AAAgen Consortium GWAS Meta-Analysis Results
Result Files
AAA GWAS meta-analysis summary statistics from AAAgen(2023) with README
Polygenic risk score weights from AAAgen meta-analyis
Polygenic risk score weights from AAAgen meta-analyis without UK biobank
Reference
Roychowdhury et al. (2023) GWAS meta-analysis deciphers genetic architecture of abdominal aortic aneurysm and highlights PCSK9 as a therapeutic target. Nature Genetics.
Description
GWAS meta-analysis of 17 summary statistics from 14 discovery cohorts by AAAgen consortium. The analysis consisted of 39,221 individuals with AAA (37,214 of European ancestry and 2,007 of African ancestry).
Columns in AAAgen Meta-Analysis Summary Statistics
| Column Label | Description |
| chr | Chromosome |
| pos | Position (hg19) |
| ref | Non-effect allele |
| alt | Effect allele |
| N | Number of cases+controls |
| AF | Allele frequency of effect allele |
| Direction | Effect direction in individual cohorts |
| Effectsize | Effectsize |
| Effectsize_SD | Effectsize_SD |
| pvalue | P-value |
Please e-mail
Cristen Willer with comments or
suggestions.
| 
