The three tables below summarize the results of the meta-analysis described in Teslovich et al, Nature (2010). Each table includes eight columns: the rs# for each SNP evaluated, the two alleles of the SNP in genome-build 36, the number of individuals evaluated for this SNP, the combined z-statistic for the SNP, the combined p-value for each SNP, the overall direction of effect (a positive statistic indicates allele 1 was associated with increased trait values), and a summary of the observed direction effect in each study contributing to the meta-analysis. The files included both genotyped and imputed SNPs and are provided in a compressed text file to conserve space. Further annotation of file contents is available at the bottom of this webpage
Update: Tables that also include effect size estimates, in standard deviation units, for each variant are now also available for download. Please note that these files are quite a bit larger (about 40%).
RESULT FILES Total Cholesterol Meta-Analysis Results TC2010.zip TC_with_Effect.zip HDL-C Meta-Analysis Results HDL2010.zip HDL_with_Effect.zip LDL-C Meta-Analysis Results LDL2010.zip LDL_with_Effect.zip Triglycerides Meta-Analysis Results TG2010.zip TG_with_Effect.zipResults for our previous meta-analyses are also available online, see Kathiresan et al, 2009 results and Willer et al, 2008 results.
|Marker||This is the marker name.|
|Allele1||This the allele used as the effect allele.|
|Allele2||This is the "other" allele.|
|Weight||The sum of the individual study weights (typically, N) for this marker.|
|GC.Zscore||The combined z-statistic for this marker, after genomic control correction.|
|GC.Pvalue||Meta-analysis p-value, after genomic control correction.|
|Overall||Overall direction of effect. Positive values indicate allele1 raises trait values.|
|Direction||Summary of effect direction for each study, with one '+', '-' or '=' per study. Missing values labeled as '?'.|
|Effect||Effect size estimates in standard deviation units.|
|StdErr||Standard error for effect size estiamtes.|
|Study 4||Framingham Heart Study|
|Study 5||FUSION (Meta-analysis of T2D cases and controls)|
|Study 14||ENGAGE (Meta-analysis of FINRISK, NFBC66, RS-I, RS-II, GENMETS, ERF, MICROS, NSPHS, ORCADES, Vis, and six twin studies)|
|Study 21||MEDSTAR (Meta-analysis of myocardial infarction cases and controls)|
|Study 22||PENNCATH (Meta-analysis of myocardial infarction cases and controls)|
|Study 24||DGI (Meta-analysis of T2D cases and controls)|
|Study 25||Family Heart Study|
Please e-mail Goncalo Abecasis or Tanya Teslovich with comments or suggestions.