Squamous cell carcinoma (MGI) · Skin Cancer PRSweb

Scores Trait 172.22 Michigan Genomics Initiative

Squamous cell carcinoma

Exact trait key: 172.22

Show note

Recovered from the first PRSweb skin cancer portal snapshot dated 2019-06-14. Historical top-percentile summaries were not preserved in the legacy bundle, but quartile enrichment and full PheWAS tables are preserved.

Binary MGI Latest GWAS Latest published GWAS nominally significant

Score-level evaluation metrics are shown for Michigan Genomics Initiative. This PRS also has preserved PheWAS follow-up in MGI, UKB.

Model details

PRS IDmgi-squamous-cell-carcinoma-latest-gwas

Legacy ID172.22-Latest-GWAS-MGI

Legacy modelLatest-GWAS

Evaluation cohortMichigan Genomics Initiative

PheWAS follow-upMGI, UKB

Trait typeBinary

SexBoth

Cases836

Controls7436

Genome buildGRCh37/hg19

Tuning parameterLatest published genome-wide significant loci

Reference Chahal et al. 2016b
PubMed 27424798

Last updated2019-06-14

Performance summary

# SNPs10

P value2.1e-21

Pseudo-R²

Brier score0.091

AAUC0.59

AAUC CI0.56-0.61

Percentile effect metricOR

Top percentile	OR	95% CI
1%
2%
5%
10%
25%

How to use this score page

Start with P value and the main performance metrics above to judge whether this model is useful in this cohort.
Use the top-percentile rows to see how strongly the score separates the upper PRS tail.
Use the linked PheWAS follow-up after the primary-trait evaluation, not as a substitute for it.

Flag guide: nominally significant passed the preserved release's nominal threshold; reversed effect means the observed direction ran opposite to the expected effect direction in the preserved evaluation.

Files and next steps

Start with the interactive PheWAS pages to inspect notable associations for this score. Use the PRS PheWAS file for the full phenome scan, the exclusion PheWAS file for secondary associations after removing primary or related trait cases, and the weight link when you need the score construction itself. See the Method page for metric definitions and cohort context.