phewas_code phewas_string sex MatchedCases MatchedControls groupnum group color N N_Q1 N_Q2 N_Q3 N_Q4 PRS_BETA PRS_SEBETA PRS_P PRS_LOG10P PRS_OR PRS_CI1 PRS_CI2 Q1Q2_BETA Q1Q2_SEBETA Q1Q2_P Q1Q2_LOG10P Q1Q2_OR Q1Q2_CI1 Q1Q2_CI2 Q1Q3_BETA Q1Q3_SEBETA Q1Q3_P Q1Q3_LOG10P Q1Q3_OR Q1Q3_CI1 Q1Q3_CI2 Q1Q4_BETA Q1Q4_SEBETA Q1Q4_P Q1Q4_LOG10P Q1Q4_OR Q1Q4_CI1 Q1Q4_CI2 predictor exclude 008 Intestinal infection Both 7 45 1 infectious diseases blue 45, 7 11, 1 11, 1 11, 3 11, 2 0.239 0.518 0.644 0.191 1.27 0.465 4 0.194 1.19 0.87 0.06 1.21 0.125 356 0.941 1.42 0.506 0.296 2.56 0.221 449 0.573 1.54 0.709 0.149 1.77 0.0578 117 PRS_PLINK_1.58489319246107e.102 TRUE 008.5 Bacterial enteritis Both 2 16 1 infectious diseases blue 16, 2 3, 0 4, 1 4, 1 4, 0 0.519 1.3 0.69 0.161 1.68 0.0402 42.5 0.831 761 0.999 0 2.3 0.265 31.4 0.297 366 0.999 0 1.35 0.105 4.39 PRS_PLINK_1.58489319246107e.102 TRUE 008.52 Intestinal infection due to C. difficile Both 1 11 1 infectious diseases blue 11, 1 3, 0 3, 1 2, 0 3, 0 0.697 2.31 0.763 0.117 2.01 0.0124 67.5 -0.183 275000 1 0 0.833 0.499 1.14 PRS_PLINK_1.58489319246107e.102 TRUE 008.6 Viral Enteritis Both 1 13 1 infectious diseases blue 13, 1 4, 0 3, 0 3, 0 3, 1 0.113 1.22 0.926 0.033 1.12 0.135 24.1 -0.107 2350 1 0 0.898 0.256 1.46 PRS_PLINK_1.58489319246107e.102 TRUE 010 Tuberculosis Both 2 3 1 infectious diseases blue 3, 2 1, 1 1, 1 1, 0 1, 1 -0.197 7780000 1 0 0.822 0.294 1.87 -2.18 3.02e+09 1 0 0.113 3.46e-26 1.04e+20 0.0509 71.4 0.999 0 1.05 0.719 1.13 PRS_PLINK_1.58489319246107e.102 TRUE 031 Diseases due to other mycobacteria Both 1 2 1 infectious diseases blue 2, 1 1, 0 1, 1 1, 0 1, 1 -0.0243 905 1 0 0.976 0.614 1.23 -0.0322 280 1 0 0.968 0.771 1.14 PRS_PLINK_1.58489319246107e.102 TRUE 038 Septicemia Both 1 34 1 infectious diseases blue 34, 1 8, 0 8, 0 8, 1 9, 0 0.00727 0.599 0.99 0.004 1.01 0.239 48 1.35 2.13 0.526 0.279 3.86 0.0914 10000 PRS_PLINK_1.58489319246107e.102 TRUE 038.1 Gram negative septicemia Both 1 9 1 infectious diseases blue 9, 1 3, 0 2, 0 2, 1 2, 0 -0.719 9.79 0.941 0.026 0.487 0.000192 1840 0.000294 126 1 0 1 0.887 1.05 PRS_PLINK_1.58489319246107e.102 TRUE 038.2 Gram positive septicemia Both 0 3 1 infectious diseases blue 3, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 038.3 Bacteremia Both 0 18 1 infectious diseases blue 18, 0 5 4 4 5 PRS_PLINK_1.58489319246107e.102 TRUE 041 Bacterial infection NOS Both 4 52 1 infectious diseases blue 52, 4 12, 0 13, 0 13, 2 13, 2 0.421 0.495 0.395 0.403 1.52 0.559 6.21 1.05 1.28 0.413 0.384 2.86 0.295 459 0.332 1.37 0.809 0.092 1.39 0.0484 49.6 PRS_PLINK_1.58489319246107e.102 TRUE 041.1 Staphylococcus infections Both 2 26 1 infectious diseases blue 26, 2 7, 0 6, 0 6, 1 7, 1 0.191 0.862 0.825 0.084 1.21 0.0186 28.6 -0.0589 1.8 0.974 0.011 0.943 0.00236 36.3 0.708 2.08 0.734 0.134 2.03 0.0315 434 PRS_PLINK_1.58489319246107e.102 TRUE 041.11 Methicillin sensitive Staphylococcus aureus Both 2 16 1 infectious diseases blue 16, 2 4, 0 4, 0 4, 1 4, 1 -0.164 1.04 0.875 0.058 0.849 0.0453 193 -0.00578 16.5 1 0 0.994 0.862 1.14 9.19e-13 10.3 1 0 1 7.92e-09 9600000 PRS_PLINK_1.58489319246107e.102 TRUE 041.12 Methicillin resistant Staphylococcus aureus Both 2 14 1 infectious diseases blue 14, 2 4, 0 3, 1 3, 0 4, 1 0.183 1.85 0.921 0.036 1.2 0.000781 63.9 0.0274 393 1 0 1.03 0.813 3.01 0.431 260000 1 0 1.54 0.23 2.89 PRS_PLINK_1.58489319246107e.102 TRUE 041.2 Streptococcus infection Both 2 17 1 infectious diseases blue 17, 2 5, 0 4, 0 4, 0 4, 2 0.141 0.731 0.847 0.072 1.15 0.191 25.6 -0.186 3.27 0.955 0.02 0.83 0.774 0.9 PRS_PLINK_1.58489319246107e.102 TRUE 041.21 Rheumatic fever / chorea Both 0 1 1 infectious diseases blue 1, 0 PRS_PLINK_1.58489319246107e.102 TRUE 041.4 E. coli Both 2 12 1 infectious diseases blue 12, 2 3, 0 3, 0 3, 1 3, 1 0.892 1.38 0.517 0.287 2.44 0.317 34.9 -0.0286 4490 1 0 0.972 0.314 4.6 -0.0735 1590 1 0 0.929 0.543 1.94 PRS_PLINK_1.58489319246107e.102 TRUE 041.8 H. pylori Both 0 2 1 infectious diseases blue 2, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 041.9 Infection with drug-resistant microorganisms Both 0 5 1 infectious diseases blue 5, 0 2 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 053 Herpes zoster Both 3 22 1 infectious diseases blue 22, 3 5, 1 5, 1 5, 0 6, 1 -0.164 1.04 0.875 0.058 0.848 0.00507 24.9 -0.45 1.84 0.806 0.093 0.638 0.00458 11.9 -0.335 2.12 0.874 0.058 0.716 0.637 1.13 5.09 6.87 0.458 0.339 163 0.0217 229 PRS_PLINK_1.58489319246107e.102 TRUE 053.1 Herpes zoster with nervous system complications Both 1 3 1 infectious diseases blue 3, 1 1, 0 1, 0 1, 1 1, 0 -0.446 5020 1 0 0.64 0.564 1.72 0.00571 77.9 1 0 1.01 0.58 1.92 PRS_PLINK_1.58489319246107e.102 TRUE 054 Herpes simplex Both 3 22 1 infectious diseases blue 22, 3 5, 1 5, 0 5, 1 6, 1 -0.0269 0.562 0.962 0.017 0.973 0.296 14.9 0.135 15.1 0.993 0.003 1.14 0.000233 5410 -1.52 2.89 0.6 0.222 0.22 0.000474 178 0.37 1.55 0.812 0.09 1.45 0.126 30.4 PRS_PLINK_1.58489319246107e.102 TRUE 070 Viral hepatitis Both 1 8 1 infectious diseases blue 8, 1 2, 0 2, 1 2, 0 2, 0 0.887 21.3 0.967 0.015 2.43 3.47 1.94 2.06 5910 1 0 7.81 0.000917 30.5 PRS_PLINK_1.58489319246107e.102 TRUE 070.2 Viral hepatitis B Both 1 1 1 infectious diseases blue 1, 1 0.00309 85.9 1 0 1 0.961 1.05 PRS_PLINK_1.58489319246107e.102 TRUE 070.3 Viral hepatitis C Both 0 7 1 infectious diseases blue 7, 0 2 2 1 2 PRS_PLINK_1.58489319246107e.102 TRUE 070.4 Chronic hepatitis Both 0 1 1 infectious diseases blue 1, 0 PRS_PLINK_1.58489319246107e.102 TRUE 070.9 Hepatitis NOS Both 3 9 1 infectious diseases blue 9, 3 3, 2 2, 1 2, 0 2, 0 0.493 6.96 0.944 0.025 1.64 1.49 1.76 0.029 845 1 0 1.03 0.623 1.77 -0.177 3930 1 0 0.838 0.692 1.7 0.0911 2000 1 0 1.1 0.119 11.2 PRS_PLINK_1.58489319246107e.102 TRUE 071 Human immunodeficiency virus [HIV] disease Both 0 2 1 infectious diseases blue 2, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 071.1 HIV infection, symptomatic Both 0 2 1 infectious diseases blue 2, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 078 Viral warts & HPV Both 10 34 1 infectious diseases blue 34, 10 8, 3 8, 1 8, 2 9, 4 0.227 0.44 0.605 0.218 1.26 0.563 4.35 -0.0494 1.23 0.968 0.014 0.952 0.0968 65 2.24 2.4 0.351 0.455 9.4 0.0875 1350000 1.03 1.25 0.413 0.384 2.79 0.377 3750 PRS_PLINK_1.58489319246107e.102 TRUE 079 Viral infection Both 13 38 1 infectious diseases blue 38, 13 9, 4 9, 1 9, 3 10, 5 0.25 0.351 0.476 0.322 1.28 0.689 2.6 -0.291 1.16 0.802 0.096 0.748 0.0868 6.8 1.23 1.45 0.395 0.403 3.43 0.293 211 0.117 1.16 0.92 0.036 1.12 0.139 10.7 PRS_PLINK_1.58489319246107e.102 TRUE 079.1 Varicella infection Both 8 32 1 infectious diseases blue 32, 8 7, 3 8, 1 8, 1 8, 3 0.233 0.505 0.645 0.19 1.26 0.485 4.29 0.312 1.52 0.837 0.077 1.37 0.095 806 -0.406 1.88 0.829 0.082 0.666 0.00414 1830 0.347 1.67 0.835 0.078 1.42 0.0907 1100 PRS_PLINK_1.58489319246107e.102 TRUE 079.2 Infectious mononucleosis Both 0 4 1 infectious diseases blue 4, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 079.9 Viremia, NOS Both 2 12 1 infectious diseases blue 12, 2 3, 0 3, 0 3, 0 3, 2 -0.0824 0.803 0.918 0.037 0.921 0.184 47.8 2.23 123 0.985 0.006 9.33 4.64e-06 19600000 PRS_PLINK_1.58489319246107e.102 TRUE 080 Postoperative infection Both 0 29 1 infectious diseases blue 29, 0 7 7 7 7 PRS_PLINK_1.58489319246107e.102 TRUE 081 Infection/inflammation of internal prosthetic device; implant; and graft Both 3 15 1 infectious diseases blue 15, 3 3, 0 4, 0 3, 1 4, 2 0.175 1.03 0.866 0.063 1.19 0.227 32.1 0.15 2820 1 0 1.16 0.00873 41.6 -0.21 536 1 0 0.811 0.777 3.22 PRS_PLINK_1.58489319246107e.102 TRUE 090 Sexually transmitted infections (not HIV or hepatitis) Both 2 19 1 infectious diseases blue 19, 2 4, 0 5, 1 4, 0 5, 1 0.0927 0.585 0.874 0.058 1.1 0.345 7.54 -0.332 2.21 0.88 0.055 0.718 0.0228 19.3 -0.0357 66.9 1 0 0.965 0.000818 1.14 PRS_PLINK_1.58489319246107e.102 TRUE 110 Dermatophytosis / Dermatomycosis Both 13 33 1 infectious diseases blue 33, 13 9, 4 8, 2 8, 3 8, 3 -0.142 0.419 0.735 0.134 0.868 0.366 1.87 -1.05 1.35 0.438 0.359 0.351 0.00311 3.67 0.112 1.44 0.938 0.028 1.12 0.0207 23.4 -0.661 1.26 0.601 0.221 0.517 0.0168 5.53 PRS_PLINK_1.58489319246107e.102 TRUE 110.1 Dermatophytosis Both 13 31 1 infectious diseases blue 31, 13 8, 3 8, 3 7, 3 8, 3 -0.127 0.436 0.771 0.113 0.881 0.354 2.01 -0.97 1.43 0.498 0.303 0.379 0.00117 4.75 0.81 1.29 0.529 0.276 2.25 0.00169 47.3 -0.866 1.41 0.538 0.269 0.421 4.06e-05 27.8 PRS_PLINK_1.58489319246107e.102 TRUE 110.11 Dermatophytosis of nail Both 9 18 1 infectious diseases blue 18, 9 5, 3 4, 1 4, 1 5, 3 -0.275 0.574 0.631 0.2 0.759 0.179 2.33 -0.0751 1.48 0.96 0.018 0.928 0.486 10.3 0.159 2.84 0.955 0.02 1.17 0.000703 269 -1.7 1.83 0.354 0.451 0.183 0.00893 3.53 PRS_PLINK_1.58489319246107e.102 TRUE 110.12 Althete's foot Both 4 15 1 infectious diseases blue 15, 4 4, 2 4, 1 3, 0 4, 1 -1.63 1.19 0.171 0.766 0.196 0.00135 1.19 -1.74 2.71 0.52 0.284 0.175 0.000384 9.73 -0.0724 916 1 0 0.93 0.197 1.52 -0.0236 851 1 0 0.977 0.465 1.3 PRS_PLINK_1.58489319246107e.102 TRUE 110.13 Dermatophytosis of the body Both 2 16 1 infectious diseases blue 16, 2 4, 1 4, 0 4, 1 4, 0 -0.0285 0.831 0.973 0.012 0.972 0.177 3000 -0.937 27.9 0.973 0.012 0.392 0.000293 0.373 1.18 4550000 1 0 3.24 0.000471 7730 -0.629 7130000 1 0 0.533 8.78e-07 35.6 PRS_PLINK_1.58489319246107e.102 TRUE 110.2 Dermatomycoses Both 2 7 1 infectious diseases blue 7, 2 2, 1 2, 0 1, 1 2, 0 -0.334 6.63 0.96 0.018 0.716 0.205 2.5 -0.00742 1.19e+08 1 0 0.993 4.22e-09 1.03e+08 13 14700 0.999 0 453000 7.69e-14 1.93e+22 0.00996 751 1 0 1.01 0.884 1.17 PRS_PLINK_1.58489319246107e.102 TRUE 112 Candidiasis Both 7 35 1 infectious diseases blue 35, 7 9, 1 9, 0 8, 4 9, 2 0.577 0.72 0.423 0.373 1.78 0.398 15.4 0.131 1.45 0.928 0.033 1.14 0.0328 47.9 0.891 1.48 0.546 0.263 2.44 0.124 1690 -0.319 1.62 0.844 0.074 0.727 0.0114 830 PRS_PLINK_1.58489319246107e.102 TRUE 112.3 Candidiasis of skin and nails Both 0 4 1 infectious diseases blue 4, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 117 Mycoses Both 2 4 1 infectious diseases blue 4, 2 1, 0 1, 1 1, 0 1, 1 -0.0742 1210 1 0 0.929 0.724 1.27 0.00144 59.1 1 0 1 0.965 1.05 -0.00774 43.2 1 0 0.992 0.895 1.2 PRS_PLINK_1.58489319246107e.102 TRUE 117.4 Aspergillosis Both 2 1 1 infectious diseases blue 1, 2 2.11e-05 7.14 1 0 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 130 Spirochetal infection Both 1 3 1 infectious diseases blue 3, 1 1, 0 1, 0 0, 1 1, 0 0.0129 1050 1 0 1.01 0.689 2.16 -0.0183 4.93 0.997 0.001 0.982 0.928 1.06 PRS_PLINK_1.58489319246107e.102 TRUE 130.1 Lyme disease Both 0 2 1 infectious diseases blue 2, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 131 Protozoan infection Both 0 2 1 infectious diseases blue 2, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 134 Helminthiases Both 1 1 1 infectious diseases blue 1, 1 -0.00223 40.2 1 0 0.998 0.667 1.09 PRS_PLINK_1.58489319246107e.102 TRUE 134.1 Intestinal helminthiases Both 1 0 1 infectious diseases blue 0, 1 PRS_PLINK_1.58489319246107e.102 TRUE 136 Other infectious and parasitic diseases Both 6 41 1 infectious diseases blue 41, 6 10, 1 10, 0 10, 1 10, 4 0.418 0.533 0.433 0.364 1.52 0.505 6.51 -0.246 1.31 0.851 0.07 0.782 0.00534 37.8 -2.06 2.1 0.327 0.486 0.128 8.87e-05 10.7 0.436 1.37 0.75 0.125 1.55 0.0342 38.4 PRS_PLINK_1.58489319246107e.102 TRUE 145 Cancer of mouth Both 1 10 2 neoplasms darkcyan 10, 1 2, 0 2, 0 2, 0 3, 1 -0.00102 1.6 0.999 0 0.999 0.0486 22.7 0.122 1570 1 0 1.13 0.887 1.25 PRS_PLINK_1.58489319246107e.102 TRUE 145.1 Cancer of lip Both 0 1 2 neoplasms darkcyan 1, 0 PRS_PLINK_1.58489319246107e.102 TRUE 145.2 Cancer of tongue Both 0 2 2 neoplasms darkcyan 2, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 145.3 Cancer of major salivary glands Both 1 2 2 neoplasms darkcyan 2, 1 1, 1 1, 0 1, 1 1, 0 16.6 2.87e+09 1 0 16200000 3.14e-27 1.13e+35 22.9 58500 1 0 8.99e+09 8.69e-16 6.14e+31 PRS_PLINK_1.58489319246107e.102 TRUE 145.4 Cancer of the gums Both 0 2 2 neoplasms darkcyan 2, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 149 Cancer of larynx, pharynx, nasal cavities Both 1 10 2 neoplasms darkcyan 10, 1 2, 0 2, 0 2, 1 3, 0 -0.00416 1.29 0.997 0.001 0.996 0.108 9 0.183 2330 1 0 1.2 3.04e-12 3.36e+16 PRS_PLINK_1.58489319246107e.102 TRUE 149.1 Cancer of oropharynx Both 0 3 2 neoplasms darkcyan 3, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 149.2 Cancer of nasopharynx Both 0 1 2 neoplasms darkcyan 1, 0 PRS_PLINK_1.58489319246107e.102 TRUE 149.4 Cancer of larynx Both 0 3 2 neoplasms darkcyan 3, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 149.5 Hx of malignant neoplasm of oral cavity and pharynx Both 1 3 2 neoplasms darkcyan 3, 1 1, 0 1, 0 0, 1 1, 0 0.154 12600 1 0 1.17 0.543 3.61 -0.00888 59.9 1 0 0.991 0.86 1.44 PRS_PLINK_1.58489319246107e.102 TRUE 149.9 Cancer of of nasal cavities Both 0 1 2 neoplasms darkcyan 1, 0 PRS_PLINK_1.58489319246107e.102 TRUE 150 Cancer of esophagus Both 0 3 2 neoplasms darkcyan 3, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 151 Cancer of stomach Both 1 1 2 neoplasms darkcyan 1, 1 -0.00231 68.2 1 0 0.998 0.953 1.05 PRS_PLINK_1.58489319246107e.102 TRUE 153 Colorectal cancer Both 0 9 2 neoplasms darkcyan 9, 0 3 2 2 2 PRS_PLINK_1.58489319246107e.102 TRUE 153.2 Colon cancer Both 0 6 2 neoplasms darkcyan 6, 0 2 1 1 2 PRS_PLINK_1.58489319246107e.102 TRUE 153.3 Malignant neoplasm of rectum, rectosigmoid junction, and anus Both 0 3 2 neoplasms darkcyan 3, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 155 Cancer of liver and intrahepatic bile duct Both 0 4 2 neoplasms darkcyan 4, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 155.1 Malignant neoplasm of liver, primary Both 0 4 2 neoplasms darkcyan 4, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 157 Pancreatic cancer Both 0 2 2 neoplasms darkcyan 2, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 158 Neoplasm of unspecified nature of digestive system Both 2 10 2 neoplasms darkcyan 10, 2 3, 0 2, 0 2, 0 3, 2 2.23 3.43 0.516 0.287 9.28 0.103 10.6 0.0586 2260 1 0 1.06 0.687 1.76 PRS_PLINK_1.58489319246107e.102 TRUE 159 Malignant neoplasm of other and ill-defined sites within the digestive organs and peritoneum Both 1 9 2 neoplasms darkcyan 9, 1 3, 0 2, 0 2, 0 2, 1 -0.917 2.35 0.696 0.157 0.4 0.379 0.422 -0.379 5390 1 0 0.685 0.000138 223 PRS_PLINK_1.58489319246107e.102 TRUE 159.2 Malignant neoplasm of small intestine, including duodenum Both 0 2 2 neoplasms darkcyan 2, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 159.3 Malignant neoplasm of gallbladder and extrahepatic bile ducts Both 0 2 2 neoplasms darkcyan 2, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 159.4 Malignant neoplasm of retroperitoneum and peritoneum Both 0 1 2 neoplasms darkcyan 1, 0 PRS_PLINK_1.58489319246107e.102 TRUE 165 Cancer within the respiratory system Both 0 12 2 neoplasms darkcyan 12, 0 3 3 3 3 PRS_PLINK_1.58489319246107e.102 TRUE 165.1 Cancer of bronchus; lung Both 0 10 2 neoplasms darkcyan 10, 0 3 2 2 3 PRS_PLINK_1.58489319246107e.102 TRUE 170 Cancer of bone and connective tissue Both 0 15 2 neoplasms darkcyan 15, 0 3 4 3 4 PRS_PLINK_1.58489319246107e.102 TRUE 170.1 Bone cancer Both 0 12 2 neoplasms darkcyan 12, 0 2 3 3 3 PRS_PLINK_1.58489319246107e.102 TRUE 170.2 Cancer of connective tissue Both 0 5 2 neoplasms darkcyan 5, 0 2 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 172 Skin cancer Both 5 43 2 neoplasms darkcyan 43, 5 10, 0 11, 3 10, 2 11, 0 0.0121 0.501 0.981 0.008 1.01 0.31 3.5 1.17 1.3 0.368 0.434 3.23 0.356 244 1.12 1.36 0.412 0.385 3.06 0.278 1260 PRS_PLINK_1.58489319246107e.102 TRUE 172.1 Melanomas of skin, dx or hx Both 4 33 2 neoplasms darkcyan 33, 4 9, 0 8, 1 8, 3 8, 0 0.377 0.703 0.592 0.228 1.46 0.33 14.7 0.173 1.48 0.907 0.043 1.19 0.0916 109 0.746 1.42 0.599 0.222 2.11 0.139 77.4 PRS_PLINK_1.58489319246107e.102 TRUE 172.11 Melanomas of skin Both 1 19 2 neoplasms darkcyan 19, 1 5, 0 5, 0 4, 1 5, 0 -0.301 0.924 0.744 0.128 0.74 0.0417 12.7 0.895 5.19 0.863 0.064 2.45 2.27 2.63 PRS_PLINK_1.58489319246107e.102 TRUE 172.2 Other non-epithelial cancer of skin Both 4 37 2 neoplasms darkcyan 37, 4 9, 0 9, 2 9, 2 9, 0 -0.0444 0.508 0.93 0.031 0.957 0.297 3.16 -0.0437 1.59 0.978 0.01 0.957 0.00894 54.3 1.2 1.46 0.412 0.385 3.32 0.238 266 PRS_PLINK_1.58489319246107e.102 TRUE 172.21 Basal cell carcinoma Both 4 22 2 neoplasms darkcyan 22, 4 6, 2 5, 1 5, 1 6, 0 -0.133 0.754 0.86 0.066 0.875 0.224 4.32 -0.666 1.99 0.738 0.132 0.514 0.483 0.57 -1.07 2.4 0.656 0.183 0.343 0.000307 106 -1.1 2.52 0.664 0.178 0.334 0.00183 33.1 PRS_PLINK_1.58489319246107e.102 TRUE 172.22 Squamous cell carcinoma Both 0 12 2 neoplasms darkcyan 12, 0 3 3 3 3 PRS_PLINK_1.58489319246107e.102 TRUE 172.3 Carcinoma in situ of skin Both 0 11 2 neoplasms darkcyan 11, 0 3 3 2 3 PRS_PLINK_1.58489319246107e.102 TRUE 173 Neoplasm of uncertain behavior of skin Both 1 26 2 neoplasms darkcyan 26, 1 6, 0 6, 1 6, 0 7, 0 -0.3 0.65 0.645 0.191 0.741 0.103 5.59 0.356 3.7 0.924 0.035 1.43 0.000144 1060 PRS_PLINK_1.58489319246107e.102 TRUE 174 Breast cancer Both 3 18 2 neoplasms darkcyan 18, 3 4, 1 4, 1 4, 1 5, 0 0.316 0.653 0.629 0.202 1.37 0.197 16.3 -0.354 2.34 0.88 0.056 0.702 0.00186 929 4.15 30.2 0.891 0.05 63.1 46 85.4 1.37 4.79 0.775 0.11 3.92 3.62 4.25 PRS_PLINK_1.58489319246107e.102 TRUE 174.1 Breast cancer [female] Female 3 19 2 neoplasms darkcyan 19, 3 4, 1 5, 2 4, 0 5, 0 0.323 0.657 0.623 0.205 1.38 0.251 17.8 -0.391 2.22 0.86 0.065 0.676 0.00202 115 1.5 205 0.994 0.003 4.49 3.93 4.97 0.158 3.01 0.958 0.019 1.17 0.00751 94.4 PRS_PLINK_1.58489319246107e.102 TRUE 174.11 Malignant neoplasm of female breast Female 3 18 2 neoplasms darkcyan 18, 3 4, 1 4, 1 4, 1 5, 0 0.316 0.653 0.629 0.202 1.37 0.197 16.3 -0.354 2.34 0.88 0.056 0.702 0.00186 929 4.15 30.2 0.891 0.05 63.1 46 85.4 1.37 4.79 0.775 0.11 3.92 3.62 4.25 PRS_PLINK_1.58489319246107e.102 TRUE 174.3 Neoplasm of uncertain behavior of breast Both 0 2 2 neoplasms darkcyan 2, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 175 Acquired absence of breast Female 1 5 2 neoplasms darkcyan 5, 1 2, 1 1, 0 1, 0 1, 0 -0.2 52 0.997 0.001 0.819 0.366 0.883 0.308 6340 1 0 1.36 0.177 11.4 0.475 6610 1 0 1.61 0.257 1.83 0.0393 5690 1 0 1.04 0.198 5.98 PRS_PLINK_1.58489319246107e.102 TRUE 180 Cervical cancer and dysplasia Female 2 11 2 neoplasms darkcyan 11, 2 2, 1 3, 0 2, 0 3, 1 0.465 1.09 0.668 0.175 1.59 0.182 16 -0.0344 627 1 0 0.966 0.575 1.56 0.669 11800000 1 0 1.95 0.0486 41.2 -0.865 15500000 1 0 0.421 8.9e-05 711 PRS_PLINK_1.58489319246107e.102 TRUE 180.1 Cervical cancer Female 1 4 2 neoplasms darkcyan 4, 1 1, 0 1, 0 1, 1 1, 0 0.0642 1540 1 0 1.07 0.792 1.7 PRS_PLINK_1.58489319246107e.102 TRUE 180.3 Cervical intraepithelial neoplasia [CIN] [Cervical dysplasia] Female 1 11 2 neoplasms darkcyan 11, 1 2, 1 3, 0 2, 0 3, 0 0.625 1.63 0.701 0.154 1.87 0.0511 288 -0.00311 1040 1 0 0.997 0.445 1.51 0.669 11800000 1 0 1.95 0.0486 41.2 -0.49 54.2 0.993 0.003 0.612 0.000233 275 PRS_PLINK_1.58489319246107e.102 TRUE 182 Malignant neoplasm of uterus Female 0 5 2 neoplasms darkcyan 5, 0 2 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 184 Cancer of other female genital organs Female 0 6 2 neoplasms darkcyan 6, 0 1 1 1 2 PRS_PLINK_1.58489319246107e.102 TRUE 184.1 Malignant neoplasm of ovary and other uterine adnexa Female 0 2 2 neoplasms darkcyan 2, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 184.11 Malignant neoplasm of ovary Female 0 3 2 neoplasms darkcyan 3, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 184.2 Cancer of other female genital organs (excluding uterus and ovary) Female 0 5 2 neoplasms darkcyan 5, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 185 Cancer of prostate Male 0 9 2 neoplasms darkcyan 9, 0 3 2 2 2 PRS_PLINK_1.58489319246107e.102 TRUE 187 Cancer of other male genital organs Male 1 2 2 neoplasms darkcyan 2, 1 1, 0 1, 1 1, 0 1, 1 -0.28 3060 1 0 0.755 0.613 1.61 -15.8 422000 1 0 1.43e-07 4.1e-24 3.92e+14 PRS_PLINK_1.58489319246107e.102 TRUE 187.2 Malignant neoplasm of testis Male 1 3 2 neoplasms darkcyan 3, 1 1, 0 1, 0 1, 1 1, 0 0.00111 70 1 0 1 0.339 3.84 -15.8 422000 1 0 1.43e-07 4.1e-24 3.92e+14 PRS_PLINK_1.58489319246107e.102 TRUE 187.8 Neoplasm of uncertain behavior of male genital organs Male 0 1 2 neoplasms darkcyan 1, 0 PRS_PLINK_1.58489319246107e.102 TRUE 189 Cancer of urinary organs (incl. kidney and bladder) Both 0 19 2 neoplasms darkcyan 19, 0 5 5 4 5 PRS_PLINK_1.58489319246107e.102 TRUE 189.1 Cancer of kidney and renal pelvis Both 0 10 2 neoplasms darkcyan 10, 0 3 2 2 3 PRS_PLINK_1.58489319246107e.102 TRUE 189.11 Malignant neoplasm of kidney, except pelvis Both 0 9 2 neoplasms darkcyan 9, 0 3 2 2 2 PRS_PLINK_1.58489319246107e.102 TRUE 189.12 Malignant neoplasm of renal pelvis Both 0 3 2 neoplasms darkcyan 3, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 189.2 Cancer of bladder Both 0 10 2 neoplasms darkcyan 10, 0 3 2 2 3 PRS_PLINK_1.58489319246107e.102 TRUE 189.21 Malignant neoplasm of bladder Both 0 8 2 neoplasms darkcyan 8, 0 2 2 2 2 PRS_PLINK_1.58489319246107e.102 TRUE 189.4 Malignant neoplasm of other urinary organs Both 0 2 2 neoplasms darkcyan 2, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 190 Cancer of eye Both 0 1 2 neoplasms darkcyan 1, 0 PRS_PLINK_1.58489319246107e.102 TRUE 191 Manlignant and unknown neoplasms of brain and nervous system Both 0 10 2 neoplasms darkcyan 10, 0 3 2 2 3 PRS_PLINK_1.58489319246107e.102 TRUE 191.1 Cancer of brain and nervous system Both 0 7 2 neoplasms darkcyan 7, 0 2 2 1 2 PRS_PLINK_1.58489319246107e.102 TRUE 191.11 Cancer of brain Both 0 8 2 neoplasms darkcyan 8, 0 2 2 2 2 PRS_PLINK_1.58489319246107e.102 TRUE 193 Thyroid cancer Both 0 16 2 neoplasms darkcyan 16, 0 4 4 4 4 PRS_PLINK_1.58489319246107e.102 TRUE 194 Cancer of other endocrine glands Both 0 11 2 neoplasms darkcyan 11, 0 2 3 2 3 PRS_PLINK_1.58489319246107e.102 TRUE 195 Cancer, suspected or other Both 9 48 2 neoplasms darkcyan 48, 9 11, 1 12, 3 12, 3 12, 2 0.382 0.438 0.383 0.417 1.47 0.624 4.1 0.545 1.15 0.636 0.197 1.72 0.167 23.8 1.6 1.8 0.372 0.429 4.96 0.0973 795000 0.944 1.33 0.479 0.32 2.57 0.208 418 PRS_PLINK_1.58489319246107e.102 TRUE 195.1 Malignant neoplasm, other Both 8 49 2 neoplasms darkcyan 49, 8 12, 1 12, 1 12, 5 12, 1 0.339 0.432 0.432 0.365 1.4 0.609 3.85 -0.402 1.38 0.77 0.113 0.669 0.0299 60.8 1.3 1.32 0.324 0.49 3.68 0.333 114 0.688 1.4 0.624 0.205 1.99 0.143 344 PRS_PLINK_1.58489319246107e.102 TRUE 195.3 Malignant neoplasm of head, face, and neck Both 0 8 2 neoplasms darkcyan 8, 0 1 2 2 2 PRS_PLINK_1.58489319246107e.102 TRUE 196 Radiotherapy Both 0 14 2 neoplasms darkcyan 14, 0 3 3 3 4 PRS_PLINK_1.58489319246107e.102 TRUE 197 Chemotherapy Both 1 33 2 neoplasms darkcyan 33, 1 8, 0 8, 0 8, 0 8, 1 0.155 0.522 0.767 0.115 1.17 0.232 10.8 0.129 1.94 0.947 0.024 1.14 0.000202 297 PRS_PLINK_1.58489319246107e.102 TRUE 198 Secondary malignant neoplasm Both 0 31 2 neoplasms darkcyan 31, 0 7 8 7 8 PRS_PLINK_1.58489319246107e.102 TRUE 198.1 Secondary malignancy of lymph nodes Both 0 25 2 neoplasms darkcyan 25, 0 6 6 6 6 PRS_PLINK_1.58489319246107e.102 TRUE 198.2 Secondary malignancy of respiratory organs Both 0 6 2 neoplasms darkcyan 6, 0 2 1 1 2 PRS_PLINK_1.58489319246107e.102 TRUE 198.3 Secondary malignant neoplasm of digestive systems Both 0 5 2 neoplasms darkcyan 5, 0 2 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 198.4 Secondary malignant neoplasm of liver Both 0 6 2 neoplasms darkcyan 6, 0 2 1 1 2 PRS_PLINK_1.58489319246107e.102 TRUE 198.5 Secondary malignancy of brain/spine Both 0 7 2 neoplasms darkcyan 7, 0 2 2 1 2 PRS_PLINK_1.58489319246107e.102 TRUE 198.6 Secondary malignancy of bone Both 0 9 2 neoplasms darkcyan 9, 0 2 2 2 2 PRS_PLINK_1.58489319246107e.102 TRUE 199 Neoplasm of uncertain behavior Both 4 48 2 neoplasms darkcyan 48, 4 11, 0 12, 1 12, 0 12, 3 0.497 0.579 0.391 0.408 1.64 0.344 9.32 0.874 1.3 0.501 0.3 2.4 0.133 214 1.54 1.49 0.3 0.523 4.67 0.322 30900 PRS_PLINK_1.58489319246107e.102 TRUE 199.4 Neurofibromatosis Both 0 1 2 neoplasms darkcyan 1, 0 PRS_PLINK_1.58489319246107e.102 TRUE 200 Myeloproliferative disease Both 0 13 2 neoplasms darkcyan 13, 0 4 3 3 3 PRS_PLINK_1.58489319246107e.102 TRUE 200.1 Polycythemia vera Both 0 5 2 neoplasms darkcyan 5, 0 2 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 201 Hodgkin's disease Both 0 2 2 neoplasms darkcyan 2, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 202 Cancer of other lymphoid, histiocytic tissue Both 1 15 2 neoplasms darkcyan 15, 1 3, 0 4, 0 3, 1 4, 0 0.82 1.26 0.516 0.287 2.27 0.32 128 0.528 3830 1 0 1.7 0.383 6.6 PRS_PLINK_1.58489319246107e.102 TRUE 202.2 Non-Hodgkins lymphoma Both 1 14 2 neoplasms darkcyan 14, 1 3, 0 3, 0 3, 1 4, 0 0.519 1.09 0.635 0.197 1.68 0.282 157 0.528 3830 1 0 1.7 0.383 6.6 PRS_PLINK_1.58489319246107e.102 TRUE 202.21 Nodular lymphoma Both 1 8 2 neoplasms darkcyan 8, 1 2, 0 2, 0 2, 1 2, 0 2.45 57.6 0.966 0.015 11.6 0.00871 15900 0.311 10700 1 0 1.36 0.191 5.66 PRS_PLINK_1.58489319246107e.102 TRUE 202.22 Reticulosarcoma Both 0 3 2 neoplasms darkcyan 3, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 202.24 Large cell lymphoma Both 0 1 2 neoplasms darkcyan 1, 0 PRS_PLINK_1.58489319246107e.102 TRUE 204 Leukemia Both 1 10 2 neoplasms darkcyan 10, 1 3, 0 2, 0 2, 0 3, 1 0.235 3.34 0.944 0.025 1.26 1.23 1.43 0.0469 261 1 0 1.05 0.76 1.56 PRS_PLINK_1.58489319246107e.102 TRUE 204.1 Lymphoid leukemia Both 0 5 2 neoplasms darkcyan 5, 0 2 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 204.11 Lymphoid leukemia, acute Both 0 3 2 neoplasms darkcyan 3, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 204.12 Lymphoid leukemia, chronic Both 0 2 2 neoplasms darkcyan 2, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 204.2 Myeloid leukemia Both 0 7 2 neoplasms darkcyan 7, 0 2 2 1 2 PRS_PLINK_1.58489319246107e.102 TRUE 204.21 Myeloid leukemia, acute Both 0 4 2 neoplasms darkcyan 4, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 204.4 Multiple myeloma Both 0 2 2 neoplasms darkcyan 2, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 208 Benign neoplasm of colon Both 24 38 2 neoplasms darkcyan 38, 24 9, 1 9, 8 9, 10 10, 5 0.438 0.322 0.175 0.758 1.55 0.88 3.01 1.65 1.18 0.164 0.785 5.2 0.702 201 3.63 2.15 0.0915 1.039 37.6 1.38 4.95e+10 2.14 1.5 0.153 0.814 8.53 0.868 1780 PRS_PLINK_1.58489319246107e.102 TRUE 209 Neuroendocrine tumors Both 1 3 2 neoplasms darkcyan 3, 1 1, 0 1, 0 1, 1 1, 0 -1.25 159000 1 0 0.287 0.034 667000 -0.000244 43.3 1 0 1 0.977 1.03 PRS_PLINK_1.58489319246107e.102 TRUE 210 Benign neoplasm of lip, oral cavity, and pharynx Both 2 17 2 neoplasms darkcyan 17, 2 5, 0 4, 2 4, 0 4, 0 0.297 0.827 0.719 0.143 1.35 0.0151 28.1 2.5 7.66 0.745 0.128 12.1 10.8 13.7 PRS_PLINK_1.58489319246107e.102 TRUE 211 Benign neoplasm of other parts of digestive system Both 19 43 2 neoplasms darkcyan 43, 19 10, 4 11, 3 10, 3 11, 9 0.418 0.334 0.211 0.676 1.52 0.834 2.98 -0.445 0.982 0.65 0.187 0.641 0.0757 3.62 -0.548 1.22 0.654 0.185 0.578 0.0446 5.04 0.591 0.927 0.523 0.281 1.81 0.359 10.9 PRS_PLINK_1.58489319246107e.102 TRUE 212 Benign neoplasm of respiratory and intrathoracic organs Both 4 14 2 neoplasms darkcyan 14, 4 4, 1 3, 0 3, 1 4, 2 0.302 0.851 0.723 0.141 1.35 0.0771 8.56 1.04 15300000 1 0 2.82 1.98e-07 259000 -0.216 1.97 0.912 0.04 0.806 0.553 0.94 -4.13 5.2 0.427 0.369 0.0161 7.56e-07 14.7 PRS_PLINK_1.58489319246107e.102 TRUE 213 Benign neoplasm of bone and articular cartilage Both 0 14 2 neoplasms darkcyan 14, 0 3 3 3 4 PRS_PLINK_1.58489319246107e.102 TRUE 214 Lipoma Both 3 12 2 neoplasms darkcyan 12, 3 3, 0 3, 2 3, 0 3, 1 -0.155 0.904 0.864 0.063 0.857 0.000688 5.53 0.1 18200000 1 0 1.11 0.00595 1840 -1.48 13300000 1 0 0.227 4.81e-06 5450 PRS_PLINK_1.58489319246107e.102 TRUE 214.1 Lipoma of skin and subcutaneous tissue Both 1 6 2 neoplasms darkcyan 6, 1 2, 0 1, 0 1, 0 2, 1 6.66e-05 577 1 0 1 0.865 1.19 -1.48e-06 139 1 0 1 0.628 1.5 PRS_PLINK_1.58489319246107e.102 TRUE 215 Other benign neoplasm of connective and other soft tissue Both 9 45 2 neoplasms darkcyan 45, 9 11, 1 11, 2 11, 4 11, 2 -0.175 0.429 0.683 0.165 0.84 0.316 1.96 0.425 1.29 0.742 0.13 1.53 0.0441 47.2 2.22 1.76 0.207 0.685 9.24 0.0836 44300 -0.204 1.44 0.887 0.052 0.816 0.017 11.4 PRS_PLINK_1.58489319246107e.102 TRUE 216 Benign neoplasm of skin Both 20 44 2 neoplasms darkcyan 44, 20 10, 7 11, 2 11, 6 11, 5 0.167 0.336 0.62 0.207 1.18 0.638 2.32 -0.791 1 0.431 0.366 0.453 0.042 2.56 -0.786 1.03 0.446 0.35 0.456 0.0357 2.83 -0.289 0.97 0.766 0.116 0.749 0.124 4.08 PRS_PLINK_1.58489319246107e.102 TRUE 216.1 Screening for malignant neoplasms of the skin Both 0 5 2 neoplasms darkcyan 5, 0 2 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 217 Vascular hamartomas and non-neoplastic nevi Both 1 16 2 neoplasms darkcyan 16, 1 4, 0 4, 0 4, 1 4, 0 0.122 0.631 0.846 0.073 1.13 0.287 6.46 -0.12 170 0.999 0 0.887 0.326 1.34 PRS_PLINK_1.58489319246107e.102 TRUE 217.1 Nevus, non-neoplastic Both 1 15 2 neoplasms darkcyan 15, 1 4, 0 4, 0 3, 1 4, 0 0.0854 0.626 0.891 0.05 1.09 0.272 4.68 -0.0695 121 1 0 0.933 0.466 1.22 PRS_PLINK_1.58489319246107e.102 TRUE 218 Benign neoplasm of uterus Female 10 18 2 neoplasms darkcyan 18, 10 4, 3 4, 2 4, 2 5, 3 -0.231 0.455 0.611 0.214 0.793 0.348 1.72 -0.678 1.7 0.69 0.161 0.508 0.00558 9.09 -1.7 3.24 0.6 0.222 0.183 0.000542 20.5 -2.22 2.54 0.382 0.418 0.108 7.16e-06 5.34 PRS_PLINK_1.58489319246107e.102 TRUE 218.1 Uterine leiomyoma Female 3 16 2 neoplasms darkcyan 16, 3 3, 2 4, 0 4, 0 4, 1 0.0299 0.621 0.962 0.017 1.03 0.336 3.18 -2.34 4.64 0.614 0.212 0.096 3.26e-05 63.1 -7.81 818 0.992 0.003 0.000406 1.13e-31 1.08e+20 -2.91 7.4 0.694 0.159 0.0544 0.0434 0.0689 PRS_PLINK_1.58489319246107e.102 TRUE 218.2 Other benign neoplasm of uterus Female 10 17 2 neoplasms darkcyan 17, 10 4, 3 4, 2 4, 1 4, 4 -0.235 0.457 0.607 0.217 0.791 0.346 1.71 -0.678 1.7 0.69 0.161 0.508 0.00558 9.09 -6.06 5.22 0.245 0.61 0.00232 1.43e-07 2.23 -0.837 2.34 0.72 0.143 0.433 0.000293 21.6 PRS_PLINK_1.58489319246107e.102 TRUE 220 Benign neoplasm of ovary Female 1 8 2 neoplasms darkcyan 8, 1 1, 0 2, 0 2, 0 2, 1 1.05 2.59 0.686 0.164 2.85 2.62 3.06 -0.00112 470 1 0 0.999 0.785 1.24 PRS_PLINK_1.58489319246107e.102 TRUE 221 Benign neoplasm of other female genital organs Female 5 13 2 neoplasms darkcyan 13, 5 3, 0 3, 1 3, 2 3, 2 0.562 0.891 0.528 0.277 1.75 0.242 13.9 -0.0415 350 1 0 0.959 0.437 2 0.0029 127 1 0 1 0.791 1.46 1.25 9520000 1 0 3.47 0.00972 60100 PRS_PLINK_1.58489319246107e.102 TRUE 222 Benign neoplasm of male genital organs Male 1 8 2 neoplasms darkcyan 8, 1 2, 0 2, 0 2, 0 2, 1 0.395 31.9 0.99 0.004 1.48 1.37 1.62 0.0285 1440 1 0 1.03 0.48 1.91 PRS_PLINK_1.58489319246107e.102 TRUE 223 Benign neoplasm of kidney and other urinary organs Both 2 7 2 neoplasms darkcyan 7, 2 2, 1 2, 0 1, 0 2, 1 0.544 25.4 0.983 0.008 1.72 1.57 1.9 0.398 1130 1 0 1.49 0.739 1.52 0.00485 43.3 1 0 1 0.931 1.11 0.128 1990 1 0 1.14 0.621 4.35 PRS_PLINK_1.58489319246107e.102 TRUE 224 Benign neoplasm of eye Both 2 8 2 neoplasms darkcyan 8, 2 2, 2 2, 0 2, 0 2, 0 -0.432 12.6 0.973 0.012 0.649 0.324 0.598 0.174 3190 1 0 1.19 0.582 5.24 0.0336 1140 1 0 1.03 0.585 1.28 -0.0104 1280 1 0 0.99 0.592 1.54 PRS_PLINK_1.58489319246107e.102 TRUE 224.1 Benign neoplasm of eye, uveal Both 2 10 2 neoplasms darkcyan 10, 2 3, 2 2, 0 2, 0 3, 0 0.198 1.81 0.913 0.04 1.22 0.0145 34.7 0.298 2320 1 0 1.35 0.0835 3.92 -0.165 1240 1 0 0.848 0.342 1.86 -0.177 1890 1 0 0.838 0.319 1.84 PRS_PLINK_1.58489319246107e.102 TRUE 225 Benign neoplasm of brain and other parts of nervous system Both 0 13 2 neoplasms darkcyan 13, 0 4 3 3 3 PRS_PLINK_1.58489319246107e.102 TRUE 225.1 Benign neoplasm of brain, cranial nerves, meninges Both 0 11 2 neoplasms darkcyan 11, 0 3 3 2 3 PRS_PLINK_1.58489319246107e.102 TRUE 225.2 Benign neoplasm of spinal cord, meninges Both 0 3 2 neoplasms darkcyan 3, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 226 Benign neoplasm of thyroid glands Both 0 14 2 neoplasms darkcyan 14, 0 4 3 3 4 PRS_PLINK_1.58489319246107e.102 TRUE 227 Benign neoplasm of other endocrine glands and related structures Both 0 16 2 neoplasms darkcyan 16, 0 4 4 4 4 PRS_PLINK_1.58489319246107e.102 TRUE 227.1 Benign neoplasm of adrenal gland Both 0 5 2 neoplasms darkcyan 5, 0 2 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 227.2 Benign neoplasm of parathyroid gland Both 0 7 2 neoplasms darkcyan 7, 0 2 2 1 2 PRS_PLINK_1.58489319246107e.102 TRUE 227.3 Benign neoplasm of pituitary gland and craniopharyngeal duct (pouch) Both 0 4 2 neoplasms darkcyan 4, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 228 Hemangioma and lymphangioma, any site Both 1 28 2 neoplasms darkcyan 28, 1 7, 0 7, 0 7, 1 7, 0 0.369 0.837 0.659 0.181 1.45 0.0566 19.2 0.301 2.04 0.882 0.054 1.35 0.0122 268 PRS_PLINK_1.58489319246107e.102 TRUE 228.1 Hemangioma of skin and subcutaneous tissue Both 1 16 2 neoplasms darkcyan 16, 1 4, 0 4, 0 4, 1 4, 0 0.16 0.921 0.862 0.065 1.17 0.223 67.5 -1.76 268 0.995 0.002 0.172 2.22e-05 398 PRS_PLINK_1.58489319246107e.102 TRUE 229 Benign neoplasm of unspecified sites Both 4 45 2 neoplasms darkcyan 45, 4 11, 2 11, 0 11, 1 11, 1 0.293 0.654 0.654 0.185 1.34 0.0845 13.7 -0.4 1.23 0.746 0.127 0.671 0.0432 26.5 -0.299 1.29 0.816 0.088 0.742 0.0165 22.1 0.0487 1.72 0.977 0.01 1.05 0.0209 1990 PRS_PLINK_1.58489319246107e.102 TRUE 229.1 Benign neoplasm of lymph nodes Both 1 30 2 neoplasms darkcyan 30, 1 7, 0 7, 1 7, 0 8, 0 -0.0273 0.549 0.96 0.018 0.973 0.0659 4.92 0.327 1.67 0.845 0.073 1.39 0.000541 781 PRS_PLINK_1.58489319246107e.102 TRUE 240 Simple and unspecified goiter Both 2 15 3 endocrine/metabolic brown 15, 2 3, 1 4, 0 3, 0 4, 1 0.0994 1.1 0.928 0.033 1.1 0.0763 20.7 1.7 567 0.998 0.001 5.48 2.36 0.428 0.161 723 1 0 1.17 0.803 1.23 -0.153 818 1 0 0.858 0.384 1.22 PRS_PLINK_1.58489319246107e.102 TRUE 241 Nontoxic nodular goiter Both 1 31 3 endocrine/metabolic brown 31, 1 7, 1 8, 0 7, 0 8, 0 -0.0138 0.747 0.985 0.006 0.986 0.124 31.7 -0.586 2.1 0.78 0.108 0.557 0.00119 44.6 0.165 2.04 0.936 0.029 1.18 0.0169 10600 -0.32 2.21 0.885 0.053 0.726 0.000246 102 PRS_PLINK_1.58489319246107e.102 TRUE 241.1 Nontoxic uninodular goiter Both 0 30 3 endocrine/metabolic brown 30, 0 7 7 7 8 PRS_PLINK_1.58489319246107e.102 TRUE 241.2 Nontoxic multinodular goiter Both 0 16 3 endocrine/metabolic brown 16, 0 4 4 4 4 PRS_PLINK_1.58489319246107e.102 TRUE 242 Thyrotoxicosis with or without goiter Both 2 20 3 endocrine/metabolic brown 20, 2 4, 2 5, 0 5, 0 5, 0 -0.326 1 0.745 0.128 0.722 0.0804 25.9 -0.553 10.5 0.958 0.019 0.575 0.555 0.597 -0.316 4.56 0.945 0.025 0.729 0.000342 749 -0.000136 486 1 0 1 0.766 1.6 PRS_PLINK_1.58489319246107e.102 TRUE 242.1 Graves' disease Both 1 9 3 endocrine/metabolic brown 9, 1 2, 1 2, 0 2, 0 2, 0 0.00228 243 1 0 1 0.778 1.15 -0.444 10900 1 0 0.642 0.506 3.83 0.0333 1070 1 0 1.03 0.809 1.06 -0.104 4710 1 0 0.901 0.254 2.89 PRS_PLINK_1.58489319246107e.102 TRUE 242.2 Toxic multinodular goiter Both 0 2 3 endocrine/metabolic brown 2, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 242.3 Exophthalmos Both 2 5 3 endocrine/metabolic brown 5, 2 2, 2 1, 0 1, 0 1, 0 -0.00512 357 1 0 0.995 0.805 1.26 -0.0549 3730 1 0 0.947 0.35 2.39 -0.563 15600 1 0 0.57 0.385 24.4 0.267 7210 1 0 1.31 0.233 1.43 PRS_PLINK_1.58489319246107e.102 TRUE 242.31 Thyrotoxic exophthalmos Both 1 2 3 endocrine/metabolic brown 2, 1 1, 1 1, 0 1, 1 1, 0 0.0453 1920 1 0 1.05 0.694 1.61 -0.265 4290 1 0 0.767 0.543 1.79 PRS_PLINK_1.58489319246107e.102 TRUE 244 Hypothyroidism Both 11 44 3 endocrine/metabolic brown 44, 11 10, 9 11, 0 11, 1 11, 1 -0.99 0.447 0.0266 1.576 0.371 0.141 0.801 -4.74 2.59 0.0669 1.174 0.00873 1.16e-11 0.468 -4.06 1.88 0.0308 1.512 0.0173 2.78e-20 0.34 -1.29 1.23 0.295 0.531 0.276 0.014 2.32 PRS_PLINK_1.58489319246107e.102 TRUE 244.1 Secondary hypothyroidism Both 2 28 3 endocrine/metabolic brown 28, 2 7, 2 7, 0 7, 0 7, 0 -0.848 0.957 0.375 0.426 0.428 0.0139 3.49 -1.11 2.59 0.667 0.176 0.328 0.000394 85.4 0.593 2.5 0.812 0.09 1.81 0.00324 1080 0.174 1.83 0.924 0.034 1.19 0.0355 55.8 PRS_PLINK_1.58489319246107e.102 TRUE 244.2 Acquired hypothyroidism Both 5 21 3 endocrine/metabolic brown 21, 5 6, 4 5, 0 5, 0 5, 1 -0.585 0.738 0.428 0.368 0.557 0.121 1.91 3.67 19.6 0.851 0.07 39.3 6.94e-13 3.6e+18 -0.114 949 1 0 0.893 0.408 1.47 0.208 1.47 0.887 0.052 1.23 0.0889 20 PRS_PLINK_1.58489319246107e.102 TRUE 244.4 Hypothyroidism NOS Both 10 44 3 endocrine/metabolic brown 44, 10 10, 8 11, 0 11, 1 11, 1 -0.842 0.477 0.0778 1.109 0.431 0.155 0.993 -3.41 1.99 0.0863 1.064 0.033 2.32e-11 0.727 -3.66 1.78 0.0395 1.404 0.0258 4.34e-05 0.442 -1.17 1.25 0.348 0.458 0.31 0.0082 2.87 PRS_PLINK_1.58489319246107e.102 TRUE 245 Thyroiditis Both 1 16 3 endocrine/metabolic brown 16, 1 4, 1 4, 0 4, 0 4, 0 -0.341 1.9 0.857 0.067 0.711 0.00198 35.4 -3.17 75.7 0.967 0.015 0.042 5.86e-11 26.2 -2.16 15.2 0.887 0.052 0.115 0.0858 0.284 -0.635 7.22 0.93 0.032 0.53 0.0777 0.519 PRS_PLINK_1.58489319246107e.102 TRUE 245.2 Chronic thyroiditis Both 1 14 3 endocrine/metabolic brown 14, 1 4, 1 3, 0 3, 0 4, 0 -0.777 2.92 0.79 0.102 0.46 9.35e-05 141 -0.0373 39100000 1 0 0.963 0.00157 2390 -1.14 101 0.991 0.004 0.318 3.87e-07 255000 0.527 3.4 0.877 0.057 1.69 1.55 1.79 PRS_PLINK_1.58489319246107e.102 TRUE 245.21 Chronic lymphocytic thyroiditis Both 1 13 3 endocrine/metabolic brown 13, 1 4, 1 3, 0 3, 0 3, 0 -0.63 2.86 0.826 0.083 0.533 0.000108 146 3.52 4320 0.999 0 33.8 0.0784 95.7 0.258 253 0.999 0 1.29 0.0629 1.41 0.449 3.98 0.91 0.041 1.57 1.54 1.61 PRS_PLINK_1.58489319246107e.102 TRUE 246 Other disorders of thyroid Both 8 40 3 endocrine/metabolic brown 40, 8 9, 5 10, 1 10, 1 10, 1 -0.796 0.532 0.135 0.871 0.451 0.119 1.18 -1.75 1.32 0.183 0.737 0.173 4.13e-07 1.5 -2.55 1.62 0.114 0.944 0.0777 2.07e-06 1.41 -2.35 1.73 0.175 0.756 0.0952 2.03e-09 1.81 PRS_PLINK_1.58489319246107e.102 TRUE 246.2 Thyroid cyst Both 0 2 3 endocrine/metabolic brown 2, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 246.7 Abnormal results of function study of thyroid Both 1 16 3 endocrine/metabolic brown 16, 1 4, 1 4, 0 4, 0 4, 0 -0.451 2.38 0.85 0.071 0.637 9.8e-05 74.9 1.09 19.9 0.956 0.019 2.96 0.646 35.2 1.59 3820 1 0 4.91 0.649 21.8 1.23 66.6 0.985 0.006 3.43 0.0431 423 PRS_PLINK_1.58489319246107e.102 TRUE 249 Secondary diabetes mellitus Both 7 5 3 endocrine/metabolic brown 5, 7 2, 1 1, 0 1, 3 1, 3 -0.667 2.5 0.79 0.103 0.513 0.00599 28.2 -1.17 1810 0.999 0 0.309 0.00662 786 0.227 1960000 1 0 1.25 0.0551 27.7 0.00943 80.9 1 0 1.01 0.924 1.22 PRS_PLINK_1.58489319246107e.102 TRUE 250 Diabetes mellitus Both 32 29 3 endocrine/metabolic brown 29, 32 8, 8 7, 5 7, 9 7, 9 -0.571 0.483 0.237 0.625 0.565 0.144 1.39 -1.21 1.32 0.361 0.443 0.298 0.000212 4.06 -1.02 1.53 0.507 0.295 0.361 0.000485 17.9 -2.6 1.79 0.147 0.832 0.0744 7.37e-05 1.45 PRS_PLINK_1.58489319246107e.102 TRUE 250.1 Type 1 diabetes Both 29 8 3 endocrine/metabolic brown 8, 29 2, 10 2, 6 2, 5 2, 7 -0.416 0.752 0.58 0.237 0.66 0.0524 2.65 0.0363 1.8 0.984 0.007 1.04 0.0105 298 0.181 2.06 0.93 0.032 1.2 0.00142 985 -0.121 2.03 0.953 0.021 0.886 0.000237 577 PRS_PLINK_1.58489319246107e.102 TRUE 250.11 Type 1 diabetes with ketoacidosis Both 6 1 3 endocrine/metabolic brown 1, 6 0.0212 675 1 0 1.02 0.67 2.05 PRS_PLINK_1.58489319246107e.102 TRUE 250.12 Type 1 diabetes with renal manifestations Both 17 3 3 endocrine/metabolic brown 3, 17 1, 8 1, 2 1, 6 1, 8 -0.235 0.949 0.804 0.095 0.79 0.0595 42.1 -0.473 2.82 0.867 0.062 0.623 0.000708 61.6 0.274 2.29 0.905 0.043 1.31 0.00198 228 PRS_PLINK_1.58489319246107e.102 TRUE 250.13 Type 1 diabetes with ophthalmic manifestations Both 21 4 3 endocrine/metabolic brown 4, 21 1, 12 1, 1 1, 1 1, 6 0.0216 0.744 0.977 0.01 1.02 0.066 7.99 -0.466 2.74 0.865 0.063 0.628 0.00176 152 -0.339 2.69 0.9 0.046 0.712 0.000167 365 -0.932 2.42 0.7 0.155 0.394 0.000576 2450 PRS_PLINK_1.58489319246107e.102 TRUE 250.14 Type 1 diabetes with neurological manifestations Both 22 4 3 endocrine/metabolic brown 4, 22 1, 8 1, 3 1, 3 1, 7 -0.0595 0.896 0.947 0.024 0.942 0.0569 12.4 0.0759 2.68 0.977 0.01 1.08 0.00278 224 0.826 5.34 0.877 0.057 2.28 9.05e-06 32300 1.14 1.96 0.559 0.253 3.14 0.0651 1290 PRS_PLINK_1.58489319246107e.102 TRUE 250.15 Diabetes type 1 with peripheral circulatory disorders Both 4 1 3 endocrine/metabolic brown 1, 4 -0.0182 1800 1 0 0.982 0.647 1.5 PRS_PLINK_1.58489319246107e.102 TRUE 250.2 Type 2 diabetes Both 30 26 3 endocrine/metabolic brown 26, 30 7, 8 6, 4 6, 8 7, 9 -0.377 0.468 0.421 0.376 0.686 0.175 1.7 -0.928 1.34 0.49 0.31 0.395 9.54e-06 4.82 0.254 1.54 0.87 0.061 1.29 0.00287 912 -2.66 1.94 0.17 0.769 0.0701 0.052 1.72 PRS_PLINK_1.58489319246107e.102 TRUE 250.21 Type 2 diabetes with ketoacidosis Both 6 0 3 endocrine/metabolic brown 0, 6 PRS_PLINK_1.58489319246107e.102 TRUE 250.22 Type 2 diabetes with renal manifestations Both 4 6 3 endocrine/metabolic brown 6, 4 2, 1 1, 1 1, 0 2, 2 1.32e-15 4.1 1 0 1 0.0023 427 -0.0227 19100 1 0 0.978 0.136 16.7 0.0186 20.4 0.999 0 1.02 0.449 1.17 -8.16 1780 0.996 0.002 0.000285 5.53e-13 12900000 PRS_PLINK_1.58489319246107e.102 TRUE 250.23 Type 2 diabetes with ophthalmic manifestations Both 19 7 3 endocrine/metabolic brown 7, 19 2, 2 2, 6 1, 3 2, 8 -0.316 1.2 0.792 0.101 0.729 0.0179 11 0.66 2.88 0.819 0.087 1.93 0.000158 753 0.00606 28.6 1 0 1.01 0.839 1.2 -1.4 3.03 0.645 0.19 0.247 0.000175 21.7 PRS_PLINK_1.58489319246107e.102 TRUE 250.24 Type 2 diabetes with neurological manifestations Both 18 10 3 endocrine/metabolic brown 10, 18 3, 6 2, 2 2, 4 3, 5 0.234 0.693 0.736 0.133 1.26 0.13 8.03 0.145 2.89 0.96 0.018 1.16 0.000353 1190 0.823 4.23 0.846 0.073 2.28 4.62e-05 1740 0.249 2.08 0.905 0.044 1.28 0.0219 168 PRS_PLINK_1.58489319246107e.102 TRUE 250.25 Diabetes type 2 with peripheral circulatory disorders Both 2 3 3 endocrine/metabolic brown 3, 2 1, 1 1, 0 1, 1 1, 1 0.0629 8790 1 0 1.06 0.186 3.64 -0.017 12.7 0.999 0 0.983 0.892 1.23 0.538 6940000 1 0 1.71 4.42e-12 413 PRS_PLINK_1.58489319246107e.102 TRUE 250.3 Insulin pump user Both 21 13 3 endocrine/metabolic brown 13, 21 4, 7 3, 1 3, 6 3, 7 -0.824 0.736 0.263 0.58 0.439 0.0626 1.57 -2.26 2.16 0.296 0.529 0.105 0.000847 12.9 0.281 2.13 0.895 0.048 1.32 3.47e-05 6470 -2.54 2.14 0.234 0.631 0.0787 8.15e-05 8.63 PRS_PLINK_1.58489319246107e.102 TRUE 250.4 Abnormal glucose Both 29 27 3 endocrine/metabolic brown 27, 29 7, 7 7, 4 6, 8 7, 9 -0.171 0.521 0.743 0.129 0.843 0.0924 2.45 -0.704 1.3 0.588 0.23 0.494 0.000836 6.87 0.804 1.53 0.601 0.221 2.23 0.00196 571 -1.06 1.73 0.54 0.268 0.347 4.12e-05 51.9 PRS_PLINK_1.58489319246107e.102 TRUE 250.41 Impaired fasting glucose Both 8 15 3 endocrine/metabolic brown 15, 8 4, 1 4, 1 3, 2 4, 4 0.837 1.29 0.515 0.288 2.31 0.118 50.7 -2.1e-12 25.3 1 0 1 0.873 5580 0.916 84.4 0.991 0.004 2.5 2.35 2.21e+08 -0.609 8.98 0.946 0.024 0.544 7.14e-12 41800000 PRS_PLINK_1.58489319246107e.102 TRUE 250.42 Other abnormal glucose Both 29 27 3 endocrine/metabolic brown 27, 29 7, 7 7, 4 6, 8 7, 9 -0.171 0.521 0.743 0.129 0.843 0.0924 2.45 -0.704 1.3 0.588 0.23 0.494 0.000836 6.87 0.804 1.53 0.601 0.221 2.23 0.00196 571 -1.06 1.73 0.54 0.268 0.347 4.12e-05 51.9 PRS_PLINK_1.58489319246107e.102 TRUE 250.6 Polyneuropathy in diabetes Both 22 7 3 endocrine/metabolic brown 7, 22 2, 8 2, 6 1, 1 2, 6 0.0461 0.656 0.944 0.025 1.05 0.141 5.57 -0.0868 2.37 0.971 0.013 0.917 0.00193 535 0.0499 2.4 0.983 0.007 1.05 0.00187 177 0.579 2.08 0.781 0.107 1.78 0.0385 1540 PRS_PLINK_1.58489319246107e.102 TRUE 250.7 Diabetic retinopathy Both 21 10 3 endocrine/metabolic brown 10, 21 2, 3 2, 7 2, 4 3, 7 0.14 0.522 0.789 0.103 1.15 0.459 3.03 0.456 2.19 0.835 0.078 1.58 0.0328 1270 0.294 3.52 0.933 0.03 1.34 0.00861 551 -1.85 2.32 0.427 0.37 0.158 0.000135 4.38 PRS_PLINK_1.58489319246107e.102 TRUE 251 Other disorders of pancreatic internal secretion Both 10 16 3 endocrine/metabolic brown 16, 10 4, 6 4, 2 4, 0 4, 1 -0.747 0.601 0.215 0.668 0.474 0.08 1.25 -0.424 2.51 0.866 0.063 0.654 0.00237 910 -1.82 1.9 0.338 0.471 0.162 2.09e-05 2.26 0.237 2.2 0.914 0.039 1.27 0.00221 92500 PRS_PLINK_1.58489319246107e.102 TRUE 251.1 Hypoglycemia Both 11 5 3 endocrine/metabolic brown 5, 11 2, 5 1, 2 1, 1 1, 2 -0.542 0.907 0.55 0.26 0.582 0.0401 3.18 -0.0189 16800000 1 0 0.981 0.00778 556 0.0511 1430 1 0 1.05 0.035 7.84 -0.062 3460000 1 0 0.94 0.393 3.63 PRS_PLINK_1.58489319246107e.102 TRUE 252 Disorders of parathyroid gland Both 2 21 3 endocrine/metabolic brown 21, 2 6, 0 5, 1 5, 0 5, 1 -0.0919 1.08 0.932 0.031 0.912 0.0407 1130 0.145 1.94 0.94 0.027 1.16 0.00436 51.9 -0.0548 2.21 0.98 0.009 0.947 3.9e-05 786 PRS_PLINK_1.58489319246107e.102 TRUE 252.1 Hyperparathyroidism Both 2 21 3 endocrine/metabolic brown 21, 2 6, 0 5, 1 5, 0 5, 1 -0.0919 1.08 0.932 0.031 0.912 0.0407 1130 0.145 1.94 0.94 0.027 1.16 0.00436 51.9 -0.0548 2.21 0.98 0.009 0.947 3.9e-05 786 PRS_PLINK_1.58489319246107e.102 TRUE 252.2 Hypoparathyroidism Both 0 5 3 endocrine/metabolic brown 5, 0 2 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 253 Disorders of the pituitary gland and its hypothalamic control Both 2 14 3 endocrine/metabolic brown 14, 2 4, 1 3, 0 3, 1 4, 0 0.419 0.97 0.666 0.177 1.52 0.292 20.9 0.0175 25.7 0.999 0 1.02 0.907 0.814 0.222 2380 1 0 1.25 2.06 3.75 0.169 64.3 0.998 0.001 1.18 9.47e-05 1.39 PRS_PLINK_1.58489319246107e.102 TRUE 253.1 Pituitary hyperfunction Both 0 6 3 endocrine/metabolic brown 6, 0 2 1 1 2 PRS_PLINK_1.58489319246107e.102 TRUE 253.11 Acromegaly and gigantism Both 0 1 3 endocrine/metabolic brown 1, 0 PRS_PLINK_1.58489319246107e.102 TRUE 253.2 Pituitary hypofunction Both 1 7 3 endocrine/metabolic brown 7, 1 2, 1 2, 0 1, 0 2, 0 -0.00848 397 1 0 0.992 0.708 1.18 0.0214 1800 1 0 1.02 0.71 1.06 0.0241 1400 1 0 1.02 0.329 1.39 -0.0227 2790 1 0 0.978 0.482 1.97 PRS_PLINK_1.58489319246107e.102 TRUE 253.3 Diabetes insipidus Both 0 3 3 endocrine/metabolic brown 3, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 253.4 Anterior pituitary disorders Both 0 4 3 endocrine/metabolic brown 4, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 253.7 Other disorders of neurohypophysis Both 0 2 3 endocrine/metabolic brown 2, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 255 Disorders of adrenal glands Both 0 20 3 endocrine/metabolic brown 20, 0 5 5 5 5 PRS_PLINK_1.58489319246107e.102 TRUE 255.1 Adrenal hyperfunction Both 0 3 3 endocrine/metabolic brown 3, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 255.11 Cushing's syndrome Both 0 1 3 endocrine/metabolic brown 1, 0 PRS_PLINK_1.58489319246107e.102 TRUE 255.12 Hyperaldosteronism Both 0 1 3 endocrine/metabolic brown 1, 0 PRS_PLINK_1.58489319246107e.102 TRUE 255.2 Adrenal hypofunction Both 0 7 3 endocrine/metabolic brown 7, 0 2 2 1 2 PRS_PLINK_1.58489319246107e.102 TRUE 255.21 Glucocorticoid deficiency Both 0 7 3 endocrine/metabolic brown 7, 0 2 2 1 2 PRS_PLINK_1.58489319246107e.102 TRUE 256 Ovarian dysfunction Female 2 11 3 endocrine/metabolic brown 11, 2 3, 1 3, 0 2, 0 3, 1 0.0656 0.68 0.923 0.035 1.07 0.368 3.57 2.8 464 0.995 0.002 16.5 0.0126 7340 -0.00213 1770 1 0 0.998 0.412 1.35 0.992 885000 1 0 2.7 1.69 3.79 PRS_PLINK_1.58489319246107e.102 TRUE 256.4 Polycystic ovaries Female 1 6 3 endocrine/metabolic brown 6, 1 2, 0 1, 0 1, 0 2, 1 1.04 878 0.999 0 2.84 12.5 49.8 0.097 616 1 0 1.1 0.534 1.24 PRS_PLINK_1.58489319246107e.102 TRUE 257 Testicular dysfunction Male 5 10 3 endocrine/metabolic brown 10, 5 3, 4 2, 1 2, 0 3, 0 -0.826 1.37 0.547 0.262 0.438 0.00437 3.59 0.539 3.05 0.86 0.066 1.71 0.0112 314 0.469 720 0.999 0 1.6 0.201 6.81 0.0355 2.94 0.99 0.004 1.04 0.00556 113 PRS_PLINK_1.58489319246107e.102 TRUE 257.1 Testicular hypofunction Male 5 11 3 endocrine/metabolic brown 11, 5 3, 4 3, 1 2, 0 3, 0 -0.456 1.21 0.705 0.152 0.634 0.00446 35.4 1.12 2.59 0.664 0.178 3.08 0.0142 751 0.469 720 0.999 0 1.6 0.201 6.81 0.0355 2.94 0.99 0.004 1.04 0.00556 113 PRS_PLINK_1.58489319246107e.102 TRUE 258 Iatrogenic endocrine disorders Both 0 1 3 endocrine/metabolic brown 1, 0 PRS_PLINK_1.58489319246107e.102 TRUE 259 Other endocrine disorders Both 2 15 3 endocrine/metabolic brown 15, 2 4, 2 4, 0 3, 0 4, 0 -0.954 1.08 0.377 0.423 0.385 0.0222 2.32 0.0355 5280000 1 0 1.04 0.384 2.06 -0.0879 652 1 0 0.916 0.89 1.17 0.0186 2490 1 0 1.02 0.691 2.89 PRS_PLINK_1.58489319246107e.102 TRUE 260 Protein-calorie malnutrition Both 2 22 3 endocrine/metabolic brown 22, 2 5, 0 5, 1 5, 0 6, 1 0.373 0.769 0.627 0.203 1.45 0.33 28.6 1.6 2.97 0.59 0.229 4.96 0.0859 4070 1 3.09 0.746 0.127 2.73 0.0192 3650 PRS_PLINK_1.58489319246107e.102 TRUE 260.2 severe protein-calorie malnutrition Both 1 12 3 endocrine/metabolic brown 12, 1 3, 0 3, 0 3, 0 3, 1 0.447 1.28 0.726 0.139 1.56 0.141 44.6 0.133 1760 1 0 1.14 0.646 3.39 PRS_PLINK_1.58489319246107e.102 TRUE 260.22 Nutritional marasmus Both 1 4 3 endocrine/metabolic brown 4, 1 1, 0 1, 0 1, 0 1, 1 -0.0802 3550 1 0 0.923 0.199 2.08 0.00275 113 1 0 1 0.984 1.03 PRS_PLINK_1.58489319246107e.102 TRUE 260.3 Adult failure to thrive Both 1 3 3 endocrine/metabolic brown 3, 1 1, 0 1, 0 1, 1 1, 0 -0.0127 508 1 0 0.987 0.853 1.12 0.0884 4290 1 0 1.09 0.633 1.17 PRS_PLINK_1.58489319246107e.102 TRUE 260.6 Anorexia Both 1 4 3 endocrine/metabolic brown 4, 1 1, 0 1, 0 1, 0 1, 1 0.844 4.56e+08 1 0 2.32 8.07e-16 2.79e+12 -2.03 1.4e+09 1 0 0.131 3.04e-15 7.04e+10 PRS_PLINK_1.58489319246107e.102 TRUE 260.7 Polyphagia Both 0 2 3 endocrine/metabolic brown 2, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 261 Vitamin deficiency Both 20 37 3 endocrine/metabolic brown 37, 20 9, 8 9, 0 9, 6 9, 6 -0.282 0.312 0.366 0.436 0.755 0.412 1.32 -2.79 1.43 0.0507 1.295 0.0615 0.000253 0.582 -0.398 0.994 0.689 0.162 0.672 0.0873 3.81 -0.474 0.864 0.583 0.234 0.622 0.126 2.74 PRS_PLINK_1.58489319246107e.102 TRUE 261.1 Vitamin A deficiency Both 2 0 3 endocrine/metabolic brown 0, 2 PRS_PLINK_1.58489319246107e.102 TRUE 261.2 Vitamin B-complex deficiencies Both 1 7 3 endocrine/metabolic brown 7, 1 2, 0 2, 1 1, 0 2, 0 -0.407 56.4 0.994 0.003 0.666 0.107 22.2 0.00192 17.5 1 0 1 0.829 1.31 PRS_PLINK_1.58489319246107e.102 TRUE 261.4 Vitamin D deficiency Both 20 36 3 endocrine/metabolic brown 36, 20 8, 8 9, 0 9, 6 9, 6 -0.272 0.311 0.382 0.417 0.762 0.419 1.33 -3.42 1.63 0.0357 1.448 0.0328 9.72e-06 0.415 -0.817 1 0.416 0.381 0.442 0.051 2.43 -0.837 0.946 0.376 0.425 0.433 0.0669 2.16 PRS_PLINK_1.58489319246107e.102 TRUE 262 Mineral deficiency NEC Both 7 13 3 endocrine/metabolic brown 13, 7 4, 1 3, 3 3, 1 3, 2 0.478 0.996 0.631 0.2 1.61 0.231 131 -0.458 2.29 0.841 0.075 0.632 0.0197 17.8 2.92 1030 0.998 0.001 18.5 0.00479 2380000 -0.183 3420 1 0 0.833 0.181 1.8 PRS_PLINK_1.58489319246107e.102 TRUE 263 Other nutritional deficiency Both 4 19 3 endocrine/metabolic brown 19, 4 5, 1 5, 0 4, 1 5, 2 0.0895 0.951 0.925 0.034 1.09 0.226 10.9 0.0347 2.04 0.986 0.006 1.04 0.0599 26.6 -3.71 12 0.757 0.121 0.0244 8.11e-11 893000 0.756 2.5 0.762 0.118 2.13 0.0209 388 PRS_PLINK_1.58489319246107e.102 TRUE 264 Lack of normal physiological development Both 1 2 3 endocrine/metabolic brown 2, 1 1, 0 1, 1 1, 0 1, 1 0.0913 2630 1 0 1.1 0.0341 1.32 -0.00068 195 1 0 0.999 0.984 1.02 PRS_PLINK_1.58489319246107e.102 TRUE 264.2 Failure to thrive (childhood) Both 1 4 3 endocrine/metabolic brown 4, 1 1, 0 1, 0 1, 0 1, 1 -0.781 27300 1 0 0.458 0.000545 98.7 -0.00087 19.8 1 0 0.999 0.988 1.01 PRS_PLINK_1.58489319246107e.102 TRUE 264.9 Lack of normal physiological development, unspecified Both 1 1 3 endocrine/metabolic brown 1, 1 -0.00171 38.5 1 0 0.998 0.972 1.02 PRS_PLINK_1.58489319246107e.102 TRUE 269 Proteinuria Both 9 30 3 endocrine/metabolic brown 30, 9 7, 4 7, 0 7, 1 8, 4 0.053 0.446 0.905 0.043 1.05 0.479 2.39 -1.97 1.72 0.252 0.598 0.14 0.000792 2.89 0.403 2.07 0.846 0.073 1.5 0.0393 145 0.416 1.81 0.818 0.087 1.52 0.0451 72.5 PRS_PLINK_1.58489319246107e.102 TRUE 270 Disorders of protein plasma/amino-acid transport and metabolism Both 4 10 3 endocrine/metabolic brown 10, 4 3, 1 2, 1 2, 0 3, 2 0.106 1.7 0.95 0.022 1.11 0.0304 69.1 0.0875 391 1 0 1.09 0.779 1.62 -0.186 1660 1 0 0.83 4.49e-05 223 0.127 15.4 0.993 0.003 1.13 1.57 1.61 PRS_PLINK_1.58489319246107e.102 TRUE 270.1 Disturbances of amino-acid transport Both 1 1 3 endocrine/metabolic brown 1, 1 -0.00185 185 1 0 0.998 0.959 1.11 PRS_PLINK_1.58489319246107e.102 TRUE 270.11 Disturbances of sulphur-bearing amino-acid metabolism Both 1 0 3 endocrine/metabolic brown 0, 1 PRS_PLINK_1.58489319246107e.102 TRUE 270.2 Disorders of amino-acid metabolism Both 0 4 3 endocrine/metabolic brown 4, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 270.3 Disorders of plasma protein metabolism Both 3 10 3 endocrine/metabolic brown 10, 3 3, 1 2, 1 2, 0 3, 1 -0.446 1.85 0.809 0.092 0.64 0.0152 145 -0.00119 83.1 1 0 0.999 0.423 2.35 -0.186 1660 1 0 0.83 4.49e-05 223 0.119 1540 1 0 1.13 0.723 1.21 PRS_PLINK_1.58489319246107e.102 TRUE 270.32 Paraproteinemia Both 2 6 3 endocrine/metabolic brown 6, 2 2, 1 1, 1 1, 0 2, 0 -0.0337 238 1 0 0.967 0.52 1.47 -0.00102 737 1 0 0.999 0.612 1.6 0.0273 2740 1 0 1.03 0.407 2.68 0.0208 2270 1 0 1.02 0.496 2.16 PRS_PLINK_1.58489319246107e.102 TRUE 270.34 Alpha-1-antitrypsin deficiency Both 0 3 3 endocrine/metabolic brown 3, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 270.38 Other specified disorders of plasma protein metabolism Both 1 5 3 endocrine/metabolic brown 5, 1 2, 0 1, 0 1, 0 1, 1 3.59 18200000 1 0 36.2 9.03e-09 8.58e+09 0.0293 190 1 0 1.03 0.932 1.28 PRS_PLINK_1.58489319246107e.102 TRUE 271 Disorders of carbohydrate transport and metabolism Both 2 36 3 endocrine/metabolic brown 36, 2 9, 1 9, 1 9, 0 9, 0 -0.677 0.609 0.266 0.574 0.508 0.0295 1.71 0.33 1.52 0.829 0.082 1.39 0.027 58 0.635 1.97 0.747 0.127 1.89 0.00707 10700 -0.823 2.2 0.708 0.15 0.439 9.14e-06 264 PRS_PLINK_1.58489319246107e.102 TRUE 271.3 Intestinal disaccharidase deficiencies and disaccharide malabsorption Both 1 33 3 endocrine/metabolic brown 33, 1 9, 0 8, 1 8, 0 8, 0 -0.341 0.713 0.632 0.199 0.711 0.0492 4.64 0.469 1.61 0.77 0.113 1.6 0.035 83.5 PRS_PLINK_1.58489319246107e.102 TRUE 271.9 Other disorders of carbohydrate transport and metabolism Both 1 3 3 endocrine/metabolic brown 3, 1 1, 1 1, 0 1, 0 1, 1 0.127 474 1 0 1.14 0.822 2.28 0.00944 39.5 1 0 1.01 0.944 1.09 -0.012 87 1 0 0.988 0.914 1.3 PRS_PLINK_1.58489319246107e.102 TRUE 272 Disorders of lipoid metabolism Both 33 28 3 endocrine/metabolic brown 28, 33 7, 9 7, 6 7, 6 7, 11 -0.0661 0.345 0.848 0.072 0.936 0.485 1.79 -0.64 1.44 0.658 0.182 0.527 0.000199 6.59 -0.495 1.27 0.698 0.156 0.609 0.04 6.31 -0.0631 1.09 0.954 0.021 0.939 0.115 9.34 PRS_PLINK_1.58489319246107e.102 TRUE 272.1 Hyperlipidemia Both 33 28 3 endocrine/metabolic brown 28, 33 7, 9 7, 6 7, 6 7, 11 -0.0661 0.345 0.848 0.072 0.936 0.485 1.79 -0.64 1.44 0.658 0.182 0.527 0.000199 6.59 -0.495 1.27 0.698 0.156 0.609 0.04 6.31 -0.0631 1.09 0.954 0.021 0.939 0.115 9.34 PRS_PLINK_1.58489319246107e.102 TRUE 272.11 Hypercholesterolemia Both 16 19 3 endocrine/metabolic brown 19, 16 5, 4 5, 3 4, 2 5, 7 0.529 0.712 0.457 0.34 1.7 0.528 9.17 -0.0101 1.63 0.995 0.002 0.99 0.0255 131 -2.11 2.51 0.4 0.398 0.121 0.000202 7.99 3.2 2.53 0.206 0.685 24.5 0.437 25400 PRS_PLINK_1.58489319246107e.102 TRUE 272.12 Hyperglyceridemia Both 5 7 3 endocrine/metabolic brown 7, 5 2, 2 2, 0 1, 1 2, 2 -2.05 2.65 0.44 0.357 0.129 0.0012 4.77 -0.0509 2490 1 0 0.95 0.341 2.49 0.265 2430 1 0 1.3 0.717 1.41 -0.0101 76.1 1 0 0.99 0.00771 4.26 PRS_PLINK_1.58489319246107e.102 TRUE 272.13 Mixed hyperlipidemia Both 14 17 3 endocrine/metabolic brown 17, 14 5, 3 4, 4 4, 1 4, 6 0.328 0.767 0.669 0.175 1.39 0.267 6.75 0.488 1.59 0.759 0.12 1.63 0.0265 420 -2.48 4.38 0.572 0.243 0.0841 1.47e-06 98.4 0.753 1.64 0.646 0.19 2.12 0.0176 77.2 PRS_PLINK_1.58489319246107e.102 TRUE 272.9 Unspecified disorder of lipoid metabolism Both 0 3 3 endocrine/metabolic brown 3, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 274 Gout and other crystal arthropathies Both 2 27 3 endocrine/metabolic brown 27, 2 7, 1 7, 0 6, 0 7, 0 -0.764 0.635 0.229 0.64 0.466 0.0794 1.37 -0.209 1.69 0.902 0.045 0.811 0.0058 48.3 0.0485 2.61 0.985 0.006 1.05 0.00219 111 0.23 2.07 0.912 0.04 1.26 0.00537 78.8 PRS_PLINK_1.58489319246107e.102 TRUE 274.1 Gout Both 2 27 3 endocrine/metabolic brown 27, 2 7, 1 7, 0 6, 0 7, 0 -0.764 0.635 0.229 0.64 0.466 0.0794 1.37 -0.209 1.69 0.902 0.045 0.811 0.0058 48.3 0.0485 2.61 0.985 0.006 1.05 0.00219 111 0.23 2.07 0.912 0.04 1.26 0.00537 78.8 PRS_PLINK_1.58489319246107e.102 TRUE 274.11 Gouty arthropathy Both 1 21 3 endocrine/metabolic brown 21, 1 6, 0 5, 0 5, 0 5, 0 -0.643 0.895 0.473 0.326 0.526 0.0701 7.65 PRS_PLINK_1.58489319246107e.102 TRUE 274.2 Crystal arthropathies Both 0 2 3 endocrine/metabolic brown 2, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 274.21 Chondrocalcinosis Both 0 2 3 endocrine/metabolic brown 2, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 275 Disorders of mineral metabolism Both 7 47 3 endocrine/metabolic brown 47, 7 12, 2 12, 0 11, 1 12, 3 0.0365 0.423 0.931 0.031 1.04 0.461 2.47 -0.395 1.33 0.766 0.116 0.674 0.0174 102 0.0516 1.34 0.969 0.014 1.05 0.0368 87.8 0.606 1.24 0.624 0.205 1.83 0.173 169 PRS_PLINK_1.58489319246107e.102 TRUE 275.1 Disorders of iron metabolism Both 0 4 4 hematopoietic darkorange1 4, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 275.11 Hereditary hemochromatosis Both 0 3 4 hematopoietic darkorange1 3, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 275.2 Disorders of copper metabolism Both 0 2 3 endocrine/metabolic brown 2, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 275.3 Disorders of magnesium metabolism Both 2 19 3 endocrine/metabolic brown 19, 2 5, 0 5, 0 4, 0 5, 1 -0.276 0.802 0.731 0.136 0.759 0.115 3.26 0.811 3.23 0.802 0.096 2.25 0.0146 790 PRS_PLINK_1.58489319246107e.102 TRUE 275.5 Disorders of calcium/phosphorus metabolism Both 4 40 3 endocrine/metabolic brown 40, 4 10, 1 10, 0 10, 2 10, 1 1.08 0.835 0.196 0.709 2.95 0.611 46.3 -0.0659 1.3 0.96 0.018 0.936 0.0428 26.5 1.55 1.62 0.338 0.472 4.71 0.289 2450 0.409 1.59 0.797 0.098 1.5 0.0525 1180 PRS_PLINK_1.58489319246107e.102 TRUE 275.51 Hypocalcemia Both 0 9 3 endocrine/metabolic brown 9, 0 3 2 2 2 PRS_PLINK_1.58489319246107e.102 TRUE 275.53 Disorders of phosphorus metabolism Both 1 14 3 endocrine/metabolic brown 14, 1 4, 0 3, 0 3, 0 4, 1 0.0719 0.96 0.94 0.027 1.07 0.174 7.19 0.351 57.3 0.995 0.002 1.42 1.39 1.45 PRS_PLINK_1.58489319246107e.102 TRUE 275.6 Hypercalcemia Both 4 27 3 endocrine/metabolic brown 27, 4 7, 2 7, 0 6, 1 7, 1 0.795 0.889 0.371 0.431 2.21 0.422 90.9 -0.438 1.45 0.763 0.118 0.646 0.00222 9.71 0.998 2.19 0.649 0.188 2.71 0.00075 1480 0.18 1.72 0.917 0.038 1.2 0.00985 109 PRS_PLINK_1.58489319246107e.102 TRUE 276 Disorders of fluid, electrolyte, and acid-base balance Both 15 47 3 endocrine/metabolic brown 47, 15 11, 2 12, 3 11, 2 12, 8 0.585 0.386 0.129 0.888 1.8 0.9 4.17 1.1 1.24 0.374 0.427 3.01 0.36 177 -0.12 1.67 0.943 0.026 0.887 0.0378 72.1 1.47 1.18 0.212 0.674 4.36 0.572 105 PRS_PLINK_1.58489319246107e.102 TRUE 276.1 Electrolyte imbalance Both 11 40 3 endocrine/metabolic brown 40, 11 9, 2 10, 1 10, 2 10, 6 0.62 0.468 0.185 0.733 1.86 0.834 5.75 -0.104 1.42 0.942 0.026 0.901 0.0184 130 0.522 1.45 0.72 0.143 1.69 0.14 77 1.43 1.43 0.315 0.501 4.19 0.35 567 PRS_PLINK_1.58489319246107e.102 TRUE 276.11 Hyperosmolality and/or hypernatremia Both 0 7 3 endocrine/metabolic brown 7, 0 2 2 1 2 PRS_PLINK_1.58489319246107e.102 TRUE 276.12 Hyposmolality and/or hyponatremia Both 4 25 3 endocrine/metabolic brown 25, 4 6, 0 6, 0 6, 0 6, 4 0.534 0.702 0.447 0.35 1.71 0.416 39.6 1.21 2.1 0.565 0.248 3.35 0.155 35000 PRS_PLINK_1.58489319246107e.102 TRUE 276.13 Hyperpotassemia Both 3 27 3 endocrine/metabolic brown 27, 3 7, 2 7, 0 6, 0 7, 1 0.013 0.75 0.986 0.006 1.01 0.154 12.1 0.023 1.67 0.989 0.005 1.02 0.013 132 0.146 2.72 0.957 0.019 1.16 0.00923 3370 -0.314 1.99 0.874 0.058 0.73 0.00301 46.2 PRS_PLINK_1.58489319246107e.102 TRUE 276.14 Hypopotassemia Both 2 29 3 endocrine/metabolic brown 29, 2 7, 0 7, 0 7, 0 7, 2 0.297 0.626 0.636 0.197 1.35 0.374 12 1.15 1.84 0.533 0.273 3.14 0.139 2290 PRS_PLINK_1.58489319246107e.102 TRUE 276.4 Acid-base balance disorder Both 2 22 3 endocrine/metabolic brown 22, 2 6, 0 5, 1 5, 0 6, 1 -0.0812 0.764 0.915 0.038 0.922 0.112 4.8 1.11 2.29 0.628 0.202 3.03 0.114 45600 -0.157 1.81 0.931 0.031 0.855 0.0159 26.2 PRS_PLINK_1.58489319246107e.102 TRUE 276.41 Acidosis Both 2 20 3 endocrine/metabolic brown 20, 2 5, 0 5, 1 5, 0 5, 1 -0.0483 0.79 0.951 0.022 0.953 0.0883 5.03 1.05 2.22 0.638 0.195 2.85 0.119 414 0.0462 2.43 0.985 0.007 1.05 0.00891 178 PRS_PLINK_1.58489319246107e.102 TRUE 276.42 Alkalosis Both 0 6 3 endocrine/metabolic brown 6, 0 2 1 1 2 PRS_PLINK_1.58489319246107e.102 TRUE 276.5 Hypovolemia Both 6 39 3 endocrine/metabolic brown 39, 6 9, 0 10, 2 9, 2 10, 2 0.348 0.526 0.508 0.294 1.42 0.5 6.41 0.836 1.34 0.533 0.273 2.31 0.22 214 0.126 1.73 0.942 0.026 1.13 0.00276 134 0.536 1.23 0.664 0.178 1.71 0.203 266 PRS_PLINK_1.58489319246107e.102 TRUE 276.6 Fluid overload Both 0 16 3 endocrine/metabolic brown 16, 0 4 4 4 4 PRS_PLINK_1.58489319246107e.102 TRUE 276.8 Polydipsia Both 0 3 3 endocrine/metabolic brown 3, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 277 Other disorders of metabolism Both 9 43 3 endocrine/metabolic brown 43, 9 10, 2 11, 1 10, 3 11, 3 0.133 0.401 0.741 0.13 1.14 0.531 2.58 0.201 1.32 0.879 0.056 1.22 0.0424 79.4 0.734 1.16 0.528 0.278 2.08 0.251 47.4 0.25 1.31 0.849 0.071 1.28 0.0488 15100 PRS_PLINK_1.58489319246107e.102 TRUE 277.2 Other disorders of purine and pyrimidine metabolism Both 0 18 3 endocrine/metabolic brown 18, 0 5 4 4 5 PRS_PLINK_1.58489319246107e.102 TRUE 277.4 Disorders of bilirubin excretion Both 1 13 3 endocrine/metabolic brown 13, 1 4, 0 3, 1 3, 0 3, 0 -0.655 1.35 0.627 0.203 0.52 0.0164 3.71 -0.0619 233 1 0 0.94 0.796 1.06 PRS_PLINK_1.58489319246107e.102 TRUE 277.5 Other disorders of lipoid metabolism Both 2 21 3 endocrine/metabolic brown 21, 2 5, 0 5, 0 5, 1 5, 1 -0.0616 0.969 0.949 0.023 0.94 0.118 16.5 0.167 2.9 0.954 0.02 1.18 0.00509 160 -0.0522 1080 1 0 0.949 0.577 1.46 PRS_PLINK_1.58489319246107e.102 TRUE 277.51 Lipoprotein disorders Both 0 16 3 endocrine/metabolic brown 16, 0 4 4 4 4 PRS_PLINK_1.58489319246107e.102 TRUE 277.7 Dysmetabolic syndrome X Both 4 24 3 endocrine/metabolic brown 24, 4 5, 1 6, 0 6, 1 6, 2 0.183 0.724 0.8 0.097 1.2 0.314 16 -0.223 2.62 0.932 0.031 0.8 0.00607 2790 0.077 2.83 0.978 0.01 1.08 0.00605 2800 0.153 2.13 0.943 0.026 1.17 0.0169 601 PRS_PLINK_1.58489319246107e.102 TRUE 278 Overweight, obesity and other hyperalimentation Both 22 42 3 endocrine/metabolic brown 42, 22 10, 7 10, 2 10, 6 11, 7 -0.145 0.303 0.632 0.199 0.865 0.489 1.52 -2.17 1.33 0.104 0.982 0.114 0.00284 1.06 -1.59 1.29 0.219 0.66 0.203 0.0189 1.75 -1.13 0.942 0.229 0.64 0.322 0.0192 1.58 PRS_PLINK_1.58489319246107e.102 TRUE 278.1 Obesity Both 20 42 3 endocrine/metabolic brown 42, 20 10, 6 10, 2 10, 5 11, 7 -0.122 0.304 0.688 0.162 0.885 0.502 1.57 -2 1.34 0.135 0.87 0.135 0.00242 1.23 -1.62 1.28 0.203 0.691 0.197 0.000583 1.71 -0.776 0.979 0.428 0.369 0.46 0.0341 2.54 PRS_PLINK_1.58489319246107e.102 TRUE 278.11 Morbid obesity Both 6 38 3 endocrine/metabolic brown 38, 6 9, 0 9, 0 9, 1 10, 5 1.86 1.23 0.132 0.879 6.42 0.537 162000 0.255 2.25 0.91 0.041 1.29 0.00885 975 0.802 2.63 0.76 0.119 2.23 0.0158 5210 PRS_PLINK_1.58489319246107e.102 TRUE 278.3 Localized adiposity Both 0 8 3 endocrine/metabolic brown 8, 0 2 2 2 2 PRS_PLINK_1.58489319246107e.102 TRUE 278.4 Abnormal weight gain Both 2 36 3 endocrine/metabolic brown 36, 2 8, 2 9, 0 9, 0 9, 0 -1.23 0.967 0.205 0.688 0.294 5.54e-06 1.62 -2.12 1.71 0.216 0.665 0.12 0.00145 1.64 -1.19 1.83 0.517 0.286 0.305 8.34e-06 8.59 -3.27 2.32 0.158 0.801 0.0379 6.88e-06 1.25 PRS_PLINK_1.58489319246107e.102 TRUE 279 Disorders involving the immune mechanism Both 7 37 3 endocrine/metabolic brown 37, 7 9, 2 9, 0 9, 4 9, 1 -0.139 0.414 0.737 0.133 0.87 0.394 1.94 -1.17 1.44 0.416 0.381 0.31 0.00336 6.19 0.505 1.03 0.622 0.206 1.66 0.285 11.3 -1.24 1.53 0.417 0.38 0.288 0.00186 24.5 PRS_PLINK_1.58489319246107e.102 TRUE 279.1 Immunity deficiency Both 3 15 3 endocrine/metabolic brown 15, 3 4, 2 4, 1 3, 0 4, 0 -0.629 0.805 0.434 0.362 0.533 0.0729 2.92 0.358 16 0.982 0.008 1.43 1.28 1.59 -0.569 15400000 1 0 0.566 9.82e-06 3.8e+08 0.452 2.54 0.859 0.066 1.57 0.0642 1.73 PRS_PLINK_1.58489319246107e.102 TRUE 279.11 Deficiency of humoral immunity Both 2 6 3 endocrine/metabolic brown 6, 2 2, 2 1, 0 1, 0 2, 0 -0.69 285 0.998 0.001 0.502 0.331 1.23 -0.0787 411 1 0 0.924 0.0921 1.49 -0.0111 70.2 1 0 0.989 0.0819 13.8 0.201 5370000 1 0 1.22 0.0176 1150000 PRS_PLINK_1.58489319246107e.102 TRUE 279.2 Autoimmune disease NEC Both 3 12 3 endocrine/metabolic brown 12, 3 3, 1 3, 0 3, 1 3, 1 0.00467 1.19 0.997 0.001 1 0.116 194 0.101 829 1 0 1.11 0.383 3.28 -0.0185 990 1 0 0.982 0.396 1.17 0.109 2280 1 0 1.11 0.672 2.3 PRS_PLINK_1.58489319246107e.102 TRUE 279.7 Other immunological findings Both 12 42 3 endocrine/metabolic brown 42, 12 10, 3 10, 3 10, 4 11, 2 -0.103 0.329 0.755 0.122 0.902 0.49 1.66 0.638 1.22 0.601 0.221 1.89 0.213 109 0.67 0.998 0.502 0.299 1.95 0.361 12.6 -0.194 1.3 0.881 0.055 0.823 0.0476 11 PRS_PLINK_1.58489319246107e.102 TRUE 279.8 Other specified disorders involving the immune mechanism Both 3 9 3 endocrine/metabolic brown 9, 3 3, 1 2, 0 2, 2 2, 0 0.0343 1.06 0.974 0.011 1.03 0.128 7.97 0.0595 1610 1 0 1.06 0.341 3.64 -0.0944 228 1 0 0.91 0.226 2.38 0.33 1550 1 0 1.39 0.373 1.82 PRS_PLINK_1.58489319246107e.102 TRUE 280 Iron deficiency anemias Both 11 40 4 hematopoietic darkorange1 40, 11 10, 3 10, 1 10, 5 10, 2 0.00141 0.363 0.997 0.001 1 0.506 1.95 -0.708 1.32 0.591 0.229 0.492 0.0222 10.8 2.43 1.62 0.132 0.879 11.4 0.778 532 0.0344 1.15 0.976 0.011 1.04 0.112 8.86 PRS_PLINK_1.58489319246107e.102 TRUE 280.1 Iron deficiency anemias, unspecified or not due to blood loss Both 11 39 4 hematopoietic darkorange1 39, 11 10, 3 10, 1 9, 5 10, 2 0.00164 0.363 0.996 0.002 1 0.506 1.95 -0.708 1.32 0.591 0.229 0.492 0.0222 10.8 2.15 1.59 0.176 0.754 8.6 0.633 487 0.0344 1.15 0.976 0.011 1.04 0.112 8.86 PRS_PLINK_1.58489319246107e.102 TRUE 280.2 Iron deficiency anemia secondary to blood loss (chronic) Both 3 16 4 hematopoietic darkorange1 16, 3 4, 0 4, 2 4, 1 4, 0 0.0635 0.88 0.942 0.026 1.07 0.19 5.08 -2.78 437 0.995 0.002 0.0618 0.000115 11.7 -2.04 58.5 0.972 0.012 0.13 0.0992 0.171 PRS_PLINK_1.58489319246107e.102 TRUE 281 Other deficiency anemia Both 1 6 4 hematopoietic darkorange1 6, 1 2, 0 1, 1 1, 0 2, 0 -1.63 2170 0.999 0 0.195 0.000944 50.2 -0.214 8060 1 0 0.807 0.0199 7.78 PRS_PLINK_1.58489319246107e.102 TRUE 281.1 Megaloblastic anemia Both 0 4 4 hematopoietic darkorange1 4, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 281.11 Pernicious anemia Both 0 3 4 hematopoietic darkorange1 3, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 281.12 Other vitamin B12 deficiency anemia Both 0 3 4 hematopoietic darkorange1 3, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 281.9 Deficiency anemias Both 1 1 4 hematopoietic darkorange1 1, 1 0.0102 55.2 1 0 1.01 0.311 1.79 PRS_PLINK_1.58489319246107e.102 TRUE 282 Hereditary hemolytic anemias Both 1 5 4 hematopoietic darkorange1 5, 1 2, 0 1, 0 1, 1 1, 0 0.625 5730 1 0 1.87 0.0198 45.5 4.58 2.53e+09 1 0 97.5 2.42e-41 5.18e+37 PRS_PLINK_1.58489319246107e.102 TRUE 282.8 Other hemoglobinopathies Both 1 3 4 hematopoietic darkorange1 3, 1 1, 0 1, 0 1, 1 1, 0 1.14e-06 113000 1 0 1 3.51e-31 2540000 0.0115 7.64 0.999 0.001 1.01 0.909 1.18 PRS_PLINK_1.58489319246107e.102 TRUE 282.9 Other hereditary hemolytic anemias Both 1 2 4 hematopoietic darkorange1 2, 1 1, 1 1, 0 1, 1 1, 0 0.0156 498 1 0 1.02 0.577 1.53 -0.00177 75.9 1 0 0.998 0.96 1.04 PRS_PLINK_1.58489319246107e.102 TRUE 284 Aplastic anemia Both 1 7 4 hematopoietic darkorange1 7, 1 2, 0 2, 0 1, 0 2, 1 0.2 111 0.999 0.001 1.22 0.588 2.27 -0.0483 1100 1 0 0.953 0.665 2.06 PRS_PLINK_1.58489319246107e.102 TRUE 284.1 Pancytopenia Both 1 6 4 hematopoietic darkorange1 6, 1 2, 0 1, 0 1, 0 2, 1 -0.104 71.6 0.999 0.001 0.901 0.659 1.33 -0.0483 1100 1 0 0.953 0.665 2.06 PRS_PLINK_1.58489319246107e.102 TRUE 285 Other anemias Both 13 43 4 hematopoietic darkorange1 43, 13 11, 2 11, 4 10, 3 11, 3 -0.105 0.354 0.767 0.115 0.9 0.454 1.74 0.746 0.992 0.452 0.345 2.11 0.389 19.7 0.889 1.31 0.499 0.302 2.43 0.205 1250 0.14 1.21 0.908 0.042 1.15 0.0908 14.1 PRS_PLINK_1.58489319246107e.102 TRUE 285.1 Acute posthemorrhagic anemia Both 0 29 4 hematopoietic darkorange1 29, 0 8 7 7 7 PRS_PLINK_1.58489319246107e.102 TRUE 285.2 Anemia of chronic disease Both 1 23 4 hematopoietic darkorange1 23, 1 6, 0 6, 1 5, 0 6, 0 -0.533 0.867 0.538 0.269 0.587 0.0142 4.7 -0.596 2.77 0.829 0.081 0.551 9.27e-06 1550 PRS_PLINK_1.58489319246107e.102 TRUE 285.21 Anemia in chronic kidney disease Both 0 16 4 hematopoietic darkorange1 16, 0 4 4 4 4 PRS_PLINK_1.58489319246107e.102 TRUE 285.22 Anemia in neoplastic disease Both 0 5 4 hematopoietic darkorange1 5, 0 2 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 286 Coagulation defects Both 7 40 4 hematopoietic darkorange1 40, 7 9, 0 10, 1 10, 2 10, 4 0.941 0.658 0.152 0.817 2.56 0.765 28.4 -0.245 1.67 0.883 0.054 0.783 0.0376 56.7 0.249 1.47 0.866 0.063 1.28 0.000944 37.5 0.676 1.78 0.704 0.152 1.97 0.0653 271 PRS_PLINK_1.58489319246107e.102 TRUE 286.1 Congenital coagulation defects Both 0 8 4 hematopoietic darkorange1 8, 0 2 2 2 2 PRS_PLINK_1.58489319246107e.102 TRUE 286.11 Von willebrand's disease Both 0 3 4 hematopoietic darkorange1 3, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 286.12 Congenital deficiency of other clotting factors (including factor VII) Both 0 4 4 hematopoietic darkorange1 4, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 286.2 Encounter for long-term (current) use of anticoagulants Both 3 32 4 hematopoietic darkorange1 32, 3 7, 2 8, 0 8, 0 8, 1 -0.101 0.516 0.845 0.073 0.904 0.304 2.64 -2.74 2.09 0.19 0.722 0.0646 0.000135 2.38 -1.23 2.91 0.671 0.173 0.291 0.000298 39.2 -1.49 1.72 0.386 0.413 0.226 0.00158 3.31 PRS_PLINK_1.58489319246107e.102 TRUE 286.3 Coagulation defects complicating pregnancy or postpartum Female 1 2 4 hematopoietic darkorange1 2, 1 1, 0 1, 1 1, 0 1, 1 0.0565 1990 1 0 1.06 0.646 1.44 16.1 31300 1 0 9990000 2.28e-24 2.79e+43 PRS_PLINK_1.58489319246107e.102 TRUE 286.4 Acquired coagulation factor deficiency Both 0 3 4 hematopoietic darkorange1 3, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 286.5 Hemorrhagic disorder due to intrinsic circulating anticoagulants Both 0 4 4 hematopoietic darkorange1 4, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 286.6 Defibrination syndrome Both 5 37 4 hematopoietic darkorange1 37, 5 9, 0 9, 0 9, 2 9, 3 0.796 0.673 0.237 0.625 2.22 0.576 87.5 -0.211 1.85 0.909 0.042 0.809 0.00264 69.9 2.36 2.95 0.422 0.374 10.6 0.145 6790000 PRS_PLINK_1.58489319246107e.102 TRUE 286.7 Other and unspecified coagulation defects Both 6 40 4 hematopoietic darkorange1 40, 6 9, 0 10, 1 10, 2 10, 3 0.859 0.636 0.177 0.752 2.36 0.73 21 -0.0981 1.77 0.956 0.02 0.907 0.0348 370 0.284 1.61 0.86 0.066 1.33 0.000879 61.1 0.718 1.79 0.688 0.162 2.05 0.0817 199 PRS_PLINK_1.58489319246107e.102 TRUE 286.8 Hypercoagulable state Both 1 13 4 hematopoietic darkorange1 13, 1 4, 0 3, 0 3, 0 3, 1 0.0285 1.91 0.988 0.005 1.03 0.016 79 0.166 116 0.999 0 1.18 0.207 8.94 PRS_PLINK_1.58489319246107e.102 TRUE 286.81 Primary hypercoagulable state Both 1 11 4 hematopoietic darkorange1 11, 1 3, 0 3, 0 2, 0 3, 1 0.038 2.46 0.988 0.005 1.04 0.00449 77 0.36 1750 1 0 1.43 0.00071 13400 PRS_PLINK_1.58489319246107e.102 TRUE 286.9 Abnormal coagulation profile Both 2 14 4 hematopoietic darkorange1 14, 2 4, 0 3, 0 3, 0 4, 2 1.27 1.28 0.322 0.492 3.56 0.44 133 -0.0195 322 1 0 0.981 0.275 1.59 PRS_PLINK_1.58489319246107e.102 TRUE 287 Purpura and other hemorrhagic conditions Both 3 36 4 hematopoietic darkorange1 36, 3 9, 0 9, 0 9, 1 9, 2 0.414 0.7 0.555 0.256 1.51 0.258 69.4 0.27 1.83 0.883 0.054 1.31 0.0186 145 1.04 2.04 0.608 0.216 2.84 0.00437 522 PRS_PLINK_1.58489319246107e.102 TRUE 287.1 Spontaneous ecchymoses Both 0 3 4 hematopoietic darkorange1 3, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 287.3 Thrombocytopenia Both 3 33 4 hematopoietic darkorange1 33, 3 9, 0 8, 0 8, 1 8, 2 0.471 0.706 0.505 0.297 1.6 0.23 6330000 0.294 1.69 0.862 0.065 1.34 0.0271 155 0.901 1.68 0.591 0.228 2.46 0.0365 267 PRS_PLINK_1.58489319246107e.102 TRUE 287.31 Primary thrombocytopenia Both 1 5 4 hematopoietic darkorange1 5, 1 2, 0 1, 0 1, 0 1, 1 -0.0924 1320 1 0 0.912 0.525 1.52 0.792 22800 1 0 2.21 0.194 5.07 PRS_PLINK_1.58489319246107e.102 TRUE 287.32 Secondary thrombocytopenia Both 1 10 4 hematopoietic darkorange1 10, 1 3, 0 2, 0 2, 0 3, 1 2.83 6.91 0.682 0.166 17 14.5 20.1 0.00917 716 1 0 1.01 0.739 1.42 PRS_PLINK_1.58489319246107e.102 TRUE 287.4 Qualitative platelet defects Both 0 2 4 hematopoietic darkorange1 2, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 288 Diseases of white blood cells Both 7 51 4 hematopoietic darkorange1 51, 7 12, 2 13, 2 12, 1 13, 2 0.332 0.447 0.458 0.339 1.39 0.603 3.94 0.158 1.08 0.883 0.054 1.17 0.0815 19.8 0.354 1.19 0.767 0.115 1.42 0.126 32.8 0.243 1.54 0.875 0.058 1.28 0.0332 76900 PRS_PLINK_1.58489319246107e.102 TRUE 288.1 Decreased white blood cell count Both 2 19 4 hematopoietic darkorange1 19, 2 4, 0 5, 1 4, 1 5, 0 0.461 0.762 0.545 0.264 1.59 0.243 33.8 2.72 18 0.88 0.056 15.2 0.000379 18 -0.295 2730 1 0 0.745 0.00502 17.3 PRS_PLINK_1.58489319246107e.102 TRUE 288.11 Neutropenia Both 2 17 4 hematopoietic darkorange1 17, 2 4, 1 4, 0 4, 1 4, 0 0.122 0.746 0.87 0.061 1.13 0.305 33.4 -1.22 91.4 0.989 0.005 0.295 1.01e-06 85800 1.07e-14 4.61 1 0 1 0.00133 1150 -6.25e-12 99 1 0 1 1.81e-06 553000 PRS_PLINK_1.58489319246107e.102 TRUE 288.2 Elevated white blood cell count Both 5 47 4 hematopoietic darkorange1 47, 5 11, 2 12, 2 11, 0 12, 1 0.113 0.504 0.822 0.085 1.12 0.421 3.98 -0.159 1.1 0.886 0.053 0.853 0.0678 7.36 -0.271 1.5 0.857 0.067 0.762 0.00205 17.5 0.0761 1.41 0.957 0.019 1.08 0.0405 101 PRS_PLINK_1.58489319246107e.102 TRUE 288.3 Eosinophilia Both 2 0 4 hematopoietic darkorange1 0, 2 PRS_PLINK_1.58489319246107e.102 TRUE 289 Other diseases of blood and blood-forming organs Both 2 26 4 hematopoietic darkorange1 26, 2 6, 0 6, 0 6, 0 7, 2 0.452 0.655 0.49 0.31 1.57 0.406 193 0.221 2.66 0.934 0.03 1.25 0.0115 1480 PRS_PLINK_1.58489319246107e.102 TRUE 289.3 Personal history of diseases of blood and blood-forming organs Both 1 15 4 hematopoietic darkorange1 15, 1 4, 0 4, 0 3, 0 4, 1 0.581 0.934 0.534 0.273 1.79 0.461 55.5 -0.00801 1150 1 0 0.992 0.779 1.29 PRS_PLINK_1.58489319246107e.102 TRUE 289.4 Lymphadenitis Both 5 45 4 hematopoietic darkorange1 45, 5 11, 1 11, 1 11, 1 11, 2 0.0986 0.413 0.811 0.091 1.1 0.502 2.68 -0.0584 1.33 0.965 0.015 0.943 0.00998 16.4 0.504 1.55 0.745 0.128 1.66 0.0206 11000 -1.1 1.85 0.553 0.257 0.335 0.000163 32 PRS_PLINK_1.58489319246107e.102 TRUE 289.5 Diseases of spleen Both 0 5 4 hematopoietic darkorange1 5, 0 2 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 289.8 Polycythemia, secondary Both 1 9 4 hematopoietic darkorange1 9, 1 2, 0 2, 1 2, 0 2, 0 -0.0531 1500000 1 0 0.948 0.526 1.28 0.367 1860 1 0 1.44 0.721 1.61 PRS_PLINK_1.58489319246107e.102 TRUE 289.9 Abnormality of red blood cells Both 0 8 4 hematopoietic darkorange1 8, 0 2 2 2 2 PRS_PLINK_1.58489319246107e.102 TRUE 290 Delirium dementia and amnestic and other cognitive disorders Both 1 9 5 mental disorders magenta 9, 1 3, 0 2, 0 2, 0 2, 1 0.675 4.08 0.869 0.061 1.96 0.00366 1320 -0.123 2970 1 0 0.884 0.162 4.57 PRS_PLINK_1.58489319246107e.102 TRUE 290.1 Dementias Both 1 2 5 mental disorders magenta 2, 1 1, 0 1, 1 1, 0 1, 1 -0.219 9270 1 0 0.803 0.14 3.67 -0.0886 1820 1 0 0.915 0.456 1.26 PRS_PLINK_1.58489319246107e.102 TRUE 290.11 Alzheimer's disease Both 0 1 5 mental disorders magenta 1, 0 PRS_PLINK_1.58489319246107e.102 TRUE 290.13 Senile dementia Both 1 3 5 mental disorders magenta 3, 1 1, 0 1, 0 1, 1 1, 0 -0.255 5000 1 0 0.775 0.00529 4.46 -0.00294 31.1 1 0 0.997 0.948 1.09 PRS_PLINK_1.58489319246107e.102 TRUE 290.2 Delirium due to conditions classified elsewhere Both 0 5 5 mental disorders magenta 5, 0 2 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 290.3 Other persistent mental disorders due to conditions classified elsewhere Both 0 10 5 mental disorders magenta 10, 0 3 2 2 3 PRS_PLINK_1.58489319246107e.102 TRUE 291 Other specified nonpsychotic and/or transient mental disorders Both 2 36 5 mental disorders magenta 36, 2 8, 0 9, 0 9, 0 9, 2 0.636 0.623 0.307 0.512 1.89 0.457 16.7 0.295 2 0.883 0.054 1.34 0.0292 965 PRS_PLINK_1.58489319246107e.102 TRUE 291.1 Transient mental disorders due to conditions classified elsewhere Both 0 4 5 mental disorders magenta 4, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 291.4 Specific nonpsychotic mental disorders due to brain damage Both 0 9 5 mental disorders magenta 9, 0 3 2 2 2 PRS_PLINK_1.58489319246107e.102 TRUE 291.8 Alteration of consciousness Both 2 27 5 mental disorders magenta 27, 2 6, 0 7, 0 6, 1 7, 1 0.334 0.662 0.613 0.212 1.4 0.317 23 0.501 2.16 0.817 0.088 1.65 0.0418 102 -0.355 3.84 0.926 0.033 0.701 0.000173 5870 PRS_PLINK_1.58489319246107e.102 TRUE 292 Neurological disorders Both 8 51 5 mental disorders magenta 51, 8 12, 1 13, 2 12, 3 13, 2 0.145 0.435 0.739 0.131 1.16 0.465 3.05 -1.75 1.7 0.303 0.518 0.175 8.49e-05 5.03 0.326 1.1 0.767 0.115 1.39 0.157 14.2 -0.00029 1.18 1 0 1 0.08 9.44 PRS_PLINK_1.58489319246107e.102 TRUE 292.1 Aphasia/speech disturbance Both 3 20 5 mental disorders magenta 20, 3 5, 0 5, 1 5, 1 5, 1 -0.713 1.57 0.65 0.187 0.49 0.000649 69.9 0.763 2.92 0.794 0.1 2.14 5.08e-05 153 -1.44e-14 3.03 1 0 1 0.0123 147 0.839 4.71 0.859 0.066 2.31 0.000381 10900 PRS_PLINK_1.58489319246107e.102 TRUE 292.11 Aphasia Both 2 0 5 mental disorders magenta 0, 2 PRS_PLINK_1.58489319246107e.102 TRUE 292.12 Symbolic dysfunction Both 1 4 5 mental disorders magenta 4, 1 1, 1 1, 0 1, 0 1, 0 -1.55 1820 0.999 0 0.212 3.13e-06 5720 -0.504 3380 1 0 0.604 0.601 1.66 0.00762 49.4 1 0 1.01 0.972 1.16 0.0175 57.4 1 0 1.02 0.937 1.07 PRS_PLINK_1.58489319246107e.102 TRUE 292.2 Mild cognitive impairment Both 1 3 5 mental disorders magenta 3, 1 1, 1 1, 0 1, 0 1, 1 -0.37 13800 1 0 0.691 0.0234 11.5 0.00909 50 1 0 1.01 0.924 1.12 0.00748 38.4 1 0 1.01 0.916 1.11 PRS_PLINK_1.58489319246107e.102 TRUE 292.3 Memory loss Both 2 24 5 mental disorders magenta 24, 2 5, 0 6, 1 6, 0 6, 1 0.319 0.698 0.648 0.189 1.38 0.41 10.4 0.986 2.97 0.74 0.131 2.68 0.00764 863 0.604 3.89 0.876 0.057 1.83 0.00317 5540 PRS_PLINK_1.58489319246107e.102 TRUE 292.4 Altered mental status Both 3 28 5 mental disorders magenta 28, 3 6, 0 7, 1 7, 0 7, 2 -0.0593 0.598 0.921 0.036 0.942 0.308 4.5 -0.289 2.08 0.89 0.051 0.749 0.000646 9840 1.52 2.02 0.45 0.347 4.58 0.286 237000 PRS_PLINK_1.58489319246107e.102 TRUE 292.5 Transient alteration of awareness Both 0 7 5 mental disorders magenta 7, 0 1 2 1 2 PRS_PLINK_1.58489319246107e.102 TRUE 292.6 Hallucinations Both 0 2 5 mental disorders magenta 2, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 293 Symptoms involving head and neck Both 2 9 5 mental disorders magenta 9, 2 3, 0 2, 0 2, 0 2, 2 0.478 2.94 0.871 0.06 1.61 1.54 1.73 -0.0525 1780 1 0 0.949 0.441 3.9 PRS_PLINK_1.58489319246107e.102 TRUE 293.1 Swelling, mass, or lump in head and neck [Space-occupying lesion, intracranial NOS] Both 4 47 5 mental disorders magenta 47, 4 11, 1 12, 0 11, 2 12, 1 0.643 0.716 0.369 0.433 1.9 0.46 97.3 0.0428 1.24 0.972 0.012 1.04 0.0292 22.1 -0.00599 1.7 0.997 0.001 0.994 0.012 472 0.887 1.39 0.523 0.282 2.43 0.126 233 PRS_PLINK_1.58489319246107e.102 TRUE 295 Schizophrenia and other psychotic disorders Both 0 7 5 mental disorders magenta 7, 0 2 2 1 2 PRS_PLINK_1.58489319246107e.102 TRUE 295.1 Schizophrenia Both 0 1 5 mental disorders magenta 1, 0 PRS_PLINK_1.58489319246107e.102 TRUE 295.2 Paranoid disorders Both 0 3 5 mental disorders magenta 3, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 295.3 Psychosis Both 0 7 5 mental disorders magenta 7, 0 2 2 1 2 PRS_PLINK_1.58489319246107e.102 TRUE 296 Mood disorders Both 29 19 5 mental disorders magenta 19, 29 5, 4 5, 2 4, 7 5, 15 0.464 0.342 0.175 0.758 1.59 0.871 3.1 -0.313 2.54 0.902 0.045 0.731 0.000105 137000 1.83 2.03 0.368 0.434 6.23 0.205 1780 0.729 1.03 0.479 0.319 2.07 0.334 15.3 PRS_PLINK_1.58489319246107e.102 TRUE 296.1 Bipolar Both 2 13 5 mental disorders magenta 13, 2 4, 1 3, 0 3, 0 3, 1 0.0459 1.15 0.968 0.014 1.05 0.104 10.2 0.939 2330 1 0 2.56 5.4e-08 4270000 -0.132 136 0.999 0 0.877 0.39 1.93 -0.691 1540 1 0 0.501 0.103 0.18 PRS_PLINK_1.58489319246107e.102 TRUE 296.2 Depression Both 28 19 5 mental disorders magenta 19, 28 5, 4 5, 2 4, 7 5, 14 0.456 0.345 0.186 0.731 1.58 0.861 3.09 -0.313 2.54 0.902 0.045 0.731 0.000105 137000 1.83 2.03 0.368 0.434 6.23 0.205 1780 0.702 1.04 0.498 0.303 2.02 0.321 15 PRS_PLINK_1.58489319246107e.102 TRUE 296.22 Major depressive disorder Both 28 19 5 mental disorders magenta 19, 28 5, 4 5, 2 4, 7 5, 14 0.456 0.345 0.186 0.731 1.58 0.861 3.09 -0.313 2.54 0.902 0.045 0.731 0.000105 137000 1.83 2.03 0.368 0.434 6.23 0.205 1780 0.702 1.04 0.498 0.303 2.02 0.321 15 PRS_PLINK_1.58489319246107e.102 TRUE 297 Suicidal ideation or attempt Both 1 14 5 mental disorders magenta 14, 1 4, 0 3, 0 3, 0 4, 1 1.2 1.64 0.464 0.334 3.32 0.284 4500 -0.195 7.94 0.98 0.009 0.823 0.803 0.808 PRS_PLINK_1.58489319246107e.102 TRUE 297.1 Suicidal ideation Both 1 10 5 mental disorders magenta 10, 1 3, 0 2, 0 2, 0 3, 1 0.767 3.72 0.837 0.077 2.15 0.24 18.4 0.181 341 1 0 1.2 0.332 3.88 PRS_PLINK_1.58489319246107e.102 TRUE 297.2 Suicide or self-inflicted injury Both 0 7 5 mental disorders magenta 7, 0 2 2 1 2 PRS_PLINK_1.58489319246107e.102 TRUE 300 Anxiety disorders Both 25 19 5 mental disorders magenta 19, 25 5, 2 5, 3 4, 7 5, 12 0.458 0.42 0.276 0.559 1.58 0.748 3.71 0.465 2.33 0.841 0.075 1.59 0.0331 180000 0.554 1.58 0.727 0.139 1.74 0.0146 23600 1.2 1.6 0.454 0.343 3.32 0.236 341 PRS_PLINK_1.58489319246107e.102 TRUE 300.1 Anxiety disorder Both 24 19 5 mental disorders magenta 19, 24 5, 2 5, 2 4, 7 5, 12 0.455 0.417 0.274 0.562 1.58 0.753 3.67 0.436 2.31 0.85 0.07 1.55 0.0323 10900 0.554 1.58 0.727 0.139 1.74 0.0146 23600 1.2 1.6 0.454 0.343 3.32 0.236 341 PRS_PLINK_1.58489319246107e.102 TRUE 300.11 Generalized anxiety disorder Both 12 18 5 mental disorders magenta 18, 12 5, 2 4, 2 4, 3 5, 5 0.462 0.576 0.422 0.374 1.59 0.59 5.83 1.2 3.71 0.746 0.127 3.33 0.0087 829000 0.00946 2.53 0.997 0.001 1.01 4.97e-05 4160 -0.427 1.94 0.825 0.083 0.652 0.00988 33.8 PRS_PLINK_1.58489319246107e.102 TRUE 300.12 Agorophobia, social phobia, and panic disorder Both 2 15 5 mental disorders magenta 15, 2 4, 0 4, 0 3, 0 4, 2 0.661 1.42 0.643 0.192 1.94 0.0935 66.4 -4.99 12.4 0.688 0.162 0.0068 1.35e-11 183000 PRS_PLINK_1.58489319246107e.102 TRUE 300.13 Phobia Both 3 12 5 mental disorders magenta 12, 3 3, 0 3, 0 3, 0 3, 3 0.102 1.08 0.925 0.034 1.11 0.0937 8.71 -0.772 116 0.995 0.002 0.462 0.339 1.37 PRS_PLINK_1.58489319246107e.102 TRUE 300.3 Obsessive-compulsive disorders Both 0 6 5 mental disorders magenta 6, 0 2 1 1 2 PRS_PLINK_1.58489319246107e.102 TRUE 300.4 Dysthymic disorder Both 8 17 5 mental disorders magenta 17, 8 5, 1 4, 1 4, 3 4, 3 0.115 1.07 0.915 0.039 1.12 0.0867 14.7 -1.05 6.49 0.871 0.06 0.348 0.317 0.396 -0.585 4.34 0.893 0.049 0.557 0.00043 2170 2.09 3.51 0.552 0.258 8.09 0.0566 4.08e+08 PRS_PLINK_1.58489319246107e.102 TRUE 300.8 Acute reaction to stress Both 0 2 5 mental disorders magenta 2, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 300.9 Posttraumatic stress disorder Both 1 7 5 mental disorders magenta 7, 1 2, 0 2, 0 1, 0 2, 1 -0.378 4420000 1 0 0.685 0.298 1.35 0.0201 575 1 0 1.02 0.603 1.33 PRS_PLINK_1.58489319246107e.102 TRUE 301 Personality disorders Both 0 6 5 mental disorders magenta 6, 0 2 1 1 2 PRS_PLINK_1.58489319246107e.102 TRUE 301.2 Antisocial/borderline personality disorder Both 0 3 5 mental disorders magenta 3, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 302 Sexual and gender identity disorders Both 9 13 5 mental disorders magenta 13, 9 4, 4 3, 2 3, 1 3, 2 -0.591 0.795 0.457 0.34 0.554 0.0814 4.56 -0.691 1.76 0.695 0.158 0.501 0.0217 63.9 -0.87 2.69 0.746 0.127 0.419 0.366 4.13 -0.0776 2.52 0.975 0.011 0.925 0.0158 102 PRS_PLINK_1.58489319246107e.102 TRUE 302.1 Decreased libido Both 1 4 5 mental disorders magenta 4, 1 1, 1 1, 0 1, 0 1, 0 0.429 2550 1 0 1.54 0.186 10.1 -0.00998 147 1 0 0.99 0.853 1.17 0.00072 4.7 1 0 1 0.984 1.02 0.00611 48.5 1 0 1.01 0.981 1.06 PRS_PLINK_1.58489319246107e.102 TRUE 303 Psychogenic and somatoform disorders Both 8 16 5 mental disorders magenta 16, 8 4, 3 4, 1 4, 1 4, 3 0.218 0.83 0.793 0.101 1.24 0.286 88.5 0.142 3.06 0.963 0.016 1.15 0.00439 164 0.893 2.44 0.715 0.146 2.44 0.0652 504 -3.02 4.96 0.543 0.265 0.049 4.72e-06 234 PRS_PLINK_1.58489319246107e.102 TRUE 303.1 Dissociative disorder Both 0 5 5 mental disorders magenta 5, 0 2 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 303.3 Psychogenic disorder Both 8 16 5 mental disorders magenta 16, 8 4, 3 4, 1 4, 1 4, 3 0.218 0.83 0.793 0.101 1.24 0.286 88.5 0.142 3.06 0.963 0.016 1.15 0.00439 164 0.893 2.44 0.715 0.146 2.44 0.0652 504 -3.02 4.96 0.543 0.265 0.049 4.72e-06 234 PRS_PLINK_1.58489319246107e.102 TRUE 303.31 Gastrointestinal malfunction arising from mental factors Both 1 5 5 mental disorders magenta 5, 1 2, 0 1, 0 1, 1 1, 0 4.74 1810 0.998 0.001 115 1.7e-07 3.35e+12 0.689 3850 1 0 1.99 0.0583 14 PRS_PLINK_1.58489319246107e.102 TRUE 303.4 Somatoform disorder Both 0 13 5 mental disorders magenta 13, 0 4 3 3 3 PRS_PLINK_1.58489319246107e.102 TRUE 304 Adjustment reaction Both 10 18 5 mental disorders magenta 18, 10 5, 1 4, 0 4, 4 5, 5 0.0888 0.661 0.893 0.049 1.09 0.328 4.36 -2.23 7.63 0.77 0.114 0.107 0.00395 3.11 -0.00378 2.15 0.999 0.001 0.996 0.0226 14200 -1.13 3.93 0.773 0.112 0.322 9.49e-06 197 PRS_PLINK_1.58489319246107e.102 TRUE 305.2 Eating disorder Both 1 10 5 mental disorders magenta 10, 1 3, 0 2, 0 2, 0 3, 1 1.18 1.91 0.537 0.27 3.25 0.244 239 0.122 71.1 0.999 0.001 1.13 0.561 2 PRS_PLINK_1.58489319246107e.102 TRUE 306 Other mental disorder Both 6 14 5 mental disorders magenta 14, 6 4, 1 3, 0 3, 1 4, 4 0.68 1.13 0.548 0.261 1.97 0.201 19.5 0.0288 264 1 0 1.03 0.545 1.99 0.616 92.7 0.995 0.002 1.85 1.39 1.51 -0.059 2.76 0.983 0.007 0.943 0.000983 73200 PRS_PLINK_1.58489319246107e.102 TRUE 306.1 Mental disorders durring/after pregnancy Female 1 6 5 mental disorders magenta 6, 1 2, 0 1, 0 1, 1 2, 0 0.0497 431 1 0 1.05 1.15 0.824 -2.51 26700000 1 0 0.0815 4.65e-07 56000 PRS_PLINK_1.58489319246107e.102 TRUE 306.9 Tension headache Both 4 10 5 mental disorders magenta 10, 4 3, 0 2, 0 2, 1 3, 3 -0.461 1.71 0.787 0.104 0.631 0.00248 47.3 -0.0102 820 1 0 0.99 0.815 1.19 -0.836 282 0.998 0.001 0.433 0.00846 1200 PRS_PLINK_1.58489319246107e.102 TRUE 312 Conduct disorders Both 2 1 5 mental disorders magenta 1, 2 -0.00127 505 1 0 0.999 0.996 1.02 PRS_PLINK_1.58489319246107e.102 TRUE 312.3 Impulse control disorder Both 1 0 5 mental disorders magenta 0, 1 PRS_PLINK_1.58489319246107e.102 TRUE 313 Pervasive developmental disorders Both 3 28 5 mental disorders magenta 28, 3 6, 0 7, 0 7, 0 7, 3 0.363 0.679 0.592 0.227 1.44 0.384 63.4 0.501 2.33 0.829 0.081 1.65 0.00582 1150 PRS_PLINK_1.58489319246107e.102 TRUE 313.1 Attention deficit hyperactivity disorder Both 3 25 5 mental disorders magenta 25, 3 6, 0 6, 0 6, 0 6, 3 0.53 0.716 0.459 0.338 1.7 0.413 76.6 0.46 2.3 0.841 0.075 1.58 0.00689 788 PRS_PLINK_1.58489319246107e.102 TRUE 313.2 Tics and stuttering Both 0 1 5 mental disorders magenta 1, 0 PRS_PLINK_1.58489319246107e.102 TRUE 313.3 Autism Both 0 2 5 mental disorders magenta 2, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 315 Develomental delays and disorders Both 2 13 5 mental disorders magenta 13, 2 4, 0 3, 0 3, 1 3, 1 0.442 1.35 0.743 0.129 1.56 0.0723 28.8 -0.0287 82.7 1 0 0.972 0.42 1.24 -0.0941 7610000 1 0 0.91 0.0687 5.96 PRS_PLINK_1.58489319246107e.102 TRUE 315.1 Learning disorder Both 0 2 5 mental disorders magenta 2, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 315.2 Speech and language disorder Both 2 5 5 mental disorders magenta 5, 2 2, 0 1, 0 1, 0 1, 2 -0.114 78 0.999 0.001 0.892 0.539 2.01 -0.205 1550 1 0 0.815 0.362 1.62 PRS_PLINK_1.58489319246107e.102 TRUE 316 Substance addiction and disorders Both 3 49 5 mental disorders magenta 49, 3 12, 0 12, 2 12, 0 12, 1 -0.0243 0.478 0.959 0.018 0.976 0.257 3.64 0.588 1.23 0.633 0.198 1.8 0.166 98.8 -0.00487 1.37 0.997 0.001 0.995 0.0452 50.5 PRS_PLINK_1.58489319246107e.102 TRUE 316.1 Polyneuropathy due to drugs Both 0 4 5 mental disorders magenta 4, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 317 Alcohol-related disorders Both 0 36 5 mental disorders magenta 36, 0 8 9 9 9 PRS_PLINK_1.58489319246107e.102 TRUE 317.1 Alcoholism Both 0 29 5 mental disorders magenta 29, 0 7 7 7 7 PRS_PLINK_1.58489319246107e.102 TRUE 317.11 Alcoholic liver damage Both 0 7 5 mental disorders magenta 7, 0 2 2 1 2 PRS_PLINK_1.58489319246107e.102 TRUE 318 Tobacco use disorder Both 9 51 5 mental disorders magenta 51, 9 12, 1 13, 2 12, 1 13, 5 0.623 0.469 0.184 0.735 1.87 0.814 6.62 1 1.24 0.418 0.378 2.72 0.297 131 -1.03 1.72 0.55 0.259 0.358 0.00116 15.8 1.89 1.64 0.25 0.601 6.61 0.297 16100000 PRS_PLINK_1.58489319246107e.102 TRUE 320 Meningitis Both 1 3 6 neurological darkblue 3, 1 1, 0 1, 1 1, 0 1, 0 1.96 15700 1 0 7.09 1.5e-07 7.34e+11 -0.00871 33.3 1 0 0.991 0.94 1.03 PRS_PLINK_1.58489319246107e.102 TRUE 323 Encephalitis Both 1 1 6 neurological darkblue 1, 1 0.0119 66.1 1 0 1.01 0.21 1.26 PRS_PLINK_1.58489319246107e.102 TRUE 323.8 Encephalitis, non-infectious Both 1 1 6 neurological darkblue 1, 1 0.0119 66.1 1 0 1.01 0.21 1.26 PRS_PLINK_1.58489319246107e.102 TRUE 324 Other CNS infection and poliomyelitis Both 0 5 6 neurological darkblue 5, 0 2 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 327 Sleep disorders Both 24 38 6 neurological darkblue 38, 24 10, 8 9, 0 9, 8 10, 8 -0.0295 0.319 0.926 0.033 0.971 0.536 1.77 -2.36 1.42 0.0967 1.014 0.0948 0.000202 0.968 -0.345 0.907 0.703 0.153 0.708 0.139 3.38 0.322 0.847 0.704 0.153 1.38 0.308 6.8 PRS_PLINK_1.58489319246107e.102 TRUE 327.1 Hypersomnia Both 5 21 6 neurological darkblue 21, 5 6, 0 5, 0 5, 2 5, 3 1 0.946 0.289 0.54 2.73 0.58 32.5 0.206 1.99 0.918 0.037 1.23 0.0254 93.2 6.67 6.84 0.33 0.482 788 0.201 1180 PRS_PLINK_1.58489319246107e.102 TRUE 327.3 Sleep apnea Both 21 37 6 neurological darkblue 37, 21 10, 7 9, 0 9, 6 9, 7 -0.173 0.312 0.58 0.237 0.842 0.469 1.5 -2.33 1.49 0.118 0.93 0.0969 0.000221 1.05 0.000594 0.868 0.999 0 1 0.213 4.81 0.297 0.899 0.741 0.13 1.35 0.268 7.52 PRS_PLINK_1.58489319246107e.102 TRUE 327.31 Central/nonobstroctive sleep apnea Both 2 5 6 neurological darkblue 5, 2 2, 2 1, 0 1, 0 1, 0 0.00688 1670 1 0 1.01 0.724 1.46 -0.0394 411 1 0 0.961 0.381 1.16 0.103 2440 1 0 1.11 0.561 1.27 -0.0156 56.1 1 0 0.984 0.528 1.29 PRS_PLINK_1.58489319246107e.102 TRUE 327.32 Obstructive sleep apnea Both 18 35 6 neurological darkblue 35, 18 9, 6 9, 0 8, 6 9, 6 0.018 0.364 0.961 0.017 1.02 0.519 2.05 -2.2 1.46 0.133 0.877 0.111 0.000196 1.15 0.326 0.886 0.713 0.147 1.39 0.294 7.03 -0.307 1.04 0.769 0.114 0.736 0.0879 4.76 PRS_PLINK_1.58489319246107e.102 TRUE 327.4 Insomnia Both 10 35 6 neurological darkblue 35, 10 9, 3 9, 0 8, 4 9, 3 0.442 0.521 0.396 0.402 1.56 0.588 5.09 -0.972 1.51 0.52 0.284 0.378 0.0031 33.6 0.581 1.4 0.679 0.168 1.79 0.14 56.7 2.78 2.18 0.202 0.694 16.2 0.407 589000 PRS_PLINK_1.58489319246107e.102 TRUE 327.41 Organic or persistent insomnia Both 3 11 6 neurological darkblue 11, 3 3, 0 3, 1 2, 0 3, 2 0.41 1.12 0.714 0.146 1.51 0.291 26 0.122 1050 1 0 1.13 0.755 1.92 -0.46 4720 1 0 0.631 0.0373 2.82 PRS_PLINK_1.58489319246107e.102 TRUE 327.5 Parasomnia Both 3 9 6 neurological darkblue 9, 3 3, 0 2, 0 2, 0 2, 3 0.814 2.55 0.749 0.125 2.26 0.0373 245 0.00105 752 1 0 1 0.506 1.43 PRS_PLINK_1.58489319246107e.102 TRUE 327.6 Circadian rhythm sleep disorder Both 0 6 6 neurological darkblue 6, 0 2 1 1 2 PRS_PLINK_1.58489319246107e.102 TRUE 327.7 Sleep related movement disorders Both 3 21 6 neurological darkblue 21, 3 6, 1 5, 0 5, 0 5, 2 0.16 0.77 0.835 0.078 1.17 0.275 9.77 -0.234 2.22 0.916 0.038 0.792 0.00757 112 -1.31 2.67 0.625 0.204 0.271 0.00207 29.2 1.57 2.17 0.468 0.33 4.82 0.216 162000 PRS_PLINK_1.58489319246107e.102 TRUE 327.71 Restless legs syndrome Both 2 17 6 neurological darkblue 17, 2 5, 0 4, 0 4, 0 4, 2 0.424 0.854 0.62 0.208 1.53 0.322 46.1 -0.081 5.08 0.987 0.006 0.922 0.914 0.932 PRS_PLINK_1.58489319246107e.102 TRUE 327.72 Sleep related leg cramps Both 0 1 6 neurological darkblue 1, 0 PRS_PLINK_1.58489319246107e.102 TRUE 331 Other cerebral degenerations Both 2 7 6 neurological darkblue 7, 2 2, 0 2, 0 1, 0 2, 2 -0.619 29.3 0.983 0.007 0.538 0.113 2.73 0.44 5350 1 0 1.55 0.0169 1.74 PRS_PLINK_1.58489319246107e.102 TRUE 331.1 Hydrocephalus Both 0 1 6 neurological darkblue 1, 0 PRS_PLINK_1.58489319246107e.102 TRUE 331.9 Cerebral degeneration, unspecified Both 2 3 6 neurological darkblue 3, 2 1, 0 1, 0 1, 2 1, 0 0.0419 7590 1 0 1.04 0.0078 407 1.24e-05 10500 1 0 1 0.0793 11.9 PRS_PLINK_1.58489319246107e.102 TRUE 332 Parkinson's disease Both 0 1 6 neurological darkblue 1, 0 PRS_PLINK_1.58489319246107e.102 TRUE 333 Extrapyramidal disease and abnormal movement disorders Both 6 27 6 neurological darkblue 27, 6 6, 0 7, 0 6, 1 7, 5 0.98 0.659 0.137 0.863 2.66 0.838 29.8 0.504 1.8 0.78 0.108 1.65 0.0596 72.1 2.43 1.74 0.164 0.785 11.3 0.815 2480 PRS_PLINK_1.58489319246107e.102 TRUE 333.1 Essential tremor Both 1 6 6 neurological darkblue 6, 1 2, 0 1, 0 1, 0 2, 1 0.0437 960 1 0 1.04 1.12 1.41 -0.202 2980 1 0 0.817 0.0476 16.6 PRS_PLINK_1.58489319246107e.102 TRUE 333.2 Myoclonus Both 0 2 6 neurological darkblue 2, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 333.4 Torsion dystonia Both 0 4 6 neurological darkblue 4, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 333.8 Other degenerative diseases of the basal ganglia Both 1 1 6 neurological darkblue 1, 1 -0.0246 59.7 1 0 0.976 0.956 1.05 PRS_PLINK_1.58489319246107e.102 TRUE 334 Degenerative disease of the spinal cord Both 0 11 6 neurological darkblue 11, 0 3 3 2 3 PRS_PLINK_1.58489319246107e.102 TRUE 335 Multiple sclerosis Both 1 3 6 neurological darkblue 3, 1 1, 0 1, 0 1, 1 1, 0 0.0133 863 1 0 1.01 0.794 1.32 -0.00305 18.6 1 0 0.997 0.979 1.05 PRS_PLINK_1.58489319246107e.102 TRUE 337 Disorders of the autonomic nervous system Both 8 14 6 neurological darkblue 14, 8 3, 3 3, 0 3, 1 4, 4 0.504 0.744 0.498 0.303 1.66 0.364 9.43 -0.304 4.25 0.943 0.025 0.738 0.0889 0.63 0.105 1210 1 0 1.11 0.727 2.21 -0.925 4.49 0.837 0.077 0.396 7.95e-05 610 PRS_PLINK_1.58489319246107e.102 TRUE 337.1 Peripheral autonomic neuropathy Both 6 11 6 neurological darkblue 11, 6 3, 3 3, 0 2, 0 3, 3 -0.323 0.974 0.74 0.131 0.724 0.0384 4.11 -0.538 3.7 0.884 0.053 0.584 0.0014 420 -2.21 10.9 0.839 0.076 0.109 0.0976 0.121 0.438 3.94 0.912 0.04 1.55 7.77e-08 65300 PRS_PLINK_1.58489319246107e.102 TRUE 338 Pain Both 36 27 6 neurological darkblue 27, 36 7, 10 7, 5 6, 14 7, 6 -0.191 0.292 0.514 0.289 0.827 0.469 1.39 -0.463 0.95 0.626 0.203 0.629 0.0894 3.35 0.447 0.796 0.574 0.241 1.56 0.386 6.83 -0.115 1.06 0.914 0.039 0.892 0.123 6.65 PRS_PLINK_1.58489319246107e.102 TRUE 338.1 Acute pain Both 23 27 6 neurological darkblue 27, 23 7, 6 7, 3 6, 8 7, 5 -0.0796 0.322 0.805 0.094 0.924 0.504 1.64 -0.154 1.27 0.903 0.044 0.857 0.0474 8.56 0.387 0.919 0.673 0.172 1.47 0.315 7.33 -0.11 1.19 0.926 0.033 0.896 0.1 6.65 PRS_PLINK_1.58489319246107e.102 TRUE 338.2 Chronic pain Both 21 27 6 neurological darkblue 27, 21 7, 4 7, 2 6, 11 7, 4 0.0513 0.364 0.888 0.052 1.05 0.546 2.04 -0.538 1.17 0.645 0.19 0.584 0.0601 4.64 1.21 0.976 0.215 0.668 3.36 0.667 22.8 0.0228 1.66 0.989 0.005 1.02 0.0394 26.5 PRS_PLINK_1.58489319246107e.102 TRUE 339 Other headache syndromes Both 23 36 6 neurological darkblue 36, 23 9, 3 9, 5 9, 8 9, 6 0.361 0.33 0.275 0.561 1.43 0.797 2.77 0.604 1 0.547 0.262 1.83 0.322 14.5 0.508 1.07 0.635 0.197 1.66 0.176 14.1 0.665 1.31 0.613 0.212 1.94 0.162 29.1 PRS_PLINK_1.58489319246107e.102 TRUE 340 Migraine Both 19 35 6 neurological darkblue 35, 19 9, 3 9, 4 8, 6 9, 5 0.191 0.329 0.562 0.251 1.21 0.668 2.28 -0.399 1.45 0.783 0.106 0.671 0.00334 21 0.109 1.08 0.92 0.036 1.12 0.13 8.83 0.446 1.15 0.699 0.156 1.56 0.2 19.5 PRS_PLINK_1.58489319246107e.102 TRUE 340.1 Migrain with aura Both 8 25 6 neurological darkblue 25, 8 7, 3 6, 1 6, 3 6, 1 -0.113 0.495 0.819 0.087 0.893 0.365 2.31 -0.463 1.59 0.771 0.113 0.63 0.00497 8.01 0.00807 1.24 0.995 0.002 1.01 0.0736 8.28 -0.751 1.53 0.623 0.205 0.472 0.00735 7.34 PRS_PLINK_1.58489319246107e.102 TRUE 342 Hemiplegia Both 0 5 6 neurological darkblue 5, 0 2 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 343 Infantile cerebral palsy Both 0 1 6 neurological darkblue 1, 0 PRS_PLINK_1.58489319246107e.102 TRUE 344 Other paralytic syndromes Both 1 6 6 neurological darkblue 6, 1 2, 0 1, 0 1, 1 2, 0 -0.513 15700000 1 0 0.599 0.0196 7.92 -0.02 37.6 1 0 0.98 0.222 1.28 PRS_PLINK_1.58489319246107e.102 TRUE 345 Epilepsy, recurrent seizures, convulsions Both 5 34 6 neurological darkblue 34, 5 8, 0 8, 0 8, 0 9, 5 0.973 0.694 0.161 0.794 2.65 0.764 46.4 1.04 1.44 0.471 0.327 2.83 0.223 2090 PRS_PLINK_1.58489319246107e.102 TRUE 345.1 Epilepsy Both 1 13 6 neurological darkblue 13, 1 4, 0 3, 0 3, 0 3, 1 0.373 1.64 0.82 0.086 1.45 0.108 62.2 -0.0195 27.6 0.999 0 0.981 0.86 1.39 PRS_PLINK_1.58489319246107e.102 TRUE 345.11 Generalized convulsive epilepsy Both 1 3 6 neurological darkblue 3, 1 1, 0 1, 0 1, 1 1, 0 0.714 8180 1 0 2.04 0.000353 133000 -0.696 12100 1 0 0.499 0.195 4.75 PRS_PLINK_1.58489319246107e.102 TRUE 345.12 Partial epilepsy Both 1 6 6 neurological darkblue 6, 1 2, 0 1, 0 1, 0 2, 1 -0.11 354 1 0 0.896 0.486 1.19 -0.188 825 1 0 0.828 0.0271 10.1 PRS_PLINK_1.58489319246107e.102 TRUE 345.3 Convulsions Both 5 32 6 neurological darkblue 32, 5 7, 0 8, 0 8, 0 8, 5 0.925 0.671 0.168 0.774 2.52 0.763 24.3 5.28 3.97 0.183 0.737 197 0.42 4.78e+09 PRS_PLINK_1.58489319246107e.102 TRUE 346 Abnormal findings on study of brain and/or nervous system Both 0 5 6 neurological darkblue 5, 0 2 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 346.1 Nonspecific abnormal findings on radiological and other examination of skull and head Both 3 12 6 neurological darkblue 12, 3 3, 0 3, 0 3, 0 3, 3 0.458 0.955 0.632 0.199 1.58 0.374 18.1 3.84 141 0.978 0.01 46.4 41.5 880 PRS_PLINK_1.58489319246107e.102 TRUE 346.2 Nonspecific abnormal results of function study of brain and central nervous system Both 0 2 6 neurological darkblue 2, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 347 Cataplexy and narcolepsy Both 0 1 6 neurological darkblue 1, 0 PRS_PLINK_1.58489319246107e.102 TRUE 348 Other conditions of brain Both 2 17 6 neurological darkblue 17, 2 5, 0 4, 0 4, 1 4, 1 0.107 0.826 0.897 0.047 1.11 0.234 22.1 -3.21e-12 72.3 1 0 1 1.45e-08 1.33 -0.901 9.43 0.924 0.034 0.406 8.76e-07 407000 PRS_PLINK_1.58489319246107e.102 TRUE 348.2 Cerebral edema and compression of brain Both 1 10 6 neurological darkblue 10, 1 3, 0 2, 0 2, 0 3, 1 2.32 15 0.877 0.057 10.2 5.71e-14 5.89e+11 -0.23 2870 1 0 0.794 0.0563 11.7 PRS_PLINK_1.58489319246107e.102 TRUE 348.4 Cerebral cysts Both 0 4 6 neurological darkblue 4, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 348.7 Coma Both 0 2 6 neurological darkblue 2, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 348.8 Encephalopathy, not elsewhere classified Both 0 6 6 neurological darkblue 6, 0 2 1 1 2 PRS_PLINK_1.58489319246107e.102 TRUE 348.9 Other conditions of brain, NOS Both 3 20 6 neurological darkblue 20, 3 5, 1 5, 1 5, 1 5, 0 -0.969 1.05 0.354 0.451 0.38 5.78e-05 2.07 -1.41 2 0.483 0.316 0.245 0.00363 3.97 2.04 3.22 0.527 0.279 7.68 0.0843 1560 1.81 3.86 0.639 0.194 6.12 0.0341 3260 PRS_PLINK_1.58489319246107e.102 TRUE 349 Other and unspecified disorders of the nervous system Both 1 10 6 neurological darkblue 10, 1 3, 0 2, 0 2, 1 3, 0 -0.178 0.979 0.856 0.068 0.837 0.174 3.76 -0.849 16100000 1 0 0.428 2.07e-05 101000 PRS_PLINK_1.58489319246107e.102 TRUE 350 Abnormal movement Both 12 46 6 neurological darkblue 46, 12 11, 3 11, 1 11, 6 12, 2 -0.24 0.39 0.538 0.269 0.787 0.351 1.67 -1.76 1.45 0.227 0.645 0.173 0.000333 2.12 -0.306 1.04 0.767 0.115 0.736 0.108 4.64 -1.63 1.26 0.195 0.709 0.197 0.00709 1.74 PRS_PLINK_1.58489319246107e.102 TRUE 350.1 Abnormal involuntary movements Both 5 33 6 neurological darkblue 33, 5 8, 2 8, 1 8, 0 8, 2 -0.493 0.519 0.342 0.466 0.611 0.0109 1.63 -1.11 1.78 0.534 0.272 0.33 0.000214 5.82 -2.06 1.8 0.253 0.597 0.127 4.33e-05 1.96 -1.82 2.08 0.38 0.42 0.162 0.00194 5.15 PRS_PLINK_1.58489319246107e.102 TRUE 350.2 Abnormality of gait Both 8 28 6 neurological darkblue 28, 8 7, 0 7, 1 7, 4 7, 3 0.57 0.697 0.414 0.383 1.77 0.468 11.3 1.05 2.19 0.631 0.2 2.86 0.0271 391 0.784 1.86 0.673 0.172 2.19 0.0283 3450 0.565 2 0.778 0.109 1.76 0.0873 907 PRS_PLINK_1.58489319246107e.102 TRUE 350.3 Lack of coordination Both 3 12 6 neurological darkblue 12, 3 3, 2 3, 0 3, 1 3, 0 -2.27 1.97 0.249 0.603 0.103 5.97e-05 1.56 -0.345 441 0.999 0 0.708 0.294 0.493 -1.2 4.8 0.802 0.096 0.301 0.0911 0.234 -0.263 15.9 0.987 0.006 0.769 0.334 11.5 PRS_PLINK_1.58489319246107e.102 TRUE 350.5 Abnormal reflex Both 0 3 6 neurological darkblue 3, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 350.6 Disturbances of sensation of smell and taste Both 0 9 6 neurological darkblue 9, 0 3 2 2 2 PRS_PLINK_1.58489319246107e.102 TRUE 351 Other peripheral nerve disorders Both 18 39 6 neurological darkblue 39, 18 10, 5 10, 2 9, 9 10, 1 -0.364 0.347 0.295 0.531 0.695 0.353 1.32 -0.356 1.02 0.726 0.139 0.7 0.0932 4.76 1.24 1.11 0.26 0.584 3.47 0.461 45.2 -2.54 1.7 0.135 0.868 0.0787 0.000237 1.22 PRS_PLINK_1.58489319246107e.102 TRUE 352 Disorders of other cranial nerves Both 2 13 6 neurological darkblue 13, 2 4, 0 3, 0 3, 0 3, 2 -0.0121 1.36 0.993 0.003 0.988 0.0341 9.76 -1.41 19800000 1 0 0.244 6.1e-07 6.83e+09 PRS_PLINK_1.58489319246107e.102 TRUE 352.1 Trigeminal nerve disorders [CN5] Both 1 7 6 neurological darkblue 7, 1 2, 0 2, 0 1, 1 2, 0 0.21 986 1 0 1.23 0.426 2.58 0.0912 4080 1 0 1.1 0.43 765 PRS_PLINK_1.58489319246107e.102 TRUE 352.2 Facial nerve disorders [CN7] Both 1 5 6 neurological darkblue 5, 1 2, 0 1, 0 1, 0 1, 1 -0.0115 949 1 0 0.989 0.111 5.73 -0.0173 343 1 0 0.983 0.819 1.06 PRS_PLINK_1.58489319246107e.102 TRUE 353 Nerve root and plexus disorders Both 3 33 6 neurological darkblue 33, 3 9, 1 8, 0 8, 1 8, 1 0.138 0.491 0.779 0.108 1.15 0.439 3.66 -0.27 1.44 0.851 0.07 0.763 0.0213 24.2 0.108 1.67 0.949 0.023 1.11 0.061 50.8 0.447 1.45 0.759 0.12 1.56 0.0764 109 PRS_PLINK_1.58489319246107e.102 TRUE 353.1 Nerve plexus lesions Both 0 2 6 neurological darkblue 2, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 355 Complex regional/central pain syndrome Both 0 6 6 neurological darkblue 6, 0 2 1 1 2 PRS_PLINK_1.58489319246107e.102 TRUE 355.1 Chronic pain syndrome Both 0 11 6 neurological darkblue 11, 0 3 3 2 3 PRS_PLINK_1.58489319246107e.102 TRUE 356 Hereditary and idiopathic peripheral neuropathy Both 13 19 6 neurological darkblue 19, 13 5, 4 5, 1 4, 5 5, 2 -1.15 0.669 0.0864 1.063 0.317 0.0555 0.956 -1.05 1.36 0.441 0.356 0.35 0.0039 2.95 0.443 1.95 0.821 0.086 1.56 0.00485 210 -2.56 2.26 0.257 0.59 0.0774 7.34e-10 2.44 PRS_PLINK_1.58489319246107e.102 TRUE 357 Inflammatory and toxic neuropathy Both 14 23 6 neurological darkblue 23, 14 6, 5 6, 2 5, 5 6, 1 -1.2 0.678 0.0775 1.11 0.302 0.0591 0.931 -3.43 2.56 0.181 0.742 0.0325 3.05e-06 2.58 0.93 1.94 0.632 0.199 2.54 0.0549 825 -2.15 2.18 0.323 0.49 0.116 8.62e-10 4.01 PRS_PLINK_1.58489319246107e.102 TRUE 358 Myoneural disorders Both 3 5 6 neurological darkblue 5, 3 2, 0 1, 1 1, 0 1, 1 0.37 433 0.999 0 1.45 0.427 1.16 -0.278 7310 1 0 0.757 0.102 5.05 -0.212 6630 1 0 0.809 0.407 2.15 PRS_PLINK_1.58489319246107e.102 TRUE 359 Muscular dystrophies and other myopathies Both 5 12 6 neurological darkblue 12, 5 3, 1 3, 0 3, 1 3, 3 -0.226 1.17 0.846 0.073 0.798 0.0481 16.8 -0.259 2440 1 0 0.772 0.608 1.75 0.0279 86 1 0 1.03 0.809 1.36 -0.868 54.3 0.987 0.006 0.42 1.95e-07 0.527 PRS_PLINK_1.58489319246107e.102 TRUE 359.2 Myopathy Both 5 10 6 neurological darkblue 10, 5 3, 1 2, 0 2, 1 3, 3 0.315 1.59 0.843 0.074 1.37 0.0257 39.5 -0.243 3210 1 0 0.784 0.0999 2.21 -0.000127 559 1 0 1 0.811 1.25 -0.971 53 0.985 0.006 0.379 7.3e-07 0.463 PRS_PLINK_1.58489319246107e.102 TRUE 360.2 Progressive myopia Both 0 1 7 sense organs darkseagreen4 1, 0 PRS_PLINK_1.58489319246107e.102 TRUE 361 Retinal detachments and defects Both 0 10 7 sense organs darkseagreen4 10, 0 3 2 2 3 PRS_PLINK_1.58489319246107e.102 TRUE 361.1 Retinal detachment with retinal defect Both 0 6 7 sense organs darkseagreen4 6, 0 2 1 1 2 PRS_PLINK_1.58489319246107e.102 TRUE 362 Other retinal disorders Both 11 16 7 sense organs darkseagreen4 16, 11 4, 5 4, 1 4, 2 4, 3 -0.0712 0.576 0.902 0.045 0.931 0.316 2.66 -0.35 2.73 0.898 0.047 0.705 0.000477 72.5 0.335 2.51 0.894 0.049 1.4 0.0254 189 -0.64 1.7 0.707 0.15 0.527 0.00169 9.08 PRS_PLINK_1.58489319246107e.102 TRUE 362.2 Degeneration of macula and posterior pole of retina Both 3 10 7 sense organs darkseagreen4 10, 3 3, 1 2, 1 2, 0 3, 1 0.12 0.911 0.896 0.048 1.13 0.264 13.4 -0.0473 185 1 0 0.954 0.512 1.54 -6.28 1510 0.997 0.001 0.00187 1.77e-14 6.2e+10 2.44 11800000 1 0 11.5 3.38e-17 2.5e+15 PRS_PLINK_1.58489319246107e.102 TRUE 362.21 Macular degeneration, dry Both 0 2 7 sense organs darkseagreen4 2, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 362.22 Macular degeneration, wet Both 0 1 7 sense organs darkseagreen4 1, 0 PRS_PLINK_1.58489319246107e.102 TRUE 362.23 Cystoid macular degeneration of retina Both 0 4 7 sense organs darkseagreen4 4, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 362.26 Macular puckering of retina Both 2 7 7 sense organs darkseagreen4 7, 2 2, 1 2, 0 1, 0 2, 1 -0.0976 367 1 0 0.907 0.378 1.29 -1.08 21800 1 0 0.339 6.84e-06 83300 0.0702 8570 1 0 1.07 0.0198 89.1 4.72 54800000 1 0 112 1.78e-11 1.03e+16 PRS_PLINK_1.58489319246107e.102 TRUE 362.27 Drusen (degenerative) of retina Both 1 3 7 sense organs darkseagreen4 3, 1 1, 0 1, 1 1, 0 1, 0 -0.1 650 1 0 0.905 0.564 1.27 -0.172 4520 1 0 0.842 0.837 1.47 PRS_PLINK_1.58489319246107e.102 TRUE 362.29 Macular degeneration (senile) of retina NOS Both 3 10 7 sense organs darkseagreen4 10, 3 3, 1 2, 1 2, 0 3, 1 0.12 0.911 0.896 0.048 1.13 0.264 13.4 -0.0473 185 1 0 0.954 0.512 1.54 -6.28 1510 0.997 0.001 0.00187 1.77e-14 6.2e+10 2.44 11800000 1 0 11.5 3.38e-17 2.5e+15 PRS_PLINK_1.58489319246107e.102 TRUE 362.3 Other nondiabetic retinopathy Both 3 9 7 sense organs darkseagreen4 9, 3 3, 1 2, 2 2, 0 2, 0 -0.543 1.67 0.744 0.128 0.581 0.0404 6.72 -0.25 1350 1 0 0.779 0.562 1.42 -0.31 5170 1 0 0.733 0.509 5.1 -0.488 3110 1 0 0.614 0.0425 1.89 PRS_PLINK_1.58489319246107e.102 TRUE 362.31 Separation of retinal layers Both 0 4 7 sense organs darkseagreen4 4, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 362.4 Retinal vascular changes and abnomalities Both 4 3 7 sense organs darkseagreen4 3, 4 1, 0 1, 2 0, 1 1, 1 -0.0273 785 1 0 0.973 0.374 1.25 0.458 444000 1 0 1.58 0.00247 1010 -0.0103 64.8 1 0 0.99 0.847 5.7 0.152 17700 1 0 1.16 0.556 2.07 PRS_PLINK_1.58489319246107e.102 TRUE 362.6 Peripheral retinal degenerations Both 2 4 7 sense organs darkseagreen4 4, 2 1, 0 1, 0 1, 1 1, 1 0.15 325 1 0 1.16 0.799 2.34 -0.00723 17.1 1 0 0.993 0.821 1.06 -0.00948 81.3 1 0 0.991 0.874 1.04 PRS_PLINK_1.58489319246107e.102 TRUE 362.7 Hereditary retinal dystrophies Both 1 0 7 sense organs darkseagreen4 0, 1 PRS_PLINK_1.58489319246107e.102 TRUE 362.8 Retinal hemorrhage/ischemia Both 0 2 7 sense organs darkseagreen4 2, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 362.9 Retinal edema Both 1 4 7 sense organs darkseagreen4 4, 1 1, 0 1, 0 1, 0 1, 1 0.0278 1990 1 0 1.03 0.71 1.57 0.0561 4900000 1 0 1.06 0.6 1.58 PRS_PLINK_1.58489319246107e.102 TRUE 363 Chorioretinal inflammations, scars, and other disorders of choroid Both 0 7 7 sense organs darkseagreen4 7, 0 2 2 1 2 PRS_PLINK_1.58489319246107e.102 TRUE 363.3 Chorioretinal scars Both 0 5 7 sense organs darkseagreen4 5, 0 2 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 364 Corneal opacity and other disorders of cornea Both 4 15 7 sense organs darkseagreen4 15, 4 4, 1 4, 1 3, 1 4, 1 0.505 1.09 0.643 0.192 1.66 0.187 33 1.03 22 0.963 0.017 2.8 4.85e-05 167000 -0.718 66.1 0.991 0.004 0.488 0.000375 233 0.0968 42.9 0.998 0.001 1.1 5.97e-07 1.08 PRS_PLINK_1.58489319246107e.102 TRUE 364.1 Corneal opacity Both 2 8 7 sense organs darkseagreen4 8, 2 2, 0 2, 0 2, 0 2, 2 0.404 1.93 0.834 0.079 1.5 0.091 32.9 -0.425 1500 1 0 0.654 0.0766 4.12 PRS_PLINK_1.58489319246107e.102 TRUE 364.2 Corneal edema Both 1 2 7 sense organs darkseagreen4 2, 1 1, 0 1, 1 1, 0 1, 1 0.0859 1320 1 0 1.09 0.0352 4.33 0.108 1830 1 0 1.11 0.0138 32.6 PRS_PLINK_1.58489319246107e.102 TRUE 364.4 Corneal degenerations Both 3 5 7 sense organs darkseagreen4 5, 3 2, 1 1, 1 1, 0 1, 1 0.0876 14.6 0.995 0.002 1.09 0.0544 1.14 0.178 839 1 0 1.2 0.59 6.44 -2.68 37500 1 0 0.0684 3.14e-10 1760000 -0.0805 1680000 1 0 0.923 0.171 15.2 PRS_PLINK_1.58489319246107e.102 TRUE 364.5 Corneal dystrophy Both 1 4 7 sense organs darkseagreen4 4, 1 1, 0 1, 1 1, 0 1, 0 0.0763 4330 1 0 1.08 0.721 2.36 -0.0216 40.7 1 0 0.979 0.897 1.09 PRS_PLINK_1.58489319246107e.102 TRUE 365 Glaucoma Both 10 23 7 sense organs darkseagreen4 23, 10 6, 3 6, 1 5, 1 6, 5 0.495 0.641 0.44 0.357 1.64 0.554 6.42 -1 1.57 0.524 0.281 0.367 0.00761 5.32 -1.03 3.38 0.761 0.119 0.357 0.000106 301 0.846 1.29 0.512 0.291 2.33 0.283 365 PRS_PLINK_1.58489319246107e.102 TRUE 365.1 Open-angle glaucoma Both 3 6 7 sense organs darkseagreen4 6, 3 2, 0 1, 1 1, 0 2, 2 2.11 15.7 0.893 0.049 8.22 10.2 33.1 -0.0459 10500 1 0 0.955 0.0121 1.31 0.0163 474 1 0 1.02 0.811 1.58 PRS_PLINK_1.58489319246107e.102 TRUE 365.11 Primary open angle glaucoma Both 1 3 7 sense organs darkseagreen4 3, 1 1, 0 1, 0 1, 1 1, 0 -0.0113 1410 1 0 0.989 0.854 1.29 0.0304 2380000 1 0 1.03 0.269 2.95 PRS_PLINK_1.58489319246107e.102 TRUE 365.2 Primary angle-closure glaucoma Both 0 2 7 sense organs darkseagreen4 2, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 366 Cataract Both 22 22 7 sense organs darkseagreen4 22, 22 6, 7 5, 2 5, 8 6, 5 -0.0306 0.543 0.955 0.02 0.97 0.317 2.83 -0.376 1.34 0.779 0.109 0.687 0.0378 23.9 0.595 1.19 0.617 0.209 1.81 0.212 18.7 0.217 1.25 0.863 0.064 1.24 0.105 13.8 PRS_PLINK_1.58489319246107e.102 TRUE 366.1 Nonsenile Cataract Both 2 0 7 sense organs darkseagreen4 0, 2 PRS_PLINK_1.58489319246107e.102 TRUE 366.2 Senile cataract Both 19 18 7 sense organs darkseagreen4 18, 19 5, 6 4, 2 4, 5 5, 6 -0.62 0.791 0.433 0.363 0.538 0.0685 2.22 -0.615 1.5 0.681 0.167 0.541 0.00308 23.5 0.0999 1.99 0.96 0.018 1.11 0.018 28 -0.199 1.3 0.879 0.056 0.82 0.00196 7.36 PRS_PLINK_1.58489319246107e.102 TRUE 367 Disorders of refraction and accommodation; blindness and low vision Both 25 39 7 sense organs darkseagreen4 39, 25 9, 4 10, 6 9, 7 10, 8 0.232 0.321 0.469 0.328 1.26 0.701 2.38 0.322 0.955 0.736 0.133 1.38 0.257 8.19 1.55 1.36 0.251 0.6 4.74 0.477 161 0.339 1.06 0.749 0.125 1.4 0.213 11.4 PRS_PLINK_1.58489319246107e.102 TRUE 367.1 Myopia Both 22 36 7 sense organs darkseagreen4 36, 22 8, 4 9, 3 9, 7 9, 8 0.23 0.334 0.491 0.309 1.26 0.683 2.47 -0.101 1.01 0.92 0.036 0.904 0.143 5.39 0.815 1.15 0.479 0.32 2.26 0.327 30.8 0.324 1.07 0.761 0.118 1.38 0.212 11.2 PRS_PLINK_1.58489319246107e.102 TRUE 367.2 Astigmatism Both 12 32 7 sense organs darkseagreen4 32, 12 7, 4 8, 1 8, 5 8, 2 -0.039 0.369 0.916 0.038 0.962 0.477 2 -0.395 1.27 0.756 0.122 0.674 0.0608 5.67 0.0222 1.2 0.985 0.006 1.02 0.113 15.9 0.1 1.29 0.938 0.028 1.11 0.0802 41.3 PRS_PLINK_1.58489319246107e.102 TRUE 367.8 Hypermetropia Both 0 17 7 sense organs darkseagreen4 17, 0 5 4 4 4 PRS_PLINK_1.58489319246107e.102 TRUE 367.9 Blindness and low vision Both 3 14 7 sense organs darkseagreen4 14, 3 3, 0 3, 1 3, 0 4, 2 -0.716 1.27 0.574 0.241 0.489 0.000118 4.38 0.3 4550000 1 0 1.35 0.464 5.2 -0.165 1510 1 0 0.848 0.294 1.6 PRS_PLINK_1.58489319246107e.102 TRUE 368 Visual disturbances Both 15 46 7 sense organs darkseagreen4 46, 15 11, 5 11, 3 11, 3 12, 4 -0.04 0.348 0.909 0.042 0.961 0.497 1.92 -0.316 1.04 0.761 0.119 0.729 0.0548 5.23 -0.73 0.985 0.459 0.338 0.482 0.0622 2.58 -0.532 1.13 0.638 0.195 0.587 0.0561 4.57 PRS_PLINK_1.58489319246107e.102 TRUE 368.1 Amblyopia Both 2 11 7 sense organs darkseagreen4 11, 2 3, 2 3, 0 2, 0 3, 0 -0.202 2.6 0.938 0.028 0.817 0.000807 2440 -0.17 340 1 0 0.843 0.33 1.61 0.221 3100 1 0 1.25 0.613 1.73 -0.248 3250 1 0 0.781 0.0953 1.83 PRS_PLINK_1.58489319246107e.102 TRUE 368.2 Diplopia and disorders of binocular vision Both 7 13 7 sense organs darkseagreen4 13, 7 4, 5 3, 0 3, 1 3, 1 -0.707 0.854 0.408 0.39 0.493 0.0877 2.04 -1.61 2.45 0.511 0.291 0.2 9.37e-05 5.81 -3.66 2.99 0.221 0.656 0.0257 4.09e-09 1.4 -1.61 2.2 0.465 0.333 0.2 0.146 3.65 PRS_PLINK_1.58489319246107e.102 TRUE 368.3 Anisometropia Both 0 3 7 sense organs darkseagreen4 3, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 368.4 Visual field defects Both 3 12 7 sense organs darkseagreen4 12, 3 3, 2 3, 0 3, 0 3, 1 0.0911 1.43 0.949 0.023 1.1 0.0695 14.8 -0.369 7490000 1 0 0.692 0.242 3.7 0.325 263 0.999 0 1.38 0.224 17.3 0.951 16.6 0.954 0.02 2.59 1.45 4.99 PRS_PLINK_1.58489319246107e.102 TRUE 368.9 Subjective visual disturbances Both 3 11 7 sense organs darkseagreen4 11, 3 2, 1 3, 2 2, 0 3, 0 -0.0441 0.943 0.963 0.017 0.957 0.132 20.4 0.388 3740 1 0 1.47 0.26 1.9 -0.0639 677 1 0 0.938 0.424 1.31 -0.109 900 1 0 0.897 0.594 1.26 PRS_PLINK_1.58489319246107e.102 TRUE 368.91 Psychophysical visual disturbances Both 0 1 7 sense organs darkseagreen4 1, 0 PRS_PLINK_1.58489319246107e.102 TRUE 369 Infection of the eye Both 8 38 7 sense organs darkseagreen4 38, 8 9, 2 9, 2 9, 4 10, 0 0.271 0.503 0.591 0.229 1.31 0.482 4.06 1.26 1.37 0.359 0.445 3.51 0.359 3790 -0.624 1.47 0.671 0.173 0.536 0.00239 7.06 0.132 1.65 0.936 0.029 1.14 0.0285 110 PRS_PLINK_1.58489319246107e.102 TRUE 369.2 Eye infection, viral Both 1 11 7 sense organs darkseagreen4 11, 1 3, 1 3, 0 2, 0 3, 0 0.535 6.35 0.933 0.03 1.71 0.0146 234 0.0652 445 1 0 1.07 0.819 1.84 0.0435 2200 1 0 1.04 0.575 1.77 0.0477 723 1 0 1.05 0.831 1.38 PRS_PLINK_1.58489319246107e.102 TRUE 369.5 Conjunctivitis, infectious Both 6 32 7 sense organs darkseagreen4 32, 6 7, 2 8, 1 8, 3 8, 0 0.219 0.543 0.686 0.163 1.25 0.455 4.94 0.42 1.64 0.798 0.098 1.52 0.0831 3270 0.747 1.64 0.649 0.188 2.11 0.108 48.8 0.48 2.09 0.819 0.087 1.62 0.0021 16200 PRS_PLINK_1.58489319246107e.102 TRUE 370 Keratitis Both 4 18 7 sense organs darkseagreen4 18, 4 5, 2 4, 1 4, 1 5, 0 -0.727 0.873 0.405 0.392 0.483 0.0489 3.25 0.95 4.32 0.826 0.083 2.59 0.000306 4370 -0.983 2.62 0.708 0.15 0.374 0.000823 312 0.033 3.03 0.991 0.004 1.03 0.000489 77.9 PRS_PLINK_1.58489319246107e.102 TRUE 370.1 Corneal ulcer Both 0 6 7 sense organs darkseagreen4 6, 0 2 1 1 2 PRS_PLINK_1.58489319246107e.102 TRUE 370.2 Superficial keratitis Both 2 7 7 sense organs darkseagreen4 7, 2 2, 1 2, 0 1, 0 2, 1 -0.168 49.8 0.997 0.001 0.846 0.368 0.338 0.131 3490 1 0 1.14 0.441 3.36 -0.0599 20900 1 0 0.942 0.103 6.92e+09 0.37 2950 1 0 1.45 0.276 2 PRS_PLINK_1.58489319246107e.102 TRUE 370.3 Keratoconjunctivitis Both 2 8 7 sense organs darkseagreen4 8, 2 1, 1 2, 0 2, 1 2, 0 -0.21 1430 1 0 0.81 0.612 1.15 0.0326 900 1 0 1.03 0.9 1.15 -0.226 1260 1 0 0.798 0.125 1.82 0.00612 26.2 1 0 1.01 0.968 1.07 PRS_PLINK_1.58489319246107e.102 TRUE 370.31 Keratoconjunctivitis sicca Both 0 4 7 sense organs darkseagreen4 4, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 371 Inflammation of the eye Both 11 35 7 sense organs darkseagreen4 35, 11 8, 4 9, 1 8, 5 9, 1 -0.174 0.376 0.644 0.191 0.84 0.414 1.69 0.135 1.2 0.91 0.041 1.14 0.134 10.1 0.839 1.13 0.457 0.34 2.32 0.358 24.4 -0.243 1.39 0.861 0.065 0.784 0.0524 12.8 PRS_PLINK_1.58489319246107e.102 TRUE 371.1 Uveitis, noninfectious or NOS Both 2 9 7 sense organs darkseagreen4 9, 2 3, 2 2, 0 2, 0 2, 0 -0.0756 52.1 0.999 0.001 0.927 0.268 1.72 0.0429 384 1 0 1.04 0.637 1.82 -0.2 4490 1 0 0.819 0.267 1.5 -0.103 447 1 0 0.902 0.381 1.09 PRS_PLINK_1.58489319246107e.102 TRUE 371.2 Conjunctivitis, noninfectious Both 1 16 7 sense organs darkseagreen4 16, 1 4, 0 4, 0 4, 1 4, 0 0.169 0.826 0.838 0.077 1.18 0.276 5.38 2.99 1800000 1 0 19.9 0.907 514 PRS_PLINK_1.58489319246107e.102 TRUE 371.21 Allergic conjunctivitis Both 1 15 7 sense organs darkseagreen4 15, 1 4, 0 4, 0 3, 1 4, 0 0.116 1.11 0.916 0.038 1.12 0.0782 64 -0.0779 1840 1 0 0.925 0.255 2.84 PRS_PLINK_1.58489319246107e.102 TRUE 371.3 Inflammation of eyelids Both 8 25 7 sense organs darkseagreen4 25, 8 7, 3 6, 0 6, 3 6, 2 0.00703 0.654 0.991 0.004 1.01 0.289 3.2 -1.52 2.61 0.56 0.251 0.218 9.82e-07 11.2 0.538 1.83 0.769 0.114 1.71 0.0763 44.8 0.618 1.45 0.67 0.174 1.86 0.0183 22.5 PRS_PLINK_1.58489319246107e.102 TRUE 372 Disorders of conjunctiva Both 4 13 7 sense organs darkseagreen4 13, 4 3, 3 3, 0 3, 1 3, 0 0.247 0.812 0.761 0.119 1.28 0.362 10.1 0.126 239 1 0 1.13 0.678 3.56 -1.78 3810 1 0 0.168 0.05 0.0619 0.995 2690 1 0 2.71 0.12 4.27 PRS_PLINK_1.58489319246107e.102 TRUE 374 Other disorders of eyelids Both 9 22 7 sense organs darkseagreen4 22, 9 5, 3 5, 0 5, 3 6, 3 0.166 0.511 0.745 0.128 1.18 0.478 3.71 -1.44 2.18 0.511 0.292 0.238 0.00324 5.65 -1.29 1.67 0.44 0.356 0.275 0.000309 3.52 -0.508 2.04 0.803 0.095 0.602 0.0206 23.9 PRS_PLINK_1.58489319246107e.102 TRUE 374.1 Ectropion or entropion Both 1 5 7 sense organs darkseagreen4 5, 1 1, 0 1, 0 1, 0 1, 1 0.0235 2100 1 0 1.02 0.64 2.48 -0.00459 35.5 1 0 0.995 0.944 1.03 PRS_PLINK_1.58489319246107e.102 TRUE 374.2 Lagophthalmos Both 1 3 7 sense organs darkseagreen4 3, 1 1, 1 1, 0 1, 1 1, 0 -0.894 4770 1 0 0.409 0.0139 183 PRS_PLINK_1.58489319246107e.102 TRUE 374.3 Ptosis of eyelid Both 2 7 7 sense organs darkseagreen4 7, 2 2, 2 2, 0 1, 0 2, 0 -1.54 30.7 0.96 0.018 0.214 0.203 6.38 -0.325 3850 1 0 0.722 0.078 1.99 -0.542 749 0.999 0 0.582 0.148 2.45 -0.113 322 1 0 0.893 0.535 1.12 PRS_PLINK_1.58489319246107e.102 TRUE 374.6 Dermatochalasis Both 1 9 7 sense organs darkseagreen4 9, 1 3, 1 2, 0 2, 0 2, 0 0.00124 6.68 1 0 1 0.0553 6.96 -7.16 18500 1 0 0.000775 8.38e-13 6190000 2.75 3470 0.999 0 15.7 0.184 14900000 0.0281 2610 1 0 1.03 0.662 2.34 PRS_PLINK_1.58489319246107e.102 TRUE 375 Disorders of lacrimal system Both 12 25 7 sense organs darkseagreen4 25, 12 6, 7 6, 0 6, 5 6, 0 -0.236 0.455 0.605 0.218 0.79 0.348 1.85 -1.16 1.71 0.496 0.304 0.313 0.00293 5.03 0.557 1.18 0.638 0.195 1.75 0.253 69.8 -1.78 1.55 0.251 0.601 0.169 0.00379 1.71 PRS_PLINK_1.58489319246107e.102 TRUE 375.1 Dry eyes Both 14 24 7 sense organs darkseagreen4 24, 14 5, 6 6, 1 6, 4 6, 3 -0.0169 0.428 0.969 0.014 0.983 0.466 2.14 -0.449 1.34 0.738 0.132 0.638 0.0441 8.31 0.29 1.33 0.828 0.082 1.34 0.154 19.4 -1.07 1.32 0.417 0.38 0.343 0.0209 2.63 PRS_PLINK_1.58489319246107e.102 TRUE 375.2 Epiphora Both 1 7 7 sense organs darkseagreen4 7, 1 2, 1 2, 0 1, 0 2, 0 0.499 9120000 1 0 1.65 0.575 33.5 0.0121 864 1 0 1.01 0.63 1.7 0.0011 69.8 1 0 1 0.964 1.02 -0.000985 12500 1 0 0.999 0.0148 60.6 PRS_PLINK_1.58489319246107e.102 TRUE 376 Disorders of the orbit Both 1 4 7 sense organs darkseagreen4 4, 1 1, 1 1, 0 1, 0 1, 0 1.13 5230 1 0 3.11 5.78e-06 21600000 0.0173 66.3 1 0 1.02 0.911 1.16 0.0179 69.1 1 0 1.02 0.939 1.14 -0.0111 68.3 1 0 0.989 0.579 6.92 PRS_PLINK_1.58489319246107e.102 TRUE 377 Disorders of optic nerve and visual pathways Both 3 10 7 sense organs darkseagreen4 10, 3 3, 1 2, 0 2, 0 3, 2 0.905 1.78 0.612 0.213 2.47 0.127 196 -0.000321 810 1 0 1 0.425 1.57 -0.129 9080000 1 0 0.879 0.173 271 0.263 12200000 1 0 1.3 0.496 7.78 PRS_PLINK_1.58489319246107e.102 TRUE 377.1 Optic atrophy Both 2 3 7 sense organs darkseagreen4 3, 2 1, 1 1, 0 1, 1 1, 1 -3.82 13000 1 0 0.022 1.25e-07 320000 -11.2 8.56e+08 1 0 1.35e-05 3.61e-18 10500000 8.92 1.06e+09 1 0 7490 8.12e-10 2.63e+15 PRS_PLINK_1.58489319246107e.102 TRUE 377.3 Optic neuritis/neuropathy Both 2 5 7 sense organs darkseagreen4 5, 2 2, 1 1, 0 1, 0 1, 1 0.0134 4560000 1 0 1.01 0.532 1.61 -0.0653 970 1 0 0.937 0.866 1.68 -0.0417 1250 1 0 0.959 0.601 1.45 -0.144 1660 1 0 0.866 0.565 2.88 PRS_PLINK_1.58489319246107e.102 TRUE 378 Strabismus and other disorders of binocular eye movements Both 6 13 7 sense organs darkseagreen4 13, 6 4, 4 3, 0 3, 1 3, 1 -0.143 0.842 0.865 0.063 0.867 0.191 3.51 0.0639 7.18 0.993 0.003 1.07 0.675 1.56 8.24 20 0.681 0.167 3800 5.17e-09 3.35e+18 -0.533 2.01 0.791 0.102 0.587 0.000173 0.696 PRS_PLINK_1.58489319246107e.102 TRUE 378.1 Strabismus (not specified as paralytic) Both 5 11 7 sense organs darkseagreen4 11, 5 3, 2 3, 1 2, 1 3, 1 0.397 1.16 0.733 0.135 1.49 0.25 12.5 0.338 15.9 0.983 0.007 1.4 0.0015 4.63 0.923 318 0.998 0.001 2.52 0.557 23 0.659 27.3 0.981 0.008 1.93 6.55e-06 2.36 PRS_PLINK_1.58489319246107e.102 TRUE 378.2 Nystagmus and other irregular eye movements Both 1 3 7 sense organs darkseagreen4 3, 1 1, 1 1, 0 1, 0 1, 1 0.791 22300 1 0 2.21 0.0441 940 0.0582 18800 1 0 1.06 0.14 239 0.616 19200 1 0 1.85 0.273 4.79 PRS_PLINK_1.58489319246107e.102 TRUE 378.5 Paralytic strabismus Both 1 3 7 sense organs darkseagreen4 3, 1 1, 1 1, 0 1, 0 1, 1 -0.285 110000 1 0 0.752 0.00636 5.92 -0.00255 129 1 0 0.997 0.995 1 0.00157 80.8 1 0 1 0.976 1.02 PRS_PLINK_1.58489319246107e.102 TRUE 379 Other disorders of eye Both 19 26 7 sense organs darkseagreen4 26, 19 6, 7 6, 2 6, 5 7, 5 0.0857 0.408 0.834 0.079 1.09 0.531 2.37 -0.15 1.21 0.901 0.045 0.861 0.0801 14.5 -0.347 1.17 0.767 0.115 0.707 0.0806 9.78 -0.0998 1.03 0.923 0.035 0.905 0.157 5.16 PRS_PLINK_1.58489319246107e.102 TRUE 379.1 Scleritis and episcleritis Both 0 3 7 sense organs darkseagreen4 3, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 379.2 Disorders of vitreous body Both 16 16 7 sense organs darkseagreen4 16, 16 4, 7 4, 1 4, 3 4, 5 -0.109 0.534 0.839 0.076 0.897 0.333 2.32 -0.405 1.48 0.785 0.105 0.667 0.0602 7.57 -0.886 4.04 0.826 0.083 0.412 7.76e-08 444 0.0823 1.13 0.942 0.026 1.09 0.164 9.19 PRS_PLINK_1.58489319246107e.102 TRUE 379.3 Aphakia and other disorders of lens Both 0 5 7 sense organs darkseagreen4 5, 0 2 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 379.4 Anomalies of pupillary function Both 1 2 7 sense organs darkseagreen4 2, 1 1, 1 1, 0 1, 1 1, 0 0.00337 245 1 0 1 0.805 1.1 0.00311 296 1 0 1 0.686 1.25 PRS_PLINK_1.58489319246107e.102 TRUE 379.5 Disorders of iris and ciliary body Both 0 3 7 sense organs darkseagreen4 3, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 379.9 Pain, swelling or discharge of eye Both 6 18 7 sense organs darkseagreen4 18, 6 5, 3 4, 0 4, 2 5, 1 -0.664 0.659 0.313 0.504 0.515 0.148 1.54 -0.544 1.83 0.767 0.115 0.581 0.551 0.65 -0.199 1.63 0.903 0.044 0.82 0.0549 8.95 -1.36 2.93 0.644 0.191 0.258 1.81e-06 305000 PRS_PLINK_1.58489319246107e.102 TRUE 380 Disorders of external ear Both 6 22 7 sense organs darkseagreen4 22, 6 6, 0 5, 2 5, 2 6, 2 0.216 0.582 0.711 0.148 1.24 0.449 4.64 0.715 2.44 0.769 0.114 2.04 0.0522 912 -0.678 3 0.821 0.086 0.508 0.00358 1420 -1.15 3.69 0.754 0.123 0.315 0.000169 712 PRS_PLINK_1.58489319246107e.102 TRUE 380.1 Otitis externa Both 2 26 7 sense organs darkseagreen4 26, 2 6, 1 6, 0 6, 0 7, 1 0.371 0.678 0.584 0.234 1.45 0.394 10.1 -0.085 1.33 0.949 0.023 0.919 0.487 2.14 -0.939 3.1 0.762 0.118 0.391 0.00311 625 -0.162 2 0.936 0.029 0.851 0.000204 1750 PRS_PLINK_1.58489319246107e.102 TRUE 380.4 Impacted cerumen Both 6 28 7 sense organs darkseagreen4 28, 6 7, 0 7, 2 7, 2 7, 2 0.287 0.565 0.612 0.213 1.33 0.44 4.7 0.451 1.62 0.781 0.107 1.57 0.0652 39.7 -0.379 1.75 0.828 0.082 0.685 0.0274 124 -2.11 2.94 0.474 0.325 0.122 0.000211 4860 PRS_PLINK_1.58489319246107e.102 TRUE 381 Otitis media and Eustachian tube disorders Both 7 50 7 sense organs darkseagreen4 50, 7 13, 1 12, 0 12, 1 13, 5 0.507 0.536 0.344 0.463 1.66 0.558 6.58 -0.419 1.33 0.753 0.123 0.657 0.00101 49 0.937 1.64 0.568 0.246 2.55 0.134 434 1.3 1.51 0.389 0.41 3.67 0.134 3210000 PRS_PLINK_1.58489319246107e.102 TRUE 381.1 Otitis media Both 5 45 7 sense organs darkseagreen4 45, 5 12, 1 11, 0 11, 1 11, 3 0.181 0.519 0.728 0.138 1.2 0.379 4.44 -0.134 1.3 0.918 0.037 0.875 0.00302 45.5 1.1 1.71 0.52 0.284 3 0.155 599 0.559 1.39 0.688 0.163 1.75 0.00107 995 PRS_PLINK_1.58489319246107e.102 TRUE 381.11 Suppurative and unspecified otitis media Both 4 37 7 sense organs darkseagreen4 37, 4 10, 1 9, 0 9, 1 9, 2 -0.0554 0.558 0.921 0.036 0.946 0.248 4.33 -0.504 1.5 0.737 0.133 0.604 0.00247 61.8 0.943 1.7 0.578 0.238 2.57 0.163 789 0.328 1.92 0.864 0.063 1.39 0.00889 755 PRS_PLINK_1.58489319246107e.102 TRUE 381.2 Eustachian tube disorders Both 4 31 7 sense organs darkseagreen4 31, 4 8, 0 8, 0 7, 0 8, 4 1.2 0.992 0.225 0.647 3.33 0.264 1750 1.37 1.96 0.485 0.314 3.93 0.00665 439000 PRS_PLINK_1.58489319246107e.102 TRUE 381.3 Mastoiditis & related conditions Both 0 5 7 sense organs darkseagreen4 5, 0 2 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 381.9 Otorrhea Both 0 5 7 sense organs darkseagreen4 5, 0 2 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 382 Otalgia Both 4 29 7 sense organs darkseagreen4 29, 4 8, 1 7, 0 7, 1 7, 1 -0.149 0.671 0.824 0.084 0.861 0.0488 3.55 -0.247 2.31 0.915 0.039 0.781 0.00554 394 0.476 2.3 0.836 0.078 1.61 0.00372 438 1.15 2.23 0.607 0.217 3.15 0.00248 3100 PRS_PLINK_1.58489319246107e.102 TRUE 383 Otosclerosis Both 0 4 7 sense organs darkseagreen4 4, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 384 Other disorders of tympanic membrane Both 1 5 7 sense organs darkseagreen4 5, 1 2, 0 1, 0 1, 0 1, 1 -0.0642 409 1 0 0.938 0.114 2.92 -0.061 8690 1 0 0.941 0.00825 4.61e+15 PRS_PLINK_1.58489319246107e.102 TRUE 384.1 Myringitis Both 0 2 7 sense organs darkseagreen4 2, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 384.4 Perforation of tympanic membrane Both 1 1 7 sense organs darkseagreen4 1, 1 -0.00484 81 1 0 0.995 0.873 2.78 PRS_PLINK_1.58489319246107e.102 TRUE 385 Other disorders of middle ear and mastoid Both 0 6 7 sense organs darkseagreen4 6, 0 2 1 1 2 PRS_PLINK_1.58489319246107e.102 TRUE 385.3 Cholesteatoma Both 0 4 7 sense organs darkseagreen4 4, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 385.5 Tympanosclerosis and middle ear disease related to otitis media Both 0 3 7 sense organs darkseagreen4 3, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 386 Vertiginous syndromes and other disorders of vestibular system Both 4 23 7 sense organs darkseagreen4 23, 4 6, 1 6, 0 5, 1 6, 2 -0.221 0.645 0.732 0.136 0.802 0.229 2.89 -0.903 2.17 0.677 0.169 0.405 0.00593 12.5 -2.45 4.89 0.616 0.21 0.0861 5e-07 103 -1.9 2.17 0.383 0.417 0.15 0.000171 3.62 PRS_PLINK_1.58489319246107e.102 TRUE 386.1 Meniere's disease Both 0 2 7 sense organs darkseagreen4 2, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 386.2 Peripheral or central vertigo Both 4 17 7 sense organs darkseagreen4 17, 4 5, 1 4, 0 4, 1 4, 2 0.023 0.706 0.974 0.011 1.02 0.196 5.6 0.8 145 0.996 0.002 2.22 0.938 0.965 -0.351 2.88 0.903 0.044 0.704 0.605 1.31 -1.33 3.03 0.662 0.179 0.266 0.223 23.6 PRS_PLINK_1.58489319246107e.102 TRUE 386.21 Central origin vertigo Both 3 14 7 sense organs darkseagreen4 14, 3 4, 1 3, 0 3, 1 4, 1 -0.615 0.905 0.497 0.304 0.541 0.0317 4.28 -0.362 4640 1 0 0.696 0.0235 1.85 0.0553 250 1 0 1.06 0.709 2.3 -0.973 57.6 0.987 0.006 0.378 0.0839 0.713 PRS_PLINK_1.58489319246107e.102 TRUE 386.3 Labyrinthitis Both 3 19 7 sense organs darkseagreen4 19, 3 5, 1 5, 0 4, 1 5, 1 -0.594 0.82 0.469 0.329 0.552 0.035 3.4 1.09 4.76 0.818 0.087 2.99 2.65 3.33 -2.12 8.76 0.808 0.092 0.119 2.72e-07 59800 -1.48 2.21 0.503 0.298 0.227 0.00542 5.46 PRS_PLINK_1.58489319246107e.102 TRUE 386.9 Dizziness and giddiness (Light-headedness and vertigo) Both 12 46 7 sense organs darkseagreen4 46, 12 11, 2 11, 1 11, 3 12, 6 0.463 0.412 0.261 0.583 1.59 0.748 3.84 -1.79 1.65 0.277 0.557 0.167 4.01e-05 3.89 1.05 1.98 0.595 0.226 2.86 0.0252 18900 0.797 1.06 0.451 0.346 2.22 0.351 158 PRS_PLINK_1.58489319246107e.102 TRUE 388 Other disorders of ear Both 0 7 7 sense organs darkseagreen4 7, 0 2 2 1 2 PRS_PLINK_1.58489319246107e.102 TRUE 389 Hearing loss Both 13 49 7 sense organs darkseagreen4 49, 13 12, 2 12, 2 12, 5 12, 4 0.564 0.446 0.206 0.686 1.76 0.75 4.97 -0.162 1.29 0.9 0.046 0.85 0.00048 47.5 1.17 1.22 0.339 0.47 3.21 0.231 68 0.345 1.11 0.756 0.121 1.41 0.167 24.1 PRS_PLINK_1.58489319246107e.102 TRUE 389.1 Sensorineural hearing loss Both 7 26 7 sense organs darkseagreen4 26, 7 7, 2 6, 0 6, 1 7, 4 -0.00817 0.761 0.991 0.004 0.992 0.103 4.71 -0.643 1.58 0.684 0.165 0.526 0.006 15.7 -0.696 1.96 0.723 0.141 0.499 0.000539 33.3 0.548 1.55 0.724 0.14 1.73 0.0222 195 PRS_PLINK_1.58489319246107e.102 TRUE 389.2 Conductive hearing loss Both 1 11 7 sense organs darkseagreen4 11, 1 2, 0 3, 0 2, 0 3, 1 -0.369 2.07 0.859 0.066 0.691 0.673 0.71 -0.922 10700 1 0 0.398 0.114 6.28 PRS_PLINK_1.58489319246107e.102 TRUE 389.3 Degenerative and vascular disorders of ear Both 0 2 7 sense organs darkseagreen4 2, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 389.4 Tinnitus Both 5 27 7 sense organs darkseagreen4 27, 5 7, 0 7, 0 6, 3 7, 2 0.902 0.711 0.204 0.69 2.46 0.747 16.7 1.66 1.65 0.313 0.505 5.28 0.347 1110 1.01 1.72 0.557 0.254 2.74 0.0159 139 PRS_PLINK_1.58489319246107e.102 TRUE 389.5 Disorders of acoustic nerve Both 0 1 7 sense organs darkseagreen4 1, 0 PRS_PLINK_1.58489319246107e.102 TRUE 394 Rheumatic disease of the heart valves Both 1 8 8 circulatory system red 8, 1 2, 1 2, 0 2, 0 2, 0 0.221 34.4 0.995 0.002 1.25 0.00092 596 -0.0446 2450 1 0 0.956 0.0214 3.05 0.143 4530 1 0 1.15 0.645 1.8 -0.014 1840 1 0 0.986 0.602 1.6 PRS_PLINK_1.58489319246107e.102 TRUE 394.1 Mitral valve stenosis and aortic valve stenosis Both 1 1 8 circulatory system red 1, 1 0.00869 58.7 1 0 1.01 0.706 1.17 PRS_PLINK_1.58489319246107e.102 TRUE 394.2 Mitral valve disease Both 0 3 8 circulatory system red 3, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 394.7 Disease of tricuspid valve Both 0 2 8 circulatory system red 2, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 395 Heart valve disorders Both 4 31 8 circulatory system red 31, 4 7, 0 8, 2 7, 0 8, 2 0.528 0.506 0.297 0.527 1.7 0.694 5.87 -0.273 2.07 0.895 0.048 0.761 0.000108 101 0.413 1.81 0.82 0.086 1.51 0.00384 307 PRS_PLINK_1.58489319246107e.102 TRUE 395.1 Nonrheumatic mitral valve disorders Both 2 18 8 circulatory system red 18, 2 5, 1 4, 0 4, 0 5, 1 0.617 1.02 0.547 0.262 1.85 0.244 59 -0.374 29.1 0.99 0.004 0.688 0.272 0.63 0.667 257 0.998 0.001 1.95 1.58 1110000 0.434 2.01 0.829 0.081 1.54 0.0846 39 PRS_PLINK_1.58489319246107e.102 TRUE 395.2 Nonrheumatic aortic valve disorders Both 2 14 8 circulatory system red 14, 2 4, 1 3, 0 3, 0 4, 1 0.0844 0.842 0.92 0.036 1.09 0.0783 5.87 -0.888 879 0.999 0 0.412 0.147 0.541 -0.0719 1100 1 0 0.931 0.432 1.83 0.0409 10.3 0.997 0.001 1.04 9.27e-09 10200000 PRS_PLINK_1.58489319246107e.102 TRUE 395.3 Nonrheumatic tricuspid valve disorders Both 0 4 8 circulatory system red 4, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 395.4 Nonrheumatic pulmonary valve disorders Both 0 2 8 circulatory system red 2, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 395.6 Heart valve replaced Both 0 9 8 circulatory system red 9, 0 3 2 2 2 PRS_PLINK_1.58489319246107e.102 TRUE 396 Abnormal heart sounds Both 4 45 8 circulatory system red 45, 4 11, 1 11, 0 11, 1 11, 2 0.675 0.569 0.236 0.628 1.96 0.709 14.8 -0.624 1.24 0.614 0.212 0.536 0.000699 5.13 0.379 1.61 0.814 0.09 1.46 0.0413 4100 -0.786 1.59 0.621 0.207 0.455 2.35e-07 20.2 PRS_PLINK_1.58489319246107e.102 TRUE 401 Hypertension Both 29 35 8 circulatory system red 35, 29 9, 8 9, 5 8, 6 9, 9 -0.151 0.316 0.633 0.198 0.86 0.465 1.53 0.0406 0.975 0.967 0.015 1.04 0.155 6.52 -0.0109 1.07 0.992 0.004 0.989 0.136 7.87 0.0464 0.998 0.963 0.016 1.05 0.164 7.75 PRS_PLINK_1.58489319246107e.102 TRUE 401.1 Essential hypertension Both 29 35 8 circulatory system red 35, 29 9, 8 9, 5 8, 6 9, 9 -0.151 0.316 0.633 0.198 0.86 0.465 1.53 0.0406 0.975 0.967 0.015 1.04 0.155 6.52 -0.0109 1.07 0.992 0.004 0.989 0.136 7.87 0.0464 0.998 0.963 0.016 1.05 0.164 7.75 PRS_PLINK_1.58489319246107e.102 TRUE 401.2 Hypertensive heart and/or renal disease Both 1 19 8 circulatory system red 19, 1 5, 1 5, 0 4, 0 5, 0 -0.402 1.27 0.751 0.124 0.669 0.0113 43.9 -0.132 4.06 0.974 0.011 0.876 0.000203 393 1.47e-14 3.74 1 0 1 0.00298 236 -1.25 2.99 0.675 0.171 0.285 0.00178 40.7 PRS_PLINK_1.58489319246107e.102 TRUE 401.21 Hypertensive heart disease Both 0 7 8 circulatory system red 7, 0 2 2 1 2 PRS_PLINK_1.58489319246107e.102 TRUE 401.22 Hypertensive chronic kidney disease Both 1 18 8 circulatory system red 18, 1 5, 1 4, 0 4, 0 5, 0 -0.224 1.26 0.859 0.066 0.799 0.0255 44 0.0433 6.67 0.995 0.002 1.04 1.36e-05 11500 1.47e-14 3.74 1 0 1 0.00298 236 -1.25 2.99 0.675 0.171 0.285 0.00178 40.7 PRS_PLINK_1.58489319246107e.102 TRUE 401.3 Other hypertensive complications Both 5 23 8 circulatory system red 23, 5 6, 1 6, 0 5, 0 6, 4 0.654 0.713 0.359 0.445 1.92 0.481 15.1 -0.0622 3.18 0.984 0.007 0.94 0.00029 156 -0.0765 11.4 0.995 0.002 0.926 3.7e-10 5.3e+07 1.51 2.33 0.516 0.287 4.53 0.112 7480000 PRS_PLINK_1.58489319246107e.102 TRUE 411 Ischemic Heart Disease Both 13 34 8 circulatory system red 34, 13 8, 3 8, 2 8, 1 9, 7 0.352 0.415 0.396 0.402 1.42 0.694 3.5 -0.829 1.4 0.554 0.256 0.437 0.00916 12 -0.0434 2.03 0.983 0.007 0.958 0.00715 220 1.17 1.26 0.353 0.452 3.21 0.392 209 PRS_PLINK_1.58489319246107e.102 TRUE 411.1 Unstable angina (intermediate coronary syndrome) Both 0 12 8 circulatory system red 12, 0 3 3 3 3 PRS_PLINK_1.58489319246107e.102 TRUE 411.2 Myocardial infarction Both 5 25 8 circulatory system red 25, 5 7, 1 6, 2 6, 1 6, 1 0.474 0.723 0.512 0.291 1.61 0.44 12.9 -0.28 1.57 0.859 0.066 0.756 0.00939 110 -0.275 2.55 0.914 0.039 0.759 0.00218 1410 1.11 2.06 0.592 0.228 3.02 0.0724 786 PRS_PLINK_1.58489319246107e.102 TRUE 411.3 Angina pectoris Both 3 22 8 circulatory system red 22, 3 6, 1 5, 0 5, 0 6, 2 0.579 0.817 0.479 0.32 1.78 0.412 18.5 -0.494 1.7 0.771 0.113 0.61 0.0129 13.5 0.413 2.6 0.874 0.059 1.51 0.000237 168 1.51 2 0.451 0.346 4.53 0.267 33800 PRS_PLINK_1.58489319246107e.102 TRUE 411.4 Coronary atherosclerosis Both 7 31 8 circulatory system red 31, 7 8, 2 8, 1 7, 2 8, 2 -0.338 0.582 0.562 0.25 0.713 0.2 2.38 -0.493 1.43 0.731 0.136 0.611 0.0241 49.2 0.131 2.37 0.956 0.02 1.14 0.00017 1.52e+14 -0.499 1.94 0.797 0.099 0.607 4.85e-06 1010 PRS_PLINK_1.58489319246107e.102 TRUE 411.41 Aneurysm and dissection of heart Both 0 3 8 circulatory system red 3, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 411.8 Other chronic ischemic heart disease, unspecified Both 7 30 8 circulatory system red 30, 7 8, 2 7, 0 7, 2 8, 3 0.949 0.702 0.177 0.753 2.58 0.766 16.4 -0.415 1.95 0.831 0.08 0.66 0.0013 28.8 -0.0735 2.69 0.978 0.01 0.929 0.00345 1300000 1.46 1.76 0.407 0.391 4.3 0.256 480 PRS_PLINK_1.58489319246107e.102 TRUE 411.9 Other acute and subacute forms of ischemic heart disease Both 0 4 8 circulatory system red 4, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 414 Other forms of chronic heart disease Both 4 26 8 circulatory system red 26, 4 7, 1 6, 1 6, 2 7, 0 -0.0865 0.688 0.9 0.046 0.917 0.214 7.29 -0.45 1.63 0.782 0.107 0.638 0.00318 17.6 0.776 1.88 0.68 0.168 2.17 0.0739 2080 0.525 2.55 0.837 0.077 1.69 2.4e-05 149 PRS_PLINK_1.58489319246107e.102 TRUE 414.2 ASCVD Both 1 10 8 circulatory system red 10, 1 3, 0 2, 1 2, 0 3, 0 0.12 2.12 0.955 0.02 1.13 0.00958 25.1 -3.33 1030 0.997 0.001 0.0357 1.92e-06 12400 PRS_PLINK_1.58489319246107e.102 TRUE 415 Pulmonary heart disease Both 4 33 8 circulatory system red 33, 4 8, 1 8, 0 8, 1 8, 2 0.167 0.589 0.776 0.11 1.18 0.259 4.89 -0.0469 1.91 0.98 0.009 0.954 0.0154 2300 -0.363 1.86 0.845 0.073 0.695 0.00452 141 0.545 1.44 0.705 0.152 1.72 0.172 41.1 PRS_PLINK_1.58489319246107e.102 TRUE 415.1 Acute pulmonary heart disease Both 1 19 8 circulatory system red 19, 1 4, 0 5, 0 4, 0 5, 1 0.318 0.88 0.718 0.144 1.37 0.234 18.1 -5.33e-10 23.6 1 0 1 0.274 3.67 PRS_PLINK_1.58489319246107e.102 TRUE 415.11 Pulmonary embolism and infarction, acute Both 1 19 8 circulatory system red 19, 1 4, 0 5, 0 4, 0 5, 1 0.318 0.88 0.718 0.144 1.37 0.234 18.1 -5.33e-10 23.6 1 0 1 0.274 3.67 PRS_PLINK_1.58489319246107e.102 TRUE 415.2 Chronic pulmonary heart disease Both 4 20 8 circulatory system red 20, 4 4, 0 5, 1 5, 1 5, 2 0.506 0.593 0.393 0.405 1.66 0.588 20.3 4.73e-15 5.68 1 0 1 0.000151 5790 1.01e-13 3.09 1 0 1 0.00358 100 -0.00268 67.2 1 0 0.997 0.596 1.64 PRS_PLINK_1.58489319246107e.102 TRUE 415.21 Primary pulmonary hypertension Both 3 9 8 circulatory system red 9, 3 3, 0 2, 1 2, 1 2, 1 -0.0657 1.22 0.957 0.019 0.936 0.0624 6.27 -0.59 401 0.999 0.001 0.554 0.000658 748 0.0132 1290 1 0 1.01 0.75 1.84 -0.298 24000 1 0 0.743 0.142 5.8 PRS_PLINK_1.58489319246107e.102 TRUE 416 Cardiomegaly Both 1 15 8 circulatory system red 15, 1 4, 1 4, 0 3, 0 4, 0 -0.193 1.14 0.866 0.063 0.825 0.0177 16.4 -0.602 69.9 0.993 0.003 0.548 0.0355 2.71 -0.00911 48.2 1 0 0.991 0.0688 14.3 1.26 127 0.992 0.003 3.52 2.39e-05 252000 PRS_PLINK_1.58489319246107e.102 TRUE 418 Nonspecific chest pain Both 28 35 8 circulatory system red 35, 28 8, 6 9, 4 8, 9 9, 9 0.332 0.337 0.324 0.489 1.39 0.751 2.71 -0.647 0.981 0.509 0.293 0.523 0.0777 3.06 0.271 1.27 0.831 0.08 1.31 0.108 19 -0.171 1.02 0.867 0.062 0.843 0.0944 5.81 PRS_PLINK_1.58489319246107e.102 TRUE 418.1 Precordial pain Both 4 12 8 circulatory system red 12, 4 3, 1 3, 0 3, 1 3, 2 0.0784 1.49 0.958 0.019 1.08 0.0533 3950 0.34 746 1 0 1.41 0.675 1.57 -0.77 965 0.999 0 0.463 0.0742 89.9 0.326 2940000 1 0 1.39 0.506 4.59 PRS_PLINK_1.58489319246107e.102 TRUE 420 Carditis Both 1 16 8 circulatory system red 16, 1 4, 0 4, 1 4, 0 4, 0 -0.454 0.99 0.647 0.189 0.635 0.0537 11 -0.11 36.8 0.998 0.001 0.896 0.000133 4100 PRS_PLINK_1.58489319246107e.102 TRUE 420.2 Pericarditis Both 1 7 8 circulatory system red 7, 1 2, 0 2, 1 1, 0 2, 0 -0.368 211 0.999 0.001 0.692 0.626 1.19 0.00135 1160 1 0 1 0.835 1.18 PRS_PLINK_1.58489319246107e.102 TRUE 420.21 Acute pericarditis Both 1 3 8 circulatory system red 3, 1 1, 0 1, 1 1, 0 1, 0 -0.389 10800 1 0 0.678 0.016 6.95 -0.0117 17.2 0.999 0 0.988 0.874 1.28 PRS_PLINK_1.58489319246107e.102 TRUE 420.22 Chronic pericarditis Both 1 0 8 circulatory system red 0, 1 PRS_PLINK_1.58489319246107e.102 TRUE 420.3 Endocarditis Both 0 9 8 circulatory system red 9, 0 3 2 2 2 PRS_PLINK_1.58489319246107e.102 TRUE 425 Cardiomyopathy Both 3 19 8 circulatory system red 19, 3 5, 0 5, 0 4, 2 5, 1 0.526 0.791 0.506 0.296 1.69 0.294 20.6 0.0812 3.64 0.982 0.008 1.08 0.00359 191 0.591 3.63 0.871 0.06 1.81 0.0189 476 PRS_PLINK_1.58489319246107e.102 TRUE 425.1 Primary/intrinsic cardiomyopathies Both 3 19 8 circulatory system red 19, 3 5, 0 5, 0 4, 2 5, 1 0.526 0.791 0.506 0.296 1.69 0.294 20.6 0.0812 3.64 0.982 0.008 1.08 0.00359 191 0.591 3.63 0.871 0.06 1.81 0.0189 476 PRS_PLINK_1.58489319246107e.102 TRUE 425.11 Hypertrophic obstructive cardiomyopathy Both 0 1 8 circulatory system red 1, 0 PRS_PLINK_1.58489319246107e.102 TRUE 425.12 Other hypertrophic cardiomyopathy Both 0 1 8 circulatory system red 1, 0 PRS_PLINK_1.58489319246107e.102 TRUE 425.2 Secondary/extrinsic cardiomyopathies Both 0 2 8 circulatory system red 2, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 425.8 Other cardiomyopathy Both 0 1 8 circulatory system red 1, 0 PRS_PLINK_1.58489319246107e.102 TRUE 426 Cardiac conduction disorders Both 17 33 8 circulatory system red 33, 17 9, 3 8, 5 8, 4 8, 5 0.305 0.393 0.438 0.359 1.36 0.665 2.97 0.568 0.967 0.557 0.254 1.76 0.343 11.1 0.428 1.16 0.712 0.148 1.53 0.198 13.8 0.544 1.09 0.617 0.209 1.72 0.255 25.3 PRS_PLINK_1.58489319246107e.102 TRUE 426.2 Atrioventricular [AV] block Both 0 12 8 circulatory system red 12, 0 3 3 3 3 PRS_PLINK_1.58489319246107e.102 TRUE 426.21 First degree AV block Both 0 10 8 circulatory system red 10, 0 3 2 2 3 PRS_PLINK_1.58489319246107e.102 TRUE 426.23 Second degree AV block Both 0 2 8 circulatory system red 2, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 426.24 Atrioventricular block, complete Both 0 3 8 circulatory system red 3, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 426.25 Other heart block Both 0 2 8 circulatory system red 2, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 426.3 Bundle branch block Both 2 16 8 circulatory system red 16, 2 4, 1 4, 0 4, 0 4, 1 -0.293 0.875 0.738 0.132 0.746 0.0121 34.3 3.65e-11 133 1 0 1 3.67e-08 29700000 -1.25 60.9 0.984 0.007 0.286 0.00167 48.4 -1.48 49.2 0.976 0.011 0.227 0.207 0.249 PRS_PLINK_1.58489319246107e.102 TRUE 426.31 Right bundle branch block Both 2 7 8 circulatory system red 7, 2 2, 0 2, 1 1, 0 2, 1 0.0319 921 1 0 1.03 0.748 1.48 0.0378 2510 1 0 1.04 0.563 1.08 -1.39e-06 5100 1 0 1 0.454 1.92 PRS_PLINK_1.58489319246107e.102 TRUE 426.32 Left bundle branch block Both 0 11 8 circulatory system red 11, 0 3 3 2 3 PRS_PLINK_1.58489319246107e.102 TRUE 426.4 Anomalous atrioventricular excitation Both 0 1 8 circulatory system red 1, 0 PRS_PLINK_1.58489319246107e.102 TRUE 426.7 Abnormal electrocardiogram [ECG] [EKG] Both 16 31 8 circulatory system red 31, 16 8, 3 8, 5 7, 4 8, 4 0.229 0.411 0.577 0.238 1.26 0.594 2.8 0.543 0.983 0.581 0.236 1.72 0.33 12.2 0.514 1.19 0.667 0.176 1.67 0.222 17.2 0.556 1.13 0.623 0.206 1.74 0.257 25.9 PRS_PLINK_1.58489319246107e.102 TRUE 426.8 Other cardiac conduction disorders Both 0 5 8 circulatory system red 5, 0 2 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 426.9 Cardiac pacemaker/device in situ Both 1 11 8 circulatory system red 11, 1 3, 0 3, 1 2, 0 3, 0 -0.343 0.909 0.706 0.151 0.709 0.138 3.06 0.00313 59.9 1 0 1 0.732 1.51 PRS_PLINK_1.58489319246107e.102 TRUE 426.91 Cardiac pacemaker in situ Both 0 4 8 circulatory system red 4, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 426.92 Cardiac defibrillator in situ Both 0 6 8 circulatory system red 6, 0 2 1 1 2 PRS_PLINK_1.58489319246107e.102 TRUE 427 Cardiac dysrhythmias Both 25 33 8 circulatory system red 33, 25 9, 6 8, 4 8, 5 8, 9 0.302 0.339 0.373 0.428 1.35 0.73 2.68 -0.427 1.07 0.69 0.161 0.653 0.0702 4.11 0.383 1.3 0.769 0.114 1.47 0.0402 83.1 0.883 1 0.378 0.423 2.42 0.439 20.2 PRS_PLINK_1.58489319246107e.102 TRUE 427.1 Paroxysmal tachycardia, unspecified Both 4 22 8 circulatory system red 22, 4 6, 0 5, 1 5, 1 6, 2 0.273 0.629 0.665 0.178 1.31 0.397 8.57 -1.74 4.58 0.704 0.152 0.176 1.17e-05 625 0.22 4.05 0.957 0.019 1.25 0.00193 980 0.759 1.88 0.686 0.164 2.14 0.0228 345 PRS_PLINK_1.58489319246107e.102 TRUE 427.11 Paroxysmal supraventricular tachycardia Both 2 14 8 circulatory system red 14, 2 4, 0 3, 1 3, 0 4, 1 -0.1 1.08 0.926 0.033 0.905 0.034 8.57 -0.265 3950 1 0 0.767 0.736 2.1 1.41 29.5 0.962 0.017 4.08 0.213 78.9 PRS_PLINK_1.58489319246107e.102 TRUE 427.12 Paroxysmal ventricular tachycardia Both 2 10 8 circulatory system red 10, 2 3, 0 2, 0 2, 1 3, 1 0.463 1.19 0.698 0.156 1.59 0.282 25.1 -0.267 4360 1 0 0.765 0.269 1.85 2.55 49.2 0.959 0.018 12.7 0.123 13.7 PRS_PLINK_1.58489319246107e.102 TRUE 427.2 Atrial fibrillation and flutter Both 4 22 8 circulatory system red 22, 4 6, 2 5, 0 5, 0 6, 2 -0.327 0.75 0.662 0.179 0.721 0.112 3.37 -0.989 1.68 0.556 0.255 0.372 0.00673 9.56 0.571 2.74 0.835 0.078 1.77 0.0145 214 0.145 1.68 0.931 0.031 1.16 0.005 26 PRS_PLINK_1.58489319246107e.102 TRUE 427.21 Atrial fibrillation Both 4 20 8 circulatory system red 20, 4 5, 2 5, 0 5, 0 5, 2 -0.31 0.805 0.7 0.155 0.734 0.117 3.47 -0.998 1.73 0.564 0.249 0.369 0.00771 6.35 -0.124 2.54 0.961 0.017 0.883 0.0109 53.2 -0.394 2.6 0.88 0.056 0.675 0.00143 53.7 PRS_PLINK_1.58489319246107e.102 TRUE 427.22 Atrial flutter Both 1 11 8 circulatory system red 11, 1 3, 0 3, 0 2, 0 3, 1 0.0997 2.33 0.966 0.015 1.1 0.018 38.7 0.0687 1880 1 0 1.07 0.31 4.06 PRS_PLINK_1.58489319246107e.102 TRUE 427.3 Other specified cardiac dysrhythmias Both 12 33 8 circulatory system red 33, 12 9, 3 8, 3 8, 2 8, 3 0.212 0.452 0.639 0.195 1.24 0.519 3.6 -0.54 1.28 0.673 0.172 0.582 0.00375 5.39 0.686 1.62 0.672 0.172 1.99 0.0232 103 0.946 1.3 0.468 0.33 2.58 0.302 902 PRS_PLINK_1.58489319246107e.102 TRUE 427.4 Cardiac arrest and ventricular fibrillation Both 0 1 8 circulatory system red 1, 0 PRS_PLINK_1.58489319246107e.102 TRUE 427.41 Ventricular fibrillation and flutter Both 0 1 8 circulatory system red 1, 0 PRS_PLINK_1.58489319246107e.102 TRUE 427.42 Cardiac arrest Both 0 1 8 circulatory system red 1, 0 PRS_PLINK_1.58489319246107e.102 TRUE 427.5 Arrhythmia (cardiac) NOS Both 5 32 8 circulatory system red 32, 5 8, 0 8, 2 8, 0 8, 3 0.272 0.556 0.625 0.204 1.31 0.0922 5.43 0.0471 2 0.981 0.008 1.05 0.0101 306 0.762 1.28 0.553 0.257 2.14 0.243 48.9 PRS_PLINK_1.58489319246107e.102 TRUE 427.6 Premature beats Both 4 19 8 circulatory system red 19, 4 5, 1 5, 0 4, 2 5, 1 -0.225 0.893 0.801 0.096 0.798 0.0464 42 -0.734 2.41 0.76 0.119 0.48 0.0126 26.5 3.3 14.5 0.82 0.086 27.1 5.82e-05 7e+06 -0.0811 2.29 0.972 0.012 0.922 0.00334 36.4 PRS_PLINK_1.58489319246107e.102 TRUE 427.61 Supraventricular premature beats Both 1 8 8 circulatory system red 8, 1 2, 0 2, 0 2, 1 2, 0 -0.236 593 1 0 0.79 0.74 1.42 -0.00274 13.7 1 0 0.997 0.84 1.16 PRS_PLINK_1.58489319246107e.102 TRUE 427.7 Tachycardia NOS Both 5 33 8 circulatory system red 33, 5 9, 1 8, 2 8, 1 8, 1 0.359 0.563 0.524 0.281 1.43 0.469 5.69 0.503 1.29 0.696 0.158 1.65 0.147 23.1 0.477 1.45 0.742 0.13 1.61 0.0552 69.4 0.495 1.49 0.74 0.131 1.64 0.0902 23.5 PRS_PLINK_1.58489319246107e.102 TRUE 427.8 Sinoatrial node dysfunction (Bradycardia) Both 0 6 8 circulatory system red 6, 0 2 1 1 2 PRS_PLINK_1.58489319246107e.102 TRUE 427.9 Palpitations Both 9 31 8 circulatory system red 31, 9 8, 3 8, 0 7, 3 8, 3 0.0488 0.491 0.921 0.036 1.05 0.318 2.92 -1.14 1.45 0.431 0.366 0.32 0.00255 3.49 0.0899 1.28 0.944 0.025 1.09 0.102 16.8 0.0966 1.7 0.955 0.02 1.1 0.00511 4510 PRS_PLINK_1.58489319246107e.102 TRUE 428 Congestive heart failure; nonhypertensive Both 3 20 8 circulatory system red 20, 3 5, 0 5, 1 5, 1 5, 1 0.367 0.934 0.694 0.158 1.44 0.0724 461 -1.65e-11 23.7 1 0 1 1.02e-15 1.85e+14 1.52 3.3 0.645 0.19 4.56 0.0143 823 0.0181 4.5 0.997 0.001 1.02 0.000257 14700 PRS_PLINK_1.58489319246107e.102 TRUE 428.1 Congestive heart failure (CHF) NOS Both 2 18 8 circulatory system red 18, 2 5, 0 4, 0 4, 1 5, 1 0.386 0.917 0.674 0.171 1.47 0.0847 278 0.229 2.55 0.929 0.032 1.26 0.0275 55.4 0.942 2.15 0.661 0.18 2.56 0.122 163 PRS_PLINK_1.58489319246107e.102 TRUE 428.2 Heart failure NOS Both 3 18 8 circulatory system red 18, 3 5, 0 4, 0 4, 2 5, 1 0.361 0.912 0.692 0.16 1.43 0.106 341 0.238 2.39 0.92 0.036 1.27 0.0272 40.3 0.8 2.15 0.71 0.149 2.23 0.0957 438 PRS_PLINK_1.58489319246107e.102 TRUE 428.3 Heart failure with reduced EF [Systolic or combined heart failure] Both 2 9 8 circulatory system red 9, 2 3, 0 2, 0 2, 1 2, 1 0.213 1.35 0.875 0.058 1.24 0.145 22.7 -0.0843 6930 1 0 0.919 0.0541 14.5 -0.0995 41500000 1 0 0.905 0.496 2.08 PRS_PLINK_1.58489319246107e.102 TRUE 428.4 Heart failure with preserved EF [Diastolic heart failure] Both 1 11 8 circulatory system red 11, 1 3, 0 3, 0 2, 1 3, 0 0.15 1.1 0.892 0.05 1.16 0.19 14.2 -0.0758 580 1 0 0.927 0.312 4.42 PRS_PLINK_1.58489319246107e.102 TRUE 429 Ill-defined descriptions and complications of heart disease Both 28 35 8 circulatory system red 35, 28 9, 7 9, 6 8, 7 9, 7 -0.00468 0.307 0.988 0.005 0.995 0.558 1.77 -0.303 0.824 0.713 0.147 0.738 0.165 3.06 0.115 1.18 0.923 0.035 1.12 0.0396 13 0.434 0.998 0.663 0.178 1.54 0.267 9.93 PRS_PLINK_1.58489319246107e.102 TRUE 429.1 Heart transplant/surgery Both 2 5 8 circulatory system red 5, 2 2, 0 1, 0 1, 1 1, 1 -0.0042 221 1 0 0.996 0.682 1.34 -0.00308 38.9 1 0 0.997 0.915 1.07 -1.87 1330 0.999 0 0.154 2.27e-05 1150 PRS_PLINK_1.58489319246107e.102 TRUE 429.2 Abnormal function study of cardiovascular system Both 15 30 8 circulatory system red 30, 15 8, 3 7, 4 7, 4 8, 3 -0.144 0.369 0.696 0.157 0.866 0.439 1.7 1.32 1.72 0.442 0.354 3.74 0.149 178 -0.49 1.54 0.75 0.125 0.613 0.00173 34.9 0.102 1.09 0.926 0.034 1.11 0.171 7.49 PRS_PLINK_1.58489319246107e.102 TRUE 429.3 Symptoms involving cardiovascular system Both 18 35 8 circulatory system red 35, 18 9, 5 9, 4 8, 5 9, 4 -0.0453 0.413 0.913 0.04 0.956 0.435 2.14 -0.516 1 0.607 0.217 0.597 0.0806 3.5 -0.0678 1.22 0.956 0.02 0.934 0.0298 30.6 0.312 1.22 0.798 0.098 1.37 0.142 38.1 PRS_PLINK_1.58489319246107e.102 TRUE 429.9 Cardiac complications, not elsewhere classified Both 1 2 8 circulatory system red 2, 1 1, 0 1, 1 1, 0 1, 1 -0.0195 24.9 0.999 0 0.981 0.932 1.01 -0.0077 21.3 1 0 0.992 0.975 1.03 PRS_PLINK_1.58489319246107e.102 TRUE 430 Intracranial hemorrhage Both 1 11 8 circulatory system red 11, 1 3, 0 3, 0 2, 1 3, 0 0.195 2.43 0.936 0.029 1.22 0.0204 219 -0.141 1330 1 0 0.868 0.227 1.55 PRS_PLINK_1.58489319246107e.102 TRUE 430.1 Subarachnoid hemorrhage Both 0 4 8 circulatory system red 4, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 430.2 Intracerebral hemorrhage Both 0 3 8 circulatory system red 3, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 430.3 Subdural hemorrhage Both 0 3 8 circulatory system red 3, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 433 Cerebrovascular disease Both 8 35 8 circulatory system red 35, 8 9, 1 9, 3 8, 2 9, 1 -0.301 0.428 0.482 0.317 0.74 0.277 1.66 -0.583 1.49 0.696 0.157 0.558 0.000335 12.2 -0.356 1.58 0.822 0.085 0.701 1.07e-05 11.5 -0.557 1.64 0.733 0.135 0.573 0.00381 22.3 PRS_PLINK_1.58489319246107e.102 TRUE 433.1 Occlusion and stenosis of precerebral arteries Both 3 15 8 circulatory system red 15, 3 4, 0 4, 2 3, 0 4, 1 -1.61 1.57 0.306 0.515 0.2 0.000323 2.97 -2.43 7.3 0.74 0.131 0.0884 2.34e-05 181 -0.253 9460000 1 0 0.777 0.000404 135 PRS_PLINK_1.58489319246107e.102 TRUE 433.11 Occlusion of cerebral arteries, with cerebral infarction Both 1 2 8 circulatory system red 2, 1 1, 1 1, 0 1, 1 1, 0 -1.41 2350 1 0 0.245 0.0567 1.83e+16 -0.0135 27.9 1 0 0.987 0.917 1.2 PRS_PLINK_1.58489319246107e.102 TRUE 433.12 Cerebral atherosclerosis Both 0 1 8 circulatory system red 1, 0 PRS_PLINK_1.58489319246107e.102 TRUE 433.2 Occlusion of cerebral arteries Both 2 24 8 circulatory system red 24, 2 6, 1 6, 1 6, 0 6, 0 -0.474 0.791 0.548 0.261 0.622 0.0812 6.83 -0.528 1.72 0.759 0.12 0.589 0.00562 43.9 -0.552 1.68 0.742 0.13 0.576 0.0182 99 -1.33 2.28 0.561 0.251 0.265 0.0037 42.4 PRS_PLINK_1.58489319246107e.102 TRUE 433.21 Cerebral artery occlusion, with cerebral infarction Both 2 23 8 circulatory system red 23, 2 6, 1 6, 1 5, 0 6, 0 -0.46 0.791 0.561 0.251 0.632 0.0797 6.75 -0.528 1.72 0.759 0.12 0.589 0.00562 43.9 -0.746 1.93 0.699 0.156 0.474 0.00671 69.8 -1.33 2.28 0.561 0.251 0.265 0.0037 42.4 PRS_PLINK_1.58489319246107e.102 TRUE 433.3 Cerebral ischemia Both 5 25 8 circulatory system red 25, 5 7, 1 6, 2 6, 1 6, 0 -0.28 0.563 0.619 0.208 0.756 0.252 2.57 0.944 1.64 0.566 0.247 2.57 0.123 891 0.0805 1.56 0.959 0.018 1.08 0.0364 430 -1.44 2.24 0.52 0.284 0.236 0.00224 91.6 PRS_PLINK_1.58489319246107e.102 TRUE 433.31 Transient cerebral ischemia Both 4 21 8 circulatory system red 21, 4 6, 0 5, 3 5, 0 5, 0 -0.218 0.66 0.741 0.13 0.804 0.116 32 0.344 1.56 0.826 0.083 1.41 0.0621 141 PRS_PLINK_1.58489319246107e.102 TRUE 433.5 Cerebral aneurysm Both 1 8 8 circulatory system red 8, 1 2, 1 2, 0 2, 0 2, 0 0.0313 4.45 0.994 0.002 1.03 0.956 2.05 0.0225 695 1 0 1.02 0.673 1.21 0.0415 7150 1 0 1.04 0.236 5.11 -0.135 12000 1 0 0.874 0.0433 8.32 PRS_PLINK_1.58489319246107e.102 TRUE 433.6 Acute, but ill-defined cerebrovascular disease Both 0 6 8 circulatory system red 6, 0 2 1 1 2 PRS_PLINK_1.58489319246107e.102 TRUE 433.8 Late effects of cerebrovascular disease Both 1 7 8 circulatory system red 7, 1 2, 0 2, 1 1, 0 2, 0 -0.519 377 0.999 0 0.595 0.501 0.704 0.23 3740 1 0 1.26 0.474 1.33 PRS_PLINK_1.58489319246107e.102 TRUE 440 Atherosclerosis Both 2 19 8 circulatory system red 19, 2 5, 1 5, 0 4, 0 5, 1 0.0773 0.989 0.938 0.028 1.08 0.119 23.7 -0.00963 1.84 0.996 0.002 0.99 0.0462 30.7 0.408 3.38 0.904 0.044 1.5 0.00274 6.8e+07 3.36 4.38 0.443 0.354 28.9 0.0576 5540000 PRS_PLINK_1.58489319246107e.102 TRUE 440.1 Atherosclerosis of renal artery Both 0 2 8 circulatory system red 2, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 440.2 Atherosclerosis of the extremities Both 2 16 8 circulatory system red 16, 2 4, 1 4, 0 4, 0 4, 1 0.4 1.12 0.722 0.141 1.49 0.137 79.6 1.72 3.46 0.619 0.208 5.58 0.0539 1700 -0.183 2.43 0.94 0.027 0.833 0.02 34.9 1.95 7.09 0.783 0.106 7.02 0.00488 9330 PRS_PLINK_1.58489319246107e.102 TRUE 440.21 Atherosclerosis of native arteries of the extremities with ulceration or gangrene Both 0 9 8 circulatory system red 9, 0 3 2 2 2 PRS_PLINK_1.58489319246107e.102 TRUE 440.22 Atherosclerosis of native arteries of the extremities with intermittent claudication Both 2 11 8 circulatory system red 11, 2 3, 1 3, 0 2, 1 3, 0 0.423 1.25 0.736 0.133 1.53 0.43 1.68 -0.164 472 1 0 0.849 0.435 0.886 -0.197 499 1 0 0.821 0.248 1.22 0.0324 308 1 0 1.03 0.773 2.63 PRS_PLINK_1.58489319246107e.102 TRUE 440.9 Atherosclerosis of aorta Both 1 3 8 circulatory system red 3, 1 1, 1 1, 0 1, 0 1, 1 -0.314 5110 1 0 0.73 0.121 2.69 0.426 731000 1 0 1.53 0.00372 631 0.367 297000 1 0 1.44 0.00806 259 PRS_PLINK_1.58489319246107e.102 TRUE 441 Vascular insufficiency of intestine Both 0 8 8 circulatory system red 8, 0 2 2 2 2 PRS_PLINK_1.58489319246107e.102 TRUE 441.1 Acute vascular insufficiency of intestine Both 0 3 8 circulatory system red 3, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 442 Other aneurysm Both 4 21 8 circulatory system red 21, 4 5, 1 5, 0 5, 0 5, 3 0.0226 0.653 0.972 0.012 1.02 0.954 4.12 -2.09 2.9 0.472 0.326 0.124 0.109 4.49 -3.26 5.54 0.556 0.255 0.0385 2.44e-06 142 -0.281 2.29 0.902 0.045 0.755 0.0199 51 PRS_PLINK_1.58489319246107e.102 TRUE 442.1 Aortic aneurysm Both 3 13 8 circulatory system red 13, 3 3, 0 3, 0 3, 0 3, 3 0.926 1.34 0.49 0.31 2.52 0.12 246 -1.69 166 0.992 0.004 0.185 3.16e-08 1140000 PRS_PLINK_1.58489319246107e.102 TRUE 442.11 Abdominal aortic aneurysm Both 1 4 8 circulatory system red 4, 1 1, 0 1, 0 1, 0 1, 1 -0.0236 2440 1 0 0.977 0.337 2.62 0.0583 42.2 0.999 0 1.06 0.852 1.08 PRS_PLINK_1.58489319246107e.102 TRUE 442.3 Aneurysm of artery of lower extremity Both 0 2 8 circulatory system red 2, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 442.4 Arterial dissection Both 1 0 8 circulatory system red 0, 1 PRS_PLINK_1.58489319246107e.102 TRUE 442.8 Aneurysm of other specified artery Both 0 3 8 circulatory system red 3, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 443 Peripheral vascular disease Both 3 28 8 circulatory system red 28, 3 6, 2 7, 0 7, 1 7, 0 -0.471 0.713 0.509 0.293 0.624 0.0647 2.36 -1.5 1.53 0.328 0.484 0.224 0.00155 2.16 1.67 3.13 0.593 0.227 5.32 0.00274 14800 -0.944 2 0.638 0.195 0.389 0.0141 85.9 PRS_PLINK_1.58489319246107e.102 TRUE 443.1 Raynaud's syndrome Both 1 7 8 circulatory system red 7, 1 1, 0 2, 1 1, 0 2, 0 0.431 338 0.999 0 1.54 0.958 3.84 -5.41 6.34e+08 1 0 0.00448 6.57e-15 3.02e+20 PRS_PLINK_1.58489319246107e.102 TRUE 443.7 Peripheral angiopathy in diseases classified elsewhere Both 1 5 8 circulatory system red 5, 1 2, 0 1, 0 1, 1 1, 0 0.00961 7890000 1 0 1.01 0.458 2.51 0.0572 39200 1 0 1.06 0.118 792000 PRS_PLINK_1.58489319246107e.102 TRUE 443.8 Other specified peripheral vascular diseases Both 3 27 8 circulatory system red 27, 3 6, 2 7, 0 6, 1 7, 0 -0.473 0.714 0.508 0.294 0.623 0.0637 2.36 -1.5 1.53 0.328 0.484 0.224 0.00155 2.16 1.68 3.15 0.593 0.227 5.38 0.00284 15200 -0.944 2 0.638 0.195 0.389 0.0141 85.9 PRS_PLINK_1.58489319246107e.102 TRUE 443.9 Peripheral vascular disease, unspecified Both 3 23 8 circulatory system red 23, 3 5, 2 6, 0 5, 1 6, 0 -1.14 1.08 0.289 0.539 0.319 0.000329 2.02 -1.44 1.62 0.374 0.427 0.237 0.000129 2.18 -1.42 2.96 0.633 0.199 0.242 0.000309 397 -1.01 2.71 0.71 0.149 0.366 0.339 0.398 PRS_PLINK_1.58489319246107e.102 TRUE 444 Arterial embolism and thrombosis Both 1 13 8 circulatory system red 13, 1 3, 0 3, 0 3, 1 3, 0 0.178 1.24 0.886 0.053 1.19 0.0272 21.1 0.165 503 1 0 1.18 0.783 2.1 PRS_PLINK_1.58489319246107e.102 TRUE 444.1 Arterial embolism and thrombosis of lower extremity artery Both 0 4 8 circulatory system red 4, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 444.2 Embolism and thrombosis of abdominal aorta Both 0 1 8 circulatory system red 1, 0 PRS_PLINK_1.58489319246107e.102 TRUE 446 Polyarteritis nodosa and allied conditions Both 1 10 8 circulatory system red 10, 1 2, 0 2, 0 2, 0 3, 1 0.56 6.2 0.928 0.032 1.75 4.38e-05 43200 -0.0719 2130 1 0 0.931 0.0572 5.38 PRS_PLINK_1.58489319246107e.102 TRUE 446.4 Wegener's granulomatosis Both 0 3 8 circulatory system red 3, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 446.5 Giant cell arteritis Both 1 1 8 circulatory system red 1, 1 36.6 2.25e+12 1 0 7.64e+15 1.33e-50 8.09e+85 PRS_PLINK_1.58489319246107e.102 TRUE 446.9 Arteritis NOS Both 1 4 8 circulatory system red 4, 1 1, 0 1, 0 1, 1 1, 0 -0.237 2300 1 0 0.789 0.291 1.69 PRS_PLINK_1.58489319246107e.102 TRUE 447 Other disorders of arteries and arterioles Both 3 23 8 circulatory system red 23, 3 5, 1 6, 0 5, 1 6, 1 -0.271 0.608 0.656 0.183 0.763 0.201 2.72 -0.784 1.94 0.687 0.163 0.457 0.000268 7.28 -0.384 2.16 0.859 0.066 0.681 0.0166 16.8 -1.5 2.06 0.468 0.33 0.223 0.00153 4.18 PRS_PLINK_1.58489319246107e.102 TRUE 447.1 Stricture of artery Both 1 5 8 circulatory system red 5, 1 2, 0 1, 1 1, 0 1, 0 -0.000354 97.5 1 0 1 0.973 1.06 -3.66e-06 2010 1 0 1 0.781 1.27 PRS_PLINK_1.58489319246107e.102 TRUE 447.7 Aortic ectasia Both 0 11 8 circulatory system red 11, 0 2 3 2 3 PRS_PLINK_1.58489319246107e.102 TRUE 448 Disease of capillaries Both 1 13 8 circulatory system red 13, 1 4, 0 3, 0 3, 1 3, 0 0.159 1.01 0.875 0.058 1.17 0.207 9.32 4.84 3530 0.999 0 126 2.38e-07 1470000 PRS_PLINK_1.58489319246107e.102 TRUE 450 Noninfectious disorders of lymphatic channels Both 1 22 8 circulatory system red 22, 1 6, 0 5, 0 5, 0 6, 1 0.0957 0.715 0.893 0.049 1.1 0.213 8.15 1.29 4.16 0.756 0.122 3.65 0.00452 3620 PRS_PLINK_1.58489319246107e.102 TRUE 451 Phlebitis and thrombophlebitis Both 3 6 8 circulatory system red 6, 3 2, 1 1, 1 1, 0 2, 1 -0.256 922 1 0 0.774 0.193 0.523 -0.639 10600 1 0 0.528 0.296 3.75 -0.411 10500 1 0 0.663 0.027 2.78 -0.224 1050 1 0 0.8 0.283 1.04 PRS_PLINK_1.58489319246107e.102 TRUE 451.2 Phlebitis and thrombophlebitis of lower extremities Both 2 2 8 circulatory system red 2, 2 1, 1 1, 1 1, 1 1, 1 -8.89 1.2e+09 1 0 0.000137 2.13e-17 24.6 -0.00939 584 1 0 0.991 0.808 1.1 PRS_PLINK_1.58489319246107e.102 TRUE 452 Other venous embolism and thrombosis Both 5 30 8 circulatory system red 30, 5 8, 3 7, 0 7, 1 8, 1 -1.07 0.684 0.119 0.924 0.345 0.014 1.09 -0.632 1.89 0.737 0.132 0.531 2.72e-05 13.9 -2.06 1.71 0.229 0.64 0.128 0.00288 1.88 -2.88 2.03 0.156 0.806 0.0561 1.4e-07 1.37 PRS_PLINK_1.58489319246107e.102 TRUE 452.1 Iatrogenic pulmonary embolism and infarction Both 0 6 8 circulatory system red 6, 0 2 1 1 2 PRS_PLINK_1.58489319246107e.102 TRUE 452.2 Deep vein thrombosis [DVT] Both 4 23 8 circulatory system red 23, 4 6, 2 6, 0 5, 1 6, 1 -1 0.778 0.199 0.702 0.368 0.016 1.51 0.478 5.38 0.929 0.032 1.61 1.73e-10 20400 -1.46 1.75 0.403 0.394 0.231 4.55e-05 3.4 -0.424 1.6 0.791 0.102 0.654 0.166 32.6 PRS_PLINK_1.58489319246107e.102 TRUE 452.8 Postphlebitic syndrome Both 0 1 8 circulatory system red 1, 0 PRS_PLINK_1.58489319246107e.102 TRUE 453 Chronic venous hypertension Both 0 3 8 circulatory system red 3, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 454 Varicose veins Both 5 23 8 circulatory system red 23, 5 6, 0 6, 0 5, 3 6, 2 0.77 1.02 0.453 0.344 2.16 0.0274 2900000 0.933 2.55 0.715 0.146 2.54 0.000736 1890000 0.567 2.22 0.799 0.098 1.76 0.0408 105 PRS_PLINK_1.58489319246107e.102 TRUE 454.1 Varicose veins of lower extremity Both 4 19 8 circulatory system red 19, 4 5, 0 5, 0 4, 3 5, 1 -0.124 1.12 0.912 0.04 0.883 0.0162 112 1.02 2.67 0.703 0.153 2.77 0.0598 6e+07 0.833 12.6 0.947 0.024 2.3 0.00112 6700 PRS_PLINK_1.58489319246107e.102 TRUE 454.11 Varicose veins of lower extremity, symptomtic Both 4 15 8 circulatory system red 15, 4 4, 0 4, 0 3, 3 4, 1 -0.134 1.58 0.932 0.03 0.874 0.0983 43.5 0.162 44.5 0.997 0.001 1.18 0.218 28.5 0.585 2290000 1 0 1.79 0.248 7.55 PRS_PLINK_1.58489319246107e.102 TRUE 455 Hemorrhoids Both 16 28 8 circulatory system red 28, 16 7, 4 7, 2 7, 6 7, 4 0.421 0.512 0.411 0.386 1.52 0.586 4.45 0.0848 1.39 0.952 0.022 1.09 0.00487 45.7 0.665 1.13 0.556 0.255 1.95 0.311 83 1.53 2.11 0.467 0.33 4.64 0.111 207000 PRS_PLINK_1.58489319246107e.102 TRUE 456 Chronic venous insufficiency [CVI] Both 8 24 8 circulatory system red 24, 8 6, 0 6, 0 6, 5 6, 2 -0.723 0.895 0.419 0.377 0.485 0.0137 3.84 1.7 1.96 0.384 0.416 5.5 0.273 243000 -0.574 3.35 0.864 0.064 0.563 4.89e-05 129000 PRS_PLINK_1.58489319246107e.102 TRUE 457 Encounter for long-term (current) use of anticoagulants, antithrombotics, aspirin Both 1 12 8 circulatory system red 12, 1 3, 1 3, 0 3, 0 3, 0 -0.789 1.7 0.643 0.192 0.454 0.0101 10.3 -0.211 914 1 0 0.81 0.438 1.7 0.0417 663 1 0 1.04 0.805 1.42 0.0244 78 1 0 1.02 0.915 1.34 PRS_PLINK_1.58489319246107e.102 TRUE 457.2 Encounter for long-term (current) use of antiplatelets/antithrombotics Both 0 2 8 circulatory system red 2, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 457.3 Encounter for long-term (current) use of aspirin Both 1 11 8 circulatory system red 11, 1 3, 1 3, 0 2, 0 3, 0 -0.672 1.77 0.703 0.153 0.51 0.0137 202 -0.211 914 1 0 0.81 0.438 1.7 0.822 5690 1 0 2.27 0.415 3.38 -0.123 6800 1 0 0.884 0.178 3.76 PRS_PLINK_1.58489319246107e.102 TRUE 458 Hypotension Both 3 38 8 circulatory system red 38, 3 10, 0 9, 0 9, 0 10, 3 1.58 0.996 0.113 0.945 4.84 0.54 2730 0.141 1.69 0.934 0.03 1.15 0.0453 1.25e+09 PRS_PLINK_1.58489319246107e.102 TRUE 458.1 Orthostatic hypotension Both 0 19 8 circulatory system red 19, 0 5 5 4 5 PRS_PLINK_1.58489319246107e.102 TRUE 458.2 Iatrogenic hypotension Both 0 12 8 circulatory system red 12, 0 3 3 3 3 PRS_PLINK_1.58489319246107e.102 TRUE 458.9 Hypotension NOS Both 3 35 8 circulatory system red 35, 3 9, 0 9, 0 8, 0 9, 3 1.68 1 0.095 1.022 5.35 0.719 533 1.36 2.49 0.584 0.234 3.9 0.0609 87700000 PRS_PLINK_1.58489319246107e.102 TRUE 459 Other disorders of circulatory system Both 9 49 8 circulatory system red 49, 9 13, 4 12, 1 12, 0 12, 3 -0.87 0.53 0.1 0.998 0.419 0.0841 1.18 -3.37 1.88 0.0726 1.139 0.0344 0.00465 0.624 -1.31 1.43 0.361 0.442 0.27 0.000599 3.32 -1.42 1.33 0.288 0.541 0.242 0.00264 2.72 PRS_PLINK_1.58489319246107e.102 TRUE 459.1 Hemorrhage NOS Both 0 11 8 circulatory system red 11, 0 3 3 2 3 PRS_PLINK_1.58489319246107e.102 TRUE 459.7 Blood vessel replaced Both 1 12 8 circulatory system red 12, 1 3, 0 3, 0 3, 0 3, 1 0.354 1.68 0.833 0.079 1.43 0.0979 43.7 -0.0146 31.6 1 0 0.985 0.95 1.02 PRS_PLINK_1.58489319246107e.102 TRUE 459.9 Circulatory disease NEC Both 9 46 8 circulatory system red 46, 9 12, 4 11, 1 11, 1 12, 2 -0.908 0.531 0.0872 1.06 0.403 0.107 1.11 -2.48 1.53 0.105 0.979 0.0837 0.00048 1.07 -0.822 1.33 0.536 0.271 0.439 0.0127 9.54 -1.35 1.27 0.287 0.542 0.26 0.012 2.59 PRS_PLINK_1.58489319246107e.102 TRUE 464 Acute sinusitis Both 11 34 9 respiratory coral4 34, 11 8, 1 8, 1 8, 4 9, 5 0.14 0.427 0.743 0.129 1.15 0.491 2.74 -0.0838 1.87 0.964 0.016 0.92 0.00526 34.6 1.41 1.61 0.38 0.42 4.12 0.278 449 0.288 1.26 0.819 0.087 1.33 0.16 14.8 PRS_PLINK_1.58489319246107e.102 TRUE 465 Acute upper respiratory infections of multiple or unspecified sites Both 24 36 9 respiratory coral4 36, 24 8, 5 9, 5 9, 7 9, 7 0.173 0.294 0.556 0.255 1.19 0.702 2.07 0.299 1.14 0.793 0.101 1.35 0.147 15.5 0.64 0.945 0.498 0.303 1.9 0.39 11.1 0.0561 1 0.955 0.02 1.06 0.176 6.95 PRS_PLINK_1.58489319246107e.102 TRUE 465.2 Acute pharyngitis Both 17 37 9 respiratory coral4 37, 17 9, 4 9, 2 9, 5 9, 6 0.0651 0.312 0.835 0.078 1.07 0.607 1.94 -0.226 1.17 0.846 0.072 0.798 0.0826 9.75 0.52 1.06 0.625 0.204 1.68 0.279 19.7 1.11 1.31 0.395 0.403 3.05 0.359 65.7 PRS_PLINK_1.58489319246107e.102 TRUE 465.4 Acute laryngitis and tracheitis Both 0 3 9 respiratory coral4 3, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 470 Septal Deviations/Turbinate Hypertrophy Both 2 22 9 respiratory coral4 22, 2 6, 0 5, 1 5, 0 6, 1 0.186 0.53 0.725 0.139 1.2 0.464 22200 -0.754 3.53 0.831 0.08 0.471 8.97e-06 1610000 0.384 1.65 0.816 0.088 1.47 0.00957 108 PRS_PLINK_1.58489319246107e.102 TRUE 471 Nasal polyps Both 2 5 9 respiratory coral4 5, 2 2, 0 1, 0 1, 0 1, 2 0.268 221 0.999 0 1.31 1.29 2.33 0.0501 1970 1 0 1.05 0.429 2.72 PRS_PLINK_1.58489319246107e.102 TRUE 472 Chronic pharyngitis and nasopharyngitis Both 5 23 9 respiratory coral4 23, 5 6, 0 6, 1 5, 0 6, 4 0.545 0.748 0.466 0.331 1.72 0.343 39.1 0.572 2.4 0.811 0.091 1.77 0.0013 618 0.489 1.73 0.778 0.109 1.63 0.0449 105 PRS_PLINK_1.58489319246107e.102 TRUE 473 Diseases of the larynx and vocal cords Both 5 26 9 respiratory coral4 26, 5 7, 0 6, 1 6, 1 7, 2 -0.181 0.561 0.748 0.126 0.835 0.152 2.8 -0.332 2.26 0.883 0.054 0.717 0.00395 273 0.216 2.03 0.915 0.038 1.24 0.0412 221 -0.0972 1.59 0.951 0.022 0.907 0.0107 27.6 PRS_PLINK_1.58489319246107e.102 TRUE 473.1 Chronic laryngitis Both 0 1 9 respiratory coral4 1, 0 PRS_PLINK_1.58489319246107e.102 TRUE 473.3 Paralysis/spasm of vocal cords or larynx Both 1 4 9 respiratory coral4 4, 1 1, 0 1, 0 1, 1 1, 0 -0.333 300 0.999 0 0.717 7.62e-06 698000 0.00323 55.7 1 0 1 0.911 1.09 PRS_PLINK_1.58489319246107e.102 TRUE 473.4 Voice disturbance Both 3 19 9 respiratory coral4 19, 3 5, 0 5, 1 4, 0 5, 1 -0.249 0.611 0.684 0.165 0.779 0.14 2.58 0.0159 3.72 0.997 0.001 1.02 0.00311 710 0.16 3.52 0.964 0.016 1.17 0.00591 3200 PRS_PLINK_1.58489319246107e.102 TRUE 474 Acute and chronic tonsillitis Both 3 13 9 respiratory coral4 13, 3 4, 0 3, 0 3, 2 3, 1 0.472 0.683 0.489 0.31 1.6 0.402 6.75 -0.269 15800000 1 0 0.764 0.00225 242 0.25 515 1 0 1.28 0.961 5.76 PRS_PLINK_1.58489319246107e.102 TRUE 474.1 Acute tonsillitis Both 1 8 9 respiratory coral4 8, 1 2, 0 2, 0 2, 0 2, 1 -0.281 111 0.998 0.001 0.755 0.79 2.56 0.143 2700 1 0 1.15 0.13 2.53 PRS_PLINK_1.58489319246107e.102 TRUE 474.2 Chronic tonsillitis and adenoiditis Both 3 8 9 respiratory coral4 8, 3 2, 0 2, 0 2, 2 2, 1 -0.491 4.02 0.903 0.044 0.612 0.588 0.639 5.17 2.7e+07 1 0 176 1.35e-10 1.07e+17 0.109 1660 1 0 1.12 0.543 2.66 PRS_PLINK_1.58489319246107e.102 TRUE 475 Chronic sinusitis Both 11 31 9 respiratory coral4 31, 11 8, 0 8, 6 7, 1 8, 4 0.0587 0.396 0.882 0.054 1.06 0.507 2.21 2.13 1.72 0.217 0.663 8.39 0.644 26200 0.0913 1.94 0.963 0.017 1.1 0.0296 81.3 0.74 1.72 0.667 0.176 2.1 0.0103 852 PRS_PLINK_1.58489319246107e.102 TRUE 475.9 Postnasal drip Both 4 7 9 respiratory coral4 7, 4 2, 0 2, 0 1, 4 2, 0 1.31 3.06 0.669 0.175 3.7 0.0539 551 -1.45 7410 1 0 0.234 0.000144 3560 PRS_PLINK_1.58489319246107e.102 TRUE 476 Allergic rhinitis Both 24 32 9 respiratory coral4 32, 24 8, 0 8, 5 8, 10 8, 8 0.298 0.313 0.341 0.467 1.35 0.772 2.46 2.28 1.69 0.178 0.751 9.79 0.658 942 2.97 1.75 0.0898 1.047 19.5 1.28 3070 1.72 1.42 0.225 0.647 5.56 0.579 598 PRS_PLINK_1.58489319246107e.102 TRUE 477 Epistaxis or throat hemorrhage Both 1 11 9 respiratory coral4 11, 1 3, 0 3, 0 2, 1 3, 0 0.467 1.58 0.767 0.115 1.6 1.51 1.66 -0.05 966 1 0 0.951 0.397 2.28 PRS_PLINK_1.58489319246107e.102 TRUE 478 Throat pain Both 1 5 9 respiratory coral4 5, 1 2, 0 1, 1 1, 0 1, 0 0.437 643 0.999 0 1.55 0.0395 73.2 0.17 1590 1 0 1.19 0.67 1.22 PRS_PLINK_1.58489319246107e.102 TRUE 479 Other upper respiratory disease Both 11 32 9 respiratory coral4 32, 11 8, 1 8, 3 8, 2 8, 5 0.484 0.432 0.262 0.582 1.62 0.769 4.34 1.49 1.58 0.345 0.462 4.43 0.353 15500 -0.287 2.02 0.887 0.052 0.751 0.00101 133 0.571 1.49 0.701 0.154 1.77 0.0778 85.5 PRS_PLINK_1.58489319246107e.102 TRUE 480 Pneumonia Both 13 43 9 respiratory coral4 43, 13 11, 1 11, 3 10, 3 11, 5 0.189 0.388 0.626 0.204 1.21 0.559 2.75 0.687 1.08 0.526 0.279 1.99 0.306 24.5 2.11 1.88 0.262 0.582 8.25 0.341 2210 0.216 1.43 0.88 0.056 1.24 0.0604 660 PRS_PLINK_1.58489319246107e.102 TRUE 480.1 Bacterial pneumonia Both 5 13 9 respiratory coral4 13, 5 4, 1 3, 0 3, 2 3, 2 0.196 1.65 0.906 0.043 1.22 0.0714 1.64 -0.0464 2180 1 0 0.955 0.383 1.54 3.51 15.4 0.82 0.086 33.6 27.6 41.3 -3.98 7.78 0.608 0.216 0.0186 0.0137 1110 PRS_PLINK_1.58489319246107e.102 TRUE 480.11 Pneumococcal pneumonia Both 3 5 9 respiratory coral4 5, 3 2, 1 1, 1 1, 0 1, 1 -0.417 33.5 0.99 0.004 0.659 0.244 0.538 -0.0405 511 1 0 0.96 6.55e-07 609 -0.0303 2680 1 0 0.97 0.688 1.12 0.0569 3610 1 0 1.06 0.801 2.14 PRS_PLINK_1.58489319246107e.102 TRUE 480.12 Pseudomonal pneumonia Both 1 2 9 respiratory coral4 2, 1 1, 0 1, 1 1, 0 1, 1 -0.0157 103 1 0 0.984 0.837 1.23 -0.0131 86.3 1 0 0.987 0.896 1.08 PRS_PLINK_1.58489319246107e.102 TRUE 480.2 Viral pneumonia Both 1 7 9 respiratory coral4 7, 1 2, 0 2, 0 1, 1 2, 0 -0.00209 76.8 1 0 0.998 0.922 1.07 -0.147 8560 1 0 0.863 0.0293 17.2 PRS_PLINK_1.58489319246107e.102 TRUE 480.3 Pneumonia due to fungus (mycoses) Both 2 3 9 respiratory coral4 3, 2 1, 1 1, 0 1, 1 1, 1 -0.00014 1720 1 0 1 0.572 1.69 0.0191 327 1 0 1.02 0.864 1.25 -5.47e-05 2770 1 0 1 0.572 1.72 PRS_PLINK_1.58489319246107e.102 TRUE 480.5 Bronchopneumonia and lung abscess Both 0 1 9 respiratory coral4 1, 0 PRS_PLINK_1.58489319246107e.102 TRUE 481 Influenza Both 4 22 9 respiratory coral4 22, 4 6, 0 5, 1 5, 1 6, 2 0.364 0.797 0.648 0.188 1.44 0.135 45.1 0.00103 2.08 1 0 1 0.00254 24.6 0.0656 3.61 0.986 0.006 1.07 3.72e-07 783000 0.37 3.75 0.922 0.035 1.45 8.31e-07 745 PRS_PLINK_1.58489319246107e.102 TRUE 483 Acute bronchitis and bronchiolitis Both 9 35 9 respiratory coral4 35, 9 9, 0 9, 1 8, 4 9, 4 0.339 0.433 0.433 0.363 1.4 0.649 3.42 0.359 1.69 0.831 0.08 1.43 0.00274 2330 2.93 1.92 0.126 0.899 18.7 0.98 1.81e+09 0.298 1.59 0.852 0.07 1.35 0.0483 58.7 PRS_PLINK_1.58489319246107e.102 TRUE 495 Asthma Both 15 45 9 respiratory coral4 45, 15 11, 0 11, 4 11, 3 11, 8 0.593 0.384 0.122 0.913 1.81 0.913 4.21 2.49 1.55 0.109 0.962 12 0.969 6280 0.511 1.68 0.762 0.118 1.67 9.7e-05 200 1.6 1.32 0.225 0.648 4.94 0.49 455 PRS_PLINK_1.58489319246107e.102 TRUE 495.1 Chronic obstructive asthma Both 1 3 9 respiratory coral4 3, 1 1, 0 1, 0 1, 1 1, 0 0.16 11500 1 0 1.17 0.316 3.46 -0.00715 30.6 1 0 0.993 0.898 1.1 PRS_PLINK_1.58489319246107e.102 TRUE 495.11 Chronic obstructive asthma with exacerbation Both 1 3 9 respiratory coral4 3, 1 1, 0 1, 0 1, 1 1, 0 -0.0297 1240 1 0 0.971 0.726 1.25 -0.000392 46.9 1 0 1 0.936 1.06 PRS_PLINK_1.58489319246107e.102 TRUE 495.2 Asthma with exacerbation Both 7 26 9 respiratory coral4 26, 7 6, 0 6, 1 6, 1 7, 5 0.467 0.499 0.349 0.457 1.59 0.677 5.42 -0.737 2.37 0.756 0.121 0.479 0.00155 25.2 -0.0728 1.82 0.968 0.014 0.93 0.055 41.7 0.763 1.63 0.64 0.194 2.15 0.146 378 PRS_PLINK_1.58489319246107e.102 TRUE 496 Chronic airway obstruction Both 7 31 9 respiratory coral4 31, 7 7, 0 8, 2 7, 1 8, 4 0.298 0.421 0.479 0.319 1.35 0.631 3.53 1.18 1.54 0.442 0.355 3.27 0.302 801 0.197 1.62 0.903 0.044 1.22 0.00977 23.2 1.16 1.72 0.5 0.301 3.2 0.192 7.63e+09 PRS_PLINK_1.58489319246107e.102 TRUE 496.1 Emphysema Both 1 12 9 respiratory coral4 12, 1 3, 1 3, 0 3, 0 3, 0 -0.306 1.18 0.795 0.1 0.736 0.0765 7.1 0.0971 537 1 0 1.1 0.2 4.61 0.187 1710 1 0 1.21 0.514 3.79 1.47 14900000 1 0 4.36 0.0097 5620 PRS_PLINK_1.58489319246107e.102 TRUE 496.2 Chronic bronchitis Both 3 22 9 respiratory coral4 22, 3 5, 0 5, 0 5, 0 6, 3 0.785 0.651 0.228 0.642 2.19 0.74 55.9 -1.38 3.86 0.72 0.143 0.25 2.08e-05 1470 PRS_PLINK_1.58489319246107e.102 TRUE 496.21 Obstructive chronic bronchitis Both 2 20 9 respiratory coral4 20, 2 4, 0 5, 0 5, 0 5, 2 0.43 0.644 0.504 0.297 1.54 0.348 14.9 -0.485 6.24 0.938 0.028 0.616 2.96e-05 10200 PRS_PLINK_1.58489319246107e.102 TRUE 496.3 Bronchiectasis Both 4 2 9 respiratory coral4 2, 4 1, 1 1, 3 1, 1 1, 3 -0.104 116 0.999 0 0.901 0.394 1.11 0.432 328 0.999 0 1.54 0.614 5.32 PRS_PLINK_1.58489319246107e.102 TRUE 497 Bronchitis Both 5 28 9 respiratory coral4 28, 5 6, 0 7, 0 7, 2 7, 3 0.581 0.561 0.301 0.522 1.79 0.54 11.1 0.58 1.44 0.688 0.162 1.79 0.0621 181 -0.0832 1.92 0.965 0.015 0.92 0.000123 150 PRS_PLINK_1.58489319246107e.102 TRUE 498 Acute bronchospasm Both 2 7 9 respiratory coral4 7, 2 2, 0 2, 0 1, 0 2, 2 0.304 8530000 1 0 1.35 0.0199 254 -2.5 3370 0.999 0 0.082 1.1e-10 2250000 PRS_PLINK_1.58489319246107e.102 TRUE 499 Cystic fibrosis Both 2 5 9 respiratory coral4 5, 2 2, 0 1, 0 1, 0 1, 2 -0.858 3910 1 0 0.424 0.00636 20.8 -0.000665 22.7 1 0 0.999 0.985 1.02 PRS_PLINK_1.58489319246107e.102 TRUE 500 Lung disease due to external agents Both 1 2 9 respiratory coral4 2, 1 1, 1 1, 1 1, 1 1, 1 0.049 52.1 0.999 0 1.05 0.915 1.19 PRS_PLINK_1.58489319246107e.102 TRUE 500.1 Extrinsic allergic alveolitis Both 1 1 9 respiratory coral4 1, 1 0.0198 120 1 0 1.02 0.763 1.36 PRS_PLINK_1.58489319246107e.102 TRUE 501 Pneumonitis due to inhalation of food or vomitus Both 0 10 9 respiratory coral4 10, 0 3 2 2 3 PRS_PLINK_1.58489319246107e.102 TRUE 502 Postinflammatory pulmonary fibrosis Both 2 7 9 respiratory coral4 7, 2 1, 1 2, 0 1, 1 2, 0 -0.0691 193 1 0 0.933 0.0739 24.2 -8.36 22500 1 0 0.000234 3.43e-13 2.31e+16 0.0127 18.7 0.999 0 1.01 0.78 1.33 0.472 8940000 1 0 1.6 0.00752 141 PRS_PLINK_1.58489319246107e.102 TRUE 503 Pulmonary congestion and hypostasis Both 0 11 9 respiratory coral4 11, 0 3 3 2 3 PRS_PLINK_1.58489319246107e.102 TRUE 504 Other alveolar and parietoalveolar pneumonopathy Both 2 3 9 respiratory coral4 3, 2 1, 1 1, 1 1, 1 1, 1 -0.0947 749 1 0 0.91 0.0121 3.21 PRS_PLINK_1.58489319246107e.102 TRUE 504.1 Idiopathic fibrosing alveolitis Both 2 1 9 respiratory coral4 1, 2 0.0251 51.6 1 0 1.03 0.871 1.1 PRS_PLINK_1.58489319246107e.102 TRUE 505 Other pulmonary inflamation or edema Both 4 19 9 respiratory coral4 19, 4 5, 1 5, 0 4, 2 5, 1 0.127 0.894 0.887 0.052 1.14 0.0608 39.5 0.0255 312 1 0 1.03 0.677 2.01 1.26 2.63 0.632 0.2 3.53 0.0507 5000 0.0473 4.34 0.991 0.004 1.05 0.000882 32200 PRS_PLINK_1.58489319246107e.102 TRUE 506 Empyema and pneumothorax Both 2 23 9 respiratory coral4 23, 2 6, 1 6, 0 5, 1 6, 0 -0.302 0.814 0.711 0.148 0.74 0.0164 16.9 0.0172 2.34 0.994 0.003 1.02 0.00627 2280 0.26 2.02 0.898 0.047 1.3 0.0323 1240 -1.07 2.87 0.709 0.149 0.342 0.000756 73.5 PRS_PLINK_1.58489319246107e.102 TRUE 507 Pleurisy; pleural effusion Both 1 28 9 respiratory coral4 28, 1 6, 0 7, 0 7, 0 7, 1 0.214 0.602 0.722 0.141 1.24 0.199 13.5 0.0861 1.84 0.963 0.017 1.09 0.0373 54.9 PRS_PLINK_1.58489319246107e.102 TRUE 508 Pulmonary collapse; interstitial and compensatory emphysema Both 1 25 9 respiratory coral4 25, 1 7, 0 6, 0 6, 1 6, 0 -0.0692 0.698 0.921 0.036 0.933 0.103 17.9 0.317 3.03 0.917 0.038 1.37 6.1e-06 28000 PRS_PLINK_1.58489319246107e.102 TRUE 509 Respiratory failure, insufficiency, arrest Both 5 37 9 respiratory coral4 37, 5 9, 2 9, 0 9, 2 9, 1 -0.385 0.55 0.484 0.315 0.681 0.129 2.19 -2.34 1.89 0.215 0.668 0.0965 4.12e-06 1.75 -0.612 1.38 0.658 0.182 0.542 0.0201 33.4 -0.727 1.58 0.647 0.189 0.484 0.000199 13 PRS_PLINK_1.58489319246107e.102 TRUE 509.1 Respiratory failure Both 1 24 9 respiratory coral4 24, 1 5, 0 6, 0 6, 1 6, 0 0.12 0.64 0.852 0.07 1.13 0.292 16.2 0.951 2.14 0.657 0.183 2.59 0.104 161 PRS_PLINK_1.58489319246107e.102 TRUE 509.2 Respiratory insufficiency Both 0 14 9 respiratory coral4 14, 0 4 3 3 4 PRS_PLINK_1.58489319246107e.102 TRUE 509.3 Pulmonary insufficiency or respiratory failure following trauma and surgery Both 1 13 9 respiratory coral4 13, 1 4, 0 3, 0 3, 0 3, 1 -0.612 1.24 0.621 0.207 0.543 0.0425 3.89 0.0366 556 1 0 1.04 0.414 12.3 PRS_PLINK_1.58489319246107e.102 TRUE 509.8 Dependence on respirator [Ventilator] or supplemental oxygen Both 3 19 9 respiratory coral4 19, 3 4, 1 5, 1 4, 1 5, 0 -0.908 0.769 0.238 0.624 0.403 0.047 1.49 -0.00956 198 1 0 0.99 0.518 1.14 -0.541 6.51 0.934 0.03 0.582 1.54e-05 12900 0.328 5.35 0.951 0.022 1.39 0.00032 5210 PRS_PLINK_1.58489319246107e.102 TRUE 510 Other diseases of lung Both 9 40 9 respiratory coral4 40, 9 9, 0 10, 3 10, 3 10, 3 0.428 0.458 0.35 0.456 1.53 0.679 4.41 0.921 1.6 0.564 0.249 2.51 0.0638 75.2 0.774 1.45 0.593 0.227 2.17 0.153 151000 1.14 1.45 0.431 0.365 3.13 0.283 161 PRS_PLINK_1.58489319246107e.102 TRUE 510.2 Lung transplant Both 0 2 9 respiratory coral4 2, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 512 Other symptoms of respiratory system Both 31 33 9 respiratory coral4 33, 31 8, 5 8, 3 8, 15 8, 8 0.183 0.297 0.539 0.269 1.2 0.701 2.13 -0.799 1.05 0.448 0.349 0.45 0.0563 2.5 0.995 0.861 0.248 0.606 2.7 0.614 14.3 -0.0219 1.07 0.984 0.007 0.978 0.142 6.42 PRS_PLINK_1.58489319246107e.102 TRUE 512.1 Wheezing Both 5 16 9 respiratory coral4 16, 5 3, 0 4, 0 4, 2 4, 3 0.362 0.76 0.634 0.198 1.44 0.4 10.8 -0.0523 1720 1 0 0.949 0.445 2.8 5.6 451 0.99 0.004 269 482 8.83e+10 PRS_PLINK_1.58489319246107e.102 TRUE 512.2 Painful respiration Both 5 25 9 respiratory coral4 25, 5 6, 0 6, 3 6, 1 6, 1 0.0438 0.45 0.922 0.035 1.04 0.463 2.55 0.952 2 0.634 0.198 2.59 0.1 2500000 0.169 2 0.933 0.03 1.18 0.0204 28.8 0.198 1.8 0.913 0.04 1.22 0.0567 35.6 PRS_PLINK_1.58489319246107e.102 TRUE 512.3 Abnormal chest sounds Both 0 3 9 respiratory coral4 3, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 512.7 Shortness of breath Both 14 33 9 respiratory coral4 33, 14 8, 2 8, 1 8, 7 8, 4 0.312 0.362 0.389 0.41 1.37 0.717 2.91 -1.34 1.53 0.379 0.422 0.261 0.0127 3.06 0.934 1.1 0.397 0.401 2.55 0.414 25.4 0.22 1.45 0.879 0.056 1.25 0.0891 27 PRS_PLINK_1.58489319246107e.102 TRUE 512.8 Cough Both 22 33 9 respiratory coral4 33, 22 8, 4 8, 2 8, 10 8, 6 0.143 0.32 0.654 0.184 1.15 0.645 2.12 -0.986 1.26 0.435 0.362 0.373 0.0116 2.83 0.937 1.1 0.395 0.404 2.55 0.382 26.5 0.313 1.3 0.81 0.092 1.37 0.139 22.3 PRS_PLINK_1.58489319246107e.102 TRUE 512.9 Other dyspnea Both 18 33 9 respiratory coral4 33, 18 8, 3 8, 1 8, 8 8, 6 0.207 0.333 0.534 0.272 1.23 0.674 2.38 -1.67 1.49 0.263 0.579 0.189 0.00109 1.9 0.236 1.13 0.835 0.078 1.27 0.163 13.3 0.38 1.12 0.734 0.134 1.46 0.209 12 PRS_PLINK_1.58489319246107e.102 TRUE 513 Respiratory abnormalities Both 21 43 9 respiratory coral4 43, 21 10, 3 11, 1 10, 10 11, 7 0.354 0.329 0.282 0.55 1.42 0.783 2.78 -2.04 1.53 0.184 0.736 0.13 0.000124 1.95 1.25 1.12 0.266 0.575 3.48 0.53 41.9 -0.22 1.02 0.829 0.081 0.802 0.114 5.1 PRS_PLINK_1.58489319246107e.102 TRUE 513.3 Hypoventilation Both 1 10 9 respiratory coral4 10, 1 3, 0 2, 1 2, 0 3, 0 0.529 1.3 0.684 0.165 1.7 0.0574 12.5 0.0705 246 1 0 1.07 0.734 1.33 PRS_PLINK_1.58489319246107e.102 TRUE 513.31 Apnea Both 1 5 9 respiratory coral4 5, 1 2, 0 1, 1 1, 0 1, 0 0.0406 362000 1 0 1.04 0.17 2.88 -0.0511 7370 1 0 0.95 0.268 2.49 PRS_PLINK_1.58489319246107e.102 TRUE 513.32 Orthopnea Both 0 2 9 respiratory coral4 2, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 513.4 Hyperventilation Both 1 2 9 respiratory coral4 2, 1 0, 1 1, 0 0, 1 1, 0 0.0918 71.7 0.999 0 1.1 0.733 1.2 PRS_PLINK_1.58489319246107e.102 TRUE 513.8 Disorders of diaphragm Both 0 3 9 respiratory coral4 3, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 514 Abnormal findings examination of lungs Both 6 41 9 respiratory coral4 41, 6 10, 0 10, 1 10, 2 10, 3 0.553 0.547 0.312 0.506 1.74 0.654 15 0.188 1.61 0.907 0.042 1.21 0.00439 64.6 0.298 1.48 0.84 0.075 1.35 0.000745 69.1 0.89 1.54 0.563 0.249 2.43 0.0113 668 PRS_PLINK_1.58489319246107e.102 TRUE 514.1 Abnormal results of function study of pulmonary system Both 0 2 9 respiratory coral4 2, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 514.2 Solitary pulmonary nodule Both 3 25 9 respiratory coral4 25, 3 7, 0 6, 0 6, 0 6, 3 0.27 0.739 0.714 0.146 1.31 0.0466 17.3 0.34 1.57 0.829 0.082 1.41 0.0138 138 PRS_PLINK_1.58489319246107e.102 TRUE 516 Abnormal sputum Both 3 10 9 respiratory coral4 10, 3 3, 0 2, 0 2, 1 3, 2 0.889 2.41 0.713 0.147 2.43 0.0219 588 1.75 3.3e+07 1 0 5.76 2.78 1010 0.000478 453 1 0 1 0.513 2.11 PRS_PLINK_1.58489319246107e.102 TRUE 516.1 Hemoptysis Both 3 11 9 respiratory coral4 11, 3 3, 0 3, 0 2, 1 3, 2 0.834 2.18 0.703 0.153 2.3 0.0101 693 1.75 3.3e+07 1 0 5.76 2.78 1010 0.000478 453 1 0 1 0.513 2.11 PRS_PLINK_1.58489319246107e.102 TRUE 519 Other diseases of respiratory system, not elsewhere classified Both 8 54 9 respiratory coral4 54, 8 13, 1 13, 1 13, 2 14, 4 1.31 0.691 0.0582 1.235 3.7 1.04 30.2 -0.331 1.25 0.79 0.102 0.718 0.0064 24.2 -0.0594 1.51 0.969 0.014 0.942 1.86e-05 43.6 0.918 1.61 0.568 0.246 2.5 0.0646 1510 PRS_PLINK_1.58489319246107e.102 TRUE 519.1 Tracheostomy complications Both 0 1 9 respiratory coral4 1, 0 PRS_PLINK_1.58489319246107e.102 TRUE 519.2 Respiratory complications Both 0 4 9 respiratory coral4 4, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 519.8 Other diseases of respiratory system, NEC Both 4 23 9 respiratory coral4 23, 4 6, 0 6, 0 5, 0 6, 4 0.277 0.66 0.675 0.171 1.32 0.197 10 -1.07 2.24 0.634 0.198 0.344 0.00181 25.5 PRS_PLINK_1.58489319246107e.102 TRUE 519.9 Symptoms involving respiratory system and other chest symptoms Both 6 43 9 respiratory coral4 43, 6 10, 1 11, 0 10, 1 11, 4 1.14 0.682 0.095 1.022 3.12 0.949 124 -0.108 1.32 0.935 0.029 0.897 0.0041 222 -0.597 1.63 0.714 0.146 0.55 9.7e-05 11.5 0.184 1.53 0.905 0.043 1.2 0.0379 3010 PRS_PLINK_1.58489319246107e.102 TRUE 520 Disorders of tooth development Both 0 8 10 digestive chartreuse4 8, 0 1 2 2 2 PRS_PLINK_1.58489319246107e.102 TRUE 520.1 Hereditary disturbances in tooth structure Both 0 5 10 digestive chartreuse4 5, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 520.2 Disturbances in tooth eruption Both 0 9 10 digestive chartreuse4 9, 0 3 2 2 2 PRS_PLINK_1.58489319246107e.102 TRUE 521 Diseases of hard tissues of teeth Both 0 13 10 digestive chartreuse4 13, 0 3 3 3 3 PRS_PLINK_1.58489319246107e.102 TRUE 521.1 Dental caries Both 0 12 10 digestive chartreuse4 12, 0 2 3 3 3 PRS_PLINK_1.58489319246107e.102 TRUE 522 Diseases of pulp and periapical tissues Both 1 7 10 digestive chartreuse4 7, 1 2, 1 2, 0 1, 0 2, 0 0.704 292 0.998 0.001 2.02 0.274 448 -0.0842 6560 1 0 0.919 0.0434 16.5 -1.86e-05 11 1 0 1 0.868 1.05 0.0115 257 1 0 1.01 0.857 1.46 PRS_PLINK_1.58489319246107e.102 TRUE 522.5 Periapical abscess Both 1 5 10 digestive chartreuse4 5, 1 2, 1 1, 0 1, 0 1, 0 0.0138 665 1 0 1.01 0.863 1.23 0.000995 9.7 1 0 1 0.978 1.07 0.123 3520 1 0 1.13 0.657 1.32 0.00391 53 1 0 1 0.873 1.08 PRS_PLINK_1.58489319246107e.102 TRUE 523 Gingival and periodontal diseases Both 0 10 10 digestive chartreuse4 10, 0 2 2 2 3 PRS_PLINK_1.58489319246107e.102 TRUE 523.1 Gingivitis Both 0 3 10 digestive chartreuse4 3, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 523.3 Periodontitis (acute or chronic) Both 0 4 10 digestive chartreuse4 4, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 523.31 Acute periodontitis Both 0 2 10 digestive chartreuse4 2, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 523.32 Chronic periodontitis Both 0 1 10 digestive chartreuse4 1, 0 PRS_PLINK_1.58489319246107e.102 TRUE 524 Dentofacial anomalies, including malocclusion Both 2 6 10 digestive chartreuse4 6, 2 2, 1 1, 1 1, 0 2, 0 -0.00279 17.4 1 0 0.997 0.852 1.1 0.469 6220 1 0 1.6 0.0124 1350 0.0629 1410 1 0 1.06 0.77 1.08 0.245 210 0.999 0 1.28 0.684 2.78 PRS_PLINK_1.58489319246107e.102 TRUE 524.3 Anomalies of tooth position/malocclusion Both 0 2 10 digestive chartreuse4 2, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 525 Other diseases of the teeth and supporting structures Both 1 17 10 digestive chartreuse4 17, 1 4, 1 4, 0 4, 0 4, 0 -0.384 0.661 0.561 0.251 0.681 0.16 2.83 0.34 27.8 0.99 0.004 1.4 0.0155 1.6 -0.786 12.9 0.951 0.022 0.456 0.0462 0.472 0.517 123 0.997 0.001 1.68 1.53 3.94 PRS_PLINK_1.58489319246107e.102 TRUE 525.1 Loss of teeth or edentulism Both 0 7 10 digestive chartreuse4 7, 0 2 2 1 2 PRS_PLINK_1.58489319246107e.102 TRUE 526 Diseases of the jaws Both 4 37 10 digestive chartreuse4 37, 4 9, 1 9, 1 9, 2 9, 0 -0.195 0.575 0.734 0.134 0.822 0.184 6 -0.327 1.72 0.849 0.071 0.721 0.00556 80.8 0.964 2.21 0.663 0.178 2.62 0.0504 6600 -0.539 2.47 0.828 0.082 0.583 0.000134 885 PRS_PLINK_1.58489319246107e.102 TRUE 526.1 Cysts of the jaws Both 1 6 10 digestive chartreuse4 6, 1 2, 1 1, 0 1, 0 2, 0 -0.0253 944 1 0 0.975 0.964 1.34 0.036 949 1 0 1.04 0.934 1.54 1.2 9500 1 0 3.33 0.291 3.52 -0.0344 744 1 0 0.966 0.663 1.16 PRS_PLINK_1.58489319246107e.102 TRUE 526.3 Anomalies of jaw size/symmetry Both 1 2 10 digestive chartreuse4 2, 1 1, 1 1, 0 1, 1 1, 0 -0.022 116 1 0 0.978 0.862 1.07 0.0196 102 1 0 1.02 0.717 1.12 PRS_PLINK_1.58489319246107e.102 TRUE 526.4 Temporomandibular joint disorders Both 2 20 10 digestive chartreuse4 20, 2 5, 0 5, 0 5, 2 5, 0 0.377 0.864 0.663 0.179 1.46 0.261 20.3 1.46 3.1 0.638 0.195 4.3 0.0572 1390 PRS_PLINK_1.58489319246107e.102 TRUE 526.41 Temporomandibular joint disorder, unspecified Both 2 17 10 digestive chartreuse4 17, 2 5, 0 4, 0 4, 2 4, 0 0.359 1.15 0.754 0.123 1.43 0.198 30.3 0.741 3.06 0.809 0.092 2.1 0.0233 300 PRS_PLINK_1.58489319246107e.102 TRUE 526.42 Arthralgia/ankylosis of temporomandibular joint Both 1 9 10 digestive chartreuse4 9, 1 3, 0 2, 0 2, 1 2, 0 4.01e-14 2.1 1 0 1 0.0424 47.6 0.302 6240 1 0 1.35 0.147 2.45 PRS_PLINK_1.58489319246107e.102 TRUE 526.5 Inflammatory conditions of jaw Both 0 3 10 digestive chartreuse4 3, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 526.9 Jaw disease NOS Both 0 8 10 digestive chartreuse4 8, 0 1 2 2 2 PRS_PLINK_1.58489319246107e.102 TRUE 527 Diseases of the salivary glands Both 3 18 10 digestive chartreuse4 18, 3 4, 1 4, 0 4, 1 5, 1 0.496 0.762 0.515 0.289 1.64 0.502 26.3 0.591 22300000 1 0 1.81 0.114 27100 2.47 4.1 0.548 0.262 11.8 0.049 9080 0.305 9.09 0.973 0.012 1.36 1.35e-06 53800000 PRS_PLINK_1.58489319246107e.102 TRUE 527.1 Hypertrophy of salivary gland Both 0 2 10 digestive chartreuse4 2, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 527.2 Sialoadenitis Both 1 5 10 digestive chartreuse4 5, 1 1, 0 1, 0 1, 0 1, 1 0.00535 285 1 0 1.01 0.839 1.38 0.127 1140 1 0 1.14 0.759 2.74 PRS_PLINK_1.58489319246107e.102 TRUE 527.7 Disturbance of salivary secretion Both 2 7 10 digestive chartreuse4 7, 2 2, 1 2, 0 1, 0 2, 1 -0.661 254 0.998 0.001 0.516 0.269 0.752 -0.0111 37.9 1 0 0.989 0.327 1.14 0.615 5690 1 0 1.85 0.0045 2.58 1.42 2890000 1 0 4.16 0.316 166 PRS_PLINK_1.58489319246107e.102 TRUE 527.8 Other specified diseases of the salivary glands Both 0 2 10 digestive chartreuse4 2, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 528 Diseases of the oral soft tissues, excluding lesions specific for gingiva and tongue Both 6 34 10 digestive chartreuse4 34, 6 8, 1 8, 3 8, 2 9, 0 0.49 0.611 0.423 0.374 1.63 0.533 9.41 0.585 1.79 0.743 0.129 1.8 0.009 95300000 0.98 1.5 0.513 0.29 2.67 0.19 50.5 -0.339 2.37 0.886 0.053 0.713 7.39e-06 74 PRS_PLINK_1.58489319246107e.102 TRUE 528.1 Stomatitis and mucositis Both 1 9 10 digestive chartreuse4 9, 1 3, 0 2, 1 2, 0 2, 0 0.0413 12.7 0.997 0.001 1.04 0.217 4.85 0.118 1960 1 0 1.13 0.526 3 PRS_PLINK_1.58489319246107e.102 TRUE 528.11 Stomatitis and mucositis (ulcerative) Both 0 2 10 digestive chartreuse4 2, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 528.12 Oral aphthae Both 1 3 10 digestive chartreuse4 3, 1 1, 0 1, 0 0, 1 1, 0 -2.72 8820 1 0 0.0657 5.51e-07 14400 -0.0034 55.6 1 0 0.997 0.951 1.1 PRS_PLINK_1.58489319246107e.102 TRUE 528.3 Cellulitis and abscess of oral soft tissues Both 0 7 10 digestive chartreuse4 7, 0 2 2 1 2 PRS_PLINK_1.58489319246107e.102 TRUE 528.4 Cysts of oral soft tissues Both 0 2 10 digestive chartreuse4 2, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 528.5 Diseases of lips Both 1 5 10 digestive chartreuse4 5, 1 1, 0 1, 0 1, 0 1, 1 5.51e-05 55.7 1 0 1 0.547 1.82 -0.0148 52.7 1 0 0.985 0.8 1.06 PRS_PLINK_1.58489319246107e.102 TRUE 528.6 Leukoplakia of oral mucosa Both 2 2 10 digestive chartreuse4 2, 2 1, 2 1, 0 1, 2 1, 0 -12.8 8.55e+09 1 0 2.73e-06 1.74e-41 6.33e+40 0.0132 23.6 1 0 1.01 0.823 1.34 PRS_PLINK_1.58489319246107e.102 TRUE 528.7 Sialolithiasis Both 0 1 10 digestive chartreuse4 1, 0 PRS_PLINK_1.58489319246107e.102 TRUE 529 Diseases and other conditions of the tongue Both 1 5 10 digestive chartreuse4 5, 1 2, 0 1, 0 1, 0 1, 1 0.167 3870 1 0 1.18 0.156 30.2 0.327 6570 1 0 1.39 0.475 1.89 PRS_PLINK_1.58489319246107e.102 TRUE 529.1 Glossitis Both 0 2 10 digestive chartreuse4 2, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 529.6 Glossodynia Both 0 2 10 digestive chartreuse4 2, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 530 Diseases of esophagus Both 26 36 10 digestive chartreuse4 36, 26 8, 8 9, 2 9, 6 9, 10 0.0439 0.29 0.88 0.056 1.04 0.616 1.8 -1.34 0.934 0.15 0.823 0.261 0.0352 1.19 -0.49 1.09 0.653 0.185 0.612 0.0731 4.78 0.175 0.856 0.838 0.077 1.19 0.259 5.61 PRS_PLINK_1.58489319246107e.102 TRUE 530.1 Esophagitis, GERD and related diseases Both 25 36 10 digestive chartreuse4 36, 25 8, 8 9, 2 9, 6 9, 9 -0.014 0.295 0.962 0.017 0.986 0.575 1.71 -1.34 0.934 0.15 0.823 0.261 0.0352 1.19 -0.49 1.09 0.653 0.185 0.612 0.0731 4.78 0.0836 0.867 0.923 0.035 1.09 0.234 5.17 PRS_PLINK_1.58489319246107e.102 TRUE 530.11 GERD Both 24 36 10 digestive chartreuse4 36, 24 8, 7 9, 2 9, 6 9, 9 0.0387 0.301 0.898 0.047 1.04 0.603 1.83 -1.17 0.947 0.216 0.665 0.31 0.0449 1.42 -0.198 1.14 0.862 0.064 0.821 0.0973 8.12 0.241 0.893 0.787 0.104 1.27 0.268 6.39 PRS_PLINK_1.58489319246107e.102 TRUE 530.13 Barrett's esophagus Both 0 10 10 digestive chartreuse4 10, 0 3 2 2 3 PRS_PLINK_1.58489319246107e.102 TRUE 530.14 Reflux esophagitis Both 6 21 10 digestive chartreuse4 21, 6 6, 3 5, 0 5, 1 5, 2 3.01 1.95 0.121 0.916 20.4 0.704 26.2 -1.37 2.01 0.495 0.305 0.253 0.000602 7.46 1.35 2.41 0.575 0.24 3.87 0.0799 49100 1.19 1.86 0.522 0.282 3.29 0.123 3600 PRS_PLINK_1.58489319246107e.102 TRUE 530.15 Eosinophilic esophagitis Both 1 5 10 digestive chartreuse4 5, 1 2, 0 1, 0 1, 0 1, 1 -0.0026 37.9 1 0 0.997 0.614 1.42 0.00511 327 1 0 1.01 0.941 1.08 PRS_PLINK_1.58489319246107e.102 TRUE 530.2 Esophageal bleeding (varices/hemorrhage) Both 0 6 10 digestive chartreuse4 6, 0 2 1 1 2 PRS_PLINK_1.58489319246107e.102 TRUE 530.3 Stricture and stenosis of esophagus Both 1 9 10 digestive chartreuse4 9, 1 3, 0 2, 0 2, 0 2, 1 0.674 2.18 0.757 0.121 1.96 1.85 2.06 -0.0101 1260 1 0 0.99 0.0107 1.24 PRS_PLINK_1.58489319246107e.102 TRUE 530.5 Disorders of esophageal motility Both 1 6 10 digestive chartreuse4 6, 1 2, 0 1, 0 1, 0 2, 1 0.387 166 0.998 0.001 1.47 0.458 4.6 0.428 2070 1 0 1.53 0.621 1.62 PRS_PLINK_1.58489319246107e.102 TRUE 530.6 Diverticulum of esophagus, acquired Both 0 2 10 digestive chartreuse4 2, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 530.7 Gastroesophageal laceration-hemorrhage syndrome Both 2 1 10 digestive chartreuse4 1, 2 -0.0627 376 1 0 0.939 0.777 1.16 PRS_PLINK_1.58489319246107e.102 TRUE 530.9 Heartburn Both 2 21 10 digestive chartreuse4 21, 2 6, 1 5, 0 5, 0 5, 1 -0.0793 0.619 0.898 0.047 0.924 0.281 35.9 -3.03 8.95 0.735 0.134 0.0485 0.0397 0.0597 -0.23 2.69 0.932 0.031 0.795 0.00746 56.7 -0.165 1.89 0.93 0.031 0.848 0.00205 20.1 PRS_PLINK_1.58489319246107e.102 TRUE 531 Peptic ulcer (excl. esophageal) Both 3 17 10 digestive chartreuse4 17, 3 5, 1 4, 0 4, 0 4, 2 -0.404 1.02 0.691 0.16 0.667 0.0808 8.66 0.000216 285 1 0 1 0.768 1.36 -2 10.5 0.849 0.071 0.135 0.00471 0.142 4.66 6.83 0.495 0.306 106 0.00931 3.16e+12 PRS_PLINK_1.58489319246107e.102 TRUE 531.1 Hemorrhage from gastrointestinal ulcer Both 1 1 10 digestive chartreuse4 1, 1 0.00792 101 1 0 1.01 0.878 1.18 PRS_PLINK_1.58489319246107e.102 TRUE 531.2 Gastric ulcer Both 3 10 10 digestive chartreuse4 10, 3 3, 1 2, 0 2, 0 3, 2 -0.379 3.63 0.917 0.038 0.685 0.00257 387 -0.284 4270 1 0 0.753 0.734 2.15 0.0154 461 1 0 1.02 0.69 2.06 0.987 53.9 0.985 0.006 2.68 43.9 254 PRS_PLINK_1.58489319246107e.102 TRUE 531.3 Duodenal ulcer Both 0 2 10 digestive chartreuse4 2, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 531.4 Peptic ulcer, site unspecified Both 1 7 10 digestive chartreuse4 7, 1 2, 1 2, 0 1, 0 2, 0 -0.847 145 0.995 0.002 0.429 0.219 0.623 -0.112 8460 1 0 0.894 0.593 1.45 -16.4 92400 1 0 7.51e-08 1.72e-27 1.16e+14 2.98 2.7e+08 1 0 19.8 2.47e-07 1.13e+10 PRS_PLINK_1.58489319246107e.102 TRUE 531.5 Gastrojejunal ulcer Both 0 1 10 digestive chartreuse4 1, 0 PRS_PLINK_1.58489319246107e.102 TRUE 532 Dysphagia Both 7 34 10 digestive chartreuse4 34, 7 8, 2 8, 0 8, 1 9, 4 0.531 0.47 0.258 0.589 1.7 0.737 5.33 -1.12 1.37 0.415 0.382 0.326 0.000543 3.24 -0.551 1.29 0.668 0.175 0.576 0.0191 4.97 0.963 1.24 0.437 0.359 2.62 0.357 75.4 PRS_PLINK_1.58489319246107e.102 TRUE 535 Gastritis and duodenitis Both 10 31 10 digestive chartreuse4 31, 10 7, 1 8, 1 7, 4 8, 4 0.951 0.611 0.119 0.923 2.59 0.942 12.2 -0.478 2.14 0.823 0.085 0.62 0.00475 73.9 1.74 1.57 0.269 0.571 5.67 0.476 595 0.715 1.61 0.656 0.183 2.04 0.177 3230 PRS_PLINK_1.58489319246107e.102 TRUE 535.1 Acute gastritis Both 2 11 10 digestive chartreuse4 11, 2 3, 0 3, 0 2, 0 3, 2 -0.779 2.25 0.729 0.137 0.459 0.428 0.497 -0.532 1140 1 0 0.587 0.133 0.542 PRS_PLINK_1.58489319246107e.102 TRUE 535.2 Atrophic gastritis Both 3 1 10 digestive chartreuse4 1, 3 -12.1 52300 1 0 5.59e-06 4.05e-20 3400000 PRS_PLINK_1.58489319246107e.102 TRUE 535.6 Duodenitis Both 1 3 10 digestive chartreuse4 3, 1 1, 1 1, 0 1, 0 1, 1 1.41 10900 1 0 4.08 0.0239 12.4 0.0679 72.2 0.999 0 1.07 0.676 2.31 -0.0217 90.8 1 0 0.979 0.787 1.24 PRS_PLINK_1.58489319246107e.102 TRUE 535.8 Other specified gastritis Both 2 7 10 digestive chartreuse4 7, 2 2, 2 2, 0 1, 0 2, 0 -0.802 2.76 0.771 0.113 0.449 0.00695 28 -0.00858 86.5 1 0 0.991 0.727 1.43 -0.00585 889 1 0 0.994 0.714 1.13 -0.61 1140 1 0 0.544 0.0959 2.12 PRS_PLINK_1.58489319246107e.102 TRUE 535.9 Gastritis and duodenitis, NOS Both 2 15 10 digestive chartreuse4 15, 2 3, 0 4, 1 3, 0 4, 1 0.776 1.46 0.595 0.226 2.17 0.196 373 -0.534 214 0.998 0.001 0.586 0.0393 3.85 -0.173 3900 1 0 0.841 0.782 1.8 PRS_PLINK_1.58489319246107e.102 TRUE 536 Disorders of function of stomach Both 15 30 10 digestive chartreuse4 30, 15 7, 2 7, 2 7, 5 8, 6 0.388 0.412 0.347 0.46 1.47 0.724 3.59 -0.732 1.54 0.635 0.197 0.481 0.00444 34 0.455 1.5 0.762 0.118 1.58 0.0641 41.9 -0.283 1.39 0.839 0.076 0.754 0.0463 10 PRS_PLINK_1.58489319246107e.102 TRUE 536.3 Gastroparesis Both 6 16 10 digestive chartreuse4 16, 6 4, 0 4, 4 4, 1 4, 1 0.571 0.89 0.521 0.283 1.77 0.409 10.5 2.69 3.7 0.467 0.331 14.8 0.136 18.3 1.27 129 0.992 0.003 3.55 4.81 5.95 1.26 18.7 0.946 0.024 3.53 0.419 4.26 PRS_PLINK_1.58489319246107e.102 TRUE 536.7 Complications of gastrostomy, colostomy and enterostomy Both 2 2 10 digestive chartreuse4 2, 2 1, 1 1, 1 1, 1 1, 1 0.0054 847 1 0 1.01 0.649 1.34 -0.127 14300000 1 0 0.88 0.481 1.08 PRS_PLINK_1.58489319246107e.102 TRUE 536.8 Dyspepsia and other specified disorders of function of stomach Both 9 25 10 digestive chartreuse4 25, 9 7, 2 6, 0 6, 3 6, 4 0.196 0.542 0.718 0.144 1.22 0.446 3.64 -0.339 1.56 0.829 0.082 0.713 0.00853 95.9 -0.285 1.84 0.877 0.057 0.752 0.0186 34 0.0727 1.37 0.958 0.019 1.08 0.106 10.8 PRS_PLINK_1.58489319246107e.102 TRUE 537 Other disorders of stomach and duodenum Both 12 33 10 digestive chartreuse4 33, 12 8, 3 8, 2 8, 3 8, 4 0.117 0.393 0.765 0.116 1.12 0.572 2.45 -0.0872 1.23 0.944 0.025 0.916 0.00874 30.3 3.03 2.61 0.245 0.61 20.7 0.166 28.1 -0.764 1.68 0.649 0.188 0.466 0.0017 32.6 PRS_PLINK_1.58489319246107e.102 TRUE 537.1 Lesions of stomach and duodenum Both 0 1 10 digestive chartreuse4 1, 0 PRS_PLINK_1.58489319246107e.102 TRUE 539 Bariatric surgery Both 1 27 10 digestive chartreuse4 27, 1 6, 0 7, 0 6, 0 7, 1 -0.0319 0.653 0.961 0.017 0.969 0.225 15.4 1.32 2.76 0.632 0.199 3.75 0.0669 338 PRS_PLINK_1.58489319246107e.102 TRUE 540 Appendiceal conditions Both 0 6 10 digestive chartreuse4 6, 0 2 1 1 2 PRS_PLINK_1.58489319246107e.102 TRUE 540.1 Appendicitis Both 0 3 10 digestive chartreuse4 3, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 540.11 Acute appendicitis Both 0 3 10 digestive chartreuse4 3, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 550 Abdominal hernia Both 9 49 10 digestive chartreuse4 49, 9 12, 3 12, 2 12, 2 12, 2 0.253 0.407 0.534 0.272 1.29 0.59 3.27 0.443 1.1 0.688 0.163 1.56 0.119 24.5 -0.556 1.3 0.669 0.174 0.573 0.00479 7.76 0.367 1.17 0.753 0.123 1.44 0.15 19 PRS_PLINK_1.58489319246107e.102 TRUE 550.1 Inguinal hernia Both 3 20 10 digestive chartreuse4 20, 3 5, 0 5, 1 5, 1 5, 1 0.332 0.731 0.65 0.187 1.39 0.382 10.8 -1.24e-11 22.1 1 0 1 1.03e-06 845000 -2.95e-14 3.47 1 0 1 0.00239 254 -0.204 6.4 0.975 0.011 0.815 2.48e-07 2e+06 PRS_PLINK_1.58489319246107e.102 TRUE 550.2 Diaphragmatic hernia Both 5 28 10 digestive chartreuse4 28, 5 6, 2 7, 1 7, 1 7, 1 0.265 0.58 0.648 0.188 1.3 0.476 7.24 0.677 1.41 0.631 0.2 1.97 0.217 59.9 0.0456 2.87 0.987 0.006 1.05 2.03e-05 14700 0.466 1.64 0.777 0.11 1.59 0.0977 81.5 PRS_PLINK_1.58489319246107e.102 TRUE 550.3 Femoral hernia Both 0 2 10 digestive chartreuse4 2, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 550.4 Umbilical hernia Both 1 13 10 digestive chartreuse4 13, 1 4, 0 3, 0 3, 0 3, 1 0.092 0.96 0.924 0.035 1.1 0.264 21 -0.00604 129 1 0 0.994 0.431 1.09 PRS_PLINK_1.58489319246107e.102 TRUE 550.5 Ventral hernia Both 3 22 10 digestive chartreuse4 22, 3 5, 1 5, 1 5, 0 6, 1 0.403 0.723 0.578 0.238 1.5 0.413 30.1 -1.76 2.58 0.495 0.306 0.172 0.000751 5.8 0.973 4.5 0.829 0.082 2.65 0.00517 6030 1.26 5.56 0.82 0.086 3.54 0.000581 389000 PRS_PLINK_1.58489319246107e.102 TRUE 550.6 Incisional hernia Both 0 13 10 digestive chartreuse4 13, 0 3 3 3 3 PRS_PLINK_1.58489319246107e.102 TRUE 555 Inflammatory bowel disease and other gastroenteritis and colitis Both 5 11 10 digestive chartreuse4 11, 5 2, 1 3, 0 2, 4 3, 0 -1.15 1.47 0.433 0.364 0.317 0.278 2.92 -0.0783 1620 1 0 0.925 3.56e-11 8.74e+17 -0.209 34800000 1 0 0.812 0.00132 2570 3.88 2790 0.999 0 48.4 7.12e-09 3770000 PRS_PLINK_1.58489319246107e.102 TRUE 555.1 Regional enteritis Both 1 9 10 digestive chartreuse4 9, 1 3, 0 2, 1 2, 0 2, 0 0.0534 2.24 0.981 0.008 1.05 0.0349 24.4 -0.117 2110 1 0 0.889 0.354 1.62 PRS_PLINK_1.58489319246107e.102 TRUE 555.2 Ulcerative colitis Both 4 6 10 digestive chartreuse4 6, 4 2, 0 1, 4 1, 0 2, 0 -0.44 21 0.983 0.007 0.644 0.566 2450 0.0368 1010 1 0 1.04 0.46 6.5 PRS_PLINK_1.58489319246107e.102 TRUE 555.21 Ulcerative colitis (chronic) Both 4 5 10 digestive chartreuse4 5, 4 2, 4 1, 0 1, 0 1, 0 0.0706 178 1 0 1.07 0.864 1.47 -24.2 46300000 1 0 2.98e-11 7.22e-46 4.54e-09 -7.47 1040 0.994 0.003 0.00057 6.6e-15 1.07e+10 -11 1040 0.992 0.004 1.72e-05 2.48e-19 2.35e+13 PRS_PLINK_1.58489319246107e.102 TRUE 556 Ulceration of the lower GI tract Both 0 7 10 digestive chartreuse4 7, 0 2 2 1 2 PRS_PLINK_1.58489319246107e.102 TRUE 556.1 Ulceration of intestine Both 0 5 10 digestive chartreuse4 5, 0 2 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 556.11 Angiodysplasia of intestine (without mention of hemorrhage) Both 0 2 10 digestive chartreuse4 2, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 557 Intestinal malabsorption (non-celiac) Both 7 19 10 digestive chartreuse4 19, 7 4, 3 5, 1 4, 2 5, 1 -0.0442 0.523 0.933 0.03 0.957 0.372 2.4 -1.1 1.93 0.569 0.245 0.332 2.73e-05 7.72 -0.823 2.62 0.754 0.123 0.439 0.00224 24.7 -1.08 1.92 0.574 0.241 0.34 0.00115 4.99 PRS_PLINK_1.58489319246107e.102 TRUE 557.1 Celiac disease Both 4 8 10 digestive chartreuse4 8, 4 1, 1 2, 2 2, 1 2, 0 -0.713 1.52 0.639 0.194 0.49 0.0131 4.83 0 3210 1 0 1 0.00983 15.7 -0.413 3680 1 0 0.662 0.0106 2.87 -0.302 3020 1 0 0.74 0.588 1.39 PRS_PLINK_1.58489319246107e.102 TRUE 558 Noninfectious gastroenteritis Both 11 23 10 digestive chartreuse4 23, 11 5, 2 6, 1 5, 7 6, 1 0.138 0.458 0.764 0.117 1.15 0.507 2.63 -2.01 2.93 0.493 0.307 0.134 9.92e-08 10.6 1.19 2.86 0.678 0.169 3.28 0.0381 491 0.668 2.38 0.779 0.109 1.95 0.0272 8490 PRS_PLINK_1.58489319246107e.102 TRUE 559 Ileostomy status Both 0 7 10 digestive chartreuse4 7, 0 2 2 1 2 PRS_PLINK_1.58489319246107e.102 TRUE 560 Intestinal obstruction without mention of hernia Both 5 20 10 digestive chartreuse4 20, 5 4, 0 5, 1 5, 2 5, 2 0.677 0.702 0.335 0.475 1.97 0.626 16.5 0.437 4.42 0.921 0.036 1.55 0.885 2.25 1.92 4.2 0.648 0.188 6.81 6.22 7.52 1.42 4.64 0.76 0.119 4.13 0.00531 261000 PRS_PLINK_1.58489319246107e.102 TRUE 560.1 Paralytic ileus Both 3 9 10 digestive chartreuse4 9, 3 3, 1 2, 0 2, 1 2, 1 0.358 1.07 0.738 0.132 1.43 0.315 14.1 4.88 4210 0.999 0 131 1.51e-07 5.4e+11 0.000213 115 1 0 1 0.176 6.76 0.0986 488 1 0 1.1 0.751 1.13 PRS_PLINK_1.58489319246107e.102 TRUE 560.2 Impaction of intestine Both 2 1 10 digestive chartreuse4 1, 2 -0.0432 1180 1 0 0.958 0.163 2.23 PRS_PLINK_1.58489319246107e.102 TRUE 560.3 Peritoneal or intestinal adhesions Both 0 1 10 digestive chartreuse4 1, 0 PRS_PLINK_1.58489319246107e.102 TRUE 560.4 Other intestinal obstruction Both 2 13 10 digestive chartreuse4 13, 2 3, 0 3, 0 3, 1 3, 1 0.485 1.37 0.723 0.141 1.62 0.0159 58.2 0.323 897 1 0 1.38 0.406 15.2 -0.452 3450 1 0 0.636 0.000541 6180 PRS_PLINK_1.58489319246107e.102 TRUE 561 Symptoms involving digestive system Both 7 21 10 digestive chartreuse4 21, 7 5, 1 5, 1 5, 3 5, 2 0.131 0.492 0.791 0.102 1.14 0.483 2.76 0.261 3.14 0.934 0.03 1.3 0.0128 339 -0.124 1.95 0.949 0.023 0.884 0.00707 230 0.296 1.97 0.881 0.055 1.34 0.000743 56.8 PRS_PLINK_1.58489319246107e.102 TRUE 562 Diverticulosis and diverticulitis Both 6 21 10 digestive chartreuse4 21, 6 5, 0 5, 2 5, 3 5, 1 0.295 0.671 0.661 0.18 1.34 0.285 9.37 0.574 3.08 0.852 0.07 1.78 0.0164 270 1.82 5.34 0.734 0.135 6.16 0.000737 91700 -8.24e-13 10.4 1 0 1 1.14e-07 20300000 PRS_PLINK_1.58489319246107e.102 TRUE 562.1 Diverticulosis Both 6 21 10 digestive chartreuse4 21, 6 5, 0 5, 2 5, 3 5, 1 0.295 0.671 0.661 0.18 1.34 0.285 9.37 0.574 3.08 0.852 0.07 1.78 0.0164 270 1.82 5.34 0.734 0.135 6.16 0.000737 91700 -8.24e-13 10.4 1 0 1 1.14e-07 20300000 PRS_PLINK_1.58489319246107e.102 TRUE 562.2 Diverticulitis Both 1 14 10 digestive chartreuse4 14, 1 4, 1 3, 0 3, 0 4, 0 0.136 0.925 0.883 0.054 1.15 0.215 7.52 -0.725 1370 1 0 0.484 0.186 3.29 0.0173 232 1 0 1.02 0.854 1.3 -1.93 2840 0.999 0 0.145 5.89e-05 0.095 PRS_PLINK_1.58489319246107e.102 TRUE 564 Functional digestive disorders Both 27 27 10 digestive chartreuse4 27, 27 6, 4 7, 6 6, 10 7, 7 0.367 0.33 0.266 0.575 1.44 0.812 2.72 0.15 1.13 0.894 0.048 1.16 0.143 9.44 3.14 2.09 0.133 0.875 23.1 0.744 6.48e+08 0.297 1.47 0.839 0.076 1.35 0.109 23.8 PRS_PLINK_1.58489319246107e.102 TRUE 564.1 Irritable Bowel Syndrome Both 5 23 10 digestive chartreuse4 23, 5 5, 0 6, 0 5, 3 6, 2 0.468 0.548 0.393 0.405 1.6 0.623 6.53 1.81 2.44 0.459 0.339 6.12 0.155 1630 -0.00892 2.29 0.997 0.001 0.991 0.00217 126 PRS_PLINK_1.58489319246107e.102 TRUE 564.9 Personal history of diseases of digestive system Both 5 20 10 digestive chartreuse4 20, 5 4, 0 5, 1 5, 3 5, 1 0.566 0.623 0.364 0.439 1.76 0.66 9.2 0.309 5.08 0.951 0.022 1.36 0.000363 2160 0.929 2.31 0.687 0.163 2.53 0.0313 5920 -3.28 15.6 0.834 0.079 0.0377 1.56e-10 2100000 PRS_PLINK_1.58489319246107e.102 TRUE 565 Anal and rectal conditions Both 11 31 10 digestive chartreuse4 31, 11 7, 0 8, 2 7, 4 8, 5 0.953 0.544 0.0801 1.097 2.59 1.06 11.3 0.406 1.62 0.802 0.096 1.5 0.00741 86.5 1 1.34 0.454 0.343 2.73 0.285 23300 1.39 1.34 0.3 0.523 4.02 0.515 936 PRS_PLINK_1.58489319246107e.102 TRUE 565.1 Anal and rectal polyp Both 3 9 10 digestive chartreuse4 9, 3 3, 0 2, 0 2, 0 2, 3 1.18 1.48 0.426 0.37 3.25 0.48 420 -0.0302 5360000 1 0 0.97 0.225 3.44 PRS_PLINK_1.58489319246107e.102 TRUE 567 Peritonitis and retroperitoneal infections Both 1 7 10 digestive chartreuse4 7, 1 2, 0 2, 0 1, 0 2, 1 0.505 810 1 0 1.66 0.419 10.4 -0.765 3400 1 0 0.466 0.0167 9.4 PRS_PLINK_1.58489319246107e.102 TRUE 568 Other disorders of peritoneum Both 1 12 10 digestive chartreuse4 12, 1 2, 0 3, 0 3, 1 3, 0 -0.325 1.63 0.842 0.074 0.723 0.00904 12.2 0.0612 1260 1 0 1.06 0.762 2.12 PRS_PLINK_1.58489319246107e.102 TRUE 568.1 Peritoneal adhesions (postoperative) (postinfection) Both 1 9 10 digestive chartreuse4 9, 1 2, 0 2, 0 2, 0 2, 1 1.5 7.53 0.842 0.074 4.47 3.69 5.22 -0.273 1350 1 0 0.761 0.115 1.23 PRS_PLINK_1.58489319246107e.102 TRUE 569 Other disorders of intestine Both 18 39 10 digestive chartreuse4 39, 18 9, 0 10, 2 9, 7 10, 9 0.647 0.378 0.087 1.061 1.91 0.987 4.28 0.38 1.45 0.793 0.101 1.46 0.0137 123 2.33 1.52 0.126 0.901 10.3 0.947 1580 2.28 1.46 0.117 0.931 9.78 0.997 6040 PRS_PLINK_1.58489319246107e.102 TRUE 569.1 Toxic gastroenteritis and colitis Both 0 3 10 digestive chartreuse4 3, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 569.2 Gastrointestinal complications Both 2 17 10 digestive chartreuse4 17, 2 4, 0 4, 0 4, 0 4, 2 0.382 1.12 0.732 0.135 1.47 0.0127 145 0.976 62.5 0.988 0.005 2.65 2.12 80.3 PRS_PLINK_1.58489319246107e.102 TRUE 571 Chronic liver disease and cirrhosis Both 9 33 10 digestive chartreuse4 33, 9 8, 2 8, 2 8, 1 8, 4 0.0607 0.403 0.88 0.055 1.06 0.516 2.33 -0.284 1.31 0.828 0.082 0.753 0.0425 7.65 -5.05 3.56 0.156 0.807 0.00638 8.81e-09 2.53 -0.0566 1.41 0.968 0.014 0.945 0.0147 62 PRS_PLINK_1.58489319246107e.102 TRUE 571.5 Other chronic nonalcoholic liver disease Both 9 34 10 digestive chartreuse4 34, 9 8, 2 8, 2 8, 1 9, 4 0.023 0.401 0.954 0.02 1.02 0.495 2.23 -0.284 1.31 0.828 0.082 0.753 0.0425 7.65 -5.05 3.56 0.156 0.807 0.00638 8.81e-09 2.53 -0.552 1.47 0.708 0.15 0.576 0.00461 16.1 PRS_PLINK_1.58489319246107e.102 TRUE 571.51 Cirrhosis of liver without mention of alcohol Both 0 14 10 digestive chartreuse4 14, 0 4 3 3 4 PRS_PLINK_1.58489319246107e.102 TRUE 571.6 Primary biliary cirrhosis Both 0 2 10 digestive chartreuse4 2, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 571.8 Liver abscess and sequelae of chronic liver disease Both 1 12 10 digestive chartreuse4 12, 1 3, 0 3, 0 3, 0 3, 1 1.11 4.71 0.813 0.09 3.04 5.77e-05 20500 0.942 27500000 1 0 2.57 0.00226 8270 PRS_PLINK_1.58489319246107e.102 TRUE 571.81 Portal hypertension Both 1 8 10 digestive chartreuse4 8, 1 2, 0 2, 0 2, 0 2, 1 -1.6e-12 9.92 1 0 1 0.981 3.35 -0.407 1480 1 0 0.666 0.134 1.36 PRS_PLINK_1.58489319246107e.102 TRUE 572 Ascites (non malignant) Both 1 23 10 digestive chartreuse4 23, 1 6, 0 6, 0 5, 0 6, 1 0.253 0.835 0.762 0.118 1.29 0.291 52 -1.24 3.43 0.716 0.145 0.288 0.259 1030 PRS_PLINK_1.58489319246107e.102 TRUE 573 Other disorders of liver Both 7 38 10 digestive chartreuse4 38, 7 9, 2 9, 2 9, 0 10, 3 -0.108 0.39 0.782 0.107 0.898 0.428 1.89 -0.221 1.25 0.859 0.066 0.802 0.057 7.61 -1.66 1.67 0.322 0.492 0.191 2.38e-06 3.13 -3.27 2.48 0.188 0.725 0.0381 1.01e-07 3.11 PRS_PLINK_1.58489319246107e.102 TRUE 573.1 Chronic passive congestion of liver Both 0 2 10 digestive chartreuse4 2, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 573.2 Liver replaced by transplant Both 0 6 10 digestive chartreuse4 6, 0 2 1 1 2 PRS_PLINK_1.58489319246107e.102 TRUE 573.3 Hepatomegaly Both 1 5 10 digestive chartreuse4 5, 1 2, 0 1, 0 1, 0 1, 1 -0.13 1210 1 0 0.878 0.35 1.34 -0.462 6240 1 0 0.63 0.131 2.72 PRS_PLINK_1.58489319246107e.102 TRUE 573.4 Acute and subacute necrosis of liver Both 0 3 10 digestive chartreuse4 3, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 573.5 Jaundice (not of newborn) Both 2 13 10 digestive chartreuse4 13, 2 4, 0 3, 1 3, 0 3, 1 -0.479 1.18 0.684 0.165 0.619 0.0547 5.78 0.000686 12.7 1 0 1 0.975 1.03 0.214 1940 1 0 1.24 0.0894 3.15 PRS_PLINK_1.58489319246107e.102 TRUE 573.6 Nonspecific elevation of levels of transaminase or lactic acid dehydrogenase [LDH] Both 7 31 10 digestive chartreuse4 31, 7 7, 0 8, 2 7, 2 8, 3 0.281 0.513 0.583 0.234 1.33 0.535 5.06 1.27 1.7 0.455 0.342 3.56 0.216 53600 -0.376 2.25 0.867 0.062 0.686 0.00277 153 0.27 1.8 0.881 0.055 1.31 0.00304 43500000 PRS_PLINK_1.58489319246107e.102 TRUE 573.7 Abnormal results of function study of liver Both 7 30 10 digestive chartreuse4 30, 7 7, 0 7, 5 7, 1 8, 1 0.0495 0.479 0.918 0.037 1.05 0.436 2.75 1.25 1.57 0.424 0.373 3.5 0.24 1550 0.494 1.93 0.798 0.098 1.64 0.00197 109000 0.0628 1.65 0.97 0.013 1.06 0.0399 46 PRS_PLINK_1.58489319246107e.102 TRUE 573.9 Abnormal serum enzyme levels Both 13 39 10 digestive chartreuse4 39, 13 9, 1 10, 4 9, 2 10, 6 0.654 0.428 0.126 0.9 1.92 0.921 4.97 1.89 1.41 0.18 0.745 6.63 0.689 390 0.801 1.46 0.584 0.233 2.23 0.153 2790000 1.48 1.32 0.264 0.579 4.38 0.479 92 PRS_PLINK_1.58489319246107e.102 TRUE 574 Cholelithiasis and cholecystitis Both 1 45 10 digestive chartreuse4 45, 1 11, 1 11, 0 11, 0 11, 0 -0.744 0.604 0.218 0.662 0.475 0.0222 1.73 -0.804 1.27 0.528 0.277 0.447 0.00796 4.49 -0.987 1.46 0.498 0.303 0.373 0.00139 5.13 -1.11 1.82 0.54 0.267 0.329 8.14e-08 194 PRS_PLINK_1.58489319246107e.102 TRUE 574.1 Cholelithiasis Both 1 43 10 digestive chartreuse4 43, 1 10, 1 11, 0 10, 0 11, 0 -0.574 0.549 0.296 0.529 0.563 0.0201 1.78 -0.937 1.35 0.488 0.311 0.392 0.0094 4.15 -0.865 1.45 0.551 0.259 0.421 0.0012 5.22 0.204 3.03 0.946 0.024 1.23 3.47e-05 2050 PRS_PLINK_1.58489319246107e.102 TRUE 574.11 Cholelithiasis with acute cholecystitis Both 0 6 10 digestive chartreuse4 6, 0 2 1 1 2 PRS_PLINK_1.58489319246107e.102 TRUE 574.12 Cholelithiasis with other cholecystitis Both 0 14 10 digestive chartreuse4 14, 0 4 3 3 4 PRS_PLINK_1.58489319246107e.102 TRUE 574.2 Calculus of bile duct Both 0 11 10 digestive chartreuse4 11, 0 3 3 2 3 PRS_PLINK_1.58489319246107e.102 TRUE 574.3 Cholecystitis without cholelithiasis Both 0 14 10 digestive chartreuse4 14, 0 4 3 3 4 PRS_PLINK_1.58489319246107e.102 TRUE 575 Other biliary tract disease Both 0 33 10 digestive chartreuse4 33, 0 8 8 8 8 PRS_PLINK_1.58489319246107e.102 TRUE 575.1 Cholangitis Both 0 1 10 digestive chartreuse4 1, 0 PRS_PLINK_1.58489319246107e.102 TRUE 575.2 Obstruction of bile duct Both 0 5 10 digestive chartreuse4 5, 0 2 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 575.6 Cholesterolosis of gallbladder Both 0 5 10 digestive chartreuse4 5, 0 2 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 575.7 Other disorders of gallbladder Both 0 12 10 digestive chartreuse4 12, 0 2 3 3 3 PRS_PLINK_1.58489319246107e.102 TRUE 575.8 Other disorders of biliary tract Both 0 12 10 digestive chartreuse4 12, 0 3 3 3 3 PRS_PLINK_1.58489319246107e.102 TRUE 577 Diseases of pancreas Both 3 31 10 digestive chartreuse4 31, 3 8, 0 8, 0 7, 2 8, 1 0.172 0.943 0.855 0.068 1.19 0.00934 408 -0.203 1.84 0.912 0.04 0.816 0.00513 111 0.631 2.7 0.815 0.089 1.88 0.0391 18400 PRS_PLINK_1.58489319246107e.102 TRUE 577.1 Acute pancreatitis Both 1 19 10 digestive chartreuse4 19, 1 5, 0 5, 1 4, 0 5, 0 0.371 0.942 0.694 0.159 1.45 0.296 351 0.521 1.67 0.756 0.122 1.68 0.0599 52 PRS_PLINK_1.58489319246107e.102 TRUE 577.2 Chronic pancreatitis Both 0 3 10 digestive chartreuse4 3, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 577.3 Cyst and pseudocyst of pancreas Both 0 4 10 digestive chartreuse4 4, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 578 Gastrointestinal hemorrhage Both 13 46 10 digestive chartreuse4 46, 13 11, 1 11, 3 11, 6 12, 3 0.316 0.357 0.376 0.425 1.37 0.717 2.92 0.707 1.23 0.565 0.248 2.03 0.198 109 1.04 1.07 0.331 0.48 2.82 0.452 43.7 1 1.34 0.456 0.341 2.72 0.269 124 PRS_PLINK_1.58489319246107e.102 TRUE 578.1 Hematemesis Both 4 5 10 digestive chartreuse4 5, 4 2, 0 1, 0 1, 1 1, 3 -0.015 22.4 0.999 0 0.985 0.749 1.1 -0.0402 3890 1 0 0.961 0.142 6.19 0.0953 394 1 0 1.1 0.872 1.13 PRS_PLINK_1.58489319246107e.102 TRUE 578.2 Blood in stool Both 7 33 10 digestive chartreuse4 33, 7 8, 0 8, 2 8, 2 8, 3 0.597 0.486 0.219 0.659 1.82 0.77 5.68 0.631 1.62 0.698 0.156 1.88 0.0192 229 0.677 1.53 0.659 0.181 1.97 0.00607 175 0.989 1.37 0.47 0.328 2.69 0.311 1700 PRS_PLINK_1.58489319246107e.102 TRUE 578.8 Hemorrhage of rectum and anus Both 7 31 10 digestive chartreuse4 31, 7 7, 1 8, 0 7, 4 8, 2 0.569 0.565 0.314 0.503 1.77 0.63 8.86 -0.134 1.35 0.921 0.036 0.875 0.0398 26.8 1.35 1.56 0.386 0.413 3.87 0.297 965 1.44 2.12 0.498 0.303 4.21 0.058 2270000 PRS_PLINK_1.58489319246107e.102 TRUE 578.9 Hemorrhage of gastrointestinal tract Both 3 16 10 digestive chartreuse4 16, 3 4, 0 4, 2 4, 1 4, 0 0.204 0.774 0.792 0.101 1.23 0.211 48.2 -0.0204 148 1 0 0.98 0.664 1.2 0.349 72.5 0.996 0.002 1.42 0.259 0.755 PRS_PLINK_1.58489319246107e.102 TRUE 579 Other symptoms involving abdomen and pelvis Both 6 41 10 digestive chartreuse4 41, 6 10, 0 10, 1 10, 3 10, 2 0.51 0.42 0.225 0.648 1.67 0.771 4.77 -0.449 1.86 0.809 0.092 0.638 0.0022 79.9 1.58 1.27 0.212 0.673 4.88 0.576 109 2.14 2.13 0.314 0.502 8.48 0.186 5.07e+08 PRS_PLINK_1.58489319246107e.102 TRUE 579.2 Splenomegaly Both 1 9 10 digestive chartreuse4 9, 1 3, 0 2, 0 2, 0 2, 1 -0.0276 3.2 0.993 0.003 0.973 0.0071 122 -0.216 2200 1 0 0.806 0.555 1.45 PRS_PLINK_1.58489319246107e.102 TRUE 579.8 Nonspecific abnormal findings in stool contents Both 2 19 10 digestive chartreuse4 19, 2 5, 0 5, 0 4, 2 5, 0 0.00146 0.782 0.999 0.001 1 0.0805 11.4 0.292 2.17 0.893 0.049 1.34 0.0147 37.3 PRS_PLINK_1.58489319246107e.102 TRUE 580 Nephritis; nephrosis; renal sclerosis Both 15 11 11 genitourinary black 11, 15 3, 1 3, 5 2, 1 3, 8 0.861 0.818 0.293 0.533 2.36 0.603 14.6 2.46 2.17 0.256 0.592 11.7 0.583 1440 -0.0021 867 1 0 0.998 0.132 2.76 1.17 1.92 0.541 0.267 3.24 0.204 416 PRS_PLINK_1.58489319246107e.102 TRUE 580.1 Glomerulonephritis Both 2 4 11 genitourinary black 4, 2 1, 0 1, 0 1, 1 1, 1 -0.0334 2190 1 0 0.967 0.791 3.23 -0.00976 25.4 1 0 0.99 0.93 1.05 0.0258 110 1 0 1.03 0.685 1.48 PRS_PLINK_1.58489319246107e.102 TRUE 580.11 Proliferative glomerulonephritis Both 1 1 11 genitourinary black 1, 1 0.0016 160 1 0 1 0.946 1.03 PRS_PLINK_1.58489319246107e.102 TRUE 580.12 Non-proliferative glomerulonephritis Both 0 1 11 genitourinary black 1, 0 PRS_PLINK_1.58489319246107e.102 TRUE 580.13 Acute glomerulonephritis, NOS Both 1 1 11 genitourinary black 1, 1 23.6 127000 1 0 1.76e+10 1.85e+13 1.65e+52 PRS_PLINK_1.58489319246107e.102 TRUE 580.14 Chronic glomerulonephritis, NOS Both 0 2 11 genitourinary black 2, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 580.2 Nephrotic syndrome without mention of glomerulonephritis Both 0 3 11 genitourinary black 3, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 580.3 Nephritis and nephropathy without mention of glomerulonephritis Both 13 11 11 genitourinary black 11, 13 3, 1 3, 5 2, 1 3, 6 1.14 0.996 0.254 0.594 3.11 0.682 8980 2.46 2.17 0.256 0.592 11.7 0.583 1440 -0.0021 867 1 0 0.998 0.132 2.76 1.1 1.92 0.569 0.245 2.99 0.194 703 PRS_PLINK_1.58489319246107e.102 TRUE 580.31 Nephritis and nephropathy in diseases classified elsewhere Both 11 9 11 genitourinary black 9, 11 3, 1 2, 4 2, 1 2, 5 1.34 1.22 0.272 0.566 3.83 0.625 4.32 -0.482 46.2 0.992 0.004 0.618 0.597 0.64 -0.0021 867 1 0 0.998 0.132 2.76 -0.101 2.4 0.966 0.015 0.904 0.881 0.967 PRS_PLINK_1.58489319246107e.102 TRUE 580.32 Nephritis and nephropathy with pathological lesion Both 3 7 11 genitourinary black 7, 3 2, 1 2, 1 1, 0 2, 1 0.649 8.13 0.936 0.029 1.91 1.77 2.04 -0.0327 2510 1 0 0.968 0.839 2.68 0.12 1880 1 0 1.13 0.918 2.05 0.112 1640 1 0 1.12 0.421 3.83 PRS_PLINK_1.58489319246107e.102 TRUE 580.4 Renal sclerosis, NOS Both 1 3 11 genitourinary black 3, 1 1, 0 1, 0 1, 1 1, 0 -0.178 2700 1 0 0.837 0.779 1.7 -5.33 6.96e+08 1 0 0.00484 4.16e-16 6.26e+09 PRS_PLINK_1.58489319246107e.102 TRUE 585 Renal failure Both 24 16 11 genitourinary black 16, 24 4, 5 4, 6 4, 6 4, 6 0.275 0.527 0.601 0.221 1.32 0.496 3.83 0.958 1.59 0.547 0.262 2.61 0.212 5270 1.38 1.7 0.416 0.381 3.99 0.329 5180 0.684 1.66 0.681 0.167 1.98 0.13 57.4 PRS_PLINK_1.58489319246107e.102 TRUE 585.1 Acute renal failure Both 8 14 11 genitourinary black 14, 8 4, 2 3, 2 3, 1 4, 3 0.265 0.92 0.773 0.112 1.3 0.286 8.85 -0.132 2.76 0.962 0.017 0.876 0.0146 5090 -0.556 2.68 0.836 0.078 0.574 0.00167 38.5 -1.27 2.39 0.597 0.224 0.282 0.251 23.8 PRS_PLINK_1.58489319246107e.102 TRUE 585.2 Renal failure NOS Both 4 6 11 genitourinary black 6, 4 2, 1 1, 1 1, 0 2, 2 -1.37 7.83 0.861 0.065 0.253 0.222 0.29 0.0861 1460 1 0 1.09 0.538 1.18 0.156 14100 1 0 1.17 0.0406 1.34 -0.0406 442 1 0 0.96 0.628 1.3 PRS_PLINK_1.58489319246107e.102 TRUE 585.3 Chronic renal failure [CKD] Both 17 15 11 genitourinary black 15, 17 4, 2 4, 4 3, 6 4, 4 0.0768 0.64 0.905 0.044 1.08 0.307 4.32 0.959 1.77 0.588 0.23 2.61 0.166 171 1.08 1.81 0.55 0.259 2.95 0.174 146 0.0195 2.49 0.994 0.003 1.02 0.00372 571 PRS_PLINK_1.58489319246107e.102 TRUE 585.31 Renal dialysis Both 0 5 11 genitourinary black 5, 0 2 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 585.32 End stage renal disease Both 1 9 11 genitourinary black 9, 1 3, 0 2, 0 2, 0 2, 1 -0.392 1.74 0.822 0.085 0.676 0.0495 82.4 -0.116 619 1 0 0.891 0.859 2.16 PRS_PLINK_1.58489319246107e.102 TRUE 585.33 Chronic Kidney Disease, Stage III Both 7 11 11 genitourinary black 11, 7 3, 2 3, 1 2, 2 3, 2 0.953 1.33 0.474 0.324 2.59 0.273 267 -0.619 349 0.999 0.001 0.539 0.678 4.05 -1.39 28.3 0.961 0.017 0.25 0.141 0.272 -0.382 2.7 0.888 0.052 0.683 0.0102 56.9 PRS_PLINK_1.58489319246107e.102 TRUE 585.34 Chronic Kidney Disease, Stage IV Both 0 10 11 genitourinary black 10, 0 3 2 2 3 PRS_PLINK_1.58489319246107e.102 TRUE 585.4 Chronic kidney disease, Stage I or II Both 10 10 11 genitourinary black 10, 10 3, 1 2, 7 2, 0 3, 2 0.166 1.02 0.871 0.06 1.18 0.193 11.2 0.0314 3.1 0.992 0.004 1.03 0.00189 6700 0.146 2510 1 0 1.16 0.368 2.72 -0.138 705 1 0 0.871 0.676 2.71 PRS_PLINK_1.58489319246107e.102 TRUE 586 Other disorders of the kidney and ureters Both 37 17 11 genitourinary black 17, 37 5, 4 4, 13 4, 9 4, 11 0.599 0.432 0.166 0.78 1.82 0.83 4.49 1.49 1.06 0.162 0.79 4.43 0.746 49.3 1.22 1.43 0.395 0.404 3.39 0.296 4700 0.901 1.19 0.45 0.347 2.46 0.322 24.9 PRS_PLINK_1.58489319246107e.102 TRUE 586.1 Anatomical abnormatilies of kidney and ureters Both 2 2 11 genitourinary black 2, 2 1, 0 0, 1 1, 1 1, 0 -0.128 567 1 0 0.88 0.447 1.16 -0.00499 748 1 0 0.995 0.917 1.07 -5.33 6.96e+08 1 0 0.00484 4.16e-16 6.26e+09 PRS_PLINK_1.58489319246107e.102 TRUE 586.11 Small kidney Both 1 0 11 genitourinary black 0, 1 PRS_PLINK_1.58489319246107e.102 TRUE 586.12 Vesicoureteral reflux Both 2 1 11 genitourinary black 1, 2 -0.12 1580 1 0 0.887 0.528 1.31 PRS_PLINK_1.58489319246107e.102 TRUE 586.2 Cyst of kidney, acquired Both 2 6 11 genitourinary black 6, 2 2, 0 1, 0 1, 2 2, 0 -0.315 76.5 0.997 0.001 0.73 1.24e-05 2740 -0.938 6060 1 0 0.391 0.366 2.72 PRS_PLINK_1.58489319246107e.102 TRUE 586.3 Vascular disorders of kidney/hypertrophy Both 0 1 11 genitourinary black 1, 0 PRS_PLINK_1.58489319246107e.102 TRUE 586.4 Stricture/obstruction of ureter Both 3 6 11 genitourinary black 6, 3 2, 2 1, 0 1, 1 2, 0 -1.98 32.2 0.951 0.022 0.138 0.00579 0.145 0.682 13700 1 0 1.98 0.0258 2.35 0.0634 2990 1 0 1.07 0.49 1.29 0.244 5040 1 0 1.28 0.398 1.31 PRS_PLINK_1.58489319246107e.102 TRUE 587 Kidney replaced by transpant Both 1 8 11 genitourinary black 8, 1 2, 0 2, 1 2, 0 2, 0 -0.134 54.6 0.998 0.001 0.875 0.32 2.7 0.0522 2380 1 0 1.05 0.431 2.65 PRS_PLINK_1.58489319246107e.102 TRUE 588 Disorders resulting from impaired renal function Both 2 10 11 genitourinary black 10, 2 3, 1 2, 0 2, 0 3, 1 0.348 2.2 0.874 0.058 1.42 1.38 1.45 0.273 3740 1 0 1.31 0.334 1.85 0.146 2510 1 0 1.16 0.368 2.72 -0.0855 1570000 1 0 0.918 0.106 6.43 PRS_PLINK_1.58489319246107e.102 TRUE 588.1 Renal osteodystrophy Both 0 5 11 genitourinary black 5, 0 2 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 588.2 Secondary hyperparathyroidism (of renal origin) Both 2 8 11 genitourinary black 8, 2 2, 1 2, 0 2, 0 2, 1 0.271 3.98 0.946 0.024 1.31 1.02 1.39 -0.219 9010 1 0 0.803 0.75 8.09 -0.121 5540 1 0 0.886 0.458 1.51 0.1 2930 1 0 1.11 0.278 7 PRS_PLINK_1.58489319246107e.102 TRUE 589 Abnormal results of function study of kidney Both 5 8 11 genitourinary black 8, 5 2, 0 2, 2 2, 2 2, 1 0.151 2.78 0.957 0.019 1.16 0.0183 80.1 2.8 2720 0.999 0 16.4 0.000155 4630000 -0.176 2290 1 0 0.838 0.307 2.5 -1.06 7060 1 0 0.348 0.00937 9.52 PRS_PLINK_1.58489319246107e.102 TRUE 590 Pyelonephritis Both 4 8 11 genitourinary black 8, 4 2, 0 2, 0 2, 1 2, 3 0.795 2.08 0.702 0.154 2.22 0.124 2.48 0.00632 77.8 1 0 1.01 0.749 1.45 -0.0113 744 1 0 0.989 0.52 2.04 PRS_PLINK_1.58489319246107e.102 TRUE 591 Urinary tract infection Both 25 31 11 genitourinary black 31, 25 8, 4 8, 7 7, 8 8, 5 -0.15 0.332 0.651 0.187 0.86 0.451 1.59 0.867 1.21 0.474 0.324 2.38 0.268 43.3 0.37 0.973 0.704 0.152 1.45 0.267 8.83 0.356 1.27 0.779 0.109 1.43 0.161 14.9 PRS_PLINK_1.58489319246107e.102 TRUE 592 Cystitis and urethritis Both 9 15 11 genitourinary black 15, 9 4, 4 4, 3 3, 1 4, 1 0.173 0.735 0.814 0.089 1.19 0.312 4.78 1.5 1.88 0.425 0.372 4.5 0.0539 29100 -0.383 2.72 0.888 0.052 0.682 0.0084 28600 0.629 2.12 0.767 0.115 1.88 0.0714 10800 PRS_PLINK_1.58489319246107e.102 TRUE 592.1 Cystitis Both 9 14 11 genitourinary black 14, 9 4, 4 3, 3 3, 1 4, 1 0.0548 0.746 0.941 0.026 1.06 0.261 4.51 1.62 1.81 0.372 0.429 5.03 0.395 271 -0.383 2.72 0.888 0.052 0.682 0.0084 28600 0.629 2.12 0.767 0.115 1.88 0.0714 10800 PRS_PLINK_1.58489319246107e.102 TRUE 592.11 Acute cystitis Both 6 10 11 genitourinary black 10, 6 3, 4 2, 1 2, 0 3, 1 1.63 1.86 0.381 0.419 5.11 0.455 328000 -0.238 6.52 0.971 0.013 0.789 0.248 2.03 -0.274 80.4 0.997 0.001 0.76 0.674 0.854 1.02 2.28 0.655 0.184 2.77 0.115 57.9 PRS_PLINK_1.58489319246107e.102 TRUE 592.12 Chronic cystitis Both 2 3 11 genitourinary black 3, 2 1, 0 1, 0 0, 1 1, 1 -0.0166 5940000 1 0 0.984 0.402 1.78 -0.00213 47 1 0 0.998 0.957 1.04 9.4e-05 2870 1 0 1 0.396 6.24 PRS_PLINK_1.58489319246107e.102 TRUE 592.13 Chronic interstitial cystitis Both 1 7 11 genitourinary black 7, 1 2, 1 2, 0 1, 0 2, 0 0.0215 521 1 0 1.02 0.836 1.36 0.213 4130 1 0 1.24 0.648 1.55 -0.272 2760 1 0 0.762 0.0173 15.3 0.171 3380 1 0 1.19 0.716 1.21 PRS_PLINK_1.58489319246107e.102 TRUE 592.2 Urethritis and urethral syndrome Both 2 1 11 genitourinary black 1, 2 0.198 11.6 0.986 0.006 1.22 0.816 1.37 PRS_PLINK_1.58489319246107e.102 TRUE 593 Hematuria Both 17 29 11 genitourinary black 29, 17 8, 4 7, 7 7, 3 7, 3 -0.393 0.388 0.311 0.507 0.675 0.31 1.36 0.734 1.29 0.57 0.244 2.08 0.154 36.3 -0.222 1.2 0.853 0.069 0.801 0.0796 8.71 -0.605 1.37 0.659 0.181 0.546 0.0135 5.72 PRS_PLINK_1.58489319246107e.102 TRUE 593.1 Gross hematuria Both 6 16 11 genitourinary black 16, 6 4, 2 4, 2 4, 1 4, 1 -0.0377 0.795 0.962 0.017 0.963 0.189 8.51 -1.65 1.99 0.408 0.39 0.193 0.00387 3.62 -0.585 2.06 0.776 0.11 0.557 0.0207 11.8 0.765 2.92 0.793 0.1 2.15 0.011 215 PRS_PLINK_1.58489319246107e.102 TRUE 593.2 Microscopic hematuria Both 6 9 11 genitourinary black 9, 6 3, 4 2, 1 2, 1 2, 0 0.466 1.27 0.713 0.147 1.59 0.244 39.1 -3.97 68.4 0.954 0.021 0.0188 0.0125 0.029 0.912 17.3 0.958 0.019 2.49 2.26 2.75 -0.0954 17500000 1 0 0.909 0.113 12 PRS_PLINK_1.58489319246107e.102 TRUE 594 Urinary calculus Both 13 43 11 genitourinary black 43, 13 10, 1 11, 4 10, 6 11, 2 0.347 0.424 0.414 0.383 1.41 0.643 3.51 1.35 1.25 0.281 0.551 3.85 0.485 180 1.45 1.2 0.227 0.643 4.25 0.561 151 -0.02 1.55 0.99 0.005 0.98 0.0228 19.5 PRS_PLINK_1.58489319246107e.102 TRUE 594.1 Calculus of kidney Both 13 43 11 genitourinary black 43, 13 10, 1 11, 4 10, 6 11, 2 0.347 0.424 0.414 0.383 1.41 0.643 3.51 1.35 1.25 0.281 0.551 3.85 0.485 180 1.45 1.2 0.227 0.643 4.25 0.561 151 -0.02 1.55 0.99 0.005 0.98 0.0228 19.5 PRS_PLINK_1.58489319246107e.102 TRUE 594.2 Calculus of lower urinary tract Both 1 4 11 genitourinary black 4, 1 1, 0 1, 0 1, 1 1, 0 1.28 1920 0.999 0 3.58 7.31e-10 1.22e+12 -0.0113 2770 1 0 0.989 0.39 1.48 PRS_PLINK_1.58489319246107e.102 TRUE 594.3 Calculus of ureter Both 2 17 11 genitourinary black 17, 2 5, 0 4, 1 4, 0 4, 1 -0.473 0.841 0.574 0.241 0.623 0.201 3.87 -1.05 15.8 0.947 0.024 0.349 1.48e-11 6.38e+09 3.16 96.1 0.974 0.012 23.7 18.5 30 PRS_PLINK_1.58489319246107e.102 TRUE 594.8 Renal colic Both 1 5 11 genitourinary black 5, 1 2, 0 1, 0 1, 0 1, 1 0.0953 851 1 0 1.1 0.703 2.71 0.152 2540 1 0 1.16 0.562 9.34 PRS_PLINK_1.58489319246107e.102 TRUE 595 Hydronephrosis Both 4 15 11 genitourinary black 15, 4 4, 0 4, 2 3, 1 4, 1 -0.196 0.793 0.805 0.094 0.822 0.0249 4.15 0.66 2.92 0.821 0.086 1.94 0.0345 204 0.185 4040000 1 0 1.2 0.2 8.31 0.764 104 0.994 0.003 2.15 0.848 2.64 PRS_PLINK_1.58489319246107e.102 TRUE 596 Other disorders of bladder Both 5 25 11 genitourinary black 25, 5 6, 0 6, 2 6, 0 6, 3 0.237 0.511 0.642 0.192 1.27 0.505 4.39 1.34 1.9 0.481 0.318 3.82 0.155 174 0.63 2.05 0.758 0.12 1.88 0.0046 625 PRS_PLINK_1.58489319246107e.102 TRUE 596.1 Bladder neck obstruction Both 1 2 11 genitourinary black 2, 1 1, 0 0, 1 1, 0 1, 0 -1.25 26200 1 0 0.287 0.000176 76.9 -0.0109 72.2 1 0 0.989 0.793 1.19 PRS_PLINK_1.58489319246107e.102 TRUE 596.5 Functional disorders of bladder Both 5 16 11 genitourinary black 16, 5 3, 0 4, 2 4, 0 4, 3 0.991 0.986 0.315 0.502 2.69 0.439 538 -0.0752 266000 1 0 0.928 0.604 1.26 2.42 392 0.995 0.002 11.3 1.85e-06 64300000 PRS_PLINK_1.58489319246107e.102 TRUE 597 Other disorders of urethra and urinary tract Both 3 7 11 genitourinary black 7, 3 2, 1 2, 0 1, 0 2, 2 -0.049 1.76 0.978 0.01 0.952 0.0752 14 0.781 14300 1 0 2.18 0.0123 2.85 6.96e-06 7820 1 0 1 0.0846 11.8 -0.453 93800000 1 0 0.636 0.0144 43.7 PRS_PLINK_1.58489319246107e.102 TRUE 597.1 Urethral stricture (not specified as infectious) Both 2 2 11 genitourinary black 2, 2 1, 1 1, 1 1, 1 1, 1 0.0284 1440 1 0 1.03 0.783 1.17 0.118 2060 1 0 1.13 0.754 2.71 PRS_PLINK_1.58489319246107e.102 TRUE 597.2 Urinary complications NEC Both 1 8 11 genitourinary black 8, 1 1, 1 2, 0 2, 0 2, 0 0.198 9.11 0.983 0.008 1.22 0.359 5.24 0.145 881 1 0 1.16 0.686 1.74 0.0124 38.6 1 0 1.01 0.928 1.12 1.35 1.81e+08 1 0 3.85 0.121 25.8 PRS_PLINK_1.58489319246107e.102 TRUE 597.8 Urethral hypermobility/ISD Both 0 2 11 genitourinary black 2, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 598 Abnormal findings on examination of urine Both 0 2 11 genitourinary black 2, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 598.4 Other cells and casts in urine Both 0 2 11 genitourinary black 2, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 599 Other symptoms/disorders or the urinary system Both 25 35 11 genitourinary black 35, 25 8, 4 9, 8 8, 10 9, 3 -0.0354 0.309 0.909 0.042 0.965 0.544 1.7 0.862 1.03 0.405 0.393 2.37 0.396 18.9 0.313 0.951 0.742 0.13 1.37 0.235 9.76 0.536 1.29 0.679 0.168 1.71 0.197 34.7 PRS_PLINK_1.58489319246107e.102 TRUE 599.1 Urinary obstruction Both 3 6 11 genitourinary black 6, 3 2, 2 1, 0 1, 0 2, 1 -1.06 170 0.995 0.002 0.345 0.0639 0.644 -0.954 7550 1 0 0.385 0.000583 3.96 -0.244 4560 1 0 0.783 0.129 1.84 0.614 4140 1 0 1.85 0.0462 22.4 PRS_PLINK_1.58489319246107e.102 TRUE 599.2 Retention of urine Both 11 27 11 genitourinary black 27, 11 6, 3 7, 4 6, 3 7, 1 -0.197 0.373 0.597 0.224 0.821 0.4 1.57 1.78 1.64 0.277 0.557 5.94 0.384 3020 0.79 1.79 0.66 0.181 2.2 0.000587 992 -0.184 1.54 0.905 0.043 0.832 0.0253 199 PRS_PLINK_1.58489319246107e.102 TRUE 599.3 Dysuria Both 13 27 11 genitourinary black 27, 13 6, 3 7, 3 6, 6 7, 1 -0.223 0.371 0.548 0.261 0.8 0.401 1.55 -0.127 1.16 0.913 0.04 0.881 0.0916 13.5 0.879 1.62 0.587 0.232 2.41 0.125 236 0.0753 1.9 0.968 0.014 1.08 0.0531 5080 PRS_PLINK_1.58489319246107e.102 TRUE 599.4 Urinary incontinence Both 6 24 11 genitourinary black 24, 6 5, 2 6, 1 6, 2 6, 1 0.521 0.596 0.382 0.418 1.68 0.584 18.4 1.8 2.87 0.531 0.275 6.02 0.0105 14200 -0.171 2.19 0.938 0.028 0.843 0.00326 60.7 0.982 2.66 0.712 0.147 2.67 0.0355 13700 PRS_PLINK_1.58489319246107e.102 TRUE 599.5 Frequency of urination and polyuria Both 10 31 11 genitourinary black 31, 10 7, 1 8, 3 7, 5 8, 1 -0.0166 0.431 0.969 0.014 0.984 0.416 2.43 -0.737 1.77 0.676 0.17 0.479 0.00519 12.9 -0.161 1.37 0.906 0.043 0.851 0.0265 9.51 0.285 1.83 0.876 0.057 1.33 0.0203 52000 PRS_PLINK_1.58489319246107e.102 TRUE 599.6 Oliguria and anuria Both 1 10 11 genitourinary black 10, 1 3, 0 2, 0 2, 0 3, 1 0.173 1.69 0.918 0.037 1.19 0.0688 16300 -0.0445 271 1 0 0.956 0.652 1.11 PRS_PLINK_1.58489319246107e.102 TRUE 599.7 Urethral discharge Both 0 6 11 genitourinary black 6, 0 2 1 1 2 PRS_PLINK_1.58489319246107e.102 TRUE 599.8 Other symptoms involving urinary system Both 12 28 11 genitourinary black 28, 12 6, 1 7, 5 7, 4 7, 2 0.347 0.418 0.407 0.391 1.41 0.677 3.22 1.59 1.74 0.36 0.444 4.91 0.178 6240 -0.405 1.58 0.798 0.098 0.667 0.0402 353 0.839 2.03 0.68 0.168 2.31 0.0862 22600 PRS_PLINK_1.58489319246107e.102 TRUE 599.9 Other abnormality of urination Both 5 21 11 genitourinary black 21, 5 5, 1 5, 0 5, 2 5, 2 -0.164 0.497 0.741 0.13 0.848 0.328 2.06 -0.0278 3.55 0.994 0.003 0.973 0.00321 461 0.488 1.9 0.798 0.098 1.63 0.0819 506 -1.58 4.72 0.738 0.132 0.206 5.01e-05 165000 PRS_PLINK_1.58489319246107e.102 TRUE 600 Hyperplasia of prostate Male 3 16 11 genitourinary black 16, 3 4, 1 4, 1 4, 1 4, 0 -0.528 1.07 0.622 0.206 0.59 0.0667 4.79 0.756 3.34 0.821 0.086 2.13 0.0149 27800 0.00647 2.26 0.998 0.001 1.01 0.0359 30.9 -4.03 984 0.997 0.001 0.0177 0.0138 0.0228 PRS_PLINK_1.58489319246107e.102 TRUE 601 Inflammatory diseases of prostate Male 3 13 11 genitourinary black 13, 3 4, 2 3, 1 3, 0 3, 0 -0.331 0.816 0.686 0.164 0.719 0.111 8.5 -5.8 22 0.792 0.101 0.00304 1.33e-16 1.11e+12 2.02 10.6 0.848 0.071 7.56 5.43e-07 1.26e+08 -0.559 10.2 0.957 0.019 0.572 0.0112 27.1 PRS_PLINK_1.58489319246107e.102 TRUE 601.1 Prostatitis Male 3 5 11 genitourinary black 5, 3 2, 3 1, 0 1, 0 1, 0 -0.386 33.2 0.991 0.004 0.68 0.278 1.43 0.325 1390 1 0 1.38 0.403 2.05 0.0982 448 1 0 1.1 0.639 2.4 0.242 135 0.999 0.001 1.27 0.286 3.08 PRS_PLINK_1.58489319246107e.102 TRUE 601.11 Acute prostatitis Male 1 1 11 genitourinary black 1, 1 0.0256 57.4 1 0 1.03 0.941 1.13 PRS_PLINK_1.58489319246107e.102 TRUE 601.12 Chronic prostatitis Male 0 1 11 genitourinary black 1, 0 PRS_PLINK_1.58489319246107e.102 TRUE 601.3 Orchitis and epididymitis Male 0 4 11 genitourinary black 4, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 601.4 Balanoposthitis Male 0 3 11 genitourinary black 3, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 602 Other disorders of prostate Male 1 3 11 genitourinary black 3, 1 1, 0 1, 0 1, 1 1, 0 0.0969 1320 1 0 1.1 0.757 1.3 0.196 9840 1 0 1.22 0.368 12.9 PRS_PLINK_1.58489319246107e.102 TRUE 602.3 Dysplasia of prostate Male 0 1 11 genitourinary black 1, 0 PRS_PLINK_1.58489319246107e.102 TRUE 603 Other disorders of testis Male 0 7 11 genitourinary black 7, 0 2 2 1 2 PRS_PLINK_1.58489319246107e.102 TRUE 603.1 Hydrocele Male 0 4 11 genitourinary black 4, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 603.2 Spermatocele Male 0 5 11 genitourinary black 5, 0 2 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 604 Disorders of penis Male 2 6 11 genitourinary black 6, 2 2, 0 1, 1 1, 1 2, 0 0.0481 61.8 0.999 0 1.05 0.51 0.599 2.48 19800 1 0 11.9 7.01e-23 4.3e+18 0.914 2690 1 0 2.5 0.548 5.3 PRS_PLINK_1.58489319246107e.102 TRUE 604.3 Peyronie's disease Male 1 1 11 genitourinary black 1, 1 0.00792 101 1 0 1.01 0.878 1.18 PRS_PLINK_1.58489319246107e.102 TRUE 605 Erectile dysfunction [ED] Male 12 11 11 genitourinary black 11, 12 3, 9 3, 0 2, 1 3, 2 -0.997 0.785 0.204 0.691 0.369 0.0459 1.41 -2.76 3.22 0.392 0.407 0.0635 2.04e-06 3610 0.238 3.54 0.946 0.024 1.27 1.31e-05 4140 -1.01 1.57 0.521 0.283 0.365 0.014 4.88 PRS_PLINK_1.58489319246107e.102 TRUE 608 Other disorders of male genital organs Male 3 14 11 genitourinary black 14, 3 4, 1 3, 2 3, 0 4, 0 -0.747 0.771 0.332 0.479 0.474 0.151 1.61 -2.05 8.13 0.801 0.097 0.128 3.58e-05 18300 -0.573 61.9 0.993 0.003 0.564 0.0312 32.3 0.436 3.99 0.913 0.04 1.55 0.0033 666 PRS_PLINK_1.58489319246107e.102 TRUE 609 Male infertility and abnormal spermatozoa Male 2 5 11 genitourinary black 5, 2 2, 0 1, 0 1, 2 1, 0 -0.623 11200 1 0 0.536 0.0043 7.11 -0.914 20500 1 0 0.401 1.11e-13 46.9 PRS_PLINK_1.58489319246107e.102 TRUE 609.1 Infertility, male Male 2 5 11 genitourinary black 5, 2 2, 0 1, 0 1, 0 1, 2 -0.338 10200 1 0 0.713 0.0324 6.73 33.4 1.28e+09 1 0 3.32e+14 4.56e-39 7.25e+90 PRS_PLINK_1.58489319246107e.102 TRUE 609.11 Azoospermia and oligospermia Male 1 1 11 genitourinary black 1, 1 -0.0218 387 1 0 0.978 0.533 6.7 PRS_PLINK_1.58489319246107e.102 TRUE 609.2 Abnormal spermatozoa Male 0 2 11 genitourinary black 2, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 610 Benign mammary dysplasias Female 4 14 11 genitourinary black 14, 4 3, 0 3, 1 3, 2 4, 1 0.623 0.759 0.411 0.386 1.86 0.498 8.08 -1.26 453 0.998 0.001 0.283 0.407 17.2 1.53 24300000 1 0 4.63 0.000833 20000 -2.1 23.5 0.929 0.032 0.122 1.42e-05 3030 PRS_PLINK_1.58489319246107e.102 TRUE 610.1 Cystic mastopathy Female 3 8 11 genitourinary black 8, 3 1, 0 2, 0 2, 1 2, 2 0.296 1.57 0.851 0.07 1.34 0.0965 23 -0.196 3460 1 0 0.822 0.791 1.71 0.0176 320 1 0 1.02 0.787 1.36 PRS_PLINK_1.58489319246107e.102 TRUE 610.2 Fibroadenosis of breast Female 0 1 11 genitourinary black 1, 0 PRS_PLINK_1.58489319246107e.102 TRUE 610.4 Benign neoplasm of breast Female 2 14 11 genitourinary black 14, 2 3, 0 3, 1 3, 0 4, 1 0.715 0.75 0.341 0.467 2.04 0.684 9.78 -1.26 453 0.998 0.001 0.283 0.407 17.2 -2.1 23.5 0.929 0.032 0.122 1.42e-05 3030 PRS_PLINK_1.58489319246107e.102 TRUE 610.8 Other specified benign mammary dysplasias Female 2 7 11 genitourinary black 7, 2 1, 0 2, 0 1, 0 2, 2 1.22 2.47 0.621 0.207 3.39 0.137 308 -0.169 1570 1 0 0.844 0.341 1.78 PRS_PLINK_1.58489319246107e.102 TRUE 611 Abnormal findings on mammogram or breast exam Both 10 17 11 genitourinary black 17, 10 4, 4 4, 1 4, 3 4, 2 -0.00968 0.841 0.991 0.004 0.99 0.191 11.8 0.468 2.1 0.824 0.084 1.6 0.0319 645 -1.54 2.61 0.556 0.255 0.215 0.000365 28.6 2.52 3.57 0.481 0.318 12.4 8.67e-05 32500 PRS_PLINK_1.58489319246107e.102 TRUE 611.1 Abnormal mammogram Both 8 14 11 genitourinary black 14, 8 3, 4 3, 1 3, 3 4, 0 -0.016 0.899 0.986 0.006 0.984 0.192 8.5 -0.00234 3.12 0.999 0 0.998 0.0086 1910 -1.53 2.79 0.583 0.234 0.216 0.000293 28.9 1.66 4.02 0.68 0.168 5.24 0.000311 6030 PRS_PLINK_1.58489319246107e.102 TRUE 611.11 Mammographic microcalcification Both 2 6 11 genitourinary black 6, 2 1, 0 1, 1 1, 0 2, 1 0.0909 483 1 0 1.1 1.38 5.08 0.761 12600 1 0 2.14 0.141 2.3 -0.0694 866 1 0 0.933 0.557 1.22 PRS_PLINK_1.58489319246107e.102 TRUE 611.3 Lump or mass in breast Both 5 16 11 genitourinary black 16, 5 3, 1 4, 1 4, 1 4, 2 0.642 0.786 0.414 0.383 1.9 0.067 34.8 0.104 152 0.999 0 1.11 0.466 4.64 1.13 123 0.993 0.003 3.1 2.46e-06 2590000 0.465 852 1 0 1.59 0.631 7.2 PRS_PLINK_1.58489319246107e.102 TRUE 612 Breast conditions, congenital or relating to hormones Both 2 11 11 genitourinary black 11, 2 2, 0 3, 0 2, 1 3, 1 0.625 1.62 0.7 0.155 1.87 0.147 30.3 1.21 1.47e+08 1 0 3.34 0.0386 1620 -0.066 5520 1 0 0.936 0.595 2.2 PRS_PLINK_1.58489319246107e.102 TRUE 612.1 Galactorrhea Both 0 1 11 genitourinary black 1, 0 PRS_PLINK_1.58489319246107e.102 TRUE 612.2 Hypertrophy of breast (Gynecomastia) Both 2 6 11 genitourinary black 6, 2 1, 0 1, 0 1, 1 2, 1 0.0708 168 1 0 1.07 0.601 2.02 0.00656 42.4 1 0 1.01 0.956 1.03 -0.000215 4290 1 0 1 0.00017 148 PRS_PLINK_1.58489319246107e.102 TRUE 613 Other nonmalignant breast conditions Both 9 25 11 genitourinary black 25, 9 6, 1 6, 2 6, 2 6, 4 0.0863 0.47 0.854 0.068 1.09 0.449 2.75 -1.19 2.02 0.555 0.256 0.304 0.00817 5.77 -1.36 2.19 0.535 0.272 0.257 0.00108 26.7 -1.43 2.03 0.482 0.317 0.239 2.5e-05 6.08 PRS_PLINK_1.58489319246107e.102 TRUE 613.1 Inflammatory disease of breast Both 1 4 11 genitourinary black 4, 1 1, 0 1, 0 1, 0 1, 1 -0.228 760 1 0 0.796 0.212 2.43 -0.131 87000 1 0 0.878 0.547 2.94 PRS_PLINK_1.58489319246107e.102 TRUE 613.5 Mastodynia Both 3 14 11 genitourinary black 14, 3 4, 0 3, 0 3, 0 4, 3 1.42 1.45 0.326 0.487 4.15 0.504 2070000 2.29 5.43 0.673 0.172 9.87 0.00383 59200 PRS_PLINK_1.58489319246107e.102 TRUE 613.7 Other signs and symptoms in breast Both 4 7 11 genitourinary black 7, 4 2, 1 2, 0 1, 0 2, 3 -0.18 1.29 0.889 0.051 0.835 0.662 0.953 -0.402 8230 1 0 0.669 0.238 3.66 -0.174 7950 1 0 0.84 0.0341 10.7 -0.00842 2290000 1 0 0.992 0.87 2.04 PRS_PLINK_1.58489319246107e.102 TRUE 613.8 Other specified disorders of breast Both 0 7 11 genitourinary black 7, 0 2 2 1 2 PRS_PLINK_1.58489319246107e.102 TRUE 613.9 Breast disorder NOS Both 2 10 11 genitourinary black 10, 2 3, 1 2, 0 2, 0 3, 1 -4.14 16.6 0.802 0.096 0.0159 5.54e-11 2690000 -0.206 1710 1 0 0.814 0.732 1.39 0.0657 679 1 0 1.07 0.839 1.45 0.0162 472 1 0 1.02 0.825 1.13 PRS_PLINK_1.58489319246107e.102 TRUE 614 Inflammatory diseases of female pelvic organs Female 7 23 11 genitourinary black 23, 7 5, 2 6, 1 5, 0 6, 4 -0.239 0.542 0.659 0.181 0.787 0.282 2.12 -1.09 1.69 0.521 0.283 0.337 0.000332 6.52 -1.12 2.49 0.654 0.185 0.328 0.00356 46.2 0.581 2.41 0.81 0.092 1.79 0.0247 545 PRS_PLINK_1.58489319246107e.102 TRUE 614.1 Pelvic peritoneal adhesions, female (postoperative) (postinfection) Female 1 4 11 genitourinary black 4, 1 0, 1 1, 0 1, 0 1, 0 -0.0511 509 1 0 0.95 0.623 1.89 0.00745 46.3 1 0 1.01 0.788 1.12 0.000134 6.43 1 0 1 0.998 1 0.00654 42.9 1 0 1.01 0.876 1.15 PRS_PLINK_1.58489319246107e.102 TRUE 614.3 Pelvic inflammatory disease (PID) Female 2 4 11 genitourinary black 4, 2 1, 1 1, 0 1, 0 1, 1 1.53 421 0.997 0.001 4.63 5.73e-05 285000 -0.691 12000 1 0 0.501 0.32 8.02 0.496 5000 1 0 1.64 0.381 2.1 5.03 564 0.993 0.003 154 1.07e-05 8.38e+09 PRS_PLINK_1.58489319246107e.102 TRUE 614.31 Acute inflammatory pelvic disease Female 0 1 11 genitourinary black 1, 0 PRS_PLINK_1.58489319246107e.102 TRUE 614.32 Chronic inflammatory pelvic disease Female 1 2 11 genitourinary black 2, 1 0, 1 1, 0 0, 1 1, 0 0.116 3050 1 0 1.12 0.601 2.22 0.00431 21.7 1 0 1 0.952 1.06 PRS_PLINK_1.58489319246107e.102 TRUE 614.33 Pelvic inflammatory disease, NOS Female 1 4 11 genitourinary black 4, 1 1, 0 1, 0 1, 1 1, 0 -0.581 118 0.996 0.002 0.559 4.14e-05 55100 PRS_PLINK_1.58489319246107e.102 TRUE 614.4 Inflammatory diseases of uterus, except cervix Female 0 3 11 genitourinary black 3, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 614.5 Inflammatory disease of cervix, vagina, and vulva Female 5 23 11 genitourinary black 23, 5 5, 1 6, 1 5, 0 6, 3 0.0405 0.672 0.952 0.021 1.04 0.295 4.32 -0.109 2.21 0.961 0.017 0.896 0.017 174 -1.2 2.42 0.621 0.207 0.302 0.0036 18.3 0.77 2.51 0.759 0.12 2.16 0.0418 479 PRS_PLINK_1.58489319246107e.102 TRUE 614.51 Cervicitis and endocervicitis Female 0 4 11 genitourinary black 4, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 614.52 Vaginitis and vulvovaginitis Female 2 23 11 genitourinary black 23, 2 5, 1 6, 0 5, 0 6, 1 0.0176 0.851 0.984 0.007 1.02 0.0617 25 0.121 2.37 0.959 0.018 1.13 0.0306 284 -1.2 2.42 0.621 0.207 0.302 0.0036 18.3 1.45 4.83 0.763 0.117 4.28 5.75e-07 7530000 PRS_PLINK_1.58489319246107e.102 TRUE 614.53 Cyst or abscess of Bartholin's gland Female 2 2 11 genitourinary black 2, 2 1, 0 1, 2 1, 0 1, 2 0.54 374 0.999 0.001 1.72 0.103 25.8 0.974 99600000 1 0 2.65 0.00204 725 PRS_PLINK_1.58489319246107e.102 TRUE 614.54 Abscess or ulceration of vulva Female 1 1 11 genitourinary black 1, 1 0.000942 398 1 0 1 0.982 1.03 PRS_PLINK_1.58489319246107e.102 TRUE 615 Endometriosis Female 2 18 11 genitourinary black 18, 2 4, 1 4, 0 4, 0 5, 1 -0.126 0.723 0.861 0.065 0.881 0.00267 36.7 -0.0169 2.02 0.993 0.003 0.983 0.97 0.993 -0.859 202 0.997 0.001 0.424 2.11e-08 9230000 -1.4 3.29 0.671 0.174 0.247 0.00161 1080 PRS_PLINK_1.58489319246107e.102 TRUE 618 Genital prolapse Female 3 19 11 genitourinary black 19, 3 4, 1 5, 1 4, 0 5, 1 0.695 0.854 0.416 0.381 2 0.464 4070 -1.25 2.06 0.543 0.265 0.286 0.00553 7.66 -2.53 126 0.984 0.007 0.0793 1.13e-10 0.109 0.829 4.18 0.843 0.074 2.29 0.00382 293 PRS_PLINK_1.58489319246107e.102 TRUE 618.1 Prolapse of vaginal walls Female 1 11 11 genitourinary black 11, 1 2, 0 3, 1 2, 0 3, 0 0.733 2.17 0.736 0.133 2.08 0.0312 941 -0.148 2930 1 0 0.862 0.174 1.58 PRS_PLINK_1.58489319246107e.102 TRUE 618.2 Uterine/Uterovaginal prolapse Female 0 6 11 genitourinary black 6, 0 2 1 1 2 PRS_PLINK_1.58489319246107e.102 TRUE 618.5 Prolapse of vaginal vault after hysterectomy Female 0 3 11 genitourinary black 3, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 618.6 Vaginal enterocele, congenital or acquired Female 2 7 11 genitourinary black 7, 2 1, 0 2, 1 1, 0 2, 1 1.99 5.86 0.735 0.134 7.29 6.53 8.2 0.0857 10700 1 0 1.09 0.243 11.6 0.108 4050 1 0 1.11 0.146 24 PRS_PLINK_1.58489319246107e.102 TRUE 619 Noninflammatory female genital disorders Female 12 19 11 genitourinary black 19, 12 4, 2 5, 2 4, 6 5, 2 -0.0334 0.469 0.943 0.025 0.967 0.416 2.28 -0.193 1.65 0.907 0.042 0.824 0.0609 14.9 0.725 1.72 0.673 0.172 2.06 0.128 73.5 -2.19 2.59 0.398 0.4 0.112 0.00111 4.76 PRS_PLINK_1.58489319246107e.102 TRUE 619.1 Noninflammatory disorders of ovary, fallopian tube, and broad ligament Female 2 12 11 genitourinary black 12, 2 3, 1 3, 0 3, 0 3, 1 0.269 0.858 0.754 0.123 1.31 0.308 9.05 -0.0121 978 1 0 0.988 0.357 1.46 0.0364 10700000 1 0 1.04 0.019 81.4 0.802 9.05 0.929 0.032 2.23 0.0492 2.38 PRS_PLINK_1.58489319246107e.102 TRUE 619.2 Disorders of uterus, NEC Female 1 6 11 genitourinary black 6, 1 2, 0 1, 0 1, 0 2, 1 0.349 1290 1 0 1.42 0.0543 17.8 -0.0472 8950 1 0 0.954 0.0423 4.75 PRS_PLINK_1.58489319246107e.102 TRUE 619.3 Noninflammatory disorders of cervix Female 0 5 11 genitourinary black 5, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 619.4 Noninflammatory disorders of vagina Female 9 18 11 genitourinary black 18, 9 4, 2 4, 1 4, 4 5, 2 -0.171 0.507 0.735 0.134 0.842 0.33 2.05 -0.317 1.7 0.852 0.07 0.728 0.646 0.896 -0.604 2.78 0.828 0.082 0.547 0.00534 55.5 -1.2 2.82 0.67 0.174 0.3 0.00279 25.8 PRS_PLINK_1.58489319246107e.102 TRUE 619.5 Noninflammatory disorders of vulva and perineum Female 2 12 11 genitourinary black 12, 2 3, 0 3, 1 3, 0 3, 1 0.428 2.77 0.877 0.057 1.53 0.00425 445000 -0.0973 1390 1 0 0.907 0.329 2.47 0.113 35.6 0.997 0.001 1.12 1.57 1.5 PRS_PLINK_1.58489319246107e.102 TRUE 620 Dysplasia of female genital organs Female 0 6 11 genitourinary black 6, 0 1 1 1 2 PRS_PLINK_1.58489319246107e.102 TRUE 620.1 Dysplasia of cervix Female 0 3 11 genitourinary black 3, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 621 Endometrial hyperplasia Female 0 6 11 genitourinary black 6, 0 1 1 1 2 PRS_PLINK_1.58489319246107e.102 TRUE 622 Polyp of female genital organs Female 3 20 11 genitourinary black 20, 3 4, 0 5, 0 5, 2 5, 1 1.05 1.14 0.355 0.449 2.87 0.432 297 0.152 2.32 0.948 0.023 1.16 0.0205 82.7 5.38 11.5 0.641 0.193 217 8.23e-05 289 PRS_PLINK_1.58489319246107e.102 TRUE 622.1 Polyp of corpus uteri Female 2 14 11 genitourinary black 14, 2 3, 0 3, 0 3, 1 4, 1 0.751 1.07 0.484 0.315 2.12 0.387 2150 -0.0091 1850 1 0 0.991 0.51 1.4 1.8 287 0.995 0.002 6.04 1.04 110 PRS_PLINK_1.58489319246107e.102 TRUE 622.2 Mucous polyp of cervix Female 1 7 11 genitourinary black 7, 1 2, 0 2, 0 1, 1 2, 0 0.0855 83.8 0.999 0 1.09 0.915 1.98 -0.0505 4140 1 0 0.951 0.558 1.22 PRS_PLINK_1.58489319246107e.102 TRUE 623 Hypertrophy of female genital organs Female 0 13 11 genitourinary black 13, 0 4 3 3 3 PRS_PLINK_1.58489319246107e.102 TRUE 624 Symptoms involving female genital tract Female 4 17 11 genitourinary black 17, 4 4, 0 4, 0 4, 3 4, 1 1.6 1.08 0.14 0.853 4.93 0.812 172 1.18 3.03 0.698 0.156 3.24 0.0142 415 -1.34 4.38 0.759 0.12 0.261 9.64e-06 610 PRS_PLINK_1.58489319246107e.102 TRUE 624.1 Dystrophy of female genital tract Female 1 1 11 genitourinary black 1, 1 4.81e-05 6.83 1 0 1 0.997 1 PRS_PLINK_1.58489319246107e.102 TRUE 624.2 Atrophy of female genital tract Female 0 1 11 genitourinary black 1, 0 PRS_PLINK_1.58489319246107e.102 TRUE 624.9 stress incontinence, female Female 5 16 11 genitourinary black 16, 5 3, 0 4, 2 4, 1 4, 2 1.08 0.848 0.201 0.696 2.96 0.725 937 1.22 3.49 0.726 0.139 3.39 0.0242 1360 -0.254 770 1 0 0.776 5.48e-09 1.22e+10 -0.558 11.2 0.96 0.018 0.572 0.48 0.73 PRS_PLINK_1.58489319246107e.102 TRUE 625 Pain and other symptoms associated with female genital organs Female 11 20 11 genitourinary black 20, 11 4, 1 5, 3 5, 6 5, 1 1.54 0.816 0.0601 1.221 4.64 1.14 51.9 0.644 2.09 0.758 0.12 1.9 2.44e-05 133 0.371 1.85 0.841 0.075 1.45 0.0435 61.3 -1.34 4.38 0.759 0.12 0.261 9.63e-06 610 PRS_PLINK_1.58489319246107e.102 TRUE 625.1 Dyspareunia Female 4 14 11 genitourinary black 14, 4 3, 0 3, 1 3, 1 4, 2 1.45 0.936 0.122 0.915 4.26 0.972 231 -0.0205 672 1 0 0.98 0.782 1.19 -0.226 485 1 0 0.798 0.748 6.62 0.307 4.35 0.944 0.025 1.36 1.07 1.48 PRS_PLINK_1.58489319246107e.102 TRUE 626 Disorders of menstruation and other abnormal bleeding from female genital tract Female 15 15 11 genitourinary black 15, 15 3, 6 4, 1 3, 3 4, 5 -0.286 0.476 0.547 0.262 0.751 0.3 1.65 -4.46 3.48 0.2 0.699 0.0116 6.34e-09 1.27 -1.12 2.33 0.631 0.2 0.326 0.000261 44.1 -1.96 2.51 0.435 0.362 0.14 6.5e-05 5.43 PRS_PLINK_1.58489319246107e.102 TRUE 626.1 Irregular menstrual cycle/bleeding Female 13 15 11 genitourinary black 15, 13 3, 5 4, 0 3, 3 4, 5 -0.288 0.48 0.548 0.261 0.749 0.296 1.63 -2.91 2.6 0.263 0.58 0.0546 5.48e-07 1.67 -1.08 2.34 0.643 0.192 0.338 0.00027 44.9 -1.97 2.51 0.434 0.362 0.14 6.47e-05 5.29 PRS_PLINK_1.58489319246107e.102 TRUE 626.11 Absent or infrequent menstruation Female 7 10 11 genitourinary black 10, 7 2, 2 2, 2 2, 1 3, 2 0.235 0.781 0.764 0.117 1.26 0.355 5.51 -0.0973 725 1 0 0.907 0.853 1.35 0.198 2300 1 0 1.22 0.108 5.99 -0.429 372 0.999 0 0.651 4.82e-08 186 PRS_PLINK_1.58489319246107e.102 TRUE 626.12 Excessive or frequent menstruation Female 9 13 11 genitourinary black 13, 9 3, 3 3, 0 3, 3 3, 3 -0.18 0.628 0.774 0.111 0.835 0.263 2.38 1.22 164 0.994 0.003 3.37 1.18e-06 1.62 0.243 4.82 0.96 0.018 1.27 5.11e-05 11800 -0.939 3.43 0.784 0.106 0.391 0.000724 258 PRS_PLINK_1.58489319246107e.102 TRUE 626.13 Irregular menstrual cycle Female 6 13 11 genitourinary black 13, 6 3, 2 3, 0 3, 3 3, 1 -0.838 0.777 0.281 0.551 0.433 0.0591 1.4 -1.06 1010 0.999 0 0.347 0.0168 1 -7.35 23.7 0.757 0.121 0.000644 0.000439 0.000913 -7.54 183 0.967 0.015 0.000532 1.61e-30 0.0352 PRS_PLINK_1.58489319246107e.102 TRUE 626.14 Irregular menstrual bleeding Female 3 11 11 genitourinary black 11, 3 2, 0 3, 0 2, 1 3, 2 -0.204 1.19 0.864 0.064 0.816 0.0874 28.8 -0.0941 5710 1 0 0.91 0.763 2.65 -1.41 9220 1 0 0.245 0.00375 8.63 PRS_PLINK_1.58489319246107e.102 TRUE 626.15 Infertility, female, associated with anovulation Female 2 6 11 genitourinary black 6, 2 1, 1 1, 0 1, 0 2, 1 0.543 140 0.997 0.001 1.72 0.863 7.98 -0.213 2310 1 0 0.808 0.0119 1.76 -0.0954 1140 1 0 0.909 0.36 1.27 -0.378 3490 1 0 0.685 0.0093 29.3 PRS_PLINK_1.58489319246107e.102 TRUE 626.2 Dysmenorrhea Female 5 12 11 genitourinary black 12, 5 2, 3 3, 0 3, 0 3, 2 0.821 0.905 0.365 0.438 2.27 0.5 46.8 -0.0011 497 1 0 0.999 0.349 3.1 0.235 1510 1 0 1.27 0.081 10.9 1.8 2.88 0.533 0.274 6.04 0.155 1430 PRS_PLINK_1.58489319246107e.102 TRUE 626.4 Premenstrual tension syndromes Female 1 2 11 genitourinary black 2, 1 1, 0 0, 1 1, 0 1, 0 -0.311 3450 1 0 0.733 0.582 1.88 -0.00996 155 1 0 0.99 0.982 1.02 PRS_PLINK_1.58489319246107e.102 TRUE 626.8 Infertility, female Female 3 8 11 genitourinary black 8, 3 1, 1 2, 1 2, 0 2, 1 -0.568 1.99 0.775 0.111 0.567 0.00023 16.5 0.0135 92.4 1 0 1.01 0.855 1.14 0.0598 1440 1 0 1.06 0.693 1.72 -0.378 3490 1 0 0.685 0.0093 29.3 PRS_PLINK_1.58489319246107e.102 TRUE 627 Menopausal and postmenopausal disorders Female 7 14 11 genitourinary black 14, 7 3, 3 3, 1 3, 1 4, 2 -0.0925 0.592 0.876 0.058 0.912 0.288 2.33 1.87 4.97 0.706 0.151 6.51 5.21 7.76 -7.89 17.6 0.654 0.184 0.000374 2.26e-16 8640000 -0.951 3.65 0.795 0.1 0.387 0.000807 175 PRS_PLINK_1.58489319246107e.102 TRUE 627.1 Postmenopausal bleeding Female 3 8 11 genitourinary black 8, 3 2, 0 2, 1 2, 1 2, 1 3.89 4.44 0.381 0.419 48.9 0.0755 4460000 0.0516 898 1 0 1.05 0.87 1.43 0.183 2590 1 0 1.2 0.145 1.25 0.0593 2440 1 0 1.06 0.777 1.99 PRS_PLINK_1.58489319246107e.102 TRUE 627.2 Symptomatic menopause Female 2 14 11 genitourinary black 14, 2 3, 1 3, 0 3, 1 4, 0 -0.834 1.08 0.439 0.357 0.434 0.0194 6.75 -9.71 37600 1 0 6.06e-05 9.46e-20 1.38e+08 -1.17 90.2 0.99 0.005 0.311 0.331 0.262 -1.54 2580 1 0 0.215 0.0277 103 PRS_PLINK_1.58489319246107e.102 TRUE 627.21 Symptomatic artificial menopause Female 0 3 11 genitourinary black 3, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 627.22 Need for Hormone replacement therapy (postmenopausal) Female 0 2 11 genitourinary black 2, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 627.3 Postmenopausal atrophic vaginitis Female 2 8 11 genitourinary black 8, 2 2, 1 2, 1 2, 0 2, 0 -3.32 10.7 0.757 0.121 0.0361 8.44e-10 117000 -0.415 1910 1 0 0.66 0.126 2.97 0.0386 1040 1 0 1.04 0.879 1.35 -0.222 8680 1 0 0.801 0.676 3.34 PRS_PLINK_1.58489319246107e.102 TRUE 627.4 Premenopausal menorrhagia Female 4 3 11 genitourinary black 3, 4 1, 1 1, 0 0, 1 1, 2 0.000267 142 1 0 1 0.81 1.11 11.4 2.04e+09 1 0 85500 2.23e-20 1.88e+32 13.5 76100 1 0 703000 5.27e-21 8.86e+28 0.437 2140 1 0 1.55 0.0698 30.5 PRS_PLINK_1.58489319246107e.102 TRUE 627.5 Premature menopause and other ovarian failure Female 1 3 11 genitourinary black 3, 1 0, 1 1, 0 1, 0 0, 1 0.0441 940 1 0 1.05 0.744 1.53 0.0222 67.7 1 0 1.02 0.823 1.19 0.0112 45.3 1 0 1.01 0.782 1.17 PRS_PLINK_1.58489319246107e.102 TRUE 628 Ovarian cyst Female 3 14 11 genitourinary black 14, 3 3, 2 3, 0 3, 0 4, 1 0.136 0.695 0.845 0.073 1.15 0.352 4.37 -0.105 2400 1 0 0.9 0.642 1.94 -4.02 2e+08 1 0 0.0179 4.04e-14 2.95e+10 -3.37 5.46 0.536 0.271 0.0343 5.93e-06 65.4 PRS_PLINK_1.58489319246107e.102 TRUE 634 Miscarriage; stillbirth Female 4 12 12 pregnancy complications royalblue4 12, 4 2, 1 3, 0 3, 1 3, 2 -0.166 0.924 0.857 0.067 0.847 0.149 3.96 0.123 1060 1 0 1.13 0.631 4.35 -0.756 1370 1 0 0.47 0.0241 6.9 -0.891 44.2 0.984 0.007 0.41 0.00579 28.9 PRS_PLINK_1.58489319246107e.102 TRUE 634.1 Missed abortion/Hydatidiform mole Female 0 5 12 pregnancy complications royalblue4 5, 0 2 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 635 Hemorrhage during pregnancy; childbirth and postpartum Female 2 8 12 pregnancy complications royalblue4 8, 2 2, 0 2, 0 2, 1 2, 1 -0.539 10.8 0.96 0.018 0.584 0.545 0.631 -0.118 2670 1 0 0.889 0.341 1.98 0.182 3160 1 0 1.2 0.256 64.3 PRS_PLINK_1.58489319246107e.102 TRUE 635.2 Antepartum hemorrhage, abruptio placentae, and placenta previa Female 1 6 12 pregnancy complications royalblue4 6, 1 2, 0 1, 0 1, 0 2, 1 0.0789 2610000 1 0 1.08 0.255 3.41 0.182 3160 1 0 1.2 0.256 64.3 PRS_PLINK_1.58489319246107e.102 TRUE 635.3 Placenta previa and abruptio placenta Female 2 3 12 pregnancy complications royalblue4 3, 2 1, 0 1, 0 0, 1 1, 1 -0.314 292 0.999 0 0.731 0.0566 6.48 -0.00268 55 1 0 0.997 0.878 1.06 0.217 8290 1 0 1.24 0.412 18.7 PRS_PLINK_1.58489319246107e.102 TRUE 636 Early or threatened labor; hemorrhage in early pregnancy Female 4 11 12 pregnancy complications royalblue4 11, 4 2, 1 3, 0 2, 2 3, 1 -0.0644 0.843 0.939 0.027 0.938 0.196 4.15 -0.0958 2160 1 0 0.909 0.31 3.17 -0.044 1040 1 0 0.957 0.367 1.35 0.0145 1410 1 0 1.01 0.191 5.7 PRS_PLINK_1.58489319246107e.102 TRUE 636.1 Threatened premature labor Female 0 7 12 pregnancy complications royalblue4 7, 0 2 2 1 2 PRS_PLINK_1.58489319246107e.102 TRUE 636.2 Early onset of delivery Female 1 8 12 pregnancy complications royalblue4 8, 1 1, 0 2, 0 2, 1 2, 0 -1.11 220 0.996 0.002 0.33 1.64e-07 140 -0.0164 863 1 0 0.984 0.702 1.34 PRS_PLINK_1.58489319246107e.102 TRUE 636.3 Hemorrhage in early pregnancy Female 3 5 12 pregnancy complications royalblue4 5, 3 2, 1 1, 0 1, 0 1, 2 -0.244 167 0.999 0.001 0.783 0.23 0.535 -1.33 5750 1 0 0.265 1.4e-05 9480 -0.0711 1770 1 0 0.931 0.552 1.47 2.5 1010 0.998 0.001 12.2 0.00277 32900 PRS_PLINK_1.58489319246107e.102 TRUE 636.8 Cervical incompetence Female 0 2 12 pregnancy complications royalblue4 2, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 637 Short gestation; low birth weight; and fetal growth retardation Both 0 1 12 pregnancy complications royalblue4 1, 0 PRS_PLINK_1.58489319246107e.102 TRUE 642 Hypertension complicating pregnancy, childbirth, and the puerperium Female 2 11 12 pregnancy complications royalblue4 11, 2 2, 0 3, 1 2, 1 3, 0 0.0816 1.15 0.943 0.025 1.09 0.124 40.5 0.27 727 1 0 1.31 0.0899 21.5 2.31 1750 0.999 0 10.1 0.00187 527000 PRS_PLINK_1.58489319246107e.102 TRUE 642.1 Preeclampsia and eclampsia Female 2 5 12 pregnancy complications royalblue4 5, 2 2, 1 1, 1 1, 0 1, 0 -0.119 532 1 0 0.888 0.32 0.808 0.321 9240 1 0 1.38 0.125 3.17 -0.00349 186 1 0 0.997 0.895 1.07 -0.18 6390 1 0 0.836 0.324 1.89 PRS_PLINK_1.58489319246107e.102 TRUE 643 Excessive vomiting in pregnancy Female 1 7 12 pregnancy complications royalblue4 7, 1 2, 0 2, 0 1, 0 2, 1 0.573 94.7 0.995 0.002 1.77 2.37 7.72 0.0347 2670 1 0 1.04 0.184 8.4 PRS_PLINK_1.58489319246107e.102 TRUE 643.1 Hyperemesis gravidarum Female 0 3 12 pregnancy complications royalblue4 3, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 644 Anemia during pregnancy Female 1 3 12 pregnancy complications royalblue4 3, 1 1, 0 1, 0 1, 1 1, 0 -0.0481 7440 1 0 0.953 0.148 4.87 0.128 63200 1 0 1.14 0.318 3.88 PRS_PLINK_1.58489319246107e.102 TRUE 646 Other complications of pregnancy NEC Female 2 11 12 pregnancy complications royalblue4 11, 2 3, 0 3, 1 2, 0 3, 1 1.09 1.6 0.496 0.305 2.98 0.212 304 0.0305 476 1 0 1.03 0.65 2.38 -0.602 284 0.998 0.001 0.548 0.0626 0.436 PRS_PLINK_1.58489319246107e.102 TRUE 647 Infectious and parasitic complications affecting pregnancy Female 0 3 12 pregnancy complications royalblue4 3, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 647.1 Infections of genitourinary tract during pregnancy Female 1 5 12 pregnancy complications royalblue4 5, 1 2, 0 1, 0 1, 0 1, 1 -0.214 421 1 0 0.808 0.27 2.64 0.00295 428 1 0 1 0.0371 85.2 PRS_PLINK_1.58489319246107e.102 TRUE 647.3 Major puerperal infection Female 0 1 12 pregnancy complications royalblue4 1, 0 PRS_PLINK_1.58489319246107e.102 TRUE 649 Other conditions or status of the mother complicating pregnancy, childbirth, or the puerperium Female 3 12 12 pregnancy complications royalblue4 12, 3 2, 0 3, 0 3, 1 3, 2 1.06 1.35 0.433 0.363 2.89 0.247 4030 0.305 1080 1 0 1.36 0.118 18.6 -1.35 1090 0.999 0 0.26 0.0143 0.227 PRS_PLINK_1.58489319246107e.102 TRUE 649.1 Diabetes or abnormal glucose tolerance complicating pregnancy Female 3 13 12 pregnancy complications royalblue4 13, 3 3, 0 3, 0 3, 1 3, 2 -2.13 2.37 0.37 0.432 0.119 1.17e-05 71 -0.0151 64.7 1 0 0.985 0.0505 14.8 -1.5 6830000 1 0 0.222 9.51e-05 63.5 PRS_PLINK_1.58489319246107e.102 TRUE 653 Problems associated with amniotic cavity and membranes Female 1 9 12 pregnancy complications royalblue4 9, 1 2, 0 2, 0 2, 0 2, 1 1.1 1.92 0.565 0.248 3.01 0.255 85.8 -0.16 6e+06 1 0 0.852 0.0673 21 PRS_PLINK_1.58489319246107e.102 TRUE 654.1 Abnormality of organs and soft tissues of pelvis complicating pregnancy, childbirth, or the puerperium Female 0 4 12 pregnancy complications royalblue4 4, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 654.2 Rhesus isoimmunization in pregnancy Female 0 3 12 pregnancy complications royalblue4 3, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 655 Known or suspected fetal abnormality affecting management of mother Female 3 15 12 pregnancy complications royalblue4 15, 3 3, 1 4, 1 3, 0 4, 1 -0.0563 0.732 0.939 0.027 0.945 0.24 3.52 -2.56 126 0.984 0.007 0.0776 5e-04 1.26 -0.264 3930 1 0 0.768 0.0959 3.33 -1.64 23.7 0.945 0.025 0.193 0.178 0.207 PRS_PLINK_1.58489319246107e.102 TRUE 655.1 Abnormality in fetal heart rate or rhythm Female 2 12 12 pregnancy complications royalblue4 12, 2 2, 0 3, 1 3, 0 3, 1 1.66 1.71 0.331 0.481 5.26 0.376 1560 0.228 775 1 0 1.26 0.446 1.44 -1.42 1320 0.999 0 0.243 1.28e-05 2800 PRS_PLINK_1.58489319246107e.102 TRUE 656 Other perinatal conditions of fetus or newborn Both 2 13 12 pregnancy complications royalblue4 13, 2 4, 0 3, 1 3, 0 3, 1 2.57 2.33 0.27 0.569 13.1 0.489 7090000 -5.84 9720 1 0 0.00291 1.29e-12 44.5 0.647 33.7 0.985 0.007 1.91 1.05 3.48 PRS_PLINK_1.58489319246107e.102 TRUE 656.2 Respiratory conditions of fetus and newborn Both 0 3 12 pregnancy complications royalblue4 3, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 669 Complications of labor and delivery NEC Female 1 15 12 pregnancy complications royalblue4 15, 1 3, 0 4, 1 3, 0 4, 0 0.0355 1.13 0.975 0.011 1.04 0.00502 762 5.31 124 0.966 0.015 202 256 401 PRS_PLINK_1.58489319246107e.102 TRUE 671 Venous/cerebrovascular complications embolism in pregnancy and the puerperium Female 0 6 12 pregnancy complications royalblue4 6, 0 2 1 1 2 PRS_PLINK_1.58489319246107e.102 TRUE 674 Other complications of the puerperium NEC Female 0 4 12 pregnancy complications royalblue4 4, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 676 Other disorders of the breast associated with childbirth and disorders of lactation Female 0 5 12 pregnancy complications royalblue4 5, 0 2 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 681 Superficial cellulitis and abscess Both 13 50 13 dermatologic firebrick 50, 13 13, 3 12, 1 12, 8 13, 0 -0.252 0.361 0.486 0.314 0.778 0.383 1.54 -0.125 1.11 0.91 0.041 0.882 0.0738 14.9 0.727 0.871 0.404 0.393 2.07 0.447 11.1 -0.111 1.43 0.938 0.028 0.895 0.0164 139 PRS_PLINK_1.58489319246107e.102 TRUE 681.1 Cellulitis and abscess of fingers/toes Both 4 24 13 dermatologic firebrick 24, 4 6, 1 6, 1 6, 1 6, 0 -0.573 0.613 0.35 0.456 0.564 0.0564 1.74 -0.312 1.65 0.85 0.07 0.732 0.0239 191 -0.624 1.82 0.731 0.136 0.536 0.0021 16.3 -0.138 2.37 0.954 0.021 0.871 0.00316 82.9 PRS_PLINK_1.58489319246107e.102 TRUE 681.2 Cellulitis and abscess of face/neck Both 2 21 13 dermatologic firebrick 21, 2 6, 0 5, 0 5, 1 5, 1 0.0593 0.685 0.931 0.031 1.06 0.202 13.8 0.342 3.02 0.91 0.041 1.41 0.00232 2650 -0.0578 6.71 0.993 0.003 0.944 0.0136 78.3 PRS_PLINK_1.58489319246107e.102 TRUE 681.3 Cellulitis and abscess of arm/hand Both 5 30 13 dermatologic firebrick 30, 5 8, 1 7, 1 7, 0 8, 3 0.169 0.582 0.771 0.113 1.18 0.378 3.71 2.66 2.56 0.298 0.526 14.3 0.286 17400 0.157 2.41 0.948 0.023 1.17 0.0125 1710 -2.08 2.45 0.395 0.403 0.125 0.000147 9.52 PRS_PLINK_1.58489319246107e.102 TRUE 681.5 Cellulitis and abscess of leg, except foot Both 5 31 13 dermatologic firebrick 31, 5 8, 1 8, 1 7, 0 8, 3 0.463 0.616 0.453 0.344 1.59 0.4 8.4 2.16 2.21 0.327 0.485 8.69 0.194 9690 0.195 1.9 0.918 0.037 1.22 0.0202 393 0.663 2.16 0.759 0.12 1.94 0.0139 90400 PRS_PLINK_1.58489319246107e.102 TRUE 681.6 Cellulitis and abscess of foot, toe Both 5 26 13 dermatologic firebrick 26, 5 7, 1 6, 1 6, 0 7, 3 0.532 0.732 0.467 0.33 1.7 0.371 9.61 2.16 2.28 0.345 0.462 8.63 0.232 9030 0.409 2.89 0.887 0.052 1.51 0.0069 4920 -0.122 1.55 0.938 0.028 0.885 0.0435 71.6 PRS_PLINK_1.58489319246107e.102 TRUE 681.7 Cellulitis and abscess of trunk Both 2 27 13 dermatologic firebrick 27, 2 7, 1 7, 0 6, 0 7, 1 0.0759 0.747 0.919 0.037 1.08 0.0672 19.9 -0.523 1.69 0.757 0.121 0.593 0.00868 32.2 0.274 2.23 0.902 0.045 1.32 0.00406 108 0.184 1.92 0.924 0.034 1.2 0.0314 40.1 PRS_PLINK_1.58489319246107e.102 TRUE 686 Other local infections of skin and subcutaneous tissue Both 2 26 13 dermatologic firebrick 26, 2 7, 0 6, 0 6, 2 7, 0 0.126 0.657 0.848 0.071 1.13 0.204 6.98 1.96 2.07 0.343 0.464 7.13 0.27 412000 PRS_PLINK_1.58489319246107e.102 TRUE 686.1 Carbuncle and furuncle Both 1 14 13 dermatologic firebrick 14, 1 4, 0 3, 0 3, 0 4, 1 0.497 1.02 0.628 0.202 1.64 0.357 24.9 -0.416 137 0.998 0.001 0.66 0.0081 4.36 PRS_PLINK_1.58489319246107e.102 TRUE 686.2 Impetigo Both 0 5 13 dermatologic firebrick 5, 0 2 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 686.3 Pilonidal cyst Both 1 6 13 dermatologic firebrick 6, 1 2, 0 1, 0 1, 0 2, 1 4.71 1250 0.997 0.001 111 7.65e-06 4.37e+09 2.36 2000 0.999 0 10.6 1.99e-12 4.63e+11 PRS_PLINK_1.58489319246107e.102 TRUE 686.4 Pyogenic granuloma Both 0 3 13 dermatologic firebrick 3, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 686.5 Pyoderma Both 1 2 13 dermatologic firebrick 2, 1 1, 0 1, 1 1, 0 1, 1 -0.0391 44.7 0.999 0 0.962 0.93 1.23 -0.019 22.4 0.999 0 0.981 0.966 1.08 PRS_PLINK_1.58489319246107e.102 TRUE 687 Symptoms affecting skin Both 4 18 13 dermatologic firebrick 18, 4 5, 0 4, 0 4, 0 5, 3 0.179 0.589 0.761 0.119 1.2 0.158 6.53 0.161 2.82 0.954 0.02 1.18 2.05e-06 18300 PRS_PLINK_1.58489319246107e.102 TRUE 687.1 Rash and other nonspecific skin eruption Both 22 36 13 dermatologic firebrick 36, 22 9, 4 9, 3 9, 6 9, 9 0.427 0.344 0.215 0.667 1.53 0.828 3.07 -0.136 1.08 0.9 0.046 0.872 0.0826 5.9 -0.217 1.14 0.849 0.071 0.805 0.0628 6.17 0.659 1.06 0.534 0.272 1.93 0.288 15.4 PRS_PLINK_1.58489319246107e.102 TRUE 687.3 Changes in skin texture Both 2 8 13 dermatologic firebrick 8, 2 2, 0 2, 0 2, 0 2, 1 0.0574 1160000 1 0 1.06 0.212 2.77 -0.497 6230 1 0 0.609 0.0693 4.53 PRS_PLINK_1.58489319246107e.102 TRUE 687.4 Disturbance of skin sensation Both 9 36 13 dermatologic firebrick 36, 9 9, 0 9, 2 9, 2 9, 5 0.593 0.485 0.221 0.656 1.81 0.774 5.47 1.05 1.53 0.494 0.307 2.84 0.113 1300 1.16 2.17 0.593 0.227 3.19 0.0144 1150 1.76 1.51 0.243 0.614 5.82 0.444 2140 PRS_PLINK_1.58489319246107e.102 TRUE 689 Disorder of skin and subcutaneous tissue NOS Both 16 48 13 dermatologic firebrick 48, 16 12, 2 12, 3 12, 7 12, 3 -0.137 0.374 0.714 0.147 0.872 0.41 1.79 0.351 1.12 0.753 0.123 1.42 0.103 24.7 2.27 1.72 0.187 0.729 9.67 0.373 1940 0.24 1.41 0.865 0.063 1.27 0.0439 46.8 PRS_PLINK_1.58489319246107e.102 TRUE 690 Erythematosquamous dermatosis Both 9 32 13 dermatologic firebrick 32, 9 7, 4 8, 1 8, 3 8, 1 0.256 0.508 0.615 0.211 1.29 0.468 4.07 -1.11 1.36 0.415 0.382 0.331 0.00614 4.53 2.68 2.21 0.224 0.649 14.6 0.42 1350000 0.0837 1.78 0.963 0.017 1.09 0.0247 1430 PRS_PLINK_1.58489319246107e.102 TRUE 690.1 Seborrheic dermatitis Both 9 32 13 dermatologic firebrick 32, 9 7, 4 8, 1 8, 3 8, 1 0.256 0.508 0.615 0.211 1.29 0.468 4.07 -1.11 1.36 0.415 0.382 0.331 0.00614 4.53 2.68 2.21 0.224 0.649 14.6 0.42 1350000 0.0837 1.78 0.963 0.017 1.09 0.0247 1430 PRS_PLINK_1.58489319246107e.102 TRUE 691 Congenital anomalies of skin Both 1 10 13 dermatologic firebrick 10, 1 3, 0 2, 1 2, 0 3, 0 -3.46 15.3 0.822 0.085 0.0315 5.91e-08 12700 0.0218 219 1 0 1.02 0.91 1.26 PRS_PLINK_1.58489319246107e.102 TRUE 691.3 Congenital pigmentary anomalies of skin Both 0 2 13 dermatologic firebrick 2, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 694 Dyschromia and Vitiligo Both 4 22 13 dermatologic firebrick 22, 4 6, 1 5, 2 5, 1 6, 0 0.518 0.781 0.508 0.295 1.68 0.442 231 -0.305 3.35 0.927 0.033 0.737 3.74e-06 2460 0.342 3.16 0.914 0.039 1.41 0.0056 1590 0.42 2.57 0.87 0.06 1.52 0.000888 112 PRS_PLINK_1.58489319246107e.102 TRUE 694.1 Vitiligo Both 1 3 13 dermatologic firebrick 3, 1 1, 1 1, 0 1, 0 1, 1 -0.353 13500 1 0 0.703 0.513 7.93 0.00122 17.5 1 0 1 0.964 1.07 0.062 244 1 0 1.06 0.847 1.39 PRS_PLINK_1.58489319246107e.102 TRUE 694.2 Other dyschromia Both 3 19 13 dermatologic firebrick 19, 3 5, 0 5, 2 4, 1 5, 0 0.64 0.869 0.461 0.336 1.9 0.414 33.6 -3.55 6.06 0.558 0.253 0.0286 3.8e-08 210 -0.152 28.6 0.996 0.002 0.859 0.736 53 PRS_PLINK_1.58489319246107e.102 TRUE 694.3 Vascular disorders of skin Both 0 1 13 dermatologic firebrick 1, 0 PRS_PLINK_1.58489319246107e.102 TRUE 695 Erythematous conditions Both 13 33 13 dermatologic firebrick 33, 13 8, 2 8, 6 8, 3 8, 2 0.272 0.412 0.508 0.294 1.31 0.615 3 0.705 1.12 0.528 0.277 2.02 0.306 25.2 0.315 1.75 0.857 0.067 1.37 0.000491 44.6 0.949 1.67 0.57 0.244 2.58 0.112 221 PRS_PLINK_1.58489319246107e.102 TRUE 695.2 Bullous dermatoses Both 0 1 13 dermatologic firebrick 1, 0 PRS_PLINK_1.58489319246107e.102 TRUE 695.3 Rosacea Both 3 18 13 dermatologic firebrick 18, 3 4, 1 4, 2 4, 0 5, 0 -0.242 0.664 0.716 0.145 0.785 0.123 2.52 0.299 2.49 0.905 0.044 1.35 0.0238 49 -0.0358 12 0.998 0.001 0.965 0.493 1.61 -0.168 15.2 0.991 0.004 0.845 0.39 0.424 PRS_PLINK_1.58489319246107e.102 TRUE 695.4 Lupus (localized and systemic) Both 3 10 13 dermatologic firebrick 10, 3 2, 0 2, 1 2, 2 3, 0 0.675 1.06 0.524 0.281 1.96 0.443 20.8 0.184 16800 1 0 1.2 0.0305 26.6 0.0588 62 0.999 0 1.06 1 1.54 PRS_PLINK_1.58489319246107e.102 TRUE 695.41 Cutaneous lupus erythematosus Both 1 3 13 dermatologic firebrick 3, 1 1, 1 1, 0 1, 1 1, 0 -0.304 17000 1 0 0.738 0.00675 3.81 PRS_PLINK_1.58489319246107e.102 TRUE 695.42 Systemic lupus erythematosus Both 3 9 13 dermatologic firebrick 9, 3 2, 0 2, 1 2, 2 2, 0 0.841 1.23 0.493 0.307 2.32 0.427 22 0.184 16800 1 0 1.2 0.0305 26.6 -0.886 180 0.996 0.002 0.412 0.000991 402 PRS_PLINK_1.58489319246107e.102 TRUE 695.7 Prurigo and Lichen Both 3 3 13 dermatologic firebrick 3, 3 1, 0 1, 0 1, 3 1, 0 0.0139 40.2 1 0 1.01 0.977 1.61 0.275 2330 1 0 1.32 0.736 1.68 PRS_PLINK_1.58489319246107e.102 TRUE 695.8 Other specified erythematous conditions Both 4 7 13 dermatologic firebrick 7, 4 1, 1 2, 0 1, 1 2, 2 1.53 1.63 0.349 0.457 4.61 0.507 82.8 0.107 12600 1 0 1.11 0.435 3.2 -0.0308 4060 1 0 0.97 0.909 1.1 0.0806 940 1 0 1.08 0.724 1.78 PRS_PLINK_1.58489319246107e.102 TRUE 695.9 Unspecified erythematous condition Both 0 8 13 dermatologic firebrick 8, 0 2 2 2 2 PRS_PLINK_1.58489319246107e.102 TRUE 696 Psoriasis and related disorders Both 4 9 13 dermatologic firebrick 9, 4 3, 2 2, 1 2, 0 2, 1 -0.772 1.37 0.574 0.241 0.462 0.0237 3.33 -0.799 433 0.999 0.001 0.45 0.932 191 -0.98 15900000 1 0 0.375 5.79e-07 33900 -0.164 157 0.999 0 0.849 0.342 1.46 PRS_PLINK_1.58489319246107e.102 TRUE 696.3 Pityriasis Both 1 3 13 dermatologic firebrick 3, 1 1, 0 1, 0 1, 1 1, 0 1.34 1920 0.999 0 3.83 0.00468 7510 -0.0131 36.6 1 0 0.987 0.822 1.63 PRS_PLINK_1.58489319246107e.102 TRUE 696.4 Psoriasis Both 3 10 13 dermatologic firebrick 10, 3 3, 2 2, 1 2, 0 3, 0 -0.655 1.85 0.723 0.141 0.519 0.0113 8.15 -0.0121 19.5 1 0 0.988 0.844 1.08 -0.0136 53.4 1 0 0.987 0.447 1.23 -0.0256 39.2 0.999 0 0.975 0.717 1.16 PRS_PLINK_1.58489319246107e.102 TRUE 696.41 Psoriasis vulgaris Both 3 8 13 dermatologic firebrick 8, 3 2, 2 2, 1 2, 0 2, 0 0.624 3.48 0.858 0.067 1.87 0.0104 2.09 -0.307 1210 1 0 0.736 0.000561 11100 -1.32 78.8 0.987 0.006 0.266 0.000102 982 -0.122 197 1 0 0.886 0.647 1.3 PRS_PLINK_1.58489319246107e.102 TRUE 696.42 Psoriatic arthropathy Both 1 2 13 dermatologic firebrick 2, 1 1, 0 1, 1 1, 0 1, 1 0.00653 153 1 0 1.01 0.782 1.3 -0.00741 59.5 1 0 0.993 0.92 1.25 PRS_PLINK_1.58489319246107e.102 TRUE 697 Sarcoidosis Both 0 4 13 dermatologic firebrick 4, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 698 Pruritus and related conditions Both 3 33 13 dermatologic firebrick 33, 3 9, 0 8, 1 8, 0 8, 2 0.641 0.854 0.453 0.344 1.9 0.33 37.5 0.996 1.53 0.516 0.287 2.71 0.216 5950 -0.134 2.25 0.952 0.021 0.874 0.000922 299 PRS_PLINK_1.58489319246107e.102 TRUE 700 Corns and callosities Both 10 20 13 dermatologic firebrick 20, 10 5, 1 5, 2 5, 2 5, 4 0.305 0.658 0.643 0.192 1.36 0.437 4.72 0.482 2.16 0.823 0.084 1.62 0.0799 3.05e+08 0.0991 3.48 0.977 0.01 1.1 0.00334 4400 -1.5 2.82 0.595 0.225 0.224 0.00153 5240 PRS_PLINK_1.58489319246107e.102 TRUE 701 Other hypertrophic and atrophic conditions of skin Both 9 47 13 dermatologic firebrick 47, 9 12, 1 12, 3 11, 2 12, 3 0.667 0.489 0.173 0.762 1.95 0.783 6.29 0.942 1.13 0.404 0.394 2.56 0.358 64.8 0.468 1.68 0.78 0.108 1.6 0.0238 1040 0.809 1.53 0.596 0.224 2.24 0.0263 87800 PRS_PLINK_1.58489319246107e.102 TRUE 701.1 Keratoderma, acquired Both 2 8 13 dermatologic firebrick 8, 2 2, 0 2, 0 2, 2 2, 0 0.377 1.99 0.85 0.071 1.46 0.0412 26.1 6.28 2990 0.998 0.001 534 0.158 4.7e+09 PRS_PLINK_1.58489319246107e.102 TRUE 701.2 Scar conditions and fibrosis of skin Both 1 24 13 dermatologic firebrick 24, 1 6, 1 6, 0 6, 0 6, 0 0.0748 0.803 0.926 0.033 1.08 0.154 14.6 0.612 2.58 0.812 0.09 1.84 0.000944 538 -0.313 2.88 0.913 0.039 0.731 0.00552 3210 0.345 3.26 0.916 0.038 1.41 0.00697 9040 PRS_PLINK_1.58489319246107e.102 TRUE 701.3 Circumscribed scleroderma Both 1 8 13 dermatologic firebrick 8, 1 2, 0 2, 1 2, 0 2, 0 -0.08 49600000 1 0 0.923 0.0149 3.48 -0.0351 1070 1 0 0.966 0.687 1.32 PRS_PLINK_1.58489319246107e.102 TRUE 701.4 Keloid scar Both 0 5 13 dermatologic firebrick 5, 0 2 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 701.5 Abnormal granulation tissue Both 0 4 13 dermatologic firebrick 4, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 702 Degenerative skin conditions and other dermatoses Both 11 31 13 dermatologic firebrick 31, 11 8, 3 8, 2 7, 4 8, 2 0.437 0.73 0.55 0.26 1.55 0.387 101 0.0281 1.33 0.983 0.007 1.03 0.00412 41.8 0.762 1.71 0.656 0.183 2.14 0.0665 1300 0.756 1.43 0.598 0.223 2.13 0.0892 76500 PRS_PLINK_1.58489319246107e.102 TRUE 702.1 Actinic keratosis Both 3 28 13 dermatologic firebrick 28, 3 6, 1 7, 0 7, 2 7, 0 -0.38 0.623 0.543 0.265 0.684 0.142 7.61 -0.524 1.6 0.743 0.129 0.592 0.0167 14.7 0.133 1.98 0.946 0.024 1.14 0.00267 45.1 0.243 3.55 0.946 0.024 1.27 0.000818 2000 PRS_PLINK_1.58489319246107e.102 TRUE 702.2 Seborrheic keratosis Both 9 32 13 dermatologic firebrick 32, 9 7, 3 8, 2 8, 3 8, 1 0.0664 0.59 0.91 0.041 1.07 0.208 5.13 -0.684 1.53 0.656 0.183 0.505 0.00624 36.9 1.03 1.59 0.517 0.286 2.8 0.116 625 -0.0911 1.98 0.963 0.016 0.913 0.000171 53500 PRS_PLINK_1.58489319246107e.102 TRUE 702.4 Degenerative skin disorders Both 0 1 13 dermatologic firebrick 1, 0 PRS_PLINK_1.58489319246107e.102 TRUE 703 Diseases of nail, NOS Both 8 20 13 dermatologic firebrick 20, 8 5, 2 5, 1 5, 2 5, 3 -0.0551 0.638 0.931 0.031 0.946 0.0544 3.1 0.0266 2.27 0.991 0.004 1.03 0.0159 35.4 0.995 2.53 0.694 0.159 2.7 0.00121 654 -0.221 1.45 0.879 0.056 0.802 0.0442 157 PRS_PLINK_1.58489319246107e.102 TRUE 703.1 Ingrowing nail Both 5 18 13 dermatologic firebrick 18, 5 5, 1 4, 2 4, 1 5, 1 -0.781 0.839 0.352 0.453 0.458 0.0239 1.88 -0.0473 1.83 0.979 0.009 0.954 0.0317 33.5 -1.57 3.5 0.655 0.184 0.209 0.167 32.6 -0.972 2.05 0.635 0.197 0.378 0.000923 10.3 PRS_PLINK_1.58489319246107e.102 TRUE 704 Diseases of hair and hair follicles Both 9 40 13 dermatologic firebrick 40, 9 9, 0 10, 2 10, 2 10, 5 1.14 0.544 0.0356 1.448 3.13 1.19 11.7 0.889 1.47 0.544 0.264 2.43 0.0759 2070 1.12 1.64 0.494 0.307 3.07 0.109 2480 1.89 1.63 0.246 0.61 6.62 0.196 5410 PRS_PLINK_1.58489319246107e.102 TRUE 704.1 Alopecia Both 2 17 13 dermatologic firebrick 17, 2 5, 0 4, 0 4, 1 4, 1 0.784 1.37 0.567 0.247 2.19 0.0263 48 0.441 5.43 0.935 0.029 1.55 0.000107 1380 -7.09 22.7 0.755 0.122 0.000834 0.000504 0.00141 PRS_PLINK_1.58489319246107e.102 TRUE 704.11 Alopecia Areata Both 1 2 13 dermatologic firebrick 2, 1 1, 0 0, 1 1, 0 1, 0 -0.00945 84.9 1 0 0.991 0.919 1.14 -0.00315 37.8 1 0 0.997 0.951 1.17 PRS_PLINK_1.58489319246107e.102 TRUE 704.2 Hirsutism Both 3 3 13 dermatologic firebrick 3, 3 1, 0 1, 0 0, 1 1, 2 15.8 1530 0.992 0.004 7330000 1.17e-16 7.49e+31 -0.00551 26.2 1 0 0.995 0.854 1.12 0.124 41900 1 0 1.13 0.00343 141 PRS_PLINK_1.58489319246107e.102 TRUE 704.8 Other specified diseases of hair and hair follicles Both 7 24 13 dermatologic firebrick 24, 7 5, 0 6, 1 6, 2 6, 4 0.93 0.573 0.105 0.981 2.53 1.02 14.9 1.01 88.7 0.991 0.004 2.75 2.24 7.25 2.4 4.67 0.607 0.217 11 0.0154 35900000 0.68 1.86 0.714 0.146 1.97 0.05 155 PRS_PLINK_1.58489319246107e.102 TRUE 705 Disorders of sweat glands Both 1 7 13 dermatologic firebrick 7, 1 2, 1 2, 0 1, 0 2, 0 -0.826 5020000 1 0 0.438 0.016 9.97 0.0463 1020 1 0 1.05 0.435 1.15 -0.393 3580 1 0 0.675 4.35e-07 151 0.21 2030 1 0 1.23 0.639 1.38 PRS_PLINK_1.58489319246107e.102 TRUE 705.1 Dyshidrosis Both 0 1 13 dermatologic firebrick 1, 0 PRS_PLINK_1.58489319246107e.102 TRUE 705.3 Hidradenitis Both 0 5 13 dermatologic firebrick 5, 0 2 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 705.8 Hyperhidrosis Both 3 15 13 dermatologic firebrick 15, 3 4, 1 4, 0 3, 0 4, 2 0.311 1.08 0.774 0.111 1.37 0.0677 137 -1.03 421 0.998 0.001 0.359 0.0436 0.232 0.346 40200000 1 0 1.41 1.95e-09 7e+07 -0.668 3.45 0.847 0.072 0.513 0.485 0.551 PRS_PLINK_1.58489319246107e.102 TRUE 706 Diseases of sebaceous glands Both 19 43 13 dermatologic firebrick 43, 19 11, 4 11, 2 10, 3 11, 9 0.356 0.344 0.3 0.522 1.43 0.769 2.86 -0.511 1.03 0.621 0.207 0.6 0.0777 3.69 1.25 1.51 0.41 0.387 3.48 0.233 202 0.435 0.886 0.624 0.205 1.54 0.321 7.95 PRS_PLINK_1.58489319246107e.102 TRUE 706.1 Acne Both 6 32 13 dermatologic firebrick 32, 6 8, 2 8, 1 8, 0 8, 3 0.494 0.485 0.308 0.512 1.64 0.716 4.96 0.545 1.81 0.763 0.117 1.73 0.0854 1910 0.35 2 0.861 0.065 1.42 0.0198 102 0.613 1.33 0.644 0.191 1.85 0.182 43.9 PRS_PLINK_1.58489319246107e.102 TRUE 706.2 Sebaceous cyst Both 9 29 13 dermatologic firebrick 29, 9 8, 2 7, 2 7, 0 7, 5 1.01 0.726 0.164 0.785 2.75 0.774 19.4 0.54 1.52 0.723 0.141 1.72 0.088 201 -0.181 2.12 0.932 0.031 0.834 0.00785 41.5 2.29 1.72 0.184 0.736 9.84 0.722 1070000 PRS_PLINK_1.58489319246107e.102 TRUE 706.3 Seborrhea Both 0 1 13 dermatologic firebrick 1, 0 PRS_PLINK_1.58489319246107e.102 TRUE 706.8 Other specified diseases of sebaceous glands Both 9 18 13 dermatologic firebrick 18, 9 5, 2 4, 0 4, 2 5, 4 0.375 0.726 0.606 0.218 1.45 0.406 9.37 -5.77e-13 6.07 1 0 1 0.000257 3930 -1.46 3.99 0.714 0.146 0.232 0.000196 91.2 1.56 2.38 0.512 0.291 4.77 0.109 549 PRS_PLINK_1.58489319246107e.102 TRUE 707 Chronic ulcer of skin Both 7 35 13 dermatologic firebrick 35, 7 8, 2 9, 2 8, 3 9, 0 0.317 0.486 0.514 0.289 1.37 0.58 3.62 0.402 1.26 0.75 0.125 1.49 0.134 573 3.1 2.07 0.135 0.868 22.1 0.568 136000 -0.874 1.65 0.596 0.224 0.417 0.00358 6.28 PRS_PLINK_1.58489319246107e.102 TRUE 707.1 Decubitus ulcer Both 2 14 13 dermatologic firebrick 14, 2 4, 1 3, 0 3, 1 4, 0 -1.26 2.09 0.547 0.262 0.284 0.000701 33.1 0.326 4410 1 0 1.38 0.0773 30.2 0.46 25500000 1 0 1.58 0.00476 22.2 2.21e-13 8.54 1 0 1 0.239 1.02 PRS_PLINK_1.58489319246107e.102 TRUE 707.2 Chronic ulcer of leg or foot Both 4 21 13 dermatologic firebrick 21, 4 6, 0 5, 2 5, 1 5, 1 0.57 0.711 0.423 0.373 1.77 0.459 8.44 1.66 1.73 0.336 0.473 5.27 0.408 305 1.01 3.2 0.753 0.123 2.73 0.0106 22200 1.31 4.37 0.765 0.116 3.69 2.12e-05 1610000 PRS_PLINK_1.58489319246107e.102 TRUE 707.3 Chronic ulcer of unspecified site Both 2 21 13 dermatologic firebrick 21, 2 6, 1 5, 0 5, 1 5, 0 0.228 1.04 0.826 0.083 1.26 0.0691 51.7 1.92 3.49 0.583 0.235 6.81 0.0407 15600 0.934 2.83 0.741 0.13 2.54 0.00134 696 1.17 3.85 0.762 0.118 3.21 0.000819 82700 PRS_PLINK_1.58489319246107e.102 TRUE 709 Diffuse diseases of connective tissue Both 5 18 13 dermatologic firebrick 18, 5 4, 2 4, 0 4, 1 5, 2 0.0182 0.619 0.977 0.01 1.02 0.339 3.46 -0.279 3.34 0.933 0.03 0.757 0.00444 143 1.59 2.73 0.561 0.251 4.88 0.0574 613 -0.801 3.02 0.791 0.102 0.449 0.000287 309 PRS_PLINK_1.58489319246107e.102 TRUE 709.2 Sicca syndrome Both 3 7 13 dermatologic firebrick 7, 3 1, 0 2, 2 1, 0 2, 1 -0.15 4.45 0.973 0.012 0.86 0.545 0.684 -1.25 679000 1 0 0.287 8.45e-07 2.51e+11 -0.00425 184 1 0 0.996 0.913 1.1 PRS_PLINK_1.58489319246107e.102 TRUE 709.7 Unspecified diffuse connective tissue disease Both 3 14 13 dermatologic firebrick 14, 3 4, 1 3, 1 3, 1 4, 0 0.234 1.46 0.872 0.059 1.26 0.119 98.2 0.0782 172 1 0 1.08 0.617 5.86 -0.855 10.1 0.932 0.03 0.425 0.314 0.555 -0.268 92.1 0.998 0.001 0.765 2.49e-07 2350000 PRS_PLINK_1.58489319246107e.102 TRUE 710 Osteomyelitis, periostitis, and other infections involving bone Both 2 17 14 musculoskeletal darkolivegreen 17, 2 5, 0 4, 0 4, 0 4, 1 -0.91 1.05 0.388 0.411 0.403 0.0378 9.62 0.763 2.46 0.756 0.121 2.15 0.0449 73.2 PRS_PLINK_1.58489319246107e.102 TRUE 710.1 Osteomyelitis Both 2 18 14 musculoskeletal darkolivegreen 18, 2 5, 0 4, 0 4, 0 5, 1 -0.961 1.07 0.37 0.432 0.383 0.0296 10.7 0.275 3.05 0.928 0.032 1.32 0.00246 170 PRS_PLINK_1.58489319246107e.102 TRUE 710.11 Acute osteomyelitis Both 0 8 14 musculoskeletal darkolivegreen 8, 0 2 2 2 2 PRS_PLINK_1.58489319246107e.102 TRUE 710.12 Chronic osteomyelitis Both 0 10 14 musculoskeletal darkolivegreen 10, 0 3 2 2 3 PRS_PLINK_1.58489319246107e.102 TRUE 710.19 Unspecified osteomyelitis Both 2 18 14 musculoskeletal darkolivegreen 18, 2 5, 0 4, 0 4, 0 5, 1 -1.16 1.1 0.29 0.537 0.314 0.00992 13 0.933 3.14 0.766 0.116 2.54 0.0103 235 PRS_PLINK_1.58489319246107e.102 TRUE 711 Arthropathy associated with infections Both 0 6 14 musculoskeletal darkolivegreen 6, 0 2 1 1 2 PRS_PLINK_1.58489319246107e.102 TRUE 711.1 Pyogenic arthritis Both 0 2 14 musculoskeletal darkolivegreen 2, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 712 Infective connective tissue disorders Both 0 1 14 musculoskeletal darkolivegreen 1, 0 PRS_PLINK_1.58489319246107e.102 TRUE 713 Arthropathy associated with other disorders classified elsewhere Both 3 9 14 musculoskeletal darkolivegreen 9, 3 3, 0 2, 1 2, 0 2, 1 -0.107 60.2 0.999 0.001 0.898 0.72 0.721 -0.058 479 1 0 0.944 0.553 1.44 -0.207 905 1 0 0.813 0.176 4.35 PRS_PLINK_1.58489319246107e.102 TRUE 713.5 Arthropathy associated with neurological disorders Both 3 6 14 musculoskeletal darkolivegreen 6, 3 2, 0 1, 1 1, 0 2, 1 -0.0465 300 1 0 0.955 0.694 1.2 -0.0581 389 1 0 0.944 0.539 1.55 0.132 4130 1 0 1.14 0.472 1.18 PRS_PLINK_1.58489319246107e.102 TRUE 714 Rheumatoid arthritis and other inflammatory polyarthropathies Both 4 19 14 musculoskeletal darkolivegreen 19, 4 5, 1 5, 0 4, 3 5, 0 -0.0686 0.98 0.944 0.025 0.934 0.0959 10.7 0.0372 5.26 0.994 0.002 1.04 0.000153 3030 -2.21 3.66 0.545 0.263 0.109 0.000208 21.6 -0.345 2.16 0.873 0.059 0.708 0.0186 20.6 PRS_PLINK_1.58489319246107e.102 TRUE 714.1 Rheumatoid arthritis Both 1 13 14 musculoskeletal darkolivegreen 13, 1 4, 1 3, 0 3, 0 3, 0 -0.389 1.01 0.701 0.154 0.678 0.0551 35.7 -0.156 3830 1 0 0.856 0.155 1.53 0.243 5120000 1 0 1.27 0.441 5.2 -0.278 2980000 1 0 0.758 0.185 6.3 PRS_PLINK_1.58489319246107e.102 TRUE 714.2 Juvenile rheumatoid arthritis Both 0 2 14 musculoskeletal darkolivegreen 2, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 715 Other inflammatory spondylopathies Both 4 8 14 musculoskeletal darkolivegreen 8, 4 2, 1 2, 0 2, 1 2, 2 3.48 3.43 0.311 0.507 32.4 0.453 8320000 -0.0865 5910 1 0 0.917 0.201 1.58 -4.05 1030 0.997 0.001 0.0174 4.96e-14 2.05e+10 -0.062 256 1 0 0.94 0.584 1.88 PRS_PLINK_1.58489319246107e.102 TRUE 715.1 Sacroiliitis NEC Both 2 1 14 musculoskeletal darkolivegreen 1, 2 -0.143 12600 1 0 0.867 0.554 1.3 PRS_PLINK_1.58489319246107e.102 TRUE 715.2 Ankylosing spondylitis Both 1 3 14 musculoskeletal darkolivegreen 3, 1 1, 0 1, 0 1, 1 1, 0 -0.0492 1160 1 0 0.952 0.428 1.39 -0.509 25100 1 0 0.601 0.00651 5.02 PRS_PLINK_1.58489319246107e.102 TRUE 716 Other arthropathies Both 18 42 14 musculoskeletal darkolivegreen 42, 18 11, 2 10, 1 10, 9 11, 5 0.407 0.361 0.259 0.586 1.5 0.78 3.15 -1.34 1.57 0.392 0.406 0.261 0.00372 5.2 4.21 1.89 0.0258 1.588 67.6 3.42 328000 1.24 1.5 0.41 0.387 3.45 0.216 2180 PRS_PLINK_1.58489319246107e.102 TRUE 716.1 Unspecified polyarthropathy or polyarthritis Both 1 0 14 musculoskeletal darkolivegreen 0, 1 PRS_PLINK_1.58489319246107e.102 TRUE 716.9 Arthropathy NOS Both 18 42 14 musculoskeletal darkolivegreen 42, 18 11, 2 10, 1 10, 9 11, 5 0.407 0.361 0.259 0.586 1.5 0.78 3.15 -1.34 1.57 0.392 0.406 0.261 0.00372 5.2 4.21 1.89 0.0258 1.588 67.6 3.42 328000 1.24 1.5 0.41 0.387 3.45 0.216 2180 PRS_PLINK_1.58489319246107e.102 TRUE 717 Polymyalgia Rheumatica Both 1 3 14 musculoskeletal darkolivegreen 3, 1 1, 0 1, 0 1, 1 1, 0 0.577 24400 1 0 1.78 0.235 152 -0.0034 75.6 1 0 0.997 0.95 1.04 PRS_PLINK_1.58489319246107e.102 TRUE 720 Spinal stenosis Both 1 28 14 musculoskeletal darkolivegreen 28, 1 6, 0 7, 1 7, 0 7, 0 -0.118 0.552 0.831 0.081 0.889 0.176 4.35 0.661 1.84 0.719 0.143 1.94 0.106 531 PRS_PLINK_1.58489319246107e.102 TRUE 720.1 Spinal stenosis of lumbar region Both 0 24 14 musculoskeletal darkolivegreen 24, 0 5 6 6 6 PRS_PLINK_1.58489319246107e.102 TRUE 721 Spondylosis and allied disorders Both 8 42 14 musculoskeletal darkolivegreen 42, 8 10, 1 10, 1 10, 3 11, 3 1.25 0.722 0.0833 1.079 3.49 0.937 32.8 0.267 1.54 0.862 0.064 1.31 0.0333 197 1 2.01 0.618 0.209 2.73 0.0626 9.6e+07 1.75 1.41 0.214 0.67 5.76 0.596 455 PRS_PLINK_1.58489319246107e.102 TRUE 721.1 Spondylosis without myelopathy Both 7 41 14 musculoskeletal darkolivegreen 41, 7 10, 0 10, 2 10, 3 10, 2 0.945 0.694 0.174 0.76 2.57 0.667 19.2 0.783 1.67 0.638 0.195 2.19 0.0262 308 0.524 1.67 0.754 0.123 1.69 0.0355 404 1.46 1.43 0.305 0.515 4.32 0.417 460 PRS_PLINK_1.58489319246107e.102 TRUE 721.2 Spondylosis with myelopathy Both 0 6 14 musculoskeletal darkolivegreen 6, 0 2 1 1 2 PRS_PLINK_1.58489319246107e.102 TRUE 721.8 Other allied disorders of spine Both 1 4 14 musculoskeletal darkolivegreen 4, 1 1, 0 1, 0 1, 0 1, 1 0.0781 2600 1 0 1.08 0.647 1.36 0.0554 85.8 0.999 0 1.06 0.908 1.13 PRS_PLINK_1.58489319246107e.102 TRUE 722 Intervertebral disc disorders Both 4 48 14 musculoskeletal darkolivegreen 48, 4 11, 0 12, 0 12, 3 12, 1 0.738 0.703 0.294 0.532 2.09 0.281 28.1 0.657 1.33 0.621 0.207 1.93 0.0799 130 0.739 1.39 0.594 0.226 2.09 0.113 150 PRS_PLINK_1.58489319246107e.102 TRUE 722.1 Displacement of intervertebral disc Both 1 39 14 musculoskeletal darkolivegreen 39, 1 9, 0 10, 0 9, 1 10, 0 0.281 0.599 0.639 0.195 1.32 0.191 8.15 0.351 1.63 0.83 0.081 1.42 0.00761 142 PRS_PLINK_1.58489319246107e.102 TRUE 722.6 Degeneration of intervertebral disc Both 3 35 14 musculoskeletal darkolivegreen 35, 3 8, 0 9, 0 8, 2 9, 1 0.645 0.746 0.387 0.412 1.91 0.29 35.2 0.67 1.79 0.709 0.15 1.95 0.0289 252 0.486 1.69 0.773 0.112 1.63 0.0453 138 PRS_PLINK_1.58489319246107e.102 TRUE 722.7 Intervertebral disc disorder with myelopathy Both 0 6 14 musculoskeletal darkolivegreen 6, 0 2 1 1 2 PRS_PLINK_1.58489319246107e.102 TRUE 722.8 Postlaminectomy syndrome Both 1 9 14 musculoskeletal darkolivegreen 9, 1 2, 0 2, 0 2, 0 2, 1 -3.02 89.3 0.973 0.012 0.0488 0.0405 0.0588 -0.167 13600 1 0 0.846 0.0874 6.78 PRS_PLINK_1.58489319246107e.102 TRUE 722.9 Other and unspecified disc disorder Both 1 27 14 musculoskeletal darkolivegreen 27, 1 6, 0 7, 0 6, 1 7, 0 -0.195 0.674 0.772 0.112 0.823 0.066 10.8 0.437 2.83 0.877 0.057 1.55 0.000528 277 PRS_PLINK_1.58489319246107e.102 TRUE 723 Other disorders of cervical region Both 2 14 14 musculoskeletal darkolivegreen 14, 2 3, 0 3, 0 3, 1 4, 1 0.126 0.817 0.877 0.057 1.13 0.265 16.7 -0.0267 1070 1 0 0.974 0.196 8.61 0.0248 829 1 0 1.03 1.09 2.52 PRS_PLINK_1.58489319246107e.102 TRUE 723.1 Torticollis Both 0 6 14 musculoskeletal darkolivegreen 6, 0 2 1 1 2 PRS_PLINK_1.58489319246107e.102 TRUE 724 Other and unspecified disorders of back Both 4 40 14 musculoskeletal darkolivegreen 40, 4 9, 0 10, 0 10, 2 10, 2 0.877 0.655 0.181 0.742 2.4 0.66 33.7 0.398 1.44 0.782 0.107 1.49 0.0522 2070 0.905 1.25 0.471 0.327 2.47 0.296 2840 PRS_PLINK_1.58489319246107e.102 TRUE 724.1 Disorders of sacrum Both 3 31 14 musculoskeletal darkolivegreen 31, 3 7, 0 8, 0 7, 2 8, 1 0.417 0.655 0.524 0.28 1.52 0.41 14.6 0.832 1.7 0.625 0.204 2.3 0.0928 149 0.239 1.59 0.88 0.055 1.27 0.0525 42.6 PRS_PLINK_1.58489319246107e.102 TRUE 724.2 Disorders of coccyx Both 0 7 14 musculoskeletal darkolivegreen 7, 0 2 2 1 2 PRS_PLINK_1.58489319246107e.102 TRUE 724.8 Other symptoms referable to back Both 0 14 14 musculoskeletal darkolivegreen 14, 0 4 3 3 4 PRS_PLINK_1.58489319246107e.102 TRUE 724.9 Other unspecified back disorders Both 2 15 14 musculoskeletal darkolivegreen 15, 2 3, 0 4, 0 3, 1 4, 1 0.0708 1.22 0.954 0.021 1.07 0.111 2480 0.00962 686 1 0 1.01 0.837 2.11 1.46 945 0.999 0.001 4.3 1390 24000 PRS_PLINK_1.58489319246107e.102 TRUE 726 Peripheral enthesopathies and allied syndromes Both 23 23 14 musculoskeletal darkolivegreen 23, 23 6, 3 6, 4 5, 12 6, 4 0.358 0.399 0.37 0.432 1.43 0.682 3.15 0.586 1.49 0.693 0.159 1.8 0.0462 115 1.54 1.29 0.231 0.637 4.67 0.615 24300000 1.27 1.47 0.385 0.415 3.57 0.292 192 PRS_PLINK_1.58489319246107e.102 TRUE 726.1 Enthesopathy Both 18 23 14 musculoskeletal darkolivegreen 23, 18 6, 3 6, 2 5, 11 6, 2 0.181 0.436 0.677 0.169 1.2 0.525 2.9 0.256 1.46 0.861 0.065 1.29 0.0371 44 1.49 1.29 0.251 0.6 4.42 0.574 1.07e+08 0.366 1.59 0.818 0.087 1.44 0.072 41.9 PRS_PLINK_1.58489319246107e.102 TRUE 726.2 Synoviopathy Both 2 6 14 musculoskeletal darkolivegreen 6, 2 2, 1 1, 0 1, 0 2, 1 -0.102 569 1 0 0.903 0.32 2.27 -3.27 9.95e+09 1 0 0.0382 9.37e-44 2.24e+39 -0.995 1.95e+08 1 0 0.37 0.00126 119 -0.0728 4990 1 0 0.93 0.521 2.3 PRS_PLINK_1.58489319246107e.102 TRUE 726.3 Bursitis Both 5 10 14 musculoskeletal darkolivegreen 10, 5 3, 2 2, 2 2, 1 3, 0 -0.166 1.1 0.88 0.055 0.847 0.152 9.2 -1.07 575 0.999 0.001 0.344 0.00264 0.0727 -0.373 122 0.998 0.001 0.688 0.12 0.345 -0.585 297 0.998 0.001 0.557 0.0368 63.9 PRS_PLINK_1.58489319246107e.102 TRUE 726.4 Calcaneal spur; Exostosis NOS Both 4 8 14 musculoskeletal darkolivegreen 8, 4 2, 2 2, 0 2, 1 2, 1 -0.568 1.46 0.697 0.157 0.566 0.0247 6.51 0.303 3240 1 0 1.35 0.164 2.7 0.145 537 1 0 1.16 0.432 4.55 0.187 1280 1 0 1.21 0.514 2.78 PRS_PLINK_1.58489319246107e.102 TRUE 727 Other disorders of synovium, tendon, and bursa Both 25 22 14 musculoskeletal darkolivegreen 22, 25 6, 3 5, 5 5, 14 6, 3 0.16 0.375 0.67 0.174 1.17 0.574 2.37 0.728 1.52 0.631 0.2 2.07 0.11 24700 1.46 1.14 0.202 0.695 4.29 0.638 337 1.13 1.73 0.513 0.29 3.11 0.0996 172 PRS_PLINK_1.58489319246107e.102 TRUE 727.1 Synovitis and tenosynovitis Both 11 17 14 musculoskeletal darkolivegreen 17, 11 5, 2 4, 2 4, 5 4, 2 0.141 0.586 0.81 0.091 1.15 0.384 3.6 0.138 1.91 0.942 0.026 1.15 0.0164 83.9 1.31 1.98 0.508 0.294 3.71 0.139 2.25e+08 3.88 5.06 0.443 0.353 48.3 0.00387 648000 PRS_PLINK_1.58489319246107e.102 TRUE 727.2 Bursitis disorders Both 0 2 14 musculoskeletal darkolivegreen 2, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 727.4 Ganglion and cyst of synovium, tendon, and bursa Both 2 8 14 musculoskeletal darkolivegreen 8, 2 2, 0 2, 1 2, 1 2, 0 0.391 2.46 0.874 0.059 1.48 1.44 1.52 0.184 2660 1 0 1.2 0.591 1.24 2.32 3.19e+08 1 0 10.2 0.0736 2.72e+08 PRS_PLINK_1.58489319246107e.102 TRUE 727.5 Rupture of synovium Both 1 1 14 musculoskeletal darkolivegreen 1, 1 -0.0193 7.14 0.998 0.001 0.981 0.965 1.04 PRS_PLINK_1.58489319246107e.102 TRUE 727.6 Rupture of tendon, nontraumatic Both 8 12 14 musculoskeletal darkolivegreen 12, 8 3, 2 3, 1 3, 4 3, 1 -0.0313 0.681 0.963 0.016 0.969 0.196 3.58 -2.14 19 0.91 0.041 0.117 0.00559 0.0776 -0.525 3.84 0.891 0.05 0.591 7.06e-06 16200 -0.33 25.5 0.99 0.005 0.719 0.468 0.959 PRS_PLINK_1.58489319246107e.102 TRUE 727.7 Contracture of tendon (sheath) Both 0 4 14 musculoskeletal darkolivegreen 4, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 727.8 Plica syndrome Both 3 0 14 musculoskeletal darkolivegreen 0, 3 PRS_PLINK_1.58489319246107e.102 TRUE 728 Disorders of muscle, ligament, and fascia Both 9 20 14 musculoskeletal darkolivegreen 20, 9 5, 1 5, 2 5, 3 5, 3 0.47 0.671 0.484 0.316 1.6 0.465 8.75 0.0993 2.11 0.962 0.017 1.1 0.0123 92.5 0.547 1.79 0.76 0.119 1.73 0.093 2150 -1.06 3.63 0.771 0.113 0.347 0.000305 151 PRS_PLINK_1.58489319246107e.102 TRUE 728.2 Laxity of ligament or hypermobility syndrome Both 1 1 14 musculoskeletal darkolivegreen 1, 1 -3.04 149 0.984 0.007 0.0476 0.00159 31.3 PRS_PLINK_1.58489319246107e.102 TRUE 728.7 Fasciitis Both 11 14 14 musculoskeletal darkolivegreen 14, 11 4, 2 3, 2 3, 4 4, 2 0.312 0.631 0.621 0.207 1.37 0.416 14 0.165 2.48 0.947 0.024 1.18 0.0159 117 0.185 2.71 0.946 0.024 1.2 0.00589 6920 1.06 3.4 0.756 0.122 2.88 0.0243 1120 PRS_PLINK_1.58489319246107e.102 TRUE 728.71 Contracture of palmar fascia [Dupuytren's disease] Both 1 2 14 musculoskeletal darkolivegreen 2, 1 1, 0 1, 1 1, 0 1, 1 0.0463 574 1 0 1.05 0.0425 1.38 0.0387 75.3 1 0 1.04 0.843 1.06 PRS_PLINK_1.58489319246107e.102 TRUE 729 Other disorders of soft tissues Both 10 20 14 musculoskeletal darkolivegreen 20, 10 5, 2 5, 1 5, 6 5, 1 -0.0988 0.539 0.854 0.068 0.906 0.328 2.4 0.732 1.66 0.659 0.181 2.08 0.131 57.9 0.202 1.21 0.868 0.062 1.22 0.151 9.99 -0.334 2.99 0.911 0.04 0.716 0.00104 108 PRS_PLINK_1.58489319246107e.102 TRUE 729.7 Nontraumatic compartment syndrome Both 0 1 14 musculoskeletal darkolivegreen 1, 0 PRS_PLINK_1.58489319246107e.102 TRUE 731 Osteitis deformans and osteopathies associated with other disorders classified elsewhere Both 0 8 14 musculoskeletal darkolivegreen 8, 0 2 2 2 2 PRS_PLINK_1.58489319246107e.102 TRUE 732 Osteochondropathies Both 1 4 14 musculoskeletal darkolivegreen 4, 1 1, 0 1, 1 1, 0 1, 0 0.413 4770 1 0 1.51 0.0132 132 -0.0188 40.6 1 0 0.981 0.676 1.07 PRS_PLINK_1.58489319246107e.102 TRUE 732.1 Juvenile osteochondrosis Both 1 0 14 musculoskeletal darkolivegreen 0, 1 PRS_PLINK_1.58489319246107e.102 TRUE 732.7 Osteochondritis dissecans Both 0 2 14 musculoskeletal darkolivegreen 2, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 733 Other disorders of bone and cartilage Both 5 30 14 musculoskeletal darkolivegreen 30, 5 8, 3 7, 0 7, 2 8, 0 -0.719 0.647 0.266 0.575 0.487 0.0998 1.55 -1.53 1.77 0.388 0.411 0.217 0.000952 5.16 1.23 1.79 0.493 0.307 3.41 0.0967 3840 -1.42 1.64 0.388 0.411 0.242 0.00114 28.4 PRS_PLINK_1.58489319246107e.102 TRUE 733.2 Cyst of bone Both 0 2 14 musculoskeletal darkolivegreen 2, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 733.4 Aseptic necrosis of bone Both 1 5 14 musculoskeletal darkolivegreen 5, 1 2, 0 1, 0 1, 0 1, 1 0.0456 1190 1 0 1.05 0.841 1.57 0.021 4950 1 0 1.02 0.487 2.25 PRS_PLINK_1.58489319246107e.102 TRUE 733.6 Costochondritis Both 1 2 14 musculoskeletal darkolivegreen 2, 1 1, 0 0, 1 1, 0 1, 0 9.6 2.73e+09 1 0 14700 4.64e-18 9.82e+23 -0.00793 35.7 1 0 0.992 0.621 1.34 PRS_PLINK_1.58489319246107e.102 TRUE 733.8 Malunion and nonunion of fracture Both 0 12 14 musculoskeletal darkolivegreen 12, 0 3 3 3 3 PRS_PLINK_1.58489319246107e.102 TRUE 735 Acquired foot deformities Both 11 35 14 musculoskeletal darkolivegreen 35, 11 9, 2 9, 2 8, 2 9, 4 -0.452 0.433 0.297 0.527 0.637 0.278 1.37 0.406 1.24 0.742 0.129 1.5 0.124 23.8 1.14 2.17 0.6 0.222 3.13 0.00224 619 0.0205 1.31 0.988 0.005 1.02 0.0537 15.1 PRS_PLINK_1.58489319246107e.102 TRUE 735.1 Flat foot Both 2 14 14 musculoskeletal darkolivegreen 14, 2 4, 0 3, 0 3, 1 4, 1 -0.223 1.25 0.859 0.066 0.8 0.0211 16.4 0.0969 3640000 1 0 1.1 0.117 16.7 0.158 239 0.999 0 1.17 1.06 1.24 PRS_PLINK_1.58489319246107e.102 TRUE 735.2 Acquired toe deformities Both 3 25 14 musculoskeletal darkolivegreen 25, 3 7, 0 6, 0 6, 0 6, 2 -0.551 0.699 0.431 0.366 0.577 0.0407 1.93 -0.379 2.18 0.862 0.064 0.685 0.00256 109 PRS_PLINK_1.58489319246107e.102 TRUE 735.21 Hammer toe (acquired) Both 3 21 14 musculoskeletal darkolivegreen 21, 3 6, 0 5, 0 5, 0 5, 2 -0.388 0.645 0.548 0.261 0.679 0.0715 1.9 0.459 3.87 0.906 0.043 1.58 1.45e-05 645 PRS_PLINK_1.58489319246107e.102 TRUE 735.23 Hallux rigidus Both 0 8 14 musculoskeletal darkolivegreen 8, 0 2 2 2 2 PRS_PLINK_1.58489319246107e.102 TRUE 735.3 Hallux valgus (Bunion) Both 6 26 14 musculoskeletal darkolivegreen 26, 6 7, 3 6, 1 6, 1 7, 0 -0.745 0.625 0.234 0.631 0.475 0.0904 1.88 0.103 1.51 0.946 0.024 1.11 0.0171 145 -0.324 2.88 0.91 0.041 0.723 0.00217 2520 0.319 2.3 0.89 0.051 1.38 0.0123 97000 PRS_PLINK_1.58489319246107e.102 TRUE 736 Other acquired deformities of limbs Both 7 34 14 musculoskeletal darkolivegreen 34, 7 9, 3 8, 1 8, 2 9, 1 -0.553 0.639 0.387 0.412 0.575 0.103 2.07 -0.469 1.53 0.759 0.12 0.625 0.00412 16.7 -0.0628 2.59 0.981 0.009 0.939 0.00466 30200 -0.843 1.55 0.586 0.232 0.43 0.00217 7.91 PRS_PLINK_1.58489319246107e.102 TRUE 736.2 Acquired deformities of finger Both 1 5 14 musculoskeletal darkolivegreen 5, 1 2, 0 1, 0 1, 1 1, 0 -1.88 2210 0.999 0 0.153 5.17e-16 7.4e+14 -0.00292 45.5 1 0 0.997 0.963 1.04 PRS_PLINK_1.58489319246107e.102 TRUE 736.4 Genu valgum or varum (acquired) Both 0 1 14 musculoskeletal darkolivegreen 1, 0 PRS_PLINK_1.58489319246107e.102 TRUE 736.6 Unequal leg length (acquired) Both 0 6 14 musculoskeletal darkolivegreen 6, 0 2 1 1 2 PRS_PLINK_1.58489319246107e.102 TRUE 737 Curvature of spine Both 2 18 14 musculoskeletal darkolivegreen 18, 2 5, 1 4, 0 4, 1 5, 0 -0.854 0.967 0.378 0.423 0.426 0.0187 2.24 0.109 2.77 0.969 0.014 1.12 0.0114 73.9 2.63 2.89 0.363 0.44 13.9 0.235 1970 0.662 5.85 0.91 0.041 1.94 7.74e-05 22400 PRS_PLINK_1.58489319246107e.102 TRUE 737.1 Kyphosis (acquired) Both 1 7 14 musculoskeletal darkolivegreen 7, 1 2, 0 2, 0 1, 1 2, 0 0.0118 92.7 1 0 1.01 0.878 1.2 0.659 2680 1 0 1.93 0.291 7.93 PRS_PLINK_1.58489319246107e.102 TRUE 737.2 Lordosis (acquired) Both 0 1 14 musculoskeletal darkolivegreen 1, 0 PRS_PLINK_1.58489319246107e.102 TRUE 737.3 Kyphoscoliosis and scoliosis Both 1 13 14 musculoskeletal darkolivegreen 13, 1 4, 1 3, 0 3, 0 3, 0 -0.643 1.33 0.629 0.202 0.526 0.0175 15.1 0.0816 6.41 0.99 0.004 1.09 1.07 3.4 0.0114 475 1 0 1.01 0.00362 31.7 -0.221 425 1 0 0.802 0.146 3.49 PRS_PLINK_1.58489319246107e.102 TRUE 738 Other acquired musculoskeletal deformity Both 3 24 14 musculoskeletal darkolivegreen 24, 3 6, 2 6, 1 6, 0 6, 0 -1.01 0.891 0.255 0.593 0.363 0.00201 6.79 -2.16 2.74 0.43 0.366 0.115 5.4e-05 16.3 -1.23 1.93 0.525 0.28 0.294 0.00251 58.3 -0.952 1.76 0.589 0.23 0.386 0.00205 11.2 PRS_PLINK_1.58489319246107e.102 TRUE 738.4 Acquired spondylolisthesis Both 0 12 14 musculoskeletal darkolivegreen 12, 0 3 3 3 3 PRS_PLINK_1.58489319246107e.102 TRUE 739 Contracture of joint Both 2 10 14 musculoskeletal darkolivegreen 10, 2 3, 0 2, 1 2, 1 3, 0 -0.415 1.56 0.79 0.102 0.66 0.0171 11.6 0.0625 566 1 0 1.06 0.224 5.9 -0.289 2.8e+07 1 0 0.749 0.0385 29.4 PRS_PLINK_1.58489319246107e.102 TRUE 740 Osteoarthrosis Both 23 40 14 musculoskeletal darkolivegreen 40, 23 10, 4 10, 2 10, 13 10, 3 0.187 0.311 0.548 0.261 1.21 0.681 2.19 -1.5 1.46 0.302 0.52 0.222 0.000699 6.56 1.02 0.853 0.233 0.633 2.77 0.641 15 0.251 1.2 0.834 0.079 1.29 0.136 12.6 PRS_PLINK_1.58489319246107e.102 TRUE 740.1 Osteoarthritis; localized Both 12 30 14 musculoskeletal darkolivegreen 30, 12 8, 2 7, 1 7, 5 8, 4 0.314 0.446 0.482 0.317 1.37 0.624 3.46 -1.65 1.71 0.336 0.474 0.193 0.00254 2.82 1.22 1.5 0.415 0.382 3.39 0.226 748 4.39 2.75 0.11 0.957 80.9 1.24 26700000 PRS_PLINK_1.58489319246107e.102 TRUE 740.11 Osteoarthrosis, localized, primary Both 9 29 14 musculoskeletal darkolivegreen 29, 9 8, 1 7, 0 7, 4 7, 4 1.25 0.795 0.115 0.939 3.5 0.895 36.2 -1.04 2.52 0.679 0.168 0.352 0.000981 125 1.17 1.51 0.44 0.356 3.21 0.0269 5010 4.89 2.86 0.087 1.06 133 1.25 146000 PRS_PLINK_1.58489319246107e.102 TRUE 740.12 Osteoarthrosis, localized, secondary Both 1 3 14 musculoskeletal darkolivegreen 3, 1 1, 0 1, 0 0, 1 1, 0 0.00875 7620 1 0 1.01 0.132 1.54 -0.00356 90.6 1 0 0.996 0.936 1.16 PRS_PLINK_1.58489319246107e.102 TRUE 740.2 Osteoarthrosis, generalized Both 4 10 14 musculoskeletal darkolivegreen 10, 4 3, 1 2, 1 2, 0 3, 2 -0.0894 1.07 0.934 0.03 0.914 0.133 12.6 -0.604 7750 1 0 0.547 0.246 1.78 -0.332 3750 1 0 0.717 0.552 1.98 -0.233 8100000 1 0 0.792 0.000211 9 PRS_PLINK_1.58489319246107e.102 TRUE 740.3 Osteoarthrosis involving more than one site, but not specified as generalized Both 2 1 14 musculoskeletal darkolivegreen 1, 2 -0.5 7460 1 0 0.607 0.6 3.65 PRS_PLINK_1.58489319246107e.102 TRUE 740.9 Osteoarthrosis NOS Both 23 40 14 musculoskeletal darkolivegreen 40, 23 10, 4 10, 2 10, 13 10, 3 0.187 0.311 0.548 0.261 1.21 0.681 2.19 -1.5 1.46 0.302 0.52 0.222 0.000699 6.56 1.02 0.853 0.233 0.633 2.77 0.641 15 0.251 1.2 0.834 0.079 1.29 0.136 12.6 PRS_PLINK_1.58489319246107e.102 TRUE 741 Symptoms and disorders of the joints Both 15 46 14 musculoskeletal darkolivegreen 46, 15 11, 6 11, 0 11, 8 12, 1 -0.0781 0.312 0.802 0.096 0.925 0.521 1.66 -2.41 1.71 0.158 0.802 0.0898 0.000367 1.84 0.882 0.936 0.346 0.461 2.42 0.492 16.3 -0.738 1.27 0.561 0.251 0.478 0.0327 4.46 PRS_PLINK_1.58489319246107e.102 TRUE 741.1 Ankylosis of joint Both 1 3 14 musculoskeletal darkolivegreen 3, 1 1, 1 1, 0 1, 0 1, 1 -0.0152 1950 1 0 0.985 0.941 1.63 -0.0117 69.2 1 0 0.988 0.872 1.05 -0.0312 261 1 0 0.969 0.858 1.17 PRS_PLINK_1.58489319246107e.102 TRUE 741.2 Stiffness of joint Both 2 17 14 musculoskeletal darkolivegreen 17, 2 5, 1 4, 0 4, 1 4, 0 -0.973 1.23 0.428 0.368 0.378 0.00338 215 -1.14 56.4 0.984 0.007 0.32 1.45e-05 21600 -1.61 3.63 0.657 0.183 0.199 0.000242 27 -1.53 7.94 0.847 0.072 0.215 9.74e-07 10200 PRS_PLINK_1.58489319246107e.102 TRUE 741.3 Difficulty in walking Both 1 23 14 musculoskeletal darkolivegreen 23, 1 6, 1 6, 0 5, 0 6, 0 -0.265 0.867 0.76 0.119 0.768 0.0339 14.1 -0.82 5.13 0.873 0.059 0.44 1.09e-05 3140 -0.0915 3.3 0.978 0.01 0.913 0.00548 14300 0.29 3.91 0.941 0.026 1.34 0.00131 24300 PRS_PLINK_1.58489319246107e.102 TRUE 741.4 Joint effusions Both 9 32 14 musculoskeletal darkolivegreen 32, 9 8, 4 8, 0 8, 3 8, 2 0.197 0.468 0.675 0.171 1.22 0.506 3.01 -1.49 1.57 0.344 0.463 0.226 0.000277 8.19 5.41 3.78 0.153 0.817 223 0.673 328 3.43 2.66 0.197 0.705 30.9 0.531 125000 PRS_PLINK_1.58489319246107e.102 TRUE 741.5 Hemarthrosis Both 1 2 14 musculoskeletal darkolivegreen 2, 1 1, 1 1, 0 1, 1 1, 0 -0.00597 32.6 1 0 0.994 0.96 1.2 0.00441 37.8 1 0 1 0.955 1.05 PRS_PLINK_1.58489319246107e.102 TRUE 741.6 Villonodular synovitis Both 1 1 14 musculoskeletal darkolivegreen 1, 1 -0.00175 352 1 0 0.998 0.955 1.14 PRS_PLINK_1.58489319246107e.102 TRUE 742 Derangement of joint, non-traumatic Both 7 45 14 musculoskeletal darkolivegreen 45, 7 11, 1 11, 0 11, 3 11, 3 0.597 0.471 0.205 0.688 1.82 0.766 5.39 -0.309 1.34 0.817 0.088 0.734 0.0143 59 0.951 1.43 0.507 0.295 2.59 0.0037 139000 0.753 1.08 0.487 0.313 2.12 0.339 17.5 PRS_PLINK_1.58489319246107e.102 TRUE 742.1 Loose body in joint Both 1 3 14 musculoskeletal darkolivegreen 3, 1 1, 0 1, 0 1, 1 1, 0 -1.25 84800 1 0 0.287 6.15e-09 13300000 1.25 310000 1 0 3.49 7.5e-08 1.63e+08 PRS_PLINK_1.58489319246107e.102 TRUE 742.2 Pathological, developmental or recurrent dislocation Both 0 3 14 musculoskeletal darkolivegreen 3, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 742.8 Articular cartilage disorder Both 1 5 14 musculoskeletal darkolivegreen 5, 1 2, 1 1, 0 1, 0 1, 0 0.133 63 0.998 0.001 1.14 0.513 2.56 1.72 15000 1 0 5.58 0.0149 51.8 0.282 15100 1 0 1.33 0.418 3.09 0.11 1250 1 0 1.12 0.769 1.96 PRS_PLINK_1.58489319246107e.102 TRUE 742.9 Other derangement of joint Both 5 43 14 musculoskeletal darkolivegreen 43, 5 10, 0 11, 0 10, 2 11, 3 1.25 0.683 0.0671 1.173 3.49 0.968 26.8 0.173 1.51 0.909 0.041 1.19 0.0112 166 1.31 1.31 0.319 0.496 3.69 0.463 99.9 PRS_PLINK_1.58489319246107e.102 TRUE 743 Osteoporosis, osteopenia and pathological fracture Both 12 51 14 musculoskeletal darkolivegreen 51, 12 12, 3 13, 1 12, 6 13, 2 -0.0242 0.37 0.948 0.023 0.976 0.478 2.04 -0.753 1.17 0.521 0.283 0.471 0.0437 46.1 1.01 1.04 0.329 0.483 2.75 0.424 34.7 0.0179 1.17 0.988 0.005 1.02 0.114 27.3 PRS_PLINK_1.58489319246107e.102 TRUE 743.1 Osteoporosis Both 6 22 14 musculoskeletal darkolivegreen 22, 6 6, 0 5, 1 5, 4 6, 1 0.386 0.722 0.593 0.227 1.47 0.441 9.42 -0.735 2.97 0.805 0.094 0.48 0.00079 55.7 0.473 2.54 0.852 0.069 1.6 0.00757 773 -0.719 4.26 0.866 0.062 0.487 4.03e-07 1530 PRS_PLINK_1.58489319246107e.102 TRUE 743.11 Osteoporosis NOS Both 6 21 14 musculoskeletal darkolivegreen 21, 6 6, 0 5, 1 5, 4 5, 1 0.386 0.722 0.593 0.227 1.47 0.441 9.42 -0.735 2.97 0.805 0.094 0.48 0.00079 55.7 -0.151 2.25 0.946 0.024 0.86 0.00442 52 -0.657 5.18 0.899 0.046 0.519 4.02e-07 7150 PRS_PLINK_1.58489319246107e.102 TRUE 743.12 Senile osteoporosis Both 0 4 14 musculoskeletal darkolivegreen 4, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 743.13 Other specified osteoporosis Both 3 4 14 musculoskeletal darkolivegreen 4, 3 1, 1 1, 1 1, 1 1, 0 -0.163 160 0.999 0 0.85 0.142 6.66 -0.0629 25700 1 0 0.939 0.224 3.14 1.01 2.13e+08 1 0 2.75 0.00832 242 0.03 212 1 0 1.03 0.738 1.34 PRS_PLINK_1.58489319246107e.102 TRUE 743.2 Pathologic fracture Both 2 8 14 musculoskeletal darkolivegreen 8, 2 2, 0 2, 1 2, 1 2, 0 -0.279 1.91 0.884 0.053 0.757 0.0335 20 16.1 134000 1 0 10200000 4.13e-13 2.75e+29 -0.383 1930 1 0 0.682 0.00488 61.5 PRS_PLINK_1.58489319246107e.102 TRUE 743.21 Pathologic fracture of vertebrae Both 1 4 14 musculoskeletal darkolivegreen 4, 1 1, 0 1, 0 1, 0 1, 1 0.0108 2960 1 0 1.01 0.402 1.49 0.000387 10.7 1 0 1 0.957 1.05 PRS_PLINK_1.58489319246107e.102 TRUE 743.22 Pathologic fracture of femur Both 0 1 14 musculoskeletal darkolivegreen 1, 0 PRS_PLINK_1.58489319246107e.102 TRUE 743.4 Stress fracture Both 2 6 14 musculoskeletal darkolivegreen 6, 2 2, 1 1, 0 1, 0 2, 1 0.133 1170 1 0 1.14 0.712 2.17 -0.0264 3360 1 0 0.974 0.382 2.39 -0.0246 1870 1 0 0.976 0.426 2.17 0.151 4640 1 0 1.16 0.412 1.26 PRS_PLINK_1.58489319246107e.102 TRUE 743.9 Osteopenia or other disorder of bone and cartilage Both 9 46 14 musculoskeletal darkolivegreen 46, 9 11, 3 11, 0 11, 4 12, 2 -0.105 0.375 0.78 0.108 0.901 0.435 1.88 -1.85 1.68 0.273 0.564 0.158 0.000161 4.7 0.398 1.01 0.692 0.16 1.49 0.242 11.1 0.663 1.37 0.628 0.202 1.94 0.157 69.9 PRS_PLINK_1.58489319246107e.102 TRUE 745 Pain in joint Both 42 22 14 musculoskeletal darkolivegreen 22, 42 5, 12 5, 4 5, 20 6, 6 0.221 0.309 0.474 0.324 1.25 0.713 2.25 -1.23 1.17 0.294 0.531 0.293 0.0199 2.21 0.431 0.829 0.603 0.219 1.54 0.327 8.51 0.677 1.36 0.62 0.208 1.97 0.178 120 PRS_PLINK_1.58489319246107e.102 TRUE 747 Cardiac and circulatory congenital anomalies Both 3 23 15 congenital anomalies mediumspringgreen 23, 3 5, 0 6, 1 5, 1 6, 1 0.614 0.684 0.37 0.432 1.85 0.585 38.1 1.67 3.24 0.606 0.217 5.31 0.0376 5350 -0.464 2.85 0.871 0.06 0.629 0.000752 46.1 -1.48 7.89 0.851 0.07 0.228 0.205 0.254 PRS_PLINK_1.58489319246107e.102 TRUE 747.1 Cardiac congenital anomalies Both 3 17 15 congenital anomalies mediumspringgreen 17, 3 4, 0 4, 1 4, 1 4, 1 0.592 0.693 0.393 0.405 1.81 0.609 118 0.0918 5540000 1 0 1.1 0.137 10.5 -1.82 45.5 0.968 0.014 0.162 2.02e-05 0.187 -0.623 37.5 0.987 0.006 0.536 0.178 0.286 PRS_PLINK_1.58489319246107e.102 TRUE 747.11 Cardiac shunt/ heart septal defect Both 1 9 15 congenital anomalies mediumspringgreen 9, 1 3, 0 2, 0 2, 0 2, 1 -0.14 2.45 0.954 0.02 0.869 0.0111 43.5 -0.49 330 0.999 0.001 0.613 0.125 1.8 PRS_PLINK_1.58489319246107e.102 TRUE 747.12 Valvular heart disease/ heart chambers Both 2 4 15 congenital anomalies mediumspringgreen 4, 2 1, 0 1, 0 1, 1 1, 1 0.0913 412 1 0 1.1 0.634 1.71 0.405 4020 1 0 1.5 0.649 1.66 -0.00629 60.6 1 0 0.994 0.927 1.07 PRS_PLINK_1.58489319246107e.102 TRUE 747.13 Congenital anomalies of great vessels Both 0 3 15 congenital anomalies mediumspringgreen 3, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 747.2 Congenital anomalies of peripheral vascular system Both 0 7 15 congenital anomalies mediumspringgreen 7, 0 2 2 1 2 PRS_PLINK_1.58489319246107e.102 TRUE 748 Anomalies of respiratory system, congenital Both 0 3 15 congenital anomalies mediumspringgreen 3, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 749 Congenital anomalies of face and neck Both 2 12 15 congenital anomalies mediumspringgreen 12, 2 3, 1 3, 0 3, 1 3, 0 0.035 0.762 0.963 0.016 1.04 0.163 4.57 -0.01 1220 1 0 0.99 0.47 1.22 -0.159 373 1 0 0.853 0.205 1.48 0.253 598 1 0 1.29 2.47 4.33 PRS_PLINK_1.58489319246107e.102 TRUE 749.1 Cleft palate Both 0 2 15 congenital anomalies mediumspringgreen 2, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 749.2 Congenital anomalies of skull and face bones Both 0 2 15 congenital anomalies mediumspringgreen 2, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 750 Digestive congenital anomalies Both 2 13 15 congenital anomalies mediumspringgreen 13, 2 4, 0 3, 1 3, 0 3, 1 0.982 2.02 0.627 0.203 2.67 0.0618 6690 6.46 5400 0.999 0 638 0.000212 5.84e+08 -0.479 75.2 0.995 0.002 0.619 0.197 1.03 PRS_PLINK_1.58489319246107e.102 TRUE 750.1 Upper gastrointestinal congenital anomalies Both 0 4 15 congenital anomalies mediumspringgreen 4, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 750.11 Esophageal atresia/tracheoesophageal fistula Both 0 2 15 congenital anomalies mediumspringgreen 2, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 750.13 Congenital anomalies of mouth/tongue Both 0 2 15 congenital anomalies mediumspringgreen 2, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 750.14 Congenital anomalies of esophagus Both 0 1 15 congenital anomalies mediumspringgreen 1, 0 PRS_PLINK_1.58489319246107e.102 TRUE 750.2 Lower gastrointestinal congenital anomalies Both 2 11 15 congenital anomalies mediumspringgreen 11, 2 2, 0 3, 1 2, 0 3, 1 0.189 1.57 0.905 0.044 1.21 0.119 469 -0.206 2370 1 0 0.814 0.138 1.81 0.047 3310 1 0 1.05 0.575 2.04 PRS_PLINK_1.58489319246107e.102 TRUE 750.21 Congenital anomalies of intestine Both 1 6 15 congenital anomalies mediumspringgreen 6, 1 1, 1 1, 0 1, 0 2, 0 5.7 138 0.967 0.015 299 0.000364 3.54e+09 -0.00327 58.6 1 0 0.997 0.979 1.01 0.0147 352 1 0 1.01 0.929 1.05 -1.77 5890 1 0 0.17 5.22e-07 443 PRS_PLINK_1.58489319246107e.102 TRUE 750.22 Congenital anomaly of gallbladder, bile ducts, liver, pancreas Both 1 9 15 congenital anomalies mediumspringgreen 9, 1 2, 0 2, 0 2, 0 2, 1 0.0922 1.62 0.955 0.02 1.1 0.1 19.4 -0.0993 1280 1 0 0.905 0.516 1.18 PRS_PLINK_1.58489319246107e.102 TRUE 751 Genitourinary congenital anomalies Both 8 28 15 congenital anomalies mediumspringgreen 28, 8 6, 1 7, 3 7, 2 7, 2 0.334 0.516 0.517 0.286 1.4 0.578 4.45 0.926 1.32 0.484 0.315 2.53 0.313 41.4 2.04 2 0.308 0.511 7.66 0.287 1210 0.987 3.16 0.754 0.122 2.68 0.00144 5.18e+08 PRS_PLINK_1.58489319246107e.102 TRUE 751.1 Congenital anomalies of genital organs Both 3 5 15 congenital anomalies mediumspringgreen 5, 3 2, 1 1, 0 1, 0 1, 2 -0.112 332 1 0 0.894 0.132 4.52 -0.118 3900 1 0 0.888 0.0635 6.76 0.00175 88.6 1 0 1 0.94 1.08 -0.057 886 1 0 0.945 0.172 3.14 PRS_PLINK_1.58489319246107e.102 TRUE 751.11 Congenital anomalies of female genital organs Female 2 3 15 congenital anomalies mediumspringgreen 3, 2 1, 1 1, 0 1, 1 1, 1 0.00692 358 1 0 1.01 0.825 1.46 0.0633 1110 1 0 1.07 0.71 2.43 3.07e-05 2740 1 0 1 0.145 2.12 PRS_PLINK_1.58489319246107e.102 TRUE 751.12 Congenital anomalies of male genital organs Male 0 4 15 congenital anomalies mediumspringgreen 4, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 751.2 Congenital anomalies of urinary system Both 6 7 15 congenital anomalies mediumspringgreen 7, 6 1, 0 2, 3 1, 2 2, 1 -0.357 1.1 0.745 0.128 0.7 0.64 4.57 0.141 5440 1 0 1.15 0.24 11.4 -0.0629 2360 1 0 0.939 0.544 1.46 -0.998 93100 1 0 0.368 0.00662 38.4 PRS_PLINK_1.58489319246107e.102 TRUE 751.21 Cystic kidney disease Both 2 4 15 congenital anomalies mediumspringgreen 4, 2 1, 0 1, 1 1, 1 1, 0 -0.143 1030 1 0 0.867 0.363 11.4 -0.00243 103 1 0 0.998 0.955 1.05 -0.00515 61.2 1 0 0.995 0.876 1.02 PRS_PLINK_1.58489319246107e.102 TRUE 751.22 Other specified congenital anomalies of kidney Both 5 3 15 congenital anomalies mediumspringgreen 3, 5 1, 0 1, 0 1, 5 1, 0 -0.00349 318 1 0 0.997 0.42 1.06 0.00331 1330 1 0 1 0.209 1.49 PRS_PLINK_1.58489319246107e.102 TRUE 751.3 Obstructive genitourinary defect Both 1 4 15 congenital anomalies mediumspringgreen 4, 1 1, 0 1, 0 1, 0 1, 1 0.563 34900 1 0 1.76 0.0606 6630 0.00164 48.4 1 0 1 0.943 1.07 PRS_PLINK_1.58489319246107e.102 TRUE 752 Nervous system congenital anomalies Both 1 15 15 congenital anomalies mediumspringgreen 15, 1 4, 0 4, 0 3, 0 4, 1 1.46 1.97 0.46 0.337 4.3 0.245 24100 0.033 145 1 0 1.03 1.09 1.41 PRS_PLINK_1.58489319246107e.102 TRUE 752.1 Neural tube defects Both 0 13 15 congenital anomalies mediumspringgreen 13, 0 4 3 3 3 PRS_PLINK_1.58489319246107e.102 TRUE 752.11 Spina bifida Both 0 2 15 congenital anomalies mediumspringgreen 2, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 752.2 Other specified congenital anomalies of nervous system Both 0 4 15 congenital anomalies mediumspringgreen 4, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 753 Congenital anomalies of the eye Both 1 8 15 congenital anomalies mediumspringgreen 8, 1 2, 0 2, 0 2, 0 2, 1 0.627 23.3 0.979 0.009 1.87 1.02 5.33 0.0207 309 1 0 1.02 0.935 1.12 PRS_PLINK_1.58489319246107e.102 TRUE 753.1 Congenital cataract and lens anomalies Both 0 1 15 congenital anomalies mediumspringgreen 1, 0 PRS_PLINK_1.58489319246107e.102 TRUE 753.2 Congenital anomalies of posterior segment of eye Both 0 3 15 congenital anomalies mediumspringgreen 3, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 754 Congenital musculoskeletal deformities of spine Both 1 11 15 congenital anomalies mediumspringgreen 11, 1 3, 0 3, 0 2, 1 3, 0 0.114 1.39 0.935 0.029 1.12 0.132 102 0.0322 156 1 0 1.03 0.751 2.29 PRS_PLINK_1.58489319246107e.102 TRUE 754.1 Lumbosacral spondylolysis, congenital Both 1 2 15 congenital anomalies mediumspringgreen 2, 1 1, 0 1, 1 1, 0 1, 1 0.0355 536 1 0 1.04 0.825 1.24 -0.000734 48.9 1 0 0.999 0.981 1.02 PRS_PLINK_1.58489319246107e.102 TRUE 754.2 Spondylolisthesis, congenital Both 0 5 15 congenital anomalies mediumspringgreen 5, 0 2 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 755 Congenital anomalies of limbs Both 1 14 15 congenital anomalies mediumspringgreen 14, 1 4, 0 3, 0 3, 1 4, 0 -0.387 1.17 0.742 0.13 0.679 0.0414 18 0.2 127000 1 0 1.22 1.24 4.71 PRS_PLINK_1.58489319246107e.102 TRUE 755.1 Congenital deformities of feet Both 1 9 15 congenital anomalies mediumspringgreen 9, 1 3, 0 2, 0 2, 1 2, 0 4.32e-12 7.24 1 0 1 0.00153 533 -0.0623 1150 1 0 0.94 0.449 1.35 PRS_PLINK_1.58489319246107e.102 TRUE 755.6 Other congenital anomalies of lower limb, including pelvic girdle Both 0 4 15 congenital anomalies mediumspringgreen 4, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 755.61 Congenital hip dysplasia and deformity Both 0 2 15 congenital anomalies mediumspringgreen 2, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 756 Other congenital musculoskeletal anomalies Both 2 17 15 congenital anomalies mediumspringgreen 17, 2 4, 0 4, 0 4, 2 4, 0 0.157 0.587 0.789 0.103 1.17 0.231 5.57 -0.529 8.43 0.95 0.022 0.589 3.54e-05 23700 PRS_PLINK_1.58489319246107e.102 TRUE 756.2 Pectus and other congenital anomalies of ribs/sternum Both 0 1 15 congenital anomalies mediumspringgreen 1, 0 PRS_PLINK_1.58489319246107e.102 TRUE 756.3 Congenital anomalies of muscle, tendon, fascia, and connective tissue Both 0 2 15 congenital anomalies mediumspringgreen 2, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 756.5 Congenital osteodystrophies Both 1 11 15 congenital anomalies mediumspringgreen 11, 1 2, 0 3, 0 2, 1 3, 0 -0.0183 1.1 0.987 0.006 0.982 0.165 6.46 -0.27 4310 1 0 0.764 0.616 2.1 PRS_PLINK_1.58489319246107e.102 TRUE 757 Congenital anomalies of the integument Both 1 4 15 congenital anomalies mediumspringgreen 4, 1 1, 0 1, 0 1, 0 1, 0 0.0241 1550 1 0 1.02 8.49e-05 787 PRS_PLINK_1.58489319246107e.102 TRUE 758 Chromosomal anomalies and genetic disorders Both 1 2 15 congenital anomalies mediumspringgreen 2, 1 1, 0 0, 1 1, 0 1, 0 -0.0329 2060 1 0 0.968 0.702 1.23 -0.00268 55 1 0 0.997 0.878 1.06 PRS_PLINK_1.58489319246107e.102 TRUE 758.1 Chromosomal anomalies Both 1 0 15 congenital anomalies mediumspringgreen 0, 1 PRS_PLINK_1.58489319246107e.102 TRUE 759 Other and unspecified congenital anomalies Both 0 3 15 congenital anomalies mediumspringgreen 3, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 760 Back pain Both 25 39 17 symptoms purple 39, 25 9, 1 10, 6 9, 11 10, 7 0.535 0.314 0.0879 1.056 1.71 0.99 3.26 1.97 1.48 0.182 0.739 7.21 0.488 7960 2.27 1.27 0.0756 1.121 9.63 1.21 282 2.1 1.31 0.11 0.959 8.18 1.02 902 PRS_PLINK_1.58489319246107e.102 TRUE 761 Cervicalgia Both 15 48 17 symptoms purple 48, 15 11, 3 12, 2 12, 7 12, 3 0.526 0.395 0.183 0.737 1.69 0.822 4.05 0.185 1.1 0.867 0.062 1.2 0.122 12.5 1.8 1.18 0.127 0.895 6.05 0.833 183 1.68 1.6 0.294 0.532 5.36 0.351 8260 PRS_PLINK_1.58489319246107e.102 TRUE 763 Thoracic or lumbosacral neuritis or radiculitis, unspecified Both 2 39 17 symptoms purple 39, 2 9, 0 10, 0 9, 0 10, 2 0.69 0.625 0.269 0.57 1.99 0.576 39.8 1.08 1.42 0.444 0.353 2.96 0.252 9560 PRS_PLINK_1.58489319246107e.102 TRUE 764 Sciatica Both 2 38 17 symptoms purple 38, 2 9, 0 9, 0 9, 1 10, 1 0.621 0.686 0.366 0.437 1.86 0.462 103 0.655 1.73 0.704 0.152 1.93 0.0207 185 0.719 1.56 0.644 0.191 2.05 0.0239 633 PRS_PLINK_1.58489319246107e.102 TRUE 765 Cervical radiculitis Both 3 25 17 symptoms purple 25, 3 6, 1 6, 1 6, 1 6, 0 -0.257 0.521 0.622 0.206 0.774 0.0655 2.37 -0.425 2.47 0.863 0.064 0.654 0.00198 49.9 2.12 3 0.479 0.32 8.34 0.124 1970000 0.00498 1.58 0.997 0.001 1 0.0266 19.8 PRS_PLINK_1.58489319246107e.102 TRUE 766 Neuralgia, neuritis, and radiculitis NOS Both 6 48 17 symptoms purple 48, 6 11, 1 12, 1 12, 2 12, 2 0.316 0.431 0.464 0.333 1.37 0.588 3.61 0.201 1.14 0.86 0.065 1.22 0.101 30.6 0.595 1.15 0.606 0.218 1.81 0.223 45.3 0.811 1.19 0.495 0.305 2.25 0.258 4180 PRS_PLINK_1.58489319246107e.102 TRUE 767 Cervicocranial/Cervicobrachial syndrome Both 0 1 17 symptoms purple 1, 0 PRS_PLINK_1.58489319246107e.102 TRUE 769 Nonallopathic lesions NEC Both 2 20 17 symptoms purple 20, 2 5, 0 5, 0 5, 1 5, 1 -0.0219 0.617 0.972 0.012 0.978 0.179 4.33 -0.0413 3.01 0.989 0.005 0.96 0.007 185 -0.517 2.35 0.826 0.083 0.596 0.548 0.731 PRS_PLINK_1.58489319246107e.102 TRUE 770 Myalgia and myositis unspecified Both 11 47 17 symptoms purple 47, 11 11, 0 12, 4 11, 4 12, 3 0.321 0.404 0.428 0.369 1.38 0.65 3.3 0.681 1.38 0.62 0.207 1.98 0.0229 10900 3.87 2.44 0.113 0.948 47.8 0.796 11500000 0.883 1.24 0.476 0.322 2.42 0.296 102 PRS_PLINK_1.58489319246107e.102 TRUE 771 Musculoskeletal symptoms referable to limbs Both 6 44 17 symptoms purple 44, 6 10, 1 11, 1 11, 1 11, 3 0.049 0.542 0.928 0.032 1.05 0.3 4.28 -0.736 1.36 0.589 0.23 0.479 0.00297 5.78 -1.54 1.98 0.436 0.36 0.215 0.00135 45.5 0.291 1.65 0.86 0.066 1.34 0.003 653 PRS_PLINK_1.58489319246107e.102 TRUE 771.1 Swelling of limb Both 11 43 17 symptoms purple 43, 11 10, 3 11, 0 10, 2 11, 6 0.168 0.365 0.646 0.19 1.18 0.611 2.5 -1.87 1.45 0.197 0.706 0.154 6.49e-05 1.66 -2.26 1.61 0.159 0.798 0.104 3.75e-05 1.52 -0.109 1.16 0.925 0.034 0.897 0.0809 8.76 PRS_PLINK_1.58489319246107e.102 TRUE 771.2 Cramp of limb Both 1 18 17 symptoms purple 18, 1 5, 1 4, 0 4, 0 5, 0 -0.00637 1.03 0.995 0.002 0.994 0.115 27.6 -0.661 16 0.967 0.015 0.516 0.494 0.54 4.93 14.7 0.737 0.133 138 5.3e-06 2.36e+09 -0.475 6.08 0.938 0.028 0.622 5.29e-07 13400 PRS_PLINK_1.58489319246107e.102 TRUE 772 Symptoms of the muscles Both 6 23 17 symptoms purple 23, 6 5, 0 6, 1 5, 1 6, 4 0.431 0.734 0.557 0.254 1.54 0.312 11.3 -1.23 3.96 0.756 0.122 0.292 6.47e-05 89.4 -2.93 6.07 0.629 0.202 0.0533 2.72e-08 188 0.444 3.36 0.895 0.048 1.56 0.0037 339 PRS_PLINK_1.58489319246107e.102 TRUE 772.1 Muscular wasting and disuse atrophy Both 1 9 17 symptoms purple 9, 1 3, 1 2, 0 2, 0 2, 0 1.54 11.3 0.892 0.05 4.66 7.46e-07 2.84e+08 -0.578 2040 1 0 0.561 0.428 2.94 0.272 4740 1 0 1.31 0.553 8.36 -0.0676 267 1 0 0.935 0.000308 186 PRS_PLINK_1.58489319246107e.102 TRUE 772.2 Spasm of muscle Both 3 31 17 symptoms purple 31, 3 7, 0 8, 2 7, 0 8, 1 0.308 0.56 0.582 0.235 1.36 0.435 9.66 0.329 1.84 0.858 0.067 1.39 0.00598 40.7 0.335 1.34 0.803 0.095 1.4 0.143 32.4 PRS_PLINK_1.58489319246107e.102 TRUE 772.3 Muscle weakness Both 4 27 17 symptoms purple 27, 4 7, 0 7, 1 6, 2 7, 1 0.555 0.801 0.488 0.312 1.74 0.345 150 1.4 2.43 0.564 0.249 4.07 0.00154 1370 1.69 3.72 0.65 0.187 5.43 0.0107 14600 0.0972 1.9 0.959 0.018 1.1 0.00117 29.5 PRS_PLINK_1.58489319246107e.102 TRUE 772.4 Rhabdomyolysis Both 2 0 17 symptoms purple 0, 2 PRS_PLINK_1.58489319246107e.102 TRUE 772.6 Facial weakness Both 0 3 17 symptoms purple 3, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 780 Hypothermia/Chills Both 1 8 17 symptoms purple 8, 1 2, 0 2, 1 2, 0 2, 0 1.07 4.88 0.826 0.083 2.92 1.17 7.52 0.62 4770 1 0 1.86 0.46 1.91 PRS_PLINK_1.58489319246107e.102 TRUE 781 Symptoms involving nervous and musculoskeletal systems Both 4 31 17 symptoms purple 31, 4 8, 0 8, 0 7, 4 8, 0 0.242 1.18 0.838 0.077 1.27 0.0125 150 -0.112 2.15 0.958 0.018 0.894 0.00118 73.2 PRS_PLINK_1.58489319246107e.102 TRUE 782.3 Edema Both 12 40 17 symptoms purple 40, 12 9, 3 10, 1 10, 5 10, 3 0.045 0.359 0.9 0.046 1.05 0.532 2.12 -0.504 1.24 0.684 0.165 0.604 0.0108 11.3 0.0559 1.04 0.957 0.019 1.06 0.14 6.75 -0.165 1.23 0.893 0.049 0.848 0.0451 23.2 PRS_PLINK_1.58489319246107e.102 TRUE 782.6 Pallor and flushing Both 2 10 17 symptoms purple 10, 2 3, 1 2, 0 2, 0 3, 1 -0.426 3.03 0.888 0.052 0.653 0.000338 193 -0.223 2640 1 0 0.8 0.107 2.08 0.0921 1420 1 0 1.1 0.471 1.21 -0.196 887 1 0 0.822 0.213 3.4 PRS_PLINK_1.58489319246107e.102 TRUE 783 Fever of unknown origin Both 10 52 17 symptoms purple 52, 10 12, 2 13, 1 13, 3 13, 4 0.3 0.357 0.4 0.398 1.35 0.709 2.94 -0.386 1.28 0.763 0.117 0.68 0.0128 28.6 1.31 1.23 0.287 0.543 3.72 0.447 164 0.0562 1.06 0.958 0.019 1.06 0.125 7.89 PRS_PLINK_1.58489319246107e.102 TRUE 785 Abdominal pain Both 30 34 17 symptoms purple 34, 30 8, 7 8, 10 8, 9 9, 4 -0.0572 0.284 0.84 0.076 0.944 0.557 1.59 0.421 0.796 0.597 0.224 1.52 0.387 6.44 0.0605 0.858 0.944 0.025 1.06 0.227 4.9 -1.23 1.22 0.314 0.503 0.292 0.016 2.22 PRS_PLINK_1.58489319246107e.102 TRUE 788 Syncope and collapse Both 5 49 17 symptoms purple 49, 5 12, 1 12, 1 12, 3 12, 0 0.171 0.512 0.739 0.132 1.19 0.397 4.49 0.0062 1.2 0.996 0.002 1.01 0.0675 18.7 1.16 1.25 0.353 0.452 3.18 0.314 8300 0.0667 1.48 0.964 0.016 1.07 0.0317 4380 PRS_PLINK_1.58489319246107e.102 TRUE 789 Nausea and vomiting Both 18 46 17 symptoms purple 46, 18 11, 5 11, 2 11, 6 12, 5 0.173 0.299 0.564 0.249 1.19 0.693 2.13 -0.831 0.94 0.376 0.425 0.435 0.0556 2.19 0.0684 0.863 0.937 0.028 1.07 0.226 5.05 -0.343 0.98 0.726 0.139 0.709 0.0972 4.04 PRS_PLINK_1.58489319246107e.102 TRUE 789.1 Persistent vomiting Both 2 10 17 symptoms purple 10, 2 2, 0 2, 1 2, 0 3, 1 0.04 3.02 0.989 0.005 1.04 0.000221 196 0.731 5900 1 0 2.08 0.533 2.26 -1.12 2590 1 0 0.327 0.302 2.46 PRS_PLINK_1.58489319246107e.102 TRUE 790 Nonspecific findings on examination of blood Both 16 27 17 symptoms purple 27, 16 6, 2 7, 3 6, 2 7, 9 0.129 0.606 0.831 0.08 1.14 0.154 5.05 0.279 1.75 0.874 0.059 1.32 0.0139 55.4 -0.614 1.74 0.725 0.14 0.541 0.00642 67.2 1.32 1.97 0.502 0.299 3.75 0.0397 5460 PRS_PLINK_1.58489319246107e.102 TRUE 790.1 Elevated sedimentation rate Both 1 4 17 symptoms purple 4, 1 1, 0 1, 0 1, 0 1, 1 -0.229 7880 1 0 0.796 0.0277 2.24 -0.00324 35 1 0 0.997 0.95 1.05 PRS_PLINK_1.58489319246107e.102 TRUE 790.6 Other abnormal blood chemistry Both 22 40 17 symptoms purple 40, 22 9, 3 10, 4 10, 5 10, 10 0.503 0.352 0.153 0.814 1.65 0.893 3.48 0.576 1.36 0.672 0.173 1.78 0.101 109 -0.613 1.25 0.624 0.205 0.542 0.0309 5.19 0.151 1.19 0.898 0.047 1.16 0.0827 13.6 PRS_PLINK_1.58489319246107e.102 TRUE 790.8 Elevated C-reactive protein (CRP) Both 0 5 17 symptoms purple 5, 0 2 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 790.9 Abnormal arterial blood gases Both 0 2 17 symptoms purple 2, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 791 Gangrene Both 0 13 17 symptoms purple 13, 0 4 3 3 3 PRS_PLINK_1.58489319246107e.102 TRUE 792 Abnormal Papanicolaou smear of cervix and cervical HPV Female 6 15 11 genitourinary black 15, 6 3, 3 4, 1 3, 0 4, 2 -0.576 0.74 0.437 0.36 0.562 0.117 1.76 -1.73 3.3 0.601 0.221 0.178 0.000362 15.8 0.473 72.1 0.995 0.002 1.61 1.79e-05 16400 -2.52 3.09 0.416 0.381 0.0806 3.34e-05 5.23 PRS_PLINK_1.58489319246107e.102 TRUE 792.1 Papanicolaou smear of cervix or vagina with atypical squamous cells Female 4 7 11 genitourinary black 7, 4 1, 2 2, 0 1, 0 2, 2 1.26 1.4 0.369 0.432 3.51 0.523 36.8 0.0477 2130 1 0 1.05 5.81e-05 9860 5.49 5.97e+08 1 0 243 8.17e-07 7.05e+15 0.069 629 1 0 1.07 0.366 15.2 PRS_PLINK_1.58489319246107e.102 TRUE 794 Abnormal results of other function studies (bladder, pancreas, placenta, spleen, etc) Both 0 5 17 symptoms purple 5, 0 2 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 795 Other and nonspecific abnormal cytological, histological and immunological findings Both 3 27 17 symptoms purple 27, 3 6, 1 7, 1 6, 0 7, 1 -0.149 0.513 0.771 0.113 0.861 0.111 2.5 -0.0944 1.6 0.953 0.021 0.91 0.0061 15.2 0.525 3.71 0.887 0.052 1.69 0.00148 16300 0.125 2.38 0.958 0.019 1.13 0.0168 45.9 PRS_PLINK_1.58489319246107e.102 TRUE 795.8 Abnormal tumor markers Both 1 13 17 symptoms purple 13, 1 4, 0 3, 0 3, 0 3, 1 -0.823 1.93 0.669 0.174 0.439 0.00347 16.2 1.45 237 0.995 0.002 4.25 1.64 16.1 PRS_PLINK_1.58489319246107e.102 TRUE 795.81 Elevated carcinoembryonic antigen [CEA] Both 0 1 17 symptoms purple 1, 0 PRS_PLINK_1.58489319246107e.102 TRUE 795.82 Elevated cancer antigen 125 [CA 125] Both 0 2 17 symptoms purple 2, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 796 Elevated prostate specific antigen [PSA] Male 2 10 11 genitourinary black 10, 2 3, 0 2, 1 2, 0 3, 1 -0.637 2.4 0.791 0.102 0.529 0.0011 70.7 0.0666 1300 1 0 1.07 0.704 1.31 1.98 554 0.997 0.001 7.23 0.0683 826 PRS_PLINK_1.58489319246107e.102 TRUE 797 Shock Both 0 10 17 symptoms purple 10, 0 3 2 2 3 PRS_PLINK_1.58489319246107e.102 TRUE 797.1 Cardiogenic shock Both 0 4 17 symptoms purple 4, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 798 Malaise and fatigue Both 25 39 17 symptoms purple 39, 25 9, 5 10, 1 9, 7 10, 12 0.238 0.317 0.454 0.343 1.27 0.713 2.38 -1.56 1.22 0.2 0.7 0.21 1.22e-05 1.43 0.478 1.36 0.724 0.14 1.61 0.134 41.2 0.429 0.847 0.612 0.213 1.54 0.348 7.21 PRS_PLINK_1.58489319246107e.102 TRUE 798.1 Chronic fatigue syndrome Both 4 20 17 symptoms purple 20, 4 4, 0 5, 1 5, 2 5, 1 0.78 0.792 0.324 0.489 2.18 0.589 35.8 0.138 2.64 0.958 0.018 1.15 0.0156 47.1 2.02 4.55 0.658 0.182 7.5 0.0113 8720 0.537 7.87 0.946 0.024 1.71 1.5e-05 789000 PRS_PLINK_1.58489319246107e.102 TRUE 800 Fracture of lower limb Both 6 28 18 injuries & poisonings gray50 28, 6 7, 1 7, 0 7, 3 7, 2 0.165 0.56 0.769 0.114 1.18 0.433 3.74 -0.162 1.97 0.934 0.03 0.85 0.00922 108 0.771 1.74 0.657 0.182 2.16 0.0194 49.1 0.0795 1.8 0.965 0.016 1.08 0.0155 52.1 PRS_PLINK_1.58489319246107e.102 TRUE 800.1 Fracture of neck of femur Both 0 7 18 injuries & poisonings gray50 7, 0 2 2 1 2 PRS_PLINK_1.58489319246107e.102 TRUE 800.2 Fracture of unspecified part of femur Both 2 3 18 injuries & poisonings gray50 3, 2 1, 2 1, 0 1, 0 1, 2 -0.0589 2230 1 0 0.943 0.321 2.75 -0.781 18700 1 0 0.458 0.0433 4.48 -10.1 340000 1 0 4.13e-05 1.08e-33 3.1e+26 PRS_PLINK_1.58489319246107e.102 TRUE 800.3 Fracture of tibia and fibula Both 4 15 18 injuries & poisonings gray50 15, 4 4, 0 4, 0 3, 0 4, 4 0.245 0.889 0.783 0.106 1.28 0.288 15.6 3.03 5.84 0.604 0.219 20.7 0.00634 61300 PRS_PLINK_1.58489319246107e.102 TRUE 800.4 Fracture of patella Both 2 3 18 injuries & poisonings gray50 3, 2 1, 1 1, 0 1, 1 1, 1 0.0144 181 1 0 1.01 0.853 1.15 0.00847 28.1 1 0 1.01 0.924 1.08 -0.183 1550 1 0 0.833 0.822 1.49 PRS_PLINK_1.58489319246107e.102 TRUE 801 Fracture of ankle and foot Both 7 36 18 injuries & poisonings gray50 36, 7 9, 0 9, 1 9, 1 9, 4 0.147 0.447 0.742 0.13 1.16 0.529 2.88 0.677 1.45 0.639 0.194 1.97 0.117 7250 0.71 1.53 0.642 0.192 2.03 0.0755 131 2.24 1.95 0.249 0.604 9.42 0.443 31300 PRS_PLINK_1.58489319246107e.102 TRUE 801.1 Fracture of foot Both 2 14 18 injuries & poisonings gray50 14, 2 4, 0 3, 0 3, 0 4, 2 0.915 1.28 0.474 0.324 2.5 0.344 67.7 4.97 8.53 0.56 0.251 144 0.000544 1.59e+08 PRS_PLINK_1.58489319246107e.102 TRUE 802 Fracture of pelvis Both 0 5 18 injuries & poisonings gray50 5, 0 2 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 803 Fracture of upper limb Both 6 23 18 injuries & poisonings gray50 23, 6 6, 2 6, 1 5, 1 6, 2 -0.0147 0.531 0.978 0.01 0.985 0.359 2.71 0.179 1.86 0.923 0.035 1.2 0.022 122 0.499 2.12 0.814 0.089 1.65 0.0334 62800000 -0.305 1.83 0.867 0.062 0.737 0.00268 28 PRS_PLINK_1.58489319246107e.102 TRUE 803.1 Fracture of humerus Both 2 6 18 injuries & poisonings gray50 6, 2 2, 0 1, 0 1, 0 2, 2 0.0291 789 1 0 1.03 0.761 1.45 0.0761 904 1 0 1.08 0.708 1.77 PRS_PLINK_1.58489319246107e.102 TRUE 803.2 Fracture of radius and ulna Both 4 14 18 injuries & poisonings gray50 14, 4 4, 2 3, 0 3, 1 4, 1 -0.954 1.24 0.443 0.354 0.385 0.014 3.45 -1.24 8070000 1 0 0.29 0.000402 42.5 0.0627 240 1 0 1.06 2.43e-07 3800000 4.66 4.67 0.318 0.498 106 0.239 264000 PRS_PLINK_1.58489319246107e.102 TRUE 803.21 Colles' fracture Both 0 4 18 injuries & poisonings gray50 4, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 803.3 Fracture of clavicle or scapula Both 0 2 18 injuries & poisonings gray50 2, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 804 Fracture of hand or wrist Both 8 26 18 injuries & poisonings gray50 26, 8 7, 4 6, 1 6, 1 7, 2 -0.196 0.544 0.719 0.143 0.822 0.318 2.33 0.202 1.69 0.905 0.043 1.22 0.0501 16.7 -1.53 1.96 0.435 0.362 0.217 8.94e-05 40.4 1.1 1.67 0.509 0.293 3.02 0.203 461 PRS_PLINK_1.58489319246107e.102 TRUE 805 Fracture of vertebral column without mention of spinal cord injury Both 2 8 18 injuries & poisonings gray50 8, 2 2, 0 2, 0 2, 0 2, 2 1.04 2.77 0.707 0.15 2.83 0.0791 411 -0.0338 794 1 0 0.967 0.339 3.42 PRS_PLINK_1.58489319246107e.102 TRUE 807 Fracture of ribs Both 2 8 18 injuries & poisonings gray50 8, 2 2, 1 2, 0 2, 1 2, 0 -0.55 3.13 0.861 0.065 0.577 0.0599 5.42 -0.0377 3350 1 0 0.963 0.274 3.26 -0.00345 654 1 0 0.997 0.696 1.18 0.0511 2550 1 0 1.05 0.449 3.79 PRS_PLINK_1.58489319246107e.102 TRUE 809 Fracture of unspecified bones Both 6 37 18 injuries & poisonings gray50 37, 6 10, 1 9, 1 9, 0 9, 3 -0.184 0.612 0.764 0.117 0.832 0.233 3.36 0.434 1.29 0.737 0.133 1.54 0.152 78.1 -0.18 2.01 0.929 0.032 0.835 0.000954 102 1.25 1.71 0.464 0.334 3.5 0.586 115 PRS_PLINK_1.58489319246107e.102 TRUE 816 Cerebral laceration and contusion Both 0 3 18 injuries & poisonings gray50 3, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 817 Concussion Both 2 22 18 injuries & poisonings gray50 22, 2 6, 0 5, 0 5, 1 6, 1 0.388 0.739 0.599 0.222 1.47 0.338 545 0.65 5.28 0.902 0.045 1.92 0.000192 90400 0.742 2.54 0.77 0.113 2.1 0.0254 2510 PRS_PLINK_1.58489319246107e.102 TRUE 818 Intracranial hemorrhage (injury) Both 0 5 18 injuries & poisonings gray50 5, 0 2 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 818.1 Subdural hemorrhage (injury) Both 0 1 18 injuries & poisonings gray50 1, 0 PRS_PLINK_1.58489319246107e.102 TRUE 818.2 Subarachnoid hemorrhage (injury) Both 0 4 18 injuries & poisonings gray50 4, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 819 Skull and face fracture and other intercranial injury Both 4 37 18 injuries & poisonings gray50 37, 4 10, 0 9, 0 9, 1 9, 2 -0.536 0.575 0.351 0.455 0.585 0.0718 1.79 0.717 2.36 0.761 0.119 2.05 0.000305 1340 0.723 1.82 0.692 0.16 2.06 0.00474 2390 PRS_PLINK_1.58489319246107e.102 TRUE 830 Dislocation Both 12 42 18 injuries & poisonings gray50 42, 12 11, 4 10, 1 10, 3 11, 3 -0.189 0.352 0.592 0.228 0.828 0.422 1.6 -0.277 1.1 0.802 0.096 0.758 0.0889 12.1 -0.464 1.09 0.671 0.173 0.629 0.0531 4.48 0.573 1.08 0.594 0.226 1.77 0.276 20.7 PRS_PLINK_1.58489319246107e.102 TRUE 835 Internal derangement of knee Both 5 27 18 injuries & poisonings gray50 27, 5 7, 2 7, 1 6, 1 7, 1 0.107 0.553 0.847 0.072 1.11 0.417 3.76 -0.35 1.57 0.824 0.084 0.705 0.0272 19 1.04 1.69 0.538 0.269 2.83 0.124 2900 2.76 3.16 0.383 0.416 15.8 0.106 1090000 PRS_PLINK_1.58489319246107e.102 TRUE 836 Traumatic arthropathy Both 2 6 18 injuries & poisonings gray50 6, 2 2, 1 1, 0 1, 1 2, 0 0.0601 71.7 0.999 0 1.06 0.225 13.6 -0.147 4870 1 0 0.864 0.367 2.67 0.0194 20.3 0.999 0 1.02 0.92 1.41 -0.106 1140 1 0 0.9 0.55 1.45 PRS_PLINK_1.58489319246107e.102 TRUE 840 Sprains and strains Both 19 43 18 injuries & poisonings gray50 43, 19 10, 7 11, 1 10, 11 11, 0 -0.134 0.296 0.651 0.187 0.875 0.505 1.51 -0.874 1 0.384 0.415 0.417 0.0477 2.52 0.415 0.752 0.581 0.236 1.51 0.412 6.01 -2.3 1.54 0.135 0.87 0.1 2.29e-10 1.14 PRS_PLINK_1.58489319246107e.102 TRUE 840.1 Muscle/tendon sprain Both 2 3 18 injuries & poisonings gray50 3, 2 1, 2 1, 0 1, 0 1, 2 3.39 3000 0.999 0 29.7 0.00089 1830 0.109 1530 1 0 1.12 0.782 1.21 -0.161 2040 1 0 0.851 0.247 1.46 PRS_PLINK_1.58489319246107e.102 TRUE 840.2 Rotator cuff (capsule) sprain Both 7 16 18 injuries & poisonings gray50 16, 7 4, 1 4, 1 4, 5 4, 0 -0.122 0.542 0.822 0.085 0.885 0.35 2.21 1.17 251 0.996 0.002 3.21 2.98 6.85 0.854 1.79 0.634 0.198 2.35 0.208 60.4 0.287 6720000 1 0 1.33 0.0504 18.8 PRS_PLINK_1.58489319246107e.102 TRUE 840.3 Joint/ligament sprain Both 6 40 18 injuries & poisonings gray50 40, 6 9, 3 10, 1 10, 2 10, 0 -0.318 0.447 0.477 0.321 0.728 0.259 1.71 -0.313 1.08 0.771 0.113 0.731 0.0607 6.84 -0.511 1.41 0.717 0.144 0.6 0.0272 14.1 -1.36 1.5 0.364 0.439 0.256 3.87e-07 4.22 PRS_PLINK_1.58489319246107e.102 TRUE 841 Sprains and strains of back and neck Both 1 26 18 injuries & poisonings gray50 26, 1 6, 1 6, 0 6, 0 7, 0 -0.019 0.654 0.977 0.01 0.981 0.209 6.88 0.126 1.66 0.94 0.027 1.13 0.0241 3820 0.832 2.13 0.695 0.158 2.3 0.0741 138 -0.297 1.97 0.88 0.055 0.743 0.0185 30.2 PRS_PLINK_1.58489319246107e.102 TRUE 842 Other sprains and strains Both 4 23 18 injuries & poisonings gray50 23, 4 5, 3 6, 0 5, 1 6, 0 -0.853 0.77 0.268 0.573 0.426 0.0303 2 -2.11 2.23 0.345 0.462 0.122 0.000356 3.79 -1.96 2.29 0.391 0.408 0.141 0.00142 3.87 0.835 3.9 0.83 0.081 2.3 0.000509 201 PRS_PLINK_1.58489319246107e.102 TRUE 850 Hemorrhage or hematoma complicating a procedure Both 2 24 18 injuries & poisonings gray50 24, 2 5, 0 6, 1 6, 0 6, 1 0.559 0.72 0.438 0.359 1.75 0.245 75.6 -0.865 3.9 0.824 0.084 0.421 0.000124 8310 0.691 2.51 0.783 0.106 2 0.0162 203 PRS_PLINK_1.58489319246107e.102 TRUE 851 Complications of transplants and reattached limbs Both 2 34 18 injuries & poisonings gray50 34, 2 8, 0 8, 0 8, 0 9, 2 0.612 0.703 0.385 0.415 1.84 0.478 124 0.101 2.12 0.962 0.017 1.11 1.34e-05 4450 PRS_PLINK_1.58489319246107e.102 TRUE 853 Complication of colostomy or enterostomy Both 0 3 18 injuries & poisonings gray50 3, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 854 Complications of cardiac/vascular device, implant, and graft Both 4 25 18 injuries & poisonings gray50 25, 4 6, 0 6, 0 6, 1 6, 3 0.648 0.646 0.315 0.501 1.91 0.649 26.1 0.107 2.6 0.967 0.015 1.11 0.00404 40 0.49 1.89 0.796 0.099 1.63 0.0689 47.1 PRS_PLINK_1.58489319246107e.102 TRUE 855 Complication of nervous system device, implant, and graft Both 1 2 18 injuries & poisonings gray50 2, 1 1, 1 1, 1 1, 1 1, 1 0.0107 25.8 1 0 1.01 0.974 1.04 PRS_PLINK_1.58489319246107e.102 TRUE 856 Vascular complications of surgery and medical procedures Both 0 2 18 injuries & poisonings gray50 2, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 857 Mechanical complication of unspecified genitourinary device, implant, and graft Both 4 20 18 injuries & poisonings gray50 20, 4 4, 0 5, 1 5, 2 5, 1 0.47 0.634 0.459 0.339 1.6 0.515 15.2 -2.88 21 0.891 0.05 0.0561 0.0464 0.0682 -1.67 3.53 0.635 0.197 0.187 7.77e-07 1060 -1.13 4.22 0.79 0.103 0.324 0.292 0.367 PRS_PLINK_1.58489319246107e.102 TRUE 858 Complication of internal orthopedic device Both 2 23 18 injuries & poisonings gray50 23, 2 6, 1 6, 0 5, 1 6, 0 -0.0428 0.678 0.95 0.022 0.958 0.257 5.04 0.0322 2.88 0.991 0.004 1.03 0.00339 308 0.515 2.54 0.839 0.076 1.67 0.0026 151 0.166 2.37 0.944 0.025 1.18 0.00221 86.6 PRS_PLINK_1.58489319246107e.102 TRUE 859 Complication due to other implant and internal device Both 1 21 18 injuries & poisonings gray50 21, 1 5, 0 5, 0 5, 0 5, 1 0.396 0.787 0.615 0.211 1.49 0.255 104 -0.515 4.25 0.904 0.044 0.598 0.564 0.651 PRS_PLINK_1.58489319246107e.102 TRUE 860 Bone marrow or stem cell transplant Both 0 3 2 neoplasms darkcyan 3, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 870 Open wounds of head; neck; and trunk Both 5 48 18 injuries & poisonings gray50 48, 5 11, 1 12, 3 12, 1 12, 0 -0.243 0.389 0.532 0.274 0.784 0.353 1.71 1.24 1.24 0.318 0.497 3.46 0.384 79.4 0.0439 1.11 0.968 0.014 1.04 0.0486 14.7 -0.48 1.46 0.742 0.13 0.619 0.00991 15.7 PRS_PLINK_1.58489319246107e.102 TRUE 870.1 Open wound or laceration of eye or eyelid Both 0 2 18 injuries & poisonings gray50 2, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 870.2 Open wound of ear Both 0 3 18 injuries & poisonings gray50 3, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 870.3 Other open wound of head and face Both 1 13 18 injuries & poisonings gray50 13, 1 3, 1 3, 0 3, 0 3, 0 0.743 1.4 0.595 0.226 2.1 0.186 45.5 -0.0891 1290 1 0 0.915 0.363 1.57 -0.248 2730000 1 0 0.78 0.0604 4.59 -0.0931 1150 1 0 0.911 0.3 1.56 PRS_PLINK_1.58489319246107e.102 TRUE 870.4 Open wound of nose and sinus Both 1 2 18 injuries & poisonings gray50 2, 1 1, 1 1, 0 1, 1 1, 0 0.00873 61.8 1 0 1.01 0.869 1.16 -0.00168 15.4 1 0 0.998 0.964 1.07 PRS_PLINK_1.58489319246107e.102 TRUE 870.5 Open wound of lip and mouth Both 0 7 18 injuries & poisonings gray50 7, 0 2 2 1 2 PRS_PLINK_1.58489319246107e.102 TRUE 870.6 Open wound of neck Both 0 1 18 injuries & poisonings gray50 1, 0 PRS_PLINK_1.58489319246107e.102 TRUE 870.8 Open wound of genital organs Both 1 1 18 injuries & poisonings gray50 1, 1 0.00227 184 1 0 1 0.986 1.02 PRS_PLINK_1.58489319246107e.102 TRUE 871 Open wounds of extremities Both 7 49 18 injuries & poisonings gray50 49, 7 12, 1 12, 1 12, 3 12, 2 1.29 0.875 0.14 0.854 3.64 0.686 92.1 0.54 1.25 0.665 0.177 1.72 0.0617 78.1 1.02 1.23 0.407 0.39 2.78 0.301 302 0.827 1.41 0.556 0.255 2.29 0.126 2440000 PRS_PLINK_1.58489319246107e.102 TRUE 871.1 Open wound of hand except finger(s) Both 1 13 18 injuries & poisonings gray50 13, 1 4, 0 3, 0 3, 1 3, 0 -0.237 0.845 0.779 0.108 0.789 0.159 5.01 0.246 95.6 0.998 0.001 1.28 2.49 16.9 PRS_PLINK_1.58489319246107e.102 TRUE 871.2 Open wound of finger(s) Both 4 25 18 injuries & poisonings gray50 25, 4 7, 0 6, 2 6, 1 6, 1 0.456 0.918 0.619 0.208 1.58 0.228 3880 0.119 1.77 0.946 0.024 1.13 0.00661 203 -0.356 3.6 0.921 0.036 0.7 0.00137 237000 0.419 2.41 0.862 0.065 1.52 0.0202 1010 PRS_PLINK_1.58489319246107e.102 TRUE 871.3 Open wound of foot except toe(s) alone Both 1 12 18 injuries & poisonings gray50 12, 1 3, 0 3, 0 3, 1 3, 0 0.00497 1.49 0.997 0.001 1 0.049 31.5 -0.0469 96.8 1 0 0.954 0.554 1.48 PRS_PLINK_1.58489319246107e.102 TRUE 871.4 Open wound of toe(s) Both 2 9 18 injuries & poisonings gray50 9, 2 3, 0 2, 1 2, 1 2, 0 0.0491 2.89 0.986 0.006 1.05 0.0131 100 0.63 833 0.999 0 1.88 0.417 9.35 0.153 3020 1 0 1.17 0.333 4.96 PRS_PLINK_1.58489319246107e.102 TRUE 872 Traumatic amputation Both 1 15 18 injuries & poisonings gray50 15, 1 4, 1 4, 0 3, 0 4, 0 -0.324 0.873 0.71 0.149 0.723 0.114 6.94 -0.0126 12.1 0.999 0 0.988 0.672 1.62 -0.0126 15.9 0.999 0 0.987 0.457 1.14 -0.618 6590 1 0 0.539 0.00623 27.6 PRS_PLINK_1.58489319246107e.102 TRUE 874 Complication of amputation stump Both 0 3 18 injuries & poisonings gray50 3, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 875 Non-healing surgical wound Both 0 4 18 injuries & poisonings gray50 4, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 876 Posttraumatic wound infection not elsewhere classified Both 0 9 18 injuries & poisonings gray50 9, 0 3 2 2 2 PRS_PLINK_1.58489319246107e.102 TRUE 907 Injuries to the nervous system Both 2 16 18 injuries & poisonings gray50 16, 2 4, 0 4, 0 4, 2 4, 0 0.399 0.892 0.655 0.184 1.49 0.366 20.9 0.484 1.61 0.764 0.117 1.62 0.16 28 PRS_PLINK_1.58489319246107e.102 TRUE 910 Superficial injury, infected Both 0 3 18 injuries & poisonings gray50 3, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 911 Blister Both 5 8 18 injuries & poisonings gray50 8, 5 2, 1 2, 0 2, 0 2, 3 0.0441 1.6 0.978 0.01 1.05 0.0259 23.1 0.0941 4240 1 0 1.1 0.214 6.35 -0.114 4920 1 0 0.892 0.113 6.48 0.485 9460000 1 0 1.62 0.00248 2790 PRS_PLINK_1.58489319246107e.102 TRUE 912 Insect bite Both 0 9 18 injuries & poisonings gray50 9, 0 3 2 2 2 PRS_PLINK_1.58489319246107e.102 TRUE 913 Toxic effect of venom Both 2 6 18 injuries & poisonings gray50 6, 2 2, 1 1, 0 1, 0 2, 1 0.764 148 0.996 0.002 2.15 1.35e-05 156000 -0.246 9120 1 0 0.782 0.132 2.32 -0.466 20800 1 0 0.627 0.00324 4.83 -1.76 1.8e+08 1 0 0.172 1.42e-05 20.5 PRS_PLINK_1.58489319246107e.102 TRUE 916 Contusion Both 8 48 18 injuries & poisonings gray50 48, 8 12, 2 12, 0 12, 4 12, 1 -0.229 0.392 0.558 0.253 0.795 0.364 1.75 -0.79 1.2 0.51 0.293 0.454 0.00507 5.21 0.715 1.07 0.505 0.296 2.04 0.299 19.9 -0.966 1.55 0.534 0.272 0.381 2.03e-05 9.84 PRS_PLINK_1.58489319246107e.102 TRUE 930 Allergic reaction to food Both 0 10 18 injuries & poisonings gray50 10, 0 3 2 2 3 PRS_PLINK_1.58489319246107e.102 TRUE 931 Contact dermatitis and other eczema due to plants [except food] Both 1 11 13 dermatologic firebrick 11, 1 2, 0 3, 0 2, 1 3, 0 -0.159 0.84 0.85 0.07 0.853 0.129 3.48 -1.13 6020 1 0 0.323 0.281 3.53 PRS_PLINK_1.58489319246107e.102 TRUE 938 Dermatitis due to solar radiation Both 8 32 13 dermatologic firebrick 32, 8 7, 2 8, 3 8, 1 8, 2 0.207 0.429 0.629 0.201 1.23 0.565 2.91 -0.246 1.68 0.884 0.054 0.782 0.0171 357 0.0472 2.04 0.982 0.008 1.05 0.00486 345 0.701 1.26 0.579 0.237 2.02 0.271 93.5 PRS_PLINK_1.58489319246107e.102 TRUE 938.1 Acute dermatitis due to solar radiation Both 0 4 13 dermatologic firebrick 4, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 938.2 Chronic dermatitis due to solar radiation Both 8 31 13 dermatologic firebrick 31, 8 7, 2 8, 3 7, 1 8, 2 0.206 0.428 0.631 0.2 1.23 0.565 2.89 -0.246 1.68 0.884 0.054 0.782 0.0171 357 0.0435 2.02 0.983 0.008 1.04 0.00524 314 0.823 1.28 0.52 0.284 2.28 0.304 69.9 PRS_PLINK_1.58489319246107e.102 TRUE 939 Atopic/contact dermatitis due to other or unspecified Both 12 40 13 dermatologic firebrick 40, 12 9, 3 10, 0 10, 5 10, 4 0.828 0.502 0.0991 1.004 2.29 0.944 7.68 -0.627 1.45 0.664 0.178 0.534 0.00577 11.3 1.93 1.63 0.237 0.625 6.86 0.438 186000 2.15 1.65 0.192 0.717 8.62 0.608 1020 PRS_PLINK_1.58489319246107e.102 TRUE 939.1 Contact and allergic dermatitis of eyelid Both 0 1 13 dermatologic firebrick 1, 0 PRS_PLINK_1.58489319246107e.102 TRUE 941 Adverse reaction to serum or vaccine Both 0 5 18 injuries & poisonings gray50 5, 0 2 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 942 Infusion and transfusion reaction Both 0 4 18 injuries & poisonings gray50 4, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 946 Anaphylactic shock NOS Both 3 5 18 injuries & poisonings gray50 5, 3 2, 0 1, 0 1, 1 1, 2 -0.498 485 0.999 0 0.608 0.0262 9.59 0.3 8540 1 0 1.35 0.336 1.95 -0.091 713 1 0 0.913 0.341 1.24 PRS_PLINK_1.58489319246107e.102 TRUE 947 Urticaria Both 5 15 13 dermatologic firebrick 15, 5 3, 2 4, 1 3, 2 4, 0 0.0159 0.74 0.983 0.008 1.02 0.241 4.05 -0.584 3.23 0.856 0.067 0.558 0.024 10.7 3.69 26.7 0.89 0.051 40.1 32.4 50.1 1.64 528 0.998 0.001 5.14 199 1590 PRS_PLINK_1.58489319246107e.102 TRUE 949 Allergies, other Both 13 40 18 injuries & poisonings gray50 40, 13 9, 0 10, 3 10, 8 10, 2 0.576 0.418 0.168 0.775 1.78 0.852 4.61 1.43 1.47 0.332 0.478 4.17 0.323 844 1.71 1.65 0.298 0.525 5.53 0.394 187000 1.33 1.79 0.458 0.339 3.77 0.111 4200 PRS_PLINK_1.58489319246107e.102 TRUE 952 Spinal cord injury without evidence of spinal bone injury Both 1 8 18 injuries & poisonings gray50 8, 1 2, 0 2, 0 2, 1 2, 0 -0.612 240 0.998 0.001 0.542 0.0521 9.37 0.117 1500 1 0 1.12 0.729 1.94 PRS_PLINK_1.58489319246107e.102 TRUE 957 Injury to other and unspecified nerves Both 1 1 18 injuries & poisonings gray50 1, 1 0.000398 403 1 0 1 0.992 1 PRS_PLINK_1.58489319246107e.102 TRUE 958 Certain early complications of trauma or procedure Both 0 10 18 injuries & poisonings gray50 10, 0 3 2 2 3 PRS_PLINK_1.58489319246107e.102 TRUE 958.1 Postoperative shock Both 0 2 18 injuries & poisonings gray50 2, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 960 Poisoning by antibiotics Both 5 26 18 injuries & poisonings gray50 26, 5 6, 2 6, 0 6, 3 7, 0 -0.46 0.476 0.333 0.477 0.631 0.22 1.37 -0.19 3.55 0.957 0.019 0.827 0.00165 222 -1.19 2.23 0.595 0.225 0.305 0.00589 10 -1.28 2.46 0.602 0.22 0.277 0.000328 113 PRS_PLINK_1.58489319246107e.102 TRUE 960.1 Adverse effects of antibacterials (not penicillins) Both 0 3 18 injuries & poisonings gray50 3, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 960.2 Allergy/adverse effect of penicillin Both 3 19 18 injuries & poisonings gray50 19, 3 4, 1 5, 0 4, 2 5, 0 -0.192 0.703 0.785 0.105 0.825 0.0689 9.95 -1.26 15.2 0.934 0.03 0.283 0.263 0.303 -0.125 410 1 0 0.882 0.853 1.14 -3.2 12.6 0.8 0.097 0.0409 8.93e-11 16400000 PRS_PLINK_1.58489319246107e.102 TRUE 961 Poisoning by other anti-infectives Both 0 9 18 injuries & poisonings gray50 9, 0 3 2 2 2 PRS_PLINK_1.58489319246107e.102 TRUE 961.1 Poisoning/allergy of sulfonamides Both 2 6 18 injuries & poisonings gray50 6, 2 2, 0 1, 1 1, 0 2, 1 0.737 124 0.995 0.002 2.09 0.000803 5050 -0.449 5200 1 0 0.638 0.398 2.46 -0.0401 13500 1 0 0.961 0.454 15.5 PRS_PLINK_1.58489319246107e.102 TRUE 962 Poisoning by hormones and synthetic substitutes Both 3 16 18 injuries & poisonings gray50 16, 3 4, 2 4, 0 4, 1 4, 0 -0.768 0.913 0.4 0.398 0.464 0.0428 3.08 -0.0336 200 1 0 0.967 0.73 1.7 -0.858 6.18 0.89 0.051 0.424 3.22e-05 41900 -0.199 132 0.999 0.001 0.819 0.468 0.993 PRS_PLINK_1.58489319246107e.102 TRUE 962.1 Adrenal cortical steroids causing adverse effects in therapeutic use Both 1 8 18 injuries & poisonings gray50 8, 1 2, 0 2, 0 2, 1 2, 0 9.89e-13 41.4 1 0 1 0.000188 5550 -0.000295 1430 1 0 1 0.635 2.4 PRS_PLINK_1.58489319246107e.102 TRUE 962.2 Insulins and antidiabetic agents causing adverse effects in therapeutic use Both 1 1 18 injuries & poisonings gray50 1, 1 0.00285 402 1 0 1 0.983 1.02 PRS_PLINK_1.58489319246107e.102 TRUE 962.3 Hormones and synthetic substitutes causing adverse effects in therapeutic use Both 2 9 18 injuries & poisonings gray50 9, 2 3, 1 2, 1 2, 0 2, 0 -0.767 2.5 0.759 0.12 0.464 0.446 0.482 -0.406 361 0.999 0 0.666 0.0971 3.71 -0.0717 3120 1 0 0.931 0.483 1.6 -0.0416 460 1 0 0.959 0.574 1.33 PRS_PLINK_1.58489319246107e.102 TRUE 963 Poisoning by primarily systemic agents Both 0 25 18 injuries & poisonings gray50 25, 0 6 6 6 6 PRS_PLINK_1.58489319246107e.102 TRUE 963.1 Antineoplastic and immunosuppressive drugs causing adverse effects Both 0 23 18 injuries & poisonings gray50 23, 0 5 6 5 6 PRS_PLINK_1.58489319246107e.102 TRUE 964 Poisoning by agents primarily affecting blood constituents Both 0 13 18 injuries & poisonings gray50 13, 0 3 3 3 3 PRS_PLINK_1.58489319246107e.102 TRUE 964.1 Anticoagulants causing adverse effects Both 0 12 18 injuries & poisonings gray50 12, 0 2 3 3 3 PRS_PLINK_1.58489319246107e.102 TRUE 965 Poisoning by analgesics, antipyretics, and antirheumatics Both 1 5 18 injuries & poisonings gray50 5, 1 2, 0 1, 0 1, 0 1, 1 1.12 14500000 1 0 3.07 0.00903 681 0.154 91500 1 0 1.17 1.69e-11 4.58 PRS_PLINK_1.58489319246107e.102 TRUE 965.1 Opiates and related narcotics causing adverse effects in therapeutic use Both 1 16 18 injuries & poisonings gray50 16, 1 3, 0 4, 0 4, 0 4, 1 0.0551 0.644 0.932 0.031 1.06 0.329 4.16 0.0615 1480 1 0 1.06 0.0207 86.8 PRS_PLINK_1.58489319246107e.102 TRUE 965.3 Salicylates causing adverse effects in therapeutic use Both 0 1 18 injuries & poisonings gray50 1, 0 PRS_PLINK_1.58489319246107e.102 TRUE 966 Poisoning by anticonvulsants and anti-Parkinsonism drugs Both 0 2 18 injuries & poisonings gray50 2, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 967 Adverse effects of sedatives or other central nervous system depressants and anesthetics Both 0 12 18 injuries & poisonings gray50 12, 0 3 3 3 3 PRS_PLINK_1.58489319246107e.102 TRUE 969 Poisoning by psychotropic agents Both 0 1 18 injuries & poisonings gray50 1, 0 PRS_PLINK_1.58489319246107e.102 TRUE 972 Poisoning by agents primarily affecting the cardiovascular system Both 0 4 18 injuries & poisonings gray50 4, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 972.6 Antihypertensive agents causing adverse effects Both 0 1 18 injuries & poisonings gray50 1, 0 PRS_PLINK_1.58489319246107e.102 TRUE 974 Poisoning by water, mineral, and uric acid metabolism drugs Both 0 1 18 injuries & poisonings gray50 1, 0 PRS_PLINK_1.58489319246107e.102 TRUE 975 Poisoning by agents primarily acting on the smooth and skeletal muscles and respiratory system Both 0 1 18 injuries & poisonings gray50 1, 0 PRS_PLINK_1.58489319246107e.102 TRUE 976 Poisoning by agents primarily affecting skin & mucous membrane, ophthalmological, otorhinolaryngological, & dental drugs Both 1 0 18 injuries & poisonings gray50 0, 1 PRS_PLINK_1.58489319246107e.102 TRUE 977 Personal history of allergy to medicinal agents Both 0 21 18 injuries & poisonings gray50 21, 0 5 5 5 5 PRS_PLINK_1.58489319246107e.102 TRUE 979 Adverse drug events and drug allergies Both 5 38 18 injuries & poisonings gray50 38, 5 9, 1 9, 0 9, 2 10, 2 -0.0351 0.495 0.943 0.025 0.966 0.352 3.05 -1.27 1.44 0.378 0.423 0.28 0.000725 3.25 -0.561 1.64 0.733 0.135 0.571 0.00409 14.6 -1.21 1.89 0.52 0.284 0.297 0.000291 29.1 PRS_PLINK_1.58489319246107e.102 TRUE 980 Encounter for long-term (current) use of antibiotics Both 3 13 1 infectious diseases blue 13, 3 3, 0 3, 0 3, 1 3, 2 0.743 0.921 0.42 0.377 2.1 0.479 21.7 0.00193 915 1 0 1 0.679 1.94 1.26 904 0.999 0 3.53 0.0348 15.8 PRS_PLINK_1.58489319246107e.102 TRUE 985 Toxic effect of other metals Both 1 0 18 injuries & poisonings gray50 0, 1 PRS_PLINK_1.58489319246107e.102 TRUE 989 Toxic effect of other substances, chiefly nonmedicinal as to source Both 1 2 18 injuries & poisonings gray50 2, 1 1, 1 1, 0 1, 1 1, 0 0.0308 69.5 1 0 1.03 0.95 1.14 -0.0444 192 1 0 0.957 0.748 1.17 PRS_PLINK_1.58489319246107e.102 TRUE 990 Effects radiation NOS Both 0 21 18 injuries & poisonings gray50 21, 0 6 5 5 5 PRS_PLINK_1.58489319246107e.102 TRUE 994 Sepsis and SIRS Both 1 27 18 injuries & poisonings gray50 27, 1 7, 0 7, 0 6, 1 7, 0 0.00993 0.7 0.989 0.005 1.01 0.28 16.9 0.469 1.56 0.764 0.117 1.6 0.124 20.8 PRS_PLINK_1.58489319246107e.102 TRUE 994.1 Systemic inflammatory response syndrome (SIRS) Both 0 2 18 injuries & poisonings gray50 2, 0 1 1 1 1 PRS_PLINK_1.58489319246107e.102 TRUE 994.2 Sepsis Both 1 27 18 injuries & poisonings gray50 27, 1 7, 0 7, 0 6, 1 7, 0 0.0459 0.698 0.948 0.023 1.05 0.275 19.8 1.03 2.23 0.643 0.192 2.81 0.0998 674 PRS_PLINK_1.58489319246107e.102 TRUE 994.21 Septic shock Both 0 6 18 injuries & poisonings gray50 6, 0 2 1 1 2 PRS_PLINK_1.58489319246107e.102 TRUE