Genome-wide association analysis identifies three psoriasis susceptibility loci.

Stuart PE, Nair RP, Ellinghaus E, Ding J, Tejasvi T, Gudjonsson JE, Li Y, Weidinger S, Eberlein B, Gieger C, Wichmann HE, Kunz M, Ike R, Krueger GG, Bowcock AM, Mrowietz U, Lim HW, Voorhees JJ, Abecasis GR, Weichenthal M, Franke A, Rahman P, Gladman DD and Elder JT

Nat Genet (2010) 42:1000-4

We carried out a meta-analysis of two recent psoriasis genome-wide association studies with a combined discovery sample of 1,831 affected individuals (cases) and 2,546 controls. One hundred and two loci selected based on P value rankings were followed up in a three-stage replication study including 4,064 cases and 4,685 controls from Michigan, Toronto, Newfoundland and Germany. In the combined meta-analysis, we identified three new susceptibility loci, including one at NOS2 (rs4795067, combined P = 4 x 10(1)(1)), one at FBXL19 (rs10782001, combined P = 9 x 10(1)) and one near PSMA6-NFKBIA (rs12586317, combined P = 2 x 10). All three loci were also associated with psoriatic arthritis (rs4795067, combined P = 1 x 10; rs10782001, combined P = 4 x 10; and rs12586317, combined P = 6 x 1) and purely cutaneous psoriasis (rs4795067, combined P = 1 x 10; rs10782001, combined P = 2 x 10; and rs12586317, combined P = 1 x 10). We also replicated a recently identified association signal near RNF114 (rs495337, combined P = 2 x 10).