Departments of Anesthesiology and Biostatistics | University of Michigan

Polygenic risk score research portal

Cancer PRSweb

Compare evaluated PRS models, inspect score-level performance, and follow results into PheWAS analyses.

Phecodes 153

Colorectal cancer

153 Neoplasms Both 150-159.99, 208-208.99

Start with these models

These rows keep nominally significant, warning-free models first and sort the retained set by the smallest preserved p-value. Use them as a starting comparison set, not a definitive ranking.

Model Cohort Method P value Top 1% effect Flags Links
Colorectal cancer
Cancer code, self-reported: large bowel cancer/colorectal cancer (UKB GWAS (PHESANT)) 		UKB Fixed threshold (5e-05) 4.5e-83 4
OR
nominal retained
detail
Colorectal cancer
Cancer code, self-reported: large bowel cancer/colorectal cancer (UKB GWAS (PHESANT)) 		UKB P&T 4.5e-83 4
OR
nominal retained
detail
PheWAS
Colorectal cancer
Cancer code, self-reported: large bowel cancer/colorectal cancer (UKB GWAS (PHESANT)) 		UKB Fixed threshold (5e-06) 1.7e-82 3.85
OR
nominal retained
detail
Colorectal cancer
Cancer code, self-reported: large bowel cancer/colorectal cancer (UKB GWAS (PHESANT)) 		UKB Fixed threshold (5e-07) 6.6e-81 3.85
OR
nominal retained
detail
Colorectal cancer
Cancer code, self-reported: large bowel cancer/colorectal cancer (UKB GWAS (PHESANT)) 		UKB GWAS Hits 3.6e-76 3.85
OR
nominal retained
detail
PheWAS
Colorectal cancer
Cancer code, self-reported: large bowel cancer/colorectal cancer (UKB GWAS (PHESANT)) 		UKB Fixed threshold (5e-09) 4.8e-69 3.39
OR
nominal retained
detail
Colorectal cancer
Cancer code, self-reported: large bowel cancer/colorectal cancer (UKB GWAS (PHESANT)) 		UKB Fixed threshold (5e-05) 1.3e-29 2.1
OR
nominal retained
detail
Colorectal cancer
Cancer code, self-reported: large bowel cancer/colorectal cancer (UKB GWAS (PHESANT)) 		UKB P&T 1.3e-29 2.1
OR
nominal retained
detail
PheWAS

All related PRS models (33)

Multiple rows can map to the same phecode because cohort and PRS construction method differ. The full list below remains an unranked jump list; use the filtered Scores table for side-by-side comparison.

Compare related models in Scores table
Open full related-model jump list

ICD mappings

ICD code Type Description Phenome
C18 ICD10CM Malignant neoplasm of colon MGI
C18.0 ICD10CM Malignant neoplasm of cecum MGI
C18.1 ICD10CM Malignant neoplasm of appendix MGI
C18.2 ICD10CM Malignant neoplasm of ascending colon MGI
C18.3 ICD10CM Malignant neoplasm of hepatic flexure MGI
C18.4 ICD10CM Malignant neoplasm of transverse colon MGI
C18.5 ICD10CM Malignant neoplasm of splenic flexure MGI
C18.6 ICD10CM Malignant neoplasm of descending colon MGI
C18.7 ICD10CM Malignant neoplasm of sigmoid colon MGI
C18.8 ICD10CM Malignant neoplasm of overlapping sites of colon MGI
C18.9 ICD10CM Malignant neoplasm of colon, unspecified MGI
C19 ICD10CM Malignant neoplasm of rectosigmoid junction MGI
C20 ICD10CM Malignant neoplasm of rectum MGI
C21.0 ICD10CM Malignant neoplasm of anus, unspecified MGI
C21.1 ICD10CM Malignant neoplasm of anal canal MGI
C21.2 ICD10CM Malignant neoplasm of cloacogenic zone MGI
C21.8 ICD10CM Malignant neoplasm of overlapping sites of rectum, anus and anal canal MGI
C26.0 ICD10CM Malignant neoplasm of intestinal tract, part unspecified MGI
C7A.020 ICD10CM Malignant carcinoid tumor of the appendix MGI
C7A.021 ICD10CM Malignant carcinoid tumor of the cecum MGI
C7A.022 ICD10CM Malignant carcinoid tumor of the ascending colon MGI
C7A.023 ICD10CM Malignant carcinoid tumor of the transverse colon MGI
C7A.024 ICD10CM Malignant carcinoid tumor of the descending colon MGI
C7A.025 ICD10CM Malignant carcinoid tumor of the sigmoid colon MGI
C7A.026 ICD10CM Malignant carcinoid tumor of the rectum MGI
C7A.029 ICD10CM Malignant carcinoid tumor of the large intestine, unspecified portion MGI
D01.0 ICD10CM Carcinoma in situ of colon MGI
D01.1 ICD10CM Carcinoma in situ of rectosigmoid junction MGI
D01.2 ICD10CM Carcinoma in situ of rectum MGI
D01.3 ICD10CM Carcinoma in situ of anus and anal canal MGI
R85.610 ICD10CM Atypical squamous cells of undetermined significance on cytologic smear of anus (ASC-US) MGI
R85.611 ICD10CM Atypical squamous cells cannot exclude high grade squamous intraepithelial lesion on cytologic smear of anus (ASC-H) MGI
R85.612 ICD10CM Low grade squamous intraepithelial lesion on cytologic smear of anus (LGSIL) MGI
R85.613 ICD10CM High grade squamous intraepithelial lesion on cytologic smear of anus (HGSIL) MGI
R85.614 ICD10CM Cytologic evidence of malignancy on smear of anus MGI
R85.619 ICD10CM Unspecified abnormal cytological findings in specimens from anus MGI
153.0 ICD9CM Malignant neoplasm of hepatic flexure MGI
153.1 ICD9CM Malignant neoplasm of transverse colon MGI
153.2 ICD9CM Malignant neoplasm of descending colon MGI
153.3 ICD9CM Malignant neoplasm of sigmoid colon MGI
153.4 ICD9CM Malignant neoplasm of cecum MGI
153.5 ICD9CM Malignant neoplasm of appendix vermiformis MGI
153.6 ICD9CM Malignant neoplasm of ascending colon MGI
153.7 ICD9CM Malignant neoplasm of splenic flexure MGI
153.8 ICD9CM Malignant neoplasm of other specified sites of large intestine MGI
153.9 ICD9CM Malignant neoplasm of colon, unspecified site MGI
154.0 ICD9CM Malignant neoplasm of rectosigmoid junction MGI
154.1 ICD9CM Malignant neoplasm of rectum MGI
154.2 ICD9CM Malignant neoplasm of anal canal MGI
154.3 ICD9CM Malignant neoplasm of anus, unspecified site MGI
154.8 ICD9CM Malignant neoplasm of other sites of rectum, rectosigmoid junction, and anus MGI
159.0 ICD9CM Malignant neoplasm of intestinal tract, part unspecified MGI
209.10 ICD9CM Malignant carcinoid tumor of the large intestine, unspecified portion MGI
209.11 ICD9CM Malignant carcinoid tumor of the appendix MGI
209.12 ICD9CM Malignant carcinoid tumor of the cecum MGI
209.13 ICD9CM Malignant carcinoid tumor of the ascending colon MGI
209.14 ICD9CM Malignant carcinoid tumor of the transverse colon MGI
209.15 ICD9CM Malignant carcinoid tumor of the descending colon MGI
209.16 ICD9CM Malignant carcinoid tumor of the sigmoid colon MGI
209.17 ICD9CM Malignant carcinoid tumor of the rectum MGI
230.3 ICD9CM Carcinoma in situ of colon MGI
230.4 ICD9CM Carcinoma in situ of rectum MGI
230.5 ICD9CM Carcinoma in situ of anal canal MGI
230.6 ICD9CM Carcinoma in situ of anus, unspecified MGI
796.70 ICD9CM Abnormal glandular Papanicolaou smear of anus MGI
796.71 ICD9CM Papanicolaou smear of anus with atypical squamous cells of undetermined significance (ASC-US) MGI
796.72 ICD9CM Papanicolaou smear of anus with atypical squamous cells cannot exclude high grade squamous intraepithelial lesion (ASC-H) MGI
796.73 ICD9CM Papanicolaou smear of anus with low grade squamous intraepithelial lesion (LGSIL) MGI
796.74 ICD9CM Papanicolaou smear of anus with high grade squamous intraepithelial lesion (HGSIL) MGI
796.76 ICD9CM Papanicolaou smear of anus with cytologic evidence of malignancy MGI
V10.05 ICD9CM Personal history of malignant neoplasm of large intestine MGI
V10.06 ICD9CM Personal history of malignant neoplasm of rectum, rectosigmoid junction, and anus MGI
C18.0 ICD10 C18.0 Caecum UKB
C18.1 ICD10 C18.1 Appendix UKB
C18.2 ICD10 C18.2 Ascending colon UKB
C18.3 ICD10 C18.3 Hepatic flexure UKB
C18.4 ICD10 C18.4 Transverse colon UKB
C18.5 ICD10 C18.5 Splenic flexure UKB
C18.6 ICD10 C18.6 Descending colon UKB
C18.7 ICD10 C18.7 Sigmoid colon UKB
C18.8 ICD10 C18.8 Overlapping lesion of colon UKB
C18.9 ICD10 C18.9 Colon, unspecified UKB
C19 ICD10 C19 Malignant neoplasm of rectosigmoid junction UKB
C20 ICD10 C20 Malignant neoplasm of rectum UKB
C21.0 ICD10 C21.0 Anus, unspecified UKB
C21.1 ICD10 C21.1 Anal canal UKB
C21.8 ICD10 C21.8 Overlapping lesion of rectum, anus and anal canal UKB
C26.0 ICD10 C26.0 Intestinal tract, part unspecified UKB
D01.0 ICD10 D01.0 Colon UKB
D01.1 ICD10 D01.1 Rectosigmoid junction UKB
D01.2 ICD10 D01.2 Rectum UKB
D01.3 ICD10 D01.3 Anus and anal canal UKB
154.8 ICD9 1548 Malignant neoplasm of rectum, rectosigmoid junction and anus, other UKB
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