University of Michigan Center for Statistical 


AMD Gene Consortium Study of Age Related Macular Degeneration

Meta-Analysis Tables

The three tables below summarize the results of the meta-analysis described in Fritsche et al, Nature Genetics (2013). Each table includes seven columns: the rs# for each SNP evaluated, the two alleles of the SNP in genome-build 37, the number of cases and controls evaluated for the SNP, the combined p-value for the SNP, the overall direction of effect (a positive statistic indicates allele 1 was associated with increased risk of macular degeneration). The files included both genotyped and imputed SNPs and are provided in a compressed text file to conserve space.

To browse results in a user friendly fashion, try LocusZoom, and request the option to plot published GWAS results.

Advanced AMD vs. Control Analysis              GZIP Archive
Geographic Atrophy vs. Control Analysis        GZIP Archive
Neovascular Disease vs. Control Analysis       GZIP Archive

Columns in Result Files

Column Label Description
Marker This is the marker name.
Allele1 This the allele used as the effect allele.
Allele2 This is the "other" allele.
Ncases The number of cases analysed for this marker.
Ncontrols The number of controls analysed for this marker.
GC.Pvalue Meta-analysis p-value, after genomic control correction.
Overall Overall direction of effect. Positive values indicate allele1 was associated with increased disease risk.

NOTE:These files were updated on April 24, 2013 to fix a formatting issue; that resulted in wrong direction of effect for several SNPs.

CITATION:If you use these GWAS results in any published work, please cite the following manuscript:
Fritsche, L.G. et al. Seven new loci associated with age-related macular degeneration. Nat Genet. 2013 Apr;45(4):433-9, 439e1-2. doi: 10.1038/ng.2578. PubMed PMID: 23455636.

Please e-mail Goncalo Abecasis or Lars Fritsche with comments or suggestions.


University of Michigan | School of Public Health | Abecasis Lab