AMD Gene Consortium Study of Age Related Macular Degeneration
The three tables below summarize the results of the meta-analysis described
in Fritsche et al, Nature Genetics (2013). Each table includes seven
columns: the rs# for each SNP evaluated, the two alleles of the SNP in genome-build
37, the number of cases and controls evaluated for the SNP,
the combined p-value for the SNP, the overall direction of effect
(a positive statistic indicates allele 1 was associated with increased
risk of macular degeneration). The files included both genotyped and imputed SNPs
and are provided in a compressed text file to conserve space.
To browse results in a user friendly fashion, try LocusZoom, and
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Advanced AMD vs. Control Analysis GZIP Archive
Geographic Atrophy vs. Control Analysis GZIP Archive
Neovascular Disease vs. Control Analysis GZIP Archive
Columns in Result Files
| Column Label || Description |
| Marker || This is the marker name.|
| Allele1 || This the allele used as the effect allele.|
| Allele2 || This is the "other" allele.|
| Ncases || The number of cases analysed for this marker.|
| Ncontrols || The number of controls analysed for this marker.|
| GC.Pvalue || Meta-analysis p-value, after genomic control correction.|
| Overall || Overall direction of effect. Positive values indicate allele1 was associated with increased disease risk.|
NOTE:These files were updated on April 24, 2013 to fix a formatting
issue; that resulted in wrong direction of effect for several SNPs.
CITATION:If you use these GWAS results in any published work, please cite the following manuscript:
Fritsche, L.G. et al. Seven new loci associated with age-related macular degeneration. Nat Genet. 2013 Apr;45(4):433-9, 439e1-2. doi: 10.1038/ng.2578. PubMed PMID: 23455636.
Please e-mail Goncalo Abecasis or
Lars Fritsche with comments or