phewas_code phewas_string sex MatchedCases MatchedControls groupnum group color N N_Q1 N_Q2 N_Q3 N_Q4 PRS_BETA PRS_SEBETA PRS_P PRS_LOG10P PRS_OR PRS_CI1 PRS_CI2 Q1Q2_BETA Q1Q2_SEBETA Q1Q2_P Q1Q2_LOG10P Q1Q2_OR Q1Q2_CI1 Q1Q2_CI2 Q1Q3_BETA Q1Q3_SEBETA Q1Q3_P Q1Q3_LOG10P Q1Q3_OR Q1Q3_CI1 Q1Q3_CI2 Q1Q4_BETA Q1Q4_SEBETA Q1Q4_P Q1Q4_LOG10P Q1Q4_OR Q1Q4_CI1 Q1Q4_CI2 predictor 008 Intestinal infection Both 7 45 1 infectious diseases blue 45, 7 11, 0 11, 1 11, 3 11, 3 0.493 0.555 0.374 0.427 1.64 0.596 6.75 0.102 1.66 0.951 0.022 1.11 0.0197 93.8 0.621 1.57 0.693 0.159 1.86 0.072 163 1.11 1.68 0.51 0.292 3.03 0.125 1.22e+11 PRS_PLINK_1e.05 008.5 Bacterial enteritis Both 2 16 1 infectious diseases blue 16, 2 4, 0 4, 0 4, 1 4, 1 1.37 1.82 0.45 0.347 3.95 0.131 1340 -0.305 1230 1 0 0.737 0.658 1.09 0.444 259 0.999 0.001 1.56 1.82 2.81 PRS_PLINK_1e.05 008.52 Intestinal infection due to C. difficile Both 1 11 1 infectious diseases blue 11, 1 3, 0 3, 0 2, 1 3, 0 -0.61 2.97 0.837 0.077 0.543 0.000939 52.7 -0.092 2710 1 0 0.912 0.229 1.48 PRS_PLINK_1e.05 008.6 Viral Enteritis Both 1 13 1 infectious diseases blue 13, 1 4, 0 3, 0 3, 0 3, 1 -0.00857 1.19 0.994 0.003 0.991 0.144 18.7 0.0616 191 1 0 1.06 0.33 2.48 PRS_PLINK_1e.05 010 Tuberculosis Both 2 3 1 infectious diseases blue 3, 2 1, 1 1, 1 1, 0 1, 1 -0.0889 1410 1 0 0.915 0.312 1.69 -2.18 3.02e+09 1 0 0.113 3.46e-26 1.04e+20 0.0509 71.4 0.999 0 1.05 0.719 1.13 PRS_PLINK_1e.05 031 Diseases due to other mycobacteria Both 1 2 1 infectious diseases blue 2, 1 1, 0 1, 1 1, 0 1, 1 -0.0718 3490 1 0 0.931 0.898 3.04 -0.0322 280 1 0 0.968 0.771 1.14 PRS_PLINK_1e.05 038 Septicemia Both 1 34 1 infectious diseases blue 34, 1 9, 0 8, 0 8, 1 9, 0 0.178 0.681 0.794 0.1 1.19 0.253 22.5 1.2 2.16 0.577 0.238 3.33 0.0513 593 PRS_PLINK_1e.05 038.1 Gram negative septicemia Both 1 9 1 infectious diseases blue 9, 1 3, 0 2, 0 2, 1 2, 0 0.331 4.5 0.941 0.026 1.39 0.000738 1190 0.0367 1930 1 0 1.04 0.636 1.77 PRS_PLINK_1e.05 038.2 Gram positive septicemia Both 0 3 1 infectious diseases blue 3, 0 1 1 1 1 PRS_PLINK_1e.05 038.3 Bacteremia Both 0 18 1 infectious diseases blue 18, 0 5 4 4 5 PRS_PLINK_1e.05 041 Bacterial infection NOS Both 4 52 1 infectious diseases blue 52, 4 12, 0 13, 1 13, 0 13, 3 0.505 0.519 0.331 0.48 1.66 0.571 7.31 0.611 1.3 0.637 0.196 1.84 0.154 505 0.412 1.51 0.785 0.105 1.51 0.0511 328 PRS_PLINK_1e.05 041.1 Staphylococcus infections Both 2 26 1 infectious diseases blue 26, 2 7, 0 6, 0 6, 0 7, 2 0.105 0.645 0.87 0.06 1.11 0.105 5.31 0.122 1.61 0.94 0.027 1.13 0.00303 100 PRS_PLINK_1e.05 041.11 Methicillin sensitive Staphylococcus aureus Both 2 16 1 infectious diseases blue 16, 2 4, 0 4, 0 4, 0 4, 2 0.665 1.05 0.528 0.278 1.94 0.242 19.4 -0.297 3.54 0.933 0.03 0.743 0.00304 200 PRS_PLINK_1e.05 041.12 Methicillin resistant Staphylococcus aureus Both 2 14 1 infectious diseases blue 14, 2 4, 0 3, 0 3, 0 4, 2 0.0762 2.24 0.973 0.012 1.08 0.0072 121 0.385 5.28 0.942 0.026 1.47 0.00105 8680 PRS_PLINK_1e.05 041.2 Streptococcus infection Both 2 17 1 infectious diseases blue 17, 2 5, 0 4, 0 4, 1 4, 1 0.471 0.856 0.583 0.235 1.6 0.313 17.8 9.29e-11 84.7 1 0 1 3.23e-05 30700 0.13 7.3 0.986 0.006 1.14 1.1 1.18 PRS_PLINK_1e.05 041.21 Rheumatic fever / chorea Both 0 1 1 infectious diseases blue 1, 0 PRS_PLINK_1e.05 041.4 E. coli Both 2 12 1 infectious diseases blue 12, 2 3, 0 3, 0 3, 1 3, 1 0.59 1.43 0.679 0.168 1.8 0.244 322 0.224 5830 1 0 1.25 0.0145 123 -1.24e-05 5030 1 0 1 0.112 2.49 PRS_PLINK_1e.05 041.8 H. pylori Both 0 2 1 infectious diseases blue 2, 0 1 1 1 1 PRS_PLINK_1e.05 041.9 Infection with drug-resistant microorganisms Both 0 5 1 infectious diseases blue 5, 0 1 1 1 1 PRS_PLINK_1e.05 053 Herpes zoster Both 3 22 1 infectious diseases blue 22, 3 6, 1 5, 1 5, 0 6, 1 0.168 0.868 0.846 0.072 1.18 0.117 9.06 -0.29 2.01 0.886 0.053 0.749 0.0259 30.6 0.0742 943 1 0 1.08 0.526 1.19 2.25 7.2 0.755 0.122 9.46 0.00011 23300000 PRS_PLINK_1e.05 053.1 Herpes zoster with nervous system complications Both 1 3 1 infectious diseases blue 3, 1 1, 0 1, 0 1, 1 1, 0 -0.0025 5560 1 0 0.998 0.493 2.49 0.00757 50.1 1 0 1.01 0.894 1.18 PRS_PLINK_1e.05 054 Herpes simplex Both 3 22 1 infectious diseases blue 22, 3 5, 1 5, 0 5, 0 6, 2 -0.573 0.798 0.473 0.325 0.564 0.0467 3.93 -0.0253 2.24 0.991 0.004 0.975 0.0267 28.5 -0.0559 2.51 0.982 0.008 0.946 0.0085 31.6 -2.9 3.75 0.439 0.357 0.0552 4.3e-05 17.6 PRS_PLINK_1e.05 070 Viral hepatitis Both 1 8 1 infectious diseases blue 8, 1 2, 0 2, 0 2, 0 2, 1 0.735 8160000 1 0 2.08 1.24 3.37 0.0145 304 1 0 1.01 0.926 1.36 PRS_PLINK_1e.05 070.2 Viral hepatitis B Both 1 1 1 infectious diseases blue 1, 1 -0.0137 72.6 1 0 0.986 0.939 1.04 PRS_PLINK_1e.05 070.3 Viral hepatitis C Both 0 7 1 infectious diseases blue 7, 0 2 2 1 2 PRS_PLINK_1e.05 070.4 Chronic hepatitis Both 0 1 1 infectious diseases blue 1, 0 PRS_PLINK_1e.05 070.9 Hepatitis NOS Both 3 9 1 infectious diseases blue 9, 3 3, 1 2, 0 2, 1 2, 1 0.843 5.41 0.876 0.057 2.32 1.99 2.56 -0.479 2680 1 0 0.619 0.0155 5.12 0.0345 841 1 0 1.04 0.856 1.32 0.151 411 1 0 1.16 0.949 1.53 PRS_PLINK_1e.05 071 Human immunodeficiency virus [HIV] disease Both 0 2 1 infectious diseases blue 2, 0 1 1 1 1 PRS_PLINK_1e.05 071.1 HIV infection, symptomatic Both 0 2 1 infectious diseases blue 2, 0 1 1 1 1 PRS_PLINK_1e.05 078 Viral warts & HPV Both 10 34 1 infectious diseases blue 34, 10 8, 2 8, 4 8, 1 9, 3 0.058 0.453 0.898 0.047 1.06 0.462 2.84 0.534 1.42 0.708 0.15 1.71 0.13 84.4 1.23 1.71 0.473 0.325 3.41 0.0887 425 1.57 1.9 0.407 0.391 4.82 0.131 635 PRS_PLINK_1e.05 079 Viral infection Both 13 38 1 infectious diseases blue 38, 13 9, 4 9, 0 9, 2 10, 7 0.0471 0.356 0.895 0.048 1.05 0.542 2.05 -0.979 1.85 0.597 0.224 0.376 0.000623 11.9 -0.0763 1.31 0.954 0.021 0.927 0.0714 10.2 0.0938 1.2 0.938 0.028 1.1 0.137 10.2 PRS_PLINK_1e.05 079.1 Varicella infection Both 8 32 1 infectious diseases blue 32, 8 8, 3 8, 0 8, 0 8, 5 -0.0307 0.506 0.952 0.022 0.97 0.37 2.71 0.459 1.91 0.81 0.091 1.58 0.00927 236 0.167 1.81 0.927 0.033 1.18 0.00418 228 0.723 1.52 0.635 0.197 2.06 0.175 75.5 PRS_PLINK_1e.05 079.2 Infectious mononucleosis Both 0 4 1 infectious diseases blue 4, 0 1 1 1 1 PRS_PLINK_1e.05 079.9 Viremia, NOS Both 2 12 1 infectious diseases blue 12, 2 2, 0 3, 0 3, 1 3, 1 -0.0446 0.999 0.964 0.016 0.956 0.152 16.6 0.00901 982 1 0 1.01 0.699 1.52 0.868 6410 1 0 2.38 0.0506 152 PRS_PLINK_1e.05 080 Postoperative infection Both 0 29 1 infectious diseases blue 29, 0 8 7 7 7 PRS_PLINK_1e.05 081 Infection/inflammation of internal prosthetic device; implant; and graft Both 3 15 1 infectious diseases blue 15, 3 4, 0 4, 0 3, 1 4, 2 0.923 1.27 0.469 0.329 2.52 0.3 615 0.00244 151 1 0 1 0.648 1.36 -3.02e-12 23.3 1 0 1 6.18e-12 3.53e+10 PRS_PLINK_1e.05 090 Sexually transmitted infections (not HIV or hepatitis) Both 2 19 1 infectious diseases blue 19, 2 5, 1 5, 1 4, 0 5, 0 -0.302 0.728 0.678 0.169 0.739 0.0176 2.76 -0.00179 202 1 0 0.998 0.519 1.13 -1.03 3.11 0.741 0.13 0.358 0.00205 30 -0.84 2.83 0.767 0.115 0.432 0.00195 675 PRS_PLINK_1e.05 110 Dermatophytosis / Dermatomycosis Both 13 33 1 infectious diseases blue 33, 13 9, 3 8, 6 8, 2 8, 2 -0.101 0.427 0.812 0.09 0.904 0.375 2 0.622 1.04 0.552 0.258 1.86 0.306 14 0.206 1.43 0.885 0.053 1.23 8.84e-05 18.5 0.317 1.27 0.803 0.095 1.37 0.0199 18.3 PRS_PLINK_1e.05 110.1 Dermatophytosis Both 13 31 1 infectious diseases blue 31, 13 8, 3 8, 4 7, 4 8, 2 -0.0164 0.437 0.97 0.013 0.984 0.417 2.27 -0.0607 1.42 0.966 0.015 0.941 0.0618 17.3 -0.586 1.86 0.752 0.124 0.557 0.000168 18.2 -0.736 1.3 0.572 0.243 0.479 0.00226 5.17 PRS_PLINK_1e.05 110.11 Dermatophytosis of nail Both 9 18 1 infectious diseases blue 18, 9 5, 2 4, 2 4, 3 5, 2 0.0387 0.737 0.958 0.019 1.04 0.204 5.23 0.0353 165 1 0 1.04 0.884 2.11 1.63 4.32 0.706 0.151 5.12 0.00206 129000 -0.135 1.9 0.943 0.025 0.874 0.0422 1800 PRS_PLINK_1e.05 110.12 Althete's foot Both 4 15 1 infectious diseases blue 15, 4 4, 1 4, 3 3, 0 4, 0 -1.02 1.11 0.354 0.451 0.359 0.0253 2.03 0.0242 2.49 0.992 0.003 1.02 0.000616 137 0.0206 786 1 0 1.02 0.647 2.89 0.0308 592 1 0 1.03 0.771 1.05 PRS_PLINK_1e.05 110.13 Dermatophytosis of the body Both 2 16 1 infectious diseases blue 16, 2 4, 0 4, 1 4, 1 4, 0 0.133 0.729 0.855 0.068 1.14 0.328 47 -18.1 56100000 1 0 1.39e-08 2.27e-31 644000 -0.0681 761 1 0 0.934 6.91 9.61 PRS_PLINK_1e.05 110.2 Dermatomycoses Both 2 7 1 infectious diseases blue 7, 2 2, 1 2, 1 1, 0 2, 0 -0.414 8.22 0.96 0.018 0.661 0.14 3.11 0.0292 339 1 0 1.03 0.532 8.48 0.106 6000 1 0 1.11 0.182 7.81 0.576 1760 1 0 1.78 0.0992 22.9 PRS_PLINK_1e.05 112 Candidiasis Both 7 35 1 infectious diseases blue 35, 7 8, 0 9, 2 8, 1 9, 4 -0.146 0.717 0.838 0.077 0.864 0.112 4.2 0.662 1.44 0.645 0.19 1.94 0.102 5200 1.05 2.26 0.641 0.193 2.86 0.0841 52800 1.42 1.91 0.457 0.34 4.15 0.152 1640 PRS_PLINK_1e.05 112.3 Candidiasis of skin and nails Both 0 4 1 infectious diseases blue 4, 0 1 1 1 1 PRS_PLINK_1e.05 117 Mycoses Both 2 4 1 infectious diseases blue 4, 2 1, 0 1, 0 1, 0 1, 2 -0.0683 1150 1 0 0.934 0.744 1.26 -0.362 3530 1 0 0.696 0.0423 2.15 PRS_PLINK_1e.05 117.4 Aspergillosis Both 2 1 1 infectious diseases blue 1, 2 -0.00298 799 1 0 0.997 0.977 1.03 PRS_PLINK_1e.05 130 Spirochetal infection Both 1 3 1 infectious diseases blue 3, 1 1, 0 1, 0 1, 1 1, 0 7.92 11000 0.999 0 2760 3.06e-09 6.56e+14 0.662 11400 1 0 1.94 0.255 3.82 PRS_PLINK_1e.05 130.1 Lyme disease Both 0 2 1 infectious diseases blue 2, 0 1 1 1 1 PRS_PLINK_1e.05 131 Protozoan infection Both 0 2 1 infectious diseases blue 2, 0 1 1 1 1 PRS_PLINK_1e.05 134 Helminthiases Both 1 1 1 infectious diseases blue 1, 1 -0.00863 21.4 1 0 0.991 0.967 1.04 PRS_PLINK_1e.05 134.1 Intestinal helminthiases Both 1 0 1 infectious diseases blue 0, 1 PRS_PLINK_1e.05 136 Other infectious and parasitic diseases Both 6 41 1 infectious diseases blue 41, 6 10, 2 10, 0 10, 1 10, 3 -0.18 0.564 0.75 0.125 0.836 0.238 3.03 -0.632 1.64 0.701 0.154 0.532 2.35e-06 18.3 0.163 1.35 0.904 0.044 1.18 0.0686 6750 -1.79 1.93 0.353 0.452 0.167 0.000304 5.14 PRS_PLINK_1e.05 145 Cancer of mouth Both 1 10 2 neoplasms darkcyan 10, 1 3, 0 2, 0 2, 0 3, 1 -0.0271 1.79 0.988 0.005 0.973 0.0176 32.3 0.197 3890 1 0 1.22 0.648 1.39 PRS_PLINK_1e.05 145.1 Cancer of lip Both 0 1 2 neoplasms darkcyan 1, 0 PRS_PLINK_1e.05 145.2 Cancer of tongue Both 0 2 2 neoplasms darkcyan 2, 0 1 1 1 1 PRS_PLINK_1e.05 145.3 Cancer of major salivary glands Both 1 2 2 neoplasms darkcyan 2, 1 1, 0 0, 1 1, 0 1, 0 0.432 16100 1 0 1.54 0.0134 2.57 -0.00124 9.03 1 0 0.999 0.979 1.02 PRS_PLINK_1e.05 145.4 Cancer of the gums Both 0 2 2 neoplasms darkcyan 2, 0 1 1 1 1 PRS_PLINK_1e.05 149 Cancer of larynx, pharynx, nasal cavities Both 1 10 2 neoplasms darkcyan 10, 1 3, 0 2, 0 2, 0 3, 1 0.0281 2.1 0.989 0.005 1.03 0.0172 112 0.168 3820 1 0 1.18 0.0464 38.5 PRS_PLINK_1e.05 149.1 Cancer of oropharynx Both 0 3 2 neoplasms darkcyan 3, 0 1 1 1 1 PRS_PLINK_1e.05 149.2 Cancer of nasopharynx Both 0 1 2 neoplasms darkcyan 1, 0 PRS_PLINK_1e.05 149.4 Cancer of larynx Both 0 3 2 neoplasms darkcyan 3, 0 1 1 1 1 PRS_PLINK_1e.05 149.5 Hx of malignant neoplasm of oral cavity and pharynx Both 1 3 2 neoplasms darkcyan 3, 1 1, 0 1, 0 1, 1 1, 0 -0.311 1910 1 0 0.733 0.152 1.19 -0.00764 41 1 0 0.992 0.928 1.07 PRS_PLINK_1e.05 149.9 Cancer of of nasal cavities Both 0 1 2 neoplasms darkcyan 1, 0 PRS_PLINK_1e.05 150 Cancer of esophagus Both 0 3 2 neoplasms darkcyan 3, 0 1 1 1 1 PRS_PLINK_1e.05 151 Cancer of stomach Both 1 1 2 neoplasms darkcyan 1, 1 -0.000406 14.6 1 0 1 0.992 1.01 PRS_PLINK_1e.05 153 Colorectal cancer Both 0 9 2 neoplasms darkcyan 9, 0 3 2 2 2 PRS_PLINK_1e.05 153.2 Colon cancer Both 0 6 2 neoplasms darkcyan 6, 0 2 1 1 2 PRS_PLINK_1e.05 153.3 Malignant neoplasm of rectum, rectosigmoid junction, and anus Both 0 3 2 neoplasms darkcyan 3, 0 1 1 1 1 PRS_PLINK_1e.05 155 Cancer of liver and intrahepatic bile duct Both 0 4 2 neoplasms darkcyan 4, 0 1 1 1 1 PRS_PLINK_1e.05 155.1 Malignant neoplasm of liver, primary Both 0 4 2 neoplasms darkcyan 4, 0 1 1 1 1 PRS_PLINK_1e.05 157 Pancreatic cancer Both 0 2 2 neoplasms darkcyan 2, 0 1 1 1 1 PRS_PLINK_1e.05 158 Neoplasm of unspecified nature of digestive system Both 2 10 2 neoplasms darkcyan 10, 2 3, 0 2, 0 2, 0 3, 2 -0.241 1.72 0.888 0.052 0.786 0.00814 10.9 -0.39 174 0.998 0.001 0.677 0.144 0.142 PRS_PLINK_1e.05 159 Malignant neoplasm of other and ill-defined sites within the digestive organs and peritoneum Both 1 9 2 neoplasms darkcyan 9, 1 3, 0 2, 0 2, 1 2, 0 -1.3 2.42 0.591 0.228 0.272 0.00508 6.79 0.0517 1610 1 0 1.05 0.72 1.58 PRS_PLINK_1e.05 159.2 Malignant neoplasm of small intestine, including duodenum Both 0 2 2 neoplasms darkcyan 2, 0 1 1 1 1 PRS_PLINK_1e.05 159.3 Malignant neoplasm of gallbladder and extrahepatic bile ducts Both 0 2 2 neoplasms darkcyan 2, 0 1 1 1 1 PRS_PLINK_1e.05 159.4 Malignant neoplasm of retroperitoneum and peritoneum Both 0 1 2 neoplasms darkcyan 1, 0 PRS_PLINK_1e.05 165 Cancer within the respiratory system Both 0 12 2 neoplasms darkcyan 12, 0 3 3 3 3 PRS_PLINK_1e.05 165.1 Cancer of bronchus; lung Both 0 10 2 neoplasms darkcyan 10, 0 3 2 2 3 PRS_PLINK_1e.05 170 Cancer of bone and connective tissue Both 0 15 2 neoplasms darkcyan 15, 0 4 4 3 4 PRS_PLINK_1e.05 170.1 Bone cancer Both 0 12 2 neoplasms darkcyan 12, 0 3 3 3 3 PRS_PLINK_1e.05 170.2 Cancer of connective tissue Both 0 5 2 neoplasms darkcyan 5, 0 2 1 1 1 PRS_PLINK_1e.05 172 Skin cancer Both 5 43 2 neoplasms darkcyan 43, 5 10, 1 11, 2 10, 0 11, 2 0.41 0.529 0.438 0.359 1.51 0.495 5.86 1 1.79 0.577 0.239 2.72 0.00735 19400 -0.556 1.31 0.671 0.173 0.573 0.0269 11.4 1.49 1.71 0.384 0.416 4.45 0.113 3690 PRS_PLINK_1e.05 172.1 Melanomas of skin, dx or hx Both 4 33 2 neoplasms darkcyan 33, 4 8, 0 8, 2 8, 0 8, 2 1.05 0.739 0.155 0.811 2.86 0.725 614 0.923 1.65 0.577 0.239 2.52 0.0359 408 -0.00649 1.66 0.997 0.001 0.994 0.00692 129 PRS_PLINK_1e.05 172.11 Melanomas of skin Both 1 19 2 neoplasms darkcyan 19, 1 5, 0 5, 0 4, 0 5, 1 0.144 0.837 0.863 0.064 1.16 0.0214 6.78 -0.0643 1.9 0.973 0.012 0.938 0.000446 47.2 PRS_PLINK_1e.05 172.2 Other non-epithelial cancer of skin Both 4 37 2 neoplasms darkcyan 37, 4 10, 1 9, 2 9, 0 9, 1 0.296 0.523 0.572 0.242 1.34 0.463 4.69 0.889 1.77 0.615 0.211 2.43 0.00385 15100 -0.404 1.32 0.76 0.119 0.667 0.0312 9.4 -0.0562 1.62 0.972 0.012 0.945 0.0138 267 PRS_PLINK_1e.05 172.21 Basal cell carcinoma Both 4 22 2 neoplasms darkcyan 22, 4 6, 1 5, 2 5, 0 6, 1 0.442 0.681 0.516 0.287 1.56 0.456 6.42 1.11 1.78 0.531 0.275 3.04 0.0219 574 -0.604 1.5 0.688 0.162 0.547 0.000661 14.4 3.45 4.11 0.402 0.396 31.4 0.0648 179000 PRS_PLINK_1e.05 172.22 Squamous cell carcinoma Both 0 12 2 neoplasms darkcyan 12, 0 3 3 3 3 PRS_PLINK_1e.05 172.3 Carcinoma in situ of skin Both 0 11 2 neoplasms darkcyan 11, 0 3 3 2 3 PRS_PLINK_1e.05 173 Neoplasm of uncertain behavior of skin Both 1 26 2 neoplasms darkcyan 26, 1 7, 0 6, 0 6, 0 7, 1 -0.123 0.824 0.882 0.055 0.885 0.0394 12.3 -0.774 3.23 0.811 0.091 0.461 2.12e-05 1120 PRS_PLINK_1e.05 174 Breast cancer Both 3 18 2 neoplasms darkcyan 18, 3 5, 3 4, 0 4, 0 5, 0 -0.426 0.866 0.623 0.206 0.653 0.00703 4.17 -0.774 2.03 0.702 0.153 0.461 0.00234 31.6 -2.67 3.54 0.45 0.347 0.0689 5.06e-06 31.8 0.973 3.15 0.758 0.12 2.64 0.000977 8550 PRS_PLINK_1e.05 174.1 Breast cancer [female] Female 3 19 2 neoplasms darkcyan 19, 3 5, 3 5, 0 4, 0 5, 0 -0.419 0.851 0.622 0.206 0.658 0.0512 4.15 -1.09 1.86 0.557 0.254 0.336 0.00206 5.82 -3.92 4.64 0.399 0.399 0.0199 2.93e-06 33.2 0.973 3.15 0.758 0.12 2.64 0.000977 8550 PRS_PLINK_1e.05 174.11 Malignant neoplasm of female breast Female 3 18 2 neoplasms darkcyan 18, 3 5, 3 4, 0 4, 0 5, 0 -0.426 0.866 0.623 0.206 0.653 0.00703 4.17 -0.774 2.03 0.702 0.153 0.461 0.00234 31.6 -2.67 3.54 0.45 0.347 0.0689 5.06e-06 31.8 0.973 3.15 0.758 0.12 2.64 0.000977 8550 PRS_PLINK_1e.05 174.3 Neoplasm of uncertain behavior of breast Both 0 2 2 neoplasms darkcyan 2, 0 1 1 1 1 PRS_PLINK_1e.05 175 Acquired absence of breast Female 1 5 2 neoplasms darkcyan 5, 1 2, 1 1, 0 1, 0 1, 0 -0.11 126 0.999 0 0.896 0.65 1.57 -0.192 3140 1 0 0.825 0.0294 2.29 0.168 2180 1 0 1.18 0.727 3.15 0.342 4130 1 0 1.41 0.74 5.38 PRS_PLINK_1e.05 180 Cervical cancer and dysplasia Female 2 11 2 neoplasms darkcyan 11, 2 3, 2 3, 0 2, 0 3, 0 -0.279 1.56 0.858 0.067 0.756 0.00209 191 0.0871 426 1 0 1.09 0.585 3.59 -0.0129 446 1 0 0.987 0.524 1.76 0.196 637 1 0 1.22 0.483 1.28 PRS_PLINK_1e.05 180.1 Cervical cancer Female 1 4 2 neoplasms darkcyan 4, 1 1, 1 1, 0 1, 0 1, 0 -0.117 4820 1 0 0.89 0.241 2.02 -14.1 265000 1 0 7.89e-07 1.03e-26 1.43e+10 -17.1 160000 1 0 3.65e-08 1.97e-29 7.02e+18 -8.13 74600 1 0 0.000294 6.3e-17 856000 PRS_PLINK_1e.05 180.3 Cervical intraepithelial neoplasia [CIN] [Cervical dysplasia] Female 1 11 2 neoplasms darkcyan 11, 1 3, 1 3, 0 2, 0 3, 0 0.174 1.7 0.918 0.037 1.19 0.00594 1710 -0.052 1470 1 0 0.949 0.335 2.48 -0.00856 561 1 0 0.991 0.675 1.22 -0.043 1400 1 0 0.958 0.43 2.04 PRS_PLINK_1e.05 182 Malignant neoplasm of uterus Female 0 5 2 neoplasms darkcyan 5, 0 2 1 1 1 PRS_PLINK_1e.05 184 Cancer of other female genital organs Female 0 6 2 neoplasms darkcyan 6, 0 2 1 1 2 PRS_PLINK_1e.05 184.1 Malignant neoplasm of ovary and other uterine adnexa Female 0 2 2 neoplasms darkcyan 2, 0 1 1 1 1 PRS_PLINK_1e.05 184.11 Malignant neoplasm of ovary Female 0 3 2 neoplasms darkcyan 3, 0 1 1 1 1 PRS_PLINK_1e.05 184.2 Cancer of other female genital organs (excluding uterus and ovary) Female 0 5 2 neoplasms darkcyan 5, 0 2 1 1 1 PRS_PLINK_1e.05 185 Cancer of prostate Male 0 9 2 neoplasms darkcyan 9, 0 3 2 2 2 PRS_PLINK_1e.05 187 Cancer of other male genital organs Male 1 2 2 neoplasms darkcyan 2, 1 1, 1 1, 1 1, 1 1, 1 0.0392 1970 1 0 1.04 0.904 1.07 PRS_PLINK_1e.05 187.2 Malignant neoplasm of testis Male 1 3 2 neoplasms darkcyan 3, 1 1, 0 1, 1 1, 0 1, 1 0.162 1080 1 0 1.18 0.825 2.49 PRS_PLINK_1e.05 187.8 Neoplasm of uncertain behavior of male genital organs Male 0 1 2 neoplasms darkcyan 1, 0 PRS_PLINK_1e.05 189 Cancer of urinary organs (incl. kidney and bladder) Both 0 19 2 neoplasms darkcyan 19, 0 5 5 4 5 PRS_PLINK_1e.05 189.1 Cancer of kidney and renal pelvis Both 0 10 2 neoplasms darkcyan 10, 0 3 2 2 3 PRS_PLINK_1e.05 189.11 Malignant neoplasm of kidney, except pelvis Both 0 9 2 neoplasms darkcyan 9, 0 3 2 2 2 PRS_PLINK_1e.05 189.12 Malignant neoplasm of renal pelvis Both 0 3 2 neoplasms darkcyan 3, 0 1 1 1 1 PRS_PLINK_1e.05 189.2 Cancer of bladder Both 0 10 2 neoplasms darkcyan 10, 0 3 2 2 3 PRS_PLINK_1e.05 189.21 Malignant neoplasm of bladder Both 0 8 2 neoplasms darkcyan 8, 0 2 2 2 2 PRS_PLINK_1e.05 189.4 Malignant neoplasm of other urinary organs Both 0 2 2 neoplasms darkcyan 2, 0 1 1 1 1 PRS_PLINK_1e.05 190 Cancer of eye Both 0 1 2 neoplasms darkcyan 1, 0 PRS_PLINK_1e.05 191 Manlignant and unknown neoplasms of brain and nervous system Both 0 10 2 neoplasms darkcyan 10, 0 3 2 2 3 PRS_PLINK_1e.05 191.1 Cancer of brain and nervous system Both 0 7 2 neoplasms darkcyan 7, 0 2 2 1 2 PRS_PLINK_1e.05 191.11 Cancer of brain Both 0 8 2 neoplasms darkcyan 8, 0 2 2 2 2 PRS_PLINK_1e.05 193 Thyroid cancer Both 0 16 2 neoplasms darkcyan 16, 0 4 4 4 4 PRS_PLINK_1e.05 194 Cancer of other endocrine glands Both 0 11 2 neoplasms darkcyan 11, 0 3 3 2 3 PRS_PLINK_1e.05 195 Cancer, suspected or other Both 9 48 2 neoplasms darkcyan 48, 9 11, 3 12, 2 12, 2 12, 2 0.25 0.411 0.544 0.265 1.28 0.583 3.04 0.547 1.57 0.727 0.139 1.73 0.045 1960 -0.419 1.17 0.72 0.143 0.658 7.84e-05 6.09 -0.306 1.47 0.836 0.078 0.737 0.00578 23.4 PRS_PLINK_1e.05 195.1 Malignant neoplasm, other Both 8 49 2 neoplasms darkcyan 49, 8 12, 3 12, 2 12, 1 12, 2 0.228 0.411 0.579 0.237 1.26 0.568 2.99 -0.192 1.32 0.884 0.053 0.826 0.0108 18.7 -0.291 1.19 0.808 0.093 0.747 0.00244 8.13 -0.367 1.49 0.805 0.094 0.693 0.00611 22.6 PRS_PLINK_1e.05 195.3 Malignant neoplasm of head, face, and neck Both 0 8 2 neoplasms darkcyan 8, 0 2 2 2 2 PRS_PLINK_1e.05 196 Radiotherapy Both 0 14 2 neoplasms darkcyan 14, 0 4 3 3 4 PRS_PLINK_1e.05 197 Chemotherapy Both 1 33 2 neoplasms darkcyan 33, 1 9, 0 8, 0 8, 0 8, 1 0.121 0.513 0.813 0.09 1.13 0.261 5.82 0.506 1.65 0.76 0.119 1.66 0.0723 230 PRS_PLINK_1e.05 198 Secondary malignant neoplasm Both 0 31 2 neoplasms darkcyan 31, 0 7 8 7 8 PRS_PLINK_1e.05 198.1 Secondary malignancy of lymph nodes Both 0 25 2 neoplasms darkcyan 25, 0 7 6 6 6 PRS_PLINK_1e.05 198.2 Secondary malignancy of respiratory organs Both 0 6 2 neoplasms darkcyan 6, 0 2 1 1 2 PRS_PLINK_1e.05 198.3 Secondary malignant neoplasm of digestive systems Both 0 5 2 neoplasms darkcyan 5, 0 2 1 1 1 PRS_PLINK_1e.05 198.4 Secondary malignant neoplasm of liver Both 0 6 2 neoplasms darkcyan 6, 0 2 1 1 2 PRS_PLINK_1e.05 198.5 Secondary malignancy of brain/spine Both 0 7 2 neoplasms darkcyan 7, 0 2 2 1 2 PRS_PLINK_1e.05 198.6 Secondary malignancy of bone Both 0 9 2 neoplasms darkcyan 9, 0 3 2 2 2 PRS_PLINK_1e.05 199 Neoplasm of uncertain behavior Both 4 48 2 neoplasms darkcyan 48, 4 11, 0 12, 1 12, 2 12, 1 -0.0013 0.615 0.998 0.001 0.999 0.106 6.06 -0.213 1.42 0.881 0.055 0.808 0.00726 105 0.568 1.23 0.643 0.192 1.77 0.0301 66.4 -0.53 1.77 0.765 0.116 0.588 0.000632 33.7 PRS_PLINK_1e.05 199.4 Neurofibromatosis Both 0 1 2 neoplasms darkcyan 1, 0 PRS_PLINK_1e.05 200 Myeloproliferative disease Both 0 13 2 neoplasms darkcyan 13, 0 4 3 3 3 PRS_PLINK_1e.05 200.1 Polycythemia vera Both 0 5 2 neoplasms darkcyan 5, 0 2 1 1 1 PRS_PLINK_1e.05 201 Hodgkin's disease Both 0 2 2 neoplasms darkcyan 2, 0 1 1 1 1 PRS_PLINK_1e.05 202 Cancer of other lymphoid, histiocytic tissue Both 1 15 2 neoplasms darkcyan 15, 1 4, 0 4, 1 3, 0 4, 0 1.62 2.7 0.548 0.261 5.04 0.0729 505000 7.13 10.8 0.507 0.295 1250 0.00206 2010 PRS_PLINK_1e.05 202.2 Non-Hodgkins lymphoma Both 1 14 2 neoplasms darkcyan 14, 1 4, 0 3, 1 3, 0 4, 0 0.193 1.39 0.89 0.051 1.21 0.0864 12200 2.18 28.6 0.939 0.027 8.87 9.56 2980 PRS_PLINK_1e.05 202.21 Nodular lymphoma Both 1 8 2 neoplasms darkcyan 8, 1 2, 0 2, 0 2, 1 2, 0 1.6 37.4 0.966 0.015 4.93 0.0126 1980 -0.0759 2430 1 0 0.927 0.374 2.21 PRS_PLINK_1e.05 202.22 Reticulosarcoma Both 0 3 2 neoplasms darkcyan 3, 0 1 1 1 1 PRS_PLINK_1e.05 202.24 Large cell lymphoma Both 0 1 2 neoplasms darkcyan 1, 0 PRS_PLINK_1e.05 204 Leukemia Both 1 10 2 neoplasms darkcyan 10, 1 3, 0 2, 0 2, 0 3, 1 0.861 2.73 0.753 0.123 2.36 1.5 3.76 0.0512 884 1 0 1.05 0.564 1.81 PRS_PLINK_1e.05 204.1 Lymphoid leukemia Both 0 5 2 neoplasms darkcyan 5, 0 2 1 1 1 PRS_PLINK_1e.05 204.11 Lymphoid leukemia, acute Both 0 3 2 neoplasms darkcyan 3, 0 1 1 1 1 PRS_PLINK_1e.05 204.12 Lymphoid leukemia, chronic Both 0 2 2 neoplasms darkcyan 2, 0 1 1 1 1 PRS_PLINK_1e.05 204.2 Myeloid leukemia Both 0 7 2 neoplasms darkcyan 7, 0 2 2 1 2 PRS_PLINK_1e.05 204.21 Myeloid leukemia, acute Both 0 4 2 neoplasms darkcyan 4, 0 1 1 1 1 PRS_PLINK_1e.05 204.4 Multiple myeloma Both 0 2 2 neoplasms darkcyan 2, 0 1 1 1 1 PRS_PLINK_1e.05 208 Benign neoplasm of colon Both 24 38 2 neoplasms darkcyan 38, 24 9, 3 9, 9 9, 9 10, 3 0.237 0.311 0.446 0.351 1.27 0.726 2.32 1.43 0.992 0.149 0.826 4.18 0.821 34.8 0.911 1.08 0.398 0.4 2.49 0.366 23.6 1.37 1.54 0.372 0.429 3.95 0.367 3.23e+10 PRS_PLINK_1e.05 209 Neuroendocrine tumors Both 1 3 2 neoplasms darkcyan 3, 1 1, 0 1, 0 1, 1 1, 0 0.693 31400 1 0 2 0.214 4.47 -0.00119 54.2 1 0 0.999 0.964 1.04 PRS_PLINK_1e.05 210 Benign neoplasm of lip, oral cavity, and pharynx Both 2 17 2 neoplasms darkcyan 17, 2 5, 1 4, 1 4, 0 4, 0 -0.0534 1.11 0.962 0.017 0.948 0.018 48.9 -1.91 4.55 0.675 0.171 0.148 7.66e-05 68.1 -1.62 39.2 0.967 0.015 0.198 0.00303 0.146 -0.737 7.98 0.926 0.033 0.478 4.37e-07 88800 PRS_PLINK_1e.05 211 Benign neoplasm of other parts of digestive system Both 19 43 2 neoplasms darkcyan 43, 19 10, 4 11, 3 10, 7 11, 5 0.142 0.324 0.661 0.18 1.15 0.634 2.14 -1.69 1.47 0.252 0.598 0.185 0.000897 2.76 0.699 0.886 0.43 0.366 2.01 0.432 10.9 -0.249 1.17 0.832 0.08 0.78 0.0882 6.55 PRS_PLINK_1e.05 212 Benign neoplasm of respiratory and intrathoracic organs Both 4 14 2 neoplasms darkcyan 14, 4 4, 1 3, 1 3, 0 4, 2 0.0585 1.09 0.957 0.019 1.06 0.373 7.55 -0.762 2.5 0.76 0.119 0.467 0.404 24.4 1.02 3920000 1 0 2.77 0.016 1160 -6.13 10.1 0.542 0.266 0.00218 7e-11 10900 PRS_PLINK_1e.05 213 Benign neoplasm of bone and articular cartilage Both 0 14 2 neoplasms darkcyan 14, 0 4 3 3 4 PRS_PLINK_1e.05 214 Lipoma Both 3 12 2 neoplasms darkcyan 12, 3 3, 1 3, 0 3, 1 3, 1 -0.0546 0.818 0.947 0.024 0.947 0.0369 5.27 0.118 1240 1 0 1.13 0.372 3.77 0.0491 1610 1 0 1.05 0.0159 58 0.347 9310 1 0 1.42 0.386 13.1 PRS_PLINK_1e.05 214.1 Lipoma of skin and subcutaneous tissue Both 1 6 2 neoplasms darkcyan 6, 1 2, 0 1, 0 1, 1 2, 0 0.000569 110 1 0 1 0.573 1.66 5.99e-06 4750 1 0 1 0.323 1.52 PRS_PLINK_1e.05 215 Other benign neoplasm of connective and other soft tissue Both 9 45 2 neoplasms darkcyan 45, 9 12, 2 11, 4 11, 1 11, 2 -0.253 0.528 0.631 0.2 0.776 0.242 2.23 2.99 1.98 0.13 0.886 19.9 0.691 168000 -0.221 1.34 0.869 0.061 0.802 0.00675 404 -2.68 2.47 0.278 0.556 0.0685 3.8e-07 7.26 PRS_PLINK_1e.05 216 Benign neoplasm of skin Both 20 44 2 neoplasms darkcyan 44, 20 10, 8 11, 3 11, 4 11, 5 -0.157 0.341 0.645 0.19 0.855 0.438 1.64 -0.97 1.05 0.356 0.448 0.379 0.0438 2.26 -1 0.945 0.289 0.539 0.367 0.0484 1.81 -0.179 0.943 0.85 0.071 0.836 0.156 4.57 PRS_PLINK_1e.05 216.1 Screening for malignant neoplasms of the skin Both 0 5 2 neoplasms darkcyan 5, 0 2 1 1 1 PRS_PLINK_1e.05 217 Vascular hamartomas and non-neoplastic nevi Both 1 16 2 neoplasms darkcyan 16, 1 4, 0 4, 1 4, 0 4, 0 0.135 0.933 0.885 0.053 1.14 0.134 37 0.0409 7950000 1 0 1.04 0.403 2.4 PRS_PLINK_1e.05 217.1 Nevus, non-neoplastic Both 1 15 2 neoplasms darkcyan 15, 1 4, 0 4, 1 3, 0 4, 0 0.0843 0.919 0.927 0.033 1.09 0.161 9.97 0.0409 7950000 1 0 1.04 0.403 2.4 PRS_PLINK_1e.05 218 Benign neoplasm of uterus Female 10 18 2 neoplasms darkcyan 18, 10 5, 2 4, 4 4, 0 5, 4 -0.373 0.589 0.527 0.279 0.688 0.221 1.91 1.35 1.65 0.413 0.384 3.86 0.29 138 -1.66 3.02 0.581 0.236 0.189 0.000498 20.7 -2.1 2.29 0.359 0.445 0.123 0.00115 4.2 PRS_PLINK_1e.05 218.1 Uterine leiomyoma Female 3 16 2 neoplasms darkcyan 16, 3 4, 1 4, 2 4, 0 4, 0 0.0694 0.748 0.926 0.033 1.07 0.29 4.14 2.33 2.25 0.301 0.521 10.2 0.515 12900 -1.13 46.1 0.98 0.009 0.322 0.00088 126 -2.83 12.4 0.819 0.087 0.0592 0.0504 0.0694 PRS_PLINK_1e.05 218.2 Other benign neoplasm of uterus Female 10 17 2 neoplasms darkcyan 17, 10 5, 1 4, 5 4, 0 4, 4 -0.404 0.601 0.501 0.3 0.667 0.212 1.88 1.6 1.79 0.373 0.429 4.94 0.303 250 -2.09 3.92 0.593 0.227 0.123 1.64e-05 38.9 -1.16 2.78 0.677 0.169 0.315 0.00212 23.1 PRS_PLINK_1e.05 220 Benign neoplasm of ovary Female 1 8 2 neoplasms darkcyan 8, 1 2, 0 2, 0 2, 0 2, 1 1.04 6.22 0.867 0.062 2.84 2.67 3.03 0.0732 3830 1 0 1.08 0.534 1.38 PRS_PLINK_1e.05 221 Benign neoplasm of other female genital organs Female 5 13 2 neoplasms darkcyan 13, 5 4, 2 3, 1 3, 0 3, 2 -0.136 1 0.892 0.05 0.873 0.154 9.75 -1.19 9.04 0.895 0.048 0.304 0.282 0.328 -2.13 4.74 0.652 0.186 0.118 0.104 18.1 -1.57 3 0.601 0.221 0.209 9.09e-05 12.7 PRS_PLINK_1e.05 222 Benign neoplasm of male genital organs Male 1 8 2 neoplasms darkcyan 8, 1 1, 0 2, 0 2, 0 2, 1 0.46 28.3 0.987 0.006 1.58 3.08 3.19 -0.0614 3160 1 0 0.94 0.884 1.2 PRS_PLINK_1e.05 223 Benign neoplasm of kidney and other urinary organs Both 2 7 2 neoplasms darkcyan 7, 2 2, 0 2, 0 1, 1 2, 0 0.174 17 0.992 0.004 1.19 0.827 0.808 0.118 3760 1 0 1.12 0.775 1.73 PRS_PLINK_1e.05 224 Benign neoplasm of eye Both 2 8 2 neoplasms darkcyan 8, 2 2, 2 2, 0 2, 0 2, 0 -0.334 11.4 0.977 0.01 0.716 0.458 0.678 0.174 3190 1 0 1.19 0.582 5.24 0.0811 1290 1 0 1.08 0.569 5.67 0.00968 1430 1 0 1.01 0.675 1.15 PRS_PLINK_1e.05 224.1 Benign neoplasm of eye, uveal Both 2 10 2 neoplasms darkcyan 10, 2 3, 2 2, 0 2, 0 3, 0 -0.513 3.09 0.868 0.061 0.598 3.84e-06 80.6 0.171 925 1 0 1.19 0.572 4.03 0.311 1180 1 0 1.37 0.621 4.46 -0.0762 911 1 0 0.927 0.258 1.76 PRS_PLINK_1e.05 225 Benign neoplasm of brain and other parts of nervous system Both 0 13 2 neoplasms darkcyan 13, 0 4 3 3 3 PRS_PLINK_1e.05 225.1 Benign neoplasm of brain, cranial nerves, meninges Both 0 11 2 neoplasms darkcyan 11, 0 3 3 2 3 PRS_PLINK_1e.05 225.2 Benign neoplasm of spinal cord, meninges Both 0 3 2 neoplasms darkcyan 3, 0 1 1 1 1 PRS_PLINK_1e.05 226 Benign neoplasm of thyroid glands Both 0 14 2 neoplasms darkcyan 14, 0 4 3 3 4 PRS_PLINK_1e.05 227 Benign neoplasm of other endocrine glands and related structures Both 0 16 2 neoplasms darkcyan 16, 0 4 4 4 4 PRS_PLINK_1e.05 227.1 Benign neoplasm of adrenal gland Both 0 5 2 neoplasms darkcyan 5, 0 2 1 1 1 PRS_PLINK_1e.05 227.2 Benign neoplasm of parathyroid gland Both 0 7 2 neoplasms darkcyan 7, 0 2 2 1 2 PRS_PLINK_1e.05 227.3 Benign neoplasm of pituitary gland and craniopharyngeal duct (pouch) Both 0 4 2 neoplasms darkcyan 4, 0 1 1 1 1 PRS_PLINK_1e.05 228 Hemangioma and lymphangioma, any site Both 1 28 2 neoplasms darkcyan 28, 1 7, 0 7, 1 7, 0 7, 0 0.171 0.817 0.834 0.079 1.19 0.0506 53.6 -0.345 2.91 0.906 0.043 0.708 4.96e-05 1300 PRS_PLINK_1e.05 228.1 Hemangioma of skin and subcutaneous tissue Both 1 16 2 neoplasms darkcyan 16, 1 4, 0 4, 1 4, 0 4, 0 0.173 0.998 0.862 0.064 1.19 0.174 46.9 -0.171 169 0.999 0 0.843 0.373 1.12 PRS_PLINK_1e.05 229 Benign neoplasm of unspecified sites Both 4 45 2 neoplasms darkcyan 45, 4 12, 1 11, 1 11, 1 11, 1 0.142 0.772 0.854 0.069 1.15 0.0733 47.5 -0.39 1.58 0.805 0.094 0.677 0.00141 189 -0.529 1.3 0.685 0.164 0.589 0.0183 10.3 0.527 1.75 0.763 0.117 1.69 0.0385 602 PRS_PLINK_1e.05 229.1 Benign neoplasm of lymph nodes Both 1 30 2 neoplasms darkcyan 30, 1 8, 1 7, 0 7, 0 8, 0 -0.184 0.604 0.761 0.119 0.832 0.0462 3.88 -0.7 1.73 0.686 0.164 0.496 0.0117 8.75 -0.321 1.57 0.838 0.077 0.726 0.0174 28 0.0755 1.71 0.965 0.016 1.08 0.0357 458 PRS_PLINK_1e.05 240 Simple and unspecified goiter Both 2 15 3 endocrine/metabolic brown 15, 2 4, 1 4, 1 3, 0 4, 0 -0.261 1.22 0.831 0.08 0.771 0.0175 17.8 -1.04 581 0.999 0.001 0.352 0.0123 5.25 0.141 200 0.999 0 1.15 1.12 4.58 -0.0512 596 1 0 0.95 0.559 1.36 PRS_PLINK_1e.05 241 Nontoxic nodular goiter Both 1 31 3 endocrine/metabolic brown 31, 1 8, 1 8, 0 7, 0 8, 0 -0.578 0.828 0.485 0.314 0.561 0.033 3.98 -1.1 1.86 0.554 0.256 0.333 0.000471 19.6 -0.615 2.69 0.819 0.087 0.541 0.000262 98 -1.12 2.65 0.674 0.172 0.328 0.000807 216 PRS_PLINK_1e.05 241.1 Nontoxic uninodular goiter Both 0 30 3 endocrine/metabolic brown 30, 0 8 7 7 8 PRS_PLINK_1e.05 241.2 Nontoxic multinodular goiter Both 0 16 3 endocrine/metabolic brown 16, 0 4 4 4 4 PRS_PLINK_1e.05 242 Thyrotoxicosis with or without goiter Both 2 20 3 endocrine/metabolic brown 20, 2 5, 2 5, 0 5, 0 5, 0 -0.536 1.29 0.677 0.169 0.585 0.0134 16.7 -0.581 2.19 0.791 0.102 0.559 0.00039 911 -0.651 5.25 0.901 0.045 0.522 2.71e-06 2500 -2.67 3.68 0.468 0.33 0.0689 0.000143 29.2 PRS_PLINK_1e.05 242.1 Graves' disease Both 1 9 3 endocrine/metabolic brown 9, 1 3, 1 2, 0 2, 0 2, 0 0.0152 425 1 0 1.02 0.866 1.37 -0.00573 825 1 0 0.994 0.766 1.21 0.0237 1160 1 0 1.02 0.683 1.3 -0.0532 7100 1 0 0.948 0.129 6.16 PRS_PLINK_1e.05 242.2 Toxic multinodular goiter Both 0 2 3 endocrine/metabolic brown 2, 0 1 1 1 1 PRS_PLINK_1e.05 242.3 Exophthalmos Both 2 5 3 endocrine/metabolic brown 5, 2 2, 2 1, 0 1, 0 1, 0 -0.0859 1370 1 0 0.918 0.81 1.3 -0.0906 16900 1 0 0.913 0.0935 19.9 -0.0225 3860 1 0 0.978 0.76 1.99 -0.481 7830 1 0 0.618 0.498 2.53 PRS_PLINK_1e.05 242.31 Thyrotoxic exophthalmos Both 1 2 3 endocrine/metabolic brown 2, 1 1, 1 1, 0 1, 1 1, 0 -0.1 4900 1 0 0.905 0.396 1.87 8.25 746000 1 0 3810 1.37e-10 4.19e+16 PRS_PLINK_1e.05 244 Hypothyroidism Both 11 44 3 endocrine/metabolic brown 44, 11 11, 7 11, 3 11, 0 11, 1 -1.25 0.565 0.0271 1.566 0.287 0.0668 0.753 -2 1.3 0.124 0.907 0.136 0.00368 1.24 -4.74 2.54 0.0621 1.207 0.00873 1.53e-07 0.379 -1.21 1.41 0.389 0.41 0.297 0.000146 3.3 PRS_PLINK_1e.05 244.1 Secondary hypothyroidism Both 2 28 3 endocrine/metabolic brown 28, 2 7, 2 7, 0 7, 0 7, 0 -0.452 1.01 0.654 0.185 0.636 0.037 9.35 -0.325 1.81 0.857 0.067 0.723 0.0191 64.4 -0.735 1.84 0.689 0.162 0.48 0.0112 46 0.624 2.63 0.813 0.09 1.87 0.00031 739 PRS_PLINK_1e.05 244.2 Acquired hypothyroidism Both 5 21 3 endocrine/metabolic brown 21, 5 6, 4 5, 0 5, 0 5, 1 -0.962 0.707 0.173 0.761 0.382 0.0753 1.19 -2.36 1.9 0.214 0.67 0.0941 0.000526 1.46 -2.52 2.12 0.236 0.627 0.0808 0.000301 1.83 -2.37 3.08 0.442 0.355 0.0937 1.52e-05 3650 PRS_PLINK_1e.05 244.4 Hypothyroidism NOS Both 10 44 3 endocrine/metabolic brown 44, 10 11, 6 11, 3 11, 0 11, 1 -1.17 0.577 0.0424 1.373 0.31 0.0631 0.832 -1.57 1.31 0.233 0.632 0.209 0.00582 2.09 -3.6 2.07 0.0813 1.09 0.0272 5.91e-08 0.599 -0.744 1.39 0.593 0.227 0.475 0.00141 5.81 PRS_PLINK_1e.05 245 Thyroiditis Both 1 16 3 endocrine/metabolic brown 16, 1 4, 1 4, 0 4, 0 4, 0 -0.898 1.22 0.46 0.337 0.407 0.012 2.9 -4.52 221 0.984 0.007 0.0109 1.65e-13 3000 -2.02 20500000 1 0 0.133 1.1e-06 365000 -3.13 54.9 0.955 0.02 0.0439 2.01e-07 0.0715 PRS_PLINK_1e.05 245.2 Chronic thyroiditis Both 1 14 3 endocrine/metabolic brown 14, 1 4, 1 3, 0 3, 0 4, 0 -0.994 1.33 0.455 0.342 0.37 0.0102 2.59 -2.23 2860 0.999 0 0.108 0.00356 216 -4.91 4380000 1 0 0.0074 9.54e-06 0.351 -3.13 54.9 0.955 0.02 0.0439 2.01e-07 0.0715 PRS_PLINK_1e.05 245.21 Chronic lymphocytic thyroiditis Both 1 13 3 endocrine/metabolic brown 13, 1 4, 1 3, 0 3, 0 3, 0 -0.983 1.32 0.458 0.339 0.374 0.0177 2.56 -1.12 13800000 1 0 0.326 0.0142 8.16 -0.054 1090 1 0 0.947 0.238 0.0569 -2.24 1880 0.999 0 0.106 0.00593 0.0767 PRS_PLINK_1e.05 246 Other disorders of thyroid Both 8 40 3 endocrine/metabolic brown 40, 8 10, 3 10, 5 10, 0 10, 0 -1.19 0.733 0.105 0.978 0.305 0.0347 1.17 -1.43 1.43 0.316 0.5 0.239 0.00308 2.6 -2.38 1.94 0.22 0.657 0.0927 3.76e-08 3.6 -1.7 2 0.397 0.401 0.183 2.73e-06 360 PRS_PLINK_1e.05 246.2 Thyroid cyst Both 0 2 3 endocrine/metabolic brown 2, 0 1 1 1 1 PRS_PLINK_1e.05 246.7 Abnormal results of function study of thyroid Both 1 16 3 endocrine/metabolic brown 16, 1 4, 1 4, 0 4, 0 4, 0 -0.94 1.26 0.456 0.341 0.391 0.013 4.06 -0.0879 131 0.999 0 0.916 0.951 0.789 0.824 129 0.995 0.002 2.28 1.91e-06 635000 -1.02 6300000 1 0 0.361 0.000116 1.64 PRS_PLINK_1e.05 249 Secondary diabetes mellitus Both 7 5 3 endocrine/metabolic brown 5, 7 2, 0 1, 2 1, 1 1, 4 -0.0222 1.14 0.985 0.007 0.978 0.0192 8.97 -0.00109 63.3 1 0 0.999 0.923 1.12 4.23 7000 1 0 68.6 0.00292 84800000 -0.188 761 1 0 0.829 0.813 1.76 PRS_PLINK_1e.05 250 Diabetes mellitus Both 32 29 3 endocrine/metabolic brown 29, 32 8, 11 7, 5 7, 10 7, 5 -1.36 0.614 0.0264 1.578 0.256 0.0353 0.739 -1.23 1.36 0.366 0.436 0.292 0.00281 3.28 -0.163 1.23 0.895 0.048 0.85 0.0471 19 -1.59 1.35 0.239 0.622 0.203 0.0018 2.39 PRS_PLINK_1e.05 250.1 Type 1 diabetes Both 29 8 3 endocrine/metabolic brown 8, 29 2, 10 2, 3 2, 4 2, 11 -0.526 0.735 0.474 0.324 0.591 0.0744 2.32 -0.0444 2.29 0.984 0.007 0.957 0.000249 552 -0.856 2.06 0.679 0.168 0.425 0.000637 141 -0.186 1.48 0.9 0.046 0.83 0.00513 36.3 PRS_PLINK_1e.05 250.11 Type 1 diabetes with ketoacidosis Both 6 1 3 endocrine/metabolic brown 1, 6 0.172 2000 1 0 1.19 1.05 2.99 PRS_PLINK_1e.05 250.12 Type 1 diabetes with renal manifestations Both 17 3 3 endocrine/metabolic brown 3, 17 1, 5 1, 2 1, 9 1, 5 -0.468 1.12 0.677 0.169 0.626 0.0236 43.7 0.484 15200000 1 0 1.62 0.0117 701 0.0263 1.76 0.988 0.005 1.03 0.0162 37.8 PRS_PLINK_1e.05 250.13 Type 1 diabetes with ophthalmic manifestations Both 21 4 3 endocrine/metabolic brown 4, 21 1, 9 1, 1 1, 1 1, 10 -0.425 0.84 0.613 0.213 0.654 0.0252 19.7 -0.52 1520 1 0 0.594 5.53e-11 8.27e+16 -0.287 6470 1 0 0.75 0.0549 8.11 -0.616 1.67 0.712 0.147 0.54 0.00259 69.7 PRS_PLINK_1e.05 250.14 Type 1 diabetes with neurological manifestations Both 22 4 3 endocrine/metabolic brown 4, 22 1, 9 1, 2 1, 0 1, 11 -0.551 1.1 0.615 0.211 0.576 0.0185 12.6 -2.58 8.29 0.755 0.122 0.0754 0.0639 0.0888 0.513 17 0.976 0.011 1.67 8.43e-08 2.4e+07 -0.246 1.81 0.892 0.05 0.782 0.00337 72.5 PRS_PLINK_1e.05 250.15 Diabetes type 1 with peripheral circulatory disorders Both 4 1 3 endocrine/metabolic brown 1, 4 0.235 13200000 1 0 1.27 0.232 3.1 PRS_PLINK_1e.05 250.2 Type 2 diabetes Both 30 26 3 endocrine/metabolic brown 26, 30 7, 10 6, 4 6, 10 7, 5 -1.13 0.573 0.0494 1.306 0.324 0.0547 0.886 -0.306 1.53 0.842 0.075 0.737 0.00503 37.3 -0.202 1.12 0.857 0.067 0.817 0.0407 8.02 -1.17 1.39 0.398 0.401 0.309 0.0038 7.64 PRS_PLINK_1e.05 250.21 Type 2 diabetes with ketoacidosis Both 6 0 3 endocrine/metabolic brown 0, 6 PRS_PLINK_1e.05 250.22 Type 2 diabetes with renal manifestations Both 4 6 3 endocrine/metabolic brown 6, 4 2, 0 1, 2 1, 0 2, 2 -4.77e-14 2.51 1 0 1 0.0246 41 -0.014 2710 1 0 0.986 0.533 1.72 -2.56e-06 1500 1 0 1 0.367 2.84 PRS_PLINK_1e.05 250.23 Type 2 diabetes with ophthalmic manifestations Both 19 7 3 endocrine/metabolic brown 7, 19 2, 5 2, 0 1, 1 2, 13 -0.653 0.985 0.507 0.295 0.52 0.0386 6.05 -2.24 77.8 0.977 0.01 0.106 3.07e-05 367 -2.95 12.9 0.819 0.087 0.0521 0.000449 0.0236 -0.833 1.63 0.609 0.215 0.435 0.00209 17.2 PRS_PLINK_1e.05 250.24 Type 2 diabetes with neurological manifestations Both 18 10 3 endocrine/metabolic brown 10, 18 3, 9 2, 0 2, 4 3, 5 0.0734 0.808 0.928 0.033 1.08 0.0834 9.58 -0.819 3.48 0.814 0.089 0.441 0.000948 294 -0.191 1.92 0.921 0.036 0.826 0.00344 64.1 -0.0895 1.75 0.959 0.018 0.914 0.00327 44 PRS_PLINK_1e.05 250.25 Diabetes type 2 with peripheral circulatory disorders Both 2 3 3 endocrine/metabolic brown 3, 2 1, 0 1, 0 0, 1 1, 1 0.0746 11100 1 0 1.08 0.0854 15 -0.00316 64.7 1 0 0.997 0.953 1.1 -0.0275 249 1 0 0.973 0.713 1.17 PRS_PLINK_1e.05 250.3 Insulin pump user Both 21 13 3 endocrine/metabolic brown 13, 21 4, 5 3, 4 3, 3 3, 8 -0.602 0.561 0.283 0.548 0.548 0.138 1.47 -0.127 1.69 0.94 0.027 0.88 0.000112 48 -0.198 1.47 0.893 0.049 0.82 0.0442 594 -0.224 1.48 0.879 0.056 0.799 0.0225 148 PRS_PLINK_1e.05 250.4 Abnormal glucose Both 29 27 3 endocrine/metabolic brown 27, 29 7, 10 7, 4 6, 9 7, 6 -0.871 0.618 0.159 0.798 0.419 0.03 1.32 -1.17 1.31 0.369 0.432 0.309 0.00108 2.94 -0.461 1.38 0.737 0.132 0.631 0.0102 27.1 -1.14 1.38 0.409 0.389 0.319 0.00934 4.43 PRS_PLINK_1e.05 250.41 Impaired fasting glucose Both 8 15 3 endocrine/metabolic brown 15, 8 4, 2 4, 1 3, 0 4, 5 -0.573 0.797 0.472 0.326 0.564 0.0768 3.07 -4.81 83.7 0.954 0.02 0.00811 8.8e-16 7.59e+10 -0.251 23.7 0.992 0.004 0.778 0.00103 700 -1.32 2.91 0.65 0.187 0.268 6.67e-05 29.4 PRS_PLINK_1e.05 250.42 Other abnormal glucose Both 29 27 3 endocrine/metabolic brown 27, 29 7, 10 7, 4 6, 9 7, 6 -0.871 0.618 0.159 0.798 0.419 0.03 1.32 -1.17 1.31 0.369 0.432 0.309 0.00108 2.94 -0.461 1.38 0.737 0.132 0.631 0.0102 27.1 -1.14 1.38 0.409 0.389 0.319 0.00934 4.43 PRS_PLINK_1e.05 250.6 Polyneuropathy in diabetes Both 22 7 3 endocrine/metabolic brown 7, 22 2, 8 2, 3 1, 9 2, 2 -0.236 0.702 0.737 0.132 0.79 0.0494 10.6 -0.401 1.87 0.831 0.081 0.67 0.00229 36.6 -0.00053 1.89 1 0 0.999 0.000622 153 -0.259 1.79 0.885 0.053 0.772 0.0174 28.1 PRS_PLINK_1e.05 250.7 Diabetic retinopathy Both 21 10 3 endocrine/metabolic brown 10, 21 3, 7 2, 1 2, 3 3, 10 -0.0729 0.581 0.9 0.046 0.93 0.331 2.6 -0.77 3.2 0.81 0.092 0.463 9e-04 366 -2.21 2.48 0.373 0.428 0.11 0.000729 64.8 -0.438 1.22 0.719 0.143 0.645 0.0705 4.88 PRS_PLINK_1e.05 251 Other disorders of pancreatic internal secretion Both 10 16 3 endocrine/metabolic brown 16, 10 4, 7 4, 0 4, 2 4, 1 -0.582 0.634 0.359 0.445 0.559 0.123 1.6 3.41 5.61 0.542 0.266 30.4 0.000473 1490000 1.56 2.38 0.513 0.29 4.76 0.154 64300 -0.402 1.8 0.823 0.084 0.669 0.017 19.8 PRS_PLINK_1e.05 251.1 Hypoglycemia Both 11 5 3 endocrine/metabolic brown 5, 11 2, 9 1, 0 1, 0 1, 2 -0.562 0.949 0.554 0.257 0.57 0.0562 2.67 -2.16 3.69 0.558 0.254 0.115 0.00019 16.4 -1.56 4.55 0.732 0.135 0.211 0.000154 1790 -0.787 1.9 0.679 0.168 0.455 0.0178 24.4 PRS_PLINK_1e.05 252 Disorders of parathyroid gland Both 2 21 3 endocrine/metabolic brown 21, 2 6, 1 5, 0 5, 0 5, 1 -0.179 0.995 0.858 0.067 0.836 0.0401 57.4 -0.278 2.71 0.918 0.037 0.757 0.00192 743 0.0309 5.36 0.995 0.002 1.03 2.27e-06 59600 -0.00666 1.94 0.997 0.001 0.993 0.0134 49.3 PRS_PLINK_1e.05 252.1 Hyperparathyroidism Both 2 21 3 endocrine/metabolic brown 21, 2 6, 1 5, 0 5, 0 5, 1 -0.179 0.995 0.858 0.067 0.836 0.0401 57.4 -0.278 2.71 0.918 0.037 0.757 0.00192 743 0.0309 5.36 0.995 0.002 1.03 2.27e-06 59600 -0.00666 1.94 0.997 0.001 0.993 0.0134 49.3 PRS_PLINK_1e.05 252.2 Hypoparathyroidism Both 0 5 3 endocrine/metabolic brown 5, 0 2 1 1 1 PRS_PLINK_1e.05 253 Disorders of the pituitary gland and its hypothalamic control Both 2 14 3 endocrine/metabolic brown 14, 2 4, 1 3, 1 3, 0 4, 0 0.513 1.24 0.678 0.169 1.67 0.191 75.6 0.0957 40.9 0.998 0.001 1.1 0.0181 1.6 -0.0245 2600 1 0 0.976 0.869 2.25 -0.224 35.2 0.995 0.002 0.799 5.55e-06 130000 PRS_PLINK_1e.05 253.1 Pituitary hyperfunction Both 0 6 3 endocrine/metabolic brown 6, 0 2 1 1 2 PRS_PLINK_1e.05 253.11 Acromegaly and gigantism Both 0 1 3 endocrine/metabolic brown 1, 0 PRS_PLINK_1e.05 253.2 Pituitary hypofunction Both 1 7 3 endocrine/metabolic brown 7, 1 2, 1 2, 0 1, 0 2, 0 -0.0486 433 1 0 0.953 0.648 1.15 -0.298 6900 1 0 0.742 0.0365 2.38 -0.334 8010 1 0 0.716 0.0134 2.48 -0.118 871 1 0 0.889 0.267 1.57 PRS_PLINK_1e.05 253.3 Diabetes insipidus Both 0 3 3 endocrine/metabolic brown 3, 0 1 1 1 1 PRS_PLINK_1e.05 253.4 Anterior pituitary disorders Both 0 4 3 endocrine/metabolic brown 4, 0 1 1 1 1 PRS_PLINK_1e.05 253.7 Other disorders of neurohypophysis Both 0 2 3 endocrine/metabolic brown 2, 0 1 1 1 1 PRS_PLINK_1e.05 255 Disorders of adrenal glands Both 0 20 3 endocrine/metabolic brown 20, 0 5 5 5 5 PRS_PLINK_1e.05 255.1 Adrenal hyperfunction Both 0 3 3 endocrine/metabolic brown 3, 0 1 1 1 1 PRS_PLINK_1e.05 255.11 Cushing's syndrome Both 0 1 3 endocrine/metabolic brown 1, 0 PRS_PLINK_1e.05 255.12 Hyperaldosteronism Both 0 1 3 endocrine/metabolic brown 1, 0 PRS_PLINK_1e.05 255.2 Adrenal hypofunction Both 0 7 3 endocrine/metabolic brown 7, 0 2 2 1 2 PRS_PLINK_1e.05 255.21 Glucocorticoid deficiency Both 0 7 3 endocrine/metabolic brown 7, 0 2 2 1 2 PRS_PLINK_1e.05 256 Ovarian dysfunction Female 2 11 3 endocrine/metabolic brown 11, 2 3, 1 3, 0 2, 0 3, 1 -0.0195 0.982 0.984 0.007 0.981 0.2 31.5 -0.0705 627 1 0 0.932 0.262 3.03 0.0261 2110 1 0 1.03 0.386 3.4 0.155 48.1 0.997 0.001 1.17 30.8 76.3 PRS_PLINK_1e.05 256.4 Polycystic ovaries Female 1 6 3 endocrine/metabolic brown 6, 1 2, 0 1, 0 1, 1 2, 0 0.468 5890 1 0 1.6 0.136 0.784 -2.24 2.97e+08 1 0 0.106 2.17e-06 18600 PRS_PLINK_1e.05 257 Testicular dysfunction Male 5 10 3 endocrine/metabolic brown 10, 5 3, 4 2, 1 2, 0 3, 0 -1.67 1.63 0.305 0.515 0.188 0.00321 2.67 3.77 8.63 0.662 0.179 43.4 0.000219 57.4 -0.103 7.91 0.99 0.005 0.902 0.0374 19.6 -0.991 2.73 0.717 0.145 0.371 0.000201 14.5 PRS_PLINK_1e.05 257.1 Testicular hypofunction Male 5 11 3 endocrine/metabolic brown 11, 5 3, 4 3, 1 2, 0 3, 0 -1.7 1.66 0.307 0.512 0.184 0.000483 2.29 2.89 10.2 0.777 0.109 17.9 1.48e-05 6.45e+09 -0.702 19.5 0.971 0.013 0.496 6.12e-10 1.21e+08 -2.25 3.01 0.454 0.342 0.105 8.59e-05 5.74 PRS_PLINK_1e.05 258 Iatrogenic endocrine disorders Both 0 1 3 endocrine/metabolic brown 1, 0 PRS_PLINK_1e.05 259 Other endocrine disorders Both 2 15 3 endocrine/metabolic brown 15, 2 4, 1 4, 1 3, 0 4, 0 -0.804 0.885 0.364 0.439 0.448 0.0451 1.78 -0.000993 2490000 1 0 0.999 0.502 2.68 -0.517 12500 1 0 0.596 0.44 19.6 -0.254 24 0.992 0.004 0.776 0.222 0.498 PRS_PLINK_1e.05 260 Protein-calorie malnutrition Both 2 22 3 endocrine/metabolic brown 22, 2 6, 0 5, 0 5, 1 6, 1 0.495 0.729 0.497 0.304 1.64 0.302 19.3 0.741 3.16 0.815 0.089 2.1 0.0153 663 0.982 2.2 0.656 0.183 2.67 0.0709 310 PRS_PLINK_1e.05 260.2 severe protein-calorie malnutrition Both 1 12 3 endocrine/metabolic brown 12, 1 3, 0 3, 0 3, 0 3, 1 0.381 0.81 0.638 0.195 1.46 0.361 8.7 0.0744 1180 1 0 1.08 0.64 3.09 PRS_PLINK_1e.05 260.22 Nutritional marasmus Both 1 4 3 endocrine/metabolic brown 4, 1 1, 0 1, 0 1, 0 1, 1 -0.0358 63.3 1 0 0.965 0.388 1.46 0.000653 159 1 0 1 0.969 1.02 PRS_PLINK_1e.05 260.3 Adult failure to thrive Both 1 3 3 endocrine/metabolic brown 3, 1 1, 0 1, 0 1, 1 1, 0 -0.0121 550 1 0 0.988 0.765 1.18 0.199 3600 1 0 1.22 0.626 1.36 PRS_PLINK_1e.05 260.6 Anorexia Both 1 4 3 endocrine/metabolic brown 4, 1 1, 0 1, 0 1, 1 1, 0 3.87 13300 1 0 47.7 0.000594 82600000 0.00416 31.9 1 0 1 0.98 1.03 PRS_PLINK_1e.05 260.7 Polyphagia Both 0 2 3 endocrine/metabolic brown 2, 0 1 1 1 1 PRS_PLINK_1e.05 261 Vitamin deficiency Both 20 37 3 endocrine/metabolic brown 37, 20 10, 5 9, 3 9, 8 9, 3 -0.238 0.309 0.441 0.355 0.788 0.44 1.38 -0.86 1.18 0.466 0.332 0.423 0.0302 3.32 0.586 0.891 0.511 0.292 1.8 0.39 9.28 -0.314 1.11 0.777 0.11 0.731 0.0895 4.92 PRS_PLINK_1e.05 261.1 Vitamin A deficiency Both 2 0 3 endocrine/metabolic brown 0, 2 PRS_PLINK_1e.05 261.2 Vitamin B-complex deficiencies Both 1 7 3 endocrine/metabolic brown 7, 1 2, 0 2, 0 1, 1 2, 0 -0.309 39.8 0.994 0.003 0.734 0.0186 31.6 -0.0128 47.4 1 0 0.987 0.677 1.11 PRS_PLINK_1e.05 261.4 Vitamin D deficiency Both 20 36 3 endocrine/metabolic brown 36, 20 9, 5 9, 3 9, 8 9, 3 -0.212 0.308 0.491 0.309 0.809 0.453 1.41 -0.847 1.21 0.483 0.316 0.429 0.0331 3.63 0.174 0.844 0.837 0.077 1.19 0.273 5.39 -0.449 1.11 0.687 0.163 0.638 0.0765 4.26 PRS_PLINK_1e.05 262 Mineral deficiency NEC Both 7 13 3 endocrine/metabolic brown 13, 7 4, 3 3, 1 3, 1 3, 2 -0.741 1.49 0.62 0.208 0.477 0.01 6.98 0.161 2.35 0.945 0.024 1.17 1.12 1.22 -0.16 3.01 0.958 0.019 0.852 0.00502 260 -0.799 4.48 0.858 0.066 0.45 0.000198 1470 PRS_PLINK_1e.05 263 Other nutritional deficiency Both 4 19 3 endocrine/metabolic brown 19, 4 5, 1 5, 0 4, 2 5, 1 -0.165 0.909 0.856 0.068 0.848 0.111 5.07 -1.71e-12 18.7 1 0 1 1.77e-12 1.65e+11 0.525 2.02 0.794 0.1 1.69 0.0593 253 0.0651 2.02 0.974 0.011 1.07 0.000449 86.9 PRS_PLINK_1e.05 264 Lack of normal physiological development Both 1 2 3 endocrine/metabolic brown 2, 1 1, 0 1, 1 1, 0 1, 1 -0.000977 152 1 0 0.999 0.979 1.03 0.000173 76.9 1 0 1 0.996 1.01 PRS_PLINK_1e.05 264.2 Failure to thrive (childhood) Both 1 4 3 endocrine/metabolic brown 4, 1 1, 0 1, 0 1, 0 1, 1 -0.269 6620 1 0 0.764 0.0543 2.79 -0.00087 19.8 1 0 0.999 0.988 1.01 PRS_PLINK_1e.05 264.9 Lack of normal physiological development, unspecified Both 1 1 3 endocrine/metabolic brown 1, 1 0.000872 20.5 1 0 1 0.987 1.01 PRS_PLINK_1e.05 269 Proteinuria Both 9 30 3 endocrine/metabolic brown 30, 9 8, 1 7, 3 7, 1 8, 3 0.312 0.546 0.568 0.246 1.37 0.547 4.35 3.66 2.63 0.165 0.784 38.8 0.52 5920000 0.296 2.98 0.921 0.036 1.34 0.000135 3870 0.77 1.88 0.682 0.166 2.16 0.00794 224 PRS_PLINK_1e.05 270 Disorders of protein plasma/amino-acid transport and metabolism Both 4 10 3 endocrine/metabolic brown 10, 4 3, 2 2, 0 2, 0 3, 2 0.59 3.53 0.867 0.062 1.8 8.44e-05 2780 -0.629 2680 1 0 0.533 0.487 7.13 -1.25 3550 1 0 0.287 0.264 3.79 -5.21 74.5 0.944 0.025 0.00545 2.58e-10 1750 PRS_PLINK_1e.05 270.1 Disturbances of amino-acid transport Both 1 1 3 endocrine/metabolic brown 1, 1 -0.00179 179 1 0 0.998 0.973 1.06 PRS_PLINK_1e.05 270.11 Disturbances of sulphur-bearing amino-acid metabolism Both 1 0 3 endocrine/metabolic brown 0, 1 PRS_PLINK_1e.05 270.2 Disorders of amino-acid metabolism Both 0 4 3 endocrine/metabolic brown 4, 0 1 1 1 1 PRS_PLINK_1e.05 270.3 Disorders of plasma protein metabolism Both 3 10 3 endocrine/metabolic brown 10, 3 3, 2 2, 0 2, 0 3, 1 -0.0707 5.29 0.989 0.005 0.932 0.000479 305 -0.00192 4220 1 0 0.998 0.253 3.93 0.148 4540 1 0 1.16 0.0887 5.53 -1.94 68.8 0.978 0.01 0.144 2.2e-07 95700 PRS_PLINK_1e.05 270.32 Paraproteinemia Both 2 6 3 endocrine/metabolic brown 6, 2 2, 2 1, 0 1, 0 2, 0 -0.0405 301 1 0 0.96 0.426 1.22 -0.014 1320 1 0 0.986 0.596 1.57 -0.0277 2520 1 0 0.973 0.925 2.43 0.0131 802 1 0 1.01 0.65 1.61 PRS_PLINK_1e.05 270.34 Alpha-1-antitrypsin deficiency Both 0 3 3 endocrine/metabolic brown 3, 0 1 1 1 1 PRS_PLINK_1e.05 270.38 Other specified disorders of plasma protein metabolism Both 1 5 3 endocrine/metabolic brown 5, 1 2, 0 1, 0 1, 0 1, 1 -2.35 112 0.983 0.007 0.0955 5e-06 2080 0.0235 196 1 0 1.02 0.893 1.22 PRS_PLINK_1e.05 271 Disorders of carbohydrate transport and metabolism Both 2 36 3 endocrine/metabolic brown 36, 2 9, 0 9, 0 9, 1 9, 0 -0.715 0.656 0.276 0.559 0.489 0.077 1.91 -0.234 1.75 0.894 0.049 0.792 0.00409 193 PRS_PLINK_1e.05 271.3 Intestinal disaccharidase deficiencies and disaccharide malabsorption Both 1 33 3 endocrine/metabolic brown 33, 1 9, 0 8, 0 8, 1 8, 0 -0.376 0.785 0.632 0.199 0.687 0.0702 9.4 0.0339 1.99 0.986 0.006 1.03 0.00849 265 PRS_PLINK_1e.05 271.9 Other disorders of carbohydrate transport and metabolism Both 1 3 3 endocrine/metabolic brown 3, 1 1, 0 1, 0 1, 0 1, 0 -1.54 13300 1 0 0.215 1.95e-07 1.54e+08 PRS_PLINK_1e.05 272 Disorders of lipoid metabolism Both 33 28 3 endocrine/metabolic brown 28, 33 6, 6 7, 11 7, 10 7, 6 -0.185 0.329 0.574 0.241 0.831 0.45 1.53 -0.304 1.17 0.795 0.1 0.738 0.073 6.49 0.168 1.06 0.875 0.058 1.18 0.158 10.3 0.967 1.25 0.44 0.356 2.63 0.338 58.4 PRS_PLINK_1e.05 272.1 Hyperlipidemia Both 33 28 3 endocrine/metabolic brown 28, 33 6, 6 7, 11 7, 10 7, 6 -0.185 0.329 0.574 0.241 0.831 0.45 1.53 -0.304 1.17 0.795 0.1 0.738 0.073 6.49 0.168 1.06 0.875 0.058 1.18 0.158 10.3 0.967 1.25 0.44 0.356 2.63 0.338 58.4 PRS_PLINK_1e.05 272.11 Hypercholesterolemia Both 16 19 3 endocrine/metabolic brown 19, 16 5, 3 5, 4 4, 3 5, 6 0.0967 0.478 0.84 0.076 1.1 0.462 2.6 -0.117 2.02 0.954 0.021 0.889 0.00467 117 -0.403 2.02 0.842 0.075 0.669 0.00285 140 0.319 1.22 0.794 0.1 1.38 0.175 9.84 PRS_PLINK_1e.05 272.12 Hyperglyceridemia Both 5 7 3 endocrine/metabolic brown 7, 5 2, 2 2, 1 1, 0 2, 2 -0.324 1.61 0.841 0.075 0.724 0.0106 19.2 0.412 1480 1 0 1.51 0.00176 3270 -0.0071 376 1 0 0.993 0.778 1.18 -0.234 1230 1 0 0.792 0.224 1.46 PRS_PLINK_1e.05 272.13 Mixed hyperlipidemia Both 14 17 3 endocrine/metabolic brown 17, 14 5, 4 4, 2 4, 4 4, 4 -0.268 0.614 0.662 0.179 0.765 0.209 2.31 -0.827 2.59 0.749 0.125 0.438 0.000647 50.5 1 1.73 0.563 0.25 2.72 0.12 996 -1.23 1.69 0.468 0.33 0.294 0.00715 4.09 PRS_PLINK_1e.05 272.9 Unspecified disorder of lipoid metabolism Both 0 3 3 endocrine/metabolic brown 3, 0 1 1 1 1 PRS_PLINK_1e.05 274 Gout and other crystal arthropathies Both 2 27 3 endocrine/metabolic brown 27, 2 7, 1 7, 1 6, 0 7, 0 -0.685 0.652 0.293 0.533 0.504 0.0457 1.8 0.946 1.96 0.629 0.202 2.58 0.000542 1030 0.21 1.88 0.911 0.04 1.23 0.0115 88.2 -0.538 1.89 0.776 0.11 0.584 0.00237 38.7 PRS_PLINK_1e.05 274.1 Gout Both 2 27 3 endocrine/metabolic brown 27, 2 7, 1 7, 1 6, 0 7, 0 -0.685 0.652 0.293 0.533 0.504 0.0457 1.8 0.946 1.96 0.629 0.202 2.58 0.000542 1030 0.21 1.88 0.911 0.04 1.23 0.0115 88.2 -0.538 1.89 0.776 0.11 0.584 0.00237 38.7 PRS_PLINK_1e.05 274.11 Gouty arthropathy Both 1 21 3 endocrine/metabolic brown 21, 1 6, 1 5, 0 5, 0 5, 0 -0.0282 1.02 0.978 0.01 0.972 0.0484 25.3 0.282 4.43 0.949 0.023 1.33 3.8e-05 8960 0.0179 90.9 1 0 1.02 0.913 1.16 1.17 2.57 0.65 0.187 3.21 0.0308 406 PRS_PLINK_1e.05 274.2 Crystal arthropathies Both 0 2 3 endocrine/metabolic brown 2, 0 1 1 1 1 PRS_PLINK_1e.05 274.21 Chondrocalcinosis Both 0 2 3 endocrine/metabolic brown 2, 0 1 1 1 1 PRS_PLINK_1e.05 275 Disorders of mineral metabolism Both 7 47 3 endocrine/metabolic brown 47, 7 12, 2 12, 1 11, 0 12, 3 0.162 0.461 0.725 0.14 1.18 0.482 3.53 1.53 2.14 0.474 0.325 4.64 0.0101 55000 0.0836 1.35 0.951 0.022 1.09 0.0202 26.8 1.01 1.45 0.487 0.312 2.74 0.157 1110 PRS_PLINK_1e.05 275.1 Disorders of iron metabolism Both 0 4 4 hematopoietic darkorange1 4, 0 1 1 1 1 PRS_PLINK_1e.05 275.11 Hereditary hemochromatosis Both 0 3 4 hematopoietic darkorange1 3, 0 1 1 1 1 PRS_PLINK_1e.05 275.2 Disorders of copper metabolism Both 0 2 3 endocrine/metabolic brown 2, 0 1 1 1 1 PRS_PLINK_1e.05 275.3 Disorders of magnesium metabolism Both 2 19 3 endocrine/metabolic brown 19, 2 5, 1 5, 0 4, 0 5, 1 -0.208 0.885 0.814 0.089 0.812 0.0609 4.81 -0.231 2.2 0.916 0.038 0.794 0.0122 24.4 -6.25 16.2 0.699 0.155 0.00194 0.00132 0.00284 1.05 2.8 0.709 0.149 2.85 0.0211 521 PRS_PLINK_1e.05 275.5 Disorders of calcium/phosphorus metabolism Both 4 40 3 endocrine/metabolic brown 40, 4 10, 1 10, 1 10, 0 10, 2 1.25 0.863 0.147 0.834 3.5 0.684 19.3 -0.688 1.98 0.729 0.138 0.502 0.00175 1030 -0.0147 1.85 0.994 0.003 0.985 0.0131 1450 1.26 1.53 0.409 0.388 3.53 0.228 212000 PRS_PLINK_1e.05 275.51 Hypocalcemia Both 0 9 3 endocrine/metabolic brown 9, 0 3 2 2 2 PRS_PLINK_1e.05 275.53 Disorders of phosphorus metabolism Both 1 14 3 endocrine/metabolic brown 14, 1 4, 0 3, 0 3, 0 4, 1 0.362 0.842 0.667 0.176 1.44 0.356 9.14 -0.758 44.2 0.986 0.006 0.469 0.299 0.313 PRS_PLINK_1e.05 275.6 Hypercalcemia Both 4 27 3 endocrine/metabolic brown 27, 4 7, 1 7, 1 6, 0 7, 1 0.372 0.724 0.607 0.217 1.45 0.302 16.2 -0.946 2.11 0.654 0.184 0.388 0.000603 137 0.447 2.21 0.84 0.076 1.56 0.000193 124 0.47 1.93 0.807 0.093 1.6 0.000429 305 PRS_PLINK_1e.05 276 Disorders of fluid, electrolyte, and acid-base balance Both 15 47 3 endocrine/metabolic brown 47, 15 11, 1 12, 3 11, 3 12, 8 0.5 0.374 0.181 0.742 1.65 0.845 3.61 1.63 1.55 0.293 0.534 5.13 0.305 8660 1.17 1.34 0.383 0.417 3.21 0.267 182 1.78 1.23 0.148 0.828 5.95 0.823 345 PRS_PLINK_1e.05 276.1 Electrolyte imbalance Both 11 40 3 endocrine/metabolic brown 40, 11 10, 1 10, 2 10, 2 10, 6 0.635 0.454 0.162 0.79 1.89 0.855 5.33 0.761 1.48 0.607 0.217 2.14 0.0503 233 0.592 1.44 0.68 0.168 1.81 0.0281 154 1.81 1.28 0.159 0.799 6.08 0.782 1270 PRS_PLINK_1e.05 276.11 Hyperosmolality and/or hypernatremia Both 0 7 3 endocrine/metabolic brown 7, 0 2 2 1 2 PRS_PLINK_1e.05 276.12 Hyposmolality and/or hyponatremia Both 4 25 3 endocrine/metabolic brown 25, 4 7, 0 6, 0 6, 0 6, 4 0.858 0.776 0.269 0.57 2.36 0.569 30.7 1.51 1.89 0.424 0.372 4.54 0.233 9800 PRS_PLINK_1e.05 276.13 Hyperpotassemia Both 3 27 3 endocrine/metabolic brown 27, 3 7, 1 7, 1 6, 0 7, 1 -0.0267 0.617 0.965 0.015 0.974 0.239 3.86 0.788 1.94 0.684 0.165 2.2 0.00746 196 0.109 2.48 0.965 0.016 1.12 0.0131 273 0.276 1.53 0.856 0.067 1.32 0.0606 53 PRS_PLINK_1e.05 276.14 Hypopotassemia Both 2 29 3 endocrine/metabolic brown 29, 2 8, 0 7, 0 7, 0 7, 2 0.485 0.718 0.499 0.301 1.62 0.361 23.3 0.767 1.6 0.632 0.199 2.15 0.153 1130 PRS_PLINK_1e.05 276.4 Acid-base balance disorder Both 2 22 3 endocrine/metabolic brown 22, 2 6, 0 5, 0 5, 0 6, 2 0.14 0.706 0.843 0.074 1.15 0.228 6.49 0.645 1.51 0.67 0.174 1.91 0.148 51 PRS_PLINK_1e.05 276.41 Acidosis Both 2 20 3 endocrine/metabolic brown 20, 2 5, 0 5, 0 5, 0 5, 2 0.43 0.782 0.582 0.235 1.54 0.353 23.3 0.612 2.31 0.791 0.102 1.84 0.0515 209 PRS_PLINK_1e.05 276.42 Alkalosis Both 0 6 3 endocrine/metabolic brown 6, 0 2 1 1 2 PRS_PLINK_1e.05 276.5 Hypovolemia Both 6 39 3 endocrine/metabolic brown 39, 6 10, 0 10, 1 9, 1 10, 4 0.237 0.501 0.636 0.196 1.27 0.42 3.79 0.718 1.44 0.619 0.208 2.05 0.131 740 0.411 1.32 0.756 0.122 1.51 0.107 55.6 1.63 1.73 0.346 0.46 5.12 0.0928 3910 PRS_PLINK_1e.05 276.6 Fluid overload Both 0 16 3 endocrine/metabolic brown 16, 0 4 4 4 4 PRS_PLINK_1e.05 276.8 Polydipsia Both 0 3 3 endocrine/metabolic brown 3, 0 1 1 1 1 PRS_PLINK_1e.05 277 Other disorders of metabolism Both 9 43 3 endocrine/metabolic brown 43, 9 11, 2 11, 3 10, 3 11, 1 -0.0267 0.427 0.95 0.022 0.974 0.417 2.25 0.745 1.29 0.564 0.248 2.11 0.209 1130 2.29 1.8 0.203 0.692 9.91 0.134 15400 0.333 1.78 0.852 0.07 1.4 0.0234 400 PRS_PLINK_1e.05 277.2 Other disorders of purine and pyrimidine metabolism Both 0 18 3 endocrine/metabolic brown 18, 0 5 4 4 5 PRS_PLINK_1e.05 277.4 Disorders of bilirubin excretion Both 1 13 3 endocrine/metabolic brown 13, 1 4, 0 3, 0 3, 1 3, 0 -0.689 1.31 0.599 0.222 0.502 0.0224 3.84 0.0193 122 1 0 1.02 0.878 1.21 PRS_PLINK_1e.05 277.5 Other disorders of lipoid metabolism Both 2 21 3 endocrine/metabolic brown 21, 2 6, 0 5, 0 5, 1 5, 1 -0.0812 0.915 0.929 0.032 0.922 0.126 32.6 0.0409 2020 1 0 1.04 0.522 1.05 -0.279 3.1 0.928 0.032 0.756 0.0105 121 PRS_PLINK_1e.05 277.51 Lipoprotein disorders Both 0 16 3 endocrine/metabolic brown 16, 0 4 4 4 4 PRS_PLINK_1e.05 277.7 Dysmetabolic syndrome X Both 4 24 3 endocrine/metabolic brown 24, 4 6, 2 6, 0 6, 2 6, 0 0.209 0.91 0.818 0.087 1.23 0.19 43.3 -0.194 1.88 0.918 0.037 0.824 0.0113 137 -0.00359 1.92 0.999 0.001 0.996 0.0155 71.5 -0.322 2.75 0.907 0.042 0.725 0.000433 260 PRS_PLINK_1e.05 278 Overweight, obesity and other hyperalimentation Both 22 42 3 endocrine/metabolic brown 42, 22 10, 7 10, 5 10, 4 11, 6 -0.459 0.326 0.16 0.796 0.632 0.332 1.14 -0.833 1.12 0.456 0.341 0.435 0.0416 3.27 -1.69 1.51 0.263 0.581 0.185 0.000215 2.7 -2 1.23 0.105 0.979 0.136 0.00798 1.08 PRS_PLINK_1e.05 278.1 Obesity Both 20 42 3 endocrine/metabolic brown 42, 20 10, 6 10, 4 10, 4 11, 6 -0.397 0.332 0.231 0.637 0.672 0.352 1.23 -0.738 1.13 0.514 0.289 0.478 0.0437 3.77 -1.46 1.4 0.296 0.529 0.231 0.000305 2.89 -1.54 1.22 0.206 0.686 0.214 0.0114 1.71 PRS_PLINK_1e.05 278.11 Morbid obesity Both 6 38 3 endocrine/metabolic brown 38, 6 9, 1 9, 1 9, 2 10, 2 0.657 0.688 0.34 0.469 1.93 0.475 14.1 -0.58 1.87 0.756 0.121 0.56 0.00364 55.6 0.493 1.75 0.778 0.109 1.64 0.00366 2560 0.129 2.19 0.953 0.021 1.14 0.0137 294000 PRS_PLINK_1e.05 278.3 Localized adiposity Both 0 8 3 endocrine/metabolic brown 8, 0 2 2 2 2 PRS_PLINK_1e.05 278.4 Abnormal weight gain Both 2 36 3 endocrine/metabolic brown 36, 2 9, 2 9, 0 9, 0 9, 0 -2.05 1.22 0.0937 1.028 0.128 8.17e-05 1.07 -2.41 2.28 0.291 0.536 0.0897 1.34e-05 3.72 -2.39 1.94 0.217 0.663 0.0918 0.000569 2.29 -2.65 2.02 0.19 0.722 0.0704 0.000274 1.83 PRS_PLINK_1e.05 279 Disorders involving the immune mechanism Both 7 37 3 endocrine/metabolic brown 37, 7 10, 1 9, 2 9, 2 9, 1 -0.122 0.463 0.792 0.101 0.885 0.358 2.22 -0.0375 1.61 0.981 0.008 0.963 9.84e-05 182000 0.251 1.31 0.848 0.072 1.29 0.117 27 0.633 1.57 0.687 0.163 1.88 0.0363 832 PRS_PLINK_1e.05 279.1 Immunity deficiency Both 3 15 3 endocrine/metabolic brown 15, 3 4, 1 4, 0 3, 1 4, 0 -0.59 0.802 0.462 0.335 0.554 0.0511 2.57 0.194 9 0.983 0.008 1.21 1.41 6.76 -0.175 695 1 0 0.839 0.482 4.53 -0.043 2.51 0.986 0.006 0.958 0.199 2.79 PRS_PLINK_1e.05 279.11 Deficiency of humoral immunity Both 2 6 3 endocrine/metabolic brown 6, 2 2, 1 1, 0 1, 0 2, 0 -1.29 332 0.997 0.001 0.276 0.18 1.03 0.262 8170 1 0 1.3 0.378 31.3 0.586 12700 1 0 1.8 0.119 6.42 0.0644 2930 1 0 1.07 0.318 3.95 PRS_PLINK_1e.05 279.2 Autoimmune disease NEC Both 3 12 3 endocrine/metabolic brown 12, 3 3, 1 3, 1 3, 1 3, 0 -0.486 1.32 0.713 0.147 0.615 0.00547 204 -0.026 135 1 0 0.974 0.787 1.08 0.398 4290000 1 0 1.49 0.286 8.59 0.117 1320 1 0 1.12 0.759 1.39 PRS_PLINK_1e.05 279.7 Other immunological findings Both 12 42 3 endocrine/metabolic brown 42, 12 11, 3 10, 1 10, 4 11, 3 0.0678 0.368 0.854 0.069 1.07 0.536 2.13 -2.04 2.26 0.368 0.434 0.131 1.16e-06 409 0.474 1.24 0.703 0.153 1.61 0.151 89.4 1.35 1.61 0.401 0.396 3.86 0.16 6250 PRS_PLINK_1e.05 279.8 Other specified disorders involving the immune mechanism Both 3 9 3 endocrine/metabolic brown 9, 3 3, 1 2, 1 2, 1 2, 0 -0.0176 1.37 0.99 0.004 0.983 0.0605 11.4 0.644 781 0.999 0 1.9 0.796 2 0.168 1750 1 0 1.18 0.643 1.48 0.021 1230 1 0 1.02 0.469 4.31 PRS_PLINK_1e.05 280 Iron deficiency anemias Both 11 40 4 hematopoietic darkorange1 40, 11 10, 3 10, 2 10, 2 10, 3 -0.258 0.369 0.484 0.315 0.772 0.372 1.5 1.22 1.44 0.397 0.401 3.38 0.296 389 -1.14 1.37 0.406 0.391 0.321 0.00136 3.59 0.814 1.34 0.544 0.265 2.26 0.211 57.8 PRS_PLINK_1e.05 280.1 Iron deficiency anemias, unspecified or not due to blood loss Both 11 39 4 hematopoietic darkorange1 39, 11 10, 3 10, 2 9, 2 10, 3 -0.257 0.369 0.485 0.314 0.773 0.373 1.5 1.22 1.44 0.397 0.401 3.38 0.296 389 -0.835 1.35 0.537 0.27 0.434 0.0255 494 0.814 1.34 0.544 0.265 2.26 0.211 57.8 PRS_PLINK_1e.05 280.2 Iron deficiency anemia secondary to blood loss (chronic) Both 3 16 4 hematopoietic darkorange1 16, 3 4, 2 4, 1 4, 0 4, 0 -1.83 1.26 0.146 0.834 0.161 0.00274 1.14 -1.5 5.42 0.782 0.107 0.223 0.00585 11.6 -0.503 21.3 0.981 0.008 0.605 1.48e-05 21900 -2.38 3.63 0.513 0.29 0.0928 0.000113 9.45 PRS_PLINK_1e.05 281 Other deficiency anemia Both 1 6 4 hematopoietic darkorange1 6, 1 2, 1 1, 0 1, 0 2, 0 -1.27 102 0.99 0.004 0.282 1.01e-08 7740000 0.0427 934 1 0 1.04 0.877 1.45 -0.414 7130 1 0 0.661 0.35 3.28 -0.169 2820 1 0 0.845 0.106 10.5 PRS_PLINK_1e.05 281.1 Megaloblastic anemia Both 0 4 4 hematopoietic darkorange1 4, 0 1 1 1 1 PRS_PLINK_1e.05 281.11 Pernicious anemia Both 0 3 4 hematopoietic darkorange1 3, 0 1 1 1 1 PRS_PLINK_1e.05 281.12 Other vitamin B12 deficiency anemia Both 0 3 4 hematopoietic darkorange1 3, 0 1 1 1 1 PRS_PLINK_1e.05 281.9 Deficiency anemias Both 1 1 4 hematopoietic darkorange1 1, 1 0.0198 107 1 0 1.02 0.153 2.24 PRS_PLINK_1e.05 282 Hereditary hemolytic anemias Both 1 5 4 hematopoietic darkorange1 5, 1 2, 0 1, 0 1, 0 1, 1 -0.683 5460 1 0 0.505 0.000455 95.1 -0.14 95500 1 0 0.869 0.0652 1.09e+14 PRS_PLINK_1e.05 282.8 Other hemoglobinopathies Both 1 3 4 hematopoietic darkorange1 3, 1 1, 0 1, 0 1, 1 1, 0 -0.493 6480 1 0 0.611 0.0348 3.44 -0.00572 21.9 1 0 0.994 0.81 1.08 PRS_PLINK_1e.05 282.9 Other hereditary hemolytic anemias Both 1 2 4 hematopoietic darkorange1 2, 1 1, 0 1, 1 1, 0 1, 1 -2.73 5370 1 0 0.0652 2.82e-22 4.75e+19 0.000289 62.5 1 0 1 0.961 1.03 PRS_PLINK_1e.05 284 Aplastic anemia Both 1 7 4 hematopoietic darkorange1 7, 1 2, 0 2, 1 1, 0 2, 0 -0.0394 44.8 0.999 0 0.961 0.706 1.38 0.0877 915 1 0 1.09 0.822 2.27 PRS_PLINK_1e.05 284.1 Pancytopenia Both 1 6 4 hematopoietic darkorange1 6, 1 2, 0 1, 0 1, 1 2, 0 0.16 187 0.999 0 1.17 0.703 1.92 0.0958 682 1 0 1.1 0.769 3.36 PRS_PLINK_1e.05 285 Other anemias Both 13 43 4 hematopoietic darkorange1 43, 13 11, 4 11, 3 10, 3 11, 3 -0.317 0.399 0.427 0.369 0.729 0.33 1.54 0.197 1.08 0.855 0.068 1.22 0.17 10.7 0.6 1.23 0.627 0.203 1.82 0.201 24.5 2.66 2.25 0.236 0.627 14.3 0.307 1.79e+08 PRS_PLINK_1e.05 285.1 Acute posthemorrhagic anemia Both 0 29 4 hematopoietic darkorange1 29, 0 8 7 7 7 PRS_PLINK_1e.05 285.2 Anemia of chronic disease Both 1 23 4 hematopoietic darkorange1 23, 1 6, 1 6, 0 5, 0 6, 0 -0.71 1.13 0.528 0.277 0.492 0.00615 5.06 1.11 3.15 0.724 0.14 3.04 0.0243 3.36 -2.1 4.16 0.613 0.213 0.122 2.47e-06 300 -0.726 3.55 0.838 0.077 0.484 7.86e-06 1820 PRS_PLINK_1e.05 285.21 Anemia in chronic kidney disease Both 0 16 4 hematopoietic darkorange1 16, 0 4 4 4 4 PRS_PLINK_1e.05 285.22 Anemia in neoplastic disease Both 0 5 4 hematopoietic darkorange1 5, 0 2 1 1 1 PRS_PLINK_1e.05 286 Coagulation defects Both 7 40 4 hematopoietic darkorange1 40, 7 9, 1 10, 0 10, 2 10, 4 0.691 0.567 0.223 0.651 2 0.681 11.4 0.0528 1.7 0.975 0.011 1.05 0.00396 220 -1.14 1.83 0.531 0.275 0.319 0.000328 8.72 6.59 4.6 0.152 0.819 728 0.166 1320 PRS_PLINK_1e.05 286.1 Congenital coagulation defects Both 0 8 4 hematopoietic darkorange1 8, 0 1 2 2 2 PRS_PLINK_1e.05 286.11 Von willebrand's disease Both 0 3 4 hematopoietic darkorange1 3, 0 1 1 1 1 PRS_PLINK_1e.05 286.12 Congenital deficiency of other clotting factors (including factor VII) Both 0 4 4 hematopoietic darkorange1 4, 0 1 1 1 1 PRS_PLINK_1e.05 286.2 Encounter for long-term (current) use of anticoagulants Both 3 32 4 hematopoietic darkorange1 32, 3 8, 2 8, 0 8, 0 8, 1 -0.55 0.664 0.408 0.39 0.577 0.0055 2.34 -1.52 1.9 0.423 0.374 0.218 1.48e-07 7.91 -1.3 1.52 0.393 0.406 0.272 0.00383 3.39 -3.04 2.5 0.223 0.651 0.0477 7.69e-06 4.5 PRS_PLINK_1e.05 286.3 Coagulation defects complicating pregnancy or postpartum Female 1 2 4 hematopoietic darkorange1 2, 1 1, 0 1, 1 1, 0 1, 1 12.5 22600 1 0 260000 8.76e-39 6.51e+53 16.1 31300 1 0 9990000 2.28e-24 2.79e+43 PRS_PLINK_1e.05 286.4 Acquired coagulation factor deficiency Both 0 3 4 hematopoietic darkorange1 3, 0 1 1 1 1 PRS_PLINK_1e.05 286.5 Hemorrhagic disorder due to intrinsic circulating anticoagulants Both 0 4 4 hematopoietic darkorange1 4, 0 1 1 1 1 PRS_PLINK_1e.05 286.6 Defibrination syndrome Both 5 37 4 hematopoietic darkorange1 37, 5 9, 0 9, 0 9, 2 9, 3 0.825 0.603 0.172 0.766 2.28 0.691 89.9 -0.119 2.12 0.955 0.02 0.888 0.000266 725 -0.45 2.14 0.834 0.079 0.638 0.00301 232 PRS_PLINK_1e.05 286.7 Other and unspecified coagulation defects Both 6 40 4 hematopoietic darkorange1 40, 6 9, 1 10, 0 10, 2 10, 3 0.662 0.545 0.225 0.648 1.94 0.692 10.1 -0.547 1.37 0.689 0.162 0.578 0.00687 7.29 -1.66 2.07 0.423 0.374 0.19 2.33e-05 6.62 3.46 3.25 0.288 0.541 31.8 0.0259 11100 PRS_PLINK_1e.05 286.8 Hypercoagulable state Both 1 13 4 hematopoietic darkorange1 13, 1 4, 0 3, 0 3, 1 3, 0 -0.171 1.79 0.924 0.034 0.843 0.0154 50.6 0.154 121 0.999 0 1.17 0.466 2.91 PRS_PLINK_1e.05 286.81 Primary hypercoagulable state Both 1 11 4 hematopoietic darkorange1 11, 1 3, 0 3, 0 2, 1 3, 0 -0.0553 2.2 0.98 0.009 0.946 0.014 112 0.0909 588 1 0 1.1 0.664 3.18 PRS_PLINK_1e.05 286.9 Abnormal coagulation profile Both 2 14 4 hematopoietic darkorange1 14, 2 4, 0 3, 0 3, 0 4, 2 0.663 1.35 0.625 0.204 1.94 0.202 2900 1.21 7.41 0.87 0.06 3.36 2.02 4.08 PRS_PLINK_1e.05 287 Purpura and other hemorrhagic conditions Both 3 36 4 hematopoietic darkorange1 36, 3 9, 0 9, 0 9, 1 9, 2 0.484 0.638 0.448 0.349 1.62 0.328 10.3 0.429 1.82 0.814 0.089 1.54 0.0395 7640 -0.303 1.77 0.864 0.063 0.739 2.33e-05 597 PRS_PLINK_1e.05 287.1 Spontaneous ecchymoses Both 0 3 4 hematopoietic darkorange1 3, 0 1 1 1 1 PRS_PLINK_1e.05 287.3 Thrombocytopenia Both 3 33 4 hematopoietic darkorange1 33, 3 9, 0 8, 0 8, 1 8, 2 0.652 0.698 0.35 0.456 1.92 0.377 36 0.248 1.75 0.887 0.052 1.28 0.0376 70.1 0.0335 1.68 0.984 0.007 1.03 0.00148 223 PRS_PLINK_1e.05 287.31 Primary thrombocytopenia Both 1 5 4 hematopoietic darkorange1 5, 1 2, 0 1, 0 1, 0 1, 1 0.000126 2810 1 0 1 0.445 1.34 0.792 22800 1 0 2.21 0.194 5.07 PRS_PLINK_1e.05 287.32 Secondary thrombocytopenia Both 1 10 4 hematopoietic darkorange1 10, 1 3, 0 2, 0 2, 0 3, 1 1.17 1.89 0.536 0.271 3.22 0.271 81.8 -1.53 1540 0.999 0 0.217 1.67e-13 9.62e+11 PRS_PLINK_1e.05 287.4 Qualitative platelet defects Both 0 2 4 hematopoietic darkorange1 2, 0 1 1 1 1 PRS_PLINK_1e.05 288 Diseases of white blood cells Both 7 51 4 hematopoietic darkorange1 51, 7 13, 1 13, 1 12, 4 13, 1 0.385 0.436 0.377 0.423 1.47 0.643 3.75 0.0432 1.5 0.977 0.01 1.04 0.00345 121 0.796 1.1 0.468 0.329 2.22 0.254 24.7 0.61 1.43 0.67 0.174 1.84 0.0696 44300 PRS_PLINK_1e.05 288.1 Decreased white blood cell count Both 2 19 4 hematopoietic darkorange1 19, 2 5, 1 5, 0 4, 1 5, 0 0.377 0.846 0.656 0.183 1.46 0.128 61.3 0.0185 1170 1 0 1.02 0.679 1.62 -0.0649 1780 1 0 0.937 0.359 1.54 -0.893 2.73 0.744 0.129 0.41 0.00174 33.2 PRS_PLINK_1e.05 288.11 Neutropenia Both 2 17 4 hematopoietic darkorange1 17, 2 5, 1 4, 0 4, 1 4, 0 0.15 0.792 0.85 0.071 1.16 0.218 10.9 -0.0635 779 1 0 0.938 0.362 1.42 -0.195 2.38 0.935 0.029 0.823 0.0189 33 -0.665 2.28 0.77 0.113 0.514 0.0141 16.8 PRS_PLINK_1e.05 288.2 Elevated white blood cell count Both 5 47 4 hematopoietic darkorange1 47, 5 12, 1 12, 1 11, 3 12, 0 0.0778 0.495 0.875 0.058 1.08 0.407 3.14 -0.228 1.29 0.86 0.066 0.796 0.00601 10.8 0.903 1.52 0.553 0.257 2.47 0.135 267 0.0659 1.52 0.966 0.015 1.07 0.0226 221 PRS_PLINK_1e.05 288.3 Eosinophilia Both 2 0 4 hematopoietic darkorange1 0, 2 PRS_PLINK_1e.05 289 Other diseases of blood and blood-forming organs Both 2 26 4 hematopoietic darkorange1 26, 2 7, 0 6, 0 6, 0 7, 2 0.477 0.665 0.474 0.325 1.61 0.419 18 0.89 1.84 0.629 0.201 2.44 0.052 204 PRS_PLINK_1e.05 289.3 Personal history of diseases of blood and blood-forming organs Both 1 15 4 hematopoietic darkorange1 15, 1 4, 0 4, 0 3, 0 4, 1 0.787 1.02 0.439 0.357 2.2 0.513 47.9 1.89 123 0.988 0.005 6.64 0.0783 812 PRS_PLINK_1e.05 289.4 Lymphadenitis Both 5 45 4 hematopoietic darkorange1 45, 5 12, 0 11, 1 11, 2 11, 1 0.166 0.407 0.684 0.165 1.18 0.548 2.72 0.308 1.32 0.815 0.089 1.36 0.0496 47 0.9 1.3 0.488 0.311 2.46 0.107 75.4 0.54 1.31 0.68 0.167 1.72 0.0787 77.4 PRS_PLINK_1e.05 289.5 Diseases of spleen Both 0 5 4 hematopoietic darkorange1 5, 0 2 1 1 1 PRS_PLINK_1e.05 289.8 Polycythemia, secondary Both 1 9 4 hematopoietic darkorange1 9, 1 3, 0 2, 0 2, 1 2, 0 0.0523 394 1 0 1.05 0.428 2.68 0.304 473 0.999 0 1.35 0.9 1.37 PRS_PLINK_1e.05 289.9 Abnormality of red blood cells Both 0 8 4 hematopoietic darkorange1 8, 0 2 2 2 2 PRS_PLINK_1e.05 290 Delirium dementia and amnestic and other cognitive disorders Both 1 9 5 mental disorders magenta 9, 1 3, 0 2, 0 2, 0 2, 1 0.551 3.33 0.869 0.061 1.74 0.0103 353 -0.136 486 1 0 0.873 0.363 1.39 PRS_PLINK_1e.05 290.1 Dementias Both 1 2 5 mental disorders magenta 2, 1 1, 0 1, 1 1, 0 1, 1 0.288 26000 1 0 1.33 0.00384 15.7 -0.272 9960 1 0 0.762 0.65 4.73 PRS_PLINK_1e.05 290.11 Alzheimer's disease Both 0 1 5 mental disorders magenta 1, 0 PRS_PLINK_1e.05 290.13 Senile dementia Both 1 3 5 mental disorders magenta 3, 1 1, 0 1, 0 1, 1 1, 0 5.47 5.89e+08 1 0 237 5.55e-09 2.08e+11 -0.00504 11.8 1 0 0.995 0.921 1.1 PRS_PLINK_1e.05 290.2 Delirium due to conditions classified elsewhere Both 0 5 5 mental disorders magenta 5, 0 2 1 1 1 PRS_PLINK_1e.05 290.3 Other persistent mental disorders due to conditions classified elsewhere Both 0 10 5 mental disorders magenta 10, 0 3 2 2 3 PRS_PLINK_1e.05 291 Other specified nonpsychotic and/or transient mental disorders Both 2 36 5 mental disorders magenta 36, 2 9, 0 9, 0 9, 1 9, 1 0.317 0.543 0.56 0.252 1.37 0.407 6.33 0.615 1.5 0.682 0.167 1.85 0.149 441 0.112 1.59 0.944 0.025 1.12 0.0169 40.2 PRS_PLINK_1e.05 291.1 Transient mental disorders due to conditions classified elsewhere Both 0 4 5 mental disorders magenta 4, 0 1 1 1 1 PRS_PLINK_1e.05 291.4 Specific nonpsychotic mental disorders due to brain damage Both 0 9 5 mental disorders magenta 9, 0 3 2 2 2 PRS_PLINK_1e.05 291.8 Alteration of consciousness Both 2 27 5 mental disorders magenta 27, 2 7, 0 7, 0 6, 2 7, 0 0.101 0.583 0.863 0.064 1.11 0.0843 4.15 -0.517 2.48 0.835 0.078 0.596 0.00563 152 PRS_PLINK_1e.05 292 Neurological disorders Both 8 51 5 mental disorders magenta 51, 8 12, 2 13, 1 12, 3 13, 2 -0.0886 0.423 0.834 0.079 0.915 0.353 2.16 -0.17 1.19 0.887 0.052 0.844 0.0792 9.66 -0.512 1.22 0.675 0.171 0.599 0.00131 6.27 -0.48 1.22 0.694 0.159 0.619 0.0463 5.86 PRS_PLINK_1e.05 292.1 Aphasia/speech disturbance Both 3 20 5 mental disorders magenta 20, 3 5, 1 5, 0 5, 1 5, 1 -0.615 1.3 0.636 0.197 0.541 0.0143 8.98 1.74 20.6 0.933 0.03 5.71 4.92 6.56 -0.237 2.66 0.929 0.032 0.789 0.713 0.853 1.32 4.1 0.747 0.126 3.75 0.00561 1940 PRS_PLINK_1e.05 292.11 Aphasia Both 2 0 5 mental disorders magenta 0, 2 PRS_PLINK_1e.05 292.12 Symbolic dysfunction Both 1 4 5 mental disorders magenta 4, 1 1, 1 1, 0 1, 0 1, 0 0.00893 11500 1 0 1.01 0.000118 464 0.00296 26.3 1 0 1 0.969 1.04 0.831 75500 1 0 2.3 0.061 36800 0.0248 50.6 1 0 1.03 0.911 1.46 PRS_PLINK_1e.05 292.2 Mild cognitive impairment Both 1 3 5 mental disorders magenta 3, 1 1, 1 1, 0 1, 0 1, 1 -0.231 6560 1 0 0.793 0.118 4.17 0.00909 50 1 0 1.01 0.924 1.12 0.00748 38.4 1 0 1.01 0.916 1.11 PRS_PLINK_1e.05 292.3 Memory loss Both 2 24 5 mental disorders magenta 24, 2 6, 1 6, 0 6, 0 6, 1 0.169 0.673 0.801 0.096 1.18 0.304 13.6 0.306 2.82 0.913 0.039 1.36 0.0125 651 -2.02 6.23 0.745 0.128 0.132 2.57e-07 1210 -0.138 1.93 0.943 0.026 0.871 0.00702 264 PRS_PLINK_1e.05 292.4 Altered mental status Both 3 28 5 mental disorders magenta 28, 3 7, 1 7, 1 7, 1 7, 0 -0.277 0.62 0.655 0.184 0.758 0.194 2.48 0.356 1.98 0.857 0.067 1.43 0.0415 961 0.0152 1.74 0.993 0.003 1.02 0.0541 46.5 0.0518 1.69 0.976 0.011 1.05 0.0444 1260 PRS_PLINK_1e.05 292.5 Transient alteration of awareness Both 0 7 5 mental disorders magenta 7, 0 2 2 1 2 PRS_PLINK_1e.05 292.6 Hallucinations Both 0 2 5 mental disorders magenta 2, 0 1 1 1 1 PRS_PLINK_1e.05 293 Symptoms involving head and neck Both 2 9 5 mental disorders magenta 9, 2 2, 0 2, 0 2, 1 2, 1 0.272 2.52 0.914 0.039 1.31 1.13 1.47 -0.0473 4930 1 0 0.954 0.0648 4.09 -0.246 8940 1 0 0.782 0.0895 4.91 PRS_PLINK_1e.05 293.1 Swelling, mass, or lump in head and neck [Space-occupying lesion, intracranial NOS] Both 4 47 5 mental disorders magenta 47, 4 12, 1 12, 1 11, 1 12, 1 0.00384 0.724 0.996 0.002 1 0.0987 94.2 0.151 1.86 0.935 0.029 1.16 0.00493 2110 0.817 1.34 0.541 0.267 2.26 0.128 66 0.121 1.45 0.934 0.03 1.13 0.0443 46.8 PRS_PLINK_1e.05 295 Schizophrenia and other psychotic disorders Both 0 7 5 mental disorders magenta 7, 0 2 2 1 2 PRS_PLINK_1e.05 295.1 Schizophrenia Both 0 1 5 mental disorders magenta 1, 0 PRS_PLINK_1e.05 295.2 Paranoid disorders Both 0 3 5 mental disorders magenta 3, 0 1 1 1 1 PRS_PLINK_1e.05 295.3 Psychosis Both 0 7 5 mental disorders magenta 7, 0 2 2 1 2 PRS_PLINK_1e.05 296 Mood disorders Both 29 19 5 mental disorders magenta 19, 29 4, 6 5, 6 4, 5 5, 12 0.000131 0.368 1 0 1 0.51 2 0.162 1.43 0.909 0.041 1.18 0.0934 13.7 -0.00512 1.65 0.998 0.001 0.995 0.0227 46.9 0.809 1.29 0.53 0.275 2.25 0.235 334 PRS_PLINK_1e.05 296.1 Bipolar Both 2 13 5 mental disorders magenta 13, 2 4, 1 3, 1 3, 0 3, 0 -0.425 1.07 0.69 0.161 0.653 0.0401 12.2 0.72 9660000 1 0 2.05 0.0082 810 0.508 3170 1 0 1.66 8.18 14.9 0.667 3510 1 0 1.95 0.179 2010 PRS_PLINK_1e.05 296.2 Depression Both 28 19 5 mental disorders magenta 19, 28 4, 6 5, 6 4, 4 5, 12 -0.0127 0.371 0.973 0.012 0.987 0.504 1.97 0.162 1.43 0.909 0.041 1.18 0.0934 13.7 -0.268 1.98 0.892 0.049 0.765 0.00108 39.1 0.809 1.29 0.53 0.275 2.25 0.235 334 PRS_PLINK_1e.05 296.22 Major depressive disorder Both 28 19 5 mental disorders magenta 19, 28 4, 6 5, 6 4, 4 5, 12 -0.0127 0.371 0.973 0.012 0.987 0.504 1.97 0.162 1.43 0.909 0.041 1.18 0.0934 13.7 -0.268 1.98 0.892 0.049 0.765 0.00108 39.1 0.809 1.29 0.53 0.275 2.25 0.235 334 PRS_PLINK_1e.05 297 Suicidal ideation or attempt Both 1 14 5 mental disorders magenta 14, 1 4, 0 3, 0 3, 0 4, 1 0.547 1.39 0.693 0.159 1.73 0.13 67.1 1.53 21.7 0.944 0.025 4.62 2.33 18 PRS_PLINK_1e.05 297.1 Suicidal ideation Both 1 10 5 mental disorders magenta 10, 1 3, 0 2, 0 2, 0 3, 1 2.07 4.78 0.664 0.178 7.94 0.00613 9.92 -0.155 17600000 1 0 0.856 0.246 2.8 PRS_PLINK_1e.05 297.2 Suicide or self-inflicted injury Both 0 7 5 mental disorders magenta 7, 0 2 2 1 2 PRS_PLINK_1e.05 300 Anxiety disorders Both 25 19 5 mental disorders magenta 19, 25 4, 4 5, 8 4, 3 5, 10 0.0263 0.41 0.949 0.023 1.03 0.477 2.26 1.45 1.33 0.276 0.559 4.27 0.444 133 -0.227 2.14 0.915 0.038 0.797 0.00202 2210 0.639 1.43 0.654 0.184 1.89 0.0965 202000 PRS_PLINK_1e.05 300.1 Anxiety disorder Both 24 19 5 mental disorders magenta 19, 24 4, 4 5, 7 4, 3 5, 10 0.0493 0.412 0.905 0.043 1.05 0.487 2.31 1.32 1.34 0.324 0.489 3.75 0.392 127 -0.227 2.14 0.915 0.038 0.797 0.00202 2210 0.639 1.43 0.654 0.184 1.89 0.0965 202000 PRS_PLINK_1e.05 300.11 Generalized anxiety disorder Both 12 18 5 mental disorders magenta 18, 12 5, 3 4, 3 4, 2 5, 4 0.0911 0.582 0.876 0.058 1.1 0.378 3.33 0.0631 3.07 0.984 0.007 1.07 4.97e-06 122 0.147 1.7 0.931 0.031 1.16 0.0835 22.7 0.761 1.83 0.678 0.169 2.14 0.0612 540 PRS_PLINK_1e.05 300.12 Agorophobia, social phobia, and panic disorder Both 2 15 5 mental disorders magenta 15, 2 4, 0 4, 0 3, 0 4, 2 1.06 1.2 0.38 0.42 2.87 0.0726 150 -7.41 39.7 0.852 0.069 0.000607 0.000372 0.00101 PRS_PLINK_1e.05 300.13 Phobia Both 3 12 5 mental disorders magenta 12, 3 2, 0 3, 1 3, 0 3, 2 0.135 0.859 0.876 0.058 1.14 0.037 7.96 0.0212 1930 1 0 1.02 0.162 1.47 0.00863 83.3 1 0 1.01 0.711 9.53 PRS_PLINK_1e.05 300.3 Obsessive-compulsive disorders Both 0 6 5 mental disorders magenta 6, 0 2 1 1 2 PRS_PLINK_1e.05 300.4 Dysthymic disorder Both 8 17 5 mental disorders magenta 17, 8 5, 2 4, 3 4, 0 4, 3 -0.227 0.845 0.788 0.103 0.797 0.0947 5.01 1.31 2.87 0.647 0.189 3.72 0.0547 761 0.771 8.36 0.927 0.033 2.16 0.0223 225 0.467 2.17 0.83 0.081 1.6 0.00225 323 PRS_PLINK_1e.05 300.8 Acute reaction to stress Both 0 2 5 mental disorders magenta 2, 0 1 1 1 1 PRS_PLINK_1e.05 300.9 Posttraumatic stress disorder Both 1 7 5 mental disorders magenta 7, 1 2, 0 2, 0 1, 1 2, 0 -0.172 7800000 1 0 0.842 0.064 31.9 -0.128 2860 1 0 0.88 0.775 2.07 PRS_PLINK_1e.05 301 Personality disorders Both 0 6 5 mental disorders magenta 6, 0 2 1 1 2 PRS_PLINK_1e.05 301.2 Antisocial/borderline personality disorder Both 0 3 5 mental disorders magenta 3, 0 1 1 1 1 PRS_PLINK_1e.05 302 Sexual and gender identity disorders Both 9 13 5 mental disorders magenta 13, 9 4, 5 3, 1 3, 0 3, 3 -0.237 1.21 0.845 0.073 0.789 0.068 14.1 -1.01 2.67 0.707 0.151 0.366 0.00128 30.3 -1.34 3.37 0.69 0.161 0.261 0.188 0.299 0.382 1.98 0.847 0.072 1.47 0.0585 1.61 PRS_PLINK_1e.05 302.1 Decreased libido Both 1 4 5 mental disorders magenta 4, 1 1, 1 1, 0 1, 0 1, 0 0.255 5450 1 0 1.29 0.112 7.85 -0.00998 147 1 0 0.99 0.853 1.17 0.00611 48.5 1 0 1.01 0.981 1.06 0.00072 4.7 1 0 1 0.984 1.02 PRS_PLINK_1e.05 303 Psychogenic and somatoform disorders Both 8 16 5 mental disorders magenta 16, 8 4, 3 4, 2 4, 1 4, 2 0.125 0.933 0.894 0.049 1.13 0.176 12.9 -0.347 6.23 0.956 0.02 0.707 2.13e-09 69000 0.647 2.63 0.806 0.094 1.91 0.00936 513 0.643 6.13 0.916 0.038 1.9 1.34e-06 3.35e+12 PRS_PLINK_1e.05 303.1 Dissociative disorder Both 0 5 5 mental disorders magenta 5, 0 2 1 1 1 PRS_PLINK_1e.05 303.3 Psychogenic disorder Both 8 16 5 mental disorders magenta 16, 8 4, 3 4, 2 4, 1 4, 2 0.125 0.933 0.894 0.049 1.13 0.176 12.9 -0.347 6.23 0.956 0.02 0.707 2.13e-09 69000 0.647 2.63 0.806 0.094 1.91 0.00936 513 0.643 6.13 0.916 0.038 1.9 1.34e-06 3.35e+12 PRS_PLINK_1e.05 303.31 Gastrointestinal malfunction arising from mental factors Both 1 5 5 mental disorders magenta 5, 1 2, 0 1, 0 1, 0 1, 1 -2.22 3.38e+08 1 0 0.109 4.87e-22 7.3e+14 -6.91 58000 1 0 0.000995 2.08e-16 3.21e+08 PRS_PLINK_1e.05 303.4 Somatoform disorder Both 0 13 5 mental disorders magenta 13, 0 4 3 3 3 PRS_PLINK_1e.05 304 Adjustment reaction Both 10 18 5 mental disorders magenta 18, 10 5, 3 4, 2 4, 1 5, 4 -0.194 0.613 0.752 0.124 0.824 0.253 2.37 -1.04 2.46 0.671 0.173 0.352 0.000923 133 0.803 2.03 0.692 0.16 2.23 0.101 173 0.285 2.08 0.891 0.05 1.33 0.0202 50.5 PRS_PLINK_1e.05 305.2 Eating disorder Both 1 10 5 mental disorders magenta 10, 1 3, 0 2, 0 2, 0 3, 1 3.27 8.7 0.707 0.15 26.3 22 31.6 -0.0237 47.5 1 0 0.977 0.75 1.23 PRS_PLINK_1e.05 306 Other mental disorder Both 6 14 5 mental disorders magenta 14, 6 4, 0 3, 1 3, 4 4, 1 -1.19 1.58 0.449 0.348 0.303 0.00659 11.1 0.393 2370 1 0 1.48 0.165 7.71 -0.177 8.56 0.983 0.007 0.837 0.821 0.854 -7.41 39.7 0.852 0.069 0.000607 0.000372 0.00101 PRS_PLINK_1e.05 306.1 Mental disorders durring/after pregnancy Female 1 6 5 mental disorders magenta 6, 1 2, 0 1, 0 1, 0 2, 1 -0.0241 805 1 0 0.976 0.648 1.39 1.19 6860000 1 0 3.3 1.19e-08 33400000 PRS_PLINK_1e.05 306.9 Tension headache Both 4 10 5 mental disorders magenta 10, 4 3, 0 2, 0 2, 2 3, 2 -0.0956 1.78 0.957 0.019 0.909 0.00322 501 -0.163 5190000 1 0 0.85 0.321 1.94 -0.862 17700000 1 0 0.422 1.81e-05 87300 PRS_PLINK_1e.05 312 Conduct disorders Both 2 1 5 mental disorders magenta 1, 2 -0.000974 499 1 0 0.999 0.992 1.01 PRS_PLINK_1e.05 312.3 Impulse control disorder Both 1 0 5 mental disorders magenta 0, 1 PRS_PLINK_1e.05 313 Pervasive developmental disorders Both 3 28 5 mental disorders magenta 28, 3 6, 0 7, 1 7, 0 7, 2 -0.0182 0.71 0.98 0.009 0.982 0.24 5.57 0.447 2.97 0.881 0.055 1.56 0.00127 2070 -0.00124 3.46 1 0 0.999 0.00022 102000 PRS_PLINK_1e.05 313.1 Attention deficit hyperactivity disorder Both 3 25 5 mental disorders magenta 25, 3 6, 0 6, 1 6, 0 6, 2 0.136 0.829 0.869 0.061 1.15 0.235 22.9 0.443 2.93 0.88 0.056 1.56 0.00239 485 -0.2 3.65 0.956 0.019 0.819 9.67e-05 252000 PRS_PLINK_1e.05 313.2 Tics and stuttering Both 0 1 5 mental disorders magenta 1, 0 PRS_PLINK_1e.05 313.3 Autism Both 0 2 5 mental disorders magenta 2, 0 1 1 1 1 PRS_PLINK_1e.05 315 Develomental delays and disorders Both 2 13 5 mental disorders magenta 13, 2 3, 0 3, 0 3, 1 3, 1 0.114 1.41 0.936 0.029 1.12 0.00847 15.4 -0.0029 28.2 1 0 0.997 0.933 2.35 -0.00106 29.6 1 0 0.999 0.93 1.11 PRS_PLINK_1e.05 315.1 Learning disorder Both 0 2 5 mental disorders magenta 2, 0 1 1 1 1 PRS_PLINK_1e.05 315.2 Speech and language disorder Both 2 5 5 mental disorders magenta 5, 2 1, 0 1, 0 1, 0 1, 2 -0.278 134 0.998 0.001 0.757 0.427 2.77 -0.0108 102 1 0 0.989 0.874 1.14 PRS_PLINK_1e.05 316 Substance addiction and disorders Both 3 49 5 mental disorders magenta 49, 3 12, 1 12, 1 12, 1 12, 0 -0.0805 0.504 0.873 0.059 0.923 0.21 3.26 -0.612 1.32 0.643 0.192 0.542 0.0116 8.89 -0.105 1.18 0.929 0.032 0.901 0.0565 11.2 -0.0814 1.4 0.954 0.021 0.922 0.0164 263 PRS_PLINK_1e.05 316.1 Polyneuropathy due to drugs Both 0 4 5 mental disorders magenta 4, 0 1 1 1 1 PRS_PLINK_1e.05 317 Alcohol-related disorders Both 0 36 5 mental disorders magenta 36, 0 8 9 9 9 PRS_PLINK_1e.05 317.1 Alcoholism Both 0 29 5 mental disorders magenta 29, 0 7 7 7 7 PRS_PLINK_1e.05 317.11 Alcoholic liver damage Both 0 7 5 mental disorders magenta 7, 0 2 2 1 2 PRS_PLINK_1e.05 318 Tobacco use disorder Both 9 51 5 mental disorders magenta 51, 9 12, 0 13, 3 12, 5 13, 1 0.415 0.435 0.34 0.469 1.51 0.67 4.04 1.07 1.41 0.448 0.349 2.92 0.16 334000 1.73 1.31 0.186 0.731 5.62 0.656 1110 -0.125 1.57 0.937 0.028 0.883 0.00076 48.6 PRS_PLINK_1e.05 320 Meningitis Both 1 3 6 neurological darkblue 3, 1 1, 1 1, 0 1, 0 1, 1 0.0129 265 1 0 1.01 0.908 5.42 0.00644 52.8 1 0 1.01 0.933 1.17 0.03 73.4 1 0 1.03 0.804 1.06 PRS_PLINK_1e.05 323 Encephalitis Both 1 1 6 neurological darkblue 1, 1 0.067 73.1 0.999 0 1.07 0.841 1.3 PRS_PLINK_1e.05 323.8 Encephalitis, non-infectious Both 1 1 6 neurological darkblue 1, 1 0.067 73.1 0.999 0 1.07 0.841 1.3 PRS_PLINK_1e.05 324 Other CNS infection and poliomyelitis Both 0 5 6 neurological darkblue 5, 0 2 1 1 1 PRS_PLINK_1e.05 327 Sleep disorders Both 24 38 6 neurological darkblue 38, 24 9, 5 9, 8 9, 8 10, 3 -0.159 0.312 0.609 0.215 0.853 0.475 1.52 0.174 0.883 0.843 0.074 1.19 0.25 5.73 0.566 0.942 0.548 0.261 1.76 0.361 11.3 -0.496 1.15 0.666 0.176 0.609 0.0618 4.57 PRS_PLINK_1e.05 327.1 Hypersomnia Both 5 21 6 neurological darkblue 21, 5 6, 1 5, 1 5, 2 5, 1 0.779 0.954 0.414 0.383 2.18 0.38 32.9 0.203 2.09 0.923 0.035 1.23 0.00318 31.8 0.816 1.72 0.635 0.198 2.26 0.156 65.2 0.16 1.64 0.922 0.035 1.17 0.0884 199 PRS_PLINK_1e.05 327.3 Sleep apnea Both 21 37 6 neurological darkblue 37, 21 9, 6 9, 7 9, 6 9, 2 -0.338 0.318 0.289 0.539 0.713 0.388 1.27 0.119 0.907 0.896 0.048 1.13 0.226 5.58 0.134 0.993 0.893 0.049 1.14 0.206 7.41 -1.3 1.4 0.355 0.45 0.274 0.00665 2.88 PRS_PLINK_1e.05 327.31 Central/nonobstroctive sleep apnea Both 2 5 6 neurological darkblue 5, 2 2, 2 1, 0 1, 0 1, 0 -0.00476 216 1 0 0.995 0.924 1.17 -0.0394 411 1 0 0.961 0.381 1.16 -0.0156 56.1 1 0 0.984 0.528 1.29 0.103 2440 1 0 1.11 0.561 1.27 PRS_PLINK_1e.05 327.32 Obstructive sleep apnea Both 18 35 6 neurological darkblue 35, 18 9, 5 9, 6 8, 5 9, 2 -0.314 0.354 0.376 0.425 0.731 0.37 1.38 0.018 0.995 0.986 0.006 1.02 0.163 5.9 0.226 0.997 0.82 0.086 1.25 0.23 7.56 -1.74 1.55 0.262 0.582 0.176 0.000148 2.55 PRS_PLINK_1e.05 327.4 Insomnia Both 10 35 6 neurological darkblue 35, 10 9, 3 9, 2 8, 4 9, 1 -0.0824 0.522 0.875 0.058 0.921 0.305 2.65 -0.0382 1.27 0.976 0.011 0.962 0.0664 16.9 1.07 1.75 0.541 0.267 2.92 0.178 580 0.654 1.72 0.704 0.153 1.92 0.0298 533 PRS_PLINK_1e.05 327.41 Organic or persistent insomnia Both 3 11 6 neurological darkblue 11, 3 3, 0 3, 1 2, 1 3, 1 0.892 2.27 0.694 0.159 2.44 0.0732 1210 -0.03 781 1 0 0.97 0.751 1.18 -0.489 5940 1 0 0.613 0.00824 44.4 1.1 3320 1 0 3.02 0.386 87.7 PRS_PLINK_1e.05 327.5 Parasomnia Both 3 9 6 neurological darkblue 9, 3 3, 0 2, 2 2, 1 2, 0 -0.429 2.34 0.854 0.068 0.651 0.00447 21.3 0.0147 148 1 0 1.01 0.782 1.7 0.046 581 1 0 1.05 0.829 1.67 PRS_PLINK_1e.05 327.6 Circadian rhythm sleep disorder Both 0 6 6 neurological darkblue 6, 0 2 1 1 2 PRS_PLINK_1e.05 327.7 Sleep related movement disorders Both 3 21 6 neurological darkblue 21, 3 6, 0 5, 2 5, 1 5, 0 0.0461 0.681 0.946 0.024 1.05 0.26 3.62 0.17 1800 1 0 1.19 0.551 1.28 0.0577 3.75 0.988 0.005 1.06 0.00316 500 PRS_PLINK_1e.05 327.71 Restless legs syndrome Both 2 17 6 neurological darkblue 17, 2 5, 0 4, 1 4, 1 4, 0 0.454 1.02 0.656 0.183 1.57 0.229 29.7 0.145 2300 1 0 1.16 0.549 3.11 0.168 4650000 1 0 1.18 0.0432 50.5 PRS_PLINK_1e.05 327.72 Sleep related leg cramps Both 0 1 6 neurological darkblue 1, 0 PRS_PLINK_1e.05 331 Other cerebral degenerations Both 2 7 6 neurological darkblue 7, 2 2, 0 2, 1 1, 0 2, 1 -1.22 56.3 0.983 0.008 0.296 0.022 1.86 0.374 1210 1 0 1.45 0.0962 25.1 -0.837 4440 1 0 0.433 0.274 5.88 PRS_PLINK_1e.05 331.1 Hydrocephalus Both 0 1 6 neurological darkblue 1, 0 PRS_PLINK_1e.05 331.9 Cerebral degeneration, unspecified Both 2 3 6 neurological darkblue 3, 2 1, 0 1, 0 1, 2 1, 0 -0.038 3280 1 0 0.963 0.247 1.92 -4.9e-05 4080 1 0 1 0.106 8.9 PRS_PLINK_1e.05 332 Parkinson's disease Both 0 1 6 neurological darkblue 1, 0 PRS_PLINK_1e.05 333 Extrapyramidal disease and abnormal movement disorders Both 6 27 6 neurological darkblue 27, 6 6, 0 7, 1 6, 1 7, 4 0.542 0.507 0.285 0.545 1.72 0.688 5.43 0.893 1.81 0.621 0.207 2.44 0.0799 6720 0.35 2.39 0.884 0.054 1.42 0.0166 109 0.499 1.75 0.776 0.11 1.65 0.0474 8910 PRS_PLINK_1e.05 333.1 Essential tremor Both 1 6 6 neurological darkblue 6, 1 2, 0 1, 0 1, 0 2, 1 0.0155 335 1 0 1.02 0.94 1.34 -0.202 2980 1 0 0.817 0.0476 16.6 PRS_PLINK_1e.05 333.2 Myoclonus Both 0 2 6 neurological darkblue 2, 0 1 1 1 1 PRS_PLINK_1e.05 333.4 Torsion dystonia Both 0 4 6 neurological darkblue 4, 0 1 1 1 1 PRS_PLINK_1e.05 333.8 Other degenerative diseases of the basal ganglia Both 1 1 6 neurological darkblue 1, 1 -0.0132 57.7 1 0 0.987 0.891 1.05 PRS_PLINK_1e.05 334 Degenerative disease of the spinal cord Both 0 11 6 neurological darkblue 11, 0 3 3 2 3 PRS_PLINK_1e.05 335 Multiple sclerosis Both 1 3 6 neurological darkblue 3, 1 1, 0 1, 1 1, 0 1, 0 -0.000566 48 1 0 0.999 0.288 5.43 -0.00305 18.6 1 0 0.997 0.979 1.05 PRS_PLINK_1e.05 337 Disorders of the autonomic nervous system Both 8 14 6 neurological darkblue 14, 8 4, 0 3, 4 3, 4 4, 0 0.142 0.732 0.846 0.073 1.15 0.292 4.37 -0.0769 3.8 0.984 0.007 0.926 3.38e-05 7710 0.458 3.06 0.881 0.055 1.58 1.42 2.14 PRS_PLINK_1e.05 337.1 Peripheral autonomic neuropathy Both 6 11 6 neurological darkblue 11, 6 3, 1 3, 3 2, 1 3, 1 -0.297 1.14 0.794 0.1 0.743 0.015 41.3 -0.509 5.39 0.925 0.034 0.601 0.55 0.678 0.00865 33.4 1 0 1.01 0.465 1.93 -2.11 8.17 0.797 0.099 0.122 0.00718 0.127 PRS_PLINK_1e.05 338 Pain Both 36 27 6 neurological darkblue 27, 36 7, 11 7, 7 6, 8 7, 9 -0.195 0.299 0.516 0.288 0.823 0.465 1.41 -0.0507 0.934 0.957 0.019 0.951 0.185 5.09 0.358 0.928 0.7 0.155 1.43 0.284 9.02 0.167 1.01 0.869 0.061 1.18 0.19 8.25 PRS_PLINK_1e.05 338.1 Acute pain Both 23 27 6 neurological darkblue 27, 23 7, 7 7, 3 6, 5 7, 7 -0.112 0.324 0.73 0.136 0.894 0.488 1.59 -0.103 1.41 0.942 0.026 0.902 0.0585 9.47 0.257 1.03 0.803 0.095 1.29 0.218 8 0.0717 1.16 0.951 0.022 1.07 0.126 9.29 PRS_PLINK_1e.05 338.2 Chronic pain Both 21 27 6 neurological darkblue 27, 21 7, 5 7, 5 6, 5 7, 6 -0.0164 0.411 0.968 0.014 0.984 0.467 2.07 0.353 1.09 0.747 0.127 1.42 0.233 9.16 0.595 1.05 0.57 0.244 1.81 0.319 12.3 0.317 1.3 0.807 0.093 1.37 0.141 19.6 PRS_PLINK_1e.05 339 Other headache syndromes Both 23 36 6 neurological darkblue 36, 23 8, 7 9, 2 9, 7 9, 7 0.0296 0.315 0.925 0.034 1.03 0.575 1.86 0.0325 1.35 0.981 0.008 1.03 0.0874 17.8 0.422 0.943 0.654 0.184 1.53 0.284 13.9 0.156 1.05 0.882 0.055 1.17 0.175 8.21 PRS_PLINK_1e.05 340 Migraine Both 19 35 6 neurological darkblue 35, 19 8, 5 9, 3 8, 6 9, 5 -0.0529 0.338 0.876 0.058 0.948 0.503 1.79 1.31 1.43 0.361 0.443 3.69 0.358 156 0.114 1.02 0.91 0.041 1.12 0.174 7.33 0.399 1.24 0.747 0.127 1.49 0.162 23.4 PRS_PLINK_1e.05 340.1 Migrain with aura Both 8 25 6 neurological darkblue 25, 8 7, 5 6, 1 6, 0 6, 2 -0.573 0.579 0.322 0.492 0.564 0.17 1.58 -1.6 2.04 0.434 0.362 0.202 0.000336 3.86 -2.33 1.91 0.223 0.652 0.0977 1.5e-08 1.43 -0.907 1.45 0.531 0.275 0.404 0.026 4.39 PRS_PLINK_1e.05 342 Hemiplegia Both 0 5 6 neurological darkblue 5, 0 2 1 1 1 PRS_PLINK_1e.05 343 Infantile cerebral palsy Both 0 1 6 neurological darkblue 1, 0 PRS_PLINK_1e.05 344 Other paralytic syndromes Both 1 6 6 neurological darkblue 6, 1 2, 1 1, 0 1, 0 2, 0 0.0623 12200000 1 0 1.06 0.0804 20.1 0.461 1.66e+08 1 0 1.59 0.00176 3010 1.06e-05 31000 1 0 1 7e-08 1.22e+12 -2.33 8120 1 0 0.0977 2.97e-06 15.9 PRS_PLINK_1e.05 345 Epilepsy, recurrent seizures, convulsions Both 5 34 6 neurological darkblue 34, 5 9, 0 8, 1 8, 1 9, 3 0.509 0.519 0.327 0.485 1.66 0.626 8.49 0.348 1.45 0.811 0.091 1.42 0.0428 121 0.715 1.79 0.689 0.162 2.04 0.0255 758 0.587 1.44 0.684 0.165 1.8 0.0623 46.7 PRS_PLINK_1e.05 345.1 Epilepsy Both 1 13 6 neurological darkblue 13, 1 4, 0 3, 0 3, 1 3, 0 -0.142 1.48 0.924 0.034 0.868 0.0487 19.9 0.326 409 0.999 0 1.39 1.99 7.22 PRS_PLINK_1e.05 345.11 Generalized convulsive epilepsy Both 1 3 6 neurological darkblue 3, 1 1, 0 1, 0 0, 1 1, 0 -0.221 1550 1 0 0.802 0.165 1.55 -0.00546 186 1 0 0.995 0.849 1.18 PRS_PLINK_1e.05 345.12 Partial epilepsy Both 1 6 6 neurological darkblue 6, 1 2, 0 1, 0 1, 0 2, 1 -0.0358 1070 1 0 0.965 0.461 1.79 13.3 43200000 1 0 568000 2.17e-10 3.57e+24 PRS_PLINK_1e.05 345.3 Convulsions Both 5 32 6 neurological darkblue 32, 5 8, 0 8, 1 8, 1 8, 3 0.446 0.502 0.374 0.427 1.56 0.608 7.78 0.357 1.51 0.813 0.09 1.43 0.0771 45.6 0.0415 1.52 0.978 0.01 1.04 0.0456 20.3 0.399 1.54 0.795 0.1 1.49 0.0848 41.6 PRS_PLINK_1e.05 346 Abnormal findings on study of brain and/or nervous system Both 0 5 6 neurological darkblue 5, 0 2 1 1 1 PRS_PLINK_1e.05 346.1 Nonspecific abnormal findings on radiological and other examination of skull and head Both 3 12 6 neurological darkblue 12, 3 3, 0 3, 0 3, 2 3, 1 0.375 1.05 0.721 0.142 1.46 0.289 12.7 0.0162 832 1 0 1.02 0.575 1.86 -0.235 1370 1 0 0.79 0.112 7.22 PRS_PLINK_1e.05 346.2 Nonspecific abnormal results of function study of brain and central nervous system Both 0 2 6 neurological darkblue 2, 0 1 1 1 1 PRS_PLINK_1e.05 347 Cataplexy and narcolepsy Both 0 1 6 neurological darkblue 1, 0 PRS_PLINK_1e.05 348 Other conditions of brain Both 2 17 6 neurological darkblue 17, 2 5, 0 4, 1 4, 1 4, 0 -0.19 0.645 0.768 0.115 0.827 0.0975 7.92 -0.996 287 0.997 0.001 0.369 0.125 1.3 2.24e-14 5.51 1 0 1 0.00033 7770 PRS_PLINK_1e.05 348.2 Cerebral edema and compression of brain Both 1 10 6 neurological darkblue 10, 1 3, 1 2, 0 2, 0 3, 0 -0.318 2.27 0.889 0.051 0.727 0.012 128 -0.375 606 1 0 0.687 0.15 6.03 -0.0837 674 1 0 0.92 0.812 1.32 -0.503 816 1 0 0.604 0.0123 13 PRS_PLINK_1e.05 348.4 Cerebral cysts Both 0 4 6 neurological darkblue 4, 0 1 1 1 1 PRS_PLINK_1e.05 348.7 Coma Both 0 2 6 neurological darkblue 2, 0 1 1 1 1 PRS_PLINK_1e.05 348.8 Encephalopathy, not elsewhere classified Both 0 6 6 neurological darkblue 6, 0 2 1 1 2 PRS_PLINK_1e.05 348.9 Other conditions of brain, NOS Both 3 20 6 neurological darkblue 20, 3 5, 2 5, 0 5, 1 5, 0 -0.889 0.699 0.204 0.691 0.411 0.0161 1.27 0.915 6.46 0.887 0.052 2.5 0.00111 3580 -1.6 2.3 0.486 0.314 0.202 0.00399 4.56 0.983 4.01 0.806 0.094 2.67 0.00619 2050 PRS_PLINK_1e.05 349 Other and unspecified disorders of the nervous system Both 1 10 6 neurological darkblue 10, 1 3, 0 2, 1 2, 0 3, 0 -0.262 0.954 0.784 0.106 0.77 0.0615 3.22 0.577 73.6 0.994 0.003 1.78 1e-05 26400 PRS_PLINK_1e.05 350 Abnormal movement Both 12 46 6 neurological darkblue 46, 12 11, 5 11, 2 11, 3 12, 2 -0.469 0.435 0.281 0.552 0.626 0.247 1.43 -1.4 1.18 0.234 0.631 0.246 0.0196 1.76 -2.01 1.29 0.119 0.924 0.135 0.00264 1.21 -1.16 1.25 0.352 0.454 0.313 0.0247 2.64 PRS_PLINK_1e.05 350.1 Abnormal involuntary movements Both 5 33 6 neurological darkblue 33, 5 9, 3 8, 0 8, 2 8, 0 -0.586 0.558 0.294 0.532 0.556 0.113 1.55 -1.41 1.52 0.355 0.45 0.245 6.94e-06 2.64 -1.48 1.56 0.343 0.465 0.227 0.00166 3.05 -1.72 1.89 0.363 0.44 0.18 8.75e-05 6.88 PRS_PLINK_1e.05 350.2 Abnormality of gait Both 8 28 6 neurological darkblue 28, 8 7, 2 7, 1 7, 3 7, 2 0.236 0.63 0.707 0.15 1.27 0.328 4.72 -1.12 1.96 0.567 0.247 0.326 0.00582 110 -0.848 1.73 0.624 0.205 0.428 0.0067 9.05 -0.253 2.18 0.908 0.042 0.777 0.00647 483 PRS_PLINK_1e.05 350.3 Lack of coordination Both 3 12 6 neurological darkblue 12, 3 2, 2 3, 0 3, 0 3, 1 -1.34 1.21 0.272 0.566 0.263 0.00219 1.57 -0.0891 95.7 0.999 0 0.915 0.577 1.66 -0.168 1120 1 0 0.845 0.293 3.26 -0.749 982 0.999 0 0.473 0.274 0.178 PRS_PLINK_1e.05 350.5 Abnormal reflex Both 0 3 6 neurological darkblue 3, 0 1 1 1 1 PRS_PLINK_1e.05 350.6 Disturbances of sensation of smell and taste Both 0 9 6 neurological darkblue 9, 0 3 2 2 2 PRS_PLINK_1e.05 351 Other peripheral nerve disorders Both 18 39 6 neurological darkblue 39, 18 10, 9 10, 4 9, 5 10, 0 -1.07 0.455 0.0189 1.724 0.344 0.12 0.765 -0.596 0.904 0.51 0.293 0.551 0.0958 2.65 -0.943 1.05 0.37 0.432 0.39 0.0216 2.24 -2.12 1.38 0.123 0.909 0.12 0.00113 1.07 PRS_PLINK_1e.05 352 Disorders of other cranial nerves Both 2 13 6 neurological darkblue 13, 2 4, 1 3, 0 3, 1 3, 0 -0.107 2.04 0.958 0.019 0.898 0.000147 157 -0.0715 276 1 0 0.931 0.824 1.34 -0.0413 1600 1 0 0.96 0.245 1.65 -0.328 1550 1 0 0.72 1.86e-10 6.26e+11 PRS_PLINK_1e.05 352.1 Trigeminal nerve disorders [CN5] Both 1 7 6 neurological darkblue 7, 1 2, 0 2, 0 1, 1 2, 0 -0.017 796 1 0 0.983 1.39 3.69 -0.104 6600 1 0 0.901 0.344 3.42 PRS_PLINK_1e.05 352.2 Facial nerve disorders [CN7] Both 1 5 6 neurological darkblue 5, 1 2, 1 1, 0 1, 0 1, 0 0.00916 300 1 0 1.01 0.908 1.24 10.8 20400 1 0 48900 0.000634 1.98e+12 0.0546 550 1 0 1.06 0.589 1.64 -1.59 3180 1 0 0.204 0.000236 106 PRS_PLINK_1e.05 353 Nerve root and plexus disorders Both 3 33 6 neurological darkblue 33, 3 9, 1 8, 1 8, 0 8, 1 -0.377 0.542 0.486 0.313 0.686 0.169 2.08 0.613 1.45 0.673 0.172 1.85 0.135 35.7 -0.259 1.48 0.86 0.065 0.772 0.0228 41.2 0.43 1.66 0.795 0.1 1.54 0.0788 58.3 PRS_PLINK_1e.05 353.1 Nerve plexus lesions Both 0 2 6 neurological darkblue 2, 0 1 1 1 1 PRS_PLINK_1e.05 355 Complex regional/central pain syndrome Both 0 6 6 neurological darkblue 6, 0 2 1 1 2 PRS_PLINK_1e.05 355.1 Chronic pain syndrome Both 0 11 6 neurological darkblue 11, 0 3 3 2 3 PRS_PLINK_1e.05 356 Hereditary and idiopathic peripheral neuropathy Both 13 19 6 neurological darkblue 19, 13 5, 2 5, 2 4, 3 5, 6 -0.597 0.661 0.366 0.436 0.55 0.127 1.71 1.46 2.01 0.467 0.331 4.32 0.212 1040 0.886 1.63 0.587 0.232 2.42 0.183 77.2 0.154 1.86 0.934 0.03 1.17 0.0475 25.5 PRS_PLINK_1e.05 357 Inflammatory and toxic neuropathy Both 14 23 6 neurological darkblue 23, 14 6, 4 6, 3 5, 7 6, 0 -1.18 0.763 0.122 0.914 0.307 0.0392 1.19 3.03 2.59 0.242 0.616 20.7 0.0719 294000 -0.923 1.67 0.581 0.236 0.397 0.00413 7.43 -2.68 2.69 0.318 0.497 0.0684 2.2e-05 3.74 PRS_PLINK_1e.05 358 Myoneural disorders Both 3 5 6 neurological darkblue 5, 3 2, 1 1, 0 1, 1 1, 1 -0.388 228 0.999 0.001 0.679 0.307 1.97 0.515 6940 1 0 1.67 0.24 102 0.268 996 1 0 1.31 0.763 4.5 0.0796 717 1 0 1.08 0.915 2.09 PRS_PLINK_1e.05 359 Muscular dystrophies and other myopathies Both 5 12 6 neurological darkblue 12, 5 3, 0 3, 3 3, 1 3, 1 0.506 1.58 0.748 0.126 1.66 0.132 26.8 -0.513 252 0.998 0.001 0.598 0.149 0.671 2.86 12800 1 0 17.5 2.01e-10 5.48e+13 1.81 643 0.998 0.001 6.13 0.000538 71500 PRS_PLINK_1e.05 359.2 Myopathy Both 5 10 6 neurological darkblue 10, 5 3, 0 2, 3 2, 1 3, 1 0.74 1.65 0.653 0.185 2.1 0.169 47.9 -0.0629 138 1 0 0.939 0.298 3.6 1.66 7090 1 0 5.27 9.05e-05 5910000 0.192 629 1 0 1.21 0.537 9.48 PRS_PLINK_1e.05 360.2 Progressive myopia Both 0 1 7 sense organs darkseagreen4 1, 0 PRS_PLINK_1e.05 361 Retinal detachments and defects Both 0 10 7 sense organs darkseagreen4 10, 0 3 2 2 3 PRS_PLINK_1e.05 361.1 Retinal detachment with retinal defect Both 0 6 7 sense organs darkseagreen4 6, 0 2 1 1 2 PRS_PLINK_1e.05 362 Other retinal disorders Both 11 16 7 sense organs darkseagreen4 16, 11 4, 2 4, 4 4, 0 4, 5 -0.218 0.628 0.729 0.137 0.804 0.251 2.45 0.507 1.92 0.791 0.102 1.66 0.0145 58.4 2.41 124 0.985 0.007 11.1 11.1 380000 1.33 1.74 0.446 0.351 3.77 0.272 75.7 PRS_PLINK_1e.05 362.2 Degeneration of macula and posterior pole of retina Both 3 10 7 sense organs darkseagreen4 10, 3 3, 0 2, 1 2, 1 3, 1 0.388 1.57 0.804 0.095 1.47 0.105 1210 0.254 1840 1 0 1.29 0.0674 3.46 -1.46 48700000 1 0 0.232 5.43e-05 605 -0.0379 568 1 0 0.963 0.41 2.65 PRS_PLINK_1e.05 362.21 Macular degeneration, dry Both 0 2 7 sense organs darkseagreen4 2, 0 1 1 1 1 PRS_PLINK_1e.05 362.22 Macular degeneration, wet Both 0 1 7 sense organs darkseagreen4 1, 0 PRS_PLINK_1e.05 362.23 Cystoid macular degeneration of retina Both 0 4 7 sense organs darkseagreen4 4, 0 1 1 1 1 PRS_PLINK_1e.05 362.26 Macular puckering of retina Both 2 7 7 sense organs darkseagreen4 7, 2 2, 1 2, 1 1, 0 2, 0 -0.0762 248 1 0 0.927 0.452 1.25 -2.82 95600000 1 0 0.0597 1.53e-06 23.7 0.0702 8570 1 0 1.07 0.0198 89.1 4.97 14900 1 0 144 1.3e-06 1.66e+13 PRS_PLINK_1e.05 362.27 Drusen (degenerative) of retina Both 1 3 7 sense organs darkseagreen4 3, 1 1, 0 1, 0 1, 1 1, 0 -0.147 2340 1 0 0.864 0.234 1.45 -0.536 15500 1 0 0.585 0.136 3.1 PRS_PLINK_1e.05 362.29 Macular degeneration (senile) of retina NOS Both 3 10 7 sense organs darkseagreen4 10, 3 3, 0 2, 1 2, 1 3, 1 0.388 1.57 0.804 0.095 1.47 0.105 1210 0.254 1840 1 0 1.29 0.0674 3.46 -1.46 48700000 1 0 0.232 5.43e-05 605 -0.0379 568 1 0 0.963 0.41 2.65 PRS_PLINK_1e.05 362.3 Other nondiabetic retinopathy Both 3 9 7 sense organs darkseagreen4 9, 3 3, 0 2, 1 2, 0 2, 2 -4.11 7.87 0.601 0.221 0.0163 0.0125 75 0.248 2080 1 0 1.28 0.443 8.96 -1.32 702 0.999 0.001 0.268 0.00114 67.8 PRS_PLINK_1e.05 362.31 Separation of retinal layers Both 0 4 7 sense organs darkseagreen4 4, 0 1 1 1 1 PRS_PLINK_1e.05 362.4 Retinal vascular changes and abnomalities Both 4 3 7 sense organs darkseagreen4 3, 4 1, 2 1, 0 1, 2 1, 2 -0.00659 119 1 0 0.993 0.521 1.17 -0.00181 42.4 1 0 0.998 0.673 1.31 -0.00676 366 1 0 0.993 0.702 1.15 PRS_PLINK_1e.05 362.6 Peripheral retinal degenerations Both 2 4 7 sense organs darkseagreen4 4, 2 1, 0 1, 0 1, 0 1, 2 0.0136 122 1 0 1.01 0.63 7.61 0.0101 310 1 0 1.01 0.904 1.31 PRS_PLINK_1e.05 362.7 Hereditary retinal dystrophies Both 1 0 7 sense organs darkseagreen4 0, 1 PRS_PLINK_1e.05 362.8 Retinal hemorrhage/ischemia Both 0 2 7 sense organs darkseagreen4 2, 0 1 1 1 1 PRS_PLINK_1e.05 362.9 Retinal edema Both 1 4 7 sense organs darkseagreen4 4, 1 1, 0 1, 0 1, 0 1, 1 0.0649 2680 1 0 1.07 0.667 1.83 0.0561 4900000 1 0 1.06 0.6 1.58 PRS_PLINK_1e.05 363 Chorioretinal inflammations, scars, and other disorders of choroid Both 0 7 7 sense organs darkseagreen4 7, 0 2 2 1 2 PRS_PLINK_1e.05 363.3 Chorioretinal scars Both 0 5 7 sense organs darkseagreen4 5, 0 2 1 1 1 PRS_PLINK_1e.05 364 Corneal opacity and other disorders of cornea Both 4 15 7 sense organs darkseagreen4 15, 4 4, 2 4, 0 3, 1 4, 1 -0.0994 1.22 0.935 0.029 0.905 0.0868 17.8 0.331 4.13 0.936 0.029 1.39 0.00444 1510 0.0244 408 1 0 1.02 0.641 1.62 0.0233 85.1 1 0 1.02 0.767 2.48 PRS_PLINK_1e.05 364.1 Corneal opacity Both 2 8 7 sense organs darkseagreen4 8, 2 2, 0 2, 0 2, 1 2, 1 1.41 6.71 0.834 0.079 4.09 0.002 13800 0.289 6620 1 0 1.34 0.528 2.8 0.127 1130 1 0 1.13 0.7 2.68 PRS_PLINK_1e.05 364.2 Corneal edema Both 1 2 7 sense organs darkseagreen4 2, 1 1, 0 1, 1 1, 0 1, 1 -0.0404 1220 1 0 0.96 0.683 1.29 0.108 1830 1 0 1.11 0.0138 32.6 PRS_PLINK_1e.05 364.4 Corneal degenerations Both 3 5 7 sense organs darkseagreen4 5, 3 2, 2 1, 0 1, 0 1, 1 0.207 120 0.999 0.001 1.23 0.000144 1.28 0.595 11300 1 0 1.81 0.227 506 -0.55 1300 1 0 0.577 0.0497 4.28 0.46 1570 1 0 1.58 0.505 26.9 PRS_PLINK_1e.05 364.5 Corneal dystrophy Both 1 4 7 sense organs darkseagreen4 4, 1 1, 1 1, 0 1, 0 1, 0 0.055 3440 1 0 1.06 0.362 2.42 0.0406 53.5 0.999 0 1.04 0.839 1.22 0.0249 56.2 1 0 1.03 0.85 1.54 0.103 57.2 0.999 0.001 1.11 0.517 1.26 PRS_PLINK_1e.05 365 Glaucoma Both 10 23 7 sense organs darkseagreen4 23, 10 6, 1 6, 2 5, 2 6, 5 0.585 0.622 0.347 0.459 1.79 0.621 8.18 -1.1 1.89 0.562 0.25 0.334 0.00391 5.99 0.382 1.61 0.812 0.091 1.47 0.011 31.1 3.85 2.76 0.164 0.786 46.9 0.654 157000 PRS_PLINK_1e.05 365.1 Open-angle glaucoma Both 3 6 7 sense organs darkseagreen4 6, 3 2, 1 1, 0 1, 0 2, 2 3.67 30.5 0.904 0.044 39.1 140 760 -0.0324 1550 1 0 0.968 0.675 1.19 0.155 16200 1 0 1.17 0.543 2.18 0.102 3370 1 0 1.11 0.583 2.05 PRS_PLINK_1e.05 365.11 Primary open angle glaucoma Both 1 3 7 sense organs darkseagreen4 3, 1 1, 0 1, 0 1, 1 1, 0 0.0286 146 1 0 1.03 0.957 1.05 0.018 2670 1 0 1.02 0.94 1.04 PRS_PLINK_1e.05 365.2 Primary angle-closure glaucoma Both 0 2 7 sense organs darkseagreen4 2, 0 1 1 1 1 PRS_PLINK_1e.05 366 Cataract Both 22 22 7 sense organs darkseagreen4 22, 22 6, 12 5, 2 5, 6 6, 2 -0.945 0.592 0.111 0.956 0.389 0.0879 1.17 -2.79 1.75 0.11 0.957 0.0612 1.25e-06 0.907 -1.08 1.34 0.421 0.376 0.34 0.0055 3.5 -0.897 1.32 0.497 0.304 0.408 0.0183 5.87 PRS_PLINK_1e.05 366.1 Nonsenile Cataract Both 2 0 7 sense organs darkseagreen4 0, 2 PRS_PLINK_1e.05 366.2 Senile cataract Both 19 18 7 sense organs darkseagreen4 18, 19 5, 9 4, 2 4, 6 5, 2 -1.73 0.944 0.0665 1.177 0.177 0.0096 0.965 -3.18 2.17 0.144 0.842 0.0417 6.99e-07 0.939 -2.15 1.97 0.276 0.559 0.117 3.08e-08 5.39 -0.603 1.43 0.674 0.171 0.547 0.00467 591 PRS_PLINK_1e.05 367 Disorders of refraction and accommodation; blindness and low vision Both 25 39 7 sense organs darkseagreen4 39, 25 9, 7 10, 6 9, 9 10, 3 -0.0867 0.327 0.791 0.102 0.917 0.489 1.7 -0.272 0.876 0.756 0.121 0.762 0.158 3.5 0.316 0.869 0.716 0.145 1.37 0.304 6.32 0.0187 1.12 0.987 0.006 1.02 0.135 8.84 PRS_PLINK_1e.05 367.1 Myopia Both 22 36 7 sense organs darkseagreen4 36, 22 8, 5 9, 5 9, 9 9, 3 -0.0103 0.349 0.977 0.01 0.99 0.51 1.92 -0.107 1.07 0.921 0.036 0.899 0.138 6.07 0.554 0.929 0.551 0.259 1.74 0.364 9 0.157 1.18 0.895 0.048 1.17 0.155 9.91 PRS_PLINK_1e.05 367.2 Astigmatism Both 12 32 7 sense organs darkseagreen4 32, 12 7, 4 8, 3 8, 5 8, 0 -0.331 0.431 0.442 0.355 0.718 0.283 1.62 -0.521 1.23 0.671 0.173 0.594 0.0598 4.82 -0.123 1.09 0.91 0.041 0.884 0.108 5.49 -2.12 2.55 0.405 0.392 0.12 0.000184 6.75 PRS_PLINK_1e.05 367.8 Hypermetropia Both 0 17 7 sense organs darkseagreen4 17, 0 5 4 4 4 PRS_PLINK_1e.05 367.9 Blindness and low vision Both 3 14 7 sense organs darkseagreen4 14, 3 4, 1 3, 0 3, 0 4, 2 -0.0903 0.97 0.926 0.033 0.914 0.00286 28 -0.207 549 1 0 0.813 0.127 1.06 -0.322 402 0.999 0 0.724 0.124 1.59 -0.719 3.14 0.819 0.087 0.487 0.000578 123000 PRS_PLINK_1e.05 368 Visual disturbances Both 15 46 7 sense organs darkseagreen4 46, 15 12, 3 11, 3 11, 4 12, 5 -0.0861 0.366 0.814 0.089 0.917 0.448 1.85 0.338 1.15 0.769 0.114 1.4 0.147 15.1 -0.986 1.18 0.404 0.393 0.373 0.00179 3.35 0.225 1.06 0.831 0.08 1.25 0.184 9.64 PRS_PLINK_1e.05 368.1 Amblyopia Both 2 11 7 sense organs darkseagreen4 11, 2 3, 2 3, 0 2, 0 3, 0 -1.1 1.86 0.552 0.258 0.332 0.00408 5.23 -1.01 6620000 1 0 0.364 0.049 1.97 -0.166 2350 1 0 0.847 0.186 1.81 0.0369 921 1 0 1.04 0.788 1.74 PRS_PLINK_1e.05 368.2 Diplopia and disorders of binocular vision Both 7 13 7 sense organs darkseagreen4 13, 7 4, 4 3, 1 3, 0 3, 2 -1.83 1.18 0.122 0.913 0.161 0.00674 0.95 -0.506 2.24 0.821 0.086 0.603 0.00883 20.5 -3.03 6.2 0.625 0.204 0.0481 0.0397 38.2 -1.84 2.74 0.501 0.3 0.158 0.000639 8.19 PRS_PLINK_1e.05 368.3 Anisometropia Both 0 3 7 sense organs darkseagreen4 3, 0 1 1 1 1 PRS_PLINK_1e.05 368.4 Visual field defects Both 3 12 7 sense organs darkseagreen4 12, 3 3, 2 3, 0 3, 0 3, 1 -2.36 2.09 0.259 0.587 0.0941 0.000419 2.58 -0.114 39.6 0.998 0.001 0.893 0.645 0.782 -0.477 6750 1 0 0.62 0.589 4.64 -0.957 28.3 0.973 0.012 0.384 0.0927 2.24 PRS_PLINK_1e.05 368.9 Subjective visual disturbances Both 3 11 7 sense organs darkseagreen4 11, 3 3, 1 3, 1 2, 0 3, 1 0.359 1.66 0.829 0.082 1.43 0.0283 46.9 -0.04 257 1 0 0.961 0.63 1.18 -0.258 1840 1 0 0.772 0.202 1.41 0.0557 93.5 1 0 1.06 0.541 1.59 PRS_PLINK_1e.05 368.91 Psychophysical visual disturbances Both 0 1 7 sense organs darkseagreen4 1, 0 PRS_PLINK_1e.05 369 Infection of the eye Both 8 38 7 sense organs darkseagreen4 38, 8 9, 3 9, 2 9, 2 10, 1 0.11 0.509 0.828 0.082 1.12 0.351 3.17 -0.978 1.35 0.47 0.328 0.376 0.0235 3.28 0.339 1.4 0.809 0.092 1.4 0.0485 20.5 -0.562 1.59 0.723 0.141 0.57 0.000817 12.5 PRS_PLINK_1e.05 369.2 Eye infection, viral Both 1 11 7 sense organs darkseagreen4 11, 1 3, 1 3, 0 2, 0 3, 0 0.25 1.68 0.882 0.055 1.28 0.0371 46.9 -2.2 19400000 1 0 0.111 5.71e-10 37900000 0.0271 7930 1 0 1.03 0.0537 5.51 -1.17 2300000 1 0 0.311 0.000265 90.6 PRS_PLINK_1e.05 369.5 Conjunctivitis, infectious Both 6 32 7 sense organs darkseagreen4 32, 6 7, 3 8, 1 8, 2 8, 0 -0.116 0.53 0.826 0.083 0.89 0.272 2.76 -0.706 1.61 0.661 0.18 0.493 0.00778 7.64 -0.532 1.53 0.728 0.138 0.588 0.00204 9.61 -1.06 1.57 0.497 0.304 0.345 0.00403 4.54 PRS_PLINK_1e.05 370 Keratitis Both 4 18 7 sense organs darkseagreen4 18, 4 5, 2 4, 0 4, 2 5, 0 -0.952 1.38 0.491 0.309 0.386 0.00111 5.69 1.47 3.57 0.68 0.167 4.36 0.00369 10300 -1.93 5.17 0.709 0.149 0.145 1.46e-05 423 -0.00456 3.34 0.999 0 0.995 0.000434 728 PRS_PLINK_1e.05 370.1 Corneal ulcer Both 0 6 7 sense organs darkseagreen4 6, 0 2 1 1 2 PRS_PLINK_1e.05 370.2 Superficial keratitis Both 2 7 7 sense organs darkseagreen4 7, 2 2, 1 2, 0 1, 1 2, 0 -0.389 269 0.999 0.001 0.678 0.228 0.825 -0.145 2440 1 0 0.865 0.301 1.39 -0.0014 115 1 0 0.999 0.921 1.12 0.0821 661 1 0 1.09 0.845 1.53 PRS_PLINK_1e.05 370.3 Keratoconjunctivitis Both 2 8 7 sense organs darkseagreen4 8, 2 2, 1 2, 0 2, 1 2, 0 -0.0318 1180 1 0 0.969 0.388 1.34 -0.703 8920 1 0 0.495 0.123 4.28 -0.0277 4280 1 0 0.973 0.213 1.75 -0.2 2900 1 0 0.819 0.35 1.6 PRS_PLINK_1e.05 370.31 Keratoconjunctivitis sicca Both 0 4 7 sense organs darkseagreen4 4, 0 1 1 1 1 PRS_PLINK_1e.05 371 Inflammation of the eye Both 11 35 7 sense organs darkseagreen4 35, 11 9, 4 9, 2 8, 5 9, 0 -0.2 0.401 0.618 0.209 0.819 0.387 1.72 -0.402 1.14 0.726 0.139 0.669 0.0627 5.02 1.73 1.51 0.252 0.599 5.66 0.546 57.8 -1.14 1.42 0.423 0.374 0.319 0.00121 3.59 PRS_PLINK_1e.05 371.1 Uveitis, noninfectious or NOS Both 2 9 7 sense organs darkseagreen4 9, 2 3, 1 2, 1 2, 0 2, 0 -0.0615 203 1 0 0.94 0.551 0.987 -0.0223 90.4 1 0 0.978 0.647 1.04 0.0598 1450 1 0 1.06 0.755 1.81 -0.00229 133 1 0 0.998 0.862 1.08 PRS_PLINK_1e.05 371.2 Conjunctivitis, noninfectious Both 1 16 7 sense organs darkseagreen4 16, 1 4, 0 4, 0 4, 1 4, 0 0.00805 1.11 0.994 0.003 1.01 0.0176 7.4 -0.473 25.5 0.985 0.006 0.623 0.652 0.793 PRS_PLINK_1e.05 371.21 Allergic conjunctivitis Both 1 15 7 sense organs darkseagreen4 15, 1 4, 0 4, 0 3, 1 4, 0 -0.0779 1.41 0.956 0.02 0.925 0.00794 10.6 0.48 564 0.999 0 1.62 0.237 9.59 PRS_PLINK_1e.05 371.3 Inflammation of eyelids Both 8 25 7 sense organs darkseagreen4 25, 8 7, 3 6, 1 6, 3 6, 1 -0.223 0.538 0.678 0.169 0.8 0.285 2.03 -0.782 1.63 0.631 0.2 0.458 0.00274 6.82 1.37 1.47 0.352 0.453 3.92 0.451 252 -0.105 1.47 0.943 0.026 0.9 0.0719 10.7 PRS_PLINK_1e.05 372 Disorders of conjunctiva Both 4 13 7 sense organs darkseagreen4 13, 4 4, 3 3, 1 3, 0 3, 0 -0.452 1.13 0.69 0.161 0.636 0.0513 4.06 -1.76 2.94 0.55 0.26 0.172 0.0017 15.3 -1.91 89.3 0.983 0.007 0.149 2.9e-06 126 -7.01 23.1 0.762 0.118 0.000907 0.00058 0.00144 PRS_PLINK_1e.05 374 Other disorders of eyelids Both 9 22 7 sense organs darkseagreen4 22, 9 6, 3 5, 0 5, 1 6, 5 0.288 0.59 0.625 0.204 1.33 0.473 4.63 -0.469 2.11 0.824 0.084 0.625 0.00103 13.8 1.22 3.07 0.689 0.161 3.4 0.0118 445000 0.229 1.31 0.862 0.065 1.26 0.129 13.6 PRS_PLINK_1e.05 374.1 Ectropion or entropion Both 1 5 7 sense organs darkseagreen4 5, 1 2, 0 1, 0 1, 0 1, 1 -9.55e-05 2090 1 0 1 0.614 2.02 -0.00131 177 1 0 0.999 0.84 1.07 PRS_PLINK_1e.05 374.2 Lagophthalmos Both 1 3 7 sense organs darkseagreen4 3, 1 1, 0 1, 1 1, 0 1, 0 -0.553 3200 1 0 0.575 0.0298 1.96 0.221 5830 1 0 1.25 0.306 1.5 PRS_PLINK_1e.05 374.3 Ptosis of eyelid Both 2 7 7 sense organs darkseagreen4 7, 2 2, 1 2, 1 1, 0 2, 0 0.12 6.16 0.984 0.007 1.13 1.1 1.2 -0.545 1570 1 0 0.58 0.309 2.46 -0.00476 365 1 0 0.995 0.739 1.4 -0.0533 1520 1 0 0.948 0.194 2.13 PRS_PLINK_1e.05 374.6 Dermatochalasis Both 1 9 7 sense organs darkseagreen4 9, 1 3, 1 2, 0 2, 0 2, 0 -0.0332 1610000 1 0 0.967 0.0754 14.2 -0.15 1280 1 0 0.86 0.0423 28.4 -8.55 8130000 1 0 0.000193 5.18e-15 11600000 0.00133 323 1 0 1 0.38 1.43 PRS_PLINK_1e.05 375 Disorders of lacrimal system Both 12 25 7 sense organs darkseagreen4 25, 12 7, 5 6, 4 6, 3 6, 0 -0.407 0.517 0.431 0.365 0.666 0.239 1.71 -1.05 1.5 0.486 0.313 0.351 0.00235 4.56 -0.0926 1.28 0.942 0.026 0.912 0.0262 16.9 2.39 3.03 0.429 0.367 10.9 0.0536 813000 PRS_PLINK_1e.05 375.1 Dry eyes Both 14 24 7 sense organs darkseagreen4 24, 14 6, 5 6, 3 6, 6 6, 0 -0.242 0.464 0.601 0.221 0.785 0.326 1.77 -0.639 1.85 0.73 0.137 0.528 0.000893 12.6 0.248 1.04 0.81 0.091 1.28 0.223 8.17 2.18 2.96 0.461 0.336 8.89 0.0674 1100000 PRS_PLINK_1e.05 375.2 Epiphora Both 1 7 7 sense organs darkseagreen4 7, 1 2, 1 2, 0 1, 0 2, 0 0.404 100 0.997 0.001 1.5 2.1 4.17 0.0201 159 1 0 1.02 0.908 1.17 5.97 6540 0.999 0 391 0.0272 3.85e+11 0.0318 233 1 0 1.03 0.794 1.25 PRS_PLINK_1e.05 376 Disorders of the orbit Both 1 4 7 sense organs darkseagreen4 4, 1 1, 1 1, 0 1, 0 1, 0 4.42 2.51e+08 1 0 82.8 5.76 4.52e+10 -0.0013 74.5 1 0 0.999 0.974 1.02 0.01 40.9 1 0 1.01 0.923 1.07 0.00146 92.3 1 0 1 0.973 1.02 PRS_PLINK_1e.05 377 Disorders of optic nerve and visual pathways Both 3 10 7 sense organs darkseagreen4 10, 3 2, 1 2, 0 2, 0 3, 2 0.973 1.96 0.62 0.208 2.65 0.144 4840 -0.247 3120 1 0 0.781 0.647 1.69 14.9 1990 0.994 0.003 2960000 2.49e-16 3.81e+30 0.284 18.4 0.988 0.005 1.33 0.0267 1.41 PRS_PLINK_1e.05 377.1 Optic atrophy Both 2 3 7 sense organs darkseagreen4 3, 2 1, 1 1, 0 0, 1 1, 0 -0.849 4650 1 0 0.428 0.0136 420 0.00539 25.1 1 0 1.01 0.96 1.06 21 1.53e+09 1 0 1.28e+09 2e-17 1.31e+33 -11.2 8.56e+08 1 0 1.35e-05 3.61e-18 10500000 PRS_PLINK_1e.05 377.3 Optic neuritis/neuropathy Both 2 5 7 sense organs darkseagreen4 5, 2 1, 1 1, 0 1, 0 1, 1 -0.031 142 1 0 0.969 0.849 1.58 0.0156 50.8 1 0 1.02 0.878 1.15 0.00445 1510 1 0 1 0.819 2.01 -8.72 17800 1 0 0.000163 1.32e-14 184000 PRS_PLINK_1e.05 378 Strabismus and other disorders of binocular eye movements Both 6 13 7 sense organs darkseagreen4 13, 6 4, 3 3, 1 3, 0 3, 2 -0.672 0.799 0.4 0.398 0.51 0.118 1.81 -2.4 3.63 0.508 0.294 0.0908 0.0797 6.34 -0.989 38.6 0.98 0.009 0.372 0.000265 63300 3.2 3.91 0.414 0.383 24.4 0.0834 8020 PRS_PLINK_1e.05 378.1 Strabismus (not specified as paralytic) Both 5 11 7 sense organs darkseagreen4 11, 5 3, 2 3, 1 2, 0 3, 2 0.0909 1.03 0.93 0.032 1.1 0.217 6.2 0.281 14.8 0.985 0.007 1.32 0.0136 6.94 -0.508 502 0.999 0 0.602 0.0304 16.3 1.31 14.1 0.925 0.034 3.72 0.0072 4.11 PRS_PLINK_1e.05 378.2 Nystagmus and other irregular eye movements Both 1 3 7 sense organs darkseagreen4 3, 1 1, 1 1, 0 1, 0 1, 1 0.307 4900 1 0 1.36 0.316 6.91 -0.0213 529 1 0 0.979 0.819 1.07 0.221 4720 1 0 1.25 0.581 6.92 PRS_PLINK_1e.05 378.5 Paralytic strabismus Both 1 3 7 sense organs darkseagreen4 3, 1 1, 1 1, 0 1, 0 1, 1 0.0345 2170 1 0 1.04 0.655 1.7 -0.00058 45.4 1 0 0.999 0.999 1 0.00178 69.7 1 0 1 0.979 1.05 PRS_PLINK_1e.05 379 Other disorders of eye Both 19 26 7 sense organs darkseagreen4 26, 19 7, 7 6, 3 6, 7 7, 2 -0.284 0.389 0.465 0.332 0.753 0.359 1.48 -0.58 1.16 0.618 0.209 0.56 0.0606 4.27 2.01 1.41 0.153 0.814 7.45 0.646 162 -0.413 1.08 0.701 0.154 0.661 0.101 4.19 PRS_PLINK_1e.05 379.1 Scleritis and episcleritis Both 0 3 7 sense organs darkseagreen4 3, 0 1 1 1 1 PRS_PLINK_1e.05 379.2 Disorders of vitreous body Both 16 16 7 sense organs darkseagreen4 16, 16 4, 7 4, 3 4, 5 4, 1 -0.555 0.563 0.324 0.489 0.574 0.186 1.47 -0.795 1.4 0.569 0.245 0.452 0.0351 4.57 0.403 1.11 0.716 0.145 1.5 0.254 11.7 -0.188 1.94 0.923 0.035 0.829 0.0361 30.3 PRS_PLINK_1e.05 379.3 Aphakia and other disorders of lens Both 0 5 7 sense organs darkseagreen4 5, 0 2 1 1 1 PRS_PLINK_1e.05 379.4 Anomalies of pupillary function Both 1 2 7 sense organs darkseagreen4 2, 1 1, 1 1, 0 1, 1 1, 0 0.000478 476 1 0 1 0.649 1.37 0.000835 51.7 1 0 1 0.988 1.01 PRS_PLINK_1e.05 379.5 Disorders of iris and ciliary body Both 0 3 7 sense organs darkseagreen4 3, 0 1 1 1 1 PRS_PLINK_1e.05 379.9 Pain, swelling or discharge of eye Both 6 18 7 sense organs darkseagreen4 18, 6 5, 3 4, 1 4, 0 5, 2 -0.373 0.699 0.594 0.226 0.689 0.164 2.17 -2.32 3.32 0.484 0.315 0.0979 0.00377 7.1 1.15 3.43 0.737 0.132 3.16 7.01e-06 2690 -1.59 2 0.427 0.369 0.204 0.00649 4.16 PRS_PLINK_1e.05 380 Disorders of external ear Both 6 22 7 sense organs darkseagreen4 22, 6 6, 2 5, 1 5, 1 6, 2 -0.294 0.611 0.631 0.2 0.745 0.228 2.13 -0.395 1.87 0.833 0.079 0.674 0.0169 12.7 -4.21 6.3 0.504 0.298 0.0148 1.69e-07 1070000 -0.321 1.34 0.811 0.091 0.725 0.000197 14.3 PRS_PLINK_1e.05 380.1 Otitis externa Both 2 26 7 sense organs darkseagreen4 26, 2 7, 0 6, 1 6, 1 7, 0 0.524 0.816 0.521 0.283 1.69 0.347 69.1 -0.369 2.94 0.9 0.046 0.691 9.18e-05 279 -0.00228 103 1 0 0.998 0.871 1.07 PRS_PLINK_1e.05 380.4 Impacted cerumen Both 6 28 7 sense organs darkseagreen4 28, 6 7, 2 7, 0 7, 2 7, 2 -0.214 0.574 0.71 0.149 0.808 0.243 2.25 -0.631 1.71 0.712 0.148 0.532 0.00489 9.67 0.35 2.15 0.87 0.06 1.42 0.022 72.6 0.0935 1.51 0.95 0.022 1.1 0.0576 13.3 PRS_PLINK_1e.05 381 Otitis media and Eustachian tube disorders Both 7 50 7 sense organs darkseagreen4 50, 7 12, 0 12, 2 12, 4 13, 1 0.365 0.516 0.48 0.319 1.44 0.543 5.49 0.23 1.3 0.86 0.066 1.26 0.0446 157 1.49 1.28 0.246 0.609 4.43 0.47 461 -0.454 1.76 0.797 0.099 0.635 2.27e-05 135 PRS_PLINK_1e.05 381.1 Otitis media Both 5 45 7 sense organs darkseagreen4 45, 5 11, 0 11, 2 11, 2 11, 1 0.114 0.533 0.831 0.08 1.12 0.359 4.26 0.00464 1.36 0.997 0.001 1 0.0221 64.5 1.49 1.49 0.317 0.499 4.45 0.342 8460 -0.314 1.86 0.866 0.062 0.731 0.000335 9890 PRS_PLINK_1e.05 381.11 Suppurative and unspecified otitis media Both 4 37 7 sense organs darkseagreen4 37, 4 9, 0 9, 2 9, 2 9, 0 0.0537 0.569 0.925 0.034 1.06 0.348 5.75 0.122 1.43 0.932 0.031 1.13 0.0421 53.7 1.16 1.56 0.457 0.34 3.19 0.264 53300000 PRS_PLINK_1e.05 381.2 Eustachian tube disorders Both 4 31 7 sense organs darkseagreen4 31, 4 8, 0 8, 0 7, 3 8, 1 0.612 0.789 0.438 0.358 1.84 0.381 223 1.66 2.04 0.418 0.379 5.23 0.109 6130 -0.49 2.03 0.809 0.092 0.613 0.00374 63.5 PRS_PLINK_1e.05 381.3 Mastoiditis & related conditions Both 0 5 7 sense organs darkseagreen4 5, 0 2 1 1 1 PRS_PLINK_1e.05 381.9 Otorrhea Both 0 5 7 sense organs darkseagreen4 5, 0 2 1 1 1 PRS_PLINK_1e.05 382 Otalgia Both 4 29 7 sense organs darkseagreen4 29, 4 8, 1 7, 2 7, 1 7, 0 -0.518 0.836 0.535 0.271 0.595 0.00458 3.33 -0.492 1.51 0.745 0.128 0.612 0.0398 8.43 0.367 1.92 0.849 0.071 1.44 0.0189 108 0.387 1.87 0.836 0.078 1.47 0.0524 149 PRS_PLINK_1e.05 383 Otosclerosis Both 0 4 7 sense organs darkseagreen4 4, 0 1 1 1 1 PRS_PLINK_1e.05 384 Other disorders of tympanic membrane Both 1 5 7 sense organs darkseagreen4 5, 1 2, 0 1, 0 1, 0 1, 1 0.0886 3560 1 0 1.09 0.00474 6.46 -0.353 5700 1 0 0.703 0.584 18.6 PRS_PLINK_1e.05 384.1 Myringitis Both 0 2 7 sense organs darkseagreen4 2, 0 1 1 1 1 PRS_PLINK_1e.05 384.4 Perforation of tympanic membrane Both 1 1 7 sense organs darkseagreen4 1, 1 21.8 1.56e+10 1 0 3e+09 1.8e-18 6.98e+41 PRS_PLINK_1e.05 385 Other disorders of middle ear and mastoid Both 0 6 7 sense organs darkseagreen4 6, 0 2 1 1 2 PRS_PLINK_1e.05 385.3 Cholesteatoma Both 0 4 7 sense organs darkseagreen4 4, 0 1 1 1 1 PRS_PLINK_1e.05 385.5 Tympanosclerosis and middle ear disease related to otitis media Both 0 3 7 sense organs darkseagreen4 3, 0 1 1 1 1 PRS_PLINK_1e.05 386 Vertiginous syndromes and other disorders of vestibular system Both 4 23 7 sense organs darkseagreen4 23, 4 5, 2 6, 0 5, 1 6, 1 0.13 0.665 0.845 0.073 1.14 0.303 6.21 -0.909 1.63 0.576 0.239 0.403 0.0283 6.81 -0.707 2.06 0.731 0.136 0.493 0.0135 14.8 0.0957 2.19 0.965 0.015 1.1 0.000355 50.8 PRS_PLINK_1e.05 386.1 Meniere's disease Both 0 2 7 sense organs darkseagreen4 2, 0 1 1 1 1 PRS_PLINK_1e.05 386.2 Peripheral or central vertigo Both 4 17 7 sense organs darkseagreen4 17, 4 5, 2 4, 0 4, 1 4, 1 0.281 0.818 0.731 0.136 1.32 0.301 118 1.95 11.4 0.864 0.064 7.02 6 8.14 -0.371 2.31 0.872 0.059 0.69 0.026 32.7 -1.52 3.44 0.658 0.182 0.218 0.000593 102 PRS_PLINK_1e.05 386.21 Central origin vertigo Both 3 14 7 sense organs darkseagreen4 14, 3 4, 2 3, 0 3, 1 4, 0 -0.637 0.973 0.513 0.29 0.529 0.0711 2.47 -0.22 577 1 0 0.802 0.541 1.59 0.34 32.4 0.992 0.004 1.4 0.106 20 -1.36 4.48 0.761 0.119 0.256 0.000341 171 PRS_PLINK_1e.05 386.3 Labyrinthitis Both 3 19 7 sense organs darkseagreen4 19, 3 4, 2 5, 0 4, 1 5, 0 -0.733 0.844 0.385 0.414 0.481 0.0553 3.02 -1.82 10.9 0.867 0.062 0.162 9.14e-09 669000 -0.773 22.1 0.972 0.012 0.461 0.445 0.478 -2.4 6.65 0.718 0.144 0.0904 2.46e-07 6720 PRS_PLINK_1e.05 386.9 Dizziness and giddiness (Light-headedness and vertigo) Both 12 46 7 sense organs darkseagreen4 46, 12 12, 2 11, 5 11, 3 12, 2 0.177 0.412 0.667 0.176 1.19 0.547 2.78 0.071 1.01 0.944 0.025 1.07 0.169 7.14 -1.14 1.37 0.407 0.39 0.321 0.00343 3.73 -0.166 1.47 0.91 0.041 0.847 0.0397 19.9 PRS_PLINK_1e.05 388 Other disorders of ear Both 0 7 7 sense organs darkseagreen4 7, 0 2 2 1 2 PRS_PLINK_1e.05 389 Hearing loss Both 13 49 7 sense organs darkseagreen4 49, 13 12, 3 12, 1 12, 5 12, 4 0.216 0.401 0.59 0.229 1.24 0.568 2.72 -1.13 1.72 0.512 0.291 0.324 0.000364 125 0.287 1.15 0.804 0.095 1.33 0.129 24.2 1.06 1.17 0.366 0.436 2.87 0.387 37.6 PRS_PLINK_1e.05 389.1 Sensorineural hearing loss Both 7 26 7 sense organs darkseagreen4 26, 7 7, 2 6, 1 6, 3 7, 1 -0.228 0.614 0.71 0.149 0.796 0.108 2.65 -0.925 2.04 0.651 0.187 0.397 0.00157 39.8 0.405 1.66 0.807 0.093 1.5 0.0654 47.1 -0.394 1.81 0.828 0.082 0.675 0.0314 155 PRS_PLINK_1e.05 389.2 Conductive hearing loss Both 1 11 7 sense organs darkseagreen4 11, 1 3, 0 3, 0 2, 0 3, 1 -0.579 2.54 0.82 0.086 0.56 0.527 71.2 -0.624 50500000 1 0 0.536 4.95e-05 1730 PRS_PLINK_1e.05 389.3 Degenerative and vascular disorders of ear Both 0 2 7 sense organs darkseagreen4 2, 0 1 1 1 1 PRS_PLINK_1e.05 389.4 Tinnitus Both 5 27 7 sense organs darkseagreen4 27, 5 7, 0 7, 1 6, 2 7, 2 0.444 0.606 0.464 0.333 1.56 0.542 5.75 0.37 1.73 0.831 0.081 1.45 0.0102 68.9 1.07 1.62 0.509 0.294 2.92 0.123 99.9 -0.0812 2.03 0.968 0.014 0.922 0.00114 414 PRS_PLINK_1e.05 389.5 Disorders of acoustic nerve Both 0 1 7 sense organs darkseagreen4 1, 0 PRS_PLINK_1e.05 394 Rheumatic disease of the heart valves Both 1 8 8 circulatory system red 8, 1 2, 1 2, 0 2, 0 2, 0 0.204 26.7 0.994 0.003 1.23 0.0148 69.3 -0.0519 2610 1 0 0.949 0.348 3.19 0.188 2190 1 0 1.21 0.659 1.49 0.219 2520 1 0 1.24 0.559 1.64 PRS_PLINK_1e.05 394.1 Mitral valve stenosis and aortic valve stenosis Both 1 1 8 circulatory system red 1, 1 0.00958 64.6 1 0 1.01 0.851 1.12 PRS_PLINK_1e.05 394.2 Mitral valve disease Both 0 3 8 circulatory system red 3, 0 1 1 1 1 PRS_PLINK_1e.05 394.7 Disease of tricuspid valve Both 0 2 8 circulatory system red 2, 0 1 1 1 1 PRS_PLINK_1e.05 395 Heart valve disorders Both 4 31 8 circulatory system red 31, 4 8, 1 8, 1 7, 1 8, 1 0.187 0.495 0.706 0.151 1.21 0.482 3.31 1.11 2.46 0.654 0.185 3.02 9.84e-05 9730 -0.721 1.59 0.65 0.187 0.486 4.51e-07 12.2 0.23 1.59 0.885 0.053 1.26 0.0122 7850 PRS_PLINK_1e.05 395.1 Nonrheumatic mitral valve disorders Both 2 18 8 circulatory system red 18, 2 5, 1 4, 0 4, 1 5, 0 -0.347 1.06 0.744 0.128 0.707 0.00264 9.97 -0.276 4.96 0.956 0.02 0.759 0.000179 1010 -0.988 3.07 0.748 0.126 0.372 0.00321 30.2 -0.102 2.58 0.969 0.014 0.903 0.000662 63.3 PRS_PLINK_1e.05 395.2 Nonrheumatic aortic valve disorders Both 2 14 8 circulatory system red 14, 2 4, 0 3, 1 3, 0 4, 1 0.118 0.891 0.895 0.048 1.13 0.144 7.14 0.537 1640000 1 0 1.71 0.575 7.03 -2.81 220 0.99 0.004 0.0599 5.59e-05 2700 PRS_PLINK_1e.05 395.3 Nonrheumatic tricuspid valve disorders Both 0 4 8 circulatory system red 4, 0 1 1 1 1 PRS_PLINK_1e.05 395.4 Nonrheumatic pulmonary valve disorders Both 0 2 8 circulatory system red 2, 0 1 1 1 1 PRS_PLINK_1e.05 395.6 Heart valve replaced Both 0 9 8 circulatory system red 9, 0 3 2 2 2 PRS_PLINK_1e.05 396 Abnormal heart sounds Both 4 45 8 circulatory system red 45, 4 12, 1 11, 0 11, 2 11, 1 0.279 0.503 0.579 0.237 1.32 0.492 4.26 -0.11 1.57 0.944 0.025 0.896 0.0034 48.9 0.498 1.29 0.699 0.156 1.65 0.0698 31.3 1.36 1.68 0.417 0.38 3.9 0.0644 2830000 PRS_PLINK_1e.05 401 Hypertension Both 29 35 8 circulatory system red 35, 29 8, 10 9, 9 8, 6 9, 4 -0.324 0.32 0.311 0.508 0.723 0.392 1.3 0.682 1 0.498 0.303 1.98 0.351 17.4 -0.663 0.954 0.487 0.313 0.515 0.0815 2.66 -1.3 1.13 0.251 0.601 0.273 0.0201 1.91 PRS_PLINK_1e.05 401.1 Essential hypertension Both 29 35 8 circulatory system red 35, 29 8, 10 9, 9 8, 6 9, 4 -0.324 0.32 0.311 0.508 0.723 0.392 1.3 0.682 1 0.498 0.303 1.98 0.351 17.4 -0.663 0.954 0.487 0.313 0.515 0.0815 2.66 -1.3 1.13 0.251 0.601 0.273 0.0201 1.91 PRS_PLINK_1e.05 401.2 Hypertensive heart and/or renal disease Both 1 19 8 circulatory system red 19, 1 5, 1 5, 0 4, 0 5, 0 -0.0834 0.826 0.92 0.036 0.92 0.0968 5.19 0.676 4.39 0.878 0.057 1.97 0.000218 1990 0.979 88.3 0.991 0.004 2.66 2.51 2.83 1.87 3.72 0.616 0.21 6.46 0.0378 7.54 PRS_PLINK_1e.05 401.21 Hypertensive heart disease Both 0 7 8 circulatory system red 7, 0 2 2 1 2 PRS_PLINK_1e.05 401.22 Hypertensive chronic kidney disease Both 1 18 8 circulatory system red 18, 1 5, 1 4, 0 4, 0 5, 0 0.104 0.933 0.911 0.041 1.11 0.103 6.74 0.67 4.43 0.88 0.056 1.95 0.00154 1380 0.979 88.3 0.991 0.004 2.66 2.51 2.83 1.87 3.72 0.616 0.21 6.46 0.0378 7.54 PRS_PLINK_1e.05 401.3 Other hypertensive complications Both 5 23 8 circulatory system red 23, 5 6, 1 6, 1 5, 2 6, 1 0.688 0.857 0.422 0.375 1.99 0.37 458 -1.31 3.02 0.665 0.177 0.271 3.99e-06 166 1.01 2.76 0.716 0.145 2.73 0.000167 28300 0.87 2.13 0.683 0.165 2.39 0.0829 1180 PRS_PLINK_1e.05 411 Ischemic Heart Disease Both 13 34 8 circulatory system red 34, 13 9, 1 8, 4 8, 3 9, 5 0.342 0.404 0.397 0.401 1.41 0.682 3.26 -0.246 1.46 0.866 0.062 0.782 0.00478 71.1 0.354 1.34 0.792 0.101 1.42 0.126 92.7 1.08 1.11 0.333 0.478 2.94 0.482 30 PRS_PLINK_1e.05 411.1 Unstable angina (intermediate coronary syndrome) Both 0 12 8 circulatory system red 12, 0 3 3 3 3 PRS_PLINK_1e.05 411.2 Myocardial infarction Both 5 25 8 circulatory system red 25, 5 7, 0 6, 1 6, 3 6, 1 0.454 0.629 0.47 0.328 1.57 0.504 7.42 1.05 2.17 0.628 0.202 2.86 0.0752 21900 1.52 1.84 0.41 0.387 4.55 0.261 1130 0.638 1.89 0.736 0.133 1.89 0.000491 773 PRS_PLINK_1e.05 411.3 Angina pectoris Both 3 22 8 circulatory system red 22, 3 6, 0 5, 1 5, 0 6, 2 0.599 0.746 0.422 0.375 1.82 0.292 18.1 -0.555 2.91 0.849 0.071 0.574 0.00151 205 0.0948 2.25 0.966 0.015 1.1 0.0358 196 PRS_PLINK_1e.05 411.4 Coronary atherosclerosis Both 7 31 8 circulatory system red 31, 7 8, 1 8, 3 7, 0 8, 3 -0.0335 0.519 0.948 0.023 0.967 0.297 3.09 -0.00138 1.49 0.999 0 0.999 0.00542 487 -0.624 1.57 0.691 0.16 0.536 0.0251 24.1 0.265 1.42 0.852 0.069 1.3 0.0281 39.9 PRS_PLINK_1e.05 411.41 Aneurysm and dissection of heart Both 0 3 8 circulatory system red 3, 0 1 1 1 1 PRS_PLINK_1e.05 411.8 Other chronic ischemic heart disease, unspecified Both 7 30 8 circulatory system red 30, 7 8, 1 7, 1 7, 4 8, 1 0.598 0.543 0.271 0.566 1.82 0.713 7.12 0.174 1.5 0.908 0.042 1.19 0.0443 30.2 3.15 2.08 0.129 0.888 23.4 0.878 57600 -0.376 1.61 0.816 0.089 0.687 0.013 89.1 PRS_PLINK_1e.05 411.9 Other acute and subacute forms of ischemic heart disease Both 0 4 8 circulatory system red 4, 0 1 1 1 1 PRS_PLINK_1e.05 414 Other forms of chronic heart disease Both 4 26 8 circulatory system red 26, 4 7, 2 6, 1 6, 0 7, 1 0.348 0.558 0.533 0.274 1.42 0.465 6.82 0.768 1.76 0.663 0.178 2.15 0.0637 3000 -1.79 2.41 0.459 0.338 0.168 0.000511 7.49 0.404 1.59 0.8 0.097 1.5 0.0419 580 PRS_PLINK_1e.05 414.2 ASCVD Both 1 10 8 circulatory system red 10, 1 3, 0 2, 0 2, 0 3, 1 0.099 2.68 0.971 0.013 1.1 0.00111 1370 -0.0913 803 1 0 0.913 0.322 7.15 PRS_PLINK_1e.05 415 Pulmonary heart disease Both 4 33 8 circulatory system red 33, 4 9, 1 8, 1 8, 0 8, 2 -0.124 0.57 0.828 0.082 0.884 0.26 2.73 0.952 1.66 0.565 0.248 2.59 0.0892 358 -0.203 1.61 0.9 0.046 0.816 0.013 53.4 0.567 1.37 0.679 0.168 1.76 0.0832 52800 PRS_PLINK_1e.05 415.1 Acute pulmonary heart disease Both 1 19 8 circulatory system red 19, 1 5, 0 5, 0 4, 0 5, 1 0.327 0.79 0.679 0.168 1.39 0.266 8.22 1.98 3.27 0.544 0.264 7.26 0.0957 2340 PRS_PLINK_1e.05 415.11 Pulmonary embolism and infarction, acute Both 1 19 8 circulatory system red 19, 1 5, 0 5, 0 4, 0 5, 1 0.327 0.79 0.679 0.168 1.39 0.266 8.22 1.98 3.27 0.544 0.264 7.26 0.0957 2340 PRS_PLINK_1e.05 415.2 Chronic pulmonary heart disease Both 4 20 8 circulatory system red 20, 4 5, 0 5, 2 5, 0 5, 2 0.685 0.711 0.335 0.475 1.98 0.563 19.2 0.331 2.22 0.881 0.055 1.39 0.0103 90.6 0.839 2.25 0.71 0.149 2.31 0.084 66.1 PRS_PLINK_1e.05 415.21 Primary pulmonary hypertension Both 3 9 8 circulatory system red 9, 3 3, 0 2, 2 2, 0 2, 1 0.161 2.46 0.948 0.023 1.17 0.00295 20.7 0.476 2190 1 0 1.61 0.0179 51.4 -1.72 19000 1 0 0.179 0.143 30.2 PRS_PLINK_1e.05 416 Cardiomegaly Both 1 15 8 circulatory system red 15, 1 4, 1 4, 0 3, 0 4, 0 -0.746 1.4 0.594 0.226 0.474 0.0065 10.2 -0.0626 930 1 0 0.939 0.424 1.5 -0.32 2020 1 0 0.726 0.166 11.6 -0.975 10200000 1 0 0.377 0.0112 2300 PRS_PLINK_1e.05 418 Nonspecific chest pain Both 28 35 8 circulatory system red 35, 28 8, 5 9, 8 8, 7 9, 8 0.033 0.331 0.92 0.036 1.03 0.555 1.92 -1.32 1.25 0.291 0.536 0.267 0.0213 2.19 0.47 0.996 0.637 0.196 1.6 0.274 10.9 -0.16 1.18 0.892 0.049 0.852 0.0874 8.07 PRS_PLINK_1e.05 418.1 Precordial pain Both 4 12 8 circulatory system red 12, 4 3, 3 3, 1 3, 0 3, 0 -0.0837 0.927 0.928 0.032 0.92 0.161 4.83 -1.16 20 0.954 0.021 0.314 0.000103 0.362 -2.69 22.6 0.905 0.043 0.0679 0.00422 0.00111 -0.69 48.6 0.989 0.005 0.502 0.0174 10.9 PRS_PLINK_1e.05 420 Carditis Both 1 16 8 circulatory system red 16, 1 4, 1 4, 0 4, 0 4, 0 -0.32 0.916 0.727 0.138 0.726 0.075 7.32 0.142 19.2 0.994 0.003 1.15 0.000112 13900 -0.0242 75.5 1 0 0.976 0.311 2.46 -0.0956 12300000 1 0 0.909 0.000182 113 PRS_PLINK_1e.05 420.2 Pericarditis Both 1 7 8 circulatory system red 7, 1 2, 1 2, 0 1, 0 2, 0 -0.253 437 1 0 0.777 0.904 0.993 -0.0495 969 1 0 0.952 0.644 1.26 -0.019 328 1 0 0.981 0.791 1.19 1.8 12600 1 0 6.03 0.0119 584 PRS_PLINK_1e.05 420.21 Acute pericarditis Both 1 3 8 circulatory system red 3, 1 1, 0 1, 1 1, 0 1, 0 -0.288 3660 1 0 0.75 0.00544 2.31 -0.0117 17.2 0.999 0 0.988 0.874 1.28 PRS_PLINK_1e.05 420.22 Chronic pericarditis Both 1 0 8 circulatory system red 0, 1 PRS_PLINK_1e.05 420.3 Endocarditis Both 0 9 8 circulatory system red 9, 0 3 2 2 2 PRS_PLINK_1e.05 425 Cardiomyopathy Both 3 19 8 circulatory system red 19, 3 5, 1 5, 0 4, 2 5, 0 0.147 0.793 0.853 0.069 1.16 0.181 10.5 -0.0806 1.78 0.964 0.016 0.923 0.049 19.2 -0.157 6.97 0.982 0.008 0.854 0.00831 94 0.221 2.13 0.917 0.037 1.25 0.00446 63 PRS_PLINK_1e.05 425.1 Primary/intrinsic cardiomyopathies Both 3 19 8 circulatory system red 19, 3 5, 1 5, 0 4, 2 5, 0 0.147 0.793 0.853 0.069 1.16 0.181 10.5 -0.0806 1.78 0.964 0.016 0.923 0.049 19.2 -0.157 6.97 0.982 0.008 0.854 0.00831 94 0.221 2.13 0.917 0.037 1.25 0.00446 63 PRS_PLINK_1e.05 425.11 Hypertrophic obstructive cardiomyopathy Both 0 1 8 circulatory system red 1, 0 PRS_PLINK_1e.05 425.12 Other hypertrophic cardiomyopathy Both 0 1 8 circulatory system red 1, 0 PRS_PLINK_1e.05 425.2 Secondary/extrinsic cardiomyopathies Both 0 2 8 circulatory system red 2, 0 1 1 1 1 PRS_PLINK_1e.05 425.8 Other cardiomyopathy Both 0 1 8 circulatory system red 1, 0 PRS_PLINK_1e.05 426 Cardiac conduction disorders Both 17 33 8 circulatory system red 33, 17 8, 2 8, 7 8, 6 8, 2 -0.0242 0.36 0.946 0.024 0.976 0.502 1.94 -0.00887 1.17 0.994 0.003 0.991 0.104 7.79 0.938 1.33 0.481 0.318 2.56 0.294 39.2 -0.299 1.29 0.816 0.088 0.742 0.0117 6.81 PRS_PLINK_1e.05 426.2 Atrioventricular [AV] block Both 0 12 8 circulatory system red 12, 0 3 3 3 3 PRS_PLINK_1e.05 426.21 First degree AV block Both 0 10 8 circulatory system red 10, 0 3 2 2 3 PRS_PLINK_1e.05 426.23 Second degree AV block Both 0 2 8 circulatory system red 2, 0 1 1 1 1 PRS_PLINK_1e.05 426.24 Atrioventricular block, complete Both 0 3 8 circulatory system red 3, 0 1 1 1 1 PRS_PLINK_1e.05 426.25 Other heart block Both 0 2 8 circulatory system red 2, 0 1 1 1 1 PRS_PLINK_1e.05 426.3 Bundle branch block Both 2 16 8 circulatory system red 16, 2 4, 2 4, 0 4, 0 4, 0 -0.746 0.802 0.352 0.453 0.474 0.0282 2.38 0.426 3.65 0.907 0.042 1.53 0.0021 262 -1.93 2.39 0.419 0.378 0.145 0.00266 3.14 -0.429 2.12 0.84 0.076 0.651 0.0179 13 PRS_PLINK_1e.05 426.31 Right bundle branch block Both 2 7 8 circulatory system red 7, 2 2, 1 2, 1 1, 0 2, 0 0.0187 966 1 0 1.02 0.721 1.48 0.0261 4150 1 0 1.03 0.314 2.55 0.00658 447 1 0 1.01 0.84 1.33 0.037 2290 1 0 1.04 0.507 2.27 PRS_PLINK_1e.05 426.32 Left bundle branch block Both 0 11 8 circulatory system red 11, 0 3 3 2 3 PRS_PLINK_1e.05 426.4 Anomalous atrioventricular excitation Both 0 1 8 circulatory system red 1, 0 PRS_PLINK_1e.05 426.7 Abnormal electrocardiogram [ECG] [EKG] Both 16 31 8 circulatory system red 31, 16 8, 2 8, 6 7, 6 8, 2 -0.0273 0.403 0.946 0.024 0.973 0.461 2.06 -0.126 1.21 0.917 0.038 0.881 0.0801 7.15 0.933 1.33 0.483 0.316 2.54 0.287 39.1 -0.299 1.29 0.816 0.088 0.742 0.0117 6.81 PRS_PLINK_1e.05 426.8 Other cardiac conduction disorders Both 0 5 8 circulatory system red 5, 0 2 1 1 1 PRS_PLINK_1e.05 426.9 Cardiac pacemaker/device in situ Both 1 11 8 circulatory system red 11, 1 3, 1 3, 0 2, 0 3, 0 -0.297 1.14 0.794 0.1 0.743 0.0348 4.63 0.0897 3270 1 0 1.09 0.667 2.85 -0.214 4080 1 0 0.807 0.262 2.23 -0.0294 12100000 1 0 0.971 0.337 3.76 PRS_PLINK_1e.05 426.91 Cardiac pacemaker in situ Both 0 4 8 circulatory system red 4, 0 1 1 1 1 PRS_PLINK_1e.05 426.92 Cardiac defibrillator in situ Both 0 6 8 circulatory system red 6, 0 2 1 1 2 PRS_PLINK_1e.05 427 Cardiac dysrhythmias Both 25 33 8 circulatory system red 33, 25 8, 6 8, 7 8, 11 8, 1 -0.176 0.329 0.593 0.227 0.839 0.447 1.53 -0.00681 1.1 0.995 0.002 0.993 0.126 7.77 0.643 0.98 0.512 0.291 1.9 0.359 13.6 -0.77 1.4 0.582 0.235 0.463 0.012 7.64 PRS_PLINK_1e.05 427.1 Paroxysmal tachycardia, unspecified Both 4 22 8 circulatory system red 22, 4 5, 1 5, 1 5, 2 6, 0 -0.211 0.548 0.701 0.155 0.81 0.179 2.46 0.391 1.75 0.823 0.085 1.48 0.0389 38 -0.176 1.54 0.909 0.042 0.839 0.115 10.1 -0.0822 1.66 0.961 0.017 0.921 0.025 18.5 PRS_PLINK_1e.05 427.11 Paroxysmal supraventricular tachycardia Both 2 14 8 circulatory system red 14, 2 4, 1 3, 1 3, 0 4, 0 -0.7 1.01 0.49 0.31 0.497 0.028 2.67 4.31 1.8e+07 1 0 74.2 1.15 88700 -0.421 2840 1 0 0.656 0.481 0.501 -0.463 223 0.998 0.001 0.63 8.73e-10 3560000 PRS_PLINK_1e.05 427.12 Paroxysmal ventricular tachycardia Both 2 10 8 circulatory system red 10, 2 3, 0 2, 0 2, 2 3, 0 -0.0136 1.41 0.992 0.003 0.987 0.0506 12.5 -0.849 1460 1 0 0.428 0.215 2.01 PRS_PLINK_1e.05 427.2 Atrial fibrillation and flutter Both 4 22 8 circulatory system red 22, 4 5, 1 5, 2 5, 1 6, 0 -0.869 0.748 0.245 0.611 0.419 0.0358 1.57 1.11 2.35 0.637 0.196 3.04 0.015 346 0.0772 1.56 0.961 0.017 1.08 0.0858 17.4 -0.589 1.57 0.707 0.151 0.555 0.0219 20.2 PRS_PLINK_1e.05 427.21 Atrial fibrillation Both 4 20 8 circulatory system red 20, 4 5, 1 5, 2 5, 0 5, 1 -0.876 0.829 0.291 0.537 0.416 0.0319 1.63 1.11 2.35 0.637 0.196 3.04 0.015 346 -0.772 2.58 0.765 0.117 0.462 0.0082 24 -0.171 1.56 0.913 0.04 0.843 0.0308 9.57 PRS_PLINK_1e.05 427.22 Atrial flutter Both 1 11 8 circulatory system red 11, 1 2, 0 3, 0 2, 0 3, 1 -0.213 1.13 0.851 0.07 0.808 0.111 4.86 -0.0581 2800 1 0 0.944 0.47 1.78 PRS_PLINK_1e.05 427.3 Other specified cardiac dysrhythmias Both 12 33 8 circulatory system red 33, 12 8, 4 8, 2 8, 6 8, 0 -0.0969 0.393 0.805 0.094 0.908 0.429 1.97 -0.0581 1.28 0.964 0.016 0.944 0.00381 10.6 0.85 1.18 0.471 0.327 2.34 0.323 35.4 -0.511 1.52 0.737 0.133 0.6 0.00516 23.1 PRS_PLINK_1e.05 427.4 Cardiac arrest and ventricular fibrillation Both 0 1 8 circulatory system red 1, 0 PRS_PLINK_1e.05 427.41 Ventricular fibrillation and flutter Both 0 1 8 circulatory system red 1, 0 PRS_PLINK_1e.05 427.42 Cardiac arrest Both 0 1 8 circulatory system red 1, 0 PRS_PLINK_1e.05 427.5 Arrhythmia (cardiac) NOS Both 5 32 8 circulatory system red 32, 5 7, 1 8, 1 8, 3 8, 0 -0.502 0.596 0.4 0.398 0.605 0.0536 2.3 -0.629 1.5 0.674 0.171 0.533 0.016 7.28 0.325 1.4 0.817 0.088 1.38 0.0402 130 -0.265 1.49 0.859 0.066 0.767 0.0281 256 PRS_PLINK_1e.05 427.6 Premature beats Both 4 19 8 circulatory system red 19, 4 5, 0 5, 2 4, 2 5, 0 -0.468 0.808 0.563 0.25 0.626 0.107 4.18 -0.52 3.47 0.881 0.055 0.595 0.000216 101 5.62e-13 5.46 1 0 1 0.000186 3230 PRS_PLINK_1e.05 427.61 Supraventricular premature beats Both 1 8 8 circulatory system red 8, 1 2, 0 2, 1 2, 0 2, 0 -0.128 408 1 0 0.88 0.763 1.15 -0.123 5500 1 0 0.884 0.0729 8.72 PRS_PLINK_1e.05 427.7 Tachycardia NOS Both 5 33 8 circulatory system red 33, 5 8, 0 8, 2 8, 2 8, 1 0.124 0.497 0.804 0.095 1.13 0.437 3.6 0.218 1.55 0.888 0.051 1.24 0.00851 53.5 -0.159 1.79 0.929 0.032 0.853 0.0057 76.7 0.044 1.45 0.976 0.011 1.04 0.026 102 PRS_PLINK_1e.05 427.8 Sinoatrial node dysfunction (Bradycardia) Both 0 6 8 circulatory system red 6, 0 2 1 1 2 PRS_PLINK_1e.05 427.9 Palpitations Both 9 31 8 circulatory system red 31, 9 7, 2 8, 3 7, 3 8, 1 -0.385 0.475 0.418 0.379 0.681 0.249 1.67 -0.00471 1.36 0.997 0.001 0.995 0.0707 12 0.463 1.63 0.777 0.11 1.59 0.116 38500 -0.815 1.46 0.576 0.24 0.443 0.0026 6.01 PRS_PLINK_1e.05 428 Congestive heart failure; nonhypertensive Both 3 20 8 circulatory system red 20, 3 5, 1 5, 0 5, 2 5, 0 0.152 0.794 0.848 0.072 1.16 0.113 8.03 -0.686 4.18 0.87 0.061 0.503 5.78e-05 1100 0.133 2.02 0.948 0.023 1.14 0.0418 63.7 0.0522 2.35 0.982 0.008 1.05 0.0226 50.7 PRS_PLINK_1e.05 428.1 Congestive heart failure (CHF) NOS Both 2 18 8 circulatory system red 18, 2 5, 1 4, 0 4, 1 5, 0 0.414 0.814 0.611 0.214 1.51 0.0309 10.5 -0.115 4.77 0.981 0.008 0.891 0.000731 1600 0.267 2.07 0.897 0.047 1.31 0.0543 61.7 1.28 6.31 0.839 0.076 3.59 0.000137 62100 PRS_PLINK_1e.05 428.2 Heart failure NOS Both 3 18 8 circulatory system red 18, 3 5, 1 4, 0 4, 2 5, 0 0.26 0.824 0.752 0.124 1.3 0.0673 8.36 -0.115 4.77 0.981 0.008 0.891 0.000731 1600 -1.12 3.91 0.776 0.11 0.328 0.000687 154 1.28 6.31 0.839 0.076 3.59 0.000137 62100 PRS_PLINK_1e.05 428.3 Heart failure with reduced EF [Systolic or combined heart failure] Both 2 9 8 circulatory system red 9, 2 3, 0 2, 0 2, 2 2, 0 -0.128 1.05 0.903 0.044 0.88 0.0224 28.7 0.459 2040 1 0 1.58 0.124 87 PRS_PLINK_1e.05 428.4 Heart failure with preserved EF [Diastolic heart failure] Both 1 11 8 circulatory system red 11, 1 3, 1 3, 0 2, 0 3, 0 -0.0743 1.68 0.965 0.016 0.928 0.0624 140 -0.0347 531 1 0 0.966 0.24 1.46 -0.00999 318 1 0 0.99 0.83 1.08 0.109 1010 1 0 1.12 0.518 3.32 PRS_PLINK_1e.05 429 Ill-defined descriptions and complications of heart disease Both 28 35 8 circulatory system red 35, 28 8, 8 9, 6 8, 13 9, 1 -0.235 0.311 0.45 0.347 0.791 0.44 1.4 -2.71 1.53 0.077 1.113 0.0667 0.000615 0.85 0.916 1.05 0.382 0.418 2.5 0.388 27.6 -2.12 1.58 0.18 0.745 0.121 0.00068 1.75 PRS_PLINK_1e.05 429.1 Heart transplant/surgery Both 2 5 8 circulatory system red 5, 2 2, 1 1, 0 1, 0 1, 1 0.0692 1140 1 0 1.07 0.699 1.82 0.0364 2470 1 0 1.04 0.757 3.36 -0.0175 1210 1 0 0.983 0.694 1.16 -0.00316 151 1 0 0.997 0.659 1.24 PRS_PLINK_1e.05 429.2 Abnormal function study of cardiovascular system Both 15 30 8 circulatory system red 30, 15 8, 4 7, 3 7, 8 8, 0 -0.321 0.382 0.4 0.398 0.725 0.355 1.43 -1.42 1.43 0.322 0.492 0.242 0.00356 2.3 0.749 0.938 0.425 0.372 2.11 0.433 13.2 -0.665 1.52 0.662 0.179 0.514 0.0102 25.3 PRS_PLINK_1e.05 429.3 Symptoms involving cardiovascular system Both 18 35 8 circulatory system red 35, 18 8, 5 9, 4 8, 8 9, 1 -0.238 0.384 0.536 0.271 0.788 0.375 1.63 -1.43 1.33 0.284 0.546 0.24 0.00714 2.37 0.301 1.24 0.808 0.093 1.35 0.149 16.3 -1.26 1.51 0.403 0.395 0.284 0.00217 7.12 PRS_PLINK_1e.05 429.9 Cardiac complications, not elsewhere classified Both 1 2 8 circulatory system red 2, 1 1, 0 1, 1 1, 0 1, 1 0.00402 21.5 1 0 1 0.987 1.07 -0.0077 21.3 1 0 0.992 0.975 1.03 PRS_PLINK_1e.05 430 Intracranial hemorrhage Both 1 11 8 circulatory system red 11, 1 3, 0 3, 0 2, 0 3, 1 0.928 10.4 0.929 0.032 2.53 1.87e-08 8.72e+08 -0.149 1340 1 0 0.862 0.138 1.44 PRS_PLINK_1e.05 430.1 Subarachnoid hemorrhage Both 0 4 8 circulatory system red 4, 0 1 1 1 1 PRS_PLINK_1e.05 430.2 Intracerebral hemorrhage Both 0 3 8 circulatory system red 3, 0 1 1 1 1 PRS_PLINK_1e.05 430.3 Subdural hemorrhage Both 0 3 8 circulatory system red 3, 0 1 1 1 1 PRS_PLINK_1e.05 433 Cerebrovascular disease Both 8 35 8 circulatory system red 35, 8 9, 3 9, 1 8, 2 9, 2 -0.263 0.452 0.562 0.251 0.769 0.292 1.78 -0.541 1.36 0.691 0.161 0.582 0.0109 7.32 -2.01 1.62 0.217 0.664 0.135 1.04e-07 2.48 -0.784 1.28 0.541 0.267 0.457 0.0199 11.6 PRS_PLINK_1e.05 433.1 Occlusion and stenosis of precerebral arteries Both 3 15 8 circulatory system red 15, 3 4, 1 4, 1 3, 0 4, 1 -0.173 0.983 0.86 0.066 0.841 0.24 8.44 -1.48 15.4 0.923 0.035 0.228 0.208 0.25 -1.2 15800000 1 0 0.301 3.77e-05 599 -2.48 6.12 0.685 0.164 0.0834 0.0723 0.0957 PRS_PLINK_1e.05 433.11 Occlusion of cerebral arteries, with cerebral infarction Both 1 2 8 circulatory system red 2, 1 1, 1 1, 0 1, 1 1, 0 -0.0241 54.1 1 0 0.976 0.897 1.08 0.0115 66.3 1 0 1.01 0.842 1.22 PRS_PLINK_1e.05 433.12 Cerebral atherosclerosis Both 0 1 8 circulatory system red 1, 0 PRS_PLINK_1e.05 433.2 Occlusion of cerebral arteries Both 2 24 8 circulatory system red 24, 2 6, 1 6, 0 6, 1 6, 0 -0.357 0.827 0.666 0.176 0.7 0.0308 8.16 -0.013 2.38 0.996 0.002 0.987 0.021 91.5 -1.77 3.44 0.607 0.217 0.17 1.48e-06 24.2 -0.0203 1.67 0.99 0.004 0.98 0.0489 2750 PRS_PLINK_1e.05 433.21 Cerebral artery occlusion, with cerebral infarction Both 2 23 8 circulatory system red 23, 2 6, 1 6, 0 5, 1 6, 0 -0.362 0.823 0.66 0.181 0.696 0.0405 7.99 -0.181 2.78 0.948 0.023 0.835 0.00467 204 -0.882 3.82 0.818 0.087 0.414 8.43e-07 156 -0.0203 1.67 0.99 0.004 0.98 0.0489 2750 PRS_PLINK_1e.05 433.3 Cerebral ischemia Both 5 25 8 circulatory system red 25, 5 7, 2 6, 1 6, 1 6, 1 -0.381 0.685 0.578 0.238 0.683 0.14 2.91 -0.74 2.08 0.722 0.141 0.477 0.00395 148 -0.798 2.99 0.79 0.103 0.45 5.51e-06 1480 0.256 1.4 0.855 0.068 1.29 0.121 89300 PRS_PLINK_1e.05 433.31 Transient cerebral ischemia Both 4 21 8 circulatory system red 21, 4 6, 2 5, 0 5, 1 5, 1 -0.109 0.708 0.877 0.057 0.896 0.124 18.1 -0.383 3.06 0.9 0.046 0.682 0.00242 2290 1.13 4.61 0.806 0.094 3.1 0.000679 30100 -0.0419 1.73 0.981 0.008 0.959 0.0109 24600 PRS_PLINK_1e.05 433.5 Cerebral aneurysm Both 1 8 8 circulatory system red 8, 1 2, 1 2, 0 2, 0 2, 0 -0.169 5.72 0.976 0.01 0.844 0.954 2.41 -0.0191 292 1 0 0.981 0.809 1.06 0.034 1810 1 0 1.03 0.577 1.55 0.0422 2070 1 0 1.04 0.497 1.88 PRS_PLINK_1e.05 433.6 Acute, but ill-defined cerebrovascular disease Both 0 6 8 circulatory system red 6, 0 2 1 1 2 PRS_PLINK_1e.05 433.8 Late effects of cerebrovascular disease Both 1 7 8 circulatory system red 7, 1 2, 1 2, 0 1, 0 2, 0 -0.792 1240 0.999 0 0.453 0.106 0.612 -0.029 2850 1 0 0.971 0.322 1.73 -0.0655 2020 1 0 0.937 0.396 1.43 0.0076 172 1 0 1.01 0.00669 684 PRS_PLINK_1e.05 440 Atherosclerosis Both 2 19 8 circulatory system red 19, 2 5, 1 5, 0 4, 1 5, 0 0.631 1.14 0.579 0.237 1.88 0.0224 19.5 -0.186 4.47 0.967 0.015 0.83 8.68e-07 4650 -8.24 15.9 0.604 0.219 0.000265 0.000167 257000 0.899 3.05 0.769 0.114 2.46 0.0192 490 PRS_PLINK_1e.05 440.1 Atherosclerosis of renal artery Both 0 2 8 circulatory system red 2, 0 1 1 1 1 PRS_PLINK_1e.05 440.2 Atherosclerosis of the extremities Both 2 16 8 circulatory system red 16, 2 4, 0 4, 1 4, 0 4, 1 0.523 1.35 0.699 0.156 1.69 0.0427 171 1 3.17 0.751 0.124 2.73 0.0203 405 -0.531 34.3 0.988 0.005 0.588 0.431 0.796 PRS_PLINK_1e.05 440.21 Atherosclerosis of native arteries of the extremities with ulceration or gangrene Both 0 9 8 circulatory system red 9, 0 3 2 2 2 PRS_PLINK_1e.05 440.22 Atherosclerosis of native arteries of the extremities with intermittent claudication Both 2 11 8 circulatory system red 11, 2 3, 1 3, 0 2, 1 3, 0 0.419 1.46 0.775 0.111 1.52 0.167 2.55 -0.212 5480000 1 0 0.809 0.299 3.17 -0.131 450 1 0 0.877 0.628 1.13 0.0855 942 1 0 1.09 0.528 6.48 PRS_PLINK_1e.05 440.9 Atherosclerosis of aorta Both 1 3 8 circulatory system red 3, 1 1, 1 1, 0 1, 0 1, 1 -0.000272 5580 1 0 1 0.453 6.15 -0.162 5670 1 0 0.851 0.263 1.45 0.124 1980 1 0 1.13 0.697 3.06 PRS_PLINK_1e.05 441 Vascular insufficiency of intestine Both 0 8 8 circulatory system red 8, 0 2 2 2 2 PRS_PLINK_1e.05 441.1 Acute vascular insufficiency of intestine Both 0 3 8 circulatory system red 3, 0 1 1 1 1 PRS_PLINK_1e.05 442 Other aneurysm Both 4 21 8 circulatory system red 21, 4 5, 1 5, 0 5, 2 5, 1 -0.351 0.681 0.607 0.217 0.704 0.655 2.72 -0.908 2.16 0.674 0.171 0.403 0.00598 21.6 -1.18 1.97 0.548 0.261 0.306 0.247 4.78 -1.93 2.31 0.403 0.395 0.144 0.00129 3.74 PRS_PLINK_1e.05 442.1 Aortic aneurysm Both 3 13 8 circulatory system red 13, 3 3, 0 3, 0 3, 2 3, 1 -0.175 1.35 0.897 0.047 0.839 0.0469 52.4 1.03 9860000 1 0 2.79 0.0902 20.2 0.06 1650 1 0 1.06 0.478 2.64 PRS_PLINK_1e.05 442.11 Abdominal aortic aneurysm Both 1 4 8 circulatory system red 4, 1 1, 0 1, 0 1, 0 1, 1 -2.88 4810 1 0 0.056 9.84e-08 5550000 -0.00428 49.1 1 0 0.996 0.909 1.1 PRS_PLINK_1e.05 442.3 Aneurysm of artery of lower extremity Both 0 2 8 circulatory system red 2, 0 1 1 1 1 PRS_PLINK_1e.05 442.4 Arterial dissection Both 1 0 8 circulatory system red 0, 1 PRS_PLINK_1e.05 442.8 Aneurysm of other specified artery Both 0 3 8 circulatory system red 3, 0 1 1 1 1 PRS_PLINK_1e.05 443 Peripheral vascular disease Both 3 28 8 circulatory system red 28, 3 7, 2 7, 0 7, 0 7, 1 -0.603 0.876 0.491 0.309 0.547 0.00684 2.91 -1.26 2.09 0.546 0.263 0.283 0.00289 31.9 -1.22 3.31 0.712 0.147 0.295 0.000564 542000 -0.121 1.73 0.944 0.025 0.886 0.000376 27.7 PRS_PLINK_1e.05 443.1 Raynaud's syndrome Both 1 7 8 circulatory system red 7, 1 2, 1 2, 0 1, 0 2, 0 0.0276 168 1 0 1.03 0.687 2.6 -0.175 3270 1 0 0.839 0.205 2.47 -0.00658 391 1 0 0.993 0.844 1.07 0.0226 389 1 0 1.02 0.939 1.2 PRS_PLINK_1e.05 443.7 Peripheral angiopathy in diseases classified elsewhere Both 1 5 8 circulatory system red 5, 1 2, 0 1, 0 1, 0 1, 1 0.04 6290000 1 0 1.04 0.388 1.66 0.00152 27600 1 0 1 0.108 1.56e+09 PRS_PLINK_1e.05 443.8 Other specified peripheral vascular diseases Both 3 27 8 circulatory system red 27, 3 7, 2 7, 0 6, 0 7, 1 -0.601 0.878 0.494 0.307 0.548 0.00649 2.93 -1.22 2.1 0.562 0.25 0.295 0.00356 159 -1.22 3.31 0.712 0.147 0.295 0.000564 542000 -0.121 1.73 0.944 0.025 0.886 0.000376 27.7 PRS_PLINK_1e.05 443.9 Peripheral vascular disease, unspecified Both 3 23 8 circulatory system red 23, 3 6, 2 6, 0 5, 0 6, 1 -1.21 1.09 0.268 0.572 0.299 0.00797 2.18 -2.62 3.68 0.477 0.322 0.0727 4.54e-06 57.5 -0.158 4.34 0.971 0.013 0.854 0.000136 9280000 0.567 1.71 0.741 0.13 1.76 0.0751 943 PRS_PLINK_1e.05 444 Arterial embolism and thrombosis Both 1 13 8 circulatory system red 13, 1 4, 0 3, 0 3, 1 3, 0 0.0844 1.37 0.951 0.022 1.09 0.0339 34.9 0.09 514 1 0 1.09 0.362 2.65 PRS_PLINK_1e.05 444.1 Arterial embolism and thrombosis of lower extremity artery Both 0 4 8 circulatory system red 4, 0 1 1 1 1 PRS_PLINK_1e.05 444.2 Embolism and thrombosis of abdominal aorta Both 0 1 8 circulatory system red 1, 0 PRS_PLINK_1e.05 446 Polyarteritis nodosa and allied conditions Both 1 10 8 circulatory system red 10, 1 3, 0 2, 1 2, 0 3, 0 0.858 9.5 0.928 0.032 2.36 5.36e-06 841000 -0.0464 5860 1 0 0.955 0.0262 4.81 PRS_PLINK_1e.05 446.4 Wegener's granulomatosis Both 0 3 8 circulatory system red 3, 0 1 1 1 1 PRS_PLINK_1e.05 446.5 Giant cell arteritis Both 1 1 8 circulatory system red 1, 1 -0.022 62.8 1 0 0.978 0.932 1.06 PRS_PLINK_1e.05 446.9 Arteritis NOS Both 1 4 8 circulatory system red 4, 1 1, 0 1, 0 1, 1 1, 0 -0.31 2020 1 0 0.733 0.611 1.46 -0.422 36000 1 0 0.656 0.486 10.7 PRS_PLINK_1e.05 447 Other disorders of arteries and arterioles Both 3 23 8 circulatory system red 23, 3 6, 1 6, 1 5, 0 6, 1 -0.845 0.922 0.359 0.444 0.43 0.0175 2.29 -1.39 3.11 0.654 0.184 0.248 0.00654 19.2 -1.77 2.28 0.437 0.359 0.17 0.000941 5.02 -1.77 2.04 0.386 0.413 0.171 0.000638 2.89 PRS_PLINK_1e.05 447.1 Stricture of artery Both 1 5 8 circulatory system red 5, 1 2, 0 1, 0 1, 0 1, 1 -0.167 1240 1 0 0.846 1.22 3.18 -2.92e-06 847 1 0 1 0.862 1.14 PRS_PLINK_1e.05 447.7 Aortic ectasia Both 0 11 8 circulatory system red 11, 0 3 3 2 3 PRS_PLINK_1e.05 448 Disease of capillaries Both 1 13 8 circulatory system red 13, 1 4, 1 3, 0 3, 0 3, 0 0.2 1.26 0.874 0.058 1.22 0.132 29.4 0.0924 899 1 0 1.1 0.738 3.57 1.14 3050 1 0 3.14 0.427 3.59 -0.0116 3330000 1 0 0.988 0.0738 3.13 PRS_PLINK_1e.05 450 Noninfectious disorders of lymphatic channels Both 1 22 8 circulatory system red 22, 1 6, 0 5, 0 5, 1 6, 0 0.18 0.809 0.823 0.084 1.2 0.238 7.46 1.37 2.52 0.586 0.232 3.94 0.122 308 PRS_PLINK_1e.05 451 Phlebitis and thrombophlebitis Both 3 6 8 circulatory system red 6, 3 2, 0 1, 0 1, 0 2, 3 -0.056 2110 1 0 0.946 3.46 4.64 -0.0675 1060 1 0 0.935 0.487 1.29 PRS_PLINK_1e.05 451.2 Phlebitis and thrombophlebitis of lower extremities Both 2 2 8 circulatory system red 2, 2 1, 0 1, 2 1, 0 1, 2 -0.042 3170 1 0 0.959 0.0171 19900 -0.0994 1330 1 0 0.905 0.588 1.28 PRS_PLINK_1e.05 452 Other venous embolism and thrombosis Both 5 30 8 circulatory system red 30, 5 7, 3 7, 0 7, 0 8, 2 -0.759 0.541 0.16 0.795 0.468 0.112 1.18 -1.89 2.36 0.422 0.375 0.151 0.000418 11.7 -1.1 1.68 0.514 0.289 0.334 0.00226 6.48 -2.44 1.77 0.168 0.774 0.0871 1.88e-10 1.42 PRS_PLINK_1e.05 452.1 Iatrogenic pulmonary embolism and infarction Both 0 6 8 circulatory system red 6, 0 2 1 1 2 PRS_PLINK_1e.05 452.2 Deep vein thrombosis [DVT] Both 4 23 8 circulatory system red 23, 4 6, 2 6, 0 5, 0 6, 2 -0.445 0.684 0.516 0.288 0.641 0.00149 2.08 -1.89 2.47 0.444 0.352 0.151 0.0112 6.54 0.393 2.91 0.892 0.049 1.48 0.00905 138 -0.979 1.57 0.532 0.274 0.376 0.012 5.63 PRS_PLINK_1e.05 452.8 Postphlebitic syndrome Both 0 1 8 circulatory system red 1, 0 PRS_PLINK_1e.05 453 Chronic venous hypertension Both 0 3 8 circulatory system red 3, 0 1 1 1 1 PRS_PLINK_1e.05 454 Varicose veins Both 5 23 8 circulatory system red 23, 5 6, 1 6, 1 5, 2 6, 1 -0.149 0.925 0.872 0.06 0.861 0.0284 11.8 1.13 3.44 0.742 0.13 3.1 0.00347 4350 0.66 1.88 0.725 0.139 1.93 0.0465 241 0.577 2.8 0.837 0.077 1.78 0.0235 977 PRS_PLINK_1e.05 454.1 Varicose veins of lower extremity Both 4 19 8 circulatory system red 19, 4 5, 1 5, 1 4, 2 5, 0 0.212 0.961 0.825 0.084 1.24 0.044 71.4 1.15 6.71 0.864 0.064 3.17 0.000141 1770000 0.482 2.1 0.818 0.087 1.62 0.0785 75.8 -0.244 3.97 0.951 0.022 0.784 0.00184 391 PRS_PLINK_1e.05 454.11 Varicose veins of lower extremity, symptomtic Both 4 15 8 circulatory system red 15, 4 4, 1 4, 2 3, 1 4, 0 0.266 1.24 0.829 0.081 1.31 0.0629 26.4 -14.7 64.9 0.821 0.086 4.15e-07 1.67e-07 1.03e-06 0.308 2.2 0.888 0.051 1.36 0.0473 64.1 -0.0276 7.86 0.997 0.001 0.973 0.00219 491 PRS_PLINK_1e.05 455 Hemorrhoids Both 16 28 8 circulatory system red 28, 16 7, 6 7, 3 7, 6 7, 1 -0.0578 0.522 0.912 0.04 0.944 0.317 2.52 -0.0153 1.25 0.99 0.004 0.985 0.107 27.7 -0.195 1.23 0.874 0.059 0.823 0.00606 11.1 0.587 1.96 0.764 0.117 1.8 0.0512 114 PRS_PLINK_1e.05 456 Chronic venous insufficiency [CVI] Both 8 24 8 circulatory system red 24, 8 6, 2 6, 2 6, 4 6, 0 -0.454 0.87 0.602 0.22 0.635 0.0409 4.29 1.05 2.23 0.637 0.196 2.86 0.0115 1420 0.817 1.77 0.644 0.191 2.26 0.0525 101 0.432 3.24 0.894 0.049 1.54 0.000453 5110 PRS_PLINK_1e.05 457 Encounter for long-term (current) use of anticoagulants, antithrombotics, aspirin Both 1 12 8 circulatory system red 12, 1 3, 1 3, 0 3, 0 3, 0 -0.417 1.23 0.735 0.134 0.659 0.00961 4.98 0.0499 15700000 1 0 1.05 0.000302 266 -0.157 290 1 0 0.854 0.424 1.14 0.168 1520 1 0 1.18 0.466 14.9 PRS_PLINK_1e.05 457.2 Encounter for long-term (current) use of antiplatelets/antithrombotics Both 0 2 8 circulatory system red 2, 0 1 1 1 1 PRS_PLINK_1e.05 457.3 Encounter for long-term (current) use of aspirin Both 1 11 8 circulatory system red 11, 1 3, 1 3, 0 2, 0 3, 0 -0.273 1.54 0.859 0.066 0.761 0.0011 79.9 0.255 4370 1 0 1.29 0.585 1.39 -0.0761 1330 1 0 0.927 0.642 1.19 0.241 12400 1 0 1.27 0.43 9 PRS_PLINK_1e.05 458 Hypotension Both 3 38 8 circulatory system red 38, 3 10, 0 9, 0 9, 2 10, 1 0.0116 0.617 0.985 0.007 1.01 0.278 4.92 0.432 1.52 0.777 0.11 1.54 0.0366 158 0.00545 1.42 0.997 0.001 1.01 0.0518 26.3 PRS_PLINK_1e.05 458.1 Orthostatic hypotension Both 0 19 8 circulatory system red 19, 0 5 5 4 5 PRS_PLINK_1e.05 458.2 Iatrogenic hypotension Both 0 12 8 circulatory system red 12, 0 3 3 3 3 PRS_PLINK_1e.05 458.9 Hypotension NOS Both 3 35 8 circulatory system red 35, 3 9, 0 9, 0 8, 2 9, 1 0.122 0.631 0.847 0.072 1.13 0.316 5.74 0.428 1.6 0.79 0.103 1.53 0.0373 199 -0.0778 1.45 0.957 0.019 0.925 0.0432 22.7 PRS_PLINK_1e.05 459 Other disorders of circulatory system Both 9 49 8 circulatory system red 49, 9 12, 5 12, 0 12, 3 12, 1 -0.827 0.481 0.0858 1.067 0.437 0.126 1.08 -1.94 1.37 0.158 0.801 0.144 0.00158 1.59 -0.698 1.07 0.515 0.289 0.498 0.0251 3.64 -1.86 1.54 0.228 0.642 0.156 0.00168 2.25 PRS_PLINK_1e.05 459.1 Hemorrhage NOS Both 0 11 8 circulatory system red 11, 0 3 3 2 3 PRS_PLINK_1e.05 459.7 Blood vessel replaced Both 1 12 8 circulatory system red 12, 1 3, 0 3, 0 3, 0 3, 1 0.366 1.28 0.774 0.111 1.44 0.181 11.6 3.33 13100000 1 0 28.1 3.14e-14 1.57e+13 PRS_PLINK_1e.05 459.9 Circulatory disease NEC Both 9 46 8 circulatory system red 46, 9 12, 5 11, 0 11, 3 12, 1 -0.873 0.497 0.0787 1.104 0.417 0.13 1.04 -1.94 1.37 0.158 0.801 0.144 0.00158 1.59 -0.643 1.08 0.55 0.259 0.526 0.028 3.75 -1.92 1.55 0.215 0.668 0.147 0.00157 2.15 PRS_PLINK_1e.05 464 Acute sinusitis Both 11 34 9 respiratory coral4 34, 11 8, 2 8, 3 8, 3 9, 3 -0.117 0.481 0.807 0.093 0.889 0.344 2.4 -1.04 1.37 0.448 0.349 0.352 0.0109 3.24 -0.119 1.33 0.929 0.032 0.888 0.0231 10.1 -0.231 1.67 0.89 0.051 0.793 0.0571 1060 PRS_PLINK_1e.05 465 Acute upper respiratory infections of multiple or unspecified sites Both 24 36 9 respiratory coral4 36, 24 8, 8 9, 5 9, 4 9, 7 -0.0674 0.301 0.823 0.085 0.935 0.54 1.63 -0.957 1.1 0.386 0.413 0.384 0.0415 2.36 -0.219 0.964 0.82 0.086 0.803 0.153 4.58 -0.0128 1.08 0.991 0.004 0.987 0.144 7.27 PRS_PLINK_1e.05 465.2 Acute pharyngitis Both 17 37 9 respiratory coral4 37, 17 9, 5 9, 4 9, 3 9, 5 -0.128 0.335 0.702 0.154 0.88 0.475 1.63 -0.306 1.25 0.806 0.094 0.736 0.0739 6.48 -0.0862 1.04 0.934 0.03 0.917 0.15 5.6 -0.233 1.14 0.838 0.077 0.792 0.0954 6.37 PRS_PLINK_1e.05 465.4 Acute laryngitis and tracheitis Both 0 3 9 respiratory coral4 3, 0 1 1 1 1 PRS_PLINK_1e.05 470 Septal Deviations/Turbinate Hypertrophy Both 2 22 9 respiratory coral4 22, 2 5, 0 5, 1 5, 0 6, 1 0.949 0.851 0.265 0.577 2.58 0.52 921 -0.291 2.75 0.916 0.038 0.747 0.00673 369 -0.0623 1.84 0.973 0.012 0.94 0.0426 31.2 PRS_PLINK_1e.05 471 Nasal polyps Both 2 5 9 respiratory coral4 5, 2 1, 0 1, 0 1, 0 1, 2 0.283 13700000 1 0 1.33 0.38 3.77 3.3e-05 9080 1 0 1 0.205 4.99 PRS_PLINK_1e.05 472 Chronic pharyngitis and nasopharyngitis Both 5 23 9 respiratory coral4 23, 5 6, 1 6, 0 5, 2 6, 2 0.587 0.823 0.476 0.323 1.8 0.327 13.5 0.402 4.41 0.927 0.033 1.49 0.00136 288000 -1.62 2.57 0.528 0.277 0.197 0.000175 14.7 0.605 1.55 0.695 0.158 1.83 0.00151 948 PRS_PLINK_1e.05 473 Diseases of the larynx and vocal cords Both 5 26 9 respiratory coral4 26, 5 7, 3 6, 0 6, 0 7, 2 -0.0683 0.537 0.899 0.046 0.934 0.0556 2.76 0.321 1.81 0.859 0.066 1.38 0.029 3570 -0.319 1.55 0.837 0.077 0.727 0.0152 21.8 0.39 1.41 0.782 0.107 1.48 0.0479 848 PRS_PLINK_1e.05 473.1 Chronic laryngitis Both 0 1 9 respiratory coral4 1, 0 PRS_PLINK_1e.05 473.3 Paralysis/spasm of vocal cords or larynx Both 1 4 9 respiratory coral4 4, 1 1, 1 1, 0 1, 0 1, 0 -2.11 1.77e+08 1 0 0.121 5.41e-06 57400 0.0114 34.7 1 0 1.01 0.926 1.02 -0.0101 63.6 1 0 0.99 0.902 1.58 0.118 107 0.999 0 1.12 0.904 1.33 PRS_PLINK_1e.05 473.4 Voice disturbance Both 3 19 9 respiratory coral4 19, 3 5, 2 5, 0 4, 0 5, 1 -0.417 0.773 0.59 0.229 0.659 0.0359 2.97 0.0236 2.03 0.991 0.004 1.02 0.0355 64.4 -0.324 2.16 0.881 0.055 0.723 0.0381 197 -0.293 2.01 0.884 0.054 0.746 0.0102 29900 PRS_PLINK_1e.05 474 Acute and chronic tonsillitis Both 3 13 9 respiratory coral4 13, 3 3, 1 3, 1 3, 1 3, 0 0.538 0.876 0.539 0.268 1.71 0.412 18.3 0.0874 605 1 0 1.09 0.411 1.19 0.0433 126 1 0 1.04 0.703 2.35 -0.481 4910000 1 0 0.618 0.000132 2190 PRS_PLINK_1e.05 474.1 Acute tonsillitis Both 1 8 9 respiratory coral4 8, 1 1, 0 2, 0 2, 0 2, 1 0.103 10100000 1 0 1.11 0.272 10.6 -0.0119 628 1 0 0.988 0.000529 69000 PRS_PLINK_1e.05 474.2 Chronic tonsillitis and adenoiditis Both 3 8 9 respiratory coral4 8, 3 1, 1 2, 0 2, 1 2, 1 0.962 2.5 0.701 0.155 2.62 0.113 119 -0.00264 38.6 1 0 0.997 0.374 2.45 0.181 4010 1 0 1.2 0.566 1.29 -8.25 3.05e+08 1 0 0.00026 2.48e-22 8.43e+09 PRS_PLINK_1e.05 475 Chronic sinusitis Both 11 31 9 respiratory coral4 31, 11 7, 3 8, 2 7, 3 8, 3 -0.115 0.396 0.772 0.112 0.892 0.423 1.83 1.42 1.67 0.395 0.404 4.16 0.296 4420 -0.567 1.57 0.718 0.144 0.567 0.00278 9.23 0.606 1.53 0.693 0.159 1.83 0.0994 145 PRS_PLINK_1e.05 475.9 Postnasal drip Both 4 7 9 respiratory coral4 7, 4 2, 2 2, 1 1, 0 2, 1 2.41 18.1 0.894 0.049 11.2 9.5 13 0.353 1760 1 0 1.42 0.379 122 0.154 2340 1 0 1.17 0.337 1.82 -0.00795 152 1 0 0.992 0.338 3.47 PRS_PLINK_1e.05 476 Allergic rhinitis Both 24 32 9 respiratory coral4 32, 24 7, 5 8, 5 8, 11 8, 3 0.0826 0.328 0.801 0.096 1.09 0.599 2.04 0.609 1.24 0.625 0.204 1.84 0.199 35.9 0.54 0.92 0.557 0.254 1.72 0.346 10.3 0.101 1.2 0.933 0.03 1.11 0.127 9.23 PRS_PLINK_1e.05 477 Epistaxis or throat hemorrhage Both 1 11 9 respiratory coral4 11, 1 3, 0 3, 0 2, 0 3, 1 0.46 1.77 0.795 0.099 1.58 1.51 1.64 -0.0123 3200 1 0 0.988 0.676 1.96 PRS_PLINK_1e.05 478 Throat pain Both 1 5 9 respiratory coral4 5, 1 2, 0 1, 0 1, 1 1, 0 -0.158 116 0.999 0 0.854 0.109 30.8 0.346 2250 1 0 1.41 0.659 1.52 PRS_PLINK_1e.05 479 Other upper respiratory disease Both 11 32 9 respiratory coral4 32, 11 7, 2 8, 1 8, 6 8, 2 0.209 0.397 0.598 0.223 1.23 0.604 2.66 0.0217 2.17 0.992 0.003 1.02 2.44e-05 369 0.617 1.54 0.689 0.162 1.85 0.0675 56.6 -0.0524 1.3 0.968 0.014 0.949 0.0944 8.69 PRS_PLINK_1e.05 480 Pneumonia Both 13 43 9 respiratory coral4 43, 13 10, 2 11, 4 10, 4 11, 3 0.0507 0.386 0.895 0.048 1.05 0.501 2.33 1.14 1.35 0.395 0.403 3.14 0.288 1190 1.12 1.28 0.38 0.42 3.07 0.322 2540 0.116 2.03 0.954 0.02 1.12 0.00747 158000 PRS_PLINK_1e.05 480.1 Bacterial pneumonia Both 5 13 9 respiratory coral4 13, 5 4, 2 3, 1 3, 0 3, 2 0.576 1.03 0.575 0.241 1.78 0.405 2.06 0.514 3.44 0.881 0.055 1.67 0.00658 272 -1.73 35.9 0.961 0.017 0.177 2.72e-11 1.13e+09 1.22 3.78 0.747 0.126 3.37 2.67 3.86 PRS_PLINK_1e.05 480.11 Pneumococcal pneumonia Both 3 5 9 respiratory coral4 5, 3 2, 2 1, 1 1, 0 1, 0 -1.65 8e+05 1 0 0.192 0.0263 0.797 0.315 1100 1 0 1.37 0.665 1.83 -0.0402 663 1 0 0.961 0.934 1.1 0.376 4360 1 0 1.46 0.457 1.86 PRS_PLINK_1e.05 480.12 Pseudomonal pneumonia Both 1 2 9 respiratory coral4 2, 1 1, 0 1, 1 1, 0 1, 1 -0.0299 154 1 0 0.971 0.87 1.4 -0.0131 86.3 1 0 0.987 0.896 1.08 PRS_PLINK_1e.05 480.2 Viral pneumonia Both 1 7 9 respiratory coral4 7, 1 2, 1 2, 0 1, 0 2, 0 -0.0191 177 1 0 0.981 0.859 1.11 -0.000724 2320 1 0 0.999 0.195 4.82 0.156 6710 1 0 1.17 0.00342 670 -0.0645 560 1 0 0.938 0.472 1.35 PRS_PLINK_1e.05 480.3 Pneumonia due to fungus (mycoses) Both 2 3 9 respiratory coral4 3, 2 1, 0 1, 0 0, 1 1, 1 6.05e-05 6780 1 0 1 0.369 2.71 -0.00154 318 1 0 0.998 0.973 1.06 -0.0107 101 1 0 0.989 0.925 1.05 PRS_PLINK_1e.05 480.5 Bronchopneumonia and lung abscess Both 0 1 9 respiratory coral4 1, 0 PRS_PLINK_1e.05 481 Influenza Both 4 22 9 respiratory coral4 22, 4 5, 0 5, 2 5, 1 6, 1 0.442 0.781 0.571 0.243 1.56 0.285 10.3 -0.0787 2.13 0.971 0.013 0.924 0.0185 37.5 7.41e-13 10.9 1 0 1 4.72e-08 53200 1.75 2.79 0.53 0.276 5.75 0.0771 4430 PRS_PLINK_1e.05 483 Acute bronchitis and bronchiolitis Both 9 35 9 respiratory coral4 35, 9 9, 0 9, 2 8, 4 9, 3 0.565 0.481 0.24 0.619 1.76 0.756 5.13 1.4 1.52 0.356 0.448 4.07 0.276 5130 0.11 1.74 0.95 0.022 1.12 0.00355 52.7 1 1.32 0.449 0.347 2.72 0.32 791 PRS_PLINK_1e.05 495 Asthma Both 15 45 9 respiratory coral4 45, 15 11, 3 11, 3 11, 5 11, 4 0.132 0.363 0.716 0.145 1.14 0.573 2.35 0.0933 1.05 0.929 0.032 1.1 0.157 8.53 1.16 1.04 0.265 0.577 3.19 0.565 35.9 0.892 1.25 0.475 0.324 2.44 0.257 41.5 PRS_PLINK_1e.05 495.1 Chronic obstructive asthma Both 1 3 9 respiratory coral4 3, 1 1, 0 1, 0 0, 1 1, 0 0.0924 71400 1 0 1.1 0.204 4.11 -0.00528 62.1 1 0 0.995 0.918 1.16 PRS_PLINK_1e.05 495.11 Chronic obstructive asthma with exacerbation Both 1 3 9 respiratory coral4 3, 1 1, 0 1, 0 0, 1 1, 0 0.0733 20600 1 0 1.08 0.0581 736 -0.00528 62.1 1 0 0.995 0.918 1.16 PRS_PLINK_1e.05 495.2 Asthma with exacerbation Both 7 26 9 respiratory coral4 26, 7 7, 1 6, 1 6, 4 7, 1 0.0481 0.541 0.929 0.032 1.05 0.391 3.42 -0.515 1.91 0.787 0.104 0.597 0.00138 654 2.53 2.03 0.212 0.673 12.5 0.794 6730 -0.512 1.9 0.787 0.104 0.599 0.00284 107 PRS_PLINK_1e.05 496 Chronic airway obstruction Both 7 31 9 respiratory coral4 31, 7 8, 1 8, 1 7, 3 8, 2 0.0309 0.445 0.945 0.025 1.03 0.399 2.52 1.23 1.99 0.536 0.271 3.43 0.0087 2310 0.167 1.29 0.897 0.047 1.18 0.109 13.1 -1.18 2.19 0.59 0.229 0.308 9.49e-06 6760000 PRS_PLINK_1e.05 496.1 Emphysema Both 1 12 9 respiratory coral4 12, 1 3, 1 3, 0 3, 0 3, 0 -0.409 1.02 0.687 0.163 0.664 0.0245 5.3 -0.345 3020 1 0 0.708 0.0496 5.59 0.0581 4330 1 0 1.06 0.108 32.8 -0.37 7940000 1 0 0.691 0.000446 412 PRS_PLINK_1e.05 496.2 Chronic bronchitis Both 3 22 9 respiratory coral4 22, 3 6, 0 5, 0 5, 2 6, 1 0.292 0.598 0.625 0.204 1.34 0.386 5.35 -0.237 2.05 0.908 0.042 0.789 0.000127 81.1 0.17 1.52 0.911 0.04 1.18 0.0165 27 PRS_PLINK_1e.05 496.21 Obstructive chronic bronchitis Both 2 20 9 respiratory coral4 20, 2 5, 0 5, 0 5, 1 5, 1 0.196 0.643 0.761 0.119 1.22 0.294 6.11 0.766 2.3 0.739 0.132 2.15 0.00273 717 0.666 1.81 0.713 0.147 1.95 0.12 66.5 PRS_PLINK_1e.05 496.3 Bronchiectasis Both 4 2 9 respiratory coral4 2, 4 1, 1 0, 1 1, 2 1, 1 -1.89 1250 0.999 0.001 0.151 2.4e-05 336 -0.0119 104 1 0 0.988 0.831 1.17 -3.36 12900 1 0 0.0347 3.38e-09 3100 PRS_PLINK_1e.05 497 Bronchitis Both 5 28 9 respiratory coral4 28, 5 7, 0 7, 0 7, 1 7, 4 0.997 0.74 0.178 0.75 2.71 0.647 4210 -0.0435 3.58 0.99 0.004 0.957 0.000667 1090 1.55 1.66 0.35 0.456 4.73 0.275 35800000 PRS_PLINK_1e.05 498 Acute bronchospasm Both 2 7 9 respiratory coral4 7, 2 2, 0 2, 1 1, 1 2, 0 0.172 631 1 0 1.19 0.558 2.89 1.14 4160 1 0 3.13 0.0423 134 -0.00715 44.8 1 0 0.993 0.935 1.07 PRS_PLINK_1e.05 499 Cystic fibrosis Both 2 5 9 respiratory coral4 5, 2 2, 0 1, 0 1, 0 1, 2 0.575 2790000 1 0 1.78 0.00857 87.3 1.29 1760 0.999 0 3.63 1.21e-05 5470000 PRS_PLINK_1e.05 500 Lung disease due to external agents Both 1 2 9 respiratory coral4 2, 1 1, 0 1, 1 1, 0 1, 1 -0.0118 79.1 1 0 0.988 0.799 1.2 -0.00251 19 1 0 0.997 0.947 1.39 PRS_PLINK_1e.05 500.1 Extrinsic allergic alveolitis Both 1 1 9 respiratory coral4 1, 1 0.0469 271 1 0 1.05 0.549 1.68 PRS_PLINK_1e.05 501 Pneumonitis due to inhalation of food or vomitus Both 0 10 9 respiratory coral4 10, 0 3 2 2 3 PRS_PLINK_1e.05 502 Postinflammatory pulmonary fibrosis Both 2 7 9 respiratory coral4 7, 2 2, 1 2, 1 1, 0 2, 0 0.066 63.6 0.999 0 1.07 0.0226 38.8 2.8 297 0.992 0.003 16.5 4.6e-16 1.75e+17 -0.0188 2540 1 0 0.981 0.66 1.99 0.0425 1020 1 0 1.04 0.737 1.66 PRS_PLINK_1e.05 503 Pulmonary congestion and hypostasis Both 0 11 9 respiratory coral4 11, 0 3 3 2 3 PRS_PLINK_1e.05 504 Other alveolar and parietoalveolar pneumonopathy Both 2 3 9 respiratory coral4 3, 2 1, 0 1, 1 1, 1 1, 0 -8.15 4980 0.999 0.001 0.000289 3.25e-20 1.18e+11 -3.42e-05 15.1 1 0 1 0.935 1.06 0.0123 20.7 1 0 1.01 0.906 1.07 PRS_PLINK_1e.05 504.1 Idiopathic fibrosing alveolitis Both 2 1 9 respiratory coral4 1, 2 -0.00682 15.4 1 0 0.993 0.922 1.07 PRS_PLINK_1e.05 505 Other pulmonary inflamation or edema Both 4 19 9 respiratory coral4 19, 4 5, 1 5, 1 4, 0 5, 2 1.22 1.51 0.421 0.376 3.37 0.125 1430 0.432 2.31 0.852 0.07 1.54 0.0338 2360 0.156 447 1 0 1.17 0.235 1.64 -2.56 8.59 0.766 0.116 0.0776 8.64e-12 631000 PRS_PLINK_1e.05 506 Empyema and pneumothorax Both 2 23 9 respiratory coral4 23, 2 6, 1 6, 1 5, 0 6, 0 0.0513 0.667 0.939 0.027 1.05 0.0398 14.5 -0.281 1.76 0.873 0.059 0.755 0.000739 21.9 0.227 2.37 0.924 0.034 1.25 0.00171 453 0.414 1.78 0.816 0.088 1.51 0.0663 34.6 PRS_PLINK_1e.05 507 Pleurisy; pleural effusion Both 1 28 9 respiratory coral4 28, 1 7, 0 7, 0 7, 0 7, 1 0.193 0.592 0.745 0.128 1.21 0.293 7.84 0.187 1.41 0.894 0.048 1.21 0.0544 22.6 PRS_PLINK_1e.05 508 Pulmonary collapse; interstitial and compensatory emphysema Both 1 25 9 respiratory coral4 25, 1 7, 1 6, 0 6, 0 6, 0 -0.196 0.746 0.793 0.101 0.822 0.0444 8.07 -0.295 2.41 0.903 0.044 0.745 0.00392 37.5 -1.59 4.29 0.711 0.148 0.204 2.63e-05 1700 -0.219 2.54 0.931 0.031 0.803 0.00135 39.4 PRS_PLINK_1e.05 509 Respiratory failure, insufficiency, arrest Both 5 37 9 respiratory coral4 37, 5 10, 2 9, 2 9, 0 9, 1 -0.315 0.505 0.532 0.274 0.73 0.241 1.92 0.324 1.69 0.848 0.072 1.38 0.0534 55.9 -1.19 1.51 0.43 0.367 0.304 0.00195 4 -0.566 1.48 0.701 0.154 0.568 0.00681 178 PRS_PLINK_1e.05 509.1 Respiratory failure Both 1 24 9 respiratory coral4 24, 1 6, 0 6, 1 6, 0 6, 0 0.352 0.733 0.631 0.2 1.42 0.306 28.3 0.929 1.92 0.629 0.201 2.53 0.101 104 PRS_PLINK_1e.05 509.2 Respiratory insufficiency Both 0 14 9 respiratory coral4 14, 0 4 3 3 4 PRS_PLINK_1e.05 509.3 Pulmonary insufficiency or respiratory failure following trauma and surgery Both 1 13 9 respiratory coral4 13, 1 4, 0 3, 0 3, 0 3, 1 -1.14 2.55 0.656 0.183 0.321 0.000227 17.9 0.249 477 1 0 1.28 0.0349 478 PRS_PLINK_1e.05 509.8 Dependence on respirator [Ventilator] or supplemental oxygen Both 3 19 9 respiratory coral4 19, 3 5, 2 5, 1 4, 0 5, 0 -0.95 0.833 0.254 0.595 0.387 0.0376 1.57 0.401 2.26 0.859 0.066 1.49 7.55e-05 286000 -0.0574 291 1 0 0.944 0.754 1.17 -1.71 4.41 0.699 0.156 0.182 0.000136 198 PRS_PLINK_1e.05 510 Other diseases of lung Both 9 40 9 respiratory coral4 40, 9 10, 1 10, 2 10, 4 10, 2 0.392 0.412 0.342 0.466 1.48 0.691 3.49 0.976 1.51 0.517 0.286 2.65 0.101 41200 1.31 1.53 0.392 0.406 3.7 0.269 391000 0.0954 1.84 0.959 0.018 1.1 0.000819 2150 PRS_PLINK_1e.05 510.2 Lung transplant Both 0 2 9 respiratory coral4 2, 0 1 1 1 1 PRS_PLINK_1e.05 512 Other symptoms of respiratory system Both 31 33 9 respiratory coral4 33, 31 8, 7 8, 9 8, 13 8, 2 -0.285 0.306 0.352 0.454 0.752 0.417 1.32 -0.292 0.867 0.736 0.133 0.747 0.152 3.3 0.557 0.913 0.542 0.266 1.75 0.329 9.55 -1.53 1.35 0.257 0.589 0.217 0.00199 2.01 PRS_PLINK_1e.05 512.1 Wheezing Both 5 16 9 respiratory coral4 16, 5 4, 0 4, 1 4, 3 4, 1 0.339 0.871 0.697 0.157 1.4 0.273 14.2 0.261 1790 1 0 1.3 0.718 1.34 -2.02 15.4 0.895 0.048 0.133 0.115 0.155 0.0229 40.2 1 0 1.02 0.762 1.61e+08 PRS_PLINK_1e.05 512.2 Painful respiration Both 5 25 9 respiratory coral4 25, 5 7, 2 6, 1 6, 2 6, 0 -0.309 0.499 0.535 0.271 0.734 0.248 1.81 -2.32 2.15 0.281 0.552 0.0981 0.000206 3.19 0.413 1.46 0.778 0.109 1.51 0.0129 17.7 -0.946 1.69 0.576 0.24 0.388 0.000151 5.69 PRS_PLINK_1e.05 512.3 Abnormal chest sounds Both 0 3 9 respiratory coral4 3, 0 1 1 1 1 PRS_PLINK_1e.05 512.7 Shortness of breath Both 14 33 9 respiratory coral4 33, 14 8, 3 8, 2 8, 7 8, 2 -0.00454 0.374 0.99 0.004 0.995 0.493 2.06 -1.95 1.83 0.289 0.54 0.143 2.51e-05 3.38 1.09 1.37 0.425 0.371 2.97 0.223 115 -0.395 1.46 0.787 0.104 0.674 0.0109 16.5 PRS_PLINK_1e.05 512.8 Cough Both 22 33 9 respiratory coral4 33, 22 8, 5 8, 6 8, 9 8, 2 -0.159 0.337 0.636 0.197 0.853 0.451 1.6 -0.0271 1.02 0.979 0.009 0.973 0.159 6.03 1.32 1.22 0.279 0.554 3.74 0.462 55.3 -0.547 1.5 0.715 0.146 0.579 0.00674 13.7 PRS_PLINK_1e.05 512.9 Other dyspnea Both 18 33 9 respiratory coral4 33, 18 8, 4 8, 3 8, 9 8, 2 -0.197 0.343 0.566 0.248 0.821 0.425 1.56 -1.13 1.27 0.375 0.426 0.323 0.00321 2.67 0.848 1.21 0.483 0.316 2.33 0.217 23 -0.952 1.4 0.496 0.305 0.386 0.00551 3.84 PRS_PLINK_1e.05 513 Respiratory abnormalities Both 21 43 9 respiratory coral4 43, 21 10, 4 11, 5 10, 8 11, 4 -0.0207 0.326 0.949 0.023 0.979 0.521 1.83 -0.442 1.01 0.662 0.179 0.643 0.1 4.03 -0.227 1.05 0.829 0.082 0.797 0.0831 5.8 -0.676 1.21 0.576 0.239 0.509 0.0415 4.2 PRS_PLINK_1e.05 513.3 Hypoventilation Both 1 10 9 respiratory coral4 10, 1 3, 1 2, 0 2, 0 3, 0 0.609 1.45 0.674 0.171 1.84 0.0248 15.3 -0.255 12200000 1 0 0.775 4.34e-05 9980 0.637 2130 1 0 1.89 0.183 25.8 0.0758 361 1 0 1.08 0.757 1.69 PRS_PLINK_1e.05 513.31 Apnea Both 1 5 9 respiratory coral4 5, 1 2, 0 1, 1 1, 0 1, 0 -0.183 889000 1 0 0.833 0.0703 2.3 -0.0511 7370 1 0 0.95 0.268 2.49 PRS_PLINK_1e.05 513.32 Orthopnea Both 0 2 9 respiratory coral4 2, 0 1 1 1 1 PRS_PLINK_1e.05 513.4 Hyperventilation Both 1 2 9 respiratory coral4 2, 1 1, 0 1, 1 1, 0 1, 1 0.0265 60 1 0 1.03 0.959 1.05 0.0136 141 1 0 1.01 0.288 1.12 PRS_PLINK_1e.05 513.8 Disorders of diaphragm Both 0 3 9 respiratory coral4 3, 0 1 1 1 1 PRS_PLINK_1e.05 514 Abnormal findings examination of lungs Both 6 41 9 respiratory coral4 41, 6 11, 1 10, 1 10, 1 10, 3 0.216 0.498 0.664 0.178 1.24 0.408 3.62 0.532 1.74 0.76 0.119 1.7 0.0362 3720 0.426 1.36 0.755 0.122 1.53 0.0636 559 -0.121 1.72 0.944 0.025 0.886 0.000247 3230 PRS_PLINK_1e.05 514.1 Abnormal results of function study of pulmonary system Both 0 2 9 respiratory coral4 2, 0 1 1 1 1 PRS_PLINK_1e.05 514.2 Solitary pulmonary nodule Both 3 25 9 respiratory coral4 25, 3 7, 0 6, 0 6, 1 6, 2 0.248 0.7 0.724 0.141 1.28 0.104 13.5 0.491 1.51 0.745 0.128 1.63 0.0994 39.4 0.262 1.64 0.873 0.059 1.3 0.0354 55.4 PRS_PLINK_1e.05 516 Abnormal sputum Both 3 10 9 respiratory coral4 10, 3 3, 0 2, 0 2, 0 3, 3 0.662 1.39 0.634 0.198 1.94 0.0257 104 0.0839 18.3 0.996 0.002 1.09 1.07 47.8 PRS_PLINK_1e.05 516.1 Hemoptysis Both 3 11 9 respiratory coral4 11, 3 3, 0 3, 0 2, 0 3, 3 0.529 1.4 0.706 0.151 1.7 0.0464 498 0.0839 18.3 0.996 0.002 1.09 1.07 47.8 PRS_PLINK_1e.05 519 Other diseases of respiratory system, not elsewhere classified Both 8 54 9 respiratory coral4 54, 8 13, 0 13, 3 13, 2 14, 3 0.568 0.493 0.249 0.603 1.76 0.67 5.85 1.24 1.46 0.399 0.399 3.44 0.233 22500000 0.928 1.27 0.466 0.332 2.53 0.216 223 0.809 1.6 0.613 0.212 2.25 0.0948 4590 PRS_PLINK_1e.05 519.1 Tracheostomy complications Both 0 1 9 respiratory coral4 1, 0 PRS_PLINK_1e.05 519.2 Respiratory complications Both 0 4 9 respiratory coral4 4, 0 1 1 1 1 PRS_PLINK_1e.05 519.8 Other diseases of respiratory system, NEC Both 4 23 9 respiratory coral4 23, 4 6, 0 6, 0 5, 2 6, 2 0.0554 0.783 0.944 0.025 1.06 0.0405 73.3 2.03 3.82 0.595 0.225 7.62 0.00435 47900 -0.187 2.14 0.93 0.031 0.83 0.00241 111 PRS_PLINK_1e.05 519.9 Symptoms involving respiratory system and other chest symptoms Both 6 43 9 respiratory coral4 43, 6 10, 0 11, 2 10, 2 11, 2 0.493 0.49 0.314 0.503 1.64 0.648 9.52 -0.207 1.49 0.889 0.051 0.813 0.00882 35.8 0.81 1.4 0.563 0.249 2.25 0.132 1150 0.674 1.55 0.663 0.178 1.96 0.00127 1620 PRS_PLINK_1e.05 520 Disorders of tooth development Both 0 8 10 digestive chartreuse4 8, 0 1 2 2 2 PRS_PLINK_1e.05 520.1 Hereditary disturbances in tooth structure Both 0 5 10 digestive chartreuse4 5, 0 2 1 1 1 PRS_PLINK_1e.05 520.2 Disturbances in tooth eruption Both 0 9 10 digestive chartreuse4 9, 0 2 2 2 2 PRS_PLINK_1e.05 521 Diseases of hard tissues of teeth Both 0 13 10 digestive chartreuse4 13, 0 4 3 3 3 PRS_PLINK_1e.05 521.1 Dental caries Both 0 12 10 digestive chartreuse4 12, 0 3 3 3 3 PRS_PLINK_1e.05 522 Diseases of pulp and periapical tissues Both 1 7 10 digestive chartreuse4 7, 1 2, 0 2, 0 1, 1 2, 0 -0.915 5130 1 0 0.401 1.25e-09 6850 0.449 7190 1 0 1.57 0.238 81.9 PRS_PLINK_1e.05 522.5 Periapical abscess Both 1 5 10 digestive chartreuse4 5, 1 2, 0 1, 1 1, 0 1, 0 -0.0805 1730 1 0 0.923 0.539 1.3 0.0714 379 1 0 1.07 0.82 1.89 PRS_PLINK_1e.05 523 Gingival and periodontal diseases Both 0 10 10 digestive chartreuse4 10, 0 3 2 2 3 PRS_PLINK_1e.05 523.1 Gingivitis Both 0 3 10 digestive chartreuse4 3, 0 1 1 1 1 PRS_PLINK_1e.05 523.3 Periodontitis (acute or chronic) Both 0 4 10 digestive chartreuse4 4, 0 1 1 1 1 PRS_PLINK_1e.05 523.31 Acute periodontitis Both 0 2 10 digestive chartreuse4 2, 0 1 1 1 1 PRS_PLINK_1e.05 523.32 Chronic periodontitis Both 0 1 10 digestive chartreuse4 1, 0 PRS_PLINK_1e.05 524 Dentofacial anomalies, including malocclusion Both 2 6 10 digestive chartreuse4 6, 2 1, 0 1, 0 1, 0 2, 2 0.0889 84.7 0.999 0 1.09 0.945 1.11 0.536 6170 1 0 1.71 0.14 2.18 PRS_PLINK_1e.05 524.3 Anomalies of tooth position/malocclusion Both 0 2 10 digestive chartreuse4 2, 0 1 1 1 1 PRS_PLINK_1e.05 525 Other diseases of the teeth and supporting structures Both 1 17 10 digestive chartreuse4 17, 1 5, 0 4, 1 4, 0 4, 0 -0.331 0.948 0.727 0.138 0.719 0.105 6.02 -0.0234 418 1 0 0.977 0.883 2.68 PRS_PLINK_1e.05 525.1 Loss of teeth or edentulism Both 0 7 10 digestive chartreuse4 7, 0 2 2 1 2 PRS_PLINK_1e.05 526 Diseases of the jaws Both 4 37 10 digestive chartreuse4 37, 4 9, 0 9, 2 9, 0 9, 2 0.309 0.675 0.647 0.189 1.36 0.305 37.7 0.301 2.05 0.883 0.054 1.35 0.000122 849 0.336 2.48 0.892 0.049 1.4 0.0081 368 PRS_PLINK_1e.05 526.1 Cysts of the jaws Both 1 6 10 digestive chartreuse4 6, 1 2, 0 1, 0 1, 1 2, 0 -0.015 79.6 1 0 0.985 0.674 1.04 -0.131 18900 1 0 0.877 0.00923 72.5 PRS_PLINK_1e.05 526.3 Anomalies of jaw size/symmetry Both 1 2 10 digestive chartreuse4 2, 1 1, 1 1, 0 1, 1 1, 0 0.0187 89.3 1 0 1.02 0.942 1.16 -0.00372 30.9 1 0 0.996 0.942 1.03 PRS_PLINK_1e.05 526.4 Temporomandibular joint disorders Both 2 20 10 digestive chartreuse4 20, 2 5, 0 5, 1 5, 0 5, 1 0.377 0.872 0.665 0.177 1.46 0.237 12.4 0.509 2.18 0.815 0.089 1.66 0.0206 61.8 -2.02 5.83 0.729 0.137 0.133 2.15e-05 1310000 PRS_PLINK_1e.05 526.41 Temporomandibular joint disorder, unspecified Both 2 17 10 digestive chartreuse4 17, 2 5, 1 4, 0 4, 0 4, 1 0.427 1.18 0.717 0.144 1.53 0.187 48.8 0.944 2.47 0.702 0.154 2.57 0.00908 177 -0.0509 3860 1 0 0.95 0.304 0.753 2.64 3.83 0.49 0.309 14 0.0735 942000 PRS_PLINK_1e.05 526.42 Arthralgia/ankylosis of temporomandibular joint Both 1 9 10 digestive chartreuse4 9, 1 3, 0 2, 0 2, 0 2, 1 2.53e-13 5.19 1 0 1 0.000397 14400 2.09 5150 1 0 8.09 0.0304 1770 PRS_PLINK_1e.05 526.5 Inflammatory conditions of jaw Both 0 3 10 digestive chartreuse4 3, 0 1 1 1 1 PRS_PLINK_1e.05 526.9 Jaw disease NOS Both 0 8 10 digestive chartreuse4 8, 0 2 2 2 2 PRS_PLINK_1e.05 527 Diseases of the salivary glands Both 3 18 10 digestive chartreuse4 18, 3 5, 1 4, 0 4, 1 5, 1 0.629 0.822 0.445 0.352 1.88 0.458 60.1 2.44 9.05 0.787 0.104 11.5 1.55e-05 8540000 0.837 2.51 0.739 0.132 2.31 0.00196 137 0.424 6.85 0.951 0.022 1.53 4.71e-05 87900 PRS_PLINK_1e.05 527.1 Hypertrophy of salivary gland Both 0 2 10 digestive chartreuse4 2, 0 1 1 1 1 PRS_PLINK_1e.05 527.2 Sialoadenitis Both 1 5 10 digestive chartreuse4 5, 1 2, 0 1, 0 1, 0 1, 1 0.0227 1170 1 0 1.02 0.804 1.62 0.124 1480 1 0 1.13 0.724 3.25 PRS_PLINK_1e.05 527.7 Disturbance of salivary secretion Both 2 7 10 digestive chartreuse4 7, 2 2, 1 2, 0 1, 1 2, 0 -0.374 98.7 0.997 0.001 0.688 0.161 2.18 2.24 2720 0.999 0 9.36 1.5e-06 319 -5.76 41800000 1 0 0.00315 1.08e-12 4860000 -0.00322 406 1 0 0.997 0.95 1.05 PRS_PLINK_1e.05 527.8 Other specified diseases of the salivary glands Both 0 2 10 digestive chartreuse4 2, 0 1 1 1 1 PRS_PLINK_1e.05 528 Diseases of the oral soft tissues, excluding lesions specific for gingiva and tongue Both 6 34 10 digestive chartreuse4 34, 6 9, 1 8, 3 8, 0 9, 2 0.754 0.708 0.287 0.542 2.13 0.564 19.1 0.917 1.53 0.549 0.261 2.5 0.112 112000 -2.09 2.45 0.393 0.406 0.123 0.000116 11.2 -0.095 1.73 0.956 0.019 0.909 0.0188 28.3 PRS_PLINK_1e.05 528.1 Stomatitis and mucositis Both 1 9 10 digestive chartreuse4 9, 1 3, 1 2, 0 2, 0 2, 0 0.0637 4860000 1 0 1.07 0.487 26.1 -0.0835 784 1 0 0.92 0.418 1.87 0.0783 1180 1 0 1.08 0.484 1.13 -0.326 3380 1 0 0.722 0.635 14.4 PRS_PLINK_1e.05 528.11 Stomatitis and mucositis (ulcerative) Both 0 2 10 digestive chartreuse4 2, 0 1 1 1 1 PRS_PLINK_1e.05 528.12 Oral aphthae Both 1 3 10 digestive chartreuse4 3, 1 1, 1 1, 0 1, 0 1, 1 -2.18 5960 1 0 0.114 0.000697 6.29 -0.0153 68.5 1 0 0.985 0.826 1.32 0.0221 59.7 1 0 1.02 0.884 1.27 PRS_PLINK_1e.05 528.3 Cellulitis and abscess of oral soft tissues Both 0 7 10 digestive chartreuse4 7, 0 2 2 1 2 PRS_PLINK_1e.05 528.4 Cysts of oral soft tissues Both 0 2 10 digestive chartreuse4 2, 0 1 1 1 1 PRS_PLINK_1e.05 528.5 Diseases of lips Both 1 5 10 digestive chartreuse4 5, 1 2, 0 1, 0 1, 0 1, 1 -0.0153 746 1 0 0.985 0.7 1.33 -2.22 36700 1 0 0.108 2.98e-10 1350000 PRS_PLINK_1e.05 528.6 Leukoplakia of oral mucosa Both 2 2 10 digestive chartreuse4 2, 2 1, 1 0, 1 1, 0 1, 1 0.0396 379 1 0 1.04 0.706 1.08 0.0196 60.8 1 0 1.02 0.617 1.18 0.00383 23.5 1 0 1 0.581 1.16 PRS_PLINK_1e.05 528.7 Sialolithiasis Both 0 1 10 digestive chartreuse4 1, 0 PRS_PLINK_1e.05 529 Diseases and other conditions of the tongue Both 1 5 10 digestive chartreuse4 5, 1 2, 0 1, 0 1, 0 1, 1 0.006 455 1 0 1.01 0.531 2.84 -0.0288 4360 1 0 0.972 0.735 1.2 PRS_PLINK_1e.05 529.1 Glossitis Both 0 2 10 digestive chartreuse4 2, 0 1 1 1 1 PRS_PLINK_1e.05 529.6 Glossodynia Both 0 2 10 digestive chartreuse4 2, 0 1 1 1 1 PRS_PLINK_1e.05 530 Diseases of esophagus Both 26 36 10 digestive chartreuse4 36, 26 9, 6 9, 4 9, 8 9, 7 -0.102 0.29 0.726 0.139 0.903 0.526 1.53 -0.689 1.12 0.537 0.27 0.502 0.0461 3.47 0.108 0.844 0.898 0.047 1.11 0.251 4.93 0.948 1.29 0.463 0.334 2.58 0.245 49.5 PRS_PLINK_1e.05 530.1 Esophagitis, GERD and related diseases Both 25 36 10 digestive chartreuse4 36, 25 9, 6 9, 4 9, 8 9, 6 -0.159 0.297 0.593 0.227 0.853 0.488 1.46 -0.689 1.12 0.537 0.27 0.502 0.0461 3.47 0.108 0.844 0.898 0.047 1.11 0.251 4.93 1.02 1.35 0.451 0.346 2.78 0.239 51.8 PRS_PLINK_1e.05 530.11 GERD Both 24 36 10 digestive chartreuse4 36, 24 9, 5 9, 4 9, 8 9, 6 -0.103 0.303 0.735 0.134 0.902 0.514 1.57 -0.432 1.14 0.703 0.153 0.649 0.0684 4.83 0.261 0.879 0.767 0.115 1.3 0.283 6.17 1.25 1.41 0.374 0.428 3.49 0.281 65.4 PRS_PLINK_1e.05 530.13 Barrett's esophagus Both 0 10 10 digestive chartreuse4 10, 0 3 2 2 3 PRS_PLINK_1e.05 530.14 Reflux esophagitis Both 6 21 10 digestive chartreuse4 21, 6 6, 3 5, 0 5, 0 5, 3 0.374 0.737 0.612 0.213 1.45 0.381 10.6 -1.18 1.95 0.545 0.264 0.307 0.000126 9.56 -0.994 1.98 0.616 0.21 0.37 0.00773 103 0.696 1.71 0.683 0.165 2.01 0.0815 88.3 PRS_PLINK_1e.05 530.15 Eosinophilic esophagitis Both 1 5 10 digestive chartreuse4 5, 1 2, 0 1, 0 1, 0 1, 1 -0.0644 580 1 0 0.938 0.6 1.32 0.0139 14300 1 0 1.01 3.63e-07 55700 PRS_PLINK_1e.05 530.2 Esophageal bleeding (varices/hemorrhage) Both 0 6 10 digestive chartreuse4 6, 0 2 1 1 2 PRS_PLINK_1e.05 530.3 Stricture and stenosis of esophagus Both 1 9 10 digestive chartreuse4 9, 1 3, 0 2, 0 2, 0 2, 1 1.27 2.18 0.559 0.253 3.58 0.172 125 -0.0301 45.9 0.999 0 0.97 0.834 1.34 PRS_PLINK_1e.05 530.5 Disorders of esophageal motility Both 1 6 10 digestive chartreuse4 6, 1 2, 0 1, 0 1, 0 2, 1 -0.138 372 1 0 0.871 0.691 1.37 0.332 2990 1 0 1.39 0.585 3.19 PRS_PLINK_1e.05 530.6 Diverticulum of esophagus, acquired Both 0 2 10 digestive chartreuse4 2, 0 1 1 1 1 PRS_PLINK_1e.05 530.7 Gastroesophageal laceration-hemorrhage syndrome Both 2 1 10 digestive chartreuse4 1, 2 -9.39e-05 42 1 0 1 0.945 1.02 PRS_PLINK_1e.05 530.9 Heartburn Both 2 21 10 digestive chartreuse4 21, 2 6, 1 5, 0 5, 0 5, 1 -0.225 0.855 0.792 0.101 0.799 0.0949 6.06 0.0143 122 1 0 1.01 0.643 2.3 -0.642 2.32 0.782 0.107 0.526 0.00229 20.8 -0.0332 1.58 0.983 0.007 0.967 0.018 57.1 PRS_PLINK_1e.05 531 Peptic ulcer (excl. esophageal) Both 3 17 10 digestive chartreuse4 17, 3 5, 1 4, 0 4, 1 4, 1 0.0984 0.855 0.908 0.042 1.1 0.236 5.7 -0.17 488 1 0 0.843 0.33 1.68 -0.998 7.98 0.9 0.046 0.369 2.04e-06 60800 2.66 2.92 0.363 0.44 14.2 0.305 51600 PRS_PLINK_1e.05 531.1 Hemorrhage from gastrointestinal ulcer Both 1 1 10 digestive chartreuse4 1, 1 0.0116 79.5 1 0 1.01 0.904 1.2 PRS_PLINK_1e.05 531.2 Gastric ulcer Both 3 10 10 digestive chartreuse4 10, 3 3, 1 2, 0 2, 1 3, 1 0.974 2.5 0.697 0.157 2.65 0.095 503 0.438 2080 1 0 1.55 0.588 8.57 0.0911 1160 1 0 1.1 0.736 1.25 0.767 274 0.998 0.001 2.15 19.7 23 PRS_PLINK_1e.05 531.3 Duodenal ulcer Both 0 2 10 digestive chartreuse4 2, 0 1 1 1 1 PRS_PLINK_1e.05 531.4 Peptic ulcer, site unspecified Both 1 7 10 digestive chartreuse4 7, 1 2, 1 2, 0 1, 0 2, 0 -0.936 2e+06 1 0 0.392 0.26 0.612 -0.271 2750 1 0 0.762 9.34e-12 1.6e+22 -1.12 3190 1 0 0.327 0.000271 28.9 -0.0247 820 1 0 0.976 0.783 2.19 PRS_PLINK_1e.05 531.5 Gastrojejunal ulcer Both 0 1 10 digestive chartreuse4 1, 0 PRS_PLINK_1e.05 532 Dysphagia Both 7 34 10 digestive chartreuse4 34, 7 9, 3 8, 0 8, 0 9, 4 0.105 0.43 0.807 0.093 1.11 0.502 2.57 -1.26 1.75 0.471 0.327 0.283 0.000253 6.43 -1.2 1.5 0.424 0.373 0.301 4.69e-05 4.42 0.435 1.04 0.677 0.17 1.55 0.265 11.3 PRS_PLINK_1e.05 535 Gastritis and duodenitis Both 10 31 10 digestive chartreuse4 31, 10 8, 1 8, 2 7, 1 8, 6 0.793 0.581 0.173 0.763 2.21 0.807 7.72 1.43 1.71 0.404 0.394 4.18 0.0559 6560 0.496 1.49 0.739 0.132 1.64 0.0261 388 4.07 2.73 0.135 0.869 58.8 0.984 3.6e+12 PRS_PLINK_1e.05 535.1 Acute gastritis Both 2 11 10 digestive chartreuse4 11, 2 3, 0 3, 0 2, 1 3, 1 -0.184 1.71 0.914 0.039 0.832 0.0527 25 0.128 1180 1 0 1.14 0.705 1.2 0.0276 466 1 0 1.03 0.864 1.43 PRS_PLINK_1e.05 535.2 Atrophic gastritis Both 3 1 10 digestive chartreuse4 1, 3 -0.921 3.12e+08 1 0 0.398 1.98e-05 1260 PRS_PLINK_1e.05 535.6 Duodenitis Both 1 3 10 digestive chartreuse4 3, 1 1, 0 1, 1 1, 0 1, 0 1.01 5100 1 0 2.74 0.36 4.25 0.00989 38.1 1 0 1.01 0.946 1.07 PRS_PLINK_1e.05 535.8 Other specified gastritis Both 2 7 10 digestive chartreuse4 7, 2 2, 1 2, 0 1, 0 2, 1 -0.595 2.05 0.771 0.113 0.552 0.0251 11.8 0.202 7850 1 0 1.22 0.606 3.39 0.262 8900 1 0 1.3 0.533 1.87 0.0552 20900000 1 0 1.06 0.469 2.62 PRS_PLINK_1e.05 535.9 Gastritis and duodenitis, NOS Both 2 15 10 digestive chartreuse4 15, 2 4, 0 4, 0 3, 2 4, 0 -0.393 1.73 0.82 0.086 0.675 0.00499 141 0.937 457 0.998 0.001 2.55 1.05 3.29 PRS_PLINK_1e.05 536 Disorders of function of stomach Both 15 30 10 digestive chartreuse4 30, 15 8, 2 7, 1 7, 6 8, 6 0.377 0.422 0.372 0.43 1.46 0.691 3.43 0.162 1.45 0.911 0.04 1.18 0.000606 22.9 0.101 1.28 0.937 0.028 1.11 0.0662 10.5 0.411 1.25 0.742 0.129 1.51 0.158 22 PRS_PLINK_1e.05 536.3 Gastroparesis Both 6 16 10 digestive chartreuse4 16, 6 4, 1 4, 0 4, 2 4, 3 1.03 0.859 0.231 0.636 2.8 0.729 30.1 -0.0166 173 1 0 0.984 0.65 1.4 -0.406 4.38 0.926 0.033 0.667 0.000156 469 0.0458 349 1 0 1.05 0.537 2.17 PRS_PLINK_1e.05 536.7 Complications of gastrostomy, colostomy and enterostomy Both 2 2 10 digestive chartreuse4 2, 2 1, 0 1, 2 1, 0 1, 2 -0.392 1760 1 0 0.675 0.665 5.13 -0.1 274 1 0 0.904 0.898 1.12 PRS_PLINK_1e.05 536.8 Dyspepsia and other specified disorders of function of stomach Both 9 25 10 digestive chartreuse4 25, 9 7, 1 6, 2 6, 3 6, 3 0.111 0.531 0.834 0.079 1.12 0.422 3.13 0.934 2.29 0.684 0.165 2.54 0.0333 232 0.442 1.53 0.773 0.112 1.56 0.104 64.3 0.559 1.67 0.738 0.132 1.75 0.0584 45 PRS_PLINK_1e.05 537 Other disorders of stomach and duodenum Both 12 33 10 digestive chartreuse4 33, 12 9, 2 8, 1 8, 4 8, 4 0.00632 0.39 0.987 0.006 1.01 0.503 2.07 0.768 1.67 0.646 0.19 2.16 0.025 485 2.13 1.95 0.275 0.561 8.38 0.0691 17000 1.56 1.54 0.31 0.508 4.77 0.473 107000 PRS_PLINK_1e.05 537.1 Lesions of stomach and duodenum Both 0 1 10 digestive chartreuse4 1, 0 PRS_PLINK_1e.05 539 Bariatric surgery Both 1 27 10 digestive chartreuse4 27, 1 7, 0 7, 1 6, 0 7, 0 -0.0856 0.85 0.92 0.036 0.918 0.109 11.8 0.523 2.12 0.806 0.094 1.69 0.00395 396 PRS_PLINK_1e.05 540 Appendiceal conditions Both 0 6 10 digestive chartreuse4 6, 0 2 1 1 2 PRS_PLINK_1e.05 540.1 Appendicitis Both 0 3 10 digestive chartreuse4 3, 0 1 1 1 1 PRS_PLINK_1e.05 540.11 Acute appendicitis Both 0 3 10 digestive chartreuse4 3, 0 1 1 1 1 PRS_PLINK_1e.05 550 Abdominal hernia Both 9 49 10 digestive chartreuse4 49, 9 12, 3 12, 2 12, 3 12, 1 -0.0575 0.383 0.881 0.055 0.944 0.44 2.09 0.25 1.27 0.843 0.074 1.28 0.0292 45.9 0.359 1.08 0.739 0.132 1.43 0.184 16.5 0.671 1.58 0.672 0.173 1.96 0.0718 18000 PRS_PLINK_1e.05 550.1 Inguinal hernia Both 3 20 10 digestive chartreuse4 20, 3 4, 0 5, 3 5, 0 5, 0 -0.0942 0.622 0.88 0.056 0.91 0.273 3.32 -3.26 6.25 0.601 0.221 0.0383 0.0298 297 PRS_PLINK_1e.05 550.2 Diaphragmatic hernia Both 5 28 10 digestive chartreuse4 28, 5 7, 2 7, 1 7, 0 7, 2 0.1 0.545 0.854 0.068 1.11 0.394 3.61 0.0644 2.28 0.977 0.01 1.07 0.00331 130 -0.117 1.59 0.942 0.026 0.89 0.0232 71.6 0.131 1.44 0.927 0.033 1.14 0.094 77.4 PRS_PLINK_1e.05 550.3 Femoral hernia Both 0 2 10 digestive chartreuse4 2, 0 1 1 1 1 PRS_PLINK_1e.05 550.4 Umbilical hernia Both 1 13 10 digestive chartreuse4 13, 1 4, 0 3, 0 3, 0 3, 1 0.161 1.08 0.881 0.055 1.17 0.218 21.5 -0.00604 129 1 0 0.994 0.431 1.09 PRS_PLINK_1e.05 550.5 Ventral hernia Both 3 22 10 digestive chartreuse4 22, 3 6, 1 5, 0 5, 1 6, 1 0.0275 0.699 0.969 0.014 1.03 0.234 8.42 -0.612 4.88 0.9 0.046 0.542 0.521 0.566 0.411 5.6 0.942 0.026 1.51 0.000416 5800 1.23 2.15 0.566 0.247 3.43 0.148 804 PRS_PLINK_1e.05 550.6 Incisional hernia Both 0 13 10 digestive chartreuse4 13, 0 4 3 3 3 PRS_PLINK_1e.05 555 Inflammatory bowel disease and other gastroenteritis and colitis Both 5 11 10 digestive chartreuse4 11, 5 3, 2 3, 1 2, 1 3, 1 -0.897 0.91 0.324 0.489 0.408 0.07 1.45 0.296 377 0.999 0 1.35 0.444 5.07 0.104 328 1 0 1.11 0.535 3.17 -0.8 134 0.995 0.002 0.449 0.0919 0.202 PRS_PLINK_1e.05 555.1 Regional enteritis Both 1 9 10 digestive chartreuse4 9, 1 3, 1 2, 0 2, 0 2, 0 0.0508 2.14 0.981 0.008 1.05 0.0388 21 0.0644 17 0.997 0.001 1.07 0.41 1.85 -0.0954 2820 1 0 0.909 0.13 3.47 0.109 21.5 0.996 0.002 1.11 0.407 1.72 PRS_PLINK_1e.05 555.2 Ulcerative colitis Both 4 6 10 digestive chartreuse4 6, 4 2, 1 1, 0 1, 2 2, 1 -0.408 19.5 0.983 0.007 0.665 0.532 1460 -0.0163 686 1 0 0.984 0.639 1.41 -3.92 1.5e+08 1 0 0.0198 5.59e-26 2.23e+08 0.0415 87.3 1 0 1.04 0.927 1.47 PRS_PLINK_1e.05 555.21 Ulcerative colitis (chronic) Both 4 5 10 digestive chartreuse4 5, 4 2, 1 1, 2 1, 1 1, 0 0.0604 153 1 0 1.06 0.889 1.34 7.33 88400000 1 0 1530 48.2 3.73e+15 -0.364 3310 1 0 0.695 0.122 2.73 1.04 4830 1 0 2.82 0.352 2.98 PRS_PLINK_1e.05 556 Ulceration of the lower GI tract Both 0 7 10 digestive chartreuse4 7, 0 2 2 1 2 PRS_PLINK_1e.05 556.1 Ulceration of intestine Both 0 5 10 digestive chartreuse4 5, 0 2 1 1 1 PRS_PLINK_1e.05 556.11 Angiodysplasia of intestine (without mention of hemorrhage) Both 0 2 10 digestive chartreuse4 2, 0 1 1 1 1 PRS_PLINK_1e.05 557 Intestinal malabsorption (non-celiac) Both 7 19 10 digestive chartreuse4 19, 7 5, 3 5, 1 4, 0 5, 2 -0.0541 0.561 0.923 0.035 0.947 0.349 2.57 -0.0117 1.87 0.995 0.002 0.988 0.0399 49.7 6 46.9 0.898 0.047 403 239 673 0.062 1.73 0.971 0.013 1.06 0.0605 19.2 PRS_PLINK_1e.05 557.1 Celiac disease Both 4 8 10 digestive chartreuse4 8, 4 2, 0 2, 1 2, 1 2, 1 0.373 1.35 0.782 0.107 1.45 0.164 1.59 -0.169 6430 1 0 0.845 0.0306 3.94 0.0899 1990 1 0 1.09 0.0276 58.1 0.176 3040 1 0 1.19 0.615 2.75 PRS_PLINK_1e.05 558 Noninfectious gastroenteritis Both 11 23 10 digestive chartreuse4 23, 11 6, 3 6, 2 5, 3 6, 3 0.028 0.474 0.953 0.021 1.03 0.44 2.43 0.852 2.37 0.719 0.143 2.34 0.00109 2740 -0.0506 1.87 0.978 0.009 0.951 0.0399 60 0.457 1.59 0.773 0.112 1.58 0.117 125 PRS_PLINK_1e.05 559 Ileostomy status Both 0 7 10 digestive chartreuse4 7, 0 2 2 1 2 PRS_PLINK_1e.05 560 Intestinal obstruction without mention of hernia Both 5 20 10 digestive chartreuse4 20, 5 5, 1 5, 1 5, 2 5, 1 0.167 0.624 0.789 0.103 1.18 0.362 4.04 4.51 4.59 0.326 0.487 90.9 0.2 562000 2.16 3.01 0.473 0.325 8.67 0.114 3060 2.67 3.4 0.433 0.364 14.4 0.0318 7140 PRS_PLINK_1e.05 560.1 Paralytic ileus Both 3 9 10 digestive chartreuse4 9, 3 3, 1 2, 1 2, 1 2, 0 -0.394 1.71 0.818 0.087 0.674 0.642 0.717 -0.0764 1440 1 0 0.926 0.166 3.66 -1.14 15200000 1 0 0.319 1.82e-08 16600 0.221 4920 1 0 1.25 0.65 1.26 PRS_PLINK_1e.05 560.2 Impaction of intestine Both 2 1 10 digestive chartreuse4 1, 2 0.00348 102 1 0 1 0.853 1.04 PRS_PLINK_1e.05 560.3 Peritoneal or intestinal adhesions Both 0 1 10 digestive chartreuse4 1, 0 PRS_PLINK_1e.05 560.4 Other intestinal obstruction Both 2 13 10 digestive chartreuse4 13, 2 4, 0 3, 1 3, 0 3, 1 0.547 1.47 0.711 0.148 1.73 0.0342 31 -0.119 760 1 0 0.888 0.00362 63 0.111 3380 1 0 1.12 0.03 23.9 PRS_PLINK_1e.05 561 Symptoms involving digestive system Both 7 21 10 digestive chartreuse4 21, 7 6, 2 5, 2 5, 1 5, 2 -0.0889 0.587 0.88 0.056 0.915 0.264 2.45 0.487 2.44 0.842 0.075 1.63 0.0318 414 1.31 2.8 0.64 0.194 3.71 0.0426 1240000 3.83 5.14 0.456 0.341 46 0.0234 1e+10 PRS_PLINK_1e.05 562 Diverticulosis and diverticulitis Both 6 21 10 digestive chartreuse4 21, 6 6, 1 5, 1 5, 3 5, 1 0.435 0.749 0.562 0.25 1.54 0.276 29.8 -0.821 1.88 0.662 0.179 0.44 0.0121 11.3 0.239 1.59 0.881 0.055 1.27 0.0969 4000 2.25 5.18 0.665 0.177 9.44 9e-06 3.5e+07 PRS_PLINK_1e.05 562.1 Diverticulosis Both 6 21 10 digestive chartreuse4 21, 6 6, 1 5, 1 5, 3 5, 1 0.435 0.749 0.562 0.25 1.54 0.276 29.8 -0.821 1.88 0.662 0.179 0.44 0.0121 11.3 0.239 1.59 0.881 0.055 1.27 0.0969 4000 2.25 5.18 0.665 0.177 9.44 9e-06 3.5e+07 PRS_PLINK_1e.05 562.2 Diverticulitis Both 1 14 10 digestive chartreuse4 14, 1 4, 1 3, 0 3, 0 4, 0 0.568 1.33 0.669 0.175 1.77 0.187 95.7 0.069 1110 1 0 1.07 0.794 1.26 -0.428 327 0.999 0 0.652 0.25 1.17 1.84 68 0.978 0.009 6.27 2.35e-11 2.04e+12 PRS_PLINK_1e.05 564 Functional digestive disorders Both 27 27 10 digestive chartreuse4 27, 27 7, 6 7, 6 6, 11 7, 4 0.0644 0.325 0.843 0.074 1.07 0.593 1.93 0.615 1.05 0.559 0.252 1.85 0.333 14.3 0.683 0.921 0.458 0.339 1.98 0.424 11 -0.208 1.15 0.857 0.067 0.812 0.111 5.65 PRS_PLINK_1e.05 564.1 Irritable Bowel Syndrome Both 5 23 10 digestive chartreuse4 23, 5 6, 0 6, 1 5, 1 6, 3 0.582 0.596 0.33 0.482 1.79 0.651 7.68 0.253 2.36 0.915 0.039 1.29 0.0381 157 1.2 3.13 0.702 0.154 3.32 0.00172 1840 1.05 1.73 0.543 0.265 2.87 0.218 137 PRS_PLINK_1e.05 564.9 Personal history of diseases of digestive system Both 5 20 10 digestive chartreuse4 20, 5 5, 2 5, 0 5, 1 5, 2 -0.171 0.586 0.771 0.113 0.843 0.194 2.19 -1.18 4.5 0.793 0.101 0.307 1.33e-05 1670 0.467 2.93 0.873 0.059 1.6 0.000841 566 -2.23 2.63 0.396 0.402 0.107 0.000599 5.57 PRS_PLINK_1e.05 565 Anal and rectal conditions Both 11 31 10 digestive chartreuse4 31, 11 8, 2 8, 0 7, 4 8, 5 0.458 0.423 0.279 0.554 1.58 0.766 3.75 -0.458 1.41 0.745 0.128 0.633 0.00532 10.7 0.278 1.33 0.834 0.079 1.32 0.0723 41.4 2.26 1.5 0.132 0.878 9.6 0.911 524 PRS_PLINK_1e.05 565.1 Anal and rectal polyp Both 3 9 10 digestive chartreuse4 9, 3 3, 0 2, 0 2, 1 2, 2 1.63 1.86 0.379 0.421 5.11 0.444 184 0.0418 583 1 0 1.04 0.766 1.99 0.15 1410 1 0 1.16 0.568 1.3 PRS_PLINK_1e.05 567 Peritonitis and retroperitoneal infections Both 1 7 10 digestive chartreuse4 7, 1 2, 0 2, 1 1, 0 2, 0 1.63 4030 1 0 5.12 33.8 121 -1.25 1420 0.999 0 0.287 1.55e-07 7.85e+08 PRS_PLINK_1e.05 568 Other disorders of peritoneum Both 1 12 10 digestive chartreuse4 12, 1 3, 0 3, 0 3, 0 3, 1 0.0693 1.37 0.96 0.018 1.07 0.0383 52.6 -0.0317 507 1 0 0.969 0.496 1.61 PRS_PLINK_1e.05 568.1 Peritoneal adhesions (postoperative) (postinfection) Both 1 9 10 digestive chartreuse4 9, 1 2, 0 2, 0 2, 0 2, 1 -0.487 1.98 0.806 0.094 0.615 0.577 0.667 -0.126 1430 1 0 0.882 0.476 1.29 PRS_PLINK_1e.05 569 Other disorders of intestine Both 18 39 10 digestive chartreuse4 39, 18 9, 2 10, 5 9, 4 10, 7 0.387 0.381 0.31 0.509 1.47 0.746 3.15 1.08 1.26 0.391 0.408 2.94 0.356 115 -0.147 1.24 0.906 0.043 0.863 0.0448 615 2.08 1.6 0.192 0.718 8.03 0.691 1310 PRS_PLINK_1e.05 569.1 Toxic gastroenteritis and colitis Both 0 3 10 digestive chartreuse4 3, 0 1 1 1 1 PRS_PLINK_1e.05 569.2 Gastrointestinal complications Both 2 17 10 digestive chartreuse4 17, 2 5, 0 4, 0 4, 1 4, 1 -0.288 1.07 0.789 0.103 0.75 0.034 33.7 0.0189 80 1 0 1.02 0.00528 112 -2.2 4.23 0.603 0.219 0.111 9.73e-05 27.1 PRS_PLINK_1e.05 571 Chronic liver disease and cirrhosis Both 9 33 10 digestive chartreuse4 33, 9 9, 2 8, 1 8, 3 8, 3 0.0392 0.441 0.929 0.032 1.04 0.455 2.44 -0.0236 1.38 0.986 0.006 0.977 0.081 12.1 0.634 1.24 0.609 0.215 1.89 0.21 48.7 -0.102 1.54 0.947 0.024 0.903 0.0155 33.1 PRS_PLINK_1e.05 571.5 Other chronic nonalcoholic liver disease Both 9 34 10 digestive chartreuse4 34, 9 9, 2 8, 2 8, 2 9, 3 0.00372 0.443 0.993 0.003 1 0.436 2.36 0.496 1.27 0.696 0.158 1.64 0.193 18.6 0.693 1.3 0.592 0.227 2 0.213 62.3 -0.164 1.53 0.915 0.039 0.848 0.0178 34.4 PRS_PLINK_1e.05 571.51 Cirrhosis of liver without mention of alcohol Both 0 14 10 digestive chartreuse4 14, 0 4 3 3 4 PRS_PLINK_1e.05 571.6 Primary biliary cirrhosis Both 0 2 10 digestive chartreuse4 2, 0 1 1 1 1 PRS_PLINK_1e.05 571.8 Liver abscess and sequelae of chronic liver disease Both 1 12 10 digestive chartreuse4 12, 1 3, 0 3, 0 3, 1 3, 0 0.0826 1.82 0.964 0.016 1.09 0.00616 34.5 -1.31 166 0.994 0.003 0.269 0.00137 67.8 PRS_PLINK_1e.05 571.81 Portal hypertension Both 1 8 10 digestive chartreuse4 8, 1 2, 0 2, 1 2, 0 2, 0 -2.95e-12 9.11 1 0 1 0.983 3.03 -0.288 4350 1 0 0.75 0.0704 2.31 PRS_PLINK_1e.05 572 Ascites (non malignant) Both 1 23 10 digestive chartreuse4 23, 1 6, 0 6, 1 5, 0 6, 0 0.337 0.747 0.652 0.186 1.4 0.357 27.1 1.45 2.24 0.519 0.285 4.25 0.186 630 PRS_PLINK_1e.05 573 Other disorders of liver Both 7 38 10 digestive chartreuse4 38, 7 10, 2 9, 1 9, 2 10, 2 -0.165 0.458 0.718 0.144 0.848 0.337 2.04 -0.186 1.21 0.878 0.056 0.83 0.0786 7.54 1.18 1.56 0.451 0.346 3.26 0.26 1890000 -0.492 1.51 0.744 0.128 0.612 0.0196 12.8 PRS_PLINK_1e.05 573.1 Chronic passive congestion of liver Both 0 2 10 digestive chartreuse4 2, 0 1 1 1 1 PRS_PLINK_1e.05 573.2 Liver replaced by transplant Both 0 6 10 digestive chartreuse4 6, 0 2 1 1 2 PRS_PLINK_1e.05 573.3 Hepatomegaly Both 1 5 10 digestive chartreuse4 5, 1 2, 1 1, 0 1, 0 1, 0 -0.165 525 1 0 0.848 0.481 1.22 0.00467 57.3 1 0 1 0.84 1.05 0.0102 49.3 1 0 1.01 0.894 1.11 0.653 3220 1 0 1.92 0.288 8.82 PRS_PLINK_1e.05 573.4 Acute and subacute necrosis of liver Both 0 3 10 digestive chartreuse4 3, 0 1 1 1 1 PRS_PLINK_1e.05 573.5 Jaundice (not of newborn) Both 2 13 10 digestive chartreuse4 13, 2 4, 0 3, 1 3, 0 3, 1 -0.273 1.05 0.794 0.1 0.761 0.128 8.35 -0.695 1800 1 0 0.499 0.00538 0.57 0.121 3170000 1 0 1.13 0.704 1.65 PRS_PLINK_1e.05 573.6 Nonspecific elevation of levels of transaminase or lactic acid dehydrogenase [LDH] Both 7 31 10 digestive chartreuse4 31, 7 8, 0 8, 3 7, 1 8, 3 0.451 0.509 0.375 0.425 1.57 0.625 4.62 1.54 1.52 0.312 0.506 4.65 0.402 115 0.452 1.65 0.785 0.105 1.57 0.0992 150 -0.366 1.98 0.853 0.069 0.693 9.67e-05 164 PRS_PLINK_1e.05 573.7 Abnormal results of function study of liver Both 7 30 10 digestive chartreuse4 30, 7 8, 2 7, 2 7, 1 8, 2 0.0391 0.524 0.941 0.027 1.04 0.391 2.8 -1.41 2.14 0.511 0.292 0.244 9.24e-08 11.7 -0.921 1.59 0.563 0.25 0.398 0.0049 4.57 -0.738 1.6 0.644 0.191 0.478 0.0246 9.12 PRS_PLINK_1e.05 573.9 Abnormal serum enzyme levels Both 13 39 10 digestive chartreuse4 39, 13 10, 1 10, 5 9, 3 10, 4 0.642 0.424 0.13 0.887 1.9 0.912 4.76 3.08 1.95 0.115 0.938 21.7 1.02 88000 1.32 1.51 0.379 0.421 3.76 0.3 1490 1.83 1.89 0.334 0.476 6.2 0.217 80500 PRS_PLINK_1e.05 574 Cholelithiasis and cholecystitis Both 1 45 10 digestive chartreuse4 45, 1 12, 1 11, 0 11, 0 11, 0 -0.814 0.66 0.217 0.663 0.443 0.0161 1.83 -1.06 1.78 0.549 0.261 0.345 2.77e-06 8.35 -0.535 1.39 0.701 0.154 0.586 8.82e-05 12.5 -1.21 1.62 0.454 0.343 0.297 0.000249 7.72 PRS_PLINK_1e.05 574.1 Cholelithiasis Both 1 43 10 digestive chartreuse4 43, 1 11, 1 11, 0 10, 0 11, 0 -0.739 0.651 0.256 0.591 0.477 0.0273 1.88 -0.971 1.71 0.57 0.244 0.379 9.16e-07 7.62 -0.471 1.38 0.733 0.135 0.624 8.47e-05 9.15 -1.16 1.66 0.485 0.315 0.314 0.000225 8.73 PRS_PLINK_1e.05 574.11 Cholelithiasis with acute cholecystitis Both 0 6 10 digestive chartreuse4 6, 0 2 1 1 2 PRS_PLINK_1e.05 574.12 Cholelithiasis with other cholecystitis Both 0 14 10 digestive chartreuse4 14, 0 4 3 3 4 PRS_PLINK_1e.05 574.2 Calculus of bile duct Both 0 11 10 digestive chartreuse4 11, 0 3 3 2 3 PRS_PLINK_1e.05 574.3 Cholecystitis without cholelithiasis Both 0 14 10 digestive chartreuse4 14, 0 4 3 3 4 PRS_PLINK_1e.05 575 Other biliary tract disease Both 0 33 10 digestive chartreuse4 33, 0 9 8 8 8 PRS_PLINK_1e.05 575.1 Cholangitis Both 0 1 10 digestive chartreuse4 1, 0 PRS_PLINK_1e.05 575.2 Obstruction of bile duct Both 0 5 10 digestive chartreuse4 5, 0 2 1 1 1 PRS_PLINK_1e.05 575.6 Cholesterolosis of gallbladder Both 0 5 10 digestive chartreuse4 5, 0 2 1 1 1 PRS_PLINK_1e.05 575.7 Other disorders of gallbladder Both 0 12 10 digestive chartreuse4 12, 0 3 3 3 3 PRS_PLINK_1e.05 575.8 Other disorders of biliary tract Both 0 12 10 digestive chartreuse4 12, 0 3 3 3 3 PRS_PLINK_1e.05 577 Diseases of pancreas Both 3 31 10 digestive chartreuse4 31, 3 8, 0 8, 0 7, 0 8, 3 1.28 1.06 0.227 0.644 3.6 0.152 470 1 2.34 0.668 0.175 2.73 0.00171 66800000 PRS_PLINK_1e.05 577.1 Acute pancreatitis Both 1 19 10 digestive chartreuse4 19, 1 4, 0 5, 0 4, 0 5, 1 0.775 0.953 0.416 0.381 2.17 0.415 24.9 0.0185 1810 1 0 1.02 0.625 2.63 PRS_PLINK_1e.05 577.2 Chronic pancreatitis Both 0 3 10 digestive chartreuse4 3, 0 1 1 1 1 PRS_PLINK_1e.05 577.3 Cyst and pseudocyst of pancreas Both 0 4 10 digestive chartreuse4 4, 0 1 1 1 1 PRS_PLINK_1e.05 578 Gastrointestinal hemorrhage Both 13 46 10 digestive chartreuse4 46, 13 11, 3 11, 3 11, 5 12, 2 -0.013 0.333 0.969 0.014 0.987 0.529 1.87 0.829 1.27 0.514 0.289 2.29 0.16 38.3 0.402 1.1 0.714 0.146 1.5 0.208 36.5 -0.286 1.17 0.807 0.093 0.751 0.0716 5.81 PRS_PLINK_1e.05 578.1 Hematemesis Both 4 5 10 digestive chartreuse4 5, 4 2, 0 1, 0 1, 1 1, 3 0.0241 54 1 0 1.02 0.825 1.31 0.00913 1630 1 0 1.01 0.689 2.86 -0.102 4410 1 0 0.903 0.492 5.89 PRS_PLINK_1e.05 578.2 Blood in stool Both 7 33 10 digestive chartreuse4 33, 7 9, 1 8, 1 8, 4 8, 1 0.0958 0.434 0.825 0.083 1.1 0.499 2.53 0.591 1.72 0.731 0.136 1.81 0.0203 6460 1.85 1.76 0.293 0.534 6.38 0.314 9550 -0.447 1.6 0.779 0.108 0.639 0.0044 18.3 PRS_PLINK_1e.05 578.8 Hemorrhage of rectum and anus Both 7 31 10 digestive chartreuse4 31, 7 8, 1 8, 1 7, 4 8, 1 0.0411 0.513 0.936 0.029 1.04 0.376 2.8 0.497 1.63 0.76 0.119 1.64 0.0861 3010 0.0527 1.48 0.972 0.013 1.05 0.00943 26.1 0.526 1.75 0.763 0.117 1.69 0.0454 1e+09 PRS_PLINK_1e.05 578.9 Hemorrhage of gastrointestinal tract Both 3 16 10 digestive chartreuse4 16, 3 4, 0 4, 0 4, 1 4, 2 0.567 0.85 0.505 0.297 1.76 0.277 11.5 -0.099 49 0.998 0.001 0.906 0.915 0.942 1.7 2.7 0.528 0.278 5.49 0.158 743 PRS_PLINK_1e.05 579 Other symptoms involving abdomen and pelvis Both 6 41 10 digestive chartreuse4 41, 6 10, 1 10, 0 10, 3 10, 2 0.33 0.433 0.446 0.351 1.39 0.619 3.72 0.0172 1.63 0.992 0.004 1.02 0.00116 52.7 0.577 1.16 0.62 0.208 1.78 0.174 21.1 0.77 1.46 0.599 0.223 2.16 0.0976 1340 PRS_PLINK_1e.05 579.2 Splenomegaly Both 1 9 10 digestive chartreuse4 9, 1 3, 0 2, 0 2, 1 2, 0 -0.226 26.2 0.993 0.003 0.798 0.00179 362 -0.194 1970 1 0 0.824 0.11 5.14 PRS_PLINK_1e.05 579.8 Nonspecific abnormal findings in stool contents Both 2 19 10 digestive chartreuse4 19, 2 5, 0 5, 0 4, 1 5, 1 0.104 1.02 0.919 0.037 1.11 0.0345 29.2 -1.28 15.8 0.936 0.029 0.278 0.00241 31.7 0.192 2.1 0.927 0.033 1.21 0.0292 36 PRS_PLINK_1e.05 580 Nephritis; nephrosis; renal sclerosis Both 15 11 11 genitourinary black 11, 15 3, 2 3, 2 2, 4 3, 7 1.28 0.911 0.159 0.799 3.61 0.874 56.4 2.82 3.99 0.48 0.318 16.7 0.132 19.9 -1.11 3.07 0.718 0.144 0.33 0.293 0.388 2.33 2.19 0.287 0.542 10.3 0.467 4370 PRS_PLINK_1e.05 580.1 Glomerulonephritis Both 2 4 11 genitourinary black 4, 2 1, 1 1, 0 1, 0 1, 1 -0.0751 1410 1 0 0.928 0.433 1.88 -0.0353 137 1 0 0.965 0.635 1.17 -0.0137 41.5 1 0 0.986 0.814 1.06 -0.174 3420 1 0 0.841 0.19 1.72 PRS_PLINK_1e.05 580.11 Proliferative glomerulonephritis Both 1 1 11 genitourinary black 1, 1 -0.000484 48.7 1 0 1 0.991 1.03 PRS_PLINK_1e.05 580.12 Non-proliferative glomerulonephritis Both 0 1 11 genitourinary black 1, 0 PRS_PLINK_1e.05 580.13 Acute glomerulonephritis, NOS Both 1 1 11 genitourinary black 1, 1 -0.00193 14.8 1 0 0.998 0.967 1.03 PRS_PLINK_1e.05 580.14 Chronic glomerulonephritis, NOS Both 0 2 11 genitourinary black 2, 0 1 1 1 1 PRS_PLINK_1e.05 580.2 Nephrotic syndrome without mention of glomerulonephritis Both 0 3 11 genitourinary black 3, 0 1 1 1 1 PRS_PLINK_1e.05 580.3 Nephritis and nephropathy without mention of glomerulonephritis Both 13 11 11 genitourinary black 11, 13 3, 2 3, 2 2, 3 3, 6 1.27 0.93 0.171 0.766 3.57 0.83 84.6 2.82 3.99 0.48 0.318 16.7 0.132 19.9 -0.67 21 0.975 0.011 0.512 0.0386 6.67 2.59 2.39 0.278 0.557 13.3 0.523 1940 PRS_PLINK_1e.05 580.31 Nephritis and nephropathy in diseases classified elsewhere Both 11 9 11 genitourinary black 9, 11 3, 2 2, 1 2, 3 2, 5 1.89 1.38 0.17 0.77 6.6 0.825 1730 -0.0471 1200 1 0 0.954 0.598 2.28 2.18 15.7 0.889 0.051 8.89 53.5 54.1 0.522 2.04 0.798 0.098 1.69 1.35 1.76 PRS_PLINK_1e.05 580.32 Nephritis and nephropathy with pathological lesion Both 3 7 11 genitourinary black 7, 3 2, 1 2, 0 1, 0 2, 2 -1.36 10 0.892 0.05 0.256 0.217 0.309 0.0731 1450 1 0 1.08 0.000123 41600 -0.0571 434 1 0 0.944 0.628 1.13 0.183 1570000 1 0 1.2 0.204 6.64 PRS_PLINK_1e.05 580.4 Renal sclerosis, NOS Both 1 3 11 genitourinary black 3, 1 1, 0 1, 0 1, 1 1, 0 -0.0793 3380 1 0 0.924 0.349 2.37 -0.294 5120 1 0 0.745 0.549 1.87 PRS_PLINK_1e.05 585 Renal failure Both 24 16 11 genitourinary black 16, 24 4, 6 4, 3 4, 8 4, 7 0.568 0.588 0.334 0.476 1.76 0.652 6.47 0.674 2.29 0.768 0.114 1.96 0.00423 2.4e+07 2.77 2.47 0.262 0.582 16 0.35 437000 2.03 2.19 0.355 0.45 7.59 0.28 3080000 PRS_PLINK_1e.05 585.1 Acute renal failure Both 8 14 11 genitourinary black 14, 8 4, 1 3, 2 3, 1 4, 4 0.728 0.949 0.443 0.354 2.07 0.445 13.6 -1.86 4.03 0.645 0.191 0.156 0.133 56.6 0.653 10.4 0.95 0.022 1.92 1.87 2 2.27 4.03 0.573 0.242 9.72 0.0263 11.1 PRS_PLINK_1e.05 585.2 Renal failure NOS Both 4 6 11 genitourinary black 6, 4 2, 1 1, 0 1, 1 2, 2 -0.747 29.4 0.98 0.009 0.474 0.451 0.498 0.98 11000 1 0 2.66 0.339 8.61 8.08 12500 0.999 0 3240 5.61e-14 5.52e+17 -0.0393 1070 1 0 0.961 0.626 1.4 PRS_PLINK_1e.05 585.3 Chronic renal failure [CKD] Both 17 15 11 genitourinary black 15, 17 4, 5 4, 1 3, 7 4, 4 0.648 0.779 0.406 0.392 1.91 0.477 21.5 0.145 2.31 0.95 0.022 1.16 0.00475 321 1.93 2.34 0.411 0.386 6.86 0.192 2650 0.661 1.97 0.737 0.133 1.94 0.0384 2860 PRS_PLINK_1e.05 585.31 Renal dialysis Both 0 5 11 genitourinary black 5, 0 2 1 1 1 PRS_PLINK_1e.05 585.32 End stage renal disease Both 1 9 11 genitourinary black 9, 1 3, 0 2, 0 2, 0 2, 1 -0.391 1.77 0.825 0.084 0.676 0.0455 104 -0.0184 113 1 0 0.982 0.615 1.19 PRS_PLINK_1e.05 585.33 Chronic Kidney Disease, Stage III Both 7 11 11 genitourinary black 11, 7 3, 3 3, 1 2, 1 3, 2 0.309 0.901 0.731 0.136 1.36 0.31 18.6 -2.28 7.5 0.761 0.118 0.103 2.35e-06 37300 -0.688 1030 0.999 0 0.503 0.0154 0.672 -1.12 3.55 0.752 0.124 0.327 4.01e-06 43.1 PRS_PLINK_1e.05 585.34 Chronic Kidney Disease, Stage IV Both 0 10 11 genitourinary black 10, 0 3 2 2 3 PRS_PLINK_1e.05 585.4 Chronic kidney disease, Stage I or II Both 10 10 11 genitourinary black 10, 10 3, 2 2, 1 2, 5 3, 2 1.29 1.35 0.338 0.471 3.65 0.466 12000 0.851 748 0.999 0 2.34 5.26 65.8 -0.799 8.16 0.922 0.035 0.45 0.00131 126 -1.07 181 0.995 0.002 0.342 0.269 0.309 PRS_PLINK_1e.05 586 Other disorders of the kidney and ureters Both 37 17 11 genitourinary black 17, 37 4, 9 4, 4 4, 13 4, 11 0.622 0.408 0.127 0.896 1.86 0.9 4.36 -0.203 1.26 0.873 0.059 0.817 0.0574 8.63 1.24 1.25 0.323 0.491 3.45 0.421 121 0.876 1.53 0.568 0.246 2.4 0.0975 1600 PRS_PLINK_1e.05 586.1 Anatomical abnormatilies of kidney and ureters Both 2 2 11 genitourinary black 2, 2 1, 0 1, 2 1, 0 1, 2 -0.146 1140 1 0 0.865 0.26 1.5 -0.747 3660 1 0 0.474 0.26 3.7 PRS_PLINK_1e.05 586.11 Small kidney Both 1 0 11 genitourinary black 0, 1 PRS_PLINK_1e.05 586.12 Vesicoureteral reflux Both 2 1 11 genitourinary black 1, 2 -0.2 2960 1 0 0.819 0.797 1.56 PRS_PLINK_1e.05 586.2 Cyst of kidney, acquired Both 2 6 11 genitourinary black 6, 2 2, 0 1, 2 1, 0 2, 0 -0.321 50.8 0.995 0.002 0.726 0.0294 17.9 -0.588 23100 1 0 0.556 0.302 31.2 PRS_PLINK_1e.05 586.3 Vascular disorders of kidney/hypertrophy Both 0 1 11 genitourinary black 1, 0 PRS_PLINK_1e.05 586.4 Stricture/obstruction of ureter Both 3 6 11 genitourinary black 6, 3 2, 1 1, 0 1, 2 2, 0 -0.618 10 0.951 0.022 0.539 0.202 0.547 0.229 2240 1 0 1.26 0.721 4.37 0.353 867 1 0 1.42 1.23 1.53 -0.00852 96.9 1 0 0.992 0.726 1.04 PRS_PLINK_1e.05 587 Kidney replaced by transpant Both 1 8 11 genitourinary black 8, 1 2, 0 2, 1 2, 0 2, 0 -0.06 4500000 1 0 0.942 0.319 2.41 -0.623 1.02e+08 1 0 0.536 0.038 69.6 PRS_PLINK_1e.05 588 Disorders resulting from impaired renal function Both 2 10 11 genitourinary black 10, 2 3, 1 2, 0 2, 0 3, 1 0.372 1.86 0.842 0.075 1.45 1.4 1.49 0.379 5800 1 0 1.46 0.198 1.59 0.0987 5330 1 0 1.1 0.381 1.45 0.0723 28000 1 0 1.08 0.0252 26.2 PRS_PLINK_1e.05 588.1 Renal osteodystrophy Both 0 5 11 genitourinary black 5, 0 2 1 1 1 PRS_PLINK_1e.05 588.2 Secondary hyperparathyroidism (of renal origin) Both 2 8 11 genitourinary black 8, 2 2, 1 2, 0 2, 0 2, 1 0.175 4.24 0.967 0.015 1.19 1.16 1.21 -0.219 9010 1 0 0.803 0.75 8.09 0.325 15500 1 0 1.38 0.0808 31.5 0.0424 1360 1 0 1.04 0.488 1.9 PRS_PLINK_1e.05 589 Abnormal results of function study of kidney Both 5 8 11 genitourinary black 8, 5 2, 1 2, 1 2, 3 2, 0 -0.616 3.7 0.868 0.061 0.54 0.518 0.565 0.0245 523 1 0 1.02 0.813 1.3 0.474 1480 1 0 1.61 0.805 2.87 0.319 5450 1 0 1.38 0.55 1.7 PRS_PLINK_1e.05 590 Pyelonephritis Both 4 8 11 genitourinary black 8, 4 2, 0 2, 0 2, 1 2, 3 0.607 1.74 0.727 0.138 1.83 0.136 2 -0.00486 16.7 1 0 0.995 0.955 1.03 1.33 92.1 0.988 0.005 3.79 28.8 47.6 PRS_PLINK_1e.05 591 Urinary tract infection Both 25 31 11 genitourinary black 31, 25 8, 6 8, 5 7, 6 8, 7 -0.147 0.338 0.664 0.178 0.863 0.457 1.61 -0.176 1.24 0.887 0.052 0.838 0.0856 10.9 0.0079 1.13 0.994 0.002 1.01 0.0583 8.74 1.22 1.36 0.371 0.431 3.37 0.354 97.4 PRS_PLINK_1e.05 592 Cystitis and urethritis Both 9 15 11 genitourinary black 15, 9 4, 1 4, 5 3, 0 4, 3 0.325 0.868 0.708 0.15 1.38 0.301 9.34 1.57 2.76 0.569 0.245 4.82 0.0539 14600 -0.0622 2150 1 0 0.94 0.431 2.65 0.641 3.16 0.839 0.076 1.9 0.00545 684 PRS_PLINK_1e.05 592.1 Cystitis Both 9 14 11 genitourinary black 14, 9 4, 1 3, 5 3, 0 4, 3 0.0868 0.825 0.916 0.038 1.09 0.25 8.87 0.46 2.91 0.874 0.058 1.58 0.00567 262000 -0.0622 2150 1 0 0.94 0.431 2.65 0.641 3.16 0.839 0.076 1.9 0.00545 684 PRS_PLINK_1e.05 592.11 Acute cystitis Both 6 10 11 genitourinary black 10, 6 3, 0 2, 3 2, 2 3, 1 0.833 1.35 0.536 0.271 2.3 0.301 57.6 0.809 268 0.998 0.001 2.25 0.386 36.4 -0.0847 584 1 0 0.919 0.496 1.6 0.0198 2660 1 0 1.02 0.393 1.56 PRS_PLINK_1e.05 592.12 Chronic cystitis Both 2 3 11 genitourinary black 3, 2 1, 1 1, 0 1, 1 1, 1 -0.486 1.3e+07 1 0 0.615 0.000979 399 0.0198 73.7 1 0 1.02 0.915 1.09 0.691 695000 1 0 2 2.24e-09 1170 PRS_PLINK_1e.05 592.13 Chronic interstitial cystitis Both 1 7 11 genitourinary black 7, 1 2, 1 2, 0 1, 0 2, 0 0.0014 879 1 0 1 0.78 1.49 -0.164 4650 1 0 0.849 0.196 1.68 0.00385 31.7 1 0 1 0.991 1.02 0.174 2360 1 0 1.19 0.644 1.38 PRS_PLINK_1e.05 592.2 Urethritis and urethral syndrome Both 2 1 11 genitourinary black 1, 2 -0.0145 14 0.999 0 0.986 0.841 1.14 PRS_PLINK_1e.05 593 Hematuria Both 17 29 11 genitourinary black 29, 17 8, 6 7, 3 7, 3 7, 4 -0.495 0.401 0.216 0.665 0.609 0.273 1.23 -0.211 1.13 0.852 0.07 0.81 0.0852 9.27 -0.606 1.33 0.648 0.188 0.546 0.0279 14.6 0.205 1.22 0.866 0.062 1.23 0.0838 12 PRS_PLINK_1e.05 593.1 Gross hematuria Both 6 16 11 genitourinary black 16, 6 4, 3 4, 2 4, 0 4, 1 -0.675 0.78 0.387 0.413 0.509 0.0798 2.74 -0.563 1.86 0.763 0.118 0.57 8.45e-05 14.4 0.913 3.34 0.785 0.105 2.49 0.0121 664 -0.0204 2.41 0.993 0.003 0.98 0.0137 604 PRS_PLINK_1e.05 593.2 Microscopic hematuria Both 6 9 11 genitourinary black 9, 6 3, 3 2, 2 2, 0 2, 1 0.958 1.1 0.384 0.415 2.61 0.536 293 2.18 33.4 0.948 0.023 8.89 7.92 14200 -0.468 458 0.999 0 0.626 0.000534 6.66 0.54 1070000 1 0 1.72 1.18 2.81 PRS_PLINK_1e.05 594 Urinary calculus Both 13 43 11 genitourinary black 43, 13 11, 3 11, 1 10, 4 11, 5 0.491 0.434 0.258 0.588 1.63 0.728 3.95 -1.86 1.67 0.265 0.577 0.155 3.65e-05 3.39 1.72 1.31 0.189 0.723 5.61 0.6 903 1.52 1.92 0.429 0.367 4.58 0.11 409000 PRS_PLINK_1e.05 594.1 Calculus of kidney Both 13 43 11 genitourinary black 43, 13 11, 3 11, 1 10, 4 11, 5 0.491 0.434 0.258 0.588 1.63 0.728 3.95 -1.86 1.67 0.265 0.577 0.155 3.65e-05 3.39 1.72 1.31 0.189 0.723 5.61 0.6 903 1.52 1.92 0.429 0.367 4.58 0.11 409000 PRS_PLINK_1e.05 594.2 Calculus of lower urinary tract Both 1 4 11 genitourinary black 4, 1 1, 0 1, 1 1, 0 1, 0 2.76 2770 0.999 0 15.8 7.71e-08 6.82e+09 -0.0113 2770 1 0 0.989 0.39 1.48 PRS_PLINK_1e.05 594.3 Calculus of ureter Both 2 17 11 genitourinary black 17, 2 5, 0 4, 1 4, 0 4, 1 -0.457 1.03 0.656 0.183 0.633 0.0718 3.9 1.86 22.9 0.935 0.029 6.41 2.47e-15 1.17e+16 -4.35 18.9 0.818 0.087 0.013 0.00932 0.0185 PRS_PLINK_1e.05 594.8 Renal colic Both 1 5 11 genitourinary black 5, 1 2, 0 1, 0 1, 1 1, 0 0.0809 663 1 0 1.08 0.709 2.54 0.0189 197 1 0 1.02 0.967 1.03 PRS_PLINK_1e.05 595 Hydronephrosis Both 4 15 11 genitourinary black 15, 4 4, 0 4, 0 3, 3 4, 1 1.3 1.46 0.374 0.428 3.67 0.262 5980 3.98 107 0.97 0.013 53.5 0.000104 30400000 -2.15 95.8 0.982 0.008 0.116 3.01e-07 0.154 PRS_PLINK_1e.05 596 Other disorders of bladder Both 5 25 11 genitourinary black 25, 5 7, 0 6, 4 6, 0 6, 1 -0.16 0.649 0.805 0.094 0.852 0.217 3.07 1.64 1.69 0.331 0.48 5.18 0.369 392 0.826 3.37 0.807 0.093 2.28 0.00622 978 PRS_PLINK_1e.05 596.1 Bladder neck obstruction Both 1 2 11 genitourinary black 2, 1 1, 0 0, 1 1, 0 1, 0 -0.148 7180 1 0 0.863 0.119 2.29 -0.0109 72.2 1 0 0.989 0.793 1.19 PRS_PLINK_1e.05 596.5 Functional disorders of bladder Both 5 16 11 genitourinary black 16, 5 4, 0 4, 2 4, 2 4, 1 0.452 0.896 0.614 0.212 1.57 0.116 12.1 -0.3 7.34 0.967 0.014 0.741 0.693 0.796 0.0511 5 0.992 0.004 1.05 0.0414 1.01 5.49 17.1 0.748 0.126 241 266 767 PRS_PLINK_1e.05 597 Other disorders of urethra and urinary tract Both 3 7 11 genitourinary black 7, 3 2, 0 2, 1 1, 0 2, 1 -0.0282 1.01 0.978 0.01 0.972 0.225 4.58 -0.742 8050 1 0 0.476 0.221 1.87 0.179 7820 1 0 1.2 0.404 11.4 PRS_PLINK_1e.05 597.1 Urethral stricture (not specified as infectious) Both 2 2 11 genitourinary black 2, 2 1, 0 0, 1 1, 0 1, 0 0.0629 1920 1 0 1.06 0.751 2.26 -0.00604 323 1 0 0.994 0.92 1.08 PRS_PLINK_1e.05 597.2 Urinary complications NEC Both 1 8 11 genitourinary black 8, 1 2, 1 2, 0 2, 0 2, 0 1.02 200 0.996 0.002 2.76 0.156 40.7 -0.2 17700 1 0 0.819 0.0401 2.68 -2.94 1.42e+08 1 0 0.0531 2.61e-07 8670 6.12 11300000 1 0 454 1.83e-09 4.86e+13 PRS_PLINK_1e.05 597.8 Urethral hypermobility/ISD Both 0 2 11 genitourinary black 2, 0 1 1 1 1 PRS_PLINK_1e.05 598 Abnormal findings on examination of urine Both 0 2 11 genitourinary black 2, 0 1 1 1 1 PRS_PLINK_1e.05 598.4 Other cells and casts in urine Both 0 2 11 genitourinary black 2, 0 1 1 1 1 PRS_PLINK_1e.05 599 Other symptoms/disorders or the urinary system Both 25 35 11 genitourinary black 35, 25 9, 7 9, 9 8, 5 9, 3 -0.214 0.325 0.51 0.292 0.807 0.444 1.47 0.0298 0.96 0.975 0.011 1.03 0.182 6.06 0.0509 0.985 0.959 0.018 1.05 0.171 6.76 0.237 1.48 0.873 0.059 1.27 0.0629 214 PRS_PLINK_1e.05 599.1 Urinary obstruction Both 3 6 11 genitourinary black 6, 3 2, 1 1, 1 1, 0 2, 1 -1.87 42.5 0.965 0.016 0.154 0.000825 41.9 0.156 39300000 1 0 1.17 0.00142 1450 -0.166 4740 1 0 0.847 0.668 1.48 3.76e-06 2570 1 0 1 0.676 1.48 PRS_PLINK_1e.05 599.2 Retention of urine Both 11 27 11 genitourinary black 27, 11 7, 2 7, 2 6, 3 7, 3 -0.142 0.412 0.73 0.137 0.867 0.409 1.79 0.671 2.11 0.75 0.125 1.96 0.00476 10100 0.647 1.57 0.681 0.167 1.91 0.112 2.13 1.01 1.82 0.58 0.236 2.74 0.0895 958 PRS_PLINK_1e.05 599.3 Dysuria Both 13 27 11 genitourinary black 27, 13 7, 2 7, 4 6, 4 7, 2 -0.259 0.424 0.541 0.267 0.772 0.357 1.64 -0.146 1.39 0.916 0.038 0.864 0.0562 9.27 1.37 1.54 0.376 0.425 3.93 0.241 4.55 1.57 2.4 0.512 0.29 4.82 0.0732 7590 PRS_PLINK_1e.05 599.4 Urinary incontinence Both 6 24 11 genitourinary black 24, 6 6, 1 6, 4 6, 0 6, 1 0.614 0.766 0.423 0.373 1.85 0.513 233 1.23 2.16 0.571 0.244 3.41 0.121 4510 -1.05 4.44 0.814 0.089 0.351 8.24e-06 1120000 0.233 2.35 0.921 0.036 1.26 0.00582 90 PRS_PLINK_1e.05 599.5 Frequency of urination and polyuria Both 10 31 11 genitourinary black 31, 10 8, 2 8, 3 7, 3 8, 2 -0.111 0.489 0.82 0.086 0.895 0.338 2.44 -0.915 1.66 0.582 0.235 0.4 2.11e-05 8.77 0.51 1.7 0.764 0.117 1.66 0.0147 83.9 1.17 2.31 0.614 0.212 3.22 0.0293 73800 PRS_PLINK_1e.05 599.6 Oliguria and anuria Both 1 10 11 genitourinary black 10, 1 3, 0 2, 0 2, 0 3, 1 -0.0619 1.36 0.964 0.016 0.94 0.122 30.2 -0.0331 1300 1 0 0.967 0.417 2.08 PRS_PLINK_1e.05 599.7 Urethral discharge Both 0 6 11 genitourinary black 6, 0 2 1 1 2 PRS_PLINK_1e.05 599.8 Other symptoms involving urinary system Both 12 28 11 genitourinary black 28, 12 7, 3 7, 5 7, 1 7, 3 0.58 0.535 0.279 0.555 1.79 0.715 5.53 3.75 2.78 0.178 0.751 42.7 0.638 4.91e+08 0.732 1.85 0.693 0.16 2.08 0.00619 207000 0.885 1.69 0.601 0.221 2.42 0.138 561 PRS_PLINK_1e.05 599.9 Other abnormality of urination Both 5 21 11 genitourinary black 21, 5 6, 0 5, 1 5, 2 5, 1 -0.446 0.616 0.469 0.329 0.64 0.166 1.77 1.09 28.3 0.969 0.013 2.96 4.3e-05 114000 -5.39 10.4 0.603 0.22 0.00456 0.00275 1.99e+12 0.264 3.37 0.938 0.028 1.3 5.52e-05 629 PRS_PLINK_1e.05 600 Hyperplasia of prostate Male 3 16 11 genitourinary black 16, 3 4, 1 4, 1 4, 1 4, 0 -0.636 0.943 0.5 0.301 0.529 0.0947 13.6 -1.28 2.52 0.611 0.214 0.277 0.00311 14.6 -5.54 8.67 0.523 0.282 0.00392 2.62e-12 293 0.228 4.88 0.963 0.017 1.26 0.000915 2140 PRS_PLINK_1e.05 601 Inflammatory diseases of prostate Male 3 13 11 genitourinary black 13, 3 4, 2 3, 0 3, 1 3, 0 -0.278 0.683 0.684 0.165 0.757 0.132 2.8 1.22 184 0.995 0.002 3.37 2.2 8.27e+12 -0.865 12.6 0.945 0.024 0.421 0.000323 416 1.1 3.63 0.762 0.118 3.01 0.00561 637 PRS_PLINK_1e.05 601.1 Prostatitis Male 3 5 11 genitourinary black 5, 3 2, 2 1, 1 1, 0 1, 0 -0.837 89.8 0.993 0.003 0.433 0.109 2.24 -0.257 1180 1 0 0.774 0.555 1.18 0.0523 1100 1 0 1.05 0.259 1.2 -0.708 1200 1 0 0.493 0.0193 5.65 PRS_PLINK_1e.05 601.11 Acute prostatitis Male 1 1 11 genitourinary black 1, 1 0.00875 15.8 1 0 1.01 0.793 1.08 PRS_PLINK_1e.05 601.12 Chronic prostatitis Male 0 1 11 genitourinary black 1, 0 PRS_PLINK_1e.05 601.3 Orchitis and epididymitis Male 0 4 11 genitourinary black 4, 0 1 1 1 1 PRS_PLINK_1e.05 601.4 Balanoposthitis Male 0 3 11 genitourinary black 3, 0 1 1 1 1 PRS_PLINK_1e.05 602 Other disorders of prostate Male 1 3 11 genitourinary black 3, 1 1, 0 1, 0 1, 1 1, 0 0.0558 717 1 0 1.06 0.835 1.29 0.196 9840 1 0 1.22 0.368 12.9 PRS_PLINK_1e.05 602.3 Dysplasia of prostate Male 0 1 11 genitourinary black 1, 0 PRS_PLINK_1e.05 603 Other disorders of testis Male 0 7 11 genitourinary black 7, 0 1 2 1 2 PRS_PLINK_1e.05 603.1 Hydrocele Male 0 4 11 genitourinary black 4, 0 1 1 1 1 PRS_PLINK_1e.05 603.2 Spermatocele Male 0 5 11 genitourinary black 5, 0 1 1 1 1 PRS_PLINK_1e.05 604 Disorders of penis Male 2 6 11 genitourinary black 6, 2 1, 0 1, 1 1, 0 2, 1 0.292 194 0.999 0.001 1.34 0.658 0.756 -0.157 1100 1 0 0.855 0.422 1.51 0.0766 4870 1 0 1.08 0.503 7.44 PRS_PLINK_1e.05 604.3 Peyronie's disease Male 1 1 11 genitourinary black 1, 1 0.0116 79.5 1 0 1.01 0.904 1.2 PRS_PLINK_1e.05 605 Erectile dysfunction [ED] Male 12 11 11 genitourinary black 11, 12 3, 6 3, 2 2, 4 3, 0 -0.544 0.586 0.353 0.452 0.581 0.165 1.78 -1.33 2.16 0.537 0.27 0.264 5.01e-05 9.94 0.664 1.61 0.681 0.167 1.94 0.134 91000 -1.96 2.01 0.33 0.482 0.14 0.00131 2.22 PRS_PLINK_1e.05 608 Other disorders of male genital organs Male 3 14 11 genitourinary black 14, 3 3, 0 3, 3 3, 0 4, 0 -0.263 0.565 0.642 0.192 0.769 0.155 2.36 4.53 6.27 0.47 0.328 92.9 0.0571 138 PRS_PLINK_1e.05 609 Male infertility and abnormal spermatozoa Male 2 5 11 genitourinary black 5, 2 2, 0 1, 1 1, 0 1, 1 -0.029 4280 1 0 0.971 0.335 1.67 -0.131 3360 1 0 0.878 0.794 1.38 -4.56 14800 1 0 0.0104 7.9e-30 1.18e+20 PRS_PLINK_1e.05 609.1 Infertility, male Male 2 5 11 genitourinary black 5, 2 2, 0 1, 0 1, 1 1, 1 -0.155 4390 1 0 0.857 0.747 1.46 -0.644 4480 1 0 0.525 0.309 1.7 1.02 22500 1 0 2.77 0.0204 1090 PRS_PLINK_1e.05 609.11 Azoospermia and oligospermia Male 1 1 11 genitourinary black 1, 1 -0.00669 116 1 0 0.993 0.908 1.12 PRS_PLINK_1e.05 609.2 Abnormal spermatozoa Male 0 2 11 genitourinary black 2, 0 1 1 1 1 PRS_PLINK_1e.05 610 Benign mammary dysplasias Female 4 14 11 genitourinary black 14, 4 4, 1 3, 1 3, 1 4, 1 0.518 1.09 0.634 0.198 1.68 0.279 17.5 1.81 2.8 0.517 0.287 6.12 0.122 1850 -2.29 3.31 0.488 0.311 0.101 0.000655 10.6 0.155 4.63 0.973 0.012 1.17 0.899 1.42 PRS_PLINK_1e.05 610.1 Cystic mastopathy Female 3 8 11 genitourinary black 8, 3 2, 1 2, 0 2, 1 2, 1 -0.658 1.73 0.704 0.152 0.518 0.000184 13.4 1.44 217 0.995 0.002 4.2 0.139 261 1.4 886 0.999 0.001 4.05 1.41e-08 5.92e+13 -0.267 2780000 1 0 0.766 0.00282 74.2 PRS_PLINK_1e.05 610.2 Fibroadenosis of breast Female 0 1 11 genitourinary black 1, 0 PRS_PLINK_1e.05 610.4 Benign neoplasm of breast Female 2 14 11 genitourinary black 14, 2 4, 0 3, 1 3, 0 4, 1 0.791 1.11 0.474 0.324 2.21 0.37 26.7 0.827 6.44 0.898 0.047 2.29 0.0648 2.42 -1.18 8.63 0.891 0.05 0.306 0.208 0.44 PRS_PLINK_1e.05 610.8 Other specified benign mammary dysplasias Female 2 7 11 genitourinary black 7, 2 2, 1 2, 0 1, 0 2, 1 -1.65 3.34 0.621 0.207 0.192 0.000426 14.8 6.09 999 0.995 0.002 440 1.78e-12 1.85e+19 -0.358 4200 1 0 0.699 0.278 2.98 0.283 2110 1 0 1.33 0.413 1.84 PRS_PLINK_1e.05 611 Abnormal findings on mammogram or breast exam Both 10 17 11 genitourinary black 17, 10 5, 3 4, 4 4, 3 4, 0 0.236 0.954 0.804 0.095 1.27 0.133 428 0.89 2.14 0.677 0.169 2.44 0.0443 63600 0.44 2.48 0.859 0.066 1.55 0.00298 483 0.744 2.53 0.769 0.114 2.1 0.0277 183 PRS_PLINK_1e.05 611.1 Abnormal mammogram Both 8 14 11 genitourinary black 14, 8 4, 3 3, 4 3, 1 4, 0 0.503 1.27 0.692 0.16 1.65 0.123 1370 0.64 2.26 0.777 0.109 1.9 0.0375 45300 -0.424 5.47 0.938 0.028 0.655 0.000134 6840 0.744 2.53 0.769 0.114 2.1 0.0277 183 PRS_PLINK_1e.05 611.11 Mammographic microcalcification Both 2 6 11 genitourinary black 6, 2 2, 0 1, 2 1, 0 2, 0 0.925 8050000 1 0 2.52 1.13 11.3 -0.326 5150 1 0 0.722 0.0286 12.8 PRS_PLINK_1e.05 611.3 Lump or mass in breast Both 5 16 11 genitourinary black 16, 5 4, 2 4, 0 4, 3 4, 0 0.505 1.08 0.638 0.195 1.66 0.13 145 -0.00638 406 1 0 0.994 0.369 5.96 0.369 3.82 0.923 0.035 1.45 0.000436 898 -2.12 14.9 0.887 0.052 0.12 0.0953 0.154 PRS_PLINK_1e.05 612 Breast conditions, congenital or relating to hormones Both 2 11 11 genitourinary black 11, 2 3, 0 3, 0 2, 0 3, 2 -0.412 2.08 0.843 0.074 0.662 0.0193 25.3 -0.15 2250 1 0 0.861 0.476 1.29 PRS_PLINK_1e.05 612.1 Galactorrhea Both 0 1 11 genitourinary black 1, 0 PRS_PLINK_1e.05 612.2 Hypertrophy of breast (Gynecomastia) Both 2 6 11 genitourinary black 6, 2 2, 0 1, 0 1, 1 2, 1 -0.0451 272 1 0 0.956 0.553 1.29 -0.207 112000 1 0 0.813 0.0017 33.8 0.041 12600 1 0 1.04 1.57e-05 2.47 PRS_PLINK_1e.05 613 Other nonmalignant breast conditions Both 9 25 11 genitourinary black 25, 9 7, 4 6, 1 6, 1 6, 3 -0.304 0.551 0.582 0.235 0.738 0.251 2 -3.78 2.72 0.165 0.783 0.0228 5.48e-08 1.04 -1.95 1.82 0.284 0.547 0.142 5.59e-05 2.55 -1.07 2.26 0.635 0.197 0.342 0.0046 15.4 PRS_PLINK_1e.05 613.1 Inflammatory disease of breast Both 1 4 11 genitourinary black 4, 1 1, 0 1, 0 1, 0 1, 1 -0.101 625 1 0 0.904 0.386 2.47 -0.00435 1940 1 0 0.996 0.832 1.16 PRS_PLINK_1e.05 613.5 Mastodynia Both 3 14 11 genitourinary black 14, 3 4, 0 3, 0 3, 0 4, 3 0.715 1.34 0.593 0.227 2.04 0.283 3320 0.967 2.47 0.695 0.158 2.63 0.0527 1050 PRS_PLINK_1e.05 613.7 Other signs and symptoms in breast Both 4 7 11 genitourinary black 7, 4 2, 1 2, 1 1, 1 2, 1 -0.701 1.73 0.685 0.165 0.496 0.402 7.91 -0.0108 6930000 1 0 0.989 0.472 1.7 -0.171 1600 1 0 0.843 0.176 3.37 -0.116 645 1 0 0.89 0.36 2.05 PRS_PLINK_1e.05 613.8 Other specified disorders of breast Both 0 7 11 genitourinary black 7, 0 2 2 1 2 PRS_PLINK_1e.05 613.9 Breast disorder NOS Both 2 10 11 genitourinary black 10, 2 3, 2 2, 0 2, 0 3, 0 -3.14 3.75 0.403 0.395 0.0433 2.37e-05 7.21 0.219 1030 1 0 1.25 0.648 1.33 -0.163 787 1 0 0.85 0.427 1.4 0.332 784 1 0 1.39 0.487 1.47 PRS_PLINK_1e.05 614 Inflammatory diseases of female pelvic organs Female 7 23 11 genitourinary black 23, 7 6, 0 6, 6 5, 0 6, 1 -0.881 0.701 0.209 0.68 0.414 0.0956 1.39 0.349 1.73 0.84 0.076 1.42 0.0406 129 -2.32 3.56 0.516 0.288 0.0987 2.8e-05 53.4 PRS_PLINK_1e.05 614.1 Pelvic peritoneal adhesions, female (postoperative) (postinfection) Female 1 4 11 genitourinary black 4, 1 1, 1 1, 0 1, 0 1, 0 -0.0396 651 1 0 0.961 0.612 1.56 0.242 11800 1 0 1.27 0.268 36 -0.688 131000 1 0 0.503 1.11e-05 26 -0.333 16500 1 0 0.717 0.151 5.03 PRS_PLINK_1e.05 614.3 Pelvic inflammatory disease (PID) Female 2 4 11 genitourinary black 4, 2 1, 2 1, 0 1, 0 1, 0 7.89 2020 0.997 0.001 2660 2.34e-17 8.62e+27 0.0444 1550 1 0 1.05 0.742 2.12 -1.08 12100 1 0 0.339 0.301 71.2 -0.21 2430 1 0 0.811 0.35 1.39 PRS_PLINK_1e.05 614.31 Acute inflammatory pelvic disease Female 0 1 11 genitourinary black 1, 0 PRS_PLINK_1e.05 614.32 Chronic inflammatory pelvic disease Female 1 2 11 genitourinary black 2, 1 1, 0 1, 1 1, 0 1, 1 0.0452 739 1 0 1.05 0.724 3.41 -0.0323 1350 1 0 0.968 0.351 4.7 PRS_PLINK_1e.05 614.33 Pelvic inflammatory disease, NOS Female 1 4 11 genitourinary black 4, 1 1, 1 1, 0 1, 0 1, 0 -3.34 322 0.992 0.004 0.0355 6.79e-15 9.18e+08 -2.61 28000 1 0 0.0734 3.18e-08 736000 17.3 428000 1 0 31900000 1.64e-20 3.47e+34 1.52 29300 1 0 4.57 0.00642 4460 PRS_PLINK_1e.05 614.4 Inflammatory diseases of uterus, except cervix Female 0 3 11 genitourinary black 3, 0 1 1 1 1 PRS_PLINK_1e.05 614.5 Inflammatory disease of cervix, vagina, and vulva Female 5 23 11 genitourinary black 23, 5 6, 0 6, 4 5, 0 6, 1 -0.549 0.761 0.47 0.328 0.577 0.132 2.37 0.167 1.8 0.926 0.033 1.18 0.0176 224 -2.32 3.56 0.516 0.288 0.0987 2.8e-05 53.4 PRS_PLINK_1e.05 614.51 Cervicitis and endocervicitis Female 0 4 11 genitourinary black 4, 0 1 1 1 1 PRS_PLINK_1e.05 614.52 Vaginitis and vulvovaginitis Female 2 23 11 genitourinary black 23, 2 6, 0 6, 2 5, 0 6, 0 -0.57 0.985 0.563 0.25 0.565 0.0253 21.4 -0.364 1.82 0.841 0.075 0.695 0.00604 84 PRS_PLINK_1e.05 614.53 Cyst or abscess of Bartholin's gland Female 2 2 11 genitourinary black 2, 2 1, 0 0, 2 1, 0 1, 0 1.57 56400000 1 0 4.8 0.404 774 -0.0355 2770 1 0 0.965 0.513 1.76 PRS_PLINK_1e.05 614.54 Abscess or ulceration of vulva Female 1 1 11 genitourinary black 1, 1 0.00129 573 1 0 1 0.975 1.01 PRS_PLINK_1e.05 615 Endometriosis Female 2 18 11 genitourinary black 18, 2 5, 0 4, 1 4, 1 5, 0 0.264 0.94 0.779 0.109 1.3 0.042 918 -0.199 2.05 0.923 0.035 0.819 0.0204 39.6 -0.708 7.66 0.926 0.033 0.493 4.58e-06 84700 PRS_PLINK_1e.05 618 Genital prolapse Female 3 19 11 genitourinary black 19, 3 5, 1 5, 1 4, 0 5, 1 0.155 0.792 0.844 0.073 1.17 0.239 7.4 -1.48 2.33 0.525 0.28 0.227 0.00178 8.6 -1.07 2.18 0.624 0.205 0.343 0.00345 9.04 2.08 6.46 0.748 0.126 7.98 0.00031 1110000 PRS_PLINK_1e.05 618.1 Prolapse of vaginal walls Female 1 11 11 genitourinary black 11, 1 3, 0 3, 0 2, 1 3, 0 1.98 6.09 0.745 0.128 7.24 2.85e-05 3250000 1.32 3630 1 0 3.74 0.00125 5240 PRS_PLINK_1e.05 618.2 Uterine/Uterovaginal prolapse Female 0 6 11 genitourinary black 6, 0 2 1 1 2 PRS_PLINK_1e.05 618.5 Prolapse of vaginal vault after hysterectomy Female 0 3 11 genitourinary black 3, 0 1 1 1 1 PRS_PLINK_1e.05 618.6 Vaginal enterocele, congenital or acquired Female 2 7 11 genitourinary black 7, 2 2, 1 2, 0 1, 0 2, 1 2.49 19.2 0.897 0.047 12 10.1 14.1 -0.169 2430 1 0 0.844 0.773 1.54 -0.00658 391 1 0 0.993 0.844 1.07 0.0606 532 1 0 1.06 1.55 2.68 PRS_PLINK_1e.05 619 Noninflammatory female genital disorders Female 12 19 11 genitourinary black 19, 12 5, 1 5, 6 4, 3 5, 2 0.0246 0.568 0.965 0.015 1.02 0.365 2.93 0.877 1.49 0.555 0.256 2.4 0.221 42.6 -0.437 3.41 0.898 0.047 0.646 0.00071 1.83e+10 -0.967 3.06 0.752 0.124 0.38 0.00619 44.9 PRS_PLINK_1e.05 619.1 Noninflammatory disorders of ovary, fallopian tube, and broad ligament Female 2 12 11 genitourinary black 12, 2 3, 1 3, 0 3, 0 3, 1 -0.242 1.15 0.834 0.079 0.785 0.122 9.23 -0.522 63.9 0.993 0.003 0.593 2.34 9.25 -0.129 2140 1 0 0.879 0.361 1.33 0.178 6.07 0.977 0.01 1.2 1.06 1.38 PRS_PLINK_1e.05 619.2 Disorders of uterus, NEC Female 1 6 11 genitourinary black 6, 1 2, 0 1, 0 1, 0 2, 1 -0.0251 1270 1 0 0.975 0.372 2.46 -0.253 2910 1 0 0.776 0.175 2.4 PRS_PLINK_1e.05 619.3 Noninflammatory disorders of cervix Female 0 5 11 genitourinary black 5, 0 2 1 1 1 PRS_PLINK_1e.05 619.4 Noninflammatory disorders of vagina Female 9 18 11 genitourinary black 18, 9 5, 1 4, 3 4, 3 5, 2 -0.275 0.611 0.652 0.186 0.759 0.244 2.26 -1.89 2.56 0.461 0.336 0.152 0.0012 6.5 0.219 1.58 0.89 0.051 1.24 0.0908 19.1 -5.45 5.45 0.317 0.499 0.00429 1e-08 8.31 PRS_PLINK_1e.05 619.5 Noninflammatory disorders of vulva and perineum Female 2 12 11 genitourinary black 12, 2 3, 0 3, 2 3, 0 3, 0 -1.98 2.34 0.396 0.402 0.137 0.000188 4.03 0.0363 165 1 0 1.04 0.776 1.46 PRS_PLINK_1e.05 620 Dysplasia of female genital organs Female 0 6 11 genitourinary black 6, 0 2 1 1 2 PRS_PLINK_1e.05 620.1 Dysplasia of cervix Female 0 3 11 genitourinary black 3, 0 1 1 1 1 PRS_PLINK_1e.05 621 Endometrial hyperplasia Female 0 6 11 genitourinary black 6, 0 2 1 1 2 PRS_PLINK_1e.05 622 Polyp of female genital organs Female 3 20 11 genitourinary black 20, 3 5, 0 5, 0 5, 0 5, 3 0.633 0.941 0.501 0.3 1.88 0.369 518 1.86 3.61 0.606 0.217 6.41 0.0318 3140 PRS_PLINK_1e.05 622.1 Polyp of corpus uteri Female 2 14 11 genitourinary black 14, 2 4, 0 3, 0 3, 0 4, 2 0.281 1.01 0.782 0.107 1.32 0.275 128 3.53 6.8 0.604 0.219 34.1 0.0112 41.9 PRS_PLINK_1e.05 622.2 Mucous polyp of cervix Female 1 7 11 genitourinary black 7, 1 2, 0 2, 0 1, 0 2, 1 0.0289 101 1 0 1.03 0.784 1.39 -0.103 4170 1 0 0.902 0.768 2.95 PRS_PLINK_1e.05 623 Hypertrophy of female genital organs Female 0 13 11 genitourinary black 13, 0 4 3 3 3 PRS_PLINK_1e.05 624 Symptoms involving female genital tract Female 4 17 11 genitourinary black 17, 4 5, 0 4, 1 4, 0 4, 3 0.832 1.1 0.45 0.347 2.3 0.368 542 1.81 2.41 0.454 0.343 6.1 0.205 2020 -0.742 3.44 0.829 0.081 0.476 0.00131 184 PRS_PLINK_1e.05 624.1 Dystrophy of female genital tract Female 1 1 11 genitourinary black 1, 1 0.00445 128 1 0 1 0.188 1.07 PRS_PLINK_1e.05 624.2 Atrophy of female genital tract Female 0 1 11 genitourinary black 1, 0 PRS_PLINK_1e.05 624.9 stress incontinence, female Female 5 16 11 genitourinary black 16, 5 4, 0 4, 1 4, 2 4, 2 1.01 0.862 0.243 0.614 2.73 0.69 311 0.649 6.93 0.925 0.034 1.91 2.9e-06 727000 0.801 2.32 0.73 0.137 2.23 2.17 2.31 -1.73 5.52 0.754 0.123 0.177 0.123 435000 PRS_PLINK_1e.05 625 Pain and other symptoms associated with female genital organs Female 11 20 11 genitourinary black 20, 11 5, 0 5, 5 5, 4 5, 2 1.16 0.817 0.157 0.803 3.18 0.815 43.8 2.16 2.32 0.352 0.453 8.68 0.314 115000 2.01 2.12 0.345 0.463 7.43 0.335 9840 -0.0104 3.25 0.997 0.001 0.99 0.0119 427 PRS_PLINK_1e.05 625.1 Dyspareunia Female 4 14 11 genitourinary black 14, 4 4, 0 3, 1 3, 1 4, 2 1.38 1.03 0.181 0.743 3.99 0.758 317 0.575 3.64 0.874 0.058 1.78 0.0106 1850 1.67 130 0.99 0.004 5.3 7.78 16.5 -2.66 6.22 0.669 0.174 0.0703 0.0577 0.087 PRS_PLINK_1e.05 626 Disorders of menstruation and other abnormal bleeding from female genital tract Female 15 15 11 genitourinary black 15, 15 4, 6 4, 2 3, 1 4, 6 -0.236 0.57 0.678 0.169 0.79 0.257 2.13 0.439 1.62 0.787 0.104 1.55 0.104 161 -1.31 1.83 0.475 0.323 0.27 0.00255 3.98 -7.16 4.54 0.115 0.941 0.000777 4.39e-13 0.598 PRS_PLINK_1e.05 626.1 Irregular menstrual cycle/bleeding Female 13 15 11 genitourinary black 15, 13 4, 5 4, 2 3, 1 4, 5 -0.223 0.579 0.7 0.155 0.8 0.268 2.16 0.319 1.6 0.842 0.075 1.38 0.0946 55.6 -1.56 2.01 0.438 0.359 0.21 3.27e-07 3.41 -6.86 4.43 0.121 0.916 0.00105 1.13e-11 0.653 PRS_PLINK_1e.05 626.11 Absent or infrequent menstruation Female 7 10 11 genitourinary black 10, 7 3, 2 2, 1 2, 2 3, 2 0.653 0.97 0.501 0.3 1.92 0.436 33.7 0.835 3720000 1 0 2.31 1.06 32.2 1.95 223 0.993 0.003 7.04 1.54e-13 5.43e+14 2.16 7.08 0.76 0.119 8.67 0.000582 2630000 PRS_PLINK_1e.05 626.12 Excessive or frequent menstruation Female 9 13 11 genitourinary black 13, 9 4, 4 3, 1 3, 0 3, 4 0.102 0.81 0.899 0.046 1.11 0.273 4.97 1.44 2.45 0.555 0.255 4.23 0.118 282 -2.3 6.86 0.737 0.133 0.1 4.5e-08 316000 -0.669 3.03 0.826 0.083 0.512 2.67e-05 2020 PRS_PLINK_1e.05 626.13 Irregular menstrual cycle Female 6 13 11 genitourinary black 13, 6 4, 3 3, 0 3, 0 3, 3 -0.832 1.03 0.418 0.379 0.435 0.0608 2.19 -3.03 3.87 0.433 0.364 0.0482 6.99e-05 7.44 -8.51 20.5 0.678 0.169 0.000201 0.000129 0.000306 -4.68 4.21 0.266 0.574 0.00924 5e-11 2.64 PRS_PLINK_1e.05 626.14 Irregular menstrual bleeding Female 3 11 11 genitourinary black 11, 3 3, 0 3, 1 2, 0 3, 2 -0.158 1.54 0.918 0.037 0.854 0.0422 11 -0.0482 1720 1 0 0.953 0.87 2.38 -0.00159 1940 1 0 0.998 0.0395 10.9 PRS_PLINK_1e.05 626.15 Infertility, female, associated with anovulation Female 2 6 11 genitourinary black 6, 2 2, 1 1, 0 1, 0 2, 1 -0.586 99.3 0.995 0.002 0.556 0.147 1.54 0.208 11400 1 0 1.23 0.407 62 -0.00807 213 1 0 0.992 0.876 1.12 -0.193 3220 1 0 0.824 0.274 2.72 PRS_PLINK_1e.05 626.2 Dysmenorrhea Female 5 12 11 genitourinary black 12, 5 3, 2 3, 1 3, 0 3, 2 0.481 0.911 0.597 0.224 1.62 0.374 41.3 -3.4 23.5 0.885 0.053 0.0335 0.0272 0.0411 -0.261 57300000 1 0 0.77 1.1e-05 12900 1.66 6.34 0.794 0.1 5.25 0.000472 62600 PRS_PLINK_1e.05 626.4 Premenstrual tension syndromes Female 1 2 11 genitourinary black 2, 1 1, 0 1, 1 1, 0 1, 1 -0.0299 19900 1 0 0.971 0.138 5.54 -0.127 1880 1 0 0.881 0.736 1.54 PRS_PLINK_1e.05 626.8 Infertility, female Female 3 8 11 genitourinary black 8, 3 2, 1 2, 0 2, 0 2, 2 2.44 4.7 0.603 0.22 11.5 0.000558 101000 -0.0124 35.8 1 0 0.988 0.942 1.72 0.00091 121 1 0 1 0.882 1.17 -0.285 1230 1 0 0.752 0.704 3.83 PRS_PLINK_1e.05 627 Menopausal and postmenopausal disorders Female 7 14 11 genitourinary black 14, 7 4, 4 3, 0 3, 2 4, 1 -0.0607 0.759 0.936 0.029 0.941 0.249 3.37 0.626 6.72 0.926 0.033 1.87 7.54e-05 54000 -0.0298 1.48 0.984 0.007 0.971 0.0857 9.82 -4.06 3.02 0.179 0.748 0.0173 5.18e-05 1.05 PRS_PLINK_1e.05 627.1 Postmenopausal bleeding Female 3 8 11 genitourinary black 8, 3 2, 1 2, 0 2, 0 2, 2 2.28 16.7 0.892 0.05 9.74 7.83 12800000 0.233 5220 1 0 1.26 0.383 135 -0.085 1310 1 0 0.919 0.781 1.2 0.0208 1010 1 0 1.02 0.757 1.82 PRS_PLINK_1e.05 627.2 Symptomatic menopause Female 2 14 11 genitourinary black 14, 2 4, 1 3, 0 3, 0 4, 1 -1.32 1.59 0.405 0.392 0.266 0.00484 4.64 0.0556 22600000 1 0 1.06 0.00115 1000 0.0598 18300000 1 0 1.06 0.0483 13.2 -1.58 5.2 0.761 0.119 0.206 2.05e-07 994 PRS_PLINK_1e.05 627.21 Symptomatic artificial menopause Female 0 3 11 genitourinary black 3, 0 1 1 1 1 PRS_PLINK_1e.05 627.22 Need for Hormone replacement therapy (postmenopausal) Female 0 2 11 genitourinary black 2, 0 1 1 1 1 PRS_PLINK_1e.05 627.3 Postmenopausal atrophic vaginitis Female 2 8 11 genitourinary black 8, 2 2, 1 2, 0 2, 1 2, 0 1.88 6.58 0.775 0.111 6.54 0.000596 7.65 -0.0327 774 1 0 0.968 0.542 1.29 -0.0246 2640 1 0 0.976 0.432 2.17 -0.205 4480 1 0 0.814 0.283 1.94 PRS_PLINK_1e.05 627.4 Premenopausal menorrhagia Female 4 3 11 genitourinary black 3, 4 1, 2 1, 1 0, 1 1, 0 0.00212 13.3 1 0 1 0.679 1.49 -1.54 2460 1 0 0.213 3.93e-06 2410 0.321 5330 1 0 1.38 0.414 3.22 -0.328 1980 1 0 0.72 0.684 2.32 PRS_PLINK_1e.05 627.5 Premature menopause and other ovarian failure Female 1 3 11 genitourinary black 3, 1 1, 0 1, 1 1, 0 1, 0 0.00264 190 1 0 1 0.841 1.42 0.134 1160 1 0 1.14 0.672 1.36 PRS_PLINK_1e.05 628 Ovarian cyst Female 3 14 11 genitourinary black 14, 3 4, 1 3, 0 3, 1 4, 1 1.02 1.17 0.384 0.416 2.78 0.501 15500 -1.32 174 0.994 0.003 0.266 5.7e-23 1.56e+21 2.06 2.69 0.443 0.353 7.88 0.249 1120 3.97 11.1 0.721 0.142 53.1 9.78e-07 3.95e+09 PRS_PLINK_1e.05 634 Miscarriage; stillbirth Female 4 12 12 pregnancy complications royalblue4 12, 4 3, 2 3, 0 3, 0 3, 2 -1.15 1.18 0.326 0.486 0.315 0.00981 1.83 -2.14 65 0.974 0.012 0.118 0.0964 41800 -2.14 43.7 0.961 0.017 0.118 1.46e-05 0.135 -1.33 3.87 0.73 0.136 0.263 0.242 0.286 PRS_PLINK_1e.05 634.1 Missed abortion/Hydatidiform mole Female 0 5 12 pregnancy complications royalblue4 5, 0 2 1 1 1 PRS_PLINK_1e.05 635 Hemorrhage during pregnancy; childbirth and postpartum Female 2 8 12 pregnancy complications royalblue4 8, 2 2, 0 2, 0 2, 0 2, 2 -0.24 2.94 0.935 0.029 0.786 0.697 1.11 0.154 6250 1 0 1.17 0.224 1150 PRS_PLINK_1e.05 635.2 Antepartum hemorrhage, abruptio placentae, and placenta previa Female 1 6 12 pregnancy complications royalblue4 6, 1 2, 0 1, 0 1, 1 2, 0 -0.362 31600000 1 0 0.696 2.87e-06 43800 -6.48 3540 0.999 0.001 0.00154 3.74e-27 1.05e+23 PRS_PLINK_1e.05 635.3 Placenta previa and abruptio placenta Female 2 3 12 pregnancy complications royalblue4 3, 2 1, 0 1, 0 1, 2 1, 0 -0.866 1.4e+07 1 0 0.42 5.67e-05 8420 0.234 8330 1 0 1.26 0.442 3.77 PRS_PLINK_1e.05 636 Early or threatened labor; hemorrhage in early pregnancy Female 4 11 12 pregnancy complications royalblue4 11, 4 3, 1 3, 1 2, 0 3, 2 -0.524 1.06 0.622 0.207 0.592 0.0922 3.14 -0.993 81.2 0.99 0.004 0.371 0.327 0.418 -0.0645 1490 1 0 0.937 0.539 1.5 -6.8 47.1 0.885 0.053 0.00112 0.000744 0.00162 PRS_PLINK_1e.05 636.1 Threatened premature labor Female 0 7 12 pregnancy complications royalblue4 7, 0 2 2 1 2 PRS_PLINK_1e.05 636.2 Early onset of delivery Female 1 8 12 pregnancy complications royalblue4 8, 1 2, 0 2, 0 2, 0 2, 1 3.29 946 0.997 0.001 26.8 0.0982 267000 -0.173 6160 1 0 0.841 0.181 379 PRS_PLINK_1e.05 636.3 Hemorrhage in early pregnancy Female 3 5 12 pregnancy complications royalblue4 5, 3 2, 2 1, 0 1, 0 1, 1 -0.613 534 0.999 0 0.542 0.314 0.394 -0.0209 347 1 0 0.979 0.822 1.13 -0.0742 1480 1 0 0.929 0.814 1.57 0.088 7570 1 0 1.09 0.223 3.07 PRS_PLINK_1e.05 636.8 Cervical incompetence Female 0 2 12 pregnancy complications royalblue4 2, 0 1 1 1 1 PRS_PLINK_1e.05 637 Short gestation; low birth weight; and fetal growth retardation Both 0 1 12 pregnancy complications royalblue4 1, 0 PRS_PLINK_1e.05 642 Hypertension complicating pregnancy, childbirth, and the puerperium Female 2 11 12 pregnancy complications royalblue4 11, 2 3, 0 3, 1 2, 0 3, 1 -0.22 1.54 0.887 0.052 0.802 0.00872 24.3 0.122 533 1 0 1.13 0.271 3.73 0.447 19200000 1 0 1.56 7.99e-09 41900000 PRS_PLINK_1e.05 642.1 Preeclampsia and eclampsia Female 2 5 12 pregnancy complications royalblue4 5, 2 2, 0 1, 1 1, 0 1, 1 -0.0248 1440 1 0 0.975 0.486 1.41 -0.02 1200 1 0 0.98 0.735 1.27 -3.65e-05 9510 1 0 1 0.261 4.28 PRS_PLINK_1e.05 643 Excessive vomiting in pregnancy Female 1 7 12 pregnancy complications royalblue4 7, 1 2, 0 2, 0 1, 0 2, 1 0.0154 213 1 0 1.02 0.807 1.66 -3.21e-05 2400 1 0 1 0.328 2.75 PRS_PLINK_1e.05 643.1 Hyperemesis gravidarum Female 0 3 12 pregnancy complications royalblue4 3, 0 1 1 1 1 PRS_PLINK_1e.05 644 Anemia during pregnancy Female 1 3 12 pregnancy complications royalblue4 3, 1 1, 0 1, 0 1, 1 1, 0 0.56 28700000 1 0 1.75 0.281 14.6 -0.603 2540 1 0 0.547 0.0864 3.72 PRS_PLINK_1e.05 646 Other complications of pregnancy NEC Female 2 11 12 pregnancy complications royalblue4 11, 2 3, 0 3, 0 2, 0 3, 2 0.502 1.44 0.727 0.139 1.65 0.0482 2 0.876 15.1 0.954 0.021 2.4 6.46 7.7 PRS_PLINK_1e.05 647 Infectious and parasitic complications affecting pregnancy Female 0 3 12 pregnancy complications royalblue4 3, 0 1 1 1 1 PRS_PLINK_1e.05 647.1 Infections of genitourinary tract during pregnancy Female 1 5 12 pregnancy complications royalblue4 5, 1 2, 0 1, 0 1, 0 1, 1 -0.101 1010 1 0 0.904 0.206 4.84 -0.00844 609 1 0 0.992 0.988 1.14 PRS_PLINK_1e.05 647.3 Major puerperal infection Female 0 1 12 pregnancy complications royalblue4 1, 0 PRS_PLINK_1e.05 649 Other conditions or status of the mother complicating pregnancy, childbirth, or the puerperium Female 3 12 12 pregnancy complications royalblue4 12, 3 3, 0 3, 1 3, 0 3, 2 -0.102 1.25 0.935 0.029 0.903 0.0902 17.8 -0.204 463 1 0 0.815 0.404 1.69 -3.15 83.3 0.97 0.013 0.0428 0.0373 0.0489 PRS_PLINK_1e.05 649.1 Diabetes or abnormal glucose tolerance complicating pregnancy Female 3 13 12 pregnancy complications royalblue4 13, 3 4, 0 3, 1 3, 0 3, 2 -0.521 1.39 0.708 0.15 0.594 0.00236 14.2 0.015 176 1 0 1.02 0.723 1.7 -3.63 11 0.741 0.13 0.0266 2.38e-09 2260000 PRS_PLINK_1e.05 653 Problems associated with amniotic cavity and membranes Female 1 9 12 pregnancy complications royalblue4 9, 1 3, 0 2, 0 2, 0 2, 1 0.996 2.35 0.672 0.172 2.71 0.134 3.03 -0.155 2070000 1 0 0.857 0.187 4.27 PRS_PLINK_1e.05 654.1 Abnormality of organs and soft tissues of pelvis complicating pregnancy, childbirth, or the puerperium Female 0 4 12 pregnancy complications royalblue4 4, 0 1 1 1 1 PRS_PLINK_1e.05 654.2 Rhesus isoimmunization in pregnancy Female 0 3 12 pregnancy complications royalblue4 3, 0 1 1 1 1 PRS_PLINK_1e.05 655 Known or suspected fetal abnormality affecting management of mother Female 3 15 12 pregnancy complications royalblue4 15, 3 4, 1 4, 0 3, 0 4, 2 -0.0694 0.85 0.935 0.029 0.933 0.201 4.32 -0.938 4.2 0.823 0.084 0.391 0.00029 158 -0.125 1060 1 0 0.883 0.312 3.13 -2.94 4.97 0.554 0.256 0.053 2.67e-07 27.8 PRS_PLINK_1e.05 655.1 Abnormality in fetal heart rate or rhythm Female 2 12 12 pregnancy complications royalblue4 12, 2 3, 0 3, 0 3, 0 3, 2 -0.267 1.62 0.869 0.061 0.766 0.00451 21.1 0.858 32.1 0.979 0.009 2.36 2.24 2.49 PRS_PLINK_1e.05 656 Other perinatal conditions of fetus or newborn Both 2 13 12 pregnancy complications royalblue4 13, 2 4, 0 3, 0 3, 0 3, 2 0.574 1.59 0.718 0.144 1.78 0.0642 443 1.19 15.6 0.939 0.027 3.29 6.08 8.52 PRS_PLINK_1e.05 656.2 Respiratory conditions of fetus and newborn Both 0 3 12 pregnancy complications royalblue4 3, 0 1 1 1 1 PRS_PLINK_1e.05 669 Complications of labor and delivery NEC Female 1 15 12 pregnancy complications royalblue4 15, 1 4, 0 4, 0 3, 0 4, 1 0.299 1.33 0.822 0.085 1.35 0.0272 593 -6.63e-14 6.64 1 0 1 0.00241 909 PRS_PLINK_1e.05 671 Venous/cerebrovascular complications embolism in pregnancy and the puerperium Female 0 6 12 pregnancy complications royalblue4 6, 0 2 1 1 2 PRS_PLINK_1e.05 674 Other complications of the puerperium NEC Female 0 4 12 pregnancy complications royalblue4 4, 0 1 1 1 1 PRS_PLINK_1e.05 676 Other disorders of the breast associated with childbirth and disorders of lactation Female 0 5 12 pregnancy complications royalblue4 5, 0 2 1 1 1 PRS_PLINK_1e.05 681 Superficial cellulitis and abscess Both 13 50 13 dermatologic firebrick 50, 13 12, 2 12, 4 12, 6 13, 1 -0.0397 0.363 0.913 0.04 0.961 0.477 1.95 1.48 1.65 0.369 0.433 4.4 0.274 2110 1.12 0.978 0.252 0.599 3.07 0.58 27.6 1.09 1.56 0.484 0.315 2.99 0.115 67800000 PRS_PLINK_1e.05 681.1 Cellulitis and abscess of fingers/toes Both 4 24 13 dermatologic firebrick 24, 4 6, 1 6, 2 6, 1 6, 0 -0.381 0.633 0.547 0.262 0.683 0.1 2.15 -0.588 1.93 0.76 0.119 0.555 4.55e-05 11.9 -0.945 1.98 0.633 0.198 0.389 0.00307 8.28 -0.445 2.33 0.849 0.071 0.641 0.00279 204 PRS_PLINK_1e.05 681.2 Cellulitis and abscess of face/neck Both 2 21 13 dermatologic firebrick 21, 2 6, 0 5, 0 5, 1 5, 1 -0.0617 1.12 0.956 0.019 0.94 0.0385 38.4 -0.0718 2.14 0.973 0.012 0.931 0.0107 32.2 -0.052 2.86 0.986 0.006 0.949 0.00547 1590 PRS_PLINK_1e.05 681.3 Cellulitis and abscess of arm/hand Both 5 30 13 dermatologic firebrick 30, 5 7, 1 7, 0 7, 3 8, 1 -0.0115 0.526 0.982 0.008 0.989 0.314 2.67 0.06 1.58 0.97 0.013 1.06 0.0264 29.1 0.204 1.75 0.907 0.042 1.23 0.00722 341 0.308 1.51 0.839 0.076 1.36 0.0822 77.4 PRS_PLINK_1e.05 681.5 Cellulitis and abscess of leg, except foot Both 5 31 13 dermatologic firebrick 31, 5 7, 1 8, 0 7, 3 8, 1 0.331 0.599 0.581 0.236 1.39 0.324 7.63 0.102 1.39 0.941 0.026 1.11 0.0451 40.3 0.0412 1.45 0.977 0.01 1.04 0.0306 44.7 -0.138 1.53 0.928 0.032 0.871 0.0663 18.8 PRS_PLINK_1e.05 681.6 Cellulitis and abscess of foot, toe Both 5 26 13 dermatologic firebrick 26, 5 7, 1 6, 0 6, 3 7, 1 0.319 0.693 0.646 0.19 1.38 0.292 7.99 0.107 2.38 0.964 0.016 1.11 0.0154 2020 -0.523 1.89 0.782 0.107 0.593 0.000893 73.1 -0.0146 206 1 0 0.985 0.662 1.26 PRS_PLINK_1e.05 681.7 Cellulitis and abscess of trunk Both 2 27 13 dermatologic firebrick 27, 2 6, 0 7, 1 6, 1 7, 0 0.0491 0.635 0.938 0.028 1.05 0.12 10.8 -1.17 3.35 0.726 0.139 0.31 0.00071 2110 0.24 4.18 0.954 0.02 1.27 0.000161 1750000 PRS_PLINK_1e.05 686 Other local infections of skin and subcutaneous tissue Both 2 26 13 dermatologic firebrick 26, 2 6, 0 6, 0 6, 0 7, 2 0.443 0.69 0.52 0.284 1.56 0.324 15.7 0.653 1.55 0.674 0.171 1.92 0.177 901 PRS_PLINK_1e.05 686.1 Carbuncle and furuncle Both 1 14 13 dermatologic firebrick 14, 1 3, 0 3, 0 3, 0 4, 1 0.597 1.04 0.565 0.248 1.82 0.335 16.6 -0.366 403 0.999 0 0.693 0.878 2.95 PRS_PLINK_1e.05 686.2 Impetigo Both 0 5 13 dermatologic firebrick 5, 0 1 1 1 1 PRS_PLINK_1e.05 686.3 Pilonidal cyst Both 1 6 13 dermatologic firebrick 6, 1 1, 0 1, 0 1, 1 2, 0 -2.95 426 0.994 0.002 0.0523 3.04e-09 8480000 0.0031 5.76 1 0 1 0.938 1.08 PRS_PLINK_1e.05 686.4 Pyogenic granuloma Both 0 3 13 dermatologic firebrick 3, 0 1 1 1 1 PRS_PLINK_1e.05 686.5 Pyoderma Both 1 2 13 dermatologic firebrick 2, 1 1, 0 1, 1 1, 0 1, 1 -0.0882 21.8 0.997 0.001 0.916 0.902 1.05 -0.00655 92.6 1 0 0.993 0.898 1.1 PRS_PLINK_1e.05 687 Symptoms affecting skin Both 4 18 13 dermatologic firebrick 18, 4 4, 1 4, 1 4, 1 5, 1 -0.034 0.703 0.961 0.017 0.967 0.0384 4.08 -1.22 4.71 0.795 0.1 0.294 0.267 116 -1.5 533 0.998 0.001 0.223 0.0107 498 -1.79 4.22 0.671 0.173 0.167 2.78e-06 73.8 PRS_PLINK_1e.05 687.1 Rash and other nonspecific skin eruption Both 22 36 13 dermatologic firebrick 36, 22 8, 4 9, 4 9, 11 9, 3 0.156 0.325 0.63 0.201 1.17 0.647 2.19 -1.38 1.25 0.272 0.565 0.253 0.0168 2 0.373 0.868 0.668 0.175 1.45 0.328 6.74 -0.485 1.16 0.676 0.17 0.616 0.0556 4.3 PRS_PLINK_1e.05 687.3 Changes in skin texture Both 2 8 13 dermatologic firebrick 8, 2 2, 1 2, 0 2, 1 2, 0 1.45e-12 22.4 1 0 1 0.0272 36.8 -0.0287 2600 1 0 0.972 0.342 1.67 -0.0294 6730 1 0 0.971 0.296 2.96 1.98 2.68e+08 1 0 7.26 0.0309 13400 PRS_PLINK_1e.05 687.4 Disturbance of skin sensation Both 9 36 13 dermatologic firebrick 36, 9 8, 1 9, 3 9, 5 9, 0 0.0706 0.443 0.873 0.059 1.07 0.46 2.61 0.622 1.27 0.626 0.204 1.86 0.227 26.6 1.28 1.29 0.32 0.495 3.59 0.472 563 0.0796 1.8 0.965 0.016 1.08 0.00268 76.4 PRS_PLINK_1e.05 689 Disorder of skin and subcutaneous tissue NOS Both 16 48 13 dermatologic firebrick 48, 16 11, 3 12, 6 12, 6 12, 1 -0.0501 0.387 0.897 0.047 0.951 0.441 2.01 0.413 1.01 0.684 0.165 1.51 0.245 11.9 1.02 1.1 0.355 0.45 2.77 0.423 26.6 -0.308 1.54 0.842 0.075 0.735 0.00574 28.6 PRS_PLINK_1e.05 690 Erythematosquamous dermatosis Both 9 32 13 dermatologic firebrick 32, 9 8, 2 8, 3 8, 3 8, 1 0.153 0.477 0.748 0.126 1.17 0.461 3.1 -0.98 2.29 0.669 0.174 0.375 0.000511 4870 0.209 1.42 0.883 0.054 1.23 0.0114 55.4 -0.0482 1.83 0.979 0.009 0.953 0.0109 92.8 PRS_PLINK_1e.05 690.1 Seborrheic dermatitis Both 9 32 13 dermatologic firebrick 32, 9 8, 2 8, 3 8, 3 8, 1 0.153 0.477 0.748 0.126 1.17 0.461 3.1 -0.98 2.29 0.669 0.174 0.375 0.000511 4870 0.209 1.42 0.883 0.054 1.23 0.0114 55.4 -0.0482 1.83 0.979 0.009 0.953 0.0109 92.8 PRS_PLINK_1e.05 691 Congenital anomalies of skin Both 1 10 13 dermatologic firebrick 10, 1 3, 0 2, 0 2, 0 3, 1 1.2 5.3 0.822 0.085 3.31 0.000826 11400 0.458 1780 1 0 1.58 0.217 19.7 PRS_PLINK_1e.05 691.3 Congenital pigmentary anomalies of skin Both 0 2 13 dermatologic firebrick 2, 0 1 1 1 1 PRS_PLINK_1e.05 694 Dyschromia and Vitiligo Both 4 22 13 dermatologic firebrick 22, 4 6, 2 5, 1 5, 0 6, 1 1.03 0.806 0.201 0.697 2.8 0.712 24.9 0.428 4.2 0.919 0.037 1.53 0.000328 854000 2.11 5.01 0.673 0.172 8.25 0.00477 103000 1.71 2.31 0.458 0.339 5.53 0.18 337 PRS_PLINK_1e.05 694.1 Vitiligo Both 1 3 13 dermatologic firebrick 3, 1 1, 1 1, 0 1, 0 1, 1 -0.236 14600 1 0 0.79 0.0153 74.3 0.062 244 1 0 1.06 0.847 1.39 0.00122 17.5 1 0 1 0.964 1.07 PRS_PLINK_1e.05 694.2 Other dyschromia Both 3 19 13 dermatologic firebrick 19, 3 5, 1 5, 1 4, 0 5, 1 0.822 0.815 0.313 0.505 2.28 0.604 21.8 4.35 8.58 0.612 0.213 77.7 3.1e-05 96400000 0.925 141 0.995 0.002 2.52 0.0156 1660 -1.08 6.72 0.872 0.059 0.339 3.43e-06 15700 PRS_PLINK_1e.05 694.3 Vascular disorders of skin Both 0 1 13 dermatologic firebrick 1, 0 PRS_PLINK_1e.05 695 Erythematous conditions Both 13 33 13 dermatologic firebrick 33, 13 8, 2 8, 2 8, 5 8, 4 0.632 0.448 0.158 0.802 1.88 0.848 4.67 -1.28 2.12 0.546 0.263 0.278 0.00156 4800 0.94 1.53 0.539 0.269 2.56 0.171 980 1.39 1.39 0.317 0.498 4.03 0.426 97.8 PRS_PLINK_1e.05 695.2 Bullous dermatoses Both 0 1 13 dermatologic firebrick 1, 0 PRS_PLINK_1e.05 695.3 Rosacea Both 3 18 13 dermatologic firebrick 18, 3 5, 1 4, 0 4, 2 5, 0 -0.459 0.966 0.635 0.198 0.632 0.032 3.35 0.273 2.13 0.898 0.047 1.31 0.0433 29.7 -0.252 3.31 0.939 0.027 0.777 0.00546 329 -0.0769 3.32 0.981 0.008 0.926 0.000525 231 PRS_PLINK_1e.05 695.4 Lupus (localized and systemic) Both 3 10 13 dermatologic firebrick 10, 3 3, 1 2, 0 2, 0 3, 2 0.778 1.17 0.506 0.295 2.18 0.328 22.7 0.217 1570 1 0 1.24 0.59 3.16 -0.0397 1630 1 0 0.961 0.346 1.65 0.0389 52.9 0.999 0 1.04 0.216 2.18 PRS_PLINK_1e.05 695.41 Cutaneous lupus erythematosus Both 1 3 13 dermatologic firebrick 3, 1 1, 0 1, 1 1, 0 1, 0 -0.423 6150 1 0 0.655 0.0327 2.57 -0.015 91.6 1 0 0.985 0.714 1.2 PRS_PLINK_1e.05 695.42 Systemic lupus erythematosus Both 3 9 13 dermatologic firebrick 9, 3 3, 1 2, 0 2, 0 2, 2 0.741 1.2 0.538 0.269 2.1 0.4 15.7 0.217 1570 1 0 1.24 0.59 3.16 -0.0397 1630 1 0 0.961 0.346 1.65 0.0145 87.4 1 0 1.01 0.768 1.83 PRS_PLINK_1e.05 695.7 Prurigo and Lichen Both 3 3 13 dermatologic firebrick 3, 3 1, 0 1, 0 1, 3 1, 0 0.0457 531 1 0 1.05 0.926 1.37 0.275 2330 1 0 1.32 0.736 1.68 PRS_PLINK_1e.05 695.8 Other specified erythematous conditions Both 4 7 13 dermatologic firebrick 7, 4 2, 0 2, 1 1, 0 2, 3 1.61 1.71 0.344 0.464 5.02 0.5 98.1 -0.00343 24400 1 0 0.997 0.118 165 -0.0295 556 1 0 0.971 0.728 1.25 PRS_PLINK_1e.05 695.9 Unspecified erythematous condition Both 0 8 13 dermatologic firebrick 8, 0 2 2 2 2 PRS_PLINK_1e.05 696 Psoriasis and related disorders Both 4 9 13 dermatologic firebrick 9, 4 3, 1 2, 1 2, 0 2, 2 -0.173 1.55 0.911 0.04 0.841 0.0598 811 -0.411 2960000 1 0 0.663 0.0412 9.01 0.0932 623 1 0 1.1 0.431 2.5 0.0321 180 1 0 1.03 0.596 2.83 PRS_PLINK_1e.05 696.3 Pityriasis Both 1 3 13 dermatologic firebrick 3, 1 1, 0 1, 0 1, 1 1, 0 -1.89 2.75e+08 1 0 0.15 0.000132 67.2 -0.00655 20.1 1 0 0.993 0.907 1.08 PRS_PLINK_1e.05 696.4 Psoriasis Both 3 10 13 dermatologic firebrick 10, 3 3, 2 2, 0 2, 0 3, 1 1.35 2.09 0.519 0.285 3.85 0.261 4.29 -0.81 3660 1 0 0.445 0.00363 64.1 0.396 285 0.999 0 1.49 0.431 7.31 4.68 26.3 0.858 0.066 108 159 180 PRS_PLINK_1e.05 696.41 Psoriasis vulgaris Both 3 8 13 dermatologic firebrick 8, 3 2, 1 2, 1 2, 0 2, 1 0.89 2.16 0.68 0.168 2.44 0.105 2.74 0.609 2800 1 0 1.84 0.457 7.6 -0.145 4120 1 0 0.865 0.163 4.96 -0.0633 2050 1 0 0.939 0.324 1.59 PRS_PLINK_1e.05 696.42 Psoriatic arthropathy Both 1 2 13 dermatologic firebrick 2, 1 1, 0 1, 1 1, 0 1, 1 -0.00337 45.7 1 0 0.997 0.871 1.09 -0.00741 59.5 1 0 0.993 0.92 1.25 PRS_PLINK_1e.05 697 Sarcoidosis Both 0 4 13 dermatologic firebrick 4, 0 1 1 1 1 PRS_PLINK_1e.05 698 Pruritus and related conditions Both 3 33 13 dermatologic firebrick 33, 3 9, 0 8, 1 8, 1 8, 1 0.579 0.785 0.461 0.337 1.78 0.355 21.7 -0.292 1.84 0.874 0.058 0.747 0.00605 217 0.462 1.71 0.787 0.104 1.59 0.0245 650 0.884 2.17 0.684 0.165 2.42 0.069 22000 PRS_PLINK_1e.05 700 Corns and callosities Both 10 20 13 dermatologic firebrick 20, 10 5, 2 5, 2 5, 3 5, 3 -0.154 0.692 0.824 0.084 0.858 0.244 2.94 -6.28 6.02 0.297 0.527 0.00188 1.72e-15 12.9 -0.61 2.24 0.785 0.105 0.543 0.00495 20.4 -0.49 3.08 0.874 0.059 0.613 1.31e-08 169000 PRS_PLINK_1e.05 701 Other hypertrophic and atrophic conditions of skin Both 9 47 13 dermatologic firebrick 47, 9 11, 1 12, 4 11, 3 12, 1 0.0746 0.415 0.857 0.067 1.08 0.471 2.53 0.431 1.04 0.677 0.169 1.54 0.196 13.3 1.18 1.37 0.388 0.411 3.27 0.355 986 -0.227 1.45 0.876 0.057 0.797 0.0124 20.2 PRS_PLINK_1e.05 701.1 Keratoderma, acquired Both 2 8 13 dermatologic firebrick 8, 2 2, 0 2, 1 2, 0 2, 1 0.335 1.77 0.85 0.071 1.4 0.0589 18.1 -0.0109 15.6 0.999 0 0.989 0.879 1.08 -0.0359 4150 1 0 0.965 0.208 3.24 PRS_PLINK_1e.05 701.2 Scar conditions and fibrosis of skin Both 1 24 13 dermatologic firebrick 24, 1 6, 0 6, 1 6, 0 6, 0 0.148 0.834 0.859 0.066 1.16 0.0944 9.02 0.899 3.25 0.782 0.107 2.46 0.00114 2570 PRS_PLINK_1e.05 701.3 Circumscribed scleroderma Both 1 8 13 dermatologic firebrick 8, 1 2, 1 2, 0 2, 0 2, 0 0.0567 2300 1 0 1.06 0.651 1.81 -0.176 7720 1 0 0.838 0.165 3.53 -0.714 56200 1 0 0.489 0.000953 24.7 -0.251 26400 1 0 0.778 0.496 2.49 PRS_PLINK_1e.05 701.4 Keloid scar Both 0 5 13 dermatologic firebrick 5, 0 2 1 1 1 PRS_PLINK_1e.05 701.5 Abnormal granulation tissue Both 0 4 13 dermatologic firebrick 4, 0 1 1 1 1 PRS_PLINK_1e.05 702 Degenerative skin conditions and other dermatoses Both 11 31 13 dermatologic firebrick 31, 11 8, 4 8, 2 7, 4 8, 1 0.533 0.679 0.433 0.364 1.7 0.4 16.4 0.51 1.68 0.761 0.118 1.66 0.0164 4030 0.548 1.32 0.678 0.169 1.73 0.00407 31.4 0.982 1.52 0.52 0.284 2.67 0.132 91.5 PRS_PLINK_1e.05 702.1 Actinic keratosis Both 3 28 13 dermatologic firebrick 28, 3 7, 1 7, 1 7, 1 7, 0 -0.189 0.711 0.791 0.102 0.828 0.0706 9.5 0.599 1.53 0.694 0.158 1.82 0.0324 171 -0.402 2.29 0.861 0.065 0.669 0.00418 694 -0.518 1.82 0.776 0.11 0.595 0.0147 43.3 PRS_PLINK_1e.05 702.2 Seborrheic keratosis Both 9 32 13 dermatologic firebrick 32, 9 8, 2 8, 3 8, 1 8, 3 0.224 0.606 0.712 0.148 1.25 0.2 6.23 0.239 1.65 0.885 0.053 1.27 0.000557 151 0.157 1.34 0.906 0.043 1.17 0.0289 20.6 1.2 1.62 0.459 0.338 3.32 0.0881 1060 PRS_PLINK_1e.05 702.4 Degenerative skin disorders Both 0 1 13 dermatologic firebrick 1, 0 PRS_PLINK_1e.05 703 Diseases of nail, NOS Both 8 20 13 dermatologic firebrick 20, 8 5, 1 5, 2 5, 3 5, 2 0.511 0.728 0.483 0.316 1.67 0.375 8.69 1.97 2.36 0.404 0.394 7.15 0.185 18800 0.212 1.92 0.912 0.04 1.24 0.0572 114 7.49 8.84 0.396 0.402 1800 0.00749 2.02e+08 PRS_PLINK_1e.05 703.1 Ingrowing nail Both 5 18 13 dermatologic firebrick 18, 5 5, 1 4, 3 4, 1 5, 0 0.00806 0.846 0.992 0.003 1.01 0.171 5.9 2.42 2.46 0.325 0.489 11.3 0.382 69400 0.354 1.81 0.845 0.073 1.42 0.0902 56.3 -1.21 3.28 0.712 0.148 0.297 8.24e-05 59 PRS_PLINK_1e.05 704 Diseases of hair and hair follicles Both 9 40 13 dermatologic firebrick 40, 9 10, 1 10, 0 10, 1 10, 7 0.794 0.458 0.0829 1.081 2.21 0.997 6.34 -0.96 1.5 0.522 0.282 0.383 0.000273 7.83 0.355 1.59 0.824 0.084 1.43 0.0443 200 1.72 1.16 0.136 0.865 5.6 0.872 113 PRS_PLINK_1e.05 704.1 Alopecia Both 2 17 13 dermatologic firebrick 17, 2 5, 0 4, 1 4, 0 4, 1 -0.301 1.07 0.779 0.109 0.74 0.0452 238 -1.33 32 0.967 0.015 0.266 0.253 623 -0.86 9.71 0.929 0.032 0.423 0.404 0.442 PRS_PLINK_1e.05 704.11 Alopecia Areata Both 1 2 13 dermatologic firebrick 2, 1 1, 0 1, 1 1, 0 1, 1 -0.019 158 1 0 0.981 0.896 1.13 -0.0982 175 1 0 0.906 0.775 1.16 PRS_PLINK_1e.05 704.2 Hirsutism Both 3 3 13 dermatologic firebrick 3, 3 1, 0 1, 1 0, 1 1, 1 -3.33 2240 0.999 0.001 0.036 0.0106 2.16e+19 0.00127 41.8 1 0 1 0.867 1.24 -0.00551 26.2 1 0 0.995 0.854 1.12 0.549 29300 1 0 1.73 0.179 3.09 PRS_PLINK_1e.05 704.8 Other specified diseases of hair and hair follicles Both 7 24 13 dermatologic firebrick 24, 7 6, 1 6, 0 6, 0 6, 6 0.729 0.541 0.178 0.749 2.07 0.882 8.2 -0.192 2.1 0.927 0.033 0.826 0.00333 33.2 -0.141 2.67 0.958 0.019 0.869 0.0066 1740 1.64 1.4 0.24 0.62 5.17 0.652 260 PRS_PLINK_1e.05 705 Disorders of sweat glands Both 1 7 13 dermatologic firebrick 7, 1 2, 1 2, 0 1, 0 2, 0 -0.43 298 0.999 0 0.65 0.0508 1.82 -1.11 685 0.999 0.001 0.33 0.000706 48.5 -0.393 3580 1 0 0.675 4.35e-07 151 -5.03 16100 1 0 0.00656 2.2e-19 8.3e+18 PRS_PLINK_1e.05 705.1 Dyshidrosis Both 0 1 13 dermatologic firebrick 1, 0 PRS_PLINK_1e.05 705.3 Hidradenitis Both 0 5 13 dermatologic firebrick 5, 0 2 1 1 1 PRS_PLINK_1e.05 705.8 Hyperhidrosis Both 3 15 13 dermatologic firebrick 15, 3 4, 0 4, 0 3, 1 4, 2 0.687 1.09 0.53 0.276 1.99 0.373 198 0.376 5610000 1 0 1.46 0.0525 356 -3.68 77.6 0.962 0.017 0.0253 0.0199 0.0319 PRS_PLINK_1e.05 706 Diseases of sebaceous glands Both 19 43 13 dermatologic firebrick 43, 19 10, 2 11, 6 10, 2 11, 9 0.295 0.332 0.374 0.427 1.34 0.734 2.58 1.18 1.17 0.311 0.508 3.26 0.452 49.4 0.384 1.2 0.749 0.125 1.47 0.192 15.8 2.38 1.52 0.116 0.937 10.8 0.96 1520 PRS_PLINK_1e.05 706.1 Acne Both 6 32 13 dermatologic firebrick 32, 6 7, 1 8, 1 8, 2 8, 2 0.302 0.422 0.475 0.323 1.35 0.656 3.5 0.664 1.83 0.717 0.144 1.94 0.00322 495 0.538 2.12 0.8 0.097 1.71 0.0492 654 0.174 1.52 0.909 0.042 1.19 0.00338 51600 PRS_PLINK_1e.05 706.2 Sebaceous cyst Both 9 29 13 dermatologic firebrick 29, 9 8, 0 7, 3 7, 2 7, 4 0.563 0.579 0.331 0.481 1.76 0.648 6.33 0.307 1.66 0.853 0.069 1.36 0.000276 1810 2.27 2.14 0.289 0.539 9.67 0.397 55500 3.47 2.6 0.182 0.739 32.1 0.733 1.17e+10 PRS_PLINK_1e.05 706.3 Seborrhea Both 0 1 13 dermatologic firebrick 1, 0 PRS_PLINK_1e.05 706.8 Other specified diseases of sebaceous glands Both 9 18 13 dermatologic firebrick 18, 9 5, 1 4, 4 4, 1 5, 3 0.937 0.891 0.293 0.533 2.55 0.545 19.5 2.47 2.64 0.348 0.458 11.8 0.15 17300 0.00861 196 1 0 1.01 0.632 1.53 -0.0242 61.9 1 0 0.976 0.591 2.41 PRS_PLINK_1e.05 707 Chronic ulcer of skin Both 7 35 13 dermatologic firebrick 35, 7 9, 3 9, 1 8, 3 9, 0 -0.00994 0.477 0.983 0.007 0.99 0.382 2.5 -0.229 1.62 0.888 0.052 0.795 0.00117 23.2 0.515 1.47 0.726 0.139 1.67 0.144 39.1 -0.832 1.48 0.573 0.242 0.435 0.00759 5.81 PRS_PLINK_1e.05 707.1 Decubitus ulcer Both 2 14 13 dermatologic firebrick 14, 2 4, 1 3, 1 3, 0 4, 0 0.527 2.07 0.799 0.097 1.69 0.0132 158 -0.0677 55.1 0.999 0 0.935 0.894 7 0.0236 924 1 0 1.02 0.069 13.2 -5.35 229 0.981 0.008 0.00476 0.000397 9.37 PRS_PLINK_1e.05 707.2 Chronic ulcer of leg or foot Both 4 21 13 dermatologic firebrick 21, 4 6, 0 5, 1 5, 2 5, 1 0.398 0.665 0.549 0.26 1.49 0.18 5.97 0.597 2.63 0.82 0.086 1.82 0.0574 110 1.18 2.24 0.598 0.223 3.26 0.148 70600 -0.0565 2.04 0.978 0.01 0.945 0.017 55.5 PRS_PLINK_1e.05 707.3 Chronic ulcer of unspecified site Both 2 21 13 dermatologic firebrick 21, 2 6, 1 5, 1 5, 0 5, 0 0.515 1.05 0.622 0.206 1.67 0.0827 40.9 0.63 1.69 0.71 0.149 1.88 0.101 1150 -0.191 11.6 0.987 0.006 0.826 2.72e-08 20700000 -0.296 3.65 0.935 0.029 0.744 0.000398 1770 PRS_PLINK_1e.05 709 Diffuse diseases of connective tissue Both 5 18 13 dermatologic firebrick 18, 5 5, 1 4, 2 4, 2 5, 0 0.106 0.967 0.913 0.04 1.11 0.178 10.6 0.063 2.14 0.976 0.01 1.07 0.0212 1200 -0.288 2.43 0.906 0.043 0.75 0.0184 48.7 -1.2 4.78 0.801 0.096 0.3 1.62e-07 143000 PRS_PLINK_1e.05 709.2 Sicca syndrome Both 3 7 13 dermatologic firebrick 7, 3 2, 1 2, 1 1, 0 2, 1 -0.385 8 0.962 0.017 0.681 0.377 0.565 0.162 150 0.999 0 1.18 0.213 2.3 -0.0877 5730 1 0 0.916 0.225 1.73 0.23 2530 1 0 1.26 0.502 3.31 PRS_PLINK_1e.05 709.7 Unspecified diffuse connective tissue disease Both 3 14 13 dermatologic firebrick 14, 3 4, 1 3, 1 3, 1 4, 0 0.372 1.17 0.751 0.124 1.45 0.179 135 -0.529 1150 1 0 0.589 0.179 4.62 -0.0106 42 1 0 0.989 0.0534 18.3 -2.26 14300000 1 0 0.105 0.00146 5.85 PRS_PLINK_1e.05 710 Osteomyelitis, periostitis, and other infections involving bone Both 2 17 14 musculoskeletal darkolivegreen 17, 2 5, 1 4, 0 4, 1 4, 0 -0.0998 1.21 0.934 0.029 0.905 0.000302 75.4 -0.901 88.8 0.992 0.004 0.406 5.18e-06 32100 0.0141 378 1 0 1.01 0.471 1.38 0.0583 798 1 0 1.06 0.666 1.78 PRS_PLINK_1e.05 710.1 Osteomyelitis Both 2 18 14 musculoskeletal darkolivegreen 18, 2 5, 1 4, 0 4, 1 5, 0 -0.268 1.12 0.811 0.091 0.765 0.000571 21.2 -0.901 88.8 0.992 0.004 0.406 5.18e-06 32100 0.0224 248 1 0 1.02 0.539 1.81 0.0572 812 1 0 1.06 0.676 1.73 PRS_PLINK_1e.05 710.11 Acute osteomyelitis Both 0 8 14 musculoskeletal darkolivegreen 8, 0 2 2 2 2 PRS_PLINK_1e.05 710.12 Chronic osteomyelitis Both 0 10 14 musculoskeletal darkolivegreen 10, 0 3 2 2 3 PRS_PLINK_1e.05 710.19 Unspecified osteomyelitis Both 2 18 14 musculoskeletal darkolivegreen 18, 2 5, 1 4, 0 4, 1 5, 0 -0.588 1.18 0.617 0.21 0.555 0.00194 36.5 -1.27 7.52 0.866 0.062 0.282 0.227 0.425 -0.0565 2.19 0.979 0.009 0.945 0.0169 30.4 -0.00137 20.8 1 0 0.999 0.57 1.59 PRS_PLINK_1e.05 711 Arthropathy associated with infections Both 0 6 14 musculoskeletal darkolivegreen 6, 0 2 1 1 2 PRS_PLINK_1e.05 711.1 Pyogenic arthritis Both 0 2 14 musculoskeletal darkolivegreen 2, 0 1 1 1 1 PRS_PLINK_1e.05 712 Infective connective tissue disorders Both 0 1 14 musculoskeletal darkolivegreen 1, 0 PRS_PLINK_1e.05 713 Arthropathy associated with other disorders classified elsewhere Both 3 9 14 musculoskeletal darkolivegreen 9, 3 3, 1 2, 0 2, 1 2, 1 0.283 250 0.999 0 1.33 0.152 4.45 0.00619 58.4 1 0 1.01 0.155 3.54 -0.00755 73.9 1 0 0.992 0.456 1.52 0.156 1580 1 0 1.17 0.461 1.21 PRS_PLINK_1e.05 713.5 Arthropathy associated with neurological disorders Both 3 6 14 musculoskeletal darkolivegreen 6, 3 2, 1 1, 1 1, 1 2, 0 -0.196 740 1 0 0.822 0.401 0.893 -0.125 521 1 0 0.882 0.85 1.47 0.0086 698 1 0 1.01 0.715 1.49 -7.26e-07 3580 1 0 1 0.293 3.54 PRS_PLINK_1e.05 714 Rheumatoid arthritis and other inflammatory polyarthropathies Both 4 19 14 musculoskeletal darkolivegreen 19, 4 5, 1 5, 0 4, 0 5, 3 0.215 0.723 0.766 0.116 1.24 0.196 5.02 0.106 1.66 0.949 0.023 1.11 1.01 1.16 0.22 34.3 0.995 0.002 1.25 1.12 9.79 0.388 3.77 0.918 0.037 1.47 0.000391 803 PRS_PLINK_1e.05 714.1 Rheumatoid arthritis Both 1 13 14 musculoskeletal darkolivegreen 13, 1 4, 1 3, 0 3, 0 3, 0 -0.245 1.02 0.811 0.091 0.783 0.0291 15.9 0.00174 1680 1 0 1 0.269 1.39 -0.0453 3920 1 0 0.956 0.17 2.24 -0.265 814 1 0 0.767 0.481 0.429 PRS_PLINK_1e.05 714.2 Juvenile rheumatoid arthritis Both 0 2 14 musculoskeletal darkolivegreen 2, 0 1 1 1 1 PRS_PLINK_1e.05 715 Other inflammatory spondylopathies Both 4 8 14 musculoskeletal darkolivegreen 8, 4 2, 1 2, 0 2, 1 2, 2 3 2.74 0.274 0.562 20.1 0.543 2570000 -0.0654 499 1 0 0.937 0.437 1.36 -0.165 5940 1 0 0.848 0.639 1.84 -0.062 256 1 0 0.94 0.584 1.88 PRS_PLINK_1e.05 715.1 Sacroiliitis NEC Both 2 1 14 musculoskeletal darkolivegreen 1, 2 -0.113 30200 1 0 0.893 0.358 1.96 PRS_PLINK_1e.05 715.2 Ankylosing spondylitis Both 1 3 14 musculoskeletal darkolivegreen 3, 1 1, 0 1, 0 1, 1 1, 0 0.101 466 1 0 1.11 0.924 1.68 0.00338 169 1 0 1 0.932 1.1 PRS_PLINK_1e.05 716 Other arthropathies Both 18 42 14 musculoskeletal darkolivegreen 42, 18 10, 4 10, 3 10, 6 11, 5 0.416 0.366 0.255 0.594 1.52 0.78 3.15 -0.882 1.56 0.573 0.242 0.414 0.000145 1020 0.92 1.03 0.369 0.433 2.51 0.413 27.4 2.72 1.69 0.107 0.969 15.1 0.797 2800 PRS_PLINK_1e.05 716.1 Unspecified polyarthropathy or polyarthritis Both 1 0 14 musculoskeletal darkolivegreen 0, 1 PRS_PLINK_1e.05 716.9 Arthropathy NOS Both 18 42 14 musculoskeletal darkolivegreen 42, 18 10, 4 10, 3 10, 6 11, 5 0.416 0.366 0.255 0.594 1.52 0.78 3.15 -0.882 1.56 0.573 0.242 0.414 0.000145 1020 0.92 1.03 0.369 0.433 2.51 0.413 27.4 2.72 1.69 0.107 0.969 15.1 0.797 2800 PRS_PLINK_1e.05 717 Polymyalgia Rheumatica Both 1 3 14 musculoskeletal darkolivegreen 3, 1 1, 0 1, 0 0, 1 1, 0 0.243 9840 1 0 1.27 0.403 1.59 -0.00237 36.8 1 0 0.998 0.789 4.51 PRS_PLINK_1e.05 720 Spinal stenosis Both 1 28 14 musculoskeletal darkolivegreen 28, 1 7, 0 7, 0 7, 1 7, 0 0.0473 0.581 0.935 0.029 1.05 0.266 4.99 0.383 1.46 0.794 0.1 1.47 0.0689 46.8 PRS_PLINK_1e.05 720.1 Spinal stenosis of lumbar region Both 0 24 14 musculoskeletal darkolivegreen 24, 0 6 6 6 6 PRS_PLINK_1e.05 721 Spondylosis and allied disorders Both 8 42 14 musculoskeletal darkolivegreen 42, 8 11, 1 10, 2 10, 2 11, 3 0.502 0.537 0.349 0.457 1.65 0.558 6.15 0.947 1.78 0.596 0.225 2.58 0.0747 4440 0.582 1.2 0.629 0.202 1.79 0.134 64.4 0.809 1.38 0.558 0.254 2.25 0.127 147 PRS_PLINK_1e.05 721.1 Spondylosis without myelopathy Both 7 41 14 musculoskeletal darkolivegreen 41, 7 11, 1 10, 2 10, 1 10, 3 0.506 0.558 0.364 0.439 1.66 0.529 6.47 0.947 1.78 0.596 0.225 2.58 0.0747 4440 0.344 1.27 0.786 0.105 1.41 0.0704 73.6 0.77 1.33 0.564 0.249 2.16 0.158 98.2 PRS_PLINK_1e.05 721.2 Spondylosis with myelopathy Both 0 6 14 musculoskeletal darkolivegreen 6, 0 2 1 1 2 PRS_PLINK_1e.05 721.8 Other allied disorders of spine Both 1 4 14 musculoskeletal darkolivegreen 4, 1 1, 0 1, 0 1, 0 1, 1 0.0395 3430 1 0 1.04 0.59 2.01 -0.00283 39.5 1 0 0.997 0.952 1.05 PRS_PLINK_1e.05 722 Intervertebral disc disorders Both 4 48 14 musculoskeletal darkolivegreen 48, 4 12, 1 12, 1 12, 2 12, 0 0.42 0.683 0.538 0.269 1.52 0.139 36.2 0.0895 1.52 0.953 0.021 1.09 0.013 279 0.574 1.24 0.643 0.192 1.78 0.11 253 -0.224 1.61 0.89 0.051 0.8 0.000267 226 PRS_PLINK_1e.05 722.1 Displacement of intervertebral disc Both 1 39 14 musculoskeletal darkolivegreen 39, 1 10, 0 10, 1 9, 0 10, 0 0.172 0.598 0.773 0.112 1.19 0.172 10.7 0.2 1.48 0.892 0.049 1.22 0.0145 181 PRS_PLINK_1e.05 722.6 Degeneration of intervertebral disc Both 3 35 14 musculoskeletal darkolivegreen 35, 3 9, 1 9, 1 8, 0 9, 1 0.343 0.663 0.605 0.218 1.41 0.228 14.6 0.128 1.48 0.931 0.031 1.14 0.0356 89.2 -0.467 1.48 0.752 0.124 0.627 0.00974 23.4 0.501 1.36 0.712 0.148 1.65 0.0762 46.2 PRS_PLINK_1e.05 722.7 Intervertebral disc disorder with myelopathy Both 0 6 14 musculoskeletal darkolivegreen 6, 0 2 1 1 2 PRS_PLINK_1e.05 722.8 Postlaminectomy syndrome Both 1 9 14 musculoskeletal darkolivegreen 9, 1 3, 0 2, 0 2, 0 2, 1 -5.51 21.2 0.796 0.099 0.00406 0.00294 0.00555 -0.301 3870 1 0 0.74 0.659 2.19 PRS_PLINK_1e.05 722.9 Other and unspecified disc disorder Both 1 27 14 musculoskeletal darkolivegreen 27, 1 7, 0 7, 0 6, 0 7, 1 0.097 0.678 0.886 0.052 1.1 0.0837 7.13 -0.254 1.56 0.871 0.06 0.775 0.00541 14.4 PRS_PLINK_1e.05 723 Other disorders of cervical region Both 2 14 14 musculoskeletal darkolivegreen 14, 2 4, 0 3, 0 3, 0 4, 2 0.25 0.929 0.788 0.103 1.28 0.234 14.6 -1.11 5.74 0.847 0.072 0.33 0.289 0.413 PRS_PLINK_1e.05 723.1 Torticollis Both 0 6 14 musculoskeletal darkolivegreen 6, 0 2 1 1 2 PRS_PLINK_1e.05 724 Other and unspecified disorders of back Both 4 40 14 musculoskeletal darkolivegreen 40, 4 10, 1 10, 1 10, 1 10, 1 0.476 0.593 0.422 0.374 1.61 0.492 9.39 0.352 1.71 0.837 0.077 1.42 0.0229 155 0.286 1.31 0.828 0.082 1.33 0.0908 32.5 -0.00801 1.56 0.996 0.002 0.992 0.0166 263 PRS_PLINK_1e.05 724.1 Disorders of sacrum Both 3 31 14 musculoskeletal darkolivegreen 31, 3 8, 1 8, 1 7, 0 8, 1 0.0802 0.648 0.902 0.045 1.08 0.294 6.58 0.322 1.69 0.849 0.071 1.38 0.0222 664 -0.266 1.54 0.863 0.064 0.766 0.0401 23.6 1.55 2.96 0.601 0.221 4.71 0.0272 1.31e+13 PRS_PLINK_1e.05 724.2 Disorders of coccyx Both 0 7 14 musculoskeletal darkolivegreen 7, 0 2 2 1 2 PRS_PLINK_1e.05 724.8 Other symptoms referable to back Both 0 14 14 musculoskeletal darkolivegreen 14, 0 4 3 3 4 PRS_PLINK_1e.05 724.9 Other unspecified back disorders Both 2 15 14 musculoskeletal darkolivegreen 15, 2 4, 0 4, 1 3, 0 4, 1 0.006 1.15 0.996 0.002 1.01 0.0212 432 -12.1 158 0.939 0.027 5.54e-06 2.68e-06 1.14e-05 1.03 288 0.997 0.001 2.8 6.12 11.2 PRS_PLINK_1e.05 726 Peripheral enthesopathies and allied syndromes Both 23 23 14 musculoskeletal darkolivegreen 23, 23 5, 5 6, 9 5, 6 6, 3 0.101 0.41 0.806 0.094 1.11 0.522 2.44 3.26 2.19 0.137 0.863 26 0.977 33.7 0.0976 1.36 0.943 0.026 1.1 0.0214 15.8 -0.369 1.32 0.779 0.108 0.691 0.0461 7.61 PRS_PLINK_1e.05 726.1 Enthesopathy Both 18 23 14 musculoskeletal darkolivegreen 23, 18 5, 5 6, 7 5, 4 6, 2 -0.0163 0.422 0.969 0.014 0.984 0.449 2.21 2.69 2.05 0.19 0.722 14.7 0.645 2.22e+08 -2.59 2.5 0.3 0.523 0.0748 3.05e-06 6.77 -1.01 1.48 0.497 0.304 0.366 0.0076 4.43 PRS_PLINK_1e.05 726.2 Synoviopathy Both 2 6 14 musculoskeletal darkolivegreen 6, 2 2, 1 1, 1 1, 0 2, 0 -0.33 3060000 1 0 0.719 0.15 6.28 -0.0131 4500 1 0 0.987 0.129 1.71 12.1 5e+05 1 0 178000 1.34e-12 1.73e+23 -0.234 6710 1 0 0.791 0.0878 9.42 PRS_PLINK_1e.05 726.3 Bursitis Both 5 10 14 musculoskeletal darkolivegreen 10, 5 3, 2 2, 1 2, 1 3, 1 0.269 0.891 0.763 0.118 1.31 0.276 15.8 0.202 236 0.999 0 1.22 1.01 2.04 -0.264 63.9 0.997 0.001 0.768 0.268 0.446 -0.76 42.8 0.986 0.006 0.468 0.145 61.9 PRS_PLINK_1e.05 726.4 Calcaneal spur; Exostosis NOS Both 4 8 14 musculoskeletal darkolivegreen 8, 4 2, 0 2, 2 2, 1 2, 1 0.162 2.25 0.942 0.026 1.18 0.0232 67.9 -0.16 1090 1 0 0.852 0.746 1.15 0.0198 244 1 0 1.02 0.737 1.43 0.76 5330 1 0 2.14 0.106 9.14 PRS_PLINK_1e.05 727 Other disorders of synovium, tendon, and bursa Both 25 22 14 musculoskeletal darkolivegreen 22, 25 5, 7 5, 7 5, 9 6, 2 0.0455 0.384 0.906 0.043 1.05 0.514 2.21 1.42 1.48 0.339 0.47 4.12 0.319 3410000 0.781 1.08 0.468 0.33 2.18 0.347 31.4 -1.68 1.59 0.291 0.536 0.186 0.00143 2.35 PRS_PLINK_1e.05 727.1 Synovitis and tenosynovitis Both 11 17 14 musculoskeletal darkolivegreen 17, 11 4, 3 4, 3 4, 3 4, 2 -0.0381 0.56 0.946 0.024 0.963 0.274 2.67 -0.14 2.01 0.944 0.025 0.869 0.00656 47.8 0.225 1.93 0.908 0.042 1.25 0.0455 37.4 1.87 3.13 0.551 0.259 6.48 0.000146 3990 PRS_PLINK_1e.05 727.2 Bursitis disorders Both 0 2 14 musculoskeletal darkolivegreen 2, 0 1 1 1 1 PRS_PLINK_1e.05 727.4 Ganglion and cyst of synovium, tendon, and bursa Both 2 8 14 musculoskeletal darkolivegreen 8, 2 2, 0 2, 1 2, 1 2, 0 0.62 2.63 0.813 0.09 1.86 0.0522 136 0.218 5880 1 0 1.24 0.216 1.28 -0.0116 536 1 0 0.989 0.854 1.06 PRS_PLINK_1e.05 727.5 Rupture of synovium Both 1 1 14 musculoskeletal darkolivegreen 1, 1 -0.0386 59.9 0.999 0 0.962 0.00122 1.03 PRS_PLINK_1e.05 727.6 Rupture of tendon, nontraumatic Both 8 12 14 musculoskeletal darkolivegreen 12, 8 3, 4 3, 2 3, 2 3, 0 -0.641 0.903 0.478 0.321 0.527 1.45e-05 2.36 -0.369 2.13 0.862 0.064 0.691 0.0112 96.7 1.11 3.63 0.76 0.119 3.04 0.0192 1470 0.422 7.5 0.955 0.02 1.53 1.18 1.82 PRS_PLINK_1e.05 727.7 Contracture of tendon (sheath) Both 0 4 14 musculoskeletal darkolivegreen 4, 0 1 1 1 1 PRS_PLINK_1e.05 727.8 Plica syndrome Both 3 0 14 musculoskeletal darkolivegreen 0, 3 PRS_PLINK_1e.05 728 Disorders of muscle, ligament, and fascia Both 9 20 14 musculoskeletal darkolivegreen 20, 9 5, 1 5, 3 5, 3 5, 2 0.161 0.617 0.794 0.1 1.17 0.308 3.73 0.15 2.16 0.945 0.025 1.16 0.0232 254 0.243 2.88 0.933 0.03 1.28 0.01 363 0.979 2.33 0.675 0.171 2.66 0.0426 246 PRS_PLINK_1e.05 728.2 Laxity of ligament or hypermobility syndrome Both 1 1 14 musculoskeletal darkolivegreen 1, 1 0.00878 57.4 1 0 1.01 0.84 1.18 PRS_PLINK_1e.05 728.7 Fasciitis Both 11 14 14 musculoskeletal darkolivegreen 14, 11 4, 5 3, 1 3, 4 4, 1 -0.00621 0.636 0.992 0.003 0.994 0.315 5.34 -0.643 2.67 0.81 0.092 0.526 6.84e-05 148 1.75 4.27 0.682 0.166 5.77 0.000196 195000 0.357 2.49 0.886 0.053 1.43 0.0359 13000 PRS_PLINK_1e.05 728.71 Contracture of palmar fascia [Dupuytren's disease] Both 1 2 14 musculoskeletal darkolivegreen 2, 1 1, 0 1, 1 1, 0 1, 1 0.00698 95.5 1 0 1.01 0.835 1.06 0.0387 75.3 1 0 1.04 0.843 1.06 PRS_PLINK_1e.05 729 Other disorders of soft tissues Both 10 20 14 musculoskeletal darkolivegreen 20, 10 5, 3 5, 2 5, 5 5, 0 -0.341 0.53 0.52 0.284 0.711 0.259 1.73 -0.221 2.47 0.929 0.032 0.802 0.000657 41.7 -0.791 1.82 0.664 0.178 0.453 0.00013 9.31 -1.45 4.66 0.756 0.122 0.235 0.188 502 PRS_PLINK_1e.05 729.7 Nontraumatic compartment syndrome Both 0 1 14 musculoskeletal darkolivegreen 1, 0 PRS_PLINK_1e.05 731 Osteitis deformans and osteopathies associated with other disorders classified elsewhere Both 0 8 14 musculoskeletal darkolivegreen 8, 0 2 2 2 2 PRS_PLINK_1e.05 732 Osteochondropathies Both 1 4 14 musculoskeletal darkolivegreen 4, 1 1, 0 1, 1 1, 0 1, 0 -0.471 1120 1 0 0.624 0.0376 7.51 -0.00757 75.6 1 0 0.992 0.864 1.13 PRS_PLINK_1e.05 732.1 Juvenile osteochondrosis Both 1 0 14 musculoskeletal darkolivegreen 0, 1 PRS_PLINK_1e.05 732.7 Osteochondritis dissecans Both 0 2 14 musculoskeletal darkolivegreen 2, 0 1 1 1 1 PRS_PLINK_1e.05 733 Other disorders of bone and cartilage Both 5 30 14 musculoskeletal darkolivegreen 30, 5 8, 3 7, 1 7, 1 8, 0 -0.788 0.635 0.215 0.668 0.455 0.0455 1.42 -0.25 1.35 0.853 0.069 0.779 0.00161 8.61 -0.155 1.65 0.925 0.034 0.856 0.0315 56.9 -0.314 1.59 0.843 0.074 0.731 0.000766 1020 PRS_PLINK_1e.05 733.2 Cyst of bone Both 0 2 14 musculoskeletal darkolivegreen 2, 0 1 1 1 1 PRS_PLINK_1e.05 733.4 Aseptic necrosis of bone Both 1 5 14 musculoskeletal darkolivegreen 5, 1 2, 0 1, 0 1, 1 1, 0 -0.0149 54.6 1 0 0.985 0.458 1.53 -0.131 2020 1 0 0.877 0.389 1.24 PRS_PLINK_1e.05 733.6 Costochondritis Both 1 2 14 musculoskeletal darkolivegreen 2, 1 1, 0 0, 1 1, 0 1, 0 0.394 19500 1 0 1.48 0.294 3.09 -0.00793 35.7 1 0 0.992 0.621 1.34 PRS_PLINK_1e.05 733.8 Malunion and nonunion of fracture Both 0 12 14 musculoskeletal darkolivegreen 12, 0 3 3 3 3 PRS_PLINK_1e.05 735 Acquired foot deformities Both 11 35 14 musculoskeletal darkolivegreen 35, 11 9, 6 9, 3 8, 2 9, 0 -1.33 0.599 0.0263 1.58 0.264 0.0541 0.743 -0.666 1.14 0.56 0.252 0.514 0.0509 3.49 -1.73 2.06 0.399 0.399 0.176 0.00109 12.7 -3.34 2.2 0.129 0.89 0.0356 2.46e-09 0.902 PRS_PLINK_1e.05 735.1 Flat foot Both 2 14 14 musculoskeletal darkolivegreen 14, 2 4, 1 3, 1 3, 0 4, 0 -0.317 1.48 0.83 0.081 0.728 0.0109 10.5 -0.0403 364 1 0 0.961 0.54 1.3 -0.431 1010 1 0 0.65 0.661 1.2 -0.196 62 0.997 0.001 0.822 0.67 2.99e+09 PRS_PLINK_1e.05 735.2 Acquired toe deformities Both 3 25 14 musculoskeletal darkolivegreen 25, 3 7, 2 6, 1 6, 0 6, 0 -0.983 0.952 0.302 0.521 0.374 0.0269 2.02 -0.5 2.2 0.82 0.086 0.607 0.0035 313 0.0709 3.56 0.984 0.007 1.07 1.4e-05 57300 -0.563 1.79 0.753 0.123 0.569 0.000734 18.6 PRS_PLINK_1e.05 735.21 Hammer toe (acquired) Both 3 21 14 musculoskeletal darkolivegreen 21, 3 6, 2 5, 1 5, 0 5, 0 -0.709 0.867 0.414 0.383 0.492 0.0165 1.97 -1.5 2.11 0.477 0.321 0.223 0.00107 22.6 -1.57 3.03 0.603 0.22 0.207 2.01e-07 38.4 -0.381 1.77 0.83 0.081 0.683 0.0122 11.6 PRS_PLINK_1e.05 735.23 Hallux rigidus Both 0 8 14 musculoskeletal darkolivegreen 8, 0 2 2 2 2 PRS_PLINK_1e.05 735.3 Hallux valgus (Bunion) Both 6 26 14 musculoskeletal darkolivegreen 26, 6 7, 5 6, 1 6, 0 7, 0 -1.48 0.827 0.0743 1.129 0.229 0.0169 1.01 -1.35 1.67 0.421 0.376 0.26 1.47e-06 43 0.242 2.43 0.921 0.036 1.27 0.00194 1230 -2.1 1.78 0.236 0.626 0.122 0.00163 1.83 PRS_PLINK_1e.05 736 Other acquired deformities of limbs Both 7 34 14 musculoskeletal darkolivegreen 34, 7 9, 4 8, 3 8, 0 9, 0 -1.42 0.79 0.0725 1.14 0.242 0.00798 0.92 -1.08 1.36 0.425 0.372 0.338 0.00085 3.76 0.305 2.28 0.894 0.049 1.36 0.00566 6520 -2.01 1.6 0.209 0.679 0.134 0.000555 1.85 PRS_PLINK_1e.05 736.2 Acquired deformities of finger Both 1 5 14 musculoskeletal darkolivegreen 5, 1 2, 1 1, 0 1, 0 1, 0 0.118 151 0.999 0 1.13 4.28e-05 20900 -0.632 2060 1 0 0.531 1.18e-12 1.04e+13 0.326 501 0.999 0 1.39 0.00572 7610 -0.0856 2780 1 0 0.918 0.151 3.91 PRS_PLINK_1e.05 736.4 Genu valgum or varum (acquired) Both 0 1 14 musculoskeletal darkolivegreen 1, 0 PRS_PLINK_1e.05 736.6 Unequal leg length (acquired) Both 0 6 14 musculoskeletal darkolivegreen 6, 0 2 1 1 2 PRS_PLINK_1e.05 737 Curvature of spine Both 2 18 14 musculoskeletal darkolivegreen 18, 2 5, 1 4, 0 4, 0 5, 0 -0.878 0.805 0.275 0.56 0.416 0.0421 1.43 0.0726 2.57 0.977 0.01 1.08 0.0144 234 0.279 1360 1 0 1.32 0.853 1.9 0.132 11.9 0.991 0.004 1.14 9.31e-06 30400 PRS_PLINK_1e.05 737.1 Kyphosis (acquired) Both 1 7 14 musculoskeletal darkolivegreen 7, 1 2, 1 2, 0 1, 0 2, 0 0.0554 724 1 0 1.06 0.226 1.94 0.135 1850 1 0 1.14 0.643 1.19 -0.0252 68.1 1 0 0.975 0.461 1.99 -0.00114 22.7 1 0 0.999 0.776 1.14 PRS_PLINK_1e.05 737.2 Lordosis (acquired) Both 0 1 14 musculoskeletal darkolivegreen 1, 0 PRS_PLINK_1e.05 737.3 Kyphoscoliosis and scoliosis Both 1 13 14 musculoskeletal darkolivegreen 13, 1 4, 0 3, 0 3, 0 3, 0 -0.68 1.39 0.623 0.205 0.506 0.0214 10.3 PRS_PLINK_1e.05 738 Other acquired musculoskeletal deformity Both 3 24 14 musculoskeletal darkolivegreen 24, 3 6, 2 6, 0 6, 1 6, 0 -1.48 1.07 0.169 0.773 0.228 0.00356 2.69 -1.25 2.27 0.582 0.235 0.287 0.000223 7.97 -0.976 1.88 0.604 0.219 0.377 0.0128 22.4 -0.423 1.84 0.818 0.087 0.655 0.000404 12.4 PRS_PLINK_1e.05 738.4 Acquired spondylolisthesis Both 0 12 14 musculoskeletal darkolivegreen 12, 0 3 3 3 3 PRS_PLINK_1e.05 739 Contracture of joint Both 2 10 14 musculoskeletal darkolivegreen 10, 2 3, 2 2, 0 2, 0 3, 0 -0.269 1.65 0.87 0.06 0.764 0.0127 10.9 0.403 76700000 1 0 1.5 0.0121 2610000 0.0275 1770 1 0 1.03 0.239 1.45 -1.38 962 0.999 0 0.251 0.138 0.0427 PRS_PLINK_1e.05 740 Osteoarthrosis Both 23 40 14 musculoskeletal darkolivegreen 40, 23 9, 5 10, 6 10, 7 10, 5 0.0993 0.318 0.755 0.122 1.1 0.614 2.02 0.273 1.03 0.791 0.102 1.31 0.228 10.1 0.688 1.01 0.495 0.305 1.99 0.345 17 1.03 1.14 0.367 0.435 2.79 0.422 24.4 PRS_PLINK_1e.05 740.1 Osteoarthritis; localized Both 12 30 14 musculoskeletal darkolivegreen 30, 12 8, 3 7, 3 7, 3 8, 3 0.0659 0.384 0.864 0.064 1.07 0.532 2.19 0.15 1.38 0.913 0.04 1.16 0.11 51.8 0.233 1.25 0.852 0.07 1.26 0.15 14.5 -0.395 1.17 0.734 0.134 0.673 0.0484 4.94 PRS_PLINK_1e.05 740.11 Osteoarthrosis, localized, primary Both 9 29 14 musculoskeletal darkolivegreen 29, 9 8, 1 7, 2 7, 3 7, 3 1.08 0.633 0.0867 1.062 2.96 0.993 15.9 0.553 1.78 0.755 0.122 1.74 0.0225 301 1.43 1.46 0.327 0.486 4.19 0.428 249000 1.33 1.71 0.437 0.359 3.77 0.0282 34900 PRS_PLINK_1e.05 740.12 Osteoarthrosis, localized, secondary Both 1 3 14 musculoskeletal darkolivegreen 3, 1 1, 0 1, 1 1, 0 1, 0 0.0186 5580 1 0 1.02 0.689 1.09 -0.00549 49.6 1 0 0.995 0.833 1.05 PRS_PLINK_1e.05 740.2 Osteoarthrosis, generalized Both 4 10 14 musculoskeletal darkolivegreen 10, 4 3, 1 2, 1 2, 0 3, 2 -0.38 1.56 0.808 0.093 0.684 0.0277 16.2 -0.0352 687 1 0 0.965 0.508 1.15 -0.000364 125 1 0 1 0.94 1.06 0.0385 568 1 0 1.04 0.463 1.91 PRS_PLINK_1e.05 740.3 Osteoarthrosis involving more than one site, but not specified as generalized Both 2 1 14 musculoskeletal darkolivegreen 1, 2 -0.00866 699 1 0 0.991 0.99 1.13 PRS_PLINK_1e.05 740.9 Osteoarthrosis NOS Both 23 40 14 musculoskeletal darkolivegreen 40, 23 9, 5 10, 6 10, 7 10, 5 0.0993 0.318 0.755 0.122 1.1 0.614 2.02 0.273 1.03 0.791 0.102 1.31 0.228 10.1 0.688 1.01 0.495 0.305 1.99 0.345 17 1.03 1.14 0.367 0.435 2.79 0.422 24.4 PRS_PLINK_1e.05 741 Symptoms and disorders of the joints Both 15 46 14 musculoskeletal darkolivegreen 46, 15 11, 6 11, 6 11, 1 12, 2 -0.303 0.318 0.341 0.468 0.739 0.401 1.31 -0.215 0.952 0.822 0.085 0.807 0.13 4.4 -0.578 1.14 0.612 0.213 0.561 0.0541 4.17 -1.43 1.37 0.298 0.526 0.24 0.0115 2.55 PRS_PLINK_1e.05 741.1 Ankylosis of joint Both 1 3 14 musculoskeletal darkolivegreen 3, 1 1, 1 1, 0 1, 0 1, 1 0.0142 674 1 0 1.01 0.889 1.31 -0.0312 261 1 0 0.969 0.858 1.17 -0.0117 69.2 1 0 0.988 0.872 1.05 PRS_PLINK_1e.05 741.2 Stiffness of joint Both 2 17 14 musculoskeletal darkolivegreen 17, 2 5, 2 4, 0 4, 0 4, 0 -1.07 1.36 0.432 0.365 0.344 0.000136 9.11 -0.579 2.18 0.791 0.102 0.56 0.00806 15.5 -1.64 4.13 0.692 0.16 0.195 1.56e-05 258 -0.462 2.44 0.85 0.071 0.63 0.000127 516 PRS_PLINK_1e.05 741.3 Difficulty in walking Both 1 23 14 musculoskeletal darkolivegreen 23, 1 6, 1 6, 0 5, 0 6, 0 -0.00871 0.924 0.992 0.003 0.991 0.0198 36.6 -0.696 3.82 0.856 0.068 0.499 0.000194 769 0.191 3.38 0.955 0.02 1.21 0.00134 1860 0.395 2.07 0.848 0.071 1.49 0.00411 95.5 PRS_PLINK_1e.05 741.4 Joint effusions Both 9 32 14 musculoskeletal darkolivegreen 32, 9 7, 3 8, 4 8, 1 8, 1 0.000801 0.421 0.998 0.001 1 0.464 2.17 2.26 1.96 0.249 0.604 9.57 0.0661 9440 0.855 1.86 0.645 0.19 2.35 0.12 4710 -1.53 1.99 0.441 0.355 0.216 0.00148 26.2 PRS_PLINK_1e.05 741.5 Hemarthrosis Both 1 2 14 musculoskeletal darkolivegreen 2, 1 1, 1 1, 0 1, 1 1, 0 -0.00108 9.35 1 0 0.999 0.985 1.01 0.00441 37.8 1 0 1 0.955 1.05 PRS_PLINK_1e.05 741.6 Villonodular synovitis Both 1 1 14 musculoskeletal darkolivegreen 1, 1 -0.00153 307 1 0 0.998 0.972 1.06 PRS_PLINK_1e.05 742 Derangement of joint, non-traumatic Both 7 45 14 musculoskeletal darkolivegreen 45, 7 11, 2 11, 2 11, 2 11, 1 -0.0868 0.406 0.831 0.081 0.917 0.402 2.1 -0.296 1.35 0.827 0.083 0.744 0.0216 9.74 0.482 1.14 0.671 0.173 1.62 0.19 21.2 -1.3 1.64 0.427 0.369 0.272 0.00254 4.67 PRS_PLINK_1e.05 742.1 Loose body in joint Both 1 3 14 musculoskeletal darkolivegreen 3, 1 1, 1 1, 0 1, 0 1, 1 -0.716 6420 1 0 0.489 0.00161 82.6 0.0189 54.8 1 0 1.02 0.947 1.07 -0.637 310000 1 0 0.529 6.53e-05 4280 PRS_PLINK_1e.05 742.2 Pathological, developmental or recurrent dislocation Both 0 3 14 musculoskeletal darkolivegreen 3, 0 1 1 1 1 PRS_PLINK_1e.05 742.8 Articular cartilage disorder Both 1 5 14 musculoskeletal darkolivegreen 5, 1 1, 1 1, 0 1, 0 1, 0 -0.025 71.7 1 0 0.975 0.315 3.25 0.000626 86 1 0 1 0.973 1.02 0.00183 33.8 1 0 1 0.958 1.06 0.000892 275 1 0 1 0.992 1.01 PRS_PLINK_1e.05 742.9 Other derangement of joint Both 5 43 14 musculoskeletal darkolivegreen 43, 5 10, 1 11, 1 10, 2 11, 1 0.346 0.531 0.515 0.289 1.41 0.487 6.19 -0.0229 1.51 0.988 0.005 0.977 0.00856 575 0.752 1.27 0.555 0.256 2.12 0.0184 53.9 0.448 1.73 0.796 0.099 1.56 0.0013 302 PRS_PLINK_1e.05 743 Osteoporosis, osteopenia and pathological fracture Both 12 51 14 musculoskeletal darkolivegreen 51, 12 12, 4 13, 2 12, 4 13, 2 -0.163 0.403 0.685 0.164 0.849 0.37 1.93 -0.483 1.11 0.663 0.179 0.617 0.071 5.25 0.672 1.17 0.565 0.248 1.96 0.187 47.8 0.779 1.87 0.677 0.169 2.18 0.0495 1310 PRS_PLINK_1e.05 743.1 Osteoporosis Both 6 22 14 musculoskeletal darkolivegreen 22, 6 6, 2 5, 1 5, 2 6, 1 0.824 0.841 0.327 0.485 2.28 0.543 16 0.758 2.48 0.76 0.119 2.13 0.00779 131000 -0.0469 1.43 0.974 0.011 0.954 0.045 33.4 -5.14 5.09 0.312 0.505 0.00585 7.02e-09 19 PRS_PLINK_1e.05 743.11 Osteoporosis NOS Both 6 21 14 musculoskeletal darkolivegreen 21, 6 6, 2 5, 1 5, 2 5, 1 0.824 0.841 0.327 0.485 2.28 0.543 16 0.758 2.48 0.76 0.119 2.13 0.00779 131000 -0.0469 1.43 0.974 0.011 0.954 0.045 33.4 -5.14 5.09 0.312 0.505 0.00585 7.02e-09 19 PRS_PLINK_1e.05 743.12 Senile osteoporosis Both 0 4 14 musculoskeletal darkolivegreen 4, 0 1 1 1 1 PRS_PLINK_1e.05 743.13 Other specified osteoporosis Both 3 4 14 musculoskeletal darkolivegreen 4, 3 1, 2 1, 1 1, 0 1, 0 -0.127 92.3 0.999 0 0.881 0.192 2.61 0.229 7700000 1 0 1.26 0.00155 13400 -0.0204 5940 1 0 0.98 0.424 2.1 0.021 3000 1 0 1.02 0.465 2.38 PRS_PLINK_1e.05 743.2 Pathologic fracture Both 2 8 14 musculoskeletal darkolivegreen 8, 2 2, 0 2, 0 2, 2 2, 0 -0.554 3.81 0.884 0.053 0.574 0.00117 386 0.107 810 1 0 1.11 0.871 1.63 PRS_PLINK_1e.05 743.21 Pathologic fracture of vertebrae Both 1 4 14 musculoskeletal darkolivegreen 4, 1 1, 0 1, 0 1, 0 1, 1 0.00302 751 1 0 1 0.703 2.11 0.000387 10.7 1 0 1 0.957 1.05 PRS_PLINK_1e.05 743.22 Pathologic fracture of femur Both 0 1 14 musculoskeletal darkolivegreen 1, 0 PRS_PLINK_1e.05 743.4 Stress fracture Both 2 6 14 musculoskeletal darkolivegreen 6, 2 2, 1 1, 0 1, 0 2, 1 0.0229 465 1 0 1.02 0.749 1.59 0.143 62100 1 0 1.15 3.45e-07 1.83e+17 -0.0363 15300 1 0 0.964 0.000207 7750 0.186 4030 1 0 1.2 0.533 2.41 PRS_PLINK_1e.05 743.9 Osteopenia or other disorder of bone and cartilage Both 9 46 14 musculoskeletal darkolivegreen 46, 9 12, 3 11, 2 11, 1 12, 3 -0.164 0.414 0.692 0.16 0.849 0.372 1.94 0.323 1.28 0.802 0.096 1.38 0.124 111 -0.37 1.17 0.751 0.124 0.691 0.0379 11.1 -0.0657 1.43 0.963 0.016 0.936 0.0473 34.9 PRS_PLINK_1e.05 745 Pain in joint Both 42 22 14 musculoskeletal darkolivegreen 22, 42 5, 15 5, 9 5, 13 6, 5 -0.196 0.315 0.534 0.272 0.822 0.453 1.47 -0.376 0.907 0.679 0.168 0.687 0.126 3.42 0.314 1.01 0.756 0.122 1.37 0.211 15.4 -0.661 0.95 0.487 0.313 0.516 0.0931 2.77 PRS_PLINK_1e.05 747 Cardiac and circulatory congenital anomalies Both 3 23 15 congenital anomalies mediumspringgreen 23, 3 6, 1 6, 0 5, 1 6, 1 0.249 0.616 0.686 0.164 1.28 0.398 5.02 1.07 2.98 0.718 0.144 2.93 0.00834 1700 -0.06 2.13 0.978 0.01 0.942 0.864 1.12 -0.0564 2.25 0.98 0.009 0.945 0.0316 19.3 PRS_PLINK_1e.05 747.1 Cardiac congenital anomalies Both 3 17 15 congenital anomalies mediumspringgreen 17, 3 5, 1 4, 0 4, 1 4, 1 0.379 0.672 0.572 0.242 1.46 0.467 6.26 1.52 14.8 0.918 0.037 4.55 1.56e-07 1.63e+08 -0.968 2.69 0.719 0.143 0.38 0.337 0.493 5.12 17.9 0.775 0.111 168 1.47e-05 217 PRS_PLINK_1e.05 747.11 Cardiac shunt/ heart septal defect Both 1 9 15 congenital anomalies mediumspringgreen 9, 1 3, 0 2, 0 2, 0 2, 1 -0.153 2.68 0.954 0.02 0.858 0.00738 61.4 -0.49 330 0.999 0.001 0.613 0.125 1.8 PRS_PLINK_1e.05 747.12 Valvular heart disease/ heart chambers Both 2 4 15 congenital anomalies mediumspringgreen 4, 2 1, 0 1, 0 1, 0 1, 2 -0.163 615 1 0 0.85 0.83 1.53 -17.4 37300 1 0 2.86e-08 2.05e-30 9.4e+07 PRS_PLINK_1e.05 747.13 Congenital anomalies of great vessels Both 0 3 15 congenital anomalies mediumspringgreen 3, 0 1 1 1 1 PRS_PLINK_1e.05 747.2 Congenital anomalies of peripheral vascular system Both 0 7 15 congenital anomalies mediumspringgreen 7, 0 2 2 1 2 PRS_PLINK_1e.05 748 Anomalies of respiratory system, congenital Both 0 3 15 congenital anomalies mediumspringgreen 3, 0 1 1 1 1 PRS_PLINK_1e.05 749 Congenital anomalies of face and neck Both 2 12 15 congenital anomalies mediumspringgreen 12, 2 2, 1 3, 0 3, 1 3, 0 0.0144 0.987 0.988 0.005 1.01 0.152 5.1 -0.0424 817 1 0 0.958 0.635 1.4 0.417 3820 1 0 1.52 0.483 18.6 -0.181 3760 1 0 0.835 0.109 4.18 PRS_PLINK_1e.05 749.1 Cleft palate Both 0 2 15 congenital anomalies mediumspringgreen 2, 0 1 1 1 1 PRS_PLINK_1e.05 749.2 Congenital anomalies of skull and face bones Both 0 2 15 congenital anomalies mediumspringgreen 2, 0 1 1 1 1 PRS_PLINK_1e.05 750 Digestive congenital anomalies Both 2 13 15 congenital anomalies mediumspringgreen 13, 2 3, 0 3, 0 3, 1 3, 1 2.93 3.2 0.36 0.444 18.8 0.067 25400 -0.252 1350 1 0 0.778 0.39 1.47 -0.577 8260 1 0 0.561 0.0166 5.9 PRS_PLINK_1e.05 750.1 Upper gastrointestinal congenital anomalies Both 0 4 15 congenital anomalies mediumspringgreen 4, 0 1 1 1 1 PRS_PLINK_1e.05 750.11 Esophageal atresia/tracheoesophageal fistula Both 0 2 15 congenital anomalies mediumspringgreen 2, 0 1 1 1 1 PRS_PLINK_1e.05 750.13 Congenital anomalies of mouth/tongue Both 0 2 15 congenital anomalies mediumspringgreen 2, 0 1 1 1 1 PRS_PLINK_1e.05 750.14 Congenital anomalies of esophagus Both 0 1 15 congenital anomalies mediumspringgreen 1, 0 PRS_PLINK_1e.05 750.2 Lower gastrointestinal congenital anomalies Both 2 11 15 congenital anomalies mediumspringgreen 11, 2 3, 0 3, 0 2, 1 3, 1 0.281 1.35 0.834 0.079 1.32 0.204 724 0.00764 286 1 0 1.01 0.931 1.17 -0.133 2830 1 0 0.875 0.68 2.37 PRS_PLINK_1e.05 750.21 Congenital anomalies of intestine Both 1 6 15 congenital anomalies mediumspringgreen 6, 1 2, 0 1, 1 1, 0 2, 0 -17.3 252 0.945 0.024 3.11e-08 2.49e-28 1.97e+12 -1.14 7980 1 0 0.319 4.88e-06 15300000 PRS_PLINK_1e.05 750.22 Congenital anomaly of gallbladder, bile ducts, liver, pancreas Both 1 9 15 congenital anomalies mediumspringgreen 9, 1 3, 0 2, 0 2, 0 2, 1 0.0722 1.27 0.955 0.02 1.07 0.165 10.2 -0.272 2770 1 0 0.762 0.738 2.12 PRS_PLINK_1e.05 751 Genitourinary congenital anomalies Both 8 28 15 congenital anomalies mediumspringgreen 28, 8 6, 0 7, 7 7, 0 7, 1 0.157 0.467 0.737 0.132 1.17 0.505 3.01 1.68 1.5 0.262 0.582 5.38 0.563 720 0.601 2.06 0.771 0.113 1.82 0.0384 2.54e+08 PRS_PLINK_1e.05 751.1 Congenital anomalies of genital organs Both 3 5 15 congenital anomalies mediumspringgreen 5, 3 1, 1 1, 2 1, 0 1, 0 0.0231 77 1 0 1.02 0.748 1.56 -0.477 1460 1 0 0.621 0.606 1.29 -0.298 6820 1 0 0.742 0.0658 2.31 0.0118 51.6 1 0 1.01 0.872 1.12 PRS_PLINK_1e.05 751.11 Congenital anomalies of female genital organs Female 2 3 15 congenital anomalies mediumspringgreen 3, 2 1, 1 1, 0 0, 1 1, 0 -0.0919 1180 1 0 0.912 0.333 1.46 -0.654 2630 1 0 0.52 0.0128 0.815 -0.0378 997 1 0 0.963 0.602 1.47 -0.278 4860 1 0 0.758 0.0867 5 PRS_PLINK_1e.05 751.12 Congenital anomalies of male genital organs Male 0 4 15 congenital anomalies mediumspringgreen 4, 0 1 1 1 1 PRS_PLINK_1e.05 751.2 Congenital anomalies of urinary system Both 6 7 15 congenital anomalies mediumspringgreen 7, 6 2, 0 2, 5 1, 1 2, 0 0.141 3 0.962 0.017 1.15 2.81e-06 1020 -12.8 339 0.97 0.013 2.75e-06 1.37e-08 3.61e-08 -0.0475 8650 1 0 0.954 0.146 5.62 PRS_PLINK_1e.05 751.21 Cystic kidney disease Both 2 4 15 congenital anomalies mediumspringgreen 4, 2 1, 0 1, 2 1, 0 1, 0 0.00515 357 1 0 1.01 0.829 1.19 -2.04 3.83e+08 1 0 0.13 2.38e-05 1670 PRS_PLINK_1e.05 751.22 Other specified congenital anomalies of kidney Both 5 3 15 congenital anomalies mediumspringgreen 3, 5 1, 1 1, 1 1, 3 1, 1 0.147 754 1 0 1.16 0.932 4.01 -0.462 15300 1 0 0.63 7.32e-05 2.96 -1.07 5250 1 0 0.344 0.294 3.13 PRS_PLINK_1e.05 751.3 Obstructive genitourinary defect Both 1 4 15 congenital anomalies mediumspringgreen 4, 1 1, 0 1, 0 1, 0 1, 1 0.174 5930 1 0 1.19 0.275 9.9 0.00552 55.7 1 0 1.01 0.944 1.09 PRS_PLINK_1e.05 752 Nervous system congenital anomalies Both 1 15 15 congenital anomalies mediumspringgreen 15, 1 4, 0 4, 0 3, 0 4, 1 0.609 1.42 0.669 0.175 1.84 0.132 41400 -2.14 38.7 0.956 0.02 0.118 0.000127 102 PRS_PLINK_1e.05 752.1 Neural tube defects Both 0 13 15 congenital anomalies mediumspringgreen 13, 0 4 3 3 3 PRS_PLINK_1e.05 752.11 Spina bifida Both 0 2 15 congenital anomalies mediumspringgreen 2, 0 1 1 1 1 PRS_PLINK_1e.05 752.2 Other specified congenital anomalies of nervous system Both 0 4 15 congenital anomalies mediumspringgreen 4, 0 1 1 1 1 PRS_PLINK_1e.05 753 Congenital anomalies of the eye Both 1 8 15 congenital anomalies mediumspringgreen 8, 1 2, 0 2, 0 2, 0 2, 1 0.731 15.5 0.962 0.017 2.08 0.677 6.66 -0.0247 1500 1 0 0.976 0.737 1.25 PRS_PLINK_1e.05 753.1 Congenital cataract and lens anomalies Both 0 1 15 congenital anomalies mediumspringgreen 1, 0 PRS_PLINK_1e.05 753.2 Congenital anomalies of posterior segment of eye Both 0 3 15 congenital anomalies mediumspringgreen 3, 0 1 1 1 1 PRS_PLINK_1e.05 754 Congenital musculoskeletal deformities of spine Both 1 11 15 congenital anomalies mediumspringgreen 11, 1 3, 0 3, 0 2, 0 3, 1 0.19 2.77 0.945 0.024 1.21 0.0133 118 -0.219 1870000 1 0 0.803 0.205 3.99 PRS_PLINK_1e.05 754.1 Lumbosacral spondylolysis, congenital Both 1 2 15 congenital anomalies mediumspringgreen 2, 1 1, 0 1, 1 1, 0 1, 1 0.134 2290 1 0 1.14 0.424 1.72 -0.000734 48.9 1 0 0.999 0.981 1.02 PRS_PLINK_1e.05 754.2 Spondylolisthesis, congenital Both 0 5 15 congenital anomalies mediumspringgreen 5, 0 2 1 1 1 PRS_PLINK_1e.05 755 Congenital anomalies of limbs Both 1 14 15 congenital anomalies mediumspringgreen 14, 1 4, 1 3, 0 3, 0 4, 0 -0.399 1.28 0.755 0.122 0.671 0.0242 8.4 -3.15 6200 1 0 0.0431 1.47e-08 1.31e+08 -0.134 150 0.999 0 0.874 0.0777 4300 -0.684 282 0.998 0.001 0.505 0.216 0.396 PRS_PLINK_1e.05 755.1 Congenital deformities of feet Both 1 9 15 congenital anomalies mediumspringgreen 9, 1 3, 1 2, 0 2, 0 2, 0 -3.19e-15 2.83 1 0 1 0.0165 77.4 0.68 9140 1 0 1.97 0.00108 1120 0.0542 3530 1 0 1.06 0.141 8.88 -0.32 3210000 1 0 0.726 0.0408 10.1 PRS_PLINK_1e.05 755.6 Other congenital anomalies of lower limb, including pelvic girdle Both 0 4 15 congenital anomalies mediumspringgreen 4, 0 1 1 1 1 PRS_PLINK_1e.05 755.61 Congenital hip dysplasia and deformity Both 0 2 15 congenital anomalies mediumspringgreen 2, 0 1 1 1 1 PRS_PLINK_1e.05 756 Other congenital musculoskeletal anomalies Both 2 17 15 congenital anomalies mediumspringgreen 17, 2 4, 0 4, 0 4, 1 4, 1 0.196 0.718 0.785 0.105 1.22 0.168 7.13 0.0658 61.8 0.999 0 1.07 0.794 1.92 -0.0122 35.7 1 0 0.988 0.0126 28.6 PRS_PLINK_1e.05 756.2 Pectus and other congenital anomalies of ribs/sternum Both 0 1 15 congenital anomalies mediumspringgreen 1, 0 PRS_PLINK_1e.05 756.3 Congenital anomalies of muscle, tendon, fascia, and connective tissue Both 0 2 15 congenital anomalies mediumspringgreen 2, 0 1 1 1 1 PRS_PLINK_1e.05 756.5 Congenital osteodystrophies Both 1 11 15 congenital anomalies mediumspringgreen 11, 1 3, 0 3, 0 2, 0 3, 1 0.062 1.14 0.957 0.019 1.06 0.177 71.3 0.165 456 1 0 1.18 0.317 6.93 PRS_PLINK_1e.05 757 Congenital anomalies of the integument Both 1 4 15 congenital anomalies mediumspringgreen 4, 1 1, 1 1, 0 1, 0 1, 0 2.32e-05 4660 1 0 1 1.54e-07 3.14e+08 0.00117 119 1 0 1 0.993 1.02 15.7 1.03e+09 1 0 6760000 1.59e-11 6.28e+30 0.00641 52.7 1 0 1.01 0.933 1.14 PRS_PLINK_1e.05 758 Chromosomal anomalies and genetic disorders Both 1 2 15 congenital anomalies mediumspringgreen 2, 1 1, 0 1, 1 1, 0 1, 1 -0.103 6730 1 0 0.902 0.394 1.43 -0.204 14000 1 0 0.815 0.515 2 PRS_PLINK_1e.05 758.1 Chromosomal anomalies Both 1 0 15 congenital anomalies mediumspringgreen 0, 1 PRS_PLINK_1e.05 759 Other and unspecified congenital anomalies Both 0 3 15 congenital anomalies mediumspringgreen 3, 0 1 1 1 1 PRS_PLINK_1e.05 760 Back pain Both 25 39 17 symptoms purple 39, 25 9, 6 10, 6 9, 4 10, 9 0.252 0.298 0.397 0.401 1.29 0.757 2.29 0.336 0.973 0.729 0.137 1.4 0.243 8.91 0.509 1.11 0.648 0.189 1.66 0.253 13.9 1.05 1.04 0.314 0.503 2.87 0.495 33.2 PRS_PLINK_1e.05 761 Cervicalgia Both 15 48 17 symptoms purple 48, 15 11, 4 12, 4 12, 4 12, 3 0.113 0.345 0.744 0.129 1.12 0.589 2.22 -1.23 1.37 0.369 0.433 0.291 0.00108 3.63 -0.944 1.36 0.486 0.313 0.389 0.00769 5.36 0.148 1.11 0.894 0.049 1.16 0.156 9.65 PRS_PLINK_1e.05 763 Thoracic or lumbosacral neuritis or radiculitis, unspecified Both 2 39 17 symptoms purple 39, 2 10, 0 10, 0 9, 1 10, 1 0.54 0.656 0.411 0.386 1.72 0.45 13.5 0.291 1.33 0.827 0.083 1.34 0.0619 34.5 -0.0465 1.66 0.978 0.01 0.955 0.00271 65.5 PRS_PLINK_1e.05 764 Sciatica Both 2 38 17 symptoms purple 38, 2 10, 0 9, 0 9, 0 10, 2 0.496 0.642 0.44 0.356 1.64 0.387 15.7 0.526 1.54 0.732 0.135 1.69 0.0751 1180000 PRS_PLINK_1e.05 765 Cervical radiculitis Both 3 25 17 symptoms purple 25, 3 7, 1 6, 2 6, 0 6, 0 -0.276 0.653 0.672 0.173 0.759 0.039 2.97 2.31 2.28 0.311 0.508 10.1 0.209 11800 -0.0426 1.7 0.98 0.009 0.958 0.0483 85.4 0.154 1.64 0.925 0.034 1.17 0.0242 42.2 PRS_PLINK_1e.05 766 Neuralgia, neuritis, and radiculitis NOS Both 6 48 17 symptoms purple 48, 6 12, 1 12, 2 12, 1 12, 2 -0.0777 0.414 0.851 0.07 0.925 0.38 2.12 1.62 1.73 0.349 0.457 5.07 0.276 35100 0.498 1.25 0.69 0.161 1.65 0.0901 101 0.576 1.28 0.653 0.185 1.78 0.172 31.9 PRS_PLINK_1e.05 767 Cervicocranial/Cervicobrachial syndrome Both 0 1 17 symptoms purple 1, 0 PRS_PLINK_1e.05 769 Nonallopathic lesions NEC Both 2 20 17 symptoms purple 20, 2 5, 1 5, 0 5, 0 5, 1 -0.0457 0.786 0.954 0.021 0.955 0.102 6.34 -0.448 33.8 0.989 0.005 0.639 3.68e-09 87500000 -0.289 2.01 0.886 0.053 0.749 0.0154 19.1 0.0818 2.3 0.972 0.012 1.09 0.0391 338 PRS_PLINK_1e.05 770 Myalgia and myositis unspecified Both 11 47 17 symptoms purple 47, 11 11, 1 12, 1 11, 4 12, 5 0.425 0.438 0.332 0.478 1.53 0.66 4 0.505 1.43 0.724 0.14 1.66 0.0865 425 -1.31 1.82 0.473 0.325 0.271 0.000415 13.2 1.16 1.44 0.42 0.376 3.18 0.156 237 PRS_PLINK_1e.05 771 Musculoskeletal symptoms referable to limbs Both 6 44 17 symptoms purple 44, 6 11, 1 11, 1 11, 2 11, 2 -0.15 0.601 0.802 0.096 0.86 0.182 3.14 -1.12 1.68 0.504 0.298 0.325 0.00104 10.7 -0.45 1.47 0.76 0.119 0.638 0.0035 32.3 -1.69 1.8 0.348 0.458 0.185 0.00166 4.72 PRS_PLINK_1e.05 771.1 Swelling of limb Both 11 43 17 symptoms purple 43, 11 11, 4 11, 1 10, 5 11, 1 -0.194 0.373 0.603 0.22 0.823 0.401 1.64 -3.16 1.91 0.0979 1.009 0.0425 0.000166 1.2 0.488 0.916 0.594 0.226 1.63 0.32 9.4 -3.94 2.5 0.115 0.938 0.0194 5.52e-08 1.18 PRS_PLINK_1e.05 771.2 Cramp of limb Both 1 18 17 symptoms purple 18, 1 5, 1 4, 0 4, 0 5, 0 -0.166 1.29 0.898 0.047 0.847 0.0261 66.8 -2.2 40.2 0.956 0.019 0.111 1.22e-10 79700000 -2.97 201 0.988 0.005 0.0514 0.0427 0.0617 3.67 8.91 0.681 0.167 39.2 0.00014 2.95e+08 PRS_PLINK_1e.05 772 Symptoms of the muscles Both 6 23 17 symptoms purple 23, 6 6, 1 6, 1 5, 1 6, 3 0.723 0.892 0.418 0.379 2.06 0.379 19.1 -0.776 2.31 0.737 0.132 0.46 0.00204 26.6 0.607 2.85 0.832 0.08 1.84 0.0164 788 4.34 4.12 0.292 0.535 76.4 0.0394 226000 PRS_PLINK_1e.05 772.1 Muscular wasting and disuse atrophy Both 1 9 17 symptoms purple 9, 1 3, 1 2, 0 2, 0 2, 0 0.44 3.24 0.892 0.05 1.55 0.0176 263 0.209 2730 1 0 1.23 0.507 3.74 0.36 482 0.999 0 1.43 0.00395 695 0.359 789 1 0 1.43 0.578 8.45 PRS_PLINK_1e.05 772.2 Spasm of muscle Both 3 31 17 symptoms purple 31, 3 7, 0 8, 0 7, 2 8, 1 0.623 0.703 0.376 0.425 1.86 0.43 57.5 1.97 2.6 0.449 0.348 7.18 0.000151 15300 0.125 1.5 0.934 0.03 1.13 0.078 123 PRS_PLINK_1e.05 772.3 Muscle weakness Both 4 27 17 symptoms purple 27, 4 7, 1 7, 1 6, 1 7, 1 0.311 0.82 0.705 0.152 1.36 0.229 31.6 -1.07 3.33 0.748 0.126 0.343 6.07e-05 656 -2.01 4.9 0.681 0.167 0.133 1.69e-05 25400 -0.44 1.9 0.817 0.088 0.644 0.00822 162 PRS_PLINK_1e.05 772.4 Rhabdomyolysis Both 2 0 17 symptoms purple 0, 2 PRS_PLINK_1e.05 772.6 Facial weakness Both 0 3 17 symptoms purple 3, 0 1 1 1 1 PRS_PLINK_1e.05 780 Hypothermia/Chills Both 1 8 17 symptoms purple 8, 1 2, 0 2, 0 2, 0 2, 1 0.845 3.77 0.823 0.085 2.33 2.3 4.75 0.177 3540 1 0 1.19 0.709 1.58 PRS_PLINK_1e.05 781 Symptoms involving nervous and musculoskeletal systems Both 4 31 17 symptoms purple 31, 4 8, 0 8, 1 7, 1 8, 2 0.563 0.809 0.487 0.313 1.76 0.37 38.3 0.158 1.65 0.924 0.035 1.17 0.00596 137 -0.23 1.99 0.908 0.042 0.794 0.0213 84 0.679 1.43 0.635 0.198 1.97 0.119 119 PRS_PLINK_1e.05 782.3 Edema Both 12 40 17 symptoms purple 40, 12 10, 4 10, 4 10, 2 10, 2 -0.372 0.4 0.352 0.453 0.689 0.305 1.43 0.223 1.11 0.841 0.075 1.25 0.176 10.8 -0.14 1.08 0.896 0.048 0.869 0.073 6.73 -0.783 1.27 0.537 0.27 0.457 0.0284 4.75 PRS_PLINK_1e.05 782.6 Pallor and flushing Both 2 10 17 symptoms purple 10, 2 3, 0 2, 1 2, 1 3, 0 -0.34 1.63 0.835 0.078 0.712 0.0138 27.2 -0.0599 289 1 0 0.942 0.0265 9.05 -0.0473 476 1 0 0.954 0.631 1.15 PRS_PLINK_1e.05 783 Fever of unknown origin Both 10 52 17 symptoms purple 52, 10 12, 1 13, 4 13, 2 13, 3 0.313 0.371 0.398 0.4 1.37 0.695 3 1.34 1.33 0.315 0.501 3.81 0.382 336 0.459 1.3 0.724 0.14 1.58 0.083 233000 2.12 1.95 0.276 0.559 8.34 0.349 224000 PRS_PLINK_1e.05 785 Abdominal pain Both 30 34 17 symptoms purple 34, 30 9, 4 8, 12 8, 7 9, 6 -0.0238 0.297 0.936 0.029 0.976 0.559 1.69 0.983 0.849 0.247 0.607 2.67 0.633 13.1 0.329 1.03 0.749 0.126 1.39 0.198 8.48 -0.644 1.15 0.576 0.239 0.525 0.0531 3.7 PRS_PLINK_1e.05 788 Syncope and collapse Both 5 49 17 symptoms purple 49, 5 13, 0 12, 2 12, 2 12, 1 0.471 0.53 0.374 0.427 1.6 0.602 10.1 1.89 1.66 0.256 0.593 6.62 0.394 23000 0.749 1.27 0.556 0.255 2.12 0.109 165 0.562 1.43 0.693 0.159 1.75 0.118 66 PRS_PLINK_1e.05 789 Nausea and vomiting Both 18 46 17 symptoms purple 46, 18 11, 5 11, 3 11, 4 12, 6 0.0992 0.305 0.745 0.128 1.1 0.631 1.98 -0.314 1.01 0.756 0.121 0.731 0.119 4.31 0.174 0.907 0.848 0.072 1.19 0.233 6.24 -0.555 1.04 0.593 0.227 0.574 0.0748 3.49 PRS_PLINK_1e.05 789.1 Persistent vomiting Both 2 10 17 symptoms purple 10, 2 3, 0 2, 0 2, 0 3, 2 1.73 1.95 0.374 0.427 5.65 0.364 1260 0.144 383 1 0 1.15 0.345 1.01 PRS_PLINK_1e.05 790 Nonspecific findings on examination of blood Both 16 27 17 symptoms purple 27, 16 7, 4 7, 2 6, 5 7, 5 -0.288 0.588 0.624 0.205 0.749 0.0173 2.39 -0.969 1.52 0.524 0.281 0.379 0.00166 30.1 -0.8 2.3 0.728 0.138 0.449 5.67e-06 671 -1.15 1.6 0.475 0.324 0.318 0.00469 7.84 PRS_PLINK_1e.05 790.1 Elevated sedimentation rate Both 1 4 17 symptoms purple 4, 1 1, 0 1, 1 1, 0 1, 0 0.0969 3150 1 0 1.1 0.66 3.8 -0.0228 134 1 0 0.977 0.823 1.55 PRS_PLINK_1e.05 790.6 Other abnormal blood chemistry Both 22 40 17 symptoms purple 40, 22 9, 6 10, 3 10, 8 10, 5 0.201 0.352 0.568 0.246 1.22 0.645 2.45 -1.87 1.5 0.214 0.67 0.155 2.52e-06 2.15 0.114 0.952 0.904 0.044 1.12 0.198 7.72 -0.803 1.36 0.555 0.256 0.448 0.0129 5.06 PRS_PLINK_1e.05 790.8 Elevated C-reactive protein (CRP) Both 0 5 17 symptoms purple 5, 0 2 1 1 1 PRS_PLINK_1e.05 790.9 Abnormal arterial blood gases Both 0 2 17 symptoms purple 2, 0 1 1 1 1 PRS_PLINK_1e.05 791 Gangrene Both 0 13 17 symptoms purple 13, 0 4 3 3 3 PRS_PLINK_1e.05 792 Abnormal Papanicolaou smear of cervix and cervical HPV Female 6 15 11 genitourinary black 15, 6 4, 4 4, 0 3, 0 4, 2 -0.946 0.851 0.267 0.574 0.388 0.0714 1.48 -2.29 4.8 0.634 0.198 0.101 3.74e-06 338 2.44 9.86 0.805 0.094 11.4 8.65 14.2 -5.32 4.34 0.22 0.658 0.0049 1.3e-17 1.6 PRS_PLINK_1e.05 792.1 Papanicolaou smear of cervix or vagina with atypical squamous cells Female 4 7 11 genitourinary black 7, 4 2, 3 2, 0 1, 1 2, 0 4.96 35.5 0.889 0.051 142 101 196 0.339 4490 1 0 1.4 0.318 6.22 0.241 1770 1 0 1.27 0.254 7.88 0.667 1340 1 0 1.95 0.276 25.9 PRS_PLINK_1e.05 794 Abnormal results of other function studies (bladder, pancreas, placenta, spleen, etc) Both 0 5 17 symptoms purple 5, 0 2 1 1 1 PRS_PLINK_1e.05 795 Other and nonspecific abnormal cytological, histological and immunological findings Both 3 27 17 symptoms purple 27, 3 7, 1 7, 0 6, 0 7, 2 0.0681 0.695 0.922 0.035 1.07 0.265 6.55 -0.548 3.41 0.872 0.059 0.578 4.65e-05 4410000 -0.565 1.95 0.773 0.112 0.569 0.00152 15.2 -0.829 2.87 0.773 0.112 0.437 0.000189 129 PRS_PLINK_1e.05 795.8 Abnormal tumor markers Both 1 13 17 symptoms purple 13, 1 4, 0 3, 0 3, 0 3, 1 -0.0947 1.4 0.946 0.024 0.91 0.0333 252 -0.411 27.7 0.988 0.005 0.663 0.0457 0.618 PRS_PLINK_1e.05 795.81 Elevated carcinoembryonic antigen [CEA] Both 0 1 17 symptoms purple 1, 0 PRS_PLINK_1e.05 795.82 Elevated cancer antigen 125 [CA 125] Both 0 2 17 symptoms purple 2, 0 1 1 1 1 PRS_PLINK_1e.05 796 Elevated prostate specific antigen [PSA] Male 2 10 11 genitourinary black 10, 2 3, 0 2, 0 2, 1 3, 1 -0.301 0.972 0.757 0.121 0.74 0.146 7.49 -0.0391 3950 1 0 0.962 0.206 3.96 -0.0471 127 1 0 0.954 0.831 0.983 PRS_PLINK_1e.05 797 Shock Both 0 10 17 symptoms purple 10, 0 3 2 2 3 PRS_PLINK_1e.05 797.1 Cardiogenic shock Both 0 4 17 symptoms purple 4, 0 1 1 1 1 PRS_PLINK_1e.05 798 Malaise and fatigue Both 25 39 17 symptoms purple 39, 25 9, 4 10, 7 9, 9 10, 5 0.15 0.324 0.644 0.191 1.16 0.644 2.19 0.407 0.934 0.663 0.179 1.5 0.301 8.47 0.239 0.961 0.803 0.095 1.27 0.211 7.43 0.253 1.13 0.822 0.085 1.29 0.188 10.9 PRS_PLINK_1e.05 798.1 Chronic fatigue syndrome Both 4 20 17 symptoms purple 20, 4 5, 1 5, 0 5, 1 5, 2 1.12 1.06 0.292 0.534 3.06 0.501 612 -0.552 2.88 0.848 0.072 0.576 0.00553 411 1.29 3.08 0.674 0.171 3.65 0.0283 884 -1.64 4.59 0.722 0.142 0.195 4.97e-08 1130000 PRS_PLINK_1e.05 800 Fracture of lower limb Both 6 28 18 injuries & poisonings gray50 28, 6 6, 1 7, 1 7, 2 7, 2 0.123 0.496 0.804 0.095 1.13 0.457 3.3 0.414 1.72 0.809 0.092 1.51 0.00822 380 -0.119 1.41 0.933 0.03 0.888 0.0487 16.8 2.43 2.43 0.316 0.5 11.4 0.291 135000 PRS_PLINK_1e.05 800.1 Fracture of neck of femur Both 0 7 18 injuries & poisonings gray50 7, 0 2 2 1 2 PRS_PLINK_1e.05 800.2 Fracture of unspecified part of femur Both 2 3 18 injuries & poisonings gray50 3, 2 1, 2 1, 0 1, 0 1, 2 0.0197 446 1 0 1.02 0.596 1.65 -0.563 5660 1 0 0.57 0.0464 1.85 -0.983 4830 1 0 0.374 0.356 1.1 PRS_PLINK_1e.05 800.3 Fracture of tibia and fibula Both 4 15 18 injuries & poisonings gray50 15, 4 3, 0 4, 0 3, 1 4, 3 0.5 0.825 0.545 0.264 1.65 0.475 318 -0.0846 1580 1 0 0.919 0.173 9.23 1.09 63 0.986 0.006 2.98 0.00478 1870 PRS_PLINK_1e.05 800.4 Fracture of patella Both 2 3 18 injuries & poisonings gray50 3, 2 1, 1 1, 0 1, 1 1, 1 -0.0408 343 1 0 0.96 0.708 1.11 0.00102 19.7 1 0 1 0.982 1.02 -0.112 1460 1 0 0.894 0.34 1.46 PRS_PLINK_1e.05 801 Fracture of ankle and foot Both 7 36 18 injuries & poisonings gray50 36, 7 8, 2 9, 2 9, 1 9, 2 0.105 0.422 0.804 0.095 1.11 0.519 2.53 -0.487 2.01 0.808 0.092 0.614 0.000211 46 -0.0611 1.72 0.972 0.012 0.941 0.0244 90200 0.569 1.31 0.665 0.177 1.77 0.193 35.3 PRS_PLINK_1e.05 801.1 Fracture of foot Both 2 14 18 injuries & poisonings gray50 14, 2 3, 0 3, 0 3, 1 4, 1 0.217 0.938 0.817 0.088 1.24 0.283 7.64 -0.105 718 1 0 0.901 0.204 3.29 2.19 11.3 0.845 0.073 8.96 10 7.77 PRS_PLINK_1e.05 802 Fracture of pelvis Both 0 5 18 injuries & poisonings gray50 5, 0 2 1 1 1 PRS_PLINK_1e.05 803 Fracture of upper limb Both 6 23 18 injuries & poisonings gray50 23, 6 5, 2 6, 3 5, 0 6, 1 -0.312 0.59 0.597 0.224 0.732 0.125 2.1 1.51 1.96 0.441 0.355 4.52 0.178 84800 0.238 1.8 0.894 0.048 1.27 0.00946 58.6 -2.71 4.22 0.52 0.284 0.0663 3.48e-07 69.3 PRS_PLINK_1e.05 803.1 Fracture of humerus Both 2 6 18 injuries & poisonings gray50 6, 2 2, 0 1, 0 1, 1 2, 1 0.0624 301 1 0 1.06 0.128 3.17 -5 42000 1 0 0.00674 2.03e-25 2.58e+19 -0.381 1780 1 0 0.683 0.646 1.48 PRS_PLINK_1e.05 803.2 Fracture of radius and ulna Both 4 14 18 injuries & poisonings gray50 14, 4 4, 2 3, 1 3, 0 4, 1 -0.769 0.988 0.436 0.36 0.463 0.0909 2.47 0.351 21.8 0.987 0.006 1.42 1.23 15500 -4.84 22.5 0.83 0.081 0.00791 3.35e-08 0.00963 -1.44 3.24 0.656 0.183 0.236 0.00225 138 PRS_PLINK_1e.05 803.21 Colles' fracture Both 0 4 18 injuries & poisonings gray50 4, 0 1 1 1 1 PRS_PLINK_1e.05 803.3 Fracture of clavicle or scapula Both 0 2 18 injuries & poisonings gray50 2, 0 1 1 1 1 PRS_PLINK_1e.05 804 Fracture of hand or wrist Both 8 26 18 injuries & poisonings gray50 26, 8 6, 4 6, 1 6, 3 7, 0 0.236 0.555 0.671 0.174 1.27 0.51 5 -0.644 2.05 0.753 0.123 0.525 0.00805 48.3 1.72 1.72 0.317 0.499 5.59 0.413 132000 -0.439 1.86 0.813 0.09 0.645 0.0137 139 PRS_PLINK_1e.05 805 Fracture of vertebral column without mention of spinal cord injury Both 2 8 18 injuries & poisonings gray50 8, 2 2, 0 2, 0 2, 1 2, 1 2.87 7.65 0.707 0.15 17.7 0.000917 16200000 -0.00455 34.3 1 0 0.995 0.713 1.23 -0.114 4390 1 0 0.892 0.147 3.17 PRS_PLINK_1e.05 807 Fracture of ribs Both 2 8 18 injuries & poisonings gray50 8, 2 2, 1 2, 0 2, 0 2, 1 -0.371 2.11 0.861 0.065 0.69 0.0869 5.24 -0.00494 344 1 0 0.995 0.776 1.18 0.0368 1330 1 0 1.04 0.501 2.22 -0.0116 1670 1 0 0.988 0.611 1.55 PRS_PLINK_1e.05 809 Fracture of unspecified bones Both 6 37 18 injuries & poisonings gray50 37, 6 9, 3 9, 2 9, 0 9, 1 -1.49 0.908 0.101 0.997 0.225 0.0071 1.16 -0.0302 1.46 0.983 0.007 0.97 0.00115 151 -1.09 2.23 0.627 0.203 0.338 0.000411 37 -1.66 2.33 0.477 0.321 0.191 3.12e-05 10.8 PRS_PLINK_1e.05 816 Cerebral laceration and contusion Both 0 3 18 injuries & poisonings gray50 3, 0 1 1 1 1 PRS_PLINK_1e.05 817 Concussion Both 2 22 18 injuries & poisonings gray50 22, 2 5, 0 5, 0 5, 1 6, 1 0.144 0.776 0.853 0.069 1.15 0.157 2050 -1.63 55.2 0.976 0.01 0.196 6.01e-15 6.82e+12 -0.161 7.41 0.983 0.008 0.852 7.47e-06 107000 PRS_PLINK_1e.05 818 Intracranial hemorrhage (injury) Both 0 5 18 injuries & poisonings gray50 5, 0 2 1 1 1 PRS_PLINK_1e.05 818.1 Subdural hemorrhage (injury) Both 0 1 18 injuries & poisonings gray50 1, 0 PRS_PLINK_1e.05 818.2 Subarachnoid hemorrhage (injury) Both 0 4 18 injuries & poisonings gray50 4, 0 1 1 1 1 PRS_PLINK_1e.05 819 Skull and face fracture and other intercranial injury Both 4 37 18 injuries & poisonings gray50 37, 4 9, 1 9, 0 9, 0 9, 3 -0.72 0.686 0.294 0.532 0.487 0.0463 2.13 -0.125 1.92 0.948 0.023 0.883 0.00386 2310 -0.0712 1.53 0.963 0.016 0.931 0.00557 27.3 0.12 1.88 0.949 0.023 1.13 0.000773 3830 PRS_PLINK_1e.05 830 Dislocation Both 12 42 18 injuries & poisonings gray50 42, 12 10, 7 10, 1 10, 3 11, 1 -0.224 0.372 0.547 0.262 0.799 0.391 1.59 -0.575 1.15 0.619 0.209 0.563 0.0498 4.47 -0.476 1.03 0.643 0.192 0.621 0.0893 3.95 -1.79 1.36 0.186 0.729 0.166 0.00513 1.73 PRS_PLINK_1e.05 835 Internal derangement of knee Both 5 27 18 injuries & poisonings gray50 27, 5 6, 2 7, 1 6, 1 7, 1 0.0992 0.52 0.849 0.071 1.1 0.433 3.22 0.606 2.78 0.828 0.082 1.83 0.000328 7860 -2.34 3.54 0.508 0.294 0.096 3.84e-05 57.6 -0.718 1.7 0.673 0.172 0.488 0.00302 9.1 PRS_PLINK_1e.05 836 Traumatic arthropathy Both 2 6 18 injuries & poisonings gray50 6, 2 2, 2 1, 0 1, 0 2, 0 -0.289 45600 1 0 0.749 0.00151 513 0.185 1660 1 0 1.2 0.643 3.18 -0.249 5380 1 0 0.779 0.0301 2.15 -0.0416 504 1 0 0.959 1.51e-06 1.76e+08 PRS_PLINK_1e.05 840 Sprains and strains Both 19 43 18 injuries & poisonings gray50 43, 19 10, 6 11, 8 10, 3 11, 2 -0.173 0.308 0.575 0.241 0.841 0.473 1.48 0.0778 0.874 0.929 0.032 1.08 0.224 5.08 0.117 0.97 0.904 0.044 1.12 0.21 7.51 -1.31 1.21 0.282 0.55 0.271 0.0167 2.11 PRS_PLINK_1e.05 840.1 Muscle/tendon sprain Both 2 3 18 injuries & poisonings gray50 3, 2 1, 2 1, 0 1, 0 1, 2 10.3 1.52e+08 1 0 29400 7.18e-09 5.45e+11 0.109 1530 1 0 1.12 0.782 1.21 -0.161 2040 1 0 0.851 0.247 1.46 PRS_PLINK_1e.05 840.2 Rotator cuff (capsule) sprain Both 7 16 18 injuries & poisonings gray50 16, 7 4, 3 4, 2 4, 2 4, 0 -0.0544 0.653 0.934 0.03 0.947 0.306 2.91 -0.286 5.2 0.956 0.019 0.751 0.00112 86.8 0.307 2.8 0.913 0.04 1.36 0.00032 190 -0.0362 3.56 0.992 0.004 0.964 0.00376 280 PRS_PLINK_1e.05 840.3 Joint/ligament sprain Both 6 40 18 injuries & poisonings gray50 40, 6 9, 3 10, 2 10, 1 10, 0 -0.487 0.438 0.266 0.576 0.614 0.199 1.34 -3.94 2.79 0.158 0.8 0.0195 1.71e-07 2 -0.975 1.33 0.463 0.335 0.377 0.0222 3.69 -1.97 1.58 0.212 0.674 0.139 0.000392 2 PRS_PLINK_1e.05 841 Sprains and strains of back and neck Both 1 26 18 injuries & poisonings gray50 26, 1 6, 1 6, 0 6, 0 7, 0 0.0564 0.611 0.926 0.033 1.06 0.259 8.65 -0.383 1.65 0.816 0.088 0.682 0.0124 11.5 -0.689 2.37 0.771 0.113 0.502 0.0104 1760 -0.26 1.66 0.876 0.058 0.771 0.0219 28.1 PRS_PLINK_1e.05 842 Other sprains and strains Both 4 23 18 injuries & poisonings gray50 23, 4 5, 3 6, 0 5, 0 6, 1 -0.519 0.639 0.417 0.38 0.595 0.113 2.18 -1.91 1.91 0.316 0.501 0.148 0.000205 2.25 -1.94 4.85 0.689 0.161 0.144 9.93e-09 62400 -1.34 2.38 0.575 0.241 0.262 0.00145 10.1 PRS_PLINK_1e.05 850 Hemorrhage or hematoma complicating a procedure Both 2 24 18 injuries & poisonings gray50 24, 2 6, 0 6, 1 6, 0 6, 1 0.967 0.968 0.318 0.498 2.63 0.159 42.2 0.768 1.86 0.68 0.167 2.15 0.0615 201 0.798 2.36 0.736 0.133 2.22 0.0231 341 PRS_PLINK_1e.05 851 Complications of transplants and reattached limbs Both 2 34 18 injuries & poisonings gray50 34, 2 9, 0 8, 0 8, 1 9, 1 0.019 0.607 0.975 0.011 1.02 0.154 5.89 0.627 1.53 0.682 0.166 1.87 0.0615 137 0.318 1.65 0.847 0.072 1.37 7.63e-05 36000 PRS_PLINK_1e.05 853 Complication of colostomy or enterostomy Both 0 3 18 injuries & poisonings gray50 3, 0 1 1 1 1 PRS_PLINK_1e.05 854 Complications of cardiac/vascular device, implant, and graft Both 4 25 18 injuries & poisonings gray50 25, 4 7, 0 6, 0 6, 1 6, 3 0.687 0.613 0.263 0.58 1.99 0.663 20.8 0.142 1.82 0.938 0.028 1.15 0.0305 295 0.731 1.38 0.597 0.224 2.08 0.251 5.02e+10 PRS_PLINK_1e.05 855 Complication of nervous system device, implant, and graft Both 1 2 18 injuries & poisonings gray50 2, 1 1, 0 1, 1 1, 0 1, 1 -0.00867 33.3 1 0 0.991 0.911 1.03 0.00273 35 1 0 1 0.926 1.01 PRS_PLINK_1e.05 856 Vascular complications of surgery and medical procedures Both 0 2 18 injuries & poisonings gray50 2, 0 1 1 1 1 PRS_PLINK_1e.05 857 Mechanical complication of unspecified genitourinary device, implant, and graft Both 4 20 18 injuries & poisonings gray50 20, 4 5, 0 5, 2 5, 0 5, 2 0.555 0.69 0.422 0.375 1.74 0.517 13.9 1.52 1.86 0.412 0.385 4.59 0.332 133 -1.2 3.21 0.709 0.149 0.302 8.66e-05 35.6 PRS_PLINK_1e.05 858 Complication of internal orthopedic device Both 2 23 18 injuries & poisonings gray50 23, 2 5, 1 6, 0 5, 1 6, 0 -0.114 0.554 0.837 0.077 0.892 0.229 2.6 -0.958 2.29 0.676 0.17 0.384 0.00114 28.2 -1.69 3.2 0.597 0.224 0.184 5.21e-05 256 -1.03 2.13 0.63 0.201 0.358 0.0126 15.2 PRS_PLINK_1e.05 859 Complication due to other implant and internal device Both 1 21 18 injuries & poisonings gray50 21, 1 6, 0 5, 0 5, 0 5, 1 0.512 0.931 0.582 0.235 1.67 0.2 41.5 0.138 2.66 0.958 0.018 1.15 0.0145 243 PRS_PLINK_1e.05 860 Bone marrow or stem cell transplant Both 0 3 2 neoplasms darkcyan 3, 0 1 1 1 1 PRS_PLINK_1e.05 870 Open wounds of head; neck; and trunk Both 5 48 18 injuries & poisonings gray50 48, 5 12, 2 12, 1 12, 1 12, 0 -0.446 0.408 0.274 0.562 0.64 0.248 1.36 -0.25 1.14 0.826 0.083 0.779 0.0651 6.83 -0.111 1.08 0.918 0.037 0.895 0.096 7.16 -0.556 1.4 0.692 0.16 0.573 0.00541 8.18 PRS_PLINK_1e.05 870.1 Open wound or laceration of eye or eyelid Both 0 2 18 injuries & poisonings gray50 2, 0 1 1 1 1 PRS_PLINK_1e.05 870.2 Open wound of ear Both 0 3 18 injuries & poisonings gray50 3, 0 1 1 1 1 PRS_PLINK_1e.05 870.3 Other open wound of head and face Both 1 13 18 injuries & poisonings gray50 13, 1 4, 1 3, 0 3, 0 3, 0 0.53 3.1 0.864 0.063 1.7 0.00064 355 0.433 2530 1 0 1.54 0.558 6.66 -1.88 40.8 0.963 0.016 0.152 0.0152 0.443 -1.62 140 0.991 0.004 0.197 0.0646 0.382 PRS_PLINK_1e.05 870.4 Open wound of nose and sinus Both 1 2 18 injuries & poisonings gray50 2, 1 1, 1 1, 0 1, 1 1, 0 0.00385 23.3 1 0 1 0.982 1.02 -0.00168 15.4 1 0 0.998 0.964 1.07 PRS_PLINK_1e.05 870.5 Open wound of lip and mouth Both 0 7 18 injuries & poisonings gray50 7, 0 2 2 1 2 PRS_PLINK_1e.05 870.6 Open wound of neck Both 0 1 18 injuries & poisonings gray50 1, 0 PRS_PLINK_1e.05 870.8 Open wound of genital organs Both 1 1 18 injuries & poisonings gray50 1, 1 -0.00183 372 1 0 0.998 0.954 1.05 PRS_PLINK_1e.05 871 Open wounds of extremities Both 7 49 18 injuries & poisonings gray50 49, 7 13, 1 12, 3 12, 2 12, 1 0.676 0.686 0.325 0.489 1.97 0.505 18.4 1.2 1.4 0.39 0.409 3.33 0.283 1e+05 1.12 1.41 0.426 0.371 3.07 0.151 6150 0.197 1.61 0.903 0.044 1.22 6.94e-05 4590 PRS_PLINK_1e.05 871.1 Open wound of hand except finger(s) Both 1 13 18 injuries & poisonings gray50 13, 1 4, 0 3, 1 3, 0 3, 0 -0.192 0.986 0.845 0.073 0.825 0.0991 6.45 0.0296 400 1 0 1.03 0.648 1.71 PRS_PLINK_1e.05 871.2 Open wound of finger(s) Both 4 25 18 injuries & poisonings gray50 25, 4 7, 1 6, 1 6, 1 6, 1 0.397 0.942 0.673 0.172 1.49 0.281 46.1 0.404 1.6 0.801 0.096 1.5 0.0273 174 -0.297 2.43 0.903 0.045 0.743 0.0157 300 0.343 2.68 0.898 0.047 1.41 0.00427 1880 PRS_PLINK_1e.05 871.3 Open wound of foot except toe(s) alone Both 1 12 18 injuries & poisonings gray50 12, 1 3, 0 3, 1 3, 0 3, 0 0.369 2.16 0.864 0.063 1.45 0.000229 66.5 0.00354 46.4 1 0 1 0.198 8.84 PRS_PLINK_1e.05 871.4 Open wound of toe(s) Both 2 9 18 injuries & poisonings gray50 9, 2 3, 1 2, 0 2, 1 2, 0 0.071 4.18 0.986 0.006 1.07 0.00189 783 0.15 2.7e+07 1 0 1.16 0.287 5.02 0.421 3540 1 0 1.52 0.412 4.43 -0.0917 6960 1 0 0.912 0.0114 1.99 PRS_PLINK_1e.05 872 Traumatic amputation Both 1 15 18 injuries & poisonings gray50 15, 1 4, 0 4, 1 3, 0 4, 0 -0.389 1.13 0.73 0.137 0.677 0.0647 14 2.33 14700000 1 0 10.3 0.00404 47700 PRS_PLINK_1e.05 874 Complication of amputation stump Both 0 3 18 injuries & poisonings gray50 3, 0 1 1 1 1 PRS_PLINK_1e.05 875 Non-healing surgical wound Both 0 4 18 injuries & poisonings gray50 4, 0 1 1 1 1 PRS_PLINK_1e.05 876 Posttraumatic wound infection not elsewhere classified Both 0 9 18 injuries & poisonings gray50 9, 0 3 2 2 2 PRS_PLINK_1e.05 907 Injuries to the nervous system Both 2 16 18 injuries & poisonings gray50 16, 2 4, 0 4, 1 4, 0 4, 1 0.492 0.727 0.498 0.303 1.64 0.466 16 1.58 25.6 0.951 0.022 4.83 1.04 19.6 0.611 7.07 0.931 0.031 1.84 1.78 2.45 PRS_PLINK_1e.05 910 Superficial injury, infected Both 0 3 18 injuries & poisonings gray50 3, 0 1 1 1 1 PRS_PLINK_1e.05 911 Blister Both 5 8 18 injuries & poisonings gray50 8, 5 2, 3 2, 2 2, 0 2, 0 0.141 1.84 0.939 0.027 1.15 0.0104 21.9 0.495 524 0.999 0 1.64 0.596 4.77 -0.151 1510 1 0 0.86 0.0231 23.2 -0.042 137 1 0 0.959 0.475 1.62 PRS_PLINK_1e.05 912 Insect bite Both 0 9 18 injuries & poisonings gray50 9, 0 2 2 2 2 PRS_PLINK_1e.05 913 Toxic effect of venom Both 2 6 18 injuries & poisonings gray50 6, 2 2, 1 1, 0 1, 0 2, 1 -0.422 50.8 0.993 0.003 0.656 0.0165 7.93 0.00876 2000 1 0 1.01 0.71 1.47 -0.0239 4150 1 0 0.976 0.377 2.29 1.66 320 0.996 0.002 5.26 0.0172 231 PRS_PLINK_1e.05 916 Contusion Both 8 48 18 injuries & poisonings gray50 48, 8 11, 3 12, 3 12, 1 12, 1 -0.502 0.43 0.243 0.614 0.605 0.239 1.38 0.106 1.12 0.924 0.034 1.11 0.131 10.3 -0.782 1.15 0.495 0.306 0.457 0.0187 3.42 -2.26 2.05 0.271 0.567 0.104 2.19e-06 5.96 PRS_PLINK_1e.05 930 Allergic reaction to food Both 0 10 18 injuries & poisonings gray50 10, 0 3 2 2 3 PRS_PLINK_1e.05 931 Contact dermatitis and other eczema due to plants [except food] Both 1 11 13 dermatologic firebrick 11, 1 3, 0 3, 0 2, 1 3, 0 -0.243 1.19 0.839 0.076 0.784 0.0614 5.96 -6.67 4310 0.999 0.001 0.00127 4.49e-08 9.92e+10 PRS_PLINK_1e.05 938 Dermatitis due to solar radiation Both 8 32 13 dermatologic firebrick 32, 8 8, 4 8, 2 8, 1 8, 1 -0.18 0.464 0.698 0.156 0.835 0.333 1.96 1.31 2.39 0.584 0.234 3.71 0.0321 374000 -0.868 1.33 0.513 0.29 0.42 0.0328 3.87 -0.351 1.39 0.801 0.096 0.704 0.0514 7.41 PRS_PLINK_1e.05 938.1 Acute dermatitis due to solar radiation Both 0 4 13 dermatologic firebrick 4, 0 1 1 1 1 PRS_PLINK_1e.05 938.2 Chronic dermatitis due to solar radiation Both 8 31 13 dermatologic firebrick 31, 8 8, 4 8, 2 7, 0 8, 2 -0.179 0.463 0.699 0.155 0.836 0.334 1.96 1.31 2.39 0.584 0.234 3.71 0.0321 374000 -1.45 1.6 0.366 0.437 0.234 0.00156 3.96 0.0561 1.08 0.959 0.018 1.06 0.164 7.17 PRS_PLINK_1e.05 939 Atopic/contact dermatitis due to other or unspecified Both 12 40 13 dermatologic firebrick 40, 12 9, 2 10, 3 10, 4 10, 3 0.626 0.458 0.172 0.765 1.87 0.834 4.94 1.95 1.98 0.324 0.489 7.03 0.359 5330000 2.01 1.83 0.272 0.565 7.43 0.228 44000 1.85 1.45 0.202 0.695 6.39 0.63 360 PRS_PLINK_1e.05 939.1 Contact and allergic dermatitis of eyelid Both 0 1 13 dermatologic firebrick 1, 0 PRS_PLINK_1e.05 941 Adverse reaction to serum or vaccine Both 0 5 18 injuries & poisonings gray50 5, 0 2 1 1 1 PRS_PLINK_1e.05 942 Infusion and transfusion reaction Both 0 4 18 injuries & poisonings gray50 4, 0 1 1 1 1 PRS_PLINK_1e.05 946 Anaphylactic shock NOS Both 3 5 18 injuries & poisonings gray50 5, 3 2, 0 1, 2 1, 1 1, 0 -0.819 12300000 1 0 0.441 0.00213 13600000 -0.115 2450 1 0 0.891 0.82 1.5 0.034 6800 1 0 1.03 0.319 1.14 PRS_PLINK_1e.05 947 Urticaria Both 5 15 13 dermatologic firebrick 15, 5 4, 3 4, 1 3, 1 4, 0 -1.84 1.52 0.225 0.647 0.158 0.002 1.68 0.0599 9.49 0.995 0.002 1.06 2.44e-07 10200000 -5.18 6.59 0.433 0.364 0.00565 3.88e-08 31.6 -1.05 2.61 0.688 0.162 0.351 0.000795 15.9 PRS_PLINK_1e.05 949 Allergies, other Both 13 40 18 injuries & poisonings gray50 40, 13 9, 5 10, 2 10, 3 10, 3 -0.0249 0.425 0.953 0.021 0.975 0.428 2.34 -1.23 1.2 0.306 0.515 0.293 0.0162 2.07 -0.662 1.21 0.586 0.232 0.516 0.0418 5.48 0.56 1.49 0.707 0.151 1.75 0.115 69.5 PRS_PLINK_1e.05 952 Spinal cord injury without evidence of spinal bone injury Both 1 8 18 injuries & poisonings gray50 8, 1 2, 1 2, 0 2, 0 2, 0 0.11 90.3 0.999 0 1.12 0.462 2.5 -0.0419 4440 1 0 0.959 0.445 1.96 -0.0848 5040 1 0 0.919 0.0848 3.85 -3.31e-05 3260 1 0 1 0.591 1.59 PRS_PLINK_1e.05 957 Injury to other and unspecified nerves Both 1 1 18 injuries & poisonings gray50 1, 1 -0.000387 402 1 0 1 0.994 1.05 PRS_PLINK_1e.05 958 Certain early complications of trauma or procedure Both 0 10 18 injuries & poisonings gray50 10, 0 3 2 2 3 PRS_PLINK_1e.05 958.1 Postoperative shock Both 0 2 18 injuries & poisonings gray50 2, 0 1 1 1 1 PRS_PLINK_1e.05 960 Poisoning by antibiotics Both 5 26 18 injuries & poisonings gray50 26, 5 7, 1 6, 1 6, 0 7, 2 -0.537 0.565 0.342 0.466 0.584 0.165 1.47 0.277 4.35 0.949 0.023 1.32 5.55e-05 1010 -1.02 2.08 0.622 0.206 0.36 0.000197 10.4 -0.0253 2.04 0.99 0.004 0.975 0.00226 711000 PRS_PLINK_1e.05 960.1 Adverse effects of antibacterials (not penicillins) Both 0 3 18 injuries & poisonings gray50 3, 0 1 1 1 1 PRS_PLINK_1e.05 960.2 Allergy/adverse effect of penicillin Both 3 19 18 injuries & poisonings gray50 19, 3 5, 1 5, 0 4, 1 5, 1 -0.66 0.816 0.418 0.379 0.517 0.00819 6.66 0.602 8.74 0.945 0.025 1.83 1.66 1.99 -1.21 3.32 0.714 0.146 0.297 0.000855 44.3 -1.95 4.33 0.653 0.185 0.142 1.27e-06 1020 PRS_PLINK_1e.05 961 Poisoning by other anti-infectives Both 0 9 18 injuries & poisonings gray50 9, 0 3 2 2 2 PRS_PLINK_1e.05 961.1 Poisoning/allergy of sulfonamides Both 2 6 18 injuries & poisonings gray50 6, 2 2, 0 1, 0 1, 1 2, 1 -0.636 136 0.996 0.002 0.529 0.0324 12.5 2.27 114 0.984 0.007 9.69 3.34e-05 3510000 -0.609 24100000 1 0 0.544 0.0011 53.7 PRS_PLINK_1e.05 962 Poisoning by hormones and synthetic substitutes Both 3 16 18 injuries & poisonings gray50 16, 3 4, 1 4, 2 4, 0 4, 0 -0.379 0.748 0.612 0.213 0.685 0.111 7.9 1.39 3.83 0.716 0.145 4.02 0.00207 2670 -0.193 889 1 0 0.824 0.202 1.53 0.588 318 0.999 0.001 1.8 1.67 1.32 PRS_PLINK_1e.05 962.1 Adrenal cortical steroids causing adverse effects in therapeutic use Both 1 8 18 injuries & poisonings gray50 8, 1 2, 0 2, 1 2, 0 2, 0 0.0301 70.4 1 0 1.03 0.00975 97.8 0.296 1250 1 0 1.34 0.558 6.21 PRS_PLINK_1e.05 962.2 Insulins and antidiabetic agents causing adverse effects in therapeutic use Both 1 1 18 injuries & poisonings gray50 1, 1 0.00282 378 1 0 1 0.988 1.01 PRS_PLINK_1e.05 962.3 Hormones and synthetic substitutes causing adverse effects in therapeutic use Both 2 9 18 injuries & poisonings gray50 9, 2 3, 2 2, 0 2, 0 2, 0 -0.79 1.44 0.583 0.234 0.454 0.0372 3.96 -0.0375 140 1 0 0.963 0.889 1.09 -0.0359 218 1 0 0.965 0.487 1.28 -0.776 465 0.999 0.001 0.46 0.0538 2.14 PRS_PLINK_1e.05 963 Poisoning by primarily systemic agents Both 0 25 18 injuries & poisonings gray50 25, 0 7 6 6 6 PRS_PLINK_1e.05 963.1 Antineoplastic and immunosuppressive drugs causing adverse effects Both 0 23 18 injuries & poisonings gray50 23, 0 6 6 5 6 PRS_PLINK_1e.05 964 Poisoning by agents primarily affecting blood constituents Both 0 13 18 injuries & poisonings gray50 13, 0 4 3 3 3 PRS_PLINK_1e.05 964.1 Anticoagulants causing adverse effects Both 0 12 18 injuries & poisonings gray50 12, 0 3 3 3 3 PRS_PLINK_1e.05 965 Poisoning by analgesics, antipyretics, and antirheumatics Both 1 5 18 injuries & poisonings gray50 5, 1 2, 0 1, 0 1, 0 1, 1 -0.033 11900 1 0 0.968 0.269 5.79 0.154 91500 1 0 1.17 1.69e-11 4.58 PRS_PLINK_1e.05 965.1 Opiates and related narcotics causing adverse effects in therapeutic use Both 1 16 18 injuries & poisonings gray50 16, 1 4, 0 4, 0 4, 0 4, 1 0.188 0.78 0.809 0.092 1.21 0.316 5.04 -1.78 92.5 0.985 0.007 0.168 1.88e-07 135000 PRS_PLINK_1e.05 965.3 Salicylates causing adverse effects in therapeutic use Both 0 1 18 injuries & poisonings gray50 1, 0 PRS_PLINK_1e.05 966 Poisoning by anticonvulsants and anti-Parkinsonism drugs Both 0 2 18 injuries & poisonings gray50 2, 0 1 1 1 1 PRS_PLINK_1e.05 967 Adverse effects of sedatives or other central nervous system depressants and anesthetics Both 0 12 18 injuries & poisonings gray50 12, 0 3 3 3 3 PRS_PLINK_1e.05 969 Poisoning by psychotropic agents Both 0 1 18 injuries & poisonings gray50 1, 0 PRS_PLINK_1e.05 972 Poisoning by agents primarily affecting the cardiovascular system Both 0 4 18 injuries & poisonings gray50 4, 0 1 1 1 1 PRS_PLINK_1e.05 972.6 Antihypertensive agents causing adverse effects Both 0 1 18 injuries & poisonings gray50 1, 0 PRS_PLINK_1e.05 974 Poisoning by water, mineral, and uric acid metabolism drugs Both 0 1 18 injuries & poisonings gray50 1, 0 PRS_PLINK_1e.05 975 Poisoning by agents primarily acting on the smooth and skeletal muscles and respiratory system Both 0 1 18 injuries & poisonings gray50 1, 0 PRS_PLINK_1e.05 976 Poisoning by agents primarily affecting skin & mucous membrane, ophthalmological, otorhinolaryngological, & dental drugs Both 1 0 18 injuries & poisonings gray50 0, 1 PRS_PLINK_1e.05 977 Personal history of allergy to medicinal agents Both 0 21 18 injuries & poisonings gray50 21, 0 6 5 5 5 PRS_PLINK_1e.05 979 Adverse drug events and drug allergies Both 5 38 18 injuries & poisonings gray50 38, 5 10, 1 9, 1 9, 1 10, 2 -0.00756 0.511 0.988 0.005 0.992 0.306 2.71 -1.14 1.7 0.502 0.299 0.319 0.00407 5.4 -0.709 1.54 0.645 0.191 0.492 0.00113 8.44 -0.939 1.67 0.573 0.242 0.391 0.00138 8.51 PRS_PLINK_1e.05 980 Encounter for long-term (current) use of antibiotics Both 3 13 1 infectious diseases blue 13, 3 4, 0 3, 0 3, 0 3, 3 0.64 0.833 0.442 0.354 1.9 0.487 17 1.18 2 0.554 0.257 3.26 0.219 157 PRS_PLINK_1e.05 985 Toxic effect of other metals Both 1 0 18 injuries & poisonings gray50 0, 1 PRS_PLINK_1e.05 989 Toxic effect of other substances, chiefly nonmedicinal as to source Both 1 2 18 injuries & poisonings gray50 2, 1 1, 1 1, 0 1, 1 1, 0 0.0344 77.8 1 0 1.04 0.562 1.1 -0.0444 192 1 0 0.957 0.748 1.17 PRS_PLINK_1e.05 990 Effects radiation NOS Both 0 21 18 injuries & poisonings gray50 21, 0 6 5 5 5 PRS_PLINK_1e.05 994 Sepsis and SIRS Both 1 27 18 injuries & poisonings gray50 27, 1 7, 0 7, 0 6, 1 7, 0 0.381 0.799 0.633 0.198 1.46 0.277 53.5 1.6 3.02 0.596 0.225 4.96 0.0405 4290 PRS_PLINK_1e.05 994.1 Systemic inflammatory response syndrome (SIRS) Both 0 2 18 injuries & poisonings gray50 2, 0 1 1 1 1 PRS_PLINK_1e.05 994.2 Sepsis Both 1 27 18 injuries & poisonings gray50 27, 1 7, 0 7, 0 6, 1 7, 0 0.37 0.829 0.655 0.184 1.45 0.273 81.8 0.945 2.29 0.679 0.168 2.57 0.0689 191 PRS_PLINK_1e.05 994.21 Septic shock Both 0 6 18 injuries & poisonings gray50 6, 0 2 1 1 2 PRS_PLINK_1e.05