prs_id slug legacy_id legacy_model prswebprefix trait_code trait_name trait_type description cohort cohort_label method gwas_source reference_label reference_url snp_count p_value pseudo_r2 brier_score mse aauc aauc_ci effect_metric top_effect_1 top_effect_1_ci top_or_1 top_or_1_ci top_effect_2 top_effect_2_ci top_or_2 top_or_2_ci top_effect_5 top_effect_5_ci top_or_5 top_or_5_ci top_effect_10 top_effect_10_ci top_or_10 top_or_10_ci top_effect_25 top_effect_25_ci top_or_25 top_or_25_ci q1_vs_q2_effect q1_vs_q2_effect_ci q1_vs_q2_p_value q1_vs_q3_effect q1_vs_q3_effect_ci q1_vs_q3_p_value q1_vs_q4_effect q1_vs_q4_effect_ci q1_vs_q4_p_value nominally_significant reversed_effect_warning underpowered_warning upload_to_portal sex cases controls genome_build tuning_parameter weights_external_url weights_url phewas_download_url exclusion_download_url last_updated mgi-melanoma-fixed-threshold-5e-04 mgi-melanoma-fixed-threshold-5e-04 172.11-UKB-5E-4-MGI UKB-5E-4 172.11-UKB-5E-4-MGI 172.11 Melanoma Binary Recovered from the first PRSweb skin cancer portal snapshot dated 2019-06-14. Historical top-percentile summaries were not preserved in the legacy bundle, but quartile enrichment and full PheWAS tables are preserved. This model was reconstructed from UK Biobank-derived summary-statistic depth comparisons in the 2019 manuscript supplement. MGI Michigan Genomics Initiative Fixed threshold (5e-04) UK Biobank summary statistics Fritsche et al. 2019 PRSweb manuscript https://pubmed.ncbi.nlm.nih.gov/31194742/ 1193 0.00011 0.094 0.54 0.52-0.55 OR 1.08 0.931-1.25 1.19 1.03-1.37 1.34 1.17-1.55 True False False True Both 1772 15654 GRCh37/hg19 P<=5e-04 /larsf/prsweb-data/skincancerprsweb/releases/skincancerprsweb_20190614/weights/172.11_UKB-5E-4_weights37.tsv /larsf/prsweb-data/skincancerprsweb/releases/skincancerprsweb_20190614/phewas/172.11-UKB-5E-4-MGI/all.tsv /larsf/prsweb-data/skincancerprsweb/releases/skincancerprsweb_20190614/phewas/172.11-UKB-5E-4-MGI/exclusion.tsv 2019-06-14 mgi-melanoma-fixed-threshold-5e-05 mgi-melanoma-fixed-threshold-5e-05 172.11-UKB-5E-5-MGI UKB-5E-5 172.11-UKB-5E-5-MGI 172.11 Melanoma Binary Recovered from the first PRSweb skin cancer portal snapshot dated 2019-06-14. Historical top-percentile summaries were not preserved in the legacy bundle, but quartile enrichment and full PheWAS tables are preserved. This model was reconstructed from UK Biobank-derived summary-statistic depth comparisons in the 2019 manuscript supplement. MGI Michigan Genomics Initiative Fixed threshold (5e-05) UK Biobank summary statistics Fritsche et al. 2019 PRSweb manuscript https://pubmed.ncbi.nlm.nih.gov/31194742/ 156 5.8e-20 0.094 0.56 0.54-0.58 OR 1.26 1.08-1.46 1.4 1.21-1.63 1.78 1.54-2.05 True False False True Both 1772 15654 GRCh37/hg19 P<=5e-05 /larsf/prsweb-data/skincancerprsweb/releases/skincancerprsweb_20190614/weights/172.11_UKB-5E-5_weights37.tsv /larsf/prsweb-data/skincancerprsweb/releases/skincancerprsweb_20190614/phewas/172.11-UKB-5E-5-MGI/all.tsv /larsf/prsweb-data/skincancerprsweb/releases/skincancerprsweb_20190614/phewas/172.11-UKB-5E-5-MGI/exclusion.tsv 2019-06-14 mgi-melanoma-fixed-threshold-5e-06 mgi-melanoma-fixed-threshold-5e-06 172.11-UKB-5E-6-MGI UKB-5E-6 172.11-UKB-5E-6-MGI 172.11 Melanoma Binary Recovered from the first PRSweb skin cancer portal snapshot dated 2019-06-14. Historical top-percentile summaries were not preserved in the legacy bundle, but quartile enrichment and full PheWAS tables are preserved. This model was reconstructed from UK Biobank-derived summary-statistic depth comparisons in the 2019 manuscript supplement. MGI Michigan Genomics Initiative Fixed threshold (5e-06) UK Biobank summary statistics Fritsche et al. 2019 PRSweb manuscript https://pubmed.ncbi.nlm.nih.gov/31194742/ 27 3.6e-36 0.093 0.58 0.56-0.6 OR 1.31 1.12-1.53 1.4 1.2-1.64 2.08 1.8-2.4 True False False True Both 1772 15654 GRCh37/hg19 P<=5e-06 /larsf/prsweb-data/skincancerprsweb/releases/skincancerprsweb_20190614/weights/172.11_UKB-5E-6_weights37.tsv /larsf/prsweb-data/skincancerprsweb/releases/skincancerprsweb_20190614/phewas/172.11-UKB-5E-6-MGI/all.tsv /larsf/prsweb-data/skincancerprsweb/releases/skincancerprsweb_20190614/phewas/172.11-UKB-5E-6-MGI/exclusion.tsv 2019-06-14 mgi-melanoma-fixed-threshold-5e-07 mgi-melanoma-fixed-threshold-5e-07 172.11-UKB-5E-7-MGI UKB-5E-7 172.11-UKB-5E-7-MGI 172.11 Melanoma Binary Recovered from the first PRSweb skin cancer portal snapshot dated 2019-06-14. Historical top-percentile summaries were not preserved in the legacy bundle, but quartile enrichment and full PheWAS tables are preserved. This model was reconstructed from UK Biobank-derived summary-statistic depth comparisons in the 2019 manuscript supplement. MGI Michigan Genomics Initiative Fixed threshold (5e-07) UK Biobank summary statistics Fritsche et al. 2019 PRSweb manuscript https://pubmed.ncbi.nlm.nih.gov/31194742/ 13 6.5e-47 0.093 0.59 0.58-0.61 OR 1.31 1.11-1.53 1.52 1.3-1.78 2.39 2.07-2.77 True False False True Both 1772 15654 GRCh37/hg19 P<=5e-07 /larsf/prsweb-data/skincancerprsweb/releases/skincancerprsweb_20190614/weights/172.11_UKB-5E-7_weights37.tsv /larsf/prsweb-data/skincancerprsweb/releases/skincancerprsweb_20190614/phewas/172.11-UKB-5E-7-MGI/all.tsv /larsf/prsweb-data/skincancerprsweb/releases/skincancerprsweb_20190614/phewas/172.11-UKB-5E-7-MGI/exclusion.tsv 2019-06-14 mgi-melanoma-fixed-threshold-5e-08 mgi-melanoma-fixed-threshold-5e-08 172.11-UKB-5E-8-MGI UKB-5E-8 172.11-UKB-5E-8-MGI 172.11 Melanoma Binary Recovered from the first PRSweb skin cancer portal snapshot dated 2019-06-14. Historical top-percentile summaries were not preserved in the legacy bundle, but quartile enrichment and full PheWAS tables are preserved. This model was reconstructed from UK Biobank-derived summary-statistic depth comparisons in the 2019 manuscript supplement. MGI Michigan Genomics Initiative Fixed threshold (5e-08) UK Biobank summary statistics Fritsche et al. 2019 PRSweb manuscript https://pubmed.ncbi.nlm.nih.gov/31194742/ 9 1.7e-46 0.093 0.59 0.58-0.61 OR 1.42 1.21-1.67 1.66 1.42-1.94 2.5 2.16-2.9 True False False True Both 1772 15654 GRCh37/hg19 P<=5e-08 /larsf/prsweb-data/skincancerprsweb/releases/skincancerprsweb_20190614/weights/172.11_UKB-5E-8_weights37.tsv /larsf/prsweb-data/skincancerprsweb/releases/skincancerprsweb_20190614/phewas/172.11-UKB-5E-8-MGI/all.tsv /larsf/prsweb-data/skincancerprsweb/releases/skincancerprsweb_20190614/phewas/172.11-UKB-5E-8-MGI/exclusion.tsv 2019-06-14 mgi-melanoma-fixed-threshold-5e-09 mgi-melanoma-fixed-threshold-5e-09 172.11-UKB-5E-9-MGI UKB-5E-9 172.11-UKB-5E-9-MGI 172.11 Melanoma Binary Recovered from the first PRSweb skin cancer portal snapshot dated 2019-06-14. Historical top-percentile summaries were not preserved in the legacy bundle, but quartile enrichment and full PheWAS tables are preserved. This model was reconstructed from UK Biobank-derived summary-statistic depth comparisons in the 2019 manuscript supplement. MGI Michigan Genomics Initiative Fixed threshold (5e-09) UK Biobank summary statistics Fritsche et al. 2019 PRSweb manuscript https://pubmed.ncbi.nlm.nih.gov/31194742/ 6 3.1e-34 0.093 0.58 0.56-0.59 OR 1.26 1.07-1.48 1.61 1.38-1.88 2.22 1.92-2.57 True False False True Both 1772 15654 GRCh37/hg19 P<=5e-09 /larsf/prsweb-data/skincancerprsweb/releases/skincancerprsweb_20190614/weights/172.11_UKB-5E-9_weights37.tsv /larsf/prsweb-data/skincancerprsweb/releases/skincancerprsweb_20190614/phewas/172.11-UKB-5E-9-MGI/all.tsv /larsf/prsweb-data/skincancerprsweb/releases/skincancerprsweb_20190614/phewas/172.11-UKB-5E-9-MGI/exclusion.tsv 2019-06-14 mgi-melanoma-gwas-catalog mgi-melanoma-gwas-catalog 172.11-GWAS-Catalog-MGI GWAS-Catalog 172.11-GWAS-Catalog-MGI 172.11 Melanoma Binary Recovered from the first PRSweb skin cancer portal snapshot dated 2019-06-14. Historical top-percentile summaries were not preserved in the legacy bundle, but quartile enrichment and full PheWAS tables are preserved. MGI Michigan Genomics Initiative GWAS Catalog GWAS Catalog GWAS Catalog loci https://www.ebi.ac.uk/gwas/ 29 1.3e-56 0.093 0.61 0.59-0.62 OR 1.38 1.17-1.64 1.95 1.67-2.29 2.76 2.37-3.22 True False False True Both 1772 15654 GRCh37/hg19 Published genome-wide significant loci /larsf/prsweb-data/skincancerprsweb/releases/skincancerprsweb_20190614/weights/172.11_GWAS-Catalog_weights37.tsv /larsf/prsweb-data/skincancerprsweb/releases/skincancerprsweb_20190614/phewas/172.11-GWAS-Catalog-MGI/all.tsv /larsf/prsweb-data/skincancerprsweb/releases/skincancerprsweb_20190614/phewas/172.11-GWAS-Catalog-MGI/exclusion.tsv 2019-06-14 mgi-melanoma-ldpred-0-001 mgi-melanoma-ldpred-0-001 172.11-UKB-LDpred-0.001-MGI UKB-LDpred-0.001 172.11-UKB-LDpred-0.001-MGI 172.11 Melanoma Binary Recovered from the first PRSweb skin cancer portal snapshot dated 2019-06-14. Historical top-percentile summaries were not preserved in the legacy bundle, but quartile enrichment and full PheWAS tables are preserved. This model was reconstructed from UK Biobank-derived summary-statistic depth comparisons in the 2019 manuscript supplement. MGI Michigan Genomics Initiative LDpred (0.001%) UK Biobank summary statistics Fritsche et al. 2019 PRSweb manuscript https://pubmed.ncbi.nlm.nih.gov/31194742/ 3.2e-50 0.024 0.093 0.6 0.58-0.62 OR 1.29 1.1-1.52 1.67 1.43-1.96 2.41 2.08-2.79 True False False False Both 1772 15654 GRCh37/hg19 LDpred causal fraction 0.001% /larsf/prsweb-data/skincancerprsweb/releases/skincancerprsweb_20190614/phewas/172.11-UKB-LDpred-0.001-MGI/all.tsv /larsf/prsweb-data/skincancerprsweb/releases/skincancerprsweb_20190614/phewas/172.11-UKB-LDpred-0.001-MGI/exclusion.tsv 2019-06-14 mgi-melanoma-latest-gwas mgi-melanoma-latest-gwas 172.11-Latest-GWAS-MGI Latest-GWAS 172.11-Latest-GWAS-MGI 172.11 Melanoma Binary Recovered from the first PRSweb skin cancer portal snapshot dated 2019-06-14. Historical top-percentile summaries were not preserved in the legacy bundle, but quartile enrichment and full PheWAS tables are preserved. MGI Michigan Genomics Initiative Latest GWAS Latest published GWAS Ransohoff et al. 2017 https://pubmed.ncbi.nlm.nih.gov/28212542/ 20 1.2e-55 0.093 0.6 0.59-0.62 OR 1.3 1.1-1.46 2.08 1.78-2.45 2.71 2.32-3.16 True False False True Both 1772 15654 GRCh37/hg19 Latest published genome-wide significant loci /larsf/prsweb-data/skincancerprsweb/releases/skincancerprsweb_20190614/weights/172.11_Latest-GWAS_weights37.tsv /larsf/prsweb-data/skincancerprsweb/releases/skincancerprsweb_20190614/phewas/172.11-Latest-GWAS-MGI/all.tsv /larsf/prsweb-data/skincancerprsweb/releases/skincancerprsweb_20190614/phewas/172.11-Latest-GWAS-MGI/exclusion.tsv 2019-06-14