University of Michigan Center for Statistical 


International AMD Genomics Consortium Study of Age Related Macular Degeneration

GWAS Results Table

The table below summarizes the results of the genome-wide analysis described in Fritsche et al. (2016) Nature Genetics. The table includes nine columns: the rs# for each SNP evaluated (if available, otherwise "chromosome:position"), chromosome and position in genome-build 37, the two alleles of the SNP in genome-build 37, the number of cases and controls evaluated for the SNP, the p-value for the SNP, the overall direction of effect (a positive statistic indicates allele 1 was associated with increased risk of macular degeneration). The files includes both genotyped and imputed SNPs and are provided in a compressed text file to conserve space.

To browse results in a user friendly fashion, try LocusZoom, and request the option to plot the published GWAS results ("Choose Pre-loaded Data Type" → Age-related Macular Degeneration → International_AMD_Consortium_2015_hg19)

Advanced AMD vs. Control Analysis              GZIP Archive (about 150 MB)

Columns in Result File:

Column Label Description
Marker This is the marker name.
Chrom This is the chromosome
Pos This is the position in genome-build 37
Allele1 This the allele used as the effect allele.
Allele2 This is the "other" allele.
Ncases The number of cases analysed for this marker.
Ncontrols The number of controls analysed for this marker.
GC.Pvalue P-value, after genomic control correction.
Overall Overall direction of effect. Positive values indicate allele1 was associated with increased disease risk.

CITATION: If you use these GWAS results in any published work, please cite the following manuscript:
Fritsche et al. (2015). A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants. Nature Genetics. Advance online publication. doi:10.1038/ng.3448

Please e-mail Goncalo Abecasis or Lars Fritsche with comments or suggestions.


University of Michigan | School of Public Health | Abecasis Lab