Melanomas of skin (MGI) · Skin Cancer PRSweb

Scores Trait 172.11 Michigan Genomics Initiative

Melanomas of skin

Exact trait key: 172.11

Show note

Recovered from the first PRSweb skin cancer portal snapshot dated 2019-06-14. Historical top-percentile summaries were not preserved in the legacy bundle, but quartile enrichment and full PheWAS tables are preserved. This model was reconstructed from UK Biobank-derived summary-statistic depth comparisons in the 2019 manuscript supplement.

Binary MGI Fixed threshold (5e-05) UK Biobank summary statistics nominally significant

Model details

PRS IDmgi-melanoma-fixed-threshold-5e-05

Legacy ID172.11-UKB-5E-5-MGI

Legacy modelUKB-5E-5

Evaluation cohortMichigan Genomics Initiative

Trait typeBinary

SexBoth

Cases1772

Controls15654

Genome buildGRCh37/hg19

Tuning parameterP<=5e-05

Reference Fritsche et al. 2019 PRSweb manuscript
PubMed 31194742

Last updated2019-06-14

Performance summary

# SNPs156

P value5.8e-20

Pseudo-R²

Brier score0.094

AAUC0.56

AAUC CI0.54-0.58

Percentile effect metricOR

Top percentile	OR	95% CI
1%
2%
5%
10%
25%

How to use this score page

Start with P value and the main performance metrics above to judge whether this model is useful in this cohort.
Use the top-percentile rows to see how strongly the score separates the upper PRS tail.
Use the linked PheWAS follow-up after the primary-trait evaluation, not as a substitute for it.

Flag guide: nominally significant passed the preserved release's nominal threshold; reversed effect means the observed direction ran opposite to the expected effect direction in the preserved evaluation.

Files and next steps

Start with the interactive PheWAS page to inspect notable associations for this score. Use the PRS PheWAS file for the full phenome scan, the exclusion PheWAS file for secondary associations after removing primary or related trait cases, and the weight link when you need the score construction itself. See the Method page for metric definitions and cohort context.