prs_id analysis_type phecode phecode_description category sex or_value ci_lower ci_upper p_value cases controls significant prs_log10p beta_value se_beta q1_vs_q2_beta_value q1_vs_q2_se_beta q1_vs_q2_p_value q1_vs_q2_log10p q1_vs_q2_or_value q1_vs_q2_ci_lower q1_vs_q2_ci_upper q1_vs_q3_beta_value q1_vs_q3_se_beta q1_vs_q3_p_value q1_vs_q3_log10p q1_vs_q3_or_value q1_vs_q3_ci_lower q1_vs_q3_ci_upper q1_vs_q4_beta_value q1_vs_q4_se_beta q1_vs_q4_p_value q1_vs_q4_log10p q1_vs_q4_or_value q1_vs_q4_ci_lower q1_vs_q4_ci_upper ukb-melanoma-latest-gwas all 008 Intestinal infection Infectious Diseases Both 0.997 0.976 1.02 0.808 8932 89317 FALSE 0.0925886392254138 -0.00271 0.0111 0.0691 0.0314 0.0277 1.07 1.01 1.14 0.0435 0.0316 0.169 1.04 0.982 1.11 0.0127 0.032 0.692 1.01 0.951 1.08 ukb-melanoma-latest-gwas all 008.5 Bacterial enteritis Infectious Diseases Both 0.98 0.942 1.02 0.319 2723 27227 FALSE 0.496209316942819 -0.0201 0.0202 0.0471 0.0567 0.406 1.05 0.938 1.17 0.0422 0.0569 0.458 1.04 0.933 1.17 -0.00976 0.0579 0.866 0.99 0.884 1.11 ukb-melanoma-latest-gwas all 008.6 Viral Enteritis Infectious Diseases Both 0.996 0.929 1.07 0.917 863 8630 FALSE 0.0376306643299789 -0.00372 0.0358 0.0832 0.1 0.407 1.09 0.893 1.32 0.0424 0.101 0.676 1.04 0.855 1.27 -0.0193 0.103 0.851 0.981 0.801 1.2 ukb-melanoma-latest-gwas all 008.7 Intestinal infection due to protozoa Infectious Diseases Both 1.11 0.838 1.5 0.454 53 530 FALSE 0.342944147142896 0.108 0.145 -0.305 0.441 0.49 0.737 0.289 1.8 0.417 0.377 0.269 1.52 0.721 3.3 0.175 0.405 0.665 1.19 0.527 2.73 ukb-melanoma-latest-gwas all 008.52 Intestinal infection due to C. difficile Infectious Diseases Both 1.03 0.954 1.12 0.41 656 6560 FALSE 0.387216143280265 0.0338 0.041 0.09 0.116 0.436 1.09 0.872 1.37 0.0277 0.117 0.813 1.03 0.816 1.3 0.085 0.116 0.465 1.09 0.866 1.37 ukb-melanoma-latest-gwas all 010 Tuberculosis Infectious Diseases Both 0.899 0.768 1.05 0.18 174 1740 FALSE 0.744727494896694 -0.107 0.0797 0.0161 0.214 0.94 1.02 0.666 1.55 -0.2 0.227 0.379 0.819 0.52 1.28 -0.164 0.224 0.463 0.849 0.543 1.32 ukb-melanoma-latest-gwas all 038 Septicemia Infectious Diseases Both 1.01 0.975 1.04 0.709 4198 41980 FALSE 0.149353764816933 0.00608 0.0163 -0.0324 0.046 0.481 0.968 0.884 1.06 0.0318 0.0454 0.484 1.03 0.944 1.13 -0.0347 0.0463 0.453 0.966 0.882 1.06 ukb-melanoma-latest-gwas all 038.1 Gram negative septicemia Infectious Diseases Both 0.984 0.917 1.06 0.658 853 8530 FALSE 0.181774106386044 -0.0159 0.036 -0.0421 0.102 0.679 0.959 0.785 1.17 0.0621 0.0996 0.533 1.06 0.875 1.29 -0.112 0.104 0.279 0.894 0.729 1.1 ukb-melanoma-latest-gwas all 038.2 Gram positive septicemia Infectious Diseases Both 0.997 0.908 1.09 0.943 497 4970 FALSE 0.0254883072626717 -0.00335 0.0472 -0.204 0.134 0.128 0.815 0.625 1.06 -0.00914 0.128 0.943 0.991 0.77 1.28 -0.131 0.133 0.325 0.877 0.675 1.14 ukb-melanoma-latest-gwas all 041 Bacterial infection NOS Infectious Diseases Both 1 0.984 1.02 0.777 12100 120995 FALSE 0.109578981199086 0.00272 0.00958 -0.0307 0.0273 0.26 0.97 0.919 1.02 0.0309 0.0269 0.251 1.03 0.978 1.09 0.0197 0.0271 0.467 1.02 0.967 1.08 ukb-melanoma-latest-gwas all 041.1 Staphylococcus infections Infectious Diseases Both 1.01 0.977 1.05 0.454 3131 31305 FALSE 0.342944147142896 0.0141 0.0188 -0.0408 0.0536 0.446 0.96 0.864 1.07 0.0191 0.0529 0.718 1.02 0.919 1.13 0.0176 0.0532 0.74 1.02 0.917 1.13 ukb-melanoma-latest-gwas all 041.2 Streptococcus infection Infectious Diseases Both 0.992 0.943 1.04 0.751 1639 16390 FALSE 0.124360062995832 -0.00824 0.026 0.0501 0.0731 0.493 1.05 0.911 1.21 0.0277 0.0736 0.707 1.03 0.89 1.19 0.0177 0.0741 0.811 1.02 0.88 1.18 ukb-melanoma-latest-gwas all 041.4 E. coli Infectious Diseases Both 0.989 0.951 1.03 0.581 2724 27240 FALSE 0.235823867609669 -0.0111 0.0202 -0.107 0.057 0.0592 0.898 0.803 1 -0.079 0.0567 0.163 0.924 0.827 1.03 -0.0255 0.0563 0.65 0.975 0.873 1.09 ukb-melanoma-latest-gwas all 053 Herpes zoster Infectious Diseases Both 0.982 0.889 1.09 0.729 421 4210 FALSE 0.137272471682025 -0.0177 0.0511 0.00876 0.14 0.95 1.01 0.766 1.33 -0.252 0.15 0.0927 0.778 0.578 1.04 -0.0126 0.141 0.929 0.987 0.748 1.3 ukb-melanoma-latest-gwas all 053.1 Herpes zoster with nervous system complications Infectious Diseases Both 0.995 0.808 1.23 0.962 96 960 FALSE 0.0168249279621871 -0.00498 0.106 0.245 0.283 0.385 1.28 0.732 2.25 -0.195 0.313 0.533 0.823 0.436 1.53 -0.0613 0.302 0.839 0.941 0.513 1.72 ukb-melanoma-latest-gwas all 054 Herpes simplex Infectious Diseases Both 1.03 0.893 1.18 0.7 214 2140 FALSE 0.154901959985743 0.0276 0.0717 -0.0697 0.206 0.735 0.933 0.62 1.4 0.0719 0.2 0.719 1.07 0.724 1.6 0.0784 0.201 0.697 1.08 0.727 1.61 ukb-melanoma-latest-gwas all 070 Viral hepatitis Infectious Diseases Both 1.04 0.953 1.13 0.389 593 5930 FALSE 0.410050398674292 0.0372 0.0432 0.0132 0.122 0.914 1.01 0.797 1.29 -0.0174 0.123 0.887 0.983 0.772 1.25 0.0495 0.122 0.684 1.05 0.827 1.34 ukb-melanoma-latest-gwas all 070.1 Viral hepatitis A Infectious Diseases Both 0.895 0.698 1.15 0.375 69 690 FALSE 0.425968732272281 -0.11 0.124 0.278 0.332 0.403 1.32 0.684 2.59 0.155 0.337 0.645 1.17 0.597 2.31 -0.441 0.395 0.264 0.643 0.281 1.41 ukb-melanoma-latest-gwas all 070.2 Viral hepatitis B Infectious Diseases Both 1.02 0.856 1.22 0.795 134 1340 FALSE 0.0996328713435297 0.0235 0.0903 -0.145 0.254 0.567 0.865 0.52 1.43 -0.0345 0.251 0.891 0.966 0.586 1.59 -0.0211 0.251 0.933 0.979 0.594 1.61 ukb-melanoma-latest-gwas all 070.3 Viral hepatitis C Infectious Diseases Both 1.04 0.918 1.19 0.506 257 2570 FALSE 0.295849483160201 0.0434 0.0654 0.0283 0.184 0.878 1.03 0.716 1.48 -0.0256 0.186 0.891 0.975 0.674 1.41 0.0481 0.185 0.795 1.05 0.729 1.51 ukb-melanoma-latest-gwas all 071 Human immunodeficiency virus [HIV] disease Infectious Diseases Both 1.08 0.908 1.28 0.387 147 1470 FALSE 0.412289034981089 0.0748 0.0865 0.0844 0.239 0.724 1.09 0.677 1.75 -0.0507 0.247 0.837 0.951 0.582 1.55 0.0792 0.244 0.746 1.08 0.668 1.76 ukb-melanoma-latest-gwas all 071.1 HIV infection, symptomatic Infectious Diseases Both 1.1 0.911 1.34 0.305 117 1170 FALSE 0.515700160653214 0.0998 0.0974 0.0935 0.265 0.724 1.1 0.649 1.87 -0.14 0.283 0.62 0.869 0.492 1.52 0.172 0.273 0.529 1.19 0.692 2.05 ukb-melanoma-latest-gwas all 078 Viral warts & HPV Infectious Diseases Both 1.08 1.01 1.15 0.0272 1006 10060 TRUE 1.5654310959658 0.0735 0.0333 -0.0067 0.0959 0.944 0.993 0.823 1.2 0.0551 0.0948 0.561 1.06 0.877 1.27 0.163 0.0931 0.08 1.18 0.981 1.41 ukb-melanoma-latest-gwas all 079 Viral infection Infectious Diseases Both 0.99 0.952 1.03 0.616 2805 28050 FALSE 0.210419287835575 -0.00998 0.0199 0.065 0.0556 0.242 1.07 0.957 1.19 0.0209 0.0562 0.711 1.02 0.915 1.14 -0.0344 0.0572 0.548 0.966 0.864 1.08 ukb-melanoma-latest-gwas all 079.1 Varicella infection Infectious Diseases Both 1.04 0.804 1.34 0.785 65 650 FALSE 0.105130343254747 0.0348 0.128 -0.227 0.384 0.555 0.797 0.361 1.73 0.307 0.344 0.371 1.36 0.688 2.74 0.174 0.358 0.627 1.19 0.58 2.46 ukb-melanoma-latest-gwas all 079.2 Infectious mononucleosis Infectious Diseases Both 1.15 0.895 1.48 0.27 69 690 FALSE 0.568636235841013 0.14 0.127 0.48 0.367 0.19 1.62 0.784 3.46 0.371 0.376 0.323 1.45 0.684 3.16 0.401 0.368 0.276 1.49 0.721 3.2 ukb-melanoma-latest-gwas all 080 Postoperative infection Infectious Diseases Both 0.995 0.965 1.03 0.752 4489 44888 FALSE 0.123782159408358 -0.00497 0.0157 -0.0284 0.0442 0.52 0.972 0.891 1.06 -0.0371 0.0444 0.403 0.964 0.883 1.05 -0.0161 0.0443 0.716 0.984 0.902 1.07 ukb-melanoma-latest-gwas all 081 Infection/inflammation of internal prosthetic device; implant; and graft Infectious Diseases Both 1.01 0.965 1.05 0.769 2487 24870 FALSE 0.114073660198569 0.0062 0.0211 -0.043 0.0599 0.473 0.958 0.852 1.08 -0.0258 0.0598 0.666 0.975 0.867 1.1 0.0411 0.0592 0.487 1.04 0.928 1.17 ukb-melanoma-latest-gwas all 090 Sexually transmitted infections (not HIV or hepatitis) Infectious Diseases Both 0.927 0.728 1.18 0.53 73 730 FALSE 0.275724130399211 -0.076 0.121 -0.0866 0.324 0.789 0.917 0.479 1.75 -0.284 0.338 0.4 0.753 0.378 1.47 -0.322 0.339 0.342 0.725 0.363 1.42 ukb-melanoma-latest-gwas all 110 Dermatophytosis / Dermatomycosis Infectious Diseases Both 1.01 0.897 1.14 0.837 286 2860 FALSE 0.07727454200674 0.0127 0.0619 -0.0469 0.178 0.792 0.954 0.671 1.35 0.128 0.172 0.455 1.14 0.811 1.6 -0.00852 0.177 0.962 0.992 0.699 1.41 ukb-melanoma-latest-gwas all 110.1 Dermatophytosis Infectious Diseases Both 1.02 0.901 1.15 0.758 280 2800 FALSE 0.120330794367946 0.0193 0.0626 -0.0485 0.18 0.788 0.953 0.667 1.36 0.133 0.174 0.445 1.14 0.811 1.61 0.0206 0.178 0.908 1.02 0.718 1.45 ukb-melanoma-latest-gwas all 110.11 Dermatophytosis of nail Infectious Diseases Both 1.21 0.959 1.53 0.102 76 760 FALSE 0.991399828238082 0.193 0.118 0.31 0.362 0.392 1.36 0.661 2.88 0.514 0.35 0.143 1.67 0.838 3.45 0.539 0.348 0.122 1.72 0.865 3.53 ukb-melanoma-latest-gwas all 110.12 Althete's foot Infectious Diseases Both 0.9 0.759 1.07 0.227 141 1410 FALSE 0.643974142806877 -0.105 0.087 -0.252 0.236 0.285 0.777 0.485 1.24 -0.472 0.252 0.0618 0.624 0.374 1.02 -0.244 0.239 0.308 0.784 0.486 1.26 ukb-melanoma-latest-gwas all 112 Candidiasis Infectious Diseases Both 1.02 0.972 1.06 0.481 2134 21340 FALSE 0.317854923626168 0.0161 0.0228 -0.0238 0.0651 0.715 0.977 0.859 1.11 0.0623 0.0639 0.329 1.06 0.939 1.21 0.027 0.0647 0.677 1.03 0.905 1.17 ukb-melanoma-latest-gwas all 117 Mycoses Infectious Diseases Both 1.02 0.897 1.15 0.805 275 2750 FALSE 0.0942041196321315 0.0156 0.0631 0.0595 0.176 0.735 1.06 0.751 1.5 -0.0803 0.182 0.659 0.923 0.643 1.32 0.0609 0.176 0.73 1.06 0.751 1.51 ukb-melanoma-latest-gwas all 117.4 Aspergillosis Infectious Diseases Both 0.974 0.829 1.14 0.746 165 1650 FALSE 0.127261172527331 -0.0264 0.0813 0.278 0.223 0.212 1.32 0.852 2.06 -0.0697 0.24 0.772 0.933 0.578 1.5 0.0555 0.233 0.812 1.06 0.666 1.68 ukb-melanoma-latest-gwas all 130 Spirochetal infection Infectious Diseases Both 1 0.796 1.26 0.99 80 800 FALSE 0.00436480540245009 0.00151 0.115 -0.709 0.351 0.0433 0.492 0.236 0.977 -0.286 0.311 0.358 0.751 0.4 1.39 -0.13 0.299 0.663 0.878 0.483 1.59 ukb-melanoma-latest-gwas all 133 Arthropod-borne diseases Infectious Diseases Both 0.953 0.746 1.22 0.695 70 700 FALSE 0.158015195409886 -0.0483 0.123 0.641 0.34 0.0594 1.9 0.978 3.82 0.0983 0.37 0.79 1.1 0.522 2.35 0.0564 0.38 0.882 1.06 0.488 2.3 ukb-melanoma-latest-gwas all 134 Helminthiases Infectious Diseases Both 1.02 0.852 1.23 0.814 129 1290 FALSE 0.0893755951107988 0.0217 0.0921 -0.151 0.269 0.575 0.86 0.501 1.47 0.234 0.25 0.348 1.26 0.773 2.08 -0.0112 0.261 0.966 0.989 0.588 1.66 ukb-melanoma-latest-gwas all 134.1 Intestinal helminthiases Infectious Diseases Both 1.09 0.895 1.34 0.377 107 1070 FALSE 0.423658649794207 0.0892 0.101 -0.145 0.304 0.633 0.865 0.468 1.59 0.356 0.275 0.196 1.43 0.831 2.49 0.0911 0.288 0.752 1.1 0.618 1.95 ukb-melanoma-latest-gwas all 136 Other infectious and parasitic diseases Infectious Diseases Both 1.09 0.943 1.26 0.243 207 2070 FALSE 0.614393726401688 0.0848 0.0727 -0.223 0.212 0.293 0.8 0.525 1.21 -0.113 0.207 0.584 0.893 0.592 1.34 0.163 0.195 0.403 1.18 0.802 1.73 ukb-melanoma-latest-gwas all 145 Cancer of mouth Neoplasms Both 1.08 0.999 1.18 0.0517 648 6480 FALSE 1.28650945690606 0.0808 0.0415 0.0618 0.12 0.607 1.06 0.84 1.35 0.194 0.117 0.0987 1.21 0.964 1.53 0.118 0.119 0.322 1.13 0.891 1.42 ukb-melanoma-latest-gwas all 145.2 Cancer of tongue Neoplasms Both 1.02 0.909 1.15 0.712 310 3100 FALSE 0.147520006363144 0.0221 0.0598 0.257 0.17 0.131 1.29 0.926 1.81 0.228 0.171 0.183 1.26 0.897 1.76 0.0799 0.177 0.651 1.08 0.764 1.54 ukb-melanoma-latest-gwas all 145.3 Cancer of major salivary glands Neoplasms Both 1.17 0.952 1.43 0.135 105 1050 FALSE 0.869666231504994 0.154 0.103 -0.152 0.299 0.61 0.859 0.47 1.56 0.0738 0.287 0.797 1.08 0.608 1.91 0.12 0.282 0.669 1.13 0.646 1.99 ukb-melanoma-latest-gwas all 145.5 Cancer of the mouth floor Neoplasms Both 1.31 0.988 1.73 0.0558 54 540 FALSE 1.25336580106242 0.269 0.14 0.354 0.428 0.408 1.42 0.606 3.48 0.426 0.42 0.311 1.53 0.665 3.7 0.454 0.417 0.276 1.58 0.687 3.79 ukb-melanoma-latest-gwas all 149 Cancer of larynx, pharynx, nasal cavities Neoplasms Both 1.03 0.951 1.12 0.457 643 6428 FALSE 0.34008379993015 0.0308 0.0415 0.0152 0.119 0.898 1.02 0.804 1.28 0.087 0.117 0.458 1.09 0.867 1.37 0.0951 0.118 0.418 1.1 0.873 1.39 ukb-melanoma-latest-gwas all 149.1 Cancer of oropharynx Neoplasms Both 0.971 0.853 1.11 0.655 253 2528 FALSE 0.183758700008217 -0.0295 0.0659 -0.255 0.187 0.172 0.775 0.535 1.12 -0.0911 0.181 0.614 0.913 0.638 1.3 -0.103 0.182 0.572 0.903 0.63 1.29 ukb-melanoma-latest-gwas all 149.4 Cancer of larynx Neoplasms Both 1.07 0.945 1.22 0.273 265 2648 FALSE 0.563837352959244 0.0707 0.0645 0.291 0.188 0.122 1.34 0.925 1.95 0.298 0.188 0.112 1.35 0.932 1.96 0.249 0.191 0.192 1.28 0.881 1.88 ukb-melanoma-latest-gwas all 149.9 Cancer of of nasal cavities Neoplasms Both 1.04 0.794 1.37 0.762 57 570 FALSE 0.118045028660399 0.0414 0.137 0.119 0.39 0.76 1.13 0.514 2.51 0.401 0.386 0.299 1.49 0.694 3.31 0.104 0.404 0.796 1.11 0.49 2.54 ukb-melanoma-latest-gwas all 150 Cancer of esophagus Neoplasms Both 0.955 0.886 1.03 0.223 764 7640 FALSE 0.651695136951839 -0.0464 0.0381 -0.0585 0.106 0.581 0.943 0.766 1.16 -0.0466 0.106 0.66 0.954 0.775 1.17 -0.156 0.109 0.152 0.856 0.691 1.06 ukb-melanoma-latest-gwas all 151 Cancer of stomach Neoplasms Both 0.943 0.865 1.03 0.187 570 5700 FALSE 0.728158393463501 -0.0582 0.0441 -0.0899 0.122 0.463 0.914 0.718 1.16 -0.0751 0.122 0.539 0.928 0.729 1.18 -0.14 0.125 0.264 0.869 0.679 1.11 ukb-melanoma-latest-gwas all 153 Colorectal cancer Neoplasms Both 1.01 0.976 1.04 0.701 4610 46100 FALSE 0.154281982033341 0.00596 0.0155 0.0718 0.0437 0.1 1.07 0.986 1.17 0.0409 0.044 0.352 1.04 0.956 1.14 0.00551 0.0445 0.902 1.01 0.921 1.1 ukb-melanoma-latest-gwas all 153.2 Colon cancer Neoplasms Both 1.03 0.989 1.07 0.166 3109 31090 FALSE 0.779891911959945 0.0262 0.0189 0.076 0.0538 0.157 1.08 0.971 1.2 0.0886 0.0536 0.0985 1.09 0.984 1.21 0.0581 0.0542 0.284 1.06 0.953 1.18 ukb-melanoma-latest-gwas all 153.3 Malignant neoplasm of rectum, rectosigmoid junction, and anus Neoplasms Both 0.974 0.932 1.02 0.248 2165 21650 FALSE 0.605548319173784 -0.0261 0.0226 0.0659 0.0631 0.296 1.07 0.944 1.21 0.00939 0.0639 0.883 1.01 0.89 1.14 -0.0545 0.0651 0.403 0.947 0.833 1.08 ukb-melanoma-latest-gwas all 155 Cancer of liver and intrahepatic bile duct Neoplasms Both 1.06 0.96 1.18 0.233 402 4020 FALSE 0.632644078973981 0.0628 0.0527 0.0918 0.148 0.536 1.1 0.819 1.47 0.0167 0.151 0.912 1.02 0.756 1.37 0.0785 0.149 0.598 1.08 0.807 1.45 ukb-melanoma-latest-gwas all 155.1 Malignant neoplasm of liver, primary Neoplasms Both 1.14 0.963 1.35 0.127 158 1580 FALSE 0.896196279044043 0.129 0.0848 0.275 0.236 0.243 1.32 0.828 2.11 0.00583 0.251 0.981 1.01 0.61 1.66 0.225 0.239 0.346 1.25 0.783 2.02 ukb-melanoma-latest-gwas all 157 Pancreatic cancer Neoplasms Both 0.981 0.906 1.06 0.648 659 6590 FALSE 0.188424994129407 -0.0187 0.041 0.063 0.114 0.579 1.07 0.852 1.33 -0.0952 0.118 0.418 0.909 0.721 1.15 0.0131 0.116 0.91 1.01 0.807 1.27 ukb-melanoma-latest-gwas all 158 Neoplasm of unspecified nature of digestive system Neoplasms Both 0.993 0.932 1.06 0.834 1064 10640 FALSE 0.0788339493622613 -0.00677 0.0323 0.0642 0.0902 0.477 1.07 0.893 1.27 -0.0838 0.0934 0.369 0.92 0.765 1.1 0.0566 0.0906 0.532 1.06 0.886 1.26 ukb-melanoma-latest-gwas all 159 Malignant neoplasm of other and ill-defined sites within the digestive organs and peritoneum Neoplasms Both 0.992 0.965 1.02 0.581 5582 55820 FALSE 0.235823867609669 -0.00778 0.0141 0.0254 0.0397 0.523 1.03 0.949 1.11 0.0247 0.0397 0.534 1.02 0.948 1.11 -0.0182 0.0403 0.651 0.982 0.907 1.06 ukb-melanoma-latest-gwas all 159.2 Malignant neoplasm of small intestine, including duodenum Neoplasms Both 1.01 0.873 1.18 0.854 189 1890 FALSE 0.068542129310995 0.014 0.0762 0.301 0.219 0.168 1.35 0.879 2.09 0.38 0.217 0.0797 1.46 0.956 2.26 0.0659 0.231 0.776 1.07 0.675 1.69 ukb-melanoma-latest-gwas all 159.3 Malignant neoplasm of gallbladder and extrahepatic bile ducts Neoplasms Both 0.963 0.834 1.11 0.604 205 2050 FALSE 0.218963061378868 -0.0379 0.073 -0.308 0.206 0.135 0.735 0.487 1.1 -0.108 0.196 0.582 0.898 0.609 1.32 -0.258 0.205 0.21 0.773 0.513 1.16 ukb-melanoma-latest-gwas all 159.4 Malignant neoplasm of retroperitoneum and peritoneum Neoplasms Both 0.975 0.84 1.13 0.734 192 1920 FALSE 0.134303940083929 -0.0257 0.0755 -0.0101 0.218 0.963 0.99 0.643 1.52 0.11 0.212 0.605 1.12 0.733 1.7 0.0839 0.215 0.697 1.09 0.71 1.67 ukb-melanoma-latest-gwas all 164 Cancer of intrathoracic organs Neoplasms Both 1.13 0.862 1.47 0.375 60 600 FALSE 0.425968732272281 0.118 0.133 -0.157 0.386 0.685 0.855 0.389 1.87 0.213 0.367 0.561 1.24 0.595 2.61 0.0887 0.374 0.812 1.09 0.515 2.33 ukb-melanoma-latest-gwas all 165 Cancer within the respiratory system Neoplasms Both 1.03 0.987 1.07 0.192 2833 28319 FALSE 0.71669877129645 0.0258 0.0198 0.0258 0.0561 0.646 1.03 0.919 1.15 -0.00176 0.0566 0.975 0.998 0.893 1.12 0.0776 0.0558 0.164 1.08 0.969 1.21 ukb-melanoma-latest-gwas all 165.1 Cancer of bronchus; lung Neoplasms Both 1.03 0.983 1.07 0.241 2238 22380 FALSE 0.617982957425132 0.0261 0.0223 0.0348 0.0632 0.582 1.04 0.915 1.17 -0.00763 0.0639 0.905 0.992 0.875 1.12 0.0999 0.0627 0.111 1.11 0.977 1.25 ukb-melanoma-latest-gwas all 170 Cancer of bone and connective tissue Neoplasms Both 1.05 0.949 1.15 0.366 445 4447 FALSE 0.436518914605589 0.045 0.0498 -0.0457 0.145 0.752 0.955 0.718 1.27 0.223 0.136 0.102 1.25 0.956 1.64 -0.0176 0.144 0.903 0.983 0.74 1.3 ukb-melanoma-latest-gwas all 170.1 Bone cancer Neoplasms Both 0.945 0.79 1.13 0.535 131 1310 FALSE 0.271646217978772 -0.0564 0.0908 -0.589 0.271 0.0299 0.555 0.319 0.943 0.029 0.232 0.901 1.03 0.65 1.63 -0.393 0.256 0.125 0.675 0.403 1.12 ukb-melanoma-latest-gwas all 170.2 Cancer of connective tissue Neoplasms Both 1.08 0.961 1.21 0.202 331 3307 FALSE 0.694648630553376 0.0737 0.0578 0.0826 0.167 0.622 1.09 0.781 1.51 0.27 0.161 0.0942 1.31 0.955 1.8 0.0814 0.168 0.627 1.08 0.78 1.51 ukb-melanoma-latest-gwas all 172 Skin cancer Neoplasms Both 1.29 1.27 1.31 3.67e-173 13624 136233 TRUE 172.435333935748 0.255 0.0091 0.237 0.0284 5.68e-17 1.27 1.2 1.34 0.398 0.0275 1.78e-47 1.49 1.41 1.57 0.647 0.0265 4.03e-132 1.91 1.81 2.01 ukb-melanoma-latest-gwas all 172.1 Melanomas of skin, dx or hx Neoplasms Both 1.46 1.4 1.52 1.03e-76 2718 27180 TRUE 75.9871627752948 0.379 0.0205 0.333 0.0673 7.48e-07 1.39 1.22 1.59 0.577 0.0644 3.2e-19 1.78 1.57 2.02 0.927 0.0613 1.07e-51 2.53 2.24 2.85 ukb-melanoma-latest-gwas all 172.2 Other non-epithelial cancer of skin Neoplasms Both 1.27 1.24 1.29 3.73e-121 11030 110298 TRUE 120.428291168191 0.237 0.0101 0.225 0.0313 6.6e-13 1.25 1.18 1.33 0.373 0.0304 1.2e-34 1.45 1.37 1.54 0.605 0.0293 6.31e-95 1.83 1.73 1.94 ukb-melanoma-latest-gwas all 172.3 Carcinoma in situ of skin Neoplasms Both 1.37 1.26 1.48 2.97e-14 667 6670 TRUE 13.5272435506828 0.314 0.0413 0.383 0.13 0.00327 1.47 1.14 1.9 0.337 0.131 0.0104 1.4 1.08 1.82 0.89 0.121 1.62e-13 2.44 1.93 3.1 ukb-melanoma-latest-gwas all 172.11 Melanomas of skin Neoplasms Both 1.46 1.4 1.52 1.03e-76 2718 27180 TRUE 75.9871627752948 0.379 0.0205 0.333 0.0673 7.48e-07 1.39 1.22 1.59 0.577 0.0644 3.2e-19 1.78 1.57 2.02 0.927 0.0613 1.07e-51 2.53 2.24 2.85 ukb-melanoma-latest-gwas all 173 Neoplasm of uncertain behavior of skin Neoplasms Both 1.22 1.05 1.42 0.0112 182 1820 TRUE 1.95078197732982 0.198 0.0782 0.346 0.233 0.137 1.41 0.894 2.26 0.39 0.232 0.093 1.48 0.936 2.36 0.462 0.228 0.0431 1.59 1.02 2.51 ukb-melanoma-latest-gwas all 174 Breast cancer Neoplasms Both 1.03 1.01 1.05 0.0012 12771 127136 TRUE 2.92081875395238 0.0302 0.00933 0.0128 0.0265 0.628 1.01 0.962 1.07 0.0116 0.0265 0.661 1.01 0.96 1.07 0.0673 0.0263 0.0105 1.07 1.02 1.13 ukb-melanoma-latest-gwas all 174.1 Breast cancer [female] Neoplasms Female 1.03 1.01 1.05 0.00114 12549 124973 TRUE 2.94309514866353 0.0306 0.00941 0.0145 0.0268 0.587 1.01 0.963 1.07 0.0111 0.0268 0.68 1.01 0.959 1.07 0.069 0.0265 0.00932 1.07 1.02 1.13 ukb-melanoma-latest-gwas all 174.3 Neoplasm of uncertain behavior of breast Neoplasms Both 0.884 0.73 1.07 0.203 115 1150 FALSE 0.692503962086787 -0.123 0.0969 -0.273 0.263 0.298 0.761 0.45 1.28 -0.299 0.267 0.263 0.741 0.433 1.25 -0.377 0.27 0.162 0.686 0.398 1.17 ukb-melanoma-latest-gwas all 174.11 Malignant neoplasm of female breast Neoplasms Female 1.03 1.01 1.05 0.00127 11767 117670 TRUE 2.89619627904404 0.0313 0.00972 0.0246 0.0276 0.374 1.02 0.971 1.08 0.0222 0.0277 0.423 1.02 0.968 1.08 0.0714 0.0275 0.0093 1.07 1.02 1.13 ukb-melanoma-latest-gwas all 175 Acquired absence of breast Neoplasms Female 1.03 0.991 1.08 0.126 2406 24060 FALSE 0.899629454882437 0.0329 0.0215 -0.00921 0.0609 0.88 0.991 0.879 1.12 0.00461 0.0607 0.939 1 0.892 1.13 0.0247 0.0605 0.683 1.03 0.91 1.15 ukb-melanoma-latest-gwas all 180 Cervical cancer and dysplasia Neoplasms Female 0.973 0.941 1.01 0.122 3640 36400 FALSE 0.913640169325252 -0.027 0.0174 0.0224 0.0485 0.644 1.02 0.93 1.12 -0.0572 0.0495 0.247 0.944 0.857 1.04 -0.0479 0.0495 0.333 0.953 0.865 1.05 ukb-melanoma-latest-gwas all 180.1 Cervical cancer Neoplasms Female 0.956 0.909 1.01 0.0818 1655 16550 FALSE 1.08724669632868 -0.0449 0.0258 0.0984 0.0712 0.167 1.1 0.96 1.27 -0.034 0.0733 0.643 0.967 0.837 1.12 -0.0905 0.0747 0.226 0.913 0.789 1.06 ukb-melanoma-latest-gwas all 180.3 Cervical intraepithelial neoplasia [CIN] [Cervical dysplasia] Neoplasms Female 0.988 0.944 1.03 0.597 2081 20810 FALSE 0.224025668870631 -0.0122 0.0231 -0.0214 0.0646 0.74 0.979 0.862 1.11 -0.0673 0.0653 0.303 0.935 0.822 1.06 -0.0327 0.0649 0.614 0.968 0.852 1.1 ukb-melanoma-latest-gwas all 182 Malignant neoplasm of uterus Neoplasms Female 0.997 0.941 1.06 0.916 1288 12880 FALSE 0.0381045263321496 -0.0031 0.0293 0.0866 0.0815 0.288 1.09 0.929 1.28 -0.0505 0.0841 0.549 0.951 0.806 1.12 0.00106 0.0833 0.99 1 0.85 1.18 ukb-melanoma-latest-gwas all 184 Cancer of other female genital organs Neoplasms Female 0.98 0.94 1.02 0.332 2467 24670 FALSE 0.478861916295964 -0.0205 0.0212 0.0575 0.0589 0.329 1.06 0.944 1.19 -0.0257 0.0601 0.669 0.975 0.866 1.1 -0.036 0.0606 0.552 0.965 0.857 1.09 ukb-melanoma-latest-gwas all 184.1 Malignant neoplasm of ovary and other uterine adnexa Neoplasms Female 0.977 0.935 1.02 0.317 2131 21310 FALSE 0.498940737782248 -0.0228 0.0228 0.0616 0.0633 0.33 1.06 0.939 1.2 -0.0203 0.0646 0.754 0.98 0.863 1.11 -0.0431 0.0653 0.509 0.958 0.843 1.09 ukb-melanoma-latest-gwas all 184.2 Cancer of other female genital organs (excluding uterus and ovary) Neoplasms Female 0.965 0.857 1.09 0.549 305 3050 FALSE 0.260427655549908 -0.0361 0.0603 -0.011 0.167 0.947 0.989 0.711 1.37 -0.112 0.171 0.511 0.894 0.637 1.25 -0.0726 0.17 0.669 0.93 0.665 1.3 ukb-melanoma-latest-gwas all 184.11 Malignant neoplasm of ovary Neoplasms Female 0.977 0.934 1.02 0.314 2108 21080 FALSE 0.503070351926785 -0.0231 0.0229 0.0539 0.0637 0.397 1.06 0.932 1.2 -0.0184 0.0648 0.777 0.982 0.865 1.11 -0.0506 0.0656 0.44 0.951 0.836 1.08 ukb-melanoma-latest-gwas all 185 Cancer of prostate Neoplasms Male 1 0.98 1.03 0.719 6719 64751 FALSE 0.143271109617117 0.00464 0.0129 -0.00484 0.0366 0.895 0.995 0.926 1.07 0.0375 0.0363 0.301 1.04 0.967 1.11 0.0199 0.0365 0.586 1.02 0.95 1.1 ukb-melanoma-latest-gwas all 187 Cancer of other male genital organs Neoplasms Male 1 0.968 1.04 0.796 3114 31140 FALSE 0.0990869322623309 0.00488 0.0189 -0.0251 0.0537 0.64 0.975 0.878 1.08 0.0224 0.0532 0.674 1.02 0.921 1.14 0.0292 0.0533 0.584 1.03 0.927 1.14 ukb-melanoma-latest-gwas all 187.1 Malignant neoplasm of unspecified male genital organ Neoplasms Male 0.997 0.959 1.04 0.878 2835 28350 FALSE 0.0565054840938974 -0.00304 0.0198 -0.0429 0.0563 0.446 0.958 0.858 1.07 0.0212 0.0556 0.703 1.02 0.916 1.14 0.0175 0.0558 0.754 1.02 0.912 1.14 ukb-melanoma-latest-gwas all 187.2 Malignant neoplasm of testis Neoplasms Male 1 0.967 1.04 0.815 2973 29730 FALSE 0.0888423912600234 0.00453 0.0193 -0.0149 0.055 0.787 0.985 0.885 1.1 0.0317 0.0545 0.561 1.03 0.928 1.15 0.0367 0.0546 0.502 1.04 0.932 1.15 ukb-melanoma-latest-gwas all 187.8 Neoplasm of uncertain behavior of male genital organs Neoplasms Male 0.908 0.746 1.11 0.331 110 1100 FALSE 0.480172006224281 -0.0967 0.0994 0.116 0.259 0.653 1.12 0.674 1.88 -0.485 0.298 0.104 0.616 0.335 1.1 -0.146 0.278 0.6 0.864 0.496 1.5 ukb-melanoma-latest-gwas all 189 Cancer of urinary organs (incl. kidney and bladder) Neoplasms Both 0.981 0.95 1.01 0.243 4183 41830 FALSE 0.614393726401688 -0.019 0.0163 0.0173 0.0453 0.703 1.02 0.931 1.11 -0.0349 0.046 0.448 0.966 0.882 1.06 -0.0622 0.0463 0.18 0.94 0.858 1.03 ukb-melanoma-latest-gwas all 189.1 Cancer of kidney and renal pelvis Neoplasms Both 0.999 0.938 1.06 0.986 1075 10750 FALSE 0.00612308505878879 -0.000564 0.0321 -0.0186 0.0909 0.838 0.982 0.821 1.17 0.000298 0.091 0.997 1 0.837 1.2 0.0273 0.0903 0.763 1.03 0.861 1.23 ukb-melanoma-latest-gwas all 189.2 Cancer of bladder Neoplasms Both 0.993 0.952 1.04 0.73 2424 24240 FALSE 0.136677139879544 -0.00738 0.0214 0.0266 0.0596 0.656 1.03 0.914 1.15 -0.0185 0.0603 0.759 0.982 0.872 1.1 -0.0574 0.0609 0.346 0.944 0.838 1.06 ukb-melanoma-latest-gwas all 189.4 Malignant neoplasm of other urinary organs Neoplasms Both 0.95 0.8 1.13 0.553 144 1440 FALSE 0.257274868695302 -0.0516 0.087 -0.262 0.236 0.266 0.769 0.48 1.22 -0.431 0.246 0.0801 0.65 0.396 1.05 -0.235 0.236 0.319 0.791 0.494 1.26 ukb-melanoma-latest-gwas all 189.11 Malignant neoplasm of kidney, except pelvis Neoplasms Both 1.01 0.943 1.07 0.862 1032 10320 FALSE 0.0644927341752872 0.00568 0.0327 -0.0241 0.0933 0.796 0.976 0.813 1.17 0.0385 0.0924 0.677 1.04 0.867 1.25 0.0351 0.0924 0.704 1.04 0.864 1.24 ukb-melanoma-latest-gwas all 189.12 Malignant neoplasm of renal pelvis Neoplasms Both 0.908 0.704 1.17 0.447 66 660 FALSE 0.349692476868063 -0.0969 0.128 -0.299 0.348 0.389 0.741 0.366 1.47 -0.578 0.374 0.122 0.561 0.257 1.17 -0.187 0.33 0.572 0.83 0.426 1.6 ukb-melanoma-latest-gwas all 189.21 Malignant neoplasm of bladder Neoplasms Both 0.987 0.944 1.03 0.564 2148 21480 FALSE 0.248720896016658 -0.0131 0.0227 0.0462 0.0633 0.465 1.05 0.925 1.19 0.00585 0.0639 0.927 1.01 0.887 1.14 -0.065 0.0651 0.318 0.937 0.825 1.06 ukb-melanoma-latest-gwas all 190 Cancer of eye Neoplasms Both 1.03 0.885 1.21 0.668 176 1760 FALSE 0.175223537524454 0.0339 0.079 -0.329 0.231 0.153 0.719 0.452 1.13 -0.0943 0.217 0.665 0.91 0.591 1.4 0.0402 0.212 0.849 1.04 0.685 1.58 ukb-melanoma-latest-gwas all 191 Manlignant and unknown neoplasms of brain and nervous system Neoplasms Both 0.997 0.922 1.08 0.944 692 6920 FALSE 0.0250280057019311 -0.00278 0.0399 0.145 0.112 0.196 1.16 0.928 1.44 0.0801 0.115 0.485 1.08 0.865 1.36 0.0328 0.115 0.776 1.03 0.824 1.3 ukb-melanoma-latest-gwas all 191.1 Cancer of brain and nervous system Neoplasms Both 1.01 0.929 1.1 0.77 568 5680 FALSE 0.113509274827518 0.0129 0.044 0.224 0.124 0.0708 1.25 0.981 1.6 0.0747 0.128 0.56 1.08 0.838 1.39 0.0639 0.128 0.617 1.07 0.829 1.37 ukb-melanoma-latest-gwas all 191.11 Cancer of brain Neoplasms Both 1.01 0.925 1.11 0.788 524 5240 FALSE 0.103473782510445 0.0123 0.0458 0.205 0.129 0.112 1.23 0.953 1.58 0.0699 0.133 0.6 1.07 0.825 1.39 0.0805 0.132 0.543 1.08 0.835 1.41 ukb-melanoma-latest-gwas all 193 Thyroid cancer Neoplasms Both 1.03 0.924 1.15 0.584 358 3580 FALSE 0.233587152887601 0.0304 0.0556 -0.0967 0.157 0.537 0.908 0.666 1.24 0.0183 0.153 0.905 1.02 0.753 1.38 -0.0667 0.157 0.671 0.935 0.686 1.27 ukb-melanoma-latest-gwas all 194 Cancer of other endocrine glands Neoplasms Both 1.08 0.874 1.33 0.472 95 950 FALSE 0.326058001365912 0.0764 0.106 -0.171 0.308 0.579 0.843 0.453 1.56 -0.0583 0.297 0.844 0.943 0.52 1.71 0.152 0.289 0.598 1.16 0.657 2.08 ukb-melanoma-latest-gwas all 195 Cancer, suspected or other Neoplasms Both 1.07 1.05 1.09 4.31e-17 17028 165982 TRUE 16.3655227298393 0.068 0.0081 0.0325 0.0234 0.165 1.03 0.987 1.08 0.0871 0.0232 0.00017 1.09 1.04 1.14 0.17 0.0228 8.65e-14 1.19 1.13 1.24 ukb-melanoma-latest-gwas all 195.1 Malignant neoplasm, other Neoplasms Both 1.07 1.05 1.09 4.8e-17 16305 159816 TRUE 16.3187587626244 0.0694 0.00827 0.0376 0.0239 0.116 1.04 0.991 1.09 0.0869 0.0237 0.000245 1.09 1.04 1.14 0.176 0.0233 4.26e-14 1.19 1.14 1.25 ukb-melanoma-latest-gwas all 197 Chemotherapy Neoplasms Both 1.02 1 1.03 0.0259 21492 213706 TRUE 1.58670023591875 0.016 0.00719 0.0118 0.0204 0.56 1.01 0.972 1.05 0.027 0.0203 0.184 1.03 0.987 1.07 0.0225 0.0204 0.27 1.02 0.983 1.06 ukb-melanoma-latest-gwas all 198 Secondary malignant neoplasm Neoplasms Both 1.03 1 1.05 0.0216 9585 95830 TRUE 1.66554624884907 0.0247 0.0108 0.0216 0.0307 0.482 1.02 0.962 1.09 0.06 0.0305 0.0489 1.06 1 1.13 0.0615 0.0306 0.0442 1.06 1 1.13 ukb-melanoma-latest-gwas all 198.1 Secondary malignancy of lymph nodes Neoplasms Both 1.02 0.995 1.05 0.104 5355 53549 FALSE 0.98296666070122 0.0234 0.0144 0.0503 0.041 0.22 1.05 0.97 1.14 0.0693 0.0409 0.0901 1.07 0.989 1.16 0.0598 0.0411 0.146 1.06 0.979 1.15 ukb-melanoma-latest-gwas all 198.2 Secondary malignancy of respiratory organs Neoplasms Both 1.02 0.978 1.07 0.341 2263 22619 FALSE 0.467245621007502 0.0211 0.0222 -0.0285 0.0633 0.652 0.972 0.858 1.1 0.0476 0.0624 0.446 1.05 0.928 1.19 0.0483 0.0625 0.44 1.05 0.928 1.19 ukb-melanoma-latest-gwas all 198.3 Secondary malignant neoplasm of digestive systems Neoplasms Both 0.984 0.934 1.04 0.544 1542 15416 FALSE 0.26440110030182 -0.0162 0.0268 -0.129 0.0752 0.086 0.879 0.758 1.02 -0.0829 0.0744 0.265 0.92 0.795 1.06 -0.0994 0.0751 0.186 0.905 0.781 1.05 ukb-melanoma-latest-gwas all 198.4 Secondary malignant neoplasm of liver Neoplasms Both 1.02 0.984 1.07 0.25 2661 26602 FALSE 0.602059991327962 0.0235 0.0204 0.00862 0.0585 0.883 1.01 0.899 1.13 0.0892 0.0576 0.122 1.09 0.977 1.22 0.0548 0.0581 0.346 1.06 0.942 1.18 ukb-melanoma-latest-gwas all 198.5 Secondary malignancy of brain/spine Neoplasms Both 1.06 0.984 1.13 0.131 846 8460 FALSE 0.882728704344236 0.0546 0.0361 0.0289 0.104 0.781 1.03 0.839 1.26 0.055 0.104 0.595 1.06 0.862 1.3 0.151 0.102 0.138 1.16 0.953 1.42 ukb-melanoma-latest-gwas all 198.6 Secondary malignancy of bone Neoplasms Both 1.03 0.985 1.08 0.202 2156 21553 FALSE 0.694648630553376 0.0289 0.0227 -0.0169 0.0652 0.796 0.983 0.865 1.12 0.0675 0.0641 0.293 1.07 0.943 1.21 0.0925 0.0639 0.148 1.1 0.968 1.24 ukb-melanoma-latest-gwas all 198.7 Secondary malignant neoplasm of skin Neoplasms Both 1.07 0.921 1.24 0.371 187 1869 FALSE 0.430626090384954 0.0683 0.0764 0.155 0.214 0.468 1.17 0.766 1.79 -0.00876 0.221 0.968 0.991 0.64 1.54 0.03 0.219 0.891 1.03 0.668 1.59 ukb-melanoma-latest-gwas all 199 Neoplasm of uncertain behavior Neoplasms Both 1.01 0.955 1.06 0.77 1433 14330 FALSE 0.113509274827518 0.00812 0.0278 0.123 0.0786 0.118 1.13 0.969 1.32 0.104 0.0793 0.19 1.11 0.95 1.3 0.0365 0.0804 0.65 1.04 0.886 1.21 ukb-melanoma-latest-gwas all 199.4 Neurofibromatosis Neoplasms Both 0.799 0.644 0.989 0.0374 95 950 TRUE 1.42712839779952 -0.225 0.108 -0.229 0.284 0.42 0.795 0.449 1.39 -0.536 0.311 0.0849 0.585 0.309 1.08 -0.245 0.291 0.399 0.783 0.436 1.39 ukb-melanoma-latest-gwas all 200 Myeloproliferative disease Neoplasms Both 1.07 0.998 1.14 0.0573 1000 10000 FALSE 1.24184537803261 0.0633 0.0333 0.13 0.0951 0.171 1.14 0.945 1.37 0.0949 0.0957 0.321 1.1 0.911 1.33 0.138 0.0951 0.146 1.15 0.953 1.38 ukb-melanoma-latest-gwas all 200.1 Polycythemia vera Neoplasms Both 1.14 1.02 1.26 0.0164 390 3900 TRUE 1.7851561519523 0.128 0.0533 0.0581 0.157 0.711 1.06 0.778 1.44 0.267 0.15 0.0759 1.31 0.973 1.76 0.183 0.153 0.23 1.2 0.89 1.63 ukb-melanoma-latest-gwas all 201 Hodgkin's disease Neoplasms Both 0.957 0.843 1.09 0.498 261 2610 FALSE 0.302770657240282 -0.0438 0.0646 0.0646 0.18 0.719 1.07 0.748 1.52 0.108 0.18 0.551 1.11 0.781 1.59 -0.141 0.189 0.455 0.868 0.597 1.26 ukb-melanoma-latest-gwas all 202 Cancer of other lymphoid, histiocytic tissue Neoplasms Both 0.996 0.954 1.04 0.865 2297 22970 FALSE 0.0629838925351858 -0.00373 0.022 -0.00576 0.0616 0.926 0.994 0.881 1.12 0.00204 0.0616 0.974 1 0.888 1.13 -0.0533 0.0626 0.395 0.948 0.839 1.07 ukb-melanoma-latest-gwas all 202.2 Non-Hodgkins lymphoma Neoplasms Both 0.998 0.951 1.05 0.933 1821 18210 FALSE 0.0301183562535 -0.00207 0.0247 -0.0543 0.0694 0.434 0.947 0.826 1.09 -0.0294 0.0692 0.671 0.971 0.848 1.11 -0.0337 0.0695 0.628 0.967 0.844 1.11 ukb-melanoma-latest-gwas all 202.21 Nodular lymphoma Neoplasms Both 0.985 0.885 1.1 0.782 370 3700 FALSE 0.106793246940152 -0.0151 0.0546 0.219 0.153 0.152 1.24 0.922 1.68 0.063 0.158 0.69 1.06 0.78 1.45 0.0784 0.158 0.62 1.08 0.792 1.48 ukb-melanoma-latest-gwas all 202.24 Large cell lymphoma Neoplasms Both 1.01 0.932 1.11 0.733 584 5840 FALSE 0.134896025358872 0.0149 0.0435 -0.144 0.124 0.247 0.866 0.678 1.11 -0.0348 0.122 0.775 0.966 0.76 1.23 0.0155 0.12 0.897 1.02 0.802 1.29 ukb-melanoma-latest-gwas all 204 Leukemia Neoplasms Both 1.02 0.969 1.07 0.476 1696 16954 FALSE 0.322393047279507 0.0182 0.0256 -0.0909 0.0722 0.208 0.913 0.792 1.05 -0.0418 0.0714 0.559 0.959 0.834 1.1 -0.0369 0.0716 0.606 0.964 0.837 1.11 ukb-melanoma-latest-gwas all 204.1 Lymphoid leukemia Neoplasms Both 1.04 0.958 1.14 0.334 587 5864 FALSE 0.476253533188435 0.0419 0.0434 -0.155 0.127 0.224 0.857 0.667 1.1 0.159 0.119 0.18 1.17 0.929 1.48 -0.00278 0.123 0.982 0.997 0.783 1.27 ukb-melanoma-latest-gwas all 204.2 Myeloid leukemia Neoplasms Both 1.04 0.944 1.14 0.444 486 4860 FALSE 0.35261702988538 0.0365 0.0477 -0.135 0.138 0.328 0.874 0.665 1.15 0.0777 0.131 0.554 1.08 0.835 1.4 0.00876 0.133 0.948 1.01 0.776 1.31 ukb-melanoma-latest-gwas all 204.4 Multiple myeloma Neoplasms Both 1.02 0.932 1.11 0.705 559 5590 FALSE 0.151810883008601 0.0168 0.0444 0.0239 0.123 0.845 1.02 0.805 1.3 -0.1 0.127 0.428 0.904 0.704 1.16 -0.0457 0.125 0.715 0.955 0.747 1.22 ukb-melanoma-latest-gwas all 204.11 Lymphoid leukemia, acute Neoplasms Both 1.08 0.831 1.41 0.541 60 600 FALSE 0.266802734893431 0.081 0.132 -1.01 0.465 0.0301 0.365 0.131 0.904 0.291 0.347 0.401 1.34 0.674 2.69 -0.094 0.358 0.793 0.91 0.442 1.87 ukb-melanoma-latest-gwas all 204.12 Lymphoid leukemia, chronic Neoplasms Both 1.03 0.94 1.13 0.536 514 5134 FALSE 0.27083521030723 0.0287 0.0464 -0.147 0.135 0.275 0.863 0.662 1.12 0.135 0.126 0.284 1.15 0.893 1.47 -0.0426 0.132 0.746 0.958 0.739 1.24 ukb-melanoma-latest-gwas all 204.21 Myeloid leukemia, acute Neoplasms Both 1.05 0.939 1.18 0.385 336 3360 FALSE 0.414539270491499 0.0498 0.0574 -0.0545 0.166 0.743 0.947 0.681 1.31 0.157 0.158 0.322 1.17 0.857 1.6 0.0554 0.162 0.733 1.06 0.768 1.46 ukb-melanoma-latest-gwas all 204.22 Myeloid leukemia, chronic Neoplasms Both 1.09 0.924 1.29 0.302 157 1570 FALSE 0.519993057042849 0.0864 0.0838 -0.335 0.248 0.177 0.715 0.433 1.17 0.000811 0.23 0.997 1 0.635 1.58 0.0758 0.226 0.737 1.08 0.69 1.69 ukb-melanoma-latest-gwas all 208 Benign neoplasm of colon Neoplasms Both 1.01 0.998 1.03 0.0952 19890 192225 FALSE 1.02136305161553 0.0125 0.00749 0.0271 0.0212 0.202 1.03 0.986 1.07 0.0401 0.0212 0.0586 1.04 0.999 1.09 0.0362 0.0213 0.0891 1.04 0.994 1.08 ukb-melanoma-latest-gwas all 210 Benign neoplasm of lip, oral cavity, and pharynx Neoplasms Both 1.06 0.989 1.13 0.0996 981 9810 FALSE 1.0017406615763 0.0552 0.0335 -0.0597 0.0961 0.534 0.942 0.78 1.14 -0.0433 0.0957 0.651 0.958 0.793 1.16 0.117 0.0927 0.205 1.12 0.938 1.35 ukb-melanoma-latest-gwas all 211 Benign neoplasm of other parts of digestive system Neoplasms Both 1 0.977 1.03 0.744 5256 52560 FALSE 0.128427064454121 0.00475 0.0145 0.0233 0.041 0.57 1.02 0.944 1.11 0.00942 0.0412 0.819 1.01 0.931 1.09 0.028 0.0411 0.496 1.03 0.949 1.11 ukb-melanoma-latest-gwas all 212 Benign neoplasm of respiratory and intrathoracic organs Neoplasms Both 0.965 0.864 1.08 0.53 348 3480 FALSE 0.275724130399211 -0.0353 0.0562 0.0336 0.156 0.83 1.03 0.76 1.41 -0.0156 0.158 0.921 0.984 0.721 1.34 -0.0838 0.161 0.603 0.92 0.669 1.26 ukb-melanoma-latest-gwas all 213 Benign neoplasm of bone and articular cartilage Neoplasms Both 1.03 0.918 1.16 0.608 320 3200 FALSE 0.216096420727265 0.0301 0.0588 0.125 0.165 0.448 1.13 0.819 1.57 0.0854 0.167 0.609 1.09 0.784 1.51 0.0408 0.168 0.808 1.04 0.747 1.45 ukb-melanoma-latest-gwas all 214 Lipoma Neoplasms Both 1.01 0.984 1.04 0.439 6246 62460 FALSE 0.357535479757879 0.0103 0.0133 0.0569 0.0376 0.13 1.06 0.983 1.14 -0.016 0.0382 0.676 0.984 0.913 1.06 0.0625 0.0377 0.0973 1.06 0.989 1.15 ukb-melanoma-latest-gwas all 214.1 Lipoma of skin and subcutaneous tissue Neoplasms Both 1.01 0.981 1.04 0.455 4593 45930 FALSE 0.341988603342888 0.0116 0.0155 0.0419 0.0438 0.339 1.04 0.957 1.14 -0.0374 0.0446 0.402 0.963 0.883 1.05 0.0688 0.0437 0.115 1.07 0.983 1.17 ukb-melanoma-latest-gwas all 215 Other benign neoplasm of connective and other soft tissue Neoplasms Both 1.02 0.96 1.09 0.494 1109 11090 FALSE 0.306273051076353 0.0216 0.0316 -0.0666 0.0899 0.459 0.936 0.784 1.12 -0.0797 0.0903 0.377 0.923 0.773 1.1 0.0965 0.0871 0.268 1.1 0.928 1.31 ukb-melanoma-latest-gwas all 216 Benign neoplasm of skin Neoplasms Both 1.1 1.07 1.12 1.54e-14 7679 76785 TRUE 13.8124792791635 0.0926 0.0121 0.0818 0.035 0.0195 1.09 1.01 1.16 0.126 0.0348 0.000305 1.13 1.06 1.21 0.227 0.0341 2.71e-11 1.26 1.17 1.34 ukb-melanoma-latest-gwas all 217 Vascular hamartomas and non-neoplastic nevi Neoplasms Both 1.06 0.974 1.15 0.187 649 6490 FALSE 0.728158393463501 0.0545 0.0413 0.15 0.119 0.206 1.16 0.921 1.47 0.115 0.119 0.333 1.12 0.888 1.42 0.182 0.118 0.124 1.2 0.951 1.52 ukb-melanoma-latest-gwas all 217.1 Nevus, non-neoplastic Neoplasms Both 1.07 0.979 1.16 0.141 597 5970 FALSE 0.85078088734462 0.0634 0.0431 0.156 0.124 0.207 1.17 0.917 1.49 0.11 0.125 0.378 1.12 0.874 1.43 0.206 0.123 0.0933 1.23 0.966 1.57 ukb-melanoma-latest-gwas all 218 Benign neoplasm of uterus Neoplasms Female 1.02 1 1.04 0.0242 10507 105069 TRUE 1.61618463401957 0.0232 0.0103 0.057 0.0291 0.0502 1.06 1 1.12 0.0334 0.0293 0.254 1.03 0.976 1.09 0.0506 0.0292 0.0833 1.05 0.993 1.11 ukb-melanoma-latest-gwas all 218.1 Uterine leiomyoma Neoplasms Female 1.02 1 1.05 0.0219 10245 102449 TRUE 1.65955588515988 0.0239 0.0104 0.0677 0.0294 0.0215 1.07 1.01 1.13 0.0365 0.0297 0.219 1.04 0.979 1.1 0.0559 0.0296 0.0592 1.06 0.998 1.12 ukb-melanoma-latest-gwas all 218.2 Other benign neoplasm of uterus Neoplasms Female 0.968 0.867 1.08 0.556 353 3530 FALSE 0.254925208417943 -0.033 0.056 -0.303 0.16 0.0582 0.739 0.538 1.01 -0.0612 0.151 0.684 0.941 0.699 1.26 -0.216 0.157 0.167 0.805 0.591 1.1 ukb-melanoma-latest-gwas all 220 Benign neoplasm of ovary Neoplasms Female 1.02 0.965 1.07 0.499 1476 14760 FALSE 0.30189945437661 0.0185 0.0274 0.15 0.0767 0.0501 1.16 1 1.35 0.017 0.079 0.83 1.02 0.871 1.19 0.0514 0.0786 0.514 1.05 0.902 1.23 ukb-melanoma-latest-gwas all 221 Benign neoplasm of other female genital organs Neoplasms Female 0.964 0.839 1.11 0.601 220 2200 FALSE 0.22112552799726 -0.0369 0.0706 -0.329 0.195 0.0919 0.72 0.488 1.05 -0.427 0.201 0.0333 0.652 0.436 0.966 -0.133 0.188 0.479 0.876 0.604 1.27 ukb-melanoma-latest-gwas all 222 Benign neoplasm of male genital organs Neoplasms Male 0.839 0.713 0.987 0.0333 160 1600 TRUE 1.47755576649368 -0.175 0.0824 0.112 0.215 0.602 1.12 0.732 1.71 -0.278 0.235 0.237 0.757 0.473 1.2 -0.372 0.243 0.126 0.69 0.423 1.11 ukb-melanoma-latest-gwas all 223 Benign neoplasm of kidney and other urinary organs Neoplasms Both 0.956 0.818 1.12 0.573 174 1740 FALSE 0.24184537803261 -0.0447 0.0793 -0.232 0.222 0.296 0.793 0.509 1.23 -0.0859 0.212 0.686 0.918 0.602 1.4 -0.304 0.226 0.179 0.738 0.469 1.15 ukb-melanoma-latest-gwas all 224 Benign neoplasm of eye Neoplasms Both 0.989 0.826 1.19 0.906 130 1300 FALSE 0.0428718023231869 -0.0108 0.0913 0.203 0.258 0.432 1.22 0.736 2.05 0.282 0.255 0.268 1.33 0.802 2.21 -0.0401 0.273 0.883 0.961 0.556 1.66 ukb-melanoma-latest-gwas all 224.1 Benign neoplasm of eye, uveal Neoplasms Both 1.17 0.91 1.5 0.216 68 680 FALSE 0.665546248849069 0.155 0.125 0.429 0.382 0.261 1.54 0.721 3.4 0.634 0.374 0.0903 1.89 0.903 4.14 0.475 0.381 0.212 1.61 0.755 3.57 ukb-melanoma-latest-gwas all 225 Benign neoplasm of brain and other parts of nervous system Neoplasms Both 1.02 0.948 1.09 0.614 830 8300 FALSE 0.211831628858832 0.0184 0.0365 -0.0088 0.104 0.932 0.991 0.808 1.22 0.0563 0.102 0.582 1.06 0.865 1.29 -0.00516 0.104 0.96 0.995 0.811 1.22 ukb-melanoma-latest-gwas all 225.1 Benign neoplasm of brain, cranial nerves, meninges Neoplasms Both 1.03 0.957 1.11 0.431 776 7760 FALSE 0.365522729839268 0.0298 0.0378 0.0398 0.108 0.712 1.04 0.842 1.29 0.0878 0.107 0.41 1.09 0.886 1.35 0.0461 0.108 0.669 1.05 0.847 1.3 ukb-melanoma-latest-gwas all 225.2 Benign neoplasm of spinal cord, meninges Neoplasms Both 0.866 0.663 1.13 0.282 59 590 FALSE 0.549750891680639 -0.144 0.134 -0.554 0.379 0.144 0.575 0.262 1.21 -0.701 0.379 0.064 0.496 0.225 1.04 -0.262 0.342 0.444 0.77 0.385 1.51 ukb-melanoma-latest-gwas all 226 Benign neoplasm of thyroid glands Neoplasms Both 1.02 0.902 1.15 0.752 285 2850 FALSE 0.123782159408358 0.0196 0.0621 -0.2 0.176 0.256 0.819 0.577 1.16 -0.138 0.174 0.429 0.871 0.617 1.23 -0.0313 0.17 0.854 0.969 0.693 1.35 ukb-melanoma-latest-gwas all 227 Benign neoplasm of other endocrine glands and related structures Neoplasms Both 1.06 0.987 1.13 0.113 878 8780 FALSE 0.94692155651658 0.0565 0.0356 0.0364 0.102 0.722 1.04 0.848 1.27 0.0906 0.101 0.371 1.09 0.897 1.34 0.144 0.101 0.154 1.15 0.947 1.41 ukb-melanoma-latest-gwas all 227.1 Benign neoplasm of adrenal gland Neoplasms Both 1.06 0.906 1.23 0.489 186 1860 FALSE 0.31069114087638 0.0536 0.0774 -0.0177 0.223 0.937 0.982 0.631 1.53 0.255 0.212 0.231 1.29 0.85 1.97 0.0372 0.224 0.868 1.04 0.665 1.62 ukb-melanoma-latest-gwas all 227.2 Benign neoplasm of parathyroid gland Neoplasms Both 1.1 0.991 1.23 0.0718 371 3710 FALSE 1.1438755557577 0.0985 0.0547 0.149 0.161 0.354 1.16 0.846 1.6 0.194 0.159 0.223 1.21 0.888 1.66 0.348 0.156 0.0261 1.42 1.04 1.93 ukb-melanoma-latest-gwas all 227.3 Benign neoplasm of pituitary gland and craniopharyngeal duct (pouch) Neoplasms Both 0.994 0.884 1.12 0.916 311 3110 FALSE 0.0381045263321496 -0.00625 0.0595 -0.0429 0.166 0.796 0.958 0.69 1.33 -0.0765 0.167 0.647 0.926 0.666 1.29 -0.0347 0.166 0.835 0.966 0.695 1.34 ukb-melanoma-latest-gwas all 228 Hemangioma and lymphangioma, any site Neoplasms Both 1.02 0.967 1.07 0.488 1602 16020 FALSE 0.311580177997289 0.0182 0.0263 0.105 0.0742 0.158 1.11 0.96 1.28 0.0586 0.0752 0.436 1.06 0.915 1.23 0.0682 0.0753 0.365 1.07 0.924 1.24 ukb-melanoma-latest-gwas all 229 Benign neoplasm of unspecified sites Neoplasms Both 1.02 0.973 1.06 0.48 2400 23998 FALSE 0.318758762624413 0.0152 0.0215 0.078 0.0607 0.198 1.08 0.96 1.22 0.0427 0.0612 0.485 1.04 0.926 1.18 0.0494 0.0614 0.421 1.05 0.931 1.19 ukb-melanoma-latest-gwas all 240 Simple and unspecified goiter Endocrine/metabolic Both 0.953 0.876 1.04 0.257 602 6020 FALSE 0.590066876668705 -0.0485 0.0427 -0.0343 0.121 0.776 0.966 0.762 1.22 0.0406 0.119 0.732 1.04 0.825 1.32 -0.0833 0.122 0.496 0.92 0.723 1.17 ukb-melanoma-latest-gwas all 241 Nontoxic nodular goiter Endocrine/metabolic Both 1.01 0.952 1.08 0.713 1142 11420 FALSE 0.146910470148134 0.0115 0.0312 -0.0108 0.0874 0.902 0.989 0.833 1.17 -0.0751 0.0888 0.398 0.928 0.779 1.1 0.00987 0.0875 0.91 1.01 0.851 1.2 ukb-melanoma-latest-gwas all 241.1 Nontoxic uninodular goiter Endocrine/metabolic Both 0.952 0.866 1.05 0.303 472 4720 FALSE 0.518557371497695 -0.0497 0.0482 -0.14 0.134 0.299 0.87 0.667 1.13 -0.111 0.133 0.406 0.895 0.688 1.16 -0.124 0.135 0.358 0.883 0.676 1.15 ukb-melanoma-latest-gwas all 241.2 Nontoxic multinodular goiter Endocrine/metabolic Both 1.06 0.98 1.15 0.14 679 6790 FALSE 0.853871964321762 0.0597 0.0405 0.0855 0.114 0.455 1.09 0.87 1.36 -0.051 0.118 0.666 0.95 0.753 1.2 0.125 0.114 0.271 1.13 0.907 1.42 ukb-melanoma-latest-gwas all 242 Thyrotoxicosis with or without goiter Endocrine/metabolic Both 0.997 0.95 1.05 0.91 1849 18490 FALSE 0.0409586076789064 -0.00276 0.0245 -0.0481 0.0698 0.491 0.953 0.831 1.09 0.0728 0.068 0.284 1.08 0.941 1.23 -0.022 0.0699 0.753 0.978 0.853 1.12 ukb-melanoma-latest-gwas all 242.1 Graves' disease Endocrine/metabolic Both 0.969 0.88 1.07 0.518 456 4560 FALSE 0.285670240254767 -0.0318 0.0491 -0.0383 0.137 0.78 0.962 0.735 1.26 -0.0852 0.139 0.54 0.918 0.698 1.21 -0.0241 0.138 0.861 0.976 0.744 1.28 ukb-melanoma-latest-gwas all 242.2 Toxic multinodular goiter Endocrine/metabolic Both 0.902 0.727 1.12 0.342 91 910 FALSE 0.465973893943865 -0.103 0.109 -0.165 0.301 0.585 0.848 0.462 1.54 0.0778 0.287 0.786 1.08 0.611 1.92 -0.33 0.316 0.297 0.719 0.378 1.34 ukb-melanoma-latest-gwas all 242.3 Exophthalmos Endocrine/metabolic Both 1.11 0.923 1.33 0.273 129 1290 FALSE 0.563837352959244 0.101 0.0919 -0.118 0.264 0.655 0.889 0.524 1.5 0.0352 0.259 0.892 1.04 0.618 1.74 0.104 0.254 0.681 1.11 0.671 1.84 ukb-melanoma-latest-gwas all 244 Hypothyroidism Endocrine/metabolic Both 0.997 0.98 1.01 0.735 14646 145476 FALSE 0.133712660915805 -0.00295 0.0087 0.0293 0.0246 0.233 1.03 0.981 1.08 0.0321 0.0246 0.191 1.03 0.984 1.08 0.00213 0.0248 0.932 1 0.955 1.05 ukb-melanoma-latest-gwas all 244.1 Secondary hypothyroidism Endocrine/metabolic Both 0.993 0.934 1.06 0.832 1111 11110 FALSE 0.0798766737092761 -0.00673 0.0316 0.0872 0.0879 0.321 1.09 0.918 1.3 0.00165 0.0898 0.985 1 0.84 1.19 -0.0432 0.091 0.635 0.958 0.801 1.15 ukb-melanoma-latest-gwas all 244.2 Acquired hypothyroidism Endocrine/metabolic Both 1.09 0.887 1.34 0.41 101 1010 FALSE 0.387216143280265 0.0859 0.104 0.23 0.302 0.446 1.26 0.691 2.32 0.329 0.305 0.28 1.39 0.759 2.58 0.275 0.301 0.361 1.32 0.725 2.42 ukb-melanoma-latest-gwas all 244.4 Hypothyroidism NOS Endocrine/metabolic Both 0.995 0.978 1.01 0.6 13961 139245 FALSE 0.221848749616356 -0.00467 0.00891 0.0323 0.0252 0.199 1.03 0.983 1.09 0.0351 0.0252 0.163 1.04 0.986 1.09 -0.00131 0.0255 0.959 0.999 0.95 1.05 ukb-melanoma-latest-gwas all 245 Thyroiditis Endocrine/metabolic Both 0.947 0.84 1.07 0.373 294 2940 FALSE 0.428291168191312 -0.0545 0.0611 -0.0347 0.171 0.84 0.966 0.689 1.35 0.082 0.166 0.621 1.09 0.783 1.51 -0.23 0.18 0.201 0.794 0.555 1.13 ukb-melanoma-latest-gwas all 245.2 Chronic thyroiditis Endocrine/metabolic Both 0.963 0.839 1.11 0.592 224 2240 FALSE 0.22767829327708 -0.0374 0.0698 0.0826 0.199 0.679 1.09 0.733 1.61 0.261 0.19 0.169 1.3 0.895 1.9 -0.168 0.211 0.425 0.845 0.555 1.28 ukb-melanoma-latest-gwas all 245.21 Chronic lymphocytic thyroiditis Endocrine/metabolic Both 0.947 0.822 1.09 0.451 211 2110 FALSE 0.345823458122039 -0.0543 0.0719 0.0442 0.205 0.829 1.05 0.697 1.57 0.26 0.194 0.181 1.3 0.886 1.91 -0.215 0.218 0.323 0.806 0.521 1.24 ukb-melanoma-latest-gwas all 246 Other disorders of thyroid Endocrine/metabolic Both 0.935 0.844 1.04 0.201 403 4030 FALSE 0.696803942579511 -0.067 0.0524 0.0566 0.141 0.687 1.06 0.803 1.4 -0.326 0.154 0.0338 0.722 0.532 0.975 -0.0722 0.146 0.62 0.93 0.698 1.24 ukb-melanoma-latest-gwas all 250 Diabetes mellitus Endocrine/metabolic Both 1.03 1.01 1.04 0.000738 19898 186647 TRUE 3.13194363817696 0.0253 0.0075 0.0425 0.0214 0.0469 1.04 1 1.09 0.0975 0.0212 4.2e-06 1.1 1.06 1.15 0.058 0.0214 0.00681 1.06 1.02 1.11 ukb-melanoma-latest-gwas all 250.1 Type 1 diabetes Endocrine/metabolic Both 1.03 0.992 1.08 0.112 2657 26570 FALSE 0.950781977329818 0.0325 0.0204 -0.0319 0.0581 0.582 0.969 0.864 1.09 -0.0144 0.0579 0.804 0.986 0.88 1.1 0.0612 0.0573 0.285 1.06 0.95 1.19 ukb-melanoma-latest-gwas all 250.2 Type 2 diabetes Endocrine/metabolic Both 1.02 1.01 1.04 0.00359 18671 176412 TRUE 2.44490555142168 0.0225 0.00774 0.0462 0.0221 0.0364 1.05 1 1.09 0.105 0.0218 1.59e-06 1.11 1.06 1.16 0.0544 0.0222 0.0141 1.06 1.01 1.1 ukb-melanoma-latest-gwas all 250.4 Abnormal glucose Endocrine/metabolic Both 1.04 0.959 1.12 0.358 684 6840 FALSE 0.446116973356126 0.037 0.0403 0.084 0.115 0.466 1.09 0.867 1.36 0.143 0.114 0.21 1.15 0.922 1.45 0.124 0.116 0.283 1.13 0.902 1.42 ukb-melanoma-latest-gwas all 250.5 Glycosuria or Acetonuria Endocrine/metabolic Both 1 0.838 1.2 0.96 131 1310 FALSE 0.0177287669604316 0.0046 0.0914 -0.205 0.25 0.412 0.814 0.493 1.34 -0.37 0.261 0.156 0.691 0.408 1.15 -0.0871 0.246 0.723 0.917 0.562 1.49 ukb-melanoma-latest-gwas all 250.6 Polyneuropathy in diabetes Endocrine/metabolic Both 1.02 0.912 1.14 0.754 354 3540 FALSE 0.122628654130226 0.0175 0.0557 0.169 0.16 0.291 1.18 0.864 1.63 0.263 0.157 0.0926 1.3 0.957 1.77 0.0367 0.165 0.824 1.04 0.749 1.44 ukb-melanoma-latest-gwas all 250.7 Diabetic retinopathy Endocrine/metabolic Both 0.971 0.918 1.03 0.304 1335 13350 FALSE 0.517126416391246 -0.0296 0.0288 0.0917 0.0802 0.253 1.1 0.937 1.28 0.0106 0.0818 0.897 1.01 0.861 1.19 -0.0407 0.0829 0.623 0.96 0.816 1.13 ukb-melanoma-latest-gwas all 250.11 Type 1 diabetes with ketoacidosis Endocrine/metabolic Both 0.938 0.821 1.07 0.349 239 2390 FALSE 0.45717457304082 -0.0636 0.0679 -0.308 0.186 0.0979 0.735 0.507 1.06 -0.377 0.19 0.0473 0.686 0.469 0.995 -0.221 0.183 0.226 0.802 0.558 1.15 ukb-melanoma-latest-gwas all 250.12 Type 1 diabetes with renal manifestations Endocrine/metabolic Both 1.09 0.863 1.38 0.456 77 770 FALSE 0.341035157335565 0.0886 0.119 0.422 0.332 0.204 1.52 0.792 3 0.0092 0.352 0.979 1.01 0.496 2.06 0.183 0.344 0.594 1.2 0.604 2.42 ukb-melanoma-latest-gwas all 250.21 Type 2 diabetes with ketoacidosis Endocrine/metabolic Both 1.17 0.955 1.44 0.127 105 1050 FALSE 0.896196279044043 0.158 0.103 0.171 0.3 0.568 1.19 0.653 2.18 -0.00454 0.314 0.988 0.995 0.529 1.87 0.565 0.281 0.0444 1.76 1.02 3.12 ukb-melanoma-latest-gwas all 250.22 Type 2 diabetes with renal manifestations Endocrine/metabolic Both 0.941 0.814 1.09 0.414 202 2020 FALSE 0.382999658879101 -0.0604 0.0739 0.102 0.198 0.608 1.11 0.749 1.64 -0.294 0.219 0.181 0.746 0.481 1.15 0.0195 0.207 0.925 1.02 0.676 1.54 ukb-melanoma-latest-gwas all 250.23 Type 2 diabetes with ophthalmic manifestations Endocrine/metabolic Both 0.974 0.919 1.03 0.362 1294 12940 FALSE 0.441291429466834 -0.0266 0.0292 0.0561 0.0819 0.493 1.06 0.901 1.24 0.035 0.0824 0.671 1.04 0.881 1.22 -0.0388 0.0841 0.644 0.962 0.816 1.13 ukb-melanoma-latest-gwas all 250.24 Type 2 diabetes with neurological manifestations Endocrine/metabolic Both 1.04 0.957 1.14 0.338 575 5750 FALSE 0.471083299722345 0.042 0.0439 0.278 0.128 0.0291 1.32 1.03 1.7 0.342 0.126 0.00657 1.41 1.1 1.81 0.16 0.132 0.225 1.17 0.906 1.52 ukb-melanoma-latest-gwas all 250.41 Impaired fasting glucose Endocrine/metabolic Both 1.08 0.955 1.23 0.208 266 2660 FALSE 0.681936665037238 0.0815 0.0647 -0.1 0.188 0.594 0.905 0.623 1.31 0.114 0.18 0.525 1.12 0.787 1.6 0.117 0.181 0.518 1.12 0.786 1.61 ukb-melanoma-latest-gwas all 250.42 Other abnormal glucose Endocrine/metabolic Both 1.01 0.915 1.12 0.806 419 4190 FALSE 0.0936649581949093 0.0126 0.0513 0.126 0.146 0.386 1.13 0.852 1.51 0.113 0.146 0.44 1.12 0.84 1.49 0.0902 0.148 0.542 1.09 0.818 1.46 ukb-melanoma-latest-gwas all 251.1 Hypoglycemia Endocrine/metabolic Both 0.985 0.921 1.05 0.652 940 9395 FALSE 0.18575240426808 -0.0155 0.0343 0.127 0.0947 0.181 1.13 0.943 1.37 -0.0212 0.0979 0.828 0.979 0.808 1.19 -0.0529 0.099 0.593 0.948 0.781 1.15 ukb-melanoma-latest-gwas all 252 Disorders of parathyroid gland Endocrine/metabolic Both 1.05 0.983 1.13 0.141 877 8770 FALSE 0.85078088734462 0.0523 0.0355 -0.23 0.104 0.0263 0.794 0.648 0.973 -0.0358 0.099 0.718 0.965 0.794 1.17 0.0596 0.0969 0.539 1.06 0.878 1.28 ukb-melanoma-latest-gwas all 252.1 Hyperparathyroidism Endocrine/metabolic Both 1.06 0.986 1.14 0.115 781 7810 FALSE 0.939302159646388 0.0594 0.0377 -0.225 0.111 0.0419 0.799 0.642 0.992 -0.0158 0.105 0.88 0.984 0.8 1.21 0.108 0.103 0.295 1.11 0.91 1.36 ukb-melanoma-latest-gwas all 252.2 Hypoparathyroidism Endocrine/metabolic Both 1.02 0.859 1.21 0.819 142 1420 FALSE 0.0867160982395816 0.0199 0.0872 -0.132 0.245 0.589 0.876 0.537 1.42 -0.0484 0.244 0.843 0.953 0.587 1.54 -0.0766 0.241 0.751 0.926 0.573 1.49 ukb-melanoma-latest-gwas all 253 Disorders of the pituitary gland and its hypothalamic control Endocrine/metabolic Both 1.04 0.958 1.12 0.376 694 6940 FALSE 0.424812155072339 0.0353 0.0399 -0.0643 0.113 0.57 0.938 0.75 1.17 -0.0138 0.112 0.902 0.986 0.791 1.23 0.0157 0.112 0.888 1.02 0.816 1.27 ukb-melanoma-latest-gwas all 253.1 Pituitary hyperfunction Endocrine/metabolic Both 0.97 0.835 1.13 0.688 189 1890 FALSE 0.162411561764489 -0.0305 0.076 -0.207 0.213 0.33 0.813 0.531 1.24 -0.0217 0.204 0.915 0.979 0.653 1.46 -0.248 0.216 0.25 0.78 0.507 1.19 ukb-melanoma-latest-gwas all 253.2 Pituitary hypofunction Endocrine/metabolic Both 1.11 0.974 1.26 0.118 263 2630 FALSE 0.928117992693875 0.101 0.0647 -0.187 0.194 0.337 0.83 0.563 1.22 0.208 0.179 0.244 1.23 0.867 1.76 0.163 0.18 0.366 1.18 0.826 1.68 ukb-melanoma-latest-gwas all 253.3 Diabetes insipidus Endocrine/metabolic Both 0.943 0.762 1.17 0.582 93 930 FALSE 0.235077015350112 -0.0591 0.107 0.107 0.294 0.716 1.11 0.62 2.01 -0.0794 0.309 0.797 0.924 0.497 1.71 -0.0116 0.303 0.97 0.989 0.539 1.81 ukb-melanoma-latest-gwas all 253.7 Other disorders of neurohypophysis Endocrine/metabolic Both 1.02 0.866 1.2 0.814 158 1580 FALSE 0.0893755951107988 0.0195 0.0829 0.132 0.225 0.558 1.14 0.732 1.78 -0.258 0.246 0.295 0.773 0.471 1.26 0.0112 0.231 0.961 1.01 0.639 1.6 ukb-melanoma-latest-gwas all 253.11 Acromegaly and gigantism Endocrine/metabolic Both 0.97 0.785 1.2 0.773 95 950 FALSE 0.111820506081675 -0.0307 0.107 -0.389 0.305 0.202 0.678 0.365 1.24 -0.066 0.284 0.816 0.936 0.531 1.64 -0.278 0.295 0.347 0.757 0.418 1.36 ukb-melanoma-latest-gwas all 255 Disorders of adrenal glands Endocrine/metabolic Both 0.971 0.895 1.05 0.476 642 6420 FALSE 0.322393047279507 -0.0296 0.0415 -0.176 0.116 0.127 0.838 0.667 1.05 -0.0971 0.114 0.393 0.907 0.726 1.13 -0.186 0.117 0.111 0.83 0.66 1.04 ukb-melanoma-latest-gwas all 255.1 Adrenal hyperfunction Endocrine/metabolic Both 1.05 0.899 1.22 0.546 182 1820 FALSE 0.262807357295263 0.047 0.0779 0.227 0.23 0.323 1.25 0.798 1.99 0.313 0.227 0.168 1.37 0.875 2.16 0.326 0.227 0.152 1.39 0.886 2.19 ukb-melanoma-latest-gwas all 255.2 Adrenal hypofunction Endocrine/metabolic Both 0.934 0.838 1.04 0.214 364 3640 FALSE 0.669586226650809 -0.0683 0.055 -0.387 0.156 0.013 0.679 0.498 0.921 -0.0742 0.145 0.608 0.929 0.698 1.23 -0.356 0.155 0.0221 0.701 0.515 0.95 ukb-melanoma-latest-gwas all 255.11 Cushing's syndrome Endocrine/metabolic Both 0.991 0.809 1.21 0.932 103 1030 FALSE 0.0305840876460186 -0.00877 0.103 -0.0353 0.297 0.905 0.965 0.532 1.75 0.244 0.279 0.381 1.28 0.736 2.24 -0.0599 0.297 0.84 0.942 0.519 1.71 ukb-melanoma-latest-gwas all 255.12 Hyperaldosteronism Endocrine/metabolic Both 1.14 0.895 1.45 0.29 76 760 FALSE 0.537602002101044 0.128 0.121 0.386 0.357 0.28 1.47 0.725 3.08 0.386 0.369 0.295 1.47 0.709 3.15 0.504 0.36 0.161 1.66 0.814 3.48 ukb-melanoma-latest-gwas all 255.21 Glucocorticoid deficiency Endocrine/metabolic Both 0.927 0.831 1.03 0.169 361 3610 FALSE 0.772113295386326 -0.076 0.0553 -0.385 0.156 0.0135 0.68 0.499 0.923 -0.0846 0.145 0.56 0.919 0.69 1.22 -0.38 0.157 0.0151 0.684 0.501 0.929 ukb-melanoma-latest-gwas all 256 Ovarian dysfunction Endocrine/metabolic Female 1.01 0.885 1.15 0.888 244 2440 FALSE 0.051587034221399 0.00942 0.0671 0.212 0.19 0.264 1.24 0.851 1.8 0.204 0.19 0.284 1.23 0.844 1.79 0.00415 0.201 0.984 1 0.675 1.49 ukb-melanoma-latest-gwas all 256.4 Polycystic ovaries Endocrine/metabolic Female 1.01 0.877 1.17 0.875 209 2090 FALSE 0.0579919469776868 0.0114 0.0725 0.227 0.204 0.266 1.26 0.84 1.89 0.165 0.208 0.427 1.18 0.783 1.78 0.0515 0.214 0.81 1.05 0.689 1.61 ukb-melanoma-latest-gwas all 257 Testicular dysfunction Endocrine/metabolic Male 1.11 0.94 1.3 0.224 163 1630 FALSE 0.649751981665837 0.0999 0.0822 -0.578 0.25 0.0206 0.561 0.338 0.913 -0.28 0.23 0.223 0.756 0.478 1.19 0.144 0.21 0.493 1.16 0.763 1.75 ukb-melanoma-latest-gwas all 257.1 Testicular hypofunction Endocrine/metabolic Male 1.11 0.937 1.31 0.23 154 1540 FALSE 0.638272163982407 0.101 0.0845 -0.533 0.257 0.0379 0.587 0.349 0.969 -0.218 0.236 0.356 0.804 0.502 1.28 0.168 0.218 0.442 1.18 0.77 1.82 ukb-melanoma-latest-gwas all 258 Iatrogenic endocrine disorders Endocrine/metabolic Both 1.09 0.889 1.34 0.4 102 1020 FALSE 0.397940008672038 0.0877 0.104 0.321 0.297 0.28 1.38 0.766 2.52 0.378 0.298 0.205 1.46 0.81 2.67 0.194 0.311 0.534 1.21 0.652 2.28 ukb-melanoma-latest-gwas all 259 Other endocrine disorders Endocrine/metabolic Both 1.14 0.964 1.35 0.123 152 1520 FALSE 0.910094888560602 0.131 0.0851 0.161 0.246 0.513 1.17 0.722 1.92 0.107 0.246 0.665 1.11 0.683 1.82 0.297 0.239 0.215 1.35 0.84 2.17 ukb-melanoma-latest-gwas all 260 Protein-calorie malnutrition Endocrine/metabolic Both 1.06 0.914 1.22 0.455 202 2019 FALSE 0.341988603342888 0.0552 0.0739 0.14 0.213 0.511 1.15 0.756 1.76 0.224 0.21 0.286 1.25 0.828 1.9 0.168 0.214 0.433 1.18 0.776 1.81 ukb-melanoma-latest-gwas all 261 Vitamin deficiency Endocrine/metabolic Both 0.999 0.942 1.06 0.986 1210 12100 FALSE 0.00612308505878879 -0.000527 0.0303 -0.109 0.086 0.205 0.897 0.757 1.06 -0.0246 0.0842 0.77 0.976 0.827 1.15 -0.0354 0.0849 0.677 0.965 0.817 1.14 ukb-melanoma-latest-gwas all 261.2 Vitamin B-complex deficiencies Endocrine/metabolic Both 1.01 0.938 1.09 0.763 755 7550 FALSE 0.11747546204512 0.0116 0.0384 -0.0285 0.11 0.796 0.972 0.783 1.21 0.0451 0.108 0.676 1.05 0.846 1.29 0.0672 0.108 0.535 1.07 0.865 1.32 ukb-melanoma-latest-gwas all 261.4 Vitamin D deficiency Endocrine/metabolic Both 0.962 0.873 1.06 0.428 449 4490 FALSE 0.368556230986828 -0.0392 0.0494 -0.1 0.135 0.46 0.905 0.693 1.18 -0.204 0.139 0.141 0.815 0.62 1.07 -0.182 0.138 0.188 0.834 0.634 1.09 ukb-melanoma-latest-gwas all 261.41 Rickets or osteomalacia Endocrine/metabolic Both 0.904 0.715 1.14 0.396 77 770 FALSE 0.402304814074488 -0.1 0.118 -0.473 0.324 0.144 0.623 0.321 1.18 -0.456 0.327 0.163 0.634 0.325 1.21 -0.369 0.317 0.243 0.691 0.364 1.29 ukb-melanoma-latest-gwas all 262 Mineral deficiency NEC Endocrine/metabolic Both 1.07 0.939 1.22 0.301 242 2420 FALSE 0.521433504406157 0.0695 0.0672 -0.0198 0.187 0.916 0.98 0.678 1.42 -0.3 0.2 0.135 0.741 0.497 1.1 0.131 0.182 0.471 1.14 0.797 1.63 ukb-melanoma-latest-gwas all 269 Proteinuria Endocrine/metabolic Both 1.05 0.94 1.18 0.379 339 3390 FALSE 0.421360790031928 0.0501 0.057 -0.033 0.166 0.842 0.967 0.697 1.34 0.141 0.159 0.377 1.15 0.842 1.58 0.106 0.161 0.511 1.11 0.81 1.53 ukb-melanoma-latest-gwas all 270 Disorders of protein plasma/amino-acid transport and metabolism Endocrine/metabolic Both 1.09 0.966 1.22 0.166 304 3040 FALSE 0.779891911959945 0.0834 0.0601 0.0175 0.181 0.923 1.02 0.712 1.45 0.255 0.172 0.138 1.29 0.921 1.81 0.303 0.171 0.0758 1.35 0.969 1.9 ukb-melanoma-latest-gwas all 270.3 Disorders of plasma protein metabolism Endocrine/metabolic Both 1.09 0.957 1.24 0.195 261 2610 FALSE 0.709965388637482 0.0841 0.0649 0.04 0.192 0.835 1.04 0.712 1.52 0.157 0.187 0.401 1.17 0.81 1.7 0.297 0.183 0.104 1.35 0.941 1.94 ukb-melanoma-latest-gwas all 270.32 Paraproteinemia Endocrine/metabolic Both 1.13 0.969 1.31 0.12 191 1910 FALSE 0.920818753952375 0.118 0.0758 -0.0898 0.228 0.694 0.914 0.58 1.44 0.0962 0.219 0.66 1.1 0.714 1.7 0.394 0.209 0.0595 1.48 0.985 2.25 ukb-melanoma-latest-gwas all 270.35 Macroglobulinemia Endocrine/metabolic Both 1.01 0.785 1.29 0.963 69 690 FALSE 0.0163737128754655 0.00582 0.124 0.191 0.353 0.588 1.21 0.597 2.49 0.397 0.343 0.248 1.49 0.756 3 0.0438 0.376 0.907 1.04 0.487 2.23 ukb-melanoma-latest-gwas all 271 Disorders of carbohydrate transport and metabolism Endocrine/metabolic Both 0.882 0.75 1.04 0.123 163 1621 FALSE 0.910094888560602 -0.126 0.0818 -0.438 0.231 0.0574 0.645 0.406 1.01 -0.0841 0.216 0.697 0.919 0.599 1.41 -0.482 0.233 0.0384 0.618 0.387 0.974 ukb-melanoma-latest-gwas all 271.3 Intestinal disaccharidase deficiencies and disaccharide malabsorption Endocrine/metabolic Both 0.914 0.769 1.09 0.309 141 1401 FALSE 0.510041520575165 -0.0895 0.0879 -0.506 0.25 0.0426 0.603 0.364 0.982 -0.129 0.232 0.577 0.879 0.554 1.39 -0.448 0.246 0.0687 0.639 0.389 1.03 ukb-melanoma-latest-gwas all 272 Disorders of lipoid metabolism Endocrine/metabolic Both 1.01 1 1.03 0.0123 34960 235908 TRUE 1.9100948885606 0.0145 0.00581 0.026 0.0165 0.115 1.03 0.994 1.06 0.0416 0.0164 0.0115 1.04 1.01 1.08 0.0375 0.0165 0.0233 1.04 1.01 1.07 ukb-melanoma-latest-gwas all 272.1 Hyperlipidemia Endocrine/metabolic Both 1.01 1 1.03 0.0117 34878 235352 TRUE 1.93181413825384 0.0147 0.00582 0.0265 0.0165 0.108 1.03 0.994 1.06 0.0412 0.0165 0.0124 1.04 1.01 1.08 0.038 0.0165 0.0216 1.04 1.01 1.07 ukb-melanoma-latest-gwas all 272.9 Unspecified disorder of lipoid metabolism Endocrine/metabolic Both 1.03 0.894 1.19 0.677 211 2110 FALSE 0.169411331314856 0.03 0.072 0.0662 0.212 0.755 1.07 0.702 1.63 0.346 0.201 0.0848 1.41 0.953 2.11 0.137 0.21 0.515 1.15 0.757 1.74 ukb-melanoma-latest-gwas all 272.11 Hypercholesterolemia Endocrine/metabolic Both 1.01 1 1.03 0.0179 32352 218140 TRUE 1.74714696902011 0.0143 0.00604 0.0232 0.0171 0.176 1.02 0.99 1.06 0.0441 0.0171 0.00981 1.05 1.01 1.08 0.0347 0.0172 0.0433 1.04 1 1.07 ukb-melanoma-latest-gwas all 272.12 Hyperglyceridemia Endocrine/metabolic Both 1.08 0.824 1.42 0.569 58 580 FALSE 0.244887733604929 0.0774 0.136 -0.955 0.438 0.0292 0.385 0.149 0.896 -0.108 0.347 0.756 0.898 0.446 1.79 -0.237 0.358 0.509 0.789 0.382 1.61 ukb-melanoma-latest-gwas all 272.13 Mixed hyperlipidemia Endocrine/metabolic Both 0.906 0.771 1.06 0.224 164 1638 FALSE 0.649751981665837 -0.0991 0.0815 0.0734 0.226 0.746 1.08 0.687 1.69 0.2 0.219 0.363 1.22 0.793 1.89 -0.293 0.246 0.234 0.746 0.454 1.21 ukb-melanoma-latest-gwas all 274 Gout and other crystal arthropathies Endocrine/metabolic Both 1.02 0.985 1.05 0.271 3742 37420 FALSE 0.567030709125594 0.019 0.0172 0.025 0.0493 0.612 1.03 0.931 1.13 0.1 0.0486 0.039 1.11 1.01 1.22 0.0684 0.0491 0.164 1.07 0.972 1.18 ukb-melanoma-latest-gwas all 274.1 Gout Endocrine/metabolic Both 1.01 0.977 1.05 0.477 3176 31760 FALSE 0.321481620959886 0.0133 0.0187 0.0158 0.0535 0.768 1.02 0.915 1.13 0.0972 0.0526 0.0646 1.1 0.994 1.22 0.0595 0.0533 0.265 1.06 0.956 1.18 ukb-melanoma-latest-gwas all 274.2 Crystal arthropathies Endocrine/metabolic Both 1.05 0.966 1.14 0.246 614 6140 FALSE 0.609064892896621 0.0493 0.0425 0.0409 0.121 0.736 1.04 0.821 1.32 0.0757 0.12 0.529 1.08 0.852 1.37 0.082 0.121 0.497 1.09 0.856 1.38 ukb-melanoma-latest-gwas all 274.11 Gouty arthropathy Endocrine/metabolic Both 1.01 0.833 1.23 0.9 111 1110 FALSE 0.0457574905606751 0.0124 0.0987 -0.0775 0.276 0.779 0.925 0.533 1.6 -0.218 0.284 0.443 0.804 0.454 1.41 0.0042 0.27 0.988 1 0.588 1.72 ukb-melanoma-latest-gwas all 274.21 Chondrocalcinosis Endocrine/metabolic Both 1.06 0.969 1.15 0.209 559 5590 FALSE 0.679853713888946 0.056 0.0446 0.0611 0.128 0.632 1.06 0.827 1.37 0.099 0.127 0.434 1.1 0.861 1.42 0.124 0.126 0.326 1.13 0.883 1.45 ukb-melanoma-latest-gwas all 275 Disorders of mineral metabolism Endocrine/metabolic Both 1.03 0.981 1.07 0.255 2116 21160 FALSE 0.593459819566045 0.0261 0.0229 -0.0648 0.0656 0.323 0.937 0.824 1.07 0.0278 0.0643 0.666 1.03 0.906 1.17 0.037 0.0643 0.565 1.04 0.915 1.18 ukb-melanoma-latest-gwas all 275.1 Disorders of iron metabolism Hematopoietic Both 1.03 0.947 1.11 0.532 657 6570 FALSE 0.274088367704952 0.0257 0.0411 -0.125 0.118 0.286 0.882 0.7 1.11 0.000189 0.114 0.999 1 0.799 1.25 0.0356 0.114 0.756 1.04 0.828 1.3 ukb-melanoma-latest-gwas all 275.3 Disorders of magnesium metabolism Endocrine/metabolic Both 1.06 0.949 1.18 0.314 374 3740 FALSE 0.503070351926785 0.0548 0.0544 0.0634 0.156 0.685 1.07 0.783 1.45 0.0654 0.156 0.675 1.07 0.786 1.45 0.118 0.154 0.442 1.13 0.832 1.53 ukb-melanoma-latest-gwas all 275.5 Disorders of calcium/phosphorus metabolism Endocrine/metabolic Both 1.02 0.966 1.09 0.419 1205 12050 FALSE 0.377785977033705 0.0245 0.0304 -0.0564 0.0867 0.515 0.945 0.797 1.12 0.0336 0.0852 0.694 1.03 0.875 1.22 0.0229 0.0854 0.789 1.02 0.865 1.21 ukb-melanoma-latest-gwas all 275.53 Disorders of phosphorus metabolism Endocrine/metabolic Both 1.11 0.945 1.29 0.208 172 1720 FALSE 0.681936665037238 0.1 0.0797 -0.0224 0.235 0.924 0.978 0.612 1.56 0.23 0.225 0.308 1.26 0.807 1.97 0.216 0.226 0.339 1.24 0.795 1.95 ukb-melanoma-latest-gwas all 276 Disorders of fluid, electrolyte, and acid-base balance Endocrine/metabolic Both 1.01 0.987 1.04 0.371 7342 73420 FALSE 0.430626090384954 0.011 0.0123 0.0295 0.0348 0.396 1.03 0.962 1.1 0.0149 0.0349 0.669 1.02 0.948 1.09 0.0289 0.0349 0.408 1.03 0.961 1.1 ukb-melanoma-latest-gwas all 276.1 Electrolyte imbalance Endocrine/metabolic Both 1.03 0.995 1.06 0.103 4113 41130 FALSE 0.987162775294828 0.0268 0.0164 0.11 0.0464 0.0176 1.12 1.02 1.22 0.0385 0.0472 0.415 1.04 0.947 1.14 0.0857 0.0469 0.0678 1.09 0.994 1.19 ukb-melanoma-latest-gwas all 276.4 Acid-base balance disorder Endocrine/metabolic Both 1.01 0.952 1.07 0.716 1160 11600 FALSE 0.145086977692144 0.0113 0.031 0.164 0.0859 0.0566 1.18 0.995 1.39 -0.0919 0.0908 0.311 0.912 0.763 1.09 0.0813 0.0881 0.356 1.08 0.913 1.29 ukb-melanoma-latest-gwas all 276.5 Hypovolemia Endocrine/metabolic Both 1.01 0.972 1.05 0.59 2825 28250 FALSE 0.229147988357856 0.0107 0.0198 -0.0122 0.0563 0.828 0.988 0.885 1.1 0.0387 0.0557 0.488 1.04 0.932 1.16 -0.00583 0.0564 0.918 0.994 0.89 1.11 ukb-melanoma-latest-gwas all 276.6 Fluid overload Endocrine/metabolic Both 0.981 0.89 1.08 0.699 455 4550 FALSE 0.155522824254319 -0.0191 0.0493 -0.0185 0.137 0.893 0.982 0.749 1.29 -0.0914 0.14 0.513 0.913 0.693 1.2 -0.0247 0.139 0.859 0.976 0.742 1.28 ukb-melanoma-latest-gwas all 276.11 Hyperosmolality and/or hypernatremia Endocrine/metabolic Both 1.05 0.915 1.2 0.505 239 2390 FALSE 0.296708621881339 0.0452 0.0678 0.177 0.2 0.377 1.19 0.804 1.78 0.433 0.191 0.0231 1.54 1.06 2.26 0.135 0.204 0.509 1.14 0.765 1.71 ukb-melanoma-latest-gwas all 276.12 Hyposmolality and/or hyponatremia Endocrine/metabolic Both 1.03 0.978 1.08 0.285 1822 18220 FALSE 0.54515513999149 0.0264 0.0247 0.106 0.0691 0.124 1.11 0.971 1.27 -0.00963 0.0709 0.892 0.99 0.862 1.14 0.0528 0.0703 0.452 1.05 0.918 1.21 ukb-melanoma-latest-gwas all 276.13 Hyperpotassemia Endocrine/metabolic Both 1.06 0.992 1.13 0.0865 977 9770 FALSE 1.06298389253519 0.0578 0.0337 0.201 0.0966 0.0377 1.22 1.01 1.48 0.154 0.0975 0.114 1.17 0.964 1.41 0.172 0.0975 0.077 1.19 0.981 1.44 ukb-melanoma-latest-gwas all 276.14 Hypopotassemia Endocrine/metabolic Both 1.02 0.965 1.08 0.496 1422 14220 FALSE 0.304518323509803 0.019 0.0279 0.0164 0.0785 0.835 1.02 0.871 1.19 -0.0587 0.08 0.463 0.943 0.806 1.1 0.055 0.0781 0.481 1.06 0.906 1.23 ukb-melanoma-latest-gwas all 276.41 Acidosis Endocrine/metabolic Both 1.01 0.95 1.08 0.702 1059 10590 FALSE 0.153662887870195 0.0124 0.0324 0.194 0.09 0.0311 1.21 1.02 1.45 -0.0642 0.0951 0.5 0.938 0.778 1.13 0.0842 0.0927 0.364 1.09 0.907 1.31 ukb-melanoma-latest-gwas all 276.42 Alkalosis Endocrine/metabolic Both 0.991 0.816 1.21 0.924 112 1120 FALSE 0.0343280287798933 -0.00938 0.0985 -0.188 0.273 0.491 0.829 0.479 1.42 -0.399 0.288 0.167 0.671 0.374 1.18 0.118 0.26 0.651 1.12 0.672 1.89 ukb-melanoma-latest-gwas all 277 Other disorders of metabolism Endocrine/metabolic Both 1 0.934 1.07 0.981 905 9048 FALSE 0.0083309926200515 0.000849 0.035 0.014 0.101 0.889 1.01 0.832 1.24 0.183 0.0969 0.0585 1.2 0.993 1.45 -0.00892 0.102 0.93 0.991 0.811 1.21 ukb-melanoma-latest-gwas all 277.5 Other disorders of lipoid metabolism Endocrine/metabolic Both 1.18 0.929 1.5 0.17 75 750 FALSE 0.769551078621726 0.165 0.12 -0.642 0.392 0.101 0.526 0.23 1.14 0.361 0.316 0.253 1.44 0.77 2.73 0.177 0.327 0.589 1.19 0.622 2.31 ukb-melanoma-latest-gwas all 277.51 Lipoprotein disorders Endocrine/metabolic Both 1.19 0.892 1.58 0.233 52 520 FALSE 0.632644078973981 0.17 0.142 -0.711 0.451 0.114 0.491 0.185 1.2 0.147 0.373 0.693 1.16 0.549 2.47 0.0583 0.374 0.876 1.06 0.5 2.26 ukb-melanoma-latest-gwas all 278 Overweight, obesity and other hyperalimentation Endocrine/metabolic Both 1.01 0.995 1.04 0.146 10863 108629 FALSE 0.835647144215563 0.0147 0.0101 -0.000473 0.0287 0.987 1 0.945 1.06 0.0177 0.0286 0.536 1.02 0.962 1.08 0.0283 0.0286 0.322 1.03 0.973 1.09 ukb-melanoma-latest-gwas all 278.1 Obesity Endocrine/metabolic Both 1.02 0.996 1.04 0.117 10696 106959 FALSE 0.931814138253838 0.016 0.0102 -0.00191 0.0289 0.947 0.998 0.943 1.06 0.0138 0.0288 0.633 1.01 0.958 1.07 0.0321 0.0288 0.264 1.03 0.976 1.09 ukb-melanoma-latest-gwas all 278.3 Localized adiposity Endocrine/metabolic Both 0.997 0.795 1.25 0.978 83 830 FALSE 0.00966114521239857 -0.00309 0.114 0.61 0.333 0.0672 1.84 0.959 3.67 0.712 0.334 0.0329 2.04 1.06 4.07 -0.0117 0.38 0.975 0.988 0.454 2.14 ukb-melanoma-latest-gwas all 278.4 Abnormal weight gain Endocrine/metabolic Both 1.04 0.81 1.34 0.736 66 660 FALSE 0.133122185662501 0.0428 0.127 -0.192 0.367 0.6 0.825 0.391 1.72 -0.0982 0.366 0.789 0.906 0.433 1.89 0.124 0.342 0.718 1.13 0.571 2.26 ukb-melanoma-latest-gwas all 279 Disorders involving the immune mechanism Endocrine/metabolic Both 0.982 0.862 1.12 0.783 252 2520 FALSE 0.106238237942057 -0.0183 0.0663 -0.388 0.188 0.039 0.679 0.467 0.98 -0.216 0.179 0.228 0.806 0.564 1.15 -0.161 0.18 0.373 0.852 0.596 1.21 ukb-melanoma-latest-gwas all 279.1 Immunity deficiency Endocrine/metabolic Both 1 0.869 1.16 0.975 211 2110 FALSE 0.0109953843014632 0.00228 0.0723 -0.399 0.208 0.0552 0.671 0.442 1.01 -0.141 0.195 0.469 0.868 0.59 1.27 -0.106 0.197 0.588 0.899 0.608 1.32 ukb-melanoma-latest-gwas all 279.11 Deficiency of humoral immunity Endocrine/metabolic Both 0.924 0.775 1.1 0.374 140 1400 FALSE 0.42712839779952 -0.0788 0.0887 -0.365 0.247 0.139 0.694 0.423 1.13 -0.094 0.232 0.685 0.91 0.574 1.44 -0.41 0.255 0.108 0.664 0.396 1.09 ukb-melanoma-latest-gwas all 280 Iron deficiency anemias Hematopoietic Both 1.04 1.01 1.06 0.00292 7750 77478 TRUE 2.53461714855158 0.0356 0.012 -0.004 0.0342 0.907 0.996 0.931 1.07 0.0434 0.0339 0.201 1.04 0.977 1.12 0.0813 0.0338 0.0161 1.08 1.02 1.16 ukb-melanoma-latest-gwas all 280.1 Iron deficiency anemias, unspecified or not due to blood loss Hematopoietic Both 1.03 1.01 1.06 0.00525 7378 73758 TRUE 2.27984069659404 0.0343 0.0123 0.00764 0.0351 0.828 1.01 0.941 1.08 0.0471 0.0348 0.176 1.05 0.979 1.12 0.0819 0.0347 0.0181 1.09 1.01 1.16 ukb-melanoma-latest-gwas all 280.2 Iron deficiency anemia secondary to blood loss (chronic) Hematopoietic Both 1.12 1.01 1.23 0.0235 455 4550 TRUE 1.62893213772826 0.111 0.0492 -0.261 0.149 0.0791 0.77 0.574 1.03 0.105 0.137 0.443 1.11 0.849 1.45 0.165 0.135 0.222 1.18 0.905 1.54 ukb-melanoma-latest-gwas all 281 Other deficiency anemia Hematopoietic Both 1.05 0.992 1.12 0.0912 1131 11310 FALSE 1.04000516167158 0.0529 0.0313 0.0349 0.0905 0.699 1.04 0.867 1.24 0.145 0.0886 0.101 1.16 0.972 1.38 0.113 0.0894 0.205 1.12 0.94 1.34 ukb-melanoma-latest-gwas all 281.1 Megaloblastic anemia Hematopoietic Both 1.06 0.996 1.13 0.0648 1074 10740 FALSE 1.18842499412941 0.0594 0.0322 0.033 0.0928 0.722 1.03 0.861 1.24 0.129 0.0912 0.156 1.14 0.952 1.36 0.127 0.0914 0.166 1.13 0.949 1.36 ukb-melanoma-latest-gwas all 281.9 Deficiency anemias Hematopoietic Both 0.929 0.703 1.23 0.6 54 540 FALSE 0.221848749616356 -0.0733 0.14 0.127 0.403 0.753 1.14 0.503 2.59 0.433 0.375 0.248 1.54 0.737 3.34 -0.109 0.424 0.797 0.897 0.373 2.12 ukb-melanoma-latest-gwas all 281.11 Pernicious anemia Hematopoietic Both 1.08 1 1.17 0.044 752 7520 TRUE 1.35654732351381 0.0773 0.0384 0.0232 0.112 0.836 1.02 0.822 1.27 0.135 0.109 0.215 1.14 0.924 1.42 0.163 0.109 0.132 1.18 0.952 1.46 ukb-melanoma-latest-gwas all 281.12 Other vitamin B12 deficiency anemia Hematopoietic Both 1.06 0.911 1.24 0.428 178 1780 FALSE 0.368556230986828 0.0624 0.0788 0.0769 0.225 0.733 1.08 0.691 1.69 0.213 0.222 0.336 1.24 0.799 1.93 0.106 0.227 0.643 1.11 0.709 1.75 ukb-melanoma-latest-gwas all 281.13 Folate-deficiency anemia Hematopoietic Both 0.956 0.821 1.11 0.557 186 1860 FALSE 0.254144804826271 -0.0451 0.0769 -0.00244 0.208 0.991 0.998 0.66 1.51 -0.139 0.215 0.517 0.87 0.567 1.33 -0.165 0.218 0.448 0.848 0.549 1.3 ukb-melanoma-latest-gwas all 282 Hereditary hemolytic anemias Hematopoietic Both 1.05 0.887 1.23 0.597 157 1570 FALSE 0.224025668870631 0.0442 0.0834 0.176 0.238 0.461 1.19 0.744 1.92 0.211 0.238 0.375 1.23 0.772 1.99 0.184 0.243 0.449 1.2 0.744 1.95 ukb-melanoma-latest-gwas all 282.8 Other hemoglobinopathies Hematopoietic Both 0.963 0.732 1.27 0.782 56 560 FALSE 0.106793246940152 -0.0381 0.138 -0.106 0.39 0.785 0.899 0.406 1.97 0.191 0.368 0.604 1.21 0.581 2.56 -0.0795 0.398 0.842 0.924 0.41 2.06 ukb-melanoma-latest-gwas all 282.9 Other hereditary hemolytic anemias Hematopoietic Both 1.09 0.872 1.36 0.443 85 850 FALSE 0.35359627377693 0.0861 0.112 0.336 0.321 0.295 1.4 0.742 2.69 0.128 0.334 0.701 1.14 0.583 2.24 0.369 0.325 0.256 1.45 0.76 2.8 ukb-melanoma-latest-gwas all 283 Acquired hemolytic anemias Hematopoietic Both 0.991 0.834 1.18 0.922 143 1430 FALSE 0.0352690789463706 -0.00858 0.0874 -0.115 0.252 0.647 0.891 0.538 1.47 0.26 0.233 0.264 1.3 0.82 2.07 -0.16 0.257 0.532 0.852 0.509 1.42 ukb-melanoma-latest-gwas all 283.1 Autoimmune hemolytic anemias Hematopoietic Both 1.01 0.83 1.24 0.898 107 1070 FALSE 0.0467236633326956 0.0129 0.101 -0.0216 0.295 0.942 0.979 0.541 1.77 0.379 0.271 0.163 1.46 0.857 2.52 -0.0694 0.298 0.816 0.933 0.513 1.69 ukb-melanoma-latest-gwas all 284 Aplastic anemia Hematopoietic Both 1.03 0.936 1.14 0.518 440 4400 FALSE 0.285670240254767 0.0323 0.05 -0.123 0.145 0.397 0.884 0.664 1.18 0.146 0.137 0.289 1.16 0.883 1.52 0.00164 0.142 0.991 1 0.758 1.32 ukb-melanoma-latest-gwas all 285 Other anemias Hematopoietic Both 1.03 1.01 1.05 0.000611 12138 121369 TRUE 3.21395878975745 0.0328 0.00957 0.0518 0.0273 0.0578 1.05 0.998 1.11 0.0715 0.0272 0.00864 1.07 1.02 1.13 0.0828 0.0272 0.00235 1.09 1.03 1.15 ukb-melanoma-latest-gwas all 285.1 Acute posthemorrhagic anemia Hematopoietic Both 0.924 0.816 1.05 0.216 269 2690 FALSE 0.665546248849069 -0.0785 0.0635 0.00254 0.173 0.988 1 0.713 1.41 -0.286 0.186 0.124 0.751 0.519 1.08 -0.0697 0.176 0.692 0.933 0.659 1.32 ukb-melanoma-latest-gwas all 285.2 Anemia of chronic disease Hematopoietic Both 1.03 0.948 1.11 0.528 693 6930 FALSE 0.277366077466188 0.0253 0.0401 0.122 0.114 0.286 1.13 0.903 1.41 0.155 0.114 0.174 1.17 0.934 1.46 0.0914 0.117 0.433 1.1 0.872 1.38 ukb-melanoma-latest-gwas all 285.22 Anemia in neoplastic disease Hematopoietic Both 1.06 0.959 1.18 0.249 412 4120 FALSE 0.603800652904264 0.0601 0.0521 0.112 0.148 0.449 1.12 0.836 1.5 0.0861 0.15 0.565 1.09 0.812 1.46 0.191 0.149 0.2 1.21 0.904 1.62 ukb-melanoma-latest-gwas all 286 Coagulation defects Hematopoietic Both 1.03 0.962 1.1 0.399 929 9290 FALSE 0.399027104313252 0.0291 0.0345 -0.13 0.0984 0.185 0.878 0.723 1.06 -0.000225 0.0959 0.998 1 0.828 1.21 -0.0149 0.0965 0.877 0.985 0.815 1.19 ukb-melanoma-latest-gwas all 286.1 Congenital coagulation defects Hematopoietic Both 1.03 0.935 1.13 0.547 460 4600 FALSE 0.262012673666569 0.0296 0.0491 -0.166 0.139 0.233 0.847 0.644 1.11 -0.101 0.138 0.463 0.904 0.689 1.18 -0.0128 0.135 0.925 0.987 0.757 1.29 ukb-melanoma-latest-gwas all 286.5 Hemorrhagic disorder due to intrinsic circulating anticoagulants Hematopoietic Both 0.982 0.786 1.23 0.869 85 850 FALSE 0.0609802235513335 -0.0185 0.112 0.0184 0.316 0.954 1.02 0.54 1.92 0.17 0.308 0.582 1.18 0.643 2.2 -0.0711 0.323 0.826 0.931 0.485 1.78 ukb-melanoma-latest-gwas all 286.7 Other and unspecified coagulation defects Hematopoietic Both 1.06 0.953 1.18 0.289 387 3870 FALSE 0.539102157243452 0.0566 0.0533 -0.0481 0.156 0.758 0.953 0.701 1.3 0.191 0.148 0.197 1.21 0.905 1.62 0.0968 0.152 0.524 1.1 0.817 1.49 ukb-melanoma-latest-gwas all 286.11 Von willebrand's disease Hematopoietic Both 0.953 0.773 1.18 0.653 96 960 FALSE 0.185086818724926 -0.0479 0.106 0.158 0.3 0.598 1.17 0.644 2.14 0.0765 0.304 0.801 1.08 0.588 1.99 0.077 0.307 0.802 1.08 0.584 2 ukb-melanoma-latest-gwas all 286.12 Congenital deficiency of other clotting factors (including factor VII) Hematopoietic Both 1.04 0.92 1.17 0.551 294 2940 FALSE 0.258848401148215 0.0365 0.0613 -0.36 0.174 0.0382 0.697 0.493 0.98 -0.26 0.171 0.127 0.771 0.549 1.08 -0.103 0.164 0.528 0.902 0.652 1.24 ukb-melanoma-latest-gwas all 286.13 Congenital factor VIII disorder Hematopoietic Both 1.36 1.05 1.78 0.0209 63 630 TRUE 1.67985371388895 0.309 0.134 0.291 0.403 0.47 1.34 0.594 3.11 0.503 0.395 0.204 1.65 0.755 3.79 0.775 0.383 0.0429 2.17 1.03 4.86 ukb-melanoma-latest-gwas all 287 Purpura and other hemorrhagic conditions Hematopoietic Both 0.994 0.945 1.05 0.811 1684 16840 FALSE 0.0909791457888439 -0.00614 0.0257 0.0495 0.072 0.492 1.05 0.912 1.21 0.0288 0.0725 0.691 1.03 0.893 1.19 -0.0246 0.0735 0.738 0.976 0.845 1.13 ukb-melanoma-latest-gwas all 287.2 Allergic purpura Hematopoietic Both 0.925 0.694 1.24 0.587 51 510 FALSE 0.231361898752386 -0.0783 0.144 -0.0207 0.39 0.958 0.979 0.444 2.15 0.0217 0.389 0.956 1.02 0.467 2.24 -0.342 0.42 0.415 0.71 0.296 1.65 ukb-melanoma-latest-gwas all 287.3 Thrombocytopenia Hematopoietic Both 0.995 0.945 1.05 0.859 1566 15660 FALSE 0.0660068361687577 -0.00471 0.0266 0.0324 0.0746 0.664 1.03 0.892 1.2 0.00221 0.0752 0.977 1 0.865 1.16 -0.0261 0.0758 0.73 0.974 0.839 1.13 ukb-melanoma-latest-gwas all 287.31 Primary thrombocytopenia Hematopoietic Both 1.06 0.961 1.18 0.232 421 4210 FALSE 0.6345120151091 0.0615 0.0514 0.234 0.146 0.11 1.26 0.948 1.69 0.0385 0.152 0.8 1.04 0.77 1.4 0.257 0.146 0.0777 1.29 0.972 1.73 ukb-melanoma-latest-gwas all 287.32 Secondary thrombocytopenia Hematopoietic Both 1.04 0.823 1.33 0.717 75 750 FALSE 0.1444808443322 0.0434 0.12 0.148 0.336 0.66 1.16 0.593 2.29 0.0858 0.346 0.804 1.09 0.544 2.19 0.179 0.34 0.598 1.2 0.607 2.38 ukb-melanoma-latest-gwas all 288 Diseases of white blood cells Hematopoietic Both 0.986 0.953 1.02 0.404 3795 37950 FALSE 0.393618634889395 -0.0143 0.0171 -0.012 0.0482 0.803 0.988 0.899 1.09 0.0128 0.0479 0.79 1.01 0.922 1.11 -0.03 0.0486 0.537 0.97 0.882 1.07 ukb-melanoma-latest-gwas all 288.1 Decreased white blood cell count Hematopoietic Both 0.976 0.941 1.01 0.193 3192 31920 FALSE 0.714442690992226 -0.0243 0.0186 -0.0298 0.0523 0.569 0.971 0.876 1.08 0.00165 0.052 0.975 1 0.905 1.11 -0.0701 0.0531 0.187 0.932 0.84 1.03 ukb-melanoma-latest-gwas all 288.3 Eosinophilia Hematopoietic Both 1.09 0.856 1.4 0.469 71 710 FALSE 0.328827157284917 0.0895 0.124 0.612 0.357 0.0866 1.84 0.915 3.89 0.318 0.389 0.414 1.37 0.63 3.07 0.436 0.369 0.237 1.55 0.745 3.33 ukb-melanoma-latest-gwas all 288.11 Neutropenia Hematopoietic Both 0.976 0.941 1.01 0.193 3192 31920 FALSE 0.714442690992226 -0.0243 0.0186 -0.0298 0.0523 0.569 0.971 0.876 1.08 0.00165 0.052 0.975 1 0.905 1.11 -0.0701 0.0531 0.187 0.932 0.84 1.03 ukb-melanoma-latest-gwas all 289 Other diseases of blood and blood-forming organs Hematopoietic Both 1.03 0.962 1.11 0.387 868 8680 FALSE 0.412289034981089 0.0309 0.0357 0.145 0.103 0.157 1.16 0.945 1.41 0.18 0.102 0.0763 1.2 0.981 1.46 0.0967 0.104 0.352 1.1 0.898 1.35 ukb-melanoma-latest-gwas all 289.3 Personal history of diseases of blood and blood-forming organs Hematopoietic Both 1.02 0.904 1.15 0.752 291 2910 FALSE 0.123782159408358 0.0194 0.0615 0.344 0.178 0.0533 1.41 0.995 2.01 0.287 0.179 0.11 1.33 0.937 1.9 0.181 0.184 0.326 1.2 0.834 1.73 ukb-melanoma-latest-gwas all 289.9 Abnormality of red blood cells Hematopoietic Both 1.1 0.883 1.36 0.394 90 900 FALSE 0.404503778174426 0.0933 0.11 0.247 0.319 0.438 1.28 0.679 2.45 0.265 0.326 0.415 1.3 0.682 2.52 0.356 0.312 0.253 1.43 0.772 2.69 ukb-melanoma-latest-gwas all 290 Delirium dementia and amnestic and other cognitive disorders Mental Disorders Both 1.05 0.998 1.1 0.0599 1949 19490 FALSE 1.22257317761069 0.0449 0.0239 0.0742 0.0674 0.271 1.08 0.944 1.23 0.0353 0.0681 0.604 1.04 0.906 1.18 0.0449 0.0682 0.51 1.05 0.915 1.2 ukb-melanoma-latest-gwas all 290.1 Dementias Mental Disorders Both 1.05 0.987 1.12 0.118 1006 10060 FALSE 0.928117992693875 0.052 0.0332 0.278 0.0942 0.00318 1.32 1.1 1.59 0.103 0.098 0.291 1.11 0.915 1.34 0.173 0.0966 0.074 1.19 0.983 1.44 ukb-melanoma-latest-gwas all 290.2 Delirium due to conditions classified elsewhere Mental Disorders Both 1.03 0.946 1.11 0.54 651 6510 FALSE 0.267606240177031 0.0253 0.0413 -0.00726 0.115 0.95 0.993 0.791 1.25 0.00381 0.115 0.974 1 0.8 1.26 -0.0877 0.118 0.457 0.916 0.726 1.15 ukb-melanoma-latest-gwas all 290.11 Alzheimer's disease Mental Disorders Both 1.11 1 1.22 0.0419 433 4330 TRUE 1.3777859770337 0.103 0.0507 0.246 0.147 0.094 1.28 0.959 1.71 0.2 0.149 0.18 1.22 0.911 1.64 0.303 0.146 0.0376 1.35 1.02 1.81 ukb-melanoma-latest-gwas all 290.16 Vascular dementia Mental Disorders Both 1.03 0.89 1.19 0.683 201 2010 FALSE 0.165579296318467 0.0303 0.0742 0.249 0.203 0.218 1.28 0.862 1.92 0.0299 0.212 0.888 1.03 0.677 1.57 -0.0513 0.219 0.815 0.95 0.615 1.47 ukb-melanoma-latest-gwas all 291 Other specified nonpsychotic and/or transient mental disorders Mental Disorders Both 1.08 0.997 1.17 0.0583 638 6380 FALSE 1.23433144524099 0.0791 0.0418 0.216 0.123 0.0788 1.24 0.975 1.58 0.364 0.12 0.0024 1.44 1.14 1.82 0.233 0.124 0.0593 1.26 0.991 1.61 ukb-melanoma-latest-gwas all 291.1 Transient mental disorders due to conditions classified elsewhere Mental Disorders Both 0.948 0.786 1.14 0.572 121 1210 FALSE 0.242603971206976 -0.0536 0.0948 -0.106 0.268 0.693 0.9 0.527 1.53 -0.00146 0.262 0.996 0.999 0.592 1.68 -0.0363 0.267 0.892 0.964 0.565 1.64 ukb-melanoma-latest-gwas all 291.4 Specific nonpsychotic mental disorders due to brain damage Mental Disorders Both 1.09 0.873 1.36 0.431 85 850 FALSE 0.365522729839268 0.0886 0.113 -0.209 0.334 0.531 0.812 0.412 1.58 0.162 0.313 0.605 1.18 0.632 2.21 0.169 0.314 0.59 1.18 0.634 2.23 ukb-melanoma-latest-gwas all 291.8 Alteration of consciousness Mental Disorders Both 1.11 1.01 1.23 0.0313 437 4370 TRUE 1.50445566245355 0.109 0.0505 0.405 0.152 0.00748 1.5 1.12 2.03 0.545 0.148 0.000239 1.72 1.29 2.32 0.323 0.154 0.0366 1.38 1.02 1.88 ukb-melanoma-latest-gwas all 292 Neurological disorders Mental Disorders Both 1.02 0.989 1.05 0.217 4645 46450 FALSE 0.66354026615147 0.0191 0.0155 0.037 0.0437 0.397 1.04 0.952 1.13 0.0132 0.044 0.764 1.01 0.93 1.1 0.0491 0.0438 0.263 1.05 0.964 1.14 ukb-melanoma-latest-gwas all 292.1 Aphasia/speech disturbance Mental Disorders Both 1.02 0.967 1.08 0.466 1507 15070 FALSE 0.33161408331 0.0198 0.0271 0.115 0.077 0.134 1.12 0.965 1.31 0.102 0.0772 0.188 1.11 0.951 1.29 0.0647 0.0782 0.408 1.07 0.915 1.24 ukb-melanoma-latest-gwas all 292.2 Mild cognitive impairment Mental Disorders Both 0.972 0.837 1.13 0.706 190 1900 FALSE 0.151195298948196 -0.0287 0.0759 -0.321 0.21 0.127 0.726 0.477 1.1 -0.294 0.209 0.159 0.745 0.491 1.12 -0.208 0.206 0.312 0.812 0.539 1.22 ukb-melanoma-latest-gwas all 292.3 Memory loss Mental Disorders Both 1.06 0.979 1.14 0.154 700 7000 FALSE 0.812479279163537 0.0568 0.0398 -0.113 0.116 0.331 0.893 0.71 1.12 0.089 0.111 0.422 1.09 0.879 1.36 0.109 0.111 0.328 1.11 0.896 1.39 ukb-melanoma-latest-gwas all 292.4 Altered mental status Mental Disorders Both 1 0.961 1.05 0.83 2185 21850 FALSE 0.0809219076239261 0.00485 0.0225 0.0506 0.0632 0.423 1.05 0.929 1.19 -0.0134 0.0642 0.835 0.987 0.87 1.12 0.00822 0.064 0.898 1.01 0.889 1.14 ukb-melanoma-latest-gwas all 292.6 Hallucinations Mental Disorders Both 1.05 0.935 1.18 0.403 308 3080 FALSE 0.394694953858891 0.0501 0.0599 0.235 0.169 0.163 1.27 0.908 1.77 0.114 0.175 0.512 1.12 0.795 1.58 0.138 0.173 0.427 1.15 0.816 1.62 ukb-melanoma-latest-gwas all 293 Symptoms involving head and neck Mental Disorders Both 1.02 0.975 1.07 0.393 2082 20820 FALSE 0.405607449624573 0.0197 0.0231 -0.0127 0.0653 0.845 0.987 0.869 1.12 -0.0699 0.0662 0.291 0.932 0.819 1.06 0.0839 0.0644 0.193 1.09 0.959 1.23 ukb-melanoma-latest-gwas all 295 Schizophrenia and other psychotic disorders Mental Disorders Both 0.994 0.926 1.07 0.858 851 8510 FALSE 0.0665127121512946 -0.00647 0.0361 -0.0115 0.103 0.911 0.989 0.808 1.21 0.116 0.1 0.248 1.12 0.922 1.37 -0.014 0.104 0.892 0.986 0.804 1.21 ukb-melanoma-latest-gwas all 295.1 Schizophrenia Mental Disorders Both 0.977 0.896 1.07 0.597 572 5720 FALSE 0.224025668870631 -0.0232 0.0439 0.00508 0.124 0.967 1.01 0.788 1.28 0.0437 0.123 0.723 1.04 0.82 1.33 -0.00446 0.125 0.972 0.996 0.778 1.27 ukb-melanoma-latest-gwas all 295.2 Paranoid disorders Mental Disorders Both 1.04 0.895 1.22 0.579 179 1790 FALSE 0.237321436272564 0.0434 0.0781 0.173 0.225 0.441 1.19 0.763 1.86 0.288 0.219 0.189 1.33 0.866 2.07 0.0266 0.231 0.908 1.03 0.649 1.63 ukb-melanoma-latest-gwas all 295.3 Psychosis Mental Disorders Both 0.903 0.77 1.06 0.205 171 1710 FALSE 0.688246138944246 -0.102 0.0805 -0.113 0.224 0.613 0.893 0.571 1.39 -0.015 0.221 0.946 0.985 0.635 1.53 -0.144 0.228 0.526 0.866 0.55 1.36 ukb-melanoma-latest-gwas all 296 Mood disorders Mental Disorders Both 1.01 0.991 1.03 0.339 12461 124609 FALSE 0.469800301796918 0.00902 0.00944 -0.00538 0.0266 0.84 0.995 0.944 1.05 -0.0124 0.0267 0.641 0.988 0.937 1.04 0.00608 0.0267 0.82 1.01 0.955 1.06 ukb-melanoma-latest-gwas all 296.1 Bipolar Mental Disorders Both 1.02 0.953 1.08 0.645 1058 10580 FALSE 0.190440285364732 0.0149 0.0324 -0.151 0.093 0.104 0.86 0.716 1.03 -0.0628 0.0912 0.491 0.939 0.785 1.12 0.0628 0.089 0.48 1.06 0.894 1.27 ukb-melanoma-latest-gwas all 296.2 Depression Mental Disorders Both 1.01 0.988 1.03 0.449 11805 118049 FALSE 0.347753658996677 0.00734 0.0097 0.00577 0.0273 0.833 1.01 0.953 1.06 -0.00725 0.0274 0.791 0.993 0.941 1.05 -0.00136 0.0275 0.961 0.999 0.946 1.05 ukb-melanoma-latest-gwas all 296.22 Major depressive disorder Mental Disorders Both 1.03 0.924 1.15 0.592 361 3610 FALSE 0.22767829327708 0.0296 0.0553 0.15 0.157 0.34 1.16 0.853 1.59 0.141 0.158 0.372 1.15 0.844 1.57 0.103 0.16 0.52 1.11 0.809 1.52 ukb-melanoma-latest-gwas all 297 Suicidal ideation or attempt Mental Disorders Both 0.917 0.821 1.03 0.127 343 3391 FALSE 0.896196279044043 -0.0863 0.0566 0.00919 0.15 0.951 1.01 0.751 1.36 -0.392 0.166 0.0177 0.675 0.486 0.934 -0.201 0.159 0.204 0.818 0.597 1.12 ukb-melanoma-latest-gwas all 297.2 Suicide or self-inflicted injury Mental Disorders Both 0.917 0.816 1.03 0.138 319 3161 FALSE 0.860120913598763 -0.0872 0.0588 0.0316 0.156 0.839 1.03 0.76 1.4 -0.391 0.172 0.0232 0.676 0.48 0.948 -0.177 0.165 0.282 0.838 0.604 1.16 ukb-melanoma-latest-gwas all 300 Anxiety disorders Mental Disorders Both 1 0.978 1.03 0.832 6904 69029 FALSE 0.0798766737092761 0.00269 0.0127 -0.0311 0.0359 0.387 0.969 0.904 1.04 -0.00383 0.0357 0.914 0.996 0.929 1.07 0.00453 0.0358 0.899 1 0.936 1.08 ukb-melanoma-latest-gwas all 300.1 Anxiety disorder Mental Disorders Both 1 0.976 1.03 0.875 6341 63399 FALSE 0.0579919469776868 0.00207 0.0132 -0.026 0.0374 0.486 0.974 0.905 1.05 -0.00394 0.0372 0.916 0.996 0.926 1.07 -0.00365 0.0374 0.922 0.996 0.926 1.07 ukb-melanoma-latest-gwas all 300.3 Obsessive-compulsive disorders Mental Disorders Both 1.03 0.868 1.23 0.705 140 1400 FALSE 0.151810883008601 0.0335 0.0887 0.124 0.254 0.626 1.13 0.684 1.88 0.195 0.252 0.439 1.22 0.738 2.02 0.18 0.254 0.478 1.2 0.724 1.99 ukb-melanoma-latest-gwas all 300.4 Dysthymic disorder Mental Disorders Both 1.14 0.861 1.52 0.353 53 530 FALSE 0.452225294612177 0.131 0.142 -0.218 0.437 0.618 0.804 0.325 1.94 0.11 0.398 0.783 1.12 0.498 2.52 0.337 0.38 0.376 1.4 0.657 3.07 ukb-melanoma-latest-gwas all 300.8 Acute reaction to stress Mental Disorders Both 1.1 0.915 1.32 0.306 125 1250 FALSE 0.51427857351842 0.0953 0.0931 0.0533 0.274 0.846 1.05 0.611 1.83 0.245 0.264 0.355 1.28 0.758 2.17 0.214 0.265 0.42 1.24 0.733 2.11 ukb-melanoma-latest-gwas all 300.9 Posttraumatic stress disorder Mental Disorders Both 0.977 0.804 1.19 0.81 113 1130 FALSE 0.0915149811213502 -0.0236 0.0982 0.194 0.275 0.481 1.21 0.704 2.11 0.182 0.278 0.514 1.2 0.691 2.1 0.0538 0.291 0.853 1.06 0.591 1.89 ukb-melanoma-latest-gwas all 300.11 Generalized anxiety disorder Mental Disorders Both 0.984 0.832 1.16 0.845 150 1500 FALSE 0.0731432910503077 -0.0166 0.0849 -0.381 0.247 0.123 0.683 0.415 1.11 -0.0849 0.23 0.712 0.919 0.582 1.45 -0.0803 0.232 0.729 0.923 0.582 1.46 ukb-melanoma-latest-gwas all 300.12 Agorophobia, social phobia, and panic disorder Mental Disorders Both 0.976 0.903 1.06 0.54 704 7040 FALSE 0.267606240177031 -0.0243 0.0396 -0.0701 0.11 0.525 0.932 0.75 1.16 -0.156 0.113 0.166 0.856 0.685 1.07 -0.034 0.11 0.758 0.967 0.778 1.2 ukb-melanoma-latest-gwas all 300.13 Phobia Mental Disorders Both 1.02 0.93 1.12 0.673 497 4970 FALSE 0.171984935776023 0.0199 0.0472 -0.078 0.133 0.557 0.925 0.712 1.2 -0.164 0.136 0.226 0.849 0.649 1.11 0.0566 0.129 0.662 1.06 0.821 1.37 ukb-melanoma-latest-gwas all 301 Personality disorders Mental Disorders Both 1.1 0.986 1.23 0.0864 337 3366 FALSE 1.06348625752111 0.0981 0.0572 -0.314 0.166 0.0586 0.73 0.525 1.01 -0.239 0.164 0.143 0.787 0.569 1.09 0.134 0.151 0.376 1.14 0.85 1.54 ukb-melanoma-latest-gwas all 301.2 Antisocial/borderline personality disorder Mental Disorders Both 0.988 0.817 1.19 0.901 119 1186 FALSE 0.045275209020937 -0.0119 0.0957 -0.226 0.268 0.399 0.797 0.466 1.36 -0.263 0.273 0.335 0.769 0.444 1.32 -0.0332 0.26 0.898 0.967 0.576 1.62 ukb-melanoma-latest-gwas all 302 Sexual and gender identity disorders Mental Disorders Both 1.05 0.939 1.18 0.372 322 3220 FALSE 0.429457060118102 0.0522 0.0585 0.0498 0.173 0.773 1.05 0.748 1.48 0.255 0.167 0.126 1.29 0.931 1.8 0.199 0.168 0.235 1.22 0.878 1.7 ukb-melanoma-latest-gwas all 303 Psychogenic and somatoform disorders Mental Disorders Both 1.08 0.983 1.18 0.11 489 4890 FALSE 0.958607314841775 0.0759 0.0475 0.208 0.135 0.122 1.23 0.946 1.61 0.132 0.139 0.339 1.14 0.869 1.5 0.139 0.137 0.31 1.15 0.878 1.51 ukb-melanoma-latest-gwas all 303.3 Psychogenic disorder Mental Disorders Both 1.06 0.946 1.18 0.33 354 3540 FALSE 0.481486060122112 0.0543 0.0558 0.265 0.158 0.093 1.3 0.957 1.78 0.25 0.161 0.119 1.28 0.937 1.77 0.0396 0.166 0.811 1.04 0.75 1.44 ukb-melanoma-latest-gwas all 303.4 Somatoform disorder Mental Disorders Both 1.15 0.957 1.39 0.133 124 1240 FALSE 0.876148359032914 0.141 0.0941 0.0106 0.264 0.968 1.01 0.597 1.71 -0.295 0.287 0.305 0.745 0.416 1.32 0.348 0.252 0.168 1.42 0.862 2.35 ukb-melanoma-latest-gwas all 304 Adjustment reaction Mental Disorders Both 1.05 0.934 1.19 0.394 295 2950 FALSE 0.404503778174426 0.0521 0.061 0.155 0.178 0.386 1.17 0.822 1.66 0.29 0.174 0.095 1.34 0.951 1.89 0.168 0.178 0.346 1.18 0.833 1.68 ukb-melanoma-latest-gwas all 306 Other mental disorder Mental Disorders Both 1.02 1 1.03 0.00723 28125 230574 TRUE 2.14086170270547 0.0171 0.00636 0.0035 0.0181 0.847 1 0.968 1.04 0.053 0.0179 0.00312 1.05 1.02 1.09 0.0316 0.0181 0.0807 1.03 0.996 1.07 ukb-melanoma-latest-gwas all 306.9 Tension headache Mental Disorders Both 1.05 0.935 1.18 0.406 315 3150 FALSE 0.391473966422806 0.049 0.059 0.124 0.172 0.471 1.13 0.807 1.59 0.203 0.17 0.232 1.22 0.878 1.72 0.225 0.169 0.184 1.25 0.898 1.75 ukb-melanoma-latest-gwas all 313 Pervasive developmental disorders Mental Disorders Both 0.931 0.736 1.18 0.543 77 770 FALSE 0.265200170411153 -0.0719 0.118 -0.33 0.341 0.334 0.719 0.358 1.42 0.0543 0.318 0.864 1.06 0.56 2 -0.0695 0.33 0.833 0.933 0.48 1.81 ukb-melanoma-latest-gwas all 313.3 Autism Mental Disorders Both 0.962 0.726 1.28 0.782 54 540 FALSE 0.106793246940152 -0.039 0.141 -0.463 0.414 0.264 0.63 0.263 1.43 0.123 0.373 0.741 1.13 0.536 2.4 -0.0183 0.388 0.962 0.982 0.448 2.15 ukb-melanoma-latest-gwas all 315 Develomental delays and disorders Mental Disorders Both 0.931 0.834 1.04 0.198 353 3530 FALSE 0.703334809738469 -0.0719 0.0558 -0.11 0.15 0.463 0.896 0.667 1.2 -0.331 0.158 0.037 0.718 0.524 0.98 -0.252 0.156 0.105 0.777 0.571 1.05 ukb-melanoma-latest-gwas all 315.2 Speech and language disorder Mental Disorders Both 0.98 0.787 1.22 0.857 89 890 FALSE 0.0670191780768018 -0.0199 0.11 -0.071 0.306 0.817 0.931 0.504 1.72 0.0462 0.3 0.877 1.05 0.576 1.91 -0.248 0.321 0.44 0.78 0.407 1.48 ukb-melanoma-latest-gwas all 316 Substance addiction and disorders Mental Disorders Both 0.943 0.85 1.05 0.264 395 3950 FALSE 0.578396073130169 -0.0589 0.0528 -0.0726 0.147 0.622 0.93 0.695 1.24 -0.0254 0.146 0.862 0.975 0.731 1.3 -0.152 0.15 0.311 0.859 0.638 1.15 ukb-melanoma-latest-gwas all 316.1 Polyneuropathy due to drugs Mental Disorders Both 1.11 0.854 1.46 0.417 60 600 FALSE 0.379863945026242 0.109 0.134 -0.25 0.391 0.522 0.779 0.349 1.7 0.112 0.359 0.755 1.12 0.545 2.32 0.0712 0.366 0.846 1.07 0.514 2.25 ukb-melanoma-latest-gwas all 317 Alcohol-related disorders Mental Disorders Both 1.03 1.01 1.05 0.00402 12829 128124 TRUE 2.39577394691553 0.0268 0.00931 0.00227 0.0266 0.932 1 0.951 1.06 0.0567 0.0263 0.0311 1.06 1.01 1.11 0.0566 0.0264 0.032 1.06 1 1.11 ukb-melanoma-latest-gwas all 317.1 Alcoholism Mental Disorders Both 1.02 1 1.05 0.0402 8924 89210 TRUE 1.39577394691553 0.0229 0.0112 -0.0118 0.0318 0.712 0.988 0.929 1.05 0.0444 0.0315 0.158 1.05 0.983 1.11 0.0427 0.0316 0.177 1.04 0.981 1.11 ukb-melanoma-latest-gwas all 317.11 Alcoholic liver damage Mental Disorders Both 1.05 0.979 1.13 0.168 842 8420 FALSE 0.774690718274137 0.0501 0.0363 -0.0824 0.104 0.43 0.921 0.75 1.13 0.0215 0.102 0.833 1.02 0.836 1.25 0.0816 0.102 0.422 1.08 0.889 1.32 ukb-melanoma-latest-gwas all 318 Tobacco use disorder Mental Disorders Both 1.02 1.01 1.04 0.0083 19447 185990 TRUE 2.08092190762393 0.02 0.00758 0.0187 0.0215 0.384 1.02 0.977 1.06 0.0253 0.0215 0.24 1.03 0.983 1.07 0.051 0.0215 0.0176 1.05 1.01 1.1 ukb-melanoma-latest-gwas all 320 Meningitis Neurological Both 1 0.91 1.11 0.941 448 4480 FALSE 0.0264103765727431 0.00368 0.0497 0.169 0.138 0.221 1.18 0.903 1.56 0.0285 0.144 0.843 1.03 0.775 1.37 0.0392 0.143 0.784 1.04 0.785 1.38 ukb-melanoma-latest-gwas all 323 Encephalitis Neurological Both 0.91 0.815 1.02 0.0913 353 3530 FALSE 1.0395292224657 -0.0947 0.0561 -0.191 0.153 0.212 0.826 0.61 1.12 -0.289 0.157 0.065 0.749 0.549 1.02 -0.212 0.155 0.172 0.809 0.595 1.1 ukb-melanoma-latest-gwas all 323.2 Acute (transverse) myelitis Neurological Both 0.748 0.586 0.953 0.0177 74 740 TRUE 1.75202673363819 -0.29 0.122 -0.453 0.327 0.167 0.636 0.326 1.21 -0.352 0.317 0.267 0.703 0.37 1.31 -0.731 0.356 0.0402 0.481 0.229 0.962 ukb-melanoma-latest-gwas all 324 Other CNS infection and poliomyelitis Neurological Both 1.06 0.942 1.2 0.32 295 2950 FALSE 0.494850021680094 0.0609 0.0612 0.191 0.174 0.271 1.21 0.86 1.71 0.3 0.171 0.0791 1.35 0.966 1.9 -0.089 0.184 0.629 0.915 0.635 1.32 ukb-melanoma-latest-gwas all 327 Sleep disorders Neurological Both 0.979 0.922 1.04 0.49 1170 11700 FALSE 0.309803919971486 -0.0213 0.0308 0.0678 0.0865 0.433 1.07 0.903 1.27 0.0689 0.0867 0.427 1.07 0.904 1.27 -0.0202 0.0891 0.821 0.98 0.823 1.17 ukb-melanoma-latest-gwas all 327.3 Sleep apnea Neurological Both 1.02 0.922 1.13 0.678 404 4040 FALSE 0.168770306132937 0.0218 0.0524 0.0466 0.146 0.75 1.05 0.785 1.4 0.0135 0.148 0.928 1.01 0.757 1.36 -0.0023 0.149 0.988 0.998 0.744 1.34 ukb-melanoma-latest-gwas all 327.4 Insomnia Neurological Both 0.959 0.816 1.13 0.611 165 1650 FALSE 0.213958789757446 -0.0417 0.0819 -0.0934 0.228 0.681 0.911 0.579 1.43 -0.164 0.232 0.48 0.849 0.533 1.34 0.0172 0.226 0.939 1.02 0.65 1.59 ukb-melanoma-latest-gwas all 327.41 Organic or persistent insomnia Neurological Both 0.945 0.792 1.13 0.53 138 1380 FALSE 0.275724130399211 -0.0562 0.0896 -0.107 0.246 0.663 0.898 0.551 1.46 -0.224 0.254 0.379 0.8 0.48 1.32 -0.0503 0.246 0.838 0.951 0.583 1.55 ukb-melanoma-latest-gwas all 331 Other cerebral degenerations Neurological Both 0.987 0.928 1.05 0.662 1146 11460 FALSE 0.1791420105603 -0.0136 0.0311 0.066 0.0873 0.45 1.07 0.9 1.27 0.00178 0.0887 0.984 1 0.842 1.19 0.0198 0.0888 0.823 1.02 0.857 1.21 ukb-melanoma-latest-gwas all 331.1 Hydrocephalus Neurological Both 1.01 0.917 1.1 0.899 502 5020 FALSE 0.0462403082667712 0.00597 0.0469 -0.0315 0.133 0.813 0.969 0.745 1.26 0.0295 0.132 0.822 1.03 0.795 1.33 -0.0138 0.133 0.918 0.986 0.759 1.28 ukb-melanoma-latest-gwas all 331.9 Cerebral degeneration, unspecified Neurological Both 0.978 0.885 1.08 0.661 429 4290 FALSE 0.17979854051436 -0.0222 0.0507 0.206 0.142 0.146 1.23 0.93 1.63 0.0252 0.147 0.864 1.03 0.767 1.37 0.106 0.146 0.468 1.11 0.834 1.48 ukb-melanoma-latest-gwas all 332 Parkinson's disease Neurological Both 1.01 0.954 1.08 0.654 1128 11280 FALSE 0.184422251675733 0.014 0.0313 0.181 0.0879 0.0394 1.2 1.01 1.42 0.0544 0.0905 0.548 1.06 0.884 1.26 0.0716 0.0904 0.428 1.07 0.9 1.28 ukb-melanoma-latest-gwas all 333 Extrapyramidal disease and abnormal movement disorders Neurological Both 1.02 0.953 1.09 0.555 901 9010 FALSE 0.255707016877324 0.0207 0.035 -0.0927 0.1 0.354 0.911 0.748 1.11 -0.00267 0.098 0.978 0.997 0.823 1.21 0.0288 0.0978 0.769 1.03 0.849 1.25 ukb-melanoma-latest-gwas all 333.1 Essential tremor Neurological Both 1.04 0.906 1.2 0.559 216 2160 FALSE 0.252588192113577 0.0416 0.0712 -0.229 0.209 0.272 0.795 0.524 1.2 0.0855 0.194 0.66 1.09 0.743 1.6 0.0156 0.198 0.937 1.02 0.687 1.5 ukb-melanoma-latest-gwas all 333.2 Myoclonus Neurological Both 0.944 0.763 1.17 0.592 96 960 FALSE 0.22767829327708 -0.0574 0.107 -0.0915 0.304 0.764 0.913 0.495 1.67 0.106 0.291 0.716 1.11 0.622 1.99 0.0737 0.305 0.809 1.08 0.585 1.98 ukb-melanoma-latest-gwas all 333.4 Torsion dystonia Neurological Both 0.981 0.862 1.12 0.766 253 2530 FALSE 0.115771230367396 -0.0196 0.0658 -0.128 0.185 0.489 0.88 0.609 1.27 -0.0821 0.184 0.656 0.921 0.64 1.32 -0.0049 0.181 0.978 0.995 0.696 1.42 ukb-melanoma-latest-gwas all 334 Degenerative disease of the spinal cord Neurological Both 1.02 0.968 1.07 0.524 1818 18180 FALSE 0.280668713016273 0.0158 0.0247 0.0244 0.0701 0.728 1.02 0.893 1.18 0.0536 0.0699 0.443 1.06 0.92 1.21 0.05 0.0702 0.476 1.05 0.916 1.21 ukb-melanoma-latest-gwas all 334.1 Spinocerebellar disease Neurological Both 1 0.831 1.22 0.963 117 1170 FALSE 0.0163737128754655 0.00445 0.0963 0.127 0.262 0.629 1.13 0.675 1.92 -0.375 0.298 0.208 0.687 0.375 1.24 0.131 0.264 0.619 1.14 0.677 1.93 ukb-melanoma-latest-gwas all 334.2 Anterior horn cell disease Neurological Both 0.956 0.839 1.09 0.496 245 2450 FALSE 0.304518323509803 -0.0452 0.0665 -0.0807 0.19 0.671 0.923 0.633 1.34 0.154 0.181 0.396 1.17 0.817 1.67 -0.149 0.194 0.441 0.861 0.586 1.26 ukb-melanoma-latest-gwas all 335 Multiple sclerosis Neurological Both 0.977 0.923 1.03 0.41 1354 13540 FALSE 0.387216143280265 -0.0236 0.0286 -0.188 0.0804 0.0192 0.828 0.707 0.97 -0.0565 0.0781 0.469 0.945 0.811 1.1 -0.181 0.0808 0.0248 0.834 0.712 0.977 ukb-melanoma-latest-gwas all 337 Disorders of the autonomic nervous system Neurological Both 1.04 0.913 1.17 0.584 269 2690 FALSE 0.233587152887601 0.035 0.0639 -0.0472 0.185 0.798 0.954 0.662 1.37 0.137 0.178 0.441 1.15 0.808 1.63 0.0865 0.182 0.634 1.09 0.762 1.56 ukb-melanoma-latest-gwas all 337.1 Peripheral autonomic neuropathy Neurological Both 1.02 0.804 1.31 0.849 72 720 FALSE 0.0710923097560473 0.0232 0.122 0.0413 0.343 0.904 1.04 0.523 2.08 -0.0196 0.344 0.955 0.981 0.489 1.97 0.18 0.34 0.597 1.2 0.609 2.38 ukb-melanoma-latest-gwas all 338 Pain Neurological Both 0.979 0.909 1.05 0.58 772 7720 FALSE 0.236572006437063 -0.0209 0.0378 -0.16 0.108 0.137 0.852 0.689 1.05 -0.0414 0.105 0.693 0.959 0.781 1.18 -0.0492 0.105 0.64 0.952 0.774 1.17 ukb-melanoma-latest-gwas all 338.1 Acute pain Neurological Both 0.938 0.846 1.04 0.227 395 3950 FALSE 0.643974142806877 -0.0636 0.0526 -0.0767 0.149 0.605 0.926 0.691 1.24 0.052 0.144 0.718 1.05 0.793 1.4 -0.169 0.152 0.266 0.845 0.626 1.14 ukb-melanoma-latest-gwas all 338.2 Chronic pain Neurological Both 1.02 0.914 1.13 0.769 383 3830 FALSE 0.114073660198569 0.0158 0.0537 -0.197 0.152 0.197 0.822 0.608 1.11 -0.203 0.152 0.183 0.816 0.604 1.1 0.0505 0.145 0.727 1.05 0.791 1.4 ukb-melanoma-latest-gwas all 339 Other headache syndromes Neurological Both 1.02 0.997 1.04 0.0911 7843 78413 FALSE 1.040481623027 0.0201 0.0119 0.0263 0.034 0.439 1.03 0.961 1.1 0.0684 0.0337 0.0423 1.07 1 1.14 0.068 0.0339 0.0446 1.07 1 1.14 ukb-melanoma-latest-gwas all 340 Migraine Neurological Both 1.03 0.988 1.07 0.177 2867 28670 FALSE 0.752026733638193 0.0265 0.0197 -0.026 0.056 0.642 0.974 0.873 1.09 -0.0283 0.0561 0.614 0.972 0.871 1.09 0.0872 0.0548 0.112 1.09 0.98 1.22 ukb-melanoma-latest-gwas all 340.1 Migrain with aura Neurological Both 0.963 0.836 1.11 0.602 212 2120 FALSE 0.220403508742175 -0.0376 0.072 0.118 0.2 0.553 1.13 0.759 1.67 0.0376 0.204 0.854 1.04 0.694 1.56 -0.061 0.21 0.771 0.941 0.621 1.42 ukb-melanoma-latest-gwas all 341 Other demyelinating diseases of central nervous system Neurological Both 0.976 0.858 1.11 0.711 254 2540 FALSE 0.148130399270234 -0.0243 0.0655 -0.337 0.185 0.0683 0.714 0.494 1.03 -0.0971 0.174 0.576 0.907 0.643 1.28 -0.327 0.184 0.0761 0.721 0.5 1.04 ukb-melanoma-latest-gwas all 342 Hemiplegia Neurological Both 0.977 0.927 1.03 0.399 1498 14980 FALSE 0.399027104313252 -0.0229 0.0272 0.0793 0.0764 0.3 1.08 0.932 1.26 0.0215 0.0775 0.781 1.02 0.878 1.19 0.025 0.0778 0.748 1.03 0.88 1.19 ukb-melanoma-latest-gwas all 343 Infantile cerebral palsy Neurological Both 1.01 0.853 1.2 0.883 145 1450 FALSE 0.0540392964224314 0.0128 0.0871 0.123 0.255 0.628 1.13 0.682 1.88 0.321 0.243 0.188 1.38 0.854 2.25 0.126 0.257 0.625 1.13 0.681 1.9 ukb-melanoma-latest-gwas all 344 Other paralytic syndromes Neurological Both 1.05 0.968 1.14 0.245 661 6610 FALSE 0.610833915635468 0.0475 0.0409 0.137 0.116 0.24 1.15 0.912 1.44 0.132 0.117 0.255 1.14 0.908 1.44 0.0796 0.118 0.5 1.08 0.859 1.37 ukb-melanoma-latest-gwas all 345 Epilepsy, recurrent seizures, convulsions Neurological Both 0.995 0.967 1.02 0.745 5083 50830 FALSE 0.127843727251707 -0.00482 0.0148 0.0559 0.0417 0.18 1.06 0.975 1.15 0.0233 0.042 0.579 1.02 0.943 1.11 0.0435 0.0421 0.301 1.04 0.962 1.13 ukb-melanoma-latest-gwas all 345.1 Epilepsy Neurological Both 1 0.937 1.08 0.922 898 8980 FALSE 0.0352690789463706 0.00346 0.0351 0.152 0.0999 0.128 1.16 0.957 1.42 0.192 0.0992 0.0531 1.21 0.997 1.47 0.0141 0.104 0.891 1.01 0.828 1.24 ukb-melanoma-latest-gwas all 345.3 Convulsions Neurological Both 0.996 0.953 1.04 0.849 2235 22350 FALSE 0.0710923097560473 -0.00424 0.0223 0.0181 0.063 0.774 1.02 0.9 1.15 0.0106 0.0632 0.867 1.01 0.893 1.14 0.0501 0.0632 0.428 1.05 0.929 1.19 ukb-melanoma-latest-gwas all 345.11 Generalized convulsive epilepsy Neurological Both 1.01 0.92 1.12 0.767 445 4450 FALSE 0.115204636051019 0.0148 0.0499 0.166 0.142 0.243 1.18 0.893 1.56 0.175 0.141 0.216 1.19 0.903 1.58 0.0579 0.146 0.692 1.06 0.795 1.41 ukb-melanoma-latest-gwas all 345.12 Partial epilepsy Neurological Both 1.03 0.911 1.17 0.627 279 2790 FALSE 0.202732459169284 0.0306 0.0629 0.262 0.18 0.145 1.3 0.913 1.86 0.234 0.181 0.197 1.26 0.885 1.81 0.123 0.186 0.507 1.13 0.785 1.63 ukb-melanoma-latest-gwas all 348 Other conditions of brain Neurological Both 1.05 0.978 1.13 0.168 791 7910 FALSE 0.774690718274137 0.0515 0.0374 0.0657 0.109 0.547 1.07 0.862 1.32 0.197 0.106 0.0637 1.22 0.989 1.5 0.171 0.107 0.111 1.19 0.961 1.46 ukb-melanoma-latest-gwas all 348.2 Cerebral edema and compression of brain Neurological Both 1.08 0.954 1.23 0.215 268 2680 FALSE 0.667561540084395 0.0797 0.0643 -0.0477 0.192 0.804 0.953 0.652 1.39 0.252 0.181 0.164 1.29 0.902 1.84 0.292 0.182 0.108 1.34 0.937 1.92 ukb-melanoma-latest-gwas all 348.4 Cerebral cysts Neurological Both 1.05 0.881 1.25 0.571 136 1360 FALSE 0.243363891754152 0.0506 0.0893 -0.00679 0.247 0.978 0.993 0.608 1.62 -0.32 0.267 0.231 0.726 0.423 1.23 0.127 0.24 0.597 1.14 0.707 1.83 ukb-melanoma-latest-gwas all 348.8 Encephalopathy, not elsewhere classified Neurological Both 1 0.88 1.14 0.971 252 2520 FALSE 0.0127807700919951 0.00241 0.066 0.229 0.185 0.217 1.26 0.873 1.82 0.144 0.189 0.444 1.16 0.797 1.68 0.0105 0.195 0.957 1.01 0.688 1.49 ukb-melanoma-latest-gwas all 349 Other and unspecified disorders of the nervous system Neurological Both 0.983 0.879 1.1 0.756 342 3420 FALSE 0.121478204498793 -0.0176 0.0567 -0.0775 0.156 0.619 0.925 0.68 1.26 -0.119 0.158 0.45 0.888 0.65 1.21 -0.181 0.16 0.261 0.835 0.608 1.14 ukb-melanoma-latest-gwas all 350 Abnormal movement Neurological Both 1.03 0.994 1.08 0.0962 2691 26910 FALSE 1.01682492796219 0.0338 0.0203 0.00813 0.0581 0.889 1.01 0.9 1.13 0.0736 0.0574 0.199 1.08 0.962 1.2 0.0603 0.0577 0.296 1.06 0.949 1.19 ukb-melanoma-latest-gwas all 350.1 Abnormal involuntary movements Neurological Both 1.04 0.967 1.11 0.313 888 8880 FALSE 0.504455662453552 0.0356 0.0353 0.0655 0.102 0.521 1.07 0.874 1.31 0.158 0.1 0.114 1.17 0.963 1.43 0.132 0.101 0.193 1.14 0.936 1.39 ukb-melanoma-latest-gwas all 350.2 Abnormality of gait Neurological Both 1.05 0.997 1.11 0.0635 1599 15990 FALSE 1.19722627470802 0.049 0.0264 0.00586 0.0757 0.938 1.01 0.867 1.17 0.0981 0.0743 0.187 1.1 0.953 1.28 0.0629 0.0751 0.402 1.06 0.919 1.23 ukb-melanoma-latest-gwas all 350.3 Lack of coordination Neurological Both 0.974 0.874 1.09 0.631 364 3640 FALSE 0.199970640755866 -0.0264 0.0549 -0.487 0.157 0.00187 0.614 0.45 0.834 -0.198 0.146 0.176 0.821 0.614 1.09 -0.335 0.151 0.0265 0.715 0.53 0.961 ukb-melanoma-latest-gwas all 351 Other peripheral nerve disorders Neurological Both 1.01 0.996 1.03 0.127 12454 124540 FALSE 0.896196279044043 0.0144 0.00944 0.00758 0.0267 0.776 1.01 0.956 1.06 -0.017 0.0268 0.526 0.983 0.933 1.04 0.034 0.0266 0.201 1.03 0.982 1.09 ukb-melanoma-latest-gwas all 352 Disorders of other cranial nerves Neurological Both 1.07 1.01 1.13 0.023 1391 13910 TRUE 1.63827216398241 0.0643 0.0283 0.0156 0.0812 0.847 1.02 0.866 1.19 0.0438 0.0808 0.587 1.04 0.892 1.22 0.137 0.0796 0.0856 1.15 0.981 1.34 ukb-melanoma-latest-gwas all 352.1 Trigeminal nerve disorders [CN5] Neurological Both 1.05 0.951 1.15 0.354 463 4630 FALSE 0.450996737974212 0.0453 0.0489 0.127 0.141 0.366 1.14 0.861 1.5 0.105 0.141 0.459 1.11 0.841 1.47 0.196 0.139 0.159 1.22 0.926 1.6 ukb-melanoma-latest-gwas all 352.2 Facial nerve disorders [CN7] Neurological Both 1.08 1.01 1.16 0.029 880 8800 TRUE 1.53760200210104 0.0776 0.0355 -0.0326 0.102 0.749 0.968 0.792 1.18 0.0167 0.101 0.869 1.02 0.833 1.24 0.134 0.0993 0.177 1.14 0.941 1.39 ukb-melanoma-latest-gwas all 353 Nerve root and plexus disorders Neurological Both 0.981 0.922 1.04 0.532 1137 11370 FALSE 0.274088367704952 -0.0195 0.0312 0.0359 0.0873 0.681 1.04 0.873 1.23 0.00835 0.0882 0.925 1.01 0.848 1.2 -0.0271 0.089 0.76 0.973 0.817 1.16 ukb-melanoma-latest-gwas all 353.1 Nerve plexus lesions Neurological Both 0.977 0.805 1.19 0.815 114 1140 FALSE 0.0888423912600234 -0.0229 0.0977 0.0536 0.268 0.842 1.06 0.619 1.8 0.0555 0.269 0.836 1.06 0.619 1.81 -0.192 0.283 0.497 0.825 0.466 1.45 ukb-melanoma-latest-gwas all 353.2 Nerve root lesions Neurological Both 0.846 0.648 1.11 0.211 57 570 FALSE 0.675717544702307 -0.168 0.134 -0.106 0.377 0.778 0.899 0.419 1.92 0.0494 0.366 0.893 1.05 0.503 2.2 -0.18 0.393 0.647 0.835 0.373 1.84 ukb-melanoma-latest-gwas all 356 Hereditary and idiopathic peripheral neuropathy Neurological Both 0.945 0.799 1.12 0.507 152 1520 FALSE 0.294992040666664 -0.0563 0.0848 -0.168 0.231 0.466 0.845 0.533 1.33 -0.24 0.233 0.304 0.787 0.494 1.25 -0.253 0.234 0.28 0.777 0.486 1.23 ukb-melanoma-latest-gwas all 357 Inflammatory and toxic neuropathy Neurological Both 0.956 0.904 1.01 0.11 1367 13670 FALSE 0.958607314841775 -0.0455 0.0285 -0.139 0.0787 0.0774 0.87 0.745 1.02 -0.155 0.0792 0.0507 0.857 0.733 1 -0.155 0.0795 0.0507 0.856 0.732 1 ukb-melanoma-latest-gwas all 358 Myoneural disorders Neurological Both 1.07 0.932 1.24 0.319 213 2130 FALSE 0.496209316942819 0.0715 0.0718 0.18 0.211 0.394 1.2 0.789 1.82 0.27 0.207 0.191 1.31 0.873 1.98 0.297 0.207 0.152 1.35 0.895 2.03 ukb-melanoma-latest-gwas all 358.1 Myasthenia gravis Neurological Both 1.1 0.951 1.28 0.192 192 1920 FALSE 0.71669877129645 0.0988 0.0758 0.176 0.224 0.432 1.19 0.766 1.86 0.309 0.219 0.158 1.36 0.886 2.11 0.348 0.219 0.111 1.42 0.922 2.19 ukb-melanoma-latest-gwas all 359 Muscular dystrophies and other myopathies Neurological Both 0.943 0.858 1.04 0.23 469 4690 FALSE 0.638272163982407 -0.0583 0.0486 -0.0572 0.135 0.672 0.944 0.724 1.23 -0.0545 0.136 0.688 0.947 0.725 1.24 -0.0954 0.138 0.49 0.909 0.692 1.19 ukb-melanoma-latest-gwas all 359.1 Muscular dystrophies Neurological Both 0.879 0.728 1.06 0.171 122 1220 FALSE 0.767003889607846 -0.129 0.0945 -0.205 0.267 0.444 0.815 0.476 1.38 -0.0523 0.258 0.84 0.949 0.567 1.59 -0.0753 0.26 0.772 0.927 0.552 1.55 ukb-melanoma-latest-gwas all 359.2 Myopathy Neurological Both 0.956 0.858 1.07 0.421 361 3610 FALSE 0.375717904164332 -0.0445 0.0554 -0.025 0.154 0.871 0.975 0.72 1.32 0.00688 0.154 0.964 1.01 0.743 1.36 -0.141 0.16 0.379 0.869 0.633 1.19 ukb-melanoma-latest-gwas all 360 Disorders of the globe Sense Organs Both 1.05 0.936 1.17 0.416 337 3370 FALSE 0.380906669373257 0.0464 0.0571 -0.125 0.165 0.448 0.882 0.636 1.22 -0.13 0.165 0.432 0.878 0.634 1.22 0.199 0.154 0.197 1.22 0.901 1.66 ukb-melanoma-latest-gwas all 360.2 Progressive myopia Sense Organs Both 1.06 0.933 1.21 0.359 251 2510 FALSE 0.444905551421681 0.0608 0.0663 -0.0339 0.189 0.857 0.967 0.665 1.4 -0.0569 0.189 0.764 0.945 0.649 1.37 0.149 0.182 0.414 1.16 0.811 1.67 ukb-melanoma-latest-gwas all 361 Retinal detachments and defects Sense Organs Both 0.961 0.927 0.996 0.0308 3256 32560 TRUE 1.51144928349956 -0.0398 0.0184 -0.0342 0.051 0.503 0.966 0.874 1.07 -0.105 0.0519 0.0428 0.9 0.813 0.997 -0.117 0.0522 0.0254 0.89 0.803 0.986 ukb-melanoma-latest-gwas all 361.1 Retinal detachment with retinal defect Sense Organs Both 1 0.951 1.06 0.865 1389 13890 FALSE 0.0629838925351858 0.0048 0.0283 0.0462 0.079 0.558 1.05 0.897 1.22 0.0059 0.0799 0.941 1.01 0.86 1.18 -0.0326 0.0808 0.686 0.968 0.826 1.13 ukb-melanoma-latest-gwas all 361.2 Retinoschisis and retinal cysts Sense Organs Both 1.02 0.796 1.31 0.867 68 680 FALSE 0.0619809025237897 0.0211 0.125 0.217 0.343 0.527 1.24 0.628 2.49 -0.18 0.372 0.628 0.835 0.389 1.76 0.112 0.347 0.747 1.12 0.559 2.26 ukb-melanoma-latest-gwas all 362 Other retinal disorders Sense Organs Both 1.01 0.977 1.04 0.537 3858 38580 FALSE 0.270025714300444 0.0105 0.017 0.0553 0.0483 0.252 1.06 0.961 1.16 0.0687 0.0482 0.154 1.07 0.975 1.18 0.0718 0.0483 0.137 1.07 0.977 1.18 ukb-melanoma-latest-gwas all 362.2 Degeneration of macula and posterior pole of retina Sense Organs Both 1.01 0.969 1.06 0.568 2184 21840 FALSE 0.245651664288981 0.0129 0.0225 0.0485 0.0641 0.449 1.05 0.926 1.19 0.0574 0.0639 0.369 1.06 0.934 1.2 0.0625 0.0643 0.331 1.06 0.938 1.21 ukb-melanoma-latest-gwas all 362.3 Other nondiabetic retinopathy Sense Organs Both 0.945 0.803 1.11 0.489 160 1600 FALSE 0.31069114087638 -0.057 0.0825 -0.00284 0.224 0.99 0.997 0.64 1.55 -0.177 0.234 0.45 0.838 0.525 1.33 -0.108 0.232 0.642 0.898 0.565 1.42 ukb-melanoma-latest-gwas all 362.4 Retinal vascular changes and abnomalities Sense Organs Both 1.05 0.975 1.12 0.208 847 8470 FALSE 0.681936665037238 0.0455 0.0361 0.000939 0.105 0.993 1 0.814 1.23 0.161 0.102 0.115 1.17 0.961 1.44 0.152 0.102 0.138 1.16 0.953 1.42 ukb-melanoma-latest-gwas all 362.6 Peripheral retinal degenerations Sense Organs Both 1 0.861 1.17 0.973 183 1830 FALSE 0.0118871597316481 0.00267 0.0774 0.0698 0.219 0.75 1.07 0.695 1.66 0.0068 0.223 0.976 1.01 0.647 1.57 0.189 0.217 0.383 1.21 0.788 1.86 ukb-melanoma-latest-gwas all 362.7 Hereditary retinal dystrophies Sense Organs Both 0.993 0.791 1.25 0.952 82 820 FALSE 0.0213630516155257 -0.00693 0.115 0.147 0.314 0.639 1.16 0.621 2.18 -0.157 0.335 0.639 0.855 0.433 1.67 -0.0583 0.325 0.858 0.943 0.491 1.81 ukb-melanoma-latest-gwas all 362.8 Retinal hemorrhage/ischemia Sense Organs Both 1.09 0.9 1.32 0.374 116 1160 FALSE 0.42712839779952 0.086 0.0968 0.6 0.29 0.0387 1.82 1.03 3.3 0.577 0.294 0.0498 1.78 1 3.25 0.344 0.302 0.254 1.41 0.775 2.62 ukb-melanoma-latest-gwas all 362.29 Macular degeneration (senile) of retina NOS Sense Organs Both 1.01 0.97 1.06 0.542 2181 21810 FALSE 0.266000713461613 0.0138 0.0226 0.0487 0.0641 0.447 1.05 0.926 1.19 0.0579 0.064 0.365 1.06 0.935 1.2 0.0646 0.0643 0.315 1.07 0.94 1.21 ukb-melanoma-latest-gwas all 362.31 Separation of retinal layers Sense Organs Both 0.929 0.757 1.14 0.477 99 990 FALSE 0.321481620959886 -0.0738 0.104 0.186 0.273 0.494 1.2 0.703 2.08 -0.397 0.31 0.2 0.673 0.358 1.24 -0.175 0.295 0.553 0.839 0.463 1.51 ukb-melanoma-latest-gwas all 363 Chorioretinal inflammations, scars, and other disorders of choroid Sense Organs Both 0.932 0.797 1.09 0.375 171 1710 FALSE 0.425968732272281 -0.0705 0.0794 0.245 0.223 0.272 1.28 0.823 2 0.333 0.222 0.133 1.39 0.903 2.17 -0.149 0.245 0.544 0.862 0.527 1.4 ukb-melanoma-latest-gwas all 363.3 Chorioretinal scars Sense Organs Both 0.854 0.67 1.09 0.2 69 690 FALSE 0.698970004336019 -0.157 0.123 0.339 0.344 0.324 1.4 0.711 2.84 0.356 0.354 0.315 1.43 0.706 2.94 -0.0933 0.374 0.803 0.911 0.425 1.94 ukb-melanoma-latest-gwas all 364 Corneal opacity and other disorders of cornea Sense Organs Both 0.938 0.866 1.02 0.12 658 6580 FALSE 0.920818753952375 -0.0636 0.0409 -0.117 0.114 0.305 0.889 0.71 1.11 -0.0556 0.113 0.622 0.946 0.758 1.18 -0.15 0.116 0.195 0.861 0.685 1.08 ukb-melanoma-latest-gwas all 364.2 Corneal edema Sense Organs Both 0.881 0.7 1.11 0.273 80 800 FALSE 0.563837352959244 -0.127 0.116 0.015 0.323 0.963 1.02 0.53 1.94 -0.0112 0.321 0.972 0.989 0.52 1.88 -0.0482 0.325 0.882 0.953 0.495 1.83 ukb-melanoma-latest-gwas all 364.4 Corneal degenerations Sense Organs Both 0.984 0.853 1.14 0.824 208 2080 FALSE 0.0840727883028842 -0.0161 0.0726 -0.056 0.204 0.784 0.946 0.631 1.41 -0.0045 0.201 0.982 0.996 0.669 1.48 -0.0995 0.205 0.627 0.905 0.603 1.36 ukb-melanoma-latest-gwas all 364.5 Corneal dystrophy Sense Organs Both 1.05 0.915 1.22 0.457 211 2110 FALSE 0.34008379993015 0.0535 0.072 -0.116 0.209 0.58 0.891 0.587 1.35 0.124 0.199 0.532 1.13 0.765 1.68 0.0495 0.203 0.807 1.05 0.704 1.57 ukb-melanoma-latest-gwas all 364.9 Cornea replaced by transplant Sense Organs Both 1.14 0.924 1.4 0.221 100 1000 FALSE 0.655607726314889 0.127 0.104 0.307 0.315 0.329 1.36 0.729 2.58 0.389 0.308 0.205 1.48 0.804 2.77 0.428 0.306 0.162 1.53 0.84 2.87 ukb-melanoma-latest-gwas all 364.41 Keratoconus Sense Organs Both 0.976 0.783 1.22 0.83 87 870 FALSE 0.0809219076239261 -0.024 0.111 -0.0971 0.311 0.755 0.907 0.485 1.69 -0.022 0.302 0.942 0.978 0.535 1.79 -0.202 0.317 0.524 0.817 0.431 1.54 ukb-melanoma-latest-gwas all 365 Glaucoma Sense Organs Both 0.995 0.965 1.03 0.756 4430 44300 FALSE 0.121478204498793 -0.00492 0.0158 -0.00355 0.0442 0.936 0.996 0.914 1.09 -0.0667 0.0448 0.137 0.935 0.857 1.02 -0.0256 0.0446 0.566 0.975 0.893 1.06 ukb-melanoma-latest-gwas all 365.1 Open-angle glaucoma Sense Organs Both 1.02 0.955 1.09 0.567 1029 10290 FALSE 0.246416941107093 0.0188 0.0328 0.19 0.0916 0.038 1.21 1.01 1.45 -0.0144 0.0956 0.88 0.986 0.817 1.19 0.0723 0.094 0.442 1.07 0.894 1.29 ukb-melanoma-latest-gwas all 365.2 Primary angle-closure glaucoma Sense Organs Both 1.01 0.938 1.1 0.727 700 7000 FALSE 0.138465589140962 0.0139 0.0397 0.1 0.114 0.378 1.11 0.884 1.38 0.126 0.113 0.263 1.13 0.909 1.42 0.111 0.114 0.331 1.12 0.893 1.4 ukb-melanoma-latest-gwas all 365.11 Primary open angle glaucoma Sense Organs Both 1.02 0.96 1.09 0.478 1023 10230 FALSE 0.320572103387881 0.0234 0.0329 0.203 0.0919 0.0273 1.22 1.02 1.47 -0.014 0.0962 0.884 0.986 0.816 1.19 0.0851 0.0943 0.367 1.09 0.905 1.31 ukb-melanoma-latest-gwas all 366 Cataract Sense Organs Both 1 0.989 1.02 0.627 19997 169205 FALSE 0.202732459169284 0.00365 0.00753 -0.0058 0.0213 0.785 0.994 0.954 1.04 0.0194 0.0212 0.361 1.02 0.978 1.06 -0.00572 0.0214 0.789 0.994 0.954 1.04 ukb-melanoma-latest-gwas all 366.1 Nonsenile Cataract Sense Organs Both 1.15 0.898 1.48 0.263 70 700 FALSE 0.580044251510242 0.14 0.125 -0.0862 0.408 0.833 0.917 0.394 2.11 0.651 0.358 0.0691 1.92 0.951 4.04 0.585 0.359 0.103 1.8 0.888 3.79 ukb-melanoma-latest-gwas all 366.2 Senile cataract Sense Organs Both 1.01 0.991 1.04 0.235 8261 82116 FALSE 0.628932137728264 0.0138 0.0116 0.0164 0.0329 0.618 1.02 0.953 1.08 0.05 0.0327 0.126 1.05 0.986 1.12 0.0177 0.033 0.591 1.02 0.954 1.09 ukb-melanoma-latest-gwas all 366.3 Traumatic cataract Sense Organs Both 0.974 0.794 1.19 0.795 102 1020 FALSE 0.0996328713435297 -0.0268 0.103 0.178 0.275 0.517 1.2 0.693 2.08 -0.225 0.306 0.461 0.798 0.429 1.47 -0.0572 0.29 0.843 0.944 0.529 1.68 ukb-melanoma-latest-gwas all 367 Disorders of refraction and accommodation; blindness and low vision Sense Organs Both 1 0.96 1.04 0.94 2428 24280 FALSE 0.0268721464003014 0.0016 0.0214 0.00402 0.0604 0.947 1 0.892 1.13 0.0129 0.0603 0.831 1.01 0.9 1.14 0.0149 0.0606 0.805 1.02 0.901 1.14 ukb-melanoma-latest-gwas all 367.1 Myopia Sense Organs Both 1.01 0.957 1.08 0.63 1255 12550 FALSE 0.200659450546418 0.0143 0.0297 0.0174 0.0842 0.836 1.02 0.863 1.2 -0.00467 0.0847 0.956 0.995 0.843 1.18 0.0719 0.0837 0.39 1.07 0.912 1.27 ukb-melanoma-latest-gwas all 367.2 Astigmatism Sense Organs Both 0.887 0.764 1.03 0.116 190 1900 FALSE 0.935542010773082 -0.119 0.076 -0.133 0.209 0.527 0.876 0.578 1.32 -0.0534 0.205 0.794 0.948 0.631 1.42 -0.303 0.22 0.169 0.738 0.475 1.14 ukb-melanoma-latest-gwas all 367.8 Hypermetropia Sense Organs Both 1.02 0.894 1.16 0.786 252 2520 FALSE 0.104577453960592 0.0179 0.066 -0.255 0.188 0.175 0.775 0.533 1.12 -0.0469 0.18 0.795 0.954 0.668 1.36 -0.127 0.183 0.489 0.881 0.612 1.26 ukb-melanoma-latest-gwas all 367.9 Blindness and low vision Sense Organs Both 1.01 0.939 1.09 0.729 723 7230 FALSE 0.137272471682025 0.0135 0.0391 0.115 0.11 0.296 1.12 0.904 1.39 -0.00574 0.113 0.959 0.994 0.796 1.24 0.104 0.111 0.347 1.11 0.893 1.38 ukb-melanoma-latest-gwas all 368 Visual disturbances Sense Organs Both 1.02 0.984 1.06 0.263 2990 29900 FALSE 0.580044251510242 0.0216 0.0193 0.0217 0.0547 0.692 1.02 0.918 1.14 0.0137 0.0549 0.802 1.01 0.91 1.13 0.0829 0.0542 0.126 1.09 0.977 1.21 ukb-melanoma-latest-gwas all 368.1 Amblyopia Sense Organs Both 1.07 0.977 1.17 0.149 535 5350 FALSE 0.826813731587726 0.0656 0.0454 0.133 0.131 0.311 1.14 0.883 1.48 0.149 0.13 0.255 1.16 0.898 1.5 0.167 0.13 0.198 1.18 0.916 1.53 ukb-melanoma-latest-gwas all 368.2 Diplopia and disorders of binocular vision Sense Organs Both 0.996 0.923 1.08 0.917 730 7300 FALSE 0.0376306643299789 -0.00407 0.0389 -0.166 0.112 0.138 0.847 0.68 1.06 0.00559 0.108 0.959 1.01 0.814 1.24 -0.00785 0.108 0.942 0.992 0.802 1.23 ukb-melanoma-latest-gwas all 368.3 Anisometropia Sense Organs Both 1.06 0.9 1.26 0.466 155 1550 FALSE 0.33161408331 0.0616 0.0845 -0.109 0.248 0.66 0.897 0.546 1.47 0.0535 0.239 0.823 1.05 0.656 1.7 0.203 0.231 0.379 1.23 0.778 1.94 ukb-melanoma-latest-gwas all 368.9 Subjective visual disturbances Sense Organs Both 1.02 0.941 1.11 0.593 614 6140 FALSE 0.226945306635737 0.0226 0.0424 -0.0792 0.12 0.507 0.924 0.73 1.17 -0.109 0.121 0.365 0.896 0.707 1.14 0.0515 0.117 0.658 1.05 0.837 1.32 ukb-melanoma-latest-gwas all 369 Infection of the eye Sense Organs Both 0.982 0.9 1.07 0.688 560 5600 FALSE 0.162411561764489 -0.0178 0.0444 -0.0548 0.125 0.662 0.947 0.74 1.21 0.00882 0.123 0.943 1.01 0.791 1.29 -0.0445 0.126 0.723 0.956 0.747 1.22 ukb-melanoma-latest-gwas all 369.2 Eye infection, viral Sense Organs Both 1.06 0.882 1.27 0.532 126 1260 FALSE 0.274088367704952 0.0582 0.0931 0.119 0.268 0.656 1.13 0.661 1.93 0.166 0.264 0.53 1.18 0.7 2.01 0.0899 0.268 0.737 1.09 0.643 1.87 ukb-melanoma-latest-gwas all 369.5 Conjunctivitis, infectious Sense Organs Both 0.956 0.831 1.1 0.529 213 2130 FALSE 0.276544327964814 -0.045 0.0715 -0.00114 0.192 0.995 0.999 0.683 1.46 -0.293 0.206 0.155 0.746 0.495 1.12 -0.124 0.2 0.534 0.883 0.594 1.31 ukb-melanoma-latest-gwas all 370 Keratitis Sense Organs Both 0.947 0.84 1.07 0.371 297 2970 FALSE 0.430626090384954 -0.0546 0.061 -0.139 0.174 0.422 0.87 0.616 1.22 -0.0232 0.17 0.891 0.977 0.699 1.37 -0.0451 0.17 0.791 0.956 0.683 1.34 ukb-melanoma-latest-gwas all 370.1 Corneal ulcer Sense Organs Both 0.934 0.785 1.11 0.432 141 1410 FALSE 0.364516253185088 -0.0688 0.0876 -0.172 0.25 0.492 0.842 0.511 1.38 0.0931 0.236 0.694 1.1 0.688 1.76 -0.192 0.251 0.446 0.826 0.499 1.36 ukb-melanoma-latest-gwas all 371 Inflammation of the eye Sense Organs Both 1.01 0.977 1.05 0.49 3168 31680 FALSE 0.309803919971486 0.0129 0.0187 0.0145 0.0534 0.785 1.01 0.914 1.13 0.0652 0.0528 0.217 1.07 0.962 1.18 0.0527 0.0531 0.321 1.05 0.95 1.17 ukb-melanoma-latest-gwas all 371.1 Uveitis, noninfectious or NOS Sense Organs Both 0.993 0.904 1.09 0.886 486 4860 FALSE 0.0525662781129492 -0.00686 0.0476 -0.0502 0.136 0.711 0.951 0.728 1.24 0.0358 0.132 0.787 1.04 0.799 1.35 -0.0356 0.135 0.792 0.965 0.74 1.26 ukb-melanoma-latest-gwas all 371.3 Inflammation of eyelids Sense Organs Both 1.02 0.981 1.07 0.286 2391 23910 FALSE 0.543633966870957 0.023 0.0215 0.0743 0.0617 0.229 1.08 0.954 1.22 0.119 0.0612 0.051 1.13 0.999 1.27 0.101 0.0616 0.0999 1.11 0.981 1.25 ukb-melanoma-latest-gwas all 372 Disorders of conjunctiva Sense Organs Both 0.988 0.917 1.06 0.749 764 7640 FALSE 0.125518182300534 -0.0122 0.038 -0.13 0.107 0.224 0.878 0.711 1.08 -0.0591 0.105 0.575 0.943 0.766 1.16 -0.105 0.107 0.326 0.9 0.73 1.11 ukb-melanoma-latest-gwas all 374 Other disorders of eyelids Sense Organs Both 1.02 0.99 1.05 0.213 5700 57000 FALSE 0.671620396561262 0.0174 0.014 -0.00211 0.0393 0.957 0.998 0.924 1.08 -0.0417 0.0397 0.294 0.959 0.887 1.04 0.0418 0.0391 0.286 1.04 0.966 1.13 ukb-melanoma-latest-gwas all 374.1 Ectropion or entropion Sense Organs Both 1.06 0.99 1.12 0.0959 1066 10660 FALSE 1.01818139282934 0.0538 0.0323 -0.0187 0.0914 0.838 0.981 0.82 1.17 -0.121 0.0936 0.197 0.886 0.737 1.06 0.124 0.0888 0.163 1.13 0.951 1.35 ukb-melanoma-latest-gwas all 374.3 Ptosis of eyelid Sense Organs Both 0.972 0.926 1.02 0.25 1826 18260 FALSE 0.602059991327962 -0.0283 0.0246 -0.112 0.0691 0.105 0.894 0.781 1.02 -0.122 0.0692 0.0781 0.885 0.773 1.01 -0.0356 0.0683 0.602 0.965 0.844 1.1 ukb-melanoma-latest-gwas all 375 Disorders of lacrimal system Sense Organs Both 1.07 1.02 1.11 0.00393 2213 22130 TRUE 2.40560744962457 0.0647 0.0224 0.0772 0.0644 0.231 1.08 0.952 1.23 0.0269 0.0652 0.679 1.03 0.904 1.17 0.218 0.0629 0.000526 1.24 1.1 1.41 ukb-melanoma-latest-gwas all 375.2 Epiphora Sense Organs Both 1.09 1.02 1.17 0.0142 899 8990 TRUE 1.84771165561694 0.0862 0.0351 0.0375 0.101 0.711 1.04 0.851 1.27 -0.0784 0.104 0.452 0.925 0.753 1.13 0.303 0.0964 0.00167 1.35 1.12 1.64 ukb-melanoma-latest-gwas all 376 Disorders of the orbit Sense Organs Both 1.01 0.809 1.27 0.9 86 860 FALSE 0.0457574905606751 0.0143 0.114 0.289 0.312 0.355 1.34 0.719 2.52 0.182 0.321 0.571 1.2 0.633 2.29 0.0464 0.342 0.892 1.05 0.526 2.09 ukb-melanoma-latest-gwas all 377 Disorders of optic nerve and visual pathways Sense Organs Both 1.11 1 1.24 0.0489 370 3700 TRUE 1.31069114087638 0.109 0.0551 0.199 0.164 0.223 1.22 0.885 1.69 0.401 0.157 0.0107 1.49 1.1 2.04 0.249 0.162 0.123 1.28 0.934 1.77 ukb-melanoma-latest-gwas all 377.1 Optic atrophy Sense Organs Both 0.958 0.733 1.25 0.747 58 580 FALSE 0.126679398184601 -0.0434 0.135 -0.403 0.377 0.285 0.668 0.307 1.41 -0.229 0.369 0.534 0.795 0.376 1.65 -0.285 0.367 0.437 0.752 0.356 1.56 ukb-melanoma-latest-gwas all 377.3 Optic neuritis/neuropathy Sense Organs Both 1.11 0.922 1.34 0.269 125 1250 FALSE 0.570247719997592 0.104 0.0943 0.11 0.28 0.696 1.12 0.638 1.96 0.292 0.27 0.28 1.34 0.786 2.31 0.381 0.268 0.155 1.46 0.864 2.52 ukb-melanoma-latest-gwas all 378 Strabismus and other disorders of binocular eye movements Sense Organs Both 1.03 0.977 1.09 0.253 1437 14370 FALSE 0.596879478824182 0.0317 0.0278 0.0591 0.0794 0.457 1.06 0.908 1.24 0.144 0.078 0.0649 1.15 0.991 1.35 0.0476 0.0802 0.552 1.05 0.896 1.23 ukb-melanoma-latest-gwas all 378.1 Strabismus (not specified as paralytic) Sense Organs Both 1.03 0.963 1.1 0.372 915 9150 FALSE 0.429457060118102 0.0311 0.0348 0.126 0.0991 0.202 1.13 0.934 1.38 0.164 0.0985 0.0967 1.18 0.971 1.43 0.0637 0.101 0.529 1.07 0.874 1.3 ukb-melanoma-latest-gwas all 378.2 Nystagmus and other irregular eye movements Sense Organs Both 1.11 0.966 1.28 0.136 214 2140 FALSE 0.866461091629782 0.107 0.0719 0.028 0.21 0.894 1.03 0.679 1.56 0.249 0.2 0.213 1.28 0.866 1.91 0.157 0.206 0.447 1.17 0.779 1.76 ukb-melanoma-latest-gwas all 378.5 Paralytic strabismus Sense Organs Both 0.924 0.816 1.05 0.215 276 2760 FALSE 0.667561540084395 -0.0786 0.0634 -0.121 0.176 0.493 0.886 0.625 1.25 -0.0464 0.173 0.789 0.955 0.678 1.34 -0.173 0.178 0.33 0.841 0.591 1.19 ukb-melanoma-latest-gwas all 379 Other disorders of eye Sense Organs Both 0.997 0.964 1.03 0.871 3740 37400 FALSE 0.0599818449923368 -0.00279 0.0172 0.00289 0.0485 0.952 1 0.912 1.1 0.0137 0.0484 0.777 1.01 0.922 1.11 -0.016 0.0489 0.743 0.984 0.894 1.08 ukb-melanoma-latest-gwas all 379.2 Disorders of vitreous body Sense Organs Both 0.97 0.917 1.03 0.282 1368 13680 FALSE 0.549750891680639 -0.0306 0.0284 -0.0431 0.079 0.585 0.958 0.82 1.12 -0.0499 0.0792 0.529 0.951 0.814 1.11 -0.132 0.0809 0.101 0.876 0.747 1.03 ukb-melanoma-latest-gwas all 379.3 Aphakia and other disorders of lens Sense Organs Both 1.04 0.987 1.09 0.152 1810 18100 FALSE 0.818156412055227 0.0354 0.0247 0.0573 0.0706 0.416 1.06 0.922 1.22 0.0738 0.0705 0.295 1.08 0.938 1.24 0.104 0.0702 0.14 1.11 0.967 1.27 ukb-melanoma-latest-gwas all 379.4 Anomalies of pupillary function Sense Organs Both 0.85 0.662 1.09 0.192 70 700 FALSE 0.71669877129645 -0.163 0.125 0.29 0.329 0.379 1.34 0.697 2.61 -0.091 0.365 0.803 0.913 0.436 1.9 -0.0818 0.372 0.826 0.921 0.432 1.94 ukb-melanoma-latest-gwas all 379.5 Disorders of iris and ciliary body Sense Organs Both 0.993 0.896 1.1 0.889 401 4010 FALSE 0.0510982390297863 -0.00731 0.0523 -0.06 0.15 0.69 0.942 0.7 1.27 -0.0106 0.147 0.942 0.989 0.741 1.32 0.0436 0.146 0.766 1.04 0.783 1.39 ukb-melanoma-latest-gwas all 380 Disorders of external ear Sense Organs Both 1.09 1 1.18 0.0384 643 6430 TRUE 1.41566877563247 0.086 0.0415 0.218 0.121 0.0717 1.24 0.981 1.58 0.19 0.122 0.119 1.21 0.952 1.54 0.261 0.121 0.0305 1.3 1.02 1.65 ukb-melanoma-latest-gwas all 381 Otitis media and Eustachian tube disorders Sense Organs Both 1.01 0.963 1.05 0.81 2253 22530 FALSE 0.0915149811213502 0.00533 0.0222 -0.0583 0.063 0.354 0.943 0.834 1.07 0.0177 0.062 0.776 1.02 0.901 1.15 -0.0114 0.0628 0.856 0.989 0.874 1.12 ukb-melanoma-latest-gwas all 381.1 Otitis media Sense Organs Both 1.02 0.97 1.07 0.472 1820 18200 FALSE 0.326058001365912 0.0178 0.0247 -0.054 0.0703 0.442 0.947 0.825 1.09 0.024 0.0692 0.729 1.02 0.894 1.17 0.0113 0.0697 0.871 1.01 0.882 1.16 ukb-melanoma-latest-gwas all 381.2 Eustachian tube disorders Sense Organs Both 0.907 0.781 1.05 0.198 191 1910 FALSE 0.703334809738469 -0.0976 0.0759 -0.364 0.211 0.0844 0.695 0.455 1.05 -0.138 0.2 0.491 0.871 0.585 1.29 -0.375 0.214 0.079 0.687 0.448 1.04 ukb-melanoma-latest-gwas all 381.3 Mastoiditis & related conditions Sense Organs Both 0.865 0.739 1.01 0.0689 171 1710 FALSE 1.16178077809237 -0.145 0.0798 -0.16 0.211 0.45 0.852 0.56 1.29 -0.452 0.226 0.046 0.636 0.404 0.992 -0.334 0.223 0.134 0.716 0.458 1.11 ukb-melanoma-latest-gwas all 381.9 Otorrhea Sense Organs Both 1.03 0.908 1.16 0.663 280 2800 FALSE 0.178486471595227 0.0274 0.0627 -0.058 0.181 0.749 0.944 0.659 1.35 0.119 0.175 0.498 1.13 0.797 1.59 0.0873 0.177 0.621 1.09 0.77 1.55 ukb-melanoma-latest-gwas all 381.11 Suppurative and unspecified otitis media Sense Organs Both 1.04 0.97 1.12 0.264 854 8540 FALSE 0.578396073130169 0.0404 0.0361 -0.0332 0.104 0.748 0.967 0.789 1.19 0.0773 0.101 0.445 1.08 0.886 1.32 0.0582 0.102 0.568 1.06 0.867 1.3 ukb-melanoma-latest-gwas all 382 Otalgia Sense Organs Both 1.01 0.9 1.14 0.835 309 3090 FALSE 0.0783135245163979 0.0124 0.0598 0.22 0.17 0.195 1.25 0.893 1.75 0.229 0.17 0.178 1.26 0.901 1.76 0.0584 0.177 0.742 1.06 0.747 1.51 ukb-melanoma-latest-gwas all 383 Otosclerosis Sense Organs Both 1.09 0.971 1.23 0.14 309 3090 FALSE 0.853871964321762 0.0885 0.0599 -0.126 0.174 0.468 0.882 0.625 1.24 0.0502 0.167 0.763 1.05 0.757 1.46 0.104 0.166 0.53 1.11 0.8 1.54 ukb-melanoma-latest-gwas all 384 Other disorders of tympanic membrane Sense Organs Both 0.985 0.931 1.04 0.595 1362 13620 FALSE 0.22548303427145 -0.0151 0.0285 0.0157 0.0807 0.845 1.02 0.867 1.19 0.104 0.0793 0.188 1.11 0.95 1.3 -0.0697 0.0827 0.399 0.933 0.793 1.1 ukb-melanoma-latest-gwas all 384.4 Perforation of tympanic membrane Sense Organs Both 0.991 0.93 1.06 0.789 1043 10430 FALSE 0.10292299679058 -0.00872 0.0326 -0.0177 0.0923 0.848 0.982 0.82 1.18 0.0854 0.0904 0.345 1.09 0.912 1.3 -0.061 0.0938 0.516 0.941 0.782 1.13 ukb-melanoma-latest-gwas all 385 Other disorders of middle ear and mastoid Sense Organs Both 1.04 0.971 1.12 0.241 827 8270 FALSE 0.617982957425132 0.043 0.0367 5.21e-05 0.103 1 1 0.816 1.22 0.0146 0.103 0.887 1.01 0.829 1.24 -0.0161 0.104 0.877 0.984 0.802 1.21 ukb-melanoma-latest-gwas all 385.3 Cholesteatoma Sense Organs Both 1.06 0.979 1.16 0.141 607 6070 FALSE 0.85078088734462 0.0629 0.0428 0.0492 0.12 0.682 1.05 0.83 1.33 -0.0366 0.122 0.765 0.964 0.758 1.23 0.0567 0.12 0.637 1.06 0.836 1.34 ukb-melanoma-latest-gwas all 385.5 Tympanosclerosis and middle ear disease related to otitis media Sense Organs Both 1.03 0.9 1.17 0.687 241 2410 FALSE 0.16304326294045 0.0272 0.0676 -0.187 0.191 0.327 0.829 0.567 1.21 -0.0525 0.185 0.777 0.949 0.658 1.37 -0.0937 0.188 0.618 0.911 0.628 1.32 ukb-melanoma-latest-gwas all 386 Vertiginous syndromes and other disorders of vestibular system Sense Organs Both 1.05 1 1.1 0.0508 1765 17650 FALSE 1.29413628771608 0.0489 0.0251 0.127 0.0708 0.073 1.14 0.988 1.3 0.000458 0.0728 0.995 1 0.867 1.15 0.137 0.0709 0.0537 1.15 0.998 1.32 ukb-melanoma-latest-gwas all 386.1 Meniere's disease Sense Organs Both 1.07 0.98 1.16 0.133 578 5780 FALSE 0.876148359032914 0.0658 0.0438 0.191 0.126 0.129 1.21 0.946 1.55 0.0904 0.129 0.483 1.09 0.85 1.41 0.273 0.124 0.0282 1.31 1.03 1.68 ukb-melanoma-latest-gwas all 386.2 Peripheral or central vertigo Sense Organs Both 1.04 0.937 1.16 0.454 379 3790 FALSE 0.342944147142896 0.0403 0.0538 0.304 0.151 0.0438 1.35 1.01 1.83 0.0905 0.157 0.563 1.09 0.804 1.49 0.0772 0.157 0.624 1.08 0.792 1.47 ukb-melanoma-latest-gwas all 386.3 Labyrinthitis Sense Organs Both 1.05 0.972 1.13 0.225 767 7670 FALSE 0.647817481888638 0.0461 0.038 -0.0448 0.107 0.677 0.956 0.774 1.18 -0.0324 0.107 0.763 0.968 0.784 1.2 0.0445 0.106 0.675 1.05 0.849 1.29 ukb-melanoma-latest-gwas all 386.9 Dizziness and giddiness (Light-headedness and vertigo) Sense Organs Both 1.15 1.01 1.32 0.0346 243 2430 TRUE 1.46092390120722 0.142 0.0674 0.291 0.197 0.14 1.34 0.908 1.98 0.186 0.201 0.354 1.2 0.811 1.8 0.417 0.192 0.03 1.52 1.04 2.23 ukb-melanoma-latest-gwas all 388 Other disorders of ear Sense Organs Both 1.04 0.9 1.2 0.586 202 2020 FALSE 0.232102383981909 0.0402 0.0739 0.169 0.208 0.414 1.18 0.787 1.79 -0.0863 0.22 0.695 0.917 0.592 1.42 0.215 0.207 0.3 1.24 0.824 1.87 ukb-melanoma-latest-gwas all 389 Hearing loss Sense Organs Both 1.04 1.01 1.08 0.00928 4243 42430 TRUE 2.03245202378114 0.0421 0.0162 -0.0296 0.0463 0.522 0.971 0.887 1.06 0.0061 0.0459 0.894 1.01 0.919 1.1 0.0921 0.0453 0.0418 1.1 1 1.2 ukb-melanoma-latest-gwas all 389.1 Sensorineural hearing loss Sense Organs Both 0.984 0.893 1.08 0.738 456 4560 FALSE 0.131943638176958 -0.0164 0.0492 0.00764 0.135 0.955 1.01 0.773 1.31 -0.274 0.145 0.0581 0.76 0.57 1.01 0.0183 0.135 0.892 1.02 0.781 1.33 ukb-melanoma-latest-gwas all 389.2 Conductive hearing loss Sense Organs Both 1.12 1.01 1.23 0.0261 450 4500 TRUE 1.58335949266172 0.11 0.0496 -0.0169 0.146 0.908 0.983 0.737 1.31 0.155 0.141 0.272 1.17 0.885 1.54 0.21 0.14 0.134 1.23 0.937 1.63 ukb-melanoma-latest-gwas all 389.4 Tinnitus Sense Organs Both 1.01 0.919 1.1 0.892 512 5120 FALSE 0.0496351456238769 0.00633 0.0464 -0.0632 0.132 0.632 0.939 0.724 1.22 0.0623 0.128 0.627 1.06 0.827 1.37 -0.0506 0.132 0.702 0.951 0.733 1.23 ukb-melanoma-latest-gwas all 394 Rheumatic disease of the heart valves Circulatory System Both 1.01 0.98 1.04 0.547 4912 49120 FALSE 0.262012673666569 0.00905 0.015 0.0291 0.0426 0.494 1.03 0.947 1.12 0.037 0.0426 0.385 1.04 0.955 1.13 0.0414 0.0427 0.333 1.04 0.959 1.13 ukb-melanoma-latest-gwas all 394.2 Mitral valve disease Circulatory System Both 1 0.963 1.04 0.98 2992 29920 FALSE 0.00877392430750515 -0.000476 0.0193 0.0195 0.0542 0.719 1.02 0.917 1.13 0.00613 0.0545 0.91 1.01 0.904 1.12 0.00943 0.0547 0.863 1.01 0.907 1.12 ukb-melanoma-latest-gwas all 394.3 Aortic valve disease Circulatory System Both 1.04 0.978 1.1 0.228 1283 12830 FALSE 0.642065152999546 0.0354 0.0294 0.0873 0.0834 0.295 1.09 0.927 1.29 0.0388 0.0843 0.645 1.04 0.881 1.23 0.113 0.0835 0.177 1.12 0.95 1.32 ukb-melanoma-latest-gwas all 394.7 Disease of tricuspid valve Circulatory System Both 1.05 0.986 1.12 0.125 1054 10540 FALSE 0.903089986991944 0.0498 0.0324 -0.025 0.0939 0.79 0.975 0.811 1.17 0.0668 0.092 0.468 1.07 0.892 1.28 0.131 0.091 0.149 1.14 0.954 1.36 ukb-melanoma-latest-gwas all 395 Heart valve disorders Circulatory System Both 1.01 0.977 1.04 0.622 4249 42490 FALSE 0.206209615309181 0.00796 0.0162 0.0191 0.0455 0.675 1.02 0.932 1.11 -0.0168 0.0459 0.715 0.983 0.899 1.08 0.0279 0.0457 0.541 1.03 0.94 1.12 ukb-melanoma-latest-gwas all 395.1 Nonrheumatic mitral valve disorders Circulatory System Both 0.993 0.956 1.03 0.722 2892 28920 FALSE 0.141462802430361 -0.00698 0.0196 0.0177 0.055 0.747 1.02 0.914 1.13 -0.0182 0.0555 0.743 0.982 0.881 1.09 -0.000786 0.0555 0.989 0.999 0.896 1.11 ukb-melanoma-latest-gwas all 395.2 Nonrheumatic aortic valve disorders Circulatory System Both 0.901 0.797 1.02 0.0958 278 2780 FALSE 1.01863449092146 -0.104 0.0627 -0.0174 0.169 0.918 0.983 0.704 1.37 -0.295 0.181 0.103 0.745 0.52 1.06 -0.176 0.176 0.316 0.839 0.592 1.18 ukb-melanoma-latest-gwas all 395.3 Nonrheumatic tricuspid valve disorders Circulatory System Both 1.1 0.9 1.35 0.346 104 1040 FALSE 0.460923901207223 0.0966 0.102 0.158 0.285 0.579 1.17 0.665 2.08 -0.32 0.32 0.317 0.726 0.377 1.37 0.344 0.278 0.215 1.41 0.817 2.47 ukb-melanoma-latest-gwas all 395.4 Nonrheumatic pulmonary valve disorders Circulatory System Both 0.991 0.803 1.22 0.932 96 960 FALSE 0.0305840876460186 -0.00905 0.106 -0.0595 0.296 0.841 0.942 0.52 1.7 0.087 0.291 0.765 1.09 0.611 1.95 -0.175 0.302 0.564 0.84 0.457 1.53 ukb-melanoma-latest-gwas all 395.6 Heart valve replaced Circulatory System Both 1.06 1 1.12 0.0409 1494 14940 TRUE 1.38827669199266 0.0556 0.0272 0.18 0.0776 0.0206 1.2 1.03 1.39 0.0715 0.0793 0.368 1.07 0.919 1.26 0.178 0.078 0.0224 1.19 1.03 1.39 ukb-melanoma-latest-gwas all 396 Abnormal heart sounds Circulatory System Both 0.989 0.928 1.05 0.726 1049 10490 FALSE 0.139063379299906 -0.0114 0.0325 -0.0562 0.0917 0.54 0.945 0.789 1.13 0.0273 0.0901 0.761 1.03 0.861 1.23 -0.0668 0.0924 0.47 0.935 0.78 1.12 ukb-melanoma-latest-gwas all 401 Hypertension Circulatory System Both 1.02 1.01 1.03 2.59e-06 74203 267481 TRUE 5.58670023591875 0.0203 0.00432 0.0375 0.0123 0.00224 1.04 1.01 1.06 0.0514 0.0122 2.69e-05 1.05 1.03 1.08 0.0555 0.0123 6.08e-06 1.06 1.03 1.08 ukb-melanoma-latest-gwas all 401.1 Essential hypertension Circulatory System Both 1.02 1.01 1.03 3.78e-06 73892 266307 TRUE 5.42250820016277 0.02 0.00433 0.0369 0.0123 0.00264 1.04 1.01 1.06 0.052 0.0123 2.24e-05 1.05 1.03 1.08 0.0547 0.0123 8.61e-06 1.06 1.03 1.08 ukb-melanoma-latest-gwas all 401.2 Hypertensive heart and/or renal disease Circulatory System Both 1.08 1.03 1.13 0.00253 1910 19099 TRUE 2.59687947882418 0.0729 0.0241 0.118 0.0703 0.0943 1.12 0.98 1.29 0.183 0.0696 0.00849 1.2 1.05 1.38 0.239 0.0691 0.000552 1.27 1.11 1.45 ukb-melanoma-latest-gwas all 401.3 Other hypertensive complications Circulatory System Both 1.07 0.9 1.27 0.444 144 1440 FALSE 0.35261702988538 0.0669 0.0873 0.149 0.252 0.553 1.16 0.705 1.92 0.376 0.242 0.12 1.46 0.906 2.37 0.0599 0.26 0.818 1.06 0.633 1.78 ukb-melanoma-latest-gwas all 401.21 Hypertensive heart disease Circulatory System Both 1.03 0.924 1.15 0.605 370 3700 FALSE 0.218244625347531 0.0282 0.0546 0.0987 0.154 0.522 1.1 0.815 1.5 0.0511 0.156 0.743 1.05 0.774 1.43 0.121 0.156 0.439 1.13 0.831 1.53 ukb-melanoma-latest-gwas all 401.22 Hypertensive chronic kidney disease Circulatory System Both 1.08 1.03 1.14 0.00317 1551 15510 TRUE 2.49894073778225 0.0791 0.0268 0.0908 0.0787 0.248 1.1 0.938 1.28 0.212 0.0769 0.00591 1.24 1.06 1.44 0.246 0.0766 0.00131 1.28 1.1 1.49 ukb-melanoma-latest-gwas all 402 Elevated blood pressure reading without diagnosis of hypertension Circulatory System Both 0.996 0.944 1.05 0.891 1481 14810 FALSE 0.0501222959631252 -0.00375 0.0274 0.0408 0.0776 0.599 1.04 0.894 1.21 0.0697 0.0771 0.366 1.07 0.922 1.25 0.0173 0.0783 0.826 1.02 0.872 1.19 ukb-melanoma-latest-gwas all 411 Ischemic Heart Disease Circulatory System Both 1.01 1 1.03 0.0256 31407 211307 TRUE 1.59176003468815 0.0137 0.00615 0.0229 0.0174 0.188 1.02 0.989 1.06 0.0412 0.0174 0.0178 1.04 1.01 1.08 0.0397 0.0175 0.0228 1.04 1.01 1.08 ukb-melanoma-latest-gwas all 411.1 Unstable angina (intermediate coronary syndrome) Circulatory System Both 1.03 1 1.06 0.0388 5161 51604 TRUE 1.41116827440579 0.0303 0.0147 -0.0156 0.0419 0.709 0.985 0.907 1.07 0.0407 0.0414 0.326 1.04 0.96 1.13 0.0576 0.0414 0.164 1.06 0.977 1.15 ukb-melanoma-latest-gwas all 411.2 Myocardial infarction Circulatory System Both 1.02 0.997 1.04 0.0954 11981 112940 FALSE 1.0204516252959 0.0161 0.00966 0.0302 0.0275 0.272 1.03 0.977 1.09 0.0496 0.0274 0.0698 1.05 0.996 1.11 0.0527 0.0274 0.0547 1.05 0.999 1.11 ukb-melanoma-latest-gwas all 411.3 Angina pectoris Circulatory System Both 1.04 1.02 1.06 6.19e-06 15926 144026 TRUE 5.20830935097988 0.038 0.0084 0.0408 0.0241 0.0899 1.04 0.994 1.09 0.0804 0.0239 0.000759 1.08 1.03 1.14 0.0957 0.0239 6.12e-05 1.1 1.05 1.15 ukb-melanoma-latest-gwas all 411.4 Coronary atherosclerosis Circulatory System Both 1.01 0.999 1.03 0.0707 20207 154941 FALSE 1.1505805862031 0.0137 0.00755 0.0123 0.0215 0.566 1.01 0.971 1.06 0.0443 0.0213 0.0381 1.05 1 1.09 0.0396 0.0214 0.0645 1.04 0.998 1.09 ukb-melanoma-latest-gwas all 411.8 Other chronic ischemic heart disease, unspecified Circulatory System Both 1.02 1.01 1.04 0.00765 15331 132062 TRUE 2.11633856484638 0.0229 0.00859 0.0215 0.0244 0.379 1.02 0.974 1.07 0.0475 0.0243 0.0507 1.05 1 1.1 0.0529 0.0244 0.0301 1.05 1.01 1.11 ukb-melanoma-latest-gwas all 411.9 Other acute and subacute forms of ischemic heart disease Circulatory System Both 0.968 0.912 1.03 0.281 1218 12180 FALSE 0.55129368009492 -0.0325 0.0301 -0.0154 0.0837 0.854 0.985 0.835 1.16 -0.119 0.0858 0.167 0.888 0.75 1.05 -0.0167 0.0844 0.843 0.983 0.833 1.16 ukb-melanoma-latest-gwas all 411.41 Aneurysm and dissection of heart Circulatory System Both 0.993 0.919 1.07 0.859 701 7010 FALSE 0.0660068361687577 -0.00704 0.0397 0.116 0.11 0.295 1.12 0.904 1.39 0.00522 0.113 0.963 1.01 0.805 1.26 -0.049 0.115 0.669 0.952 0.76 1.19 ukb-melanoma-latest-gwas all 414 Other forms of chronic heart disease Circulatory System Both 0.995 0.948 1.04 0.833 1827 18270 FALSE 0.0793549985932124 -0.0052 0.0246 0.154 0.0694 0.0262 1.17 1.02 1.34 0.119 0.0699 0.0889 1.13 0.982 1.29 0.0128 0.0719 0.859 1.01 0.88 1.17 ukb-melanoma-latest-gwas all 414.2 ASCVD Circulatory System Both 0.996 0.776 1.27 0.971 72 720 FALSE 0.0127807700919951 -0.00451 0.123 0.0907 0.326 0.781 1.09 0.572 2.11 -0.315 0.364 0.387 0.73 0.345 1.51 -0.00702 0.338 0.983 0.993 0.504 1.95 ukb-melanoma-latest-gwas all 415 Pulmonary heart disease Circulatory System Both 0.977 0.948 1.01 0.144 4531 45310 FALSE 0.84163750790475 -0.0229 0.0156 -0.0256 0.0438 0.56 0.975 0.894 1.06 -0.0213 0.0439 0.627 0.979 0.898 1.07 -0.064 0.0444 0.149 0.938 0.86 1.02 ukb-melanoma-latest-gwas all 415.1 Acute pulmonary heart disease Circulatory System Both 1.03 0.809 1.31 0.821 75 750 FALSE 0.0856568428805593 0.0272 0.12 -0.154 0.334 0.645 0.857 0.435 1.67 -0.123 0.338 0.716 0.884 0.445 1.74 0.0975 0.324 0.763 1.1 0.577 2.11 ukb-melanoma-latest-gwas all 415.2 Chronic pulmonary heart disease Circulatory System Both 1.01 0.93 1.1 0.788 602 6020 FALSE 0.103473782510445 0.0115 0.0428 0.0245 0.121 0.84 1.02 0.808 1.3 0.0811 0.12 0.498 1.08 0.857 1.37 -0.0398 0.123 0.747 0.961 0.754 1.22 ukb-melanoma-latest-gwas all 415.11 Pulmonary embolism and infarction, acute Circulatory System Both 1.03 0.809 1.31 0.821 75 750 FALSE 0.0856568428805593 0.0272 0.12 -0.154 0.334 0.645 0.857 0.435 1.67 -0.123 0.338 0.716 0.884 0.445 1.74 0.0975 0.324 0.763 1.1 0.577 2.11 ukb-melanoma-latest-gwas all 415.21 Primary pulmonary hypertension Circulatory System Both 1.02 0.927 1.13 0.656 447 4470 FALSE 0.18309616062434 0.0221 0.0496 0.0813 0.142 0.566 1.08 0.821 1.43 0.177 0.139 0.202 1.19 0.909 1.57 -0.013 0.145 0.928 0.987 0.742 1.31 ukb-melanoma-latest-gwas all 416 Cardiomegaly Circulatory System Both 1.02 0.977 1.06 0.401 2686 26860 FALSE 0.396855627379818 0.0171 0.0203 0.116 0.0573 0.0427 1.12 1 1.26 0.0324 0.0584 0.579 1.03 0.921 1.16 0.0701 0.0581 0.227 1.07 0.957 1.2 ukb-melanoma-latest-gwas all 418 Nonspecific chest pain Circulatory System Both 1.01 0.999 1.02 0.0817 28677 270690 FALSE 1.08777794346758 0.0109 0.00624 0.0261 0.0177 0.14 1.03 0.991 1.06 0.0334 0.0177 0.0594 1.03 0.999 1.07 0.0345 0.0177 0.0515 1.04 1 1.07 ukb-melanoma-latest-gwas all 418.1 Precordial pain Circulatory System Both 1.03 0.994 1.06 0.109 3567 35670 FALSE 0.962573502059376 0.0283 0.0176 0.00457 0.0501 0.927 1 0.911 1.11 -0.0104 0.0503 0.836 0.99 0.897 1.09 0.0675 0.0496 0.173 1.07 0.971 1.18 ukb-melanoma-latest-gwas all 420 Carditis Circulatory System Both 1.05 1 1.1 0.0365 2146 21460 TRUE 1.43770713554353 0.0476 0.0228 -0.136 0.0657 0.0379 0.872 0.767 0.992 -0.0227 0.064 0.722 0.978 0.862 1.11 0.0783 0.0628 0.213 1.08 0.956 1.22 ukb-melanoma-latest-gwas all 420.1 Myocarditis Circulatory System Both 0.973 0.811 1.17 0.769 127 1270 FALSE 0.114073660198569 -0.0271 0.0922 -0.322 0.273 0.238 0.725 0.417 1.24 0.0965 0.246 0.695 1.1 0.676 1.8 -0.0833 0.258 0.747 0.92 0.549 1.54 ukb-melanoma-latest-gwas all 420.2 Pericarditis Circulatory System Both 1.03 0.974 1.09 0.296 1346 13460 FALSE 0.528708288941061 0.03 0.0287 -0.134 0.0821 0.104 0.875 0.745 1.03 -0.0625 0.0807 0.439 0.939 0.802 1.1 0.049 0.0792 0.536 1.05 0.899 1.23 ukb-melanoma-latest-gwas all 420.3 Endocarditis Circulatory System Both 1.1 1.02 1.19 0.0186 719 7190 TRUE 1.73048705578208 0.0928 0.0394 -0.0712 0.114 0.533 0.931 0.744 1.17 0.00624 0.112 0.956 1.01 0.807 1.25 0.169 0.109 0.12 1.18 0.957 1.47 ukb-melanoma-latest-gwas all 420.21 Acute pericarditis Circulatory System Both 0.984 0.858 1.13 0.823 224 2240 FALSE 0.0846001647877302 -0.0157 0.07 0.0712 0.195 0.715 1.07 0.73 1.58 -0.000221 0.197 0.999 1 0.676 1.48 0.0079 0.199 0.968 1.01 0.68 1.49 ukb-melanoma-latest-gwas all 420.22 Chronic pericarditis Circulatory System Both 1.16 0.956 1.41 0.129 113 1130 FALSE 0.889410289700751 0.149 0.0979 -0.26 0.295 0.379 0.771 0.424 1.39 0.212 0.273 0.439 1.24 0.72 2.14 0.234 0.271 0.389 1.26 0.739 2.18 ukb-melanoma-latest-gwas all 425 Cardiomyopathy Circulatory System Both 0.976 0.921 1.03 0.409 1277 12770 FALSE 0.388276691992658 -0.0243 0.0294 0.0148 0.082 0.857 1.01 0.864 1.19 -0.0226 0.0827 0.784 0.978 0.831 1.15 -0.0834 0.0842 0.322 0.92 0.78 1.09 ukb-melanoma-latest-gwas all 425.1 Primary/intrinsic cardiomyopathies Circulatory System Both 0.982 0.926 1.04 0.541 1238 12380 FALSE 0.266802734893431 -0.0183 0.0299 0.0624 0.0832 0.453 1.06 0.904 1.25 0.00506 0.0843 0.952 1.01 0.852 1.19 -0.069 0.0861 0.423 0.933 0.788 1.11 ukb-melanoma-latest-gwas all 425.8 Other cardiomyopathy Circulatory System Both 0.86 0.656 1.13 0.266 60 600 FALSE 0.575118363368933 -0.15 0.135 -0.235 0.36 0.513 0.79 0.38 1.62 -0.23 0.362 0.525 0.794 0.379 1.63 -0.363 0.374 0.332 0.696 0.324 1.46 ukb-melanoma-latest-gwas all 425.11 Hypertrophic obstructive cardiomyopathy Circulatory System Both 1.05 0.877 1.26 0.596 132 1320 FALSE 0.224753740259764 0.0483 0.0909 0.471 0.256 0.066 1.6 0.969 2.69 0.2 0.271 0.461 1.22 0.713 2.11 0.222 0.269 0.409 1.25 0.734 2.14 ukb-melanoma-latest-gwas all 425.12 Other hypertrophic cardiomyopathy Circulatory System Both 0.871 0.742 1.02 0.0883 164 1640 FALSE 1.05403929642243 -0.138 0.0811 0.123 0.215 0.567 1.13 0.74 1.74 -0.182 0.23 0.429 0.833 0.526 1.31 -0.307 0.239 0.198 0.736 0.455 1.18 ukb-melanoma-latest-gwas all 426 Cardiac conduction disorders Circulatory System Both 1.02 0.996 1.05 0.0996 6937 69370 FALSE 1.0017406615763 0.0208 0.0127 0.0205 0.036 0.569 1.02 0.951 1.1 0.0499 0.0358 0.163 1.05 0.98 1.13 0.0474 0.0359 0.187 1.05 0.977 1.13 ukb-melanoma-latest-gwas all 426.2 Atrioventricular [AV] block Circulatory System Both 1.02 0.98 1.07 0.284 2126 21259 FALSE 0.546681659952962 0.0245 0.0228 0.0953 0.0648 0.141 1.1 0.969 1.25 0.109 0.0648 0.0922 1.12 0.982 1.27 0.0441 0.0659 0.504 1.05 0.918 1.19 ukb-melanoma-latest-gwas all 426.3 Bundle branch block Circulatory System Both 1.01 0.976 1.05 0.522 3344 33440 FALSE 0.282329496997738 0.0116 0.0182 0.0586 0.0514 0.254 1.06 0.959 1.17 0.0363 0.0518 0.484 1.04 0.937 1.15 0.0397 0.0518 0.443 1.04 0.94 1.15 ukb-melanoma-latest-gwas all 426.4 Anomalous atrioventricular excitation Circulatory System Both 0.992 0.867 1.14 0.911 233 2330 FALSE 0.0404816230270017 -0.00768 0.0686 0.0312 0.194 0.872 1.03 0.703 1.52 0.0479 0.194 0.805 1.05 0.716 1.54 0.0622 0.195 0.75 1.06 0.724 1.57 ukb-melanoma-latest-gwas all 426.8 Other cardiac conduction disorders Circulatory System Both 1.02 0.779 1.33 0.903 60 600 FALSE 0.0443122496864942 0.0163 0.134 -0.645 0.391 0.0988 0.525 0.232 1.13 -0.595 0.377 0.114 0.551 0.251 1.15 -0.0885 0.337 0.793 0.915 0.467 1.79 ukb-melanoma-latest-gwas all 426.9 Cardiac pacemaker/device in situ Circulatory System Both 1.05 1.01 1.09 0.0208 2485 24848 TRUE 1.68193666503724 0.0489 0.0211 0.0236 0.0611 0.699 1.02 0.908 1.15 0.138 0.0597 0.0204 1.15 1.02 1.29 0.108 0.0604 0.0724 1.11 0.99 1.25 ukb-melanoma-latest-gwas all 426.21 First degree AV block Circulatory System Both 1.02 0.955 1.09 0.551 989 9890 FALSE 0.258848401148215 0.0199 0.0334 0.0619 0.0943 0.511 1.06 0.884 1.28 0.0156 0.0953 0.87 1.02 0.842 1.22 0.0426 0.095 0.654 1.04 0.866 1.26 ukb-melanoma-latest-gwas all 426.23 Second degree AV block Circulatory System Both 1.04 0.946 1.15 0.4 453 4530 FALSE 0.397940008672038 0.0416 0.0494 0.12 0.141 0.393 1.13 0.855 1.49 0.124 0.141 0.379 1.13 0.857 1.5 0.0993 0.142 0.485 1.1 0.835 1.46 ukb-melanoma-latest-gwas all 426.24 Atrioventricular block, complete Circulatory System Both 1.02 0.936 1.11 0.655 588 5871 FALSE 0.183758700008217 0.0194 0.0434 0.131 0.124 0.289 1.14 0.894 1.46 0.204 0.122 0.0947 1.23 0.965 1.56 0.0505 0.127 0.691 1.05 0.819 1.35 ukb-melanoma-latest-gwas all 426.25 Other heart block Circulatory System Both 0.972 0.811 1.16 0.751 132 1320 FALSE 0.124360062995832 -0.0289 0.091 0.235 0.249 0.345 1.26 0.775 2.08 -0.0202 0.268 0.94 0.98 0.574 1.67 -0.0186 0.264 0.944 0.982 0.58 1.66 ukb-melanoma-latest-gwas all 426.31 Right bundle branch block Circulatory System Both 1.03 0.98 1.09 0.217 1496 14960 FALSE 0.66354026615147 0.0337 0.0272 0.123 0.0773 0.111 1.13 0.972 1.32 0.0927 0.078 0.235 1.1 0.942 1.28 0.0951 0.0781 0.223 1.1 0.944 1.28 ukb-melanoma-latest-gwas all 426.32 Left bundle branch block Circulatory System Both 1.01 0.961 1.06 0.715 1753 17530 FALSE 0.145693958198919 0.00917 0.0251 0.0442 0.0713 0.535 1.05 0.909 1.2 0.0578 0.0713 0.417 1.06 0.921 1.22 0.0473 0.0715 0.509 1.05 0.911 1.21 ukb-melanoma-latest-gwas all 426.91 Cardiac pacemaker in situ Circulatory System Both 1.05 1 1.1 0.0312 2281 22806 TRUE 1.50584540598156 0.0476 0.0221 0.0412 0.0635 0.516 1.04 0.92 1.18 0.137 0.0623 0.0284 1.15 1.01 1.3 0.0977 0.0632 0.122 1.1 0.974 1.25 ukb-melanoma-latest-gwas all 427 Cardiac dysrhythmias Circulatory System Both 1.01 0.996 1.02 0.179 24341 206836 FALSE 0.747146969020107 0.00917 0.00682 0.038 0.0193 0.049 1.04 1 1.08 0.0358 0.0193 0.0639 1.04 0.998 1.08 0.0262 0.0194 0.177 1.03 0.988 1.07 ukb-melanoma-latest-gwas all 427.1 Paroxysmal tachycardia, unspecified Circulatory System Both 0.999 0.963 1.04 0.95 3219 32190 FALSE 0.0222763947111523 -0.00116 0.0186 0.0496 0.052 0.34 1.05 0.949 1.16 -0.013 0.0528 0.806 0.987 0.89 1.09 -0.00705 0.0529 0.894 0.993 0.895 1.1 ukb-melanoma-latest-gwas all 427.2 Atrial fibrillation and flutter Circulatory System Both 1.01 0.99 1.02 0.409 14669 133702 FALSE 0.388276691992658 0.00722 0.00875 0.0235 0.0247 0.342 1.02 0.975 1.07 0.0275 0.0247 0.266 1.03 0.979 1.08 0.0172 0.0249 0.489 1.02 0.969 1.07 ukb-melanoma-latest-gwas all 427.3 Other specified cardiac dysrhythmias Circulatory System Both 1.01 0.974 1.05 0.578 3234 32340 FALSE 0.238072161579471 0.0103 0.0185 0.0444 0.0526 0.399 1.05 0.943 1.16 0.0659 0.0524 0.208 1.07 0.964 1.18 0.0423 0.0529 0.424 1.04 0.94 1.16 ukb-melanoma-latest-gwas all 427.4 Cardiac arrest and ventricular fibrillation Circulatory System Both 1.02 0.96 1.08 0.541 1200 12000 FALSE 0.266802734893431 0.0186 0.0304 -0.005 0.0861 0.954 0.995 0.84 1.18 0.00282 0.086 0.974 1 0.847 1.19 0.0453 0.0857 0.597 1.05 0.884 1.24 ukb-melanoma-latest-gwas all 427.5 Arrhythmia (cardiac) NOS Circulatory System Both 1.03 0.961 1.1 0.435 957 9570 FALSE 0.361510743045363 0.0266 0.034 0.00843 0.0964 0.93 1.01 0.834 1.22 0.00646 0.0965 0.947 1.01 0.833 1.22 0.0589 0.0959 0.539 1.06 0.879 1.28 ukb-melanoma-latest-gwas all 427.6 Premature beats Circulatory System Both 1.08 0.988 1.18 0.0883 536 5360 FALSE 1.05403929642243 0.0779 0.0457 0.148 0.133 0.267 1.16 0.892 1.51 0.188 0.132 0.155 1.21 0.931 1.57 0.309 0.13 0.0176 1.36 1.06 1.76 ukb-melanoma-latest-gwas all 427.7 Tachycardia NOS Circulatory System Both 0.995 0.952 1.04 0.814 2191 21899 FALSE 0.0893755951107988 -0.00529 0.0225 0.0488 0.0634 0.442 1.05 0.927 1.19 0.0583 0.0633 0.357 1.06 0.936 1.2 -0.00752 0.0645 0.907 0.993 0.874 1.13 ukb-melanoma-latest-gwas all 427.8 Sinoatrial node dysfunction (Bradycardia) Circulatory System Both 0.999 0.902 1.11 0.99 403 4030 FALSE 0.00436480540245009 -0.000649 0.0524 0.0145 0.15 0.923 1.01 0.755 1.36 0.23 0.143 0.108 1.26 0.95 1.67 -0.0882 0.154 0.567 0.916 0.675 1.24 ukb-melanoma-latest-gwas all 427.9 Palpitations Circulatory System Both 1.04 1 1.07 0.041 3816 38155 TRUE 1.38721614328026 0.0349 0.0171 0.0248 0.0486 0.61 1.03 0.932 1.13 0.0131 0.0488 0.788 1.01 0.921 1.11 0.0995 0.048 0.0381 1.1 1.01 1.21 ukb-melanoma-latest-gwas all 427.11 Paroxysmal supraventricular tachycardia Circulatory System Both 1.01 0.964 1.05 0.796 2353 23530 FALSE 0.0990869322623309 0.00563 0.0217 0.0175 0.0611 0.774 1.02 0.903 1.15 -0.0138 0.0616 0.823 0.986 0.874 1.11 0.012 0.0615 0.845 1.01 0.897 1.14 ukb-melanoma-latest-gwas all 427.12 Paroxysmal ventricular tachycardia Circulatory System Both 1.02 0.953 1.09 0.575 938 9380 FALSE 0.24033215531037 0.0193 0.0344 0.105 0.0967 0.276 1.11 0.919 1.34 0.019 0.0986 0.847 1.02 0.84 1.24 0.0673 0.0979 0.492 1.07 0.883 1.3 ukb-melanoma-latest-gwas all 427.41 Ventricular fibrillation and flutter Circulatory System Both 1.01 0.901 1.12 0.912 344 3440 FALSE 0.0400051616715838 0.00627 0.0564 0.0649 0.16 0.685 1.07 0.779 1.46 0.0203 0.162 0.9 1.02 0.742 1.4 0.0966 0.159 0.544 1.1 0.805 1.51 ukb-melanoma-latest-gwas all 427.42 Cardiac arrest Circulatory System Both 1.01 0.945 1.08 0.793 991 9910 FALSE 0.100726812682396 0.00878 0.0335 -0.0426 0.0945 0.652 0.958 0.796 1.15 -0.026 0.0943 0.783 0.974 0.809 1.17 0.0206 0.0939 0.826 1.02 0.849 1.23 ukb-melanoma-latest-gwas all 427.61 Supraventricular premature beats Circulatory System Both 1.03 0.85 1.25 0.771 117 1169 FALSE 0.112945621949043 0.0281 0.0963 -0.244 0.278 0.38 0.783 0.447 1.36 -0.0229 0.265 0.931 0.977 0.576 1.66 0.0823 0.262 0.753 1.09 0.646 1.83 ukb-melanoma-latest-gwas all 428 Congestive heart failure; nonhypertensive Circulatory System Both 1.01 0.981 1.04 0.532 5621 56168 FALSE 0.274088367704952 0.00879 0.0141 0.0456 0.0398 0.251 1.05 0.968 1.13 0.0367 0.0399 0.357 1.04 0.959 1.12 0.0354 0.0401 0.377 1.04 0.958 1.12 ukb-melanoma-latest-gwas all 428.1 Congestive heart failure (CHF) NOS Circulatory System Both 1.01 0.964 1.05 0.72 2106 21052 FALSE 0.142667503568732 0.00824 0.023 0.0743 0.0644 0.249 1.08 0.949 1.22 -0.00664 0.0656 0.919 0.993 0.873 1.13 0.0381 0.0653 0.559 1.04 0.914 1.18 ukb-melanoma-latest-gwas all 428.2 Heart failure NOS Circulatory System Both 1 0.973 1.04 0.803 4457 44528 FALSE 0.095284454721319 0.00394 0.0158 0.0476 0.0447 0.286 1.05 0.961 1.14 0.0453 0.0447 0.311 1.05 0.959 1.14 0.0286 0.0451 0.526 1.03 0.942 1.12 ukb-melanoma-latest-gwas all 429 Ill-defined descriptions and complications of heart disease Circulatory System Both 0.994 0.921 1.07 0.873 734 7340 FALSE 0.0589857562944303 -0.0062 0.0388 -0.0424 0.109 0.699 0.959 0.773 1.19 0.0346 0.108 0.747 1.04 0.838 1.28 -0.104 0.111 0.353 0.902 0.724 1.12 ukb-melanoma-latest-gwas all 429.2 Abnormal function study of cardiovascular system Circulatory System Both 1 0.918 1.1 0.926 524 5240 FALSE 0.0333890133180656 0.00428 0.0459 -0.0139 0.13 0.914 0.986 0.764 1.27 0.0617 0.128 0.629 1.06 0.828 1.37 -0.0649 0.132 0.623 0.937 0.722 1.21 ukb-melanoma-latest-gwas all 429.3 Symptoms involving cardiovascular system Circulatory System Both 0.974 0.841 1.13 0.72 198 1980 FALSE 0.142667503568732 -0.0267 0.0745 -0.1 0.208 0.63 0.905 0.599 1.36 0.0156 0.205 0.939 1.02 0.677 1.52 -0.163 0.213 0.446 0.85 0.556 1.29 ukb-melanoma-latest-gwas all 430 Intracranial hemorrhage Circulatory System Both 0.995 0.949 1.04 0.841 1908 19080 FALSE 0.0752040042020878 -0.00483 0.0241 0.00226 0.0675 0.973 1 0.878 1.14 -0.0754 0.0688 0.273 0.927 0.81 1.06 0.0149 0.0677 0.826 1.02 0.889 1.16 ukb-melanoma-latest-gwas all 430.1 Subarachnoid hemorrhage Circulatory System Both 1.01 0.94 1.08 0.814 855 8550 FALSE 0.0893755951107988 0.00848 0.036 0.154 0.101 0.13 1.17 0.956 1.42 0.0487 0.104 0.639 1.05 0.856 1.29 0.0764 0.104 0.461 1.08 0.881 1.32 ukb-melanoma-latest-gwas all 430.2 Intracerebral hemorrhage Circulatory System Both 1.02 0.95 1.1 0.535 769 7690 FALSE 0.271646217978772 0.0236 0.038 0.0358 0.107 0.739 1.04 0.839 1.28 -0.0143 0.109 0.895 0.986 0.796 1.22 0.0909 0.106 0.393 1.1 0.889 1.35 ukb-melanoma-latest-gwas all 430.3 Subdural hemorrhage Circulatory System Both 0.883 0.778 1 0.0543 267 2670 FALSE 1.26520017041115 -0.124 0.0644 -0.241 0.173 0.163 0.785 0.557 1.1 -0.33 0.177 0.0617 0.719 0.506 1.02 -0.379 0.18 0.0351 0.685 0.479 0.974 ukb-melanoma-latest-gwas all 433 Cerebrovascular disease Circulatory System Both 1.03 1.01 1.05 0.00858 8804 87981 TRUE 2.06651271215129 0.0295 0.0112 0.0838 0.0321 0.00893 1.09 1.02 1.16 0.0855 0.0321 0.00776 1.09 1.02 1.16 0.106 0.0321 0.001 1.11 1.04 1.18 ukb-melanoma-latest-gwas all 433.1 Occlusion and stenosis of precerebral arteries Circulatory System Both 1.08 1.02 1.15 0.00978 1187 11848 TRUE 2.0096611452124 0.079 0.0306 0.121 0.0893 0.174 1.13 0.948 1.35 0.139 0.0891 0.12 1.15 0.964 1.37 0.278 0.0869 0.00137 1.32 1.11 1.57 ukb-melanoma-latest-gwas all 433.2 Occlusion of cerebral arteries Circulatory System Both 1.02 0.992 1.06 0.144 4244 42423 FALSE 0.84163750790475 0.0237 0.0162 0.0682 0.0462 0.14 1.07 0.978 1.17 0.0734 0.0462 0.112 1.08 0.983 1.18 0.11 0.046 0.0174 1.12 1.02 1.22 ukb-melanoma-latest-gwas all 433.3 Cerebral ischemia Circulatory System Both 1.04 1 1.08 0.0378 2920 29192 TRUE 1.42250820016277 0.0405 0.0195 0.123 0.0552 0.0263 1.13 1.01 1.26 0.0576 0.0561 0.304 1.06 0.949 1.18 0.109 0.0557 0.0498 1.12 1 1.24 ukb-melanoma-latest-gwas all 433.5 Cerebral aneurysm Circulatory System Both 1.02 0.918 1.13 0.722 391 3909 FALSE 0.141462802430361 0.0189 0.0531 0.358 0.151 0.0175 1.43 1.07 1.93 0.189 0.156 0.224 1.21 0.89 1.65 0.154 0.158 0.328 1.17 0.856 1.59 ukb-melanoma-latest-gwas all 433.8 Late effects of cerebrovascular disease Circulatory System Both 1 0.948 1.06 0.876 1270 12693 FALSE 0.0574958938319193 0.0046 0.0295 0.0117 0.0843 0.89 1.01 0.857 1.19 0.0589 0.0835 0.48 1.06 0.9 1.25 0.0474 0.0838 0.572 1.05 0.89 1.24 ukb-melanoma-latest-gwas all 433.12 Cerebral atherosclerosis Circulatory System Both 1.07 0.934 1.23 0.32 227 2270 FALSE 0.494850021680094 0.0692 0.0696 0.203 0.199 0.309 1.22 0.827 1.82 0.163 0.201 0.416 1.18 0.793 1.76 0.15 0.201 0.456 1.16 0.781 1.73 ukb-melanoma-latest-gwas all 433.21 Cerebral artery occlusion, with cerebral infarction Circulatory System Both 0.992 0.943 1.04 0.757 1685 16840 FALSE 0.120904120499927 -0.00794 0.0256 0.0788 0.0723 0.276 1.08 0.939 1.25 0.056 0.0727 0.441 1.06 0.917 1.22 0.0216 0.0736 0.769 1.02 0.884 1.18 ukb-melanoma-latest-gwas all 433.31 Transient cerebral ischemia Circulatory System Both 1.03 0.982 1.07 0.236 2132 21312 FALSE 0.627087997029893 0.027 0.0228 0.102 0.064 0.109 1.11 0.977 1.26 -0.00695 0.0656 0.916 0.993 0.873 1.13 0.0594 0.0649 0.36 1.06 0.934 1.21 ukb-melanoma-latest-gwas all 440 Atherosclerosis Circulatory System Both 1.03 0.974 1.09 0.296 1390 13890 FALSE 0.528708288941061 0.0295 0.0283 0.0694 0.0808 0.39 1.07 0.915 1.26 0.0885 0.0805 0.272 1.09 0.933 1.28 0.116 0.0806 0.15 1.12 0.959 1.32 ukb-melanoma-latest-gwas all 440.1 Atherosclerosis of renal artery Circulatory System Both 1.17 0.964 1.42 0.108 113 1128 FALSE 0.96657624451305 0.158 0.0983 -0.0215 0.304 0.944 0.979 0.531 1.8 0.531 0.277 0.0548 1.7 0.99 2.98 0.358 0.283 0.206 1.43 0.818 2.54 ukb-melanoma-latest-gwas all 440.2 Atherosclerosis of the extremities Circulatory System Both 1.06 0.99 1.14 0.0913 811 8105 FALSE 1.0395292224657 0.0625 0.037 0.184 0.106 0.0837 1.2 0.976 1.48 0.0999 0.108 0.356 1.11 0.894 1.37 0.245 0.106 0.0204 1.28 1.04 1.57 ukb-melanoma-latest-gwas all 440.9 Atherosclerosis of aorta Circulatory System Both 1 0.887 1.13 0.979 286 2860 FALSE 0.00921730819686218 0.00162 0.062 -0.00468 0.175 0.979 0.995 0.704 1.41 0.00879 0.175 0.96 1.01 0.715 1.42 0.0349 0.175 0.842 1.04 0.733 1.46 ukb-melanoma-latest-gwas all 441 Vascular insufficiency of intestine Circulatory System Both 1.07 0.986 1.16 0.104 620 6200 FALSE 0.98296666070122 0.0688 0.0424 0.182 0.122 0.135 1.2 0.945 1.53 0.18 0.122 0.14 1.2 0.942 1.52 0.14 0.123 0.254 1.15 0.904 1.47 ukb-melanoma-latest-gwas all 441.1 Acute vascular insufficiency of intestine Circulatory System Both 0.987 0.873 1.12 0.836 283 2830 FALSE 0.0777937225609836 -0.0129 0.0625 0.035 0.176 0.843 1.04 0.731 1.47 0.104 0.173 0.55 1.11 0.788 1.56 -0.119 0.181 0.511 0.888 0.62 1.27 ukb-melanoma-latest-gwas all 442 Other aneurysm Circulatory System Both 1.01 0.966 1.06 0.596 1907 19057 FALSE 0.224753740259764 0.0128 0.0241 0.0862 0.0681 0.205 1.09 0.954 1.25 0.0582 0.0685 0.396 1.06 0.927 1.21 0.0446 0.0691 0.518 1.05 0.913 1.2 ukb-melanoma-latest-gwas all 442.1 Aortic aneurysm Circulatory System Both 1.01 0.953 1.06 0.821 1468 14679 FALSE 0.0856568428805593 0.00622 0.0275 0.0803 0.0773 0.299 1.08 0.931 1.26 0.0371 0.0781 0.635 1.04 0.89 1.21 0.0293 0.0787 0.71 1.03 0.882 1.2 ukb-melanoma-latest-gwas all 442.2 Aneurysm of iliac artery Circulatory System Both 1.13 0.925 1.39 0.222 102 1020 FALSE 0.653647025549361 0.126 0.103 -0.266 0.305 0.382 0.766 0.413 1.4 -0.167 0.3 0.578 0.846 0.461 1.54 0.295 0.271 0.275 1.34 0.788 2.32 ukb-melanoma-latest-gwas all 442.3 Aneurysm of artery of lower extremity Circulatory System Both 1.14 0.975 1.34 0.0991 170 1700 FALSE 1.00392634551472 0.134 0.0811 0.398 0.235 0.0898 1.49 0.939 2.39 0.437 0.234 0.0624 1.55 0.978 2.48 0.276 0.243 0.257 1.32 0.815 2.15 ukb-melanoma-latest-gwas all 442.4 Arterial dissection Circulatory System Both 1.04 0.792 1.38 0.754 55 550 FALSE 0.122628654130226 0.0434 0.138 -0.864 0.444 0.052 0.422 0.161 1.01 -0.13 0.361 0.719 0.878 0.424 1.8 -0.12 0.36 0.74 0.887 0.429 1.82 ukb-melanoma-latest-gwas all 442.8 Aneurysm of other specified artery Circulatory System Both 0.937 0.812 1.08 0.371 203 2030 FALSE 0.430626090384954 -0.0653 0.073 0.142 0.205 0.487 1.15 0.77 1.73 0.1 0.206 0.628 1.11 0.735 1.67 -0.0143 0.212 0.946 0.986 0.647 1.5 ukb-melanoma-latest-gwas all 442.11 Abdominal aortic aneurysm Circulatory System Both 1.01 0.947 1.08 0.707 939 9383 FALSE 0.150580586203101 0.0129 0.0344 0.126 0.0971 0.193 1.13 0.938 1.37 0.0733 0.0982 0.455 1.08 0.887 1.31 0.0579 0.0989 0.558 1.06 0.873 1.29 ukb-melanoma-latest-gwas all 443 Peripheral vascular disease Circulatory System Both 1.04 1 1.07 0.0355 3950 39492 TRUE 1.44977164694491 0.0353 0.0168 0.0821 0.0478 0.0863 1.09 0.988 1.19 0.0765 0.048 0.111 1.08 0.983 1.19 0.11 0.0479 0.0214 1.12 1.02 1.23 ukb-melanoma-latest-gwas all 443.1 Raynaud's syndrome Circulatory System Both 1.07 1.01 1.14 0.0237 1145 11450 TRUE 1.6252516539899 0.0704 0.0311 0.121 0.089 0.172 1.13 0.948 1.35 0.0188 0.0911 0.836 1.02 0.852 1.22 0.21 0.0876 0.0163 1.23 1.04 1.47 ukb-melanoma-latest-gwas all 443.7 Peripheral angiopathy in diseases classified elsewhere Circulatory System Both 1.04 0.933 1.15 0.508 390 3900 FALSE 0.294136287716081 0.0352 0.0532 -0.128 0.153 0.401 0.879 0.65 1.19 0.0634 0.147 0.666 1.07 0.798 1.42 -0.0132 0.151 0.93 0.987 0.733 1.33 ukb-melanoma-latest-gwas all 443.9 Peripheral vascular disease, unspecified Circulatory System Both 1.02 0.978 1.06 0.373 2591 25902 FALSE 0.428291168191312 0.0185 0.0207 0.0685 0.0589 0.244 1.07 0.954 1.2 0.0926 0.0587 0.114 1.1 0.978 1.23 0.0552 0.0595 0.353 1.06 0.94 1.19 ukb-melanoma-latest-gwas all 444 Arterial embolism and thrombosis Circulatory System Both 1.04 0.975 1.12 0.218 930 9300 FALSE 0.661543506395395 0.0426 0.0346 0.0761 0.0983 0.439 1.08 0.89 1.31 0.0667 0.0987 0.499 1.07 0.881 1.3 0.11 0.098 0.263 1.12 0.921 1.35 ukb-melanoma-latest-gwas all 444.1 Arterial embolism and thrombosis of lower extremity artery Circulatory System Both 1.05 0.966 1.15 0.234 556 5560 FALSE 0.630784142589857 0.0532 0.0447 0.189 0.126 0.135 1.21 0.943 1.55 0.0056 0.132 0.966 1.01 0.776 1.3 0.207 0.126 0.0999 1.23 0.961 1.58 ukb-melanoma-latest-gwas all 446 Polyarteritis nodosa and allied conditions Circulatory System Both 0.984 0.916 1.06 0.658 829 8290 FALSE 0.181774106386044 -0.0162 0.0366 -0.0834 0.103 0.419 0.92 0.751 1.13 0.00384 0.101 0.97 1 0.823 1.22 -0.0766 0.104 0.461 0.926 0.755 1.14 ukb-melanoma-latest-gwas all 446.4 Wegener's granulomatosis Circulatory System Both 0.969 0.833 1.13 0.681 187 1870 FALSE 0.166852888087215 -0.0315 0.0766 -0.23 0.219 0.293 0.794 0.513 1.22 0.0772 0.206 0.708 1.08 0.719 1.62 -0.103 0.216 0.634 0.902 0.587 1.38 ukb-melanoma-latest-gwas all 446.5 Giant cell arteritis Circulatory System Both 0.992 0.893 1.1 0.876 386 3860 FALSE 0.0574958938319193 -0.00838 0.0536 -0.109 0.15 0.469 0.897 0.666 1.21 -0.08 0.149 0.592 0.923 0.688 1.24 -0.0709 0.15 0.637 0.932 0.693 1.25 ukb-melanoma-latest-gwas all 446.9 Arteritis NOS Circulatory System Both 0.979 0.857 1.12 0.753 240 2400 FALSE 0.123205023799299 -0.0212 0.0675 -0.156 0.189 0.41 0.856 0.587 1.24 -0.138 0.189 0.463 0.871 0.599 1.26 -0.0438 0.186 0.814 0.957 0.663 1.38 ukb-melanoma-latest-gwas all 447 Other disorders of arteries and arterioles Circulatory System Both 1 0.949 1.06 0.894 1336 13360 FALSE 0.0486624812040823 0.00384 0.0288 0.0784 0.0811 0.333 1.08 0.923 1.27 0.0372 0.0819 0.65 1.04 0.884 1.22 0.0267 0.0825 0.747 1.03 0.873 1.21 ukb-melanoma-latest-gwas all 447.1 Stricture of artery Circulatory System Both 1.04 0.968 1.11 0.293 873 8730 FALSE 0.533132379645891 0.0375 0.0357 0.119 0.102 0.243 1.13 0.922 1.37 0.152 0.101 0.133 1.16 0.954 1.42 0.067 0.103 0.516 1.07 0.873 1.31 ukb-melanoma-latest-gwas all 448 Disease of capillaries Circulatory System Both 1.11 0.931 1.32 0.245 142 1420 FALSE 0.610833915635468 0.103 0.0884 0.448 0.261 0.0863 1.57 0.937 2.66 0.519 0.257 0.0435 1.68 1.02 2.83 0.314 0.268 0.241 1.37 0.806 2.36 ukb-melanoma-latest-gwas all 450 Noninfectious disorders of lymphatic channels Circulatory System Both 1.01 0.934 1.09 0.822 705 7050 FALSE 0.0851281824599496 0.00893 0.0396 0.202 0.11 0.0664 1.22 0.986 1.52 -0.149 0.119 0.212 0.862 0.681 1.09 0.169 0.111 0.128 1.18 0.952 1.47 ukb-melanoma-latest-gwas all 451 Phlebitis and thrombophlebitis Circulatory System Both 0.976 0.945 1.01 0.146 4020 40200 FALSE 0.835647144215563 -0.0241 0.0166 0.0712 0.0464 0.125 1.07 0.98 1.18 0.0286 0.0469 0.542 1.03 0.939 1.13 -0.0269 0.0477 0.573 0.973 0.887 1.07 ukb-melanoma-latest-gwas all 451.2 Phlebitis and thrombophlebitis of lower extremities Circulatory System Both 0.973 0.94 1.01 0.107 3707 37070 FALSE 0.97061622231479 -0.0278 0.0173 0.0673 0.0483 0.163 1.07 0.973 1.18 0.0262 0.0488 0.592 1.03 0.933 1.13 -0.0349 0.0497 0.483 0.966 0.876 1.06 ukb-melanoma-latest-gwas all 452 Other venous embolism and thrombosis Circulatory System Both 1.04 0.949 1.13 0.435 566 5660 FALSE 0.361510743045363 0.0346 0.0443 -0.0978 0.128 0.445 0.907 0.705 1.17 -0.042 0.127 0.74 0.959 0.747 1.23 0.17 0.122 0.163 1.19 0.933 1.51 ukb-melanoma-latest-gwas all 454 Varicose veins Circulatory System Both 0.986 0.968 1.01 0.152 12019 120183 FALSE 0.818156412055227 -0.0138 0.00961 0.000775 0.027 0.977 1 0.949 1.06 -0.0149 0.0271 0.583 0.985 0.934 1.04 -0.0247 0.0273 0.366 0.976 0.925 1.03 ukb-melanoma-latest-gwas all 454.1 Varicose veins of lower extremity Circulatory System Both 0.985 0.966 1 0.128 11549 115483 FALSE 0.892790030352132 -0.0149 0.0098 -0.0032 0.0275 0.907 0.997 0.944 1.05 -0.0185 0.0276 0.503 0.982 0.93 1.04 -0.0292 0.0278 0.293 0.971 0.92 1.03 ukb-melanoma-latest-gwas all 454.11 Varicose veins of lower extremity, symptomtic Circulatory System Both 0.975 0.898 1.06 0.541 626 6257 FALSE 0.266802734893431 -0.0256 0.042 -0.0826 0.117 0.479 0.921 0.732 1.16 -0.124 0.118 0.291 0.883 0.7 1.11 -0.0983 0.117 0.403 0.906 0.719 1.14 ukb-melanoma-latest-gwas all 455 Hemorrhoids Circulatory System Both 0.995 0.982 1.01 0.511 23500 234947 FALSE 0.291579099865287 -0.00451 0.00687 0.0369 0.0193 0.0559 1.04 0.999 1.08 0.0112 0.0195 0.563 1.01 0.973 1.05 -0.00338 0.0196 0.863 0.997 0.959 1.04 ukb-melanoma-latest-gwas all 456 Chronic venous insufficiency [CVI] Circulatory System Both 0.931 0.8 1.08 0.347 188 1880 FALSE 0.459670525209126 -0.0719 0.0764 -0.156 0.213 0.463 0.855 0.559 1.3 -0.124 0.212 0.557 0.883 0.579 1.34 -0.0673 0.211 0.75 0.935 0.615 1.42 ukb-melanoma-latest-gwas all 457 Encounter for long-term (current) use of anticoagulants, antithrombotics, aspirin Circulatory System Both 0.855 0.692 1.05 0.138 97 966 FALSE 0.860120913598763 -0.157 0.106 -0.194 0.283 0.494 0.824 0.466 1.44 -0.442 0.301 0.142 0.643 0.348 1.16 -0.215 0.284 0.448 0.806 0.456 1.41 ukb-melanoma-latest-gwas all 458 Hypotension Circulatory System Both 1.01 0.984 1.04 0.442 5801 58010 FALSE 0.354577730650908 0.0106 0.0138 0.0366 0.0392 0.35 1.04 0.961 1.12 0.0503 0.0391 0.198 1.05 0.974 1.14 0.0303 0.0394 0.442 1.03 0.954 1.11 ukb-melanoma-latest-gwas all 458.1 Orthostatic hypotension Circulatory System Both 1.03 0.974 1.09 0.291 1339 13390 FALSE 0.536107011014093 0.0304 0.0288 -0.0499 0.0828 0.547 0.951 0.809 1.12 0.101 0.0802 0.209 1.11 0.945 1.29 0.0245 0.0818 0.765 1.02 0.873 1.2 ukb-melanoma-latest-gwas all 458.2 Iatrogenic hypotension Circulatory System Both 1.21 1.06 1.39 0.0057 234 2340 TRUE 2.24412514432751 0.19 0.0688 0.149 0.207 0.473 1.16 0.771 1.75 0.275 0.201 0.172 1.32 0.887 1.97 0.447 0.197 0.023 1.56 1.06 2.32 ukb-melanoma-latest-gwas all 458.9 Hypotension NOS Circulatory System Both 0.991 0.957 1.03 0.606 3502 35020 FALSE 0.217527375833714 -0.00916 0.0178 0.0124 0.0501 0.804 1.01 0.918 1.12 0.0365 0.0499 0.464 1.04 0.941 1.14 -0.0318 0.0509 0.532 0.969 0.877 1.07 ukb-melanoma-latest-gwas all 459 Other disorders of circulatory system Circulatory System Both 1.01 0.996 1.03 0.146 16386 161616 FALSE 0.835647144215563 0.012 0.00824 0.0314 0.0233 0.178 1.03 0.986 1.08 0.0409 0.0233 0.0792 1.04 0.995 1.09 0.0367 0.0234 0.117 1.04 0.991 1.09 ukb-melanoma-latest-gwas all 459.1 Hemorrhage NOS Circulatory System Both 0.929 0.782 1.1 0.398 142 1420 FALSE 0.400116927926312 -0.0739 0.0874 0.106 0.25 0.671 1.11 0.678 1.83 0.477 0.234 0.0411 1.61 1.02 2.58 -0.5 0.289 0.0833 0.607 0.336 1.07 ukb-melanoma-latest-gwas all 459.9 Circulatory disease NEC Circulatory System Both 1.01 0.997 1.03 0.0982 16173 159853 FALSE 1.00788851221305 0.0137 0.00829 0.0336 0.0235 0.153 1.03 0.988 1.08 0.0384 0.0235 0.102 1.04 0.992 1.09 0.0431 0.0236 0.0675 1.04 0.997 1.09 ukb-melanoma-latest-gwas all 464 Acute sinusitis Respiratory Both 0.934 0.807 1.08 0.361 196 1960 FALSE 0.442492798094342 -0.0679 0.0743 -0.156 0.208 0.454 0.856 0.566 1.29 0.0315 0.199 0.874 1.03 0.697 1.53 -0.312 0.216 0.149 0.732 0.475 1.12 ukb-melanoma-latest-gwas all 465 Acute upper respiratory infections of multiple or unspecified sites Respiratory Both 0.999 0.957 1.04 0.951 2332 23320 FALSE 0.0218194830625861 -0.00135 0.0218 0.0298 0.0617 0.629 1.03 0.913 1.16 0.0678 0.0613 0.269 1.07 0.949 1.21 -0.002 0.0624 0.974 0.998 0.883 1.13 ukb-melanoma-latest-gwas all 465.2 Acute pharyngitis Respiratory Both 1 0.937 1.08 0.893 868 8680 FALSE 0.0491485411114536 0.00479 0.0357 -0.0876 0.102 0.392 0.916 0.749 1.12 0.0466 0.0994 0.639 1.05 0.862 1.27 0.018 0.1 0.858 1.02 0.836 1.24 ukb-melanoma-latest-gwas all 465.4 Acute laryngitis and tracheitis Respiratory Both 1.04 0.882 1.22 0.67 166 1660 FALSE 0.173925197299174 0.0349 0.0818 0.248 0.241 0.304 1.28 0.796 2.08 0.475 0.233 0.0418 1.61 1.02 2.57 0.176 0.247 0.475 1.19 0.732 1.95 ukb-melanoma-latest-gwas all 470 Septal Deviations/Turbinate Hypertrophy Respiratory Both 1.01 0.979 1.04 0.583 4909 49081 FALSE 0.234331445240986 0.00826 0.015 -0.0552 0.0426 0.196 0.946 0.87 1.03 -0.00879 0.0423 0.835 0.991 0.912 1.08 0.000675 0.0423 0.987 1 0.921 1.09 ukb-melanoma-latest-gwas all 471 Nasal polyps Respiratory Both 1 0.969 1.04 0.812 3301 33009 FALSE 0.0904439707588247 0.00437 0.0183 0.0152 0.0519 0.769 1.02 0.917 1.12 0.0521 0.0517 0.313 1.05 0.952 1.17 0.0183 0.0522 0.726 1.02 0.919 1.13 ukb-melanoma-latest-gwas all 472 Chronic pharyngitis and nasopharyngitis Respiratory Both 1.08 1.01 1.15 0.0327 963 9630 TRUE 1.48545224733971 0.0723 0.0339 -0.122 0.0995 0.221 0.885 0.728 1.08 0.095 0.0949 0.317 1.1 0.913 1.33 0.134 0.0943 0.156 1.14 0.95 1.38 ukb-melanoma-latest-gwas all 473 Diseases of the larynx and vocal cords Respiratory Both 1.06 1.02 1.1 0.00628 2623 26230 TRUE 2.2020403562628 0.0564 0.0206 0.0343 0.0594 0.563 1.03 0.921 1.16 0.135 0.0582 0.0204 1.14 1.02 1.28 0.11 0.0588 0.0624 1.12 0.994 1.25 ukb-melanoma-latest-gwas all 473.1 Chronic laryngitis Respiratory Both 0.979 0.8 1.2 0.837 104 1040 FALSE 0.07727454200674 -0.021 0.102 -0.264 0.284 0.352 0.768 0.434 1.34 -0.155 0.28 0.58 0.856 0.488 1.49 -0.139 0.281 0.622 0.871 0.495 1.52 ukb-melanoma-latest-gwas all 473.3 Paralysis/spasm of vocal cords or larynx Respiratory Both 1.06 0.933 1.2 0.371 265 2650 FALSE 0.430626090384954 0.0576 0.0644 0.166 0.187 0.376 1.18 0.816 1.71 0.183 0.187 0.329 1.2 0.83 1.74 0.276 0.186 0.139 1.32 0.914 1.91 ukb-melanoma-latest-gwas all 473.4 Voice disturbance Respiratory Both 1.12 1.06 1.2 0.000258 1083 10830 TRUE 3.58838029403677 0.118 0.0322 0.188 0.0943 0.0458 1.21 1 1.45 0.259 0.0933 0.00558 1.3 1.08 1.56 0.302 0.0929 0.00114 1.35 1.13 1.62 ukb-melanoma-latest-gwas all 474 Acute and chronic tonsillitis Respiratory Both 0.973 0.93 1.02 0.253 2008 20072 FALSE 0.596879478824182 -0.0269 0.0235 -0.00322 0.0649 0.96 0.997 0.878 1.13 -0.147 0.0674 0.0289 0.863 0.756 0.985 -0.0345 0.0658 0.6 0.966 0.849 1.1 ukb-melanoma-latest-gwas all 474.1 Acute tonsillitis Respiratory Both 0.934 0.859 1.01 0.107 613 6130 FALSE 0.97061622231479 -0.0685 0.0424 -0.0238 0.115 0.837 0.976 0.778 1.22 -0.264 0.123 0.0313 0.768 0.602 0.977 -0.0843 0.118 0.474 0.919 0.729 1.16 ukb-melanoma-latest-gwas all 474.2 Chronic tonsillitis and adenoiditis Respiratory Both 0.969 0.911 1.03 0.314 1124 11232 FALSE 0.503070351926785 -0.0315 0.0313 -0.0265 0.087 0.76 0.974 0.821 1.16 -0.126 0.0893 0.157 0.881 0.739 1.05 -0.0451 0.0878 0.607 0.956 0.804 1.14 ukb-melanoma-latest-gwas all 475 Chronic sinusitis Respiratory Both 1.01 0.971 1.05 0.578 2596 25951 FALSE 0.238072161579471 0.0115 0.0207 0.0591 0.0589 0.316 1.06 0.945 1.19 0.0951 0.0584 0.104 1.1 0.981 1.23 0.0481 0.0593 0.417 1.05 0.934 1.18 ukb-melanoma-latest-gwas all 476 Allergic rhinitis Respiratory Both 1.01 0.944 1.07 0.853 1059 10590 FALSE 0.069050968832477 0.00598 0.0323 0.0416 0.0921 0.651 1.04 0.87 1.25 0.14 0.0904 0.121 1.15 0.964 1.37 -0.0024 0.0934 0.979 0.998 0.83 1.2 ukb-melanoma-latest-gwas all 477 Epistaxis or throat hemorrhage Respiratory Both 0.994 0.953 1.04 0.778 2452 24509 FALSE 0.109020403010311 -0.00599 0.0213 -0.0477 0.0597 0.424 0.953 0.848 1.07 -0.0867 0.0603 0.151 0.917 0.815 1.03 -0.00781 0.0594 0.895 0.992 0.883 1.11 ukb-melanoma-latest-gwas all 478 Throat pain Respiratory Both 1.11 0.994 1.23 0.063 379 3790 FALSE 1.20065945054642 0.1 0.054 -0.0185 0.159 0.907 0.982 0.717 1.34 0.257 0.15 0.0864 1.29 0.964 1.74 0.125 0.154 0.419 1.13 0.836 1.54 ukb-melanoma-latest-gwas all 479 Other upper respiratory disease Respiratory Both 1.06 1.02 1.09 0.000984 4089 40884 TRUE 3.00700490156866 0.0544 0.0165 -0.0339 0.0477 0.477 0.967 0.88 1.06 0.066 0.0467 0.157 1.07 0.975 1.17 0.119 0.0463 0.0102 1.13 1.03 1.23 ukb-melanoma-latest-gwas all 480 Pneumonia Respiratory Both 0.998 0.978 1.02 0.879 10456 104475 FALSE 0.0560111249262281 -0.00157 0.0103 -0.019 0.029 0.513 0.981 0.927 1.04 -0.0284 0.0291 0.329 0.972 0.918 1.03 -0.0201 0.0291 0.491 0.98 0.926 1.04 ukb-melanoma-latest-gwas all 480.1 Bacterial pneumonia Respiratory Both 1 0.977 1.03 0.868 6691 66910 FALSE 0.0614802748235081 0.00213 0.0129 0.0117 0.0362 0.746 1.01 0.943 1.09 -0.0196 0.0365 0.591 0.981 0.913 1.05 -0.0111 0.0365 0.76 0.989 0.921 1.06 ukb-melanoma-latest-gwas all 480.2 Viral pneumonia Respiratory Both 1.24 0.974 1.6 0.0781 73 730 FALSE 1.1073489661227 0.218 0.124 0.422 0.394 0.284 1.53 0.694 3.49 0.83 0.374 0.0266 2.29 1.11 5.07 0.817 0.377 0.0302 2.26 1.08 5.04 ukb-melanoma-latest-gwas all 480.3 Pneumonia due to fungus (mycoses) Respiratory Both 1.3 1.06 1.61 0.0116 101 1010 TRUE 1.93554201077308 0.265 0.105 -0.0459 0.314 0.884 0.955 0.507 1.8 0.182 0.303 0.549 1.2 0.656 2.21 0.508 0.285 0.0749 1.66 0.951 2.97 ukb-melanoma-latest-gwas all 480.5 Bronchopneumonia and lung abscess Respiratory Both 0.943 0.876 1.01 0.113 802 8020 FALSE 0.94692155651658 -0.0589 0.0372 -0.0344 0.104 0.741 0.966 0.788 1.18 0.0293 0.102 0.775 1.03 0.842 1.26 -0.154 0.108 0.153 0.857 0.694 1.06 ukb-melanoma-latest-gwas all 480.11 Pneumococcal pneumonia Respiratory Both 1.01 0.979 1.03 0.658 5936 59360 FALSE 0.181774106386044 0.00604 0.0137 0.0315 0.0383 0.411 1.03 0.957 1.11 -0.031 0.0389 0.427 0.97 0.898 1.05 0.00974 0.0387 0.801 1.01 0.936 1.09 ukb-melanoma-latest-gwas all 480.12 Pseudomonal pneumonia Respiratory Both 1 0.807 1.24 0.994 93 930 FALSE 0.00261361560268669 0.000753 0.108 -0.129 0.308 0.675 0.879 0.473 1.63 0.13 0.297 0.662 1.14 0.631 2.07 -0.0164 0.308 0.958 0.984 0.53 1.82 ukb-melanoma-latest-gwas all 481 Influenza Respiratory Both 0.936 0.835 1.05 0.251 331 3310 FALSE 0.600326278518962 -0.0665 0.0579 -0.024 0.162 0.883 0.976 0.709 1.34 0.165 0.157 0.293 1.18 0.867 1.61 -0.208 0.171 0.223 0.812 0.579 1.14 ukb-melanoma-latest-gwas all 483 Acute bronchitis and bronchiolitis Respiratory Both 1.1 0.948 1.28 0.207 194 1940 FALSE 0.684029654543082 0.0951 0.0754 0.0973 0.221 0.66 1.1 0.711 1.71 0.262 0.213 0.219 1.3 0.854 1.99 0.225 0.216 0.299 1.25 0.818 1.93 ukb-melanoma-latest-gwas all 495 Asthma Respiratory Both 1 0.987 1.01 0.99 25799 251156 FALSE 0.00436480540245009 8.22e-05 0.00657 -0.0135 0.0186 0.469 0.987 0.951 1.02 0.00563 0.0185 0.761 1.01 0.97 1.04 0.00225 0.0186 0.904 1 0.966 1.04 ukb-melanoma-latest-gwas all 495.2 Asthma with exacerbation Respiratory Both 0.959 0.843 1.09 0.526 252 2520 FALSE 0.279014255846261 -0.0417 0.0658 -0.225 0.183 0.221 0.799 0.555 1.15 -0.0745 0.178 0.675 0.928 0.653 1.32 -0.313 0.188 0.0965 0.731 0.503 1.06 ukb-melanoma-latest-gwas all 496 Chronic airway obstruction Respiratory Both 1.01 0.991 1.03 0.293 10487 102024 FALSE 0.533132379645891 0.0108 0.0103 0.0393 0.0292 0.178 1.04 0.982 1.1 0.0328 0.0293 0.263 1.03 0.976 1.09 0.0464 0.0293 0.114 1.05 0.989 1.11 ukb-melanoma-latest-gwas all 496.1 Emphysema Respiratory Both 0.969 0.923 1.02 0.218 1754 17540 FALSE 0.661543506395395 -0.031 0.0252 0.0404 0.0696 0.562 1.04 0.908 1.19 -0.099 0.072 0.169 0.906 0.786 1.04 -0.0419 0.0712 0.556 0.959 0.834 1.1 ukb-melanoma-latest-gwas all 496.2 Chronic bronchitis Respiratory Both 1.01 0.97 1.05 0.703 2965 29592 FALSE 0.153044674980176 0.00739 0.0194 0.0455 0.0547 0.405 1.05 0.94 1.16 0.0315 0.055 0.566 1.03 0.927 1.15 0.0344 0.0551 0.532 1.04 0.929 1.15 ukb-melanoma-latest-gwas all 496.3 Bronchiectasis Respiratory Both 1.04 0.993 1.09 0.0987 1893 18930 FALSE 1.00568284733036 0.04 0.0242 0.0636 0.0691 0.358 1.07 0.931 1.22 0.0647 0.0692 0.35 1.07 0.931 1.22 0.112 0.0687 0.102 1.12 0.978 1.28 ukb-melanoma-latest-gwas all 496.21 Obstructive chronic bronchitis Respiratory Both 1.01 0.974 1.05 0.501 2722 27164 FALSE 0.300162274132754 0.0136 0.0202 0.0691 0.0573 0.227 1.07 0.958 1.2 0.0674 0.0574 0.241 1.07 0.956 1.2 0.05 0.0578 0.387 1.05 0.939 1.18 ukb-melanoma-latest-gwas all 497 Bronchitis Respiratory Both 1.01 0.929 1.09 0.838 634 6332 FALSE 0.0767559813697235 0.00854 0.0418 -0.0738 0.118 0.532 0.929 0.736 1.17 -0.095 0.119 0.424 0.909 0.72 1.15 0.0465 0.115 0.687 1.05 0.835 1.31 ukb-melanoma-latest-gwas all 500 Lung disease due to external agents Respiratory Both 1.14 1.03 1.26 0.0114 413 4113 TRUE 1.94309514866353 0.131 0.0517 0.33 0.149 0.0267 1.39 1.04 1.87 0.0187 0.16 0.907 1.02 0.744 1.4 0.397 0.147 0.00705 1.49 1.12 1.99 ukb-melanoma-latest-gwas all 500.1 Extrinsic allergic alveolitis Respiratory Both 1.06 0.841 1.34 0.61 79 790 FALSE 0.214670164989233 0.0593 0.116 0.231 0.34 0.496 1.26 0.64 2.51 0.106 0.346 0.758 1.11 0.555 2.24 0.339 0.327 0.3 1.4 0.735 2.73 ukb-melanoma-latest-gwas all 500.2 Pneumoconiosis Respiratory Both 1.18 1.03 1.35 0.0153 244 2423 TRUE 1.8153085691824 0.164 0.0674 0.414 0.192 0.031 1.51 1.04 2.22 -0.0453 0.211 0.83 0.956 0.628 1.45 0.439 0.193 0.0225 1.55 1.06 2.28 ukb-melanoma-latest-gwas all 501 Pneumonitis due to inhalation of food or vomitus Respiratory Both 1.04 0.958 1.13 0.357 657 6570 FALSE 0.447331783887807 0.0379 0.0411 0.134 0.117 0.25 1.14 0.909 1.44 0.0363 0.12 0.762 1.04 0.82 1.31 0.186 0.117 0.112 1.2 0.958 1.52 ukb-melanoma-latest-gwas all 502 Postinflammatory pulmonary fibrosis Respiratory Both 0.982 0.917 1.05 0.6 924 9240 FALSE 0.221848749616356 -0.0182 0.0346 -0.161 0.0988 0.104 0.852 0.701 1.03 0.000673 0.0954 0.994 1 0.83 1.21 -0.067 0.0971 0.49 0.935 0.773 1.13 ukb-melanoma-latest-gwas all 503 Pulmonary congestion and hypostasis Respiratory Both 1.03 0.937 1.12 0.582 515 5150 FALSE 0.235077015350112 0.0255 0.0463 0.0081 0.134 0.952 1.01 0.775 1.31 0.136 0.13 0.296 1.15 0.887 1.48 0.114 0.131 0.385 1.12 0.866 1.45 ukb-melanoma-latest-gwas all 504 Other alveolar and parietoalveolar pneumonopathy Respiratory Both 0.937 0.836 1.05 0.258 330 3300 FALSE 0.58838029403677 -0.0655 0.0579 -0.228 0.163 0.161 0.796 0.576 1.1 -0.115 0.157 0.467 0.892 0.653 1.22 -0.174 0.161 0.278 0.84 0.611 1.15 ukb-melanoma-latest-gwas all 505 Other pulmonary inflamation or edema Respiratory Both 0.851 0.66 1.1 0.209 61 610 FALSE 0.679853713888946 -0.162 0.129 0.348 0.353 0.324 1.42 0.705 2.92 0.0335 0.378 0.929 1.03 0.481 2.23 -0.0575 0.393 0.884 0.944 0.422 2.09 ukb-melanoma-latest-gwas all 506 Empyema and pneumothorax Respiratory Both 1 0.943 1.06 0.969 1181 11803 FALSE 0.0136762229492347 0.00119 0.0307 -0.0497 0.0861 0.564 0.952 0.803 1.13 -0.094 0.087 0.28 0.91 0.767 1.08 0.0181 0.0855 0.833 1.02 0.861 1.2 ukb-melanoma-latest-gwas all 507 Pleurisy; pleural effusion Respiratory Both 0.997 0.972 1.02 0.819 6440 64382 FALSE 0.0867160982395816 -0.003 0.0131 -0.0234 0.037 0.526 0.977 0.909 1.05 -0.00927 0.0369 0.801 0.991 0.922 1.07 -0.0307 0.0372 0.409 0.97 0.902 1.04 ukb-melanoma-latest-gwas all 508 Pulmonary collapse; interstitial and compensatory emphysema Respiratory Both 0.985 0.941 1.03 0.525 2002 20020 FALSE 0.279840696594043 -0.0149 0.0235 -0.103 0.0664 0.121 0.902 0.792 1.03 -0.00368 0.065 0.955 0.996 0.877 1.13 -0.104 0.0667 0.121 0.902 0.791 1.03 ukb-melanoma-latest-gwas all 509 Respiratory failure, insufficiency, arrest Respiratory Both 1.01 0.967 1.05 0.765 2648 26474 FALSE 0.116338564846382 0.00612 0.0205 -0.0345 0.0577 0.55 0.966 0.863 1.08 0.00327 0.0573 0.954 1 0.897 1.12 -0.0378 0.0581 0.515 0.963 0.859 1.08 ukb-melanoma-latest-gwas all 509.1 Respiratory failure Respiratory Both 1.01 0.97 1.06 0.528 2079 20784 FALSE 0.277366077466188 0.0146 0.0231 -0.0208 0.0654 0.751 0.979 0.862 1.11 0.00879 0.0649 0.892 1.01 0.888 1.15 0.00199 0.0653 0.976 1 0.881 1.14 ukb-melanoma-latest-gwas all 509.2 Respiratory insufficiency Respiratory Both 1.02 0.97 1.07 0.463 1819 18184 FALSE 0.334419008982047 0.0181 0.0247 -0.0463 0.0698 0.507 0.955 0.832 1.09 -0.0326 0.0696 0.639 0.968 0.844 1.11 0.00573 0.0693 0.934 1.01 0.878 1.15 ukb-melanoma-latest-gwas all 509.5 Respiratory arrest Respiratory Both 0.968 0.816 1.15 0.712 144 1440 FALSE 0.147520006363144 -0.0321 0.0867 0.0897 0.251 0.721 1.09 0.664 1.81 0.29 0.242 0.231 1.34 0.831 2.17 -0.0211 0.258 0.935 0.979 0.585 1.64 ukb-melanoma-latest-gwas all 509.8 Dependence on respirator [Ventilator] or supplemental oxygen Respiratory Both 1.01 0.908 1.12 0.88 389 3890 FALSE 0.0555173278498314 0.00805 0.0533 0.0384 0.148 0.796 1.04 0.776 1.39 0.0359 0.149 0.809 1.04 0.773 1.39 -0.101 0.154 0.511 0.904 0.667 1.22 ukb-melanoma-latest-gwas all 510 Other diseases of lung Respiratory Both 1.09 1.02 1.18 0.0187 757 7570 TRUE 1.7281583934635 0.0902 0.0383 0.193 0.114 0.0891 1.21 0.971 1.52 0.357 0.11 0.00124 1.43 1.15 1.78 0.274 0.113 0.0151 1.31 1.05 1.64 ukb-melanoma-latest-gwas all 512 Other symptoms of respiratory system Respiratory Both 1.02 1 1.05 0.0275 9079 90783 TRUE 1.56066730616974 0.0244 0.0111 0.0168 0.0314 0.592 1.02 0.956 1.08 0.0467 0.0313 0.135 1.05 0.986 1.11 0.0393 0.0314 0.211 1.04 0.978 1.11 ukb-melanoma-latest-gwas all 512.1 Wheezing Respiratory Both 1.04 0.907 1.2 0.561 220 2200 FALSE 0.251037138743839 0.0412 0.0708 0.239 0.204 0.242 1.27 0.85 1.91 0.109 0.209 0.601 1.12 0.738 1.69 0.312 0.201 0.122 1.37 0.92 2.04 ukb-melanoma-latest-gwas all 512.2 Painful respiration Respiratory Both 1.05 0.91 1.21 0.506 208 2080 FALSE 0.295849483160201 0.0484 0.0727 0.00642 0.213 0.976 1.01 0.66 1.54 0.248 0.202 0.22 1.28 0.861 1.92 0.117 0.208 0.575 1.12 0.746 1.7 ukb-melanoma-latest-gwas all 512.7 Shortness of breath Respiratory Both 1.03 1 1.06 0.049 5855 58547 TRUE 1.30980391997149 0.0271 0.0138 0.00172 0.0392 0.965 1 0.928 1.08 0.0558 0.0388 0.15 1.06 0.98 1.14 0.029 0.0392 0.459 1.03 0.953 1.11 ukb-melanoma-latest-gwas all 512.8 Cough Respiratory Both 1.03 0.99 1.07 0.149 2864 28636 FALSE 0.826813731587726 0.0284 0.0197 0.0419 0.056 0.454 1.04 0.934 1.16 0.0557 0.0559 0.319 1.06 0.948 1.18 0.0567 0.056 0.311 1.06 0.948 1.18 ukb-melanoma-latest-gwas all 512.9 Other dyspnea Respiratory Both 1.02 0.95 1.09 0.628 907 9070 FALSE 0.202040356262804 0.017 0.035 0.0119 0.0989 0.904 1.01 0.833 1.23 -0.0528 0.1 0.599 0.949 0.779 1.16 0.0919 0.0977 0.347 1.1 0.905 1.33 ukb-melanoma-latest-gwas all 513 Respiratory abnormalities Respiratory Both 1.08 0.994 1.17 0.0689 614 6136 FALSE 1.16178077809237 0.0774 0.0425 0.00719 0.124 0.954 1.01 0.789 1.29 0.146 0.12 0.224 1.16 0.914 1.47 0.211 0.12 0.0776 1.24 0.977 1.56 ukb-melanoma-latest-gwas all 513.3 Hypoventilation Respiratory Both 1.14 0.909 1.44 0.248 83 830 FALSE 0.605548319173784 0.134 0.116 0.0272 0.321 0.932 1.03 0.54 1.96 -0.0814 0.33 0.805 0.922 0.473 1.79 0.109 0.319 0.732 1.12 0.591 2.12 ukb-melanoma-latest-gwas all 513.4 Hyperventilation Respiratory Both 0.967 0.855 1.09 0.592 278 2780 FALSE 0.22767829327708 -0.0336 0.0628 -0.049 0.181 0.786 0.952 0.666 1.36 0.157 0.172 0.362 1.17 0.834 1.65 -0.00903 0.18 0.96 0.991 0.694 1.42 ukb-melanoma-latest-gwas all 513.8 Disorders of diaphragm Respiratory Both 1.05 0.893 1.25 0.529 154 1540 FALSE 0.276544327964814 0.0532 0.0845 0.175 0.24 0.467 1.19 0.74 1.92 0.0756 0.245 0.758 1.08 0.663 1.76 0.208 0.239 0.385 1.23 0.768 1.98 ukb-melanoma-latest-gwas all 514 Abnormal findings examination of lungs Respiratory Both 1.02 0.975 1.06 0.433 2473 24719 FALSE 0.363512103646635 0.0166 0.0212 -0.0174 0.0606 0.774 0.983 0.873 1.11 0.059 0.0597 0.323 1.06 0.944 1.19 0.0509 0.06 0.396 1.05 0.935 1.18 ukb-melanoma-latest-gwas all 516 Abnormal sputum Respiratory Both 1.01 0.962 1.05 0.792 2172 21713 FALSE 0.101274818410506 0.00597 0.0226 -0.0232 0.0638 0.716 0.977 0.862 1.11 -0.0276 0.0639 0.665 0.973 0.858 1.1 0.00546 0.0638 0.932 1.01 0.887 1.14 ukb-melanoma-latest-gwas all 516.1 Hemoptysis Respiratory Both 1.01 0.965 1.06 0.666 2079 20781 FALSE 0.176525770829699 0.00997 0.0231 -0.0212 0.0654 0.746 0.979 0.861 1.11 -0.0255 0.0654 0.697 0.975 0.857 1.11 0.0311 0.065 0.633 1.03 0.908 1.17 ukb-melanoma-latest-gwas all 519 Other diseases of respiratory system, not elsewhere classified Respiratory Both 1.01 0.988 1.03 0.425 9497 94944 FALSE 0.371611069949688 0.00864 0.0108 -0.00526 0.0307 0.864 0.995 0.937 1.06 0.0304 0.0305 0.319 1.03 0.971 1.09 0.0198 0.0307 0.518 1.02 0.961 1.08 ukb-melanoma-latest-gwas all 519.2 Respiratory complications Respiratory Both 0.972 0.868 1.09 0.627 328 3280 FALSE 0.202732459169284 -0.0282 0.0579 -0.058 0.159 0.715 0.944 0.689 1.29 -0.227 0.165 0.169 0.797 0.574 1.1 -0.0531 0.161 0.741 0.948 0.691 1.3 ukb-melanoma-latest-gwas all 519.8 Other diseases of respiratory system, NEC Respiratory Both 1.01 0.986 1.03 0.462 8881 88784 FALSE 0.335358024443874 0.00822 0.0112 0.00664 0.0317 0.834 1.01 0.946 1.07 0.0429 0.0315 0.173 1.04 0.981 1.11 0.0144 0.0318 0.651 1.01 0.953 1.08 ukb-melanoma-latest-gwas all 519.9 Symptoms involving respiratory system and other chest symptoms Respiratory Both 1.03 0.915 1.16 0.627 305 3050 FALSE 0.202732459169284 0.0292 0.0601 -0.173 0.174 0.322 0.842 0.596 1.19 -0.0242 0.168 0.885 0.976 0.701 1.36 0.0891 0.165 0.59 1.09 0.79 1.52 ukb-melanoma-latest-gwas all 520 Disorders of tooth development Digestive Both 1.04 0.997 1.08 0.0698 2446 24460 FALSE 1.15614457737684 0.0387 0.0213 0.0096 0.0615 0.876 1.01 0.895 1.14 0.105 0.0602 0.0809 1.11 0.987 1.25 0.0967 0.0605 0.11 1.1 0.978 1.24 ukb-melanoma-latest-gwas all 520.1 Hereditary disturbances in tooth structure Digestive Both 1.03 0.775 1.37 0.841 53 530 FALSE 0.0752040042020878 0.0285 0.142 -0.304 0.399 0.446 0.738 0.323 1.64 -0.571 0.431 0.185 0.565 0.226 1.32 0.0416 0.367 0.91 1.04 0.502 2.18 ukb-melanoma-latest-gwas all 520.2 Disturbances in tooth eruption Digestive Both 1.04 1 1.09 0.0515 2361 23610 FALSE 1.28819277095881 0.0423 0.0217 0.0291 0.0626 0.642 1.03 0.911 1.16 0.114 0.0615 0.063 1.12 0.994 1.26 0.115 0.0617 0.0633 1.12 0.994 1.27 ukb-melanoma-latest-gwas all 521 Diseases of hard tissues of teeth Digestive Both 1.01 0.971 1.05 0.685 3087 30870 FALSE 0.164309428507574 0.00769 0.019 0.0219 0.053 0.68 1.02 0.921 1.13 -0.0539 0.054 0.318 0.948 0.852 1.05 0.00664 0.0535 0.901 1.01 0.906 1.12 ukb-melanoma-latest-gwas all 521.1 Dental caries Digestive Both 1.01 0.97 1.05 0.718 3047 30470 FALSE 0.1438755557577 0.00688 0.0191 0.0208 0.0533 0.696 1.02 0.92 1.13 -0.0575 0.0544 0.291 0.944 0.849 1.05 0.00698 0.0538 0.897 1.01 0.906 1.12 ukb-melanoma-latest-gwas all 522 Diseases of pulp and periapical tissues Digestive Both 0.996 0.948 1.05 0.862 1792 17917 FALSE 0.0644927341752872 -0.00431 0.0249 0.0585 0.0699 0.403 1.06 0.924 1.22 0.0166 0.0707 0.814 1.02 0.885 1.17 0.00682 0.071 0.923 1.01 0.876 1.16 ukb-melanoma-latest-gwas all 522.5 Periapical abscess Digestive Both 0.956 0.9 1.02 0.14 1175 11750 FALSE 0.853871964321762 -0.0453 0.0307 0.0198 0.0855 0.817 1.02 0.862 1.21 0.0243 0.0857 0.777 1.02 0.866 1.21 -0.11 0.0885 0.212 0.895 0.752 1.07 ukb-melanoma-latest-gwas all 523 Gingival and periodontal diseases Digestive Both 0.964 0.918 1.01 0.147 1741 17410 FALSE 0.832682665251824 -0.0366 0.0252 0.0328 0.0701 0.64 1.03 0.901 1.19 -0.017 0.0709 0.81 0.983 0.855 1.13 -0.0796 0.0722 0.27 0.923 0.801 1.06 ukb-melanoma-latest-gwas all 523.1 Gingivitis Digestive Both 1.01 0.835 1.23 0.901 114 1140 FALSE 0.045275209020937 0.0121 0.0976 -0.0526 0.262 0.841 0.949 0.563 1.6 -0.665 0.307 0.0305 0.514 0.272 0.937 0.0895 0.256 0.726 1.09 0.659 1.82 ukb-melanoma-latest-gwas all 523.3 Periodontitis (acute or chronic) Digestive Both 0.973 0.917 1.03 0.357 1222 12220 FALSE 0.447331783887807 -0.0277 0.0301 0.0428 0.0844 0.612 1.04 0.884 1.23 0.029 0.0846 0.732 1.03 0.872 1.22 -0.0326 0.0862 0.706 0.968 0.817 1.15 ukb-melanoma-latest-gwas all 523.31 Acute periodontitis Digestive Both 1.02 0.942 1.11 0.618 668 6680 FALSE 0.209011524911184 0.0203 0.0406 0.111 0.117 0.342 1.12 0.888 1.41 0.203 0.115 0.0777 1.22 0.978 1.54 0.0942 0.118 0.424 1.1 0.872 1.39 ukb-melanoma-latest-gwas all 523.32 Chronic periodontitis Digestive Both 0.923 0.846 1.01 0.0693 561 5610 FALSE 1.15926676538819 -0.0803 0.0442 -0.107 0.122 0.378 0.898 0.707 1.14 -0.199 0.124 0.109 0.819 0.641 1.05 -0.163 0.124 0.189 0.85 0.665 1.08 ukb-melanoma-latest-gwas all 524 Dentofacial anomalies, including malocclusion Digestive Both 1.12 1.01 1.26 0.0385 345 3450 TRUE 1.4145392704915 0.117 0.0566 -0.226 0.173 0.192 0.798 0.565 1.12 0.271 0.156 0.0834 1.31 0.965 1.79 0.207 0.159 0.193 1.23 0.9 1.68 ukb-melanoma-latest-gwas all 524.3 Anomalies of tooth position/malocclusion Digestive Both 1.14 1.01 1.28 0.0343 305 3050 TRUE 1.46470587995723 0.127 0.0601 -0.221 0.185 0.233 0.802 0.555 1.15 0.311 0.165 0.0595 1.37 0.988 1.9 0.194 0.17 0.251 1.21 0.871 1.7 ukb-melanoma-latest-gwas all 525 Other diseases of the teeth and supporting structures Digestive Both 1.01 0.971 1.05 0.592 2685 26850 FALSE 0.22767829327708 0.0109 0.0203 0.0988 0.0573 0.0844 1.1 0.987 1.24 0.0445 0.058 0.443 1.05 0.933 1.17 0.0326 0.0584 0.577 1.03 0.921 1.16 ukb-melanoma-latest-gwas all 525.2 Atrophy of edentulous alveolar ridge Digestive Both 0.853 0.672 1.09 0.187 72 720 FALSE 0.728158393463501 -0.159 0.121 -0.309 0.328 0.347 0.735 0.377 1.41 -0.241 0.325 0.457 0.786 0.407 1.49 -0.465 0.343 0.175 0.628 0.31 1.23 ukb-melanoma-latest-gwas all 526 Diseases of the jaws Digestive Both 1.01 0.943 1.08 0.825 959 9590 FALSE 0.0835460514500749 0.00754 0.034 -0.0113 0.0944 0.905 0.989 0.821 1.19 -0.169 0.0979 0.0838 0.844 0.696 1.02 0.00196 0.0944 0.983 1 0.832 1.21 ukb-melanoma-latest-gwas all 526.1 Cysts of the jaws Digestive Both 0.996 0.889 1.12 0.941 329 3290 FALSE 0.0264103765727431 -0.00426 0.0579 0.00248 0.16 0.988 1 0.731 1.37 -0.215 0.169 0.205 0.807 0.576 1.13 0.0294 0.159 0.853 1.03 0.753 1.41 ukb-melanoma-latest-gwas all 526.3 Anomalies of jaw size/symmetry Digestive Both 0.881 0.678 1.15 0.338 61 610 FALSE 0.471083299722345 -0.127 0.132 0.156 0.351 0.657 1.17 0.582 2.37 -0.246 0.378 0.514 0.782 0.361 1.67 -0.275 0.378 0.467 0.759 0.351 1.62 ukb-melanoma-latest-gwas all 526.4 Temporomandibular joint disorders Digestive Both 1.09 0.952 1.24 0.212 240 2400 FALSE 0.673664139071249 0.0843 0.0676 -0.153 0.195 0.432 0.858 0.582 1.26 -0.076 0.191 0.691 0.927 0.635 1.35 0.133 0.184 0.468 1.14 0.796 1.64 ukb-melanoma-latest-gwas all 526.5 Inflammatory conditions of jaw Digestive Both 0.955 0.785 1.16 0.64 110 1100 FALSE 0.193820026016113 -0.0464 0.0991 -0.638 0.288 0.0266 0.528 0.293 0.926 -0.315 0.264 0.233 0.73 0.429 1.23 -0.351 0.267 0.188 0.704 0.411 1.19 ukb-melanoma-latest-gwas all 526.9 Jaw disease NOS Digestive Both 0.997 0.871 1.14 0.965 234 2340 FALSE 0.0154726866562074 -0.00305 0.0688 0.253 0.19 0.184 1.29 0.886 1.88 -0.0832 0.204 0.684 0.92 0.613 1.38 0.129 0.197 0.513 1.14 0.771 1.68 ukb-melanoma-latest-gwas all 526.41 Temporomandibular joint disorder, unspecified Digestive Both 1.09 0.954 1.25 0.199 233 2330 FALSE 0.701146923590293 0.088 0.0685 -0.153 0.199 0.441 0.858 0.578 1.27 -0.074 0.194 0.703 0.929 0.632 1.36 0.149 0.186 0.422 1.16 0.805 1.68 ukb-melanoma-latest-gwas all 527 Diseases of the salivary glands Digestive Both 1.01 0.936 1.09 0.764 710 7100 FALSE 0.11690664142431 0.0119 0.0395 0.0602 0.112 0.591 1.06 0.852 1.32 0.0295 0.113 0.794 1.03 0.825 1.29 0.0858 0.112 0.444 1.09 0.874 1.36 ukb-melanoma-latest-gwas all 527.1 Hypertrophy of salivary gland Digestive Both 0.891 0.711 1.12 0.311 84 840 FALSE 0.507239610973163 -0.115 0.114 0.0609 0.315 0.847 1.06 0.566 2 0.35 0.303 0.248 1.42 0.781 2.62 -0.32 0.353 0.364 0.726 0.351 1.47 ukb-melanoma-latest-gwas all 527.2 Sialoadenitis Digestive Both 1 0.9 1.12 0.966 366 3660 FALSE 0.0150228735845067 0.00237 0.0549 0.0339 0.154 0.826 1.03 0.764 1.4 -0.0719 0.158 0.649 0.931 0.681 1.27 0.0532 0.154 0.729 1.05 0.78 1.43 ukb-melanoma-latest-gwas all 527.7 Disturbance of salivary secretion Digestive Both 1.01 0.781 1.31 0.925 63 630 FALSE 0.0338582672609674 0.0123 0.131 0.155 0.376 0.681 1.17 0.545 2.52 0.379 0.352 0.283 1.46 0.729 3 -0.179 0.399 0.654 0.836 0.372 1.86 ukb-melanoma-latest-gwas all 527.8 Other specified diseases of the salivary glands Digestive Both 1.14 0.947 1.39 0.161 120 1200 FALSE 0.79317412396815 0.135 0.0963 0.104 0.278 0.708 1.11 0.639 1.94 0.0735 0.278 0.791 1.08 0.619 1.88 0.295 0.268 0.271 1.34 0.792 2.31 ukb-melanoma-latest-gwas all 528 Diseases of the oral soft tissues, excluding lesions specific for gingiva and tongue Digestive Both 1.03 0.993 1.06 0.123 3927 39270 FALSE 0.910094888560602 0.026 0.0168 -0.0164 0.0479 0.731 0.984 0.896 1.08 -0.000825 0.0478 0.986 0.999 0.91 1.1 0.0757 0.0471 0.108 1.08 0.984 1.18 ukb-melanoma-latest-gwas all 528.1 Stomatitis and mucositis Digestive Both 1.06 0.967 1.17 0.202 469 4690 FALSE 0.694648630553376 0.062 0.0486 -0.0902 0.14 0.521 0.914 0.693 1.2 0.0313 0.137 0.82 1.03 0.787 1.35 0.126 0.135 0.352 1.13 0.87 1.48 ukb-melanoma-latest-gwas all 528.3 Cellulitis and abscess of oral soft tissues Digestive Both 1 0.858 1.17 0.99 181 1810 FALSE 0.00436480540245009 0.000994 0.0782 -0.141 0.215 0.511 0.868 0.566 1.33 -0.391 0.23 0.0891 0.677 0.426 1.06 0.0229 0.208 0.913 1.02 0.678 1.55 ukb-melanoma-latest-gwas all 528.4 Cysts of oral soft tissues Digestive Both 0.93 0.774 1.12 0.439 125 1250 FALSE 0.357535479757879 -0.072 0.0931 -0.168 0.254 0.509 0.845 0.508 1.4 -0.657 0.286 0.0219 0.519 0.288 0.907 0.0132 0.243 0.957 1.01 0.626 1.64 ukb-melanoma-latest-gwas all 528.5 Diseases of lips Digestive Both 1.09 1.01 1.18 0.0359 682 6820 TRUE 1.44490555142168 0.0845 0.0403 0.0907 0.117 0.439 1.09 0.87 1.38 0.116 0.117 0.318 1.12 0.894 1.41 0.256 0.114 0.0245 1.29 1.03 1.62 ukb-melanoma-latest-gwas all 528.6 Leukoplakia of oral mucosa Digestive Both 1.06 0.941 1.19 0.341 308 3080 FALSE 0.467245621007502 0.0569 0.0598 0.0266 0.173 0.877 1.03 0.73 1.45 0.106 0.17 0.534 1.11 0.795 1.56 0.169 0.168 0.316 1.18 0.85 1.65 ukb-melanoma-latest-gwas all 528.7 Sialolithiasis Digestive Both 0.977 0.87 1.1 0.692 314 3140 FALSE 0.159893905543242 -0.0234 0.0591 -0.558 0.174 0.00136 0.572 0.404 0.804 -0.277 0.162 0.0874 0.758 0.55 1.04 -0.0861 0.155 0.58 0.918 0.675 1.25 ukb-melanoma-latest-gwas all 528.11 Stomatitis and mucositis (ulcerative) Digestive Both 1.1 0.989 1.22 0.0805 390 3900 FALSE 1.09420411963213 0.0932 0.0533 0.00927 0.154 0.952 1.01 0.744 1.37 0.0226 0.154 0.884 1.02 0.754 1.39 0.268 0.148 0.0694 1.31 0.979 1.75 ukb-melanoma-latest-gwas all 528.12 Oral aphthae Digestive Both 0.914 0.728 1.15 0.434 84 840 FALSE 0.362510270487489 -0.0896 0.114 -0.554 0.325 0.0881 0.575 0.294 1.09 -0.116 0.295 0.694 0.89 0.494 1.6 -0.405 0.318 0.202 0.667 0.349 1.25 ukb-melanoma-latest-gwas all 528.41 Cyst of the salivary gland Digestive Both 0.951 0.769 1.18 0.641 94 940 FALSE 0.193141970481183 -0.0499 0.107 -0.0468 0.293 0.873 0.954 0.53 1.71 -0.652 0.339 0.0542 0.521 0.257 1.01 0.165 0.278 0.552 1.18 0.681 2.06 ukb-melanoma-latest-gwas all 529 Diseases and other conditions of the tongue Digestive Both 1.01 0.955 1.07 0.67 1235 12344 FALSE 0.173925197299174 0.0127 0.0299 0.0165 0.0845 0.845 1.02 0.861 1.2 0.0104 0.0847 0.903 1.01 0.856 1.19 0.0106 0.0851 0.901 1.01 0.855 1.19 ukb-melanoma-latest-gwas all 529.1 Glossitis Digestive Both 1.1 0.973 1.24 0.132 299 2990 FALSE 0.87942606879415 0.0916 0.0607 0.0915 0.175 0.601 1.1 0.776 1.55 0.122 0.174 0.484 1.13 0.801 1.6 0.21 0.172 0.224 1.23 0.879 1.74 ukb-melanoma-latest-gwas all 530 Diseases of esophagus Digestive Both 1.02 1.01 1.03 0.00387 33704 280049 TRUE 2.41228903498109 0.0168 0.0058 0.0153 0.0165 0.356 1.02 0.983 1.05 0.0709 0.0164 1.48e-05 1.07 1.04 1.11 0.0369 0.0165 0.0255 1.04 1 1.07 ukb-melanoma-latest-gwas all 530.1 Esophagitis, GERD and related diseases Digestive Both 1.02 1 1.03 0.0118 31312 260239 TRUE 1.92811799269387 0.0151 0.00602 0.0181 0.0172 0.291 1.02 0.985 1.05 0.0739 0.017 1.33e-05 1.08 1.04 1.11 0.0341 0.0172 0.0471 1.03 1 1.07 ukb-melanoma-latest-gwas all 530.2 Esophageal bleeding (varices/hemorrhage) Digestive Both 1.04 0.991 1.1 0.108 1683 16830 FALSE 0.96657624451305 0.0413 0.0257 -0.0188 0.0739 0.799 0.981 0.849 1.13 0.0913 0.0723 0.207 1.1 0.951 1.26 0.0854 0.0727 0.24 1.09 0.944 1.26 ukb-melanoma-latest-gwas all 530.3 Stricture and stenosis of esophagus Digestive Both 1.01 0.967 1.06 0.55 1873 18730 FALSE 0.259637310505756 0.0146 0.0244 -0.0399 0.069 0.564 0.961 0.839 1.1 0.0624 0.0676 0.357 1.06 0.932 1.22 -0.0454 0.0695 0.514 0.956 0.834 1.1 ukb-melanoma-latest-gwas all 530.5 Disorders of esophageal motility Digestive Both 0.992 0.914 1.08 0.839 638 6380 FALSE 0.0762380391712997 -0.00845 0.0416 -0.029 0.118 0.806 0.971 0.77 1.23 0.0581 0.116 0.616 1.06 0.844 1.33 -0.00139 0.118 0.991 0.999 0.791 1.26 ukb-melanoma-latest-gwas all 530.6 Diverticulum of esophagus, acquired Digestive Both 0.975 0.826 1.15 0.767 153 1529 FALSE 0.115204636051019 -0.0251 0.0845 -0.359 0.245 0.142 0.698 0.426 1.13 -0.0244 0.227 0.915 0.976 0.622 1.53 -0.176 0.234 0.453 0.839 0.526 1.33 ukb-melanoma-latest-gwas all 530.7 Gastroesophageal laceration-hemorrhage syndrome Digestive Both 0.963 0.861 1.08 0.502 344 3440 FALSE 0.299296282854981 -0.038 0.0567 -0.321 0.163 0.0491 0.725 0.524 0.999 -0.00628 0.152 0.967 0.994 0.737 1.34 -0.151 0.158 0.341 0.86 0.629 1.17 ukb-melanoma-latest-gwas all 530.9 Heartburn Digestive Both 1.04 0.992 1.09 0.106 2096 20960 FALSE 0.97469413473523 0.0372 0.023 -0.00326 0.0658 0.961 0.997 0.876 1.13 0.0642 0.0648 0.322 1.07 0.939 1.21 0.0581 0.0652 0.373 1.06 0.933 1.2 ukb-melanoma-latest-gwas all 530.11 GERD Digestive Both 1.02 1 1.04 0.0385 14058 140580 TRUE 1.4145392704915 0.0184 0.00888 0.0455 0.0253 0.0718 1.05 0.996 1.1 0.0893 0.0251 0.000368 1.09 1.04 1.15 0.0331 0.0254 0.193 1.03 0.983 1.09 ukb-melanoma-latest-gwas all 530.12 Ulcer of esophagus Digestive Both 1.01 0.978 1.04 0.689 5219 52184 FALSE 0.161780778092374 0.00584 0.0146 0.0181 0.0414 0.662 1.02 0.939 1.1 0.0464 0.0412 0.261 1.05 0.966 1.14 0.031 0.0415 0.455 1.03 0.951 1.12 ukb-melanoma-latest-gwas all 530.14 Reflux esophagitis Digestive Both 0.995 0.976 1.02 0.657 10473 104727 FALSE 0.182434630440219 -0.00457 0.0103 0.0102 0.0291 0.727 1.01 0.954 1.07 0.0433 0.0289 0.135 1.04 0.987 1.11 -4.58e-05 0.0293 0.999 1 0.944 1.06 ukb-melanoma-latest-gwas all 531 Peptic ulcer (excl. esophageal) Digestive Both 1.01 0.986 1.03 0.419 7421 74192 FALSE 0.377785977033705 0.00989 0.0122 0.0287 0.0347 0.407 1.03 0.962 1.1 0.033 0.0347 0.341 1.03 0.966 1.11 0.0385 0.0348 0.268 1.04 0.971 1.11 ukb-melanoma-latest-gwas all 531.1 Hemorrhage from gastrointestinal ulcer Digestive Both 1.02 0.943 1.11 0.584 634 6340 FALSE 0.233587152887601 0.0229 0.0418 -0.00693 0.116 0.952 0.993 0.79 1.25 -0.122 0.119 0.308 0.886 0.7 1.12 0.00166 0.117 0.989 1 0.796 1.26 ukb-melanoma-latest-gwas all 531.2 Gastric ulcer Digestive Both 1 0.971 1.04 0.859 4099 40979 FALSE 0.0660068361687577 0.00292 0.0165 -0.0255 0.0467 0.585 0.975 0.89 1.07 0.00666 0.0464 0.886 1.01 0.919 1.1 0.0246 0.0464 0.596 1.02 0.936 1.12 ukb-melanoma-latest-gwas all 531.3 Duodenal ulcer Digestive Both 1 0.963 1.04 0.981 2994 29933 FALSE 0.0083309926200515 0.000452 0.0193 0.0583 0.0546 0.285 1.06 0.953 1.18 0.0923 0.0542 0.0886 1.1 0.986 1.22 0.0028 0.0555 0.96 1 0.899 1.12 ukb-melanoma-latest-gwas all 531.4 Peptic ulcer, site unspecified Digestive Both 1.06 0.956 1.17 0.28 424 4240 FALSE 0.552841968657781 0.0553 0.0511 -0.00405 0.143 0.977 0.996 0.752 1.32 -0.167 0.149 0.263 0.846 0.63 1.13 0.0565 0.141 0.688 1.06 0.802 1.4 ukb-melanoma-latest-gwas all 532 Dysphagia Digestive Both 1.02 0.997 1.05 0.079 6447 64466 FALSE 1.10237290870956 0.0231 0.0131 0.0323 0.0371 0.384 1.03 0.96 1.11 0.0224 0.0373 0.548 1.02 0.951 1.1 0.0431 0.0372 0.247 1.04 0.971 1.12 ukb-melanoma-latest-gwas all 535 Gastritis and duodenitis Digestive Both 1.01 1 1.03 0.0426 28309 262547 TRUE 1.37059040089728 0.0127 0.00629 0.0204 0.0179 0.253 1.02 0.985 1.06 0.0318 0.0178 0.0748 1.03 0.997 1.07 0.0388 0.0179 0.0299 1.04 1 1.08 ukb-melanoma-latest-gwas all 535.1 Acute gastritis Digestive Both 1.02 0.958 1.08 0.585 1185 11850 FALSE 0.23284413391782 0.0167 0.0306 0.0318 0.0869 0.715 1.03 0.87 1.22 0.0241 0.0871 0.782 1.02 0.863 1.22 0.0795 0.0864 0.357 1.08 0.914 1.28 ukb-melanoma-latest-gwas all 535.2 Atrophic gastritis Digestive Both 1.04 0.938 1.16 0.43 370 3690 FALSE 0.366531544420413 0.043 0.0546 0.000152 0.158 0.999 1 0.733 1.37 0.0979 0.155 0.529 1.1 0.812 1.5 0.167 0.154 0.277 1.18 0.874 1.6 ukb-melanoma-latest-gwas all 535.6 Duodenitis Digestive Both 1 0.978 1.03 0.913 7605 76045 FALSE 0.039529222465701 0.00131 0.0121 -0.0275 0.0342 0.422 0.973 0.91 1.04 -0.0128 0.0341 0.707 0.987 0.923 1.06 0.01 0.034 0.769 1.01 0.945 1.08 ukb-melanoma-latest-gwas all 535.8 Other specified gastritis Digestive Both 0.995 0.972 1.02 0.646 8094 80940 FALSE 0.189767482004916 -0.00538 0.0117 0.0383 0.033 0.245 1.04 0.974 1.11 0.025 0.0331 0.45 1.03 0.961 1.09 -0.00539 0.0335 0.872 0.995 0.931 1.06 ukb-melanoma-latest-gwas all 535.9 Gastritis and duodenitis, NOS Digestive Both 0.931 0.773 1.12 0.453 120 1192 FALSE 0.343901797987168 -0.071 0.0947 -0.589 0.282 0.0371 0.555 0.311 0.964 -0.116 0.247 0.637 0.89 0.545 1.45 -0.323 0.259 0.213 0.724 0.43 1.21 ukb-melanoma-latest-gwas all 536 Disorders of function of stomach Digestive Both 1.1 0.969 1.25 0.139 268 2666 FALSE 0.856985199745905 0.0952 0.0643 0.00613 0.195 0.975 1.01 0.684 1.48 0.41 0.18 0.0231 1.51 1.06 2.16 0.288 0.188 0.125 1.33 0.922 1.94 ukb-melanoma-latest-gwas all 536.8 Dyspepsia and other specified disorders of function of stomach Digestive Both 1.09 0.961 1.24 0.173 259 2576 FALSE 0.761953896871205 0.0891 0.0653 0.0442 0.197 0.823 1.05 0.708 1.55 0.392 0.184 0.033 1.48 1.03 2.14 0.283 0.192 0.139 1.33 0.911 1.94 ukb-melanoma-latest-gwas all 537 Other disorders of stomach and duodenum Digestive Both 1.03 0.995 1.07 0.0958 3400 33994 FALSE 1.01863449092146 0.0301 0.0181 0.0909 0.0515 0.0774 1.1 0.99 1.21 0.0918 0.0515 0.075 1.1 0.991 1.21 0.0878 0.0517 0.0895 1.09 0.987 1.21 ukb-melanoma-latest-gwas all 540 Appendiceal conditions Digestive Both 0.979 0.945 1.01 0.246 3409 34084 FALSE 0.609064892896621 -0.0209 0.018 -0.0261 0.0508 0.607 0.974 0.882 1.08 -0.0123 0.0507 0.809 0.988 0.894 1.09 -0.0324 0.051 0.525 0.968 0.876 1.07 ukb-melanoma-latest-gwas all 540.1 Appendicitis Digestive Both 0.979 0.944 1.02 0.255 3217 32164 FALSE 0.593459819566045 -0.0211 0.0185 -0.0368 0.0523 0.481 0.964 0.87 1.07 -0.014 0.0521 0.789 0.986 0.89 1.09 -0.0343 0.0525 0.514 0.966 0.872 1.07 ukb-melanoma-latest-gwas all 540.11 Acute appendicitis Digestive Both 0.98 0.941 1.02 0.327 2607 26064 FALSE 0.485452247339714 -0.0202 0.0206 -0.00846 0.0583 0.885 0.992 0.884 1.11 0.0325 0.0578 0.574 1.03 0.922 1.16 -0.0272 0.0587 0.643 0.973 0.867 1.09 ukb-melanoma-latest-gwas all 550 Abdominal hernia Digestive Both 1.01 0.999 1.02 0.0742 45931 283394 FALSE 1.12959609472097 0.00912 0.00511 0.0174 0.0144 0.229 1.02 0.989 1.05 0.00417 0.0145 0.774 1 0.976 1.03 0.0295 0.0145 0.0416 1.03 1 1.06 ukb-melanoma-latest-gwas all 550.1 Inguinal hernia Digestive Both 0.995 0.979 1.01 0.574 15818 123480 FALSE 0.241088107602026 -0.00478 0.0085 -0.0136 0.0239 0.569 0.987 0.941 1.03 -0.0575 0.0241 0.0171 0.944 0.901 0.99 -0.00949 0.0239 0.692 0.991 0.945 1.04 ukb-melanoma-latest-gwas all 550.2 Diaphragmatic hernia Digestive Both 1.02 1.01 1.04 0.000798 26560 239425 TRUE 3.09799710864927 0.0218 0.0065 0.0236 0.0185 0.202 1.02 0.987 1.06 0.0464 0.0185 0.0118 1.05 1.01 1.09 0.0574 0.0185 0.00188 1.06 1.02 1.1 ukb-melanoma-latest-gwas all 550.3 Femoral hernia Digestive Both 0.979 0.903 1.06 0.6 651 6510 FALSE 0.221848749616356 -0.0216 0.0412 -0.181 0.117 0.122 0.834 0.662 1.05 -0.0988 0.115 0.39 0.906 0.722 1.14 -0.0582 0.114 0.611 0.943 0.754 1.18 ukb-melanoma-latest-gwas all 550.4 Umbilical hernia Digestive Both 0.995 0.962 1.03 0.788 3713 37130 FALSE 0.103473782510445 -0.00465 0.0173 0.0522 0.0482 0.279 1.05 0.959 1.16 -0.0778 0.0496 0.117 0.925 0.839 1.02 0.0255 0.0487 0.6 1.03 0.932 1.13 ukb-melanoma-latest-gwas all 550.5 Ventral hernia Digestive Both 1.02 0.989 1.06 0.188 3441 34410 FALSE 0.72584215073632 0.0237 0.018 0.0522 0.0504 0.301 1.05 0.954 1.16 -0.0846 0.0522 0.105 0.919 0.829 1.02 0.102 0.0502 0.042 1.11 1 1.22 ukb-melanoma-latest-gwas all 555 Inflammatory bowel disease and other gastroenteritis and colitis Digestive Both 1 0.97 1.03 0.964 4504 45040 FALSE 0.0159229660971692 0.00071 0.0157 -0.0273 0.0447 0.541 0.973 0.891 1.06 0.0599 0.0438 0.172 1.06 0.974 1.16 -0.00826 0.0447 0.854 0.992 0.908 1.08 ukb-melanoma-latest-gwas all 555.1 Regional enteritis Digestive Both 0.986 0.938 1.04 0.578 1731 17310 FALSE 0.238072161579471 -0.0141 0.0253 -0.217 0.0726 0.00281 0.805 0.698 0.928 -0.0245 0.0694 0.724 0.976 0.852 1.12 -0.073 0.0706 0.301 0.93 0.809 1.07 ukb-melanoma-latest-gwas all 555.2 Ulcerative colitis Digestive Both 1.01 0.971 1.04 0.713 3182 31820 FALSE 0.146910470148134 0.00687 0.0187 0.0303 0.0533 0.57 1.03 0.928 1.14 0.115 0.0524 0.028 1.12 1.01 1.24 0.0169 0.0538 0.753 1.02 0.915 1.13 ukb-melanoma-latest-gwas all 555.21 Ulcerative colitis (chronic) Digestive Both 1.02 0.935 1.12 0.63 538 5380 FALSE 0.200659450546418 0.0218 0.0453 -0.048 0.13 0.711 0.953 0.738 1.23 0.1 0.126 0.425 1.11 0.864 1.42 -0.00379 0.129 0.977 0.996 0.773 1.28 ukb-melanoma-latest-gwas all 556 Ulceration of the lower GI tract Digestive Both 1.01 0.95 1.08 0.718 1062 10620 FALSE 0.1438755557577 0.0117 0.0324 -0.177 0.092 0.0539 0.837 0.699 1 -0.138 0.0912 0.129 0.871 0.728 1.04 0.0386 0.0885 0.662 1.04 0.874 1.24 ukb-melanoma-latest-gwas all 556.1 Ulceration of intestine Digestive Both 0.987 0.912 1.07 0.757 673 6730 FALSE 0.120904120499927 -0.0126 0.0407 -0.18 0.115 0.117 0.835 0.666 1.05 -0.138 0.113 0.222 0.871 0.697 1.09 -0.0164 0.112 0.884 0.984 0.789 1.23 ukb-melanoma-latest-gwas all 557 Intestinal malabsorption (non-celiac) Digestive Both 1.04 0.924 1.17 0.511 301 3010 FALSE 0.291579099865287 0.0398 0.0605 0.07 0.168 0.678 1.07 0.77 1.5 -0.0987 0.174 0.57 0.906 0.642 1.28 0.0196 0.17 0.908 1.02 0.729 1.43 ukb-melanoma-latest-gwas all 558 Noninfectious gastroenteritis Digestive Both 1.02 1 1.04 0.02 15594 155922 TRUE 1.69897000433602 0.0196 0.00844 0.0156 0.024 0.515 1.02 0.969 1.06 0.0451 0.0239 0.0586 1.05 0.998 1.1 0.0492 0.0239 0.0399 1.05 1 1.1 ukb-melanoma-latest-gwas all 559 Ileostomy status Digestive Both 0.96 0.913 1.01 0.117 1659 16590 FALSE 0.931814138253838 -0.0405 0.0258 -0.00613 0.0717 0.932 0.994 0.863 1.14 -0.0383 0.0723 0.597 0.962 0.835 1.11 -0.12 0.0739 0.104 0.887 0.767 1.02 ukb-melanoma-latest-gwas all 560 Intestinal obstruction without mention of hernia Digestive Both 1.01 0.977 1.04 0.591 4006 40053 FALSE 0.228412519118745 0.00893 0.0166 0.0305 0.0473 0.518 1.03 0.94 1.13 0.0576 0.047 0.221 1.06 0.966 1.16 0.041 0.0474 0.387 1.04 0.949 1.14 ukb-melanoma-latest-gwas all 560.1 Paralytic ileus Digestive Both 1.07 0.979 1.17 0.133 523 5230 FALSE 0.876148359032914 0.0693 0.0462 0.118 0.135 0.383 1.13 0.862 1.47 0.23 0.133 0.0827 1.26 0.97 1.64 0.289 0.132 0.0287 1.34 1.03 1.73 ukb-melanoma-latest-gwas all 560.2 Impaction of intestine Digestive Both 0.941 0.83 1.07 0.345 268 2680 FALSE 0.462180904926726 -0.0604 0.064 0.0421 0.174 0.809 1.04 0.74 1.47 -0.269 0.187 0.15 0.764 0.526 1.1 -0.0341 0.178 0.848 0.967 0.68 1.37 ukb-melanoma-latest-gwas all 560.3 Peritoneal or intestinal adhesions Digestive Both 1.05 0.981 1.13 0.152 831 8310 FALSE 0.818156412055227 0.0523 0.0365 0.218 0.104 0.0366 1.24 1.01 1.53 0.0887 0.107 0.408 1.09 0.885 1.35 0.229 0.105 0.0283 1.26 1.02 1.55 ukb-melanoma-latest-gwas all 560.4 Other intestinal obstruction Digestive Both 1.01 0.972 1.04 0.701 3362 33616 FALSE 0.154281982033341 0.00697 0.0182 0.0147 0.0514 0.776 1.01 0.917 1.12 0.0417 0.0512 0.415 1.04 0.943 1.15 0.00987 0.0518 0.849 1.01 0.912 1.12 ukb-melanoma-latest-gwas all 561 Symptoms involving digestive system Digestive Both 1.01 0.99 1.02 0.463 15809 158086 FALSE 0.334419008982047 0.00615 0.00838 0.00518 0.0237 0.827 1.01 0.96 1.05 0.00856 0.0237 0.718 1.01 0.963 1.06 0.0309 0.0237 0.192 1.03 0.985 1.08 ukb-melanoma-latest-gwas all 561.1 Diarrhea Digestive Both 1.04 0.948 1.15 0.381 466 4660 FALSE 0.419075024324381 0.0426 0.0487 -0.0446 0.142 0.753 0.956 0.723 1.26 0.119 0.137 0.384 1.13 0.861 1.48 0.142 0.136 0.298 1.15 0.881 1.51 ukb-melanoma-latest-gwas all 561.2 Flatulence Digestive Both 1.04 0.989 1.09 0.131 1688 16880 FALSE 0.882728704344236 0.0387 0.0256 0.139 0.073 0.0575 1.15 0.996 1.33 0.071 0.0742 0.338 1.07 0.928 1.24 0.152 0.0732 0.0379 1.16 1.01 1.34 ukb-melanoma-latest-gwas all 562 Diverticulosis and diverticulitis Digestive Both 1.01 1 1.03 0.0322 26751 211994 TRUE 1.49214412830417 0.014 0.00654 0.00453 0.0186 0.808 1 0.969 1.04 0.0325 0.0185 0.0796 1.03 0.996 1.07 0.0466 0.0185 0.0119 1.05 1.01 1.09 ukb-melanoma-latest-gwas all 562.1 Diverticulosis Digestive Both 1.01 1 1.03 0.0326 26709 211935 TRUE 1.48678239993206 0.014 0.00655 0.00447 0.0186 0.81 1 0.968 1.04 0.0321 0.0185 0.0831 1.03 0.996 1.07 0.0464 0.0185 0.0122 1.05 1.01 1.09 ukb-melanoma-latest-gwas all 563 Constipation Digestive Both 1 0.98 1.02 0.993 10350 103421 FALSE 0.00305075150461883 9.22e-05 0.0104 0.0251 0.0292 0.39 1.03 0.968 1.09 0.0295 0.0292 0.313 1.03 0.973 1.09 0.0038 0.0295 0.897 1 0.947 1.06 ukb-melanoma-latest-gwas all 564 Functional digestive disorders Digestive Both 1.01 0.994 1.02 0.292 21783 210993 FALSE 0.534617148551582 0.00754 0.00715 0.00471 0.0203 0.817 1 0.965 1.05 0.031 0.0202 0.125 1.03 0.991 1.07 0.0338 0.0203 0.096 1.03 0.994 1.08 ukb-melanoma-latest-gwas all 564.1 Irritable Bowel Syndrome Digestive Both 1.01 0.986 1.04 0.347 5522 55220 FALSE 0.459670525209126 0.0133 0.0142 0.0622 0.0402 0.122 1.06 0.983 1.15 0.0519 0.0404 0.199 1.05 0.973 1.14 0.0669 0.0404 0.0974 1.07 0.988 1.16 ukb-melanoma-latest-gwas all 564.8 Abnormal findings on exam of gastrointestinal tract/ abdominal area Digestive Both 0.993 0.944 1.05 0.796 1649 16490 FALSE 0.0990869322623309 -0.00671 0.0259 -0.0737 0.0732 0.314 0.929 0.805 1.07 -0.0429 0.0727 0.555 0.958 0.831 1.1 -0.0195 0.0728 0.789 0.981 0.85 1.13 ukb-melanoma-latest-gwas all 564.9 Personal history of diseases of digestive system Digestive Both 1.01 0.996 1.03 0.127 15221 151974 FALSE 0.896196279044043 0.0131 0.00854 0.00343 0.0243 0.888 1 0.957 1.05 0.0386 0.0241 0.109 1.04 0.991 1.09 0.0404 0.0242 0.0948 1.04 0.993 1.09 ukb-melanoma-latest-gwas all 565 Anal and rectal conditions Digestive Both 0.994 0.977 1.01 0.463 14862 148609 FALSE 0.334419008982047 -0.00634 0.00864 0.00966 0.0243 0.691 1.01 0.963 1.06 -0.00556 0.0244 0.82 0.994 0.948 1.04 -0.0105 0.0245 0.668 0.99 0.943 1.04 ukb-melanoma-latest-gwas all 565.1 Anal and rectal polyp Digestive Both 1 0.98 1.03 0.77 7341 73408 FALSE 0.113509274827518 0.0036 0.0123 0.00348 0.0348 0.92 1 0.937 1.07 0.024 0.0347 0.489 1.02 0.957 1.1 0.0197 0.0349 0.573 1.02 0.952 1.09 ukb-melanoma-latest-gwas all 567 Peritonitis and retroperitoneal infections Digestive Both 0.979 0.915 1.05 0.538 932 9320 FALSE 0.269217724333611 -0.0212 0.0345 0.174 0.0972 0.0739 1.19 0.983 1.44 0.132 0.0981 0.179 1.14 0.941 1.38 0.0196 0.101 0.846 1.02 0.836 1.24 ukb-melanoma-latest-gwas all 568 Other disorders of peritoneum Digestive Both 1.01 0.975 1.05 0.554 3309 33090 FALSE 0.25649023527157 0.0109 0.0183 0.0539 0.0517 0.297 1.06 0.954 1.17 0.0316 0.052 0.544 1.03 0.932 1.14 0.0224 0.0522 0.668 1.02 0.923 1.13 ukb-melanoma-latest-gwas all 568.1 Peritoneal adhesions (postoperative) (postinfection) Digestive Both 1.01 0.97 1.05 0.708 3102 31020 FALSE 0.149966742310231 0.00709 0.0189 0.0589 0.0532 0.268 1.06 0.956 1.18 0.00984 0.0539 0.855 1.01 0.909 1.12 0.0167 0.0539 0.756 1.02 0.915 1.13 ukb-melanoma-latest-gwas all 569 Other disorders of intestine Digestive Both 0.995 0.964 1.03 0.778 4218 42180 FALSE 0.109020403010311 -0.00457 0.0162 0.00144 0.0456 0.975 1 0.916 1.1 -0.00909 0.0458 0.843 0.991 0.906 1.08 -0.000245 0.0459 0.996 1 0.914 1.09 ukb-melanoma-latest-gwas all 569.1 Toxic gastroenteritis and colitis Digestive Both 0.982 0.83 1.16 0.833 149 1490 FALSE 0.0793549985932124 -0.018 0.0855 -0.19 0.245 0.438 0.827 0.506 1.34 -0.0241 0.235 0.919 0.976 0.611 1.56 -0.0109 0.236 0.963 0.989 0.62 1.58 ukb-melanoma-latest-gwas all 569.2 Gastrointestinal complications Digestive Both 0.954 0.869 1.05 0.325 484 4840 FALSE 0.488116639021126 -0.0469 0.0477 -0.14 0.135 0.3 0.87 0.666 1.13 -0.078 0.133 0.558 0.925 0.712 1.2 -0.0423 0.132 0.749 0.959 0.739 1.24 ukb-melanoma-latest-gwas all 571 Chronic liver disease and cirrhosis Digestive Both 1.03 0.996 1.07 0.0829 2984 29840 FALSE 1.08144546944973 0.0335 0.0193 0.0863 0.0553 0.119 1.09 0.978 1.22 0.133 0.0548 0.0153 1.14 1.03 1.27 0.099 0.0554 0.0743 1.1 0.99 1.23 ukb-melanoma-latest-gwas all 571.5 Other chronic nonalcoholic liver disease Digestive Both 1.02 0.97 1.07 0.453 1699 16990 FALSE 0.343901797987168 0.0192 0.0255 0.094 0.0725 0.195 1.1 0.953 1.27 0.105 0.0724 0.147 1.11 0.964 1.28 0.0499 0.0735 0.497 1.05 0.91 1.21 ukb-melanoma-latest-gwas all 571.6 Primary biliary cirrhosis Digestive Both 1.13 0.991 1.28 0.0683 256 2560 FALSE 1.16557929631847 0.12 0.0658 -0.109 0.199 0.584 0.897 0.603 1.33 0.227 0.185 0.221 1.25 0.871 1.81 0.296 0.183 0.105 1.35 0.94 1.94 ukb-melanoma-latest-gwas all 571.8 Liver abscess and sequelae of chronic liver disease Digestive Both 1.05 0.98 1.12 0.174 987 9870 FALSE 0.7594507517174 0.0458 0.0336 0.153 0.0971 0.114 1.17 0.964 1.41 0.182 0.0966 0.0591 1.2 0.993 1.45 0.176 0.0971 0.0698 1.19 0.986 1.44 ukb-melanoma-latest-gwas all 571.51 Cirrhosis of liver without mention of alcohol Digestive Both 0.786 0.647 0.954 0.014 115 1150 TRUE 1.85387196432176 -0.241 0.0981 -0.319 0.261 0.222 0.727 0.43 1.21 -0.194 0.253 0.443 0.824 0.497 1.36 -0.811 0.294 0.00587 0.444 0.243 0.787 ukb-melanoma-latest-gwas all 571.81 Portal hypertension Digestive Both 1.07 0.982 1.18 0.116 532 5320 FALSE 0.935542010773082 0.0721 0.0458 0.107 0.133 0.423 1.11 0.856 1.45 0.151 0.132 0.252 1.16 0.898 1.51 0.243 0.13 0.0619 1.28 0.988 1.65 ukb-melanoma-latest-gwas all 572 Ascites (non malignant) Digestive Both 1.02 0.967 1.07 0.488 1548 15480 FALSE 0.311580177997289 0.0185 0.0268 0.00675 0.0758 0.929 1.01 0.868 1.17 0.0443 0.0753 0.557 1.05 0.902 1.21 0.0122 0.0761 0.872 1.01 0.872 1.18 ukb-melanoma-latest-gwas all 573 Other disorders of liver Digestive Both 1.01 0.958 1.07 0.702 1505 15045 FALSE 0.153662887870195 0.0104 0.0272 -0.0425 0.0763 0.578 0.958 0.825 1.11 -0.0804 0.077 0.297 0.923 0.793 1.07 0.00274 0.0759 0.971 1 0.864 1.16 ukb-melanoma-latest-gwas all 573.5 Jaundice (not of newborn) Digestive Both 0.92 0.703 1.21 0.54 59 590 FALSE 0.267606240177031 -0.0829 0.135 -0.432 0.381 0.256 0.649 0.296 1.38 -0.18 0.355 0.612 0.835 0.408 1.7 -0.412 0.381 0.28 0.663 0.304 1.41 ukb-melanoma-latest-gwas all 573.7 Abnormal results of function study of liver Digestive Both 1.01 0.855 1.19 0.927 156 1555 FALSE 0.0329202658555029 0.00767 0.0834 -0.292 0.243 0.23 0.747 0.458 1.21 -0.201 0.236 0.394 0.818 0.51 1.3 0.12 0.221 0.586 1.13 0.729 1.75 ukb-melanoma-latest-gwas all 574 Cholelithiasis and cholecystitis Digestive Both 0.998 0.982 1.01 0.838 16011 160020 FALSE 0.0767559813697235 -0.0017 0.00832 0.0109 0.0235 0.644 1.01 0.965 1.06 0.0143 0.0235 0.542 1.01 0.969 1.06 0.00921 0.0236 0.697 1.01 0.964 1.06 ukb-melanoma-latest-gwas all 574.1 Cholelithiasis Digestive Both 0.996 0.979 1.01 0.674 13618 136158 FALSE 0.17134010346468 -0.0038 0.00903 0.00911 0.0255 0.721 1.01 0.96 1.06 0.0193 0.0255 0.448 1.02 0.97 1.07 0.00356 0.0257 0.89 1 0.954 1.06 ukb-melanoma-latest-gwas all 574.2 Calculus of bile duct Digestive Both 1.01 0.969 1.05 0.665 2627 26264 FALSE 0.177178354696895 0.00891 0.0206 0.0882 0.058 0.128 1.09 0.975 1.22 0.0489 0.0586 0.404 1.05 0.936 1.18 0.0441 0.059 0.455 1.05 0.931 1.17 ukb-melanoma-latest-gwas all 574.3 Cholecystitis without cholelithiasis Digestive Both 1 0.962 1.04 0.962 2759 27590 FALSE 0.0168249279621871 0.000955 0.0201 -0.0218 0.0564 0.699 0.978 0.876 1.09 -0.0259 0.0565 0.647 0.974 0.872 1.09 -0.00653 0.0566 0.908 0.993 0.889 1.11 ukb-melanoma-latest-gwas all 574.11 Cholelithiasis with acute cholecystitis Digestive Both 1.01 0.953 1.06 0.85 1511 15110 FALSE 0.0705810742857073 0.00511 0.0271 0.000747 0.0766 0.992 1 0.861 1.16 0.016 0.0763 0.834 1.02 0.875 1.18 0.0156 0.0767 0.839 1.02 0.874 1.18 ukb-melanoma-latest-gwas all 574.12 Cholelithiasis with other cholecystitis Digestive Both 0.983 0.956 1.01 0.22 5437 54370 FALSE 0.657577319177794 -0.0175 0.0143 0.0212 0.0402 0.597 1.02 0.944 1.11 0.0384 0.04 0.337 1.04 0.961 1.12 -0.0427 0.0409 0.296 0.958 0.884 1.04 ukb-melanoma-latest-gwas all 575 Other biliary tract disease Digestive Both 1.02 0.984 1.05 0.307 3897 38970 FALSE 0.512861624522813 0.0172 0.0169 0.0267 0.0478 0.576 1.03 0.935 1.13 0.0388 0.0477 0.416 1.04 0.947 1.14 0.0336 0.048 0.484 1.03 0.941 1.14 ukb-melanoma-latest-gwas all 575.1 Cholangitis Digestive Both 1 0.914 1.1 0.946 495 4950 FALSE 0.0241088635982073 0.0032 0.0473 0.0556 0.133 0.676 1.06 0.814 1.37 0.0286 0.134 0.831 1.03 0.791 1.34 0.00362 0.135 0.979 1 0.77 1.31 ukb-melanoma-latest-gwas all 575.2 Obstruction of bile duct Digestive Both 0.964 0.895 1.04 0.325 777 7770 FALSE 0.488116639021126 -0.0371 0.0377 -0.164 0.106 0.122 0.848 0.688 1.05 -0.00633 0.103 0.951 0.994 0.812 1.22 -0.17 0.107 0.114 0.844 0.683 1.04 ukb-melanoma-latest-gwas all 575.6 Cholesterolosis of gallbladder Digestive Both 1.01 0.916 1.11 0.865 457 4570 FALSE 0.0629838925351858 0.00837 0.0492 0.0478 0.136 0.724 1.05 0.803 1.37 -0.15 0.142 0.292 0.861 0.65 1.14 0.0331 0.137 0.81 1.03 0.789 1.35 ukb-melanoma-latest-gwas all 575.7 Other disorders of gallbladder Digestive Both 1.05 0.995 1.11 0.0723 1410 14100 FALSE 1.14086170270547 0.0504 0.028 0.088 0.081 0.278 1.09 0.932 1.28 0.164 0.0798 0.0396 1.18 1.01 1.38 0.13 0.0805 0.105 1.14 0.973 1.33 ukb-melanoma-latest-gwas all 575.8 Other disorders of biliary tract Digestive Both 1.08 1.02 1.16 0.0139 1037 10370 TRUE 1.85698519974591 0.0805 0.0327 0.109 0.0938 0.245 1.12 0.928 1.34 0.0837 0.0946 0.376 1.09 0.903 1.31 0.183 0.0927 0.0481 1.2 1 1.44 ukb-melanoma-latest-gwas all 575.9 Nonspecific abnormal findings on radiological and other examination of biliary tract Digestive Both 0.998 0.894 1.11 0.975 349 3490 FALSE 0.0109953843014632 -0.00176 0.0561 0.0105 0.159 0.947 1.01 0.739 1.38 -0.0424 0.161 0.792 0.958 0.698 1.32 0.0489 0.157 0.756 1.05 0.771 1.43 ukb-melanoma-latest-gwas all 577 Diseases of pancreas Digestive Both 1.02 0.978 1.06 0.385 2702 27020 FALSE 0.414539270491499 0.0176 0.0203 -0.00474 0.0574 0.934 0.995 0.889 1.11 -0.00849 0.0575 0.883 0.992 0.886 1.11 0.0502 0.057 0.379 1.05 0.94 1.18 ukb-melanoma-latest-gwas all 577.1 Acute pancreatitis Digestive Both 1.02 0.976 1.07 0.359 1996 19960 FALSE 0.444905551421681 0.0216 0.0236 -0.0434 0.067 0.518 0.958 0.84 1.09 -0.0107 0.0666 0.872 0.989 0.868 1.13 0.0487 0.0661 0.461 1.05 0.922 1.2 ukb-melanoma-latest-gwas all 577.2 Chronic pancreatitis Digestive Both 1.05 0.954 1.14 0.342 514 5140 FALSE 0.465973893943865 0.044 0.0464 -0.0565 0.133 0.671 0.945 0.727 1.23 -0.0383 0.133 0.774 0.962 0.74 1.25 0.163 0.128 0.202 1.18 0.916 1.51 ukb-melanoma-latest-gwas all 577.3 Cyst and pseudocyst of pancreas Digestive Both 0.93 0.835 1.04 0.19 363 3630 FALSE 0.721246399047171 -0.0724 0.0552 -0.00462 0.149 0.975 0.995 0.742 1.34 -0.266 0.159 0.0943 0.767 0.559 1.05 -0.139 0.154 0.368 0.87 0.642 1.18 ukb-melanoma-latest-gwas all 578 Gastrointestinal hemorrhage Digestive Both 1 0.986 1.01 0.983 20901 208958 FALSE 0.00744648216786438 0.000159 0.00729 -0.00581 0.0206 0.778 0.994 0.955 1.04 0.0126 0.0205 0.54 1.01 0.973 1.05 0.00692 0.0206 0.738 1.01 0.967 1.05 ukb-melanoma-latest-gwas all 578.1 Hematemesis Digestive Both 1.01 0.966 1.06 0.609 1941 19396 FALSE 0.215382707367125 0.0122 0.0239 0.0223 0.0679 0.742 1.02 0.895 1.17 0.0478 0.0676 0.48 1.05 0.919 1.2 0.0518 0.0679 0.445 1.05 0.922 1.2 ukb-melanoma-latest-gwas all 578.2 Blood in stool Digestive Both 0.985 0.946 1.03 0.478 2597 25956 FALSE 0.320572103387881 -0.0147 0.0207 -0.0653 0.058 0.26 0.937 0.836 1.05 -0.0902 0.0583 0.122 0.914 0.815 1.02 -0.0294 0.0577 0.611 0.971 0.867 1.09 ukb-melanoma-latest-gwas all 578.8 Hemorrhage of rectum and anus Digestive Both 1.01 0.989 1.03 0.432 13031 130279 FALSE 0.364516253185088 0.00725 0.00923 -0.0101 0.0262 0.7 0.99 0.94 1.04 0.0327 0.026 0.208 1.03 0.982 1.09 0.0144 0.0262 0.581 1.01 0.964 1.07 ukb-melanoma-latest-gwas all 578.9 Hemorrhage of gastrointestinal tract Digestive Both 1 0.976 1.03 0.783 5292 52920 FALSE 0.106238237942057 0.00399 0.0145 0.0128 0.041 0.755 1.01 0.935 1.1 0.0256 0.0409 0.531 1.03 0.947 1.11 0.0136 0.0411 0.741 1.01 0.935 1.1 ukb-melanoma-latest-gwas all 579 Other symptoms involving abdomen and pelvis Digestive Both 1.04 0.985 1.09 0.167 1553 15530 FALSE 0.777283528852417 0.037 0.0268 -0.0715 0.0768 0.351 0.931 0.801 1.08 0.0346 0.0751 0.645 1.04 0.893 1.2 0.059 0.0751 0.432 1.06 0.916 1.23 ukb-melanoma-latest-gwas all 579.2 Splenomegaly Digestive Both 1.01 0.91 1.11 0.898 426 4260 FALSE 0.0467236633326956 0.00654 0.0511 0.13 0.14 0.354 1.14 0.864 1.5 -0.106 0.148 0.475 0.9 0.671 1.2 0.0341 0.145 0.814 1.03 0.777 1.38 ukb-melanoma-latest-gwas all 580 Nephritis; nephrosis; renal sclerosis Genitourinary Both 1.03 0.975 1.08 0.316 1556 15560 FALSE 0.500312917381596 0.0267 0.0267 -0.0109 0.0764 0.886 0.989 0.851 1.15 0.0885 0.0748 0.237 1.09 0.943 1.27 0.0282 0.0759 0.71 1.03 0.886 1.19 ukb-melanoma-latest-gwas all 580.1 Glomerulonephritis Genitourinary Both 1.02 0.958 1.09 0.537 1069 10690 FALSE 0.270025714300444 0.0198 0.0321 -0.0517 0.0922 0.575 0.95 0.792 1.14 0.109 0.0891 0.222 1.11 0.936 1.33 -0.035 0.0918 0.703 0.966 0.806 1.16 ukb-melanoma-latest-gwas all 580.2 Nephrotic syndrome without mention of glomerulonephritis Genitourinary Both 1.03 0.933 1.13 0.593 469 4690 FALSE 0.226945306635737 0.0259 0.0485 -0.0534 0.137 0.697 0.948 0.723 1.24 -0.0502 0.138 0.716 0.951 0.725 1.25 0.0577 0.135 0.669 1.06 0.813 1.38 ukb-melanoma-latest-gwas all 580.3 Nephritis and nephropathy without mention of glomerulonephritis Genitourinary Both 1.02 0.892 1.16 0.811 253 2530 FALSE 0.0909791457888439 0.0158 0.066 -0.109 0.188 0.563 0.897 0.618 1.3 0.0898 0.181 0.62 1.09 0.766 1.57 -0.0611 0.187 0.744 0.941 0.65 1.36 ukb-melanoma-latest-gwas all 580.11 Proliferative glomerulonephritis Genitourinary Both 0.907 0.716 1.14 0.408 79 790 FALSE 0.38933983691012 -0.0974 0.118 -0.441 0.342 0.197 0.643 0.318 1.26 0.14 0.297 0.638 1.15 0.64 2.08 -0.432 0.34 0.204 0.65 0.324 1.27 ukb-melanoma-latest-gwas all 580.12 Non-proliferative glomerulonephritis Genitourinary Both 0.897 0.751 1.07 0.225 136 1360 FALSE 0.647817481888638 -0.109 0.0897 -0.31 0.252 0.218 0.733 0.442 1.2 0.0224 0.234 0.923 1.02 0.644 1.63 -0.427 0.261 0.102 0.652 0.385 1.09 ukb-melanoma-latest-gwas all 580.14 Chronic glomerulonephritis, NOS Genitourinary Both 1.05 0.976 1.12 0.204 881 8810 FALSE 0.690369832574101 0.0449 0.0354 0.0548 0.102 0.591 1.06 0.865 1.29 0.161 0.0998 0.107 1.17 0.966 1.43 0.0647 0.102 0.525 1.07 0.874 1.3 ukb-melanoma-latest-gwas all 580.32 Nephritis and nephropathy with pathological lesion Genitourinary Both 1.02 0.892 1.16 0.811 253 2530 FALSE 0.0909791457888439 0.0158 0.066 -0.109 0.188 0.563 0.897 0.618 1.3 0.0898 0.181 0.62 1.09 0.766 1.57 -0.0611 0.187 0.744 0.941 0.65 1.36 ukb-melanoma-latest-gwas all 585 Renal failure Genitourinary Both 1 0.978 1.03 0.83 7013 70119 FALSE 0.0809219076239261 0.00269 0.0126 0.00168 0.0353 0.962 1 0.935 1.07 -0.0307 0.0356 0.388 0.97 0.904 1.04 -0.00858 0.0356 0.81 0.991 0.925 1.06 ukb-melanoma-latest-gwas all 585.1 Acute renal failure Genitourinary Both 0.995 0.965 1.03 0.756 4537 45366 FALSE 0.121478204498793 -0.00486 0.0156 -0.00523 0.0438 0.905 0.995 0.913 1.08 -0.0331 0.0441 0.453 0.967 0.887 1.05 -0.0295 0.0443 0.506 0.971 0.89 1.06 ukb-melanoma-latest-gwas all 585.2 Renal failure NOS Genitourinary Both 1.01 0.958 1.07 0.697 1466 14657 FALSE 0.156767221901991 0.0107 0.0275 -0.0243 0.0767 0.752 0.976 0.84 1.13 -0.0804 0.0777 0.301 0.923 0.792 1.07 -0.0543 0.0775 0.483 0.947 0.813 1.1 ukb-melanoma-latest-gwas all 585.3 Chronic renal failure [CKD] Genitourinary Both 0.996 0.957 1.04 0.852 2652 26514 FALSE 0.0695604052332999 -0.0038 0.0204 -0.00332 0.0577 0.954 0.997 0.89 1.12 -0.0131 0.0578 0.821 0.987 0.881 1.11 0.00335 0.0578 0.954 1 0.896 1.12 ukb-melanoma-latest-gwas all 585.31 Renal dialysis Genitourinary Both 1.03 0.935 1.13 0.592 494 4940 FALSE 0.22767829327708 0.0254 0.0474 -0.227 0.139 0.102 0.797 0.606 1.05 0.0871 0.129 0.5 1.09 0.847 1.41 -0.0361 0.133 0.786 0.965 0.743 1.25 ukb-melanoma-latest-gwas all 586 Other disorders of the kidney and ureters Genitourinary Both 1.01 0.979 1.05 0.443 3382 33819 FALSE 0.35359627377693 0.0139 0.0181 0.143 0.051 0.00522 1.15 1.04 1.27 0.0605 0.052 0.245 1.06 0.959 1.18 0.0611 0.0522 0.242 1.06 0.96 1.18 ukb-melanoma-latest-gwas all 586.1 Anatomical abnormatilies of kidney and ureters Genitourinary Both 1.05 0.914 1.21 0.477 215 2150 FALSE 0.321481620959886 0.0508 0.0715 0.0731 0.212 0.73 1.08 0.707 1.64 0.347 0.201 0.0847 1.42 0.953 2.12 0.174 0.208 0.402 1.19 0.79 1.8 ukb-melanoma-latest-gwas all 586.2 Cyst of kidney, acquired Genitourinary Both 1 0.945 1.06 0.944 1258 12579 FALSE 0.0250280057019311 0.00209 0.0297 0.112 0.0832 0.179 1.12 0.95 1.32 0.0388 0.0847 0.647 1.04 0.88 1.23 0.0201 0.0853 0.814 1.02 0.863 1.21 ukb-melanoma-latest-gwas all 586.3 Vascular disorders of kidney/hypertrophy Genitourinary Both 1.02 0.811 1.28 0.862 80 800 FALSE 0.0644927341752872 0.0201 0.116 -0.0252 0.337 0.94 0.975 0.494 1.92 0.0625 0.33 0.85 1.06 0.549 2.08 0.239 0.323 0.46 1.27 0.668 2.44 ukb-melanoma-latest-gwas all 586.4 Stricture/obstruction of ureter Genitourinary Both 1 0.937 1.07 0.935 916 9160 FALSE 0.0291883891274822 0.00285 0.0348 0.207 0.0966 0.0323 1.23 1.02 1.49 0.0587 0.0998 0.556 1.06 0.872 1.29 -0.00514 0.102 0.96 0.995 0.814 1.22 ukb-melanoma-latest-gwas all 586.11 Small kidney Genitourinary Both 1.05 0.897 1.22 0.561 180 1800 FALSE 0.251037138743839 0.0453 0.0779 -0.0506 0.233 0.828 0.951 0.597 1.51 0.347 0.215 0.107 1.41 0.927 2.18 0.109 0.225 0.629 1.11 0.715 1.74 ukb-melanoma-latest-gwas all 587 Kidney replaced by transpant Genitourinary Both 0.98 0.88 1.09 0.716 369 3690 FALSE 0.145086977692144 -0.0199 0.0546 -0.106 0.156 0.497 0.899 0.661 1.22 0.0662 0.151 0.66 1.07 0.794 1.44 -0.0271 0.155 0.861 0.973 0.717 1.32 ukb-melanoma-latest-gwas all 588 Disorders resulting from impaired renal function Genitourinary Both 0.976 0.792 1.2 0.814 99 990 FALSE 0.0893755951107988 -0.0247 0.105 -0.318 0.299 0.288 0.727 0.396 1.32 -0.132 0.284 0.643 0.876 0.496 1.54 -0.164 0.285 0.566 0.849 0.479 1.5 ukb-melanoma-latest-gwas all 589 Abnormal results of function study of kidney Genitourinary Both 1.02 0.845 1.24 0.805 117 1170 FALSE 0.0942041196321315 0.024 0.0971 0.584 0.277 0.0349 1.79 1.04 3.15 -0.136 0.314 0.665 0.873 0.463 1.64 0.544 0.285 0.0562 1.72 0.985 3.07 ukb-melanoma-latest-gwas all 590 Pyelonephritis Genitourinary Both 0.96 0.907 1.02 0.155 1331 13310 FALSE 0.809668301829709 -0.041 0.0288 -0.00194 0.0805 0.981 0.998 0.852 1.17 -0.0265 0.081 0.744 0.974 0.831 1.14 -0.0657 0.0819 0.422 0.936 0.797 1.1 ukb-melanoma-latest-gwas all 591 Urinary tract infection Genitourinary Both 1.01 0.988 1.03 0.465 12432 124264 FALSE 0.332547047110046 0.00691 0.00945 0.0283 0.0267 0.29 1.03 0.976 1.08 0.0252 0.0268 0.346 1.03 0.973 1.08 0.0307 0.0269 0.253 1.03 0.978 1.09 ukb-melanoma-latest-gwas all 592 Cystitis and urethritis Genitourinary Both 1.02 0.982 1.06 0.313 3076 30754 FALSE 0.504455662453552 0.0192 0.019 0.0202 0.0539 0.707 1.02 0.918 1.13 0.0307 0.0538 0.568 1.03 0.928 1.15 0.0424 0.0539 0.432 1.04 0.939 1.16 ukb-melanoma-latest-gwas all 592.1 Cystitis Genitourinary Both 1.02 0.984 1.06 0.253 2936 29354 FALSE 0.596879478824182 0.0222 0.0194 0.0259 0.0552 0.639 1.03 0.921 1.14 0.0302 0.0552 0.584 1.03 0.925 1.15 0.0502 0.0552 0.363 1.05 0.944 1.17 ukb-melanoma-latest-gwas all 592.2 Urethritis and urethral syndrome Genitourinary Both 0.955 0.814 1.12 0.567 167 1670 FALSE 0.246416941107093 -0.0462 0.0808 -0.00298 0.228 0.99 0.997 0.634 1.57 0.219 0.217 0.313 1.25 0.812 1.92 -0.25 0.242 0.302 0.779 0.48 1.26 ukb-melanoma-latest-gwas all 592.11 Acute cystitis Genitourinary Both 0.995 0.834 1.19 0.951 137 1370 FALSE 0.0218194830625861 -0.00546 0.0889 -0.599 0.264 0.0231 0.549 0.321 0.919 -0.449 0.252 0.0748 0.638 0.383 1.05 0.00993 0.225 0.965 1.01 0.647 1.58 ukb-melanoma-latest-gwas all 592.12 Chronic cystitis Genitourinary Both 1.05 0.98 1.13 0.163 889 8890 FALSE 0.787812395596042 0.0493 0.0353 0.0955 0.101 0.345 1.1 0.902 1.34 0.168 0.0998 0.0921 1.18 0.973 1.44 0.0778 0.102 0.446 1.08 0.885 1.32 ukb-melanoma-latest-gwas all 592.13 Chronic interstitial cystitis Genitourinary Both 1 0.878 1.14 0.987 247 2470 FALSE 0.00568284733036327 0.00111 0.0666 0.266 0.187 0.156 1.3 0.903 1.89 0.197 0.191 0.301 1.22 0.837 1.78 0.03 0.198 0.88 1.03 0.696 1.53 ukb-melanoma-latest-gwas all 593 Hematuria Genitourinary Both 1.02 1 1.03 0.0442 16202 161323 TRUE 1.35457773065091 0.0167 0.00828 0.0481 0.0236 0.0411 1.05 1 1.1 0.0687 0.0235 0.00344 1.07 1.02 1.12 0.0575 0.0236 0.015 1.06 1.01 1.11 ukb-melanoma-latest-gwas all 594 Urinary calculus Genitourinary Both 1.03 1 1.05 0.0481 6612 66119 TRUE 1.31785492362617 0.0256 0.013 0.0255 0.0369 0.49 1.03 0.954 1.1 0.0718 0.0366 0.05 1.07 1 1.15 0.0544 0.0369 0.14 1.06 0.982 1.14 ukb-melanoma-latest-gwas all 594.1 Calculus of kidney Genitourinary Both 1.02 0.985 1.06 0.242 3176 31760 FALSE 0.616184634019569 0.0218 0.0187 0.0592 0.0531 0.265 1.06 0.956 1.18 0.0694 0.053 0.191 1.07 0.966 1.19 0.0552 0.0533 0.3 1.06 0.952 1.17 ukb-melanoma-latest-gwas all 594.2 Calculus of lower urinary tract Genitourinary Both 1.06 0.981 1.14 0.149 776 7760 FALSE 0.826813731587726 0.0546 0.0378 -0.0494 0.108 0.648 0.952 0.77 1.18 -0.0194 0.107 0.856 0.981 0.794 1.21 0.0867 0.105 0.409 1.09 0.887 1.34 ukb-melanoma-latest-gwas all 594.3 Calculus of ureter Genitourinary Both 0.995 0.954 1.04 0.814 2403 24029 FALSE 0.0893755951107988 -0.00505 0.0215 -0.0192 0.061 0.753 0.981 0.87 1.11 0.0924 0.0596 0.121 1.1 0.976 1.23 -0.05 0.0617 0.418 0.951 0.843 1.07 ukb-melanoma-latest-gwas all 594.8 Renal colic Genitourinary Both 1.02 0.973 1.07 0.42 2045 20449 FALSE 0.3767507096021 0.0188 0.0233 -0.0116 0.0667 0.862 0.988 0.867 1.13 0.0848 0.0654 0.195 1.09 0.957 1.24 0.0383 0.0662 0.563 1.04 0.913 1.18 ukb-melanoma-latest-gwas all 595 Hydronephrosis Genitourinary Both 0.964 0.92 1.01 0.124 1953 19530 FALSE 0.906578314837765 -0.0366 0.0238 -0.0127 0.0666 0.849 0.987 0.867 1.13 -0.0183 0.0668 0.785 0.982 0.861 1.12 -0.0737 0.0677 0.277 0.929 0.813 1.06 ukb-melanoma-latest-gwas all 596 Other disorders of bladder Genitourinary Both 1.01 0.989 1.03 0.382 9856 98560 FALSE 0.417936637088291 0.00928 0.0106 0.0699 0.0299 0.0196 1.07 1.01 1.14 0.0342 0.0302 0.258 1.03 0.975 1.1 0.0361 0.0303 0.233 1.04 0.977 1.1 ukb-melanoma-latest-gwas all 596.1 Bladder neck obstruction Genitourinary Both 1.03 0.982 1.08 0.228 1963 19630 FALSE 0.642065152999546 0.0287 0.0238 0.0541 0.0678 0.424 1.06 0.924 1.21 0.0467 0.0679 0.492 1.05 0.917 1.2 0.102 0.0674 0.131 1.11 0.97 1.26 ukb-melanoma-latest-gwas all 596.5 Functional disorders of bladder Genitourinary Both 0.984 0.936 1.04 0.545 1653 16530 FALSE 0.263603497723358 -0.0157 0.0259 0.129 0.0722 0.0736 1.14 0.988 1.31 0.00398 0.0742 0.957 1 0.868 1.16 0.00883 0.0745 0.906 1.01 0.872 1.17 ukb-melanoma-latest-gwas all 597 Other disorders of urethra and urinary tract Genitourinary Both 1 0.971 1.04 0.863 3984 39834 FALSE 0.0639892042847904 0.00288 0.0167 -0.0282 0.0472 0.551 0.972 0.886 1.07 0.0139 0.0468 0.766 1.01 0.925 1.11 -0.0169 0.0474 0.722 0.983 0.896 1.08 ukb-melanoma-latest-gwas all 597.1 Urethral stricture (not specified as infectious) Genitourinary Both 1 0.966 1.04 0.964 3322 33214 FALSE 0.0159229660971692 0.000833 0.0183 -0.02 0.0516 0.697 0.98 0.886 1.08 0.000905 0.0514 0.986 1 0.905 1.11 -0.0141 0.0518 0.785 0.986 0.891 1.09 ukb-melanoma-latest-gwas all 598 Abnormal findings on examination of urine Genitourinary Both 1 0.97 1.04 0.812 3538 35378 FALSE 0.0904439707588247 0.00421 0.0177 -0.0414 0.0503 0.41 0.959 0.869 1.06 0.0206 0.0495 0.677 1.02 0.926 1.13 -0.00881 0.0501 0.861 0.991 0.898 1.09 ukb-melanoma-latest-gwas all 598.9 Other nonspecific findings on examination of urine Genitourinary Both 0.995 0.884 1.12 0.927 304 3040 FALSE 0.0329202658555029 -0.0055 0.0601 -0.425 0.178 0.0167 0.654 0.458 0.925 0.0258 0.159 0.871 1.03 0.75 1.4 -0.167 0.167 0.317 0.846 0.608 1.17 ukb-melanoma-latest-gwas all 599 Other symptoms/disorders or the urinary system Genitourinary Both 0.996 0.981 1.01 0.598 18729 187237 FALSE 0.223298816011589 -0.00406 0.0077 0.0282 0.0217 0.193 1.03 0.986 1.07 0.0169 0.0218 0.438 1.02 0.975 1.06 -0.00383 0.0219 0.861 0.996 0.954 1.04 ukb-melanoma-latest-gwas all 599.1 Urinary obstruction Genitourinary Both 0.926 0.79 1.09 0.344 167 1670 FALSE 0.46344155742847 -0.0764 0.0807 0.071 0.215 0.742 1.07 0.701 1.65 -0.147 0.228 0.517 0.863 0.548 1.35 -0.254 0.235 0.279 0.776 0.485 1.23 ukb-melanoma-latest-gwas all 599.2 Retention of urine Genitourinary Both 1.02 0.996 1.05 0.105 6733 67330 FALSE 0.978810700930062 0.0208 0.0128 0.0162 0.0366 0.659 1.02 0.946 1.09 0.0696 0.0362 0.0545 1.07 0.999 1.15 0.0466 0.0365 0.202 1.05 0.975 1.13 ukb-melanoma-latest-gwas all 599.3 Dysuria Genitourinary Both 1.02 0.965 1.09 0.423 1199 11990 FALSE 0.373659632624958 0.0244 0.0304 0.0983 0.0877 0.262 1.1 0.929 1.31 0.196 0.0863 0.0232 1.22 1.03 1.44 0.0897 0.0882 0.309 1.09 0.92 1.3 ukb-melanoma-latest-gwas all 599.4 Urinary incontinence Genitourinary Both 0.985 0.963 1.01 0.166 8766 87659 FALSE 0.779891911959945 -0.0156 0.0112 0.00922 0.0316 0.77 1.01 0.949 1.07 -0.00316 0.0317 0.921 0.997 0.937 1.06 -0.0335 0.032 0.296 0.967 0.908 1.03 ukb-melanoma-latest-gwas all 599.5 Frequency of urination and polyuria Genitourinary Both 1.01 0.975 1.04 0.685 4023 40230 FALSE 0.164309428507574 0.00674 0.0166 0.0142 0.0471 0.762 1.01 0.925 1.11 0.0622 0.0467 0.183 1.06 0.971 1.17 0.00805 0.0474 0.865 1.01 0.919 1.11 ukb-melanoma-latest-gwas all 599.6 Oliguria and anuria Genitourinary Both 0.934 0.765 1.14 0.496 107 1070 FALSE 0.304518323509803 -0.0682 0.1 -0.00484 0.278 0.986 0.995 0.571 1.73 0.0435 0.275 0.874 1.04 0.604 1.81 -0.157 0.288 0.587 0.855 0.478 1.52 ukb-melanoma-latest-gwas all 599.8 Other symptoms involving urinary system Genitourinary Both 1.01 0.81 1.26 0.929 87 870 FALSE 0.0319842860063582 0.00987 0.111 -0.00523 0.316 0.987 0.995 0.528 1.87 0.0972 0.309 0.753 1.1 0.595 2.05 0.092 0.313 0.769 1.1 0.587 2.05 ukb-melanoma-latest-gwas all 599.9 Other abnormality of urination Genitourinary Both 1 0.955 1.05 0.981 1921 19210 FALSE 0.0083309926200515 0.000557 0.024 0.0251 0.0673 0.709 1.03 0.899 1.17 -0.0295 0.0684 0.666 0.971 0.849 1.11 0.00359 0.0679 0.958 1 0.878 1.15 ukb-melanoma-latest-gwas all 600 Hyperplasia of prostate Genitourinary Male 1.03 1.01 1.05 0.0085 11123 87742 TRUE 2.07058107428571 0.0267 0.0102 0.0478 0.029 0.0996 1.05 0.991 1.11 0.0586 0.029 0.0431 1.06 1 1.12 0.0998 0.0288 0.000525 1.1 1.04 1.17 ukb-melanoma-latest-gwas all 601 Inflammatory diseases of prostate Genitourinary Male 0.998 0.955 1.04 0.936 2188 21880 FALSE 0.0287241512618947 -0.00181 0.0225 -0.0235 0.0637 0.712 0.977 0.862 1.11 0.0057 0.0633 0.928 1.01 0.888 1.14 0.00329 0.0636 0.959 1 0.886 1.14 ukb-melanoma-latest-gwas all 601.1 Prostatitis Genitourinary Male 1 0.954 1.06 0.853 1576 15760 FALSE 0.069050968832477 0.00492 0.0265 -0.0296 0.0754 0.695 0.971 0.837 1.13 -0.0058 0.0749 0.938 0.994 0.858 1.15 0.0452 0.0743 0.543 1.05 0.904 1.21 ukb-melanoma-latest-gwas all 601.3 Orchitis and epididymitis Genitourinary Male 0.946 0.722 1.24 0.682 59 590 FALSE 0.166215625343521 -0.0556 0.135 0.331 0.366 0.367 1.39 0.676 2.94 0.275 0.373 0.461 1.32 0.627 2.82 -0.43 0.435 0.323 0.651 0.262 1.56 ukb-melanoma-latest-gwas all 601.4 Balanoposthitis Genitourinary Male 1.01 0.893 1.14 0.878 286 2860 FALSE 0.0565054840938974 0.00949 0.0621 -0.0786 0.177 0.657 0.924 0.651 1.31 0.103 0.17 0.543 1.11 0.794 1.55 -0.0526 0.177 0.766 0.949 0.669 1.34 ukb-melanoma-latest-gwas all 601.8 Other inflammatory disorders of male genital organs Genitourinary Male 0.99 0.879 1.11 0.863 303 3030 FALSE 0.0639892042847904 -0.0104 0.0603 0.0713 0.168 0.671 1.07 0.771 1.5 -0.0515 0.173 0.766 0.95 0.675 1.33 0.0184 0.17 0.914 1.02 0.728 1.43 ukb-melanoma-latest-gwas all 601.11 Acute prostatitis Genitourinary Male 0.992 0.867 1.13 0.905 235 2350 FALSE 0.0433514207947967 -0.0081 0.0681 0.0138 0.19 0.942 1.01 0.696 1.48 -0.133 0.196 0.498 0.876 0.594 1.29 0.0351 0.189 0.853 1.04 0.714 1.5 ukb-melanoma-latest-gwas all 601.12 Chronic prostatitis Genitourinary Male 1.05 0.981 1.13 0.158 910 9100 FALSE 0.801342913045577 0.0493 0.0349 0.0136 0.1 0.892 1.01 0.832 1.23 0.0483 0.0996 0.627 1.05 0.863 1.28 0.145 0.0978 0.137 1.16 0.955 1.4 ukb-melanoma-latest-gwas all 602 Other disorders of prostate Genitourinary Male 1.03 0.971 1.09 0.355 1343 13430 FALSE 0.449771646944906 0.0266 0.0288 0.0799 0.0831 0.336 1.08 0.92 1.28 0.161 0.0817 0.0481 1.18 1 1.38 0.141 0.0826 0.0875 1.15 0.979 1.35 ukb-melanoma-latest-gwas all 603 Other disorders of testis Genitourinary Male 0.995 0.952 1.04 0.811 2192 21912 FALSE 0.0909791457888439 -0.00537 0.0225 -0.0354 0.0627 0.573 0.965 0.854 1.09 -0.0552 0.063 0.381 0.946 0.836 1.07 -0.0866 0.0637 0.174 0.917 0.809 1.04 ukb-melanoma-latest-gwas all 603.1 Hydrocele Genitourinary Male 0.979 0.926 1.04 0.469 1340 13400 FALSE 0.328827157284917 -0.0208 0.0287 -0.0605 0.0807 0.453 0.941 0.803 1.1 0.00898 0.0794 0.91 1.01 0.863 1.18 -0.129 0.0821 0.117 0.879 0.748 1.03 ukb-melanoma-latest-gwas all 604 Disorders of penis Genitourinary Male 1.01 0.974 1.05 0.623 3412 34093 FALSE 0.20551195334083 0.00887 0.0181 0.0381 0.051 0.455 1.04 0.94 1.15 0.0225 0.0512 0.661 1.02 0.925 1.13 0.0356 0.0513 0.488 1.04 0.937 1.15 ukb-melanoma-latest-gwas all 604.1 Redundant prepuce and phimosis/BXO Genitourinary Male 1.01 0.974 1.05 0.541 2853 28505 FALSE 0.266802734893431 0.0121 0.0197 0.0357 0.0559 0.523 1.04 0.929 1.16 0.0465 0.0558 0.404 1.05 0.939 1.17 0.0205 0.0563 0.716 1.02 0.914 1.14 ukb-melanoma-latest-gwas all 605 Erectile dysfunction [ED] Genitourinary Male 1.08 0.95 1.22 0.25 280 2800 FALSE 0.602059991327962 0.0728 0.0632 -0.191 0.183 0.297 0.826 0.574 1.18 -0.104 0.179 0.561 0.901 0.632 1.28 0.153 0.17 0.366 1.17 0.835 1.63 ukb-melanoma-latest-gwas all 608 Other disorders of male genital organs Genitourinary Male 1 0.966 1.04 0.812 2826 28259 FALSE 0.0904439707588247 0.00471 0.0198 0.00866 0.0562 0.878 1.01 0.903 1.13 0.0554 0.0557 0.32 1.06 0.948 1.18 0.0149 0.0565 0.792 1.02 0.909 1.13 ukb-melanoma-latest-gwas all 609 Male infertility and abnormal spermatozoa Genitourinary Male 1.02 0.893 1.17 0.744 233 2330 FALSE 0.128427064454121 0.0224 0.0688 0.0155 0.199 0.938 1.02 0.685 1.51 0.221 0.191 0.246 1.25 0.858 1.82 0.0747 0.198 0.706 1.08 0.729 1.6 ukb-melanoma-latest-gwas all 609.1 Infertility, male Genitourinary Male 0.848 0.655 1.1 0.205 64 640 FALSE 0.688246138944246 -0.165 0.13 0.0245 0.351 0.944 1.02 0.507 2.07 0.178 0.341 0.603 1.19 0.607 2.38 -0.523 0.404 0.196 0.593 0.255 1.32 ukb-melanoma-latest-gwas all 609.2 Abnormal spermatozoa Genitourinary Male 1.1 0.943 1.3 0.215 170 1700 FALSE 0.667561540084395 0.0998 0.0805 -0.00848 0.239 0.972 0.992 0.617 1.59 0.323 0.224 0.149 1.38 0.891 2.16 0.189 0.231 0.413 1.21 0.766 1.91 ukb-melanoma-latest-gwas all 610 Benign mammary dysplasias Genitourinary Female 1.07 1.03 1.11 0.00059 2838 28379 TRUE 3.22914798835786 0.068 0.0198 0.0537 0.0571 0.347 1.06 0.943 1.18 0.0787 0.0568 0.166 1.08 0.968 1.21 0.17 0.0559 0.00232 1.19 1.06 1.32 ukb-melanoma-latest-gwas all 610.1 Cystic mastopathy Genitourinary Female 1.09 1.02 1.17 0.00958 923 9229 TRUE 2.01863449092146 0.0899 0.0347 0.194 0.101 0.0534 1.21 0.997 1.48 0.0984 0.103 0.338 1.1 0.902 1.35 0.308 0.0987 0.00181 1.36 1.12 1.65 ukb-melanoma-latest-gwas all 610.2 Fibroadenosis of breast Genitourinary Female 1.18 1.04 1.33 0.00736 306 3060 TRUE 2.1331221856625 0.162 0.0606 -0.046 0.178 0.796 0.955 0.671 1.36 0.0798 0.174 0.646 1.08 0.769 1.53 0.329 0.167 0.0485 1.39 1 1.94 ukb-melanoma-latest-gwas all 610.3 Fibrosclerosis of breast Genitourinary Female 1.06 0.945 1.2 0.299 301 3010 FALSE 0.52432881167557 0.0628 0.0604 0.291 0.177 0.1 1.34 0.945 1.9 0.272 0.178 0.125 1.31 0.927 1.87 0.282 0.178 0.114 1.33 0.935 1.89 ukb-melanoma-latest-gwas all 610.4 Benign neoplasm of breast Genitourinary Female 1.05 0.993 1.1 0.0863 1548 15479 FALSE 1.06398920428479 0.0459 0.0268 -0.00471 0.0764 0.951 0.995 0.857 1.16 0.0375 0.0757 0.621 1.04 0.895 1.2 0.0659 0.0756 0.383 1.07 0.921 1.24 ukb-melanoma-latest-gwas all 610.8 Other specified benign mammary dysplasias Genitourinary Female 1.02 0.865 1.19 0.841 165 1650 FALSE 0.0752040042020878 0.0163 0.0815 -0.142 0.235 0.547 0.868 0.543 1.38 -0.0468 0.231 0.839 0.954 0.604 1.51 0.103 0.222 0.642 1.11 0.715 1.72 ukb-melanoma-latest-gwas all 611 Abnormal findings on mammogram or breast exam Genitourinary Both 1.04 0.99 1.1 0.11 1578 15780 FALSE 0.958607314841775 0.0424 0.0265 -0.0344 0.0749 0.647 0.966 0.834 1.12 -0.0825 0.0759 0.277 0.921 0.793 1.07 0.0698 0.0735 0.342 1.07 0.928 1.24 ukb-melanoma-latest-gwas all 611.1 Abnormal mammogram Genitourinary Both 1.19 0.909 1.57 0.196 57 570 FALSE 0.707743928643524 0.178 0.137 -0.309 0.382 0.418 0.734 0.335 1.56 -0.806 0.434 0.0636 0.447 0.175 1.04 0.171 0.342 0.616 1.19 0.604 2.36 ukb-melanoma-latest-gwas all 611.3 Lump or mass in breast Genitourinary Both 1.04 0.985 1.09 0.162 1523 15230 FALSE 0.790484985457369 0.0377 0.027 -0.0247 0.0764 0.747 0.976 0.84 1.13 -0.0496 0.077 0.519 0.952 0.818 1.11 0.0639 0.0752 0.395 1.07 0.92 1.24 ukb-melanoma-latest-gwas all 612 Breast conditions, congenital or relating to hormones Genitourinary Both 0.978 0.914 1.05 0.514 939 9390 FALSE 0.289036881004724 -0.0224 0.0343 0.126 0.0957 0.189 1.13 0.94 1.37 0.0343 0.0978 0.726 1.03 0.854 1.25 0.000521 0.099 0.996 1 0.824 1.22 ukb-melanoma-latest-gwas all 612.2 Hypertrophy of breast (Gynecomastia) Genitourinary Both 0.99 0.922 1.06 0.772 851 8510 FALSE 0.112382699664264 -0.0104 0.036 0.138 0.101 0.171 1.15 0.942 1.4 0.00969 0.104 0.926 1.01 0.824 1.24 0.05 0.103 0.628 1.05 0.858 1.29 ukb-melanoma-latest-gwas all 612.3 Congenital anomalies of breast Genitourinary Both 0.901 0.713 1.14 0.379 78 780 FALSE 0.421360790031928 -0.104 0.118 0.0861 0.32 0.788 1.09 0.577 2.07 0.133 0.318 0.677 1.14 0.606 2.17 -0.383 0.362 0.291 0.682 0.323 1.4 ukb-melanoma-latest-gwas all 613 Other nonmalignant breast conditions Genitourinary Both 1.07 1.02 1.12 0.00448 1981 19796 TRUE 2.34872198600186 0.0674 0.0237 0.135 0.0673 0.0454 1.14 1 1.31 0.0157 0.0691 0.82 1.02 0.887 1.16 0.181 0.0671 0.00703 1.2 1.05 1.37 ukb-melanoma-latest-gwas all 613.1 Inflammatory disease of breast Genitourinary Both 1.06 0.985 1.15 0.115 721 7205 FALSE 0.939302159646388 0.062 0.0393 0.239 0.111 0.0323 1.27 1.02 1.58 0.0625 0.116 0.589 1.06 0.848 1.34 0.226 0.113 0.0451 1.25 1 1.57 ukb-melanoma-latest-gwas all 613.5 Mastodynia Genitourinary Both 1.11 0.878 1.41 0.37 77 770 FALSE 0.431798275933005 0.106 0.119 0.216 0.351 0.539 1.24 0.615 2.54 0.313 0.346 0.365 1.37 0.691 2.76 0.485 0.345 0.159 1.62 0.824 3.28 ukb-melanoma-latest-gwas all 613.7 Other signs and symptoms in breast Genitourinary Both 1.09 1.01 1.18 0.0329 704 7031 TRUE 1.48280410205003 0.0847 0.0397 -0.0066 0.115 0.954 0.993 0.792 1.25 0.0966 0.113 0.392 1.1 0.883 1.38 0.168 0.111 0.131 1.18 0.951 1.47 ukb-melanoma-latest-gwas all 613.8 Other specified disorders of breast Genitourinary Both 1.07 0.953 1.2 0.256 328 3280 FALSE 0.59176003468815 0.066 0.0582 0.219 0.162 0.175 1.25 0.906 1.72 -0.0789 0.173 0.649 0.924 0.656 1.3 0.192 0.164 0.241 1.21 0.878 1.68 ukb-melanoma-latest-gwas all 613.9 Breast disorder NOS Genitourinary Both 1.01 0.874 1.17 0.899 207 2070 FALSE 0.0462403082667712 0.00929 0.0729 -0.151 0.199 0.448 0.86 0.579 1.27 -0.305 0.208 0.143 0.737 0.486 1.11 -0.0974 0.198 0.623 0.907 0.613 1.34 ukb-melanoma-latest-gwas all 614 Inflammatory diseases of female pelvic organs Genitourinary Female 1.01 0.987 1.04 0.328 6180 61800 FALSE 0.484126156288321 0.0131 0.0134 0.0482 0.0378 0.203 1.05 0.974 1.13 0.0079 0.0382 0.836 1.01 0.935 1.09 0.041 0.0381 0.281 1.04 0.967 1.12 ukb-melanoma-latest-gwas all 614.1 Pelvic peritoneal adhesions, female (postoperative) (postinfection) Genitourinary Female 1.03 0.989 1.07 0.156 2538 25380 FALSE 0.806875401645538 0.0297 0.0209 0.0345 0.0591 0.559 1.04 0.922 1.16 -0.0295 0.06 0.623 0.971 0.863 1.09 0.0676 0.0588 0.25 1.07 0.953 1.2 ukb-melanoma-latest-gwas all 614.3 Pelvic inflammatory disease (PID) Genitourinary Female 0.994 0.929 1.06 0.856 934 9340 FALSE 0.0675262353228468 -0.00627 0.0344 0.037 0.0975 0.704 1.04 0.857 1.26 0.0529 0.0971 0.586 1.05 0.871 1.28 0.0308 0.0983 0.754 1.03 0.85 1.25 ukb-melanoma-latest-gwas all 614.4 Inflammatory diseases of uterus, except cervix Genitourinary Female 0.981 0.867 1.11 0.761 278 2780 FALSE 0.118615343229427 -0.0192 0.063 0.0851 0.172 0.622 1.09 0.775 1.53 -0.141 0.181 0.436 0.868 0.606 1.24 -0.0153 0.178 0.931 0.985 0.693 1.4 ukb-melanoma-latest-gwas all 614.5 Inflammatory disease of cervix, vagina, and vulva Genitourinary Female 1.01 0.973 1.05 0.582 2850 28500 FALSE 0.235077015350112 0.0109 0.0198 0.0412 0.0557 0.459 1.04 0.934 1.16 -0.00809 0.0563 0.886 0.992 0.888 1.11 0.0416 0.0559 0.457 1.04 0.934 1.16 ukb-melanoma-latest-gwas all 614.31 Acute inflammatory pelvic disease Genitourinary Female 0.913 0.701 1.19 0.492 61 610 FALSE 0.30803489723264 -0.0909 0.132 -0.444 0.387 0.251 0.641 0.288 1.37 -0.203 0.36 0.573 0.816 0.394 1.67 -0.0387 0.348 0.912 0.962 0.477 1.93 ukb-melanoma-latest-gwas all 614.32 Chronic inflammatory pelvic disease Genitourinary Female 0.973 0.88 1.08 0.596 422 4220 FALSE 0.224753740259764 -0.0271 0.0511 -0.0546 0.14 0.697 0.947 0.719 1.25 -0.173 0.144 0.229 0.841 0.633 1.12 -0.14 0.144 0.329 0.869 0.655 1.15 ukb-melanoma-latest-gwas all 614.33 Pelvic inflammatory disease, NOS Genitourinary Female 0.969 0.868 1.08 0.569 352 3520 FALSE 0.244887733604929 -0.0319 0.0559 0.161 0.159 0.312 1.17 0.859 1.61 0.203 0.158 0.198 1.23 0.899 1.68 0.0534 0.164 0.745 1.05 0.763 1.46 ukb-melanoma-latest-gwas all 614.51 Cervicitis and endocervicitis Genitourinary Female 1.07 1.01 1.13 0.0286 1317 13170 TRUE 1.54363396687096 0.0638 0.0291 0.112 0.0838 0.18 1.12 0.949 1.32 0.0564 0.0849 0.506 1.06 0.896 1.25 0.228 0.0822 0.00562 1.26 1.07 1.48 ukb-melanoma-latest-gwas all 614.52 Vaginitis and vulvovaginitis Genitourinary Female 0.908 0.822 1 0.0575 426 4260 FALSE 1.24033215531037 -0.0965 0.0508 -0.101 0.137 0.46 0.904 0.689 1.18 -0.187 0.14 0.182 0.83 0.63 1.09 -0.347 0.146 0.0176 0.707 0.529 0.941 ukb-melanoma-latest-gwas all 614.53 Cyst or abscess of Bartholin's gland Genitourinary Female 1.01 0.935 1.09 0.828 754 7540 FALSE 0.0819696632151199 0.00836 0.0384 0.0143 0.109 0.896 1.01 0.819 1.26 0.0787 0.108 0.466 1.08 0.875 1.34 0.0398 0.11 0.717 1.04 0.839 1.29 ukb-melanoma-latest-gwas all 614.54 Abscess or ulceration of vulva Genitourinary Female 0.876 0.774 0.992 0.0357 274 2740 TRUE 1.44733178388781 -0.132 0.063 -0.0376 0.169 0.824 0.963 0.69 1.34 -0.184 0.175 0.291 0.832 0.588 1.17 -0.372 0.183 0.0419 0.69 0.479 0.986 ukb-melanoma-latest-gwas all 615 Endometriosis Genitourinary Female 1.04 1 1.07 0.0334 4035 40341 TRUE 1.47625353318844 0.0353 0.0166 0.0464 0.0477 0.331 1.05 0.954 1.15 0.115 0.0471 0.0147 1.12 1.02 1.23 0.0935 0.0475 0.0488 1.1 1 1.21 ukb-melanoma-latest-gwas all 617 Disorders secondary to childbirth, surgery, trauma Genitourinary Female 1.1 0.978 1.24 0.109 305 3050 FALSE 0.962573502059376 0.0965 0.0602 0.25 0.179 0.161 1.28 0.904 1.83 0.392 0.174 0.0243 1.48 1.05 2.09 0.282 0.178 0.112 1.33 0.936 1.89 ukb-melanoma-latest-gwas all 618 Genital prolapse Genitourinary Female 0.997 0.979 1.02 0.782 11829 118039 FALSE 0.106793246940152 -0.00268 0.00968 0.0221 0.0273 0.417 1.02 0.969 1.08 0.0147 0.0274 0.592 1.01 0.962 1.07 -0.000271 0.0275 0.992 1 0.947 1.06 ukb-melanoma-latest-gwas all 618.1 Prolapse of vaginal walls Genitourinary Female 1 0.979 1.03 0.805 7403 74030 FALSE 0.0942041196321315 0.00302 0.0122 0.0505 0.0346 0.144 1.05 0.983 1.13 0.0446 0.0347 0.199 1.05 0.977 1.12 0.0202 0.035 0.563 1.02 0.953 1.09 ukb-melanoma-latest-gwas all 618.2 Uterine/Uterovaginal prolapse Genitourinary Female 0.985 0.957 1.01 0.276 5397 53970 FALSE 0.559090917934782 -0.0156 0.0143 -0.000158 0.0401 0.997 1 0.924 1.08 -0.0454 0.0405 0.263 0.956 0.883 1.03 -0.0342 0.0405 0.399 0.966 0.893 1.05 ukb-melanoma-latest-gwas all 618.5 Prolapse of vaginal vault after hysterectomy Genitourinary Female 0.954 0.871 1.05 0.313 513 5130 FALSE 0.504455662453552 -0.0468 0.0464 0.0992 0.129 0.442 1.1 0.857 1.42 0.0709 0.129 0.584 1.07 0.832 1.39 -0.101 0.136 0.459 0.904 0.692 1.18 ukb-melanoma-latest-gwas all 618.6 Vaginal enterocele, congenital or acquired Genitourinary Female 1.03 0.952 1.12 0.456 680 6800 FALSE 0.341035157335565 0.0301 0.0404 -0.0224 0.115 0.846 0.978 0.779 1.23 -0.0102 0.115 0.929 0.99 0.79 1.24 0.0996 0.112 0.375 1.1 0.886 1.38 ukb-melanoma-latest-gwas all 619 Noninflammatory female genital disorders Genitourinary Female 0.995 0.974 1.02 0.634 9258 92573 FALSE 0.197910742118267 -0.00522 0.0109 -0.0571 0.0309 0.0643 0.944 0.889 1 -0.0342 0.0308 0.267 0.966 0.91 1.03 -0.0248 0.0308 0.421 0.976 0.918 1.04 ukb-melanoma-latest-gwas all 619.1 Noninflammatory disorders of ovary, fallopian tube, and broad ligament Genitourinary Female 0.945 0.875 1.02 0.149 722 7220 FALSE 0.826813731587726 -0.0565 0.0391 -0.156 0.109 0.155 0.856 0.69 1.06 -0.0414 0.107 0.698 0.959 0.778 1.18 -0.199 0.111 0.0741 0.82 0.658 1.02 ukb-melanoma-latest-gwas all 619.2 Disorders of uterus, NEC Genitourinary Female 1.02 0.985 1.06 0.256 3312 33120 FALSE 0.59176003468815 0.0208 0.0183 -0.0887 0.0521 0.0885 0.915 0.826 1.01 -0.0513 0.0517 0.32 0.95 0.858 1.05 0.0302 0.0509 0.553 1.03 0.933 1.14 ukb-melanoma-latest-gwas all 619.3 Noninflammatory disorders of cervix Genitourinary Female 0.995 0.957 1.03 0.794 2852 28513 FALSE 0.100179497572904 -0.00514 0.0197 -0.0447 0.0555 0.421 0.956 0.858 1.07 -0.0345 0.0555 0.534 0.966 0.866 1.08 -0.0278 0.0555 0.616 0.973 0.872 1.08 ukb-melanoma-latest-gwas all 619.4 Noninflammatory disorders of vagina Genitourinary Female 0.968 0.922 1.02 0.197 1764 17640 FALSE 0.705533773838407 -0.0323 0.025 -0.033 0.0698 0.636 0.968 0.844 1.11 -0.0483 0.0701 0.491 0.953 0.83 1.09 -0.0943 0.071 0.184 0.91 0.792 1.05 ukb-melanoma-latest-gwas all 619.5 Noninflammatory disorders of vulva and perineum Genitourinary Female 0.996 0.941 1.05 0.883 1342 13420 FALSE 0.0540392964224314 -0.00421 0.0287 -0.0267 0.0813 0.743 0.974 0.83 1.14 0.000986 0.0808 0.99 1 0.854 1.17 0.00025 0.0811 0.998 1 0.853 1.17 ukb-melanoma-latest-gwas all 620 Dysplasia of female genital organs Genitourinary Female 1.02 0.798 1.3 0.892 72 720 FALSE 0.0496351456238769 0.0166 0.122 -0.0786 0.358 0.826 0.924 0.448 1.89 0.247 0.332 0.457 1.28 0.663 2.51 0.0657 0.347 0.85 1.07 0.533 2.15 ukb-melanoma-latest-gwas all 621 Endometrial hyperplasia Genitourinary Female 1.04 0.977 1.1 0.221 1132 11320 FALSE 0.655607726314889 0.0383 0.0313 0.159 0.0903 0.0781 1.17 0.982 1.4 0.217 0.0892 0.0148 1.24 1.04 1.48 0.107 0.0916 0.244 1.11 0.93 1.33 ukb-melanoma-latest-gwas all 622 Polyp of female genital organs Genitourinary Female 1.01 0.995 1.04 0.147 10804 108040 FALSE 0.832682665251824 0.0147 0.0101 0.0297 0.0286 0.3 1.03 0.974 1.09 -0.00928 0.0289 0.748 0.991 0.936 1.05 0.0398 0.0287 0.165 1.04 0.984 1.1 ukb-melanoma-latest-gwas all 622.1 Polyp of corpus uteri Genitourinary Female 1.01 0.99 1.04 0.26 7854 78540 FALSE 0.585026652029182 0.0134 0.0119 0.00201 0.0337 0.952 1 0.938 1.07 0.0057 0.0337 0.866 1.01 0.941 1.07 0.0278 0.0336 0.407 1.03 0.963 1.1 ukb-melanoma-latest-gwas all 622.2 Mucous polyp of cervix Genitourinary Female 1.03 0.992 1.06 0.127 3422 34220 FALSE 0.896196279044043 0.0275 0.018 0.0149 0.0509 0.77 1.01 0.919 1.12 -0.0425 0.0516 0.41 0.958 0.866 1.06 0.0593 0.0506 0.241 1.06 0.961 1.17 ukb-melanoma-latest-gwas all 623 Hypertrophy of female genital organs Genitourinary Female 1.05 0.994 1.12 0.0805 1270 12700 FALSE 1.09420411963213 0.0517 0.0296 0.0206 0.0847 0.808 1.02 0.864 1.21 0.0485 0.0843 0.566 1.05 0.89 1.24 0.115 0.0834 0.168 1.12 0.953 1.32 ukb-melanoma-latest-gwas all 624 Symptoms involving female genital tract Genitourinary Female 0.984 0.916 1.06 0.671 810 8095 FALSE 0.173277479831008 -0.0157 0.0369 -0.078 0.105 0.458 0.925 0.752 1.14 0.00478 0.103 0.963 1 0.821 1.23 -0.0066 0.104 0.949 0.993 0.81 1.22 ukb-melanoma-latest-gwas all 624.1 Dystrophy of female genital tract Genitourinary Female 0.936 0.819 1.07 0.329 237 2370 FALSE 0.482804102050026 -0.0661 0.0677 -0.21 0.19 0.27 0.811 0.556 1.18 -0.0863 0.184 0.639 0.917 0.638 1.32 -0.218 0.191 0.254 0.804 0.551 1.17 ukb-melanoma-latest-gwas all 624.2 Atrophy of female genital tract Genitourinary Female 1 0.909 1.11 0.953 441 4410 FALSE 0.0209070993616736 0.00296 0.05 0.0542 0.144 0.706 1.06 0.796 1.4 0.118 0.142 0.407 1.12 0.851 1.49 0.105 0.143 0.463 1.11 0.839 1.47 ukb-melanoma-latest-gwas all 625 Pain and other symptoms associated with female genital organs Genitourinary Female 1.03 0.996 1.07 0.083 2996 29960 FALSE 1.08092190762393 0.0334 0.0193 0.00641 0.0544 0.906 1.01 0.905 1.12 -0.0726 0.0554 0.191 0.93 0.834 1.04 0.0812 0.0537 0.13 1.08 0.976 1.21 ukb-melanoma-latest-gwas all 625.1 Dyspareunia Genitourinary Female 1.05 0.991 1.12 0.0932 1188 11880 FALSE 1.03058408764602 0.0513 0.0306 0.0246 0.0873 0.778 1.02 0.863 1.22 -0.0141 0.0882 0.873 0.986 0.829 1.17 0.15 0.0854 0.0799 1.16 0.982 1.37 ukb-melanoma-latest-gwas all 626 Disorders of menstruation and other abnormal bleeding from female genital tract Genitourinary Female 1.02 1 1.04 0.0144 18324 129160 TRUE 1.84163750790475 0.0196 0.00799 0.0707 0.0226 0.0018 1.07 1.03 1.12 0.0371 0.0228 0.104 1.04 0.992 1.09 0.0585 0.0228 0.0101 1.06 1.01 1.11 ukb-melanoma-latest-gwas all 626.1 Irregular menstrual cycle/bleeding Genitourinary Female 1.01 0.995 1.03 0.157 15686 122281 FALSE 0.804100347590766 0.0121 0.00855 0.0668 0.0242 0.00571 1.07 1.02 1.12 0.0265 0.0244 0.277 1.03 0.979 1.08 0.0415 0.0244 0.0889 1.04 0.994 1.09 ukb-melanoma-latest-gwas all 626.2 Dysmenorrhea Genitourinary Female 1.02 0.968 1.07 0.517 1781 17801 FALSE 0.286509456906058 0.0162 0.025 -0.0705 0.0716 0.325 0.932 0.81 1.07 0.044 0.0698 0.528 1.05 0.911 1.2 0.0353 0.0703 0.616 1.04 0.903 1.19 ukb-melanoma-latest-gwas all 626.4 Premenstrual tension syndromes Genitourinary Female 0.963 0.818 1.13 0.646 159 1588 FALSE 0.189767482004916 -0.0381 0.0828 0.205 0.235 0.384 1.23 0.772 1.96 0.169 0.237 0.475 1.18 0.742 1.9 0.0923 0.241 0.701 1.1 0.681 1.77 ukb-melanoma-latest-gwas all 626.8 Infertility, female Genitourinary Female 1.09 1.03 1.16 0.00166 1366 13624 TRUE 2.77989191195995 0.0897 0.0285 0.284 0.0825 0.000581 1.33 1.13 1.56 0.206 0.0839 0.0141 1.23 1.04 1.45 0.252 0.0834 0.00256 1.29 1.09 1.52 ukb-melanoma-latest-gwas all 626.11 Absent or infrequent menstruation Genitourinary Female 0.958 0.807 1.14 0.625 144 1440 FALSE 0.204119982655925 -0.0425 0.087 -0.0412 0.234 0.86 0.96 0.603 1.53 -0.517 0.264 0.0504 0.596 0.349 1 0.031 0.233 0.894 1.03 0.65 1.64 ukb-melanoma-latest-gwas all 626.12 Excessive or frequent menstruation Genitourinary Female 1.01 0.989 1.03 0.375 9734 91841 FALSE 0.425968732272281 0.0095 0.0107 0.0597 0.0302 0.0481 1.06 1 1.13 0.0328 0.0304 0.28 1.03 0.974 1.1 0.0171 0.0306 0.577 1.02 0.958 1.08 ukb-melanoma-latest-gwas all 626.13 Irregular menstrual cycle Genitourinary Female 1.03 0.981 1.08 0.26 1985 19849 FALSE 0.585026652029182 0.0267 0.0236 0.0128 0.0676 0.85 1.01 0.887 1.16 0.0443 0.0672 0.509 1.05 0.916 1.19 0.0939 0.0667 0.159 1.1 0.964 1.25 ukb-melanoma-latest-gwas all 626.14 Irregular menstrual bleeding Genitourinary Female 1.02 0.983 1.05 0.338 3809 38080 FALSE 0.471083299722345 0.0163 0.0171 0.0864 0.0481 0.0724 1.09 0.992 1.2 0.0189 0.0488 0.699 1.02 0.926 1.12 0.0498 0.0486 0.306 1.05 0.956 1.16 ukb-melanoma-latest-gwas all 627 Menopausal and postmenopausal disorders Genitourinary Female 1 0.983 1.02 0.784 10631 106298 FALSE 0.105683937315562 0.00281 0.0102 0.00709 0.0289 0.806 1.01 0.952 1.07 -0.00449 0.029 0.877 0.996 0.941 1.05 0.0203 0.0289 0.483 1.02 0.964 1.08 ukb-melanoma-latest-gwas all 627.1 Postmenopausal bleeding Genitourinary Female 1 0.983 1.03 0.69 9055 90540 FALSE 0.161150909262745 0.00442 0.0111 -0.00745 0.0313 0.812 0.993 0.934 1.06 -0.0181 0.0314 0.565 0.982 0.923 1.04 0.0274 0.0312 0.38 1.03 0.967 1.09 ukb-melanoma-latest-gwas all 627.2 Symptomatic menopause Genitourinary Female 0.957 0.823 1.11 0.569 184 1839 FALSE 0.244887733604929 -0.0438 0.0768 -0.0722 0.216 0.739 0.93 0.606 1.43 -0.162 0.222 0.465 0.85 0.547 1.32 0.0411 0.21 0.845 1.04 0.688 1.58 ukb-melanoma-latest-gwas all 627.3 Postmenopausal atrophic vaginitis Genitourinary Female 1.01 0.946 1.07 0.836 1114 11140 FALSE 0.0777937225609836 0.00653 0.0316 0.0893 0.0887 0.314 1.09 0.919 1.3 0.047 0.0896 0.6 1.05 0.879 1.25 0.00427 0.0906 0.962 1 0.841 1.2 ukb-melanoma-latest-gwas all 627.4 Premenopausal menorrhagia Genitourinary Female 0.958 0.852 1.08 0.473 311 3110 FALSE 0.325138859262188 -0.0427 0.0595 0.233 0.166 0.16 1.26 0.912 1.75 0.208 0.167 0.212 1.23 0.887 1.71 -0.127 0.18 0.483 0.881 0.617 1.26 ukb-melanoma-latest-gwas all 628 Ovarian cyst Genitourinary Female 1.02 0.988 1.05 0.235 4755 47550 FALSE 0.628932137728264 0.0181 0.0153 0.102 0.0431 0.0186 1.11 1.02 1.2 0.07 0.0435 0.108 1.07 0.985 1.17 0.038 0.0439 0.386 1.04 0.953 1.13 ukb-melanoma-latest-gwas all 634 Miscarriage; stillbirth Pregnancy Complications Female 1.01 0.985 1.04 0.361 5450 38533 FALSE 0.442492798094342 0.0134 0.0146 -0.00424 0.0414 0.918 0.996 0.918 1.08 -0.0364 0.0417 0.383 0.964 0.889 1.05 0.0477 0.0411 0.245 1.05 0.968 1.14 ukb-melanoma-latest-gwas all 634.1 Missed abortion/Hydatidiform mole Pregnancy Complications Female 1.05 0.992 1.12 0.0894 1251 12453 FALSE 1.04866248120408 0.0505 0.0298 -0.0553 0.0853 0.517 0.946 0.8 1.12 -0.0536 0.0854 0.53 0.948 0.801 1.12 0.129 0.0821 0.116 1.14 0.969 1.34 ukb-melanoma-latest-gwas all 634.3 Ectopic pregnancy Pregnancy Complications Female 1.05 0.94 1.18 0.365 331 3307 FALSE 0.437707135543525 0.0523 0.0578 0.0706 0.163 0.664 1.07 0.779 1.48 -0.0581 0.169 0.731 0.944 0.675 1.32 0.177 0.162 0.274 1.19 0.869 1.64 ukb-melanoma-latest-gwas all 635 Hemorrhage during pregnancy; childbirth and postpartum Pregnancy Complications Female 1 0.954 1.05 0.987 2003 17602 FALSE 0.00568284733036327 -0.000387 0.0237 -0.023 0.0672 0.732 0.977 0.856 1.12 0.00657 0.0669 0.922 1.01 0.883 1.15 0.0263 0.0669 0.694 1.03 0.9 1.17 ukb-melanoma-latest-gwas all 635.2 Antepartum hemorrhage, abruptio placentae, and placenta previa Pregnancy Complications Female 0.966 0.9 1.04 0.326 866 8626 FALSE 0.486782399932061 -0.0351 0.0357 0.0237 0.0995 0.812 1.02 0.842 1.25 -0.000699 0.1 0.994 0.999 0.821 1.22 -0.0667 0.102 0.514 0.935 0.765 1.14 ukb-melanoma-latest-gwas all 635.3 Placenta previa and abruptio placenta Pregnancy Complications Female 1.03 0.972 1.09 0.314 1273 12329 FALSE 0.503070351926785 0.0298 0.0296 -0.0328 0.0847 0.699 0.968 0.819 1.14 0.0208 0.0838 0.804 1.02 0.866 1.2 0.0898 0.0829 0.279 1.09 0.93 1.29 ukb-melanoma-latest-gwas all 636 Early or threatened labor; hemorrhage in early pregnancy Pregnancy Complications Female 1 0.962 1.04 0.923 2553 22013 FALSE 0.0347982989740879 0.00202 0.021 -0.00155 0.0593 0.979 0.998 0.889 1.12 0.00266 0.0593 0.964 1 0.893 1.13 -0.00316 0.0596 0.958 0.997 0.887 1.12 ukb-melanoma-latest-gwas all 636.2 Early onset of delivery Pregnancy Complications Female 1.01 0.927 1.09 0.865 617 6155 FALSE 0.0629838925351858 0.0072 0.0424 -0.0192 0.118 0.871 0.981 0.778 1.24 -0.0683 0.119 0.568 0.934 0.738 1.18 -0.0605 0.119 0.613 0.941 0.744 1.19 ukb-melanoma-latest-gwas all 636.3 Hemorrhage in early pregnancy Pregnancy Complications Female 0.988 0.928 1.05 0.699 1082 10774 FALSE 0.155522824254319 -0.0124 0.032 -0.0138 0.0904 0.879 0.986 0.826 1.18 0.018 0.0897 0.841 1.02 0.854 1.21 -0.0456 0.0911 0.617 0.955 0.799 1.14 ukb-melanoma-latest-gwas all 638 Other high-risk pregnancy Pregnancy Complications Female 1.01 0.791 1.29 0.917 70 700 FALSE 0.0376306643299789 0.0128 0.123 -0.0141 0.357 0.968 0.986 0.48 2.03 0.0371 0.351 0.916 1.04 0.513 2.11 0.266 0.339 0.434 1.3 0.666 2.6 ukb-melanoma-latest-gwas all 642 Hypertension complicating pregnancy, childbirth, and the puerperium Pregnancy Complications Female 1.03 0.972 1.1 0.285 1112 11107 FALSE 0.54515513999149 0.0338 0.0316 0.00301 0.0896 0.973 1 0.841 1.2 -0.0305 0.0904 0.736 0.97 0.812 1.16 0.102 0.0881 0.245 1.11 0.932 1.32 ukb-melanoma-latest-gwas all 642.1 Preeclampsia and eclampsia Pregnancy Complications Female 1.07 0.947 1.2 0.291 307 3063 FALSE 0.536107011014093 0.0634 0.06 0.118 0.169 0.487 1.12 0.806 1.57 0.0418 0.172 0.809 1.04 0.742 1.47 0.111 0.17 0.513 1.12 0.8 1.56 ukb-melanoma-latest-gwas all 643 Excessive vomiting in pregnancy Pregnancy Complications Female 1.09 0.953 1.25 0.201 230 2299 FALSE 0.696803942579511 0.0884 0.0692 -0.0872 0.204 0.669 0.916 0.611 1.37 0.0341 0.198 0.863 1.03 0.7 1.53 0.277 0.19 0.146 1.32 0.908 1.93 ukb-melanoma-latest-gwas all 643.1 Hyperemesis gravidarum Pregnancy Complications Female 1.01 0.855 1.19 0.906 153 1529 FALSE 0.0428718023231869 0.01 0.0847 -0.0768 0.243 0.752 0.926 0.57 1.5 0.036 0.236 0.879 1.04 0.649 1.66 0.115 0.236 0.625 1.12 0.704 1.79 ukb-melanoma-latest-gwas all 645 Late pregnancy and failed induction Pregnancy Complications Female 1.04 0.977 1.1 0.235 1253 12474 FALSE 0.628932137728264 0.0353 0.0298 0.000161 0.0848 0.998 1 0.847 1.18 0.0427 0.084 0.611 1.04 0.885 1.23 0.0397 0.0843 0.638 1.04 0.882 1.23 ukb-melanoma-latest-gwas all 646 Other complications of pregnancy NEC Pregnancy Complications Female 1.01 0.964 1.05 0.76 2230 20875 FALSE 0.119186407719209 0.00683 0.0224 -0.088 0.064 0.169 0.916 0.808 1.04 -0.0266 0.063 0.672 0.974 0.86 1.1 0.0378 0.0622 0.544 1.04 0.919 1.17 ukb-melanoma-latest-gwas all 647 Infectious and parasitic complications affecting pregnancy Pregnancy Complications Female 0.732 0.565 0.944 0.0158 68 680 TRUE 1.80134291304558 -0.311 0.129 0.0528 0.318 0.868 1.05 0.562 1.99 -0.326 0.354 0.357 0.722 0.35 1.45 -0.821 0.393 0.0367 0.44 0.191 0.944 ukb-melanoma-latest-gwas all 649 Other conditions or status of the mother complicating pregnancy, childbirth, or the puerperium Pregnancy Complications Female 0.931 0.767 1.13 0.465 113 1130 FALSE 0.332547047110046 -0.0716 0.0979 0.00521 0.26 0.984 1.01 0.6 1.68 -0.588 0.299 0.0493 0.555 0.301 0.997 -0.0552 0.262 0.833 0.946 0.562 1.59 ukb-melanoma-latest-gwas all 650 Normal delivery Pregnancy Complications Female 0.945 0.902 0.991 0.0191 1925 19003 TRUE 1.71896663275227 -0.0562 0.024 0.0567 0.0656 0.387 1.06 0.931 1.2 -0.137 0.0686 0.0458 0.872 0.762 0.997 -0.0998 0.0682 0.143 0.905 0.792 1.03 ukb-melanoma-latest-gwas all 651 Multiple gestation Pregnancy Complications Female 1.12 1 1.25 0.0463 346 3460 TRUE 1.33441900898205 0.113 0.0567 0.0119 0.171 0.944 1.01 0.722 1.42 0.252 0.163 0.122 1.29 0.935 1.78 0.357 0.16 0.0259 1.43 1.04 1.96 ukb-melanoma-latest-gwas all 652 Malposition and malpresentation of fetus or obstruction Pregnancy Complications Female 1.03 0.976 1.08 0.314 1718 16535 FALSE 0.503070351926785 0.0256 0.0254 -0.093 0.0723 0.198 0.911 0.791 1.05 -0.0829 0.0721 0.25 0.92 0.799 1.06 0.053 0.0702 0.451 1.05 0.919 1.21 ukb-melanoma-latest-gwas all 653 Problems associated with amniotic cavity and membranes Pregnancy Complications Female 1.01 0.953 1.06 0.795 1401 13662 FALSE 0.0996328713435297 0.00732 0.0281 0.0945 0.079 0.232 1.1 0.941 1.28 -0.0081 0.0809 0.92 0.992 0.846 1.16 0.0682 0.0799 0.393 1.07 0.915 1.25 ukb-melanoma-latest-gwas all 654 Other and unspecified complications of birth; puerperium affecting management of mother Pregnancy Complications Female 1.14 0.897 1.45 0.273 74 740 FALSE 0.563837352959244 0.133 0.122 -0.373 0.379 0.324 0.689 0.314 1.47 0.355 0.329 0.28 1.43 0.747 2.78 0.176 0.34 0.605 1.19 0.607 2.37 ukb-melanoma-latest-gwas all 655 Known or suspected fetal abnormality affecting management of mother Pregnancy Complications Female 1.01 0.974 1.04 0.73 4309 29472 FALSE 0.136677139879544 0.0057 0.0165 -0.0051 0.047 0.914 0.995 0.907 1.09 0.0298 0.0465 0.521 1.03 0.94 1.13 0.0246 0.0468 0.598 1.02 0.935 1.12 ukb-melanoma-latest-gwas all 656 Other perinatal conditions of fetus or newborn Pregnancy Complications Both 0.832 0.682 1.01 0.0657 110 1090 FALSE 1.18243463044022 -0.184 0.1 -0.16 0.262 0.543 0.852 0.504 1.43 -0.284 0.272 0.297 0.753 0.437 1.28 -0.578 0.291 0.0471 0.561 0.31 0.99 ukb-melanoma-latest-gwas all 661 Fetal distress and abnormal forces of labor Pregnancy Complications Female 0.991 0.948 1.04 0.689 2267 18423 FALSE 0.161780778092374 -0.00897 0.0224 -0.155 0.0638 0.0153 0.857 0.756 0.971 -0.0763 0.0626 0.223 0.927 0.819 1.05 -0.0222 0.062 0.72 0.978 0.866 1.1 ukb-melanoma-latest-gwas all 663 Umbilical cord complications during labor and delivery Pregnancy Complications Female 1.03 0.941 1.13 0.53 533 5319 FALSE 0.275724130399211 0.0286 0.0455 -0.0165 0.13 0.899 0.984 0.762 1.27 -0.0131 0.129 0.919 0.987 0.765 1.27 0.0948 0.126 0.453 1.1 0.858 1.41 ukb-melanoma-latest-gwas all 665 Obstetrical/birth trauma Pregnancy Complications Female 0.983 0.954 1.01 0.251 5314 29494 FALSE 0.600326278518962 -0.0175 0.0152 -0.0484 0.0429 0.259 0.953 0.876 1.04 -0.0318 0.0428 0.457 0.969 0.891 1.05 -0.0317 0.0429 0.46 0.969 0.891 1.05 ukb-melanoma-latest-gwas all 669 Complications of labor and delivery NEC Pregnancy Complications Female 1.03 0.984 1.07 0.238 2554 21200 FALSE 0.623423042943488 0.0249 0.0211 0.0401 0.0601 0.505 1.04 0.925 1.17 0.0493 0.06 0.411 1.05 0.934 1.18 0.0836 0.0598 0.162 1.09 0.967 1.22 ukb-melanoma-latest-gwas all 671 Venous/cerebrovascular complications embolism in pregnancy and the puerperium Pregnancy Complications Female 1.15 0.982 1.36 0.0823 164 1630 FALSE 1.08460016478773 0.143 0.0825 0.243 0.242 0.314 1.28 0.792 2.07 0.328 0.239 0.17 1.39 0.869 2.24 0.325 0.239 0.174 1.38 0.866 2.23 ukb-melanoma-latest-gwas all 674 Other complications of the puerperium NEC Pregnancy Complications Female 1.03 0.903 1.16 0.697 262 2609 FALSE 0.156767221901991 0.0252 0.0648 -0.0515 0.185 0.781 0.95 0.658 1.37 -0.0708 0.186 0.703 0.932 0.645 1.34 0.135 0.177 0.446 1.14 0.808 1.62 ukb-melanoma-latest-gwas all 676 Other disorders of the breast associated with childbirth and disorders of lactation Pregnancy Complications Female 1.01 0.781 1.31 0.924 63 624 FALSE 0.0343280287798933 0.0123 0.13 -0.0254 0.37 0.945 0.975 0.464 2.05 0.155 0.364 0.67 1.17 0.565 2.44 -0.0479 0.371 0.897 0.953 0.45 2.02 ukb-melanoma-latest-gwas all 679 Complications of in utero procedures Dermatologic Female 0.957 0.721 1.27 0.759 53 530 FALSE 0.11975822410452 -0.0435 0.142 -0.303 0.399 0.447 0.738 0.325 1.63 -0.0665 0.38 0.861 0.936 0.435 2 -0.15 0.389 0.699 0.86 0.39 1.88 ukb-melanoma-latest-gwas all 681 Superficial cellulitis and abscess Dermatologic Both 1.03 1.01 1.06 0.00987 7421 74210 TRUE 2.00568284733036 0.0316 0.0122 0.0063 0.0348 0.856 1.01 0.94 1.08 0.00893 0.0348 0.798 1.01 0.942 1.08 0.0798 0.0344 0.0205 1.08 1.01 1.16 ukb-melanoma-latest-gwas all 681.1 Cellulitis and abscess of fingers/toes Dermatologic Both 1.01 0.926 1.1 0.816 566 5660 FALSE 0.0883098412461389 0.0103 0.0442 -0.0134 0.124 0.914 0.987 0.773 1.26 -0.115 0.127 0.364 0.891 0.694 1.14 0.0567 0.123 0.645 1.06 0.831 1.35 ukb-melanoma-latest-gwas all 681.2 Cellulitis and abscess of face/neck Dermatologic Both 1.09 0.999 1.2 0.053 522 5220 FALSE 1.27572413039921 0.0897 0.0464 -0.00636 0.133 0.962 0.994 0.765 1.29 -0.074 0.136 0.586 0.929 0.71 1.21 0.261 0.127 0.0403 1.3 1.01 1.67 ukb-melanoma-latest-gwas all 681.3 Cellulitis and abscess of arm/hand Dermatologic Both 1.03 0.999 1.06 0.0563 5514 55140 FALSE 1.24949160514865 0.0271 0.0142 0.00734 0.0403 0.855 1.01 0.931 1.09 0.00307 0.0404 0.939 1 0.927 1.09 0.0708 0.0399 0.076 1.07 0.993 1.16 ukb-melanoma-latest-gwas all 681.5 Cellulitis and abscess of leg, except foot Dermatologic Both 1.03 0.999 1.06 0.0562 5521 55210 FALSE 1.25026368443094 0.0271 0.0142 0.00252 0.0403 0.95 1 0.926 1.08 0.00904 0.0403 0.822 1.01 0.932 1.09 0.0685 0.0399 0.0862 1.07 0.99 1.16 ukb-melanoma-latest-gwas all 681.6 Cellulitis and abscess of foot, toe Dermatologic Both 1.03 0.999 1.06 0.0549 5477 54770 FALSE 1.26042765554991 0.0273 0.0142 0.00501 0.0404 0.901 1.01 0.928 1.09 0.00395 0.0405 0.922 1 0.927 1.09 0.0696 0.0401 0.0823 1.07 0.991 1.16 ukb-melanoma-latest-gwas all 681.7 Cellulitis and abscess of trunk Dermatologic Both 1.06 0.971 1.15 0.204 600 6000 FALSE 0.690369832574101 0.0546 0.043 -0.138 0.124 0.264 0.871 0.682 1.11 0.00151 0.12 0.99 1 0.791 1.27 0.0666 0.119 0.575 1.07 0.846 1.35 ukb-melanoma-latest-gwas all 686 Other local infections of skin and subcutaneous tissue Dermatologic Both 1.07 1.01 1.13 0.0151 1348 13480 TRUE 1.82102305270683 0.0698 0.0287 0.0351 0.0836 0.674 1.04 0.879 1.22 0.19 0.0809 0.0187 1.21 1.03 1.42 0.13 0.0822 0.113 1.14 0.969 1.34 ukb-melanoma-latest-gwas all 686.1 Carbuncle and furuncle Dermatologic Both 1.01 0.813 1.26 0.901 87 870 FALSE 0.045275209020937 0.0138 0.111 -0.369 0.332 0.267 0.691 0.35 1.34 0.229 0.296 0.438 1.26 0.701 2.28 -0.149 0.315 0.636 0.862 0.456 1.61 ukb-melanoma-latest-gwas all 687 Symptoms affecting skin Dermatologic Both 1.07 0.982 1.16 0.126 604 6040 FALSE 0.899629454882437 0.0657 0.0429 0.0307 0.125 0.805 1.03 0.807 1.32 0.122 0.122 0.317 1.13 0.889 1.44 0.186 0.121 0.124 1.2 0.95 1.53 ukb-melanoma-latest-gwas all 687.2 Localized superficial swelling, mass, or lump Dermatologic Both 1.07 0.949 1.21 0.258 284 2840 FALSE 0.58838029403677 0.0706 0.0624 0.0671 0.179 0.708 1.07 0.75 1.53 0.0588 0.181 0.745 1.06 0.743 1.52 0.243 0.175 0.165 1.27 0.905 1.8 ukb-melanoma-latest-gwas all 687.3 Changes in skin texture Dermatologic Both 0.994 0.815 1.21 0.951 108 1080 FALSE 0.0218194830625861 -0.00617 0.1 0.0727 0.279 0.794 1.08 0.618 1.88 -0.194 0.295 0.51 0.824 0.455 1.48 0.0861 0.278 0.757 1.09 0.627 1.9 ukb-melanoma-latest-gwas all 689 Disorder of skin and subcutaneous tissue NOS Dermatologic Both 1.09 1.06 1.12 1.63e-10 5765 57650 TRUE 9.78781239559604 0.0889 0.0139 0.0823 0.0404 0.0417 1.09 1 1.18 0.146 0.0399 0.000244 1.16 1.07 1.25 0.208 0.0396 1.49e-07 1.23 1.14 1.33 ukb-melanoma-latest-gwas all 690 Erythematosquamous dermatosis Dermatologic Both 0.89 0.698 1.13 0.34 72 720 FALSE 0.468521082957745 -0.116 0.122 0.165 0.33 0.617 1.18 0.611 2.3 0.145 0.33 0.66 1.16 0.601 2.25 -0.373 0.375 0.32 0.689 0.317 1.45 ukb-melanoma-latest-gwas all 690.1 Seborrheic dermatitis Dermatologic Both 0.956 0.722 1.27 0.752 53 530 FALSE 0.123782159408358 -0.0445 0.141 0.335 0.385 0.384 1.4 0.649 3.09 0.192 0.393 0.624 1.21 0.553 2.71 -0.214 0.434 0.622 0.807 0.326 1.94 ukb-melanoma-latest-gwas all 691 Congenital anomalies of skin Dermatologic Both 1.2 0.993 1.46 0.0584 120 1200 FALSE 1.2335871528876 0.184 0.0973 0.487 0.286 0.088 1.63 0.929 2.91 0.379 0.289 0.19 1.46 0.825 2.63 0.55 0.285 0.0532 1.73 0.992 3.1 ukb-melanoma-latest-gwas all 694 Dyschromia and Vitiligo Dermatologic Both 1.08 1.01 1.16 0.0186 987 9864 TRUE 1.73048705578208 0.079 0.0336 0.134 0.0973 0.167 1.14 0.945 1.39 0.0954 0.098 0.331 1.1 0.908 1.33 0.279 0.0953 0.00345 1.32 1.1 1.59 ukb-melanoma-latest-gwas all 694.1 Vitiligo Dermatologic Both 0.918 0.703 1.2 0.519 60 600 FALSE 0.284832642151542 -0.0858 0.133 0.0633 0.346 0.855 1.07 0.532 2.14 -0.684 0.423 0.106 0.505 0.204 1.16 -0.0539 0.352 0.878 0.948 0.467 1.92 ukb-melanoma-latest-gwas all 694.2 Other dyschromia Dermatologic Both 1.13 1.05 1.22 0.0014 783 7830 TRUE 2.85387196432176 0.121 0.0378 0.176 0.111 0.113 1.19 0.959 1.48 0.161 0.111 0.148 1.17 0.944 1.46 0.379 0.107 0.000423 1.46 1.18 1.81 ukb-melanoma-latest-gwas all 694.3 Vascular disorders of skin Dermatologic Both 0.943 0.779 1.14 0.543 117 1164 FALSE 0.265200170411153 -0.0588 0.0966 0.0109 0.266 0.967 1.01 0.595 1.72 0.0717 0.262 0.784 1.07 0.639 1.81 -0.214 0.284 0.451 0.807 0.455 1.42 ukb-melanoma-latest-gwas all 695 Erythematous conditions Dermatologic Both 1.05 1 1.09 0.0348 2416 24160 TRUE 1.45842075605342 0.0453 0.0215 0.0134 0.0612 0.827 1.01 0.899 1.14 -0.0312 0.0618 0.613 0.969 0.859 1.09 0.15 0.0597 0.0122 1.16 1.03 1.31 ukb-melanoma-latest-gwas all 695.1 Toxic erythema Dermatologic Both 1.03 0.843 1.25 0.78 109 1090 FALSE 0.10790539730952 0.0279 0.0998 0.028 0.28 0.92 1.03 0.588 1.8 -0.168 0.291 0.564 0.845 0.47 1.51 0.159 0.272 0.557 1.17 0.685 2.02 ukb-melanoma-latest-gwas all 695.2 Bullous dermatoses Dermatologic Both 1.18 0.988 1.4 0.0664 141 1410 FALSE 1.17783192063198 0.162 0.0885 -0.218 0.255 0.393 0.804 0.481 1.33 -0.256 0.258 0.32 0.774 0.46 1.29 0.26 0.233 0.264 1.3 0.82 2.06 ukb-melanoma-latest-gwas all 695.3 Rosacea Dermatologic Both 1.14 1.02 1.29 0.0245 310 3100 TRUE 1.61083391563547 0.134 0.0598 0.156 0.176 0.375 1.17 0.827 1.66 0.215 0.173 0.215 1.24 0.882 1.75 0.326 0.171 0.0563 1.39 0.991 1.95 ukb-melanoma-latest-gwas all 695.4 Lupus (localized and systemic) Dermatologic Both 1.04 0.938 1.15 0.477 418 4180 FALSE 0.321481620959886 0.0365 0.0514 -0.0119 0.145 0.934 0.988 0.743 1.31 -0.162 0.151 0.281 0.85 0.631 1.14 0.165 0.14 0.24 1.18 0.896 1.55 ukb-melanoma-latest-gwas all 695.7 Prurigo and Lichen Dermatologic Both 1.01 0.938 1.09 0.799 777 7770 FALSE 0.0974532206860086 0.00963 0.0377 0.106 0.105 0.312 1.11 0.905 1.37 -0.106 0.11 0.338 0.9 0.724 1.12 0.0974 0.106 0.357 1.1 0.896 1.36 ukb-melanoma-latest-gwas all 695.8 Other specified erythematous conditions Dermatologic Both 0.986 0.864 1.13 0.837 242 2420 FALSE 0.07727454200674 -0.0138 0.0673 -0.135 0.192 0.483 0.874 0.597 1.28 -0.0105 0.186 0.955 0.99 0.685 1.43 -0.0387 0.188 0.837 0.962 0.664 1.39 ukb-melanoma-latest-gwas all 695.9 Unspecified erythematous condition Dermatologic Both 1.06 0.961 1.16 0.253 468 4680 FALSE 0.596879478824182 0.0556 0.0486 0.0765 0.141 0.588 1.08 0.818 1.43 0.192 0.138 0.164 1.21 0.924 1.59 0.179 0.139 0.199 1.2 0.909 1.58 ukb-melanoma-latest-gwas all 695.21 Dermatitis herpetiformis Dermatologic Both 1.09 0.83 1.44 0.519 57 570 FALSE 0.284832642151542 0.0884 0.137 -0.183 0.384 0.635 0.833 0.38 1.8 -0.347 0.399 0.384 0.707 0.31 1.57 0.1 0.364 0.783 1.11 0.534 2.31 ukb-melanoma-latest-gwas all 695.22 Pemphigus and pemphigoid Dermatologic Both 1.33 1.05 1.7 0.018 75 750 TRUE 1.74472749489669 0.286 0.121 -0.158 0.359 0.66 0.854 0.409 1.76 -0.189 0.361 0.6 0.828 0.395 1.71 0.516 0.316 0.103 1.68 0.902 3.19 ukb-melanoma-latest-gwas all 695.41 Cutaneous lupus erythematosus Dermatologic Both 1.05 0.874 1.25 0.618 130 1300 FALSE 0.209011524911184 0.0455 0.0911 -0.0515 0.257 0.841 0.95 0.569 1.58 -0.241 0.268 0.368 0.786 0.458 1.34 0.191 0.244 0.435 1.21 0.747 1.97 ukb-melanoma-latest-gwas all 695.42 Systemic lupus erythematosus Dermatologic Both 1.01 0.901 1.13 0.9 342 3420 FALSE 0.0457574905606751 0.00716 0.0568 -0.0496 0.16 0.756 0.952 0.694 1.3 -0.145 0.164 0.378 0.865 0.625 1.2 0.114 0.155 0.462 1.12 0.826 1.52 ukb-melanoma-latest-gwas all 695.81 Erythema nodosum Dermatologic Both 0.969 0.767 1.23 0.791 76 760 FALSE 0.101823516502323 -0.0313 0.118 -0.661 0.347 0.0571 0.516 0.251 1.02 -0.542 0.336 0.106 0.581 0.292 1.12 -0.0691 0.301 0.818 0.933 0.512 1.7 ukb-melanoma-latest-gwas all 696 Psoriasis and related disorders Dermatologic Both 1 0.958 1.04 0.977 2290 22900 FALSE 0.0101054362812269 0.000631 0.022 -0.0296 0.0624 0.635 0.971 0.859 1.1 0.0382 0.0616 0.535 1.04 0.921 1.17 -0.0217 0.0626 0.729 0.979 0.865 1.11 ukb-melanoma-latest-gwas all 696.4 Psoriasis Dermatologic Both 1 0.958 1.05 0.987 2234 22340 FALSE 0.00568284733036327 0.000374 0.0223 -0.0138 0.0632 0.826 0.986 0.871 1.12 0.0498 0.0624 0.425 1.05 0.93 1.19 -0.028 0.0636 0.66 0.972 0.858 1.1 ukb-melanoma-latest-gwas all 696.41 Psoriasis vulgaris Dermatologic Both 0.997 0.948 1.05 0.907 1681 16810 FALSE 0.0423927129399047 -0.00299 0.0257 -0.0442 0.0727 0.543 0.957 0.829 1.1 8.12e-05 0.0721 0.999 1 0.868 1.15 -0.00907 0.0726 0.9 0.991 0.859 1.14 ukb-melanoma-latest-gwas all 696.42 Psoriatic arthropathy Dermatologic Both 1.03 0.951 1.11 0.495 708 7080 FALSE 0.305394801066431 0.027 0.0396 0.0574 0.113 0.612 1.06 0.848 1.32 0.174 0.11 0.114 1.19 0.959 1.48 -0.0258 0.115 0.823 0.975 0.777 1.22 ukb-melanoma-latest-gwas all 697 Sarcoidosis Dermatologic Both 1.02 0.93 1.11 0.732 549 5480 FALSE 0.135488918941608 0.0154 0.045 -0.0821 0.129 0.523 0.921 0.715 1.19 -0.0369 0.128 0.773 0.964 0.749 1.24 0.0838 0.125 0.501 1.09 0.851 1.39 ukb-melanoma-latest-gwas all 698 Pruritus and related conditions Dermatologic Both 1.04 0.968 1.12 0.272 783 7830 FALSE 0.565431095965801 0.0414 0.0377 -0.0281 0.108 0.795 0.972 0.786 1.2 0.095 0.105 0.367 1.1 0.894 1.35 0.0456 0.107 0.669 1.05 0.849 1.29 ukb-melanoma-latest-gwas all 700 Corns and callosities Dermatologic Both 1.01 0.899 1.14 0.823 293 2930 FALSE 0.0846001647877302 0.0137 0.0614 -0.0236 0.173 0.891 0.977 0.694 1.37 -0.11 0.175 0.532 0.896 0.633 1.27 0.145 0.17 0.394 1.16 0.827 1.62 ukb-melanoma-latest-gwas all 701 Other hypertrophic and atrophic conditions of skin Dermatologic Both 1.1 1.06 1.13 1.69e-09 4782 47820 TRUE 8.77211329538633 0.0919 0.0152 0.088 0.0443 0.0469 1.09 1 1.19 0.0949 0.0443 0.0322 1.1 1.01 1.2 0.25 0.043 6.18e-09 1.28 1.18 1.4 ukb-melanoma-latest-gwas all 701.1 Keratoderma, acquired Dermatologic Both 1.48 1.18 1.86 0.000658 86 860 TRUE 3.18177410638604 0.391 0.115 0.0791 0.354 0.823 1.08 0.528 2.23 0.238 0.345 0.491 1.27 0.635 2.57 0.887 0.314 0.00471 2.43 1.32 4.66 ukb-melanoma-latest-gwas all 701.2 Scar conditions and fibrosis of skin Dermatologic Both 1.13 1.08 1.18 4.78e-08 2350 23500 TRUE 7.32057210338788 0.119 0.0218 0.12 0.0641 0.0601 1.13 0.995 1.28 0.145 0.0638 0.0229 1.16 1.02 1.31 0.332 0.0616 6.78e-08 1.39 1.24 1.57 ukb-melanoma-latest-gwas all 701.3 Circumscribed scleroderma Dermatologic Both 0.827 0.632 1.08 0.159 59 590 FALSE 0.798602875679548 -0.19 0.135 0.459 0.362 0.205 1.58 0.777 3.33 -0.0848 0.403 0.833 0.919 0.402 2.08 -0.051 0.4 0.899 0.95 0.421 2.14 ukb-melanoma-latest-gwas all 701.4 Keloid scar Dermatologic Both 1.05 0.917 1.21 0.455 216 2160 FALSE 0.341988603342888 0.053 0.071 0.361 0.199 0.0693 1.43 0.972 2.13 -0.253 0.224 0.26 0.777 0.495 1.21 0.322 0.199 0.105 1.38 0.935 2.05 ukb-melanoma-latest-gwas all 701.5 Abnormal granulation tissue Dermatologic Both 1.06 0.958 1.16 0.275 454 4540 FALSE 0.560667306169737 0.0538 0.0492 0.114 0.142 0.42 1.12 0.849 1.48 0.142 0.141 0.315 1.15 0.873 1.52 0.171 0.141 0.228 1.19 0.898 1.57 ukb-melanoma-latest-gwas all 701.6 Acquired acanthosis nigricans Dermatologic Both 1.16 0.948 1.43 0.143 102 1020 FALSE 0.844663962534938 0.152 0.104 0.34 0.306 0.266 1.4 0.767 2.62 0.335 0.307 0.276 1.4 0.76 2.61 0.502 0.301 0.0955 1.65 0.915 3.05 ukb-melanoma-latest-gwas all 702 Degenerative skin conditions and other dermatoses Dermatologic Both 1.16 1.13 1.19 2.13e-25 5492 54920 TRUE 24.6716203965613 0.149 0.0143 0.182 0.0425 1.94e-05 1.2 1.1 1.3 0.265 0.0418 2.29e-10 1.3 1.2 1.42 0.385 0.041 6.47e-21 1.47 1.36 1.59 ukb-melanoma-latest-gwas all 702.1 Actinic keratosis Dermatologic Both 1.21 1.16 1.26 8.26e-20 2581 25810 TRUE 19.0830199526796 0.19 0.0209 0.121 0.0629 0.0538 1.13 0.998 1.28 0.242 0.0614 8.24e-05 1.27 1.13 1.44 0.465 0.0591 3.58e-15 1.59 1.42 1.79 ukb-melanoma-latest-gwas all 702.2 Seborrheic keratosis Dermatologic Both 1.12 1.08 1.17 7.41e-10 3075 30750 TRUE 9.13018179202067 0.117 0.0191 0.229 0.0561 4.41e-05 1.26 1.13 1.4 0.27 0.0557 1.21e-06 1.31 1.18 1.46 0.321 0.0553 6.94e-09 1.38 1.24 1.54 ukb-melanoma-latest-gwas all 703 Diseases of nail, NOS Dermatologic Both 0.994 0.891 1.11 0.911 355 3546 FALSE 0.0404816230270017 -0.00621 0.0556 -0.0139 0.152 0.927 0.986 0.731 1.33 -0.324 0.164 0.0479 0.723 0.522 0.997 -0.0102 0.152 0.946 0.99 0.734 1.33 ukb-melanoma-latest-gwas all 704 Diseases of hair and hair follicles Dermatologic Both 1.05 1.02 1.08 0.00102 5287 52864 TRUE 2.99139982823808 0.0476 0.0145 0.0733 0.0415 0.0771 1.08 0.992 1.17 0.0394 0.0418 0.346 1.04 0.958 1.13 0.158 0.0409 0.000114 1.17 1.08 1.27 ukb-melanoma-latest-gwas all 704.1 Alopecia Dermatologic Both 0.862 0.718 1.03 0.109 127 1270 FALSE 0.962573502059376 -0.148 0.0924 -0.162 0.246 0.511 0.851 0.521 1.38 -0.53 0.27 0.0499 0.589 0.34 0.998 -0.213 0.25 0.394 0.808 0.491 1.32 ukb-melanoma-latest-gwas all 704.8 Other specified diseases of hair and hair follicles Dermatologic Both 0.931 0.736 1.18 0.545 76 760 FALSE 0.263603497723358 -0.0718 0.119 0.152 0.314 0.628 1.16 0.624 2.19 -0.199 0.341 0.561 0.82 0.41 1.62 -0.297 0.346 0.39 0.743 0.367 1.47 ukb-melanoma-latest-gwas all 705 Disorders of sweat glands Dermatologic Both 1.08 0.944 1.24 0.252 229 2289 FALSE 0.598599459218456 0.0797 0.0696 0.339 0.204 0.0968 1.4 0.94 2.11 0.285 0.207 0.168 1.33 0.886 2.01 0.379 0.204 0.0641 1.46 0.978 2.2 ukb-melanoma-latest-gwas all 705.3 Hidradenitis Dermatologic Both 1.12 0.963 1.3 0.139 187 1869 FALSE 0.856985199745905 0.114 0.077 0.418 0.228 0.0665 1.52 0.972 2.4 0.282 0.235 0.23 1.33 0.834 2.12 0.482 0.226 0.0331 1.62 1.04 2.56 ukb-melanoma-latest-gwas all 706 Diseases of sebaceous glands Dermatologic Both 1.05 1.03 1.07 1.05e-05 8876 88734 TRUE 4.97881070093006 0.0493 0.0112 0.0856 0.0321 0.00756 1.09 1.02 1.16 0.0659 0.0322 0.041 1.07 1 1.14 0.157 0.0317 7.1e-07 1.17 1.1 1.25 ukb-melanoma-latest-gwas all 706.1 Acne Dermatologic Both 0.815 0.645 1.03 0.0792 78 780 FALSE 1.10127481841051 -0.205 0.117 -0.187 0.321 0.561 0.83 0.434 1.57 -0.219 0.319 0.492 0.803 0.422 1.51 -0.312 0.33 0.345 0.732 0.373 1.41 ukb-melanoma-latest-gwas all 706.2 Sebaceous cyst Dermatologic Both 1.05 1.03 1.08 5.3e-06 8804 88014 TRUE 5.27572413039921 0.0512 0.0112 0.0904 0.0322 0.005 1.09 1.03 1.17 0.0697 0.0324 0.0315 1.07 1.01 1.14 0.163 0.0319 3.08e-07 1.18 1.11 1.25 ukb-melanoma-latest-gwas all 707 Chronic ulcer of skin Dermatologic Both 1.01 0.968 1.06 0.558 1990 19900 FALSE 0.253365801062421 0.0138 0.0236 0.0298 0.0667 0.655 1.03 0.904 1.17 -0.0097 0.0674 0.886 0.99 0.868 1.13 0.0672 0.0666 0.313 1.07 0.939 1.22 ukb-melanoma-latest-gwas all 707.1 Decubitus ulcer Dermatologic Both 1.01 0.948 1.09 0.677 913 9130 FALSE 0.169411331314856 0.0145 0.0348 0.106 0.098 0.281 1.11 0.917 1.35 -0.00207 0.101 0.984 0.998 0.819 1.22 0.0982 0.0987 0.32 1.1 0.909 1.34 ukb-melanoma-latest-gwas all 709 Diffuse diseases of connective tissue Dermatologic Both 0.998 0.964 1.03 0.918 3451 34510 FALSE 0.0371573187987575 -0.00184 0.0179 -0.00952 0.0508 0.851 0.991 0.897 1.09 -0.0071 0.0508 0.889 0.993 0.899 1.1 0.0423 0.0504 0.402 1.04 0.945 1.15 ukb-melanoma-latest-gwas all 709.2 Sicca syndrome Dermatologic Both 0.965 0.88 1.06 0.446 504 5040 FALSE 0.350665141287858 -0.0356 0.0467 -0.153 0.132 0.245 0.858 0.661 1.11 -0.0444 0.129 0.731 0.957 0.742 1.23 -0.109 0.131 0.405 0.897 0.693 1.16 ukb-melanoma-latest-gwas all 709.3 Systemic sclerosis Dermatologic Both 1.01 0.861 1.18 0.943 174 1740 FALSE 0.0254883072626717 0.00566 0.079 0.239 0.224 0.287 1.27 0.816 1.99 0.147 0.228 0.52 1.16 0.737 1.83 0.164 0.23 0.474 1.18 0.749 1.86 ukb-melanoma-latest-gwas all 709.6 Other specified diffuse diseases of connective tissue Dermatologic Both 1.04 0.804 1.34 0.768 65 650 FALSE 0.114638779968488 0.0378 0.128 0.241 0.358 0.502 1.27 0.624 2.64 0.126 0.384 0.743 1.13 0.522 2.48 0.31 0.361 0.39 1.36 0.664 2.85 ukb-melanoma-latest-gwas all 709.7 Unspecified diffuse connective tissue disease Dermatologic Both 1 0.964 1.04 0.879 2721 27210 FALSE 0.0560111249262281 0.00307 0.0202 0.0177 0.0572 0.757 1.02 0.91 1.14 -1.4e-05 0.0574 1 1 0.893 1.12 0.0639 0.0569 0.262 1.07 0.953 1.19 ukb-melanoma-latest-gwas all 710 Osteomyelitis, periostitis, and other infections involving bone Musculoskeletal Both 1.03 0.944 1.12 0.542 613 6130 FALSE 0.266000713461613 0.026 0.0426 -0.0772 0.122 0.528 0.926 0.727 1.18 0.0823 0.118 0.487 1.09 0.86 1.37 0.0305 0.12 0.8 1.03 0.814 1.31 ukb-melanoma-latest-gwas all 710.1 Osteomyelitis Musculoskeletal Both 1.04 0.951 1.13 0.401 566 5660 FALSE 0.396855627379818 0.0372 0.0444 -0.0534 0.127 0.674 0.948 0.739 1.22 0.0417 0.124 0.737 1.04 0.816 1.33 0.0599 0.125 0.631 1.06 0.831 1.36 ukb-melanoma-latest-gwas all 710.12 Chronic osteomyelitis Musculoskeletal Both 1.06 0.914 1.23 0.441 196 1960 FALSE 0.355561410532161 0.0583 0.0756 0.0316 0.214 0.883 1.03 0.675 1.58 0.0151 0.214 0.944 1.02 0.665 1.55 0.159 0.211 0.451 1.17 0.773 1.78 ukb-melanoma-latest-gwas all 710.19 Unspecified osteomyelitis Musculoskeletal Both 1.03 0.926 1.14 0.613 402 4020 FALSE 0.212539525481585 0.0265 0.0525 -0.187 0.152 0.221 0.83 0.614 1.12 0.0538 0.145 0.71 1.06 0.794 1.4 0.0215 0.146 0.883 1.02 0.767 1.36 ukb-melanoma-latest-gwas all 711 Arthropathy associated with infections Musculoskeletal Both 1.02 0.92 1.12 0.743 429 4290 FALSE 0.129011186239425 0.0166 0.0507 -0.0614 0.146 0.673 0.94 0.706 1.25 0.14 0.14 0.319 1.15 0.873 1.52 0.00128 0.145 0.993 1 0.753 1.33 ukb-melanoma-latest-gwas all 711.1 Pyogenic arthritis Musculoskeletal Both 1.05 0.936 1.18 0.409 330 3300 FALSE 0.388276691992658 0.0477 0.0578 -0.0433 0.167 0.795 0.958 0.689 1.33 0.141 0.161 0.384 1.15 0.838 1.58 0.0767 0.164 0.639 1.08 0.782 1.49 ukb-melanoma-latest-gwas all 712 Infective connective tissue disorders Musculoskeletal Both 0.867 0.691 1.09 0.21 82 820 FALSE 0.677780705266081 -0.143 0.114 -0.0273 0.296 0.926 0.973 0.539 1.75 -0.489 0.335 0.145 0.614 0.308 1.19 -0.322 0.323 0.319 0.725 0.377 1.37 ukb-melanoma-latest-gwas all 713 Arthropathy associated with other disorders classified elsewhere Musculoskeletal Both 1.06 0.896 1.25 0.49 151 1510 FALSE 0.309803919971486 0.0585 0.0848 -0.0676 0.247 0.784 0.935 0.571 1.53 0.00405 0.245 0.987 1 0.617 1.63 0.228 0.233 0.327 1.26 0.794 2 ukb-melanoma-latest-gwas all 713.5 Arthropathy associated with neurological disorders Musculoskeletal Both 1.09 0.85 1.41 0.479 68 680 FALSE 0.319664486585437 0.09 0.127 0.135 0.36 0.708 1.14 0.556 2.38 0.2 0.36 0.578 1.22 0.595 2.54 0.0653 0.361 0.857 1.07 0.516 2.22 ukb-melanoma-latest-gwas all 714 Rheumatoid arthritis and other inflammatory polyarthropathies Musculoskeletal Both 1.01 0.984 1.04 0.382 4858 48575 FALSE 0.417936637088291 0.0132 0.0151 -0.06 0.0429 0.162 0.942 0.866 1.02 -0.0167 0.0425 0.694 0.983 0.905 1.07 0.0168 0.0423 0.691 1.02 0.936 1.11 ukb-melanoma-latest-gwas all 714.1 Rheumatoid arthritis Musculoskeletal Both 1.02 0.994 1.06 0.121 4394 43935 FALSE 0.91721462968355 0.0246 0.0159 -0.0353 0.0453 0.435 0.965 0.883 1.05 0.00737 0.0449 0.869 1.01 0.923 1.1 0.0493 0.0446 0.27 1.05 0.963 1.15 ukb-melanoma-latest-gwas all 715 Other inflammatory spondylopathies Musculoskeletal Both 1.01 0.963 1.06 0.629 1670 16700 FALSE 0.201349354554731 0.0124 0.0257 0.133 0.0721 0.0661 1.14 0.991 1.32 -4.74e-05 0.0743 0.999 1 0.864 1.16 0.0687 0.0733 0.349 1.07 0.928 1.24 ukb-melanoma-latest-gwas all 715.1 Sacroiliitis NEC Musculoskeletal Both 0.921 0.758 1.12 0.399 113 1130 FALSE 0.399027104313252 -0.0825 0.0978 9.61e-05 0.27 1 1 0.583 1.71 0.00863 0.27 0.975 1.01 0.589 1.73 -0.137 0.28 0.623 0.872 0.497 1.52 ukb-melanoma-latest-gwas all 715.2 Ankylosing spondylitis Musculoskeletal Both 0.991 0.912 1.08 0.832 619 6190 FALSE 0.0798766737092761 -0.00895 0.0421 0.224 0.118 0.0576 1.25 0.993 1.58 0.0708 0.122 0.561 1.07 0.845 1.36 0.0354 0.123 0.773 1.04 0.814 1.32 ukb-melanoma-latest-gwas all 716 Other arthropathies Musculoskeletal Both 1.01 1 1.03 0.0118 37608 265965 TRUE 1.92811799269387 0.014 0.00556 0.0198 0.0158 0.211 1.02 0.989 1.05 0.0352 0.0158 0.0255 1.04 1 1.07 0.039 0.0158 0.0135 1.04 1.01 1.07 ukb-melanoma-latest-gwas all 716.1 Unspecified polyarthropathy or polyarthritis Musculoskeletal Both 1.02 0.983 1.05 0.328 3517 35170 FALSE 0.484126156288321 0.0174 0.0178 0.015 0.0505 0.767 1.02 0.919 1.12 0.0324 0.0504 0.521 1.03 0.936 1.14 0.0595 0.0503 0.237 1.06 0.962 1.17 ukb-melanoma-latest-gwas all 716.2 Unspecified monoarthritis Musculoskeletal Both 1.01 0.995 1.03 0.174 15561 155610 FALSE 0.7594507517174 0.0115 0.00844 0.0467 0.024 0.0516 1.05 1 1.1 0.0535 0.024 0.0256 1.05 1.01 1.11 0.0545 0.024 0.0233 1.06 1.01 1.11 ukb-melanoma-latest-gwas all 716.9 Arthropathy NOS Musculoskeletal Both 1.02 1 1.03 0.00869 35982 254727 TRUE 2.06098022355133 0.0149 0.00569 0.0236 0.0162 0.144 1.02 0.992 1.06 0.0383 0.0161 0.0175 1.04 1.01 1.07 0.0414 0.0161 0.0103 1.04 1.01 1.08 ukb-melanoma-latest-gwas all 717 Polymyalgia Rheumatica Musculoskeletal Both 0.987 0.929 1.05 0.683 1152 11520 FALSE 0.165579296318467 -0.0126 0.0309 -0.0501 0.086 0.56 0.951 0.803 1.13 -0.134 0.0878 0.127 0.875 0.736 1.04 -0.056 0.0862 0.516 0.946 0.798 1.12 ukb-melanoma-latest-gwas all 720 Spinal stenosis Musculoskeletal Both 1.01 0.972 1.04 0.763 3715 37150 FALSE 0.11747546204512 0.00522 0.0173 -0.0219 0.0489 0.654 0.978 0.889 1.08 -0.00937 0.0488 0.848 0.991 0.9 1.09 0.0289 0.0486 0.552 1.03 0.936 1.13 ukb-melanoma-latest-gwas all 721 Spondylosis and allied disorders Musculoskeletal Both 1.02 0.996 1.04 0.111 7872 78720 FALSE 0.954677021213343 0.0189 0.0119 0.00754 0.0336 0.823 1.01 0.943 1.08 0.019 0.0336 0.571 1.02 0.954 1.09 0.035 0.0336 0.297 1.04 0.97 1.11 ukb-melanoma-latest-gwas all 721.1 Spondylosis without myelopathy Musculoskeletal Both 1.01 0.982 1.04 0.452 5042 50420 FALSE 0.344861565188618 0.0111 0.0148 0.0582 0.0419 0.165 1.06 0.976 1.15 0.0376 0.0421 0.373 1.04 0.956 1.13 0.0385 0.0423 0.362 1.04 0.957 1.13 ukb-melanoma-latest-gwas all 721.2 Spondylosis with myelopathy Musculoskeletal Both 1.13 0.973 1.31 0.107 189 1890 FALSE 0.97061622231479 0.122 0.0759 0.0465 0.226 0.837 1.05 0.668 1.64 0.261 0.218 0.231 1.3 0.845 2.01 0.318 0.216 0.14 1.37 0.9 2.11 ukb-melanoma-latest-gwas all 721.8 Other allied disorders of spine Musculoskeletal Both 1.05 0.944 1.18 0.345 351 3510 FALSE 0.462180904926726 0.053 0.0562 0.0673 0.161 0.675 1.07 0.779 1.47 -0.0136 0.164 0.934 0.987 0.714 1.36 0.242 0.157 0.123 1.27 0.936 1.74 ukb-melanoma-latest-gwas all 722 Intervertebral disc disorders Musculoskeletal Both 0.997 0.976 1.02 0.82 9170 91700 FALSE 0.0861861476162833 -0.00251 0.011 0.0399 0.031 0.198 1.04 0.979 1.11 0.0072 0.0312 0.818 1.01 0.947 1.07 0.0113 0.0313 0.717 1.01 0.951 1.08 ukb-melanoma-latest-gwas all 722.1 Displacement of intervertebral disc Musculoskeletal Both 0.974 0.889 1.07 0.571 508 5080 FALSE 0.243363891754152 -0.0264 0.0467 0.0794 0.132 0.547 1.08 0.835 1.4 0.116 0.131 0.374 1.12 0.869 1.45 -0.029 0.135 0.83 0.971 0.744 1.27 ukb-melanoma-latest-gwas all 722.6 Degeneration of intervertebral disc Musculoskeletal Both 1.03 0.993 1.07 0.109 2826 28260 FALSE 0.962573502059376 0.0318 0.0198 0.1 0.0564 0.076 1.11 0.99 1.23 0.0795 0.0567 0.161 1.08 0.969 1.21 0.101 0.0566 0.0744 1.11 0.99 1.24 ukb-melanoma-latest-gwas all 722.8 Postlaminectomy syndrome Musculoskeletal Both 1.27 0.981 1.65 0.0674 67 670 FALSE 1.17134010346468 0.24 0.131 0.136 0.367 0.712 1.15 0.547 2.42 0.0697 0.373 0.852 1.07 0.504 2.29 0.399 0.353 0.259 1.49 0.742 3.08 ukb-melanoma-latest-gwas all 722.9 Other and unspecified disc disorder Musculoskeletal Both 0.975 0.945 1.01 0.104 4398 43980 FALSE 0.98296666070122 -0.0258 0.0159 0.018 0.0442 0.684 1.02 0.934 1.11 -0.0559 0.045 0.214 0.946 0.866 1.03 -0.0434 0.0451 0.336 0.958 0.877 1.05 ukb-melanoma-latest-gwas all 723 Other disorders of cervical region Musculoskeletal Both 0.968 0.884 1.06 0.474 521 5210 FALSE 0.324221658325915 -0.0329 0.046 -0.0636 0.129 0.621 0.938 0.728 1.21 0.0235 0.126 0.853 1.02 0.798 1.31 -0.143 0.132 0.278 0.867 0.668 1.12 ukb-melanoma-latest-gwas all 723.1 Torticollis Musculoskeletal Both 0.967 0.792 1.18 0.741 107 1070 FALSE 0.130181792020672 -0.0333 0.101 -0.1 0.286 0.726 0.905 0.509 1.6 0.0805 0.273 0.768 1.08 0.631 1.87 -0.128 0.283 0.651 0.88 0.499 1.54 ukb-melanoma-latest-gwas all 724 Other and unspecified disorders of back Musculoskeletal Both 1.01 0.963 1.05 0.753 2076 20760 FALSE 0.123205023799299 0.00727 0.0231 -0.0279 0.0652 0.669 0.972 0.856 1.11 -0.000334 0.0648 0.996 1 0.88 1.14 -0.0218 0.0654 0.739 0.978 0.861 1.11 ukb-melanoma-latest-gwas all 724.1 Disorders of sacrum Musculoskeletal Both 1.04 0.936 1.15 0.491 404 4040 FALSE 0.308918507877032 0.0359 0.0522 0.191 0.149 0.201 1.21 0.903 1.62 0.205 0.149 0.168 1.23 0.917 1.65 0.101 0.153 0.506 1.11 0.82 1.5 ukb-melanoma-latest-gwas all 724.2 Disorders of coccyx Musculoskeletal Both 1.03 0.927 1.14 0.611 407 4070 FALSE 0.213958789757446 0.0264 0.052 0.168 0.148 0.257 1.18 0.884 1.59 0.171 0.148 0.248 1.19 0.887 1.59 0.0987 0.151 0.514 1.1 0.82 1.49 ukb-melanoma-latest-gwas all 724.8 Other symptoms referable to back Musculoskeletal Both 0.928 0.719 1.2 0.562 63 630 FALSE 0.250263684430939 -0.0746 0.129 -0.0924 0.352 0.793 0.912 0.448 1.84 -0.172 0.356 0.629 0.842 0.409 1.71 -0.28 0.361 0.438 0.756 0.362 1.55 ukb-melanoma-latest-gwas all 724.9 Other unspecified back disorders Musculoskeletal Both 1 0.951 1.05 0.983 1616 16160 FALSE 0.00744648216786438 0.000574 0.0262 -0.0832 0.0737 0.259 0.92 0.796 1.06 -0.0467 0.0731 0.523 0.954 0.827 1.1 -0.0545 0.0737 0.459 0.947 0.819 1.09 ukb-melanoma-latest-gwas all 726 Peripheral enthesopathies and allied syndromes Musculoskeletal Both 1.02 1.01 1.04 0.00479 14821 148210 TRUE 2.31966448658544 0.0244 0.00865 0.0695 0.0246 0.0047 1.07 1.02 1.12 0.0691 0.0246 0.00502 1.07 1.02 1.12 0.071 0.0247 0.00405 1.07 1.02 1.13 ukb-melanoma-latest-gwas all 726.1 Enthesopathy Musculoskeletal Both 1.04 1.02 1.06 0.000494 9557 95570 TRUE 3.30627305107635 0.0376 0.0108 0.0518 0.0308 0.0924 1.05 0.992 1.12 0.0766 0.0307 0.0124 1.08 1.02 1.15 0.0962 0.0306 0.0017 1.1 1.04 1.17 ukb-melanoma-latest-gwas all 726.2 Synoviopathy Musculoskeletal Both 1.03 0.921 1.16 0.582 330 3300 FALSE 0.235077015350112 0.032 0.058 0.396 0.166 0.0172 1.49 1.07 2.07 0.358 0.169 0.034 1.43 1.03 2 0.124 0.177 0.483 1.13 0.799 1.61 ukb-melanoma-latest-gwas all 726.3 Bursitis Musculoskeletal Both 1.04 0.973 1.12 0.228 856 8560 FALSE 0.642065152999546 0.0433 0.0359 0.164 0.102 0.109 1.18 0.964 1.44 0.127 0.103 0.219 1.14 0.927 1.39 0.12 0.104 0.247 1.13 0.92 1.38 ukb-melanoma-latest-gwas all 727 Other disorders of synovium, tendon, and bursa Musculoskeletal Both 1 0.981 1.03 0.689 7593 75930 FALSE 0.161780778092374 0.00483 0.0121 0.00343 0.0342 0.92 1 0.938 1.07 0.0287 0.0341 0.4 1.03 0.963 1.1 0.0101 0.0343 0.769 1.01 0.944 1.08 ukb-melanoma-latest-gwas all 727.1 Synovitis and tenosynovitis Musculoskeletal Both 1.02 0.976 1.06 0.455 2738 27380 FALSE 0.341988603342888 0.015 0.0201 0.00144 0.0571 0.98 1 0.895 1.12 0.0529 0.0566 0.35 1.05 0.944 1.18 0.0104 0.0572 0.855 1.01 0.903 1.13 ukb-melanoma-latest-gwas all 727.2 Bursitis disorders Musculoskeletal Both 1.01 0.827 1.24 0.916 106 1060 FALSE 0.0381045263321496 0.0107 0.101 0.13 0.278 0.639 1.14 0.655 1.99 -0.215 0.302 0.476 0.807 0.438 1.47 0.147 0.277 0.595 1.16 0.669 2.02 ukb-melanoma-latest-gwas all 727.4 Ganglion and cyst of synovium, tendon, and bursa Musculoskeletal Both 0.979 0.944 1.02 0.255 3175 31750 FALSE 0.593459819566045 -0.0213 0.0187 -0.0383 0.052 0.462 0.962 0.869 1.07 -0.061 0.0524 0.244 0.941 0.849 1.04 -0.0826 0.0529 0.119 0.921 0.83 1.02 ukb-melanoma-latest-gwas all 727.5 Rupture of synovium Musculoskeletal Both 1.1 1.01 1.19 0.0346 587 5870 TRUE 1.46092390120722 0.0918 0.0435 0.13 0.129 0.316 1.14 0.883 1.47 0.314 0.125 0.012 1.37 1.07 1.75 0.32 0.126 0.0109 1.38 1.08 1.77 ukb-melanoma-latest-gwas all 727.6 Rupture of tendon, nontraumatic Musculoskeletal Both 1.03 0.922 1.15 0.606 352 3520 FALSE 0.217527375833714 0.0289 0.0559 0.0151 0.159 0.925 1.02 0.742 1.39 -0.0103 0.16 0.949 0.99 0.721 1.36 0.118 0.156 0.451 1.12 0.827 1.53 ukb-melanoma-latest-gwas all 727.7 Contracture of tendon (sheath) Musculoskeletal Both 1.06 0.894 1.26 0.488 142 1420 FALSE 0.311580177997289 0.061 0.0879 0.0248 0.25 0.921 1.03 0.624 1.69 -0.282 0.268 0.292 0.754 0.439 1.28 0.315 0.234 0.18 1.37 0.864 2.19 ukb-melanoma-latest-gwas all 728 Disorders of muscle, ligament, and fascia Musculoskeletal Both 1.04 1 1.07 0.0446 3697 36970 TRUE 1.35066514128786 0.0348 0.0173 0.00822 0.0493 0.868 1.01 0.915 1.11 0.0135 0.0493 0.785 1.01 0.92 1.12 0.0686 0.0488 0.16 1.07 0.973 1.18 ukb-melanoma-latest-gwas all 728.7 Fasciitis Musculoskeletal Both 1.04 1 1.07 0.0412 3482 34820 TRUE 1.38510278396687 0.0365 0.0179 0.0131 0.0507 0.796 1.01 0.917 1.12 0.0082 0.0509 0.872 1.01 0.913 1.11 0.0702 0.0503 0.163 1.07 0.972 1.18 ukb-melanoma-latest-gwas all 728.71 Contracture of palmar fascia [Dupuytren's disease] Musculoskeletal Both 1.04 1 1.07 0.0406 3482 34820 TRUE 1.39147396642281 0.0366 0.0179 0.0131 0.0507 0.796 1.01 0.917 1.12 0.0082 0.0509 0.872 1.01 0.913 1.11 0.0701 0.0503 0.163 1.07 0.972 1.18 ukb-melanoma-latest-gwas all 729 Other disorders of soft tissues Musculoskeletal Both 1.01 0.983 1.04 0.468 6051 60510 FALSE 0.329754146925876 0.00984 0.0135 0.0102 0.0381 0.789 1.01 0.937 1.09 -0.0298 0.0385 0.44 0.971 0.9 1.05 0.0296 0.0382 0.438 1.03 0.956 1.11 ukb-melanoma-latest-gwas all 729.1 Rheumatism, unspecified and fibrositis Musculoskeletal Both 1.04 0.971 1.11 0.28 1004 10040 FALSE 0.552841968657781 0.0358 0.0331 0.184 0.094 0.0503 1.2 1 1.45 0.0403 0.0971 0.678 1.04 0.86 1.26 0.166 0.0946 0.079 1.18 0.981 1.42 ukb-melanoma-latest-gwas all 731 Osteitis deformans and osteopathies associated with other disorders classified elsewhere Musculoskeletal Both 1.11 0.978 1.25 0.106 277 2770 FALSE 0.97469413473523 0.102 0.0632 -0.00687 0.18 0.97 0.993 0.696 1.42 -0.161 0.186 0.386 0.851 0.589 1.23 0.237 0.171 0.167 1.27 0.905 1.78 ukb-melanoma-latest-gwas all 731.1 Osteitis deformans [Paget's disease of bone] Musculoskeletal Both 1.11 0.974 1.26 0.118 262 2620 FALSE 0.928117992693875 0.102 0.0651 0.0525 0.184 0.775 1.05 0.733 1.52 -0.13 0.192 0.499 0.878 0.601 1.28 0.239 0.178 0.179 1.27 0.896 1.81 ukb-melanoma-latest-gwas all 732 Osteochondropathies Musculoskeletal Both 0.919 0.836 1.01 0.0804 472 4720 FALSE 1.09474395125155 -0.0846 0.0484 -0.131 0.13 0.317 0.878 0.679 1.13 -0.26 0.135 0.0542 0.771 0.591 1 -0.278 0.136 0.0408 0.757 0.579 0.988 ukb-melanoma-latest-gwas all 732.1 Juvenile osteochondrosis Musculoskeletal Both 0.936 0.811 1.08 0.36 207 2070 FALSE 0.443697499232713 -0.0665 0.0727 0.109 0.199 0.583 1.12 0.754 1.65 0.0227 0.202 0.91 1.02 0.686 1.53 -0.235 0.216 0.276 0.791 0.514 1.21 ukb-melanoma-latest-gwas all 732.7 Osteochondritis dissecans Musculoskeletal Both 0.844 0.642 1.1 0.212 59 590 FALSE 0.673664139071249 -0.17 0.136 -0.47 0.355 0.186 0.625 0.302 1.26 -0.369 0.354 0.297 0.691 0.336 1.39 -0.842 0.393 0.032 0.431 0.189 0.926 ukb-melanoma-latest-gwas all 733 Other disorders of bone and cartilage Musculoskeletal Both 1.02 0.971 1.07 0.438 1792 17920 FALSE 0.3585258894959 0.0193 0.0249 0.0946 0.0701 0.178 1.1 0.958 1.26 0.0507 0.0709 0.475 1.05 0.915 1.21 0.0491 0.0713 0.491 1.05 0.913 1.21 ukb-melanoma-latest-gwas all 733.2 Cyst of bone Musculoskeletal Both 1.01 0.904 1.14 0.804 319 3190 FALSE 0.0947439512515487 0.0146 0.0588 0.28 0.164 0.0877 1.32 0.959 1.83 0.178 0.169 0.291 1.19 0.858 1.67 0.0108 0.175 0.951 1.01 0.715 1.43 ukb-melanoma-latest-gwas all 735 Acquired foot deformities Musculoskeletal Both 1.01 0.989 1.03 0.342 9764 97640 FALSE 0.465973893943865 0.0101 0.0107 -0.0228 0.0303 0.452 0.977 0.921 1.04 0.0276 0.03 0.357 1.03 0.969 1.09 0.0135 0.0302 0.654 1.01 0.955 1.08 ukb-melanoma-latest-gwas all 735.1 Flat foot Musculoskeletal Both 1.02 0.882 1.19 0.747 190 1900 FALSE 0.126679398184601 0.0246 0.0763 -0.0471 0.219 0.829 0.954 0.618 1.47 0.142 0.21 0.499 1.15 0.762 1.75 0.0347 0.216 0.873 1.04 0.674 1.59 ukb-melanoma-latest-gwas all 735.2 Acquired toe deformities Musculoskeletal Both 1.01 0.982 1.04 0.478 5091 50910 FALSE 0.320572103387881 0.0105 0.0148 -0.003 0.042 0.943 0.997 0.918 1.08 0.0502 0.0415 0.226 1.05 0.969 1.14 0.014 0.042 0.738 1.01 0.934 1.1 ukb-melanoma-latest-gwas all 735.3 Hallux valgus (Bunion) Musculoskeletal Both 1.01 0.985 1.04 0.428 6639 66390 FALSE 0.368556230986828 0.0102 0.0129 -0.0704 0.0368 0.0556 0.932 0.867 1 0.00252 0.0362 0.945 1 0.934 1.08 0.00427 0.0363 0.906 1 0.935 1.08 ukb-melanoma-latest-gwas all 735.21 Hammer toe (acquired) Musculoskeletal Both 0.995 0.949 1.04 0.82 1914 19140 FALSE 0.0861861476162833 -0.00548 0.024 -0.103 0.0684 0.131 0.902 0.788 1.03 0.042 0.0663 0.527 1.04 0.916 1.19 -0.084 0.0683 0.218 0.919 0.804 1.05 ukb-melanoma-latest-gwas all 735.23 Hallux rigidus Musculoskeletal Both 1.03 0.974 1.08 0.335 1548 15480 FALSE 0.474955192963155 0.0258 0.0268 0.0969 0.0763 0.204 1.1 0.949 1.28 0.0915 0.0762 0.23 1.1 0.944 1.27 0.11 0.0767 0.152 1.12 0.96 1.3 ukb-melanoma-latest-gwas all 736 Other acquired deformities of limbs Musculoskeletal Both 1 0.952 1.05 0.945 1644 16440 FALSE 0.0245681914907371 0.0018 0.026 0.0555 0.0735 0.45 1.06 0.915 1.22 0.0428 0.0738 0.562 1.04 0.903 1.21 0.03 0.0741 0.685 1.03 0.891 1.19 ukb-melanoma-latest-gwas all 736.2 Acquired deformities of finger Musculoskeletal Both 1.08 0.947 1.23 0.25 248 2480 FALSE 0.602059991327962 0.0772 0.0671 0.0108 0.199 0.957 1.01 0.681 1.5 0.188 0.192 0.327 1.21 0.827 1.77 0.29 0.188 0.123 1.34 0.924 1.94 ukb-melanoma-latest-gwas all 737 Curvature of spine Musculoskeletal Both 1.01 0.954 1.08 0.645 1135 11350 FALSE 0.190440285364732 0.0144 0.0312 0.0858 0.0882 0.331 1.09 0.916 1.3 0.0744 0.0885 0.4 1.08 0.906 1.28 0.0282 0.0899 0.754 1.03 0.862 1.23 ukb-melanoma-latest-gwas all 737.3 Kyphoscoliosis and scoliosis Musculoskeletal Both 1.01 0.951 1.08 0.675 1064 10640 FALSE 0.170696227168975 0.0135 0.0323 0.0423 0.091 0.642 1.04 0.873 1.25 0.042 0.0911 0.645 1.04 0.872 1.25 0.0159 0.0922 0.863 1.02 0.848 1.22 ukb-melanoma-latest-gwas all 738 Other acquired musculoskeletal deformity Musculoskeletal Both 1.02 0.976 1.07 0.34 1921 19210 FALSE 0.468521082957745 0.0229 0.024 -0.0568 0.0683 0.406 0.945 0.826 1.08 0.0127 0.0675 0.851 1.01 0.887 1.16 0.018 0.0675 0.79 1.02 0.892 1.16 ukb-melanoma-latest-gwas all 738.4 Acquired spondylolisthesis Musculoskeletal Both 1.04 0.989 1.1 0.124 1520 15200 FALSE 0.906578314837765 0.0416 0.027 -0.00869 0.077 0.91 0.991 0.852 1.15 0.0178 0.077 0.817 1.02 0.875 1.18 0.0977 0.0756 0.197 1.1 0.951 1.28 ukb-melanoma-latest-gwas all 739 Contracture of joint Musculoskeletal Both 1.03 0.938 1.13 0.534 489 4890 FALSE 0.272458742971444 0.0295 0.0475 -0.109 0.137 0.425 0.897 0.685 1.17 0.0812 0.132 0.539 1.08 0.837 1.41 0.0359 0.133 0.787 1.04 0.798 1.35 ukb-melanoma-latest-gwas all 740 Osteoarthrosis Musculoskeletal Both 1.01 0.999 1.02 0.0791 27860 232406 FALSE 1.10182351650232 0.0112 0.00638 0.00967 0.0181 0.592 1.01 0.975 1.05 0.0128 0.0181 0.478 1.01 0.978 1.05 0.0296 0.0181 0.101 1.03 0.994 1.07 ukb-melanoma-latest-gwas all 740.1 Osteoarthritis; localized Musculoskeletal Both 1.01 0.994 1.03 0.248 17461 169819 FALSE 0.605548319173784 0.00922 0.00798 -0.00584 0.0225 0.796 0.994 0.951 1.04 -0.0179 0.0226 0.429 0.982 0.94 1.03 0.0319 0.0225 0.156 1.03 0.988 1.08 ukb-melanoma-latest-gwas all 740.2 Osteoarthrosis, generalized Musculoskeletal Both 1.1 1.01 1.19 0.0307 599 5990 TRUE 1.51286162452281 0.0929 0.043 0.00326 0.122 0.979 1 0.789 1.28 -0.124 0.126 0.323 0.883 0.689 1.13 0.19 0.118 0.106 1.21 0.96 1.53 ukb-melanoma-latest-gwas all 740.9 Osteoarthrosis NOS Musculoskeletal Both 1.02 0.999 1.04 0.0618 12302 123014 FALSE 1.20901152491118 0.0177 0.0095 0.0477 0.0269 0.0767 1.05 0.995 1.11 0.049 0.027 0.0692 1.05 0.996 1.11 0.0456 0.0271 0.0923 1.05 0.993 1.1 ukb-melanoma-latest-gwas all 740.11 Osteoarthrosis, localized, primary Musculoskeletal Both 1 0.983 1.03 0.663 8997 89952 FALSE 0.178486471595227 0.00484 0.0111 0.0172 0.0313 0.584 1.02 0.957 1.08 0.00179 0.0315 0.955 1 0.942 1.07 0.027 0.0314 0.391 1.03 0.966 1.09 ukb-melanoma-latest-gwas all 740.12 Osteoarthrosis, localized, secondary Musculoskeletal Both 1.01 0.901 1.12 0.913 348 3480 FALSE 0.039529222465701 0.00612 0.0563 0.096 0.154 0.534 1.1 0.812 1.49 -0.0954 0.161 0.555 0.909 0.661 1.25 -0.0395 0.159 0.804 0.961 0.702 1.32 ukb-melanoma-latest-gwas all 741 Symptoms and disorders of the joints Musculoskeletal Both 1 0.97 1.04 0.83 3624 36240 FALSE 0.0809219076239261 0.00377 0.0175 -0.00161 0.0494 0.974 0.998 0.906 1.1 -0.0079 0.0496 0.873 0.992 0.9 1.09 0.0192 0.0495 0.697 1.02 0.925 1.12 ukb-melanoma-latest-gwas all 741.1 Ankylosis of joint Musculoskeletal Both 1.02 0.833 1.26 0.836 102 1020 FALSE 0.0777937225609836 0.0214 0.104 -0.995 0.336 0.00311 0.37 0.182 0.708 -0.222 0.272 0.416 0.801 0.464 1.37 -0.07 0.266 0.792 0.932 0.55 1.58 ukb-melanoma-latest-gwas all 741.2 Stiffness of joint Musculoskeletal Both 0.929 0.854 1.01 0.0832 614 6140 FALSE 1.07987667370928 -0.0738 0.0426 -0.0277 0.115 0.81 0.973 0.776 1.22 -0.273 0.122 0.0256 0.761 0.598 0.967 -0.146 0.119 0.22 0.864 0.684 1.09 ukb-melanoma-latest-gwas all 741.3 Difficulty in walking Musculoskeletal Both 1.11 0.942 1.31 0.207 155 1550 FALSE 0.684029654543082 0.106 0.0837 0.0867 0.245 0.723 1.09 0.672 1.78 0.249 0.235 0.29 1.28 0.807 2.06 0.144 0.243 0.554 1.15 0.714 1.87 ukb-melanoma-latest-gwas all 741.4 Joint effusions Musculoskeletal Both 0.981 0.929 1.04 0.493 1420 14200 FALSE 0.30715308072277 -0.0191 0.0279 -0.0485 0.0781 0.534 0.953 0.817 1.11 -0.103 0.0792 0.193 0.902 0.772 1.05 -0.0326 0.0782 0.677 0.968 0.83 1.13 ukb-melanoma-latest-gwas all 741.5 Hemarthrosis Musculoskeletal Both 0.945 0.778 1.15 0.567 111 1110 FALSE 0.246416941107093 -0.0564 0.0985 -0.189 0.287 0.51 0.827 0.464 1.46 0.162 0.265 0.542 1.18 0.695 2 -0.0186 0.277 0.947 0.982 0.564 1.71 ukb-melanoma-latest-gwas all 741.6 Villonodular synovitis Musculoskeletal Both 1.24 0.932 1.65 0.137 54 540 FALSE 0.863279432843593 0.212 0.142 -0.187 0.457 0.682 0.829 0.315 2.13 0.457 0.412 0.267 1.58 0.696 3.72 0.727 0.387 0.0601 2.07 0.974 4.65 ukb-melanoma-latest-gwas all 742 Derangement of joint, non-traumatic Musculoskeletal Both 1.01 0.97 1.05 0.671 2906 29060 FALSE 0.173277479831008 0.00831 0.0196 -0.0599 0.0552 0.278 0.942 0.845 1.05 -0.0556 0.0553 0.314 0.946 0.849 1.05 0.00488 0.0546 0.929 1 0.903 1.12 ukb-melanoma-latest-gwas all 742.1 Loose body in joint Musculoskeletal Both 0.93 0.83 1.04 0.211 332 3320 FALSE 0.675717544702307 -0.0723 0.0578 -0.116 0.158 0.464 0.891 0.651 1.22 -0.109 0.159 0.493 0.897 0.655 1.23 -0.275 0.165 0.0958 0.76 0.547 1.05 ukb-melanoma-latest-gwas all 742.2 Pathological, developmental or recurrent dislocation Musculoskeletal Both 0.923 0.746 1.14 0.45 96 960 FALSE 0.346787486224656 -0.0805 0.107 0.209 0.284 0.461 1.23 0.704 2.18 -0.104 0.304 0.732 0.901 0.49 1.65 -0.185 0.315 0.557 0.831 0.439 1.56 ukb-melanoma-latest-gwas all 742.8 Articular cartilage disorder Musculoskeletal Both 0.948 0.864 1.04 0.251 499 4990 FALSE 0.600326278518962 -0.0538 0.0468 -0.0235 0.128 0.855 0.977 0.759 1.26 -0.251 0.135 0.0638 0.778 0.595 1.01 -0.0762 0.13 0.558 0.927 0.717 1.2 ukb-melanoma-latest-gwas all 742.9 Other derangement of joint Musculoskeletal Both 1.03 0.987 1.08 0.162 1995 19950 FALSE 0.790484985457369 0.033 0.0236 -0.0638 0.0674 0.344 0.938 0.822 1.07 -0.028 0.067 0.676 0.972 0.853 1.11 0.0702 0.0656 0.285 1.07 0.943 1.22 ukb-melanoma-latest-gwas all 743 Osteoporosis, osteopenia and pathological fracture Musculoskeletal Both 1.01 0.99 1.04 0.245 7628 76256 FALSE 0.610833915635468 0.014 0.0121 -0.0562 0.0343 0.101 0.945 0.884 1.01 -0.0159 0.034 0.64 0.984 0.921 1.05 0.0184 0.0338 0.586 1.02 0.953 1.09 ukb-melanoma-latest-gwas all 743.1 Osteoporosis Musculoskeletal Both 1.02 0.995 1.05 0.119 6434 64335 FALSE 0.924453038607469 0.0205 0.0131 -0.0408 0.0374 0.275 0.96 0.892 1.03 -0.00815 0.0371 0.826 0.992 0.922 1.07 0.0415 0.0368 0.259 1.04 0.97 1.12 ukb-melanoma-latest-gwas all 743.2 Pathologic fracture Musculoskeletal Both 1.02 0.934 1.12 0.633 523 5230 FALSE 0.198596289982645 0.022 0.0461 -0.105 0.129 0.418 0.9 0.698 1.16 -0.0731 0.129 0.57 0.93 0.721 1.2 -0.0439 0.128 0.732 0.957 0.744 1.23 ukb-melanoma-latest-gwas all 743.9 Osteopenia or other disorder of bone and cartilage Musculoskeletal Both 0.975 0.907 1.05 0.492 819 8190 FALSE 0.30803489723264 -0.0252 0.0367 -0.117 0.102 0.251 0.889 0.727 1.09 -0.132 0.102 0.197 0.876 0.716 1.07 -0.118 0.102 0.249 0.889 0.727 1.09 ukb-melanoma-latest-gwas all 743.11 Osteoporosis NOS Musculoskeletal Both 1.01 0.985 1.04 0.356 5577 55767 FALSE 0.448550002027125 0.013 0.0141 -0.0739 0.0401 0.0654 0.929 0.858 1 -0.0108 0.0396 0.785 0.989 0.915 1.07 0.0137 0.0395 0.729 1.01 0.938 1.1 ukb-melanoma-latest-gwas all 743.13 Other specified osteoporosis Musculoskeletal Both 1 0.916 1.1 0.975 530 5299 FALSE 0.0109953843014632 0.00143 0.0456 -0.0372 0.128 0.772 0.963 0.749 1.24 -0.0814 0.129 0.529 0.922 0.714 1.19 -0.00774 0.127 0.952 0.992 0.772 1.27 ukb-melanoma-latest-gwas all 745 Pain in joint Musculoskeletal Both 1.02 0.994 1.04 0.148 7994 79930 FALSE 0.829738284605043 0.0171 0.0118 -0.00143 0.0334 0.966 0.999 0.935 1.07 -0.000922 0.0335 0.978 0.999 0.936 1.07 0.0576 0.0332 0.082 1.06 0.993 1.13 ukb-melanoma-latest-gwas all 747 Cardiac and circulatory congenital anomalies Congenital Anomalies Both 0.976 0.939 1.01 0.223 2822 28217 FALSE 0.651695136951839 -0.0242 0.0198 -0.0762 0.0556 0.171 0.927 0.831 1.03 -0.0321 0.0551 0.56 0.968 0.869 1.08 -0.0898 0.0561 0.109 0.914 0.819 1.02 ukb-melanoma-latest-gwas all 747.1 Cardiac congenital anomalies Congenital Anomalies Both 0.97 0.932 1.01 0.131 2645 26447 FALSE 0.882728704344236 -0.0309 0.0205 -0.0795 0.0571 0.164 0.924 0.826 1.03 -0.0747 0.0571 0.191 0.928 0.83 1.04 -0.098 0.0577 0.0894 0.907 0.81 1.02 ukb-melanoma-latest-gwas all 747.2 Congenital anomalies of peripheral vascular system Congenital Anomalies Both 1.02 0.868 1.2 0.821 167 1670 FALSE 0.0856568428805593 0.0184 0.0813 -0.139 0.243 0.566 0.87 0.535 1.41 0.43 0.217 0.0472 1.54 1.01 2.37 -0.0704 0.241 0.77 0.932 0.577 1.5 ukb-melanoma-latest-gwas all 747.11 Cardiac shunt/ heart septal defect Congenital Anomalies Both 0.93 0.854 1.01 0.0935 587 5870 FALSE 1.02918838912748 -0.0726 0.0433 -0.14 0.118 0.237 0.869 0.688 1.1 -0.291 0.123 0.0182 0.748 0.586 0.951 -0.134 0.119 0.262 0.875 0.692 1.11 ukb-melanoma-latest-gwas all 747.12 Valvular heart disease/ heart chambers Congenital Anomalies Both 0.929 0.812 1.06 0.281 236 2360 FALSE 0.55129368009492 -0.0735 0.0682 -0.131 0.187 0.484 0.877 0.605 1.27 -0.0771 0.184 0.676 0.926 0.643 1.33 -0.347 0.197 0.0789 0.707 0.477 1.04 ukb-melanoma-latest-gwas all 747.13 Congenital anomalies of great vessels Congenital Anomalies Both 0.966 0.921 1.01 0.162 1823 18227 FALSE 0.790484985457369 -0.0344 0.0246 -0.0767 0.0685 0.263 0.926 0.81 1.06 -0.0718 0.0685 0.295 0.931 0.814 1.06 -0.131 0.0697 0.0613 0.878 0.765 1.01 ukb-melanoma-latest-gwas all 748 Anomalies of respiratory system, congenital Congenital Anomalies Both 1.03 0.772 1.37 0.838 51 510 FALSE 0.0767559813697235 0.0294 0.143 -0.155 0.427 0.716 0.856 0.354 2.04 0.473 0.384 0.218 1.6 0.752 3.54 -0.0531 0.417 0.899 0.948 0.404 2.21 ukb-melanoma-latest-gwas all 749 Congenital anomalies of face and neck Congenital Anomalies Both 0.96 0.856 1.08 0.479 324 3240 FALSE 0.319664486585437 -0.0412 0.0583 -0.283 0.163 0.0824 0.754 0.546 1.04 -0.206 0.16 0.198 0.814 0.593 1.11 -0.208 0.161 0.195 0.812 0.591 1.11 ukb-melanoma-latest-gwas all 750 Digestive congenital anomalies Congenital Anomalies Both 1.11 1.02 1.2 0.0106 704 7040 TRUE 1.97469413473523 0.102 0.0399 0.0672 0.117 0.565 1.07 0.85 1.35 0.148 0.115 0.199 1.16 0.925 1.45 0.287 0.112 0.0106 1.33 1.07 1.66 ukb-melanoma-latest-gwas all 750.1 Upper gastrointestinal congenital anomalies Congenital Anomalies Both 1.12 0.996 1.25 0.0572 336 3360 FALSE 1.24260397120698 0.109 0.0574 0.0415 0.17 0.807 1.04 0.745 1.46 0.197 0.165 0.233 1.22 0.88 1.69 0.312 0.162 0.054 1.37 0.995 1.88 ukb-melanoma-latest-gwas all 750.2 Lower gastrointestinal congenital anomalies Congenital Anomalies Both 1.1 0.989 1.23 0.0781 364 3640 FALSE 1.1073489661227 0.0978 0.0555 0.0337 0.161 0.835 1.03 0.752 1.42 0.131 0.159 0.408 1.14 0.834 1.56 0.247 0.156 0.113 1.28 0.943 1.74 ukb-melanoma-latest-gwas all 750.13 Congenital anomalies of mouth/tongue Congenital Anomalies Both 1.01 0.87 1.17 0.908 193 1930 FALSE 0.0419141514789149 0.00873 0.0754 -0.203 0.219 0.354 0.816 0.527 1.26 0.11 0.205 0.592 1.12 0.745 1.68 -0.0101 0.211 0.962 0.99 0.652 1.5 ukb-melanoma-latest-gwas all 750.21 Congenital anomalies of intestine Congenital Anomalies Both 1.02 0.891 1.17 0.768 229 2290 FALSE 0.114638779968488 0.0205 0.0694 -0.0143 0.192 0.94 0.986 0.675 1.44 -0.238 0.203 0.242 0.788 0.526 1.18 0.0649 0.19 0.732 1.07 0.734 1.55 ukb-melanoma-latest-gwas all 750.22 Congenital anomaly of gallbladder, bile ducts, liver, pancreas Congenital Anomalies Both 1.27 1.05 1.54 0.0145 118 1180 TRUE 1.83863199776503 0.239 0.098 -0.0635 0.316 0.841 0.938 0.494 1.77 0.735 0.273 0.00706 2.08 1.23 3.64 0.453 0.288 0.116 1.57 0.893 2.82 ukb-melanoma-latest-gwas all 751 Genitourinary congenital anomalies Congenital Anomalies Both 1.02 0.971 1.08 0.398 1590 15900 FALSE 0.400116927926312 0.0223 0.0264 0.0811 0.0748 0.278 1.08 0.937 1.26 0.0606 0.0753 0.421 1.06 0.917 1.23 0.0583 0.0755 0.44 1.06 0.914 1.23 ukb-melanoma-latest-gwas all 751.1 Congenital anomalies of genital organs Congenital Anomalies Both 1.01 0.936 1.09 0.792 731 7310 FALSE 0.101274818410506 0.0103 0.0389 0.0973 0.109 0.372 1.1 0.89 1.37 0.00917 0.111 0.934 1.01 0.811 1.26 0.0322 0.111 0.772 1.03 0.83 1.29 ukb-melanoma-latest-gwas all 751.2 Congenital anomalies of urinary system Congenital Anomalies Both 1.02 0.952 1.1 0.547 850 8500 FALSE 0.262012673666569 0.0217 0.0361 0.0537 0.103 0.601 1.06 0.862 1.29 0.103 0.102 0.315 1.11 0.907 1.35 0.0471 0.103 0.648 1.05 0.856 1.28 ukb-melanoma-latest-gwas all 751.11 Congenital anomalies of female genital organs Congenital Anomalies Female 1.02 0.925 1.12 0.712 457 4570 FALSE 0.147520006363144 0.0182 0.0492 0.217 0.139 0.117 1.24 0.947 1.63 0.107 0.142 0.453 1.11 0.841 1.47 0.1 0.143 0.483 1.11 0.835 1.47 ukb-melanoma-latest-gwas all 751.12 Congenital anomalies of male genital organs Congenital Anomalies Male 1.04 0.908 1.19 0.57 228 2280 FALSE 0.244125144327509 0.0395 0.0694 -0.211 0.196 0.281 0.81 0.548 1.19 -0.176 0.194 0.364 0.839 0.571 1.23 -0.00847 0.189 0.964 0.992 0.683 1.44 ukb-melanoma-latest-gwas all 751.21 Cystic kidney disease Congenital Anomalies Both 1.09 0.988 1.21 0.0849 426 4260 FALSE 1.07109230975605 0.0878 0.051 0.215 0.148 0.146 1.24 0.927 1.66 0.238 0.147 0.107 1.27 0.95 1.7 0.218 0.148 0.142 1.24 0.929 1.67 ukb-melanoma-latest-gwas all 751.22 Other specified congenital anomalies of kidney Congenital Anomalies Both 0.979 0.875 1.1 0.711 339 3390 FALSE 0.148130399270234 -0.0211 0.0569 -0.134 0.161 0.406 0.875 0.636 1.2 -0.0215 0.159 0.892 0.979 0.716 1.34 -0.0493 0.158 0.755 0.952 0.696 1.3 ukb-melanoma-latest-gwas all 752 Nervous system congenital anomalies Congenital Anomalies Both 0.999 0.893 1.12 0.991 336 3360 FALSE 0.00392634551472468 -0.000622 0.0571 0.233 0.159 0.144 1.26 0.924 1.73 0.136 0.162 0.401 1.15 0.833 1.58 -0.0548 0.17 0.747 0.947 0.676 1.32 ukb-melanoma-latest-gwas all 752.1 Neural tube defects Congenital Anomalies Both 1.01 0.884 1.14 0.938 257 2570 FALSE 0.0277971616209356 0.0051 0.0652 0.218 0.179 0.225 1.24 0.874 1.77 -0.00597 0.188 0.975 0.994 0.686 1.44 -0.0369 0.19 0.846 0.964 0.662 1.4 ukb-melanoma-latest-gwas all 752.2 Other specified congenital anomalies of nervous system Congenital Anomalies Both 0.995 0.793 1.25 0.966 80 800 FALSE 0.0150228735845067 -0.0049 0.116 -0.151 0.334 0.651 0.86 0.436 1.68 0.307 0.306 0.316 1.36 0.744 2.52 -0.221 0.341 0.518 0.802 0.4 1.58 ukb-melanoma-latest-gwas all 752.11 Spina bifida Congenital Anomalies Both 1.06 0.924 1.23 0.387 211 2110 FALSE 0.412289034981089 0.0624 0.0721 0.311 0.203 0.126 1.36 0.916 2.05 0.126 0.211 0.551 1.13 0.748 1.72 0.156 0.21 0.459 1.17 0.772 1.78 ukb-melanoma-latest-gwas all 753 Congenital anomalies of the eye Congenital Anomalies Both 0.821 0.687 0.983 0.03 131 1310 TRUE 1.52287874528034 -0.197 0.0906 -0.19 0.249 0.445 0.827 0.502 1.35 -0.0129 0.238 0.957 0.987 0.615 1.58 -0.516 0.27 0.0554 0.597 0.345 1.01 ukb-melanoma-latest-gwas all 753.1 Congenital cataract and lens anomalies Congenital Anomalies Both 0.872 0.691 1.1 0.245 76 760 FALSE 0.610833915635468 -0.137 0.118 -0.631 0.355 0.0759 0.532 0.253 1.07 0.00453 0.3 0.988 1 0.552 1.83 -0.431 0.332 0.194 0.65 0.33 1.25 ukb-melanoma-latest-gwas all 754 Congenital musculoskeletal deformities of spine Congenital Anomalies Both 0.923 0.757 1.12 0.425 110 1100 FALSE 0.371611069949688 -0.0799 0.1 0.275 0.266 0.302 1.32 0.779 2.25 0.0209 0.276 0.94 1.02 0.589 1.77 -0.393 0.307 0.2 0.675 0.361 1.24 ukb-melanoma-latest-gwas all 755 Congenital anomalies of limbs Congenital Anomalies Both 1.02 0.921 1.12 0.753 449 4490 FALSE 0.123205023799299 0.0156 0.0496 0.252 0.139 0.0702 1.29 0.979 1.69 0.0759 0.144 0.598 1.08 0.813 1.43 0.107 0.144 0.459 1.11 0.838 1.48 ukb-melanoma-latest-gwas all 755.1 Congenital deformities of feet Congenital Anomalies Both 1.06 0.923 1.23 0.386 210 2100 FALSE 0.413412695328245 0.063 0.0726 0.344 0.208 0.0982 1.41 0.938 2.14 0.287 0.211 0.175 1.33 0.879 2.03 0.207 0.217 0.34 1.23 0.802 1.9 ukb-melanoma-latest-gwas all 755.6 Other congenital anomalies of lower limb, including pelvic girdle Congenital Anomalies Both 0.957 0.814 1.13 0.591 162 1620 FALSE 0.228412519118745 -0.044 0.082 0.155 0.223 0.486 1.17 0.753 1.82 -0.197 0.241 0.414 0.821 0.506 1.32 0.0546 0.23 0.813 1.06 0.669 1.67 ukb-melanoma-latest-gwas all 755.61 Congenital hip dysplasia and deformity Congenital Anomalies Both 0.919 0.754 1.12 0.401 107 1070 FALSE 0.396855627379818 -0.0841 0.1 0.0173 0.262 0.947 1.02 0.605 1.71 -0.627 0.313 0.0447 0.534 0.28 0.984 -0.0871 0.271 0.748 0.917 0.533 1.57 ukb-melanoma-latest-gwas all 756 Other congenital musculoskeletal anomalies Congenital Anomalies Both 1.03 0.947 1.12 0.482 593 5930 FALSE 0.31695296176115 0.0304 0.0432 0.246 0.125 0.049 1.28 1 1.64 0.283 0.124 0.0223 1.33 1.04 1.7 0.159 0.128 0.214 1.17 0.912 1.51 ukb-melanoma-latest-gwas all 756.3 Congenital anomalies of muscle, tendon, fascia, and connective tissue Congenital Anomalies Both 1.12 0.89 1.41 0.33 81 810 FALSE 0.481486060122112 0.113 0.116 -0.00491 0.335 0.988 0.995 0.506 1.96 0.308 0.319 0.334 1.36 0.726 2.6 0.0493 0.336 0.883 1.05 0.535 2.07 ukb-melanoma-latest-gwas all 756.5 Congenital osteodystrophies Congenital Anomalies Both 1 0.907 1.11 0.981 436 4360 FALSE 0.0083309926200515 0.00122 0.0503 0.283 0.144 0.0484 1.33 1 1.76 0.218 0.146 0.135 1.24 0.934 1.66 0.149 0.149 0.316 1.16 0.867 1.56 ukb-melanoma-latest-gwas all 758 Chromosomal anomalies and genetic disorders Congenital Anomalies Both 1.02 0.879 1.19 0.784 189 1890 FALSE 0.105683937315562 0.0208 0.0759 -0.0304 0.216 0.888 0.97 0.632 1.49 -0.039 0.214 0.855 0.962 0.629 1.47 0.0502 0.21 0.811 1.05 0.694 1.59 ukb-melanoma-latest-gwas all 758.1 Chromosomal anomalies Congenital Anomalies Both 0.949 0.775 1.17 0.608 100 1000 FALSE 0.216096420727265 -0.0528 0.103 -0.0271 0.278 0.922 0.973 0.559 1.69 -0.368 0.297 0.215 0.692 0.379 1.24 -0.155 0.285 0.587 0.856 0.483 1.51 ukb-melanoma-latest-gwas all 759 Other and unspecified congenital anomalies Congenital Anomalies Both 1.06 0.927 1.22 0.385 233 2330 FALSE 0.414539270491499 0.0598 0.0689 0.0556 0.204 0.785 1.06 0.707 1.58 0.183 0.198 0.356 1.2 0.813 1.78 0.349 0.195 0.0737 1.42 0.967 2.09 ukb-melanoma-latest-gwas all 759.1 Anomalies of endocrine glands, congenital Congenital Anomalies Both 0.99 0.81 1.21 0.923 105 1050 FALSE 0.0347982989740879 -0.00982 0.102 -0.324 0.293 0.268 0.723 0.399 1.29 -0.134 0.283 0.636 0.875 0.496 1.54 0.0424 0.277 0.878 1.04 0.601 1.81 ukb-melanoma-latest-gwas all 760 Back pain Symptoms Both 1.01 0.992 1.03 0.257 11163 111617 FALSE 0.590066876668705 0.0113 0.00997 -0.0134 0.0282 0.633 0.987 0.934 1.04 -0.00383 0.0282 0.892 0.996 0.943 1.05 0.0114 0.0282 0.685 1.01 0.957 1.07 ukb-melanoma-latest-gwas all 761 Cervicalgia Symptoms Both 1.01 0.965 1.06 0.596 1792 17920 FALSE 0.224753740259764 0.0132 0.0249 0.0918 0.0702 0.191 1.1 0.955 1.26 -0.017 0.0719 0.813 0.983 0.854 1.13 0.112 0.0703 0.11 1.12 0.975 1.28 ukb-melanoma-latest-gwas all 764 Sciatica Symptoms Both 0.987 0.946 1.03 0.531 2378 23780 FALSE 0.274905478918531 -0.0135 0.0216 0.016 0.0609 0.793 1.02 0.902 1.14 0.0323 0.0607 0.594 1.03 0.917 1.16 -0.0173 0.0616 0.779 0.983 0.871 1.11 ukb-melanoma-latest-gwas all 766 Neuralgia, neuritis, and radiculitis NOS Symptoms Both 0.963 0.907 1.02 0.215 1182 11820 FALSE 0.667561540084395 -0.0379 0.0306 -0.103 0.085 0.226 0.902 0.763 1.07 -0.0478 0.084 0.57 0.953 0.808 1.12 -0.187 0.0874 0.0325 0.83 0.699 0.985 ukb-melanoma-latest-gwas all 770 Myalgia and myositis unspecified Symptoms Both 1.06 0.979 1.15 0.147 642 6420 FALSE 0.832682665251824 0.0604 0.0416 0.0328 0.12 0.785 1.03 0.815 1.31 0.067 0.12 0.576 1.07 0.845 1.35 0.222 0.116 0.0564 1.25 0.994 1.57 ukb-melanoma-latest-gwas all 771 Musculoskeletal symptoms referable to limbs Symptoms Both 0.978 0.913 1.05 0.539 874 8732 FALSE 0.268411234813261 -0.0219 0.0355 0.162 0.101 0.109 1.18 0.965 1.43 0.185 0.1 0.0654 1.2 0.988 1.47 -0.00484 0.105 0.963 0.995 0.81 1.22 ukb-melanoma-latest-gwas all 772 Symptoms of the muscles Symptoms Both 1.05 0.967 1.13 0.258 676 6760 FALSE 0.58838029403677 0.0459 0.0406 -0.00334 0.116 0.977 0.997 0.794 1.25 0.0851 0.114 0.455 1.09 0.871 1.36 0.0581 0.115 0.615 1.06 0.845 1.33 ukb-melanoma-latest-gwas all 773 Pain in limb Symptoms Both 1 0.976 1.03 0.916 6290 62896 FALSE 0.0381045263321496 0.0014 0.0133 -0.0197 0.0374 0.599 0.981 0.911 1.06 -0.0417 0.0377 0.268 0.959 0.891 1.03 0.0157 0.0373 0.673 1.02 0.944 1.09 ukb-melanoma-latest-gwas all 780 Hypothermia/Chills Symptoms Both 0.964 0.823 1.13 0.643 172 1720 FALSE 0.191789027075778 -0.037 0.0798 0.259 0.218 0.234 1.3 0.844 2 -0.0345 0.233 0.882 0.966 0.607 1.53 0.00358 0.23 0.988 1 0.636 1.59 ukb-melanoma-latest-gwas all 781 Symptoms involving nervous and musculoskeletal systems Symptoms Both 1.01 0.961 1.06 0.733 1880 18800 FALSE 0.134896025358872 0.00827 0.0243 0.0362 0.0687 0.599 1.04 0.906 1.19 0.0168 0.0691 0.808 1.02 0.888 1.16 0.0564 0.0686 0.411 1.06 0.925 1.21 ukb-melanoma-latest-gwas all 783 Fever of unknown origin Symptoms Both 1.01 0.982 1.05 0.382 3930 39300 FALSE 0.417936637088291 0.0147 0.0168 0.0183 0.0475 0.701 1.02 0.928 1.12 0.0511 0.0473 0.28 1.05 0.959 1.15 0.00535 0.0479 0.911 1.01 0.915 1.1 ukb-melanoma-latest-gwas all 785 Abdominal pain Symptoms Both 1.01 0.999 1.02 0.0712 40170 302301 FALSE 1.14752000636314 0.00964 0.00535 0.00712 0.0151 0.638 1.01 0.978 1.04 0.00582 0.0152 0.701 1.01 0.976 1.04 0.0202 0.0151 0.182 1.02 0.991 1.05 ukb-melanoma-latest-gwas all 788 Syncope and collapse Symptoms Both 1.01 0.988 1.03 0.406 9112 91099 FALSE 0.391473966422806 0.00917 0.011 -0.0233 0.0314 0.458 0.977 0.919 1.04 0.026 0.0311 0.403 1.03 0.966 1.09 0.0297 0.0311 0.341 1.03 0.969 1.09 ukb-melanoma-latest-gwas all 789 Nausea and vomiting Symptoms Both 1.01 0.987 1.03 0.513 11612 116110 FALSE 0.289882634888184 0.00641 0.00978 0.00339 0.0277 0.903 1 0.95 1.06 0.035 0.0275 0.203 1.04 0.981 1.09 -0.00679 0.0279 0.808 0.993 0.94 1.05 ukb-melanoma-latest-gwas all 790 Nonspecific findings on examination of blood Symptoms Both 0.972 0.822 1.15 0.74 150 1500 FALSE 0.130768280269024 -0.0282 0.0851 -0.0496 0.238 0.835 0.952 0.592 1.53 -0.0897 0.24 0.709 0.914 0.566 1.47 -0.0584 0.236 0.804 0.943 0.59 1.51 ukb-melanoma-latest-gwas all 791 Gangrene Symptoms Both 0.919 0.842 1 0.0598 553 5530 FALSE 1.22329881601159 -0.0841 0.0447 -0.0684 0.123 0.579 0.934 0.733 1.19 -0.031 0.123 0.8 0.969 0.762 1.23 -0.232 0.129 0.0718 0.793 0.614 1.02 ukb-melanoma-latest-gwas all 792 Abnormal Papanicolaou smear of cervix and cervical HPV Symptoms Female 1.17 0.952 1.44 0.129 98 966 FALSE 0.889410289700751 0.159 0.105 0.154 0.311 0.621 1.17 0.627 2.18 0.0798 0.313 0.799 1.08 0.58 2.03 0.371 0.297 0.212 1.45 0.808 2.65 ukb-melanoma-latest-gwas all 793 Nonspecific abnormal findings on radiological and other examination of musculoskeletal system Symptoms Both 0.968 0.809 1.16 0.715 134 1340 FALSE 0.145693958198919 -0.0329 0.0901 -0.0746 0.247 0.762 0.928 0.568 1.51 -0.247 0.258 0.338 0.781 0.466 1.3 -0.104 0.25 0.679 0.902 0.547 1.48 ukb-melanoma-latest-gwas all 794 Abnormal results of other function studies (bladder, pancreas, placenta, spleen, etc) Symptoms Both 0.976 0.809 1.18 0.8 120 1200 FALSE 0.0969100130080564 -0.024 0.0947 0.38 0.254 0.135 1.46 0.889 2.44 -0.101 0.279 0.718 0.904 0.515 1.58 -0.106 0.28 0.705 0.899 0.512 1.57 ukb-melanoma-latest-gwas all 797 Shock Symptoms Both 0.94 0.796 1.11 0.464 156 1560 FALSE 0.333482019445119 -0.0615 0.084 0.215 0.226 0.341 1.24 0.795 1.95 -0.0709 0.241 0.769 0.932 0.576 1.5 -0.176 0.248 0.478 0.839 0.511 1.37 ukb-melanoma-latest-gwas all 797.1 Cardiogenic shock Symptoms Both 0.915 0.745 1.12 0.392 102 1020 FALSE 0.406713932979543 -0.0886 0.104 0.141 0.276 0.61 1.15 0.666 2 -0.145 0.295 0.622 0.865 0.478 1.56 -0.24 0.299 0.422 0.786 0.429 1.43 ukb-melanoma-latest-gwas all 798 Malaise and fatigue Symptoms Both 1.01 0.97 1.04 0.775 3424 34226 FALSE 0.11069829749369 0.00516 0.018 -0.0931 0.0512 0.0689 0.911 0.824 1.01 -0.0124 0.0503 0.806 0.988 0.895 1.09 -0.0096 0.0505 0.849 0.99 0.897 1.09 ukb-melanoma-latest-gwas all 798.1 Chronic fatigue syndrome Symptoms Both 0.984 0.904 1.07 0.703 590 5900 FALSE 0.153044674980176 -0.0165 0.0432 -0.0801 0.12 0.506 0.923 0.728 1.17 -0.141 0.122 0.249 0.868 0.682 1.1 -0.0448 0.12 0.709 0.956 0.755 1.21 ukb-melanoma-latest-gwas all 800 Fracture of lower limb Injuries & Poisonings Both 1.01 0.983 1.03 0.568 7230 72297 FALSE 0.245651664288981 0.00707 0.0124 -0.0257 0.0352 0.465 0.975 0.91 1.04 0.031 0.0348 0.372 1.03 0.964 1.1 0.00373 0.0351 0.915 1 0.937 1.08 ukb-melanoma-latest-gwas all 800.1 Fracture of neck of femur Injuries & Poisonings Both 1.01 0.962 1.06 0.68 1813 18130 FALSE 0.167491087293764 0.0102 0.0247 0.00507 0.0701 0.942 1.01 0.876 1.15 -0.000291 0.0702 0.997 1 0.871 1.15 0.0469 0.0699 0.502 1.05 0.914 1.2 ukb-melanoma-latest-gwas all 800.2 Fracture of unspecified part of femur Injuries & Poisonings Both 0.885 0.755 1.04 0.127 170 1700 FALSE 0.896196279044043 -0.123 0.0803 -0.422 0.225 0.0604 0.656 0.417 1.02 -0.286 0.216 0.185 0.751 0.488 1.15 -0.305 0.221 0.169 0.737 0.474 1.14 ukb-melanoma-latest-gwas all 800.3 Fracture of tibia and fibula Injuries & Poisonings Both 1.01 0.966 1.06 0.676 2156 21560 FALSE 0.170053304058364 0.00948 0.0227 0.0594 0.0639 0.352 1.06 0.936 1.2 0.0377 0.0644 0.558 1.04 0.915 1.18 0.0235 0.0648 0.717 1.02 0.902 1.16 ukb-melanoma-latest-gwas all 800.4 Fracture of patella Injuries & Poisonings Both 0.992 0.921 1.07 0.832 766 7660 FALSE 0.0798766737092761 -0.00804 0.038 -0.0821 0.108 0.446 0.921 0.745 1.14 0.0189 0.106 0.858 1.02 0.828 1.25 -0.0517 0.108 0.631 0.95 0.769 1.17 ukb-melanoma-latest-gwas all 801 Fracture of ankle and foot Injuries & Poisonings Both 1.04 0.994 1.08 0.0891 2333 23325 FALSE 1.05012229596313 0.0371 0.0218 -0.0021 0.0621 0.973 0.998 0.884 1.13 0.0338 0.0616 0.583 1.03 0.917 1.17 0.0407 0.0618 0.51 1.04 0.923 1.18 ukb-melanoma-latest-gwas all 801.1 Fracture of foot Injuries & Poisonings Both 1.05 1 1.11 0.0318 1838 18375 TRUE 1.49757288001557 0.0528 0.0246 0.0134 0.0702 0.849 1.01 0.883 1.16 0.0643 0.0696 0.355 1.07 0.93 1.22 0.0647 0.0698 0.354 1.07 0.93 1.22 ukb-melanoma-latest-gwas all 802 Fracture of pelvis Injuries & Poisonings Both 1.02 0.94 1.1 0.703 722 7220 FALSE 0.153044674980176 0.015 0.0392 0.137 0.111 0.22 1.15 0.921 1.43 0.0579 0.114 0.611 1.06 0.847 1.33 0.154 0.112 0.168 1.17 0.937 1.45 ukb-melanoma-latest-gwas all 803 Fracture of upper limb Injuries & Poisonings Both 1.01 0.99 1.04 0.291 8480 84788 FALSE 0.536107011014093 0.0121 0.0114 -0.0151 0.0324 0.64 0.985 0.924 1.05 -0.0121 0.0324 0.708 0.988 0.927 1.05 0.0357 0.0322 0.268 1.04 0.973 1.1 ukb-melanoma-latest-gwas all 803.1 Fracture of humerus Injuries & Poisonings Both 0.984 0.936 1.04 0.541 1685 16840 FALSE 0.266802734893431 -0.0157 0.0256 -0.127 0.0718 0.076 0.88 0.765 1.01 -0.137 0.0719 0.0571 0.872 0.757 1 -0.0631 0.0712 0.375 0.939 0.816 1.08 ukb-melanoma-latest-gwas all 803.2 Fracture of radius and ulna Injuries & Poisonings Both 1.02 0.989 1.05 0.238 5214 52138 FALSE 0.623423042943488 0.0172 0.0146 -0.00718 0.0414 0.862 0.993 0.915 1.08 0.00635 0.0414 0.878 1.01 0.928 1.09 0.0511 0.0412 0.215 1.05 0.971 1.14 ukb-melanoma-latest-gwas all 803.3 Fracture of clavicle or scapula Injuries & Poisonings Both 1.03 0.976 1.09 0.284 1518 15180 FALSE 0.546681659952962 0.0289 0.027 0.0495 0.0773 0.522 1.05 0.903 1.22 0.0773 0.077 0.316 1.08 0.929 1.26 0.105 0.0768 0.17 1.11 0.956 1.29 ukb-melanoma-latest-gwas all 804 Fracture of hand or wrist Injuries & Poisonings Both 0.986 0.952 1.02 0.439 3349 33490 FALSE 0.357535479757879 -0.0141 0.0182 -0.0662 0.0508 0.193 0.936 0.847 1.03 -0.0937 0.0512 0.067 0.911 0.824 1.01 -0.0572 0.051 0.262 0.944 0.855 1.04 ukb-melanoma-latest-gwas all 805 Fracture of vertebral column without mention of spinal cord injury Injuries & Poisonings Both 1.04 0.984 1.1 0.16 1359 13590 FALSE 0.795880017344075 0.0401 0.0285 0.0633 0.0809 0.434 1.07 0.909 1.25 0.0221 0.0816 0.787 1.02 0.871 1.2 0.0792 0.0809 0.328 1.08 0.924 1.27 ukb-melanoma-latest-gwas all 807 Fracture of ribs Injuries & Poisonings Both 0.977 0.908 1.05 0.544 778 7780 FALSE 0.26440110030182 -0.0229 0.0377 -0.0419 0.107 0.695 0.959 0.777 1.18 0.0924 0.104 0.375 1.1 0.894 1.35 -0.0619 0.108 0.568 0.94 0.759 1.16 ukb-melanoma-latest-gwas all 809 Fracture of unspecified bones Injuries & Poisonings Both 1.02 0.962 1.08 0.536 1306 13060 FALSE 0.27083521030723 0.0181 0.0292 0.0169 0.0826 0.838 1.02 0.865 1.2 0.0388 0.0822 0.637 1.04 0.885 1.22 0.0311 0.083 0.708 1.03 0.877 1.21 ukb-melanoma-latest-gwas all 817 Concussion Injuries & Poisonings Both 1.13 0.987 1.29 0.0774 245 2450 FALSE 1.11125903931711 0.119 0.0675 0.295 0.209 0.158 1.34 0.89 2.04 0.603 0.199 0.00242 1.83 1.24 2.73 0.47 0.204 0.0215 1.6 1.07 2.41 ukb-melanoma-latest-gwas all 818 Intracranial hemorrhage (injury) Injuries & Poisonings Both 0.993 0.907 1.09 0.876 526 5260 FALSE 0.0574958938319193 -0.00713 0.0458 0.0859 0.128 0.504 1.09 0.847 1.4 0.0343 0.13 0.792 1.03 0.801 1.34 0.0397 0.131 0.763 1.04 0.803 1.35 ukb-melanoma-latest-gwas all 819 Skull and face fracture and other intercranial injury Injuries & Poisonings Both 1.01 0.973 1.05 0.573 2967 29665 FALSE 0.24184537803261 0.0109 0.0194 -0.0151 0.055 0.784 0.985 0.884 1.1 0.0191 0.0547 0.726 1.02 0.916 1.13 0.0554 0.0548 0.311 1.06 0.949 1.18 ukb-melanoma-latest-gwas all 823 Torus fracture Injuries & Poisonings Both 1.01 0.961 1.06 0.674 1676 16752 FALSE 0.17134010346468 0.0108 0.0257 0.0339 0.0726 0.641 1.03 0.897 1.19 0.0135 0.0731 0.853 1.01 0.878 1.17 0.0355 0.073 0.626 1.04 0.898 1.2 ukb-melanoma-latest-gwas all 830 Dislocation Injuries & Poisonings Both 1.04 0.997 1.09 0.0673 2092 20914 FALSE 1.17198493577602 0.0422 0.0231 0.0186 0.0661 0.779 1.02 0.895 1.16 0.0411 0.0659 0.533 1.04 0.916 1.19 0.145 0.0648 0.0255 1.16 1.02 1.31 ukb-melanoma-latest-gwas all 835 Internal derangement of knee Injuries & Poisonings Both 1.01 0.994 1.03 0.217 15259 152537 FALSE 0.66354026615147 0.0105 0.00853 0.0271 0.0242 0.263 1.03 0.98 1.08 0.0372 0.0242 0.124 1.04 0.99 1.09 0.0432 0.0243 0.0749 1.04 0.996 1.09 ukb-melanoma-latest-gwas all 836 Traumatic arthropathy Injuries & Poisonings Both 1.08 0.987 1.18 0.0944 527 5270 FALSE 1.02502800570193 0.0766 0.0458 0.173 0.133 0.193 1.19 0.916 1.55 0.163 0.134 0.224 1.18 0.905 1.53 0.281 0.13 0.031 1.32 1.03 1.71 ukb-melanoma-latest-gwas all 840 Sprains and strains Injuries & Poisonings Both 1.06 0.966 1.16 0.215 496 4960 FALSE 0.667561540084395 0.0585 0.0473 -0.0335 0.136 0.805 0.967 0.74 1.26 0.0265 0.134 0.844 1.03 0.788 1.34 0.156 0.132 0.235 1.17 0.903 1.52 ukb-melanoma-latest-gwas all 850 Hemorrhage or hematoma complicating a procedure Injuries & Poisonings Both 1.03 0.999 1.06 0.0579 5327 53270 FALSE 1.23732143627256 0.0274 0.0144 0.0521 0.0411 0.204 1.05 0.972 1.14 0.0451 0.0412 0.274 1.05 0.965 1.13 0.0807 0.041 0.049 1.08 1 1.17 ukb-melanoma-latest-gwas all 851 Complications of transplants and reattached limbs Injuries & Poisonings Both 1.21 1.03 1.43 0.0217 159 1590 TRUE 1.66354026615147 0.191 0.083 0.541 0.263 0.0395 1.72 1.03 2.93 0.509 0.262 0.052 1.66 0.996 2.83 0.721 0.255 0.00465 2.06 1.25 3.46 ukb-melanoma-latest-gwas all 853 Complication of colostomy or enterostomy Injuries & Poisonings Both 0.998 0.91 1.09 0.971 503 5030 FALSE 0.0127807700919951 -0.00169 0.0469 -0.0788 0.134 0.556 0.924 0.71 1.2 0.000108 0.132 0.999 1 0.771 1.3 0.0221 0.131 0.867 1.02 0.789 1.32 ukb-melanoma-latest-gwas all 854 Complications of cardiac/vascular device, implant, and graft Injuries & Poisonings Both 0.989 0.943 1.04 0.668 1830 18300 FALSE 0.175223537524454 -0.0106 0.0246 0.00068 0.0691 0.992 1 0.874 1.15 -0.0236 0.0694 0.734 0.977 0.852 1.12 -0.0226 0.0696 0.745 0.978 0.853 1.12 ukb-melanoma-latest-gwas all 857 Mechanical complication of unspecified genitourinary device, implant, and graft Injuries & Poisonings Both 1.02 0.964 1.08 0.456 1246 12460 FALSE 0.341035157335565 0.0222 0.0298 0.0149 0.0845 0.86 1.02 0.86 1.2 0.00254 0.0847 0.976 1 0.849 1.18 0.056 0.0841 0.506 1.06 0.897 1.25 ukb-melanoma-latest-gwas all 858 Complication of internal orthopedic device Injuries & Poisonings Both 0.977 0.941 1.01 0.204 3163 31630 FALSE 0.690369832574101 -0.0238 0.0187 0.00138 0.0519 0.979 1 0.904 1.11 -0.13 0.0536 0.0153 0.878 0.79 0.975 -0.018 0.0524 0.731 0.982 0.886 1.09 ukb-melanoma-latest-gwas all 859 Complication due to other implant and internal device Injuries & Poisonings Both 1 0.969 1.04 0.82 3268 32680 FALSE 0.0861861476162833 0.0042 0.0184 -0.0338 0.0525 0.52 0.967 0.872 1.07 0.0333 0.0518 0.52 1.03 0.934 1.14 0.0291 0.052 0.576 1.03 0.93 1.14 ukb-melanoma-latest-gwas all 860 Bone marrow or stem cell transplant Neoplasms Both 0.838 0.663 1.06 0.133 80 800 FALSE 0.876148359032914 -0.177 0.117 -0.519 0.309 0.0936 0.595 0.317 1.09 -0.483 0.308 0.116 0.617 0.33 1.13 -0.754 0.33 0.0223 0.47 0.238 0.893 ukb-melanoma-latest-gwas all 870 Open wounds of head; neck; and trunk Injuries & Poisonings Both 0.988 0.955 1.02 0.472 3836 38342 FALSE 0.326058001365912 -0.0122 0.017 -0.0737 0.0482 0.126 0.929 0.845 1.02 -0.0261 0.0478 0.585 0.974 0.887 1.07 3.92e-05 0.0478 0.999 1 0.911 1.1 ukb-melanoma-latest-gwas all 870.1 Open wound or laceration of eye or eyelid Injuries & Poisonings Both 1 0.884 1.14 0.978 270 2700 FALSE 0.00966114521239857 0.00176 0.0637 0.102 0.179 0.57 1.11 0.778 1.58 -0.00981 0.184 0.958 0.99 0.688 1.43 0.0796 0.18 0.658 1.08 0.76 1.55 ukb-melanoma-latest-gwas all 870.2 Open wound of ear Injuries & Poisonings Both 1.04 0.897 1.21 0.601 195 1950 FALSE 0.22112552799726 0.0392 0.075 -0.327 0.219 0.135 0.721 0.465 1.11 -0.0896 0.208 0.666 0.914 0.605 1.38 0.0369 0.202 0.855 1.04 0.696 1.55 ukb-melanoma-latest-gwas all 870.3 Other open wound of head and face Injuries & Poisonings Both 0.978 0.942 1.02 0.262 2915 29141 FALSE 0.581698708680255 -0.0219 0.0195 -0.0874 0.0553 0.114 0.916 0.822 1.02 -0.0178 0.0546 0.744 0.982 0.883 1.09 -0.0142 0.0549 0.796 0.986 0.885 1.1 ukb-melanoma-latest-gwas all 870.4 Open wound of nose and sinus Injuries & Poisonings Both 1.05 0.915 1.21 0.478 220 2200 FALSE 0.320572103387881 0.0501 0.0707 0.198 0.201 0.324 1.22 0.821 1.82 0.0961 0.207 0.642 1.1 0.731 1.66 0.213 0.201 0.29 1.24 0.833 1.85 ukb-melanoma-latest-gwas all 870.6 Open wound of neck Injuries & Poisonings Both 0.899 0.8 1.01 0.0711 313 3130 FALSE 1.14813039927023 -0.107 0.0591 -0.0231 0.159 0.885 0.977 0.714 1.34 -0.0844 0.162 0.603 0.919 0.667 1.27 -0.327 0.174 0.06 0.721 0.51 1.01 ukb-melanoma-latest-gwas all 871 Open wounds of extremities Injuries & Poisonings Both 0.972 0.942 1 0.0789 4216 42160 FALSE 1.10292299679058 -0.0285 0.0162 -0.0397 0.0452 0.38 0.961 0.88 1.05 -0.0553 0.0454 0.223 0.946 0.866 1.03 -0.0925 0.046 0.0442 0.912 0.833 0.998 ukb-melanoma-latest-gwas all 871.1 Open wound of hand except finger(s) Injuries & Poisonings Both 1.16 0.875 1.55 0.288 53 530 FALSE 0.540607512240769 0.152 0.143 0.495 0.419 0.238 1.64 0.713 3.96 0.307 0.43 0.475 1.36 0.57 3.35 0.538 0.415 0.195 1.71 0.756 4.1 ukb-melanoma-latest-gwas all 871.2 Open wound of finger(s) Injuries & Poisonings Both 1 0.809 1.25 0.973 91 910 FALSE 0.0118871597316481 0.00374 0.109 -0.144 0.305 0.638 0.866 0.469 1.59 -0.0562 0.3 0.851 0.945 0.518 1.72 -0.0883 0.303 0.771 0.915 0.498 1.68 ukb-melanoma-latest-gwas all 871.3 Open wound of foot except toe(s) alone Injuries & Poisonings Both 0.901 0.772 1.05 0.183 179 1790 FALSE 0.73754891026957 -0.104 0.0783 0.145 0.208 0.484 1.16 0.768 1.75 -0.0698 0.217 0.748 0.933 0.606 1.43 -0.331 0.233 0.156 0.718 0.45 1.14 ukb-melanoma-latest-gwas all 872 Traumatic amputation Injuries & Poisonings Both 0.978 0.889 1.07 0.639 476 4760 FALSE 0.1944991418416 -0.0226 0.0482 0.0443 0.135 0.743 1.05 0.801 1.36 -0.0137 0.137 0.921 0.986 0.752 1.29 0.0572 0.136 0.675 1.06 0.81 1.39 ukb-melanoma-latest-gwas all 873 Broken tooth Injuries & Poisonings Both 0.976 0.852 1.12 0.72 229 2290 FALSE 0.142667503568732 -0.0247 0.0689 -0.256 0.196 0.191 0.774 0.524 1.14 -0.116 0.189 0.539 0.891 0.613 1.29 -0.13 0.19 0.496 0.878 0.602 1.28 ukb-melanoma-latest-gwas all 874 Complication of amputation stump Injuries & Poisonings Both 1.07 0.914 1.25 0.402 172 1720 FALSE 0.39577394691553 0.067 0.0799 0.054 0.232 0.816 1.06 0.667 1.67 0.142 0.229 0.535 1.15 0.733 1.82 0.223 0.225 0.321 1.25 0.802 1.96 ukb-melanoma-latest-gwas all 905 Late effects of musculoskeletal and connective tissue injuries Injuries & Poisonings Both 0.935 0.794 1.1 0.422 158 1580 FALSE 0.374687549038326 -0.0668 0.0832 0.166 0.226 0.464 1.18 0.755 1.85 0.00127 0.233 0.996 1 0.63 1.59 -0.171 0.243 0.482 0.843 0.518 1.36 ukb-melanoma-latest-gwas all 907 Injuries to the nervous system Injuries & Poisonings Both 0.989 0.935 1.05 0.714 1315 13150 FALSE 0.146301788223826 -0.0106 0.029 0.0496 0.0816 0.543 1.05 0.895 1.23 0.0388 0.082 0.636 1.04 0.885 1.22 -0.000149 0.083 0.999 1 0.849 1.18 ukb-melanoma-latest-gwas all 915 Superficial injury without mention of infection Injuries & Poisonings Both 1.02 0.989 1.05 0.211 4278 42778 FALSE 0.675717544702307 0.0201 0.0161 0.0107 0.046 0.816 1.01 0.924 1.11 0.039 0.0457 0.394 1.04 0.951 1.14 0.0836 0.0456 0.0665 1.09 0.994 1.19 ukb-melanoma-latest-gwas all 916 Contusion Injuries & Poisonings Both 0.954 0.904 1.01 0.0826 1484 14840 FALSE 1.08301995267962 -0.0474 0.0273 0.0175 0.0757 0.818 1.02 0.877 1.18 -0.0572 0.0772 0.459 0.944 0.812 1.1 -0.0784 0.0777 0.313 0.925 0.794 1.08 ukb-melanoma-latest-gwas all 930 Allergic reaction to food Injuries & Poisonings Both 0.999 0.858 1.17 0.992 183 1830 FALSE 0.00348832784582135 -0.000811 0.0775 -0.0623 0.221 0.778 0.94 0.605 1.46 0.0364 0.217 0.867 1.04 0.675 1.59 0.0153 0.217 0.944 1.02 0.66 1.56 ukb-melanoma-latest-gwas all 938 Dermatitis due to solar radiation Injuries & Poisonings Both 1.25 1.13 1.39 2.95e-05 390 3900 TRUE 4.53017798402184 0.224 0.0536 0.196 0.166 0.24 1.22 0.877 1.69 0.34 0.162 0.0352 1.41 1.02 1.94 0.662 0.153 1.58e-05 1.94 1.44 2.63 ukb-melanoma-latest-gwas all 938.2 Chronic dermatitis due to solar radiation Injuries & Poisonings Both 1.27 1.12 1.45 0.000256 253 2530 TRUE 3.59176003468815 0.242 0.0663 0.261 0.208 0.208 1.3 0.863 1.97 0.428 0.201 0.0336 1.53 1.03 2.3 0.717 0.193 0.000201 2.05 1.41 3.02 ukb-melanoma-latest-gwas all 939 Atopic/contact dermatitis due to other or unspecified Dermatologic Both 1.02 0.978 1.07 0.332 2105 21050 FALSE 0.478861916295964 0.0223 0.023 0.0319 0.0654 0.625 1.03 0.908 1.17 0.0473 0.0653 0.469 1.05 0.922 1.19 0.0809 0.065 0.214 1.08 0.954 1.23 ukb-melanoma-latest-gwas all 941 Adverse reaction to serum or vaccine Injuries & Poisonings Both 0.902 0.787 1.03 0.139 225 2250 FALSE 0.856985199745905 -0.103 0.0695 -0.0185 0.186 0.921 0.982 0.68 1.42 -0.143 0.193 0.459 0.867 0.591 1.27 -0.369 0.204 0.0705 0.692 0.46 1.03 ukb-melanoma-latest-gwas all 942 Infusion and transfusion reaction Injuries & Poisonings Both 0.889 0.726 1.09 0.25 104 1040 FALSE 0.602059991327962 -0.117 0.102 -0.055 0.275 0.842 0.946 0.546 1.64 -0.0906 0.277 0.744 0.913 0.524 1.59 -0.254 0.293 0.386 0.776 0.43 1.39 ukb-melanoma-latest-gwas all 946 Anaphylactic shock NOS Injuries & Poisonings Both 1.05 0.959 1.14 0.298 551 5510 FALSE 0.525783735923745 0.0466 0.0448 0.132 0.127 0.299 1.14 0.889 1.47 0.0186 0.131 0.887 1.02 0.788 1.32 0.152 0.127 0.232 1.16 0.907 1.5 ukb-melanoma-latest-gwas all 947 Urticaria Injuries & Poisonings Both 1.07 0.966 1.2 0.186 373 3730 FALSE 0.730487055782084 0.0719 0.0543 0.206 0.16 0.198 1.23 0.897 1.69 0.266 0.158 0.0929 1.3 0.956 1.79 0.28 0.158 0.0765 1.32 0.97 1.81 ukb-melanoma-latest-gwas all 949 Allergies, other Injuries & Poisonings Both 1.1 0.991 1.22 0.0716 399 3990 FALSE 1.14508697769214 0.095 0.0527 -0.00993 0.157 0.95 0.99 0.726 1.35 0.319 0.148 0.0306 1.38 1.03 1.84 0.182 0.151 0.23 1.2 0.891 1.62 ukb-melanoma-latest-gwas all 952 Spinal cord injury without evidence of spinal bone injury Injuries & Poisonings Both 1.1 0.99 1.21 0.0759 423 4230 FALSE 1.11975822410452 0.0912 0.0514 0.0272 0.145 0.851 1.03 0.773 1.37 -0.0273 0.147 0.853 0.973 0.728 1.3 0.114 0.143 0.427 1.12 0.846 1.49 ukb-melanoma-latest-gwas all 957 Injury to other and unspecified nerves Injuries & Poisonings Both 1.02 0.9 1.16 0.75 270 2700 FALSE 0.1249387366083 0.0203 0.0638 0.0687 0.181 0.704 1.07 0.75 1.53 0.0149 0.183 0.935 1.02 0.707 1.46 0.109 0.18 0.545 1.12 0.782 1.59 ukb-melanoma-latest-gwas all 958 Certain early complications of trauma or procedure Injuries & Poisonings Both 0.967 0.882 1.06 0.473 497 4970 FALSE 0.325138859262188 -0.0337 0.047 0.128 0.129 0.322 1.14 0.882 1.46 -0.0348 0.133 0.794 0.966 0.743 1.25 -0.132 0.137 0.335 0.877 0.669 1.15 ukb-melanoma-latest-gwas all 958.1 Postoperative shock Injuries & Poisonings Both 0.97 0.736 1.28 0.824 56 560 FALSE 0.0840727883028842 -0.0305 0.137 0.464 0.375 0.216 1.59 0.761 3.44 0.104 0.399 0.794 1.11 0.495 2.51 0.161 0.416 0.699 1.17 0.505 2.76 ukb-melanoma-latest-gwas all 958.2 Traumatic and surgical subcutaneous emphysema Injuries & Poisonings Both 0.882 0.695 1.12 0.297 74 740 FALSE 0.527243550682788 -0.125 0.12 0.494 0.326 0.13 1.64 0.865 3.19 0.129 0.343 0.708 1.14 0.573 2.28 -0.264 0.375 0.482 0.768 0.356 1.63 ukb-melanoma-latest-gwas all 960 Poisoning by antibiotics Injuries & Poisonings Both 1 0.99 1.02 0.539 18183 181830 FALSE 0.268411234813261 0.0048 0.00781 0.0516 0.0221 0.0194 1.05 1.01 1.1 0.0439 0.0221 0.0472 1.04 1 1.09 0.0205 0.0223 0.357 1.02 0.977 1.07 ukb-melanoma-latest-gwas all 960.2 Allergy/adverse effect of penicillin Injuries & Poisonings Both 1 0.984 1.02 0.937 15871 158710 FALSE 0.0282604091122217 0.00066 0.00836 0.0448 0.0235 0.0571 1.05 0.999 1.1 0.0266 0.0237 0.261 1.03 0.98 1.08 0.00464 0.0239 0.846 1 0.959 1.05 ukb-melanoma-latest-gwas all 961 Poisoning by other anti-infectives Injuries & Poisonings Both 0.963 0.871 1.06 0.461 420 4200 FALSE 0.336299074610352 -0.0377 0.0512 -0.00231 0.143 0.987 0.998 0.753 1.32 -0.0523 0.145 0.718 0.949 0.713 1.26 -0.0248 0.145 0.864 0.976 0.734 1.3 ukb-melanoma-latest-gwas all 962 Poisoning by hormones and synthetic substitutes Injuries & Poisonings Both 1.06 0.956 1.18 0.26 382 3820 FALSE 0.585026652029182 0.0604 0.0536 -0.105 0.156 0.5 0.9 0.662 1.22 0.0675 0.15 0.653 1.07 0.796 1.44 0.0972 0.149 0.514 1.1 0.822 1.48 ukb-melanoma-latest-gwas all 962.3 Hormones and synthetic substitutes causing adverse effects in therapeutic use Injuries & Poisonings Both 1.06 0.955 1.19 0.259 364 3640 FALSE 0.586700235918748 0.0621 0.055 -0.123 0.16 0.443 0.885 0.645 1.21 0.0801 0.153 0.602 1.08 0.801 1.47 0.0818 0.153 0.593 1.09 0.803 1.47 ukb-melanoma-latest-gwas all 963 Poisoning by primarily systemic agents Injuries & Poisonings Both 0.953 0.831 1.09 0.487 226 2260 FALSE 0.312471038785366 -0.0483 0.0695 0.0438 0.194 0.821 1.04 0.712 1.53 0.156 0.19 0.411 1.17 0.804 1.71 -0.197 0.206 0.34 0.821 0.544 1.23 ukb-melanoma-latest-gwas all 964 Poisoning by agents primarily affecting blood constituents Injuries & Poisonings Both 1.01 0.892 1.14 0.902 288 2880 FALSE 0.0447934624580583 0.00757 0.0617 -0.127 0.176 0.47 0.88 0.62 1.25 0.109 0.167 0.514 1.12 0.802 1.55 -0.138 0.177 0.436 0.871 0.614 1.23 ukb-melanoma-latest-gwas all 964.1 Anticoagulants causing adverse effects Injuries & Poisonings Both 1.04 0.92 1.18 0.526 278 2780 FALSE 0.279014255846261 0.0398 0.0626 -0.13 0.182 0.476 0.878 0.612 1.26 0.149 0.172 0.387 1.16 0.828 1.63 -0.0477 0.178 0.789 0.953 0.67 1.36 ukb-melanoma-latest-gwas all 965 Poisoning by analgesics, antipyretics, and antirheumatics Injuries & Poisonings Both 0.987 0.961 1.01 0.331 6135 61345 FALSE 0.480172006224281 -0.0131 0.0135 0.0472 0.0377 0.21 1.05 0.974 1.13 0.00887 0.038 0.816 1.01 0.936 1.09 -0.0232 0.0385 0.546 0.977 0.906 1.05 ukb-melanoma-latest-gwas all 965.1 Opiates and related narcotics causing adverse effects in therapeutic use Injuries & Poisonings Both 1.06 0.954 1.18 0.279 392 3920 FALSE 0.554395796726402 0.0574 0.053 0.266 0.156 0.0874 1.31 0.961 1.78 0.36 0.154 0.0192 1.43 1.06 1.94 0.258 0.159 0.104 1.29 0.948 1.77 ukb-melanoma-latest-gwas all 965.2 Antirheumatics causing adverse effects in therapeutic use Injuries & Poisonings Both 1.01 0.922 1.11 0.783 477 4765 FALSE 0.106238237942057 0.0133 0.0482 -0.000355 0.135 0.998 1 0.766 1.3 -0.0983 0.138 0.477 0.906 0.69 1.19 0.0226 0.134 0.866 1.02 0.786 1.33 ukb-melanoma-latest-gwas all 965.3 Salicylates causing adverse effects in therapeutic use Injuries & Poisonings Both 1.01 0.911 1.12 0.85 403 4025 FALSE 0.0705810742857073 0.00991 0.0524 0.172 0.146 0.238 1.19 0.892 1.59 0.0794 0.149 0.595 1.08 0.807 1.45 -0.0109 0.153 0.943 0.989 0.732 1.34 ukb-melanoma-latest-gwas all 966 Poisoning by anticonvulsants and anti-Parkinsonism drugs Injuries & Poisonings Both 0.948 0.865 1.04 0.249 513 5130 FALSE 0.603800652904264 -0.0535 0.0464 -0.177 0.131 0.177 0.838 0.646 1.08 -0.00964 0.126 0.939 0.99 0.772 1.27 -0.153 0.131 0.244 0.858 0.662 1.11 ukb-melanoma-latest-gwas all 967 Adverse effects of sedatives or other central nervous system depressants and anesthetics Injuries & Poisonings Both 1 0.92 1.09 0.969 590 5900 FALSE 0.0136762229492347 0.00166 0.0433 0.0962 0.122 0.431 1.1 0.866 1.4 0.099 0.122 0.418 1.1 0.868 1.4 0.0218 0.125 0.861 1.02 0.8 1.31 ukb-melanoma-latest-gwas all 969 Poisoning by psychotropic agents Injuries & Poisonings Both 0.959 0.915 1 0.0773 1960 19589 FALSE 1.11182050608168 -0.0421 0.0238 -0.0506 0.0667 0.448 0.951 0.834 1.08 -0.0486 0.0669 0.468 0.953 0.835 1.09 -0.0561 0.0671 0.403 0.945 0.829 1.08 ukb-melanoma-latest-gwas all 971 Poisoning by drugs primarily affecting the autonomic nervous system Injuries & Poisonings Both 0.992 0.854 1.15 0.915 192 1920 FALSE 0.0385789059335517 -0.00806 0.0757 -0.271 0.221 0.22 0.763 0.49 1.18 -0.0225 0.21 0.914 0.978 0.645 1.48 0.119 0.205 0.562 1.13 0.752 1.69 ukb-melanoma-latest-gwas all 972 Poisoning by agents primarily affecting the cardiovascular system Injuries & Poisonings Both 0.931 0.823 1.05 0.254 282 2820 FALSE 0.595166283380062 -0.0714 0.0626 0.0226 0.172 0.896 1.02 0.728 1.44 0.068 0.172 0.693 1.07 0.763 1.5 -0.183 0.182 0.317 0.833 0.58 1.19 ukb-melanoma-latest-gwas all 972.6 Antihypertensive agents causing adverse effects Injuries & Poisonings Both 1.01 0.806 1.26 0.95 85 850 FALSE 0.0222763947111523 0.00708 0.112 0.232 0.32 0.469 1.26 0.668 2.41 0.261 0.316 0.41 1.3 0.693 2.47 0.15 0.329 0.65 1.16 0.601 2.26 ukb-melanoma-latest-gwas all 973 Poisoning by agents primarily affecting the gastrointestinal system Injuries & Poisonings Both 1.15 0.943 1.41 0.163 108 1080 FALSE 0.787812395596042 0.141 0.101 0.154 0.3 0.608 1.17 0.641 2.14 0.37 0.288 0.2 1.45 0.82 2.6 0.409 0.291 0.16 1.51 0.849 2.72 ukb-melanoma-latest-gwas all 974 Poisoning by water, mineral, and uric acid metabolism drugs Injuries & Poisonings Both 0.991 0.807 1.22 0.934 102 1020 FALSE 0.0296531237699066 -0.00854 0.103 0.604 0.285 0.0345 1.83 1.05 3.27 -0.174 0.333 0.602 0.841 0.426 1.64 0.287 0.301 0.339 1.33 0.735 2.45 ukb-melanoma-latest-gwas all 975 Poisoning by agents primarily acting on the smooth and skeletal muscles and respiratory system Injuries & Poisonings Both 1.22 0.944 1.58 0.122 64 640 FALSE 0.913640169325252 0.2 0.13 0.835 0.415 0.0443 2.31 1.02 5.62 0.991 0.417 0.0174 2.7 1.2 6.59 0.68 0.428 0.112 1.97 0.847 4.92 ukb-melanoma-latest-gwas all 976 Poisoning by agents primarily affecting skin & mucous membrane, ophthalmological, otorhinolaryngological, & dental drugs Injuries & Poisonings Both 1.02 0.775 1.33 0.903 58 580 FALSE 0.0443122496864942 0.0164 0.136 -0.757 0.416 0.0688 0.469 0.192 1.06 -0.337 0.366 0.357 0.714 0.34 1.47 -0.181 0.349 0.605 0.835 0.413 1.67 ukb-melanoma-latest-gwas all 977 Personal history of allergy to medicinal agents Injuries & Poisonings Both 1.14 0.993 1.3 0.0607 235 2350 FALSE 1.21681130892474 0.128 0.0681 0.112 0.206 0.586 1.12 0.744 1.69 0.418 0.194 0.0311 1.52 1.04 2.24 0.216 0.203 0.287 1.24 0.832 1.86 ukb-melanoma-latest-gwas all 979 Adverse drug events and drug allergies Injuries & Poisonings Both 1.03 0.951 1.11 0.482 699 6983 FALSE 0.31695296176115 0.028 0.0398 0.0432 0.114 0.704 1.04 0.835 1.31 0.188 0.11 0.0893 1.21 0.972 1.5 -0.037 0.116 0.75 0.964 0.767 1.21 ukb-melanoma-latest-gwas all 981 Toxic effect of (non-ethyl) alcohol and petroleum and other solvents Injuries & Poisonings Both 0.985 0.852 1.14 0.839 201 2010 FALSE 0.0762380391712997 -0.015 0.0738 -0.316 0.221 0.152 0.729 0.468 1.12 0.0263 0.202 0.897 1.03 0.688 1.53 0.0674 0.201 0.737 1.07 0.719 1.59 ukb-melanoma-latest-gwas all 986 Toxic effect of carbon monoxide Injuries & Poisonings Both 1 0.787 1.27 0.986 73 730 FALSE 0.00612308505878879 0.00212 0.121 0.119 0.347 0.731 1.13 0.561 2.27 0.1 0.34 0.768 1.11 0.559 2.2 0.195 0.345 0.572 1.22 0.61 2.45 ukb-melanoma-latest-gwas all 987 Toxic effect of other gases, fumes, or vapors Injuries & Poisonings Both 1.06 0.87 1.3 0.534 106 1060 FALSE 0.272458742971444 0.0629 0.101 0.111 0.283 0.696 1.12 0.636 1.97 -0.27 0.308 0.381 0.763 0.408 1.41 0.304 0.278 0.274 1.35 0.783 2.37 ukb-melanoma-latest-gwas all 988 Toxic effect of noxious substances eaten as food Injuries & Poisonings Both 0.885 0.731 1.07 0.21 113 1130 FALSE 0.677780705266081 -0.122 0.0972 -0.408 0.278 0.142 0.665 0.379 1.15 -0.295 0.271 0.277 0.745 0.431 1.27 -0.177 0.263 0.501 0.838 0.496 1.41 ukb-melanoma-latest-gwas all 989 Toxic effect of other substances, chiefly nonmedicinal as to source Injuries & Poisonings Both 1.02 0.82 1.27 0.86 89 890 FALSE 0.0655015487564323 0.0195 0.11 0.312 0.3 0.299 1.37 0.756 2.51 0.15 0.31 0.628 1.16 0.625 2.18 -0.111 0.329 0.737 0.895 0.459 1.73 ukb-melanoma-latest-gwas all 990 Effects radiation NOS Injuries & Poisonings Both 1.01 0.971 1.05 0.697 3122 31220 FALSE 0.156767221901991 0.00733 0.0188 0.0643 0.0529 0.225 1.07 0.961 1.18 -0.0147 0.0539 0.785 0.985 0.886 1.1 0.0401 0.0533 0.452 1.04 0.938 1.16 ukb-melanoma-latest-gwas all 994 Sepsis and SIRS Injuries & Poisonings Both 1 0.964 1.04 0.983 3036 30360 FALSE 0.00744648216786438 0.000406 0.0191 -0.000179 0.0539 0.997 1 0.899 1.11 0.0243 0.0537 0.651 1.02 0.922 1.14 -0.0223 0.0545 0.683 0.978 0.879 1.09 ukb-melanoma-latest-gwas all 994.2 Sepsis Injuries & Poisonings Both 1 0.964 1.04 0.983 3036 30360 FALSE 0.00744648216786438 0.000406 0.0191 -0.000179 0.0539 0.997 1 0.899 1.11 0.0243 0.0537 0.651 1.02 0.922 1.14 -0.0223 0.0545 0.683 0.978 0.879 1.09 ukb-melanoma-latest-gwas all 1000 Burns Injuries & Poisonings Both 1.04 0.951 1.13 0.415 582 5813 FALSE 0.381951903287907 0.0356 0.0438 0.203 0.126 0.108 1.22 0.956 1.57 0.233 0.126 0.0648 1.26 0.986 1.62 0.214 0.128 0.0937 1.24 0.964 1.59 ukb-melanoma-latest-gwas all 1001 Foreign body injury Injuries & Poisonings Both 1.01 0.956 1.08 0.642 1231 12305 FALSE 0.192464971931147 0.0139 0.03 0.0413 0.0854 0.629 1.04 0.881 1.23 0.173 0.0831 0.0374 1.19 1.01 1.4 -0.0725 0.0878 0.409 0.93 0.783 1.11 ukb-melanoma-latest-gwas all 1002 Symptoms concerning nutrition, metabolism, and development Injuries & Poisonings Both 1 0.974 1.03 0.939 5493 54927 FALSE 0.0273344077338891 0.00109 0.0142 0.015 0.0399 0.707 1.02 0.939 1.1 -0.0014 0.0401 0.972 0.999 0.923 1.08 -0.0294 0.0404 0.467 0.971 0.897 1.05 ukb-melanoma-latest-gwas all 1004 Other signs and symptoms involving emotional state Injuries & Poisonings Both 1.02 0.906 1.15 0.74 301 3010 FALSE 0.130768280269024 0.0201 0.0605 0.0461 0.172 0.788 1.05 0.746 1.47 0.101 0.169 0.55 1.11 0.793 1.55 -0.0121 0.174 0.944 0.988 0.7 1.39 ukb-melanoma-latest-gwas all 1005 Other symptoms Injuries & Poisonings Both 1.03 0.974 1.09 0.319 1449 14484 FALSE 0.496209316942819 0.0275 0.0277 -0.0527 0.0793 0.506 0.949 0.812 1.11 0.0477 0.0775 0.539 1.05 0.901 1.22 0.04 0.0779 0.607 1.04 0.893 1.21 ukb-melanoma-latest-gwas all 1006 Crushing injury Injuries & Poisonings Both 0.821 0.722 0.934 0.00262 258 2580 TRUE 2.58169870868025 -0.197 0.0654 -0.0388 0.17 0.819 0.962 0.688 1.34 -0.391 0.186 0.0355 0.677 0.467 0.973 -0.432 0.189 0.0223 0.649 0.445 0.939 ukb-melanoma-latest-gwas all 1007 Injury to blood vessels Injuries & Poisonings Both 0.869 0.765 0.988 0.0309 256 2560 TRUE 1.51004152057517 -0.14 0.0649 -0.167 0.174 0.337 0.847 0.6 1.19 -0.36 0.182 0.0477 0.698 0.486 0.996 -0.416 0.185 0.0248 0.66 0.456 0.948 ukb-melanoma-latest-gwas all 1008 Crushing or internal injury to organs Injuries & Poisonings Both 0.975 0.914 1.04 0.439 1014 10140 FALSE 0.357535479757879 -0.0256 0.033 -0.0925 0.0933 0.321 0.912 0.759 1.09 0.00326 0.0918 0.972 1 0.838 1.2 -0.0811 0.0936 0.386 0.922 0.767 1.11 ukb-melanoma-latest-gwas all 1009 Injury, NOS Injuries & Poisonings Both 0.997 0.975 1.02 0.769 8505 85048 FALSE 0.114073660198569 -0.00335 0.0114 0.00456 0.0322 0.888 1 0.943 1.07 0.00977 0.0322 0.762 1.01 0.948 1.08 0.00186 0.0325 0.954 1 0.94 1.07 ukb-melanoma-latest-gwas all 1010 Other tests Injuries & Poisonings Both 1.02 0.99 1.04 0.208 5979 59790 FALSE 0.681936665037238 0.0171 0.0136 0.0281 0.0387 0.468 1.03 0.953 1.11 0.0289 0.0388 0.456 1.03 0.954 1.11 0.0686 0.0385 0.0751 1.07 0.993 1.16 ukb-melanoma-latest-gwas all 1011 Complications of surgical and medical procedures Injuries & Poisonings Both 0.991 0.97 1.01 0.414 9182 91820 FALSE 0.382999658879101 -0.00897 0.011 0.0195 0.0308 0.526 1.02 0.96 1.08 -0.0496 0.0314 0.114 0.952 0.895 1.01 0.0198 0.031 0.522 1.02 0.96 1.08 ukb-melanoma-latest-gwas all 1012 Late effect Injuries & Poisonings Both 1.03 0.838 1.26 0.808 106 1060 FALSE 0.0925886392254138 0.0249 0.102 0.236 0.305 0.44 1.27 0.691 2.35 0.584 0.288 0.0424 1.79 1.02 3.23 0.131 0.318 0.681 1.14 0.602 2.17 ukb-melanoma-latest-gwas all 1013 Asphyxia and hypoxemia Injuries & Poisonings Both 1.08 0.963 1.22 0.184 317 3170 FALSE 0.735182176990464 0.0784 0.0591 -0.122 0.175 0.485 0.885 0.626 1.25 0.0563 0.169 0.739 1.06 0.758 1.48 0.273 0.162 0.0932 1.31 0.955 1.81 ukb-melanoma-latest-gwas all 1014 Effects of heat, cold and air pressure Injuries & Poisonings Both 1.03 0.801 1.33 0.809 66 660 FALSE 0.0920514783877277 0.0306 0.127 0.281 0.353 0.426 1.32 0.657 2.72 0.17 0.355 0.632 1.19 0.583 2.44 -0.126 0.379 0.739 0.882 0.406 1.89 ukb-melanoma-latest-gwas all 1015 Effects of other external causes Injuries & Poisonings Both 1 0.969 1.03 0.977 4237 42370 FALSE 0.0101054362812269 0.000471 0.0162 0.0273 0.0454 0.548 1.03 0.94 1.12 -0.0071 0.0458 0.877 0.993 0.908 1.09 -0.0228 0.0461 0.622 0.978 0.893 1.07 ukb-melanoma-latest-gwas all 1019 Other ill-defined and unknown causes of morbidity and mortality Injuries & Poisonings Both 1 0.988 1.02 0.635 16056 160552 FALSE 0.197226274708024 0.00394 0.00831 0.0343 0.0235 0.144 1.03 0.988 1.08 0.0258 0.0235 0.274 1.03 0.98 1.07 0.0204 0.0236 0.389 1.02 0.974 1.07