Skin cancer (MGI) · Skin Cancer PRSweb

Scores Evaluation trait 172 Michigan Genomics Initiative

Skin cancer

Exact trait key: 172

Show note

Recovered from the first PRSweb skin cancer portal snapshot dated 2019-06-14. Historical top-percentile summaries were not preserved in the legacy bundle, but quartile enrichment and full PheWAS tables are preserved. This model was reconstructed from UK Biobank-derived summary-statistic depth comparisons in the 2019 manuscript supplement.

Binary MGI LDpred (1%) UK Biobank summary statistics nominally significant

Model details

PRS IDmgi-skin-cancer-ldpred-1

Legacy ID172-UKB-LDpred-1-MGI

Legacy modelUKB-LDpred-1

# SNPs

Discovery GWAS trait/source UK Biobank summary statistics

Genome buildGRCh37/hg19

Tuning parameterLDpred causal fraction 1%

Reference Publication Fritsche et al. 2019 PRSweb manuscript
PubMed 31194742

Last updated2019-06-14

Evaluation details

Evaluation cohortMichigan Genomics Initiative

Evaluation trait Skin Cancer
172

Trait typeBinary

SexBoth

Cases4503

Controls22747

PRS performance

P value3e-55

Pseudo-R²0.017

Brier score0.140

AAUC0.570

AAUC CI0.560-0.580

Percentile effect metricOR

Top percentile	OR	95% CI
1%
2%
5%
10%
25%

How to use this score page

Start with P value and the main performance metrics above to judge whether this model is useful in this cohort.
Use the top-percentile rows to see how strongly the score separates the upper PRS tail.
Use the linked PheWAS follow-up after the primary-trait evaluation, not as a substitute for it.

Flag guide: nominally significant passed the preserved release's nominal threshold; reversed effect means the observed direction ran opposite to the expected effect direction in the preserved evaluation.

Files and next steps

Start with the interactive PheWAS page to inspect notable associations for this score. Use the PRS PheWAS file for the full phenome scan, the exclusion PheWAS file for secondary associations after removing primary or related trait cases, and the weight link when you need the score construction itself. See the Method page for metric definitions and cohort context.