30, 9 -0.249 0.264 0.346 0.461 0.78 0.465 1.3 -0.449 0.623 0.472 0.326 0.639 0.191 2.12 -0.642 0.787 0.414 0.383 0.526 0.0305 0.609 -0.772 0.671 0.25 0.602 0.462 0.122 1.64 PRS_PLINK_1.99526231496888e.08 TRUE 362.27 Drusen (degenerative) of retina Both 19 56 7 sense organs darkseagreen4 56, 19 7, 1 15, 2 13, 10 14, 4 -0.00114 0.403 0.998 0.001 0.999 0.464 2.16 -0.0325 1.16 0.978 0.01 0.968 0.116 10.4 0.855 1.13 0.448 0.349 2.35 0.342 23.4 0.329 1.37 0.811 0.091 1.39 0.114 52.9 PRS_PLINK_1.99526231496888e.08 TRUE 362.29 Macular degeneration (senile) of retina NOS Both 66 181 7 sense organs darkseagreen4 181, 66 24, 9 51, 22 40, 10 44, 19 -0.0966 0.199 0.627 0.202 0.908 0.616 1.34 -0.0238 0.492 0.961 0.017 0.976 0.384 2.57 -0.399 0.551 0.47 0.328 0.671 0.231 1.95 -0.252 0.512 0.623 0.205 0.778 0.295 2.09 PRS_PLINK_1.99526231496888e.08 FALSE 362.3 Other nondiabetic retinopathy Both 32 128 7 sense organs darkseagreen4 128, 32 16, 9 34, 11 30, 5 32, 4 -0.4 0.266 0.132 0.88 0.67 0.396 1.11 -0.578 0.637 0.364 0.439 0.561 0.164 1.88 -1.92 0.832 0.0208 1.681 0.146 0.0221 0.672 -1.57 0.753 0.0368 1.434 0.208 0.0432 0.836 PRS_PLINK_1.99526231496888e.08 TRUE 362.31 Separation of retinal layers Both 13 60 7 sense organs darkseagreen4 60, 13 11, 5 17, 4 13, 1 15, 2 -0.849 0.501 0.09 1.046 0.428 0.139 1.1 -1.6 1.39 0.249 0.603 0.201 0.00622 2.6 -2.11 1.27 0.0961 1.017 0.121 0.00132 1.34 -1.56 1.26 0.217 0.663 0.211 0.00235 1.93 PRS_PLINK_1.99526231496888e.08 TRUE 362.4 Retinal vascular changes and abnomalities Both 26 79 7 sense organs darkseagreen4 79, 26 11, 2 22, 7 17, 8 20, 8 0.255 0.319 0.425 0.372 1.29 0.705 2.42 0.346 0.891 0.698 0.156 1.41 0.277 9.64 0.189 1.05 0.857 0.067 1.21 0.162 11.2 0.262 1.01 0.795 0.099 1.3 0.195 10.3 PRS_PLINK_1.99526231496888e.08 TRUE 362.6 Peripheral retinal degenerations Both 20 75 7 sense organs darkseagreen4 75, 20 11, 1 19, 7 18, 5 19, 6 0.201 0.398 0.614 0.212 1.22 0.574 2.72 1.53 1.33 0.249 0.603 4.64 0.369 218 0.74 1.22 0.543 0.265 2.1 0.154 33.9 0.715 1.04 0.493 0.307 2.04 0.293 25.3 PRS_PLINK_1.99526231496888e.08 TRUE 362.7 Hereditary retinal dystrophies Both 12 33 7 sense organs darkseagreen4 33, 12 4, 1 8, 5 8, 2 8, 1 -0.459 0.462 0.321 0.494 0.632 0.255 1.42 1.64 2.12 0.44 0.356 5.13 0.041 8 0.389 2.92 0.894 0.049 1.48 1.83e-05 249 0.754 3 0.802 0.096 2.12 0.0222 1790 PRS_PLINK_1.99526231496888e.08 TRUE 362.8 Retinal hemorrhage/ischemia Both 17 45 7 sense organs darkseagreen4 45, 17 7, 0 12, 1 10, 4 11, 9 0.349 0.272 0.199 0.701 1.42 0.99 4.13 0.0308 1.6 0.985 0.007 1.03 0.00988 91.6 0.772 1.59 0.627 0.203 2.16 0.0956 206 2.69 1.8 0.136 0.868 14.8 0.851 27700 PRS_PLINK_1.99526231496888e.08 TRUE 362.9 Retinal edema Both 11 62 7 sense organs darkseagreen4 62, 11 9, 0 15, 1 15, 3 16, 7 0.801 0.374 0.0321 1.493 2.23 1.21 7.36 -0.104 1.43 0.942 0.026 0.901 0.00343 48.8 2.62 1.84 0.156 0.808 13.7 0.627 5420 2.36 1.52 0.121 0.917 10.6 0.864 1520 PRS_PLINK_1.99526231496888e.08 TRUE 363 Chorioretinal inflammations, scars, and other disorders of choroid Both 25 87 7 sense organs darkseagreen4 87, 25 11, 2 32, 11 10, 2 22, 6 -0.111 0.278 0.691 0.161 0.895 0.456 1.42 0.787 0.943 0.403 0.394 2.2 0.413 22.2 -0.721 1.59 0.65 0.187 0.486 0.00674 9.4 -0.0413 1.22 0.973 0.012 0.96 0.115 1.38 PRS_PLINK_1.99526231496888e.08 TRUE 363.3 Chorioretinal scars Both 20 61 7 sense organs darkseagreen4 61, 20 7, 1 15, 4 15, 5 15, 6 -0.00467 0.269 0.986 0.006 0.995 0.486 1.53 -0.0374 1.36 0.978 0.01 0.963 0.0578 24.3 -0.333 1.2 0.781 0.107 0.717 0.0676 9.03 0.218 1.5 0.884 0.053 1.24 0.101 1.84 PRS_PLINK_1.99526231496888e.08 TRUE 364 Corneal opacity and other disorders of cornea Both 39 206 7 sense organs darkseagreen4 206, 39 34, 2 50, 14 51, 9 52, 11 0.0315 0.194 0.871 0.06 1.03 0.669 1.44 2.28 0.888 0.0102 1.991 9.78 2.01 82 1.27 0.749 0.0908 1.042 3.55 0.893 20.6 0.774 0.726 0.286 0.544 2.17 0.55 11.8 PRS_PLINK_1.99526231496888e.08 TRUE 364.1 Corneal opacity Both 25 74 7 sense organs darkseagreen4 74, 25 9, 2 20, 7 16, 4 19, 10 0.393 0.351 0.262 0.582 1.48 0.773 2.96 -0.254 1.21 0.833 0.079 0.775 0.0808 7.63 -0.203 1.23 0.869 0.061 0.816 0.0864 10.6 1.36 1.26 0.278 0.557 3.91 0.43 136 PRS_PLINK_1.99526231496888e.08 TRUE 364.2 Corneal edema Both 5 25 7 sense organs darkseagreen4 25, 5 5, 1 6, 2 6, 0 6, 2 -0.249 0.861 0.772 0.112 0.779 0.0768 8.31 0.744 2.61 0.776 0.11 2.1 0.0255 330000 -0.829 3.93 0.833 0.079 0.436 1.34e-07 529 0.666 1.77 0.706 0.151 1.95 0.0867 583 PRS_PLINK_1.99526231496888e.08 TRUE 364.4 Corneal degenerations Both 18 90 7 sense organs darkseagreen4 90, 18 14, 2 21, 4 22, 5 23, 4 -0.353 0.366 0.335 0.475 0.702 0.338 1.43 0.479 1.16 0.679 0.168 1.61 0.206 43.8 0.939 0.984 0.34 0.469 2.56 0.468 27.9 -0.812 1.05 0.438 0.359 0.444 0.0258 3.35 PRS_PLINK_1.99526231496888e.08 TRUE 364.41 Keratoconus Both 1 22 7 sense organs darkseagreen4 22, 1 4, 0 5, 0 5, 0 6, 1 0.459 1.03 0.655 0.184 1.58 0.189 314 0.522 4.54 0.909 0.042 1.69 1.63 1.74 PRS_PLINK_1.99526231496888e.08 TRUE 364.5 Corneal dystrophy Both 14 57 7 sense organs darkseagreen4 57, 14 10, 2 14, 6 14, 0 14, 6 0.159 0.194 0.411 0.386 1.17 0.703 1.61 0.784 0.947 0.408 0.389 2.19 0.412 15.2 -1.75 1.54 0.256 0.592 0.174 6.79e-05 2.64 0.669 1.05 0.525 0.28 1.95 0.194 18.4 PRS_PLINK_1.99526231496888e.08 TRUE 364.51 Fuchs' dystrophy Both 10 30 7 sense organs darkseagreen4 30, 10 4, 2 10, 4 4, 0 8, 4 0.252 0.582 0.665 0.177 1.29 0.412 3.87 0.906 1.77 0.609 0.216 2.47 0.0146 5610 -5.64 71 0.937 0.028 0.00354 0.00249 0.00502 0.0172 1.37 0.99 0.004 1.02 0.00252 13.8 PRS_PLINK_1.99526231496888e.08 TRUE 364.9 Cornea replaced by transplant Both 4 15 7 sense organs darkseagreen4 15, 4 2, 0 4, 0 3, 3 4, 1 0.986 1.34 0.462 0.335 2.68 0.202 12600 -0.0546 1080 1 0 0.947 0.141 8.34 0.0326 2500 1 0 1.03 0.339 3.62 PRS_PLINK_1.99526231496888e.08 TRUE 365 Glaucoma Both 93 375 7 sense organs darkseagreen4 375, 93 51, 8 126, 35 61, 16 94, 31 0.401 0.147 0.00659 2.181 1.49 1.14 2.04 0.485 0.435 0.266 0.576 1.62 0.717 4.03 0.493 0.486 0.31 0.508 1.64 0.651 4.36 0.589 0.434 0.175 0.758 1.8 0.798 4.44 PRS_PLINK_1.99526231496888e.08 FALSE 365.1 Open-angle glaucoma Both 20 80 7 sense organs darkseagreen4 80, 20 10, 1 22, 3 18, 8 20, 7 0.533 0.36 0.138 0.859 1.7 0.862 3.63 -0.364 1.37 0.791 0.102 0.695 0.00523 22.1 0.563 1.19 0.635 0.197 1.76 0.171 25.7 0.782 1.56 0.615 0.211 2.19 0.0846 178 PRS_PLINK_1.99526231496888e.08 TRUE 365.11 Primary open angle glaucoma Both 7 40 7 sense organs darkseagreen4 40, 7 8, 0 13, 1 7, 1 10, 5 1.72 0.841 0.0415 1.382 5.56 1.19 91.2 0.021 1.38 0.988 0.005 1.02 0.043 44.1 0.713 1.57 0.65 0.187 2.04 0.0563 75.1 2.25 1.78 0.207 0.685 9.52 0.649 3.1e+10 PRS_PLINK_1.99526231496888e.08 TRUE 365.2 Primary angle-closure glaucoma Both 10 51 7 sense organs darkseagreen4 51, 10 7, 0 18, 6 7, 1 13, 2 0.0145 0.517 0.978 0.01 1.01 0.354 2.97 -0.0281 1.51 0.985 0.007 0.972 0.0179 108 0.0994 2.15 0.963 0.016 1.1 0.00388 44.9 0.283 1.72 0.869 0.061 1.33 0.0284 372 PRS_PLINK_1.99526231496888e.08 TRUE 366 Cataract Both 274 515 7 sense organs darkseagreen4 515, 274 79, 39 169, 96 84, 45 129, 68 0.0177 0.0891 0.842 0.075 1.02 0.85 1.2 -0.101 0.285 0.725 0.14 0.904 0.519 1.58 -0.00896 0.322 0.978 0.01 0.991 0.528 1.86 -0.0918 0.288 0.75 0.125 0.912 0.52 1.6 PRS_PLINK_1.99526231496888e.08 FALSE 366.1 Nonsenile Cataract Both 9 25 7 sense organs darkseagreen4 25, 9 -0.623 0.616 0.312 0.506 0.536 0.155 1.59 PRS_PLINK_1.99526231496888e.08 TRUE 366.2 Senile cataract Both 209 382 7 sense organs darkseagreen4 382, 209 54, 28 127, 76 62, 36 96, 46 -0.0977 0.116 0.4 0.398 0.907 0.715 1.13 0.0209 0.33 0.95 0.022 1.02 0.539 1.95 0.0874 0.376 0.816 0.088 1.09 0.524 2.28 -0.244 0.348 0.484 0.316 0.784 0.398 1.54 PRS_PLINK_1.99526231496888e.08 FALSE 367 Disorders of refraction and accommodation; blindness and low vision Both 548 721 7 sense organs darkseagreen4 721, 548 104, 56 242, 204 117, 82 179, 151 0.0266 0.059 0.652 0.186 1.03 0.915 1.15 0.438 0.204 0.0317 1.5 1.55 1.05 2.31 0.247 0.236 0.296 0.529 1.28 0.812 2.03 0.391 0.207 0.0586 1.232 1.48 0.993 2.21 PRS_PLINK_1.99526231496888e.08 FALSE 367.1 Myopia Both 365 690 7 sense organs darkseagreen4 690, 365 101, 38 232, 132 113, 52 170, 102 0.0299 0.0629 0.634 0.198 1.03 0.91 1.16 0.407 0.233 0.0806 1.094 1.5 0.961 2.38 0.174 0.265 0.512 0.291 1.19 0.714 1.99 0.406 0.234 0.0821 1.086 1.5 0.96 2.38 PRS_PLINK_1.99526231496888e.08 FALSE 367.2 Astigmatism Both 277 629 7 sense organs darkseagreen4 629, 277 88, 27 213, 106 100, 44 157, 69 -0.0165 0.0764 0.829 0.082 0.984 0.842 1.13 0.386 0.263 0.142 0.849 1.47 0.891 2.48 0.392 0.3 0.191 0.718 1.48 0.833 2.67 0.244 0.269 0.364 0.439 1.28 0.763 2.17 PRS_PLINK_1.99526231496888e.08 FALSE 367.8 Hypermetropia Both 127 298 7 sense organs darkseagreen4 298, 127 39, 8 104, 52 45, 17 74, 38 0.0761 0.117 0.514 0.289 1.08 0.857 1.35 0.827 0.442 0.0611 1.214 2.29 1 5.69 0.73 0.552 0.186 0.731 2.08 0.739 6.33 0.73 0.455 0.109 0.963 2.07 0.891 5.22 PRS_PLINK_1.99526231496888e.08 FALSE 367.9 Blindness and low vision Both 48 201 7 sense organs darkseagreen4 201, 48 32, 9 73, 20 26, 4 50, 10 -0.115 0.183 0.532 0.274 0.892 0.602 1.24 -0.353 0.486 0.468 0.329 0.703 0.275 1.85 -0.702 0.656 0.285 0.545 0.496 0.131 1.64 -0.381 0.536 0.476 0.322 0.683 0.24 1.93 PRS_PLINK_1.99526231496888e.08 TRUE 368 Visual disturbances Both 296 950 7 sense organs darkseagreen4 950, 296 141, 27 320, 110 150, 43 237, 86 0.117 0.0644 0.0692 1.16 1.12 0.991 1.27 0.522 0.243 0.0314 1.504 1.69 1.06 2.75 0.406 0.287 0.157 0.804 1.5 0.861 2.65 0.617 0.25 0.0136 1.867 1.85 1.15 3.07 PRS_PLINK_1.99526231496888e.08 FALSE 368.1 Amblyopia Both 38 147 7 sense organs darkseagreen4 147, 38 25, 2 48, 8 24, 7 37, 18 0.678 0.274 0.0131 1.882 1.97 1.18 3.45 0.519 0.752 0.49 0.31 1.68 0.398 9.61 0.903 0.816 0.268 0.571 2.47 0.531 15.4 1.59 0.71 0.0247 1.607 4.92 1.4 25.9 PRS_PLINK_1.99526231496888e.08 TRUE 368.2 Diplopia and disorders of binocular vision Both 44 202 7 sense organs darkseagreen4 202, 44 32, 7 60, 10 39, 11 51, 13 0.0843 0.139 0.544 0.264 1.09 0.818 1.4 -0.422 0.581 0.468 0.33 0.656 0.206 2.12 0.257 0.544 0.637 0.196 1.29 0.457 3.79 0.0152 0.555 0.978 0.01 1.02 0.347 3.13 PRS_PLINK_1.99526231496888e.08 TRUE 368.3 Anisometropia Both 20 42 7 sense organs darkseagreen4 42, 20 8, 4 11, 3 9, 2 11, 6 -0.573 0.411 0.163 0.788 0.564 0.253 1.17 -0.152 1.17 0.896 0.047 0.859 0.0501 7.84 -1.17 1.42 0.41 0.388 0.31 0.00185 3.16 0.219 1.35 0.871 0.06 1.25 0.0826 19.9 PRS_PLINK_1.99526231496888e.08 TRUE 368.4 Visual field defects Both 42 184 7 sense organs darkseagreen4 184, 42 24, 5 60, 17 32, 4 46, 11 -0.0208 0.188 0.912 0.04 0.979 0.659 1.38 0.216 0.582 0.711 0.148 1.24 0.421 4.08 -0.714 0.718 0.32 0.495 0.49 0.107 1.98 -0.168 0.6 0.779 0.108 0.845 0.268 2.86 PRS_PLINK_1.99526231496888e.08 TRUE 368.9 Subjective visual disturbances Both 67 244 7 sense organs darkseagreen4 244, 67 36, 8 63, 23 60, 11 59, 22 0.163 0.107 0.127 0.896 1.18 0.958 1.44 0.483 0.479 0.314 0.503 1.62 0.655 4.35 -0.408 0.52 0.433 0.363 0.665 0.241 1.86 0.647 0.498 0.193 0.714 1.91 0.75 5.31 PRS_PLINK_1.99526231496888e.08 FALSE 368.91 Psychophysical visual disturbances Both 5 12 7 sense organs darkseagreen4 12, 5 2, 1 5, 3 1, 0 3, 1 0.196 0.773 0.8 0.097 1.22 0.891 1.3 1.09 2.26 0.631 0.2 2.97 0.000725 8430 0.207 2910 1 0 1.23 0.653 1.86 0.143 4920 1 0 1.15 1.44 2.35 PRS_PLINK_1.99526231496888e.08 TRUE 369 Infection of the eye Both 239 692 7 sense organs darkseagreen4 692, 239 103, 27 232, 79 115, 30 172, 73 0.0688 0.0719 0.338 0.471 1.07 0.926 1.23 0.185 0.262 0.481 0.318 1.2 0.728 2.03 0.0055 0.316 0.986 0.006 1.01 0.54 1.88 0.508 0.27 0.0602 1.22 1.66 0.99 2.85 PRS_PLINK_1.99526231496888e.08 FALSE 369.2 Eye infection, viral Both 39 135 7 sense organs darkseagreen4 135, 39 23, 6 43, 14 25, 6 33, 6 -0.258 0.241 0.286 0.544 0.773 0.482 1.23 0.273 0.571 0.633 0.199 1.31 0.457 4.09 -0.288 0.701 0.682 0.166 0.75 0.18 2.98 -0.434 0.646 0.502 0.3 0.648 0.185 2.23 PRS_PLINK_1.99526231496888e.08 TRUE 369.5 Conjunctivitis, infectious Both 212 644 7 sense organs darkseagreen4 644, 212 97, 25 214, 66 107, 28 160, 67 0.0995 0.0741 0.179 0.746 1.1 0.952 1.27 0.0808 0.274 0.768 0.115 1.08 0.641 1.87 -0.000452 0.328 0.999 0 1 0.524 1.91 0.55 0.282 0.0509 1.294 1.73 1.01 3.05 PRS_PLINK_1.99526231496888e.08 FALSE 370 Keratitis Both 85 280 7 sense organs darkseagreen4 280, 85 42, 10 87, 28 51, 13 70, 26 0.0317 0.132 0.809 0.092 1.03 0.782 1.31 0.387 0.452 0.391 0.408 1.47 0.624 3.69 0.0216 0.477 0.964 0.016 1.02 0.406 2.64 0.428 0.431 0.321 0.493 1.53 0.681 3.64 PRS_PLINK_1.99526231496888e.08 FALSE 370.1 Corneal ulcer Both 17 55 7 sense organs darkseagreen4 55, 17 12, 0 16, 4 10, 4 14, 8 0.194 0.224 0.386 0.413 1.21 0.825 1.87 1.5 1.39 0.282 0.55 4.47 0.434 14200 2.72 1.83 0.137 0.862 15.3 0.882 1580000 4.37 1.96 0.0258 1.588 78.7 3.54 819000 PRS_PLINK_1.99526231496888e.08 TRUE 370.2 Superficial keratitis Both 35 98 7 sense organs darkseagreen4 98, 35 11, 7 29, 12 19, 3 25, 10 -0.227 0.231 0.325 0.488 0.797 0.48 1.19 -0.215 0.732 0.769 0.114 0.806 0.204 3.3 -1.12 0.817 0.17 0.769 0.326 0.0544 1.45 -0.826 0.741 0.265 0.577 0.438 0.0972 1.75 PRS_PLINK_1.99526231496888e.08 TRUE 370.3 Keratoconjunctivitis Both 29 123 7 sense organs darkseagreen4 123, 29 20, 4 40, 12 21, 4 31, 5 -0.36 0.285 0.205 0.688 0.697 0.394 1.21 0.672 0.72 0.35 0.456 1.96 0.52 8.88 0.0728 0.729 0.921 0.036 1.08 0.259 4.52 -0.633 0.737 0.39 0.408 0.531 0.113 2.29 PRS_PLINK_1.99526231496888e.08 TRUE 370.31 Keratoconjunctivitis sicca Both 10 22 7 sense organs darkseagreen4 22, 10 4, 1 5, 3 5, 3 6, 2 -0.258 0.644 0.688 0.162 0.772 0.203 2.51 0.273 1.85 0.883 0.054 1.31 0.00161 46.3 1.77 2.15 0.409 0.388 5.9 0.291 19700 0.21 3.85 0.957 0.019 1.23 0.0354 9740 PRS_PLINK_1.99526231496888e.08 TRUE 371 Inflammation of the eye Both 259 640 7 sense organs darkseagreen4 640, 259 99, 25 213, 97 106, 39 159, 70 0.108 0.0774 0.163 0.787 1.11 0.955 1.29 0.486 0.263 0.0648 1.188 1.63 0.985 2.75 0.326 0.307 0.288 0.54 1.39 0.764 2.55 0.528 0.276 0.0557 1.254 1.7 1 2.94 PRS_PLINK_1.99526231496888e.08 FALSE 371.1 Uveitis, noninfectious or NOS Both 21 108 7 sense organs darkseagreen4 108, 21 19, 0 27, 8 27, 8 27, 3 0.015 0.241 0.95 0.022 1.02 0.55 1.51 1.51 1.21 0.211 0.676 4.54 0.48 501 2.13 1.13 0.0598 1.223 8.38 1.23 801 0.798 1.24 0.52 0.284 2.22 0.0245 276 PRS_PLINK_1.99526231496888e.08 TRUE 371.2 Conjunctivitis, noninfectious Both 81 235 7 sense organs darkseagreen4 235, 81 41, 11 76, 25 42, 10 58, 23 0.0313 0.171 0.855 0.068 1.03 0.741 1.44 0.102 0.451 0.821 0.086 1.11 0.468 2.71 -0.195 0.524 0.71 0.149 0.823 0.285 2.33 0.733 0.472 0.12 0.92 2.08 0.86 5.42 PRS_PLINK_1.99526231496888e.08 FALSE 371.21 Allergic conjunctivitis Both 69 205 7 sense organs darkseagreen4 205, 69 38, 9 68, 21 33, 5 51, 23 0.0327 0.186 0.86 0.065 1.03 0.721 1.49 0.207 0.476 0.664 0.178 1.23 0.495 3.2 -0.719 0.65 0.269 0.571 0.487 0.111 1.75 0.833 0.482 0.0842 1.075 2.3 0.934 6.13 PRS_PLINK_1.99526231496888e.08 FALSE 371.3 Inflammation of eyelids Both 187 485 7 sense organs darkseagreen4 485, 187 83, 22 154, 65 86, 30 118, 48 0.0921 0.0868 0.289 0.54 1.1 0.919 1.29 0.342 0.289 0.236 0.627 1.41 0.81 2.51 0.164 0.332 0.622 0.206 1.18 0.618 2.26 0.332 0.303 0.272 0.565 1.39 0.779 2.55 PRS_PLINK_1.99526231496888e.08 FALSE 371.33 Noninfectious dermatoses of eyelid Both 16 30 7 sense organs darkseagreen4 30, 16 3, 1 7, 3 7, 4 8, 5 -0.00938 0.495 0.985 0.007 0.991 0.389 2.53 -0.441 2.02 0.827 0.083 0.643 0.00698 18.3 -1.16 1.93 0.547 0.262 0.313 7.67e-06 8.2 -0.995 2.14 0.641 0.193 0.37 0.00693 10.4 PRS_PLINK_1.99526231496888e.08 TRUE 372 Disorders of conjunctiva Both 39 169 7 sense organs darkseagreen4 169, 39 26, 3 49, 15 35, 9 42, 7 -0.145 0.209 0.49 0.31 0.865 0.542 1.25 0.64 0.656 0.329 0.482 1.9 0.56 7.92 0.953 0.789 0.227 0.644 2.59 0.593 14 -0.127 0.743 0.865 0.063 0.881 0.2 4.33 PRS_PLINK_1.99526231496888e.08 TRUE 374 Other disorders of eyelids Both 141 396 7 sense organs darkseagreen4 396, 141 62, 12 128, 49 68, 26 98, 35 0.152 0.0958 0.112 0.953 1.16 0.964 1.4 0.479 0.371 0.196 0.708 1.62 0.802 3.43 0.773 0.418 0.064 1.194 2.17 0.982 5.05 0.663 0.394 0.0923 1.035 1.94 0.924 4.34 PRS_PLINK_1.99526231496888e.08 FALSE 374.1 Ectropion or entropion Both 10 59 7 sense organs darkseagreen4 59, 10 4, 0 15, 3 15, 2 14, 5 1.29 0.57 0.0232 1.634 3.65 1.22 14.3 0.917 1.64 0.577 0.239 2.5 0.207 881 -0.161 1.79 0.928 0.032 0.851 0.00108 54100 3 2.6 0.25 0.602 20 0.367 53800 PRS_PLINK_1.99526231496888e.08 TRUE 374.2 Lagophthalmos Both 4 46 7 sense organs darkseagreen4 46, 4 7, 0 15, 1 7, 1 12, 1 -0.748 0.888 0.4 0.398 0.473 0.0379 3.12 -0.528 1.86 0.777 0.11 0.59 3.64e-05 133 1.46 2.1 0.487 0.313 4.31 0.152 325 -0.287 2.19 0.895 0.048 0.75 2.05e-05 974 PRS_PLINK_1.99526231496888e.08 TRUE 374.3 Ptosis of eyelid Both 51 146 7 sense organs darkseagreen4 146, 51 23, 8 45, 17 26, 10 37, 12 0.0181 0.178 0.919 0.037 1.02 0.699 1.4 0.166 0.525 0.752 0.124 1.18 0.445 3.33 0.0405 0.594 0.946 0.024 1.04 0.341 3.29 -0.173 0.56 0.758 0.12 0.841 0.293 2.46 PRS_PLINK_1.99526231496888e.08 FALSE 374.6 Dermatochalasis Both 51 107 7 sense organs darkseagreen4 107, 51 18, 8 33, 15 21, 11 26, 12 0.0485 0.238 0.839 0.076 1.05 0.666 1.67 -0.0247 0.552 0.964 0.016 0.976 0.351 2.82 0.0253 0.591 0.966 0.015 1.03 0.347 3.06 0.141 0.628 0.823 0.085 1.15 0.363 3.86 PRS_PLINK_1.99526231496888e.08 FALSE 375 Disorders of lacrimal system Both 209 528 7 sense organs darkseagreen4 528, 209 85, 27 176, 65 85, 36 132, 52 -0.0795 0.0979 0.417 0.38 0.924 0.757 1.11 0.116 0.287 0.685 0.164 1.12 0.648 1.98 0.404 0.335 0.228 0.642 1.5 0.785 2.9 0.202 0.298 0.499 0.302 1.22 0.689 2.2 PRS_PLINK_1.99526231496888e.08 FALSE 375.1 Dry eyes Both 240 550 7 sense organs darkseagreen4 550, 240 87, 31 186, 79 85, 38 138, 60 -0.00446 0.0825 0.957 0.019 0.996 0.842 1.16 0.145 0.271 0.591 0.228 1.16 0.687 1.97 0.344 0.319 0.281 0.552 1.41 0.762 2.64 0.307 0.281 0.274 0.562 1.36 0.794 2.36 PRS_PLINK_1.99526231496888e.08 FALSE 375.2 Epiphora Both 22 75 7 sense organs darkseagreen4 75, 22 12, 2 24, 5 13, 2 19, 8 -0.0615 0.329 0.852 0.07 0.94 0.501 1.77 0.668 1 0.505 0.296 1.95 0.313 21.1 -0.148 1.07 0.89 0.05 0.863 0.0465 7.52 -0.41 0.97 0.673 0.172 0.664 0.0921 4.47 PRS_PLINK_1.99526231496888e.08 TRUE 376 Disorders of the orbit Both 9 81 7 sense organs darkseagreen4 81, 9 14, 2 22, 2 18, 4 20, 1 0.119 0.263 0.653 0.185 1.13 0.521 1.71 -1.59 1.46 0.274 0.562 0.204 3.21e-06 2.96 -0.166 1.03 0.872 0.059 0.847 0.0855 7.01 -1.25 1.2 0.296 0.528 0.286 0.017 3.06 PRS_PLINK_1.99526231496888e.08 TRUE 377 Disorders of optic nerve and visual pathways Both 46 172 7 sense organs darkseagreen4 172, 46 25, 4 59, 17 26, 8 43, 14 0.224 0.213 0.293 0.534 1.25 0.824 1.89 0.618 0.618 0.317 0.499 1.86 0.6 6.96 1.07 0.743 0.151 0.821 2.91 0.751 15.2 0.449 0.609 0.461 0.336 1.57 0.508 5.58 PRS_PLINK_1.99526231496888e.08 TRUE 377.1 Optic atrophy Both 19 49 7 sense organs darkseagreen4 49, 19 10, 4 13, 1 11, 9 12, 5 0.867 0.515 0.0923 1.035 2.38 0.935 7.06 -2.18 1.99 0.274 0.563 0.113 1.03e-08 10 1.63 1.23 0.183 0.736 5.1 0.624 86.2 -0.304 1.31 0.817 0.088 0.738 0.0594 21.6 PRS_PLINK_1.99526231496888e.08 TRUE 377.3 Optic neuritis/neuropathy Both 26 129 7 sense organs darkseagreen4 129, 26 22, 3 42, 11 21, 3 31, 7 -0.0559 0.273 0.838 0.077 0.946 0.541 1.59 0.592 0.729 0.417 0.38 1.81 0.459 9.02 0.189 0.874 0.829 0.081 1.21 0.214 8.44 0.232 0.726 0.749 0.125 1.26 0.322 5.78 PRS_PLINK_1.99526231496888e.08 TRUE 378 Strabismus and other disorders of binocular eye movements Both 58 233 7 sense organs darkseagreen4 233, 58 35, 7 83, 14 33, 8 58, 23 0.18 0.111 0.106 0.974 1.2 0.981 1.5 -0.353 0.517 0.495 0.306 0.702 0.257 2.01 0.34 0.604 0.574 0.241 1.41 0.443 4.63 0.554 0.515 0.281 0.551 1.74 0.666 4.94 PRS_PLINK_1.99526231496888e.08 FALSE 378.1 Strabismus (not specified as paralytic) Both 44 153 7 sense organs darkseagreen4 153, 44 24, 6 54, 9 21, 6 38, 17 0.104 0.121 0.39 0.409 1.11 0.883 1.39 -0.288 0.623 0.644 0.191 0.75 0.222 2.59 0.614 0.767 0.423 0.373 1.85 0.428 9.24 0.383 0.601 0.524 0.28 1.47 0.477 4.8 PRS_PLINK_1.99526231496888e.08 TRUE 378.2 Nystagmus and other irregular eye movements Both 10 45 7 sense organs darkseagreen4 45, 10 7, 3 17, 2 5, 2 11, 2 -0.228 0.469 0.627 0.203 0.796 0.322 1.92 -1.47 1.32 0.267 0.573 0.23 0.000376 2.5 -2.13 2.43 0.382 0.418 0.119 1.21e-06 5.01 -0.609 1.22 0.616 0.21 0.544 0.0514 4.27 PRS_PLINK_1.99526231496888e.08 TRUE 378.5 Paralytic strabismus Both 13 47 7 sense organs darkseagreen4 47, 13 8, 0 20, 2 3, 2 12, 7 0.383 0.346 0.268 0.571 1.47 0.848 3.57 0.571 1.59 0.719 0.143 1.77 0.0827 8680 1.02 5.21 0.845 0.073 2.78 2.09e-05 17800000 2.44 1.75 0.163 0.788 11.5 0.699 8350 PRS_PLINK_1.99526231496888e.08 TRUE 379 Other disorders of eye Both 236 551 7 sense organs darkseagreen4 551, 236 88, 36 186, 72 85, 40 136, 60 0.021 0.0743 0.778 0.109 1.02 0.877 1.17 -0.232 0.255 0.364 0.439 0.793 0.484 1.31 0.0546 0.291 0.851 0.07 1.06 0.601 1.86 0.0611 0.259 0.814 0.09 1.06 0.645 1.76 PRS_PLINK_1.99526231496888e.08 FALSE 379.1 Scleritis and episcleritis Both 13 46 7 sense organs darkseagreen4 46, 13 3, 2 11, 1 11, 0 12, 9 0.585 0.331 0.0776 1.11 1.8 1.07 5.7 -0.336 2.2 0.879 0.056 0.714 0.00277 27500 -0.378 3.42 0.912 0.04 0.685 9.2e-05 635 0.0899 1.46 0.951 0.022 1.09 0.0935 13.5 PRS_PLINK_1.99526231496888e.08 TRUE 379.2 Disorders of vitreous body Both 151 335 7 sense organs darkseagreen4 335, 151 57, 19 113, 52 51, 28 83, 37 0.0362 0.0901 0.688 0.163 1.04 0.857 1.22 0.103 0.339 0.761 0.119 1.11 0.579 2.16 0.489 0.392 0.211 0.675 1.63 0.775 3.51 0.219 0.35 0.532 0.274 1.24 0.639 2.47 PRS_PLINK_1.99526231496888e.08 FALSE 379.3 Aphakia and other disorders of lens Both 5 23 7 sense organs darkseagreen4 23, 5 4, 0 6, 2 5, 2 6, 1 0.175 0.986 0.859 0.066 1.19 0.18 12.4 3.4 4.86 0.484 0.315 30 0.00301 452000 1.09 7.07 0.877 0.057 2.99 3.98e-05 685000 0.762 20.1 0.97 0.013 2.14 2 2.3 PRS_PLINK_1.99526231496888e.08 TRUE 379.4 Anomalies of pupillary function Both 16 53 7 sense organs darkseagreen4 53, 16 10, 1 13, 5 11, 2 13, 6 0.242 0.444 0.585 0.233 1.27 0.553 3.1 0.807 1.08 0.454 0.343 2.24 0.331 21.3 0.924 1.46 0.526 0.279 2.52 0.208 67.2 -0.046 1.28 0.971 0.013 0.955 0.00821 11.2 PRS_PLINK_1.99526231496888e.08 TRUE 379.5 Disorders of iris and ciliary body Both 13 45 7 sense organs darkseagreen4 45, 13 7, 1 12, 3 10, 4 11, 4 0.0705 0.42 0.867 0.062 1.07 0.485 2.43 0.0411 1.41 0.977 0.01 1.04 0.0685 30.5 -0.43 1.62 0.791 0.102 0.651 0.00944 77.9 0.189 1.59 0.905 0.043 1.21 0.0771 34.3 PRS_PLINK_1.99526231496888e.08 TRUE 379.51 Pigmentary iris degeneration Both 3 11 7 sense organs darkseagreen4 11, 3 3, 1 4, 0 1, 0 3, 1 0.579 1.3 0.657 0.182 1.78 0.23 35.3 0.0177 835 1 0 1.02 0.928 0.939 0.124 1490 1 0 1.13 0.47 1.48 0.442 914 1 0 1.56 1.06 0.75 PRS_PLINK_1.99526231496888e.08 TRUE 379.9 Pain, swelling or discharge of eye Both 101 258 7 sense organs darkseagreen4 258, 101 36, 9 82, 37 49, 15 62, 29 0.0109 0.105 0.917 0.037 1.01 0.811 1.22 0.584 0.434 0.178 0.749 1.79 0.799 4.32 -0.00155 0.535 0.998 0.001 0.998 0.353 2.88 0.132 0.465 0.776 0.11 1.14 0.467 2.9 PRS_PLINK_1.99526231496888e.08 FALSE 380 Disorders of external ear Both 96 398 7 sense organs darkseagreen4 398, 96 56, 13 135, 39 64, 13 99, 23 0.0131 0.116 0.911 0.041 1.01 0.788 1.25 0.144 0.367 0.695 0.158 1.15 0.577 2.41 -0.19 0.444 0.669 0.175 0.827 0.344 1.98 0.0621 0.387 0.872 0.059 1.06 0.507 2.31 PRS_PLINK_1.99526231496888e.08 FALSE 380.1 Otitis externa Both 111 378 7 sense organs darkseagreen4 378, 111 58, 14 122, 43 66, 20 93, 20 -0.0978 0.137 0.477 0.322 0.907 0.688 1.18 0.318 0.355 0.371 0.431 1.37 0.698 2.82 0.401 0.431 0.352 0.453 1.49 0.649 3.58 -0.0159 0.397 0.968 0.014 0.984 0.457 2.17 PRS_PLINK_1.99526231496888e.08 FALSE 380.4 Impacted cerumen Both 136 474 7 sense organs darkseagreen4 474, 136 71, 19 159, 55 76, 22 119, 29 -0.0221 0.109 0.84 0.076 0.978 0.777 1.19 0.213 0.313 0.496 0.304 1.24 0.681 2.31 0.121 0.367 0.742 0.13 1.13 0.554 2.32 -0.0801 0.337 0.812 0.091 0.923 0.481 1.8 PRS_PLINK_1.99526231496888e.08 FALSE 381 Otitis media and Eustachian tube disorders Both 273 878 7 sense organs darkseagreen4 878, 273 120, 38 290, 96 150, 50 218, 63 -0.00558 0.0695 0.936 0.029 0.994 0.861 1.13 -0.0223 0.227 0.922 0.035 0.978 0.631 1.53 0.00566 0.252 0.982 0.008 1.01 0.617 1.65 -0.106 0.239 0.656 0.183 0.899 0.566 1.44 PRS_PLINK_1.99526231496888e.08 FALSE 381.1 Otitis media Both 198 802 7 sense organs darkseagreen4 802, 198 110, 30 264, 69 135, 32 201, 44 -0.0484 0.082 0.555 0.256 0.953 0.801 1.11 -0.135 0.254 0.596 0.225 0.874 0.535 1.45 -0.283 0.296 0.339 0.47 0.753 0.422 1.34 -0.264 0.271 0.329 0.483 0.768 0.453 1.31 PRS_PLINK_1.99526231496888e.08 FALSE 381.11 Suppurative and unspecified otitis media Both 168 696 7 sense organs darkseagreen4 696, 168 95, 26 229, 57 119, 28 174, 38 -0.0879 0.0991 0.375 0.426 0.916 0.747 1.1 -0.17 0.274 0.535 0.271 0.844 0.497 1.46 -0.279 0.313 0.373 0.428 0.757 0.41 1.39 -0.352 0.293 0.229 0.639 0.703 0.397 1.25 PRS_PLINK_1.99526231496888e.08 FALSE 381.2 Eustachian tube disorders Both 131 488 7 sense organs darkseagreen4 488, 131 70, 15 157, 47 85, 19 120, 37 -0.0302 0.109 0.782 0.107 0.97 0.768 1.18 0.198 0.335 0.555 0.256 1.22 0.643 2.4 -0.00543 0.382 0.989 0.005 0.995 0.472 2.12 0.184 0.349 0.599 0.222 1.2 0.615 2.42 PRS_PLINK_1.99526231496888e.08 FALSE 381.3 Mastoiditis & related conditions Both 8 31 7 sense organs darkseagreen4 31, 8 5, 1 9, 2 6, 1 8, 3 0.0565 0.577 0.922 0.035 1.06 0.372 3.23 1.14 2.43 0.639 0.194 3.12 0.0885 1090000 0.0572 1.5 0.969 0.013 1.06 0.0841 12.2 0.287 1.71 0.867 0.062 1.33 0.0636 36.6 PRS_PLINK_1.99526231496888e.08 TRUE 381.9 Otorrhea Both 12 86 7 sense organs darkseagreen4 86, 12 12, 2 30, 3 12, 1 22, 5 0.258 0.412 0.531 0.275 1.29 0.574 3.04 -1.85 1.52 0.225 0.648 0.158 0.000801 2.76 -1.34 1.58 0.393 0.405 0.261 9.58e-05 5.01 0.546 0.973 0.575 0.241 1.73 0.282 13.7 PRS_PLINK_1.99526231496888e.08 TRUE 382 Otalgia Both 146 562 7 sense organs darkseagreen4 562, 146 83, 22 168, 50 110, 25 140, 32 -0.129 0.11 0.242 0.616 0.879 0.701 1.08 0.0482 0.296 0.871 0.06 1.05 0.594 1.89 -0.119 0.338 0.725 0.14 0.888 0.457 1.73 -0.245 0.319 0.441 0.355 0.782 0.419 1.47 PRS_PLINK_1.99526231496888e.08 FALSE 383 Otosclerosis Both 3 39 7 sense organs darkseagreen4 39, 3 7, 0 13, 2 6, 1 9, 0 -0.885 0.97 0.362 0.442 0.413 0.00406 2.9 0.215 1.48 0.885 0.053 1.24 0.0498 51 1.54 2.94 0.602 0.22 4.64 0.025 6050 PRS_PLINK_1.99526231496888e.08 TRUE 384 Other disorders of tympanic membrane Both 18 122 7 sense organs darkseagreen4 122, 18 16, 2 35, 5 24, 4 31, 4 0.104 0.318 0.744 0.129 1.11 0.59 2.12 -0.11 0.852 0.897 0.047 0.895 0.164 5.81 0.207 0.83 0.803 0.095 1.23 0.258 7.64 -0.339 1.03 0.743 0.129 0.713 0.0731 6.77 PRS_PLINK_1.99526231496888e.08 TRUE 384.1 Myringitis Both 4 8 7 sense organs darkseagreen4 8, 4 1, 0 2, 0 2, 2 2, 1 -0.0312 29.7 0.999 0 0.969 0.562 2.04 -0.0106 23.9 1 0 0.989 0.838 1.23 -0.00413 31.9 1 0 0.996 0.897 1.13 PRS_PLINK_1.99526231496888e.08 TRUE 384.4 Perforation of tympanic membrane Both 12 96 7 sense organs darkseagreen4 96, 12 10, 1 26, 2 22, 5 24, 2 0.442 0.397 0.266 0.576 1.56 0.712 3.7 -0.35 1.13 0.756 0.121 0.705 0.0586 8.76 0.848 1.07 0.429 0.367 2.34 0.34 27.4 -1.14 1.38 0.408 0.39 0.318 0.00257 9.62 PRS_PLINK_1.99526231496888e.08 TRUE 385 Other disorders of middle ear and mastoid Both 17 98 7 sense organs darkseagreen4 98, 17 12, 2 36, 7 12, 4 25, 4 0.0835 0.389 0.83 0.081 1.09 0.51 2.42 -0.0351 0.881 0.968 0.014 0.966 0.2 6.19 0.678 1.25 0.589 0.23 1.97 0.187 111000 0.61 1.03 0.553 0.257 1.84 0.293 21.2 PRS_PLINK_1.99526231496888e.08 TRUE 385.3 Cholesteatoma Both 8 64 7 sense organs darkseagreen4 64, 8 5, 0 24, 3 8, 2 16, 3 0.687 0.546 0.208 0.682 1.99 0.674 7.1 2.17 2.17 0.317 0.499 8.74 0.213 4520000 -0.89 3.96 0.822 0.085 0.411 9.32e-05 4240 1.61 1.89 0.393 0.405 5.02 0.211 3380 PRS_PLINK_1.99526231496888e.08 TRUE 385.5 Tympanosclerosis and middle ear disease related to otitis media Both 3 27 7 sense organs darkseagreen4 27, 3 4, 0 13, 2 0, 1 7, 0 -0.209 0.837 0.802 0.096 0.811 0.144 4.2 0.628 2.33 0.787 0.104 1.87 0.0283 143000 -0.0287 575 1 0 0.972 0.555 1.66 PRS_PLINK_1.99526231496888e.08 TRUE 386 Vertiginous syndromes and other disorders of vestibular system Both 99 390 7 sense organs darkseagreen4 390, 99 58, 11 131, 33 65, 14 96, 28 0.089 0.0987 0.367 0.435 1.09 0.899 1.31 0.187 0.387 0.63 0.201 1.21 0.579 2.65 0.0453 0.433 0.917 0.038 1.05 0.449 2.48 0.391 0.417 0.349 0.457 1.48 0.668 3.46 PRS_PLINK_1.99526231496888e.08 FALSE 386.1 Meniere's disease Both 11 66 7 sense organs darkseagreen4 66, 11 10, 1 16, 4 17, 3 16, 3 0.472 0.453 0.297 0.527 1.6 0.662 4.48 0.433 1.13 0.701 0.154 1.54 0.195 21.9 1.24 1.36 0.36 0.444 3.47 0.261 359 1.1 1.87 0.559 0.253 2.99 0.00559 8.04 PRS_PLINK_1.99526231496888e.08 TRUE 386.2 Peripheral or central vertigo Both 84 320 7 sense organs darkseagreen4 320, 84 50, 10 97, 24 62, 13 79, 25 0.1 0.102 0.325 0.488 1.11 0.904 1.34 0.136 0.419 0.746 0.128 1.15 0.515 2.69 0.031 0.457 0.946 0.024 1.03 0.425 2.57 0.366 0.446 0.411 0.386 1.44 0.619 3.56 PRS_PLINK_1.99526231496888e.08 FALSE 386.21 Central origin vertigo Both 62 239 7 sense organs darkseagreen4 239, 62 39, 7 76, 21 42, 7 60, 19 0.2 0.138 0.149 0.828 1.22 0.945 1.61 0.26 0.498 0.601 0.221 1.3 0.504 3.59 -0.128 0.585 0.827 0.083 0.88 0.272 2.82 0.309 0.529 0.56 0.252 1.36 0.497 3.98 PRS_PLINK_1.99526231496888e.08 FALSE 386.3 Labyrinthitis Both 76 309 7 sense organs darkseagreen4 309, 76 46, 8 104, 30 51, 8 76, 21 0.164 0.129 0.202 0.694 1.18 0.923 1.51 0.379 0.443 0.392 0.407 1.46 0.638 3.64 -0.089 0.536 0.868 0.061 0.915 0.315 2.64 0.43 0.5 0.39 0.409 1.54 0.598 4.31 PRS_PLINK_1.99526231496888e.08 FALSE 386.9 Dizziness and giddiness (Light-headedness and vertigo) Both 377 868 7 sense organs darkseagreen4 868, 377 124, 43 280, 147 154, 55 217, 94 -0.0344 0.0668 0.607 0.217 0.966 0.843 1.1 0.357 0.211 0.0906 1.043 1.43 0.952 2.17 -0.0101 0.244 0.967 0.015 0.99 0.617 1.59 0.159 0.224 0.477 0.321 1.17 0.761 1.82 PRS_PLINK_1.99526231496888e.08 FALSE 388 Other disorders of ear Both 53 257 7 sense organs darkseagreen4 257, 53 43, 15 85, 9 42, 10 64, 16 0.0729 0.148 0.622 0.206 1.08 0.755 1.37 -0.886 0.473 0.061 1.214 0.412 0.158 1.03 -0.616 0.527 0.242 0.615 0.54 0.185 1.49 -0.159 0.428 0.71 0.148 0.853 0.374 1.96 PRS_PLINK_1.99526231496888e.08 FALSE 389 Hearing loss Both 286 955 7 sense organs darkseagreen4 955, 286 144, 38 320, 92 157, 46 238, 75 -0.0147 0.0761 0.847 0.072 0.985 0.842 1.14 0.0215 0.232 0.926 0.033 1.02 0.653 1.62 -0.0219 0.265 0.934 0.03 0.978 0.582 1.65 0.094 0.236 0.69 0.161 1.1 0.696 1.75 PRS_PLINK_1.99526231496888e.08 FALSE 389.1 Sensorineural hearing loss Both 146 565 7 sense organs darkseagreen4 565, 146 87, 19 190, 48 88, 21 141, 41 0.0486 0.0962 0.614 0.212 1.05 0.853 1.25 0.201 0.319 0.529 0.277 1.22 0.666 2.32 0.0526 0.365 0.885 0.053 1.05 0.515 2.17 0.266 0.326 0.415 0.382 1.3 0.698 2.51 PRS_PLINK_1.99526231496888e.08 FALSE 389.2 Conductive hearing loss Both 32 256 7 sense organs darkseagreen4 256, 32 40, 6 65, 6 63, 8 64, 11 0.19 0.187 0.31 0.509 1.21 0.812 1.69 -0.562 0.64 0.38 0.42 0.57 0.155 2.06 -0.685 0.63 0.277 0.558 0.504 0.139 1.78 0.0736 0.568 0.897 0.047 1.08 0.365 3.42 PRS_PLINK_1.99526231496888e.08 TRUE 389.3 Degenerative and vascular disorders of ear Both 6 37 7 sense organs darkseagreen4 37, 6 8, 1 9, 2 9, 1 9, 2 0.433 0.67 0.518 0.285 1.54 0.453 7.16 0.346 1.45 0.812 0.09 1.41 0.0725 288000 -0.344 1.5 0.819 0.087 0.709 0.042 18.1 2.96 2.32 0.202 0.695 19.2 0.349 8.24e+08 PRS_PLINK_1.99526231496888e.08 TRUE 389.4 Tinnitus Both 110 457 7 sense organs darkseagreen4 457, 110 67, 14 159, 29 68, 22 114, 29 -0.0287 0.14 0.838 0.077 0.972 0.739 1.28 -0.112 0.371 0.762 0.118 0.894 0.436 1.9 0.23 0.404 0.569 0.245 1.26 0.57 2.81 0.00389 0.374 0.992 0.004 1 0.486 2.13 PRS_PLINK_1.99526231496888e.08 FALSE 389.5 Disorders of acoustic nerve Both 7 42 7 sense organs darkseagreen4 42, 7 9, 2 9, 1 10, 2 11, 1 -0.217 0.602 0.719 0.144 0.805 0.204 2.69 -2.11 1.79 0.238 0.624 0.121 1.74e-05 2.44 -0.566 1.43 0.692 0.16 0.568 0.0189 9.11 -0.926 1.41 0.51 0.292 0.396 0.000997 4.58 PRS_PLINK_1.99526231496888e.08 TRUE 394 Rheumatic disease of the heart valves Both 38 213 8 circulatory system red 213, 38 33, 11 70, 10 37, 6 52, 8 -0.0899 0.236 0.703 0.153 0.914 0.575 1.46 -1.03 0.521 0.0476 1.323 0.356 0.125 0.968 -0.162 0.606 0.789 0.103 0.85 0.259 2.75 -1.34 0.612 0.028 1.552 0.261 0.0743 0.817 PRS_PLINK_1.99526231496888e.08 TRUE 394.1 Mitral valve stenosis and aortic valve stenosis Both 12 39 8 circulatory system red 39, 12 7, 3 10, 4 9, 2 10, 1 -0.59 0.545 0.279 0.555 0.554 0.188 1.49 -0.125 1.08 0.908 0.042 0.883 0.135 6.78 -1.24 1.29 0.338 0.471 0.289 0.0174 2.65 -1.88 1.48 0.204 0.691 0.153 0.00138 1.5 PRS_PLINK_1.99526231496888e.08 TRUE 394.2 Mitral valve disease Both 8 62 8 circulatory system red 62, 8 11, 1 16, 4 14, 2 16, 0 -0.652 0.552 0.237 0.625 0.521 0.162 1.54 0.895 1.33 0.5 0.301 2.45 0.221 199 1.08 1.47 0.463 0.335 2.95 0.218 1310 -0.695 1.34 0.605 0.218 0.499 0.00608 14.9 PRS_PLINK_1.99526231496888e.08 TRUE 394.3 Aortic valve disease Both 4 18 8 circulatory system red 18, 4 2, 0 5, 2 3, 1 5, 1 0.21 1.03 0.837 0.077 1.23 0.183 10.5 -3.9 15.6 0.803 0.095 0.0203 0.0137 0.0316 13.1 8910 0.999 0.001 479000 2.29e-13 6.03e+19 3.23 189 0.986 0.006 25.2 0.4 41.2 PRS_PLINK_1.99526231496888e.08 TRUE 394.4 Acute rheumatic heart disease Both 1 7 8 circulatory system red 7, 1 1, 0 2, 0 1, 0 2, 1 -0.617 40.6 0.988 0.005 0.54 0.0338 7.82 0.442 2.84e+08 1 0 1.56 0.0226 62.5 PRS_PLINK_1.99526231496888e.08 TRUE 394.7 Disease of tricuspid valve Both 18 92 8 circulatory system red 92, 18 18, 6 22, 1 23, 3 23, 6 -0.0836 0.401 0.835 0.078 0.92 0.411 2.02 -1.63 1.04 0.117 0.93 0.196 0.0134 1.55 -0.412 0.885 0.642 0.192 0.663 0.112 3.59 -0.318 0.844 0.706 0.151 0.728 0.139 3.8 PRS_PLINK_1.99526231496888e.08 TRUE 395 Heart valve disorders Both 106 553 8 circulatory system red 553, 106 81, 17 184, 33 90, 20 138, 27 0.136 0.107 0.203 0.693 1.15 0.921 1.4 -0.354 0.347 0.307 0.513 0.702 0.36 1.4 0.0214 0.37 0.954 0.021 1.02 0.496 2.12 -0.13 0.344 0.707 0.151 0.879 0.452 1.74 PRS_PLINK_1.99526231496888e.08 FALSE 395.1 Nonrheumatic mitral valve disorders Both 70 394 8 circulatory system red 394, 70 55, 11 132, 20 64, 14 99, 18 0.135 0.166 0.416 0.381 1.14 0.826 1.59 -0.399 0.422 0.344 0.463 0.671 0.296 1.57 -0.117 0.449 0.794 0.1 0.89 0.368 2.16 -0.137 0.418 0.743 0.129 0.872 0.388 2.02 PRS_PLINK_1.99526231496888e.08 FALSE 395.2 Nonrheumatic aortic valve disorders Both 42 223 8 circulatory system red 223, 42 31, 7 76, 18 36, 8 55, 7 -0.0956 0.233 0.681 0.167 0.909 0.575 1.44 -0.0474 0.511 0.926 0.033 0.954 0.363 2.67 0.661 0.687 0.336 0.474 1.94 0.532 8.41 -0.484 0.587 0.409 0.388 0.616 0.191 1.98 PRS_PLINK_1.99526231496888e.08 TRUE 395.3 Nonrheumatic tricuspid valve disorders Both 17 85 8 circulatory system red 85, 17 17, 3 24, 4 18, 5 21, 4 0.413 0.261 0.114 0.944 1.51 0.97 2.58 -0.517 0.965 0.592 0.228 0.596 0.0632 4.12 0.51 0.87 0.558 0.254 1.66 0.336 9.24 -0.836 1.03 0.416 0.381 0.433 0.0446 3.1 PRS_PLINK_1.99526231496888e.08 TRUE 395.4 Nonrheumatic pulmonary valve disorders Both 4 36 8 circulatory system red 36, 4 5, 0 10, 0 8, 1 9, 2 0.277 0.619 0.655 0.184 1.32 0.381 4.95 -0.101 1.98 0.959 0.018 0.904 0.000106 98.3 0.702 1.78 0.693 0.159 2.02 0.0474 542 PRS_PLINK_1.99526231496888e.08 TRUE 395.6 Heart valve replaced Both 18 129 8 circulatory system red 129, 18 23, 4 43, 5 20, 3 32, 5 0.211 0.361 0.56 0.252 1.23 0.608 2.63 -1.27 0.81 0.116 0.937 0.28 0.0447 1.55 0.587 0.92 0.523 0.281 1.8 0.305 12.4 -0.103 0.719 0.886 0.052 0.902 0.214 3.92 PRS_PLINK_1.99526231496888e.08 TRUE 396 Abnormal heart sounds Both 152 908 8 circulatory system red 908, 152 127, 24 297, 58 157, 25 226, 29 0.00205 0.0926 0.982 0.008 1 0.823 1.19 -0.106 0.271 0.696 0.158 0.899 0.533 1.55 -0.157 0.31 0.613 0.212 0.855 0.464 1.58 -0.524 0.306 0.0862 1.064 0.592 0.323 1.09 PRS_PLINK_1.99526231496888e.08 FALSE 401 Hypertension Both 502 767 8 circulatory system red 767, 502 107, 53 261, 185 121, 72 192, 144 -0.0314 0.0644 0.626 0.204 0.969 0.852 1.1 0.277 0.219 0.206 0.685 1.32 0.864 2.03 0.229 0.254 0.367 0.436 1.26 0.769 2.07 0.369 0.22 0.0931 1.031 1.45 0.946 2.23 PRS_PLINK_1.99526231496888e.08 FALSE 401.1 Essential hypertension Both 499 767 8 circulatory system red 767, 499 107, 52 261, 184 121, 72 192, 143 -0.0275 0.0645 0.669 0.175 0.973 0.855 1.1 0.298 0.22 0.177 0.752 1.35 0.88 2.08 0.271 0.256 0.291 0.537 1.31 0.798 2.17 0.39 0.221 0.0771 1.113 1.48 0.964 2.28 PRS_PLINK_1.99526231496888e.08 FALSE 401.2 Hypertensive heart and/or renal disease Both 75 334 8 circulatory system red 334, 75 53, 14 114, 25 52, 11 83, 19 -0.055 0.127 0.665 0.177 0.947 0.703 1.18 -0.239 0.392 0.543 0.265 0.787 0.371 1.71 -0.177 0.479 0.711 0.148 0.837 0.324 2.11 -0.237 0.407 0.56 0.252 0.789 0.358 1.75 PRS_PLINK_1.99526231496888e.08 FALSE 401.21 Hypertensive heart disease Both 24 114 8 circulatory system red 114, 24 15, 7 30, 5 26, 5 29, 6 8.27e-05 0.2 1 0 1 0.577 1.37 -1.34 0.79 0.0894 1.048 0.261 0.0481 1.1 -0.872 0.757 0.249 0.604 0.418 0.0923 1.66 -1.37 0.79 0.0828 1.082 0.254 0.0494 1.05 PRS_PLINK_1.99526231496888e.08 TRUE 401.22 Hypertensive chronic kidney disease Both 54 280 8 circulatory system red 280, 54 44, 5 97, 21 44, 9 68, 14 -0.0219 0.128 0.864 0.063 0.978 0.717 1.22 0.552 0.523 0.291 0.536 1.74 0.659 5.27 0.712 0.615 0.247 0.608 2.04 0.627 7.52 0.506 0.533 0.342 0.466 1.66 0.604 5.18 PRS_PLINK_1.99526231496888e.08 FALSE 401.3 Other hypertensive complications Both 78 395 8 circulatory system red 395, 78 57, 8 135, 33 64, 12 97, 17 -0.104 0.13 0.426 0.371 0.901 0.664 1.13 0.691 0.446 0.121 0.917 2 0.869 5.06 0.185 0.493 0.708 0.15 1.2 0.459 3.26 0.17 0.453 0.708 0.15 1.19 0.491 3.04 PRS_PLINK_1.99526231496888e.08 FALSE 411 Ischemic Heart Disease Both 186 671 8 circulatory system red 671, 186 103, 24 226, 72 110, 22 164, 47 -0.0679 0.102 0.504 0.298 0.934 0.754 1.13 0.249 0.296 0.4 0.398 1.28 0.727 2.32 -0.227 0.354 0.521 0.284 0.797 0.397 1.59 0.142 0.304 0.641 0.193 1.15 0.641 2.11 PRS_PLINK_1.99526231496888e.08 FALSE 411.1 Unstable angina (intermediate coronary syndrome) Both 29 96 8 circulatory system red 96, 29 20, 7 29, 9 19, 6 24, 6 -0.0262 0.328 0.937 0.028 0.974 0.518 1.86 -0.321 0.646 0.619 0.208 0.725 0.207 2.47 -0.203 0.785 0.796 0.099 0.816 0.178 3.64 -0.285 0.725 0.695 0.158 0.752 0.18 3.11 PRS_PLINK_1.99526231496888e.08 TRUE 411.2 Myocardial infarction Both 60 340 8 circulatory system red 340, 60 53, 11 115, 23 57, 7 83, 12 -0.292 0.185 0.113 0.947 0.746 0.513 1.07 -0.0813 0.422 0.847 0.072 0.922 0.411 2.16 -0.712 0.543 0.19 0.721 0.491 0.16 1.4 -0.377 0.465 0.417 0.38 0.686 0.274 1.71 PRS_PLINK_1.99526231496888e.08 FALSE 411.3 Angina pectoris Both 65 268 8 circulatory system red 268, 65 45, 10 84, 24 51, 7 66, 18 -0.0938 0.16 0.558 0.253 0.91 0.629 1.2 -0.0111 0.447 0.98 0.009 0.989 0.42 2.41 -0.676 0.588 0.25 0.601 0.509 0.155 1.56 0.168 0.444 0.706 0.151 1.18 0.507 2.87 PRS_PLINK_1.99526231496888e.08 FALSE 411.4 Coronary atherosclerosis Both 152 553 8 circulatory system red 553, 152 95, 27 182, 56 91, 18 138, 36 -0.0816 0.115 0.48 0.319 0.922 0.72 1.14 -0.0595 0.3 0.843 0.074 0.942 0.527 1.7 -0.527 0.372 0.156 0.806 0.59 0.28 1.21 -0.205 0.312 0.511 0.292 0.814 0.442 1.51 PRS_PLINK_1.99526231496888e.08 FALSE 411.41 Aneurysm and dissection of heart Both 0 26 8 circulatory system red 26, 0 4 10 2 7 PRS_PLINK_1.99526231496888e.08 TRUE 411.8 Other chronic ischemic heart disease, unspecified Both 113 463 8 circulatory system red 463, 113 72, 14 160, 45 71, 9 115, 31 -0.0727 0.129 0.573 0.242 0.93 0.705 1.18 0.178 0.377 0.636 0.196 1.2 0.582 2.55 -0.729 0.506 0.149 0.825 0.482 0.172 1.28 0.21 0.377 0.577 0.239 1.23 0.599 2.63 PRS_PLINK_1.99526231496888e.08 FALSE 411.9 Other acute and subacute forms of ischemic heart disease Both 6 52 8 circulatory system red 52, 6 6, 1 16, 2 10, 1 13, 2 0.145 0.607 0.812 0.091 1.16 0.324 4.77 -0.45 1.63 0.782 0.107 0.638 0.0199 37.1 -0.468 1.62 0.772 0.112 0.626 0.00169 35.6 -0.354 1.49 0.812 0.09 0.702 0.019 31 PRS_PLINK_1.99526231496888e.08 TRUE 414 Other forms of chronic heart disease Both 90 393 8 circulatory system red 393, 90 54, 13 130, 27 67, 12 96, 29 0.0356 0.116 0.759 0.12 1.04 0.808 1.28 -0.339 0.404 0.402 0.396 0.712 0.326 1.6 -0.669 0.477 0.161 0.793 0.512 0.198 1.28 0.122 0.38 0.748 0.126 1.13 0.547 2.41 PRS_PLINK_1.99526231496888e.08 FALSE 414.2 ASCVD Both 26 110 8 circulatory system red 110, 26 18, 4 29, 6 25, 4 28, 9 0.0569 0.225 0.8 0.097 1.06 0.614 1.54 -0.352 0.802 0.66 0.18 0.703 0.143 3.47 -0.757 0.827 0.36 0.443 0.469 0.0884 2.25 0.283 0.695 0.684 0.165 1.33 0.366 5.28 PRS_PLINK_1.99526231496888e.08 TRUE 415 Pulmonary heart disease Both 81 603 8 circulatory system red 603, 81 85, 11 206, 28 95, 13 151, 20 0.21 0.104 0.0445 1.352 1.23 1.01 1.51 -0.0412 0.376 0.913 0.04 0.96 0.463 2.1 -0.00747 0.431 0.986 0.006 0.993 0.421 2.38 0.0239 0.389 0.951 0.022 1.02 0.475 2.3 PRS_PLINK_1.99526231496888e.08 FALSE 415.1 Acute pulmonary heart disease Both 55 359 8 circulatory system red 359, 55 54, 7 121, 21 57, 8 90, 12 0.19 0.115 0.0981 1.008 1.21 0.966 1.5 0.285 0.457 0.533 0.273 1.33 0.552 3.49 0.048 0.535 0.929 0.032 1.05 0.362 3.11 -0.0766 0.498 0.878 0.057 0.926 0.342 2.6 PRS_PLINK_1.99526231496888e.08 FALSE 415.11 Pulmonary embolism and infarction, acute Both 54 354 8 circulatory system red 354, 54 52, 7 120, 21 57, 7 88, 12 0.179 0.116 0.121 0.916 1.2 0.953 1.48 0.203 0.457 0.656 0.183 1.23 0.509 3.21 -0.11 0.547 0.841 0.075 0.896 0.299 2.7 -0.091 0.502 0.856 0.067 0.913 0.335 2.58 PRS_PLINK_1.99526231496888e.08 FALSE 415.2 Chronic pulmonary heart disease Both 41 312 8 circulatory system red 312, 41 39, 4 114, 16 43, 6 77, 11 0.354 0.155 0.0224 1.649 1.42 1.08 1.98 0.225 0.585 0.7 0.155 1.25 0.409 4.57 0.103 0.648 0.874 0.059 1.11 0.301 4.35 0.427 0.622 0.492 0.308 1.53 0.46 6 PRS_PLINK_1.99526231496888e.08 TRUE 415.21 Primary pulmonary hypertension Both 20 127 8 circulatory system red 127, 20 19, 4 34, 5 30, 4 31, 5 0.00775 0.299 0.979 0.009 1.01 0.564 1.87 -0.602 0.819 0.462 0.335 0.548 0.105 2.86 -0.423 0.773 0.585 0.233 0.655 0.14 2.99 -0.813 0.821 0.322 0.492 0.443 0.0811 2.19 PRS_PLINK_1.99526231496888e.08 TRUE 416 Cardiomegaly Both 38 216 8 circulatory system red 216, 38 38, 9 69, 11 37, 3 54, 12 -0.0529 0.238 0.824 0.084 0.948 0.594 1.53 -0.512 0.5 0.306 0.515 0.599 0.225 1.6 -0.879 0.673 0.192 0.718 0.415 0.0965 1.48 -0.085 0.496 0.864 0.064 0.919 0.348 2.45 PRS_PLINK_1.99526231496888e.08 TRUE 418 Nonspecific chest pain Both 614 649 8 circulatory system red 649, 614 99, 85 208, 209 116, 92 161, 159 0.0048 0.0581 0.934 0.03 1 0.896 1.12 0.0911 0.188 0.629 0.202 1.1 0.76 1.58 -0.135 0.221 0.542 0.266 0.874 0.569 1.34 0.0814 0.197 0.679 0.168 1.08 0.74 1.59 PRS_PLINK_1.99526231496888e.08 FALSE 418.1 Precordial pain Both 79 159 8 circulatory system red 159, 79 29, 12 52, 28 26, 15 40, 13 -0.265 0.195 0.175 0.757 0.767 0.525 1.12 0.25 0.453 0.581 0.236 1.28 0.547 3.11 0.171 0.574 0.766 0.116 1.19 0.403 3.56 -0.295 0.553 0.594 0.226 0.745 0.256 2.17 PRS_PLINK_1.99526231496888e.08 FALSE 420 Carditis Both 51 278 8 circulatory system red 278, 51 40, 4 107, 11 30, 13 70, 18 0.258 0.167 0.122 0.914 1.29 0.936 1.8 -0.242 0.587 0.68 0.168 0.785 0.254 2.78 1.74 0.671 0.00964 2.016 5.68 1.65 24.4 0.795 0.58 0.17 0.769 2.21 0.743 7.91 PRS_PLINK_1.99526231496888e.08 FALSE 420.1 Myocarditis Both 2 19 8 circulatory system red 19, 2 2, 0 5, 0 4, 0 5, 2 0.962 0.86 0.263 0.58 2.62 0.665 73.6 0.474 41.9 0.991 0.004 1.61 1.66 26.6 PRS_PLINK_1.99526231496888e.08 TRUE 420.2 Pericarditis Both 27 147 8 circulatory system red 147, 27 20, 3 58, 5 15, 6 37, 10 0.162 0.275 0.557 0.254 1.18 0.688 2.05 -1.24 0.836 0.139 0.857 0.29 0.0495 1.54 0.638 0.994 0.521 0.283 1.89 0.267 18.2 0.608 0.761 0.425 0.372 1.84 0.458 9.41 PRS_PLINK_1.99526231496888e.08 TRUE 420.21 Acute pericarditis Both 7 34 8 circulatory system red 34, 7 7, 2 8, 0 8, 3 9, 1 -0.324 0.612 0.596 0.225 0.723 0.219 2.38 -1.33 1.89 0.483 0.316 0.265 0.000142 6.17 0.485 1.59 0.761 0.119 1.62 0.0815 107 -1.2 1.91 0.53 0.275 0.301 8.37e-08 7.71 PRS_PLINK_1.99526231496888e.08 TRUE 420.22 Chronic pericarditis Both 5 19 8 circulatory system red 19, 5 4, 2 6, 1 4, 1 4, 0 -1.31 0.855 0.126 0.899 0.27 8e-04 1.11 -1.5 2 0.452 0.345 0.222 0.000232 7.52 -1.97 2.14 0.358 0.446 0.14 4.23e-05 2.64 -1.87 2.34 0.425 0.371 0.155 0.00125 3.52 PRS_PLINK_1.99526231496888e.08 TRUE 420.3 Endocarditis Both 25 133 8 circulatory system red 133, 25 21, 2 53, 5 13, 6 33, 8 0.18 0.226 0.425 0.372 1.2 0.725 1.78 -0.332 0.754 0.66 0.18 0.718 0.165 3.95 2.6 1.31 0.0476 1.322 13.5 1.48 1560 0.641 0.762 0.401 0.397 1.9 0.46 10.7 PRS_PLINK_1.99526231496888e.08 TRUE 425 Cardiomyopathy Both 52 325 8 circulatory system red 325, 52 43, 5 83, 14 80, 12 79, 17 0.254 0.195 0.192 0.716 1.29 0.881 1.91 0.0726 0.534 0.892 0.05 1.08 0.389 3.32 0.454 0.568 0.424 0.373 1.58 0.531 5.43 0.547 0.508 0.282 0.549 1.73 0.665 5.19 PRS_PLINK_1.99526231496888e.08 FALSE 425.1 Primary/intrinsic cardiomyopathies Both 50 303 8 circulatory system red 303, 50 41, 5 76, 14 75, 11 75, 16 0.236 0.202 0.243 0.615 1.27 0.853 1.91 0.142 0.544 0.794 0.1 1.15 0.409 3.62 0.254 0.577 0.659 0.181 1.29 0.425 4.48 0.522 0.518 0.314 0.504 1.69 0.637 5.13 PRS_PLINK_1.99526231496888e.08 TRUE 425.11 Hypertrophic obstructive cardiomyopathy Both 5 39 8 circulatory system red 39, 5 7, 0 11, 1 9, 1 9, 3 1.13 0.649 0.0814 1.089 3.1 0.963 13.5 -0.0019 1.89 0.999 0 0.998 0.00242 466 0.13 2.88 0.964 0.016 1.14 0.000392 2710 2.09 1.59 0.188 0.727 8.08 0.678 53100 PRS_PLINK_1.99526231496888e.08 TRUE 425.12 Other hypertrophic cardiomyopathy Both 4 34 8 circulatory system red 34, 4 6, 0 9, 0 7, 1 9, 3 1.29 0.96 0.179 0.747 3.63 0.662 99.9 0.0338 1.88 0.986 0.006 1.03 0.0498 26.9 0.64 1.82 0.725 0.14 1.9 0.0469 235 PRS_PLINK_1.99526231496888e.08 TRUE 425.2 Secondary/extrinsic cardiomyopathies Both 10 66 8 circulatory system red 66, 10 4, 1 17, 3 15, 3 17, 3 0.141 0.261 0.589 0.23 1.15 0.592 2.25 -0.403 1.49 0.787 0.104 0.669 0.0297 21.6 -1.31 1.9 0.491 0.309 0.27 0.000273 8.84 -1.59 1.61 0.323 0.49 0.205 0.00262 4.71 PRS_PLINK_1.99526231496888e.08 TRUE 425.8 Other cardiomyopathy Both 4 12 8 circulatory system red 12, 4 1, 0 3, 1 3, 1 3, 1 0.0879 0.778 0.91 0.041 1.09 0.062 4.69 0.0688 6440 1 0 1.07 0.445 1.7 0.0579 2540 1 0 1.06 0.758 1.55 -0.31 1620 1 0 0.734 0.074 2.88 PRS_PLINK_1.99526231496888e.08 TRUE 426 Cardiac conduction disorders Both 389 584 8 circulatory system red 584, 389 79, 44 199, 150 95, 50 144, 105 0.0067 0.0744 0.928 0.032 1.01 0.866 1.16 0.192 0.24 0.424 0.372 1.21 0.761 1.94 0.00269 0.293 0.993 0.003 1 0.568 1.78 0.224 0.256 0.381 0.419 1.25 0.762 2.07 PRS_PLINK_1.99526231496888e.08 FALSE 426.2 Atrioventricular [AV] block Both 34 134 8 circulatory system red 134, 34 13, 4 49, 14 17, 5 34, 11 0.333 0.198 0.0936 1.029 1.39 1 2.2 -0.15 0.822 0.855 0.068 0.861 0.182 4.6 0.13 0.994 0.896 0.048 1.14 0.15 7.92 -0.0794 0.738 0.914 0.039 0.924 0.237 3.93 PRS_PLINK_1.99526231496888e.08 TRUE 426.21 First degree AV block Both 25 85 8 circulatory system red 85, 25 9, 4 28, 12 14, 4 21, 5 -0.0533 0.324 0.869 0.061 0.948 0.509 1.78 0.097 0.885 0.913 0.04 1.1 0.217 5.81 -0.0839 1.08 0.938 0.028 0.92 0.102 6.56 -0.802 0.937 0.392 0.407 0.448 0.071 2.39 PRS_PLINK_1.99526231496888e.08 TRUE 426.22 Mobitz II AV block Both 0 6 8 circulatory system red 6, 0 1 1 1 2 PRS_PLINK_1.99526231496888e.08 TRUE 426.23 Second degree AV block Both 6 23 8 circulatory system red 23, 6 3, 1 8, 1 3, 1 6, 3 0.38 0.396 0.337 0.473 1.46 0.797 8.94 -0.0353 2.58 0.989 0.005 0.965 0.00413 2270 0.0439 1710 1 0 1.04 0.841 1.09 0.139 3.08 0.964 0.016 1.15 0.00149 5430000 PRS_PLINK_1.99526231496888e.08 TRUE 426.24 Atrioventricular block, complete Both 3 51 8 circulatory system red 51, 3 8, 0 14, 0 11, 0 13, 3 1.13 0.869 0.194 0.713 3.1 0.533 82.3 0.401 1.97 0.839 0.076 1.49 0.032 259 PRS_PLINK_1.99526231496888e.08 TRUE 426.25 Other heart block Both 3 11 8 circulatory system red 11, 3 2, 0 3, 0 2, 0 3, 3 0.893 1.4 0.525 0.28 2.44 0.358 14800 1.42 225 0.995 0.002 4.14 0.0338 17.2 PRS_PLINK_1.99526231496888e.08 TRUE 426.3 Bundle branch block Both 45 175 8 circulatory system red 175, 45 24, 4 63, 16 23, 8 44, 14 0.172 0.131 0.188 0.725 1.19 0.91 1.5 -0.134 0.657 0.838 0.077 0.874 0.246 3.44 0.859 0.767 0.263 0.581 2.36 0.556 11.8 0.101 0.649 0.876 0.057 1.11 0.323 4.13 PRS_PLINK_1.99526231496888e.08 TRUE 426.31 Right bundle branch block Both 32 123 8 circulatory system red 123, 32 15, 4 31, 5 30, 3 31, 18 0.523 0.233 0.025 1.601 1.69 1.14 2.9 -1.08 0.817 0.186 0.732 0.339 0.058 1.63 -1.28 0.953 0.181 0.743 0.279 0.022 1.81 0.248 0.669 0.711 0.148 1.28 0.369 4.85 PRS_PLINK_1.99526231496888e.08 TRUE 426.32 Left bundle branch block Both 16 78 8 circulatory system red 78, 16 11, 1 27, 10 10, 2 20, 2 0.00901 0.231 0.969 0.014 1.01 0.359 1.39 0.689 1.03 0.505 0.297 1.99 0.312 21.2 0.168 1.65 0.919 0.037 1.18 0.000618 127 -0.152 1.3 0.907 0.042 0.859 0.0483 56.8 PRS_PLINK_1.99526231496888e.08 TRUE 426.4 Anomalous atrioventricular excitation Both 2 13 8 circulatory system red 13, 2 3, 0 3, 2 3, 0 3, 0 0.0157 1.74 0.993 0.003 1.02 0.00459 396 1.29 5.79 0.823 0.084 3.64 4.96 5.05 PRS_PLINK_1.99526231496888e.08 TRUE 426.7 Abnormal electrocardiogram [ECG] [EKG] Both 362 584 8 circulatory system red 584, 362 85, 43 193, 139 96, 49 144, 93 -0.0137 0.0807 0.865 0.063 0.986 0.836 1.15 0.247 0.243 0.309 0.51 1.28 0.801 2.06 0.153 0.298 0.609 0.215 1.16 0.653 2.09 0.241 0.259 0.353 0.453 1.27 0.77 2.12 PRS_PLINK_1.99526231496888e.08 FALSE 426.8 Other cardiac conduction disorders Both 25 119 8 circulatory system red 119, 25 16, 5 35, 8 24, 2 30, 4 -0.644 0.319 0.0431 1.366 0.525 0.272 1 -0.632 0.707 0.371 0.43 0.532 0.139 2.09 -1.93 1.05 0.0656 1.183 0.145 0.008 0.966 -0.638 0.855 0.456 0.341 0.528 0.0885 2.93 PRS_PLINK_1.99526231496888e.08 TRUE 426.9 Cardiac pacemaker/device in situ Both 24 126 8 circulatory system red 126, 24 17, 2 32, 7 30, 5 32, 8 0.102 0.311 0.744 0.128 1.11 0.602 2.09 -0.0316 0.87 0.971 0.013 0.969 0.178 6.17 0.134 0.945 0.887 0.052 1.14 0.183 9.89 0.053 0.892 0.953 0.021 1.05 0.161 6.95 PRS_PLINK_1.99526231496888e.08 TRUE 426.91 Cardiac pacemaker in situ Both 17 83 8 circulatory system red 83, 17 8, 1 24, 4 17, 3 21, 8 0.262 0.381 0.493 0.308 1.3 0.621 2.85 -0.59 1.12 0.599 0.223 0.554 0.0624 5.73 0.3 1.22 0.806 0.093 1.35 0.147 31.4 0.146 1.19 0.902 0.045 1.16 0.147 24.6 PRS_PLINK_1.99526231496888e.08 TRUE 426.92 Cardiac defibrillator in situ Both 13 61 8 circulatory system red 61, 13 6, 1 15, 4 15, 3 15, 4 0.0309 0.429 0.943 0.026 1.03 0.449 2.46 -0.774 1.4 0.582 0.235 0.461 0.0214 6.33 0.437 1.48 0.767 0.115 1.55 0.112 63100 0.482 1.46 0.742 0.13 1.62 0.114 32 PRS_PLINK_1.99526231496888e.08 TRUE 427 Cardiac dysrhythmias Both 603 587 8 circulatory system red 587, 603 80, 68 200, 219 93, 87 147, 170 0.0327 0.0591 0.58 0.237 1.03 0.922 1.16 0.148 0.204 0.466 0.331 1.16 0.781 1.72 0.094 0.236 0.691 0.161 1.1 0.696 1.74 0.206 0.214 0.336 0.474 1.23 0.812 1.86 PRS_PLINK_1.99526231496888e.08 FALSE 427.1 Paroxysmal tachycardia, unspecified Both 82 336 8 circulatory system red 336, 82 44, 6 87, 25 80, 17 84, 27 0.0632 0.12 0.598 0.223 1.07 0.816 1.31 0.238 0.502 0.636 0.196 1.27 0.484 3.65 0.133 0.505 0.792 0.101 1.14 0.432 3.3 0.32 0.498 0.521 0.284 1.38 0.537 3.9 PRS_PLINK_1.99526231496888e.08 FALSE 427.11 Paroxysmal supraventricular tachycardia Both 59 266 8 circulatory system red 266, 59 36, 6 66, 18 66, 12 67, 18 0.0454 0.128 0.724 0.14 1.05 0.778 1.3 0.163 0.537 0.761 0.119 1.18 0.418 3.58 -0.00986 0.541 0.985 0.006 0.99 0.343 3.05 0.0569 0.546 0.917 0.038 1.06 0.368 3.24 PRS_PLINK_1.99526231496888e.08 FALSE 427.12 Paroxysmal ventricular tachycardia Both 34 111 8 circulatory system red 111, 34 12, 1 30, 12 25, 9 28, 10 0.255 0.293 0.384 0.415 1.29 0.738 2.31 0.572 0.981 0.56 0.252 1.77 0.306 17.7 0.659 1.09 0.544 0.265 1.93 0.273 33.1 0.87 1.06 0.41 0.387 2.39 0.368 31.1 PRS_PLINK_1.99526231496888e.08 TRUE 427.2 Atrial fibrillation and flutter Both 86 279 8 circulatory system red 279, 86 35, 5 74, 30 65, 16 70, 28 0.318 0.152 0.0368 1.434 1.37 1.04 1.88 0.57 0.628 0.364 0.439 1.77 0.548 6.67 0.201 0.599 0.738 0.132 1.22 0.399 4.2 0.587 0.535 0.272 0.565 1.8 0.665 5.57 PRS_PLINK_1.99526231496888e.08 FALSE 427.21 Atrial fibrillation Both 84 265 8 circulatory system red 265, 84 31, 4 71, 30 62, 14 65, 29 0.367 0.159 0.0207 1.684 1.44 1.09 2.02 0.956 0.706 0.176 0.756 2.6 0.714 12.2 0.377 0.721 0.601 0.221 1.46 0.381 6.65 0.866 0.571 0.13 0.887 2.38 0.834 8.22 PRS_PLINK_1.99526231496888e.08 FALSE 427.22 Atrial flutter Both 38 105 8 circulatory system red 105, 38 9, 2 32, 14 20, 7 26, 12 0.265 0.283 0.348 0.458 1.3 0.76 2.28 -0.0848 0.999 0.932 0.03 0.919 0.132 8.42 0.125 1.01 0.902 0.045 1.13 0.179 9.29 0.429 0.944 0.649 0.188 1.54 0.269 10.3 PRS_PLINK_1.99526231496888e.08 TRUE 427.3 Other specified cardiac dysrhythmias Both 288 586 8 circulatory system red 586, 288 80, 36 200, 104 92, 41 147, 82 0.0299 0.0752 0.691 0.161 1.03 0.886 1.19 0.0903 0.252 0.72 0.143 1.09 0.674 1.8 0.00628 0.292 0.983 0.008 1.01 0.572 1.78 0.183 0.263 0.485 0.314 1.2 0.724 2.01 PRS_PLINK_1.99526231496888e.08 FALSE 427.4 Cardiac arrest and ventricular fibrillation Both 12 66 8 circulatory system red 66, 12 9, 3 22, 4 10, 2 17, 3 0.189 0.435 0.664 0.178 1.21 0.522 2.99 -1.03 0.941 0.274 0.562 0.357 0.0473 1.93 -0.219 1.17 0.851 0.07 0.803 0.0264 10.2 -1.16 1.03 0.262 0.582 0.314 0.0332 2.06 PRS_PLINK_1.99526231496888e.08 TRUE 427.41 Ventricular fibrillation and flutter Both 5 26 8 circulatory system red 26, 5 5, 2 6, 0 5, 1 7, 2 -0.537 0.755 0.477 0.322 0.584 0.0609 2.46 -0.81 2.17 0.709 0.149 0.445 0.000102 16.4 -0.0496 217 1 0 0.952 0.501 1.34 -0.212 1.37 0.877 0.057 0.809 0.0762 8.86 PRS_PLINK_1.99526231496888e.08 TRUE 427.42 Cardiac arrest Both 10 48 8 circulatory system red 48, 10 7, 0 13, 4 11, 4 11, 2 0.475 0.517 0.358 0.446 1.61 0.608 4.78 -1.08 2.08 0.602 0.22 0.338 0.000271 67.8 2.19 1.77 0.215 0.668 8.95 0.438 94100 1.34 2.1 0.523 0.281 3.81 0.122 43200 PRS_PLINK_1.99526231496888e.08 TRUE 427.5 Arrhythmia (cardiac) NOS Both 223 581 8 circulatory system red 581, 223 85, 31 193, 79 94, 27 144, 65 0.0663 0.0749 0.376 0.425 1.07 0.919 1.23 -0.0471 0.269 0.861 0.065 0.954 0.568 1.62 -0.152 0.331 0.647 0.189 0.859 0.449 1.64 0.141 0.285 0.621 0.207 1.15 0.663 2.02 PRS_PLINK_1.99526231496888e.08 FALSE 427.6 Premature beats Both 95 265 8 circulatory system red 265, 95 34, 8 67, 30 64, 20 66, 30 0.0906 0.129 0.483 0.316 1.09 0.826 1.37 0.129 0.513 0.801 0.096 1.14 0.43 3.16 0.111 0.499 0.824 0.084 1.12 0.438 3.01 0.563 0.455 0.216 0.665 1.76 0.754 4.41 PRS_PLINK_1.99526231496888e.08 FALSE 427.61 Supraventricular premature beats Both 20 72 8 circulatory system red 72, 20 9, 0 19, 7 17, 8 18, 4 0.291 0.405 0.473 0.326 1.34 0.614 3.12 1.48 1.57 0.344 0.464 4.41 0.254 1070000 1.35 1.61 0.402 0.396 3.84 0.279 499 2.06 1.96 0.292 0.535 7.87 0.222 19700 PRS_PLINK_1.99526231496888e.08 TRUE 427.7 Tachycardia NOS Both 250 585 8 circulatory system red 585, 250 86, 27 193, 88 96, 40 144, 65 -0.0222 0.0798 0.781 0.107 0.978 0.829 1.13 0.364 0.271 0.178 0.749 1.44 0.857 2.47 0.295 0.299 0.324 0.49 1.34 0.754 2.42 0.27 0.279 0.334 0.476 1.31 0.765 2.28 PRS_PLINK_1.99526231496888e.08 FALSE 427.8 Sinoatrial node dysfunction (Bradycardia) Both 26 85 8 circulatory system red 85, 26 10, 2 26, 9 16, 6 21, 9 0.389 0.322 0.226 0.645 1.48 0.804 2.83 0.543 0.988 0.583 0.235 1.72 0.282 13.8 -0.474 1.08 0.659 0.181 0.623 0.0779 5.27 -1.09 1.15 0.342 0.466 0.336 0.0304 2.8 PRS_PLINK_1.99526231496888e.08 TRUE 427.9 Palpitations Both 293 571 8 circulatory system red 571, 293 82, 30 191, 110 92, 33 141, 90 0.104 0.0705 0.14 0.853 1.11 0.968 1.27 0.395 0.26 0.129 0.889 1.48 0.903 2.48 0.0916 0.33 0.781 0.107 1.1 0.579 2.09 0.529 0.272 0.0517 1.286 1.7 1.01 2.9 PRS_PLINK_1.99526231496888e.08 FALSE 428 Congestive heart failure; nonhypertensive Both 84 373 8 circulatory system red 373, 84 59, 19 123, 26 62, 9 93, 26 0.0609 0.125 0.626 0.204 1.06 0.798 1.32 -0.481 0.365 0.187 0.729 0.618 0.304 1.26 -0.735 0.461 0.111 0.956 0.479 0.188 1.15 -0.101 0.362 0.781 0.108 0.904 0.45 1.84 PRS_PLINK_1.99526231496888e.08 FALSE 428.1 Congestive heart failure (CHF) NOS Both 71 341 8 circulatory system red 341, 71 55, 13 119, 25 48, 8 85, 22 0.0956 0.123 0.438 0.358 1.1 0.826 1.36 -0.338 0.399 0.397 0.402 0.713 0.329 1.57 -0.396 0.493 0.422 0.375 0.673 0.247 1.74 0.00287 0.393 0.994 0.003 1 0.468 2.2 PRS_PLINK_1.99526231496888e.08 FALSE 428.2 Heart failure NOS Both 61 304 8 circulatory system red 304, 61 45, 11 103, 19 49, 8 75, 19 0.13 0.14 0.354 0.451 1.14 0.817 1.44 -0.448 0.471 0.341 0.468 0.639 0.256 1.62 -0.425 0.535 0.428 0.369 0.654 0.225 1.84 0.0688 0.457 0.88 0.055 1.07 0.446 2.67 PRS_PLINK_1.99526231496888e.08 FALSE 428.3 Heart failure with reduced EF [Systolic or combined heart failure] Both 27 162 8 circulatory system red 162, 27 25, 5 54, 10 26, 3 40, 8 0.113 0.17 0.505 0.297 1.12 0.71 1.46 -0.418 0.618 0.499 0.302 0.658 0.198 2.28 -0.646 0.764 0.398 0.401 0.524 0.103 2.23 -0.00663 0.615 0.991 0.004 0.993 0.305 3.43 PRS_PLINK_1.99526231496888e.08 TRUE 428.4 Heart failure with preserved EF [Diastolic heart failure] Both 38 161 8 circulatory system red 161, 38 23, 7 55, 11 27, 6 38, 10 0.0635 0.247 0.797 0.099 1.07 0.66 1.74 -0.35 0.625 0.575 0.24 0.705 0.212 2.39 -0.218 0.666 0.743 0.129 0.804 0.22 2.84 0.109 0.659 0.868 0.061 1.12 0.317 4.15 PRS_PLINK_1.99526231496888e.08 TRUE 429 Ill-defined descriptions and complications of heart disease Both 503 748 8 circulatory system red 748, 503 111, 56 247, 183 126, 70 185, 139 -0.0154 0.0606 0.799 0.098 0.985 0.872 1.1 0.334 0.2 0.0947 1.024 1.4 0.949 2.07 0.136 0.233 0.557 0.254 1.15 0.73 1.81 0.3 0.211 0.154 0.812 1.35 0.897 2.04 PRS_PLINK_1.99526231496888e.08 FALSE 429.1 Heart transplant/surgery Both 30 136 8 circulatory system red 136, 30 19, 2 36, 11 30, 10 34, 6 0.165 0.296 0.578 0.238 1.18 0.661 2.15 0.653 0.768 0.395 0.403 1.92 0.462 10.9 1.02 0.815 0.212 0.674 2.77 0.622 16.6 0.388 0.837 0.643 0.192 1.47 0.298 9.5 PRS_PLINK_1.99526231496888e.08 TRUE 429.2 Abnormal function study of cardiovascular system Both 226 653 8 circulatory system red 653, 226 101, 29 218, 89 107, 29 161, 54 -0.136 0.0986 0.169 0.772 0.873 0.713 1.05 0.26 0.264 0.323 0.491 1.3 0.782 2.19 -0.0654 0.319 0.838 0.077 0.937 0.501 1.75 0.151 0.281 0.59 0.229 1.16 0.675 2.03 PRS_PLINK_1.99526231496888e.08 FALSE 429.3 Symptoms involving cardiovascular system Both 425 748 8 circulatory system red 748, 425 111, 44 247, 151 126, 60 185, 120 0.0015 0.0619 0.981 0.008 1 0.884 1.13 0.408 0.214 0.0567 1.246 1.5 0.996 2.3 0.212 0.246 0.39 0.409 1.24 0.767 2 0.401 0.223 0.0727 1.139 1.49 0.97 2.32 PRS_PLINK_1.99526231496888e.08 FALSE 429.9 Cardiac complications, not elsewhere classified Both 12 88 8 circulatory system red 88, 12 10, 1 24, 6 20, 3 22, 0 -0.604 0.495 0.222 0.653 0.547 0.186 1.45 0.207 1.13 0.855 0.068 1.23 0.15 14 -0.178 1.14 0.876 0.058 0.837 0.0799 10.2 -0.631 1.33 0.635 0.197 0.532 0.00183 36 PRS_PLINK_1.99526231496888e.08 TRUE 430 Intracranial hemorrhage Both 24 164 8 circulatory system red 164, 24 21, 1 45, 4 37, 8 41, 8 0.343 0.225 0.128 0.892 1.41 0.908 2.19 0.24 0.934 0.797 0.099 1.27 0.2 12.4 1.18 0.902 0.193 0.715 3.24 0.644 32.9 1.23 0.906 0.175 0.756 3.41 0.65 35.3 PRS_PLINK_1.99526231496888e.08 TRUE 430.1 Subarachnoid hemorrhage Both 10 64 8 circulatory system red 64, 10 9, 2 21, 3 11, 2 16, 2 0.056 0.302 0.853 0.069 1.06 0.525 1.79 -1.42 1.27 0.264 0.579 0.242 0.00833 2.44 0.727 1.17 0.535 0.272 2.07 0.246 24.5 -1.29 1.37 0.347 0.459 0.275 0.0017 3.17 PRS_PLINK_1.99526231496888e.08 TRUE 430.2 Intracerebral hemorrhage Both 11 77 8 circulatory system red 77, 11 11, 2 24, 2 13, 3 19, 3 0.337 0.42 0.422 0.375 1.4 0.629 3.64 -1.52 1.35 0.26 0.584 0.219 0.00205 2.86 1.13 1.27 0.374 0.428 3.09 0.307 58.8 0.249 1.15 0.829 0.082 1.28 0.142 15.3 PRS_PLINK_1.99526231496888e.08 TRUE 430.3 Subdural hemorrhage Both 4 48 8 circulatory system red 48, 4 6, 1 14, 0 10, 0 12, 2 0.408 0.625 0.514 0.289 1.5 0.424 13 -0.46 1.54 0.764 0.117 0.631 0.0139 12.8 -0.978 2.44 0.689 0.162 0.376 0.000172 18.1 0.352 1.52 0.817 0.088 1.42 0.118 78.1 PRS_PLINK_1.99526231496888e.08 TRUE 433 Cerebrovascular disease Both 125 718 8 circulatory system red 718, 125 105, 18 248, 43 106, 13 180, 43 0.118 0.0958 0.219 0.66 1.13 0.92 1.34 -0.1 0.315 0.751 0.124 0.905 0.494 1.7 -0.26 0.388 0.502 0.3 0.771 0.352 1.65 0.237 0.31 0.443 0.353 1.27 0.7 2.37 PRS_PLINK_1.99526231496888e.08 FALSE 433.1 Occlusion and stenosis of precerebral arteries Both 43 219 8 circulatory system red 219, 43 36, 14 73, 11 36, 5 55, 10 -0.214 0.227 0.346 0.461 0.808 0.518 1.26 -0.971 0.464 0.0362 1.441 0.379 0.15 0.919 -0.8 0.574 0.163 0.787 0.449 0.136 1.3 -0.795 0.482 0.0989 1.005 0.451 0.173 1.13 PRS_PLINK_1.99526231496888e.08 TRUE 433.11 Occlusion of cerebral arteries, with cerebral infarction Both 5 42 8 circulatory system red 42, 5 6, 2 13, 2 7, 0 11, 1 -0.185 0.545 0.734 0.134 0.831 0.27 2.59 2.24 2.06 0.277 0.558 9.4 0.383 3e+08 -0.152 1.64 0.926 0.033 0.859 0.656 0.95 -1.02 1.35 0.451 0.346 0.361 0.0149 3.4 PRS_PLINK_1.99526231496888e.08 TRUE 433.12 Cerebral atherosclerosis Both 2 12 8 circulatory system red 12, 2 2, 0 3, 2 3, 0 3, 0 -0.815 1.46 0.577 0.239 0.443 0.00503 6.19 0.0968 12200000 1 0 1.1 0.0608 128 PRS_PLINK_1.99526231496888e.08 TRUE 433.2 Occlusion of cerebral arteries Both 60 394 8 circulatory system red 394, 60 59, 5 133, 20 63, 8 97, 23 0.243 0.144 0.0925 1.034 1.27 0.946 1.66 0.324 0.505 0.522 0.283 1.38 0.532 4.14 0.537 0.566 0.342 0.465 1.71 0.557 5.77 0.91 0.507 0.0726 1.139 2.48 0.963 7.54 PRS_PLINK_1.99526231496888e.08 FALSE 433.21 Cerebral artery occlusion, with cerebral infarction Both 58 378 8 circulatory system red 378, 58 55, 5 132, 19 55, 7 95, 23 0.237 0.145 0.101 0.997 1.27 0.941 1.66 0.19 0.509 0.709 0.149 1.21 0.461 3.65 0.421 0.579 0.467 0.33 1.52 0.475 5.28 0.812 0.504 0.107 0.971 2.25 0.878 6.72 PRS_PLINK_1.99526231496888e.08 FALSE 433.3 Cerebral ischemia Both 66 398 8 circulatory system red 398, 66 53, 9 143, 25 55, 5 99, 23 0.124 0.135 0.358 0.446 1.13 0.841 1.44 -0.0601 0.421 0.887 0.052 0.942 0.423 2.24 -0.713 0.57 0.211 0.675 0.49 0.145 1.5 0.0683 0.434 0.875 0.058 1.07 0.464 2.6 PRS_PLINK_1.99526231496888e.08 FALSE 433.31 Transient cerebral ischemia Both 56 351 8 circulatory system red 351, 56 49, 6 120, 23 51, 4 88, 19 0.0455 0.159 0.774 0.111 1.05 0.724 1.38 0.271 0.483 0.575 0.24 1.31 0.529 3.65 -0.428 0.636 0.501 0.301 0.652 0.167 2.33 0.13 0.512 0.799 0.097 1.14 0.425 3.32 PRS_PLINK_1.99526231496888e.08 FALSE 433.5 Cerebral aneurysm Both 11 104 8 circulatory system red 104, 11 18, 2 33, 2 17, 3 26, 3 0.124 0.253 0.624 0.205 1.13 0.584 1.74 -1.09 1.09 0.316 0.5 0.336 0.0168 3.17 1.29 1.09 0.236 0.627 3.65 0.459 50.9 0.0884 1.05 0.933 0.03 1.09 0.0933 14.2 PRS_PLINK_1.99526231496888e.08 TRUE 433.6 Acute, but ill-defined cerebrovascular disease Both 15 79 8 circulatory system red 79, 15 16, 4 25, 4 14, 3 20, 4 0.306 0.432 0.478 0.32 1.36 0.587 3.41 -2.47 1.24 0.0464 1.333 0.0846 0.00283 0.732 -0.383 0.873 0.661 0.18 0.682 0.116 3.49 -1.04 1.02 0.312 0.506 0.355 0.0282 2.4 PRS_PLINK_1.99526231496888e.08 TRUE 433.8 Late effects of cerebrovascular disease Both 18 127 8 circulatory system red 127, 18 18, 3 38, 3 24, 6 32, 6 0.197 0.216 0.362 0.441 1.22 0.785 1.83 -0.564 0.79 0.475 0.324 0.569 0.111 2.98 0.308 0.734 0.674 0.171 1.36 0.338 6.19 0.00255 0.772 0.997 0.001 1 0.224 4.95 PRS_PLINK_1.99526231496888e.08 TRUE 440 Atherosclerosis Both 74 287 8 circulatory system red 287, 74 43, 4 102, 38 41, 8 72, 14 -0.226 0.172 0.189 0.723 0.798 0.563 1.11 1.14 0.528 0.0303 1.518 3.14 1.21 10.2 0.735 0.635 0.247 0.607 2.09 0.619 8.16 0.299 0.601 0.619 0.209 1.35 0.425 4.94 PRS_PLINK_1.99526231496888e.08 FALSE 440.1 Atherosclerosis of renal artery Both 9 25 8 circulatory system red 25, 9 4, 0 5, 2 6, 3 6, 3 -0.514 0.684 0.453 0.344 0.598 0.116 2.02 -0.889 5.48 0.871 0.06 0.411 0.381 0.456 0.486 1.86 0.793 0.1 1.63 0.0759 495 0.0875 2.06 0.966 0.015 1.09 0.0259 47.6 PRS_PLINK_1.99526231496888e.08 TRUE 440.2 Atherosclerosis of the extremities Both 47 198 8 circulatory system red 198, 47 31, 4 50, 18 48, 9 50, 11 -0.0554 0.166 0.738 0.132 0.946 0.638 1.25 0.845 0.594 0.155 0.809 2.33 0.776 8.35 0.328 0.616 0.594 0.226 1.39 0.434 5.04 0.156 0.668 0.815 0.089 1.17 0.322 4.75 PRS_PLINK_1.99526231496888e.08 TRUE 440.21 Atherosclerosis of native arteries of the extremities with ulceration or gangrene Both 4 25 8 circulatory system red 25, 4 5, 1 9, 2 3, 0 6, 0 -0.193 0.892 0.829 0.081 0.825 0.0498 71.4 0.655 1.64 0.69 0.161 1.93 0.128 77.6 -1.95 50.9 0.969 0.013 0.142 4.19e-05 3280 -0.726 3.72 0.845 0.073 0.484 1.55e-09 4470 PRS_PLINK_1.99526231496888e.08 TRUE 440.22 Atherosclerosis of native arteries of the extremities with intermittent claudication Both 37 126 8 circulatory system red 126, 37 18, 2 32, 12 30, 8 32, 12 0.212 0.247 0.391 0.408 1.24 0.769 2.01 1.59 0.851 0.0623 1.206 4.89 1.1 35 0.391 0.773 0.613 0.212 1.48 0.348 7.88 0.992 0.813 0.222 0.653 2.7 0.636 17.9 PRS_PLINK_1.99526231496888e.08 TRUE 440.9 Atherosclerosis of aorta Both 27 81 8 circulatory system red 81, 27 15, 2 22, 15 18, 5 20, 1 -0.542 0.312 0.083 1.081 0.582 0.311 1.05 0.979 0.792 0.216 0.665 2.66 0.646 14.9 0.446 0.889 0.615 0.211 1.56 0.3 10.1 -1.41 1.2 0.239 0.622 0.244 0.00752 2.44 PRS_PLINK_1.99526231496888e.08 TRUE 441 Vascular insufficiency of intestine Both 18 87 8 circulatory system red 87, 18 10, 1 23, 2 20, 8 22, 4 0.0929 0.237 0.695 0.158 1.1 0.643 1.64 -0.0186 1.25 0.988 0.005 0.982 0.0707 21.8 0.982 1.04 0.347 0.459 2.67 0.451 31.9 -0.111 1.32 0.933 0.03 0.895 0.0504 15.8 PRS_PLINK_1.99526231496888e.08 TRUE 441.1 Acute vascular insufficiency of intestine Both 10 46 8 circulatory system red 46, 10 8, 0 16, 1 6, 3 12, 3 -0.0414 0.281 0.883 0.054 0.959 0.463 1.5 0.4 1.39 0.773 0.112 1.49 0.0584 131 1.12 1.5 0.455 0.342 3.07 0.266 238 1.11 1.77 0.532 0.274 3.02 0.133 241 PRS_PLINK_1.99526231496888e.08 TRUE 441.2 Chronic vascular insufficiency of intestine Both 3 24 8 circulatory system red 24, 3 3, 0 6, 1 6, 2 6, 0 0.452 0.936 0.629 0.201 1.57 0.191 4840 0.455 2.97 0.878 0.057 1.58 0.0232 208 0.596 3.14 0.849 0.071 1.81 0.00296 7720 PRS_PLINK_1.99526231496888e.08 TRUE 442 Other aneurysm Both 68 323 8 circulatory system red 323, 68 46, 10 112, 25 49, 13 81, 15 0.0757 0.163 0.642 0.192 1.08 0.775 1.46 0.0192 0.443 0.965 0.015 1.02 0.44 2.48 0.285 0.493 0.564 0.249 1.33 0.518 3.52 -0.149 0.455 0.743 0.129 0.861 0.357 2.13 PRS_PLINK_1.99526231496888e.08 FALSE 442.1 Aortic aneurysm Both 47 192 8 circulatory system red 192, 47 29, 8 59, 18 38, 9 47, 8 0.0153 0.229 0.947 0.024 1.02 0.652 1.59 0.0694 0.512 0.892 0.05 1.07 0.411 2.96 0.243 0.62 0.695 0.158 1.28 0.392 4.4 -0.338 0.56 0.546 0.263 0.713 0.241 2.12 PRS_PLINK_1.99526231496888e.08 TRUE 442.11 Abdominal aortic aneurysm Both 24 106 8 circulatory system red 106, 24 20, 5 27, 9 26, 3 26, 5 -0.13 0.355 0.713 0.147 0.878 0.441 1.76 0.171 0.779 0.826 0.083 1.19 0.277 5.75 -0.865 1.08 0.423 0.374 0.421 0.0309 4.13 -0.572 0.833 0.493 0.307 0.565 0.11 2.8 PRS_PLINK_1.99526231496888e.08 TRUE 442.2 Aneurysm of iliac artery Both 2 25 8 circulatory system red 25, 2 6, 0 6, 2 6, 0 6, 0 -0.27 0.815 0.741 0.13 0.764 0.0742 4.09 1.52 1.62 0.35 0.456 4.55 0.426 3160 PRS_PLINK_1.99526231496888e.08 TRUE 442.3 Aneurysm of artery of lower extremity Both 3 31 8 circulatory system red 31, 3 4, 1 10, 1 5, 0 8, 1 -0.197 0.77 0.798 0.098 0.821 0.122 6.15 -0.962 1.62 0.553 0.257 0.382 0.00115 8.41 1.85 9.14 0.84 0.076 6.36 9.23e-07 43100000 -0.634 1.93 0.742 0.129 0.53 0.00335 31.1 PRS_PLINK_1.99526231496888e.08 TRUE 442.4 Arterial dissection Both 6 34 8 circulatory system red 34, 6 7, 0 8, 1 8, 2 9, 3 1.69 0.947 0.0743 1.129 5.42 1.03 61.4 0.897 1.99 0.652 0.186 2.45 0.0581 4160 1.1 1.96 0.575 0.24 3.01 0.0143 3090000 2.25 2.04 0.269 0.57 9.52 0.4 1120000 PRS_PLINK_1.99526231496888e.08 TRUE 442.8 Aneurysm of other specified artery Both 15 65 8 circulatory system red 65, 15 6, 0 17, 6 15, 3 16, 5 0.126 0.26 0.628 0.202 1.13 0.618 1.73 0.732 1.49 0.624 0.205 2.08 0.0582 233 1.04 1.83 0.571 0.243 2.82 0.0768 2050 1.14 2.09 0.585 0.233 3.13 0.000976 231000 PRS_PLINK_1.99526231496888e.08 TRUE 443 Peripheral vascular disease Both 103 492 8 circulatory system red 492, 103 66, 11 174, 37 73, 16 121, 26 -0.0525 0.112 0.639 0.195 0.949 0.739 1.16 0.163 0.37 0.659 0.181 1.18 0.586 2.52 0.239 0.416 0.565 0.248 1.27 0.564 2.93 0.127 0.39 0.745 0.128 1.14 0.538 2.51 PRS_PLINK_1.99526231496888e.08 FALSE 443.1 Raynaud's syndrome Both 45 233 8 circulatory system red 233, 45 32, 7 84, 14 33, 7 57, 12 -0.0244 0.168 0.884 0.053 0.976 0.667 1.31 -0.556 0.535 0.298 0.525 0.573 0.197 1.67 0.14 0.6 0.816 0.088 1.15 0.357 3.77 -0.295 0.545 0.589 0.23 0.745 0.256 2.2 PRS_PLINK_1.99526231496888e.08 TRUE 443.7 Peripheral angiopathy in diseases classified elsewhere Both 6 33 8 circulatory system red 33, 6 4, 0 8, 3 8, 2 8, 1 0.518 0.62 0.403 0.394 1.68 0.528 7.07 0.185 2.03 0.928 0.033 1.2 0.00617 1800 0.0669 1.66 0.968 0.014 1.07 0.0107 38.5 -0.936 2.9 0.747 0.127 0.392 0.000195 33 PRS_PLINK_1.99526231496888e.08 TRUE 443.8 Other specified peripheral vascular diseases Both 87 414 8 circulatory system red 414, 87 67, 9 138, 32 64, 12 103, 23 -0.0522 0.121 0.666 0.176 0.949 0.72 1.17 0.413 0.398 0.299 0.524 1.51 0.713 3.46 0.18 0.468 0.701 0.154 1.2 0.472 3.08 0.399 0.411 0.332 0.479 1.49 0.679 3.49 PRS_PLINK_1.99526231496888e.08 FALSE 443.9 Peripheral vascular disease, unspecified Both 58 271 8 circulatory system red 271, 58 42, 5 95, 21 40, 8 68, 14 -0.153 0.162 0.346 0.461 0.858 0.592 1.13 0.446 0.508 0.381 0.419 1.56 0.604 4.67 0.482 0.593 0.416 0.381 1.62 0.515 5.42 0.444 0.553 0.422 0.375 1.56 0.546 5.01 PRS_PLINK_1.99526231496888e.08 FALSE 444 Arterial embolism and thrombosis Both 28 160 8 circulatory system red 160, 28 27, 6 55, 13 25, 6 40, 3 -0.0307 0.246 0.901 0.045 0.97 0.518 1.46 -0.279 0.588 0.636 0.197 0.757 0.238 2.47 0.26 0.68 0.702 0.154 1.3 0.354 4.78 -2.31 1.1 0.0356 1.449 0.0988 0.0036 0.73 PRS_PLINK_1.99526231496888e.08 TRUE 444.1 Arterial embolism and thrombosis of lower extremity artery Both 8 57 8 circulatory system red 57, 8 8, 2 15, 4 13, 2 14, 0 -0.393 0.48 0.413 0.384 0.675 0.235 1.73 -0.242 1.12 0.829 0.081 0.785 0.103 6.68 -0.846 1.17 0.47 0.328 0.429 0.0329 3.4 -1.83 1.44 0.202 0.694 0.16 3.2e-07 1.81 PRS_PLINK_1.99526231496888e.08 TRUE 444.2 Embolism and thrombosis of abdominal aorta Both 3 21 8 circulatory system red 21, 3 6, 1 5, 0 5, 0 5, 2 1.83 1.41 0.194 0.712 6.26 0.162 24800 0.417 3.44 0.904 0.044 1.52 0.000497 4780 -0.34 2.16 0.875 0.058 0.712 0.0015 323 2.56 2.27 0.259 0.587 12.9 0.412 29400 PRS_PLINK_1.99526231496888e.08 TRUE 446 Polyarteritis nodosa and allied conditions Both 19 80 8 circulatory system red 80, 19 11, 4 22, 4 18, 2 20, 4 -0.535 0.34 0.115 0.939 0.586 0.294 1.11 -0.477 0.951 0.616 0.21 0.621 0.106 3.83 -0.859 0.968 0.375 0.426 0.424 0.0604 2.54 -1.14 0.935 0.222 0.653 0.319 0.0448 1.77 PRS_PLINK_1.99526231496888e.08 TRUE 446.4 Wegener's granulomatosis Both 4 15 8 circulatory system red 15, 4 3, 1 4, 1 3, 0 4, 1 -0.789 1.37 0.566 0.247 0.454 0.0422 4.29 1.24 198 0.995 0.002 3.46 0.514 50.9 -1.19 438 0.998 0.001 0.306 0.0569 4.23 -0.362 4.62 0.938 0.028 0.696 0.62 0.866 PRS_PLINK_1.99526231496888e.08 TRUE 446.5 Giant cell arteritis Both 0 6 8 circulatory system red 6, 0 1 1 1 2 PRS_PLINK_1.99526231496888e.08 TRUE 446.9 Arteritis NOS Both 14 60 8 circulatory system red 60, 14 9, 4 17, 2 13, 2 15, 4 -0.297 0.415 0.475 0.323 0.743 0.321 1.63 -1 1.01 0.323 0.49 0.368 0.025 2.24 -0.688 1.23 0.577 0.239 0.503 0.0183 5.49 -0.503 0.892 0.573 0.242 0.605 0.111 3.02 PRS_PLINK_1.99526231496888e.08 TRUE 447 Other disorders of arteries and arterioles Both 76 396 8 circulatory system red 396, 76 59, 14 139, 23 58, 11 99, 20 0.0424 0.152 0.78 0.108 1.04 0.766 1.39 -0.501 0.392 0.201 0.696 0.606 0.282 1.32 -0.0938 0.442 0.832 0.08 0.91 0.381 2.15 -0.303 0.389 0.436 0.361 0.738 0.344 1.6 PRS_PLINK_1.99526231496888e.08 FALSE 447.1 Stricture of artery Both 11 80 8 circulatory system red 80, 11 15, 2 23, 3 16, 1 20, 3 -0.304 0.442 0.491 0.309 0.738 0.308 1.71 0.133 1.1 0.904 0.044 1.14 0.115 10.4 -1.01 1.56 0.516 0.287 0.363 1.94e-06 6.5 -1.19 1.43 0.403 0.395 0.303 0.00242 4.71 PRS_PLINK_1.99526231496888e.08 TRUE 447.7 Aortic ectasia Both 27 102 8 circulatory system red 102, 27 14, 4 25, 6 24, 5 26, 8 0.000274 0.293 0.999 0 1 0.564 1.78 -0.371 0.756 0.623 0.205 0.69 0.16 2.94 -0.5 0.899 0.578 0.238 0.606 0.101 3.17 -0.0364 0.708 0.959 0.018 0.964 0.256 3.87 PRS_PLINK_1.99526231496888e.08 TRUE 448 Disease of capillaries Both 48 274 8 circulatory system red 274, 48 38, 4 81, 14 55, 7 69, 18 0.0859 0.121 0.476 0.322 1.09 0.831 1.34 0.11 0.58 0.849 0.071 1.12 0.363 3.98 -0.0737 0.658 0.911 0.041 0.929 0.255 3.73 0.468 0.576 0.417 0.38 1.6 0.534 5.59 PRS_PLINK_1.99526231496888e.08 TRUE 450 Noninfectious disorders of lymphatic channels Both 103 521 8 circulatory system red 521, 103 84, 17 173, 29 87, 16 130, 29 -0.0404 0.13 0.756 0.121 0.96 0.735 1.23 -0.225 0.334 0.501 0.3 0.799 0.417 1.56 -0.168 0.388 0.664 0.178 0.845 0.393 1.8 0.0422 0.341 0.902 0.045 1.04 0.538 2.06 PRS_PLINK_1.99526231496888e.08 FALSE 451 Phlebitis and thrombophlebitis Both 31 143 8 circulatory system red 143, 31 24, 10 51, 6 20, 5 36, 9 -0.000996 0.277 0.997 0.001 0.999 0.582 1.73 -0.946 0.597 0.113 0.947 0.388 0.115 1.23 -0.614 0.714 0.39 0.409 0.541 0.128 1.98 -0.332 0.591 0.574 0.241 0.717 0.231 2.2 PRS_PLINK_1.99526231496888e.08 TRUE 451.2 Phlebitis and thrombophlebitis of lower extremities Both 9 50 8 circulatory system red 50, 9 8, 2 16, 2 8, 2 13, 2 0.129 0.524 0.805 0.094 1.14 0.422 3.37 0.565 1.28 0.658 0.182 1.76 0.158 2250 0.711 1.79 0.69 0.161 2.04 0.0758 152 0.513 1.48 0.728 0.138 1.67 0.122 40.6 PRS_PLINK_1.99526231496888e.08 TRUE 452 Other venous embolism and thrombosis Both 129 624 8 circulatory system red 624, 129 92, 17 154, 26 157, 36 155, 37 0.109 0.085 0.201 0.697 1.11 0.936 1.3 -0.0876 0.349 0.802 0.096 0.916 0.465 1.84 0.171 0.325 0.6 0.222 1.19 0.634 2.29 0.212 0.332 0.523 0.282 1.24 0.655 2.41 PRS_PLINK_1.99526231496888e.08 FALSE 452.1 Iatrogenic pulmonary embolism and infarction Both 21 55 8 circulatory system red 55, 21 11, 4 14, 4 13, 6 14, 6 0.226 0.28 0.421 0.376 1.25 0.584 2.5 -0.706 0.966 0.465 0.333 0.494 0.0673 2.76 0.517 0.873 0.553 0.257 1.68 0.364 10.6 -0.0719 0.853 0.933 0.03 0.931 0.194 4.47 PRS_PLINK_1.99526231496888e.08 TRUE 452.2 Deep vein thrombosis [DVT] Both 78 501 8 circulatory system red 501, 78 77, 10 124, 20 123, 15 125, 26 0.167 0.0973 0.0861 1.065 1.18 0.973 1.41 0.16 0.409 0.696 0.157 1.17 0.529 2.73 -0.139 0.419 0.74 0.131 0.87 0.378 2.07 0.438 0.387 0.258 0.589 1.55 0.74 3.46 PRS_PLINK_1.99526231496888e.08 FALSE 452.8 Postphlebitic syndrome Both 6 30 8 circulatory system red 30, 6 5, 1 8, 2 6, 0 8, 3 0.296 0.611 0.629 0.202 1.34 0.432 4.9 0.161 1.36 0.906 0.043 1.17 0.137 15.8 -0.0752 2.01 0.97 0.013 0.928 0.00379 419 0.16 1.29 0.901 0.045 1.17 0.127 11.1 PRS_PLINK_1.99526231496888e.08 TRUE 453 Chronic venous hypertension Both 15 41 8 circulatory system red 41, 15 8, 0 14, 5 6, 2 10, 5 -0.0204 0.207 0.922 0.035 0.98 0.361 1.31 0.887 1.33 0.506 0.296 2.43 0.2 307 1.04 2.42 0.668 0.175 2.83 0.00221 2280000 1.14 1.75 0.516 0.288 3.12 0.00451 5.39e+10 PRS_PLINK_1.99526231496888e.08 TRUE 454 Varicose veins Both 157 458 8 circulatory system red 458, 157 63, 17 115, 38 113, 36 115, 52 0.12 0.105 0.253 0.597 1.13 0.918 1.38 0.212 0.352 0.547 0.262 1.24 0.632 2.49 0.204 0.344 0.553 0.257 1.23 0.635 2.44 0.43 0.335 0.199 0.701 1.54 0.814 3 PRS_PLINK_1.99526231496888e.08 FALSE 454.1 Varicose veins of lower extremity Both 131 415 8 circulatory system red 415, 131 58, 18 153, 43 53, 15 104, 41 0.147 0.122 0.229 0.641 1.16 0.909 1.46 -0.127 0.334 0.703 0.153 0.881 0.465 1.71 -0.0486 0.423 0.909 0.042 0.953 0.417 2.15 0.116 0.342 0.735 0.134 1.12 0.583 2.2 PRS_PLINK_1.99526231496888e.08 FALSE 454.11 Varicose veins of lower extremity, symptomtic Both 98 282 8 circulatory system red 282, 98 45, 18 98, 28 42, 11 71, 31 0.0947 0.146 0.516 0.287 1.1 0.814 1.44 -0.407 0.366 0.267 0.574 0.666 0.329 1.36 -0.446 0.478 0.351 0.455 0.64 0.248 1.58 -0.0576 0.373 0.877 0.057 0.944 0.463 1.94 PRS_PLINK_1.99526231496888e.08 FALSE 455 Hemorrhoids Both 285 655 8 circulatory system red 655, 285 95, 35 224, 100 101, 41 164, 77 0.0783 0.0773 0.311 0.507 1.08 0.927 1.25 0.0614 0.25 0.806 0.094 1.06 0.658 1.74 -0.0168 0.296 0.955 0.02 0.983 0.553 1.75 0.17 0.259 0.511 0.292 1.19 0.721 1.97 PRS_PLINK_1.99526231496888e.08 FALSE 456 Chronic venous insufficiency [CVI] Both 184 523 8 circulatory system red 523, 184 73, 26 186, 65 77, 18 129, 57 0.0401 0.0906 0.658 0.182 1.04 0.862 1.23 -0.0663 0.278 0.811 0.091 0.936 0.551 1.62 -0.518 0.368 0.159 0.798 0.596 0.287 1.21 0.0847 0.288 0.769 0.114 1.09 0.626 1.92 PRS_PLINK_1.99526231496888e.08 FALSE 457 Encounter for long-term (current) use of anticoagulants, antithrombotics, aspirin Both 37 185 8 circulatory system red 185, 37 29, 3 48, 12 43, 6 46, 12 0.189 0.255 0.458 0.339 1.21 0.735 2.02 0.592 0.674 0.379 0.421 1.81 0.509 8.15 0.18 0.713 0.8 0.097 1.2 0.304 5.52 1.01 0.704 0.153 0.814 2.73 0.752 13.3 PRS_PLINK_1.99526231496888e.08 TRUE 457.2 Encounter for long-term (current) use of antiplatelets/antithrombotics Both 4 27 8 circulatory system red 27, 4 6, 1 9, 0 4, 1 7, 0 -1.33 1.13 0.243 0.615 0.266 0.00103 1.72 -0.191 1.72 0.912 0.04 0.826 0.00244 34.2 1.1 2.32 0.634 0.198 3.01 0.0143 215 -0.994 1.88 0.597 0.224 0.37 0.00413 8.78 PRS_PLINK_1.99526231496888e.08 TRUE 457.3 Encounter for long-term (current) use of aspirin Both 35 174 8 circulatory system red 174, 35 25, 3 49, 12 37, 5 44, 12 0.236 0.262 0.367 0.436 1.27 0.76 2.16 0.404 0.693 0.56 0.252 1.5 0.405 6.94 0.118 0.726 0.871 0.06 1.12 0.274 5.3 0.978 0.734 0.183 0.739 2.66 0.701 14 PRS_PLINK_1.99526231496888e.08 TRUE 458 Hypotension Both 167 793 8 circulatory system red 793, 167 110, 22 282, 65 118, 22 194, 42 0.042 0.0819 0.608 0.216 1.04 0.876 1.21 0.0905 0.276 0.743 0.129 1.09 0.646 1.91 -0.123 0.333 0.712 0.147 0.884 0.457 1.71 0.035 0.296 0.906 0.043 1.04 0.585 1.87 PRS_PLINK_1.99526231496888e.08 FALSE 458.1 Orthostatic hypotension Both 63 268 8 circulatory system red 268, 63 41, 11 94, 19 39, 8 67, 19 0.116 0.124 0.349 0.457 1.12 0.865 1.41 -0.46 0.441 0.297 0.527 0.632 0.268 1.51 -0.263 0.526 0.618 0.209 0.769 0.266 2.12 -0.0106 0.438 0.981 0.008 0.989 0.428 2.35 PRS_PLINK_1.99526231496888e.08 FALSE 458.2 Iatrogenic hypotension Both 33 171 8 circulatory system red 171, 33 28, 4 60, 11 25, 8 43, 7 0.102 0.174 0.557 0.254 1.11 0.727 1.48 0.0322 0.625 0.959 0.018 1.03 0.316 3.81 0.855 0.668 0.201 0.697 2.35 0.683 9.33 0.362 0.742 0.626 0.203 1.44 0.35 6.98 PRS_PLINK_1.99526231496888e.08 TRUE 458.9 Hypotension NOS Both 147 738 8 circulatory system red 738, 147 102, 20 265, 55 108, 21 180, 35 0.0303 0.0867 0.727 0.138 1.03 0.856 1.21 0.015 0.288 0.958 0.018 1.02 0.586 1.81 -0.0728 0.34 0.83 0.081 0.93 0.474 1.82 -0.0908 0.31 0.77 0.114 0.913 0.501 1.7 PRS_PLINK_1.99526231496888e.08 FALSE 459 Other disorders of circulatory system Both 242 912 8 circulatory system red 912, 242 129, 23 312, 85 145, 43 227, 67 0.0547 0.0717 0.446 0.351 1.06 0.911 1.21 0.269 0.264 0.308 0.511 1.31 0.79 2.23 0.466 0.299 0.119 0.925 1.59 0.895 2.89 0.387 0.274 0.157 0.803 1.47 0.871 2.55 PRS_PLINK_1.99526231496888e.08 FALSE 459.1 Hemorrhage NOS Both 39 181 8 circulatory system red 181, 39 21, 1 67, 19 24, 9 44, 6 0.102 0.191 0.594 0.226 1.11 0.745 1.57 1.5 0.872 0.0844 1.074 4.5 1.02 42.1 1.39 0.904 0.123 0.91 4.03 0.819 40.5 0.917 1.01 0.364 0.439 2.5 0.421 29.2 PRS_PLINK_1.99526231496888e.08 TRUE 459.7 Blood vessel replaced Both 29 243 8 circulatory system red 243, 29 40, 7 87, 10 32, 2 61, 9 0.268 0.192 0.162 0.791 1.31 0.936 2 -0.512 0.512 0.318 0.498 0.599 0.217 1.71 -0.979 0.741 0.187 0.729 0.376 0.0685 1.53 -0.176 0.532 0.741 0.13 0.839 0.293 2.47 PRS_PLINK_1.99526231496888e.08 TRUE 459.9 Circulatory disease NEC Both 203 860 8 circulatory system red 860, 203 126, 22 294, 66 136, 35 215, 59 0.019 0.0821 0.817 0.088 1.02 0.858 1.19 0.0679 0.277 0.806 0.093 1.07 0.629 1.87 0.39 0.313 0.212 0.674 1.48 0.808 2.75 0.333 0.282 0.238 0.623 1.39 0.812 2.46 PRS_PLINK_1.99526231496888e.08 FALSE 464 Acute sinusitis Both 384 505 9 respiratory coral4 505, 384 72, 42 169, 129 83, 53 125, 120 0.0866 0.0746 0.245 0.61 1.09 0.946 1.26 0.253 0.235 0.281 0.551 1.29 0.82 2.04 -0.0419 0.276 0.88 0.056 0.959 0.562 1.63 0.446 0.24 0.0625 1.204 1.56 0.987 2.49 PRS_PLINK_1.99526231496888e.08 FALSE 465 Acute upper respiratory infections of multiple or unspecified sites Both 675 529 9 respiratory coral4 529, 675 77, 73 177, 248 87, 85 131, 201 0.0819 0.0605 0.176 0.755 1.09 0.968 1.23 0.391 0.196 0.0459 1.338 1.48 1.01 2.16 0.0132 0.23 0.954 0.02 1.01 0.65 1.58 0.444 0.202 0.028 1.552 1.56 1.05 2.31 PRS_PLINK_1.99526231496888e.08 FALSE 465.2 Acute pharyngitis Both 454 512 9 respiratory coral4 512, 454 74, 53 171, 174 85, 52 126, 132 0.0502 0.0671 0.454 0.343 1.05 0.925 1.2 0.363 0.216 0.0926 1.034 1.44 0.949 2.19 -0.196 0.264 0.459 0.338 0.822 0.494 1.37 0.344 0.225 0.126 0.898 1.41 0.914 2.19 PRS_PLINK_1.99526231496888e.08 FALSE 465.4 Acute laryngitis and tracheitis Both 27 74 9 respiratory coral4 74, 27 12, 4 23, 11 13, 3 19, 6 0.00789 0.305 0.979 0.009 1.01 0.559 1.82 0.962 0.833 0.248 0.605 2.62 0.591 15.4 -0.117 1.02 0.909 0.041 0.89 0.113 6.52 -0.0348 0.792 0.965 0.015 0.966 0.229 4.37 PRS_PLINK_1.99526231496888e.08 TRUE 470 Septal Deviations/Turbinate Hypertrophy Both 83 295 9 respiratory coral4 295, 83 52, 9 97, 27 47, 18 74, 20 0.133 0.104 0.201 0.697 1.14 0.926 1.38 0.505 0.438 0.249 0.604 1.66 0.724 4.09 0.565 0.47 0.229 0.64 1.76 0.718 4.5 0.369 0.447 0.409 0.389 1.45 0.617 3.57 PRS_PLINK_1.99526231496888e.08 FALSE 471 Nasal polyps Both 24 97 9 respiratory coral4 97, 24 14, 4 29, 6 19, 8 24, 4 0.152 0.305 0.618 0.209 1.16 0.649 2.16 -0.385 0.785 0.624 0.205 0.681 0.15 3.25 0.111 0.76 0.884 0.054 1.12 0.282 4.76 -0.0847 0.844 0.92 0.036 0.919 0.184 5.68 PRS_PLINK_1.99526231496888e.08 TRUE 472 Chronic pharyngitis and nasopharyngitis Both 121 303 9 respiratory coral4 303, 121 48, 13 96, 41 55, 18 75, 31 0.0329 0.0918 0.72 0.142 1.03 0.853 1.22 0.429 0.382 0.262 0.582 1.54 0.749 3.29 -0.0376 0.448 0.933 0.03 0.963 0.407 2.29 0.302 0.394 0.444 0.353 1.35 0.642 2.95 PRS_PLINK_1.99526231496888e.08 FALSE 473 Diseases of the larynx and vocal cords Both 98 385 9 respiratory coral4 385, 98 59, 13 117, 32 76, 18 95, 25 0.0547 0.112 0.626 0.203 1.06 0.821 1.29 0.103 0.375 0.784 0.106 1.11 0.541 2.36 -0.199 0.435 0.646 0.189 0.819 0.347 1.93 0.0475 0.389 0.903 0.044 1.05 0.494 2.29 PRS_PLINK_1.99526231496888e.08 FALSE 473.1 Chronic laryngitis Both 2 8 9 respiratory coral4 8, 2 2, 2 3, 0 1, 0 2, 0 0.14 1.51 0.926 0.033 1.15 0.112 17.4 -0.871 188 0.996 0.002 0.419 0.0297 6.55 0.6 432 0.999 0 1.82 0.00219 2140 -4.3 24600000 1 0 0.0136 8.99e-09 532000 PRS_PLINK_1.99526231496888e.08 TRUE 473.3 Paralysis/spasm of vocal cords or larynx Both 21 91 9 respiratory coral4 91, 21 16, 1 28, 8 16, 5 23, 5 0.228 0.346 0.51 0.292 1.26 0.648 2.55 0.889 0.905 0.326 0.487 2.43 0.487 23.3 1.27 1.22 0.3 0.523 3.55 0.362 151 1.32 1.08 0.225 0.647 3.73 0.498 54 PRS_PLINK_1.99526231496888e.08 TRUE 473.4 Voice disturbance Both 68 302 9 respiratory coral4 302, 68 51, 8 90, 23 58, 12 76, 19 0.104 0.173 0.548 0.261 1.11 0.766 1.52 0.28 0.446 0.531 0.275 1.32 0.566 3.32 -0.0644 0.525 0.902 0.045 0.938 0.332 2.66 0.374 0.465 0.421 0.375 1.45 0.594 3.79 PRS_PLINK_1.99526231496888e.08 FALSE 474 Acute and chronic tonsillitis Both 59 250 9 respiratory coral4 250, 59 40, 7 74, 21 51, 13 62, 11 -0.0621 0.153 0.685 0.164 0.94 0.646 1.21 0.461 0.502 0.358 0.446 1.59 0.619 4.46 0.406 0.512 0.428 0.369 1.5 0.568 4.28 0.0943 0.527 0.858 0.067 1.1 0.396 3.24 PRS_PLINK_1.99526231496888e.08 FALSE 474.1 Acute tonsillitis Both 28 115 9 respiratory coral4 115, 28 19, 3 34, 10 22, 6 29, 6 0.0146 0.169 0.931 0.031 1.01 0.637 1.31 0.497 0.818 0.544 0.264 1.64 0.371 9.7 0.39 0.839 0.642 0.193 1.48 0.307 8.08 0.108 0.852 0.899 0.046 1.11 0.207 6.53 PRS_PLINK_1.99526231496888e.08 TRUE 474.2 Chronic tonsillitis and adenoiditis Both 45 206 9 respiratory coral4 206, 45 31, 5 64, 19 39, 8 51, 7 -0.103 0.182 0.573 0.242 0.902 0.576 1.22 0.617 0.568 0.277 0.557 1.85 0.644 6.19 -0.0013 0.612 0.998 0.001 0.999 0.301 3.47 -0.168 0.643 0.793 0.101 0.845 0.228 3.26 PRS_PLINK_1.99526231496888e.08 TRUE 475 Chronic sinusitis Both 268 459 9 respiratory coral4 459, 268 73, 39 140, 91 88, 53 115, 61 0.0142 0.0775 0.855 0.068 1.01 0.866 1.17 0.147 0.253 0.561 0.251 1.16 0.712 1.9 0.0505 0.273 0.854 0.069 1.05 0.622 1.78 -0.016 0.265 0.952 0.021 0.984 0.59 1.65 PRS_PLINK_1.99526231496888e.08 FALSE 475.9 Postnasal drip Both 57 156 9 respiratory coral4 156, 57 25, 16 43, 18 35, 8 39, 10 -0.207 0.192 0.281 0.552 0.813 0.525 1.12 -0.361 0.456 0.428 0.368 0.697 0.295 1.65 -1.14 0.551 0.0379 1.421 0.319 0.105 0.882 -0.911 0.517 0.078 1.108 0.402 0.146 1.05 PRS_PLINK_1.99526231496888e.08 FALSE 476 Allergic rhinitis Both 617 462 9 respiratory coral4 462, 617 73, 99 142, 204 88, 99 116, 147 -0.0467 0.0635 0.462 0.335 0.954 0.841 1.08 0.0461 0.199 0.817 0.088 1.05 0.711 1.54 -0.327 0.224 0.145 0.838 0.721 0.466 1.11 -0.078 0.207 0.707 0.151 0.925 0.618 1.38 PRS_PLINK_1.99526231496888e.08 FALSE 477 Epistaxis or throat hemorrhage Both 57 180 9 respiratory coral4 180, 57 25, 8 60, 19 30, 6 45, 15 0.163 0.195 0.405 0.392 1.18 0.804 1.72 -0.3 0.528 0.57 0.244 0.741 0.27 2.09 -0.447 0.661 0.499 0.302 0.639 0.17 2.25 0.286 0.572 0.617 0.21 1.33 0.451 4.08 PRS_PLINK_1.99526231496888e.08 FALSE 478 Throat pain Both 28 80 9 respiratory coral4 80, 28 12, 6 20, 9 20, 5 20, 6 -0.12 0.297 0.686 0.164 0.887 0.503 1.57 -0.393 0.715 0.582 0.235 0.675 0.178 2.52 -0.756 0.857 0.378 0.422 0.47 0.0882 2.22 -0.831 0.809 0.304 0.517 0.436 0.0794 1.97 PRS_PLINK_1.99526231496888e.08 TRUE 479 Other upper respiratory disease Both 280 462 9 respiratory coral4 462, 280 73, 32 142, 105 88, 44 116, 67 -0.0474 0.0819 0.563 0.25 0.954 0.806 1.11 0.538 0.265 0.0423 1.373 1.71 1.03 2.89 0.0131 0.298 0.965 0.015 1.01 0.571 1.8 0.244 0.273 0.373 0.429 1.28 0.755 2.18 PRS_PLINK_1.99526231496888e.08 FALSE 480 Pneumonia Both 234 795 9 respiratory coral4 795, 234 114, 29 265, 83 133, 34 195, 65 -0.0135 0.0751 0.857 0.067 0.987 0.844 1.13 0.121 0.251 0.63 0.2 1.13 0.696 1.87 -0.0517 0.291 0.859 0.066 0.95 0.538 1.68 0.204 0.259 0.43 0.366 1.23 0.745 2.05 PRS_PLINK_1.99526231496888e.08 FALSE 480.1 Bacterial pneumonia Both 42 185 9 respiratory coral4 185, 42 33, 6 65, 16 26, 4 46, 14 0.202 0.135 0.134 0.873 1.22 0.955 1.59 0.508 0.529 0.337 0.473 1.66 0.621 4.96 -0.172 0.662 0.795 0.1 0.842 0.216 3.03 0.48 0.54 0.374 0.427 1.62 0.585 4.9 PRS_PLINK_1.99526231496888e.08 TRUE 480.11 Pneumococcal pneumonia Both 29 91 9 respiratory coral4 91, 29 14, 2 23, 12 22, 3 23, 11 0.483 0.323 0.135 0.87 1.62 0.884 3.06 1.36 0.922 0.141 0.851 3.89 0.787 33.1 0.146 1.07 0.891 0.05 1.16 0.155 10.6 1.34 0.985 0.173 0.761 3.82 0.644 38.2 PRS_PLINK_1.99526231496888e.08 TRUE 480.12 Pseudomonal pneumonia Both 3 22 9 respiratory coral4 22, 3 8, 1 3, 0 5, 0 6, 2 0.167 0.267 0.533 0.274 1.18 0.559 4.55 -1.31 2.17 0.545 0.264 0.268 0.000957 6.66 -0.481 2.28 0.833 0.079 0.618 0.00286 105 2.61 2.63 0.322 0.493 13.6 0.202 17 PRS_PLINK_1.99526231496888e.08 TRUE 480.13 MRSA pneumonia Both 6 17 9 respiratory coral4 17, 6 6, 1 5, 5 2, 0 4, 0 -3.76 2.31 0.104 0.984 0.0233 6.54e-09 1.01 -0.816 2.36 0.729 0.137 0.442 0.00118 19.3 1.86 29 0.949 0.023 6.45 5.77 7.24 -2.01 6.25 0.748 0.126 0.134 3.87e-06 988 PRS_PLINK_1.99526231496888e.08 TRUE 480.2 Viral pneumonia Both 6 37 9 respiratory coral4 37, 6 8, 0 11, 2 7, 2 9, 1 -0.154 0.624 0.805 0.094 0.857 0.2 2.97 -0.417 1.55 0.787 0.104 0.659 0.0486 29 3.39 2.5 0.175 0.757 29.7 0.588 330000 -0.157 1.44 0.913 0.039 0.855 0.000517 58 PRS_PLINK_1.99526231496888e.08 TRUE 480.3 Pneumonia due to fungus (mycoses) Both 10 25 9 respiratory coral4 25, 10 5, 1 7, 2 5, 4 6, 1 0.00323 0.302 0.991 0.004 1 0.195 1.77 0.34 1.61 0.833 0.079 1.4 0.119 20.1 4.69 3.33 0.159 0.798 109 0.7 1.8e+14 -0.723 3.97 0.856 0.068 0.485 1.41e-05 13200 PRS_PLINK_1.99526231496888e.08 TRUE 480.5 Bronchopneumonia and lung abscess Both 0 13 9 respiratory coral4 13, 0 2 4 2 3 PRS_PLINK_1.99526231496888e.08 TRUE 481 Influenza Both 108 353 9 respiratory coral4 353, 108 52, 10 121, 47 55, 20 87, 23 -0.0324 0.105 0.759 0.12 0.968 0.764 1.16 0.68 0.396 0.0854 1.068 1.97 0.937 4.48 0.602 0.441 0.173 0.763 1.83 0.79 4.42 0.233 0.417 0.576 0.239 1.26 0.563 2.97 PRS_PLINK_1.99526231496888e.08 FALSE 483 Acute bronchitis and bronchiolitis Both 257 669 9 respiratory coral4 669, 257 97, 30 215, 100 121, 41 165, 61 -0.02 0.0752 0.79 0.102 0.98 0.839 1.13 0.287 0.251 0.252 0.598 1.33 0.823 2.19 -0.0306 0.289 0.915 0.038 0.97 0.554 1.7 0.0876 0.264 0.74 0.131 1.09 0.656 1.84 PRS_PLINK_1.99526231496888e.08 FALSE 495 Asthma Both 386 776 9 respiratory coral4 776, 386 119, 60 253, 121 134, 57 193, 102 -0.0121 0.0615 0.844 0.073 0.988 0.873 1.11 -0.0412 0.198 0.835 0.079 0.96 0.655 1.41 -0.179 0.229 0.434 0.363 0.836 0.536 1.3 0.0572 0.205 0.78 0.108 1.06 0.713 1.58 PRS_PLINK_1.99526231496888e.08 FALSE 495.1 Chronic obstructive asthma Both 16 85 9 respiratory coral4 85, 16 17, 0 22, 8 19, 1 21, 6 0.000834 0.372 0.998 0.001 1 0.482 2.11 2.63 1.34 0.0505 1.297 13.8 1.45 1900 -0.138 1.36 0.919 0.037 0.871 0.00664 76.3 1.43 1.33 0.282 0.55 4.18 0.329 2840 PRS_PLINK_1.99526231496888e.08 TRUE 495.11 Chronic obstructive asthma with exacerbation Both 5 19 9 respiratory coral4 19, 5 3, 1 5, 1 4, 1 5, 1 0.0517 0.708 0.942 0.026 1.05 0.261 3.72 0.46 2.51 0.855 0.068 1.58 0.0696 8380 1.23 11.3 0.913 0.039 3.41 3.01 3.97 1.38 6.99 0.843 0.074 3.98 3.55 4.42 PRS_PLINK_1.99526231496888e.08 TRUE 495.2 Asthma with exacerbation Both 146 512 9 respiratory coral4 512, 146 78, 20 133, 30 124, 42 127, 35 -0.015 0.09 0.868 0.061 0.985 0.814 1.16 -0.0825 0.33 0.803 0.095 0.921 0.486 1.77 0.162 0.314 0.605 0.218 1.18 0.644 2.19 0.0783 0.328 0.811 0.091 1.08 0.575 2.07 PRS_PLINK_1.99526231496888e.08 FALSE 496 Chronic airway obstruction Both 107 561 9 respiratory coral4 561, 107 83, 13 195, 41 85, 12 139, 27 -0.106 0.124 0.394 0.405 0.899 0.691 1.13 0.25 0.343 0.467 0.331 1.28 0.669 2.59 -0.118 0.427 0.782 0.107 0.888 0.379 2.07 0.194 0.365 0.594 0.226 1.21 0.601 2.55 PRS_PLINK_1.99526231496888e.08 FALSE 496.1 Emphysema Both 38 271 9 respiratory coral4 271, 38 42, 5 89, 15 48, 4 65, 10 -0.0733 0.221 0.74 0.13 0.929 0.599 1.45 0.174 0.525 0.74 0.131 1.19 0.439 3.66 -0.348 0.724 0.63 0.2 0.706 0.159 3.07 0.249 0.554 0.653 0.185 1.28 0.436 4.16 PRS_PLINK_1.99526231496888e.08 TRUE 496.2 Chronic bronchitis Both 80 477 9 respiratory coral4 477, 80 75, 10 165, 32 71, 10 118, 16 -0.211 0.151 0.164 0.785 0.81 0.593 1.08 0.36 0.383 0.346 0.461 1.43 0.696 3.17 0.0905 0.466 0.846 0.073 1.09 0.433 2.79 -0.0514 0.418 0.902 0.045 0.95 0.418 2.24 PRS_PLINK_1.99526231496888e.08 FALSE 496.21 Obstructive chronic bronchitis Both 63 426 9 respiratory coral4 426, 63 64, 7 108, 14 109, 16 102, 15 -0.214 0.169 0.206 0.686 0.807 0.568 1.12 0.194 0.483 0.688 0.163 1.21 0.475 3.36 0.235 0.488 0.63 0.201 1.26 0.497 3.5 0.17 0.48 0.723 0.141 1.19 0.467 3.24 PRS_PLINK_1.99526231496888e.08 FALSE 496.3 Bronchiectasis Both 19 87 9 respiratory coral4 87, 19 13, 3 28, 9 16, 0 21, 6 0.177 0.38 0.641 0.193 1.19 0.573 2.63 0.514 0.811 0.526 0.279 1.67 0.38 8.69 -0.507 1.41 0.719 0.143 0.602 0.000151 1040 1.9 1.27 0.134 0.873 6.66 0.751 169 PRS_PLINK_1.99526231496888e.08 TRUE 497 Bronchitis Both 118 446 9 respiratory coral4 446, 118 64, 18 112, 25 111, 34 111, 27 -0.121 0.115 0.291 0.537 0.886 0.694 1.09 -0.302 0.364 0.406 0.391 0.739 0.365 1.51 -0.0424 0.34 0.901 0.045 0.958 0.5 1.87 -0.225 0.352 0.523 0.281 0.799 0.404 1.6 PRS_PLINK_1.99526231496888e.08 FALSE 498 Acute bronchospasm Both 38 130 9 respiratory coral4 130, 38 18, 10 46, 9 18, 5 33, 9 -0.105 0.202 0.605 0.219 0.901 0.525 1.22 -0.795 0.574 0.166 0.78 0.452 0.15 1.32 -0.424 0.728 0.56 0.252 0.654 0.163 2.49 -0.548 0.597 0.359 0.445 0.578 0.184 1.77 PRS_PLINK_1.99526231496888e.08 TRUE 499 Cystic fibrosis Both 14 70 9 respiratory coral4 70, 14 12, 1 17, 7 17, 3 18, 2 -0.278 0.27 0.303 0.519 0.757 0.337 1.16 2.94 1.59 0.064 1.194 18.9 1.46 43100 1.19 1.31 0.363 0.441 3.3 0.28 135 -0.213 1.31 0.871 0.06 0.808 0.00185 7150 PRS_PLINK_1.99526231496888e.08 TRUE 500 Lung disease due to external agents Both 21 89 9 respiratory coral4 89, 21 11, 1 25, 7 19, 1 22, 10 0.423 0.345 0.221 0.656 1.53 0.786 3.12 0.741 0.96 0.441 0.356 2.1 0.398 21.1 -0.563 1.3 0.666 0.176 0.57 0.0109 9.58 1.92 1.13 0.0884 1.053 6.81 0.957 105 PRS_PLINK_1.99526231496888e.08 TRUE 500.1 Extrinsic allergic alveolitis Both 5 19 9 respiratory coral4 19, 5 1, 0 5, 2 4, 1 5, 2 0.543 0.855 0.526 0.279 1.72 0.367 12.3 0.136 1430 1 0 1.15 0.515 2.44 -0.97 6000 1 0 0.379 3.26e-08 15200000 -6e-14 10.2 1 0 1 2.46e-07 5120000 PRS_PLINK_1.99526231496888e.08 TRUE 500.2 Pneumoconiosis Both 1 8 9 respiratory coral4 8, 1 2, 1 2, 0 2, 0 2, 0 -1.04 372 0.998 0.001 0.353 0.00301 2.07 0.0382 13200 1 0 1.04 0.203 7.52 -0.838 10700 1 0 0.433 0.00369 12.8 0.177 3310 1 0 1.19 0.795 2 PRS_PLINK_1.99526231496888e.08 TRUE 501 Pneumonitis due to inhalation of food or vomitus Both 7 86 9 respiratory coral4 86, 7 15, 2 31, 2 11, 0 22, 1 -0.673 0.502 0.18 0.746 0.51 0.138 1.23 -0.728 0.964 0.45 0.347 0.483 0.0583 3.67 -0.0683 1.48 0.963 0.016 0.934 0.00659 83.3 -0.721 1.1 0.514 0.289 0.486 0.00032 5.16 PRS_PLINK_1.99526231496888e.08 TRUE 502 Postinflammatory pulmonary fibrosis Both 27 149 9 respiratory coral4 149, 27 19, 6 49, 10 25, 5 37, 3 -0.33 0.264 0.212 0.674 0.719 0.422 1.24 -0.574 0.657 0.382 0.418 0.563 0.155 1.99 -0.546 0.733 0.456 0.341 0.579 0.136 2.32 -1.24 0.832 0.135 0.869 0.289 0.0446 1.35 PRS_PLINK_1.99526231496888e.08 TRUE 503 Pulmonary congestion and hypostasis Both 23 145 9 respiratory coral4 145, 23 29, 5 46, 11 26, 4 36, 1 -0.521 0.298 0.0805 1.094 0.594 0.323 1.09 0.0473 0.6 0.937 0.028 1.05 0.328 3.54 -0.244 0.736 0.741 0.13 0.784 0.162 3.42 -1.43 1.03 0.164 0.786 0.239 0.0137 1.83 PRS_PLINK_1.99526231496888e.08 TRUE 504 Other alveolar and parietoalveolar pneumonopathy Both 15 93 9 respiratory coral4 93, 15 10, 3 28, 8 18, 3 23, 0 -0.345 0.342 0.314 0.503 0.709 0.353 1.38 -0.254 0.84 0.763 0.118 0.776 0.15 3.95 -0.707 1.12 0.528 0.278 0.493 0.0523 4.62 -2.89 1.68 0.0849 1.071 0.0554 9.66e-07 1.03 PRS_PLINK_1.99526231496888e.08 TRUE 504.1 Idiopathic fibrosing alveolitis Both 6 47 9 respiratory coral4 47, 6 9, 2 11, 2 11, 1 12, 0 -0.449 0.495 0.364 0.438 0.638 0.22 1.7 1 1.42 0.48 0.318 2.73 0.17 666 -0.541 1.34 0.685 0.164 0.582 0.0156 15900 -1.08 1.43 0.449 0.348 0.338 0.00825 4.95 PRS_PLINK_1.99526231496888e.08 TRUE 505 Other pulmonary inflamation or edema Both 46 268 9 respiratory coral4 268, 46 37, 5 71, 17 63, 10 67, 10 -0.0179 0.212 0.933 0.03 0.982 0.647 1.5 0.393 0.561 0.484 0.315 1.48 0.516 4.77 0.121 0.597 0.839 0.076 1.13 0.35 3.9 0.151 0.573 0.792 0.101 1.16 0.38 3.88 PRS_PLINK_1.99526231496888e.08 TRUE 506 Empyema and pneumothorax Both 54 482 9 respiratory coral4 482, 54 70, 5 165, 22 76, 11 120, 11 0.116 0.114 0.311 0.507 1.12 0.869 1.37 0.472 0.483 0.328 0.484 1.6 0.645 4.68 0.559 0.528 0.29 0.538 1.75 0.628 5.44 0.139 0.513 0.787 0.104 1.15 0.414 3.55 PRS_PLINK_1.99526231496888e.08 FALSE 507 Pleurisy; pleural effusion Both 83 569 9 respiratory coral4 569, 83 83, 5 153, 23 131, 20 142, 26 0.0795 0.112 0.476 0.323 1.08 0.853 1.32 0.986 0.515 0.0557 1.254 2.68 1.01 8.46 0.873 0.48 0.0693 1.159 2.39 0.958 6.98 1.06 0.477 0.0259 1.587 2.9 1.18 8.45 PRS_PLINK_1.99526231496888e.08 FALSE 508 Pulmonary collapse; interstitial and compensatory emphysema Both 72 458 9 respiratory coral4 458, 72 71, 9 160, 25 68, 13 114, 16 -0.137 0.163 0.402 0.396 0.872 0.625 1.2 0.106 0.411 0.797 0.099 1.11 0.506 2.61 0.391 0.45 0.385 0.415 1.48 0.608 3.72 0.109 0.444 0.806 0.094 1.12 0.467 2.78 PRS_PLINK_1.99526231496888e.08 FALSE 509 Respiratory failure, insufficiency, arrest Both 83 604 9 respiratory coral4 604, 83 89, 14 202, 31 97, 19 151, 12 -0.0974 0.133 0.464 0.334 0.907 0.68 1.16 0.0449 0.347 0.897 0.047 1.05 0.537 2.12 0.201 0.374 0.591 0.229 1.22 0.588 2.59 -0.553 0.405 0.171 0.766 0.575 0.252 1.3 PRS_PLINK_1.99526231496888e.08 FALSE 509.1 Respiratory failure Both 43 349 9 respiratory coral4 349, 43 54, 6 122, 19 51, 9 87, 5 -0.255 0.213 0.23 0.638 0.775 0.503 1.19 0.267 0.487 0.584 0.234 1.31 0.517 3.69 0.314 0.557 0.572 0.242 1.37 0.452 4.32 -0.478 0.607 0.431 0.366 0.62 0.172 2.17 PRS_PLINK_1.99526231496888e.08 TRUE 509.2 Respiratory insufficiency Both 30 207 9 respiratory coral4 207, 30 36, 4 67, 13 34, 5 52, 5 -0.111 0.222 0.616 0.211 0.895 0.523 1.31 0.737 0.61 0.227 0.645 2.09 0.666 7.84 0.51 0.727 0.483 0.316 1.67 0.404 7.98 0.354 0.713 0.619 0.208 1.43 0.321 6.59 PRS_PLINK_1.99526231496888e.08 TRUE 509.3 Pulmonary insufficiency or respiratory failure following trauma and surgery Both 32 264 9 respiratory coral4 264, 32 33, 4 91, 13 40, 8 66, 5 0.0467 0.232 0.84 0.076 1.05 0.657 1.67 0.231 0.582 0.691 0.16 1.26 0.422 4.47 0.645 0.687 0.348 0.459 1.91 0.516 8.33 -0.171 0.749 0.819 0.087 0.842 0.167 4.08 PRS_PLINK_1.99526231496888e.08 TRUE 509.8 Dependence on respirator [Ventilator] or supplemental oxygen Both 35 289 9 respiratory coral4 289, 35 45, 4 105, 14 40, 6 70, 4 -0.39 0.235 0.0969 1.014 0.677 0.42 1.08 0.522 0.579 0.368 0.434 1.68 0.565 5.98 0.511 0.688 0.458 0.339 1.67 0.43 7.45 0.167 0.685 0.807 0.093 1.18 0.282 5.3 PRS_PLINK_1.99526231496888e.08 TRUE 510 Other diseases of lung Both 211 810 9 respiratory coral4 810, 211 120, 32 269, 79 132, 28 202, 53 -0.0749 0.0925 0.418 0.379 0.928 0.767 1.1 0.0599 0.245 0.807 0.093 1.06 0.662 1.73 -0.236 0.291 0.417 0.38 0.79 0.445 1.39 -0.0565 0.258 0.827 0.083 0.945 0.573 1.57 PRS_PLINK_1.99526231496888e.08 FALSE 510.2 Lung transplant Both 8 24 9 respiratory coral4 24, 8 2, 0 7, 5 5, 1 6, 1 -0.698 0.646 0.28 0.553 0.497 0.102 1.58 1.23 2.49 0.622 0.206 3.42 0.104 1010 0.685 1400000 1 0 1.98 0.399 9.28 0.0575 254000 1 0 1.06 0.988 1.09 PRS_PLINK_1.99526231496888e.08 TRUE 512 Other symptoms of respiratory system Both 804 465 9 respiratory coral4 465, 804 70, 126 143, 267 87, 139 116, 187 -0.0267 0.059 0.651 0.186 0.974 0.869 1.09 -0.048 0.189 0.799 0.097 0.953 0.658 1.37 -0.175 0.212 0.409 0.388 0.84 0.555 1.27 -0.216 0.201 0.283 0.549 0.806 0.544 1.19 PRS_PLINK_1.99526231496888e.08 FALSE 512.1 Wheezing Both 97 200 9 respiratory coral4 200, 97 34, 19 62, 28 38, 20 50, 15 -0.373 0.164 0.0233 1.633 0.689 0.496 0.942 -0.252 0.398 0.526 0.279 0.777 0.364 1.67 -0.0311 0.449 0.945 0.025 0.969 0.413 2.28 -0.611 0.43 0.156 0.807 0.543 0.236 1.22 PRS_PLINK_1.99526231496888e.08 FALSE 512.2 Painful respiration Both 167 365 9 respiratory coral4 365, 167 53, 28 114, 54 67, 22 90, 45 0.0113 0.0975 0.908 0.042 1.01 0.829 1.21 -0.173 0.304 0.568 0.246 0.841 0.47 1.51 -0.447 0.372 0.229 0.64 0.64 0.309 1.31 -0.15 0.316 0.634 0.198 0.861 0.469 1.59 PRS_PLINK_1.99526231496888e.08 FALSE 512.3 Abnormal chest sounds Both 17 27 9 respiratory coral4 27, 17 8, 4 8, 6 4, 2 7, 3 0.0122 0.676 0.986 0.006 1.01 0.254 3.59 0.485 1.3 0.709 0.149 1.62 0.182 20 5.24 3.75 0.162 0.79 188 0.73 1.97e+08 -0.418 1.61 0.795 0.1 0.659 0.0214 30.6 PRS_PLINK_1.99526231496888e.08 TRUE 512.7 Shortness of breath Both 468 465 9 respiratory coral4 465, 468 70, 62 143, 170 87, 80 116, 106 -0.0452 0.0688 0.511 0.291 0.956 0.833 1.09 0.234 0.222 0.292 0.534 1.26 0.821 1.95 0.0334 0.261 0.898 0.047 1.03 0.624 1.72 0.00988 0.24 0.967 0.014 1.01 0.634 1.61 PRS_PLINK_1.99526231496888e.08 FALSE 512.8 Cough Both 541 465 9 respiratory coral4 465, 541 70, 89 143, 185 87, 87 116, 124 0.00604 0.0627 0.923 0.035 1.01 0.891 1.14 -0.0586 0.205 0.776 0.11 0.943 0.632 1.4 -0.281 0.236 0.233 0.633 0.755 0.477 1.19 -0.206 0.219 0.346 0.461 0.814 0.531 1.24 PRS_PLINK_1.99526231496888e.08 FALSE 512.9 Other dyspnea Both 464 465 9 respiratory coral4 465, 464 70, 72 143, 151 87, 82 116, 106 -0.0492 0.0733 0.502 0.299 0.952 0.823 1.1 -0.0541 0.219 0.805 0.094 0.947 0.619 1.45 -0.1 0.251 0.689 0.162 0.904 0.556 1.47 -0.157 0.235 0.503 0.298 0.855 0.541 1.35 PRS_PLINK_1.99526231496888e.08 FALSE 513 Respiratory abnormalities Both 530 739 9 respiratory coral4 739, 530 107, 71 245, 183 124, 84 185, 136 0.0237 0.0583 0.684 0.165 1.02 0.913 1.15 0.0384 0.19 0.84 0.076 1.04 0.719 1.51 -0.0044 0.226 0.984 0.007 0.996 0.641 1.55 0.044 0.201 0.827 0.083 1.04 0.708 1.55 PRS_PLINK_1.99526231496888e.08 FALSE 513.3 Hypoventilation Both 48 149 9 respiratory coral4 149, 48 26, 12 57, 16 17, 1 37, 14 -0.0346 0.191 0.856 0.067 0.966 0.647 1.36 -0.688 0.485 0.156 0.807 0.503 0.197 1.26 -1.6 0.932 0.0861 1.065 0.202 0.0182 1.01 -0.238 0.501 0.634 0.198 0.788 0.305 2.03 PRS_PLINK_1.99526231496888e.08 TRUE 513.31 Apnea Both 25 80 9 respiratory coral4 80, 25 12, 5 28, 9 12, 0 20, 8 -0.0759 0.238 0.75 0.125 0.927 0.534 1.37 -0.324 0.759 0.669 0.174 0.723 0.177 3.07 -1.02 1.24 0.411 0.386 0.361 0.000572 3 -0.0375 0.736 0.959 0.018 0.963 0.255 3.74 PRS_PLINK_1.99526231496888e.08 TRUE 513.32 Orthopnea Both 12 23 9 respiratory coral4 23, 12 6, 3 10, 5 1, 0 6, 3 -0.0291 0.568 0.959 0.018 0.971 0.347 2.71 0.37 1.06 0.728 0.138 1.45 0.242 11.6 0.679 5.02 0.892 0.049 1.97 0.000848 2.58 -0.116 1.2 0.923 0.035 0.89 0.111 7.18 PRS_PLINK_1.99526231496888e.08 TRUE 513.4 Hyperventilation Both 19 86 9 respiratory coral4 86, 19 15, 3 21, 2 21, 2 22, 10 0.318 0.362 0.38 0.42 1.37 0.694 2.84 -0.444 0.884 0.615 0.211 0.641 0.0976 3.93 -0.82 0.977 0.402 0.396 0.441 0.0468 2.82 0.364 0.758 0.631 0.2 1.44 0.351 6.88 PRS_PLINK_1.99526231496888e.08 TRUE 513.8 Disorders of diaphragm Both 9 35 9 respiratory coral4 35, 9 5, 3 10, 1 7, 2 9, 3 0.0957 0.358 0.789 0.103 1.1 0.444 2.01 -0.799 1.88 0.671 0.173 0.45 0.00418 82.2 0.892 1.67 0.592 0.228 2.44 0.139 164 -0.534 1.19 0.655 0.184 0.586 0.0646 5.15 PRS_PLINK_1.99526231496888e.08 TRUE 514 Abnormal findings examination of lungs Both 151 811 9 respiratory coral4 811, 151 128, 33 267, 45 134, 18 202, 38 -0.141 0.106 0.184 0.734 0.868 0.696 1.06 -0.435 0.259 0.0926 1.033 0.647 0.391 1.08 -0.674 0.317 0.0334 1.477 0.51 0.268 0.942 -0.298 0.268 0.266 0.575 0.742 0.438 1.26 PRS_PLINK_1.99526231496888e.08 FALSE 514.1 Abnormal results of function study of pulmonary system Both 10 44 9 respiratory coral4 44, 10 3, 3 11, 3 11, 4 11, 0 0.121 0.483 0.802 0.096 1.13 0.453 3.02 -2.72 2.27 0.232 0.635 0.0661 3.74e-05 3.31 -0.363 1.62 0.822 0.085 0.696 0.0287 11.9 -2.86 2.24 0.202 0.694 0.0575 2.63e-05 1.91 PRS_PLINK_1.99526231496888e.08 TRUE 514.2 Solitary pulmonary nodule Both 87 539 9 respiratory coral4 539, 87 79, 14 189, 29 81, 6 133, 26 -0.0849 0.138 0.54 0.268 0.919 0.685 1.19 -0.0706 0.37 0.849 0.071 0.932 0.458 1.97 -0.959 0.501 0.0558 1.253 0.383 0.131 1.01 0.0631 0.368 0.864 0.064 1.07 0.521 2.24 PRS_PLINK_1.99526231496888e.08 FALSE 516 Abnormal sputum Both 24 162 9 respiratory coral4 162, 24 24, 2 41, 8 39, 7 41, 5 -0.0628 0.243 0.796 0.099 0.939 0.55 1.46 0.773 0.841 0.358 0.447 2.17 0.465 15.3 0.38 0.747 0.611 0.214 1.46 0.359 7.84 0.199 0.773 0.797 0.099 1.22 0.272 6.96 PRS_PLINK_1.99526231496888e.08 TRUE 516.1 Hemoptysis Both 22 143 9 respiratory coral4 143, 22 20, 1 39, 8 32, 6 36, 5 -0.0594 0.245 0.808 0.092 0.942 0.543 1.46 1.03 0.948 0.276 0.559 2.81 0.493 32.4 0.809 0.855 0.344 0.463 2.24 0.462 19.7 0.275 0.905 0.761 0.118 1.32 0.239 12.4 PRS_PLINK_1.99526231496888e.08 TRUE 519 Other diseases of respiratory system, not elsewhere classified Both 231 1004 9 respiratory coral4 1004, 231 151, 20 330, 92 176, 36 247, 53 -0.0189 0.0769 0.806 0.094 0.981 0.835 1.13 0.692 0.267 0.00962 2.017 2 1.2 3.46 0.441 0.3 0.142 0.848 1.55 0.867 2.85 0.425 0.283 0.132 0.878 1.53 0.887 2.72 PRS_PLINK_1.99526231496888e.08 FALSE 519.1 Tracheostomy complications Both 0 27 9 respiratory coral4 27, 0 5 10 4 6 PRS_PLINK_1.99526231496888e.08 TRUE 519.2 Respiratory complications Both 7 71 9 respiratory coral4 71, 7 6, 1 21, 2 14, 2 18, 0 -1.7 0.746 0.0226 1.647 0.182 0.0124 0.75 -0.122 1.56 0.938 0.028 0.885 0.0449 19.8 0.105 1.92 0.956 0.019 1.11 0.00241 68.5 -3.33 2.79 0.233 0.633 0.0358 2.02e-06 3.66 PRS_PLINK_1.99526231496888e.08 TRUE 519.8 Other diseases of respiratory system, NEC Both 63 366 9 respiratory coral4 366, 63 59, 3 115, 22 67, 14 91, 17 0.0644 0.107 0.548 0.261 1.07 0.842 1.29 1.23 0.591 0.0371 1.43 3.43 1.16 13.6 1.21 0.604 0.046 1.337 3.34 1.08 13.3 1.14 0.608 0.0604 1.219 3.13 0.999 12.7 PRS_PLINK_1.99526231496888e.08 FALSE 519.9 Symptoms involving respiratory system and other chest symptoms Both 160 800 9 respiratory coral4 800, 160 124, 15 269, 69 129, 22 199, 35 0.0323 0.0906 0.722 0.142 1.03 0.854 1.22 0.717 0.304 0.0184 1.735 2.05 1.15 3.85 0.314 0.352 0.373 0.429 1.37 0.685 2.79 0.268 0.327 0.412 0.385 1.31 0.694 2.56 PRS_PLINK_1.99526231496888e.08 FALSE 520 Disorders of tooth development Both 8 99 10 digestive chartreuse4 99, 8 16, 2 29, 2 20, 1 25, 2 -0.364 0.466 0.435 0.362 0.695 0.247 1.89 -0.761 0.953 0.424 0.372 0.467 0.0479 3.71 -0.313 1.26 0.804 0.095 0.731 0.0581 24.9 -0.693 0.938 0.46 0.337 0.5 0.0574 3.53 PRS_PLINK_1.99526231496888e.08 TRUE 520.1 Hereditary disturbances in tooth structure Both 3 48 10 digestive chartreuse4 48, 3 6, 2 13, 0 11, 0 12, 1 0.0473 0.596 0.937 0.028 1.05 0.293 4.68 -0.899 1.65 0.585 0.233 0.407 0.00161 294 -1.86 1.79 0.299 0.524 0.156 0.00085 3.97 -1.38 1.57 0.377 0.424 0.25 0.000383 3 PRS_PLINK_1.99526231496888e.08 TRUE 520.2 Disturbances in tooth eruption Both 5 56 10 digestive chartreuse4 56, 5 9, 0 19, 2 9, 1 14, 1 0.379 0.638 0.553 0.258 1.46 0.37 6.17 0.55 1.34 0.682 0.167 1.73 0.15 4640 1.47 1.76 0.404 0.394 4.36 0.249 6160 0.956 1.88 0.612 0.213 2.6 0.0824 152000 PRS_PLINK_1.99526231496888e.08 TRUE 521 Diseases of hard tissues of teeth Both 22 228 10 digestive chartreuse4 228, 22 35, 1 79, 6 35, 5 57, 7 0.448 0.208 0.0311 1.507 1.57 1.09 2.51 0.888 0.844 0.292 0.534 2.43 0.488 24.1 1.57 0.936 0.0933 1.03 4.81 0.812 62 1.43 0.894 0.109 0.961 4.18 0.782 49.9 PRS_PLINK_1.99526231496888e.08 TRUE 521.1 Dental caries Both 18 219 10 digestive chartreuse4 219, 18 34, 0 77, 5 33, 2 54, 9 0.569 0.231 0.0139 1.857 1.77 1.2 3.26 1.34 1.03 0.196 0.707 3.8 0.546 386 1.53 1.16 0.187 0.727 4.62 0.42 287 2.96 1.54 0.0553 1.257 19.3 1.57 57100 PRS_PLINK_1.99526231496888e.08 TRUE 521.2 Dental abrasion, erosion and attrition Both 3 15 10 digestive chartreuse4 15, 3 2, 1 4, 1 3, 0 4, 1 0.938 1.65 0.57 0.244 2.55 0.0626 48300 -0.404 272 0.999 0.001 0.668 0.0577 5.98 -0.157 476 1 0 0.854 0.00354 1940 1.23 27.4 0.964 0.016 3.43 0.663 18.7 PRS_PLINK_1.99526231496888e.08 TRUE 522 Diseases of pulp and periapical tissues Both 30 171 10 digestive chartreuse4 171, 30 26, 3 49, 6 36, 6 43, 12 0.415 0.277 0.134 0.872 1.51 0.883 2.69 0.107 0.744 0.885 0.053 1.11 0.259 5.9 0.349 0.84 0.678 0.169 1.42 0.259 9.88 1.27 0.785 0.106 0.976 3.56 0.854 25.5 PRS_PLINK_1.99526231496888e.08 TRUE 522.5 Periapical abscess Both 28 143 10 digestive chartreuse4 143, 28 21, 2 36, 5 34, 6 36, 12 0.469 0.294 0.111 0.956 1.6 0.906 2.92 0.393 0.805 0.625 0.204 1.48 0.321 9.24 0.879 0.977 0.368 0.434 2.41 0.389 29.8 1.42 0.898 0.115 0.94 4.12 0.855 35.4 PRS_PLINK_1.99526231496888e.08 TRUE 523 Gingival and periodontal diseases Both 31 178 10 digestive chartreuse4 178, 31 32, 3 54, 6 33, 5 45, 11 0.122 0.13 0.346 0.461 1.13 0.864 1.42 0.445 0.791 0.574 0.241 1.56 0.323 9.59 0.124 0.909 0.891 0.05 1.13 0.161 8.01 1.02 0.676 0.131 0.884 2.78 0.797 12.3 PRS_PLINK_1.99526231496888e.08 TRUE 523.1 Gingivitis Both 5 36 10 digestive chartreuse4 36, 5 7, 0 13, 0 5, 1 9, 3 0.261 0.672 0.698 0.156 1.3 0.348 6.02 1.12 2.24 0.618 0.209 3.07 0.0993 647 5.5 4.1 0.18 0.745 244 0.315 13300000 PRS_PLINK_1.99526231496888e.08 TRUE 523.3 Periodontitis (acute or chronic) Both 17 100 10 digestive chartreuse4 100, 17 19, 1 32, 5 19, 1 24, 7 0.0818 0.362 0.821 0.085 1.09 0.538 2.27 0.451 1.26 0.719 0.143 1.57 0.0379 66.2 0.386 1.35 0.775 0.111 1.47 0.0442 6790 1.27 0.957 0.184 0.735 3.56 0.666 37.7 PRS_PLINK_1.99526231496888e.08 TRUE 523.31 Acute periodontitis Both 16 82 10 digestive chartreuse4 82, 16 14, 1 25, 5 15, 2 21, 5 0.0451 0.186 0.808 0.093 1.05 0.579 1.37 0.694 1.42 0.626 0.203 2 0.098 90.9 -0.881 1.54 0.567 0.246 0.414 0.00185 10.2 2.61 1.69 0.123 0.91 13.6 0.864 8030 PRS_PLINK_1.99526231496888e.08 TRUE 523.32 Chronic periodontitis Both 2 19 10 digestive chartreuse4 19, 2 5, 0 7, 0 2, 0 5, 1 -1.07 1.15 0.353 0.452 0.343 0.0034 2.37 0.0655 2.72 0.981 0.008 1.07 0.00481 1400 PRS_PLINK_1.99526231496888e.08 TRUE 524 Dentofacial anomalies, including malocclusion Both 9 116 10 digestive chartreuse4 116, 9 23, 0 35, 3 23, 1 29, 3 0.182 0.262 0.487 0.313 1.2 0.744 1.99 1.9 1.25 0.128 0.894 6.69 0.688 846 -0.0926 1.43 0.949 0.023 0.912 0.0026 25.3 1.28 1.35 0.343 0.465 3.58 0.259 747 PRS_PLINK_1.99526231496888e.08 TRUE 524.3 Anomalies of tooth position/malocclusion Both 5 60 10 digestive chartreuse4 60, 5 8, 0 19, 3 11, 1 15, 0 -0.918 0.586 0.117 0.931 0.399 0.0849 1.29 1.07 1.47 0.464 0.334 2.93 0.249 370 0.0745 2.1 0.972 0.012 1.08 0.00511 1740 PRS_PLINK_1.99526231496888e.08 TRUE 525 Other diseases of the teeth and supporting structures Both 30 303 10 digestive chartreuse4 303, 30 48, 2 106, 11 48, 4 73, 8 -0.0686 0.248 0.782 0.107 0.934 0.567 1.55 0.573 0.681 0.401 0.397 1.77 0.49 9.32 -0.683 1.01 0.499 0.302 0.505 0.0271 14.3 0.85 0.682 0.213 0.672 2.34 0.63 12.3 PRS_PLINK_1.99526231496888e.08 TRUE 525.1 Loss of teeth or edentulism Both 14 94 10 digestive chartreuse4 94, 14 14, 4 26, 4 20, 2 24, 2 -0.287 0.378 0.448 0.349 0.75 0.349 1.58 -1.03 1 0.305 0.516 0.357 0.0426 2.27 -0.946 1.08 0.379 0.421 0.388 0.0228 2.82 -0.396 0.98 0.686 0.164 0.673 0.0951 4.61 PRS_PLINK_1.99526231496888e.08 TRUE 526 Diseases of the jaws Both 136 824 10 digestive chartreuse4 824, 136 117, 20 287, 45 125, 14 205, 45 0.12 0.0916 0.191 0.72 1.13 0.935 1.34 -0.246 0.296 0.406 0.392 0.782 0.44 1.42 -0.49 0.374 0.19 0.721 0.613 0.286 1.27 0.306 0.301 0.31 0.509 1.36 0.76 2.49 PRS_PLINK_1.99526231496888e.08 FALSE 526.1 Cysts of the jaws Both 5 61 10 digestive chartreuse4 61, 5 10, 0 21, 1 8, 1 15, 3 0.0759 0.186 0.683 0.166 1.08 0.715 1.45 -0.622 1.47 0.672 0.173 0.537 0.00678 39.1 0.448 1.35 0.74 0.131 1.56 0.088 24.8 2.42 1.94 0.21 0.677 11.3 0.31 15500 PRS_PLINK_1.99526231496888e.08 TRUE 526.3 Anomalies of jaw size/symmetry Both 8 67 10 digestive chartreuse4 67, 8 11, 0 21, 2 12, 2 17, 3 0.0246 0.466 0.958 0.019 1.02 0.404 2.8 1.51 1.79 0.399 0.399 4.52 0.165 89200000 0.251 1.49 0.866 0.063 1.29 0.0127 137 1.61 1.36 0.236 0.627 4.99 0.422 525 PRS_PLINK_1.99526231496888e.08 TRUE 526.4 Temporomandibular joint disorders Both 95 535 10 digestive chartreuse4 535, 95 77, 10 186, 33 81, 11 133, 33 0.222 0.136 0.102 0.99 1.25 0.962 1.64 0.124 0.401 0.757 0.121 1.13 0.526 2.6 -0.107 0.503 0.832 0.08 0.899 0.32 2.5 0.787 0.42 0.0608 1.216 2.2 0.995 5.22 PRS_PLINK_1.99526231496888e.08 FALSE 526.41 Temporomandibular joint disorder, unspecified Both 81 447 10 digestive chartreuse4 447, 81 63, 8 159, 31 65, 11 111, 23 0.077 0.162 0.635 0.197 1.08 0.784 1.49 0.224 0.43 0.603 0.22 1.25 0.553 3.08 0.0702 0.524 0.893 0.049 1.07 0.371 3.14 0.611 0.469 0.193 0.715 1.84 0.756 4.9 PRS_PLINK_1.99526231496888e.08 FALSE 526.42 Arthralgia/ankylosis of temporomandibular joint Both 38 285 10 digestive chartreuse4 285, 38 43, 5 107, 12 35, 4 71, 16 0.468 0.223 0.0354 1.451 1.6 1.07 2.6 -0.279 0.587 0.634 0.198 0.756 0.239 2.66 -0.187 0.677 0.782 0.107 0.829 0.182 3.32 0.612 0.58 0.291 0.536 1.84 0.622 6.16 PRS_PLINK_1.99526231496888e.08 TRUE 526.5 Inflammatory conditions of jaw Both 3 58 10 digestive chartreuse4 58, 3 10, 0 19, 1 9, 0 15, 2 0.504 0.716 0.482 0.317 1.65 0.366 17.7 0.141 1.37 0.918 0.037 1.15 0.0534 226 0.308 1.38 0.824 0.084 1.36 0.0707 62.9 PRS_PLINK_1.99526231496888e.08 TRUE 526.8 Exostosis of jaw Both 1 9 10 digestive chartreuse4 9, 1 2, 1 2, 0 2, 0 2, 0 0.245 1780 1 0 1.28 0.453 3.46 0.0486 27600 1 0 1.05 0.0851 5.26 0.0129 900 1 0 1.01 0.66 1.59 0.251 27700 1 0 1.29 0.00645 1.34 PRS_PLINK_1.99526231496888e.08 TRUE 526.9 Jaw disease NOS Both 19 120 10 digestive chartreuse4 120, 19 17, 4 32, 2 28, 4 30, 8 0.226 0.228 0.32 0.494 1.25 0.731 1.83 -1.08 0.866 0.215 0.668 0.341 0.0442 1.87 -0.516 0.789 0.513 0.29 0.597 0.121 2.8 -0.702 0.887 0.428 0.368 0.495 0.0619 2.7 PRS_PLINK_1.99526231496888e.08 TRUE 527 Diseases of the salivary glands Both 66 400 10 digestive chartreuse4 400, 66 62, 12 99, 17 100, 10 100, 18 -0.0719 0.153 0.638 0.195 0.931 0.669 1.23 -0.293 0.42 0.486 0.314 0.746 0.327 1.73 -0.941 0.468 0.0445 1.351 0.39 0.151 0.975 -0.0172 0.416 0.967 0.015 0.983 0.437 2.27 PRS_PLINK_1.99526231496888e.08 FALSE 527.1 Hypertrophy of salivary gland Both 2 14 10 digestive chartreuse4 14, 2 2, 0 3, 0 3, 0 4, 2 0.757 1.19 0.524 0.28 2.13 0.341 50.4 -1.51 3e+06 1 0 0.222 0.0167 54.8 PRS_PLINK_1.99526231496888e.08 TRUE 527.2 Sialoadenitis Both 23 102 10 digestive chartreuse4 102, 23 15, 6 25, 2 25, 4 26, 7 -0.141 0.302 0.64 0.194 0.868 0.473 1.57 -1.74 0.961 0.0703 1.153 0.176 0.0152 1 -1.72 0.916 0.0609 1.215 0.18 0.0238 0.914 -0.399 0.724 0.582 0.235 0.671 0.166 2.69 PRS_PLINK_1.99526231496888e.08 TRUE 527.7 Disturbance of salivary secretion Both 26 202 10 digestive chartreuse4 202, 26 33, 5 70, 5 30, 4 51, 8 0.0045 0.223 0.984 0.007 1 0.606 1.49 -0.516 0.645 0.424 0.373 0.597 0.159 2.27 -0.232 0.816 0.776 0.11 0.793 0.128 4.16 0.421 0.654 0.52 0.284 1.52 0.432 6.05 PRS_PLINK_1.99526231496888e.08 TRUE 527.8 Other specified diseases of the salivary glands Both 9 51 10 digestive chartreuse4 51, 9 8, 2 13, 4 11, 1 13, 2 0.00764 0.307 0.98 0.009 1.01 0.33 1.88 -0.523 1.2 0.663 0.178 0.593 0.0419 8.8 -0.841 1.26 0.506 0.296 0.431 0.0261 3.77 -0.349 1.2 0.77 0.113 0.705 0.0564 7.65 PRS_PLINK_1.99526231496888e.08 TRUE 528 Diseases of the oral soft tissues, excluding lesions specific for gingiva and tongue Both 118 649 10 digestive chartreuse4 649, 118 101, 18 235, 33 85, 15 161, 40 0.144 0.0799 0.0721 1.142 1.15 0.987 1.34 -0.334 0.316 0.29 0.538 0.716 0.386 1.36 -0.0865 0.376 0.818 0.087 0.917 0.433 1.92 0.293 0.312 0.348 0.459 1.34 0.736 2.52 PRS_PLINK_1.99526231496888e.08 FALSE 528.1 Stomatitis and mucositis Both 40 183 10 digestive chartreuse4 183, 40 26, 4 54, 10 38, 9 45, 14 0.186 0.129 0.15 0.823 1.2 0.958 1.57 -0.085 0.625 0.892 0.05 0.919 0.28 3.41 0.399 0.664 0.548 0.261 1.49 0.432 5.92 0.646 0.595 0.278 0.557 1.91 0.628 6.7 PRS_PLINK_1.99526231496888e.08 TRUE 528.11 Stomatitis and mucositis (ulcerative) Both 13 56 10 digestive chartreuse4 56, 13 8, 1 15, 2 13, 3 14, 6 0.165 0.151 0.275 0.56 1.18 0.922 1.62 -1.13 1.4 0.418 0.379 0.322 0.00874 4.22 0.466 1.24 0.708 0.15 1.59 0.134 24.3 0.829 1.24 0.504 0.298 2.29 0.218 30.7 PRS_PLINK_1.99526231496888e.08 TRUE 528.12 Oral aphthae Both 15 82 10 digestive chartreuse4 82, 15 12, 2 24, 3 17, 5 20, 4 -0.222 0.395 0.575 0.24 0.801 0.349 1.8 -0.393 1.02 0.7 0.155 0.675 0.0729 4.97 0.227 1.06 0.83 0.081 1.25 0.132 12.4 -0.595 1.1 0.589 0.23 0.552 0.0529 4.3 PRS_PLINK_1.99526231496888e.08 TRUE 528.3 Cellulitis and abscess of oral soft tissues Both 12 58 10 digestive chartreuse4 58, 12 12, 2 19, 4 9, 0 15, 6 1.34 0.637 0.0349 1.457 3.84 1.21 16.8 -0.149 0.98 0.879 0.056 0.861 0.124 6.46 -2.24 1.81 0.215 0.668 0.106 0.000401 3.17 0.584 0.955 0.541 0.267 1.79 0.336 12.5 PRS_PLINK_1.99526231496888e.08 TRUE 528.4 Cysts of oral soft tissues Both 3 26 10 digestive chartreuse4 26, 3 3, 0 9, 0 3, 1 7, 2 0.785 0.804 0.329 0.482 2.19 0.537 53.9 -0.0384 74.6 1 0 0.962 0.835 1.23 0.32 1.8 0.859 0.066 1.38 0.0867 202 PRS_PLINK_1.99526231496888e.08 TRUE 528.41 Cyst of the salivary gland Both 1 18 10 digestive chartreuse4 18, 1 3, 0 6, 0 2, 1 5, 0 -0.337 1.1 0.76 0.119 0.714 0.000466 12.5 -0.149 3420 1 0 0.862 0.82 1.62 PRS_PLINK_1.99526231496888e.08 TRUE 528.5 Diseases of lips Both 30 125 10 digestive chartreuse4 125, 30 24, 3 40, 10 21, 4 30, 8 0.0077 0.27 0.977 0.01 1.01 0.597 1.71 0.497 0.753 0.51 0.293 1.64 0.398 8.03 0.159 0.843 0.851 0.07 1.17 0.228 6.58 0.425 0.73 0.56 0.252 1.53 0.377 7.01 PRS_PLINK_1.99526231496888e.08 TRUE 528.6 Leukoplakia of oral mucosa Both 1 26 10 digestive chartreuse4 26, 1 3, 0 6, 0 6, 1 7, 0 0.746 0.792 0.347 0.46 2.11 0.483 38.7 1.51 2.59 0.561 0.251 4.53 0.188 1050 PRS_PLINK_1.99526231496888e.08 TRUE 528.7 Sialolithiasis Both 8 40 10 digestive chartreuse4 40, 8 6, 2 10, 2 10, 0 10, 4 0.23 0.562 0.682 0.166 1.26 0.328 4.16 0.369 1.41 0.793 0.101 1.45 0.117 76.1 -0.777 1.63 0.635 0.197 0.46 0.011 9.42 0.504 1.25 0.688 0.162 1.65 0.13 19.7 PRS_PLINK_1.99526231496888e.08 TRUE 529 Diseases and other conditions of the tongue Both 29 146 10 digestive chartreuse4 146, 29 32, 4 42, 10 26, 3 37, 8 -0.319 0.282 0.259 0.587 0.727 0.406 1.25 0.572 0.654 0.382 0.418 1.77 0.515 7.19 -0.459 0.809 0.57 0.244 0.632 0.103 3.09 0.238 0.669 0.721 0.142 1.27 0.34 5.11 PRS_PLINK_1.99526231496888e.08 TRUE 529.1 Glossitis Both 7 35 10 digestive chartreuse4 35, 7 6, 1 11, 3 6, 1 9, 1 -0.244 0.667 0.714 0.146 0.783 0.185 3.09 2.1 2.14 0.327 0.486 8.17 0.00558 628000 2.37 3.41 0.488 0.312 10.6 0.0696 195000 0.337 1.7 0.843 0.074 1.4 0.00244 603 PRS_PLINK_1.99526231496888e.08 TRUE 529.6 Glossodynia Both 7 40 10 digestive chartreuse4 40, 7 6, 3 12, 1 8, 2 10, 1 0.00158 0.371 0.997 0.001 1 0.263 1.84 -1.59 1.51 0.291 0.536 0.204 0.00547 2.13 -1.26 1.48 0.392 0.406 0.283 0.00101 3 -1.09 1.92 0.569 0.245 0.335 5.31e-05 12 PRS_PLINK_1.99526231496888e.08 TRUE 530 Diseases of esophagus Both 611 621 10 digestive chartreuse4 621, 611 93, 74 209, 213 103, 103 153, 154 0.00259 0.0579 0.964 0.016 1 0.895 1.12 0.149 0.194 0.443 0.354 1.16 0.796 1.69 0.234 0.216 0.278 0.555 1.26 0.833 1.92 0.173 0.2 0.385 0.414 1.19 0.808 1.75 PRS_PLINK_1.99526231496888e.08 FALSE 530.1 Esophagitis, GERD and related diseases Both 603 621 10 digestive chartreuse4 621, 603 93, 73 209, 210 103, 102 153, 151 0.0036 0.0579 0.95 0.022 1 0.896 1.12 0.143 0.195 0.463 0.334 1.15 0.79 1.69 0.24 0.216 0.268 0.573 1.27 0.837 1.94 0.174 0.2 0.384 0.416 1.19 0.808 1.76 PRS_PLINK_1.99526231496888e.08 FALSE 530.11 GERD Both 589 621 10 digestive chartreuse4 621, 589 93, 71 209, 205 103, 98 153, 150 0.00722 0.0581 0.901 0.045 1.01 0.899 1.13 0.149 0.196 0.448 0.349 1.16 0.793 1.7 0.233 0.219 0.286 0.543 1.26 0.828 1.93 0.202 0.202 0.316 0.5 1.22 0.828 1.81 PRS_PLINK_1.99526231496888e.08 FALSE 530.12 Ulcer of esophagus Both 11 70 10 digestive chartreuse4 70, 11 10, 3 22, 4 12, 1 18, 1 -0.606 0.422 0.151 0.822 0.545 0.192 1.16 -0.914 0.989 0.355 0.45 0.401 0.0501 2.55 -1.42 1.27 0.265 0.577 0.242 0.00587 1.99 -1.54 1.14 0.175 0.756 0.214 0.0093 1.83 PRS_PLINK_1.99526231496888e.08 TRUE 530.13 Barrett's esophagus Both 24 83 10 digestive chartreuse4 83, 24 13, 1 21, 6 20, 6 21, 5 -0.463 0.336 0.168 0.774 0.629 0.325 1.19 0.396 0.997 0.692 0.16 1.49 0.241 13.7 1.14 1.18 0.338 0.472 3.11 0.412 75.2 0.601 1.03 0.558 0.253 1.82 0.262 24.2 PRS_PLINK_1.99526231496888e.08 TRUE 530.14 Reflux esophagitis Both 108 342 10 digestive chartreuse4 342, 108 55, 15 119, 39 51, 15 86, 26 -0.0799 0.136 0.556 0.255 0.923 0.695 1.19 0.156 0.368 0.672 0.172 1.17 0.581 2.43 0.153 0.42 0.715 0.146 1.17 0.514 2.66 -0.0302 0.393 0.939 0.027 0.97 0.455 2.11 PRS_PLINK_1.99526231496888e.08 FALSE 530.15 Eosinophilic esophagitis Both 18 65 10 digestive chartreuse4 65, 18 14, 1 16, 4 15, 6 16, 6 0.384 0.439 0.382 0.418 1.47 0.642 3.59 1.08 1.17 0.358 0.446 2.94 0.374 76.2 1.71 1.29 0.187 0.729 5.52 0.617 106 0.559 1.14 0.625 0.204 1.75 0.208 21.8 PRS_PLINK_1.99526231496888e.08 TRUE 530.2 Esophageal bleeding (varices/hemorrhage) Both 14 100 10 digestive chartreuse4 100, 14 17, 0 24, 2 25, 6 25, 5 0.59 0.409 0.149 0.827 1.8 0.816 4.31 0.135 1.37 0.921 0.036 1.15 0.00352 72.9 2.54 1.53 0.0979 1.009 12.7 0.742 1920 1.86 1.36 0.17 0.768 6.41 0.531 802 PRS_PLINK_1.99526231496888e.08 TRUE 530.3 Stricture and stenosis of esophagus Both 33 137 10 digestive chartreuse4 137, 33 17, 4 35, 7 34, 9 33, 10 0.0882 0.176 0.617 0.21 1.09 0.795 1.56 -0.418 0.769 0.587 0.231 0.659 0.15 2.98 0.307 0.755 0.684 0.165 1.36 0.338 6.42 0.0345 0.821 0.967 0.015 1.04 0.216 5.5 PRS_PLINK_1.99526231496888e.08 TRUE 530.5 Disorders of esophageal motility Both 24 108 10 digestive chartreuse4 108, 24 14, 1 31, 6 24, 3 26, 9 0.142 0.159 0.373 0.428 1.15 0.833 1.52 0.531 1.12 0.637 0.196 1.7 0.197 35 -0.0391 1.18 0.973 0.012 0.962 0.0773 14.8 1.45 1.05 0.17 0.769 4.25 0.731 60.1 PRS_PLINK_1.99526231496888e.08 TRUE 530.6 Diverticulum of esophagus, acquired Both 0 8 10 digestive chartreuse4 8, 0 3 1 2 2 PRS_PLINK_1.99526231496888e.08 TRUE 530.7 Gastroesophageal laceration-hemorrhage syndrome Both 3 20 10 digestive chartreuse4 20, 3 4, 0 5, 2 5, 0 5, 1 0.359 1.01 0.723 0.141 1.43 0.12 1850 -1.63 4.7 0.73 0.137 0.197 0.000445 200 0.102 3.33 0.975 0.011 1.11 0.00421 334 PRS_PLINK_1.99526231496888e.08 TRUE 530.9 Heartburn Both 85 346 10 digestive chartreuse4 346, 85 50, 12 91, 26 80, 12 87, 21 -0.164 0.153 0.286 0.544 0.849 0.622 1.14 0.238 0.409 0.56 0.251 1.27 0.584 2.89 -0.63 0.462 0.172 0.764 0.533 0.212 1.32 0.193 0.436 0.658 0.182 1.21 0.526 2.96 PRS_PLINK_1.99526231496888e.08 FALSE 531 Peptic ulcer (excl. esophageal) Both 84 489 10 digestive chartreuse4 489, 84 67, 7 123, 16 122, 24 121, 28 0.125 0.119 0.293 0.532 1.13 0.898 1.42 -0.26 0.494 0.599 0.223 0.771 0.288 2.16 0.536 0.441 0.224 0.65 1.71 0.741 4.36 0.714 0.447 0.11 0.957 2.04 0.881 5.26 PRS_PLINK_1.99526231496888e.08 FALSE 531.1 Hemorrhage from gastrointestinal ulcer Both 13 66 10 digestive chartreuse4 66, 13 12, 0 17, 5 15, 5 17, 3 -0.122 0.434 0.779 0.109 0.885 0.379 2.14 1.19 1.22 0.331 0.48 3.28 0.354 285 1.92 1.32 0.147 0.834 6.84 0.73 717 0.947 1.62 0.56 0.252 2.58 0.0488 568 PRS_PLINK_1.99526231496888e.08 TRUE 531.2 Gastric ulcer Both 48 278 10 digestive chartreuse4 278, 48 32, 5 77, 9 62, 13 69, 17 0.139 0.141 0.326 0.487 1.15 0.882 1.52 -0.688 0.671 0.305 0.515 0.502 0.127 2.03 0.202 0.588 0.731 0.136 1.22 0.409 4.12 0.448 0.594 0.45 0.347 1.57 0.516 5.46 PRS_PLINK_1.99526231496888e.08 TRUE 531.3 Duodenal ulcer Both 15 98 10 digestive chartreuse4 98, 15 11, 1 25, 3 23, 6 25, 3 0.303 0.219 0.167 0.777 1.35 0.902 2.05 -0.135 1.26 0.914 0.039 0.873 0.0492 14.3 0.772 1.12 0.491 0.309 2.16 0.282 47.7 -0.952 1.28 0.459 0.339 0.386 0.000462 19.5 PRS_PLINK_1.99526231496888e.08 TRUE 531.4 Peptic ulcer, site unspecified Both 39 204 10 digestive chartreuse4 204, 39 28, 3 51, 4 51, 12 51, 16 0.278 0.234 0.234 0.631 1.32 0.84 2.12 -1.39 0.974 0.154 0.812 0.25 0.0247 1.82 0.794 0.687 0.248 0.606 2.21 0.616 9.71 0.916 0.677 0.176 0.755 2.5 0.718 10.9 PRS_PLINK_1.99526231496888e.08 TRUE 531.5 Gastrojejunal ulcer Both 4 43 10 digestive chartreuse4 43, 4 3, 0 11, 0 10, 2 11, 2 0.441 0.717 0.538 0.269 1.55 0.389 7.09 1.34 6.28 0.831 0.08 3.81 3.64e-06 4.96e+08 -0.106 2.06 0.959 0.018 0.899 0.00111 146 PRS_PLINK_1.99526231496888e.08 TRUE 532 Dysphagia Both 195 602 10 digestive chartreuse4 602, 195 91, 29 210, 69 91, 33 150, 46 0.0129 0.0855 0.88 0.055 1.01 0.846 1.18 -0.0405 0.271 0.881 0.055 0.96 0.57 1.64 -0.0179 0.312 0.954 0.02 0.982 0.535 1.8 -0.122 0.283 0.668 0.175 0.886 0.512 1.54 PRS_PLINK_1.99526231496888e.08 FALSE 535 Gastritis and duodenitis Both 137 652 10 digestive chartreuse4 652, 137 98, 20 225, 48 102, 19 159, 40 0.0618 0.0823 0.452 0.344 1.06 0.893 1.23 0.0773 0.298 0.795 0.099 1.08 0.61 1.97 -0.0807 0.355 0.82 0.086 0.922 0.457 1.86 0.258 0.31 0.405 0.393 1.29 0.713 2.41 PRS_PLINK_1.99526231496888e.08 FALSE 535.1 Acute gastritis Both 52 263 10 digestive chartreuse4 263, 52 40, 5 94, 16 36, 7 65, 20 0.208 0.138 0.13 0.886 1.23 0.959 1.63 0.201 0.513 0.695 0.158 1.22 0.464 3.68 0.581 0.614 0.344 0.463 1.79 0.543 6.28 0.893 0.54 0.0983 1.008 2.44 0.895 7.74 PRS_PLINK_1.99526231496888e.08 FALSE 535.2 Atrophic gastritis Both 18 88 10 digestive chartreuse4 88, 18 13, 3 22, 1 22, 8 22, 5 0.183 0.193 0.344 0.463 1.2 0.81 1.97 -0.945 1.04 0.363 0.44 0.389 0.0275 3.03 0.451 0.852 0.597 0.224 1.57 0.326 10.4 -0.269 1.02 0.792 0.102 0.764 0.0978 6.93 PRS_PLINK_1.99526231496888e.08 TRUE 535.6 Duodenitis Both 17 58 10 digestive chartreuse4 58, 17 11, 2 13, 1 14, 6 15, 6 0.206 0.25 0.409 0.388 1.23 0.826 2.36 1.12 1.49 0.452 0.345 3.06 0.216 123 1.94 1.36 0.153 0.815 6.96 0.688 1330 0.255 0.946 0.788 0.104 1.29 0.235 9.64 PRS_PLINK_1.99526231496888e.08 TRUE 535.8 Other specified gastritis Both 29 159 10 digestive chartreuse4 159, 29 23, 6 52, 12 25, 2 40, 8 0.134 0.186 0.472 0.326 1.14 0.812 1.66 -0.199 0.589 0.735 0.134 0.819 0.269 2.62 -1.07 0.821 0.19 0.721 0.341 0.0548 1.52 -0.0571 0.65 0.93 0.031 0.945 0.274 3.42 PRS_PLINK_1.99526231496888e.08 TRUE 535.9 Gastritis and duodenitis, NOS Both 74 341 10 digestive chartreuse4 341, 74 49, 12 90, 19 79, 16 85, 21 0.0908 0.0956 0.342 0.466 1.1 0.896 1.3 -0.115 0.428 0.789 0.103 0.892 0.39 2.12 -0.173 0.438 0.693 0.159 0.841 0.359 2.02 -0.0698 0.411 0.865 0.063 0.933 0.423 2.12 PRS_PLINK_1.99526231496888e.08 FALSE 536 Disorders of function of stomach Both 184 707 10 digestive chartreuse4 707, 184 110, 38 235, 52 113, 20 176, 56 0.0174 0.0765 0.82 0.086 1.02 0.867 1.17 -0.448 0.248 0.0714 1.146 0.639 0.394 1.04 -0.652 0.307 0.034 1.469 0.521 0.281 0.944 -0.107 0.248 0.665 0.177 0.898 0.555 1.46 PRS_PLINK_1.99526231496888e.08 FALSE 536.3 Gastroparesis Both 38 228 10 digestive chartreuse4 228, 38 39, 6 61, 9 53, 9 57, 12 0.0729 0.148 0.622 0.206 1.08 0.746 1.38 -0.545 0.607 0.37 0.432 0.58 0.172 1.95 -0.365 0.647 0.572 0.242 0.694 0.176 2.57 0.139 0.53 0.792 0.101 1.15 0.413 3.41 PRS_PLINK_1.99526231496888e.08 TRUE 536.7 Complications of gastrostomy, colostomy and enterostomy Both 12 77 10 digestive chartreuse4 77, 12 13, 2 27, 5 11, 2 19, 2 -0.0949 0.359 0.792 0.101 0.909 0.4 1.8 -0.126 1.05 0.905 0.043 0.882 0.104 10.6 0.527 1.44 0.716 0.145 1.69 0.126 4600 0.461 1.31 0.726 0.139 1.58 0.136 28.2 PRS_PLINK_1.99526231496888e.08 TRUE 536.8 Dyspepsia and other specified disorders of function of stomach Both 161 553 10 digestive chartreuse4 553, 161 91, 33 190, 43 82, 18 138, 52 0.0391 0.0774 0.613 0.212 1.04 0.885 1.2 -0.52 0.269 0.0535 1.272 0.595 0.352 1.01 -0.416 0.336 0.216 0.666 0.66 0.337 1.26 0.0164 0.266 0.951 0.022 1.02 0.608 1.71 PRS_PLINK_1.99526231496888e.08 FALSE 537 Other disorders of stomach and duodenum Both 167 692 10 digestive chartreuse4 692, 167 104, 25 238, 56 107, 20 172, 48 0.0249 0.085 0.769 0.114 1.03 0.859 1.2 -0.106 0.269 0.693 0.159 0.899 0.534 1.54 -0.297 0.334 0.374 0.427 0.743 0.381 1.43 0.0668 0.278 0.81 0.091 1.07 0.625 1.86 PRS_PLINK_1.99526231496888e.08 FALSE 537.1 Lesions of stomach and duodenum Both 3 23 10 digestive chartreuse4 23, 3 0.742 0.851 0.383 0.416 2.1 0.49 14.5 PRS_PLINK_1.99526231496888e.08 TRUE 539 Bariatric surgery Both 83 556 10 digestive chartreuse4 556, 83 86, 12 199, 20 78, 16 139, 26 0.0883 0.108 0.414 0.383 1.09 0.865 1.33 -0.325 0.378 0.391 0.408 0.723 0.344 1.57 0.558 0.418 0.182 0.741 1.75 0.773 4.09 0.281 0.382 0.462 0.335 1.32 0.634 2.91 PRS_PLINK_1.99526231496888e.08 FALSE 540 Appendiceal conditions Both 26 155 10 digestive chartreuse4 155, 26 23, 3 39, 9 38, 3 39, 6 0.14 0.176 0.425 0.371 1.15 0.817 1.6 0.426 0.683 0.533 0.273 1.53 0.425 6.75 -1.22 0.882 0.168 0.775 0.297 0.0254 1.75 -0.123 0.721 0.864 0.063 0.884 0.204 4.14 PRS_PLINK_1.99526231496888e.08 TRUE 540.1 Appendicitis Both 23 135 10 digestive chartreuse4 135, 23 17, 2 35, 8 33, 3 33, 6 0.192 0.183 0.294 0.532 1.21 0.857 1.71 0.486 0.786 0.537 0.27 1.63 0.376 9.29 -0.823 0.931 0.377 0.424 0.439 0.046 3.56 0.0373 0.838 0.964 0.016 1.04 0.197 6.42 PRS_PLINK_1.99526231496888e.08 TRUE 540.11 Acute appendicitis Both 19 115 10 digestive chartreuse4 115, 19 14, 2 29, 8 29, 2 28, 4 -0.119 0.277 0.667 0.176 0.888 0.494 1.49 0.565 0.816 0.489 0.311 1.76 0.388 10.4 -3.18 1.85 0.0858 1.066 0.0417 5.48e-07 1.27 -0.219 0.832 0.792 0.101 0.803 0.143 4.67 PRS_PLINK_1.99526231496888e.08 TRUE 550 Abdominal hernia Both 209 949 10 digestive chartreuse4 949, 209 149, 28 321, 60 154, 34 236, 56 0.039 0.0756 0.606 0.217 1.04 0.887 1.19 -0.0643 0.255 0.801 0.096 0.938 0.573 1.56 0.199 0.283 0.483 0.316 1.22 0.702 2.14 0.112 0.257 0.664 0.178 1.12 0.679 1.87 PRS_PLINK_1.99526231496888e.08 FALSE 550.1 Inguinal hernia Both 43 213 10 digestive chartreuse4 213, 43 43, 4 57, 15 47, 4 53, 11 -0.236 0.226 0.298 0.526 0.79 0.507 1.23 0.971 0.572 0.0898 1.047 2.64 0.904 9.25 -0.0192 0.729 0.979 0.009 0.981 0.198 4.69 0.76 0.597 0.203 0.693 2.14 0.681 7.77 PRS_PLINK_1.99526231496888e.08 TRUE 550.2 Diaphragmatic hernia Both 98 573 10 digestive chartreuse4 573, 98 84, 9 152, 21 138, 28 139, 26 0.0457 0.126 0.717 0.145 1.05 0.806 1.33 0.295 0.409 0.47 0.328 1.34 0.61 3.16 0.563 0.402 0.161 0.792 1.76 0.814 4.09 0.411 0.409 0.315 0.501 1.51 0.685 3.56 PRS_PLINK_1.99526231496888e.08 FALSE 550.3 Femoral hernia Both 4 29 10 digestive chartreuse4 29, 4 4, 0 7, 0 7, 1 7, 1 -0.975 0.797 0.222 0.654 0.377 0.00715 1.48 -0.743 2.09 0.722 0.142 0.476 0.000187 13.5 0.048 1.9 0.98 0.009 1.05 0.017 43.7 PRS_PLINK_1.99526231496888e.08 TRUE 550.4 Umbilical hernia Both 57 260 10 digestive chartreuse4 260, 57 38, 5 64, 7 65, 23 65, 14 -0.00846 0.143 0.953 0.021 0.992 0.701 1.26 -0.255 0.614 0.678 0.169 0.775 0.221 2.78 0.83 0.536 0.122 0.915 2.29 0.851 7.15 0.462 0.559 0.409 0.388 1.59 0.552 5.12 PRS_PLINK_1.99526231496888e.08 FALSE 550.5 Ventral hernia Both 57 476 10 digestive chartreuse4 476, 57 79, 11 153, 15 81, 11 119, 12 -0.00161 0.127 0.99 0.004 0.998 0.732 1.24 -0.358 0.4 0.371 0.43 0.699 0.316 1.59 -0.0905 0.446 0.839 0.076 0.913 0.37 2.24 -0.416 0.428 0.332 0.479 0.66 0.278 1.57 PRS_PLINK_1.99526231496888e.08 FALSE 550.6 Incisional hernia Both 34 295 10 digestive chartreuse4 295, 34 47, 5 88, 10 61, 6 72, 8 -0.219 0.228 0.336 0.473 0.804 0.488 1.22 -0.0231 0.544 0.966 0.015 0.977 0.332 3.13 -0.138 0.613 0.822 0.085 0.871 0.24 3.19 -0.115 0.566 0.839 0.076 0.892 0.286 2.94 PRS_PLINK_1.99526231496888e.08 TRUE 555 Inflammatory bowel disease and other gastroenteritis and colitis Both 72 323 10 digestive chartreuse4 323, 72 56, 18 101, 27 59, 4 81, 13 -0.385 0.176 0.0284 1.547 0.68 0.479 0.954 -0.308 0.375 0.411 0.386 0.735 0.356 1.53 -1.5 0.549 0.00638 2.195 0.224 0.0662 0.625 -0.532 0.411 0.196 0.709 0.587 0.26 1.3 PRS_PLINK_1.99526231496888e.08 FALSE 555.1 Regional enteritis Both 42 187 10 digestive chartreuse4 187, 42 31, 13 54, 12 40, 3 46, 9 -0.353 0.225 0.116 0.937 0.702 0.444 1.08 -1.01 0.506 0.0461 1.336 0.365 0.13 0.954 -1.56 0.64 0.015 1.824 0.211 0.0502 0.691 -0.941 0.523 0.0722 1.141 0.39 0.139 1.03 PRS_PLINK_1.99526231496888e.08 TRUE 555.2 Ulcerative colitis Both 48 197 10 digestive chartreuse4 197, 48 30, 11 66, 20 32, 3 49, 7 -0.395 0.216 0.0678 1.169 0.674 0.433 1.01 -0.0679 0.475 0.886 0.052 0.934 0.382 2.39 -1.38 0.666 0.0384 1.416 0.252 0.0595 0.846 -0.756 0.552 0.171 0.768 0.469 0.157 1.35 PRS_PLINK_1.99526231496888e.08 TRUE 555.21 Ulcerative colitis (chronic) Both 33 122 10 digestive chartreuse4 122, 33 15, 5 32, 10 29, 8 30, 4 -0.239 0.266 0.368 0.434 0.787 0.466 1.32 -0.107 0.678 0.875 0.058 0.899 0.254 3.38 -0.309 0.671 0.646 0.19 0.735 0.215 2.63 -0.69 0.812 0.396 0.403 0.501 0.0969 2.38 PRS_PLINK_1.99526231496888e.08 TRUE 556 Ulceration of the lower GI tract Both 25 71 10 digestive chartreuse4 71, 25 9, 2 24, 13 11, 0 18, 6 -0.0604 0.315 0.848 0.072 0.941 0.518 1.71 0.929 0.981 0.344 0.464 2.53 0.441 22.5 -0.611 1.45 0.675 0.171 0.543 0.00696 14.8 -0.19 1.11 0.865 0.063 0.827 0.0962 6.77 PRS_PLINK_1.99526231496888e.08 TRUE 556.1 Ulceration of intestine Both 25 61 10 digestive chartreuse4 61, 25 7, 2 23, 13 7, 0 15, 6 -0.0569 0.329 0.863 0.064 0.945 0.508 1.75 1.06 1.02 0.297 0.527 2.88 0.489 27.4 -0.441 1.82 0.809 0.092 0.643 0.0165 22.6 -0.207 1.23 0.866 0.062 0.813 0.0663 7.43 PRS_PLINK_1.99526231496888e.08 TRUE 556.11 Angiodysplasia of intestine (without mention of hemorrhage) Both 6 17 10 digestive chartreuse4 17, 6 6, 0 5, 3 2, 0 4, 2 -0.423 1.04 0.683 0.166 0.655 0.0436 4.46 0.0247 384 1 0 1.02 0.857 1.12 5.55 10.2 0.586 0.232 256 8.99e-05 348 PRS_PLINK_1.99526231496888e.08 TRUE 557 Intestinal malabsorption (non-celiac) Both 118 439 10 digestive chartreuse4 439, 118 70, 18 141, 33 75, 16 110, 34 0.0208 0.104 0.841 0.075 1.02 0.826 1.24 -0.0703 0.348 0.84 0.076 0.932 0.477 1.87 -0.0581 0.399 0.884 0.053 0.944 0.433 2.06 0.251 0.344 0.465 0.333 1.29 0.666 2.55 PRS_PLINK_1.99526231496888e.08 FALSE 557.1 Celiac disease Both 35 125 10 digestive chartreuse4 125, 35 22, 5 39, 11 22, 3 31, 11 -0.0411 0.269 0.879 0.056 0.96 0.569 1.62 0.262 0.699 0.708 0.15 1.3 0.342 5.54 0.302 0.896 0.736 0.133 1.35 0.234 9.92 0.566 0.721 0.432 0.364 1.76 0.465 7.52 PRS_PLINK_1.99526231496888e.08 TRUE 558 Noninfectious gastroenteritis Both 200 550 10 digestive chartreuse4 550, 200 86, 26 177, 70 98, 31 137, 40 -0.191 0.103 0.0641 1.193 0.826 0.672 1.01 0.176 0.273 0.519 0.284 1.19 0.706 2.05 0.0785 0.315 0.803 0.095 1.08 0.587 2.01 -0.0638 0.291 0.827 0.083 0.938 0.533 1.67 PRS_PLINK_1.99526231496888e.08 FALSE 559 Ileostomy status Both 27 163 10 digestive chartreuse4 163, 27 23, 6 63, 11 18, 2 41, 5 -0.251 0.269 0.35 0.457 0.778 0.439 1.28 -0.398 0.609 0.513 0.29 0.671 0.214 2.31 -0.663 0.814 0.415 0.382 0.515 0.0883 2.26 -0.762 0.659 0.248 0.606 0.467 0.126 1.67 PRS_PLINK_1.99526231496888e.08 TRUE 560 Intestinal obstruction without mention of hernia Both 91 445 10 digestive chartreuse4 445, 91 71, 20 150, 30 73, 11 110, 19 -0.0232 0.125 0.853 0.069 0.977 0.741 1.22 -0.353 0.335 0.292 0.534 0.703 0.366 1.36 -0.447 0.413 0.28 0.553 0.64 0.278 1.42 -0.524 0.373 0.16 0.795 0.592 0.283 1.23 PRS_PLINK_1.99526231496888e.08 FALSE 560.1 Paralytic ileus Both 32 214 10 digestive chartreuse4 214, 32 35, 9 53, 6 53, 8 54, 5 -0.447 0.249 0.073 1.137 0.639 0.384 1.05 -0.952 0.587 0.105 0.98 0.386 0.115 1.2 -0.361 0.544 0.506 0.296 0.697 0.24 2.02 -0.799 0.602 0.184 0.735 0.45 0.129 1.44 PRS_PLINK_1.99526231496888e.08 TRUE 560.2 Impaction of intestine Both 32 86 10 digestive chartreuse4 86, 32 15, 7 25, 8 17, 10 22, 4 -0.257 0.29 0.375 0.426 0.773 0.439 1.34 -0.526 0.652 0.42 0.376 0.591 0.177 1.97 0.78 0.752 0.299 0.524 2.18 0.584 9.5 -0.878 0.821 0.285 0.546 0.416 0.0738 1.88 PRS_PLINK_1.99526231496888e.08 TRUE 560.3 Peritoneal or intestinal adhesions Both 8 43 10 digestive chartreuse4 43, 8 10, 1 10, 2 10, 0 11, 4 0.0427 0.535 0.936 0.029 1.04 0.366 3.28 1.01 2.21 0.647 0.189 2.75 0.0238 1430 -0.485 1.44 0.737 0.133 0.616 0.00157 10 1.27 1.28 0.319 0.496 3.56 0.384 93.8 PRS_PLINK_1.99526231496888e.08 TRUE 560.4 Other intestinal obstruction Both 48 262 10 digestive chartreuse4 262, 48 42, 11 66, 6 64, 12 66, 13 0.0854 0.14 0.542 0.266 1.09 0.802 1.39 -1.15 0.552 0.0376 1.425 0.317 0.0999 0.924 -0.307 0.466 0.51 0.292 0.736 0.296 1.85 -0.333 0.469 0.478 0.32 0.717 0.287 1.8 PRS_PLINK_1.99526231496888e.08 TRUE 561 Symptoms involving digestive system Both 138 483 10 digestive chartreuse4 483, 138 76, 18 153, 58 87, 17 120, 31 -0.00493 0.105 0.963 0.016 0.995 0.801 1.21 0.422 0.32 0.187 0.729 1.53 0.832 2.9 -0.0968 0.387 0.803 0.095 0.908 0.425 1.94 0.00997 0.337 0.976 0.01 1.01 0.526 1.98 PRS_PLINK_1.99526231496888e.08 FALSE 562 Diverticulosis and diverticulitis Both 211 371 10 digestive chartreuse4 371, 211 60, 26 96, 47 90, 62 92, 54 0.0676 0.109 0.536 0.271 1.07 0.861 1.32 0.02 0.323 0.951 0.022 1.02 0.547 1.92 0.194 0.328 0.554 0.257 1.21 0.645 2.3 0.156 0.319 0.624 0.205 1.17 0.633 2.18 PRS_PLINK_1.99526231496888e.08 FALSE 562.1 Diverticulosis Both 208 369 10 digestive chartreuse4 369, 208 60, 26 95, 45 90, 61 91, 54 0.0767 0.109 0.483 0.316 1.08 0.869 1.33 -0.0424 0.327 0.897 0.047 0.959 0.51 1.81 0.173 0.328 0.599 0.223 1.19 0.631 2.26 0.169 0.32 0.597 0.224 1.18 0.64 2.21 PRS_PLINK_1.99526231496888e.08 FALSE 562.2 Diverticulitis Both 45 179 10 digestive chartreuse4 179, 45 30, 9 59, 19 30, 6 45, 7 -0.198 0.226 0.381 0.419 0.82 0.525 1.28 0.0663 0.477 0.889 0.051 1.07 0.433 2.77 -0.546 0.634 0.389 0.41 0.579 0.159 1.96 -0.502 0.558 0.369 0.433 0.605 0.199 1.79 PRS_PLINK_1.99526231496888e.08 TRUE 564 Functional digestive disorders Both 497 565 10 digestive chartreuse4 565, 497 88, 62 181, 181 102, 78 140, 122 0.0575 0.0604 0.342 0.466 1.06 0.943 1.19 0.287 0.204 0.16 0.795 1.33 0.897 1.98 0.0609 0.233 0.794 0.1 1.06 0.677 1.67 0.147 0.214 0.49 0.31 1.16 0.766 1.76 PRS_PLINK_1.99526231496888e.08 FALSE 564.1 Irritable Bowel Syndrome Both 211 520 10 digestive chartreuse4 520, 211 82, 34 165, 69 92, 35 130, 54 0.0203 0.0862 0.814 0.089 1.02 0.859 1.2 -0.14 0.26 0.589 0.23 0.869 0.526 1.45 -0.101 0.301 0.736 0.133 0.904 0.504 1.62 -0.0449 0.269 0.867 0.062 0.956 0.569 1.62 PRS_PLINK_1.99526231496888e.08 FALSE 564.9 Personal history of diseases of digestive system Both 124 497 10 digestive chartreuse4 497, 124 80, 17 167, 33 82, 23 123, 37 0.191 0.111 0.0857 1.067 1.21 0.981 1.51 -0.0297 0.344 0.931 0.031 0.971 0.5 1.94 0.324 0.364 0.375 0.426 1.38 0.686 2.84 0.284 0.338 0.401 0.397 1.33 0.694 2.62 PRS_PLINK_1.99526231496888e.08 FALSE 565 Anal and rectal conditions Both 163 661 10 digestive chartreuse4 661, 163 91, 21 228, 55 104, 26 163, 46 0.0637 0.0829 0.443 0.354 1.07 0.895 1.24 0.0296 0.304 0.922 0.035 1.03 0.576 1.9 -0.0148 0.332 0.965 0.016 0.985 0.517 1.89 0.146 0.302 0.629 0.201 1.16 0.648 2.11 PRS_PLINK_1.99526231496888e.08 FALSE 565.1 Anal and rectal polyp Both 59 196 10 digestive chartreuse4 196, 59 31, 9 67, 15 31, 9 49, 22 0.128 0.117 0.275 0.561 1.14 0.895 1.4 -0.223 0.48 0.643 0.192 0.8 0.32 2.09 -0.14 0.551 0.799 0.097 0.869 0.301 2.46 0.39 0.482 0.418 0.378 1.48 0.599 3.86 PRS_PLINK_1.99526231496888e.08 FALSE 567 Peritonitis and retroperitoneal infections Both 46 237 10 digestive chartreuse4 237, 46 30, 10 61, 9 56, 13 58, 5 -0.414 0.211 0.0497 1.304 0.661 0.432 0.999 -0.657 0.5 0.188 0.725 0.518 0.195 1.37 -0.378 0.479 0.429 0.368 0.685 0.273 1.75 -1.37 0.606 0.024 1.62 0.255 0.0679 0.803 PRS_PLINK_1.99526231496888e.08 TRUE 568 Other disorders of peritoneum Both 44 324 10 digestive chartreuse4 324, 44 37, 3 89, 9 74, 16 80, 11 0.0276 0.144 0.848 0.072 1.03 0.704 1.3 0.266 0.667 0.69 0.161 1.3 0.365 5.85 0.666 0.614 0.278 0.556 1.95 0.615 7.89 0.802 0.702 0.253 0.597 2.23 0.591 10.9 PRS_PLINK_1.99526231496888e.08 TRUE 568.1 Peritoneal adhesions (postoperative) (postinfection) Both 28 226 10 digestive chartreuse4 226, 28 21, 2 65, 6 47, 10 57, 10 0.118 0.147 0.423 0.374 1.13 0.833 1.47 -0.0469 0.778 0.952 0.021 0.954 0.214 5.67 0.422 0.737 0.567 0.246 1.52 0.392 7.96 0.527 0.796 0.508 0.294 1.69 0.385 10.1 PRS_PLINK_1.99526231496888e.08 TRUE 569 Other disorders of intestine Both 333 819 10 digestive chartreuse4 819, 333 116, 42 272, 127 138, 54 204, 76 -0.0581 0.0728 0.425 0.372 0.944 0.812 1.08 0.163 0.223 0.465 0.333 1.18 0.766 1.83 0.0403 0.262 0.878 0.057 1.04 0.625 1.74 -0.0773 0.237 0.745 0.128 0.926 0.585 1.47 PRS_PLINK_1.99526231496888e.08 FALSE 569.1 Toxic gastroenteritis and colitis Both 18 83 10 digestive chartreuse4 83, 18 11, 2 22, 5 19, 7 21, 2 0.17 0.354 0.631 0.2 1.19 0.603 2.4 -0.513 0.984 0.602 0.22 0.599 0.0832 4.28 1.17 1.06 0.27 0.569 3.22 0.526 33.4 -0.846 1.2 0.479 0.32 0.429 0.0268 4.19 PRS_PLINK_1.99526231496888e.08 TRUE 569.2 Gastrointestinal complications Both 49 295 10 digestive chartreuse4 295, 49 37, 8 86, 13 61, 11 74, 11 -0.0887 0.147 0.545 0.264 0.915 0.629 1.16 -0.635 0.516 0.219 0.66 0.53 0.193 1.49 -0.165 0.498 0.741 0.13 0.848 0.32 2.31 -0.548 0.547 0.316 0.5 0.578 0.195 1.71 PRS_PLINK_1.99526231496888e.08 TRUE 571 Chronic liver disease and cirrhosis Both 179 727 10 digestive chartreuse4 727, 179 114, 26 236, 50 126, 32 180, 53 0.0997 0.0768 0.194 0.711 1.1 0.945 1.27 -0.104 0.276 0.707 0.15 0.902 0.529 1.56 0.144 0.298 0.629 0.201 1.15 0.648 2.07 0.245 0.273 0.37 0.432 1.28 0.755 2.2 PRS_PLINK_1.99526231496888e.08 FALSE 571.5 Other chronic nonalcoholic liver disease Both 173 710 10 digestive chartreuse4 710, 173 114, 24 233, 49 120, 31 177, 51 0.0991 0.0775 0.201 0.697 1.1 0.943 1.28 -0.0288 0.284 0.919 0.037 0.972 0.562 1.71 0.219 0.305 0.472 0.326 1.25 0.689 2.27 0.29 0.28 0.3 0.523 1.34 0.78 2.34 PRS_PLINK_1.99526231496888e.08 FALSE 571.51 Cirrhosis of liver without mention of alcohol Both 23 190 10 digestive chartreuse4 190, 23 30, 4 47, 4 47, 7 48, 7 0.217 0.197 0.271 0.567 1.24 0.735 1.73 -0.394 0.78 0.614 0.212 0.675 0.135 3.36 0.215 0.685 0.754 0.123 1.24 0.322 5.4 0.149 0.751 0.843 0.074 1.16 0.26 5.77 PRS_PLINK_1.99526231496888e.08 TRUE 571.6 Primary biliary cirrhosis Both 7 37 10 digestive chartreuse4 37, 7 5, 0 9, 0 8, 5 9, 2 0.479 0.621 0.44 0.357 1.61 0.512 6.28 1.25 2.51 0.619 0.208 3.49 0.0303 1040 0.441 2.23 0.843 0.074 1.55 0.00189 358 PRS_PLINK_1.99526231496888e.08 TRUE 571.8 Liver abscess and sequelae of chronic liver disease Both 20 168 10 digestive chartreuse4 168, 20 27, 3 44, 2 38, 7 42, 8 0.248 0.226 0.272 0.566 1.28 0.791 1.94 -0.436 0.827 0.598 0.223 0.647 0.102 3.61 0.551 0.768 0.473 0.325 1.74 0.383 9.51 0.459 0.706 0.515 0.288 1.58 0.422 7.48 PRS_PLINK_1.99526231496888e.08 TRUE 571.81 Portal hypertension Both 13 102 10 digestive chartreuse4 102, 13 15, 3 25, 1 24, 6 26, 3 -0.0959 0.372 0.796 0.099 0.909 0.433 1.94 -0.573 1.04 0.58 0.237 0.564 0.0505 4.22 0.299 0.835 0.72 0.142 1.35 0.279 7.16 -0.723 0.932 0.438 0.359 0.485 0.0618 3.09 PRS_PLINK_1.99526231496888e.08 TRUE 572 Ascites (non malignant) Both 77 456 10 digestive chartreuse4 456, 77 66, 8 142, 21 88, 18 111, 21 0.151 0.11 0.171 0.766 1.16 0.927 1.42 0.213 0.476 0.654 0.184 1.24 0.497 3.34 0.463 0.449 0.303 0.519 1.59 0.669 4.04 0.543 0.451 0.228 0.642 1.72 0.728 4.42 PRS_PLINK_1.99526231496888e.08 FALSE 573 Other disorders of liver Both 214 777 10 digestive chartreuse4 777, 214 118, 32 259, 68 130, 34 191, 60 0.0748 0.0729 0.305 0.516 1.08 0.929 1.23 -0.105 0.251 0.675 0.17 0.9 0.555 1.48 -0.0246 0.279 0.93 0.032 0.976 0.567 1.68 0.0377 0.255 0.882 0.054 1.04 0.635 1.72 PRS_PLINK_1.99526231496888e.08 FALSE 573.1 Chronic passive congestion of liver Both 3 23 10 digestive chartreuse4 23, 3 1, 0 6, 2 5, 0 6, 1 0.344 0.681 0.614 0.212 1.41 0.404 7.62 -1.8 7.4 0.808 0.092 0.166 0.143 0.196 1.22 62.8 0.985 0.007 3.38 0.0268 431 PRS_PLINK_1.99526231496888e.08 TRUE 573.2 Liver replaced by transplant Both 7 53 10 digestive chartreuse4 53, 7 9, 0 14, 2 12, 2 13, 3 1.4 0.708 0.0486 1.313 4.04 1.08 23.6 0.693 1.55 0.655 0.184 2 0.108 235 0.576 1.9 0.762 0.118 1.78 0.0417 1010 0.831 1.42 0.56 0.252 2.3 0.192 241 PRS_PLINK_1.99526231496888e.08 TRUE 573.3 Hepatomegaly Both 17 117 10 digestive chartreuse4 117, 17 17, 1 31, 5 27, 5 29, 6 0.152 0.16 0.344 0.463 1.16 0.855 1.55 1.88 1.28 0.141 0.851 6.54 0.624 443 0.992 0.975 0.309 0.511 2.7 0.465 35 2.16 1.34 0.109 0.963 8.64 0.798 630 PRS_PLINK_1.99526231496888e.08 TRUE 573.4 Acute and subacute necrosis of liver Both 6 63 10 digestive chartreuse4 63, 6 12, 0 20, 2 9, 2 16, 2 1.16 0.702 0.0999 1 3.18 0.813 32 1.6 1.66 0.333 0.478 4.98 0.199 4690 0.413 1.68 0.806 0.094 1.51 0.0109 122 1.65 1.58 0.296 0.528 5.2 0.262 161000 PRS_PLINK_1.99526231496888e.08 TRUE 573.5 Jaundice (not of newborn) Both 33 163 10 digestive chartreuse4 163, 33 21, 2 40, 9 40, 7 41, 9 0.0411 0.251 0.87 0.06 1.04 0.637 1.71 0.312 0.826 0.706 0.151 1.37 0.294 8.1 0.465 0.809 0.566 0.247 1.59 0.325 10.2 0.741 0.82 0.366 0.436 2.1 0.482 12.8 PRS_PLINK_1.99526231496888e.08 TRUE 573.6 Nonspecific elevation of levels of transaminase or lactic acid dehydrogenase [LDH] Both 140 512 10 digestive chartreuse4 512, 140 89, 24 164, 46 86, 25 128, 36 0.0469 0.1 0.639 0.194 1.05 0.852 1.26 -0.0344 0.29 0.906 0.043 0.966 0.552 1.72 -0.00474 0.333 0.989 0.005 0.995 0.52 1.9 -0.051 0.303 0.866 0.062 0.95 0.528 1.73 PRS_PLINK_1.99526231496888e.08 FALSE 573.7 Abnormal results of function study of liver Both 167 542 10 digestive chartreuse4 542, 167 82, 28 186, 55 86, 23 134, 47 0.00406 0.0885 0.963 0.016 1 0.835 1.18 -0.147 0.274 0.592 0.228 0.863 0.51 1.48 -0.234 0.331 0.479 0.32 0.791 0.413 1.5 0.0175 0.287 0.951 0.022 1.02 0.586 1.79 PRS_PLINK_1.99526231496888e.08 FALSE 573.9 Abnormal serum enzyme levels Both 218 775 10 digestive chartreuse4 775, 218 115, 29 256, 73 132, 42 192, 56 0.0816 0.0732 0.265 0.577 1.09 0.938 1.25 0.0534 0.251 0.831 0.08 1.05 0.651 1.74 0.241 0.279 0.388 0.411 1.27 0.741 2.21 0.0772 0.264 0.77 0.114 1.08 0.648 1.82 PRS_PLINK_1.99526231496888e.08 FALSE 574 Cholelithiasis and cholecystitis Both 157 839 10 digestive chartreuse4 839, 157 125, 15 281, 50 137, 30 210, 42 0.0381 0.088 0.665 0.177 1.04 0.866 1.22 0.29 0.309 0.348 0.458 1.34 0.739 2.54 0.61 0.335 0.069 1.161 1.84 0.962 3.65 0.398 0.32 0.214 0.67 1.49 0.804 2.88 PRS_PLINK_1.99526231496888e.08 FALSE 574.1 Cholelithiasis Both 148 806 10 digestive chartreuse4 806, 148 121, 13 273, 47 127, 23 202, 45 0.044 0.0893 0.622 0.206 1.05 0.868 1.23 0.355 0.327 0.277 0.557 1.43 0.764 2.82 0.54 0.362 0.136 0.866 1.72 0.846 3.61 0.664 0.332 0.0454 1.343 1.94 1.03 3.87 PRS_PLINK_1.99526231496888e.08 FALSE 574.11 Cholelithiasis with acute cholecystitis Both 22 90 10 digestive chartreuse4 90, 22 19, 4 34, 7 10, 2 23, 7 0.0155 0.194 0.937 0.028 1.02 0.603 1.38 0.0907 0.675 0.893 0.049 1.09 0.304 4.47 -0.144 1.1 0.896 0.048 0.866 0.0614 8.26 0.421 0.798 0.598 0.224 1.52 0.333 8.8 PRS_PLINK_1.99526231496888e.08 TRUE 574.12 Cholelithiasis with other cholecystitis Both 30 165 10 digestive chartreuse4 165, 30 29, 7 50, 13 32, 2 41, 8 -0.0577 0.297 0.846 0.073 0.944 0.527 1.71 -0.00769 0.528 0.988 0.005 0.992 0.357 2.84 -1.8 0.972 0.0635 1.197 0.165 0.0135 1.08 -0.18 0.6 0.764 0.117 0.835 0.252 2.73 PRS_PLINK_1.99526231496888e.08 TRUE 574.2 Calculus of bile duct Both 33 240 10 digestive chartreuse4 240, 33 42, 1 87, 11 33, 3 60, 9 -0.126 0.241 0.6 0.222 0.881 0.542 1.44 1.37 0.827 0.0965 1.016 3.95 0.833 37.7 0.976 0.88 0.267 0.573 2.66 0.433 23.7 1.19 0.803 0.138 0.861 3.29 0.725 29.7 PRS_PLINK_1.99526231496888e.08 TRUE 574.3 Cholecystitis without cholelithiasis Both 45 213 10 digestive chartreuse4 213, 45 32, 5 75, 17 32, 3 52, 14 -0.0224 0.16 0.888 0.051 0.978 0.668 1.28 0.287 0.547 0.6 0.222 1.33 0.474 4.27 -0.342 0.691 0.621 0.207 0.71 0.162 2.88 0.622 0.559 0.266 0.576 1.86 0.657 5.98 PRS_PLINK_1.99526231496888e.08 TRUE 575 Other biliary tract disease Both 118 593 10 digestive chartreuse4 593, 118 94, 10 195, 53 98, 18 148, 26 -0.0435 0.102 0.67 0.174 0.957 0.762 1.15 0.942 0.366 0.00997 2.001 2.57 1.29 5.56 0.491 0.403 0.223 0.652 1.63 0.742 3.77 0.279 0.386 0.469 0.329 1.32 0.625 2.97 PRS_PLINK_1.99526231496888e.08 FALSE 575.1 Cholangitis Both 6 80 10 digestive chartreuse4 80, 6 5, 0 22, 2 19, 2 19, 2 0.5 0.306 0.103 0.988 1.65 0.856 10.4 1.34 1.9 0.482 0.317 3.8 0.145 555 0.299 1.5 0.843 0.074 1.35 0.0796 257 -0.982 2.27 0.665 0.177 0.375 6.91e-05 4210 PRS_PLINK_1.99526231496888e.08 TRUE 575.2 Obstruction of bile duct Both 15 139 10 digestive chartreuse4 139, 15 20, 0 51, 8 18, 4 35, 1 -0.0284 0.228 0.901 0.045 0.972 0.38 1.34 2.16 1.43 0.13 0.886 8.65 0.732 7700 2.01 1.3 0.124 0.908 7.44 0.659 3110 0.275 1.27 0.829 0.081 1.32 0.0313 331 PRS_PLINK_1.99526231496888e.08 TRUE 575.6 Cholesterolosis of gallbladder Both 14 57 10 digestive chartreuse4 57, 14 9, 4 14, 3 14, 4 14, 3 -0.119 0.268 0.657 0.183 0.888 0.419 1.36 -1.68 1.39 0.228 0.643 0.186 0.00161 1.73 -0.702 0.963 0.466 0.332 0.495 0.0613 2.67 0.188 1.04 0.857 0.067 1.21 0.175 9.09 PRS_PLINK_1.99526231496888e.08 TRUE 575.7 Other disorders of gallbladder Both 65 267 10 digestive chartreuse4 267, 65 39, 6 67, 14 65, 15 67, 23 0.134 0.154 0.383 0.417 1.14 0.832 1.52 0.359 0.527 0.496 0.304 1.43 0.527 4.28 0.419 0.519 0.419 0.377 1.52 0.57 4.49 0.65 0.498 0.191 0.718 1.92 0.752 5.43 PRS_PLINK_1.99526231496888e.08 FALSE 575.8 Other disorders of biliary tract Both 40 272 10 digestive chartreuse4 272, 40 39, 1 67, 14 68, 12 68, 7 -0.143 0.181 0.429 0.367 0.867 0.548 1.17 1.66 0.804 0.0391 1.407 5.25 1.18 50.5 1.39 0.839 0.0986 1.006 4 0.824 39.8 0.779 0.825 0.345 0.462 2.18 0.445 20.3 PRS_PLINK_1.99526231496888e.08 TRUE 575.9 Nonspecific abnormal findings on radiological and other examination of biliary tract Both 11 61 10 digestive chartreuse4 61, 11 13, 2 18, 2 12, 4 15, 2 0.219 0.457 0.632 0.199 1.24 0.524 3.27 -0.348 1.32 0.792 0.101 0.706 0.0233 19.5 0.893 1.36 0.512 0.291 2.44 0.211 66.2 -0.704 1.25 0.574 0.241 0.494 0.034 4.95 PRS_PLINK_1.99526231496888e.08 TRUE 577 Diseases of pancreas Both 77 516 10 digestive chartreuse4 516, 77 82, 13 176, 31 81, 9 127, 19 0.0653 0.136 0.631 0.2 1.07 0.792 1.36 0.0841 0.356 0.813 0.09 1.09 0.548 2.25 -0.439 0.45 0.329 0.483 0.645 0.252 1.57 -0.0232 0.384 0.952 0.021 0.977 0.46 2.13 PRS_PLINK_1.99526231496888e.08 FALSE 577.1 Acute pancreatitis Both 44 317 10 digestive chartreuse4 317, 44 48, 8 104, 18 55, 5 77, 11 0.0293 0.181 0.871 0.06 1.03 0.685 1.43 -0.0939 0.465 0.84 0.076 0.91 0.37 2.37 -0.656 0.593 0.268 0.571 0.519 0.15 1.66 -0.242 0.481 0.616 0.211 0.785 0.302 2.1 PRS_PLINK_1.99526231496888e.08 TRUE 577.2 Chronic pancreatitis Both 17 120 10 digestive chartreuse4 120, 17 13, 2 30, 5 30, 5 30, 4 0.11 0.336 0.744 0.128 1.12 0.572 2.23 0.498 0.911 0.585 0.233 1.65 0.309 13.7 -0.121 0.869 0.889 0.051 0.886 0.142 5.4 -0.0807 0.83 0.923 0.035 0.922 0.187 5.7 PRS_PLINK_1.99526231496888e.08 TRUE 577.3 Cyst and pseudocyst of pancreas Both 20 119 10 digestive chartreuse4 119, 20 20, 4 40, 6 19, 4 29, 3 0.0491 0.242 0.839 0.076 1.05 0.514 1.55 -0.247 0.723 0.732 0.135 0.781 0.192 3.37 -0.00182 0.811 0.998 0.001 0.998 0.212 4.78 -0.325 0.777 0.676 0.17 0.723 0.145 3.42 PRS_PLINK_1.99526231496888e.08 TRUE 578 Gastrointestinal hemorrhage Both 241 824 10 digestive chartreuse4 824, 241 118, 35 263, 83 149, 39 202, 59 -0.00421 0.0788 0.957 0.019 0.996 0.847 1.15 -0.000693 0.238 0.998 0.001 0.999 0.632 1.6 -0.194 0.268 0.47 0.328 0.824 0.488 1.39 -0.107 0.246 0.663 0.179 0.898 0.557 1.46 PRS_PLINK_1.99526231496888e.08 FALSE 578.1 Hematemesis Both 21 104 10 digestive chartreuse4 104, 21 12, 1 35, 8 17, 7 26, 5 0.216 0.316 0.494 0.306 1.24 0.681 2.34 0.777 1.27 0.542 0.266 2.17 0.196 36.4 0.294 1.08 0.785 0.105 1.34 0.163 14.9 0.69 1.03 0.501 0.3 1.99 0.318 20.5 PRS_PLINK_1.99526231496888e.08 TRUE 578.2 Blood in stool Both 146 552 10 digestive chartreuse4 552, 146 80, 24 138, 33 139, 35 136, 37 -0.00609 0.105 0.954 0.021 0.994 0.798 1.21 -0.424 0.322 0.188 0.726 0.654 0.348 1.23 -0.241 0.305 0.431 0.366 0.786 0.435 1.43 -0.149 0.304 0.625 0.204 0.862 0.478 1.57 PRS_PLINK_1.99526231496888e.08 FALSE 578.8 Hemorrhage of rectum and anus Both 125 523 10 digestive chartreuse4 523, 125 76, 19 185, 47 78, 16 129, 31 -0.0685 0.122 0.574 0.241 0.934 0.727 1.18 -0.142 0.319 0.656 0.183 0.867 0.47 1.64 -0.177 0.379 0.641 0.193 0.838 0.397 1.75 -0.236 0.335 0.481 0.318 0.79 0.412 1.53 PRS_PLINK_1.99526231496888e.08 FALSE 578.9 Hemorrhage of gastrointestinal tract Both 54 272 10 digestive chartreuse4 272, 54 38, 7 76, 14 60, 12 68, 18 0.191 0.144 0.186 0.731 1.21 0.927 1.62 0.0133 0.537 0.98 0.009 1.01 0.359 3.06 -0.0808 0.546 0.882 0.054 0.922 0.316 2.8 0.451 0.503 0.37 0.432 1.57 0.609 4.47 PRS_PLINK_1.99526231496888e.08 FALSE 579 Other symptoms involving abdomen and pelvis Both 218 781 10 digestive chartreuse4 781, 218 110, 37 253, 73 140, 36 192, 52 0.0566 0.0708 0.424 0.373 1.06 0.915 1.21 -0.212 0.24 0.377 0.424 0.809 0.509 1.3 -0.354 0.276 0.199 0.701 0.702 0.409 1.2 -0.323 0.254 0.204 0.691 0.724 0.441 1.19 PRS_PLINK_1.99526231496888e.08 FALSE 579.2 Splenomegaly Both 26 160 10 digestive chartreuse4 160, 26 18, 1 47, 8 33, 6 40, 9 0.122 0.162 0.449 0.348 1.13 0.779 1.49 0.855 0.93 0.358 0.446 2.35 0.453 28 1.37 1 0.173 0.761 3.92 0.638 60.2 0.534 0.905 0.555 0.256 1.71 0.305 17.3 PRS_PLINK_1.99526231496888e.08 TRUE 579.8 Nonspecific abnormal findings in stool contents Both 65 296 10 digestive chartreuse4 296, 65 40, 12 94, 25 53, 6 73, 17 -0.124 0.155 0.425 0.372 0.884 0.628 1.17 -0.192 0.4 0.631 0.2 0.825 0.386 1.82 -1.07 0.561 0.0555 1.256 0.341 0.107 1 -0.275 0.448 0.539 0.268 0.759 0.319 1.84 PRS_PLINK_1.99526231496888e.08 FALSE 580 Nephritis; nephrosis; renal sclerosis Both 73 323 11 genitourinary black 323, 73 49, 11 103, 31 59, 8 80, 16 -0.052 0.12 0.666 0.177 0.949 0.718 1.17 0.213 0.403 0.598 0.224 1.24 0.577 2.78 -0.477 0.495 0.335 0.475 0.62 0.227 1.63 -0.16 0.438 0.715 0.146 0.852 0.363 2.04 PRS_PLINK_1.99526231496888e.08 FALSE 580.1 Glomerulonephritis Both 14 85 11 genitourinary black 85, 14 11, 2 22, 8 21, 2 20, 1 -0.222 0.334 0.506 0.296 0.801 0.401 1.51 0.404 0.82 0.622 0.206 1.5 0.36 8.26 -1.75 1.29 0.173 0.761 0.173 0.00315 2.12 -1.66 1.18 0.159 0.798 0.19 0.00515 1.79 PRS_PLINK_1.99526231496888e.08 TRUE 580.11 Proliferative glomerulonephritis Both 8 24 11 genitourinary black 24, 8 4, 1 8, 4 5, 2 5, 0 -0.252 0.68 0.711 0.148 0.778 0.209 2.55 0.961 2.68 0.72 0.143 2.61 0.0361 92100 3.22 4.43 0.467 0.331 25.1 0.0978 31.4 0.103 3.17 0.974 0.011 1.11 0.000963 308 PRS_PLINK_1.99526231496888e.08 TRUE 580.12 Non-proliferative glomerulonephritis Both 4 29 11 genitourinary black 29, 4 6, 0 7, 3 7, 1 7, 0 0.0232 0.761 0.976 0.011 1.02 0.22 5.5 -0.136 1.62 0.933 0.03 0.873 0.805 17.9 1.33 1.89 0.48 0.318 3.79 0.109 539 PRS_PLINK_1.99526231496888e.08 TRUE 580.13 Acute glomerulonephritis, NOS Both 4 10 11 genitourinary black 10, 4 3, 1 1, 1 3, 1 2, 1 -1 2.16 0.643 0.192 0.367 0.357 0.376 0.212 3690 1 0 1.24 0.0988 12.8 -1.17 6940 1 0 0.31 0.0705 0.739 0.796 91.6 0.993 0.003 2.22 0.0959 0.169 PRS_PLINK_1.99526231496888e.08 TRUE 580.14 Chronic glomerulonephritis, NOS Both 8 55 11 genitourinary black 55, 8 8, 1 13, 4 13, 2 14, 0 -0.227 0.469 0.628 0.202 0.797 0.299 2.01 0.648 1.39 0.64 0.194 1.91 0.173 1730 0.571 1.93 0.767 0.115 1.77 0.00902 285 -0.929 1.48 0.529 0.277 0.395 0.00279 15.1 PRS_PLINK_1.99526231496888e.08 TRUE 580.2 Nephrotic syndrome without mention of glomerulonephritis Both 10 46 11 genitourinary black 46, 10 6, 0 13, 7 9, 1 12, 2 -0.081 0.48 0.866 0.062 0.922 0.36 2.34 1.67 1.45 0.252 0.599 5.29 0.538 602 0.583 1.84 0.751 0.124 1.79 0.0934 3760 0.225 1.44 0.875 0.058 1.25 0.104 204 PRS_PLINK_1.99526231496888e.08 TRUE 580.3 Nephritis and nephropathy without mention of glomerulonephritis Both 67 255 11 genitourinary black 255, 67 44, 11 82, 25 45, 8 63, 16 -0.0414 0.123 0.736 0.133 0.959 0.721 1.18 -0.0491 0.429 0.909 0.041 0.952 0.419 2.23 -0.313 0.527 0.553 0.258 0.731 0.255 2.03 -0.0675 0.458 0.883 0.054 0.935 0.385 2.31 PRS_PLINK_1.99526231496888e.08 FALSE 580.31 Nephritis and nephropathy in diseases classified elsewhere Both 48 153 11 genitourinary black 153, 48 26, 8 50, 19 26, 4 38, 13 0.0451 0.139 0.745 0.128 1.05 0.785 1.34 -0.035 0.518 0.946 0.024 0.966 0.363 2.67 -0.734 0.67 0.274 0.563 0.48 0.118 1.68 -0.00878 0.546 0.987 0.006 0.991 0.353 2.85 PRS_PLINK_1.99526231496888e.08 TRUE 580.32 Nephritis and nephropathy with pathological lesion Both 32 155 11 genitourinary black 155, 32 24, 5 46, 10 31, 4 39, 9 -0.131 0.183 0.475 0.323 0.877 0.53 1.17 0.0464 0.624 0.941 0.027 1.05 0.32 3.7 0.228 0.754 0.762 0.118 1.26 0.288 6.03 0.156 0.68 0.818 0.087 1.17 0.321 4.4 PRS_PLINK_1.99526231496888e.08 TRUE 580.4 Renal sclerosis, NOS Both 9 68 11 genitourinary black 68, 9 13, 0 16, 6 17, 1 17, 1 -0.854 0.537 0.112 0.951 0.426 0.126 1.21 3.08 2.06 0.136 0.868 21.7 0.883 3.94e+15 0.702 1.38 0.611 0.214 2.02 0.0512 191 0.407 1.23 0.742 0.13 1.5 0.0879 69 PRS_PLINK_1.99526231496888e.08 TRUE 585 Renal failure Both 178 786 11 genitourinary black 786, 178 119, 25 256, 65 135, 28 197, 43 -0.0651 0.0975 0.504 0.297 0.937 0.763 1.12 0.148 0.27 0.582 0.235 1.16 0.691 1.99 0.0591 0.31 0.849 0.071 1.06 0.579 1.96 0.0217 0.284 0.939 0.027 1.02 0.59 1.8 PRS_PLINK_1.99526231496888e.08 FALSE 585.1 Acute renal failure Both 105 558 11 genitourinary black 558, 105 90, 20 178, 39 98, 16 140, 20 -0.183 0.136 0.178 0.751 0.832 0.631 1.08 -0.0104 0.309 0.973 0.012 0.99 0.546 1.84 -0.321 0.366 0.38 0.42 0.725 0.35 1.48 -0.479 0.344 0.164 0.786 0.619 0.313 1.22 PRS_PLINK_1.99526231496888e.08 FALSE 585.2 Renal failure NOS Both 23 151 11 genitourinary black 151, 23 18, 1 54, 11 21, 3 38, 5 -0.105 0.287 0.713 0.147 0.9 0.512 1.59 0.961 0.899 0.285 0.545 2.61 0.533 25.9 -0.183 1.25 0.884 0.054 0.833 0.00298 39.3 0.983 1.04 0.346 0.46 2.67 0.383 44.1 PRS_PLINK_1.99526231496888e.08 TRUE 585.3 Chronic renal failure [CKD] Both 125 632 11 genitourinary black 632, 125 95, 12 208, 46 108, 19 158, 35 0.00496 0.11 0.964 0.016 1 0.798 1.23 0.468 0.345 0.175 0.758 1.6 0.831 3.27 0.421 0.391 0.282 0.549 1.52 0.71 3.39 0.514 0.354 0.146 0.836 1.67 0.854 3.47 PRS_PLINK_1.99526231496888e.08 FALSE 585.31 Renal dialysis Both 12 138 11 genitourinary black 138, 12 18, 0 45, 5 22, 1 35, 3 -0.192 0.349 0.582 0.235 0.825 0.397 1.73 1.06 1.21 0.383 0.417 2.88 0.263 410 0.212 1.17 0.856 0.068 1.24 0.0805 88 1.38 1.26 0.275 0.561 3.97 0.341 543 PRS_PLINK_1.99526231496888e.08 TRUE 585.32 End stage renal disease Both 25 184 11 genitourinary black 184, 25 29, 1 45, 6 46, 7 46, 8 0.113 0.187 0.547 0.262 1.12 0.692 1.52 0.936 0.845 0.268 0.572 2.55 0.519 24.3 1.21 0.846 0.153 0.815 3.35 0.683 33.8 1.63 1.01 0.105 0.979 5.11 0.777 74.9 PRS_PLINK_1.99526231496888e.08 TRUE 585.33 Chronic Kidney Disease, Stage III Both 65 364 11 genitourinary black 364, 65 59, 4 124, 23 58, 7 91, 22 0.0651 0.145 0.653 0.185 1.07 0.777 1.38 1.01 0.54 0.062 1.208 2.74 1.01 9.19 0.579 0.593 0.329 0.483 1.78 0.544 6.63 1.23 0.547 0.0252 1.598 3.41 1.23 11.7 PRS_PLINK_1.99526231496888e.08 FALSE 585.34 Chronic Kidney Disease, Stage IV Both 24 143 11 genitourinary black 143, 24 24, 2 45, 7 26, 4 36, 8 0.0186 0.299 0.95 0.022 1.02 0.569 1.86 0.505 0.772 0.514 0.289 1.66 0.374 9.96 0.5 0.789 0.526 0.279 1.65 0.356 9.14 0.689 0.801 0.39 0.409 1.99 0.432 12.1 PRS_PLINK_1.99526231496888e.08 TRUE 585.4 Chronic kidney disease, Stage I or II Both 35 192 11 genitourinary black 192, 35 29, 3 59, 16 37, 7 48, 8 0.0834 0.17 0.623 0.206 1.09 0.725 1.44 0.931 0.653 0.154 0.813 2.54 0.771 10.6 0.808 0.716 0.259 0.586 2.24 0.596 10.5 0.534 0.727 0.462 0.335 1.71 0.433 8.26 PRS_PLINK_1.99526231496888e.08 TRUE 586 Other disorders of the kidney and ureters Both 246 884 11 genitourinary black 884, 246 129, 35 289, 78 153, 39 221, 72 0.0577 0.0743 0.438 0.359 1.06 0.911 1.22 -0.0861 0.241 0.721 0.142 0.918 0.576 1.48 -0.0285 0.274 0.917 0.037 0.972 0.57 1.66 0.144 0.245 0.555 0.256 1.16 0.721 1.87 PRS_PLINK_1.99526231496888e.08 FALSE 586.1 Anatomical abnormatilies of kidney and ureters Both 14 86 11 genitourinary black 86, 14 10, 1 27, 6 15, 2 22, 2 -0.349 0.371 0.346 0.461 0.705 0.336 1.44 2.28 1.97 0.246 0.609 9.82 0.406 98800 -0.0256 1.16 0.982 0.008 0.975 0.0614 12.5 0.217 1.58 0.89 0.05 1.24 0.0133 153000 PRS_PLINK_1.99526231496888e.08 TRUE 586.11 Small kidney Both 5 37 11 genitourinary black 37, 5 5, 0 9, 4 9, 1 9, 0 -1.13 0.792 0.154 0.812 0.323 0.0391 1.57 1.76 2.27 0.438 0.358 5.8 0.0579 3670 -0.137 2.23 0.951 0.022 0.872 0.00643 147 PRS_PLINK_1.99526231496888e.08 TRUE 586.12 Vesicoureteral reflux Both 10 42 11 genitourinary black 42, 10 7, 1 13, 2 7, 2 11, 2 -0.33 0.483 0.494 0.306 0.719 0.277 1.73 0.239 1.52 0.875 0.058 1.27 0.053 126 -0.537 2.09 0.798 0.098 0.584 0.00286 4080000 -0.204 1.83 0.911 0.04 0.816 5.96e-08 178 PRS_PLINK_1.99526231496888e.08 TRUE 586.2 Cyst of kidney, acquired Both 42 191 11 genitourinary black 191, 42 34, 7 57, 14 36, 7 47, 11 0.0941 0.247 0.703 0.153 1.1 0.68 1.8 0.242 0.51 0.634 0.198 1.27 0.488 3.58 0.434 0.651 0.505 0.296 1.54 0.431 5.79 0.461 0.574 0.422 0.375 1.59 0.541 5.11 PRS_PLINK_1.99526231496888e.08 TRUE 586.3 Vascular disorders of kidney/hypertrophy Both 4 29 11 genitourinary black 29, 4 4, 0 7, 1 7, 1 7, 0 -0.252 0.776 0.746 0.128 0.777 0.13 4.54 0.0708 2.02 0.972 0.012 1.07 0.0552 781 2.5 6.35 0.694 0.159 12.1 0.00116 4.83e+08 PRS_PLINK_1.99526231496888e.08 TRUE 586.4 Stricture/obstruction of ureter Both 55 327 11 genitourinary black 327, 55 47, 7 102, 15 60, 6 82, 20 0.205 0.133 0.124 0.907 1.23 0.951 1.59 -0.231 0.489 0.636 0.196 0.793 0.312 2.15 -0.204 0.595 0.732 0.136 0.816 0.247 2.67 0.617 0.494 0.212 0.675 1.85 0.736 5.19 PRS_PLINK_1.99526231496888e.08 FALSE 587 Kidney replaced by transpant Both 20 166 11 genitourinary black 166, 20 28, 0 44, 6 39, 8 41, 4 0.145 0.214 0.498 0.303 1.16 0.695 1.66 2.33 1.27 0.0677 1.17 10.2 1.03 1390 2.18 1.17 0.063 1.2 8.84 1.18 1070 2.16 1.43 0.131 0.881 8.64 0.529 275000 PRS_PLINK_1.99526231496888e.08 TRUE 588 Disorders resulting from impaired renal function Both 34 171 11 genitourinary black 171, 34 28, 3 50, 11 33, 10 43, 8 0.0718 0.174 0.679 0.168 1.07 0.71 1.43 0.922 0.699 0.187 0.728 2.52 0.708 12.2 0.877 0.647 0.175 0.756 2.4 0.718 9.9 0.367 0.672 0.586 0.232 1.44 0.406 6.11 PRS_PLINK_1.99526231496888e.08 TRUE 588.1 Renal osteodystrophy Both 9 53 11 genitourinary black 53, 9 9, 0 15, 4 11, 3 13, 2 -0.0107 0.578 0.985 0.006 0.989 0.31 3.17 1.59 1.73 0.356 0.449 4.92 0.358 365000 0.318 1.49 0.831 0.08 1.37 0.0766 149 -0.0371 1.53 0.981 0.008 0.964 0.00785 32.8 PRS_PLINK_1.99526231496888e.08 TRUE 588.2 Secondary hyperparathyroidism (of renal origin) Both 30 122 11 genitourinary black 122, 30 21, 4 34, 8 25, 10 31, 6 0.0488 0.183 0.789 0.103 1.05 0.666 1.41 0.556 0.727 0.444 0.352 1.74 0.458 7.75 0.587 0.659 0.373 0.428 1.8 0.53 6.84 -0.228 0.707 0.747 0.127 0.796 0.193 3.25 PRS_PLINK_1.99526231496888e.08 TRUE 589 Abnormal results of function study of kidney Both 37 200 11 genitourinary black 200, 37 30, 4 64, 12 34, 6 50, 10 0.0781 0.199 0.694 0.158 1.08 0.653 1.51 0.155 0.586 0.792 0.101 1.17 0.386 4.1 0.321 0.721 0.657 0.183 1.38 0.302 6.61 0.277 0.651 0.67 0.174 1.32 0.369 5.36 PRS_PLINK_1.99526231496888e.08 TRUE 590 Pyelonephritis Both 91 385 11 genitourinary black 385, 91 53, 10 126, 39 64, 9 96, 22 -0.0425 0.112 0.704 0.152 0.958 0.746 1.17 0.594 0.4 0.137 0.862 1.81 0.858 4.12 -0.258 0.511 0.613 0.212 0.773 0.277 2.14 0.153 0.427 0.719 0.143 1.17 0.514 2.77 PRS_PLINK_1.99526231496888e.08 FALSE 591 Urinary tract infection Both 494 665 11 genitourinary black 665, 494 94, 48 219, 191 112, 71 166, 137 0.0432 0.0606 0.476 0.323 1.04 0.928 1.17 0.46 0.22 0.0362 1.441 1.58 1.04 2.44 0.194 0.246 0.429 0.367 1.21 0.756 1.96 0.465 0.221 0.0355 1.45 1.59 1.04 2.46 PRS_PLINK_1.99526231496888e.08 FALSE 592 Cystitis and urethritis Both 159 580 11 genitourinary black 580, 159 78, 15 195, 57 98, 18 142, 51 0.0797 0.0783 0.309 0.51 1.08 0.924 1.25 0.515 0.346 0.137 0.864 1.67 0.869 3.39 0.0357 0.387 0.926 0.033 1.04 0.486 2.25 0.399 0.345 0.248 0.605 1.49 0.772 2.99 PRS_PLINK_1.99526231496888e.08 FALSE 592.1 Cystitis Both 149 567 11 genitourinary black 567, 149 75, 14 190, 52 96, 17 139, 48 0.0354 0.0858 0.68 0.168 1.04 0.866 1.21 0.417 0.352 0.237 0.626 1.52 0.779 3.12 0.021 0.398 0.958 0.019 1.02 0.467 2.27 0.355 0.352 0.313 0.504 1.43 0.73 2.9 PRS_PLINK_1.99526231496888e.08 FALSE 592.11 Acute cystitis Both 101 387 11 genitourinary black 387, 101 50, 12 124, 34 70, 12 96, 29 -0.145 0.138 0.293 0.533 0.865 0.655 1.13 0.277 0.427 0.517 0.287 1.32 0.591 3.13 -0.231 0.472 0.624 0.205 0.794 0.311 2.03 0.136 0.423 0.749 0.126 1.15 0.512 2.66 PRS_PLINK_1.99526231496888e.08 FALSE 592.12 Chronic cystitis Both 14 65 11 genitourinary black 65, 14 11, 3 19, 2 12, 4 16, 3 0.252 0.308 0.412 0.385 1.29 0.511 2.29 -0.118 1.09 0.914 0.039 0.889 0.0775 9.05 -0.0818 1.04 0.937 0.028 0.921 0.113 7.73 -0.298 1.34 0.823 0.084 0.742 0.0248 22.1 PRS_PLINK_1.99526231496888e.08 TRUE 592.13 Chronic interstitial cystitis Both 34 138 11 genitourinary black 138, 34 15, 3 53, 11 16, 6 34, 12 0.452 0.261 0.0834 1.079 1.57 1.04 3.06 -0.0259 0.792 0.974 0.011 0.974 0.223 5.37 0.572 0.927 0.537 0.27 1.77 0.329 11.9 0.486 0.765 0.526 0.279 1.63 0.412 7.72 PRS_PLINK_1.99526231496888e.08 TRUE 592.2 Urethritis and urethral syndrome Both 16 60 11 genitourinary black 60, 16 11, 5 19, 4 10, 1 15, 5 0.196 0.22 0.372 0.429 1.22 0.842 1.94 -1.14 0.964 0.237 0.625 0.32 0.0386 1.94 -0.849 1.17 0.467 0.331 0.428 0.019 3.09 -0.398 0.811 0.623 0.205 0.672 0.139 2.98 PRS_PLINK_1.99526231496888e.08 TRUE 593 Hematuria Both 227 648 11 genitourinary black 648, 227 88, 22 217, 84 109, 31 160, 70 0.119 0.0743 0.109 0.963 1.13 0.973 1.3 0.41 0.292 0.16 0.797 1.51 0.866 2.7 0.0939 0.323 0.771 0.113 1.1 0.587 2.08 0.513 0.286 0.0733 1.135 1.67 0.969 2.96 PRS_PLINK_1.99526231496888e.08 FALSE 593.1 Gross hematuria Both 58 210 11 genitourinary black 210, 58 32, 7 51, 16 51, 10 53, 19 0.00424 0.138 0.975 0.011 1 0.719 1.26 0.106 0.532 0.842 0.075 1.11 0.407 3.2 -0.0801 0.528 0.879 0.056 0.923 0.332 2.66 0.401 0.514 0.435 0.361 1.49 0.572 4.22 PRS_PLINK_1.99526231496888e.08 FALSE 593.2 Microscopic hematuria Both 58 198 11 genitourinary black 198, 58 28, 6 65, 13 32, 9 49, 23 0.25 0.165 0.13 0.886 1.28 0.948 1.8 0.345 0.607 0.571 0.244 1.41 0.453 5.26 0.485 0.663 0.464 0.333 1.62 0.472 6.24 0.951 0.582 0.102 0.99 2.59 0.89 8.74 PRS_PLINK_1.99526231496888e.08 FALSE 594 Urinary calculus Both 205 1030 11 genitourinary black 1030, 205 144, 31 354, 64 167, 32 251, 61 0.0217 0.0758 0.775 0.111 1.02 0.871 1.17 -0.222 0.243 0.362 0.441 0.801 0.5 1.3 -0.157 0.276 0.569 0.245 0.855 0.496 1.47 0.0591 0.247 0.811 0.091 1.06 0.658 1.73 PRS_PLINK_1.99526231496888e.08 FALSE 594.1 Calculus of kidney Both 190 1028 11 genitourinary black 1028, 190 144, 29 354, 58 166, 28 250, 59 0.0261 0.0778 0.737 0.133 1.03 0.871 1.18 -0.281 0.25 0.261 0.583 0.755 0.464 1.25 -0.234 0.288 0.416 0.381 0.791 0.447 1.39 0.0953 0.252 0.705 0.152 1.1 0.677 1.82 PRS_PLINK_1.99526231496888e.08 FALSE 594.2 Calculus of lower urinary tract Both 11 55 11 genitourinary black 55, 11 8, 0 16, 2 11, 2 14, 5 0.011 0.518 0.983 0.007 1.01 0.366 2.92 0.752 1.55 0.628 0.202 2.12 0.0647 310 0.879 1.37 0.522 0.283 2.41 0.236 5160 0.962 1.43 0.501 0.301 2.62 0.149 2500 PRS_PLINK_1.99526231496888e.08 TRUE 594.3 Calculus of ureter Both 59 324 11 genitourinary black 324, 59 39, 11 81, 9 81, 12 81, 20 0.0622 0.127 0.624 0.205 1.06 0.792 1.32 -0.848 0.491 0.0843 1.074 0.428 0.159 1.12 -0.856 0.486 0.0782 1.107 0.425 0.162 1.09 -0.0874 0.474 0.854 0.069 0.916 0.37 2.36 PRS_PLINK_1.99526231496888e.08 FALSE 594.8 Renal colic Both 21 114 11 genitourinary black 114, 21 10, 2 28, 7 28, 4 29, 6 0.0872 0.204 0.668 0.175 1.09 0.692 1.55 -1.22 1.13 0.283 0.549 0.296 0.0169 2.7 -0.59 1.05 0.575 0.24 0.554 0.0411 5.1 0.0119 0.917 0.99 0.005 1.01 0.193 6.74 PRS_PLINK_1.99526231496888e.08 TRUE 595 Hydronephrosis Both 50 435 11 genitourinary black 435, 50 59, 6 152, 18 67, 4 107, 16 -0.038 0.169 0.822 0.085 0.963 0.65 1.29 0.183 0.485 0.706 0.151 1.2 0.475 3.4 -0.445 0.612 0.468 0.33 0.641 0.168 2.25 0.299 0.523 0.568 0.246 1.35 0.493 4.12 PRS_PLINK_1.99526231496888e.08 TRUE 596 Other disorders of bladder Both 98 648 11 genitourinary black 648, 98 100, 12 194, 39 128, 15 159, 21 -0.111 0.132 0.403 0.395 0.895 0.679 1.15 0.467 0.356 0.19 0.722 1.6 0.81 3.33 0.13 0.413 0.752 0.124 1.14 0.502 2.65 0.0392 0.398 0.921 0.036 1.04 0.477 2.35 PRS_PLINK_1.99526231496888e.08 FALSE 596.1 Bladder neck obstruction Both 5 37 11 genitourinary black 37, 5 4, 0 9, 1 9, 1 9, 3 0.884 0.779 0.256 0.591 2.42 0.542 22.8 -0.256 1.96 0.896 0.048 0.774 0.00384 97.2 2.36 3.13 0.451 0.346 10.6 0.111 27500 -0.0285 2.33 0.99 0.004 0.972 0.00213 608 PRS_PLINK_1.99526231496888e.08 TRUE 596.5 Functional disorders of bladder Both 70 414 11 genitourinary black 414, 70 62, 6 123, 26 81, 12 104, 16 -0.12 0.161 0.456 0.342 0.887 0.639 1.21 1.02 0.504 0.0422 1.375 2.78 1.09 8.2 0.627 0.533 0.239 0.621 1.87 0.662 5.81 0.601 0.529 0.255 0.593 1.82 0.659 5.75 PRS_PLINK_1.99526231496888e.08 FALSE 597 Other disorders of urethra and urinary tract Both 34 210 11 genitourinary black 210, 34 33, 4 68, 13 36, 6 53, 11 0.344 0.194 0.0757 1.121 1.41 1.01 2.21 0.29 0.603 0.631 0.2 1.34 0.424 4.8 0.218 0.707 0.758 0.12 1.24 0.306 5.59 0.663 0.667 0.32 0.495 1.94 0.55 8.38 PRS_PLINK_1.99526231496888e.08 TRUE 597.1 Urethral stricture (not specified as infectious) Both 13 77 11 genitourinary black 77, 13 12, 1 22, 6 16, 2 19, 4 0.264 0.258 0.306 0.514 1.3 0.872 2.93 0.593 1.09 0.588 0.231 1.81 0.243 25.7 -0.588 1.42 0.68 0.167 0.556 0.00379 19100 -0.107 1.26 0.933 0.03 0.899 0.000805 33.7 PRS_PLINK_1.99526231496888e.08 TRUE 597.2 Urinary complications NEC Both 23 194 11 genitourinary black 194, 23 31, 3 54, 8 42, 6 49, 4 -0.32 0.289 0.267 0.573 0.726 0.403 1.29 0.481 0.693 0.488 0.311 1.62 0.427 7.75 0.269 0.71 0.705 0.152 1.31 0.334 5.89 -0.34 0.77 0.659 0.181 0.712 0.136 3.84 PRS_PLINK_1.99526231496888e.08 TRUE 597.8 Urethral hypermobility/ISD Both 5 49 11 genitourinary black 49, 5 11, 2 14, 0 10, 2 11, 1 -0.555 0.78 0.477 0.322 0.574 0.0296 2.76 -3.27 2.55 0.2 0.698 0.0381 3.61e-07 2.98 -3.22 3.72 0.387 0.412 0.0401 9.68e-10 72.2 -0.288 1.36 0.832 0.08 0.75 0.0196 11.1 PRS_PLINK_1.99526231496888e.08 TRUE 598 Abnormal findings on examination of urine Both 10 20 11 genitourinary black 20, 10 3, 1 6, 2 3, 3 5, 0 -0.15 0.319 0.639 0.195 0.861 0.299 1.36 -0.312 2.92 0.915 0.039 0.732 0.00904 771 5.13 56.8 0.928 0.032 170 131 221 -0.0936 3.19 0.977 0.01 0.911 0.00306 171 PRS_PLINK_1.99526231496888e.08 TRUE 598.4 Other cells and casts in urine Both 9 20 11 genitourinary black 20, 9 2, 1 7, 2 3, 1 5, 1 -0.0764 0.323 0.813 0.09 0.926 0.31 1.51 -1.34 2.6 0.607 0.217 0.263 0.23 8.8 0.762 2400 1 0 2.14 0.00541 2810 7.44 28.3 0.792 0.101 1700 0.0032 3040 PRS_PLINK_1.99526231496888e.08 TRUE 599 Other symptoms/disorders or the urinary system Both 618 622 11 genitourinary black 622, 618 87, 80 216, 212 96, 104 154, 161 0.0252 0.0583 0.666 0.177 1.03 0.915 1.15 -0.0955 0.194 0.623 0.206 0.909 0.623 1.32 0.162 0.221 0.463 0.334 1.18 0.767 1.81 0.0219 0.2 0.913 0.04 1.02 0.693 1.51 PRS_PLINK_1.99526231496888e.08 FALSE 599.1 Urinary obstruction Both 18 54 11 genitourinary black 54, 18 11, 5 13, 1 13, 3 14, 6 -0.389 0.391 0.319 0.496 0.678 0.321 1.41 -0.532 1.23 0.665 0.177 0.587 0.0341 15.6 -1.22 1.22 0.317 0.498 0.296 0.0037 2.52 1.12 1.12 0.316 0.5 3.08 0.382 35.7 PRS_PLINK_1.99526231496888e.08 TRUE 599.2 Retention of urine Both 129 542 11 genitourinary black 542, 129 81, 14 141, 32 127, 37 136, 34 0.103 0.0909 0.258 0.589 1.11 0.919 1.31 0.0435 0.36 0.904 0.044 1.04 0.522 2.15 0.398 0.345 0.248 0.606 1.49 0.771 3 0.102 0.372 0.785 0.105 1.11 0.538 2.34 PRS_PLINK_1.99526231496888e.08 FALSE 599.3 Dysuria Both 281 594 11 genitourinary black 594, 281 84, 32 207, 98 87, 46 149, 81 0.0757 0.0732 0.301 0.522 1.08 0.934 1.24 0.123 0.254 0.627 0.203 1.13 0.695 1.87 0.376 0.289 0.193 0.715 1.46 0.837 2.56 0.268 0.261 0.304 0.518 1.31 0.792 2.18 PRS_PLINK_1.99526231496888e.08 FALSE 599.4 Urinary incontinence Both 215 565 11 genitourinary black 565, 215 80, 33 142, 45 142, 62 138, 53 -0.0668 0.1 0.506 0.296 0.935 0.759 1.13 -0.501 0.303 0.0978 1.01 0.606 0.336 1.09 0.0106 0.287 0.971 0.013 1.01 0.581 1.77 -0.258 0.291 0.376 0.425 0.773 0.439 1.36 PRS_PLINK_1.99526231496888e.08 FALSE 599.5 Frequency of urination and polyuria Both 278 598 11 genitourinary black 598, 278 83, 37 149, 53 148, 69 150, 90 0.109 0.067 0.104 0.982 1.12 0.979 1.27 -0.502 0.276 0.0693 1.159 0.605 0.353 1.03 -0.0603 0.254 0.813 0.09 0.942 0.577 1.54 0.194 0.247 0.433 0.364 1.21 0.755 1.97 PRS_PLINK_1.99526231496888e.08 FALSE 599.6 Oliguria and anuria Both 8 67 11 genitourinary black 67, 8 7, 0 17, 2 16, 1 17, 3 0.331 0.462 0.474 0.325 1.39 0.555 3.87 1.56 1.75 0.373 0.429 4.77 0.213 634 0.234 1.46 0.872 0.059 1.26 0.0349 345 0.815 1.46 0.577 0.239 2.26 0.174 1820 PRS_PLINK_1.99526231496888e.08 TRUE 599.7 Urethral discharge Both 7 10 11 genitourinary black 10, 7 3, 0 2, 1 2, 2 3, 3 0.624 2 0.755 0.122 1.87 0.0284 424 0.0426 307 1 0 1.04 0.573 1.73 1.19 3300 1 0 3.28 0.14 9590 3.06 72.9 0.967 0.015 21.3 181 290 PRS_PLINK_1.99526231496888e.08 TRUE 599.8 Other symptoms involving urinary system Both 225 584 11 genitourinary black 584, 225 80, 35 146, 57 149, 52 143, 58 -0.0128 0.0847 0.879 0.056 0.987 0.828 1.15 -0.324 0.274 0.236 0.627 0.723 0.425 1.23 -0.365 0.277 0.188 0.725 0.694 0.405 1.19 -0.238 0.272 0.38 0.42 0.788 0.465 1.34 PRS_PLINK_1.99526231496888e.08 FALSE 599.9 Other abnormality of urination Both 147 502 11 genitourinary black 502, 147 70, 18 174, 42 76, 27 125, 49 0.176 0.08 0.0283 1.548 1.19 1.03 1.4 -0.245 0.326 0.453 0.344 0.783 0.419 1.49 0.362 0.361 0.315 0.501 1.44 0.718 2.93 0.304 0.319 0.34 0.468 1.36 0.738 2.56 PRS_PLINK_1.99526231496888e.08 FALSE 600 Hyperplasia of prostate Male 70 78 11 genitourinary black 78, 70 16, 12 25, 21 13, 12 20, 17 0.0279 0.279 0.92 0.036 1.03 0.599 1.77 0.0627 0.611 0.918 0.037 1.06 0.324 3.48 0.609 0.775 0.432 0.364 1.84 0.439 8.7 -0.136 0.661 0.837 0.077 0.873 0.246 3.02 PRS_PLINK_1.99526231496888e.08 FALSE 601 Inflammatory diseases of prostate Male 41 83 11 genitourinary black 83, 41 16, 9 25, 9 16, 10 21, 7 0.0017 0.212 0.994 0.003 1 0.599 1.41 -0.574 0.648 0.376 0.425 0.563 0.16 1.87 -0.135 0.662 0.838 0.077 0.874 0.251 2.91 -0.17 0.656 0.796 0.099 0.844 0.246 2.83 PRS_PLINK_1.99526231496888e.08 TRUE 601.1 Prostatitis Male 18 35 11 genitourinary black 35, 18 8, 5 10, 3 6, 2 9, 3 -0.4 0.434 0.357 0.448 0.67 0.285 1.47 -1.22 1.15 0.287 0.542 0.294 0.0139 2 0.72 1.5 0.631 0.2 2.06 0.0994 59.8 -1.25 1.33 0.348 0.459 0.288 0.0169 2.83 PRS_PLINK_1.99526231496888e.08 TRUE 601.11 Acute prostatitis Male 5 8 11 genitourinary black 8, 5 2, 1 2, 2 2, 0 2, 0 -1.39 1.48 0.347 0.46 0.248 0.00185 2.04 0.501 2610 1 0 1.65 1.16e-09 2.43e+08 0.144 3320 1 0 1.16 0.0123 41.8 -0.0738 710 1 0 0.929 2.71e-07 6.9e+08 PRS_PLINK_1.99526231496888e.08 TRUE 601.12 Chronic prostatitis Male 1 10 11 genitourinary black 10, 1 2, 0 2, 0 3, 0 2, 1 0.397 2.35 0.866 0.063 1.49 0.00933 346 -0.0522 2510 1 0 0.949 0.53 16.8 PRS_PLINK_1.99526231496888e.08 TRUE 601.3 Orchitis and epididymitis Male 18 33 11 genitourinary black 33, 18 8, 6 7, 2 8, 8 8, 2 0.0373 0.236 0.875 0.058 1.04 0.64 1.53 -0.988 1.13 0.382 0.418 0.372 0.0407 2.36 -0.0354 0.9 0.969 0.014 0.965 0.186 4.69 -0.672 1.25 0.59 0.229 0.511 0.0332 4.27 PRS_PLINK_1.99526231496888e.08 TRUE 601.4 Balanoposthitis Male 7 11 11 genitourinary black 11, 7 3, 3 2, 1 2, 0 3, 2 -0.224 0.949 0.813 0.09 0.799 0.0526 3.84 2.25 213 0.992 0.004 9.45 4.99e-14 9.97e+16 -3.64 144 0.98 0.009 0.0264 1.72e-10 0.0322 1.13 4.89 0.817 0.088 3.1 2.64 3.47 PRS_PLINK_1.99526231496888e.08 TRUE 601.8 Other inflammatory disorders of male genital organs Male 8 6 11 genitourinary black 6, 8 2, 2 1, 1 1, 4 2, 0 -0.258 0.587 0.661 0.18 0.773 0.24 2.11 0.0272 640 1 0 1.03 0.932 1.22 0.304 74.8 0.997 0.001 1.36 1.1 1.73 -0.06 3830 1 0 0.942 0.264 2.95 PRS_PLINK_1.99526231496888e.08 TRUE 602 Other disorders of prostate Male 7 16 11 genitourinary black 16, 7 4, 3 4, 1 4, 2 4, 0 -1.22 0.984 0.216 0.666 0.296 0.00246 1.62 1.91 2.6 0.462 0.336 6.77 0.189 279000 -0.129 1.76 0.942 0.026 0.879 0.00174 119 -1.2 1.88 0.524 0.281 0.302 0.011 7.47 PRS_PLINK_1.99526231496888e.08 TRUE 602.3 Dysplasia of prostate Male 0 3 11 genitourinary black 3, 0 1 1 1 1 PRS_PLINK_1.99526231496888e.08 TRUE 603 Other disorders of testis Male 11 16 11 genitourinary black 16, 11 3, 2 6, 3 2, 0 4, 4 0.654 0.699 0.349 0.457 1.92 0.605 8.85 -0.329 1.56 0.833 0.079 0.72 0.0273 54 -0.238 1350 1 0 0.788 0.0977 2.07 1.1 1.88 0.558 0.253 3 0.165 504 PRS_PLINK_1.99526231496888e.08 TRUE 603.1 Hydrocele Male 8 13 11 genitourinary black 13, 8 4, 4 3, 2 3, 0 3, 1 -0.479 1 0.633 0.199 0.619 0.0448 3.61 0.356 2.43 0.884 0.054 1.43 0.00968 60.6 0.256 5.04 0.96 0.018 1.29 1.07 1.46 1.91 3.39 0.573 0.242 6.76 0.0559 43900 PRS_PLINK_1.99526231496888e.08 TRUE 603.2 Spermatocele Male 3 7 11 genitourinary black 7, 3 2, 1 2, 2 1, 0 2, 0 0.225 254 0.999 0 1.25 1.23 1.27 -0.118 72.8 0.999 0.001 0.888 0.762 1.18 0.0909 9470 1 0 1.1 0.238 1.23 0.21 9730 1 0 1.23 0.299 1.39 PRS_PLINK_1.99526231496888e.08 TRUE 604 Disorders of penis Male 26 24 11 genitourinary black 24, 26 4, 13 6, 3 6, 5 6, 2 -0.427 0.47 0.364 0.439 0.652 0.256 1.52 -1.58 1.07 0.141 0.852 0.207 0.0214 1.19 -0.959 1.02 0.349 0.457 0.383 0.0509 2.36 -2.17 1.22 0.0747 1.127 0.114 0.00754 0.83 PRS_PLINK_1.99526231496888e.08 TRUE 604.1 Redundant prepuce and phimosis/BXO Male 2 6 11 genitourinary black 6, 2 1, 1 2, 0 0, 1 2, 0 -1.21 30.7 0.969 0.014 0.298 0.000233 0.333 0.147 400 1 0 1.16 0.0798 14.5 0.0779 8990 1 0 1.08 0.614 2.86 -0.376 1040 1 0 0.687 0.0726 17 PRS_PLINK_1.99526231496888e.08 TRUE 604.3 Peyronie's disease Male 9 6 11 genitourinary black 6, 9 2, 5 2, 2 2, 1 2, 5 0.391 1.99 0.844 0.074 1.48 0.0715 140 -1.07 1.81 0.555 0.256 0.343 0.000248 4.94 -0.176 4.2 0.967 0.015 0.838 5.86e-05 1530 PRS_PLINK_1.99526231496888e.08 TRUE 605 Erectile dysfunction [ED] Male 132 42 11 genitourinary black 42, 132 8, 37 10, 30 10, 30 11, 19 -0.369 0.261 0.158 0.803 0.691 0.388 1.1 -1.54 0.721 0.0326 1.486 0.214 0.0448 0.812 -0.819 0.665 0.218 0.662 0.441 0.11 1.57 -1.3 0.714 0.0691 1.161 0.273 0.0635 1.02 PRS_PLINK_1.99526231496888e.08 FALSE 608 Other disorders of male genital organs Male 63 47 11 genitourinary black 47, 63 10, 18 11, 11 11, 16 12, 14 -0.0765 0.164 0.641 0.193 0.926 0.668 1.24 -1.24 0.73 0.0883 1.054 0.288 0.0652 1.02 -0.6 0.637 0.346 0.46 0.549 0.149 1.75 -1.28 0.756 0.0897 1.047 0.277 0.0582 1.03 PRS_PLINK_1.99526231496888e.08 FALSE 609 Male infertility and abnormal spermatozoa Male 60 20 11 genitourinary black 20, 60 7, 25 2, 3 5, 14 5, 12 -0.185 0.183 0.313 0.504 0.831 0.589 1.16 -0.203 1.32 0.878 0.057 0.817 0.0834 10.5 0.735 0.845 0.384 0.416 2.09 0.46 13.5 -0.533 0.743 0.473 0.325 0.587 0.144 2.35 PRS_PLINK_1.99526231496888e.08 FALSE 609.1 Infertility, male Male 48 11 11 genitourinary black 11, 48 3, 20 2, 6 2, 6 3, 12 0.0889 0.326 0.785 0.105 1.09 0.632 2.42 -0.543 1.24 0.66 0.18 0.581 0.00458 7.5 0.00528 1.24 0.997 0.001 1.01 0.104 17 0.119 1.04 0.909 0.042 1.13 0.147 9.79 PRS_PLINK_1.99526231496888e.08 TRUE 609.11 Azoospermia and oligospermia Male 23 4 11 genitourinary black 4, 23 0, 1 1, 1 1, 5 1, 13 0.401 0.496 0.418 0.378 1.49 0.7 9.29 0.0252 830 1 0 1.03 0.844 1.29 1.01 102 0.992 0.003 2.74 3.62 118 3.56 4.72 0.45 0.347 35.3 0.016 1.58e+10 PRS_PLINK_1.99526231496888e.08 TRUE 609.2 Abnormal spermatozoa Male 17 7 11 genitourinary black 7, 17 2, 7 2, 2 1, 4 2, 2 0.527 1.12 0.638 0.195 1.69 0.000278 20.6 -0.299 1.78 0.867 0.062 0.742 0.00149 22.1 1.21 1.78 0.495 0.306 3.37 0.137 1920 -0.254 1.54 0.869 0.061 0.775 0.0117 13.6 PRS_PLINK_1.99526231496888e.08 TRUE 610 Benign mammary dysplasias Female 258 445 11 genitourinary black 445, 258 56, 33 150, 86 71, 52 111, 62 0.113 0.0784 0.151 0.822 1.12 0.964 1.31 -0.00707 0.292 0.981 0.008 0.993 0.566 1.76 0.229 0.323 0.48 0.319 1.26 0.673 2.37 -0.0436 0.291 0.881 0.055 0.957 0.546 1.69 PRS_PLINK_1.99526231496888e.08 FALSE 610.1 Cystic mastopathy Female 110 315 11 genitourinary black 315, 110 38, 13 104, 37 54, 23 78, 25 0.0331 0.115 0.773 0.112 1.03 0.821 1.28 0.152 0.416 0.716 0.145 1.16 0.53 2.66 0.369 0.436 0.397 0.401 1.45 0.636 3.41 -0.192 0.421 0.648 0.188 0.825 0.368 1.89 PRS_PLINK_1.99526231496888e.08 FALSE 610.2 Fibroadenosis of breast Female 6 17 11 genitourinary black 17, 6 4, 0 4, 0 4, 2 4, 1 -1.41 1.12 0.205 0.687 0.243 0.00185 1.6 -1.28 4.78 0.788 0.103 0.277 0.244 0.342 3.03 26.4 0.909 0.042 20.7 17.5 24.5 PRS_PLINK_1.99526231496888e.08 TRUE 610.4 Benign neoplasm of breast Female 189 440 11 genitourinary black 440, 189 54, 24 149, 63 70, 38 110, 44 0.075 0.0877 0.392 0.406 1.08 0.909 1.28 -0.0237 0.322 0.941 0.026 0.977 0.528 1.84 0.2 0.357 0.575 0.241 1.22 0.615 2.47 -0.065 0.322 0.84 0.076 0.937 0.505 1.77 PRS_PLINK_1.99526231496888e.08 FALSE 610.8 Other specified benign mammary dysplasias Female 64 263 11 genitourinary black 263, 64 29, 6 65, 20 65, 15 66, 15 0.0376 0.128 0.769 0.114 1.04 0.8 1.31 0.316 0.553 0.568 0.246 1.37 0.493 4.26 0.163 0.554 0.769 0.114 1.18 0.417 3.61 0.0349 0.566 0.951 0.022 1.04 0.354 3.3 PRS_PLINK_1.99526231496888e.08 FALSE 611 Abnormal findings on mammogram or breast exam Both 460 475 11 genitourinary black 475, 460 59, 57 156, 173 81, 90 118, 97 0.0309 0.0695 0.656 0.183 1.03 0.9 1.18 -0.059 0.249 0.812 0.09 0.943 0.581 1.53 0.0133 0.276 0.962 0.017 1.01 0.592 1.73 -0.342 0.254 0.178 0.749 0.71 0.433 1.16 PRS_PLINK_1.99526231496888e.08 FALSE 611.1 Abnormal mammogram Both 376 432 11 genitourinary black 432, 376 54, 47 142, 141 75, 73 107, 79 0.0395 0.0746 0.597 0.224 1.04 0.897 1.2 -0.128 0.273 0.638 0.195 0.879 0.517 1.49 0.0431 0.314 0.891 0.05 1.04 0.567 1.92 -0.363 0.277 0.191 0.719 0.696 0.406 1.19 PRS_PLINK_1.99526231496888e.08 FALSE 611.11 Mammographic microcalcification Both 70 148 11 genitourinary black 148, 70 15, 3 49, 28 25, 19 37, 13 0.121 0.131 0.355 0.45 1.13 0.878 1.44 0.983 0.715 0.169 0.772 2.67 0.754 12.3 0.986 0.746 0.186 0.729 2.68 0.695 12.8 0.113 0.729 0.877 0.057 1.12 0.287 5.01 PRS_PLINK_1.99526231496888e.08 FALSE 611.3 Lump or mass in breast Both 299 472 11 genitourinary black 472, 299 57, 38 158, 111 80, 59 116, 63 0.0637 0.0736 0.387 0.412 1.07 0.922 1.23 -0.0351 0.273 0.897 0.047 0.965 0.57 1.65 0.00349 0.305 0.991 0.004 1 0.555 1.82 -0.272 0.281 0.334 0.476 0.762 0.442 1.32 PRS_PLINK_1.99526231496888e.08 FALSE 612 Breast conditions, congenital or relating to hormones Both 111 315 11 genitourinary black 315, 111 38, 8 112, 52 44, 16 79, 23 0.0415 0.126 0.742 0.129 1.04 0.823 1.35 1.06 0.487 0.0294 1.532 2.89 1.17 8.07 0.449 0.527 0.394 0.405 1.57 0.577 4.5 0.437 0.483 0.365 0.437 1.55 0.627 4.18 PRS_PLINK_1.99526231496888e.08 FALSE 612.1 Galactorrhea Both 26 54 11 genitourinary black 54, 26 10, 2 12, 8 13, 9 14, 4 -0.0805 0.377 0.831 0.08 0.923 0.448 1.89 1.91 1.47 0.192 0.717 6.77 0.585 213 1.01 1.2 0.401 0.397 2.73 0.294 97.5 1.62 1.72 0.345 0.462 5.05 0.265 305 PRS_PLINK_1.99526231496888e.08 TRUE 612.2 Hypertrophy of breast (Gynecomastia) Both 73 209 11 genitourinary black 209, 73 30, 7 68, 28 36, 13 51, 15 0.0216 0.147 0.883 0.054 1.02 0.781 1.38 0.764 0.567 0.178 0.75 2.15 0.742 7.23 0.57 0.618 0.356 0.448 1.77 0.555 6.23 0.518 0.579 0.371 0.431 1.68 0.568 5.56 PRS_PLINK_1.99526231496888e.08 FALSE 612.3 Congenital anomalies of breast Both 8 23 11 genitourinary black 23, 8 5, 2 6, 5 5, 0 6, 1 -0.0747 0.594 0.9 0.046 0.928 0.213 2.75 0.574 1.63 0.725 0.14 1.78 0.0841 548 -1.46 1.96 0.455 0.342 0.232 0.000533 3.94 -2.27 2.27 0.316 0.5 0.103 0.000388 2.52 PRS_PLINK_1.99526231496888e.08 TRUE 613 Other nonmalignant breast conditions Both 320 728 11 genitourinary black 728, 320 102, 43 237, 121 127, 53 182, 70 -0.0856 0.0767 0.264 0.578 0.918 0.784 1.06 0.222 0.228 0.33 0.482 1.25 0.805 1.96 -0.0151 0.259 0.954 0.021 0.985 0.595 1.64 -0.112 0.243 0.645 0.19 0.894 0.56 1.44 PRS_PLINK_1.99526231496888e.08 FALSE 613.1 Inflammatory disease of breast Both 55 218 11 genitourinary black 218, 55 26, 5 72, 24 37, 10 54, 11 -0.091 0.176 0.606 0.217 0.913 0.629 1.26 0.866 0.606 0.153 0.815 2.38 0.796 8.72 0.694 0.629 0.27 0.569 2 0.621 7.32 -0.111 0.671 0.868 0.061 0.895 0.244 3.53 PRS_PLINK_1.99526231496888e.08 FALSE 613.5 Mastodynia Both 174 556 11 genitourinary black 556, 174 77, 27 181, 62 96, 27 137, 42 0.00517 0.0838 0.951 0.022 1.01 0.842 1.17 -0.0391 0.286 0.891 0.05 0.962 0.554 1.7 -0.224 0.328 0.494 0.306 0.799 0.421 1.52 -0.0694 0.298 0.816 0.088 0.933 0.526 1.68 PRS_PLINK_1.99526231496888e.08 FALSE 613.7 Other signs and symptoms in breast Both 93 319 11 genitourinary black 319, 93 46, 14 90, 29 68, 18 79, 22 0.0358 0.11 0.745 0.128 1.04 0.811 1.26 -0.153 0.401 0.703 0.153 0.858 0.396 1.9 -0.191 0.437 0.662 0.179 0.826 0.35 1.96 -0.0684 0.399 0.864 0.064 0.934 0.433 2.05 PRS_PLINK_1.99526231496888e.08 FALSE 613.8 Other specified disorders of breast Both 62 311 11 genitourinary black 311, 62 48, 8 105, 26 49, 10 77, 13 -0.168 0.181 0.353 0.452 0.845 0.577 1.18 0.307 0.435 0.481 0.318 1.36 0.598 3.34 0.168 0.557 0.763 0.117 1.18 0.388 3.71 0.0717 0.488 0.883 0.054 1.07 0.415 2.91 PRS_PLINK_1.99526231496888e.08 FALSE 613.9 Breast disorder NOS Both 95 396 11 genitourinary black 396, 95 63, 17 121, 30 73, 18 97, 18 -0.279 0.145 0.0541 1.267 0.756 0.563 0.998 -0.0566 0.355 0.873 0.059 0.945 0.476 1.92 -0.151 0.407 0.71 0.148 0.86 0.387 1.91 -0.337 0.39 0.388 0.412 0.714 0.333 1.53 PRS_PLINK_1.99526231496888e.08 FALSE 614 Inflammatory diseases of female pelvic organs Female 422 544 11 genitourinary black 544, 422 76, 54 184, 151 90, 51 134, 122 0.0711 0.0725 0.326 0.486 1.07 0.933 1.24 0.197 0.22 0.369 0.433 1.22 0.796 1.87 -0.207 0.254 0.416 0.381 0.813 0.497 1.33 0.303 0.225 0.178 0.749 1.35 0.878 2.1 PRS_PLINK_1.99526231496888e.08 FALSE 614.1 Pelvic peritoneal adhesions, female (postoperative) (postinfection) Female 41 110 11 genitourinary black 110, 41 18, 6 38, 11 16, 8 28, 12 0.206 0.264 0.436 0.361 1.23 0.744 2.06 -0.0617 0.614 0.92 0.036 0.94 0.307 3.11 0.345 0.672 0.607 0.217 1.41 0.41 5.11 0.471 0.652 0.47 0.328 1.6 0.472 6.26 PRS_PLINK_1.99526231496888e.08 TRUE 614.3 Pelvic inflammatory disease (PID) Female 68 187 11 genitourinary black 187, 68 24, 10 65, 28 30, 7 45, 14 -0.18 0.185 0.328 0.484 0.835 0.58 1.19 0.0698 0.45 0.877 0.057 1.07 0.463 2.6 -0.579 0.575 0.314 0.503 0.561 0.18 1.66 -0.329 0.533 0.536 0.271 0.719 0.256 2.03 PRS_PLINK_1.99526231496888e.08 FALSE 614.31 Acute inflammatory pelvic disease Female 17 45 11 genitourinary black 45, 17 7, 3 15, 7 7, 2 11, 2 -0.4 0.427 0.348 0.458 0.67 0.291 1.46 0.226 1.03 0.826 0.083 1.25 0.182 10.1 -0.9 1.49 0.547 0.262 0.406 5.88e-05 4.88 0.302 1.3 0.817 0.088 1.35 0.13 2940 PRS_PLINK_1.99526231496888e.08 TRUE 614.32 Chronic inflammatory pelvic disease Female 30 63 11 genitourinary black 63, 30 11, 4 16, 8 15, 5 16, 8 -0.291 0.314 0.354 0.451 0.748 0.407 1.34 0.456 0.827 0.582 0.235 1.58 0.353 8.01 -0.159 0.823 0.847 0.072 0.853 0.176 3.98 0.153 0.814 0.851 0.07 1.16 0.248 5.8 PRS_PLINK_1.99526231496888e.08 TRUE 614.33 Pelvic inflammatory disease, NOS Female 25 89 11 genitourinary black 89, 25 15, 4 26, 9 17, 3 22, 5 -0.442 0.309 0.153 0.816 0.643 0.348 1.16 0.209 0.748 0.78 0.108 1.23 0.306 5.54 -0.556 0.908 0.54 0.267 0.574 0.0882 3.11 -0.426 0.786 0.588 0.231 0.653 0.139 2.92 PRS_PLINK_1.99526231496888e.08 TRUE 614.4 Inflammatory diseases of uterus, except cervix Female 37 69 11 genitourinary black 69, 37 12, 10 18, 5 16, 6 17, 11 -0.158 0.287 0.582 0.235 0.854 0.492 1.47 -0.896 0.718 0.212 0.674 0.408 0.0988 1.49 -0.757 0.679 0.265 0.577 0.469 0.133 1.6 -0.211 0.644 0.742 0.129 0.809 0.243 2.67 PRS_PLINK_1.99526231496888e.08 TRUE 614.5 Inflammatory disease of cervix, vagina, and vulva Female 358 544 11 genitourinary black 544, 358 76, 47 184, 132 90, 41 134, 103 0.0749 0.0752 0.319 0.496 1.08 0.931 1.25 0.201 0.229 0.379 0.421 1.22 0.787 1.91 -0.279 0.268 0.299 0.524 0.757 0.45 1.27 0.255 0.234 0.276 0.558 1.29 0.823 2.04 PRS_PLINK_1.99526231496888e.08 FALSE 614.51 Cervicitis and endocervicitis Female 31 88 11 genitourinary black 88, 31 11, 5 26, 8 18, 5 22, 8 -0.115 0.299 0.701 0.154 0.892 0.499 1.58 -0.281 0.737 0.703 0.153 0.755 0.195 2.99 0.082 0.963 0.932 0.031 1.09 0.188 7.43 -0.581 0.801 0.468 0.329 0.56 0.124 2.45 PRS_PLINK_1.99526231496888e.08 TRUE 614.52 Vaginitis and vulvovaginitis Female 308 543 11 genitourinary black 543, 308 76, 37 184, 120 90, 32 133, 90 0.077 0.0806 0.339 0.469 1.08 0.923 1.26 0.332 0.244 0.173 0.762 1.39 0.873 2.26 -0.29 0.291 0.319 0.496 0.748 0.425 1.31 0.378 0.249 0.129 0.889 1.46 0.906 2.38 PRS_PLINK_1.99526231496888e.08 FALSE 614.53 Cyst or abscess of Bartholin's gland Female 15 54 11 genitourinary black 54, 15 11, 4 16, 4 9, 2 14, 4 -0.399 0.424 0.347 0.46 0.671 0.284 1.51 -0.759 1.05 0.471 0.327 0.468 0.0434 7.55 -0.283 1.12 0.801 0.096 0.753 0.0742 5.16 -0.278 0.942 0.767 0.115 0.757 0.126 4.24 PRS_PLINK_1.99526231496888e.08 TRUE 614.54 Abscess or ulceration of vulva Female 22 80 11 genitourinary black 80, 22 9, 2 24, 11 16, 4 20, 4 -0.116 0.325 0.72 0.142 0.89 0.47 1.7 0.614 0.876 0.483 0.316 1.85 0.382 11.5 -0.185 1.14 0.871 0.06 0.831 0.0739 8.09 -0.524 1.15 0.649 0.187 0.592 0.0497 5.55 PRS_PLINK_1.99526231496888e.08 TRUE 615 Endometriosis Female 147 476 11 genitourinary black 476, 147 74, 24 159, 44 78, 23 118, 41 0.168 0.0822 0.0417 1.38 1.18 1.01 1.39 -0.237 0.301 0.43 0.367 0.789 0.44 1.43 -0.243 0.344 0.479 0.32 0.784 0.399 1.53 0.0335 0.301 0.911 0.04 1.03 0.578 1.88 PRS_PLINK_1.99526231496888e.08 FALSE 618 Genital prolapse Female 108 618 11 genitourinary black 618, 108 93, 14 210, 35 96, 19 154, 26 -0.0676 0.118 0.568 0.246 0.935 0.725 1.16 0.0324 0.345 0.925 0.034 1.03 0.532 2.09 0.142 0.378 0.706 0.151 1.15 0.549 2.45 -0.103 0.365 0.778 0.109 0.902 0.445 1.88 PRS_PLINK_1.99526231496888e.08 FALSE 618.1 Prolapse of vaginal walls Female 51 378 11 genitourinary black 378, 51 67, 6 124, 17 63, 6 92, 16 0.0473 0.153 0.757 0.121 1.05 0.729 1.36 0.137 0.495 0.782 0.107 1.15 0.436 3.3 -0.00552 0.56 0.992 0.003 0.994 0.314 3.16 0.386 0.506 0.446 0.351 1.47 0.56 4.23 PRS_PLINK_1.99526231496888e.08 FALSE 618.2 Uterine/Uterovaginal prolapse Female 21 135 11 genitourinary black 135, 21 22, 4 44, 6 23, 3 34, 5 -0.34 0.323 0.293 0.532 0.712 0.375 1.34 -0.806 0.753 0.284 0.546 0.447 0.101 1.92 -0.863 0.986 0.381 0.419 0.422 0.0354 2.83 -0.639 0.946 0.499 0.302 0.528 0.0751 3.27 PRS_PLINK_1.99526231496888e.08 TRUE 618.5 Prolapse of vaginal vault after hysterectomy Female 3 63 11 genitourinary black 63, 3 12, 0 22, 2 9, 1 16, 0 0.447 0.753 0.553 0.258 1.56 0.249 11 1.06 1.46 0.466 0.332 2.89 0.173 566 0.86 1.41 0.542 0.266 2.36 0.121 6760 PRS_PLINK_1.99526231496888e.08 TRUE 618.6 Vaginal enterocele, congenital or acquired Female 17 131 11 genitourinary black 131, 17 20, 3 38, 3 27, 3 33, 4 -0.468 0.328 0.154 0.812 0.627 0.314 1.2 -0.56 0.838 0.504 0.297 0.571 0.0994 3.12 0.000654 0.879 0.999 0 1 0.172 6.56 -0.367 0.818 0.654 0.184 0.693 0.132 3.72 PRS_PLINK_1.99526231496888e.08 TRUE 619 Noninflammatory female genital disorders Female 590 432 11 genitourinary black 432, 590 53, 66 139, 229 78, 88 106, 152 0.144 0.0705 0.041 1.387 1.16 1.01 1.33 0.292 0.224 0.193 0.715 1.34 0.865 2.07 -0.111 0.247 0.654 0.184 0.895 0.555 1.44 0.117 0.233 0.614 0.212 1.12 0.715 1.76 PRS_PLINK_1.99526231496888e.08 FALSE 619.1 Noninflammatory disorders of ovary, fallopian tube, and broad ligament Female 168 336 11 genitourinary black 336, 168 39, 24 110, 64 58, 27 84, 37 0.133 0.109 0.221 0.656 1.14 0.925 1.41 -0.0157 0.323 0.961 0.017 0.984 0.531 1.85 -0.327 0.361 0.365 0.437 0.721 0.361 1.44 -0.271 0.339 0.423 0.373 0.762 0.399 1.47 PRS_PLINK_1.99526231496888e.08 FALSE 619.2 Disorders of uterus, NEC Female 95 153 11 genitourinary black 153, 95 22, 21 40, 20 36, 20 37, 24 0.0311 0.173 0.858 0.067 1.03 0.739 1.44 -0.625 0.44 0.155 0.81 0.535 0.231 1.22 -0.711 0.45 0.114 0.943 0.491 0.206 1.14 -0.378 0.443 0.393 0.406 0.685 0.294 1.58 PRS_PLINK_1.99526231496888e.08 FALSE 619.3 Noninflammatory disorders of cervix Female 59 143 11 genitourinary black 143, 59 19, 4 46, 18 26, 7 35, 20 0.172 0.206 0.405 0.393 1.19 0.801 1.77 0.76 0.674 0.26 0.585 2.14 0.629 8.88 0.17 0.701 0.808 0.092 1.19 0.32 4.84 1 0.66 0.128 0.892 2.73 0.829 10.7 PRS_PLINK_1.99526231496888e.08 FALSE 619.4 Noninflammatory disorders of vagina Female 295 429 11 genitourinary black 429, 295 52, 33 138, 116 77, 46 106, 71 0.0886 0.0899 0.325 0.489 1.09 0.917 1.3 0.309 0.27 0.252 0.599 1.36 0.811 2.31 -0.0936 0.302 0.757 0.121 0.911 0.509 1.63 0.0141 0.279 0.96 0.018 1.01 0.593 1.74 PRS_PLINK_1.99526231496888e.08 FALSE 619.5 Noninflammatory disorders of vulva and perineum Female 105 283 11 genitourinary black 283, 105 35, 16 90, 37 53, 13 68, 31 0.175 0.12 0.143 0.843 1.19 0.953 1.51 -0.0935 0.373 0.802 0.096 0.911 0.449 1.89 -0.685 0.44 0.119 0.923 0.504 0.212 1.17 -0.0796 0.382 0.835 0.078 0.924 0.446 1.94 PRS_PLINK_1.99526231496888e.08 FALSE 620 Dysplasia of female genital organs Female 29 139 11 genitourinary black 139, 29 22, 4 42, 12 26, 5 35, 7 -0.0428 0.298 0.886 0.053 0.958 0.533 1.74 0.454 0.651 0.485 0.314 1.58 0.471 6 -0.125 0.806 0.877 0.057 0.883 0.175 4.31 0.298 0.73 0.683 0.165 1.35 0.331 5.86 PRS_PLINK_1.99526231496888e.08 TRUE 620.1 Dysplasia of cervix Female 19 82 11 genitourinary black 82, 19 14, 3 24, 6 16, 5 21, 4 -0.415 0.379 0.273 0.563 0.66 0.31 1.36 -0.652 0.924 0.48 0.319 0.521 0.0837 3.12 -0.57 1.01 0.573 0.242 0.566 0.0633 3.61 0.0562 0.909 0.951 0.022 1.06 0.189 6.59 PRS_PLINK_1.99526231496888e.08 TRUE 621 Endometrial hyperplasia Female 48 144 11 genitourinary black 144, 48 19, 10 35, 13 37, 8 35, 10 -0.427 0.228 0.0609 1.215 0.653 0.416 1.01 -0.516 0.541 0.34 0.469 0.597 0.214 1.65 -0.62 0.576 0.282 0.55 0.538 0.179 1.62 -0.617 0.55 0.262 0.582 0.54 0.187 1.52 PRS_PLINK_1.99526231496888e.08 TRUE 622 Polyp of female genital organs Female 205 465 11 genitourinary black 465, 205 67, 32 145, 76 89, 25 112, 55 0.00645 0.0992 0.948 0.023 1.01 0.826 1.22 0.0958 0.268 0.72 0.142 1.1 0.659 1.86 -0.533 0.321 0.0965 1.016 0.587 0.314 1.09 0.0957 0.29 0.741 0.13 1.1 0.631 1.94 PRS_PLINK_1.99526231496888e.08 FALSE 622.1 Polyp of corpus uteri Female 170 367 11 genitourinary black 367, 170 52, 27 111, 64 72, 17 92, 48 -0.0252 0.107 0.815 0.089 0.975 0.786 1.19 0.0831 0.297 0.779 0.108 1.09 0.616 1.94 -0.776 0.366 0.0337 1.472 0.46 0.224 0.922 0.0263 0.315 0.934 0.03 1.03 0.561 1.9 PRS_PLINK_1.99526231496888e.08 FALSE 622.2 Mucous polyp of cervix Female 49 129 11 genitourinary black 129, 49 19, 12 37, 13 27, 9 32, 13 0.0444 0.228 0.846 0.073 1.05 0.674 1.64 -0.807 0.572 0.159 0.8 0.446 0.147 1.3 -0.783 0.609 0.199 0.702 0.457 0.138 1.4 -0.328 0.535 0.54 0.268 0.72 0.258 1.99 PRS_PLINK_1.99526231496888e.08 TRUE 623 Hypertrophy of female genital organs Female 72 288 11 genitourinary black 288, 72 34, 14 97, 27 47, 3 72, 23 0.138 0.0985 0.163 0.788 1.15 0.952 1.39 -0.454 0.404 0.261 0.584 0.635 0.293 1.4 -1.78 0.647 0.00589 2.23 0.168 0.0391 0.56 -0.269 0.404 0.505 0.297 0.764 0.353 1.68 PRS_PLINK_1.99526231496888e.08 FALSE 624 Symptoms involving female genital tract Female 170 337 11 genitourinary black 337, 170 42, 21 112, 70 57, 29 83, 39 0.000246 0.107 0.998 0.001 1 0.806 1.22 0.0625 0.325 0.848 0.072 1.06 0.571 2.01 0.00191 0.363 0.996 0.002 1 0.5 2.02 -0.191 0.344 0.578 0.238 0.826 0.427 1.61 PRS_PLINK_1.99526231496888e.08 FALSE 624.1 Dystrophy of female genital tract Female 12 27 11 genitourinary black 27, 12 1, 0 7, 5 6, 4 7, 3 0.703 0.517 0.174 0.76 2.02 0.834 5.78 4.71 4.45 0.289 0.538 111 0.316 162 -1.69 9.46 0.859 0.066 0.185 4.24e-08 765000 0.528 3.04 0.862 0.065 1.7 0.00622 416 PRS_PLINK_1.99526231496888e.08 TRUE 624.2 Atrophy of female genital tract Female 4 7 11 genitourinary black 7, 4 3, 3 2, 0 3, 3 2, 0 -0.66 1.96 0.737 0.133 0.517 0.464 3.74 PRS_PLINK_1.99526231496888e.08 TRUE 624.9 stress incontinence, female Female 126 319 11 genitourinary black 319, 126 39, 23 101, 43 58, 20 80, 31 -0.0579 0.123 0.639 0.195 0.944 0.73 1.19 -0.412 0.343 0.229 0.639 0.662 0.343 1.28 -0.492 0.396 0.214 0.669 0.611 0.283 1.3 -0.63 0.384 0.101 0.997 0.533 0.252 1.11 PRS_PLINK_1.99526231496888e.08 FALSE 625 Pain and other symptoms associated with female genital organs Female 554 392 11 genitourinary black 392, 554 50, 72 130, 194 65, 83 98, 150 0.0469 0.0673 0.486 0.313 1.05 0.922 1.2 -0.0728 0.229 0.751 0.125 0.93 0.594 1.45 -0.213 0.261 0.415 0.382 0.808 0.487 1.33 -0.0937 0.238 0.694 0.159 0.911 0.573 1.44 PRS_PLINK_1.99526231496888e.08 FALSE 625.1 Dyspareunia Female 107 334 11 genitourinary black 334, 107 41, 16 110, 43 56, 19 82, 19 0.0428 0.1 0.669 0.175 1.04 0.845 1.25 -0.245 0.38 0.519 0.284 0.783 0.379 1.64 -0.414 0.426 0.331 0.48 0.661 0.289 1.49 -0.551 0.402 0.171 0.768 0.576 0.265 1.26 PRS_PLINK_1.99526231496888e.08 FALSE 626 Disorders of menstruation and other abnormal bleeding from female genital tract Female 790 102 11 genitourinary black 102, 790 10, 94 26, 204 24, 170 26, 243 0.205 0.128 0.111 0.954 1.23 0.96 1.61 0.0338 0.391 0.931 0.031 1.03 0.456 2.22 -0.276 0.383 0.472 0.326 0.759 0.338 1.6 0.0306 0.378 0.936 0.029 1.03 0.464 2.15 PRS_PLINK_1.99526231496888e.08 FALSE 626.1 Irregular menstrual cycle/bleeding Female 652 98 11 genitourinary black 98, 652 9, 73 34, 236 14, 75 25, 205 0.192 0.133 0.147 0.832 1.21 0.942 1.6 -0.0174 0.393 0.965 0.016 0.983 0.429 2.08 -0.454 0.44 0.303 0.519 0.635 0.256 1.51 0.00496 0.4 0.99 0.004 1 0.432 2.18 PRS_PLINK_1.99526231496888e.08 FALSE 626.11 Absent or infrequent menstruation Female 243 78 11 genitourinary black 78, 243 9, 24 20, 64 18, 54 20, 81 0.24 0.163 0.14 0.855 1.27 0.951 1.8 0.281 0.484 0.562 0.25 1.32 0.511 3.3 -0.0658 0.491 0.893 0.049 0.936 0.354 2.35 0.384 0.472 0.416 0.381 1.47 0.578 3.59 PRS_PLINK_1.99526231496888e.08 FALSE 626.12 Excessive or frequent menstruation Female 277 91 11 genitourinary black 91, 277 9, 32 23, 83 22, 52 23, 81 0.0874 0.124 0.483 0.316 1.09 0.882 1.45 -0.049 0.454 0.914 0.039 0.952 0.384 2.23 -0.484 0.483 0.316 0.5 0.616 0.233 1.53 -0.226 0.456 0.621 0.207 0.798 0.319 1.87 PRS_PLINK_1.99526231496888e.08 FALSE 626.13 Irregular menstrual cycle Female 353 90 11 genitourinary black 90, 353 9, 38 22, 102 22, 68 23, 112 0.191 0.145 0.187 0.727 1.21 0.926 1.64 0.321 0.456 0.481 0.318 1.38 0.552 3.29 -0.298 0.45 0.508 0.294 0.742 0.297 1.75 0.131 0.439 0.765 0.116 1.14 0.465 2.63 PRS_PLINK_1.99526231496888e.08 FALSE 626.14 Irregular menstrual bleeding Female 137 71 11 genitourinary black 71, 137 9, 17 18, 39 17, 29 18, 39 0.0749 0.208 0.719 0.143 1.08 0.719 1.61 -0.0798 0.546 0.884 0.054 0.923 0.319 2.53 0.0744 0.59 0.9 0.046 1.08 0.349 3.32 -0.113 0.56 0.841 0.075 0.894 0.297 2.55 PRS_PLINK_1.99526231496888e.08 FALSE 626.15 Infertility, female, associated with anovulation Female 197 37 11 genitourinary black 37, 197 7, 36 10, 38 8, 26 9, 72 0.0718 0.152 0.637 0.196 1.07 0.833 1.56 -0.185 0.544 0.734 0.134 0.831 0.28 2.36 -0.589 0.596 0.324 0.49 0.555 0.171 1.73 0.306 0.535 0.567 0.246 1.36 0.45 3.91 PRS_PLINK_1.99526231496888e.08 FALSE 626.2 Dysmenorrhea Female 191 80 11 genitourinary black 80, 191 7, 18 22, 58 18, 37 20, 64 0.219 0.158 0.166 0.779 1.25 0.947 1.78 0.0904 0.524 0.863 0.064 1.09 0.386 2.91 -0.347 0.571 0.543 0.265 0.706 0.232 2.01 0.0415 0.525 0.937 0.028 1.04 0.369 2.74 PRS_PLINK_1.99526231496888e.08 FALSE 626.4 Premenstrual tension syndromes Female 50 27 11 genitourinary black 27, 50 5, 9 7, 13 6, 8 7, 17 0.512 0.359 0.154 0.813 1.67 0.855 3.39 0.1 0.933 0.915 0.039 1.11 0.172 6.64 -0.0917 0.917 0.92 0.036 0.912 0.17 4.8 0.487 0.786 0.536 0.271 1.63 0.386 7.14 PRS_PLINK_1.99526231496888e.08 TRUE 626.8 Infertility, female Female 364 66 11 genitourinary black 66, 364 7, 46 17, 94 15, 75 17, 106 0.0985 0.126 0.435 0.362 1.1 0.888 1.49 0.00663 0.487 0.989 0.005 1.01 0.368 2.57 -0.263 0.496 0.596 0.225 0.769 0.274 2.01 0.0329 0.477 0.945 0.025 1.03 0.379 2.61 PRS_PLINK_1.99526231496888e.08 FALSE 627 Menopausal and postmenopausal disorders Female 401 93 11 genitourinary black 93, 401 8, 41 23, 84 23, 108 23, 130 0.253 0.153 0.0988 1.005 1.29 0.954 1.74 -0.253 0.476 0.596 0.225 0.777 0.293 1.92 -0.319 0.463 0.49 0.31 0.727 0.281 1.74 0.0853 0.458 0.852 0.069 1.09 0.426 2.6 PRS_PLINK_1.99526231496888e.08 FALSE 627.1 Postmenopausal bleeding Female 90 48 11 genitourinary black 48, 90 3, 9 12, 22 12, 24 12, 28 0.156 0.242 0.519 0.285 1.17 0.735 1.87 -0.176 0.836 0.834 0.079 0.839 0.146 3.87 -1.15 0.906 0.203 0.693 0.315 0.0498 1.62 -0.627 0.883 0.477 0.321 0.534 0.0763 2.59 PRS_PLINK_1.99526231496888e.08 FALSE 627.2 Symptomatic menopause Female 265 79 11 genitourinary black 79, 265 8, 29 22, 65 17, 57 20, 87 0.193 0.168 0.249 0.604 1.21 0.877 1.7 -0.216 0.511 0.673 0.172 0.806 0.287 2.11 -0.394 0.517 0.446 0.351 0.674 0.235 1.78 0.0204 0.499 0.967 0.014 1.02 0.373 2.63 PRS_PLINK_1.99526231496888e.08 FALSE 627.21 Symptomatic artificial menopause Female 12 8 11 genitourinary black 8, 12 2, 4 2, 4 2, 0 2, 2 0.437 1.12 0.696 0.158 1.55 0.00916 101 -0.608 2.61 0.816 0.088 0.545 0.000721 205 1.03 13.2 0.938 0.028 2.79 5.63e-05 128000 1.05 3.82 0.782 0.107 2.87 0.000139 3.4 PRS_PLINK_1.99526231496888e.08 TRUE 627.22 Need for Hormone replacement therapy (postmenopausal) Female 32 14 11 genitourinary black 14, 32 2, 8 3, 4 4, 7 3, 9 0.297 0.505 0.557 0.254 1.35 0.531 3.59 -1.45 1.64 0.379 0.421 0.236 0.00955 3.02 -1.12 1.16 0.337 0.473 0.327 0.0186 2.4 -0.489 1.34 0.716 0.145 0.613 0.0212 6.82 PRS_PLINK_1.99526231496888e.08 TRUE 627.3 Postmenopausal atrophic vaginitis Female 54 53 11 genitourinary black 53, 54 5, 7 13, 13 13, 10 13, 21 0.389 0.287 0.174 0.759 1.48 0.863 2.58 0.103 0.964 0.915 0.038 1.11 0.199 6.76 -1.22 1.03 0.236 0.628 0.294 0.0317 1.94 -0.3 0.926 0.746 0.127 0.741 0.127 4.12 PRS_PLINK_1.99526231496888e.08 FALSE 627.4 Premenopausal menorrhagia Female 59 26 11 genitourinary black 26, 59 2, 3 7, 18 5, 13 7, 20 0.491 0.341 0.15 0.823 1.63 0.866 3.22 -0.233 1.43 0.871 0.06 0.792 0.0387 9.3 -0.028 1.3 0.983 0.008 0.972 0.0749 8.68 -1.28 1.7 0.453 0.344 0.278 0.00352 4.89 PRS_PLINK_1.99526231496888e.08 FALSE 627.5 Premature menopause and other ovarian failure Female 81 22 11 genitourinary black 22, 81 4, 15 5, 8 5, 22 6, 27 -0.164 0.352 0.641 0.193 0.848 0.422 1.66 -0.541 1.21 0.655 0.184 0.582 0.0465 5.98 0.025 0.818 0.976 0.011 1.03 0.202 5 -0.151 0.78 0.847 0.072 0.86 0.175 3.5 PRS_PLINK_1.99526231496888e.08 FALSE 628 Ovarian cyst Female 270 96 11 genitourinary black 96, 270 8, 29 25, 76 23, 59 24, 79 0.171 0.138 0.217 0.664 1.19 0.926 1.6 0.0196 0.475 0.967 0.014 1.02 0.393 2.49 -0.322 0.475 0.498 0.303 0.725 0.277 1.77 -0.0329 0.461 0.943 0.025 0.968 0.38 2.31 PRS_PLINK_1.99526231496888e.08 FALSE 634 Miscarriage; stillbirth Female 173 352 12 pregnancy complications royalblue4 352, 173 46, 18 125, 58 51, 30 88, 48 0.134 0.0837 0.109 0.963 1.14 0.978 1.35 0.0922 0.341 0.787 0.104 1.1 0.573 2.16 0.475 0.379 0.21 0.677 1.61 0.784 3.38 0.298 0.344 0.385 0.414 1.35 0.701 2.66 PRS_PLINK_1.99526231496888e.08 FALSE 634.1 Missed abortion/Hydatidiform mole Female 84 158 12 pregnancy complications royalblue4 158, 84 23, 16 51, 23 27, 13 40, 25 0.0661 0.108 0.539 0.268 1.07 0.868 1.31 -0.493 0.439 0.262 0.582 0.611 0.263 1.41 0.0642 0.521 0.902 0.045 1.07 0.402 2.89 -0.198 0.449 0.658 0.181 0.82 0.347 1.93 PRS_PLINK_1.99526231496888e.08 FALSE 634.3 Ectopic pregnancy Female 25 53 12 pregnancy complications royalblue4 53, 25 10, 3 14, 4 12, 8 13, 7 0.0626 0.29 0.829 0.081 1.06 0.612 1.81 0.824 1.11 0.458 0.339 2.28 0.359 25.1 0.702 0.949 0.459 0.338 2.02 0.347 13.3 0.559 0.96 0.56 0.251 1.75 0.325 13 PRS_PLINK_1.99526231496888e.08 TRUE 635 Hemorrhage during pregnancy; childbirth and postpartum Female 128 290 12 pregnancy complications royalblue4 290, 128 37, 23 102, 37 42, 27 73, 30 0.0719 0.0968 0.458 0.339 1.07 0.889 1.29 -0.488 0.346 0.158 0.801 0.614 0.316 1.2 0.0297 0.379 0.938 0.028 1.03 0.501 2.13 -0.359 0.356 0.314 0.503 0.699 0.352 1.39 PRS_PLINK_1.99526231496888e.08 FALSE 635.2 Antepartum hemorrhage, abruptio placentae, and placenta previa Female 84 198 12 pregnancy complications royalblue4 198, 84 22, 12 66, 27 32, 21 50, 16 0.0634 0.106 0.55 0.26 1.07 0.865 1.3 -0.171 0.454 0.707 0.15 0.843 0.358 2.05 0.261 0.481 0.588 0.231 1.3 0.53 3.28 -0.424 0.479 0.377 0.424 0.655 0.263 1.64 PRS_PLINK_1.99526231496888e.08 FALSE 635.3 Placenta previa and abruptio placenta Female 76 152 12 pregnancy complications royalblue4 152, 76 16, 15 53, 19 23, 17 38, 17 -0.0111 0.123 0.928 0.032 0.989 0.773 1.24 -0.958 0.469 0.0412 1.385 0.384 0.156 0.924 -0.218 0.525 0.678 0.169 0.804 0.301 2.14 -0.688 0.491 0.161 0.792 0.503 0.196 1.26 PRS_PLINK_1.99526231496888e.08 FALSE 636 Early or threatened labor; hemorrhage in early pregnancy Female 240 370 12 pregnancy complications royalblue4 370, 240 48, 33 134, 82 51, 46 92, 60 0.0774 0.082 0.345 0.462 1.08 0.926 1.27 -0.125 0.275 0.649 0.188 0.882 0.521 1.5 0.238 0.316 0.452 0.345 1.27 0.695 2.33 -0.114 0.288 0.692 0.16 0.892 0.513 1.56 PRS_PLINK_1.99526231496888e.08 FALSE 636.1 Threatened premature labor Female 85 210 12 pregnancy complications royalblue4 210, 85 26, 12 78, 28 25, 15 53, 24 0.0892 0.101 0.377 0.424 1.09 0.903 1.33 -0.303 0.426 0.477 0.322 0.738 0.33 1.69 0.44 0.505 0.384 0.416 1.55 0.61 4.09 -0.00366 0.452 0.994 0.003 0.996 0.424 2.41 PRS_PLINK_1.99526231496888e.08 FALSE 636.2 Early onset of delivery Female 50 151 12 pregnancy complications royalblue4 151, 50 21, 4 41, 11 33, 11 38, 22 0.241 0.171 0.16 0.796 1.27 0.939 1.81 0.524 0.69 0.447 0.35 1.69 0.477 7.03 0.494 0.656 0.452 0.345 1.64 0.488 6.42 1.06 0.613 0.0841 1.075 2.88 0.955 10.5 PRS_PLINK_1.99526231496888e.08 TRUE 636.3 Hemorrhage in early pregnancy Female 114 219 12 pregnancy complications royalblue4 219, 114 26, 11 57, 36 52, 22 55, 31 0.0803 0.157 0.608 0.216 1.08 0.801 1.47 0.439 0.443 0.321 0.494 1.55 0.679 3.71 -0.021 0.446 0.962 0.017 0.979 0.424 2.33 0.146 0.435 0.737 0.133 1.16 0.512 2.71 PRS_PLINK_1.99526231496888e.08 FALSE 636.8 Cervical incompetence Female 19 43 12 pregnancy complications royalblue4 43, 19 10, 7 13, 2 8, 2 11, 5 -0.815 0.472 0.084 1.076 0.442 0.173 1.09 -1.64 1.41 0.245 0.611 0.193 0.00322 2.29 -0.299 1.11 0.787 0.104 0.742 0.0875 5.07 -0.343 0.755 0.65 0.187 0.71 0.178 2.68 PRS_PLINK_1.99526231496888e.08 TRUE 637 Short gestation; low birth weight; and fetal growth retardation Both 6 23 12 pregnancy complications royalblue4 23, 6 2, 0 6, 1 6, 2 5, 3 0.268 0.483 0.579 0.238 1.31 0.585 3.16 -0.195 16.3 0.99 0.004 0.823 0.786 0.86 0.0569 3.94 0.988 0.005 1.06 0.00151 462 1.16 8.55 0.892 0.05 3.2 6.06e-06 829000 PRS_PLINK_1.99526231496888e.08 TRUE 642 Hypertension complicating pregnancy, childbirth, and the puerperium Female 131 389 12 pregnancy complications royalblue4 389, 131 60, 27 121, 33 74, 20 95, 36 -0.0671 0.105 0.524 0.28 0.935 0.744 1.13 -0.469 0.308 0.128 0.894 0.626 0.345 1.14 -0.444 0.348 0.201 0.696 0.641 0.325 1.25 -0.12 0.306 0.695 0.158 0.887 0.492 1.61 PRS_PLINK_1.99526231496888e.08 FALSE 642.1 Preeclampsia and eclampsia Female 64 207 12 pregnancy complications royalblue4 207, 64 33, 17 63, 14 40, 10 49, 17 -0.123 0.132 0.353 0.452 0.884 0.634 1.1 -0.766 0.428 0.0734 1.135 0.465 0.203 1.05 -0.648 0.474 0.172 0.766 0.523 0.207 1.28 -0.263 0.43 0.541 0.267 0.769 0.337 1.76 PRS_PLINK_1.99526231496888e.08 FALSE 643 Excessive vomiting in pregnancy Female 42 183 12 pregnancy complications royalblue4 183, 42 28, 6 58, 16 33, 9 46, 8 -0.085 0.184 0.643 0.192 0.919 0.608 1.26 0.292 0.539 0.588 0.23 1.34 0.487 4.06 0.364 0.587 0.535 0.272 1.44 0.464 4.67 0.0371 0.592 0.95 0.022 1.04 0.33 3.5 PRS_PLINK_1.99526231496888e.08 TRUE 643.1 Hyperemesis gravidarum Female 17 95 12 pregnancy complications royalblue4 95, 17 17, 3 29, 6 18, 3 24, 4 -0.0391 0.325 0.904 0.044 0.962 0.504 1.87 0.51 0.814 0.531 0.275 1.66 0.358 9.12 0.66 0.917 0.472 0.326 1.93 0.336 15.8 -0.104 0.859 0.903 0.044 0.901 0.153 5.02 PRS_PLINK_1.99526231496888e.08 TRUE 644 Anemia during pregnancy Female 54 173 12 pregnancy complications royalblue4 173, 54 24, 15 57, 15 29, 7 43, 10 -0.231 0.171 0.177 0.753 0.794 0.534 1.06 -1.07 0.466 0.0221 1.656 0.344 0.137 0.831 -1.33 0.642 0.0388 1.411 0.265 0.0678 0.859 -1.04 0.505 0.0397 1.401 0.354 0.13 0.908 PRS_PLINK_1.99526231496888e.08 FALSE 646 Other complications of pregnancy NEC Female 195 400 12 pregnancy complications royalblue4 400, 195 53, 29 128, 63 72, 42 100, 41 0.0102 0.0793 0.898 0.047 1.01 0.861 1.17 -0.164 0.29 0.573 0.242 0.849 0.487 1.49 0.0794 0.314 0.8 0.097 1.08 0.595 1.99 -0.319 0.303 0.293 0.534 0.727 0.406 1.3 PRS_PLINK_1.99526231496888e.08 FALSE 647 Infectious and parasitic complications affecting pregnancy Female 30 161 12 pregnancy complications royalblue4 161, 30 22, 2 51, 13 29, 9 39, 5 0.0782 0.199 0.695 0.158 1.08 0.687 1.53 0.672 0.754 0.373 0.429 1.96 0.496 10.8 1.35 0.806 0.0948 1.023 3.85 0.904 24 -0.121 0.83 0.884 0.053 0.886 0.171 5.87 PRS_PLINK_1.99526231496888e.08 TRUE 647.1 Infections of genitourinary tract during pregnancy Female 45 168 12 pregnancy complications royalblue4 168, 45 23, 7 43, 6 42, 18 41, 10 0.0118 0.13 0.927 0.033 1.01 0.738 1.25 -0.96 0.635 0.131 0.883 0.383 0.108 1.29 0.118 0.549 0.83 0.081 1.12 0.405 3.31 -0.177 0.574 0.758 0.12 0.838 0.283 2.56 PRS_PLINK_1.99526231496888e.08 TRUE 647.3 Major puerperal infection Female 17 53 12 pregnancy complications royalblue4 53, 17 11, 4 17, 5 8, 3 13, 2 -0.403 0.392 0.304 0.517 0.668 0.287 1.35 -0.403 0.85 0.636 0.197 0.669 0.136 3.69 0.133 1.19 0.911 0.041 1.14 0.12 12.1 -1.11 1.02 0.278 0.555 0.33 0.0365 1.94 PRS_PLINK_1.99526231496888e.08 TRUE 649 Other conditions or status of the mother complicating pregnancy, childbirth, or the puerperium Female 265 403 12 pregnancy complications royalblue4 403, 265 53, 37 144, 83 57, 35 101, 86 0.0598 0.0745 0.423 0.374 1.06 0.921 1.23 -0.211 0.262 0.421 0.376 0.81 0.489 1.35 -0.11 0.32 0.732 0.135 0.896 0.485 1.65 0.153 0.266 0.565 0.248 1.17 0.7 1.95 PRS_PLINK_1.99526231496888e.08 FALSE 649.1 Diabetes or abnormal glucose tolerance complicating pregnancy Female 113 284 12 pregnancy complications royalblue4 284, 113 40, 18 77, 23 64, 18 70, 43 0.0456 0.0867 0.599 0.223 1.05 0.882 1.23 -0.274 0.407 0.501 0.3 0.76 0.345 1.69 -0.325 0.417 0.436 0.36 0.723 0.324 1.61 0.239 0.359 0.505 0.297 1.27 0.644 2.55 PRS_PLINK_1.99526231496888e.08 FALSE 653 Problems associated with amniotic cavity and membranes Female 121 382 12 pregnancy complications royalblue4 382, 121 59, 25 120, 30 67, 26 95, 28 -0.0586 0.108 0.587 0.232 0.943 0.745 1.14 -0.505 0.319 0.113 0.947 0.604 0.326 1.12 -0.0591 0.345 0.864 0.063 0.943 0.484 1.84 -0.303 0.329 0.358 0.446 0.739 0.391 1.4 PRS_PLINK_1.99526231496888e.08 FALSE 654.1 Abnormality of organs and soft tissues of pelvis complicating pregnancy, childbirth, or the puerperium Female 56 141 12 pregnancy complications royalblue4 141, 56 23, 12 42, 13 27, 7 35, 16 -0.0503 0.2 0.801 0.096 0.951 0.647 1.4 -0.441 0.506 0.384 0.416 0.644 0.246 1.68 -0.315 0.572 0.581 0.236 0.729 0.244 2.13 0.017 0.497 0.973 0.012 1.02 0.4 2.63 PRS_PLINK_1.99526231496888e.08 FALSE 654.2 Rhesus isoimmunization in pregnancy Female 32 134 12 pregnancy complications royalblue4 134, 32 19, 8 37, 4 29, 6 34, 9 0.165 0.248 0.505 0.297 1.18 0.675 1.91 -0.868 0.683 0.204 0.691 0.42 0.104 1.59 -0.49 0.682 0.472 0.326 0.612 0.155 2.22 -0.0813 0.587 0.89 0.051 0.922 0.303 2.81 PRS_PLINK_1.99526231496888e.08 TRUE 655 Known or suspected fetal abnormality affecting management of mother Female 309 468 12 pregnancy complications royalblue4 468, 309 68, 40 116, 65 118, 94 115, 79 0.045 0.0719 0.531 0.275 1.05 0.91 1.2 -0.0194 0.267 0.942 0.026 0.981 0.587 1.65 0.317 0.249 0.203 0.693 1.37 0.853 2.23 0.0986 0.256 0.699 0.155 1.1 0.675 1.81 PRS_PLINK_1.99526231496888e.08 FALSE 655.1 Abnormality in fetal heart rate or rhythm Female 119 300 12 pregnancy complications royalblue4 300, 119 45, 22 95, 30 56, 29 74, 28 -0.0715 0.108 0.509 0.293 0.931 0.734 1.13 -0.475 0.347 0.171 0.766 0.622 0.32 1.21 0.00641 0.368 0.986 0.006 1.01 0.497 2.04 -0.503 0.37 0.174 0.76 0.605 0.295 1.23 PRS_PLINK_1.99526231496888e.08 FALSE 656 Other perinatal conditions of fetus or newborn Both 192 364 12 pregnancy complications royalblue4 364, 192 46, 28 126, 59 56, 39 91, 44 0.0394 0.0766 0.607 0.217 1.04 0.895 1.2 -0.319 0.298 0.284 0.546 0.727 0.41 1.3 0.145 0.327 0.659 0.181 1.16 0.62 2.17 -0.238 0.313 0.447 0.349 0.788 0.432 1.44 PRS_PLINK_1.99526231496888e.08 FALSE 656.2 Respiratory conditions of fetus and newborn Both 7 18 12 pregnancy complications royalblue4 18, 7 1, 0 4, 1 4, 1 5, 4 0.265 0.207 0.201 0.696 1.3 0.953 2.1 -0.241 3490 1 0 0.786 0.127 26.4 -0.0163 1580 1 0 0.984 0.684 1.39 3.17 4.49 0.481 0.318 23.7 0.0511 35400 PRS_PLINK_1.99526231496888e.08 TRUE 669 Complications of labor and delivery NEC Female 192 418 12 pregnancy complications royalblue4 418, 192 59, 45 136, 41 73, 29 104, 55 0.0497 0.078 0.524 0.28 1.05 0.902 1.22 -0.896 0.274 0.00106 2.976 0.408 0.24 0.69 -0.556 0.303 0.0661 1.18 0.574 0.319 1.02 -0.373 0.266 0.16 0.795 0.689 0.412 1.15 PRS_PLINK_1.99526231496888e.08 FALSE 671 Venous/cerebrovascular complications embolism in pregnancy and the puerperium Female 29 128 12 pregnancy complications royalblue4 128, 29 11, 3 41, 8 24, 6 31, 8 0.188 0.258 0.466 0.331 1.21 0.733 2.04 -0.139 0.836 0.868 0.061 0.87 0.188 4.6 0.279 0.939 0.766 0.116 1.32 0.204 8.66 0.175 0.915 0.848 0.072 1.19 0.223 7.23 PRS_PLINK_1.99526231496888e.08 TRUE 674 Other complications of the puerperium NEC Female 30 90 12 pregnancy complications royalblue4 90, 30 7, 1 26, 9 18, 3 23, 11 -0.00597 0.118 0.96 0.018 0.994 0.786 1.22 -0.116 1.14 0.919 0.036 0.891 0.0783 10.8 -0.033 1.33 0.98 0.009 0.968 0.0446 164 0.817 1.11 0.46 0.337 2.26 0.337 25.2 PRS_PLINK_1.99526231496888e.08 TRUE 676 Other disorders of the breast associated with childbirth and disorders of lactation Female 55 148 12 pregnancy complications royalblue4 148, 55 18, 9 38, 15 35, 12 37, 17 0.213 0.213 0.318 0.498 1.24 0.822 1.88 -0.358 0.535 0.504 0.298 0.699 0.256 1.93 -0.381 0.546 0.485 0.314 0.683 0.245 1.92 -0.396 0.557 0.477 0.321 0.673 0.231 1.94 PRS_PLINK_1.99526231496888e.08 FALSE 681 Superficial cellulitis and abscess Both 314 858 13 dermatologic firebrick 858, 314 118, 39 272, 125 156, 47 213, 80 0.0311 0.0647 0.631 0.2 1.03 0.906 1.17 0.253 0.221 0.253 0.597 1.29 0.842 2 -0.134 0.257 0.603 0.22 0.875 0.53 1.45 0.0844 0.231 0.715 0.145 1.09 0.696 1.72 PRS_PLINK_1.99526231496888e.08 FALSE 681.1 Cellulitis and abscess of fingers/toes Both 77 271 13 dermatologic firebrick 271, 77 36, 7 94, 36 42, 7 67, 22 0.0115 0.123 0.925 0.034 1.01 0.769 1.25 0.564 0.459 0.219 0.659 1.76 0.753 4.55 -0.00824 0.587 0.989 0.005 0.992 0.31 3.22 0.295 0.482 0.541 0.267 1.34 0.543 3.59 PRS_PLINK_1.99526231496888e.08 FALSE 681.2 Cellulitis and abscess of face/neck Both 59 194 13 dermatologic firebrick 194, 59 30, 7 58, 25 36, 6 48, 18 0.183 0.142 0.198 0.703 1.2 0.925 1.6 0.451 0.496 0.363 0.44 1.57 0.627 4.26 -0.401 0.65 0.537 0.27 0.669 0.181 2.37 0.465 0.538 0.387 0.412 1.59 0.585 4.72 PRS_PLINK_1.99526231496888e.08 FALSE 681.3 Cellulitis and abscess of arm/hand Both 107 390 13 dermatologic firebrick 390, 107 48, 15 136, 45 58, 11 98, 30 0.0844 0.0966 0.382 0.418 1.09 0.894 1.3 -0.102 0.353 0.773 0.112 0.903 0.462 1.82 -0.684 0.463 0.14 0.854 0.505 0.201 1.22 -0.129 0.377 0.733 0.135 0.879 0.427 1.85 PRS_PLINK_1.99526231496888e.08 FALSE 681.5 Cellulitis and abscess of leg, except foot Both 103 394 13 dermatologic firebrick 394, 103 50, 15 130, 39 65, 13 99, 28 0.0428 0.0957 0.655 0.184 1.04 0.852 1.24 -0.113 0.357 0.751 0.124 0.893 0.453 1.81 -0.373 0.427 0.382 0.418 0.688 0.298 1.57 -0.15 0.377 0.69 0.161 0.86 0.417 1.81 PRS_PLINK_1.99526231496888e.08 FALSE 681.6 Cellulitis and abscess of foot, toe Both 84 319 13 dermatologic firebrick 319, 84 39, 10 115, 31 43, 11 80, 25 0.112 0.106 0.29 0.537 1.12 0.908 1.36 0.0155 0.416 0.97 0.013 1.02 0.464 2.36 -0.115 0.513 0.822 0.085 0.891 0.326 2.4 0.129 0.433 0.766 0.116 1.14 0.499 2.71 PRS_PLINK_1.99526231496888e.08 FALSE 681.7 Cellulitis and abscess of trunk Both 70 336 13 dermatologic firebrick 336, 70 47, 13 100, 23 67, 9 83, 14 -0.122 0.142 0.391 0.408 0.885 0.646 1.14 -0.188 0.398 0.636 0.196 0.828 0.386 1.83 -0.685 0.475 0.149 0.826 0.504 0.194 1.26 -0.306 0.442 0.488 0.312 0.736 0.309 1.77 PRS_PLINK_1.99526231496888e.08 FALSE 686 Other local infections of skin and subcutaneous tissue Both 116 429 13 dermatologic firebrick 429, 116 49, 10 145, 43 71, 20 105, 30 0.0774 0.0926 0.404 0.394 1.08 0.894 1.28 0.364 0.397 0.359 0.445 1.44 0.683 3.25 0.405 0.452 0.371 0.431 1.5 0.639 3.74 0.211 0.405 0.603 0.22 1.23 0.571 2.82 PRS_PLINK_1.99526231496888e.08 FALSE 686.1 Carbuncle and furuncle Both 43 135 13 dermatologic firebrick 135, 43 17, 0 45, 24 23, 9 33, 7 0.0134 0.224 0.952 0.021 1.01 0.652 1.55 3.07 1.38 0.0261 1.584 21.6 2.64 2830 2.64 1.38 0.0555 1.256 14 1.33 1840 2.59 1.54 0.0931 1.031 13.4 0.993 1e+05 PRS_PLINK_1.99526231496888e.08 TRUE 686.2 Impetigo Both 30 127 13 dermatologic firebrick 127, 30 20, 4 36, 10 28, 6 31, 8 0.108 0.276 0.694 0.158 1.11 0.658 1.93 0.471 0.704 0.504 0.298 1.6 0.439 6.69 0.47 0.782 0.547 0.262 1.6 0.373 8.49 0.382 0.765 0.617 0.21 1.47 0.336 7.21 PRS_PLINK_1.99526231496888e.08 TRUE 686.3 Pilonidal cyst Both 5 56 13 dermatologic firebrick 56, 5 5, 0 14, 3 14, 0 14, 1 0.0206 0.29 0.944 0.025 1.02 0.235 1.6 0.585 2.22 0.792 0.101 1.79 0.0258 2700 0.708 2.2 0.748 0.126 2.03 0.00584 1800 PRS_PLINK_1.99526231496888e.08 TRUE 686.4 Pyogenic granuloma Both 13 37 13 dermatologic firebrick 37, 13 3, 2 10, 4 8, 1 9, 5 0.0846 0.442 0.848 0.071 1.09 0.463 2.55 -1.21 2.82 0.668 0.175 0.298 6.07e-07 22.4 -0.898 3.21 0.779 0.108 0.407 0.000118 146 -0.352 1.5 0.815 0.089 0.704 0.01 12.7 PRS_PLINK_1.99526231496888e.08 TRUE 686.5 Pyoderma Both 0 18 13 dermatologic firebrick 18, 0 PRS_PLINK_1.99526231496888e.08 TRUE 687 Symptoms affecting skin Both 100 296 13 dermatologic firebrick 296, 100 46, 8 102, 36 46, 16 73, 29 0.131 0.0909 0.15 0.823 1.14 0.958 1.36 0.659 0.431 0.126 0.901 1.93 0.865 4.74 0.548 0.495 0.268 0.572 1.73 0.677 4.68 0.678 0.434 0.119 0.926 1.97 0.875 4.82 PRS_PLINK_1.99526231496888e.08 FALSE 687.1 Rash and other nonspecific skin eruption Both 448 618 13 dermatologic firebrick 618, 448 96, 53 212, 156 94, 70 153, 117 0.0431 0.0628 0.492 0.308 1.04 0.923 1.18 0.307 0.214 0.151 0.82 1.36 0.9 2.07 0.296 0.244 0.224 0.65 1.34 0.841 2.16 0.343 0.222 0.122 0.914 1.41 0.92 2.18 PRS_PLINK_1.99526231496888e.08 FALSE 687.3 Changes in skin texture Both 20 79 13 dermatologic firebrick 79, 20 10, 0 21, 7 18, 3 20, 9 0.194 0.156 0.212 0.673 1.21 0.942 1.71 1.8 1.41 0.202 0.695 6.03 0.582 784 0.857 1.46 0.556 0.255 2.36 0.127 22200 1.94 1.32 0.143 0.844 6.94 0.82 730 PRS_PLINK_1.99526231496888e.08 TRUE 687.4 Disturbance of skin sensation Both 349 618 13 dermatologic firebrick 618, 349 96, 34 212, 134 92, 53 155, 91 -0.0159 0.0769 0.836 0.078 0.984 0.843 1.14 0.556 0.236 0.0187 1.729 1.74 1.11 2.79 0.441 0.28 0.115 0.938 1.55 0.906 2.69 0.493 0.249 0.0478 1.32 1.64 1.01 2.68 PRS_PLINK_1.99526231496888e.08 FALSE 689 Disorder of skin and subcutaneous tissue NOS Both 490 776 13 dermatologic firebrick 776, 490 120, 66 256, 164 130, 68 193, 136 0.0752 0.0596 0.207 0.683 1.08 0.961 1.21 0.0883 0.195 0.65 0.187 1.09 0.749 1.6 -0.0244 0.227 0.915 0.039 0.976 0.628 1.52 0.249 0.2 0.214 0.669 1.28 0.87 1.9 PRS_PLINK_1.99526231496888e.08 FALSE 690 Erythematosquamous dermatosis Both 270 600 13 dermatologic firebrick 600, 270 78, 32 209, 110 91, 40 150, 67 0.0957 0.0839 0.254 0.595 1.1 0.933 1.29 0.205 0.259 0.428 0.368 1.23 0.747 2.05 -0.00139 0.295 0.996 0.002 0.999 0.564 1.77 -0.0281 0.268 0.917 0.038 0.972 0.58 1.64 PRS_PLINK_1.99526231496888e.08 FALSE 690.1 Seborrheic dermatitis Both 270 599 13 dermatologic firebrick 599, 270 78, 31 209, 111 92, 40 148, 67 0.0976 0.0839 0.245 0.611 1.1 0.935 1.3 0.26 0.261 0.32 0.495 1.3 0.786 2.18 0.0207 0.297 0.944 0.025 1.02 0.574 1.82 0.0236 0.27 0.93 0.031 1.02 0.608 1.74 PRS_PLINK_1.99526231496888e.08 FALSE 691 Congenital anomalies of skin Both 39 162 13 dermatologic firebrick 162, 39 23, 6 53, 10 27, 6 41, 11 0.1 0.175 0.568 0.246 1.11 0.784 1.54 -0.365 0.601 0.543 0.265 0.694 0.22 2.32 -0.101 0.648 0.876 0.058 0.904 0.258 3.12 -0.0321 0.599 0.957 0.019 0.968 0.312 3.16 PRS_PLINK_1.99526231496888e.08 TRUE 691.3 Congenital pigmentary anomalies of skin Both 8 25 13 dermatologic firebrick 25, 8 4, 0 7, 3 5, 2 6, 2 0.0159 0.816 0.984 0.007 1.02 0.189 5.02 3.02 3.08 0.327 0.486 20.4 0.142 58800 1.56 2.4 0.515 0.288 4.77 0.197 460 -4.56 7.95 0.566 0.247 0.0105 1.6e-11 988 PRS_PLINK_1.99526231496888e.08 TRUE 694 Dyschromia and Vitiligo Both 134 356 13 dermatologic firebrick 356, 134 40, 16 89, 34 88, 34 89, 39 0.115 0.101 0.252 0.598 1.12 0.921 1.36 -0.0933 0.372 0.802 0.096 0.911 0.449 1.89 -0.146 0.371 0.694 0.159 0.864 0.426 1.78 -0.0929 0.374 0.804 0.095 0.911 0.445 1.9 PRS_PLINK_1.99526231496888e.08 FALSE 694.1 Vitiligo Both 8 33 13 dermatologic firebrick 33, 8 3, 0 10, 2 6, 1 8, 4 1.4 0.719 0.052 1.284 4.05 1.2 31.3 0.631 2.21 0.775 0.111 1.88 0.00665 274 1.79 6.04 0.767 0.115 5.97 0.000599 61200 -0.781 2.53 0.757 0.121 0.458 0.00586 11800 PRS_PLINK_1.99526231496888e.08 TRUE 694.2 Other dyschromia Both 124 328 13 dermatologic firebrick 328, 124 39, 15 107, 43 58, 17 81, 38 0.125 0.114 0.272 0.566 1.13 0.909 1.41 -0.0574 0.368 0.876 0.057 0.944 0.47 1.95 -0.289 0.417 0.488 0.311 0.749 0.334 1.68 0.0108 0.386 0.978 0.01 1.01 0.482 2.17 PRS_PLINK_1.99526231496888e.08 FALSE 694.3 Vascular disorders of skin Both 5 13 13 dermatologic firebrick 13, 5 2, 1 3, 1 3, 1 3, 2 0.41 0.812 0.614 0.212 1.51 0.373 12.5 -3.14 23.6 0.894 0.049 0.0432 0.026 0.0471 -0.82 268 0.998 0.001 0.441 0.0284 0.284 0.0544 5.36 0.992 0.004 1.06 1 1.12 PRS_PLINK_1.99526231496888e.08 TRUE 695 Erythematous conditions Both 243 663 13 dermatologic firebrick 663, 243 90, 23 228, 84 106, 31 163, 78 0.189 0.0699 0.00694 2.158 1.21 1.06 1.39 0.439 0.282 0.119 0.924 1.55 0.907 2.73 0.159 0.325 0.624 0.205 1.17 0.622 2.24 0.651 0.281 0.0203 1.692 1.92 1.12 3.37 PRS_PLINK_1.99526231496888e.08 FALSE 695.1 Toxic erythema Both 8 16 13 dermatologic firebrick 16, 8 2, 0 7, 0 1, 1 4, 5 0.6 0.381 0.115 0.938 1.82 1.04 4.73 0.0205 950 1 0 1.02 0.485 1.74 0.708 2.81 0.801 0.096 2.03 0.0757 2.35 PRS_PLINK_1.99526231496888e.08 TRUE 695.2 Bullous dermatoses Both 3 9 13 dermatologic firebrick 9, 3 0.386 0.798 0.628 0.202 1.47 0.457 8.55 PRS_PLINK_1.99526231496888e.08 TRUE 695.3 Rosacea Both 129 347 13 dermatologic firebrick 347, 129 42, 9 87, 36 86, 26 87, 41 0.187 0.114 0.102 0.992 1.21 0.974 1.52 0.677 0.428 0.114 0.944 1.97 0.887 4.72 0.296 0.435 0.497 0.304 1.34 0.593 3.26 0.771 0.416 0.0634 1.198 2.16 0.996 5.09 PRS_PLINK_1.99526231496888e.08 FALSE 695.4 Lupus (localized and systemic) Both 39 146 13 dermatologic firebrick 146, 39 20, 6 36, 5 36, 11 37, 14 0.423 0.254 0.0962 1.017 1.53 0.938 2.55 -0.698 0.883 0.429 0.368 0.497 0.0752 2.92 -0.525 0.663 0.429 0.368 0.592 0.154 2.16 0.516 0.609 0.397 0.401 1.68 0.547 5.63 PRS_PLINK_1.99526231496888e.08 TRUE 695.41 Cutaneous lupus erythematosus Both 22 62 13 dermatologic firebrick 62, 22 10, 3 17, 2 13, 7 16, 8 0.308 0.359 0.391 0.408 1.36 0.698 2.75 -1.29 1.66 0.436 0.361 0.274 1.78e-07 5.81 0.188 0.949 0.843 0.074 1.21 0.209 7 0.81 0.984 0.41 0.387 2.25 0.412 15.2 PRS_PLINK_1.99526231496888e.08 TRUE 695.42 Systemic lupus erythematosus Both 36 139 13 dermatologic firebrick 139, 36 18, 6 42, 7 27, 8 35, 12 0.358 0.261 0.171 0.768 1.43 0.864 2.43 -0.954 0.817 0.243 0.614 0.385 0.0701 1.95 -0.413 0.69 0.549 0.26 0.662 0.171 2.48 0.325 0.631 0.606 0.217 1.38 0.428 4.84 PRS_PLINK_1.99526231496888e.08 TRUE 695.7 Prurigo and Lichen Both 24 105 13 dermatologic firebrick 105, 24 9, 4 34, 5 19, 3 25, 8 -0.126 0.287 0.661 0.18 0.882 0.499 1.55 -1.11 0.885 0.21 0.677 0.33 0.0587 1.73 -0.858 0.999 0.39 0.408 0.424 0.0595 2.37 -0.276 0.849 0.745 0.128 0.759 0.139 3.79 PRS_PLINK_1.99526231496888e.08 TRUE 695.8 Other specified erythematous conditions Both 49 177 13 dermatologic firebrick 177, 49 17, 4 57, 22 30, 10 44, 9 0.158 0.144 0.27 0.569 1.17 0.882 1.53 0.808 0.702 0.249 0.603 2.24 0.641 10.1 0.155 0.722 0.83 0.081 1.17 0.298 5.02 -0.254 0.696 0.715 0.146 0.775 0.205 3.15 PRS_PLINK_1.99526231496888e.08 TRUE 695.81 Erythema nodosum Both 4 24 13 dermatologic firebrick 24, 4 2, 0 9, 1 3, 0 6, 2 -0.198 0.737 0.789 0.103 0.821 0.176 3.35 -0.531 5.11 0.917 0.037 0.588 0.517 0.719 1.8 2.84 0.526 0.279 6.05 0.139 1330 PRS_PLINK_1.99526231496888e.08 TRUE 695.9 Unspecified erythematous condition Both 32 125 13 dermatologic firebrick 125, 32 15, 2 34, 11 28, 2 31, 11 0.203 0.158 0.2 0.7 1.23 0.958 1.84 1.93 1.03 0.0602 1.22 6.92 1.15 70.2 -0.406 0.944 0.667 0.176 0.667 0.0762 4.86 0.676 0.888 0.446 0.35 1.97 0.375 14.5 PRS_PLINK_1.99526231496888e.08 TRUE 696 Psoriasis and related disorders Both 60 303 13 dermatologic firebrick 303, 60 39, 9 82, 18 68, 15 76, 13 -0.0151 0.166 0.927 0.033 0.985 0.692 1.33 -0.187 0.48 0.697 0.157 0.829 0.332 2.17 -0.148 0.473 0.754 0.123 0.862 0.347 2.21 -0.336 0.483 0.487 0.312 0.715 0.28 1.89 PRS_PLINK_1.99526231496888e.08 FALSE 696.3 Pityriasis Both 5 19 13 dermatologic firebrick 19, 5 5, 3 5, 2 4, 0 5, 0 -0.231 0.427 0.589 0.23 0.794 0.0363 1.36 -0.839 1.52 0.581 0.236 0.432 0.0214 5.17 -0.428 2.01 0.831 0.08 0.652 0.00352 45.8 -1.7 1.88 0.366 0.437 0.182 4.05e-07 3.23 PRS_PLINK_1.99526231496888e.08 TRUE 696.4 Psoriasis Both 54 275 13 dermatologic firebrick 275, 54 35, 7 77, 17 61, 13 67, 13 0.144 0.193 0.456 0.341 1.15 0.788 1.69 -0.169 0.508 0.739 0.131 0.844 0.321 2.36 0.00415 0.519 0.994 0.003 1 0.372 2.85 -0.128 0.508 0.801 0.096 0.88 0.332 2.47 PRS_PLINK_1.99526231496888e.08 FALSE 696.41 Psoriasis vulgaris Both 51 250 13 dermatologic firebrick 250, 51 31, 6 69, 17 55, 12 63, 13 0.19 0.202 0.347 0.46 1.21 0.81 1.8 -0.144 0.536 0.788 0.103 0.866 0.313 2.56 -0.231 0.554 0.676 0.17 0.794 0.271 2.4 -0.0431 0.549 0.937 0.028 0.958 0.336 2.92 PRS_PLINK_1.99526231496888e.08 FALSE 696.42 Psoriatic arthropathy Both 6 64 13 dermatologic firebrick 64, 6 10, 2 19, 2 13, 1 16, 1 -0.356 0.601 0.554 0.256 0.701 0.201 2.34 1.52 1.77 0.389 0.41 4.58 0.199 69600000 -1.56 1.68 0.352 0.453 0.21 0.00033 4.65 -0.648 1.38 0.639 0.194 0.523 0.00285 8.81 PRS_PLINK_1.99526231496888e.08 TRUE 697 Sarcoidosis Both 13 60 13 dermatologic firebrick 60, 13 9, 5 15, 4 15, 3 15, 1 -0.663 0.427 0.12 0.92 0.515 0.213 1.15 -2.03 1.21 0.0924 1.034 0.131 0.0026 1 -1.7 1.31 0.193 0.715 0.182 0.00447 1.62 -2.51 1.39 0.0709 1.15 0.0817 0.000322 0.821 PRS_PLINK_1.99526231496888e.08 TRUE 698 Pruritus and related conditions Both 179 703 13 dermatologic firebrick 703, 179 98, 24 247, 64 104, 25 174, 56 0.148 0.0722 0.0399 1.399 1.16 1.01 1.33 0.102 0.273 0.709 0.149 1.11 0.655 1.92 0.106 0.324 0.743 0.129 1.11 0.589 2.11 0.192 0.276 0.487 0.313 1.21 0.712 2.1 PRS_PLINK_1.99526231496888e.08 FALSE 700 Corns and callosities Both 86 214 13 dermatologic firebrick 214, 86 33, 9 68, 34 38, 5 53, 30 -0.00409 0.0994 0.967 0.015 0.996 0.802 1.18 0.481 0.443 0.277 0.557 1.62 0.707 3.97 -0.513 0.628 0.414 0.383 0.599 0.164 1.96 0.694 0.45 0.123 0.91 2 0.871 4.92 PRS_PLINK_1.99526231496888e.08 FALSE 701 Other hypertrophic and atrophic conditions of skin Both 433 787 13 dermatologic firebrick 787, 433 114, 90 241, 134 152, 68 194, 97 -0.0847 0.0653 0.195 0.711 0.919 0.804 1.04 -0.421 0.186 0.024 1.62 0.657 0.457 0.943 -0.556 0.212 0.00871 2.06 0.573 0.379 0.864 -0.504 0.197 0.0105 1.979 0.604 0.411 0.885 PRS_PLINK_1.99526231496888e.08 FALSE 701.1 Keratoderma, acquired Both 31 113 13 dermatologic firebrick 113, 31 20, 5 33, 11 22, 2 28, 12 0.285 0.286 0.32 0.495 1.33 0.767 2.37 0.387 0.657 0.556 0.255 1.47 0.44 5.51 -0.854 0.944 0.366 0.437 0.426 0.0387 3.24 0.524 0.659 0.427 0.37 1.69 0.495 6.25 PRS_PLINK_1.99526231496888e.08 TRUE 701.2 Scar conditions and fibrosis of skin Both 103 450 13 dermatologic firebrick 450, 103 65, 12 149, 36 74, 15 112, 28 0.0134 0.103 0.897 0.047 1.01 0.811 1.22 0.303 0.372 0.415 0.382 1.35 0.668 2.9 0.283 0.438 0.517 0.286 1.33 0.566 3.18 0.416 0.386 0.281 0.551 1.52 0.724 3.33 PRS_PLINK_1.99526231496888e.08 FALSE 701.3 Circumscribed scleroderma Both 27 125 13 dermatologic firebrick 125, 27 18, 9 31, 4 31, 7 31, 4 0.108 0.206 0.601 0.221 1.11 0.747 1.66 -1.11 0.689 0.107 0.969 0.33 0.0825 1.2 -0.388 0.682 0.569 0.245 0.678 0.183 2.53 -1.41 0.754 0.0619 1.209 0.245 0.0488 0.996 PRS_PLINK_1.99526231496888e.08 TRUE 701.4 Keloid scar Both 33 167 13 dermatologic firebrick 167, 33 22, 7 50, 10 34, 7 41, 8 0.296 0.205 0.149 0.828 1.34 0.934 2.08 -0.677 0.594 0.254 0.595 0.508 0.162 1.6 -0.255 0.649 0.694 0.158 0.775 0.22 2.77 -0.824 0.689 0.232 0.635 0.439 0.108 1.65 PRS_PLINK_1.99526231496888e.08 TRUE 701.5 Abnormal granulation tissue Both 19 83 13 dermatologic firebrick 83, 19 10, 6 32, 7 9, 3 21, 3 -0.132 0.344 0.701 0.154 0.877 0.444 1.72 -2.49 0.946 0.00853 2.069 0.083 0.01 0.453 -0.479 1.01 0.635 0.197 0.619 0.086 3.93 -1.59 0.875 0.0698 1.156 0.205 0.0195 1.02 PRS_PLINK_1.99526231496888e.08 TRUE 702 Degenerative skin conditions and other dermatoses Both 315 512 13 dermatologic firebrick 512, 315 77, 41 152, 127 104, 54 128, 61 -0.106 0.091 0.245 0.61 0.9 0.743 1.06 0.294 0.258 0.254 0.596 1.34 0.816 2.22 -0.171 0.283 0.546 0.263 0.843 0.486 1.46 -0.218 0.285 0.444 0.352 0.804 0.462 1.4 PRS_PLINK_1.99526231496888e.08 FALSE 702.1 Actinic keratosis Both 132 377 13 dermatologic firebrick 377, 132 63, 19 114, 57 74, 20 92, 25 -0.153 0.135 0.257 0.59 0.858 0.649 1.1 0.466 0.328 0.155 0.81 1.59 0.855 3.06 -0.0169 0.391 0.965 0.015 0.983 0.462 2.11 -0.276 0.376 0.463 0.334 0.759 0.365 1.58 PRS_PLINK_1.99526231496888e.08 FALSE 702.2 Seborrheic keratosis Both 270 625 13 dermatologic firebrick 625, 270 99, 36 187, 109 122, 45 154, 54 -0.103 0.0912 0.259 0.586 0.902 0.748 1.07 0.457 0.248 0.0654 1.185 1.58 0.981 2.59 -0.007 0.281 0.98 0.009 0.993 0.576 1.72 -0.131 0.268 0.623 0.205 0.877 0.522 1.48 PRS_PLINK_1.99526231496888e.08 FALSE 702.4 Degenerative skin disorders Both 8 29 13 dermatologic firebrick 29, 8 3, 0 7, 3 7, 2 7, 2 0.452 0.557 0.418 0.379 1.57 0.548 5.19 0.164 4.04 0.968 0.014 1.18 5.52e-05 9010 2.96 10.4 0.776 0.11 19.3 1.35e-11 2.22e+11 1.03 2.81 0.715 0.146 2.79 0.00128 1930 PRS_PLINK_1.99526231496888e.08 TRUE 703 Diseases of nail, NOS Both 102 336 13 dermatologic firebrick 336, 102 49, 10 112, 35 57, 20 83, 26 -0.0143 0.141 0.919 0.037 0.986 0.738 1.28 0.288 0.414 0.487 0.313 1.33 0.612 3.08 0.493 0.448 0.271 0.567 1.64 0.698 4.04 0.281 0.442 0.525 0.28 1.32 0.566 3.25 PRS_PLINK_1.99526231496888e.08 FALSE 703.1 Ingrowing nail Both 63 220 13 dermatologic firebrick 220, 63 31, 7 77, 20 32, 6 55, 23 0.05 0.162 0.757 0.121 1.05 0.745 1.4 0.0314 0.513 0.951 0.022 1.03 0.394 2.9 -0.243 0.618 0.694 0.159 0.784 0.227 2.62 0.517 0.507 0.308 0.512 1.68 0.65 4.7 PRS_PLINK_1.99526231496888e.08 FALSE 704 Diseases of hair and hair follicles Both 248 758 13 dermatologic firebrick 758, 248 117, 47 232, 85 147, 41 186, 45 -0.044 0.0749 0.557 0.254 0.957 0.818 1.1 -0.0662 0.219 0.763 0.118 0.936 0.613 1.44 -0.341 0.253 0.177 0.753 0.711 0.434 1.16 -0.51 0.245 0.0377 1.423 0.6 0.371 0.968 PRS_PLINK_1.99526231496888e.08 FALSE 704.1 Alopecia Both 143 459 13 dermatologic firebrick 459, 143 75, 23 139, 54 86, 22 115, 26 0.0322 0.0891 0.717 0.144 1.03 0.857 1.21 0.132 0.299 0.658 0.182 1.14 0.645 2.06 -0.113 0.345 0.742 0.129 0.893 0.457 1.75 -0.271 0.33 0.411 0.386 0.762 0.4 1.46 PRS_PLINK_1.99526231496888e.08 FALSE 704.11 Alopecia Areata Both 4 27 13 dermatologic firebrick 27, 4 3, 0 7, 4 6, 0 7, 0 -0.273 0.764 0.72 0.142 0.761 0.156 4.23 0.538 3.16 0.865 0.063 1.71 9.49e-06 19700 PRS_PLINK_1.99526231496888e.08 TRUE 704.12 Telogen effluvium Both 5 24 13 dermatologic firebrick 24, 5 6, 1 6, 2 5, 0 6, 1 -1.45 0.939 0.124 0.908 0.236 0.0158 1.12 -0.0717 1.64 0.965 0.015 0.931 0.0421 12.3 -1.37 1.82 0.454 0.343 0.255 0.00164 4.86 -2.91 3.75 0.438 0.359 0.0545 0.0182 10.4 PRS_PLINK_1.99526231496888e.08 TRUE 704.2 Hirsutism Both 55 144 13 dermatologic firebrick 144, 55 23, 9 47, 18 25, 5 36, 18 -0.049 0.158 0.757 0.121 0.952 0.663 1.24 0.0112 0.5 0.982 0.008 1.01 0.401 2.66 -1 0.706 0.155 0.809 0.367 0.0766 1.32 0.2 0.531 0.707 0.151 1.22 0.454 3.46 PRS_PLINK_1.99526231496888e.08 FALSE 704.8 Other specified diseases of hair and hair follicles Both 115 430 13 dermatologic firebrick 430, 115 71, 23 131, 35 83, 18 108, 24 -0.185 0.127 0.147 0.831 0.831 0.637 1.05 -0.136 0.317 0.668 0.175 0.873 0.474 1.63 -0.379 0.371 0.307 0.513 0.685 0.328 1.41 -0.533 0.353 0.131 0.884 0.587 0.292 1.16 PRS_PLINK_1.99526231496888e.08 FALSE 705 Disorders of sweat glands Both 49 214 13 dermatologic firebrick 214, 49 28, 8 71, 15 33, 9 54, 13 -0.0579 0.143 0.686 0.164 0.944 0.658 1.19 -0.418 0.53 0.431 0.366 0.658 0.239 1.87 0.0893 0.637 0.889 0.051 1.09 0.319 3.87 -0.313 0.545 0.567 0.247 0.732 0.253 2.14 PRS_PLINK_1.99526231496888e.08 TRUE 705.1 Dyshidrosis Both 13 38 13 dermatologic firebrick 38, 13 8, 1 11, 4 7, 3 10, 4 0.336 0.517 0.516 0.288 1.4 0.544 4.21 0.201 1.99 0.919 0.036 1.22 0.0043 2330 3.13 2.39 0.19 0.722 22.9 0.519 34200 0.89 1.33 0.503 0.298 2.44 0.267 44.6 PRS_PLINK_1.99526231496888e.08 TRUE 705.3 Hidradenitis Both 17 107 13 dermatologic firebrick 107, 17 11, 3 38, 5 15, 2 27, 6 -5.52e-05 0.216 1 0 1 0.594 1.43 -0.325 0.777 0.675 0.17 0.722 0.175 3.42 0.102 1.06 0.923 0.035 1.11 0.132 9.11 -0.537 0.926 0.562 0.25 0.585 0.0834 3.49 PRS_PLINK_1.99526231496888e.08 TRUE 705.8 Hyperhidrosis Both 83 273 13 dermatologic firebrick 273, 83 40, 15 93, 29 44, 8 67, 22 -0.00238 0.11 0.983 0.008 0.998 0.783 1.21 -0.274 0.385 0.477 0.321 0.76 0.364 1.62 -0.689 0.479 0.15 0.823 0.502 0.192 1.24 -0.226 0.407 0.579 0.237 0.798 0.365 1.76 PRS_PLINK_1.99526231496888e.08 FALSE 706 Diseases of sebaceous glands Both 405 799 13 dermatologic firebrick 799, 405 110, 63 266, 132 133, 67 196, 110 0.0786 0.0617 0.202 0.694 1.08 0.961 1.22 -0.114 0.196 0.562 0.25 0.892 0.61 1.31 -0.112 0.223 0.615 0.211 0.894 0.581 1.38 -0.0438 0.202 0.828 0.082 0.957 0.648 1.42 PRS_PLINK_1.99526231496888e.08 FALSE 706.1 Acne Both 243 637 13 dermatologic firebrick 637, 243 83, 35 214, 80 105, 41 158, 69 0.119 0.0726 0.101 0.996 1.13 0.98 1.3 -0.0952 0.246 0.698 0.156 0.909 0.566 1.48 -0.0637 0.279 0.82 0.086 0.938 0.547 1.62 0.0582 0.254 0.819 0.087 1.06 0.651 1.74 PRS_PLINK_1.99526231496888e.08 FALSE 706.2 Sebaceous cyst Both 154 545 13 dermatologic firebrick 545, 154 76, 22 184, 53 91, 22 133, 48 0.18 0.102 0.0765 1.116 1.2 0.983 1.46 -0.0466 0.291 0.873 0.059 0.954 0.546 1.71 -0.144 0.347 0.678 0.169 0.866 0.439 1.7 0.195 0.296 0.511 0.292 1.22 0.689 2.19 PRS_PLINK_1.99526231496888e.08 FALSE 706.3 Seborrhea Both 8 13 13 dermatologic firebrick 13, 8 3, 2 3, 2 3, 3 3, 1 -0.0858 0.848 0.919 0.037 0.918 0.174 3.81 1.63 42.5 0.97 0.013 5.08 0.0112 1250 -0.165 2.71 0.951 0.022 0.848 0.00556 148 -0.128 2.09 0.951 0.022 0.88 0.0178 1.03 PRS_PLINK_1.99526231496888e.08 TRUE 706.8 Other specified diseases of sebaceous glands Both 92 275 13 dermatologic firebrick 275, 92 47, 17 78, 28 59, 14 68, 24 -0.132 0.155 0.394 0.404 0.876 0.637 1.17 0.0376 0.38 0.921 0.036 1.04 0.504 2.18 -0.283 0.435 0.515 0.288 0.753 0.323 1.74 -0.28 0.391 0.474 0.324 0.756 0.354 1.61 PRS_PLINK_1.99526231496888e.08 FALSE 707 Chronic ulcer of skin Both 87 599 13 dermatologic firebrick 599, 87 91, 14 220, 26 77, 13 149, 27 0.136 0.105 0.194 0.712 1.15 0.924 1.39 -0.384 0.357 0.282 0.55 0.681 0.34 1.4 0.00654 0.409 0.987 0.006 1.01 0.444 2.26 0.149 0.356 0.675 0.171 1.16 0.584 2.39 PRS_PLINK_1.99526231496888e.08 FALSE 707.1 Decubitus ulcer Both 22 153 13 dermatologic firebrick 153, 22 24, 4 54, 8 22, 3 37, 5 -0.055 0.234 0.814 0.089 0.947 0.466 1.34 -0.649 0.679 0.339 0.469 0.523 0.137 2.05 -0.53 0.87 0.542 0.266 0.588 0.0849 3.32 -0.0906 0.704 0.898 0.047 0.913 0.23 3.7 PRS_PLINK_1.99526231496888e.08 TRUE 707.2 Chronic ulcer of leg or foot Both 35 189 13 dermatologic firebrick 189, 35 35, 6 47, 11 46, 7 47, 8 0.0899 0.191 0.637 0.196 1.09 0.664 1.48 -0.0158 0.575 0.978 0.01 0.984 0.317 3.15 -0.0946 0.58 0.87 0.06 0.91 0.29 2.91 -0.00342 0.591 0.995 0.002 0.997 0.311 3.28 PRS_PLINK_1.99526231496888e.08 TRUE 707.3 Chronic ulcer of unspecified site Both 58 404 13 dermatologic firebrick 404, 58 53, 8 104, 12 100, 12 98, 21 0.26 0.131 0.0467 1.33 1.3 1.02 1.69 -0.313 0.489 0.522 0.283 0.731 0.28 1.98 -0.222 0.487 0.649 0.188 0.801 0.309 2.17 0.315 0.439 0.474 0.324 1.37 0.595 3.4 PRS_PLINK_1.99526231496888e.08 FALSE 709 Diffuse diseases of connective tissue Both 81 344 13 dermatologic firebrick 344, 81 48, 6 118, 33 55, 10 85, 23 0.203 0.127 0.109 0.964 1.23 0.964 1.58 0.662 0.473 0.162 0.791 1.94 0.806 5.33 0.196 0.556 0.724 0.14 1.22 0.403 3.85 0.777 0.479 0.104 0.981 2.18 0.883 6.06 PRS_PLINK_1.99526231496888e.08 FALSE 709.2 Sicca syndrome Both 27 109 13 dermatologic firebrick 109, 27 16, 4 37, 7 16, 3 27, 8 -0.0352 0.264 0.894 0.049 0.965 0.565 1.6 -0.16 0.716 0.823 0.084 0.852 0.224 3.57 -0.0744 0.926 0.936 0.029 0.928 0.145 5.84 0.423 0.774 0.585 0.233 1.53 0.361 8.33 PRS_PLINK_1.99526231496888e.08 TRUE 709.3 Systemic sclerosis Both 12 51 13 dermatologic firebrick 51, 12 5, 1 14, 5 11, 1 13, 4 0.286 0.221 0.196 0.708 1.33 0.946 2.26 0.121 1.23 0.922 0.035 1.13 0.139 13.5 -1.07 1.4 0.443 0.353 0.342 0.00699 3.79 0.906 1.34 0.498 0.303 2.47 0.266 48.7 PRS_PLINK_1.99526231496888e.08 TRUE 709.5 Dermatomyositis Both 4 21 13 dermatologic firebrick 21, 4 2, 1 5, 0 5, 0 5, 3 -0.177 0.969 0.855 0.068 0.838 0.0477 7.07 -0.963 271 0.997 0.001 0.382 0.315 0.256 0.321 23.4 0.989 0.005 1.38 0.0818 91.6 -0.0658 2.89 0.982 0.008 0.936 0.0111 125 PRS_PLINK_1.99526231496888e.08 TRUE 709.6 Other specified diffuse diseases of connective tissue Both 5 22 13 dermatologic firebrick 22, 5 2, 0 5, 0 5, 3 6, 2 0.505 0.704 0.473 0.325 1.66 0.458 12.1 -1.64 7.97 0.837 0.077 0.193 0.171 0.223 0.761 4.05 0.851 0.07 2.14 0.0126 754 PRS_PLINK_1.99526231496888e.08 TRUE 709.7 Unspecified diffuse connective tissue disease Both 59 242 13 dermatologic firebrick 242, 59 37, 5 80, 24 38, 6 59, 18 0.111 0.189 0.557 0.254 1.12 0.77 1.62 0.673 0.536 0.209 0.679 1.96 0.719 6.19 -0.151 0.66 0.819 0.087 0.86 0.229 3.21 0.721 0.54 0.182 0.741 2.06 0.741 6.54 PRS_PLINK_1.99526231496888e.08 FALSE 710 Osteomyelitis, periostitis, and other infections involving bone Both 34 212 14 musculoskeletal darkolivegreen 212, 34 21, 3 76, 16 31, 1 52, 10 0.102 0.174 0.56 0.252 1.11 0.796 1.56 0.39 0.692 0.573 0.242 1.48 0.42 6.58 -1.19 0.901 0.186 0.73 0.304 0.0302 1.91 -0.0767 0.684 0.911 0.041 0.926 0.247 3.96 PRS_PLINK_1.99526231496888e.08 TRUE 710.1 Osteomyelitis Both 32 204 14 musculoskeletal darkolivegreen 204, 32 19, 3 51, 10 51, 5 51, 10 0.143 0.185 0.439 0.357 1.15 0.829 1.7 0.0393 0.731 0.957 0.019 1.04 0.264 4.92 -1.03 0.794 0.196 0.707 0.358 0.0705 1.74 -0.119 0.694 0.864 0.064 0.888 0.235 3.84 PRS_PLINK_1.99526231496888e.08 TRUE 710.11 Acute osteomyelitis Both 15 97 14 musculoskeletal darkolivegreen 97, 15 13, 2 34, 6 14, 1 24, 4 -0.419 0.407 0.303 0.518 0.658 0.265 1.47 -0.865 1.16 0.458 0.34 0.421 0.0159 4.61 -0.476 1.1 0.665 0.177 0.621 0.0578 5.01 -0.225 0.881 0.799 0.098 0.799 0.144 4.96 PRS_PLINK_1.99526231496888e.08 TRUE 710.12 Chronic osteomyelitis Both 16 79 14 musculoskeletal darkolivegreen 79, 16 12, 1 19, 1 18, 6 20, 5 0.0998 0.226 0.658 0.182 1.1 0.756 1.8 -1.46 1.44 0.313 0.504 0.233 0.00126 5.63 0.84 1.03 0.414 0.383 2.32 0.351 30 -1.26 1.32 0.339 0.47 0.284 0.014 3.88 PRS_PLINK_1.99526231496888e.08 TRUE 710.19 Unspecified osteomyelitis Both 29 202 14 musculoskeletal darkolivegreen 202, 29 20, 3 50, 9 50, 4 51, 9 0.132 0.186 0.479 0.32 1.14 0.811 1.66 0.0658 0.764 0.931 0.031 1.07 0.251 5.46 -1.08 0.816 0.187 0.727 0.341 0.047 1.86 -0.124 0.708 0.861 0.065 0.884 0.226 3.94 PRS_PLINK_1.99526231496888e.08 TRUE 711 Arthropathy associated with infections Both 16 56 14 musculoskeletal darkolivegreen 56, 16 6, 1 17, 5 11, 2 14, 8 1.11 0.491 0.0239 1.622 3.03 1.25 8.95 -1.39 1.68 0.409 0.389 0.249 0.00771 7.04 1.17 2.01 0.56 0.251 3.23 0.128 1470 1.85 1.59 0.245 0.612 6.36 0.532 4670 PRS_PLINK_1.99526231496888e.08 TRUE 711.1 Pyogenic arthritis Both 10 33 14 musculoskeletal darkolivegreen 33, 10 4, 1 10, 4 6, 1 8, 4 0.874 0.638 0.171 0.768 2.4 0.775 10.3 -3.58 3.44 0.298 0.526 0.0278 0.0194 5.05 0.228 2.55 0.929 0.032 1.26 0.000453 97.8 2.03 2.09 0.332 0.478 7.59 0.259 1240 PRS_PLINK_1.99526231496888e.08 TRUE 712 Infective connective tissue disorders Both 8 35 14 musculoskeletal darkolivegreen 35, 8 4, 1 10, 3 7, 1 9, 2 -0.205 0.582 0.725 0.14 0.815 0.267 2.37 -0.195 2.15 0.928 0.033 0.823 0.000594 457 0.555 2.7 0.837 0.077 1.74 0.00814 2950 -0.221 1.5 0.883 0.054 0.802 0.0376 14.5 PRS_PLINK_1.99526231496888e.08 TRUE 713 Arthropathy associated with other disorders classified elsewhere Both 19 79 14 musculoskeletal darkolivegreen 79, 19 15, 0 25, 6 14, 4 20, 8 0.387 0.368 0.292 0.534 1.47 0.738 3.06 2.55 1.74 0.144 0.842 12.8 0.633 999 1.79 1.34 0.181 0.742 5.99 0.6 1010 3.13 1.61 0.0515 1.288 22.9 1.61 56000 PRS_PLINK_1.99526231496888e.08 TRUE 713.5 Arthropathy associated with neurological disorders Both 9 37 14 musculoskeletal darkolivegreen 37, 9 9, 0 8, 4 9, 2 9, 3 0.368 0.53 0.488 0.312 1.44 0.558 4.17 4.27 2.85 0.133 0.876 71.7 0.865 1.89e+10 -0.0754 1.95 0.969 0.014 0.927 0.00142 205 2.07 1.99 0.298 0.526 7.96 0.196 190000 PRS_PLINK_1.99526231496888e.08 TRUE 714 Rheumatoid arthritis and other inflammatory polyarthropathies Both 75 456 14 musculoskeletal darkolivegreen 456, 75 72, 8 152, 29 73, 14 114, 20 0.114 0.167 0.494 0.307 1.12 0.807 1.56 0.266 0.421 0.527 0.278 1.3 0.586 3.16 0.38 0.472 0.421 0.376 1.46 0.581 3.86 0.297 0.442 0.502 0.299 1.35 0.57 3.4 PRS_PLINK_1.99526231496888e.08 FALSE 714.1 Rheumatoid arthritis Both 54 359 14 musculoskeletal darkolivegreen 359, 54 49, 4 128, 21 52, 14 88, 14 0.392 0.209 0.0605 1.218 1.48 0.985 2.26 0.313 0.546 0.566 0.247 1.37 0.491 4.59 0.875 0.585 0.135 0.869 2.4 0.785 8.61 0.439 0.56 0.433 0.363 1.55 0.523 5.35 PRS_PLINK_1.99526231496888e.08 FALSE 714.2 Juvenile rheumatoid arthritis Both 4 31 14 musculoskeletal darkolivegreen 31, 4 5, 0 9, 2 6, 2 8, 0 -0.247 0.533 0.644 0.191 0.781 0.198 1.9 1.08 2.07 0.604 0.219 2.93 0.0734 1.26e+08 1.38 2.22 0.535 0.272 3.97 0.155 425000 PRS_PLINK_1.99526231496888e.08 TRUE 715 Other inflammatory spondylopathies Both 59 214 14 musculoskeletal darkolivegreen 214, 59 24, 4 59, 15 47, 19 54, 15 0.183 0.207 0.378 0.422 1.2 0.805 1.8 0.124 0.668 0.852 0.069 1.13 0.329 4.49 0.637 0.619 0.304 0.518 1.89 0.618 6.99 0.39 0.68 0.566 0.247 1.48 0.42 5.94 PRS_PLINK_1.99526231496888e.08 FALSE 715.1 Sacroiliitis NEC Both 12 52 14 musculoskeletal darkolivegreen 52, 12 6, 3 14, 1 12, 4 13, 4 0.434 0.46 0.346 0.462 1.54 0.653 4.04 -0.923 1.23 0.455 0.342 0.397 0.0345 3.03 -0.839 1.51 0.579 0.237 0.432 0.0191 5.5 -1.98 1.51 0.19 0.722 0.138 0.000978 1.71 PRS_PLINK_1.99526231496888e.08 TRUE 715.2 Ankylosing spondylitis Both 11 42 14 musculoskeletal darkolivegreen 42, 11 6, 0 10, 5 10, 4 11, 1 -0.0491 0.482 0.919 0.037 0.952 0.379 2.54 2.42 1.92 0.207 0.684 11.3 0.698 1950 1.47 1.55 0.342 0.466 4.36 0.346 2510 1.16 1.92 0.545 0.264 3.2 0.16 165000 PRS_PLINK_1.99526231496888e.08 TRUE 716 Other arthropathies Both 400 826 14 musculoskeletal darkolivegreen 826, 400 123, 48 278, 138 134, 61 205, 109 0.0624 0.0664 0.347 0.46 1.06 0.933 1.21 0.0672 0.217 0.757 0.121 1.07 0.703 1.64 0.154 0.25 0.54 0.268 1.17 0.717 1.9 0.236 0.228 0.302 0.521 1.27 0.814 1.98 PRS_PLINK_1.99526231496888e.08 FALSE 716.1 Unspecified polyarthropathy or polyarthritis Both 9 67 14 musculoskeletal darkolivegreen 67, 9 10, 0 16, 1 16, 2 17, 6 0.848 0.485 0.0802 1.096 2.34 1.02 9.09 0.388 1.41 0.782 0.107 1.47 0.0624 195 1.15 1.47 0.435 0.362 3.16 0.212 7.28e+11 2.08 1.63 0.202 0.695 8.03 0.548 3720 PRS_PLINK_1.99526231496888e.08 TRUE 716.2 Unspecified monoarthritis Both 7 23 14 musculoskeletal darkolivegreen 23, 7 8, 3 3, 1 4, 1 6, 2 -0.168 0.934 0.857 0.067 0.846 0.08 6.77 1.13 2.52 0.654 0.184 3.1 0.0497 59000 0.807 1.96 0.681 0.167 2.24 0.0569 4880 -0.791 1.47 0.591 0.228 0.453 0.00623 7.48 PRS_PLINK_1.99526231496888e.08 TRUE 716.9 Arthropathy NOS Both 399 826 14 musculoskeletal darkolivegreen 826, 399 123, 48 278, 138 134, 61 205, 108 0.0515 0.0685 0.452 0.345 1.05 0.918 1.2 0.0672 0.217 0.757 0.121 1.07 0.703 1.64 0.154 0.25 0.54 0.268 1.17 0.717 1.9 0.228 0.229 0.318 0.498 1.26 0.808 1.97 PRS_PLINK_1.99526231496888e.08 FALSE 717 Polymyalgia Rheumatica Both 5 37 14 musculoskeletal darkolivegreen 37, 5 8, 0 9, 2 9, 2 9, 1 0.132 0.653 0.839 0.076 1.14 0.348 5.13 1.04 1.84 0.572 0.243 2.83 0.0517 419 1.68 1.77 0.343 0.465 5.38 0.27 84500 0.0227 1.45 0.988 0.005 1.02 0.0118 62.8 PRS_PLINK_1.99526231496888e.08 TRUE 720 Spinal stenosis Both 84 500 14 musculoskeletal darkolivegreen 500, 84 71, 6 124, 23 123, 21 125, 29 0.26 0.119 0.0294 1.532 1.3 1.04 1.65 0.56 0.478 0.241 0.617 1.75 0.71 4.85 0.41 0.485 0.398 0.4 1.51 0.594 4.27 0.839 0.459 0.0677 1.169 2.31 0.976 6.23 PRS_PLINK_1.99526231496888e.08 FALSE 720.1 Spinal stenosis of lumbar region Both 55 332 14 musculoskeletal darkolivegreen 332, 55 43, 4 84, 16 81, 16 83, 17 0.129 0.167 0.44 0.356 1.14 0.812 1.56 0.388 0.575 0.5 0.301 1.47 0.502 5.12 0.454 0.593 0.444 0.352 1.57 0.517 5.64 0.447 0.561 0.426 0.37 1.56 0.543 5.33 PRS_PLINK_1.99526231496888e.08 FALSE 721 Spondylosis and allied disorders Both 229 715 14 musculoskeletal darkolivegreen 715, 229 105, 25 237, 86 122, 38 176, 61 0.131 0.0767 0.0876 1.058 1.14 0.979 1.32 0.341 0.273 0.211 0.675 1.41 0.835 2.43 0.379 0.311 0.223 0.651 1.46 0.802 2.71 0.389 0.286 0.174 0.758 1.48 0.852 2.61 PRS_PLINK_1.99526231496888e.08 FALSE 721.1 Spondylosis without myelopathy Both 220 693 14 musculoskeletal darkolivegreen 693, 220 103, 23 230, 84 118, 37 171, 57 0.133 0.0819 0.104 0.983 1.14 0.973 1.34 0.394 0.281 0.161 0.793 1.48 0.868 2.6 0.434 0.321 0.176 0.754 1.54 0.832 2.92 0.394 0.294 0.181 0.743 1.48 0.843 2.67 PRS_PLINK_1.99526231496888e.08 FALSE 721.2 Spondylosis with myelopathy Both 17 126 14 musculoskeletal darkolivegreen 126, 17 20, 1 39, 6 22, 3 32, 6 0.124 0.221 0.574 0.241 1.13 0.663 1.65 0.594 0.902 0.511 0.292 1.81 0.329 17.7 1.65 1.28 0.197 0.706 5.22 0.274 4530 0.498 1.07 0.64 0.194 1.65 0.186 21.7 PRS_PLINK_1.99526231496888e.08 TRUE 721.8 Other allied disorders of spine Both 14 49 14 musculoskeletal darkolivegreen 49, 14 9, 3 12, 3 12, 5 12, 2 -0.457 0.479 0.34 0.469 0.633 0.255 1.54 -0.315 1.16 0.785 0.105 0.729 0.0843 6.01 0.925 1.22 0.45 0.347 2.52 0.269 27.4 -0.433 1.89 0.818 0.087 0.648 0.00456 125 PRS_PLINK_1.99526231496888e.08 TRUE 722 Intervertebral disc disorders Both 231 793 14 musculoskeletal darkolivegreen 793, 231 122, 25 263, 93 135, 30 195, 60 0.0543 0.0798 0.496 0.304 1.06 0.897 1.23 0.517 0.265 0.0506 1.296 1.68 1.01 2.85 0.0818 0.324 0.801 0.097 1.09 0.576 2.06 0.419 0.283 0.139 0.856 1.52 0.883 2.68 PRS_PLINK_1.99526231496888e.08 FALSE 722.1 Displacement of intervertebral disc Both 142 677 14 musculoskeletal darkolivegreen 677, 142 100, 14 224, 51 116, 20 166, 39 0.0913 0.0889 0.304 0.516 1.1 0.915 1.29 0.414 0.327 0.206 0.687 1.51 0.813 2.96 0.326 0.401 0.417 0.38 1.38 0.635 3.12 0.539 0.354 0.128 0.892 1.71 0.872 3.53 PRS_PLINK_1.99526231496888e.08 FALSE 722.3 Schmorl's nodes Both 10 17 14 musculoskeletal darkolivegreen 17, 10 5, 1 5, 5 3, 3 4, 1 0.109 0.786 0.89 0.051 1.11 0.257 4.66 1.12 1.54 0.468 0.329 3.06 0.274 60 -0.603 2.11 0.774 0.111 0.547 0.0807 12.1 1.35 7.17 0.85 0.07 3.87 1.27e-05 4450000 PRS_PLINK_1.99526231496888e.08 TRUE 722.6 Degeneration of intervertebral disc Both 147 620 14 musculoskeletal darkolivegreen 620, 147 93, 16 211, 63 104, 21 150, 36 0.0803 0.0977 0.411 0.386 1.08 0.887 1.3 0.435 0.322 0.177 0.751 1.54 0.837 2.97 0.0752 0.39 0.847 0.072 1.08 0.503 2.33 0.199 0.342 0.561 0.251 1.22 0.631 2.43 PRS_PLINK_1.99526231496888e.08 FALSE 722.7 Intervertebral disc disorder with myelopathy Both 12 90 14 musculoskeletal darkolivegreen 90, 12 14, 1 22, 6 21, 1 23, 4 0.213 0.245 0.384 0.415 1.24 0.549 1.88 0.497 1.18 0.673 0.172 1.64 0.18 30.4 -0.122 1.19 0.918 0.037 0.885 0.0496 79.4 2.41 1.66 0.147 0.834 11.1 0.615 137000 PRS_PLINK_1.99526231496888e.08 TRUE 722.8 Postlaminectomy syndrome Both 12 76 14 musculoskeletal darkolivegreen 76, 12 13, 2 23, 1 15, 4 19, 5 0.183 0.267 0.492 0.308 1.2 0.693 1.92 -0.878 1.13 0.437 0.36 0.415 0.0163 4.98 0.779 1 0.436 0.36 2.18 0.366 17.8 1.53 1.22 0.208 0.683 4.63 0.534 83.6 PRS_PLINK_1.99526231496888e.08 TRUE 722.9 Other and unspecified disc disorder Both 89 414 14 musculoskeletal darkolivegreen 414, 89 66, 8 140, 41 63, 13 104, 19 0.0506 0.118 0.667 0.176 1.05 0.824 1.3 0.792 0.408 0.0523 1.282 2.21 1.03 5.23 0.528 0.514 0.305 0.516 1.7 0.624 4.87 0.331 0.459 0.471 0.327 1.39 0.573 3.63 PRS_PLINK_1.99526231496888e.08 FALSE 723 Other disorders of cervical region Both 55 242 14 musculoskeletal darkolivegreen 242, 55 29, 4 81, 20 39, 8 61, 16 0.152 0.126 0.229 0.64 1.16 0.918 1.49 0.252 0.577 0.663 0.179 1.29 0.44 4.46 0.294 0.654 0.653 0.185 1.34 0.376 5.6 0.438 0.632 0.488 0.311 1.55 0.482 5.86 PRS_PLINK_1.99526231496888e.08 FALSE 723.1 Torticollis Both 8 64 14 musculoskeletal darkolivegreen 64, 8 6, 0 24, 2 8, 1 16, 3 0.176 0.433 0.684 0.165 1.19 0.462 3.03 -1.26 2.05 0.54 0.268 0.285 2.16e-05 44.5 1.22 2.04 0.549 0.26 3.4 0.108 1970 -0.992 2.53 0.694 0.158 0.371 1.94e-05 210 PRS_PLINK_1.99526231496888e.08 TRUE 724 Other and unspecified disorders of back Both 222 779 14 musculoskeletal darkolivegreen 779, 222 116, 24 257, 79 133, 32 193, 67 0.147 0.0715 0.0398 1.4 1.16 1.01 1.33 0.356 0.266 0.181 0.742 1.43 0.858 2.44 0.161 0.306 0.599 0.223 1.17 0.648 2.15 0.5 0.275 0.0694 1.159 1.65 0.972 2.87 PRS_PLINK_1.99526231496888e.08 FALSE 724.1 Disorders of sacrum Both 151 573 14 musculoskeletal darkolivegreen 573, 151 93, 18 195, 54 83, 20 143, 46 0.198 0.0828 0.017 1.77 1.22 1.04 1.44 0.348 0.307 0.258 0.589 1.42 0.787 2.64 0.26 0.37 0.482 0.317 1.3 0.63 2.69 0.492 0.314 0.117 0.933 1.64 0.897 3.08 PRS_PLINK_1.99526231496888e.08 FALSE 724.2 Disorders of coccyx Both 34 138 14 musculoskeletal darkolivegreen 138, 34 21, 6 37, 9 31, 10 35, 4 -0.508 0.274 0.0642 1.193 0.602 0.339 1.01 -0.0277 0.689 0.968 0.014 0.973 0.266 3.91 0.0827 0.642 0.897 0.047 1.09 0.324 3.81 -0.905 0.724 0.211 0.675 0.405 0.0855 1.61 PRS_PLINK_1.99526231496888e.08 TRUE 724.8 Other symptoms referable to back Both 52 226 14 musculoskeletal darkolivegreen 226, 52 33, 5 75, 20 38, 10 56, 16 0.449 0.221 0.0423 1.373 1.57 1.03 2.44 0.44 0.537 0.413 0.384 1.55 0.577 4.76 0.438 0.618 0.478 0.32 1.55 0.483 5.48 0.549 0.562 0.329 0.483 1.73 0.601 5.71 PRS_PLINK_1.99526231496888e.08 FALSE 724.9 Other unspecified back disorders Both 47 266 14 musculoskeletal darkolivegreen 266, 47 35, 4 68, 12 64, 11 67, 16 0.212 0.12 0.0778 1.109 1.24 0.979 1.54 0.201 0.589 0.732 0.135 1.22 0.399 4.28 0.297 0.578 0.607 0.217 1.35 0.452 4.64 0.412 0.58 0.478 0.321 1.51 0.502 5.27 PRS_PLINK_1.99526231496888e.08 TRUE 726 Peripheral enthesopathies and allied syndromes Both 493 519 14 musculoskeletal darkolivegreen 519, 493 82, 54 165, 174 93, 63 130, 139 -0.00455 0.0669 0.946 0.024 0.995 0.871 1.13 0.367 0.234 0.117 0.933 1.44 0.918 2.28 0.0193 0.267 0.942 0.026 1.02 0.608 1.71 0.401 0.234 0.087 1.06 1.49 0.95 2.36 PRS_PLINK_1.99526231496888e.08 FALSE 726.1 Enthesopathy Both 388 518 14 musculoskeletal darkolivegreen 518, 388 82, 38 165, 138 93, 46 129, 115 -0.00442 0.0719 0.951 0.022 0.996 0.861 1.14 0.508 0.258 0.0489 1.311 1.66 1.01 2.76 0.0765 0.298 0.797 0.098 1.08 0.607 1.93 0.556 0.258 0.0311 1.507 1.74 1.06 2.9 PRS_PLINK_1.99526231496888e.08 FALSE 726.2 Synoviopathy Both 59 123 14 musculoskeletal darkolivegreen 123, 59 20, 5 45, 28 16, 4 31, 15 0.113 0.185 0.54 0.267 1.12 0.797 1.62 0.821 0.593 0.166 0.78 2.27 0.782 7.61 0.284 0.882 0.747 0.127 1.33 0.24 7.11 0.531 0.622 0.393 0.405 1.7 0.546 5.87 PRS_PLINK_1.99526231496888e.08 FALSE 726.3 Bursitis Both 114 248 14 musculoskeletal darkolivegreen 248, 114 40, 14 83, 34 41, 13 62, 40 -0.0116 0.135 0.932 0.031 0.988 0.751 1.27 0.0873 0.413 0.833 0.08 1.09 0.495 2.48 -0.296 0.483 0.539 0.268 0.744 0.285 1.86 0.409 0.396 0.302 0.521 1.51 0.71 3.28 PRS_PLINK_1.99526231496888e.08 FALSE 726.4 Calcaneal spur; Exostosis NOS Both 59 190 14 musculoskeletal darkolivegreen 190, 59 31, 6 47, 14 46, 8 48, 27 0.496 0.211 0.0188 1.726 1.64 1.1 2.51 0.638 0.632 0.312 0.505 1.89 0.582 7.17 -0.153 0.603 0.799 0.097 0.858 0.261 2.9 1.03 0.543 0.0587 1.232 2.79 1.03 8.49 PRS_PLINK_1.99526231496888e.08 FALSE 727 Other disorders of synovium, tendon, and bursa Both 362 517 14 musculoskeletal darkolivegreen 517, 362 82, 33 165, 143 92, 58 129, 88 0.00929 0.0721 0.897 0.047 1.01 0.874 1.16 0.717 0.259 0.00562 2.25 2.05 1.25 3.42 0.39 0.292 0.183 0.739 1.48 0.841 2.62 0.444 0.274 0.105 0.978 1.56 0.921 2.67 PRS_PLINK_1.99526231496888e.08 FALSE 727.1 Synovitis and tenosynovitis Both 176 457 14 musculoskeletal darkolivegreen 457, 176 75, 14 146, 69 82, 27 111, 47 0.0827 0.0832 0.32 0.494 1.09 0.922 1.27 0.912 0.341 0.00743 2.129 2.49 1.31 5 0.494 0.381 0.194 0.712 1.64 0.791 3.51 0.684 0.36 0.0576 1.24 1.98 1 4.11 PRS_PLINK_1.99526231496888e.08 FALSE 727.2 Bursitis disorders Both 21 55 14 musculoskeletal darkolivegreen 55, 21 10, 1 16, 4 12, 4 13, 11 0.845 0.521 0.105 0.979 2.33 0.919 6.91 0.882 1.55 0.569 0.245 2.42 0.0672 759000 1.53 1.76 0.384 0.415 4.63 0.283 770 1.16 1.05 0.27 0.569 3.18 0.549 31.2 PRS_PLINK_1.99526231496888e.08 TRUE 727.4 Ganglion and cyst of synovium, tendon, and bursa Both 93 219 14 musculoskeletal darkolivegreen 219, 93 36, 10 76, 35 32, 8 55, 30 0.116 0.149 0.434 0.363 1.12 0.848 1.51 0.414 0.439 0.345 0.462 1.51 0.668 3.64 -0.255 0.555 0.646 0.19 0.775 0.255 2.22 0.539 0.452 0.233 0.633 1.71 0.732 4.2 PRS_PLINK_1.99526231496888e.08 FALSE 727.5 Rupture of synovium Both 18 58 14 musculoskeletal darkolivegreen 58, 18 10, 0 16, 5 12, 3 15, 8 0.257 0.431 0.551 0.259 1.29 0.568 3.14 1.48 1.76 0.401 0.397 4.38 0.239 2600 0.826 1.51 0.584 0.234 2.28 0.145 309 1.83 1.52 0.227 0.643 6.24 0.452 1780 PRS_PLINK_1.99526231496888e.08 TRUE 727.6 Rupture of tendon, nontraumatic Both 98 220 14 musculoskeletal darkolivegreen 220, 98 38, 15 73, 39 37, 12 55, 21 -0.0489 0.151 0.747 0.127 0.952 0.702 1.27 0.369 0.404 0.362 0.442 1.45 0.671 3.22 -0.0879 0.499 0.86 0.066 0.916 0.351 2.38 -0.146 0.441 0.741 0.13 0.865 0.367 2.04 PRS_PLINK_1.99526231496888e.08 FALSE 727.7 Contracture of tendon (sheath) Both 41 111 14 musculoskeletal darkolivegreen 111, 41 18, 4 32, 14 23, 8 28, 10 0.107 0.161 0.507 0.295 1.11 0.85 1.59 0.637 0.623 0.306 0.514 1.89 0.626 6.63 0.592 0.827 0.474 0.324 1.81 0.392 10.7 0.801 0.715 0.263 0.581 2.23 0.608 11.3 PRS_PLINK_1.99526231496888e.08 TRUE 727.8 Plica syndrome Both 7 29 14 musculoskeletal darkolivegreen 29, 7 4, 2 7, 3 7, 1 7, 0 -0.646 0.721 0.37 0.432 0.524 0.00557 2.47 -1.63 2.61 0.531 0.275 0.195 0.00044 73200 -0.463 2.39 0.846 0.072 0.629 0.00277 60.5 -0.352 1.6 0.826 0.083 0.703 0.0365 44.6 PRS_PLINK_1.99526231496888e.08 TRUE 728 Disorders of muscle, ligament, and fascia Both 198 507 14 musculoskeletal darkolivegreen 507, 198 80, 21 161, 73 93, 35 125, 49 0.0553 0.0751 0.462 0.336 1.06 0.909 1.22 0.546 0.296 0.0648 1.188 1.73 0.987 3.11 0.292 0.345 0.396 0.402 1.34 0.691 2.64 0.43 0.311 0.167 0.778 1.54 0.851 2.85 PRS_PLINK_1.99526231496888e.08 FALSE 728.1 Muscular calcification and ossification Both 8 9 14 musculoskeletal darkolivegreen 9, 8 3, 6 2, 1 3, 1 1, 0 -0.0496 0.261 0.849 0.071 0.952 0.503 1.57 -1.41 3.08 0.646 0.19 0.243 0.212 98.2 -3.31 6.82 0.627 0.202 0.0364 4.55e-08 1340 -4.31 12.3 0.727 0.138 0.0135 0.0101 0.0159 PRS_PLINK_1.99526231496888e.08 TRUE 728.2 Laxity of ligament or hypermobility syndrome Both 17 58 14 musculoskeletal darkolivegreen 58, 17 11, 2 19, 1 9, 3 15, 7 0.326 0.388 0.4 0.398 1.39 0.67 3.01 -1.43 1.28 0.264 0.578 0.24 0.00456 2.77 0.69 1.01 0.495 0.306 1.99 0.33 18.3 0.575 0.99 0.561 0.251 1.78 0.296 13.8 PRS_PLINK_1.99526231496888e.08 TRUE 728.7 Fasciitis Both 200 382 14 musculoskeletal darkolivegreen 382, 200 61, 28 116, 70 71, 23 96, 59 0.0257 0.0863 0.766 0.116 1.03 0.862 1.2 0.0994 0.296 0.737 0.133 1.1 0.626 1.97 -0.445 0.354 0.209 0.68 0.641 0.32 1.27 0.285 0.293 0.329 0.482 1.33 0.761 2.36 PRS_PLINK_1.99526231496888e.08 FALSE 728.71 Contracture of palmar fascia [Dupuytren's disease] Both 6 33 14 musculoskeletal darkolivegreen 33, 6 7, 0 13, 1 3, 1 8, 2 0.215 0.534 0.687 0.163 1.24 0.468 3.52 0.14 1.59 0.93 0.031 1.15 0.0295 200 1.22 3.18 0.701 0.154 3.39 0.0532 1540 0.614 1.61 0.702 0.153 1.85 0.0953 123 PRS_PLINK_1.99526231496888e.08 TRUE 729 Other disorders of soft tissues Both 196 445 14 musculoskeletal darkolivegreen 445, 196 74, 28 142, 68 81, 31 110, 50 -0.047 0.0995 0.637 0.196 0.954 0.772 1.14 0.327 0.288 0.257 0.591 1.39 0.8 2.45 0.0161 0.346 0.963 0.016 1.02 0.521 1.99 0.143 0.303 0.636 0.197 1.15 0.643 2.09 PRS_PLINK_1.99526231496888e.08 FALSE 729.1 Rheumatism, unspecified and fibrositis Both 5 14 14 musculoskeletal darkolivegreen 14, 5 4, 0 3, 1 3, 1 4, 2 0.0242 0.839 0.977 0.01 1.02 0.227 7.05 -0.231 9.8 0.981 0.008 0.794 0.767 0.824 -2.18 52.5 0.967 0.015 0.113 0.104 0.123 1.05 2.47 0.672 0.173 2.85 0.0844 32 PRS_PLINK_1.99526231496888e.08 TRUE 729.3 Panniculitis Both 4 14 14 musculoskeletal darkolivegreen 14, 4 4, 2 4, 0 2, 0 4, 1 -0.172 0.965 0.859 0.066 0.842 0.0903 5.32 -0.932 4.13 0.822 0.085 0.394 0.0736 3.26 0.164 18400000 1 0 1.18 4.11e-16 5.54e+12 0.862 3.52 0.806 0.093 2.37 0.000751 1870 PRS_PLINK_1.99526231496888e.08 TRUE 729.7 Nontraumatic compartment syndrome Both 5 7 14 musculoskeletal darkolivegreen 7, 5 0, 2 2, 2 1, 0 2, 0 -1.29 1.03 0.208 0.682 0.274 0.0166 1.11 -0.0329 4560 1 0 0.968 0.459 1.97 -0.00321 32.8 1 0 0.997 0.962 1.04 -0.0299 5850000 1 0 0.971 0.00787 318 PRS_PLINK_1.99526231496888e.08 TRUE 731 Osteitis deformans and osteopathies associated with other disorders classified elsewhere Both 4 33 14 musculoskeletal darkolivegreen 33, 4 5, 1 11, 1 5, 0 8, 1 0.00249 0.759 0.997 0.001 1 0.0127 83.8 -0.872 1.68 0.605 0.219 0.418 0.000284 25.6 0.595 4.28 0.889 0.051 1.81 1.46 2.12 -0.61 1.42 0.667 0.176 0.543 0.00428 8.65 PRS_PLINK_1.99526231496888e.08 TRUE 732 Osteochondropathies Both 12 91 14 musculoskeletal darkolivegreen 91, 12 12, 0 34, 5 11, 1 23, 5 0.606 0.449 0.177 0.752 1.83 0.763 5.17 0.0612 1.7 0.971 0.013 1.06 0.0139 220 -0.322 1.42 0.82 0.086 0.725 0.0103 95.8 1.12 1.29 0.384 0.415 3.07 0.314 552 PRS_PLINK_1.99526231496888e.08 TRUE 732.1 Juvenile osteochondrosis Both 11 40 14 musculoskeletal darkolivegreen 40, 11 6, 0 10, 4 11, 3 9, 3 0.017 0.439 0.969 0.014 1.02 0.367 2.17 -1.01 1.98 0.611 0.214 0.365 0.000354 67.4 9.24 6.58 0.16 0.795 10300 0.241 1.64e+12 0.917 2.36 0.697 0.157 2.5 0.0149 591 PRS_PLINK_1.99526231496888e.08 TRUE 732.7 Osteochondritis dissecans Both 0 34 14 musculoskeletal darkolivegreen 34, 0 4 13 3 9 PRS_PLINK_1.99526231496888e.08 TRUE 733 Other disorders of bone and cartilage Both 193 636 14 musculoskeletal darkolivegreen 636, 193 89, 19 219, 75 101, 29 157, 53 0.0922 0.0822 0.262 0.582 1.1 0.924 1.27 0.33 0.316 0.296 0.529 1.39 0.763 2.63 0.113 0.367 0.759 0.12 1.12 0.549 2.32 0.359 0.319 0.261 0.583 1.43 0.778 2.71 PRS_PLINK_1.99526231496888e.08 FALSE 733.2 Cyst of bone Both 4 49 14 musculoskeletal darkolivegreen 49, 4 9, 0 12, 1 12, 2 12, 0 -0.652 0.75 0.385 0.415 0.521 0.0776 3.11 0.00905 1.73 0.996 0.002 1.01 0.00364 145 0.402 1.36 0.767 0.115 1.49 0.0509 104 PRS_PLINK_1.99526231496888e.08 TRUE 733.4 Aseptic necrosis of bone Both 15 74 14 musculoskeletal darkolivegreen 74, 15 12, 1 22, 3 14, 2 19, 7 0.432 0.38 0.255 0.593 1.54 0.747 3.38 0.569 1.26 0.652 0.186 1.77 0.0684 43.5 0.495 1.15 0.667 0.176 1.64 0.0535 39.5 0.579 1.13 0.608 0.216 1.79 0.139 30.1 PRS_PLINK_1.99526231496888e.08 TRUE 733.6 Costochondritis Both 33 101 14 musculoskeletal darkolivegreen 101, 33 17, 3 25, 7 26, 14 24, 8 0.0536 0.133 0.688 0.162 1.06 0.815 1.34 0.29 0.821 0.724 0.14 1.34 0.29 7.32 0.684 0.719 0.342 0.466 1.98 0.534 9.08 0.699 0.834 0.402 0.396 2.01 0.408 11.8 PRS_PLINK_1.99526231496888e.08 TRUE 733.8 Malunion and nonunion of fracture Both 28 161 14 musculoskeletal darkolivegreen 161, 28 21, 3 51, 12 29, 6 40, 7 0.0848 0.206 0.681 0.167 1.09 0.669 1.55 -0.187 0.752 0.804 0.095 0.83 0.194 3.99 0.498 0.788 0.527 0.278 1.65 0.368 9.27 0.00761 0.753 0.992 0.004 1.01 0.238 4.97 PRS_PLINK_1.99526231496888e.08 TRUE 733.9 Chondromalacia Both 4 22 14 musculoskeletal darkolivegreen 22, 4 3, 0 6, 0 4, 4 6, 0 0.92 0.925 0.32 0.494 2.51 0.487 4620 -1.5 4.65 0.747 0.127 0.223 0.182 510 PRS_PLINK_1.99526231496888e.08 TRUE 735 Acquired foot deformities Both 165 688 14 musculoskeletal darkolivegreen 688, 165 102, 22 234, 60 110, 24 172, 46 0.0493 0.0846 0.56 0.252 1.05 0.88 1.23 0.054 0.286 0.85 0.07 1.06 0.609 1.87 0.0196 0.326 0.952 0.021 1.02 0.537 1.94 0.188 0.293 0.521 0.283 1.21 0.686 2.17 PRS_PLINK_1.99526231496888e.08 FALSE 735.1 Flat foot Both 41 135 14 musculoskeletal darkolivegreen 135, 41 22, 4 35, 9 32, 7 34, 16 0.0674 0.127 0.596 0.225 1.07 0.797 1.32 0.413 0.7 0.555 0.255 1.51 0.41 6.38 0.381 0.71 0.592 0.228 1.46 0.388 6.47 1.12 0.659 0.0881 1.055 3.08 0.945 12.3 PRS_PLINK_1.99526231496888e.08 TRUE 735.2 Acquired toe deformities Both 65 247 14 musculoskeletal darkolivegreen 247, 65 30, 5 62, 28 61, 13 62, 13 -0.0928 0.172 0.589 0.23 0.911 0.621 1.23 0.779 0.599 0.193 0.714 2.18 0.72 7.58 0.0347 0.587 0.953 0.021 1.04 0.334 3.49 -0.218 0.597 0.714 0.146 0.804 0.249 2.75 PRS_PLINK_1.99526231496888e.08 FALSE 735.21 Hammer toe (acquired) Both 31 148 14 musculoskeletal darkolivegreen 148, 31 16, 3 43, 12 31, 6 37, 8 0.0257 0.199 0.897 0.047 1.03 0.59 1.41 0.0526 0.755 0.944 0.025 1.05 0.256 5.21 -0.634 0.86 0.46 0.337 0.53 0.0655 3.13 -0.35 0.79 0.658 0.182 0.705 0.151 3.59 PRS_PLINK_1.99526231496888e.08 TRUE 735.23 Hallux rigidus Both 27 81 14 musculoskeletal darkolivegreen 81, 27 7, 2 21, 17 19, 5 20, 2 -0.254 0.364 0.485 0.315 0.775 0.369 1.58 0.589 1.02 0.563 0.25 1.8 0.28 17.1 -1.22 1.27 0.335 0.475 0.294 0.036 3.33 -1.13 1.25 0.367 0.436 0.322 0.0172 4.62 PRS_PLINK_1.99526231496888e.08 TRUE 735.3 Hallux valgus (Bunion) Both 87 384 14 musculoskeletal darkolivegreen 384, 87 52, 6 138, 37 54, 11 96, 25 0.121 0.109 0.266 0.575 1.13 0.902 1.38 0.627 0.46 0.173 0.761 1.87 0.795 5.03 0.405 0.517 0.434 0.362 1.5 0.547 4.42 0.493 0.473 0.297 0.527 1.64 0.667 4.5 PRS_PLINK_1.99526231496888e.08 FALSE 736 Other acquired deformities of limbs Both 128 597 14 musculoskeletal darkolivegreen 597, 128 81, 14 214, 45 88, 16 145, 41 0.135 0.0837 0.107 0.972 1.14 0.967 1.34 0.0922 0.337 0.784 0.105 1.1 0.577 2.18 0.0234 0.398 0.953 0.021 1.02 0.466 2.26 0.398 0.34 0.242 0.616 1.49 0.777 2.98 PRS_PLINK_1.99526231496888e.08 FALSE 736.1 Acquired deformities of forearm Both 2 15 14 musculoskeletal darkolivegreen 15, 2 2, 0 4, 1 3, 1 4, 0 -0.662 1.4 0.637 0.196 0.516 0.0069 5.44 -0.265 582 1 0 0.767 0.142 3.7 -0.326 72.8 0.996 0.002 0.722 1.41e-05 399000 PRS_PLINK_1.99526231496888e.08 TRUE 736.2 Acquired deformities of finger Both 6 54 14 musculoskeletal darkolivegreen 54, 6 10, 1 14, 2 12, 2 14, 1 0.554 0.325 0.0884 1.053 1.74 1.03 4.29 -1.04 1.38 0.45 0.347 0.353 0.00209 5.45 0.251 1.45 0.863 0.064 1.29 0.107 151 -0.131 1.18 0.912 0.04 0.877 0.0373 12.9 PRS_PLINK_1.99526231496888e.08 TRUE 736.3 Acquired deformities of hip Both 3 27 14 musculoskeletal darkolivegreen 27, 3 4, 0 8, 0 5, 1 7, 1 0.138 0.87 0.874 0.058 1.15 0.0943 204 -0.84 9.58 0.93 0.031 0.432 8.21e-05 2980 0.286 2.21 0.897 0.047 1.33 0.00379 87.2 PRS_PLINK_1.99526231496888e.08 TRUE 736.4 Genu valgum or varum (acquired) Both 11 53 14 musculoskeletal darkolivegreen 53, 11 7, 3 15, 4 11, 0 13, 1 -0.932 0.493 0.0586 1.232 0.394 0.139 0.971 -0.408 1.06 0.701 0.154 0.665 0.0862 5.42 -1.99 1.71 0.245 0.611 0.137 8.33e-05 1.98 -0.871 1.35 0.52 0.284 0.419 0.0104 6.22 PRS_PLINK_1.99526231496888e.08 TRUE 736.5 Acquired deformities of knee Both 8 40 14 musculoskeletal darkolivegreen 40, 8 6, 1 11, 3 9, 1 10, 1 -0.644 0.569 0.258 0.588 0.525 0.159 1.5 0.359 1.57 0.819 0.087 1.43 0.0724 54.2 -0.531 2.25 0.813 0.09 0.588 0.000634 31.2 0.898 1.57 0.568 0.246 2.46 0.121 838 PRS_PLINK_1.99526231496888e.08 TRUE 736.6 Unequal leg length (acquired) Both 14 79 14 musculoskeletal darkolivegreen 79, 14 12, 1 21, 4 18, 3 20, 5 0.0739 0.398 0.853 0.069 1.08 0.49 2.47 0.378 1.09 0.73 0.137 1.46 0.175 16 -0.0441 1.1 0.968 0.014 0.957 0.0514 11.7 0.00601 1.19 0.996 0.002 1.01 0.0938 18.6 PRS_PLINK_1.99526231496888e.08 TRUE 737 Curvature of spine Both 69 342 14 musculoskeletal darkolivegreen 342, 69 37, 3 90, 17 80, 22 86, 18 0.163 0.14 0.245 0.612 1.18 0.887 1.53 0.547 0.625 0.381 0.419 1.73 0.536 7.1 0.993 0.627 0.113 0.945 2.7 0.861 11 0.903 0.605 0.135 0.869 2.47 0.812 9.89 PRS_PLINK_1.99526231496888e.08 FALSE 737.1 Kyphosis (acquired) Both 14 99 14 musculoskeletal darkolivegreen 99, 14 5, 0 27, 4 22, 4 25, 5 0.512 0.357 0.152 0.818 1.67 0.841 3.56 0.737 1.55 0.634 0.198 2.09 0.124 351 0.257 1.51 0.866 0.063 1.29 0.0816 169 0.914 1.57 0.559 0.253 2.5 0.224 356 PRS_PLINK_1.99526231496888e.08 TRUE 737.2 Lordosis (acquired) Both 2 17 14 musculoskeletal darkolivegreen 17, 2 0.646 0.708 0.362 0.441 1.91 0.517 33.5 PRS_PLINK_1.99526231496888e.08 TRUE 737.3 Kyphoscoliosis and scoliosis Both 54 266 14 musculoskeletal darkolivegreen 266, 54 32, 3 64, 14 67, 20 66, 11 0.0792 0.158 0.617 0.21 1.08 0.775 1.45 0.602 0.618 0.33 0.482 1.83 0.569 7.41 0.599 0.639 0.348 0.458 1.82 0.562 7.43 0.526 0.641 0.412 0.385 1.69 0.505 7.14 PRS_PLINK_1.99526231496888e.08 FALSE 738 Other acquired musculoskeletal deformity Both 72 508 14 musculoskeletal darkolivegreen 508, 72 61, 5 127, 19 127, 20 127, 24 0.198 0.13 0.128 0.891 1.22 0.954 1.58 0.442 0.513 0.39 0.409 1.56 0.587 4.77 0.505 0.506 0.318 0.498 1.66 0.64 4.99 0.691 0.497 0.164 0.784 2 0.785 5.93 PRS_PLINK_1.99526231496888e.08 FALSE 738.4 Acquired spondylolisthesis Both 34 164 14 musculoskeletal darkolivegreen 164, 34 15, 1 41, 9 42, 11 40, 13 0.714 0.262 0.00651 2.187 2.04 1.23 3.48 0.887 1.03 0.391 0.408 2.43 0.396 28.8 0.952 0.949 0.316 0.5 2.59 0.5 25.4 1.06 0.921 0.252 0.599 2.87 0.582 29 PRS_PLINK_1.99526231496888e.08 TRUE 739 Contracture of joint Both 20 136 14 musculoskeletal darkolivegreen 136, 20 17, 1 46, 5 22, 1 34, 6 0.131 0.142 0.358 0.446 1.14 0.827 1.45 -0.0983 0.999 0.922 0.035 0.906 0.126 11.2 0.223 1.2 0.852 0.069 1.25 0.0391 128 1.6 1.25 0.2 0.7 4.96 0.51 238 PRS_PLINK_1.99526231496888e.08 TRUE 740 Osteoarthrosis Both 468 796 14 musculoskeletal darkolivegreen 796, 468 114, 57 270, 164 130, 75 197, 123 0.0771 0.0642 0.23 0.639 1.08 0.951 1.22 0.0045 0.214 0.983 0.007 1 0.663 1.53 0.124 0.245 0.614 0.212 1.13 0.703 1.83 0.107 0.225 0.634 0.198 1.11 0.719 1.73 PRS_PLINK_1.99526231496888e.08 FALSE 740.1 Osteoarthritis; localized Both 252 663 14 musculoskeletal darkolivegreen 663, 252 105, 34 221, 89 108, 39 166, 66 0.13 0.0785 0.0978 1.01 1.14 0.973 1.32 0.12 0.266 0.651 0.186 1.13 0.676 1.91 0.132 0.3 0.659 0.181 1.14 0.638 2.05 0.204 0.277 0.461 0.337 1.23 0.719 2.12 PRS_PLINK_1.99526231496888e.08 FALSE 740.11 Osteoarthrosis, localized, primary Both 223 602 14 musculoskeletal darkolivegreen 602, 223 96, 33 205, 75 95, 35 149, 58 0.085 0.0879 0.334 0.477 1.09 0.908 1.28 -0.0218 0.275 0.937 0.028 0.978 0.575 1.68 0.121 0.311 0.697 0.157 1.13 0.618 2.07 0.078 0.288 0.787 0.104 1.08 0.619 1.91 PRS_PLINK_1.99526231496888e.08 FALSE 740.12 Osteoarthrosis, localized, secondary Both 25 109 14 musculoskeletal darkolivegreen 109, 25 23, 9 34, 6 19, 3 27, 6 0.173 0.218 0.427 0.37 1.19 0.732 1.72 -1.15 0.759 0.129 0.89 0.316 0.0614 1.28 -0.931 1.03 0.365 0.438 0.394 0.0278 3.16 -0.337 0.65 0.604 0.219 0.714 0.201 2.48 PRS_PLINK_1.99526231496888e.08 TRUE 740.2 Osteoarthrosis, generalized Both 57 181 14 musculoskeletal darkolivegreen 181, 57 33, 9 49, 13 41, 17 45, 12 0.0273 0.219 0.901 0.045 1.03 0.673 1.57 0.0737 0.572 0.898 0.047 1.08 0.361 3.45 0.448 0.494 0.364 0.439 1.57 0.622 4.17 0.0501 0.565 0.929 0.032 1.05 0.354 3.28 PRS_PLINK_1.99526231496888e.08 FALSE 740.3 Osteoarthrosis involving more than one site, but not specified as generalized Both 14 47 14 musculoskeletal darkolivegreen 47, 14 8, 1 16, 4 7, 5 12, 3 0.199 0.517 0.7 0.155 1.22 0.455 3.32 1 1.49 0.501 0.3 2.72 0.222 81.8 0.249 1.51 0.869 0.061 1.28 0.0618 19400 0.231 1.69 0.891 0.05 1.26 0.00118 431 PRS_PLINK_1.99526231496888e.08 TRUE 740.9 Osteoarthrosis NOS Both 448 796 14 musculoskeletal darkolivegreen 796, 448 114, 55 270, 157 130, 73 197, 119 0.0815 0.0659 0.216 0.666 1.08 0.952 1.23 -0.00263 0.216 0.99 0.004 0.997 0.656 1.52 0.122 0.247 0.622 0.206 1.13 0.699 1.83 0.103 0.227 0.651 0.186 1.11 0.713 1.73 PRS_PLINK_1.99526231496888e.08 FALSE 741 Symptoms and disorders of the joints Both 349 809 14 musculoskeletal darkolivegreen 809, 349 118, 40 272, 127 133, 49 200, 97 0.0721 0.0711 0.311 0.507 1.07 0.934 1.23 0.247 0.226 0.274 0.562 1.28 0.828 2 0.0331 0.258 0.898 0.047 1.03 0.626 1.71 0.246 0.228 0.281 0.552 1.28 0.824 2.01 PRS_PLINK_1.99526231496888e.08 FALSE 741.1 Ankylosis of joint Both 6 57 14 musculoskeletal darkolivegreen 57, 6 8, 1 19, 4 9, 0 14, 1 -0.118 0.613 0.847 0.072 0.889 0.229 3.38 0.0681 1.19 0.954 0.02 1.07 0.131 15.2 -0.689 1.59 0.664 0.178 0.502 0.00092 108 -0.35 1.45 0.809 0.092 0.704 0.00913 18.2 PRS_PLINK_1.99526231496888e.08 TRUE 741.2 Stiffness of joint Both 64 295 14 musculoskeletal darkolivegreen 295, 64 33, 2 101, 29 45, 10 74, 16 0.104 0.16 0.517 0.287 1.11 0.807 1.51 1.7 0.747 0.0228 1.643 5.48 1.48 32.6 0.837 0.704 0.234 0.63 2.31 0.614 12 1.09 0.75 0.147 0.832 2.96 0.744 17.6 PRS_PLINK_1.99526231496888e.08 FALSE 741.3 Difficulty in walking Both 71 346 14 musculoskeletal darkolivegreen 346, 71 56, 9 119, 19 52, 8 87, 27 0.0662 0.143 0.643 0.191 1.07 0.792 1.39 -0.0532 0.452 0.906 0.043 0.948 0.398 2.4 -0.0893 0.516 0.863 0.064 0.915 0.325 2.53 0.513 0.427 0.23 0.638 1.67 0.74 4.03 PRS_PLINK_1.99526231496888e.08 FALSE 741.4 Joint effusions Both 129 542 14 musculoskeletal darkolivegreen 542, 129 76, 14 181, 50 88, 18 136, 38 0.0961 0.0965 0.319 0.496 1.1 0.906 1.32 0.468 0.347 0.177 0.752 1.6 0.83 3.24 0.0849 0.393 0.829 0.082 1.09 0.507 2.37 0.333 0.35 0.341 0.467 1.39 0.715 2.84 PRS_PLINK_1.99526231496888e.08 FALSE 741.5 Hemarthrosis Both 8 14 14 musculoskeletal darkolivegreen 14, 8 2, 0 3, 2 4, 0 3, 5 -0.203 0.919 0.825 0.084 0.816 0.109 7.67 0.107 318 1 0 1.11 0.765 1.8 -1.56 60.6 0.98 0.009 0.211 0.00428 0.26 PRS_PLINK_1.99526231496888e.08 TRUE 741.6 Villonodular synovitis Both 2 27 14 musculoskeletal darkolivegreen 27, 2 4, 2 7, 0 6, 0 7, 0 -0.571 0.811 0.481 0.318 0.565 0.0176 3.13 -1.12 1.77 0.529 0.277 0.327 0.00284 4.57 -0.244 2.93 0.934 0.03 0.783 0.000348 1910 -1.16 5.73 0.839 0.076 0.312 0.295 0.327 PRS_PLINK_1.99526231496888e.08 TRUE 742 Derangement of joint, non-traumatic Both 235 794 14 musculoskeletal darkolivegreen 794, 235 115, 26 270, 83 124, 31 199, 69 0.115 0.0699 0.1 0.999 1.12 0.976 1.28 0.359 0.265 0.175 0.758 1.43 0.863 2.44 0.0765 0.297 0.797 0.099 1.08 0.603 1.94 0.31 0.266 0.245 0.611 1.36 0.816 2.32 PRS_PLINK_1.99526231496888e.08 FALSE 742.1 Loose body in joint Both 6 37 14 musculoskeletal darkolivegreen 37, 6 5, 0 12, 4 6, 1 9, 1 0.316 0.593 0.593 0.227 1.37 0.441 5.41 0.644 1.67 0.7 0.155 1.9 0.00822 148 0.602 2.65 0.82 0.086 1.83 0.0128 556 0.242 3.2 0.94 0.027 1.27 0.000506 4690 PRS_PLINK_1.99526231496888e.08 TRUE 742.2 Pathological, developmental or recurrent dislocation Both 10 67 14 musculoskeletal darkolivegreen 67, 10 8, 0 22, 4 11, 4 17, 1 0.0039 0.419 0.993 0.003 1 0.439 2.38 2.18 1.91 0.255 0.594 8.84 0.419 1830 1.61 1.43 0.26 0.585 5.01 0.509 499 -0.793 1.73 0.647 0.189 0.453 0.00125 70.4 PRS_PLINK_1.99526231496888e.08 TRUE 742.8 Articular cartilage disorder Both 15 70 14 musculoskeletal darkolivegreen 70, 15 10, 1 27, 3 7, 3 18, 5 0.0543 0.37 0.883 0.054 1.06 0.524 2.15 1.22 1.43 0.392 0.407 3.4 0.24 369 1.28 1.26 0.308 0.512 3.6 0.407 134 1.17 1.19 0.326 0.487 3.23 0.4 71 PRS_PLINK_1.99526231496888e.08 TRUE 742.9 Other derangement of joint Both 222 786 14 musculoskeletal darkolivegreen 786, 222 112, 26 268, 79 126, 27 195, 65 0.114 0.0709 0.107 0.971 1.12 0.973 1.28 0.283 0.267 0.289 0.539 1.33 0.796 2.27 -0.102 0.307 0.74 0.131 0.903 0.494 1.65 0.266 0.269 0.323 0.491 1.3 0.777 2.23 PRS_PLINK_1.99526231496888e.08 FALSE 743 Osteoporosis, osteopenia and pathological fracture Both 368 880 14 musculoskeletal darkolivegreen 880, 368 121, 45 288, 143 152, 56 220, 90 -0.00555 0.0712 0.938 0.028 0.994 0.859 1.14 0.199 0.227 0.38 0.42 1.22 0.788 1.91 -0.104 0.266 0.696 0.157 0.901 0.537 1.51 0.0131 0.232 0.955 0.02 1.01 0.647 1.6 PRS_PLINK_1.99526231496888e.08 FALSE 743.1 Osteoporosis Both 141 378 14 musculoskeletal darkolivegreen 378, 141 55, 16 125, 53 63, 23 95, 35 0.0594 0.107 0.579 0.237 1.06 0.847 1.29 0.423 0.364 0.245 0.61 1.53 0.768 3.16 0.22 0.4 0.581 0.236 1.25 0.581 2.73 0.218 0.36 0.546 0.263 1.24 0.626 2.54 PRS_PLINK_1.99526231496888e.08 FALSE 743.11 Osteoporosis NOS Both 140 376 14 musculoskeletal darkolivegreen 376, 140 54, 16 126, 53 63, 23 93, 34 0.0588 0.107 0.583 0.234 1.06 0.847 1.29 0.338 0.363 0.352 0.453 1.4 0.705 2.9 0.186 0.401 0.642 0.192 1.2 0.561 2.64 0.173 0.362 0.633 0.199 1.19 0.596 2.43 PRS_PLINK_1.99526231496888e.08 FALSE 743.12 Senile osteoporosis Both 34 55 14 musculoskeletal darkolivegreen 55, 34 9, 9 15, 9 12, 12 14, 3 0.26 0.345 0.452 0.345 1.3 0.685 2.56 -0.702 0.8 0.38 0.42 0.496 0.0883 2.13 0.259 0.8 0.746 0.127 1.3 0.3 5.96 -2.04 1.06 0.0534 1.273 0.13 0.00811 0.827 PRS_PLINK_1.99526231496888e.08 TRUE 743.13 Other specified osteoporosis Both 21 40 14 musculoskeletal darkolivegreen 40, 21 3, 0 10, 6 10, 6 10, 8 0.174 0.255 0.495 0.305 1.19 0.757 1.92 5.48 4.45 0.218 0.661 240 0.123 6.76e+10 -0.217 2.74 0.937 0.028 0.805 0.00991 133 2.04 2.98 0.494 0.307 7.67 0.0869 17300 PRS_PLINK_1.99526231496888e.08 TRUE 743.2 Pathologic fracture Both 47 150 14 musculoskeletal darkolivegreen 150, 47 21, 6 48, 23 26, 7 38, 7 -0.138 0.207 0.505 0.297 0.871 0.563 1.26 0.331 0.545 0.544 0.265 1.39 0.514 4.12 0.461 0.685 0.501 0.3 1.59 0.445 6.59 -0.114 0.665 0.864 0.064 0.892 0.255 3.24 PRS_PLINK_1.99526231496888e.08 TRUE 743.21 Pathologic fracture of vertebrae Both 17 63 14 musculoskeletal darkolivegreen 63, 17 11, 1 22, 7 9, 3 16, 3 -0.147 0.29 0.612 0.213 0.863 0.415 1.38 0.928 0.993 0.35 0.456 2.53 0.449 27.8 2.35 1.71 0.171 0.768 10.5 0.686 99400 -0.0662 1.28 0.959 0.018 0.936 0.0713 38.9 PRS_PLINK_1.99526231496888e.08 TRUE 743.22 Pathologic fracture of femur Both 9 19 14 musculoskeletal darkolivegreen 19, 9 1, 0 5, 4 4, 4 5, 1 -0.146 0.302 0.627 0.203 0.864 0.496 1.39 7.47 12.8 0.56 0.252 1760 5.43e-07 2600 2.27 6.25 0.717 0.145 9.69 0.016 12400 0.115 30.3 0.997 0.001 1.12 0.0695 18.2 PRS_PLINK_1.99526231496888e.08 TRUE 743.4 Stress fracture Both 38 130 14 musculoskeletal darkolivegreen 130, 38 18, 5 37, 15 27, 8 33, 6 -0.122 0.243 0.616 0.21 0.885 0.552 1.42 0.214 0.614 0.727 0.138 1.24 0.402 4.19 -0.0102 0.705 0.988 0.005 0.99 0.259 4.04 -0.599 0.724 0.408 0.389 0.55 0.124 2.26 PRS_PLINK_1.99526231496888e.08 TRUE 743.9 Osteopenia or other disorder of bone and cartilage Both 300 816 14 musculoskeletal darkolivegreen 816, 300 114, 38 269, 116 142, 45 201, 80 0.0277 0.0763 0.716 0.145 1.03 0.879 1.18 0.191 0.242 0.43 0.366 1.21 0.759 1.96 -0.22 0.296 0.459 0.338 0.803 0.449 1.43 0.0812 0.247 0.743 0.129 1.08 0.672 1.77 PRS_PLINK_1.99526231496888e.08 FALSE 745 Pain in joint Both 823 446 14 musculoskeletal darkolivegreen 446, 823 69, 105 149, 283 74, 116 110, 229 0.0396 0.0609 0.516 0.287 1.04 0.927 1.18 0.103 0.197 0.601 0.221 1.11 0.754 1.62 -0.0226 0.228 0.921 0.036 0.978 0.628 1.52 0.208 0.203 0.306 0.514 1.23 0.828 1.82 PRS_PLINK_1.99526231496888e.08 FALSE 747 Cardiac and circulatory congenital anomalies Both 87 573 15 congenital anomalies mediumspringgreen 573, 87 81, 8 195, 28 91, 14 143, 25 0.0596 0.11 0.59 0.229 1.06 0.832 1.29 0.23 0.411 0.575 0.24 1.26 0.573 3.03 0.314 0.448 0.484 0.316 1.37 0.568 3.47 0.603 0.433 0.164 0.786 1.83 0.802 4.59 PRS_PLINK_1.99526231496888e.08 FALSE 747.1 Cardiac congenital anomalies Both 63 425 15 congenital anomalies mediumspringgreen 425, 63 57, 6 148, 18 62, 10 105, 19 0.00714 0.135 0.958 0.019 1.01 0.732 1.27 0.101 0.482 0.835 0.079 1.11 0.44 3.11 0.181 0.535 0.735 0.134 1.2 0.419 3.6 0.758 0.515 0.141 0.85 2.13 0.809 6.49 PRS_PLINK_1.99526231496888e.08 FALSE 747.11 Cardiac shunt/ heart septal defect Both 26 203 15 congenital anomalies mediumspringgreen 203, 26 31, 2 70, 7 30, 6 51, 7 0.0299 0.174 0.864 0.064 1.03 0.617 1.34 0.828 0.819 0.312 0.506 2.29 0.497 15.9 1.19 0.825 0.149 0.826 3.29 0.696 23.7 0.459 0.762 0.547 0.262 1.58 0.349 9.25 PRS_PLINK_1.99526231496888e.08 TRUE 747.12 Valvular heart disease/ heart chambers Both 23 133 15 congenital anomalies mediumspringgreen 133, 23 25, 4 50, 5 16, 3 33, 6 -0.333 0.311 0.285 0.545 0.717 0.38 1.31 -0.631 0.713 0.376 0.425 0.532 0.119 2.33 -0.388 0.94 0.68 0.167 0.679 0.0966 3.94 0.12 0.731 0.869 0.061 1.13 0.274 4.96 PRS_PLINK_1.99526231496888e.08 TRUE 747.13 Congenital anomalies of great vessels Both 14 76 15 congenital anomalies mediumspringgreen 76, 14 7, 1 20, 7 18, 3 19, 2 -0.0898 0.379 0.813 0.09 0.914 0.424 1.94 1.3 1.24 0.297 0.528 3.66 0.437 71.7 0.183 1.34 0.892 0.05 1.2 0.0987 39.2 0.718 1.38 0.603 0.22 2.05 0.156 41.7 PRS_PLINK_1.99526231496888e.08 TRUE 747.2 Congenital anomalies of peripheral vascular system Both 27 162 15 congenital anomalies mediumspringgreen 162, 27 22, 2 55, 11 26, 5 39, 5 0.15 0.23 0.515 0.288 1.16 0.719 1.79 0.416 0.741 0.574 0.241 1.52 0.383 8.33 0.717 1.01 0.479 0.32 2.05 0.307 28.9 0.0269 0.796 0.973 0.012 1.03 0.212 6.11 PRS_PLINK_1.99526231496888e.08 TRUE 748 Anomalies of respiratory system, congenital Both 4 37 15 congenital anomalies mediumspringgreen 37, 4 6, 0 9, 1 9, 0 9, 2 1 0.752 0.181 0.742 2.73 0.683 38.1 0.179 1.96 0.927 0.033 1.2 0.0037 64.3 0.776 1.78 0.663 0.179 2.17 0.0585 7060 PRS_PLINK_1.99526231496888e.08 TRUE 749 Congenital anomalies of face and neck Both 28 145 15 congenital anomalies mediumspringgreen 145, 28 24, 4 45, 10 27, 2 36, 9 0.139 0.16 0.384 0.416 1.15 0.847 1.54 0.114 0.681 0.867 0.062 1.12 0.305 4.56 -1.48 1.09 0.174 0.759 0.227 0.00803 1.66 0.728 0.682 0.286 0.544 2.07 0.586 8.66 PRS_PLINK_1.99526231496888e.08 TRUE 749.1 Cleft palate Both 3 22 15 congenital anomalies mediumspringgreen 22, 3 6, 0 4, 1 5, 0 6, 1 0.0896 0.792 0.91 0.041 1.09 0.262 11.3 2.7 3.15 0.392 0.407 14.8 0.173 34000 0.41 2.15 0.849 0.071 1.51 0.0479 46.4 PRS_PLINK_1.99526231496888e.08 TRUE 749.2 Congenital anomalies of skull and face bones Both 3 31 15 congenital anomalies mediumspringgreen 31, 3 6, 1 11, 0 4, 0 8, 2 -0.414 0.524 0.429 0.367 0.661 0.00128 1.91 -1.55 1.88 0.41 0.387 0.213 0.00041 7.62 -0.0587 2.83 0.983 0.007 0.943 0.00301 133 -1.16 2.11 0.582 0.235 0.314 2e-11 204 PRS_PLINK_1.99526231496888e.08 TRUE 750 Digestive congenital anomalies Both 46 235 15 congenital anomalies mediumspringgreen 235, 46 31, 5 82, 14 34, 9 59, 11 0.00973 0.151 0.949 0.023 1.01 0.751 1.35 0.164 0.593 0.782 0.107 1.18 0.387 4.14 0.684 0.639 0.284 0.547 1.98 0.602 7.34 -0.194 0.626 0.756 0.121 0.823 0.242 2.91 PRS_PLINK_1.99526231496888e.08 TRUE 750.1 Upper gastrointestinal congenital anomalies Both 12 79 15 congenital anomalies mediumspringgreen 79, 12 10, 2 20, 1 19, 3 20, 3 0.0672 0.209 0.748 0.126 1.07 0.73 1.6 0.000441 1.41 1 0 1 0.000541 101 0.482 1.3 0.71 0.149 1.62 0.134 61.5 -0.794 1.42 0.577 0.239 0.452 0.0176 7.86 PRS_PLINK_1.99526231496888e.08 TRUE 750.11 Esophageal atresia/tracheoesophageal fistula Both 4 23 15 congenital anomalies mediumspringgreen 23, 4 4, 2 6, 1 6, 1 5, 0 0.0388 0.433 0.929 0.032 1.04 0.441 2.51 -0.921 2.81 0.744 0.129 0.398 0.000745 19200 -0.144 2.03 0.943 0.025 0.866 0.0023 52.3 -1.9 3.39 0.575 0.24 0.15 7.28e-05 18.2 PRS_PLINK_1.99526231496888e.08 TRUE 750.13 Congenital anomalies of mouth/tongue Both 4 24 15 congenital anomalies mediumspringgreen 24, 4 3, 0 6, 0 6, 1 6, 1 0.118 0.267 0.657 0.182 1.13 0.739 1.83 -0.104 3.26 0.975 0.011 0.901 0.00638 87.1 2.94 60.6 0.961 0.017 19 5.28e-10 7.64e+11 PRS_PLINK_1.99526231496888e.08 TRUE 750.14 Congenital anomalies of esophagus Both 4 18 15 congenital anomalies mediumspringgreen 18, 4 4, 2 4, 0 5, 1 4, 0 -1.37 1.07 0.202 0.695 0.255 0.0131 1.7 -0.347 1.83 0.849 0.071 0.707 0.638 0.808 1.95 3.03 0.52 0.284 7.01 0.0642 2180 -1.32 3.44 0.702 0.154 0.267 2.15e-06 27 PRS_PLINK_1.99526231496888e.08 TRUE 750.15 Congenital anomalies of stomach Both 2 17 15 congenital anomalies mediumspringgreen 17, 2 2, 0 5, 0 3, 0 4, 1 -0.254 1.21 0.834 0.079 0.776 0.0351 8.35 0.0899 382 1 0 1.09 0.619 1.72 PRS_PLINK_1.99526231496888e.08 TRUE 750.2 Lower gastrointestinal congenital anomalies Both 32 156 15 congenital anomalies mediumspringgreen 156, 32 27, 3 49, 10 29, 6 39, 9 -0.0974 0.248 0.694 0.158 0.907 0.551 1.46 0.611 0.721 0.397 0.401 1.84 0.482 9.08 0.354 0.685 0.606 0.218 1.42 0.388 5.94 0.258 0.712 0.717 0.144 1.29 0.331 5.93 PRS_PLINK_1.99526231496888e.08 TRUE 750.21 Congenital anomalies of intestine Both 15 88 15 congenital anomalies mediumspringgreen 88, 15 17, 0 23, 4 21, 5 22, 5 0.25 0.401 0.532 0.274 1.28 0.598 2.97 2.3 1.57 0.143 0.844 9.97 0.679 10900000 1.94 1.35 0.151 0.822 6.96 0.722 892 2.23 1.91 0.243 0.615 9.34 0.305 13900 PRS_PLINK_1.99526231496888e.08 TRUE 750.22 Congenital anomaly of gallbladder, bile ducts, liver, pancreas Both 18 70 15 congenital anomalies mediumspringgreen 70, 18 13, 3 17, 3 17, 5 17, 4 -0.313 0.348 0.368 0.434 0.731 0.37 1.43 -0.355 0.973 0.715 0.145 0.701 0.0991 4.56 0.0417 0.868 0.962 0.017 1.04 0.208 5.38 0.181 0.889 0.838 0.077 1.2 0.222 6.93 PRS_PLINK_1.99526231496888e.08 TRUE 751 Genitourinary congenital anomalies Both 111 530 15 congenital anomalies mediumspringgreen 530, 111 69, 18 169, 42 94, 14 133, 31 0.0447 0.0981 0.648 0.188 1.05 0.854 1.25 -0.0476 0.322 0.883 0.054 0.954 0.515 1.82 -0.45 0.394 0.253 0.596 0.637 0.29 1.38 -0.222 0.34 0.514 0.289 0.801 0.414 1.57 PRS_PLINK_1.99526231496888e.08 FALSE 751.1 Congenital anomalies of genital organs Both 65 225 15 congenital anomalies mediumspringgreen 225, 65 31, 12 76, 24 36, 8 56, 19 0.207 0.192 0.282 0.549 1.23 0.849 1.8 -0.41 0.432 0.343 0.465 0.664 0.289 1.54 -0.715 0.576 0.214 0.669 0.489 0.15 1.46 -0.0577 0.448 0.897 0.047 0.944 0.406 2.25 PRS_PLINK_1.99526231496888e.08 FALSE 751.11 Congenital anomalies of female genital organs Female 58 202 15 congenital anomalies mediumspringgreen 202, 58 29, 11 68, 24 32, 6 51, 15 0.0186 0.171 0.914 0.039 1.02 0.707 1.39 -0.256 0.441 0.562 0.251 0.774 0.335 1.83 -0.916 0.623 0.142 0.849 0.4 0.11 1.29 -0.223 0.471 0.635 0.197 0.8 0.326 1.99 PRS_PLINK_1.99526231496888e.08 FALSE 751.12 Congenital anomalies of male genital organs Male 7 20 15 congenital anomalies mediumspringgreen 20, 7 2, 1 5, 0 5, 2 5, 4 2.32 1.18 0.0498 1.303 10.1 1.36 852 -1.26 1930 0.999 0 0.284 0.0264 0.526 3.04 7.86 0.699 0.155 20.8 1.4e-05 25800000 3.21 2.62 0.22 0.658 24.8 0.644 116000 PRS_PLINK_1.99526231496888e.08 TRUE 751.2 Congenital anomalies of urinary system Both 50 308 15 congenital anomalies mediumspringgreen 308, 50 40, 8 100, 18 55, 5 76, 15 0.133 0.151 0.378 0.422 1.14 0.862 1.55 0.21 0.489 0.668 0.175 1.23 0.492 3.36 -0.652 0.615 0.289 0.54 0.521 0.14 1.75 -0.0548 0.486 0.91 0.041 0.947 0.372 2.52 PRS_PLINK_1.99526231496888e.08 TRUE 751.21 Cystic kidney disease Both 35 205 15 congenital anomalies mediumspringgreen 205, 35 25, 5 73, 17 29, 4 51, 6 -0.163 0.224 0.467 0.331 0.85 0.528 1.28 0.476 0.583 0.414 0.383 1.61 0.554 5.41 -0.113 0.786 0.886 0.053 0.893 0.181 4.41 -0.607 0.678 0.37 0.432 0.545 0.135 2.1 PRS_PLINK_1.99526231496888e.08 TRUE 751.22 Other specified congenital anomalies of kidney Both 8 70 15 congenital anomalies mediumspringgreen 70, 8 11, 1 20, 1 14, 1 18, 4 0.403 0.475 0.395 0.403 1.5 0.598 4.59 -0.523 1.23 0.671 0.173 0.593 0.00484 9.27 -0.766 1.53 0.617 0.21 0.465 0.00641 12 0.369 1.2 0.759 0.12 1.45 0.173 17.4 PRS_PLINK_1.99526231496888e.08 TRUE 751.3 Obstructive genitourinary defect Both 6 45 15 congenital anomalies mediumspringgreen 45, 6 7, 1 14, 1 8, 1 11, 2 0.56 0.828 0.499 0.302 1.75 0.314 14.7 -1.45 1.49 0.333 0.478 0.236 0.00221 3.99 0.266 1.9 0.889 0.051 1.3 0.0447 197 -0.161 1.56 0.918 0.037 0.851 0.0526 24.9 PRS_PLINK_1.99526231496888e.08 TRUE 752 Nervous system congenital anomalies Both 43 263 15 congenital anomalies mediumspringgreen 263, 43 38, 6 88, 15 45, 4 64, 14 0.0277 0.128 0.828 0.082 1.03 0.755 1.27 0.106 0.505 0.833 0.079 1.11 0.428 3.19 -0.253 0.63 0.688 0.162 0.777 0.209 2.73 0.525 0.559 0.347 0.459 1.69 0.596 5.4 PRS_PLINK_1.99526231496888e.08 TRUE 752.1 Neural tube defects Both 31 181 15 congenital anomalies mediumspringgreen 181, 31 27, 5 60, 10 30, 1 45, 12 0.0371 0.159 0.815 0.089 1.04 0.721 1.36 -0.0212 0.599 0.972 0.012 0.979 0.315 3.34 -1.1 0.902 0.221 0.655 0.332 0.0346 1.87 0.492 0.63 0.435 0.362 1.64 0.511 6.02 PRS_PLINK_1.99526231496888e.08 TRUE 752.11 Spina bifida Both 8 51 15 congenital anomalies mediumspringgreen 51, 8 7, 1 17, 3 8, 0 13, 2 0.0361 0.297 0.903 0.044 1.04 0.322 1.59 -0.458 1.25 0.713 0.147 0.633 0.0384 7.71 -0.6 1.83 0.743 0.129 0.549 0.00387 47.5 0.32 1.41 0.821 0.086 1.38 0.0151 247 PRS_PLINK_1.99526231496888e.08 TRUE 752.2 Other specified congenital anomalies of nervous system Both 10 85 15 congenital anomalies mediumspringgreen 85, 10 16, 1 23, 5 19, 3 21, 0 -0.0669 0.206 0.746 0.127 0.935 0.327 1.24 1.02 0.964 0.29 0.537 2.77 0.514 28.4 2.78 1.73 0.107 0.972 16.2 0.787 27800 -0.278 1.2 0.817 0.088 0.757 0.0107 29.2 PRS_PLINK_1.99526231496888e.08 TRUE 753 Congenital anomalies of the eye Both 13 61 15 congenital anomalies mediumspringgreen 61, 13 8, 1 21, 2 9, 2 15, 7 0.508 0.313 0.105 0.98 1.66 0.898 3.14 -0.541 1.8 0.764 0.117 0.582 0.00242 655 0.299 2.09 0.886 0.052 1.35 1.37e-05 185000 1.16 1.65 0.481 0.318 3.19 0.13 12900000 PRS_PLINK_1.99526231496888e.08 TRUE 753.1 Congenital cataract and lens anomalies Both 4 12 15 congenital anomalies mediumspringgreen 12, 4 1, 1 3, 0 3, 1 3, 2 1.64 2.05 0.424 0.373 5.14 0.0815 366000 -0.399 765 1 0 0.671 0.63 1.37 0.706 716 0.999 0 2.03 0.868 2.07 1.12 35700000 1 0 3.07 0.953 236 PRS_PLINK_1.99526231496888e.08 TRUE 753.2 Congenital anomalies of posterior segment of eye Both 4 11 15 congenital anomalies mediumspringgreen 11, 4 1, 0 4, 1 1, 0 3, 2 1.24 0.952 0.191 0.718 3.47 0.893 33 -0.00772 14.2 1 0 0.992 0.929 1.04 0.465 3130 1 0 1.59 0.34 2.41 PRS_PLINK_1.99526231496888e.08 TRUE 754 Congenital musculoskeletal deformities of spine Both 50 224 15 congenital anomalies mediumspringgreen 224, 50 26, 5 74, 16 37, 8 56, 20 0.381 0.188 0.0431 1.365 1.46 1.04 2.21 0.159 0.578 0.783 0.106 1.17 0.393 3.91 0.587 0.69 0.395 0.404 1.8 0.486 8.01 0.621 0.588 0.291 0.536 1.86 0.627 6.43 PRS_PLINK_1.99526231496888e.08 TRUE 754.1 Lumbosacral spondylolysis, congenital Both 10 33 15 congenital anomalies mediumspringgreen 33, 10 6, 0 11, 3 5, 3 8, 4 0.0848 0.28 0.762 0.118 1.09 0.645 1.78 1.15 1.92 0.549 0.261 3.15 0.00189 6680000 2.53 2.48 0.308 0.512 12.6 0.194 3550 1.61 2.11 0.446 0.351 5.01 0.13 1130 PRS_PLINK_1.99526231496888e.08 TRUE 754.2 Spondylolisthesis, congenital Both 23 94 15 congenital anomalies mediumspringgreen 94, 23 12, 3 24, 10 22, 4 24, 6 0.136 0.229 0.554 0.257 1.15 0.709 1.73 0.696 0.901 0.44 0.357 2.01 0.405 16.4 0.197 1.15 0.863 0.064 1.22 0.132 29.9 -0.233 0.976 0.811 0.091 0.792 0.133 6.09 PRS_PLINK_1.99526231496888e.08 TRUE 755 Congenital anomalies of limbs Both 44 235 15 congenital anomalies mediumspringgreen 235, 44 18, 1 68, 9 49, 12 59, 14 0.184 0.133 0.168 0.775 1.2 0.925 1.54 0.232 0.907 0.798 0.098 1.26 0.239 13.1 1.72 1.16 0.138 0.86 5.57 0.764 178 1.37 1.09 0.208 0.681 3.95 0.555 70.6 PRS_PLINK_1.99526231496888e.08 TRUE 755.1 Congenital deformities of feet Both 24 112 15 congenital anomalies mediumspringgreen 112, 24 13, 0 36, 4 19, 4 28, 11 0.396 0.227 0.0816 1.088 1.49 1.03 2.7 1.87 1.41 0.187 0.729 6.47 0.539 3450000 0.327 1.53 0.831 0.081 1.39 0.0376 157 1.56 1.45 0.28 0.553 4.77 0.393 679 PRS_PLINK_1.99526231496888e.08 TRUE 755.4 Congenital anomalies of upper limb, including shoulder girdle Both 5 14 15 congenital anomalies mediumspringgreen 14, 5 2, 1 3, 1 3, 3 4, 0 -2.11 1.79 0.237 0.626 0.121 0.00025 10.2 -0.151 209 0.999 0 0.86 0.339 2.64 -1.13 208 0.996 0.002 0.324 0.302 0.348 0.16 20600000 1 0 1.17 0.177 3.66 PRS_PLINK_1.99526231496888e.08 TRUE 755.6 Other congenital anomalies of lower limb, including pelvic girdle Both 19 104 15 congenital anomalies mediumspringgreen 104, 19 4, 1 26, 3 26, 8 26, 3 -0.0395 0.294 0.893 0.049 0.961 0.539 1.72 -1.13 1.65 0.492 0.308 0.322 0.00735 12.6 1.13 1.66 0.497 0.303 3.09 0.213 542 1.8 1.99 0.365 0.438 6.05 0.237 435000 PRS_PLINK_1.99526231496888e.08 TRUE 755.61 Congenital hip dysplasia and deformity Both 10 86 15 congenital anomalies mediumspringgreen 86, 10 5, 0 21, 1 21, 5 22, 2 -0.0448 0.394 0.909 0.041 0.956 0.429 2.15 -0.506 1.77 0.776 0.11 0.603 0.00398 399 0.413 1.81 0.819 0.087 1.51 0.0451 254 0.132 1.78 0.941 0.026 1.14 0.0016 1310 PRS_PLINK_1.99526231496888e.08 TRUE 756 Other congenital musculoskeletal anomalies Both 63 374 15 congenital anomalies mediumspringgreen 374, 63 52, 10 123, 28 66, 6 91, 13 -0.0914 0.171 0.594 0.226 0.913 0.649 1.28 0.00396 0.413 0.992 0.003 1 0.458 2.32 -0.936 0.542 0.0839 1.076 0.392 0.123 1.14 -0.412 0.461 0.372 0.43 0.663 0.266 1.67 PRS_PLINK_1.99526231496888e.08 FALSE 756.1 Congenital anomalies of abdominal wall; diaphram Both 5 33 15 congenital anomalies mediumspringgreen 33, 5 7, 0 9, 2 7, 0 8, 2 -0.27 0.449 0.548 0.262 0.763 0.311 1.58 0.016 1.8 0.993 0.003 1.02 0.00524 193 0.958 1.51 0.524 0.28 2.61 0.235 11900 PRS_PLINK_1.99526231496888e.08 TRUE 756.2 Pectus and other congenital anomalies of ribs/sternum Both 3 19 15 congenital anomalies mediumspringgreen 19, 3 2, 1 5, 1 4, 0 5, 1 -0.0306 0.74 0.967 0.015 0.97 0.185 4.44 0.0671 2.19 0.976 0.011 1.07 0.884 1.09 0.039 21.8 0.999 0.001 1.04 1.02 1.06 -2.25 80.4 0.978 0.01 0.105 0.0917 0.12 PRS_PLINK_1.99526231496888e.08 TRUE 756.3 Congenital anomalies of muscle, tendon, fascia, and connective tissue Both 13 95 15 congenital anomalies mediumspringgreen 95, 13 12, 1 35, 6 11, 2 24, 2 0.149 0.334 0.655 0.184 1.16 0.557 2.21 1.75 1.5 0.244 0.613 5.75 0.442 29100 1.65 1.58 0.298 0.526 5.18 0.343 667 0.893 1.71 0.602 0.221 2.44 0.0896 1860 PRS_PLINK_1.99526231496888e.08 TRUE 756.5 Congenital osteodystrophies Both 42 249 15 congenital anomalies mediumspringgreen 249, 42 34, 7 79, 21 46, 4 61, 5 -0.268 0.206 0.192 0.716 0.765 0.498 1.13 0.177 0.498 0.723 0.141 1.19 0.466 3.3 -0.988 0.664 0.137 0.865 0.372 0.0875 1.35 -0.777 0.616 0.207 0.684 0.46 0.13 1.57 PRS_PLINK_1.99526231496888e.08 TRUE 757 Congenital anomalies of the integument Both 18 99 15 congenital anomalies mediumspringgreen 99, 18 15, 5 34, 6 15, 3 25, 3 -0.187 0.354 0.597 0.224 0.829 0.407 1.67 -0.819 0.716 0.252 0.598 0.441 0.0954 1.78 -0.706 0.885 0.425 0.371 0.494 0.076 2.4 -0.616 0.785 0.433 0.364 0.54 0.112 2.4 PRS_PLINK_1.99526231496888e.08 TRUE 758 Chromosomal anomalies and genetic disorders Both 18 74 15 congenital anomalies mediumspringgreen 74, 18 13, 2 25, 5 10, 3 19, 8 0.827 0.417 0.0473 1.325 2.29 1.07 5.78 -0.11 1.01 0.913 0.039 0.896 0.117 6.37 -0.757 1.32 0.566 0.247 0.469 0.000918 7.18 0.542 0.958 0.571 0.243 1.72 0.288 14.1 PRS_PLINK_1.99526231496888e.08 TRUE 758.1 Chromosomal anomalies Both 18 61 15 congenital anomalies mediumspringgreen 61, 18 11, 2 14, 4 15, 4 15, 8 0.765 0.435 0.0787 1.104 2.15 1.01 5.64 1.1 1.51 0.468 0.33 3 0.183 35.4 -1.15 1.39 0.41 0.388 0.318 1.33e-05 6.92 0.256 1.07 0.811 0.091 1.29 0.189 9.91 PRS_PLINK_1.99526231496888e.08 TRUE 759 Other and unspecified congenital anomalies Both 40 206 15 congenital anomalies mediumspringgreen 206, 40 32, 1 69, 11 29, 5 52, 18 0.309 0.193 0.109 0.964 1.36 0.962 2.05 1.22 0.898 0.174 0.761 3.39 0.665 38 2.16 1.24 0.08 1.097 8.7 0.89 1070 1.92 0.828 0.0205 1.689 6.82 1.58 63.3 PRS_PLINK_1.99526231496888e.08 TRUE 759.1 Anomalies of endocrine glands, congenital Both 6 26 15 congenital anomalies mediumspringgreen 26, 6 4, 0 6, 1 6, 1 7, 3 0.771 0.705 0.274 0.563 2.16 0.666 11.6 1.32 4.12 0.749 0.125 3.74 0.0233 787 -0.944 13.1 0.942 0.026 0.389 0.344 0.478 -2.05 4.51 0.65 0.187 0.129 1.97e-06 182 PRS_PLINK_1.99526231496888e.08 TRUE 760 Back pain Both 734 535 17 symptoms purple 535, 734 84, 94 177, 251 91, 99 132, 207 0.0298 0.0583 0.609 0.215 1.03 0.921 1.16 0.15 0.189 0.428 0.369 1.16 0.804 1.68 -0.0623 0.224 0.781 0.108 0.94 0.609 1.45 0.251 0.196 0.201 0.697 1.29 0.878 1.88 PRS_PLINK_1.99526231496888e.08 FALSE 761 Cervicalgia Both 373 891 17 symptoms purple 891, 373 140, 45 304, 116 145, 61 218, 102 0.0662 0.0619 0.285 0.545 1.07 0.945 1.2 0.136 0.211 0.519 0.285 1.15 0.764 1.74 0.254 0.243 0.297 0.527 1.29 0.805 2.08 0.305 0.218 0.162 0.791 1.36 0.891 2.08 PRS_PLINK_1.99526231496888e.08 FALSE 763 Thoracic or lumbosacral neuritis or radiculitis, unspecified Both 144 680 17 symptoms purple 680, 144 111, 16 229, 49 105, 27 170, 37 0.124 0.0881 0.16 0.796 1.13 0.943 1.33 0.305 0.311 0.328 0.484 1.36 0.748 2.56 0.532 0.351 0.129 0.889 1.7 0.863 3.45 0.361 0.328 0.27 0.569 1.44 0.764 2.79 PRS_PLINK_1.99526231496888e.08 FALSE 764 Sciatica Both 155 749 17 symptoms purple 749, 155 111, 23 254, 52 117, 25 186, 43 0.0945 0.0863 0.274 0.563 1.1 0.92 1.29 -0.0591 0.277 0.831 0.08 0.943 0.552 1.65 0.118 0.324 0.715 0.146 1.13 0.596 2.14 0.081 0.287 0.778 0.109 1.08 0.62 1.93 PRS_PLINK_1.99526231496888e.08 FALSE 765 Cervical radiculitis Both 106 380 17 symptoms purple 380, 106 63, 7 131, 39 58, 18 95, 27 0.114 0.11 0.3 0.522 1.12 0.893 1.37 0.893 0.432 0.0387 1.413 2.44 1.09 6.15 0.856 0.481 0.075 1.125 2.35 0.932 6.44 0.806 0.443 0.0688 1.162 2.24 0.969 5.76 PRS_PLINK_1.99526231496888e.08 FALSE 766 Neuralgia, neuritis, and radiculitis NOS Both 218 884 17 symptoms purple 884, 218 134, 18 303, 75 141, 32 219, 60 0.0375 0.0756 0.62 0.208 1.04 0.887 1.19 0.56 0.285 0.0493 1.307 1.75 1.02 3.14 0.499 0.33 0.13 0.885 1.65 0.87 3.2 0.606 0.298 0.042 1.376 1.83 1.04 3.37 PRS_PLINK_1.99526231496888e.08 FALSE 767 Cervicocranial/Cervicobrachial syndrome Both 18 30 17 symptoms purple 30, 18 5, 1 9, 6 5, 3 8, 8 0.189 0.24 0.43 0.366 1.21 0.849 2.77 0.495 1.58 0.755 0.122 1.64 0.12 53 1.24 1.85 0.503 0.299 3.46 0.194 806000 0.0982 1.35 0.942 0.026 1.1 0.114 15.8 PRS_PLINK_1.99526231496888e.08 TRUE 769 Nonallopathic lesions NEC Both 90 311 17 symptoms purple 311, 90 52, 9 74, 21 79, 21 76, 31 0.083 0.112 0.459 0.339 1.09 0.864 1.33 0.457 0.453 0.312 0.505 1.58 0.669 3.98 0.364 0.434 0.401 0.397 1.44 0.631 3.49 0.632 0.419 0.132 0.88 1.88 0.854 4.44 PRS_PLINK_1.99526231496888e.08 FALSE 770 Myalgia and myositis unspecified Both 358 848 17 symptoms purple 848, 358 126, 48 273, 127 148, 59 211, 83 -0.012 0.0656 0.855 0.068 0.988 0.865 1.12 0.164 0.208 0.43 0.367 1.18 0.789 1.78 0.0336 0.247 0.892 0.05 1.03 0.64 1.68 -0.0501 0.222 0.821 0.086 0.951 0.618 1.47 PRS_PLINK_1.99526231496888e.08 FALSE 771 Musculoskeletal symptoms referable to limbs Both 193 820 17 symptoms purple 820, 193 115, 22 270, 69 141, 31 203, 54 0.0838 0.0774 0.279 0.555 1.09 0.929 1.26 0.257 0.28 0.358 0.446 1.29 0.757 2.28 0.0648 0.31 0.835 0.079 1.07 0.582 1.98 0.315 0.282 0.263 0.58 1.37 0.798 2.42 PRS_PLINK_1.99526231496888e.08 FALSE 771.1 Swelling of limb Both 269 807 17 symptoms purple 807, 269 116, 39 258, 93 143, 40 200, 71 -0.0229 0.0771 0.766 0.116 0.977 0.833 1.13 0.0631 0.229 0.783 0.106 1.07 0.685 1.68 -0.148 0.268 0.581 0.236 0.862 0.511 1.46 0.0222 0.241 0.927 0.033 1.02 0.641 1.64 PRS_PLINK_1.99526231496888e.08 FALSE 771.2 Cramp of limb Both 61 225 17 symptoms purple 225, 61 36, 9 66, 24 46, 8 56, 17 0.145 0.127 0.253 0.598 1.16 0.885 1.45 0.128 0.457 0.78 0.108 1.14 0.477 2.83 -1.31 0.654 0.0448 1.349 0.269 0.0688 0.911 0.0251 0.501 0.96 0.018 1.03 0.39 2.79 PRS_PLINK_1.99526231496888e.08 FALSE 772 Symptoms of the muscles Both 147 509 17 symptoms purple 509, 147 81, 13 164, 48 89, 26 127, 37 0.00116 0.0956 0.99 0.004 1 0.817 1.19 0.557 0.349 0.11 0.958 1.75 0.9 3.57 0.645 0.388 0.0959 1.018 1.91 0.903 4.19 0.414 0.359 0.249 0.604 1.51 0.759 3.15 PRS_PLINK_1.99526231496888e.08 FALSE 772.1 Muscular wasting and disuse atrophy Both 10 91 17 symptoms purple 91, 10 11, 2 31, 3 14, 0 23, 5 0.422 0.276 0.126 0.9 1.53 0.8 2.66 -1.39 1.11 0.213 0.672 0.249 0.0166 2.47 -1.52 1.25 0.226 0.646 0.219 7.44e-07 2.27 -2.06 1.49 0.166 0.779 0.127 4.14e-06 2.1 PRS_PLINK_1.99526231496888e.08 TRUE 772.2 Spasm of muscle Both 156 662 17 symptoms purple 662, 156 97, 19 225, 51 107, 24 164, 43 0.127 0.0817 0.121 0.918 1.14 0.964 1.32 0.138 0.301 0.648 0.188 1.15 0.646 2.11 0.0488 0.346 0.888 0.052 1.05 0.532 2.08 0.282 0.308 0.359 0.445 1.33 0.734 2.46 PRS_PLINK_1.99526231496888e.08 FALSE 772.3 Muscle weakness Both 85 527 17 symptoms purple 527, 85 83, 9 177, 32 86, 13 131, 26 0.14 0.141 0.32 0.495 1.15 0.87 1.51 0.447 0.41 0.275 0.56 1.56 0.721 3.72 0.343 0.455 0.451 0.346 1.41 0.576 3.58 0.42 0.411 0.307 0.513 1.52 0.695 3.57 PRS_PLINK_1.99526231496888e.08 FALSE 772.4 Rhabdomyolysis Both 7 23 17 symptoms purple 23, 7 7, 1 5, 2 5, 1 6, 3 0.0447 0.213 0.834 0.079 1.05 0.615 1.45 0.69 2.01 0.731 0.136 1.99 0.00453 386 1.15 1.99 0.563 0.249 3.16 0.0597 290 1.05 1.58 0.504 0.297 2.86 0.178 63 PRS_PLINK_1.99526231496888e.08 TRUE 772.6 Facial weakness Both 16 97 17 symptoms purple 97, 16 18, 6 28, 3 20, 4 24, 1 -0.735 0.411 0.0736 1.133 0.479 0.197 1.07 -0.117 0.897 0.896 0.047 0.89 0.151 7.94 0.507 1.02 0.619 0.208 1.66 0.215 24.2 -1.38 0.934 0.139 0.859 0.251 0.0231 1.49 PRS_PLINK_1.99526231496888e.08 TRUE 780 Hypothermia/Chills Both 29 131 17 symptoms purple 131, 29 17, 3 39, 8 26, 3 33, 13 0.312 0.201 0.121 0.916 1.37 0.968 2.16 0.596 0.851 0.484 0.315 1.82 0.359 12.7 -1.39 1.01 0.171 0.766 0.25 0.0181 1.88 0.456 0.68 0.502 0.299 1.58 0.468 6.39 PRS_PLINK_1.99526231496888e.08 TRUE 781 Symptoms involving nervous and musculoskeletal systems Both 100 581 17 symptoms purple 581, 100 88, 21 193, 27 94, 17 144, 23 0.0435 0.0959 0.65 0.187 1.04 0.844 1.24 -0.493 0.322 0.126 0.9 0.611 0.326 1.16 -0.444 0.371 0.232 0.635 0.642 0.306 1.32 -0.408 0.338 0.226 0.645 0.665 0.343 1.29 PRS_PLINK_1.99526231496888e.08 FALSE 781.1 Loss of height Both 1 21 17 symptoms purple 21, 1 4, 0 8, 1 2, 0 5, 0 -0.218 0.889 0.806 0.094 0.804 0.062 5.78 -0.125 2.87 0.965 0.015 0.882 0.0047 120 PRS_PLINK_1.99526231496888e.08 TRUE 781.2 Abnormal posture Both 2 14 17 symptoms purple 14, 2 -0.156 1.24 0.9 0.046 0.856 0.00638 25.9 PRS_PLINK_1.99526231496888e.08 TRUE 782.3 Edema Both 262 843 17 symptoms purple 843, 262 127, 44 286, 81 131, 32 211, 80 0.000618 0.0753 0.993 0.003 1 0.858 1.15 -0.196 0.222 0.378 0.423 0.822 0.536 1.27 -0.36 0.267 0.177 0.752 0.698 0.412 1.17 0.02 0.225 0.929 0.032 1.02 0.66 1.59 PRS_PLINK_1.99526231496888e.08 FALSE 782.6 Pallor and flushing Both 93 323 17 symptoms purple 323, 93 52, 16 79, 16 81, 18 80, 28 0.0503 0.0995 0.614 0.212 1.05 0.849 1.26 -0.534 0.413 0.196 0.707 0.586 0.26 1.31 -0.393 0.399 0.325 0.489 0.675 0.309 1.47 0.281 0.373 0.452 0.345 1.32 0.647 2.78 PRS_PLINK_1.99526231496888e.08 FALSE 783 Fever of unknown origin Both 273 992 17 symptoms purple 992, 273 150, 46 320, 90 172, 45 246, 63 0.0111 0.0679 0.871 0.06 1.01 0.879 1.15 -0.0698 0.211 0.741 0.13 0.933 0.619 1.42 -0.175 0.241 0.468 0.33 0.839 0.523 1.35 -0.172 0.223 0.442 0.355 0.842 0.545 1.31 PRS_PLINK_1.99526231496888e.08 FALSE 783.1 Postprocedural fever Both 11 77 17 symptoms purple 77, 11 12, 1 23, 4 15, 2 19, 1 -0.8 0.476 0.0929 1.032 0.449 0.121 1.14 -0.262 1.31 0.841 0.075 0.769 0.0184 13.2 -0.316 1.29 0.807 0.093 0.729 0.0155 9.77 -0.327 1.26 0.794 0.1 0.721 0.0461 11.7 PRS_PLINK_1.99526231496888e.08 TRUE 785 Abdominal pain Both 830 439 17 symptoms purple 439, 830 67, 104 137, 298 82, 138 110, 199 -0.0304 0.0585 0.604 0.219 0.97 0.867 1.09 0.294 0.192 0.126 0.899 1.34 0.922 1.95 0.0678 0.215 0.753 0.123 1.07 0.705 1.62 0.0774 0.203 0.703 0.153 1.08 0.728 1.6 PRS_PLINK_1.99526231496888e.08 FALSE 788 Syncope and collapse Both 186 911 17 symptoms purple 911, 186 143, 24 307, 66 146, 27 225, 41 -0.179 0.0982 0.0681 1.167 0.836 0.683 1.01 0.108 0.262 0.68 0.167 1.11 0.672 1.89 0.0657 0.305 0.829 0.081 1.07 0.585 1.96 0.00503 0.28 0.986 0.006 1.01 0.582 1.76 PRS_PLINK_1.99526231496888e.08 FALSE 789 Nausea and vomiting Both 486 782 17 symptoms purple 782, 486 116, 58 264, 168 128, 70 194, 136 0.11 0.0589 0.0608 1.216 1.12 0.998 1.26 0.272 0.194 0.16 0.797 1.31 0.904 1.92 0.147 0.227 0.517 0.286 1.16 0.746 1.8 0.384 0.202 0.0571 1.243 1.47 0.995 2.18 PRS_PLINK_1.99526231496888e.08 FALSE 789.1 Persistent vomiting Both 37 250 17 symptoms purple 250, 37 37, 7 89, 12 35, 3 62, 11 0.0167 0.211 0.937 0.028 1.02 0.665 1.53 -0.334 0.521 0.522 0.282 0.716 0.259 2.09 -0.574 0.655 0.381 0.419 0.563 0.137 1.99 -0.0696 0.534 0.896 0.048 0.933 0.334 2.74 PRS_PLINK_1.99526231496888e.08 TRUE 790 Nonspecific findings on examination of blood Both 109 420 17 symptoms purple 420, 109 60, 12 157, 37 54, 12 104, 42 0.262 0.104 0.0118 1.928 1.3 1.08 1.62 0.171 0.385 0.657 0.182 1.19 0.572 2.61 0.177 0.446 0.692 0.16 1.19 0.497 2.89 0.686 0.37 0.0637 1.196 1.98 0.992 4.2 PRS_PLINK_1.99526231496888e.08 FALSE 790.1 Elevated sedimentation rate Both 12 67 17 symptoms purple 67, 12 10, 1 25, 5 8, 1 17, 3 -0.0434 0.424 0.918 0.037 0.958 0.389 2.18 0.142 1.01 0.889 0.051 1.15 0.182 11.4 -0.174 1.71 0.919 0.037 0.84 0.000931 83 0.281 1.23 0.819 0.087 1.32 0.0998 19.9 PRS_PLINK_1.99526231496888e.08 TRUE 790.6 Other abnormal blood chemistry Both 378 844 17 symptoms purple 844, 378 120, 47 293, 122 130, 55 210, 115 0.0927 0.0616 0.132 0.879 1.1 0.973 1.24 0.00331 0.215 0.988 0.005 1 0.663 1.53 0.0674 0.251 0.788 0.103 1.07 0.658 1.74 0.325 0.217 0.134 0.874 1.38 0.912 2.12 PRS_PLINK_1.99526231496888e.08 FALSE 790.8 Elevated C-reactive protein (CRP) Both 17 89 17 symptoms purple 89, 17 11, 2 28, 7 16, 2 22, 4 0.323 0.383 0.399 0.399 1.38 0.666 2.99 0.701 1.2 0.56 0.252 2.02 0.251 25.5 -0.467 1.37 0.733 0.135 0.627 0.0253 12.6 0.251 1.47 0.864 0.064 1.29 4.29e-06 703 PRS_PLINK_1.99526231496888e.08 TRUE 790.9 Abnormal arterial blood gases Both 6 21 17 symptoms purple 21, 6 4, 0 6, 0 4, 4 5, 1 0.0493 0.779 0.949 0.023 1.05 0.28 4.12 0.0162 483 1 0 1.02 0.743 1.3 -0.0127 789 1 0 0.987 0.00282 1.26 PRS_PLINK_1.99526231496888e.08 TRUE 791 Gangrene Both 5 60 17 symptoms purple 60, 5 7, 2 19, 1 12, 1 14, 0 -0.012 0.389 0.975 0.011 0.988 0.238 1.87 -1.02 1.15 0.374 0.427 0.361 0.0019 2.71 -0.548 1.24 0.66 0.181 0.578 0.0519 5.24 -1.75 1.5 0.241 0.618 0.173 6.01e-09 2 PRS_PLINK_1.99526231496888e.08 TRUE 792 Abnormal Papanicolaou smear of cervix and cervical HPV Female 261 369 11 genitourinary black 369, 261 49, 25 125, 95 60, 34 91, 77 0.0796 0.0847 0.347 0.459 1.08 0.918 1.27 0.448 0.294 0.128 0.892 1.57 0.893 2.8 0.0891 0.337 0.792 0.101 1.09 0.572 2.1 0.445 0.301 0.14 0.854 1.56 0.879 2.82 PRS_PLINK_1.99526231496888e.08 FALSE 792.1 Papanicolaou smear of cervix or vagina with atypical squamous cells Female 112 295 11 genitourinary black 295, 112 40, 12 95, 37 51, 15 74, 31 0.0245 0.112 0.827 0.082 1.02 0.81 1.26 0.383 0.418 0.359 0.444 1.47 0.669 3.41 -0.0531 0.463 0.909 0.042 0.948 0.388 2.34 0.221 0.414 0.593 0.227 1.25 0.568 2.84 PRS_PLINK_1.99526231496888e.08 FALSE 794 Abnormal results of other function studies (bladder, pancreas, placenta, spleen, etc) Both 12 108 17 symptoms purple 108, 12 16, 3 35, 4 19, 0 27, 5 0.265 0.185 0.151 0.821 1.3 0.998 2.47 -0.693 0.865 0.423 0.374 0.5 0.0838 2.86 -2.4 1.39 0.0842 1.075 0.0905 9.45e-05 0.99 -0.188 0.84 0.823 0.085 0.828 0.159 4.36 PRS_PLINK_1.99526231496888e.08 TRUE 795 Other and nonspecific abnormal cytological, histological and immunological findings Both 161 801 17 symptoms purple 801, 161 112, 11 276, 56 126, 20 198, 54 0.124 0.0818 0.13 0.887 1.13 0.963 1.32 0.78 0.349 0.0256 1.592 2.18 1.13 4.56 0.506 0.382 0.186 0.731 1.66 0.78 3.69 1 0.345 0.00369 2.433 2.72 1.42 5.65 PRS_PLINK_1.99526231496888e.08 FALSE 795.8 Abnormal tumor markers Both 45 175 17 symptoms purple 175, 45 25, 6 61, 12 25, 6 43, 14 0.158 0.228 0.488 0.312 1.17 0.753 1.85 -0.519 0.584 0.374 0.427 0.595 0.192 1.91 0.0791 0.69 0.909 0.042 1.08 0.288 4.28 0.349 0.563 0.536 0.271 1.42 0.498 4.37 PRS_PLINK_1.99526231496888e.08 TRUE 795.81 Elevated carcinoembryonic antigen [CEA] Both 1 8 17 symptoms purple 8, 1 1, 0 2, 0 3, 0 1, 0 0.0511 29.8 0.999 0.001 1.05 0.914 8460 PRS_PLINK_1.99526231496888e.08 TRUE 795.82 Elevated cancer antigen 125 [CA 125] Both 8 47 17 symptoms purple 47, 8 3, 0 17, 4 6, 0 12, 3 0.281 0.508 0.58 0.236 1.32 0.484 3.78 -0.0606 2.15 0.978 0.01 0.941 0.0177 242 1.89 2.44 0.439 0.358 6.62 0.243 15600 PRS_PLINK_1.99526231496888e.08 TRUE 796 Elevated prostate specific antigen [PSA] Male 41 64 11 genitourinary black 64, 41 12, 8 19, 11 14, 9 15, 6 -0.369 0.31 0.235 0.629 0.692 0.375 1.24 -0.361 0.691 0.601 0.221 0.697 0.184 2.47 0.0293 0.835 0.972 0.012 1.03 0.222 4.98 -1.66 1.13 0.14 0.853 0.19 0.0103 1.3 PRS_PLINK_1.99526231496888e.08 TRUE 797 Shock Both 11 96 17 symptoms purple 96, 11 15, 1 26, 2 22, 4 24, 3 0.212 0.384 0.58 0.237 1.24 0.569 2.82 0.425 1.18 0.718 0.144 1.53 0.119 237 0.927 1.23 0.451 0.346 2.53 0.22 177 0.576 0.97 0.553 0.257 1.78 0.24 27.8 PRS_PLINK_1.99526231496888e.08 TRUE 797.1 Cardiogenic shock Both 2 37 17 symptoms purple 37, 2 5, 0 9, 1 9, 0 9, 1 0.179 0.798 0.823 0.085 1.2 0.174 14.1 1.25 2.01 0.535 0.272 3.49 0.11 391 -0.112 3.18 0.972 0.012 0.894 0.00289 465 PRS_PLINK_1.99526231496888e.08 TRUE 798 Malaise and fatigue Both 686 583 17 symptoms purple 583, 686 91, 105 190, 220 97, 116 146, 170 -0.0622 0.0589 0.291 0.537 0.94 0.835 1.05 -0.0575 0.183 0.753 0.123 0.944 0.661 1.35 -0.028 0.209 0.894 0.049 0.972 0.648 1.46 -0.0511 0.191 0.789 0.103 0.95 0.655 1.38 PRS_PLINK_1.99526231496888e.08 FALSE 798.1 Chronic fatigue syndrome Both 138 347 17 symptoms purple 347, 138 51, 13 124, 53 50, 23 86, 35 0.0879 0.102 0.388 0.411 1.09 0.893 1.32 0.392 0.356 0.271 0.567 1.48 0.757 3.03 0.438 0.418 0.295 0.53 1.55 0.698 3.54 0.334 0.386 0.386 0.413 1.4 0.67 3.01 PRS_PLINK_1.99526231496888e.08 FALSE 800 Fracture of lower limb Both 92 514 18 injuries & poisonings gray50 514, 92 70, 15 152, 32 103, 18 129, 18 -0.15 0.134 0.263 0.579 0.861 0.651 1.11 -0.0442 0.352 0.9 0.046 0.957 0.487 1.94 -0.109 0.388 0.778 0.109 0.896 0.419 1.95 -0.285 0.387 0.461 0.336 0.752 0.352 1.64 PRS_PLINK_1.99526231496888e.08 FALSE 800.1 Fracture of neck of femur Both 20 85 18 injuries & poisonings gray50 85, 20 10, 0 25, 10 17, 3 21, 5 -0.0989 0.236 0.675 0.17 0.906 0.495 1.32 2.17 1.59 0.172 0.764 8.73 0.664 1310 1.99 2.11 0.345 0.462 7.31 0.192 54700000 1.28 1.47 0.385 0.415 3.58 0.331 1660 PRS_PLINK_1.99526231496888e.08 TRUE 800.2 Fracture of unspecified part of femur Both 21 105 18 injuries & poisonings gray50 105, 21 12, 1 26, 7 26, 8 26, 4 -0.0303 0.222 0.891 0.05 0.97 0.562 1.4 1.17 1.12 0.299 0.525 3.21 0.436 48.1 0.621 1.11 0.577 0.239 1.86 0.242 37.4 0.164 1.07 0.878 0.057 1.18 0.178 13.3 PRS_PLINK_1.99526231496888e.08 TRUE 800.3 Fracture of tibia and fibula Both 35 189 18 injuries & poisonings gray50 189, 35 30, 9 58, 11 36, 8 47, 6 -0.0537 0.243 0.825 0.083 0.948 0.587 1.54 -0.519 0.53 0.327 0.485 0.595 0.213 1.68 -0.379 0.581 0.514 0.289 0.684 0.218 2.07 -1.01 0.609 0.0972 1.012 0.364 0.103 1.17 PRS_PLINK_1.99526231496888e.08 TRUE 800.4 Fracture of patella Both 17 83 18 injuries & poisonings gray50 83, 17 11, 4 22, 3 19, 2 21, 6 0.174 0.17 0.307 0.514 1.19 0.836 1.59 0.814 1.18 0.492 0.308 2.26 0.282 37.5 0.194 1.34 0.885 0.053 1.21 0.0754 25 0.778 0.931 0.403 0.395 2.18 0.428 13.5 PRS_PLINK_1.99526231496888e.08 TRUE 801 Fracture of ankle and foot Both 125 626 18 injuries & poisonings gray50 626, 125 83, 18 201, 45 112, 20 156, 33 5e-04 0.0986 0.996 0.002 1 0.806 1.19 -0.0334 0.326 0.918 0.037 0.967 0.519 1.86 -0.223 0.368 0.545 0.263 0.8 0.387 1.66 0.00069 0.326 0.998 0.001 1 0.532 1.93 PRS_PLINK_1.99526231496888e.08 FALSE 801.1 Fracture of foot Both 53 290 18 injuries & poisonings gray50 290, 53 41, 11 85, 13 58, 10 73, 14 -0.0756 0.183 0.68 0.167 0.927 0.625 1.3 -0.588 0.481 0.221 0.655 0.555 0.216 1.43 -0.409 0.505 0.418 0.379 0.664 0.237 1.82 -0.259 0.461 0.574 0.241 0.772 0.316 1.93 PRS_PLINK_1.99526231496888e.08 FALSE 802 Fracture of pelvis Both 10 78 18 injuries & poisonings gray50 78, 10 7, 0 19, 3 19, 3 20, 3 0.116 0.38 0.76 0.119 1.12 0.526 2.45 -0.463 1.64 0.778 0.109 0.629 0.015 52.4 1.74 1.89 0.359 0.444 5.67 0.216 1660 1.08 1.68 0.519 0.285 2.95 0.0916 980 PRS_PLINK_1.99526231496888e.08 TRUE 803 Fracture of upper limb Both 81 487 18 injuries & poisonings gray50 487, 81 66, 11 156, 38 85, 8 122, 18 -0.0387 0.128 0.762 0.118 0.962 0.725 1.21 0.208 0.384 0.588 0.231 1.23 0.593 2.71 -0.469 0.479 0.328 0.484 0.626 0.233 1.63 -0.196 0.41 0.632 0.199 0.822 0.368 1.89 PRS_PLINK_1.99526231496888e.08 FALSE 803.1 Fracture of humerus Both 28 144 18 injuries & poisonings gray50 144, 28 15, 3 50, 15 22, 1 36, 7 -0.00538 0.192 0.978 0.01 0.995 0.642 1.39 0.226 0.69 0.744 0.129 1.25 0.354 5.45 -0.867 0.956 0.364 0.438 0.42 0.0377 4.2 0.206 0.75 0.783 0.106 1.23 0.32 6.12 PRS_PLINK_1.99526231496888e.08 TRUE 803.2 Fracture of radius and ulna Both 56 281 18 injuries & poisonings gray50 281, 56 37, 5 88, 29 52, 7 70, 11 0.0363 0.146 0.803 0.095 1.04 0.736 1.34 0.785 0.541 0.146 0.834 2.19 0.809 7.04 0.102 0.628 0.871 0.06 1.11 0.315 4.08 0.334 0.599 0.577 0.239 1.4 0.439 4.94 PRS_PLINK_1.99526231496888e.08 FALSE 803.21 Colles' fracture Both 17 57 18 injuries & poisonings gray50 57, 17 7, 3 16, 8 12, 2 14, 2 -0.258 0.37 0.486 0.313 0.773 0.303 1.38 0.656 1.05 0.531 0.275 1.93 0.323 15.3 -0.647 1.22 0.596 0.224 0.523 0.0263 8.12 -0.26 1.11 0.815 0.089 0.771 0.0609 6.67 PRS_PLINK_1.99526231496888e.08 TRUE 803.3 Fracture of clavicle or scapula Both 15 94 18 injuries & poisonings gray50 94, 15 15, 2 28, 7 18, 1 24, 4 0.0347 0.333 0.917 0.038 1.04 0.456 1.84 0.134 0.946 0.888 0.052 1.14 0.196 11.5 -0.19 1.02 0.853 0.069 0.827 0.0973 7.41 -0.467 1.07 0.661 0.18 0.627 0.0353 5.85 PRS_PLINK_1.99526231496888e.08 TRUE 804 Fracture of hand or wrist Both 74 395 18 injuries & poisonings gray50 395, 74 45, 9 118, 34 76, 12 99, 17 -0.0155 0.151 0.918 0.037 0.985 0.725 1.31 0.341 0.442 0.441 0.356 1.41 0.612 3.48 -0.303 0.512 0.554 0.256 0.739 0.269 2.04 -0.105 0.469 0.822 0.085 0.9 0.364 2.32 PRS_PLINK_1.99526231496888e.08 FALSE 805 Fracture of vertebral column without mention of spinal cord injury Both 50 222 18 injuries & poisonings gray50 222, 50 35, 2 71, 22 39, 6 56, 16 0.0594 0.16 0.71 0.149 1.06 0.749 1.41 1.43 0.678 0.0355 1.45 4.16 1.23 21.6 0.647 0.769 0.4 0.398 1.91 0.43 12.4 1.37 0.729 0.0611 1.214 3.92 1.03 22.9 PRS_PLINK_1.99526231496888e.08 TRUE 807 Fracture of ribs Both 24 103 18 injuries & poisonings gray50 103, 24 15, 1 32, 11 19, 5 26, 5 -0.397 0.317 0.21 0.677 0.673 0.351 1.22 0.889 0.983 0.366 0.437 2.43 0.432 25.8 0.658 1.03 0.524 0.28 1.93 0.286 22.6 0.342 1.02 0.737 0.133 1.41 0.211 17.3 PRS_PLINK_1.99526231496888e.08 TRUE 809 Fracture of unspecified bones Both 111 718 18 injuries & poisonings gray50 718, 111 93, 18 236, 46 123, 16 177, 20 -0.00529 0.0992 0.957 0.019 0.995 0.798 1.19 -0.0388 0.311 0.901 0.045 0.962 0.531 1.8 -0.553 0.383 0.149 0.828 0.575 0.268 1.21 -0.494 0.348 0.155 0.809 0.61 0.307 1.22 PRS_PLINK_1.99526231496888e.08 FALSE 816 Cerebral laceration and contusion Both 3 3 18 injuries & poisonings gray50 3, 3 0.652 916 0.999 0 1.92 0.378 9.84 PRS_PLINK_1.99526231496888e.08 TRUE 817 Concussion Both 57 315 18 injuries & poisonings gray50 315, 57 43, 2 106, 29 50, 8 79, 13 0.174 0.155 0.261 0.584 1.19 0.898 1.65 1.6 0.721 0.0266 1.576 4.95 1.36 27.9 0.955 0.715 0.182 0.741 2.6 0.646 14.6 0.77 0.695 0.268 0.571 2.16 0.571 11.8 PRS_PLINK_1.99526231496888e.08 FALSE 818 Intracranial hemorrhage (injury) Both 5 49 18 injuries & poisonings gray50 49, 5 8, 1 13, 3 11, 1 12, 0 -0.215 0.559 0.7 0.155 0.806 0.241 2.73 -0.314 1.28 0.805 0.094 0.73 0.022 8.06 -0.12 1.67 0.942 0.026 0.887 0.000792 692 -0.989 1.51 0.512 0.291 0.372 0.00548 15.1 PRS_PLINK_1.99526231496888e.08 TRUE 818.1 Subdural hemorrhage (injury) Both 1 12 18 injuries & poisonings gray50 12, 1 1, 0 3, 1 3, 0 3, 0 0.0207 1.25 0.987 0.006 1.02 0.0959 31.3 -3.01e-05 8410 1 0 1 0.304 3.14 PRS_PLINK_1.99526231496888e.08 TRUE 818.2 Subarachnoid hemorrhage (injury) Both 3 30 18 injuries & poisonings gray50 30, 3 6, 1 9, 1 4, 1 8, 0 -0.404 0.817 0.621 0.207 0.668 0.11 3.93 1.43 2.35 0.542 0.266 4.19 0.132 1.8e+08 0.669 2.87 0.816 0.088 1.95 0.000117 38300 -0.304 2.32 0.896 0.048 0.738 0.00409 475 PRS_PLINK_1.99526231496888e.08 TRUE 819 Skull and face fracture and other intercranial injury Both 89 598 18 injuries & poisonings gray50 598, 89 78, 5 198, 45 96, 10 150, 22 0.1 0.105 0.338 0.471 1.11 0.888 1.34 1.12 0.468 0.017 1.768 3.06 1.29 8.73 0.454 0.551 0.41 0.387 1.57 0.518 5.26 0.627 0.476 0.187 0.727 1.87 0.75 5.49 PRS_PLINK_1.99526231496888e.08 FALSE 830 Dislocation Both 179 901 18 injuries & poisonings gray50 901, 179 133, 17 293, 70 157, 31 225, 35 0.0433 0.0809 0.593 0.227 1.04 0.88 1.21 0.523 0.29 0.0716 1.145 1.69 0.971 3.07 0.288 0.325 0.375 0.426 1.33 0.708 2.58 0.0811 0.311 0.795 0.1 1.08 0.591 2.05 PRS_PLINK_1.99526231496888e.08 FALSE 835 Internal derangement of knee Both 109 538 18 injuries & poisonings gray50 538, 109 89, 12 172, 42 91, 18 135, 22 -0.0363 0.112 0.747 0.127 0.964 0.753 1.18 0.358 0.359 0.318 0.497 1.43 0.72 3 0.349 0.422 0.408 0.39 1.42 0.619 3.33 0.122 0.388 0.753 0.123 1.13 0.527 2.51 PRS_PLINK_1.99526231496888e.08 FALSE 836 Traumatic arthropathy Both 16 72 18 injuries & poisonings gray50 72, 16 13, 3 18, 2 19, 7 17, 4 0.41 0.422 0.331 0.48 1.51 0.677 3.6 -0.744 1.01 0.462 0.335 0.475 0.0494 3.42 0.788 0.823 0.338 0.471 2.2 0.508 11.6 -0.297 1 0.767 0.115 0.743 0.0999 5.52 PRS_PLINK_1.99526231496888e.08 TRUE 840 Sprains and strains Both 421 798 18 injuries & poisonings gray50 798, 421 122, 43 266, 151 132, 66 197, 115 0.0673 0.062 0.278 0.556 1.07 0.947 1.2 0.415 0.212 0.0502 1.299 1.51 1.01 2.3 0.275 0.243 0.257 0.59 1.32 0.824 2.12 0.412 0.221 0.0625 1.204 1.51 0.987 2.33 PRS_PLINK_1.99526231496888e.08 FALSE 840.1 Muscle/tendon sprain Both 28 61 18 injuries & poisonings gray50 61, 28 10, 4 19, 10 11, 3 15, 7 0.0163 0.187 0.931 0.031 1.02 0.677 1.4 0.131 0.816 0.873 0.059 1.14 0.261 5.54 -0.56 1.14 0.624 0.205 0.571 0.0625 4.44 0.0607 0.992 0.951 0.022 1.06 0.177 7.29 PRS_PLINK_1.99526231496888e.08 TRUE 840.2 Rotator cuff (capsule) sprain Both 74 216 18 injuries & poisonings gray50 216, 74 30, 4 53, 22 54, 17 54, 20 -0.056 0.184 0.761 0.118 0.946 0.661 1.35 0.994 0.62 0.109 0.963 2.7 0.869 10.4 0.686 0.58 0.237 0.626 1.99 0.681 6.92 0.903 0.588 0.125 0.904 2.47 0.841 8.9 PRS_PLINK_1.99526231496888e.08 FALSE 840.3 Joint/ligament sprain Both 142 650 18 injuries & poisonings gray50 650, 142 97, 16 221, 48 106, 19 160, 41 0.104 0.0869 0.232 0.635 1.11 0.926 1.3 0.147 0.323 0.649 0.188 1.16 0.624 2.23 -0.0487 0.385 0.899 0.046 0.952 0.444 2.05 0.459 0.328 0.162 0.791 1.58 0.845 3.08 PRS_PLINK_1.99526231496888e.08 FALSE 841 Sprains and strains of back and neck Both 109 403 18 injuries & poisonings gray50 403, 109 61, 10 138, 37 63, 24 101, 23 -0.122 0.132 0.354 0.451 0.885 0.666 1.13 0.191 0.396 0.629 0.201 1.21 0.57 2.73 0.724 0.447 0.106 0.975 2.06 0.888 5.06 0.106 0.42 0.8 0.097 1.11 0.492 2.63 PRS_PLINK_1.99526231496888e.08 FALSE 842 Other sprains and strains Both 78 342 18 injuries & poisonings gray50 342, 78 52, 10 113, 34 55, 9 86, 15 -0.0471 0.131 0.719 0.143 0.954 0.702 1.19 0.391 0.401 0.329 0.483 1.48 0.693 3.37 -0.374 0.516 0.469 0.329 0.688 0.243 1.89 -0.12 0.477 0.801 0.096 0.887 0.345 2.32 PRS_PLINK_1.99526231496888e.08 FALSE 850 Hemorrhage or hematoma complicating a procedure Both 60 499 18 injuries & poisonings gray50 499, 60 70, 7 172, 16 78, 7 124, 19 -0.00306 0.159 0.985 0.007 0.997 0.714 1.35 -0.0917 0.457 0.841 0.075 0.912 0.373 2.42 -0.166 0.527 0.753 0.123 0.847 0.283 2.53 0.375 0.456 0.411 0.387 1.46 0.607 3.82 PRS_PLINK_1.99526231496888e.08 FALSE 851 Complications of transplants and reattached limbs Both 64 591 18 injuries & poisonings gray50 591, 64 81, 6 208, 23 89, 12 146, 16 -0.0361 0.16 0.821 0.085 0.965 0.695 1.31 0.523 0.468 0.263 0.579 1.69 0.695 4.71 0.573 0.489 0.241 0.618 1.77 0.677 5.09 0.209 0.474 0.659 0.181 1.23 0.489 3.44 PRS_PLINK_1.99526231496888e.08 FALSE 853 Complication of colostomy or enterostomy Both 12 102 18 injuries & poisonings gray50 102, 12 10, 2 29, 3 21, 3 26, 2 -0.518 0.364 0.155 0.811 0.596 0.282 1.22 -0.15 1.11 0.892 0.05 0.86 0.108 13.5 0.283 1.11 0.8 0.097 1.33 0.153 12.9 -1.33 1.2 0.267 0.574 0.265 0.00718 2.52 PRS_PLINK_1.99526231496888e.08 TRUE 854 Complications of cardiac/vascular device, implant, and graft Both 58 418 18 injuries & poisonings gray50 418, 58 62, 7 153, 20 52, 10 105, 17 0.272 0.152 0.0731 1.136 1.31 0.986 1.78 0.185 0.451 0.682 0.166 1.2 0.509 3.13 0.582 0.525 0.268 0.573 1.79 0.645 5.23 0.366 0.473 0.438 0.358 1.44 0.581 3.89 PRS_PLINK_1.99526231496888e.08 FALSE 855 Complication of nervous system device, implant, and graft Both 2 69 18 injuries & poisonings gray50 69, 2 9, 0 24, 0 10, 1 17, 0 -0.798 0.865 0.356 0.448 0.45 0.00134 3.12 0.67 1.71 0.696 0.157 1.95 0.0117 944 PRS_PLINK_1.99526231496888e.08 TRUE 856 Vascular complications of surgery and medical procedures Both 7 64 18 injuries & poisonings gray50 64, 7 13, 3 19, 1 12, 1 16, 1 -1.02 0.566 0.0724 1.14 0.362 0.0963 1.07 -2.15 1.32 0.103 0.987 0.116 0.000155 1.23 -0.439 1.12 0.695 0.158 0.644 0.0635 5.27 -3.33 2.08 0.11 0.957 0.036 0.0276 1.02 PRS_PLINK_1.99526231496888e.08 TRUE 857 Mechanical complication of unspecified genitourinary device, implant, and graft Both 65 410 18 injuries & poisonings gray50 410, 65 62, 13 130, 19 79, 8 98, 21 -0.00783 0.164 0.962 0.017 0.992 0.708 1.36 -0.67 0.412 0.104 0.983 0.512 0.226 1.16 -0.664 0.473 0.16 0.795 0.515 0.192 1.3 -0.03 0.4 0.94 0.027 0.97 0.443 2.17 PRS_PLINK_1.99526231496888e.08 FALSE 858 Complication of internal orthopedic device Both 55 515 18 injuries & poisonings gray50 515, 55 61, 6 171, 21 85, 8 129, 16 0.202 0.0992 0.0417 1.38 1.22 0.995 1.46 -0.00211 0.482 0.997 0.002 0.998 0.399 2.79 -0.0795 0.576 0.89 0.051 0.924 0.295 3.12 0.0487 0.486 0.92 0.036 1.05 0.412 2.96 PRS_PLINK_1.99526231496888e.08 FALSE 859 Complication due to other implant and internal device Both 64 558 18 injuries & poisonings gray50 558, 64 73, 10 189, 32 88, 6 138, 12 -0.238 0.165 0.15 0.823 0.788 0.561 1.09 0.134 0.387 0.729 0.137 1.14 0.546 2.56 -0.44 0.504 0.383 0.417 0.644 0.219 1.78 -0.426 0.442 0.335 0.475 0.653 0.268 1.62 PRS_PLINK_1.99526231496888e.08 FALSE 860 Bone marrow or stem cell transplant Both 8 38 2 neoplasms darkcyan 38, 8 4, 0 14, 4 4, 1 10, 2 0.477 0.547 0.384 0.416 1.61 0.574 4.95 -0.265 1.84 0.885 0.053 0.767 0.00602 106 -0.404 3.52 0.909 0.042 0.668 0.0014 107 1.51 2.07 0.464 0.333 4.53 0.234 7320 PRS_PLINK_1.99526231496888e.08 TRUE 870 Open wounds of head; neck; and trunk Both 153 835 18 injuries & poisonings gray50 835, 153 122, 23 260, 56 152, 24 209, 28 -0.201 0.107 0.0604 1.219 0.818 0.657 1 -0.0153 0.275 0.956 0.02 0.985 0.58 1.71 -0.188 0.314 0.549 0.261 0.828 0.446 1.54 -0.355 0.301 0.239 0.622 0.701 0.386 1.28 PRS_PLINK_1.99526231496888e.08 FALSE 870.1 Open wound or laceration of eye or eyelid Both 7 45 18 injuries & poisonings gray50 45, 7 8, 1 15, 4 8, 0 10, 1 -0.884 0.628 0.159 0.798 0.413 0.0696 1.33 -0.838 1.33 0.53 0.276 0.432 0.0106 5.39 -1.19 3.93 0.762 0.118 0.304 7.11e-05 600 -0.00227 1.64 0.999 0 0.998 0.0132 489 PRS_PLINK_1.99526231496888e.08 TRUE 870.2 Open wound of ear Both 6 32 18 injuries & poisonings gray50 32, 6 3, 1 9, 2 7, 0 8, 3 0.568 0.67 0.396 0.402 1.77 0.48 10.9 -0.299 1.84 0.871 0.06 0.742 0.0313 14 -1.63 2.12 0.442 0.355 0.196 0.00241 3.77 -1.94 2.5 0.438 0.358 0.144 2.03e-06 4.63 PRS_PLINK_1.99526231496888e.08 TRUE 870.3 Other open wound of head and face Both 41 270 18 injuries & poisonings gray50 270, 41 26, 4 84, 9 50, 11 68, 9 -0.118 0.193 0.543 0.265 0.889 0.585 1.27 -0.711 0.662 0.283 0.549 0.491 0.127 1.96 0.0307 0.67 0.963 0.016 1.03 0.281 4.12 -0.289 0.639 0.652 0.186 0.749 0.21 2.87 PRS_PLINK_1.99526231496888e.08 TRUE 870.4 Open wound of nose and sinus Both 4 47 18 injuries & poisonings gray50 47, 4 9, 2 12, 0 11, 0 12, 0 -0.71 0.702 0.312 0.506 0.492 0.0562 1.83 -0.881 1.94 0.65 0.187 0.414 0.00058 168 -1.15 1.63 0.479 0.319 0.317 0.00114 4.9 -0.322 1.77 0.856 0.068 0.725 0.000929 152 PRS_PLINK_1.99526231496888e.08 TRUE 870.5 Open wound of lip and mouth Both 5 53 18 injuries & poisonings gray50 53, 5 10, 0 14, 1 12, 0 13, 4 1.58 0.818 0.0527 1.278 4.87 1.06 92.7 0.294 1.38 0.831 0.08 1.34 0.0451 108 1.97 1.38 0.153 0.816 7.19 0.712 373 PRS_PLINK_1.99526231496888e.08 TRUE 870.6 Open wound of neck Both 1 34 18 injuries & poisonings gray50 34, 1 2, 0 12, 0 4, 0 9, 1 0.445 0.816 0.586 0.232 1.56 0.135 40 0.633 4.06 0.876 0.057 1.88 0.000112 3160 PRS_PLINK_1.99526231496888e.08 TRUE 870.8 Open wound of genital organs Both 8 57 18 injuries & poisonings gray50 57, 8 7, 2 17, 3 11, 2 14, 0 -0.348 0.454 0.443 0.353 0.706 0.268 1.71 -0.147 1.16 0.899 0.046 0.863 0.0902 7.31 0.323 2.18 0.883 0.054 1.38 0.0162 137 -0.845 1.85 0.648 0.189 0.429 0.000868 10.5 PRS_PLINK_1.99526231496888e.08 TRUE 871 Open wounds of extremities Both 159 716 18 injuries & poisonings gray50 716, 159 109, 32 222, 65 135, 23 176, 28 -0.0339 0.0877 0.699 0.156 0.967 0.8 1.13 -0.0254 0.247 0.918 0.037 0.975 0.606 1.59 -0.487 0.306 0.111 0.953 0.614 0.334 1.12 -0.639 0.288 0.0267 1.573 0.528 0.298 0.93 PRS_PLINK_1.99526231496888e.08 FALSE 871.1 Open wound of hand except finger(s) Both 25 151 18 injuries & poisonings gray50 151, 25 28, 7 41, 10 32, 1 38, 5 -0.125 0.198 0.527 0.278 0.882 0.45 1.18 -0.328 0.559 0.558 0.253 0.721 0.245 2.13 -2.07 0.922 0.0248 1.606 0.126 0.012 0.692 -0.625 0.629 0.321 0.494 0.535 0.148 1.83 PRS_PLINK_1.99526231496888e.08 TRUE 871.2 Open wound of finger(s) Both 55 238 18 injuries & poisonings gray50 238, 55 38, 9 70, 26 47, 5 60, 12 -0.0282 0.153 0.854 0.069 0.972 0.675 1.25 0.372 0.438 0.396 0.403 1.45 0.64 3.5 -0.385 0.607 0.526 0.279 0.681 0.2 2.24 0.0111 0.505 0.983 0.008 1.01 0.381 2.77 PRS_PLINK_1.99526231496888e.08 FALSE 871.3 Open wound of foot except toe(s) alone Both 23 104 18 injuries & poisonings gray50 104, 23 13, 4 26, 8 27, 6 25, 4 -0.0455 0.319 0.887 0.052 0.956 0.51 1.82 -0.526 0.963 0.585 0.233 0.591 0.0821 3.7 -0.243 0.851 0.775 0.111 0.784 0.132 4.59 0.502 1.06 0.636 0.196 1.65 0.182 19.3 PRS_PLINK_1.99526231496888e.08 TRUE 871.4 Open wound of toe(s) Both 15 48 18 injuries & poisonings gray50 48, 15 8, 9 12, 3 12, 0 12, 1 -0.883 0.48 0.0655 1.184 0.413 0.151 1.03 -1.82 0.98 0.0626 1.204 0.161 0.0139 0.815 -3.61 1.71 0.0349 1.457 0.0271 7.19e-05 0.427 -2.46 1.16 0.034 1.468 0.0852 0.0033 0.595 PRS_PLINK_1.99526231496888e.08 TRUE 872 Traumatic amputation Both 5 70 18 injuries & poisonings gray50 70, 5 10, 0 19, 1 15, 1 18, 2 0.0722 0.287 0.801 0.096 1.07 0.484 1.72 0.414 1.66 0.803 0.096 1.51 0.012 239 -0.107 1.55 0.945 0.025 0.899 0.00302 103 0.701 1.52 0.645 0.191 2.02 0.0733 756000 PRS_PLINK_1.99526231496888e.08 TRUE 874 Complication of amputation stump Both 1 23 18 injuries & poisonings gray50 23, 1 4, 0 8, 1 3, 0 6, 0 0.247 0.921 0.788 0.103 1.28 0.156 26.9 -0.549 2.33 0.814 0.09 0.577 0.00346 61.5 PRS_PLINK_1.99526231496888e.08 TRUE 875 Non-healing surgical wound Both 12 133 18 injuries & poisonings gray50 133, 12 20, 1 35, 0 31, 2 33, 6 0.201 0.225 0.372 0.43 1.22 0.487 1.91 -1.18 1.14 0.299 0.524 0.307 0.00373 4.68 0.655 1.06 0.538 0.27 1.93 0.174 36.8 1.09 0.957 0.256 0.592 2.97 0.476 32.6 PRS_PLINK_1.99526231496888e.08 TRUE 876 Posttraumatic wound infection not elsewhere classified Both 28 175 18 injuries & poisonings gray50 175, 28 27, 6 51, 6 34, 5 44, 8 0.11 0.128 0.39 0.409 1.12 0.853 1.4 -0.606 0.63 0.336 0.474 0.546 0.158 1.9 -0.495 0.647 0.445 0.352 0.61 0.163 2.14 -0.246 0.585 0.674 0.171 0.782 0.25 2.52 PRS_PLINK_1.99526231496888e.08 TRUE 907 Injuries to the nervous system Both 41 221 18 injuries & poisonings gray50 221, 41 30, 9 71, 12 40, 9 54, 9 -0.143 0.23 0.534 0.272 0.867 0.552 1.37 -0.726 0.525 0.167 0.779 0.484 0.173 1.34 -0.619 0.56 0.269 0.57 0.538 0.175 1.57 -0.9 0.561 0.109 0.964 0.407 0.132 1.2 PRS_PLINK_1.99526231496888e.08 TRUE 910 Superficial injury, infected Both 7 36 18 injuries & poisonings gray50 36, 7 5, 0 12, 3 6, 0 9, 4 0.291 0.321 0.365 0.438 1.34 0.816 4.92 1.25 1.87 0.504 0.298 3.49 0.108 162000 1.05 1.86 0.574 0.241 2.84 0.0658 36100 PRS_PLINK_1.99526231496888e.08 TRUE 911 Blister Both 17 76 18 injuries & poisonings gray50 76, 17 13, 5 26, 7 12, 1 19, 3 -0.0879 0.214 0.681 0.167 0.916 0.622 1.37 -0.821 0.804 0.307 0.513 0.44 0.0806 2.33 -1.25 1.37 0.363 0.44 0.286 2.74e-05 4.09 -1.76 1.12 0.116 0.934 0.172 0.00654 1.33 PRS_PLINK_1.99526231496888e.08 TRUE 912 Insect bite Both 28 154 18 injuries & poisonings gray50 154, 28 26, 4 43, 6 32, 4 39, 6 -0.411 0.259 0.112 0.951 0.663 0.39 1.1 -0.103 0.663 0.876 0.057 0.902 0.247 3.48 -0.0586 0.723 0.935 0.029 0.943 0.22 4.14 -0.0355 0.748 0.962 0.017 0.965 0.208 4.75 PRS_PLINK_1.99526231496888e.08 TRUE 913 Toxic effect of venom Both 13 98 18 injuries & poisonings gray50 98, 13 13, 1 38, 5 10, 3 25, 1 -0.378 0.38 0.32 0.495 0.685 0.309 1.45 -0.278 0.953 0.771 0.113 0.758 0.105 7.76 -0.95 1.63 0.56 0.252 0.387 0.0022 10.5 -0.495 1.05 0.639 0.195 0.609 0.00178 7.55 PRS_PLINK_1.99526231496888e.08 TRUE 916 Contusion Both 230 945 18 injuries & poisonings gray50 945, 230 131, 27 303, 98 165, 40 235, 51 0.0131 0.0753 0.862 0.065 1.01 0.866 1.16 0.316 0.245 0.197 0.705 1.37 0.857 2.25 0.107 0.281 0.704 0.153 1.11 0.644 1.94 0.0028 0.265 0.992 0.004 1 0.6 1.7 PRS_PLINK_1.99526231496888e.08 FALSE 930 Allergic reaction to food Both 76 172 18 injuries & poisonings gray50 172, 76 19, 8 47, 23 39, 21 43, 20 0.113 0.154 0.464 0.333 1.12 0.837 1.52 -0.0687 0.533 0.898 0.047 0.934 0.34 2.63 0.234 0.522 0.654 0.184 1.26 0.483 3.49 -0.0563 0.538 0.917 0.038 0.945 0.339 2.72 PRS_PLINK_1.99526231496888e.08 FALSE 931 Contact dermatitis and other eczema due to plants [except food] Both 41 136 13 dermatologic firebrick 136, 41 16, 5 42, 8 28, 7 32, 15 0.0964 0.18 0.592 0.227 1.1 0.766 1.53 -0.264 0.681 0.698 0.156 0.768 0.202 3.07 -0.217 0.789 0.784 0.106 0.805 0.169 3.7 0.163 0.683 0.811 0.091 1.18 0.333 4.44 PRS_PLINK_1.99526231496888e.08 TRUE 938 Dermatitis due to solar radiation Both 281 472 13 dermatologic firebrick 472, 281 67, 38 153, 115 83, 40 115, 66 0.0386 0.086 0.653 0.185 1.04 0.876 1.22 0.147 0.268 0.582 0.235 1.16 0.691 1.96 -0.241 0.309 0.437 0.36 0.786 0.432 1.43 -0.081 0.275 0.768 0.115 0.922 0.542 1.57 PRS_PLINK_1.99526231496888e.08 FALSE 938.1 Acute dermatitis due to solar radiation Both 20 47 13 dermatologic firebrick 47, 20 6, 0 13, 2 10, 8 12, 9 0.624 0.429 0.146 0.836 1.87 0.856 4.46 0.846 1.56 0.588 0.231 2.33 0.071 9590 0.858 1.96 0.661 0.18 2.36 0.0416 799 1.7 1.7 0.316 0.5 5.48 0.317 958 PRS_PLINK_1.99526231496888e.08 TRUE 938.2 Chronic dermatitis due to solar radiation Both 269 461 13 dermatologic firebrick 461, 269 61, 36 152, 112 81, 38 112, 61 0.0149 0.0879 0.866 0.063 1.01 0.851 1.2 0.0166 0.277 0.952 0.021 1.02 0.595 1.75 -0.326 0.315 0.301 0.522 0.722 0.392 1.32 -0.2 0.285 0.483 0.316 0.819 0.472 1.42 PRS_PLINK_1.99526231496888e.08 FALSE 939 Atopic/contact dermatitis due to other or unspecified Both 435 537 13 dermatologic firebrick 537, 435 71, 59 174, 160 97, 60 130, 114 0.00196 0.0694 0.978 0.01 1 0.874 1.14 -0.0859 0.223 0.701 0.155 0.918 0.595 1.41 -0.394 0.256 0.124 0.907 0.674 0.41 1.1 -0.035 0.229 0.878 0.056 0.966 0.62 1.5 PRS_PLINK_1.99526231496888e.08 FALSE 939.1 Contact and allergic dermatitis of eyelid Both 13 24 13 dermatologic firebrick 24, 13 3, 2 7, 0 6, 4 5, 4 -0.0965 0.488 0.843 0.074 0.908 0.362 2.21 -0.238 2.75 0.931 0.031 0.788 0.00079 1.82 -1.68 1.98 0.397 0.402 0.186 0.000701 3.13 1.34 1.97 0.497 0.303 3.81 0.187 147 PRS_PLINK_1.99526231496888e.08 TRUE 941 Adverse reaction to serum or vaccine Both 8 36 18 injuries & poisonings gray50 36, 8 4, 1 13, 2 5, 0 9, 4 0.0783 0.284 0.783 0.106 1.08 0.451 1.67 -2.08 2.16 0.335 0.475 0.125 3.37e-10 3.5 -1.67 13.4 0.9 0.046 0.188 0.157 0.23 0.0955 1.58 0.952 0.021 1.1 0.0709 14.3 PRS_PLINK_1.99526231496888e.08 TRUE 942 Infusion and transfusion reaction Both 20 55 18 injuries & poisonings gray50 55, 20 7, 3 18, 4 10, 2 13, 7 -0.143 0.376 0.705 0.152 0.867 0.42 1.77 -0.774 1.01 0.442 0.354 0.461 0.0653 2.75 -0.607 1.14 0.594 0.226 0.545 0.0522 4.38 0.37 1.11 0.739 0.131 1.45 0.202 12.2 PRS_PLINK_1.99526231496888e.08 TRUE 946 Anaphylactic shock NOS Both 37 109 18 injuries & poisonings gray50 109, 37 12, 5 28, 9 25, 8 27, 8 -0.302 0.248 0.223 0.651 0.739 0.454 1.19 -0.629 0.769 0.413 0.384 0.533 0.123 2.27 -0.294 0.766 0.701 0.154 0.745 0.171 3.24 -0.581 0.716 0.417 0.38 0.559 0.138 2.15 PRS_PLINK_1.99526231496888e.08 TRUE 947 Urticaria Both 106 276 13 dermatologic firebrick 276, 106 31, 14 69, 27 69, 23 69, 33 0.0372 0.119 0.753 0.123 1.04 0.811 1.29 -0.216 0.435 0.62 0.208 0.806 0.351 1.88 -0.259 0.429 0.546 0.263 0.772 0.342 1.76 -0.167 0.425 0.694 0.158 0.846 0.374 1.93 PRS_PLINK_1.99526231496888e.08 FALSE 949 Allergies, other Both 425 536 18 injuries & poisonings gray50 536, 425 69, 55 176, 158 96, 64 130, 107 0.0673 0.0631 0.286 0.543 1.07 0.947 1.21 0.0773 0.225 0.731 0.136 1.08 0.699 1.67 -0.178 0.254 0.484 0.315 0.837 0.512 1.37 -0.0215 0.237 0.927 0.033 0.979 0.618 1.55 PRS_PLINK_1.99526231496888e.08 FALSE 952 Spinal cord injury without evidence of spinal bone injury Both 15 86 18 injuries & poisonings gray50 86, 15 12, 0 21, 4 22, 3 21, 6 0.574 0.416 0.168 0.775 1.78 0.821 4.3 2.2 1.66 0.184 0.736 9.06 0.25 1440 0.548 1.24 0.658 0.182 1.73 0.115 299 1.35 1.46 0.358 0.446 3.84 0.26 707 PRS_PLINK_1.99526231496888e.08 TRUE 957 Injury to other and unspecified nerves Both 5 42 18 injuries & poisonings gray50 42, 5 4, 1 12, 1 7, 1 11, 1 -0.44 0.614 0.474 0.325 0.644 0.196 2.18 -0.168 2.36 0.943 0.025 0.845 0.000835 231 1.3 5.51 0.813 0.09 3.68 1.14e-05 232000 -0.212 2.14 0.921 0.036 0.809 0.00294 578 PRS_PLINK_1.99526231496888e.08 TRUE 958 Certain early complications of trauma or procedure Both 35 277 18 injuries & poisonings gray50 277, 35 41, 4 97, 12 41, 7 69, 9 0.0952 0.126 0.449 0.348 1.1 0.858 1.38 0.405 0.587 0.49 0.31 1.5 0.487 5.53 0.343 0.668 0.608 0.216 1.41 0.381 5.56 0.339 0.654 0.604 0.219 1.4 0.393 5.79 PRS_PLINK_1.99526231496888e.08 TRUE 958.1 Postoperative shock Both 1 36 18 injuries & poisonings gray50 36, 1 5, 0 10, 0 8, 1 9, 0 -0.225 0.863 0.794 0.1 0.799 0.0518 14.1 1.55 2.41 0.52 0.284 4.71 0.13 63300 PRS_PLINK_1.99526231496888e.08 TRUE 958.2 Traumatic and surgical subcutaneous emphysema Both 3 24 18 injuries & poisonings gray50 24, 3 5, 2 7, 1 5, 0 6, 0 -0.446 1.12 0.692 0.16 0.64 0.0133 5.72 -1.9 3.07 0.535 0.272 0.149 0.00114 16.1 -0.999 3.12 0.749 0.126 0.368 0.000649 43.4 -1.71 3.53 0.628 0.202 0.181 7.87e-07 33.7 PRS_PLINK_1.99526231496888e.08 TRUE 960 Poisoning by antibiotics Both 92 541 18 injuries & poisonings gray50 541, 92 75, 12 181, 33 90, 17 134, 16 -0.161 0.138 0.243 0.614 0.851 0.643 1.11 0.16 0.373 0.669 0.175 1.17 0.574 2.53 0.0482 0.417 0.908 0.042 1.05 0.462 2.42 -0.375 0.41 0.361 0.443 0.687 0.304 1.57 PRS_PLINK_1.99526231496888e.08 FALSE 960.1 Adverse effects of antibacterials (not penicillins) Both 23 90 18 injuries & poisonings gray50 90, 23 13, 1 22, 6 22, 4 23, 7 -0.0536 0.304 0.86 0.065 0.948 0.528 1.72 2.1 1.23 0.0892 1.049 8.13 0.958 119 0.361 1.06 0.733 0.135 1.44 0.198 18.7 1.84 1.2 0.124 0.906 6.3 0.812 117 PRS_PLINK_1.99526231496888e.08 TRUE 960.2 Allergy/adverse effect of penicillin Both 52 385 18 injuries & poisonings gray50 385, 52 55, 7 126, 21 65, 11 95, 6 -0.232 0.185 0.208 0.681 0.793 0.543 1.13 0.293 0.469 0.532 0.274 1.34 0.548 3.61 0.149 0.513 0.772 0.112 1.16 0.42 3.33 -0.583 0.569 0.305 0.515 0.558 0.168 1.81 PRS_PLINK_1.99526231496888e.08 FALSE 961 Poisoning by other anti-infectives Both 32 142 18 injuries & poisonings gray50 142, 32 27, 3 43, 12 26, 3 36, 10 0.132 0.151 0.383 0.417 1.14 0.836 1.49 0.666 0.686 0.332 0.479 1.95 0.549 8.78 0.159 0.786 0.84 0.076 1.17 0.228 6.05 1.04 0.736 0.16 0.797 2.82 0.737 14.4 PRS_PLINK_1.99526231496888e.08 TRUE 961.1 Poisoning/allergy of sulfonamides Both 36 264 18 injuries & poisonings gray50 264, 36 38, 2 93, 6 40, 16 65, 8 0.162 0.128 0.205 0.688 1.18 0.934 1.53 0.139 0.768 0.857 0.067 1.15 0.255 6.83 1.84 0.701 0.00865 2.063 6.29 1.79 32.9 0.924 0.844 0.274 0.563 2.52 0.531 18.7 PRS_PLINK_1.99526231496888e.08 TRUE 962 Poisoning by hormones and synthetic substitutes Both 32 183 18 injuries & poisonings gray50 183, 32 29, 1 49, 12 42, 8 46, 9 0.242 0.259 0.349 0.457 1.27 0.768 2.17 1.6 0.858 0.0619 1.208 4.96 1.06 48.8 1.34 0.876 0.126 0.898 3.82 0.734 42.1 1.33 0.83 0.11 0.96 3.77 0.817 35.9 PRS_PLINK_1.99526231496888e.08 TRUE 962.1 Adrenal cortical steroids causing adverse effects in therapeutic use Both 14 68 18 injuries & poisonings gray50 68, 14 12, 2 22, 4 12, 3 17, 4 0.076 0.378 0.841 0.075 1.08 0.524 2.31 -0.0646 1.49 0.965 0.015 0.937 0.0203 1740 1.13 1.28 0.38 0.421 3.09 0.281 171 0.391 0.981 0.69 0.161 1.48 0.261 11.4 PRS_PLINK_1.99526231496888e.08 TRUE 962.2 Insulins and antidiabetic agents causing adverse effects in therapeutic use Both 2 27 18 injuries & poisonings gray50 27, 2 5, 1 9, 0 4, 1 7, 0 -1.14 1.07 0.288 0.54 0.32 0.0122 2.24 0.149 2.02 0.941 0.026 1.16 0.00243 45.1 -0.232 1170 1 0 0.793 0.658 2.06 -0.185 3170 1 0 0.831 0.789 1.88 PRS_PLINK_1.99526231496888e.08 TRUE 962.3 Hormones and synthetic substitutes causing adverse effects in therapeutic use Both 19 106 18 injuries & poisonings gray50 106, 19 17, 2 34, 8 18, 4 27, 5 0.249 0.337 0.46 0.337 1.28 0.668 2.58 0.319 0.792 0.687 0.163 1.38 0.322 7.74 0.834 1.05 0.427 0.37 2.3 0.323 32.2 0.325 0.823 0.693 0.16 1.38 0.292 8.69 PRS_PLINK_1.99526231496888e.08 TRUE 963 Poisoning by primarily systemic agents Both 103 543 18 injuries & poisonings gray50 543, 103 80, 14 192, 38 79, 16 136, 24 0.136 0.0957 0.156 0.807 1.15 0.951 1.38 0.241 0.355 0.497 0.304 1.27 0.647 2.64 -0.0118 0.4 0.976 0.01 0.988 0.448 2.18 0.128 0.371 0.73 0.136 1.14 0.552 2.42 PRS_PLINK_1.99526231496888e.08 FALSE 963.1 Antineoplastic and immunosuppressive drugs causing adverse effects Both 99 524 18 injuries & poisonings gray50 524, 99 82, 14 179, 36 80, 16 130, 22 0.137 0.0972 0.16 0.796 1.15 0.949 1.38 0.232 0.358 0.518 0.286 1.26 0.636 2.62 -0.0486 0.402 0.904 0.044 0.953 0.429 2.11 0.0975 0.374 0.794 0.1 1.1 0.532 2.36 PRS_PLINK_1.99526231496888e.08 FALSE 964 Poisoning by agents primarily affecting blood constituents Both 26 133 18 injuries & poisonings gray50 133, 26 21, 2 33, 6 33, 6 33, 11 0.386 0.17 0.0231 1.636 1.47 1.08 2.07 0.245 0.801 0.76 0.119 1.28 0.262 7.74 0.244 0.788 0.757 0.121 1.28 0.272 7.25 1.02 0.77 0.186 0.731 2.77 0.682 15.5 PRS_PLINK_1.99526231496888e.08 TRUE 964.1 Anticoagulants causing adverse effects Both 23 125 18 injuries & poisonings gray50 125, 23 19, 2 33, 5 29, 6 31, 9 0.272 0.325 0.402 0.396 1.31 0.696 2.57 0.196 0.844 0.817 0.088 1.22 0.222 8.3 0.289 0.816 0.723 0.141 1.34 0.276 7.8 0.527 0.785 0.502 0.299 1.69 0.39 9.71 PRS_PLINK_1.99526231496888e.08 TRUE 965 Poisoning by analgesics, antipyretics, and antirheumatics Both 41 222 18 injuries & poisonings gray50 222, 41 35, 5 75, 13 35, 6 56, 13 0.0752 0.166 0.651 0.186 1.08 0.74 1.44 0.123 0.57 0.829 0.081 1.13 0.386 3.69 0.0312 0.649 0.962 0.017 1.03 0.279 3.8 0.478 0.62 0.441 0.356 1.61 0.498 5.9 PRS_PLINK_1.99526231496888e.08 TRUE 965.1 Opiates and related narcotics causing adverse effects in therapeutic use Both 58 362 18 injuries & poisonings gray50 362, 58 50, 7 130, 22 50, 10 91, 14 0.0174 0.137 0.899 0.046 1.02 0.75 1.3 0.113 0.471 0.81 0.092 1.12 0.457 3.01 0.426 0.538 0.428 0.368 1.53 0.533 4.57 0.0803 0.489 0.869 0.061 1.08 0.421 2.99 PRS_PLINK_1.99526231496888e.08 FALSE 965.3 Salicylates causing adverse effects in therapeutic use Both 7 26 18 injuries & poisonings gray50 26, 7 3, 3 6, 1 6, 2 7, 1 -0.549 0.746 0.462 0.335 0.578 0.117 2.14 -0.197 2.76 0.943 0.025 0.822 0.00947 50.7 0.329 2.14 0.878 0.056 1.39 1.31 1.45 -1.52 1.85 0.41 0.387 0.218 0.000103 5.71 PRS_PLINK_1.99526231496888e.08 TRUE 966 Poisoning by anticonvulsants and anti-Parkinsonism drugs Both 2 27 18 injuries & poisonings gray50 27, 2 5, 0 7, 1 6, 1 7, 0 -0.429 0.767 0.576 0.24 0.651 0.0149 2.61 -0.00588 1.8 0.997 0.001 0.994 0.92 1.16 0.264 1730 1 0 1.3 0.706 3.56 PRS_PLINK_1.99526231496888e.08 TRUE 967 Adverse effects of sedatives or other central nervous system depressants and anesthetics Both 85 347 18 injuries & poisonings gray50 347, 85 48, 10 132, 33 41, 8 87, 21 -0.122 0.149 0.415 0.382 0.885 0.653 1.17 0.0807 0.403 0.841 0.075 1.08 0.506 2.47 0.0229 0.534 0.966 0.015 1.02 0.355 2.91 0.0488 0.427 0.909 0.041 1.05 0.464 2.47 PRS_PLINK_1.99526231496888e.08 FALSE 969 Poisoning by psychotropic agents Both 15 86 18 injuries & poisonings gray50 86, 15 14, 2 24, 3 18, 1 22, 8 0.318 0.241 0.188 0.727 1.37 0.922 2.43 0.212 1.03 0.838 0.077 1.24 0.117 15.1 -0.307 0.946 0.746 0.127 0.736 0.0848 4.98 0.802 0.81 0.322 0.492 2.23 0.531 12.3 PRS_PLINK_1.99526231496888e.08 TRUE 971 Poisoning by drugs primarily affecting the autonomic nervous system Both 1 10 18 injuries & poisonings gray50 10, 1 2, 0 2, 1 2, 0 3, 0 0.789 3.03 0.794 0.1 2.2 0.000116 485 0.00684 2380 1 0 1.01 0.781 1.08 PRS_PLINK_1.99526231496888e.08 TRUE 972 Poisoning by agents primarily affecting the cardiovascular system Both 5 32 18 injuries & poisonings gray50 32, 5 1, 0 9, 1 7, 3 8, 1 0.447 0.53 0.399 0.399 1.56 0.593 5.38 7.45 17.5 0.67 0.174 1710 1060 2750 -2.13 5.87 0.716 0.145 0.118 2.83e-06 379 2.2 6.31 0.728 0.138 9 0.000419 89000 PRS_PLINK_1.99526231496888e.08 TRUE 972.1 Cardiac rhythm regulators causing adverse effects in therapeutic use Both 1 8 18 injuries & poisonings gray50 8, 1 1, 0 2, 0 2, 1 2, 0 1.86 755 0.998 0.001 6.43 0.76 37.3 0.0651 1000 1 0 1.07 0.649 1.51 PRS_PLINK_1.99526231496888e.08 TRUE 972.6 Antihypertensive agents causing adverse effects Both 1 16 18 injuries & poisonings gray50 16, 1 2, 0 4, 1 4, 0 4, 0 0.177 1.29 0.891 0.05 1.19 0.0372 30.1 -0.643 3890 1 0 0.526 0.472 1.92 PRS_PLINK_1.99526231496888e.08 TRUE 974 Poisoning by water, mineral, and uric acid metabolism drugs Both 6 25 18 injuries & poisonings gray50 25, 6 3, 0 9, 1 3, 1 6, 3 0.161 0.61 0.792 0.101 1.17 0.372 3.67 -0.0653 3.76 0.986 0.006 0.937 1.01e-07 1670 0.429 6430 1 0 1.54 0.000296 6070 -0.935 7.6 0.902 0.045 0.393 3.45e-05 3060 PRS_PLINK_1.99526231496888e.08 TRUE 975 Poisoning by agents primarily acting on the smooth and skeletal muscles and respiratory system Both 7 31 18 injuries & poisonings gray50 31, 7 3, 1 8, 2 7, 3 8, 1 1.65 1.19 0.165 0.784 5.22 0.888 6.48 0.869 1.9 0.648 0.188 2.38 0.142 6800 -0.00585 1.9 0.998 0.001 0.994 0.0466 136 -1.64 3.37 0.626 0.203 0.193 0.000244 87.9 PRS_PLINK_1.99526231496888e.08 TRUE 976 Poisoning by agents primarily affecting skin & mucous membrane, ophthalmological, otorhinolaryngological, & dental drugs Both 4 16 18 injuries & poisonings gray50 16, 4 2, 1 4, 0 4, 2 4, 1 0.0722 0.482 0.881 0.055 1.07 0.439 2.6 0.0304 1620 1 0 1.03 0.839 1.56 0.222 3.54 0.95 0.022 1.25 1.16 1.44 -0.547 27.4 0.984 0.007 0.579 0.56 0.598 PRS_PLINK_1.99526231496888e.08 TRUE 977 Personal history of allergy to medicinal agents Both 66 411 18 injuries & poisonings gray50 411, 66 59, 4 138, 25 65, 13 102, 16 0.0343 0.142 0.809 0.092 1.03 0.766 1.34 0.925 0.562 0.0998 1.001 2.52 0.895 8.81 0.832 0.563 0.14 0.855 2.3 0.766 8.08 0.727 0.551 0.187 0.728 2.07 0.727 7.13 PRS_PLINK_1.99526231496888e.08 FALSE 979 Adverse drug events and drug allergies Both 165 778 18 injuries & poisonings gray50 778, 165 109, 23 252, 67 135, 31 194, 32 0.077 0.0799 0.336 0.474 1.08 0.916 1.25 0.235 0.271 0.385 0.414 1.26 0.753 2.19 0.0752 0.31 0.808 0.092 1.08 0.589 2 -0.331 0.304 0.275 0.561 0.718 0.395 1.32 PRS_PLINK_1.99526231496888e.08 FALSE 980 Encounter for long-term (current) use of antibiotics Both 45 263 1 infectious diseases blue 263, 45 32, 7 85, 10 45, 12 66, 11 0.165 0.224 0.463 0.334 1.18 0.761 1.86 -0.532 0.553 0.336 0.474 0.588 0.2 1.79 -0.0389 0.589 0.947 0.023 0.962 0.31 3.08 -0.133 0.615 0.828 0.082 0.875 0.27 3.04 PRS_PLINK_1.99526231496888e.08 TRUE 985 Toxic effect of other metals Both 3 20 18 injuries & poisonings gray50 20, 3 2, 0 5, 1 5, 0 5, 2 0.608 0.564 0.281 0.552 1.84 0.665 16.5 0.121 62.2 0.998 0.001 1.13 1.18 1.12 1.32 2.73 0.629 0.201 3.74 0.0811 264 PRS_PLINK_1.99526231496888e.08 TRUE 989 Toxic effect of other substances, chiefly nonmedicinal as to source Both 7 41 18 injuries & poisonings gray50 41, 7 8, 2 10, 0 10, 2 10, 2 0.469 0.759 0.536 0.271 1.6 0.346 10 -0.194 1.99 0.922 0.035 0.824 0.00362 31.1 -1.89 2.06 0.358 0.446 0.151 3.72e-07 9.75 0.616 1.29 0.632 0.199 1.85 0.223 8.21 PRS_PLINK_1.99526231496888e.08 TRUE 990 Effects radiation NOS Both 94 669 18 injuries & poisonings gray50 669, 94 108, 13 216, 30 116, 13 164, 22 -0.0283 0.127 0.824 0.084 0.972 0.742 1.23 0.123 0.354 0.728 0.138 1.13 0.571 2.35 -0.101 0.417 0.808 0.093 0.904 0.392 2.08 0.13 0.368 0.723 0.141 1.14 0.553 2.42 PRS_PLINK_1.99526231496888e.08 FALSE 994 Sepsis and SIRS Both 73 456 18 injuries & poisonings gray50 456, 73 75, 10 159, 23 65, 11 114, 19 0.0117 0.131 0.928 0.032 1.01 0.757 1.28 0.0761 0.408 0.852 0.069 1.08 0.492 2.49 0.285 0.459 0.535 0.272 1.33 0.536 3.34 0.215 0.413 0.603 0.22 1.24 0.557 2.9 PRS_PLINK_1.99526231496888e.08 FALSE 994.1 Systemic inflammatory response syndrome (SIRS) Both 10 64 18 injuries & poisonings gray50 64, 10 11, 2 15, 2 16, 2 16, 4 0.59 0.526 0.262 0.582 1.8 0.655 5.51 0.694 1.88 0.712 0.147 2 0.0644 19500000 0.218 1.35 0.872 0.06 1.24 0.0348 25.9 1.18 1.29 0.359 0.445 3.25 0.328 139 PRS_PLINK_1.99526231496888e.08 TRUE 994.2 Sepsis Both 69 423 18 injuries & poisonings gray50 423, 69 70, 9 149, 21 60, 11 105, 18 0.00859 0.133 0.949 0.023 1.01 0.748 1.27 0.0707 0.427 0.869 0.061 1.07 0.472 2.59 0.407 0.471 0.387 0.412 1.5 0.593 3.91 0.239 0.431 0.58 0.237 1.27 0.552 3.08 PRS_PLINK_1.99526231496888e.08 FALSE 994.21 Septic shock Both 14 111 18 injuries & poisonings gray50 111, 14 15, 3 31, 2 24, 4 28, 1 -0.575 0.362 0.112 0.95 0.562 0.263 1.15 -0.836 0.883 0.344 0.464 0.434 0.0412 2.58 -0.69 0.943 0.465 0.333 0.502 0.073 3.12 -1.56 1.18 0.187 0.728 0.21 0.00615 2.45 PRS_PLINK_1.99526231496888e.08 TRUE